locus-tag	class	description
GKZ67_RS00055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GKZ67_RS00080	COG1192	Involved in chromosome partitioning
GKZ67_RS00085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GKZ67_RS00090	COG0747	negative chemotaxis
GKZ67_RS00100	COG0706	membrane insertase activity
GKZ67_RS00110	COG0504	CTP synthase activity
GKZ67_RS00120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GKZ67_RS00125	COG0440	acetolactate synthase activity
GKZ67_RS00130	COG0028	Belongs to the TPP enzyme family
GKZ67_RS00135	COG0129	dihydroxy-acid dehydratase activity
GKZ67_RS00140	COG0473	3-isopropylmalate dehydrogenase activity
GKZ67_RS00145	COG0066	3-isopropylmalate dehydratase activity
GKZ67_RS00155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKZ67_RS00170	COG2027	D-alanyl-D-alanine carboxypeptidase
GKZ67_RS00210	COG0154	amidase activity
GKZ67_RS00215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKZ67_RS00225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKZ67_RS00230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GKZ67_RS00235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GKZ67_RS00240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GKZ67_RS00245	COG2080	2 iron, 2 sulfur cluster binding
GKZ67_RS00255	COG2130	NADP-dependent
GKZ67_RS00260	COG0667	Aldo Keto reductase
GKZ67_RS00280	COG0671	phosphoesterase, PA-phosphatase related
GKZ67_RS00285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GKZ67_RS00305	COG0248	Ppx GppA phosphatase
GKZ67_RS00310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GKZ67_RS00310	COG0116	Belongs to the methyltransferase superfamily
GKZ67_RS00330	COG0768	penicillin binding
GKZ67_RS00335	COG0768	penicillin binding
GKZ67_RS00340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GKZ67_RS00375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GKZ67_RS00385	COG1473	amidohydrolase
GKZ67_RS00445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKZ67_RS00460	COG1136	(ABC) transporter
GKZ67_RS00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKZ67_RS00480	COG4206	TonB-dependent receptor
GKZ67_RS00480	COG1629	transport
GKZ67_RS00490	COG1629	transport
GKZ67_RS00510	COG1629	transport
GKZ67_RS00515	COG4771	TonB-dependent receptor
GKZ67_RS00520	COG4771	TonB-dependent receptor
GKZ67_RS00525	COG0702	epimerase
GKZ67_RS00530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GKZ67_RS00540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GKZ67_RS00565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKZ67_RS00600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GKZ67_RS00605	COG0784	Response regulator, receiver
GKZ67_RS00610	COG4251	negative regulation of phosphorylation
GKZ67_RS00620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GKZ67_RS00625	COG2045	Belongs to the ComB family
GKZ67_RS00655	COG0531	amino acid
GKZ67_RS00675	COG2885	chlorophyll binding
GKZ67_RS00695	COG0628	permease
GKZ67_RS00730	COG3920	Histidine kinase
GKZ67_RS00775	COG2197	response regulator
GKZ67_RS00790	COG1295	ribonuclease BN
GKZ67_RS00870	COG5002	protein histidine kinase activity
GKZ67_RS00875	COG3437	response regulator, receiver
GKZ67_RS00945	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GKZ67_RS00960	COG1702	phosphate starvation-inducible protein PhoH
GKZ67_RS00965	COG2814	Major facilitator Superfamily
GKZ67_RS00975	COG0658	competence protein
GKZ67_RS00975	COG2333	competence protein COMEC
GKZ67_RS00985	COG1024	Enoyl-CoA hydratase
GKZ67_RS01005	COG1595	DNA-templated transcription, initiation
GKZ67_RS01025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GKZ67_RS01035	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GKZ67_RS01060	COG2382	esterase
GKZ67_RS01090	COG0702	epimerase
GKZ67_RS01095	COG4771	TonB-dependent receptor
GKZ67_RS01120	COG2001	Belongs to the MraZ family
GKZ67_RS01125	COG0275	rRNA processing
GKZ67_RS01135	COG0768	penicillin binding
GKZ67_RS01145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKZ67_RS01150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GKZ67_RS01155	COG0772	Belongs to the SEDS family
GKZ67_RS01160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GKZ67_RS01165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKZ67_RS01190	COG1858	cytochrome C peroxidase
GKZ67_RS01195	COG1858	cytochrome C peroxidase
GKZ67_RS01210	COG4771	TonB-dependent receptor
GKZ67_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS01255	COG0019	diaminopimelate decarboxylase activity
GKZ67_RS01265	COG1902	pentaerythritol trinitrate reductase activity
GKZ67_RS01290	COG0077	Prephenate dehydratase
GKZ67_RS01295	COG0436	Aminotransferase
GKZ67_RS01305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GKZ67_RS01315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKZ67_RS01330	COG2814	Major facilitator Superfamily
GKZ67_RS01335	COG3590	peptidase
GKZ67_RS01350	COG0714	Associated with various cellular activities
GKZ67_RS01390	COG0776	regulation of translation
GKZ67_RS01410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GKZ67_RS01430	COG1960	acyl-CoA dehydrogenase activity
GKZ67_RS01440	COG0183	Belongs to the thiolase family
GKZ67_RS01445	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKZ67_RS01445	COG1024	Enoyl-CoA hydratase
GKZ67_RS01455	COG1022	Amp-dependent synthetase and ligase
GKZ67_RS01465	COG0010	Belongs to the arginase family
