locus-tag	class	description
EPD59_RS00010	COG4771	TonB-dependent receptor
EPD59_RS00015	COG1528	Iron-storage protein
EPD59_RS00030	COG1730	sister chromatid segregation
EPD59_RS00055	COG1742	UPF0060 membrane protein
EPD59_RS00070	COG2217	Heavy metal translocating P-type atpase
EPD59_RS00080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EPD59_RS00265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPD59_RS00265	COG2755	lipolytic protein G-D-S-L family
EPD59_RS00320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EPD59_RS00325	COG0829	nickel cation binding
EPD59_RS00355	COG4771	TonB-dependent receptor
EPD59_RS00375	COG4804	nuclease activity
EPD59_RS00380	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EPD59_RS00405	COG0714	Associated with various cellular activities
EPD59_RS00425	COG0494	nUDIX hydrolase
EPD59_RS00430	COG1349	DNA-binding transcription factor activity
EPD59_RS00520	COG2314	TM2 domain
EPD59_RS00595	COG1968	undecaprenyl-diphosphatase activity
EPD59_RS00620	COG5002	protein histidine kinase activity
EPD59_RS00625	COG0745	RESPONSE REGULATOR receiver
EPD59_RS00670	COG5002	protein histidine kinase activity
EPD59_RS00675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPD59_RS00700	COG3547	Transposase (IS116 IS110 IS902 family)
EPD59_RS00730	COG2132	Multicopper oxidase
EPD59_RS00770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPD59_RS00795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPD59_RS00920	COG0423	glycine-tRNA ligase activity
EPD59_RS00935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPD59_RS00940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPD59_RS00945	COG0444	Belongs to the ABC transporter superfamily
EPD59_RS00950	COG4172	Belongs to the ABC transporter superfamily
EPD59_RS00955	COG0557	exoribonuclease II activity
EPD59_RS00980	COG0584	glycerophosphoryl diester phosphodiesterase
EPD59_RS00990	COG1607	acyl-coa hydrolase
EPD59_RS01000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPD59_RS01005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPD59_RS01020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPD59_RS01035	COG1187	pseudouridine synthase activity
EPD59_RS01040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EPD59_RS01075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPD59_RS01075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EPD59_RS01100	COG1137	ATPase activity
EPD59_RS01125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPD59_RS01125	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EPD59_RS01130	COG0251	oxidation-reduction process
EPD59_RS01135	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD59_RS01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPD59_RS01150	COG0297	glycogen (starch) synthase activity
EPD59_RS01155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPD59_RS01165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EPD59_RS01175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPD59_RS01175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPD59_RS01185	COG1960	acyl-CoA dehydrogenase activity
EPD59_RS01195	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EPD59_RS01210	COG0484	heat shock protein binding
EPD59_RS01220	COG1215	transferase activity, transferring glycosyl groups
EPD59_RS01230	COG0247	lactate metabolic process
EPD59_RS01230	COG2181	nitrate reductase activity
EPD59_RS01235	COG0247	lactate metabolic process
EPD59_RS01235	COG2181	nitrate reductase activity
EPD59_RS01265	COG0183	Belongs to the thiolase family
EPD59_RS01280	COG1132	(ABC) transporter
EPD59_RS01320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPD59_RS01330	COG0473	3-isopropylmalate dehydrogenase activity
EPD59_RS01340	COG1862	Preprotein translocase
EPD59_RS01385	COG0668	transmembrane transport
EPD59_RS01405	COG5002	protein histidine kinase activity
EPD59_RS01420	COG0531	amino acid
EPD59_RS01430	COG1215	transferase activity, transferring glycosyl groups
EPD59_RS01440	COG1442	glycosyl transferase family 8
EPD59_RS01440	COG1216	Glycosyl transferase, family 2
EPD59_RS01465	COG0697	spore germination
EPD59_RS01475	COG1266	CAAX protease self-immunity
EPD59_RS01480	COG0575	Belongs to the CDS family
EPD59_RS01485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPD59_RS01490	COG0688	phosphatidylethanolamine metabolic process
EPD59_RS01495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPD59_RS01495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPD59_RS01520	COG1956	GAF domain-containing protein
EPD59_RS01525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPD59_RS01525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPD59_RS01530	COG2890	protein-(glutamine-N5) methyltransferase activity
EPD59_RS01545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPD59_RS01555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS01560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EPD59_RS01590	COG2201	protein-glutamate methylesterase activity
EPD59_RS01595	COG4864	UPF0365 protein
EPD59_RS01610	COG0442	prolyl-tRNA aminoacylation
EPD59_RS01630	COG1506	peptidase
EPD59_RS01630	COG0823	Involved in the tonB-independent uptake of proteins
EPD59_RS01665	COG0463	Glycosyl transferase, family 2
EPD59_RS01675	COG0662	Cupin 2, conserved barrel domain protein
EPD59_RS01680	COG3844	kynureninase activity
EPD59_RS01695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPD59_RS01700	COG3279	Response regulator of the LytR AlgR family
EPD59_RS01705	COG2205	protein histidine kinase activity
EPD59_RS01705	COG0784	Response regulator, receiver
EPD59_RS01715	COG3015	lipoprotein NlpE involved in copper resistance
EPD59_RS01720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EPD59_RS01750	COG1595	DNA-templated transcription, initiation
EPD59_RS01795	COG1024	Enoyl-CoA hydratase
EPD59_RS01800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPD59_RS01805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPD59_RS01815	COG1611	Belongs to the LOG family
EPD59_RS01830	COG1120	ATPase activity
EPD59_RS01845	COG0488	(ABC) transporter
EPD59_RS01965	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EPD59_RS01970	COG3386	PFAM SMP-30 Gluconolaconase
EPD59_RS01975	COG2135	peptidase activity
EPD59_RS01990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPD59_RS02025	COG0714	Associated with various cellular activities
EPD59_RS02065	COG1401	restriction endodeoxyribonuclease activity
EPD59_RS02100	COG2814	Major facilitator Superfamily
EPD59_RS02115	COG1538	Outer membrane efflux protein
EPD59_RS02130	COG1523	belongs to the glycosyl hydrolase 13 family
EPD59_RS02140	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPD59_RS02155	COG0242	peptide deformylase activity
EPD59_RS02160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPD59_RS02180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPD59_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS02275	COG0113	porphobilinogen synthase activity
EPD59_RS02285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPD59_RS02305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPD59_RS02310	COG0006	proline dipeptidase activity
EPD59_RS02315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPD59_RS02325	COG0552	protein localization to endoplasmic reticulum
EPD59_RS02330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPD59_RS02335	COG2755	lipolytic protein G-D-S-L family
EPD59_RS02335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPD59_RS02340	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EPD59_RS02345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPD59_RS02360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPD59_RS02360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EPD59_RS02390	COG1295	ribonuclease BN
EPD59_RS02405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS02435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPD59_RS02450	COG0601	transmembrane transport
EPD59_RS02455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPD59_RS02480	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD59_RS02485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPD59_RS02515	COG0022	dehydrogenase e1 component
EPD59_RS02530	COG3118	belongs to the thioredoxin family
EPD59_RS02545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPD59_RS02635	COG0567	Dehydrogenase, E1 component
EPD59_RS02640	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPD59_RS02650	COG0697	spore germination
EPD59_RS02695	COG2133	pyrroloquinoline quinone binding
EPD59_RS02700	COG2133	pyrroloquinoline quinone binding
EPD59_RS02705	COG2207	Transcriptional regulator
EPD59_RS02710	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EPD59_RS02715	COG1278	Cold shock
EPD59_RS02720	COG1187	pseudouridine synthase activity
EPD59_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS02750	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EPD59_RS02760	COG1136	(ABC) transporter
EPD59_RS02770	COG1136	(ABC) transporter
EPD59_RS02770	COG0577	efflux transmembrane transporter activity
EPD59_RS02775	COG1136	(ABC) transporter
EPD59_RS02775	COG0577	efflux transmembrane transporter activity
EPD59_RS02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPD59_RS02795	COG0693	protein deglycase activity
EPD59_RS02815	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPD59_RS02840	COG2072	flavoprotein involved in K transport
EPD59_RS02860	COG0167	dihydroorotate dehydrogenase activity
EPD59_RS02865	COG0284	orotidine-5'-phosphate decarboxylase activity
EPD59_RS02870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPD59_RS02875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPD59_RS02885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPD59_RS02900	COG0151	Belongs to the GarS family
EPD59_RS02905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPD59_RS02920	COG0702	epimerase
EPD59_RS02955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EPD59_RS02965	COG0723	plastoquinol--plastocyanin reductase activity
EPD59_RS02980	COG2197	response regulator
EPD59_RS03015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPD59_RS03025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPD59_RS03030	COG2010	Cytochrome c
EPD59_RS03045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPD59_RS03060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPD59_RS03065	COG0436	Aminotransferase
EPD59_RS03105	COG1629	transport
EPD59_RS03115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EPD59_RS03125	COG0346	lactoylglutathione lyase activity
EPD59_RS03130	COG2764	glyoxalase bleomycin resistance protein dioxygenase
EPD59_RS03135	COG2169	Transcriptional regulator
EPD59_RS03160	COG0402	S-adenosylhomocysteine deaminase activity
EPD59_RS03170	COG2885	chlorophyll binding
EPD59_RS03180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPD59_RS03230	COG0861	Integral membrane protein TerC family
EPD59_RS03265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPD59_RS03270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPD59_RS03295	COG4251	negative regulation of phosphorylation
EPD59_RS03300	COG0714	Associated with various cellular activities
EPD59_RS03330	COG1561	YicC-like family, N-terminal region
EPD59_RS03340	COG2234	aminopeptidase activity
EPD59_RS03350	COG0509	glycine decarboxylation via glycine cleavage system
EPD59_RS03370	COG0632	four-way junction helicase activity
EPD59_RS03375	COG0280	phosphate acetyltransferase
EPD59_RS03375	COG0281	malic enzyme
EPD59_RS03380	COG1388	LysM domain
EPD59_RS03380	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPD59_RS03385	COG0154	amidase activity
EPD59_RS03390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPD59_RS03395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPD59_RS03400	COG5000	phosphorelay sensor kinase activity
EPD59_RS03400	COG3279	Response regulator of the LytR AlgR family
EPD59_RS03405	COG1619	proteins homologs of microcin C7 resistance protein MccF
EPD59_RS03410	COG0237	dephospho-CoA kinase activity
EPD59_RS03410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPD59_RS03440	COG0779	Required for maturation of 30S ribosomal subunits
EPD59_RS03445	COG0195	Participates in both transcription termination and antitermination
EPD59_RS03450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPD59_RS03450	COG5180	pathogenesis
EPD59_RS03470	COG1024	Enoyl-CoA hydratase
EPD59_RS03480	COG0756	dUTP diphosphatase activity
EPD59_RS03510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPD59_RS03515	COG2873	o-acetylhomoserine
EPD59_RS03535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPD59_RS03545	COG2267	carboxylic ester hydrolase activity
EPD59_RS03550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPD59_RS03565	COG4771	TonB-dependent receptor
EPD59_RS03570	COG1914	H( )-stimulated, divalent metal cation uptake system
EPD59_RS03620	COG4974	Belongs to the 'phage' integrase family
EPD59_RS03625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPD59_RS03630	COG1960	acyl-CoA dehydrogenase activity
EPD59_RS03640	COG3206	protein involved in exopolysaccharide biosynthesis
EPD59_RS03640	COG0489	protein tyrosine kinase activity
EPD59_RS03645	COG4464	protein tyrosine phosphatase activity
EPD59_RS03650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS03660	COG1809	phosphosulfolactate synthase activity
EPD59_RS03675	COG0586	Pfam SNARE associated Golgi protein
EPD59_RS03680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPD59_RS03685	COG0655	NAD(P)H dehydrogenase (quinone) activity
EPD59_RS03710	COG0556	nucleotide-excision repair
EPD59_RS03720	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPD59_RS03720	COG1404	Belongs to the peptidase S8 family
EPD59_RS03730	COG2989	Protein conserved in bacteria
EPD59_RS03795	COG2094	Belongs to the DNA glycosylase MPG family
EPD59_RS03815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EPD59_RS03820	COG0463	Glycosyl transferase, family 2
EPD59_RS03850	COG0194	GDP metabolic process
EPD59_RS03860	COG0233	cytoplasmic translational termination
EPD59_RS03865	COG0528	UMP kinase activity
EPD59_RS03870	COG4770	biotin carboxylase activity
EPD59_RS03915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EPD59_RS03920	COG0081	regulation of translation
EPD59_RS03925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPD59_RS03930	COG0222	ribosome binding
EPD59_RS03935	COG0085	RNA polymerase activity
EPD59_RS03950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EPD59_RS03955	COG0049	tRNA binding
EPD59_RS03960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPD59_RS03965	COG0051	transcription antitermination factor activity, RNA binding
EPD59_RS03975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPD59_RS03980	COG0088	Forms part of the polypeptide exit tunnel
EPD59_RS03985	COG0089	rRNA binding
EPD59_RS03990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPD59_RS03995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPD59_RS04000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPD59_RS04005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPD59_RS04010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EPD59_RS04015	COG0255	Belongs to the universal ribosomal protein uL29 family
EPD59_RS04020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPD59_RS04025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPD59_RS04030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPD59_RS04040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPD59_RS04045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPD59_RS04050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPD59_RS04060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EPD59_RS04065	COG1841	ribosomal large subunit assembly
EPD59_RS04070	COG0200	Binds to the 23S rRNA
EPD59_RS04075	COG0201	protein transport
EPD59_RS04085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPD59_RS04090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPD59_RS04095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPD59_RS04100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPD59_RS04110	COG0202	RNA polymerase activity
EPD59_RS04115	COG0203	ribosomal protein L17
EPD59_RS04120	COG0148	phosphopyruvate hydratase activity
EPD59_RS04150	COG0248	Ppx GppA phosphatase
EPD59_RS04155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPD59_RS04155	COG0116	Belongs to the methyltransferase superfamily
EPD59_RS04165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPD59_RS04185	COG0653	protein targeting
EPD59_RS04200	COG1473	amidohydrolase
EPD59_RS04215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPD59_RS04225	COG0024	Methionine aminopeptidase
EPD59_RS04245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPD59_RS04275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPD59_RS04280	COG3781	membrane
EPD59_RS04285	COG0583	DNA-binding transcription factor activity
EPD59_RS04290	COG2855	membrane
EPD59_RS04325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPD59_RS04330	COG0052	Belongs to the universal ribosomal protein uS2 family
EPD59_RS04335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPD59_RS04340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPD59_RS04350	COG5002	protein histidine kinase activity
EPD59_RS04355	COG0745	RESPONSE REGULATOR receiver
EPD59_RS04365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPD59_RS04390	COG0714	Associated with various cellular activities
EPD59_RS04400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPD59_RS04405	COG2172	sigma factor antagonist activity
EPD59_RS04425	COG0516	GMP reductase activity
EPD59_RS04425	COG0517	IMP dehydrogenase activity
EPD59_RS04430	COG1643	Atp-dependent helicase
EPD59_RS04435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPD59_RS04490	COG2255	four-way junction helicase activity
EPD59_RS04500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPD59_RS04535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPD59_RS04560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPD59_RS04570	COG0572	uridine kinase
EPD59_RS04575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPD59_RS04580	COG0254	rRNA binding
EPD59_RS04590	COG0470	DNA polymerase III
EPD59_RS04595	COG0181	hydroxymethylbilane synthase activity
EPD59_RS04600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPD59_RS04615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPD59_RS04620	COG0601	transmembrane transport
EPD59_RS04655	COG0514	ATP-dependent DNA helicase (RecQ)
EPD59_RS04660	COG0517	IMP dehydrogenase activity
EPD59_RS04660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPD59_RS04670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPD59_RS04695	COG0799	negative regulation of ribosome biogenesis
EPD59_RS04700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPD59_RS04715	COG1556	Lactate utilization protein
EPD59_RS04720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD59_RS04765	COG1278	Cold shock
EPD59_RS04770	COG1278	Cold shock
EPD59_RS04795	COG0671	phosphoesterase, PA-phosphatase related
EPD59_RS04825	COG2373	Large extracellular alpha-helical protein
EPD59_RS04830	COG2373	Large extracellular alpha-helical protein
EPD59_RS04845	COG0633	Ferredoxin
EPD59_RS04850	COG0492	ferredoxin-NADP+ reductase activity
EPD59_RS04865	COG0626	cystathionine gamma-synthase activity
EPD59_RS04885	COG1830	Aldolase
EPD59_RS04890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPD59_RS04905	COG2885	chlorophyll binding
EPD59_RS04910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPD59_RS04915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPD59_RS04925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPD59_RS04940	COG1522	sequence-specific DNA binding
EPD59_RS04950	COG3118	belongs to the thioredoxin family
EPD59_RS04965	COG1388	LysM domain
EPD59_RS04965	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPD59_RS04990	COG0612	Peptidase, M16
EPD59_RS05000	COG0006	proline dipeptidase activity
EPD59_RS05005	COG2885	chlorophyll binding
EPD59_RS05035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPD59_RS05035	COG1796	DNA polymerase
EPD59_RS05040	COG0859	PFAM glycosyl transferase family 9
EPD59_RS05060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPD59_RS05125	COG1090	epimerase
EPD59_RS05130	COG0302	gtp cyclohydrolase
EPD59_RS05145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPD59_RS05160	COG0335	large ribosomal subunit rRNA binding
EPD59_RS05165	COG0336	Belongs to the RNA methyltransferase TrmD family
EPD59_RS05170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPD59_RS05175	COG0228	four-way junction DNA binding
EPD59_RS05185	COG0564	pseudouridine synthase activity
EPD59_RS05190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPD59_RS05200	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPD59_RS05245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPD59_RS05285	COG0346	lactoylglutathione lyase activity
EPD59_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS05315	COG2259	Doxx family
EPD59_RS05325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD59_RS05325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD59_RS05330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD59_RS05350	COG0737	Belongs to the 5'-nucleotidase family
EPD59_RS05355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPD59_RS05365	COG1764	response to oxidative stress
EPD59_RS05390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPD59_RS05395	COG0750	zinc metalloprotease
EPD59_RS05420	COG5520	Belongs to the glycosyl hydrolase 30 family
EPD59_RS05430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPD59_RS05440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EPD59_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS05460	COG4771	TonB-dependent receptor
EPD59_RS05465	COG0702	epimerase
EPD59_RS05470	COG4771	TonB-dependent receptor
EPD59_RS05475	COG0702	epimerase
EPD59_RS05480	COG4771	TonB-dependent receptor
EPD59_RS05495	COG1629	transport
EPD59_RS05510	COG4771	TonB-dependent receptor
EPD59_RS05515	COG4771	TonB-dependent receptor
EPD59_RS05530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPD59_RS05540	COG1136	(ABC) transporter
EPD59_RS05550	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPD59_RS05570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPD59_RS05575	COG0784	Response regulator, receiver
EPD59_RS05580	COG4251	negative regulation of phosphorylation
EPD59_RS05590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EPD59_RS05595	COG2045	Belongs to the ComB family
EPD59_RS05600	COG1694	Mazg nucleotide pyrophosphohydrolase
EPD59_RS05605	COG1490	D-aminoacyl-tRNA deacylase activity
EPD59_RS05620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPD59_RS05625	COG2226	methyltransferase
EPD59_RS05630	COG3800	Transcriptional regulator
EPD59_RS05630	COG1396	sequence-specific DNA binding
EPD59_RS05635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPD59_RS05640	COG2224	Isocitrate lyase
EPD59_RS05645	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EPD59_RS05650	COG0165	Argininosuccinate lyase
EPD59_RS05670	COG0137	argininosuccinate synthase activity
EPD59_RS05675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPD59_RS05685	COG0505	Belongs to the CarA family
EPD59_RS05700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPD59_RS05705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPD59_RS05710	COG1629	transport
EPD59_RS05715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPD59_RS05740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EPD59_RS05745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPD59_RS05770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPD59_RS05805	COG0359	binds to the 23S rRNA
EPD59_RS05810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EPD59_RS05815	COG0360	Binds together with S18 to 16S ribosomal RNA
EPD59_RS05825	COG0437	4 iron, 4 sulfur cluster binding
EPD59_RS05850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPD59_RS05855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPD59_RS05865	COG0109	protoheme IX farnesyltransferase activity
EPD59_RS05875	COG1845	cytochrome c oxidase, subunit III
EPD59_RS05905	COG5000	phosphorelay sensor kinase activity
EPD59_RS05925	COG0714	Associated with various cellular activities
EPD59_RS05955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPD59_RS05955	COG3153	acetyltransferase
EPD59_RS05975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPD59_RS05980	COG0196	riboflavin kinase activity
EPD59_RS05985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPD59_RS05990	COG1968	undecaprenyl-diphosphatase activity
EPD59_RS06000	COG2177	Part of the ABC transporter FtsEX involved in
EPD59_RS06010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPD59_RS06020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPD59_RS06025	COG0791	NLP P60 protein
EPD59_RS06040	COG2267	carboxylic ester hydrolase activity
EPD59_RS06055	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPD59_RS06055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPD59_RS06070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPD59_RS06085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPD59_RS06095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPD59_RS06105	COG1475	DNA binding
EPD59_RS06110	COG1192	Involved in chromosome partitioning
EPD59_RS06125	COG4166	transmembrane transport
EPD59_RS06135	COG0504	CTP synthase activity
EPD59_RS06140	COG2027	D-alanyl-D-alanine carboxypeptidase
EPD59_RS06145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPD59_RS06150	COG2323	membrane
EPD59_RS06195	COG0667	Aldo Keto reductase
EPD59_RS06200	COG1501	Belongs to the glycosyl hydrolase 31 family
EPD59_RS06255	COG0705	Rhomboid family
EPD59_RS06290	COG2205	protein histidine kinase activity
EPD59_RS06290	COG0784	Response regulator, receiver
EPD59_RS06290	COG2198	Histidine kinase
EPD59_RS06290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPD59_RS06295	COG1649	PFAM Uncharacterised BCR, COG1649
EPD59_RS06300	COG1629	transport
EPD59_RS06330	COG0318	PFAM AMP-dependent synthetase and ligase
EPD59_RS06335	COG1472	Belongs to the glycosyl hydrolase 3 family
EPD59_RS06360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPD59_RS06380	COG2514	catechol 2,3-dioxygenase activity
EPD59_RS06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD59_RS06410	COG3011	Protein conserved in bacteria
EPD59_RS06415	COG1846	Transcriptional regulator
EPD59_RS06420	COG0604	alcohol dehydrogenase
EPD59_RS06435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS06440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPD59_RS06445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPD59_RS06455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD59_RS06470	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPD59_RS06480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPD59_RS06540	COG0463	Glycosyl transferase, family 2
EPD59_RS06560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPD59_RS06570	COG0463	Glycosyl transferase, family 2
EPD59_RS06575	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EPD59_RS06580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPD59_RS06595	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EPD59_RS06600	COG0018	arginyl-trna synthetase
EPD59_RS06610	COG0386	Belongs to the glutathione peroxidase family
EPD59_RS06625	COG1472	Belongs to the glycosyl hydrolase 3 family
EPD59_RS06630	COG4771	TonB-dependent receptor
EPD59_RS06635	COG0702	epimerase
EPD59_RS06665	COG0513	Belongs to the DEAD box helicase family
EPD59_RS06670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EPD59_RS06680	COG0180	Tryptophanyl-tRNA synthetase
EPD59_RS06690	COG1234	tRNA 3'-trailer cleavage
EPD59_RS06705	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD59_RS06715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPD59_RS06730	COG1288	antiporter activity
EPD59_RS06750	COG0475	glutathione-regulated potassium exporter activity
EPD59_RS06750	COG0589	response to stress
EPD59_RS06770	COG2153	protein acetylation
EPD59_RS06775	COG1228	amidohydrolase
EPD59_RS06780	COG0673	inositol 2-dehydrogenase activity
EPD59_RS06790	COG4771	TonB-dependent receptor
EPD59_RS06810	COG3275	phosphorelay sensor kinase activity
EPD59_RS06815	COG3279	Response regulator of the LytR AlgR family
EPD59_RS06830	COG3275	phosphorelay sensor kinase activity
EPD59_RS06845	COG5001	Diguanylate cyclase
EPD59_RS06900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPD59_RS06905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EPD59_RS06910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EPD59_RS06925	COG0406	alpha-ribazole phosphatase activity
EPD59_RS06940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPD59_RS06960	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS07020	COG0154	amidase activity
EPD59_RS07030	COG0488	(ABC) transporter
EPD59_RS07045	COG3876	Protein conserved in bacteria
EPD59_RS07070	COG2824	Alkylphosphonate utilization operon protein PhnA
EPD59_RS07090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EPD59_RS07130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPD59_RS07140	COG1051	belongs to the nudix hydrolase family
EPD59_RS07150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPD59_RS07165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPD59_RS07170	COG2304	oxidoreductase activity
EPD59_RS07190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPD59_RS07215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPD59_RS07225	COG4948	Mandelate Racemase Muconate Lactonizing
EPD59_RS07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPD59_RS07250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPD59_RS07260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPD59_RS07265	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EPD59_RS07280	COG0488	(ABC) transporter
EPD59_RS07290	COG4999	Histidine kinase
EPD59_RS07290	COG3850	Histidine kinase
EPD59_RS07290	COG3437	response regulator, receiver
EPD59_RS07290	COG2205	protein histidine kinase activity
EPD59_RS07310	COG0754	glutathionylspermidine amidase activity
EPD59_RS07340	COG0346	lactoylglutathione lyase activity
EPD59_RS07350	COG0617	tRNA 3'-terminal CCA addition
EPD59_RS07390	COG3876	Protein conserved in bacteria
EPD59_RS07395	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPD59_RS07405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPD59_RS07405	COG1017	nitric oxide dioxygenase activity
EPD59_RS07420	COG2151	metal-sulfur cluster biosynthetic enzyme
EPD59_RS07435	COG3396	Phenylacetate-CoA oxygenase
EPD59_RS07440	COG1309	transcriptional regulator
EPD59_RS07490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPD59_RS07625	COG2610	gluconate transmembrane transporter activity
EPD59_RS07630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EPD59_RS07640	COG4181	ATPase activity
EPD59_RS07660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EPD59_RS07665	COG1984	allophanate hydrolase subunit 2
EPD59_RS07675	COG1914	H( )-stimulated, divalent metal cation uptake system
EPD59_RS07685	COG3275	phosphorelay sensor kinase activity
EPD59_RS07690	COG1131	(ABC) transporter
EPD59_RS07695	COG0308	aminopeptidase N
EPD59_RS07705	COG0494	nUDIX hydrolase
EPD59_RS07715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPD59_RS07740	COG4771	TonB-dependent receptor
EPD59_RS07790	COG2217	Heavy metal translocating P-type atpase
EPD59_RS07820	COG2378	regulation of single-species biofilm formation
EPD59_RS07835	COG4221	oxidoreductase activity
EPD59_RS07850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPD59_RS07855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPD59_RS07905	COG1609	Transcriptional regulator
EPD59_RS07915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPD59_RS07920	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPD59_RS07930	COG1446	asparaginase
EPD59_RS07960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPD59_RS07980	COG2211	Major facilitator Superfamily
EPD59_RS07995	COG0673	inositol 2-dehydrogenase activity
EPD59_RS08015	COG2814	Major facilitator Superfamily
EPD59_RS08025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPD59_RS08030	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPD59_RS08060	COG0667	Aldo Keto reductase
EPD59_RS08075	COG0339	signal peptide processing
EPD59_RS08110	COG0596	Alpha beta hydrolase
EPD59_RS08155	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPD59_RS08175	COG1690	Belongs to the RtcB family
EPD59_RS08180	COG1690	Belongs to the RtcB family
EPD59_RS08205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPD59_RS08215	COG0783	Belongs to the Dps family
EPD59_RS08230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EPD59_RS08230	COG0321	lipoyl(octanoyl) transferase activity
EPD59_RS08240	COG0205	6-phosphofructokinase activity
EPD59_RS08270	COG0784	Response regulator, receiver
EPD59_RS08270	COG2205	protein histidine kinase activity
EPD59_RS08275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPD59_RS08290	COG1595	DNA-templated transcription, initiation
EPD59_RS08305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPD59_RS08315	COG3959	Transketolase, thiamine diphosphate binding domain
EPD59_RS08320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPD59_RS08325	COG3040	lipid binding
EPD59_RS08330	COG0739	heme binding
EPD59_RS08335	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPD59_RS08355	COG0305	Participates in initiation and elongation during chromosome replication
EPD59_RS08380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPD59_RS08400	COG0300	oxidoreductase activity
EPD59_RS08430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EPD59_RS08435	COG0384	phenazine biosynthesis protein PhzF
EPD59_RS08450	COG1538	Outer membrane efflux protein
EPD59_RS08485	COG2814	Major facilitator Superfamily
EPD59_RS08505	COG2201	protein-glutamate methylesterase activity
EPD59_RS08545	COG3387	PFAM Glycoside hydrolase 15-related
EPD59_RS08555	COG0745	RESPONSE REGULATOR receiver
EPD59_RS08555	COG2205	protein histidine kinase activity
EPD59_RS08555	COG3292	Two component regulator propeller
EPD59_RS08565	COG4771	TonB-dependent receptor
EPD59_RS08570	COG4206	TonB-dependent receptor
EPD59_RS08570	COG1629	transport
EPD59_RS08580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPD59_RS08580	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPD59_RS08585	COG1621	beta-fructofuranosidase activity
EPD59_RS08590	COG2755	lipolytic protein G-D-S-L family
EPD59_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS08615	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EPD59_RS08625	COG0702	epimerase
EPD59_RS08650	COG2721	sulfolactate sulfo-lyase activity
EPD59_RS08655	COG1904	glucuronate isomerase
EPD59_RS08670	COG2271	Major facilitator Superfamily
EPD59_RS08685	COG0673	inositol 2-dehydrogenase activity
EPD59_RS08695	COG1917	Cupin 2, conserved barrel domain protein
EPD59_RS08695	COG2207	Transcriptional regulator
EPD59_RS08720	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EPD59_RS08730	COG1136	(ABC) transporter
EPD59_RS08730	COG0577	efflux transmembrane transporter activity
EPD59_RS08735	COG0577	efflux transmembrane transporter activity
EPD59_RS08755	COG5000	phosphorelay sensor kinase activity
EPD59_RS08760	COG1073	alpha beta
EPD59_RS08790	COG0028	Belongs to the TPP enzyme family
EPD59_RS08795	COG0440	acetolactate synthase activity
EPD59_RS08800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPD59_RS08805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPD59_RS08810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPD59_RS08815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPD59_RS08820	COG0066	3-isopropylmalate dehydratase activity
EPD59_RS08850	COG0538	isocitrate dehydrogenase activity
EPD59_RS08860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPD59_RS08940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPD59_RS09005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPD59_RS09025	COG4717	serine-type aminopeptidase activity
EPD59_RS09030	COG3339	Conserved Protein
EPD59_RS09055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EPD59_RS09100	COG0308	aminopeptidase N
EPD59_RS09105	COG2989	Protein conserved in bacteria
EPD59_RS09130	COG0494	nUDIX hydrolase
EPD59_RS09145	COG5002	protein histidine kinase activity
EPD59_RS09155	COG2723	6-phospho-beta-galactosidase activity
EPD59_RS09160	COG1858	cytochrome C peroxidase
EPD59_RS09175	COG1082	Xylose isomerase domain protein TIM barrel
EPD59_RS09185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPD59_RS09190	COG0793	Belongs to the peptidase S41A family
EPD59_RS09210	COG3541	Predicted nucleotidyltransferase
EPD59_RS09230	COG4206	TonB-dependent receptor
EPD59_RS09230	COG1629	transport
EPD59_RS09275	COG1012	belongs to the aldehyde dehydrogenase family
EPD59_RS09280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPD59_RS09295	COG0493	'glutamate synthase
EPD59_RS09300	COG0167	dihydroorotate dehydrogenase activity
EPD59_RS09310	COG0596	Alpha beta hydrolase
EPD59_RS09315	COG4251	negative regulation of phosphorylation
EPD59_RS09350	COG1741	Belongs to the pirin family
EPD59_RS09355	COG0778	Nitroreductase
EPD59_RS09355	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EPD59_RS09360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPD59_RS09370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPD59_RS09390	COG2989	Protein conserved in bacteria
EPD59_RS09405	COG3781	membrane
EPD59_RS09435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD59_RS09440	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPD59_RS09475	COG3104	oligopeptide transport
EPD59_RS09485	COG0459	protein refolding
EPD59_RS09490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPD59_RS09515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPD59_RS09520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPD59_RS09535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPD59_RS09540	COG5002	protein histidine kinase activity
EPD59_RS09545	COG2205	protein histidine kinase activity
EPD59_RS09555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EPD59_RS09575	COG2204	response regulator
EPD59_RS09585	COG1663	tetraacyldisaccharide 4'-kinase activity
EPD59_RS09625	COG1136	(ABC) transporter
EPD59_RS09625	COG0577	efflux transmembrane transporter activity
EPD59_RS09635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPD59_RS09835	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EPD59_RS09870	COG0581	inorganic phosphate transmembrane transporter activity
EPD59_RS09880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPD59_RS09920	COG3321	synthase
EPD59_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS09920	COG0604	alcohol dehydrogenase
EPD59_RS09930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPD59_RS09970	COG2315	Protein conserved in bacteria
EPD59_RS09985	COG0495	leucyl-tRNA aminoacylation
EPD59_RS10020	COG1629	transport
EPD59_RS10025	COG4206	TonB-dependent receptor
EPD59_RS10025	COG1629	transport
EPD59_RS10030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPD59_RS10050	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EPD59_RS10100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPD59_RS10125	COG0758	DNA mediated transformation
EPD59_RS10125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPD59_RS10135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPD59_RS10145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPD59_RS10150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD59_RS10160	COG1607	acyl-coa hydrolase
EPD59_RS10165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPD59_RS10170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPD59_RS10175	COG1301	dicarboxylic acid transport
EPD59_RS10215	COG0387	Pfam Sodium calcium exchanger
EPD59_RS10235	COG0671	phosphoesterase, PA-phosphatase related
EPD59_RS10240	COG0408	coproporphyrinogen oxidase activity
EPD59_RS10245	COG0022	dehydrogenase e1 component
EPD59_RS10265	COG3265	gluconokinase activity
EPD59_RS10275	COG3279	Response regulator of the LytR AlgR family
EPD59_RS10310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPD59_RS10390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPD59_RS10390	COG0574	Belongs to the PEP-utilizing enzyme family
EPD59_RS10405	COG0673	inositol 2-dehydrogenase activity
EPD59_RS10465	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EPD59_RS10470	COG1902	pentaerythritol trinitrate reductase activity
EPD59_RS10475	COG0667	Aldo Keto reductase
EPD59_RS10495	COG1760	l-serine dehydratase
EPD59_RS10510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPD59_RS10515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPD59_RS10575	COG1131	(ABC) transporter
EPD59_RS10595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPD59_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS10625	COG2514	catechol 2,3-dioxygenase activity
EPD59_RS10640	COG0424	maF-like protein
EPD59_RS10665	COG1678	Uncharacterized ACR, COG1678
EPD59_RS10695	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EPD59_RS10700	COG4251	negative regulation of phosphorylation
EPD59_RS10705	COG4251	negative regulation of phosphorylation
EPD59_RS10710	COG5002	protein histidine kinase activity
EPD59_RS10715	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD59_RS10740	COG4771	TonB-dependent receptor
EPD59_RS10750	COG1193	negative regulation of DNA recombination
EPD59_RS10760	COG0738	Major facilitator superfamily
EPD59_RS10770	COG0116	Belongs to the methyltransferase superfamily
EPD59_RS10775	COG0366	Alpha amylase catalytic
EPD59_RS10785	COG0514	ATP-dependent DNA helicase (RecQ)
EPD59_RS10805	COG1741	Belongs to the pirin family
EPD59_RS10820	COG1051	belongs to the nudix hydrolase family
EPD59_RS10835	COG0513	Belongs to the DEAD box helicase family
EPD59_RS10840	COG2814	Major facilitator Superfamily
EPD59_RS10870	COG2010	Cytochrome c
EPD59_RS10875	COG1999	signal sequence binding
EPD59_RS10890	COG0667	Aldo Keto reductase
EPD59_RS10905	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
EPD59_RS10920	COG0038	chloride channel
EPD59_RS10925	COG0668	transmembrane transport
EPD59_RS10965	COG1309	transcriptional regulator
EPD59_RS10990	COG1609	Transcriptional regulator
EPD59_RS10990	COG2207	Transcriptional regulator
EPD59_RS10995	COG0667	Aldo Keto reductase
EPD59_RS11000	COG0657	acetylesterase activity
EPD59_RS11000	COG2755	lipolytic protein G-D-S-L family
EPD59_RS11025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPD59_RS11025	COG2010	Cytochrome c
EPD59_RS11030	COG2080	2 iron, 2 sulfur cluster binding
EPD59_RS11040	COG1289	transmembrane transporter activity
EPD59_RS11045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPD59_RS11055	COG0210	DNA helicase
EPD59_RS11060	COG2852	Protein conserved in bacteria
EPD59_RS11065	COG1074	ATP-dependent DNA helicase activity
EPD59_RS11095	COG0513	Belongs to the DEAD box helicase family
EPD59_RS11105	COG0596	Alpha beta hydrolase
EPD59_RS11110	COG2081	HI0933 family
EPD59_RS11115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS11145	COG1418	mRNA catabolic process
EPD59_RS11175	COG0584	glycerophosphoryl diester phosphodiesterase
EPD59_RS11185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPD59_RS11195	COG3852	Histidine kinase
EPD59_RS11215	COG0671	phosphoesterase, PA-phosphatase related
EPD59_RS11245	COG0107	imidazoleglycerol-phosphate synthase activity
EPD59_RS11255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPD59_RS11260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPD59_RS11265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPD59_RS11265	COG0131	Imidazoleglycerol-phosphate dehydratase
EPD59_RS11320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPD59_RS11350	COG0482	sulfurtransferase activity
EPD59_RS11355	COG0135	phosphoribosylanthranilate isomerase activity
EPD59_RS11370	COG0285	dihydrofolate synthase activity
EPD59_RS11380	COG0848	biopolymer transport protein
EPD59_RS11420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPD59_RS11440	COG0156	8-amino-7-oxononanoate synthase activity
EPD59_RS11445	COG0439	Biotin carboxylase
EPD59_RS11455	COG0739	heme binding
EPD59_RS11460	COG0492	ferredoxin-NADP+ reductase activity
EPD59_RS11465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPD59_RS11470	COG1185	polyribonucleotide nucleotidyltransferase activity
EPD59_RS11475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPD59_RS11510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPD59_RS11515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPD59_RS11520	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EPD59_RS11525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPD59_RS11545	COG1741	Belongs to the pirin family
EPD59_RS11570	COG0628	permease
EPD59_RS11580	COG1199	ATP-dependent helicase activity
EPD59_RS11580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPD59_RS11615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPD59_RS11630	COG2205	protein histidine kinase activity
EPD59_RS11640	COG4771	TonB-dependent receptor
EPD59_RS11650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPD59_RS11670	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD59_RS11695	COG3292	Two component regulator propeller
EPD59_RS11695	COG2205	protein histidine kinase activity
EPD59_RS11695	COG0745	RESPONSE REGULATOR receiver
EPD59_RS11700	COG3292	Two component regulator propeller
EPD59_RS11700	COG2205	protein histidine kinase activity
EPD59_RS11700	COG0745	RESPONSE REGULATOR receiver
EPD59_RS11720	COG0612	Peptidase, M16
EPD59_RS11750	COG3278	Belongs to the heme-copper respiratory oxidase family
EPD59_RS11765	COG2010	Cytochrome c
EPD59_RS11770	COG0348	domain, Protein
EPD59_RS11790	COG0408	coproporphyrinogen oxidase activity
EPD59_RS11800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPD59_RS11830	COG3275	phosphorelay sensor kinase activity
EPD59_RS11850	COG4783	chaperone-mediated protein folding
EPD59_RS11890	COG0488	(ABC) transporter
EPD59_RS11905	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD59_RS11920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EPD59_RS11925	COG2171	N-acyltransferase activity
EPD59_RS11935	COG4946	Tricorn protease homolog
EPD59_RS11935	COG0793	Belongs to the peptidase S41A family
EPD59_RS11945	COG3852	Histidine kinase
EPD59_RS11955	COG0584	glycerophosphoryl diester phosphodiesterase
EPD59_RS11970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPD59_RS12005	COG0602	queuosine metabolic process
EPD59_RS12010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPD59_RS12020	COG0481	GTPase activity
EPD59_RS12055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD59_RS12055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD59_RS12055	COG1703	isobutyryl-CoA mutase activity
EPD59_RS12080	COG0768	penicillin binding
EPD59_RS12105	COG2226	methyltransferase
EPD59_RS12110	COG0667	Aldo Keto reductase
EPD59_RS12150	COG3158	transport of potassium into the cell
EPD59_RS12205	COG1845	cytochrome c oxidase, subunit III
EPD59_RS12230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPD59_RS12235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPD59_RS12235	COG0301	tRNA thio-modification
EPD59_RS12260	COG0247	lactate metabolic process
EPD59_RS12290	COG1360	Flagellar Motor Protein
EPD59_RS12340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPD59_RS12380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPD59_RS12380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPD59_RS12415	COG4206	TonB-dependent receptor
EPD59_RS12415	COG1629	transport
EPD59_RS12420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPD59_RS12435	COG0358	DNA primase activity
EPD59_RS12445	COG0489	protein tyrosine kinase activity
EPD59_RS12450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EPD59_RS12460	COG3781	membrane
EPD59_RS12485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPD59_RS12495	COG0745	RESPONSE REGULATOR receiver
EPD59_RS12500	COG5002	protein histidine kinase activity
EPD59_RS12525	COG2234	aminopeptidase activity
EPD59_RS12535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPD59_RS12550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPD59_RS12570	COG0802	atpase or kinase
EPD59_RS12625	COG2204	response regulator
EPD59_RS12640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPD59_RS12640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPD59_RS12645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD59_RS12665	COG1058	Belongs to the CinA family
EPD59_RS12665	COG1546	Belongs to the CinA family
EPD59_RS12670	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPD59_RS12685	COG0525	valine-tRNA ligase activity
EPD59_RS12700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPD59_RS12720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPD59_RS12725	COG1054	Belongs to the UPF0176 family
EPD59_RS12755	COG1674	ftsk spoiiie
EPD59_RS12760	COG4974	Belongs to the 'phage' integrase family
EPD59_RS12765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPD59_RS12775	COG2095	MarC family integral membrane protein
EPD59_RS12780	COG0328	RNA-DNA hybrid ribonuclease activity
EPD59_RS12790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EPD59_RS12800	COG0295	cytidine deaminase activity
EPD59_RS12815	COG4585	Histidine kinase
EPD59_RS12820	COG4221	oxidoreductase activity
EPD59_RS12830	COG2226	methyltransferase
EPD59_RS12840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EPD59_RS12845	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPD59_RS12855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPD59_RS12860	COG0527	aspartate kinase activity
EPD59_RS12870	COG0735	belongs to the Fur family
EPD59_RS12875	COG0450	alkyl hydroperoxide reductase
EPD59_RS12880	COG1519	Transferase
EPD59_RS12885	COG1162	GTPase activity
EPD59_RS12890	COG4221	oxidoreductase activity
EPD59_RS12895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD59_RS12900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPD59_RS12935	COG2217	Heavy metal translocating P-type atpase
EPD59_RS12955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPD59_RS13025	COG0598	Magnesium transport protein CorA
EPD59_RS13045	COG0531	amino acid
EPD59_RS13065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPD59_RS13070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPD59_RS13085	COG0596	Alpha beta hydrolase
EPD59_RS13095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPD59_RS13155	COG1012	belongs to the aldehyde dehydrogenase family
EPD59_RS13185	COG2223	nitrite transmembrane transporter activity
EPD59_RS13210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPD59_RS13230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPD59_RS13245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EPD59_RS13250	COG0416	fatty acid biosynthetic process
EPD59_RS13255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPD59_RS13260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPD59_RS13265	COG0511	ligase activity, forming carbon-carbon bonds
EPD59_RS13270	COG0439	Biotin carboxylase
EPD59_RS13280	COG0210	DNA helicase
EPD59_RS13290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPD59_RS13295	COG1950	PFAM Membrane protein of
EPD59_RS13300	COG0010	Belongs to the arginase family
EPD59_RS13305	COG1776	CheC inhibitor of MCP methylation
EPD59_RS13310	COG0643	Histidine kinase
EPD59_RS13310	COG2198	Histidine kinase
EPD59_RS13315	COG2201	protein-glutamate methylesterase activity
EPD59_RS13320	COG2201	protein-glutamate methylesterase activity
EPD59_RS13325	COG0835	chemotaxis
EPD59_RS13345	COG1754	DNA topoisomerase type I activity
EPD59_RS13345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPD59_RS13360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPD59_RS13370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPD59_RS13375	COG0187	DNA topoisomerase II activity
EPD59_RS13395	COG2755	lipolytic protein G-D-S-L family
EPD59_RS13395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPD59_RS13415	COG2304	oxidoreductase activity
EPD59_RS13425	COG0183	Belongs to the thiolase family
EPD59_RS13460	COG0124	histidyl-tRNA synthetase
EPD59_RS13465	COG2986	histidine ammonia-lyase
EPD59_RS13475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EPD59_RS13495	COG0022	dehydrogenase e1 component
EPD59_RS13495	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPD59_RS13530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPD59_RS13550	COG0590	tRNA wobble adenosine to inosine editing
EPD59_RS13555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPD59_RS13570	COG1086	Polysaccharide biosynthesis protein
EPD59_RS13575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPD59_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS13590	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
EPD59_RS13600	COG2089	acid synthase
EPD59_RS13635	COG0531	amino acid
EPD59_RS13665	COG2884	Cell division ATP-binding protein ftsE
EPD59_RS13675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPD59_RS13690	COG0519	Catalyzes the synthesis of GMP from XMP
EPD59_RS13690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPD59_RS13710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPD59_RS13760	COG1131	(ABC) transporter
EPD59_RS13765	COG4221	oxidoreductase activity
EPD59_RS13780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPD59_RS13800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EPD59_RS13805	COG2086	electron transfer activity
EPD59_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS13865	COG0415	Belongs to the DNA photolyase family
EPD59_RS13885	COG3186	Phenylalanine-4-hydroxylase
EPD59_RS13900	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EPD59_RS13905	COG0159	tryptophan synthase activity
EPD59_RS13915	COG0135	phosphoribosylanthranilate isomerase activity
EPD59_RS13920	COG0134	indole-3-glycerol-phosphate synthase activity
EPD59_RS13925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPD59_RS13940	COG2819	hydrolase of the alpha beta superfamily
EPD59_RS13960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPD59_RS13975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPD59_RS13990	COG4771	TonB-dependent receptor
EPD59_RS14000	COG4771	TonB-dependent receptor
EPD59_RS14015	COG1404	Belongs to the peptidase S8 family
EPD59_RS14025	COG2204	response regulator
EPD59_RS14040	COG0022	dehydrogenase e1 component
EPD59_RS14050	COG0686	Belongs to the AlaDH PNT family
EPD59_RS14060	COG1368	sulfuric ester hydrolase activity
EPD59_RS14070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPD59_RS14075	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EPD59_RS14080	COG2318	DinB family
EPD59_RS14100	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EPD59_RS14135	COG4771	TonB-dependent receptor
EPD59_RS14140	COG4771	TonB-dependent receptor
EPD59_RS14145	COG0702	epimerase
EPD59_RS14160	COG1069	ribulokinase activity
EPD59_RS14170	COG2160	L-arabinose isomerase activity
EPD59_RS14190	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD59_RS14195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPD59_RS14200	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD59_RS14205	COG1609	Transcriptional regulator
EPD59_RS14245	COG2755	lipolytic protein G-D-S-L family
EPD59_RS14280	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EPD59_RS14305	COG0702	epimerase
EPD59_RS14310	COG1629	transport
EPD59_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS14320	COG3347	Dehydrogenase
EPD59_RS14330	COG4952	isomerase
EPD59_RS14340	COG0247	lactate metabolic process
EPD59_RS14350	COG1556	Lactate utilization protein
EPD59_RS14375	COG1629	transport
EPD59_RS14380	COG1629	transport
EPD59_RS14385	COG1629	transport
EPD59_RS14395	COG3254	rhamnose metabolic process
EPD59_RS14425	COG0726	polysaccharide deacetylase
EPD59_RS14425	COG1649	PFAM Uncharacterised BCR, COG1649
EPD59_RS14440	COG2304	oxidoreductase activity
EPD59_RS14460	COG3852	Histidine kinase
EPD59_RS14480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPD59_RS14485	COG0702	epimerase
EPD59_RS14490	COG1733	regulation of RNA biosynthetic process
EPD59_RS14500	COG1472	Belongs to the glycosyl hydrolase 3 family
EPD59_RS14520	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EPD59_RS14525	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EPD59_RS14535	COG3852	Histidine kinase
EPD59_RS14540	COG3852	Histidine kinase
EPD59_RS14580	COG1473	amidohydrolase
EPD59_RS14615	COG3279	Response regulator of the LytR AlgR family
EPD59_RS14620	COG2072	flavoprotein involved in K transport
EPD59_RS14640	COG2852	Protein conserved in bacteria
EPD59_RS14660	COG0277	FAD linked oxidase domain protein
EPD59_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS14690	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPD59_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS14705	COG3852	Histidine kinase
EPD59_RS14720	COG1629	transport
EPD59_RS14720	COG4206	TonB-dependent receptor
EPD59_RS14725	COG1629	transport
EPD59_RS14730	COG4771	TonB-dependent receptor
EPD59_RS14750	COG1368	sulfuric ester hydrolase activity
EPD59_RS14765	COG0252	asparaginase activity
EPD59_RS14770	COG0084	hydrolase, TatD family'
EPD59_RS14780	COG0726	polysaccharide deacetylase
EPD59_RS14835	COG0463	Glycosyl transferase, family 2
EPD59_RS14845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EPD59_RS14885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPD59_RS14890	COG1335	isochorismatase
EPD59_RS14905	COG0579	oxidoreductase
EPD59_RS14945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPD59_RS14955	COG3279	Response regulator of the LytR AlgR family
EPD59_RS14960	COG3275	phosphorelay sensor kinase activity
EPD59_RS14965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD59_RS14970	COG0217	transcriptional regulatory protein
EPD59_RS14980	COG4682	membrane
EPD59_RS14985	COG1187	pseudouridine synthase activity
EPD59_RS14990	COG0110	maltose O-acetyltransferase activity
EPD59_RS14995	COG1714	RDD family
EPD59_RS15005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPD59_RS15010	COG0156	8-amino-7-oxononanoate synthase activity
EPD59_RS15065	COG1082	Xylose isomerase domain protein TIM barrel
EPD59_RS15070	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPD59_RS15085	COG0527	aspartate kinase activity
EPD59_RS15090	COG0019	diaminopimelate decarboxylase activity
EPD59_RS15095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPD59_RS15100	COG0702	epimerase
EPD59_RS15115	COG1064	alcohol dehydrogenase
EPD59_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS15125	COG0288	reversible hydration of carbon dioxide
EPD59_RS15130	COG0659	secondary active sulfate transmembrane transporter activity
EPD59_RS15150	COG0489	protein tyrosine kinase activity
EPD59_RS15185	COG0438	transferase activity, transferring glycosyl groups
EPD59_RS15185	COG0297	glycogen (starch) synthase activity
EPD59_RS15190	COG1216	Glycosyl transferase, family 2
EPD59_RS15190	COG0463	Glycosyl transferase, family 2
EPD59_RS15205	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EPD59_RS15210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS15220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPD59_RS15225	COG4310	Domain of unknown function (DUF2172)
EPD59_RS15235	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EPD59_RS15245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EPD59_RS15250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EPD59_RS15260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPD59_RS15265	COG0363	glucosamine-6-phosphate deaminase activity
EPD59_RS15275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPD59_RS15290	COG3290	protein histidine kinase activity
EPD59_RS15315	COG3973	AAA domain
EPD59_RS15320	COG2080	2 iron, 2 sulfur cluster binding
EPD59_RS15325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EPD59_RS15330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPD59_RS15340	COG1011	Hydrolase
EPD59_RS15360	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPD59_RS15380	COG1846	Transcriptional regulator
EPD59_RS15385	COG1764	response to oxidative stress
EPD59_RS15390	COG0514	ATP-dependent DNA helicase (RecQ)
EPD59_RS15400	COG1136	(ABC) transporter
EPD59_RS15410	COG0045	succinate-CoA ligase (ADP-forming) activity
EPD59_RS15415	COG1764	response to oxidative stress
EPD59_RS15435	COG2197	response regulator
EPD59_RS15445	COG0494	nUDIX hydrolase
EPD59_RS15460	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD59_RS15550	COG3275	phosphorelay sensor kinase activity
EPD59_RS15555	COG3279	Response regulator of the LytR AlgR family
EPD59_RS15560	COG1012	belongs to the aldehyde dehydrogenase family
EPD59_RS15570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPD59_RS15625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPD59_RS15630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPD59_RS15645	COG1053	succinate dehydrogenase
EPD59_RS15660	COG0038	chloride channel
EPD59_RS15670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPD59_RS15685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPD59_RS15690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPD59_RS15700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPD59_RS15705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPD59_RS15715	COG0768	penicillin binding
EPD59_RS15725	COG0275	rRNA processing
EPD59_RS15730	COG2001	Belongs to the MraZ family
EPD59_RS15755	COG3279	Response regulator of the LytR AlgR family
EPD59_RS15760	COG2205	protein histidine kinase activity
EPD59_RS15760	COG2202	Pas domain
EPD59_RS15770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPD59_RS15790	COG1233	COG1233 Phytoene dehydrogenase and related
EPD59_RS15795	COG1595	DNA-templated transcription, initiation
EPD59_RS15815	COG0658	competence protein
EPD59_RS15815	COG2333	competence protein COMEC
EPD59_RS15825	COG1702	phosphate starvation-inducible protein PhoH
EPD59_RS15860	COG0300	oxidoreductase activity
EPD59_RS15875	COG2197	response regulator
EPD59_RS15885	COG3665	Urea carboxylase-associated protein
EPD59_RS15910	COG0531	amino acid
EPD59_RS15920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD59_RS15925	COG0420	3'-5' exonuclease activity
EPD59_RS15935	COG0419	ATPase involved in DNA repair
EPD59_RS15940	COG0419	ATPase involved in DNA repair
EPD59_RS15965	COG3118	belongs to the thioredoxin family
EPD59_RS15980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EPD59_RS15990	COG0616	signal peptide processing
EPD59_RS15995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPD59_RS16005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPD59_RS16020	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS16060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPD59_RS16065	COG2095	MarC family integral membrane protein
EPD59_RS16070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPD59_RS16075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPD59_RS16075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPD59_RS16085	COG1215	transferase activity, transferring glycosyl groups
EPD59_RS16090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPD59_RS16135	COG1301	dicarboxylic acid transport
EPD59_RS16155	COG0671	phosphoesterase, PA-phosphatase related
EPD59_RS16165	COG0671	phosphoesterase, PA-phosphatase related
EPD59_RS16190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPD59_RS16210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPD59_RS16220	COG1132	(ABC) transporter
EPD59_RS16265	COG1428	Deoxynucleoside kinase
EPD59_RS16290	COG1228	amidohydrolase
EPD59_RS16320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPD59_RS16330	COG3590	peptidase
EPD59_RS16335	COG3590	peptidase
EPD59_RS16340	COG1570	exodeoxyribonuclease VII activity
EPD59_RS16345	COG1722	exodeoxyribonuclease VII activity
EPD59_RS16375	COG3685	Protein conserved in bacteria
EPD59_RS16385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPD59_RS16415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPD59_RS16430	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPD59_RS16465	COG0824	Thioesterase
EPD59_RS16470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPD59_RS16475	COG0009	L-threonylcarbamoyladenylate synthase
EPD59_RS16495	COG0542	response to heat
EPD59_RS16510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPD59_RS16520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPD59_RS16525	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EPD59_RS16545	COG0793	Belongs to the peptidase S41A family
EPD59_RS16555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPD59_RS16575	COG0662	Cupin 2, conserved barrel domain protein
EPD59_RS16575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPD59_RS16580	COG0412	Dienelactone hydrolase
EPD59_RS16625	COG4106	trans-aconitate 2-methyltransferase activity
EPD59_RS16695	COG0037	tRNA processing
EPD59_RS16700	COG0039	L-malate dehydrogenase activity
EPD59_RS16715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPD59_RS16720	COG1472	Belongs to the glycosyl hydrolase 3 family
EPD59_RS16725	COG0438	transferase activity, transferring glycosyl groups
EPD59_RS16740	COG0316	Belongs to the HesB IscA family
EPD59_RS16760	COG4152	abc transporter atp-binding protein
EPD59_RS16775	COG0484	heat shock protein binding
EPD59_RS16780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPD59_RS16790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPD59_RS16800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EPD59_RS16825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPD59_RS16845	COG1216	Glycosyl transferase, family 2
EPD59_RS16845	COG0463	Glycosyl transferase, family 2
EPD59_RS16860	COG1216	Glycosyl transferase, family 2
EPD59_RS16870	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EPD59_RS16875	COG1216	Glycosyl transferase, family 2
EPD59_RS16885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS16890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPD59_RS16915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPD59_RS16915	COG2755	lipolytic protein G-D-S-L family
EPD59_RS16940	COG0438	transferase activity, transferring glycosyl groups
EPD59_RS16965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS16985	COG0463	Glycosyl transferase, family 2
EPD59_RS17000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD59_RS17010	COG0367	asparagine synthase
EPD59_RS17020	COG0277	FAD linked oxidase domain protein
EPD59_RS17025	COG0791	NLP P60 protein
EPD59_RS17045	COG1045	serine acetyltransferase
EPD59_RS17055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPD59_RS17100	COG2814	Major facilitator Superfamily
EPD59_RS17140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EPD59_RS17155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPD59_RS17175	COG0571	ribonuclease III activity
EPD59_RS17180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPD59_RS17185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPD59_RS17195	COG0469	pyruvate kinase activity
EPD59_RS17200	COG0268	Binds directly to 16S ribosomal RNA
EPD59_RS17225	COG0343	queuine tRNA-ribosyltransferase activity
EPD59_RS17240	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EPD59_RS17245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPD59_RS17255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPD59_RS17280	COG3547	Transposase (IS116 IS110 IS902 family)
EPD59_RS17290	COG0110	maltose O-acetyltransferase activity
EPD59_RS17315	COG4221	oxidoreductase activity
EPD59_RS17320	COG0667	Aldo Keto reductase
EPD59_RS17325	COG3250	beta-galactosidase activity
EPD59_RS17330	COG3250	beta-galactosidase activity
EPD59_RS17335	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EPD59_RS17345	COG4771	TonB-dependent receptor
EPD59_RS17350	COG1609	Transcriptional regulator
EPD59_RS17355	COG0626	cystathionine gamma-synthase activity
EPD59_RS17365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPD59_RS17375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPD59_RS17380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPD59_RS17385	COG0193	aminoacyl-tRNA hydrolase activity
EPD59_RS17390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPD59_RS17390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPD59_RS17410	COG1217	gtp-binding protein TYPA
EPD59_RS17415	COG3361	conserved protein (COG2071)
EPD59_RS17430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPD59_RS17435	COG4251	negative regulation of phosphorylation
EPD59_RS17440	COG0784	Response regulator, receiver
EPD59_RS17450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPD59_RS17460	COG1872	DUF167
EPD59_RS17470	COG0004	ammonium transporteR
EPD59_RS17475	COG2234	aminopeptidase activity
EPD59_RS17480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPD59_RS17485	COG0583	DNA-binding transcription factor activity
EPD59_RS17535	COG4953	penicillin-binding protein 1C
EPD59_RS17555	COG1012	belongs to the aldehyde dehydrogenase family
EPD59_RS17560	COG2207	Transcriptional regulator
EPD59_RS17560	COG1917	Cupin 2, conserved barrel domain protein
EPD59_RS17575	COG0596	Alpha beta hydrolase
EPD59_RS17595	COG2996	Protein conserved in bacteria
EPD59_RS17600	COG0702	epimerase
EPD59_RS17620	COG3608	succinylglutamate desuccinylase aspartoacylase
EPD59_RS17625	COG0189	ligase activity
EPD59_RS17630	COG4067	protein conserved in archaea
EPD59_RS17630	COG0189	ligase activity
EPD59_RS17650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPD59_RS17655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPD59_RS17670	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EPD59_RS17675	COG3279	Response regulator of the LytR AlgR family
EPD59_RS17685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EPD59_RS17695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPD59_RS17710	COG2351	hydroxyisourate hydrolase activity
EPD59_RS17720	COG3257	ureidoglycine aminohydrolase activity
EPD59_RS17730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPD59_RS17740	COG3608	succinylglutamate desuccinylase aspartoacylase
EPD59_RS17740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EPD59_RS17745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPD59_RS17760	COG0702	epimerase
EPD59_RS17770	COG1418	mRNA catabolic process
EPD59_RS17795	COG2003	Belongs to the UPF0758 family
EPD59_RS17855	COG0612	Peptidase, M16
EPD59_RS17905	COG3852	Histidine kinase
EPD59_RS17965	COG0612	Peptidase, M16
EPD59_RS17970	COG0538	isocitrate dehydrogenase activity
EPD59_RS18000	COG0540	Belongs to the ATCase OTCase family
EPD59_RS18005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPD59_RS18015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPD59_RS18020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPD59_RS18035	COG0436	Aminotransferase
EPD59_RS18040	COG2814	Major facilitator Superfamily
EPD59_RS18045	COG1064	alcohol dehydrogenase
EPD59_RS18060	COG0702	epimerase
EPD59_RS18065	COG4771	TonB-dependent receptor
EPD59_RS18080	COG1515	deoxyribonuclease V activity
EPD59_RS18085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPD59_RS18095	COG2885	chlorophyll binding
EPD59_RS18115	COG1136	(ABC) transporter
EPD59_RS18125	COG0577	efflux transmembrane transporter activity
EPD59_RS18180	COG2326	polyphosphate kinase activity
EPD59_RS18185	COG1105	Belongs to the carbohydrate kinase PfkB family
EPD59_RS18195	COG1505	serine-type exopeptidase activity
EPD59_RS18200	COG2130	NADP-dependent
EPD59_RS18220	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS18260	COG2354	Protein conserved in bacteria
EPD59_RS18275	COG0542	response to heat
EPD59_RS18310	COG0745	RESPONSE REGULATOR receiver
EPD59_RS18315	COG5002	protein histidine kinase activity
EPD59_RS18340	COG0640	Transcriptional regulator
EPD59_RS18350	COG1011	Hydrolase
EPD59_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
EPD59_RS18365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD59_RS18375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD59_RS18380	COG0649	NAD binding
EPD59_RS18385	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EPD59_RS18400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EPD59_RS18405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD59_RS18415	COG1309	transcriptional regulator
EPD59_RS18420	COG1132	(ABC) transporter
EPD59_RS18440	COG1595	DNA-templated transcription, initiation
EPD59_RS18445	COG0713	ATP synthesis coupled electron transport
EPD59_RS18455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD59_RS18460	COG1007	ATP synthesis coupled electron transport
EPD59_RS18470	COG2885	chlorophyll binding
EPD59_RS18480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPD59_RS18485	COG1131	(ABC) transporter
EPD59_RS18505	COG0590	tRNA wobble adenosine to inosine editing
EPD59_RS18535	COG0105	UTP biosynthetic process
EPD59_RS18545	COG0545	Peptidyl-prolyl cis-trans isomerase
EPD59_RS18550	COG0545	Peptidyl-prolyl cis-trans isomerase
EPD59_RS18565	COG1381	Involved in DNA repair and RecF pathway recombination
EPD59_RS18595	COG0768	penicillin binding
EPD59_RS18615	COG0138	bifunctional purine biosynthesis protein purh
EPD59_RS18625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EPD59_RS18650	COG1278	Cold shock
EPD59_RS18655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EPD59_RS18665	COG0633	Ferredoxin
EPD59_RS18710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPD59_RS18720	COG1183	phosphatidylcholine synthase activity
EPD59_RS18740	COG0612	Peptidase, M16
EPD59_RS18770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPD59_RS18775	COG0531	amino acid
EPD59_RS18785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPD59_RS18795	COG0594	ribonuclease P activity
EPD59_RS18800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPD59_RS18820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPD59_RS18830	COG0513	Belongs to the DEAD box helicase family
EPD59_RS18840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPD59_RS18880	COG0167	dihydroorotate dehydrogenase activity
EPD59_RS18955	COG0702	epimerase
EPD59_RS18965	COG4771	TonB-dependent receptor
EPD59_RS18970	COG4771	TonB-dependent receptor
EPD59_RS18975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EPD59_RS18980	COG1085	galactose-1-phosphate uridylyltransferase
EPD59_RS18990	COG3940	Belongs to the glycosyl hydrolase 43 family
EPD59_RS19010	COG3940	Belongs to the glycosyl hydrolase 43 family
EPD59_RS19050	COG0149	triose-phosphate isomerase activity
EPD59_RS19080	COG1629	transport
EPD59_RS19085	COG4771	TonB-dependent receptor
EPD59_RS19090	COG0702	epimerase
EPD59_RS19110	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD59_RS19110	COG3693	PFAM glycoside hydrolase, family 10
EPD59_RS19110	COG2382	esterase
EPD59_RS19120	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS19125	COG1312	Catalyzes the dehydration of D-mannonate
EPD59_RS19160	COG1073	alpha beta
EPD59_RS19230	COG1530	ribonuclease E activity
EPD59_RS19240	COG0776	regulation of translation
EPD59_RS19275	COG1960	acyl-CoA dehydrogenase activity
EPD59_RS19285	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD59_RS19285	COG1024	Enoyl-CoA hydratase
EPD59_RS19295	COG1022	Amp-dependent synthetase and ligase
EPD59_RS19310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPD59_RS19325	COG1160	GTP binding
EPD59_RS19330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPD59_RS19335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPD59_RS19340	COG0730	response to heat
EPD59_RS19355	COG1104	cysteine desulfurase activity
EPD59_RS19360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPD59_RS19365	COG3956	TIGRFAM MazG family protein
EPD59_RS19390	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPD59_RS19415	COG0564	pseudouridine synthase activity
EPD59_RS19430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPD59_RS19435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPD59_RS19450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPD59_RS19485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPD59_RS19490	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EPD59_RS19510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPD59_RS19535	COG2885	chlorophyll binding
EPD59_RS19560	COG0753	catalase activity
EPD59_RS19565	COG0583	DNA-binding transcription factor activity
EPD59_RS19605	COG5002	protein histidine kinase activity
EPD59_RS19625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD59_RS19635	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS19645	COG0791	NLP P60 protein
EPD59_RS19655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPD59_RS19660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPD59_RS19675	COG1309	transcriptional regulator
EPD59_RS19685	COG2234	aminopeptidase activity
EPD59_RS19690	COG1139	Iron-sulfur cluster binding protein
EPD59_RS19715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPD59_RS19715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPD59_RS19745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPD59_RS19750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPD59_RS19755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPD59_RS19760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPD59_RS19765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPD59_RS19770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPD59_RS19775	COG0356	it plays a direct role in the translocation of protons across the membrane
EPD59_RS19800	COG0322	excinuclease ABC activity
EPD59_RS19820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPD59_RS19850	COG0321	lipoyl(octanoyl) transferase activity
EPD59_RS19855	COG0792	nuclease activity
EPD59_RS19865	COG0326	Molecular chaperone. Has ATPase activity
EPD59_RS19870	COG3693	PFAM glycoside hydrolase, family 10
EPD59_RS19885	COG4774	siderophore transport
EPD59_RS19900	COG2814	Major facilitator Superfamily
EPD59_RS19980	COG1704	LemA family
EPD59_RS20010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPD59_RS20010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPD59_RS20020	COG0492	ferredoxin-NADP+ reductase activity
EPD59_RS20050	COG0598	Magnesium transport protein CorA
EPD59_RS20060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EPD59_RS20070	COG3590	peptidase
EPD59_RS20095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPD59_RS20105	COG1131	(ABC) transporter
EPD59_RS20115	COG1725	Transcriptional regulator
EPD59_RS20135	COG2366	antibiotic biosynthetic process
EPD59_RS20145	COG1733	regulation of RNA biosynthetic process
EPD59_RS20155	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS20190	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPD59_RS20240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPD59_RS20250	COG0315	cyclic pyranopterin monophosphate synthase activity
EPD59_RS20260	COG0314	molybdopterin synthase activity
EPD59_RS20280	COG1073	alpha beta
EPD59_RS20305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPD59_RS20320	COG3655	Transcriptional regulator
EPD59_RS20370	COG1640	4-alpha-glucanotransferase
EPD59_RS20385	COG0492	ferredoxin-NADP+ reductase activity
EPD59_RS20390	COG3852	Histidine kinase
EPD59_RS20420	COG2115	Belongs to the xylose isomerase family
EPD59_RS20445	COG2382	esterase
EPD59_RS20445	COG3693	PFAM glycoside hydrolase, family 10
EPD59_RS20445	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD59_RS20455	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD59_RS20475	COG4771	TonB-dependent receptor
EPD59_RS20480	COG1028	Short-chain dehydrogenase reductase Sdr
EPD59_RS20485	COG3661	Belongs to the glycosyl hydrolase 67 family
EPD59_RS20490	COG1312	Catalyzes the dehydration of D-mannonate
EPD59_RS20495	COG1609	Transcriptional regulator
EPD59_RS20540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPD59_RS20560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EPD59_RS20565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPD59_RS20570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPD59_RS20575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPD59_RS20575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPD59_RS20600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPD59_RS20645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPD59_RS20650	COG0300	oxidoreductase activity
EPD59_RS20655	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPD59_RS20655	COG0596	Alpha beta hydrolase
EPD59_RS20660	COG1027	Aspartate ammonia-lyase
EPD59_RS20735	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD59_RS20740	COG0673	inositol 2-dehydrogenase activity
EPD59_RS20765	COG4628	conserved protein (DUF2132)
EPD59_RS20770	COG3757	hydrolase, family 25
EPD59_RS20810	COG2226	methyltransferase
EPD59_RS20840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPD59_RS20855	COG0432	Pfam Uncharacterised protein family UPF0047
EPD59_RS20865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPD59_RS20895	COG0612	Peptidase, M16
EPD59_RS20905	COG1215	transferase activity, transferring glycosyl groups
EPD59_RS20920	COG4221	oxidoreductase activity
EPD59_RS20945	COG0058	SHG alpha-glucan phosphorylase activity
EPD59_RS20965	COG1233	COG1233 Phytoene dehydrogenase and related
EPD59_RS20980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPD59_RS20985	COG0798	PFAM Bile acid sodium symporter
EPD59_RS20990	COG0346	lactoylglutathione lyase activity
EPD59_RS21000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPD59_RS21010	COG0531	amino acid
EPD59_RS21015	COG0456	acetyltransferase
EPD59_RS21045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD59_RS21055	COG0640	Transcriptional regulator
EPD59_RS21065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD59_RS21080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPD59_RS21085	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPD59_RS21110	COG0698	ribose 5-phosphate isomerase
EPD59_RS21115	COG0805	protein transport
EPD59_RS21120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPD59_RS21135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPD59_RS21150	COG2154	pterin-4-alpha-carbinolamine dehydratase
EPD59_RS21160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPD59_RS21170	COG0483	inositol monophosphate 1-phosphatase activity
EPD59_RS21220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPD59_RS21265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EPD59_RS21360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPD59_RS21360	COG0515	serine threonine protein kinase
EPD59_RS21365	COG1040	competence protein
EPD59_RS21385	COG0708	Exodeoxyribonuclease III
EPD59_RS21400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPD59_RS21405	COG0445	tRNA wobble uridine modification