GKZ67_RS01475	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GKZ67_RS01495	COG1160	GTP binding
GKZ67_RS01500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GKZ67_RS01505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GKZ67_RS01565	COG0159	tryptophan synthase activity
GKZ67_RS01570	COG0133	tryptophan synthase activity
GKZ67_RS01575	COG0135	phosphoribosylanthranilate isomerase activity
GKZ67_RS01580	COG0134	indole-3-glycerol-phosphate synthase activity
GKZ67_RS01585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GKZ67_RS01590	COG0512	Glutamine amidotransferase of anthranilate synthase
GKZ67_RS01590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GKZ67_RS01595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GKZ67_RS01620	COG0632	four-way junction helicase activity
GKZ67_RS01630	COG0596	Alpha beta hydrolase
GKZ67_RS01645	COG2814	Major facilitator Superfamily
GKZ67_RS01670	COG2207	Transcriptional regulator
GKZ67_RS01675	COG1012	belongs to the aldehyde dehydrogenase family
GKZ67_RS01695	COG4953	penicillin-binding protein 1C
GKZ67_RS01705	COG0799	negative regulation of ribosome biogenesis
GKZ67_RS01710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GKZ67_RS01715	COG1556	Lactate utilization protein
GKZ67_RS01755	COG1774	PSP1 C-terminal conserved region
GKZ67_RS01765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKZ67_RS01775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GKZ67_RS01785	COG2197	response regulator
GKZ67_RS01790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GKZ67_RS01805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKZ67_RS01820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GKZ67_RS01845	COG0189	ligase activity
GKZ67_RS01845	COG4067	protein conserved in archaea
GKZ67_RS01870	COG0604	alcohol dehydrogenase
GKZ67_RS01875	COG0705	Rhomboid family
GKZ67_RS01900	COG1649	PFAM Uncharacterised BCR, COG1649
GKZ67_RS01915	COG0702	epimerase
GKZ67_RS02005	COG0463	Glycosyl transferase, family 2
GKZ67_RS02035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKZ67_RS02040	COG0386	Belongs to the glutathione peroxidase family
GKZ67_RS02045	COG1575	Belongs to the MenA family. Type 1 subfamily
GKZ67_RS02060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GKZ67_RS02120	COG1408	metallophosphoesterase
GKZ67_RS02130	COG2003	Belongs to the UPF0758 family
GKZ67_RS02155	COG1418	mRNA catabolic process
GKZ67_RS02170	COG0367	asparagine synthase
GKZ67_RS02205	COG0463	Glycosyl transferase, family 2
GKZ67_RS02235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GKZ67_RS02275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GKZ67_RS02275	COG2755	lipolytic protein G-D-S-L family
GKZ67_RS02325	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKZ67_RS02330	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GKZ67_RS02330	COG0037	tRNA processing
GKZ67_RS02335	COG0563	adenylate kinase activity
GKZ67_RS02340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GKZ67_RS02360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GKZ67_RS02380	COG4152	abc transporter atp-binding protein
GKZ67_RS02400	COG0671	phosphoesterase, PA-phosphatase related
GKZ67_RS02450	COG1472	Belongs to the glycosyl hydrolase 3 family
GKZ67_RS02455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GKZ67_RS02460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GKZ67_RS02485	COG1595	DNA-templated transcription, initiation
GKZ67_RS02490	COG0713	ATP synthesis coupled electron transport
GKZ67_RS02505	COG1064	alcohol dehydrogenase
GKZ67_RS02540	COG0402	S-adenosylhomocysteine deaminase activity
GKZ67_RS02570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GKZ67_RS02575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GKZ67_RS02580	COG2153	protein acetylation
GKZ67_RS02645	COG4677	pectinesterase activity
GKZ67_RS02695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GKZ67_RS02705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GKZ67_RS02715	COG2318	DinB family
GKZ67_RS02720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GKZ67_RS02725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GKZ67_RS02740	COG0686	Belongs to the AlaDH PNT family
GKZ67_RS02760	COG0022	dehydrogenase e1 component
GKZ67_RS02785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GKZ67_RS02860	COG2081	HI0933 family
GKZ67_RS02885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKZ67_RS02890	COG0527	aspartate kinase activity
GKZ67_RS02910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GKZ67_RS02915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GKZ67_RS02980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKZ67_RS02980	COG4499	WXG100 protein secretion system (Wss), protein YukC
GKZ67_RS03070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GKZ67_RS03080	COG0166	Belongs to the GPI family
GKZ67_RS03085	COG0166	Belongs to the GPI family
GKZ67_RS03095	COG2986	histidine ammonia-lyase
GKZ67_RS03110	COG0124	histidyl-tRNA synthetase
GKZ67_RS03135	COG0702	epimerase
GKZ67_RS03170	COG0217	transcriptional regulatory protein
GKZ67_RS03175	COG2205	protein histidine kinase activity
GKZ67_RS03175	COG2202	Pas domain
GKZ67_RS03180	COG3279	Response regulator of the LytR AlgR family
GKZ67_RS03220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKZ67_RS03240	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GKZ67_RS03250	COG1335	isochorismatase
GKZ67_RS03255	COG0579	oxidoreductase
GKZ67_RS03265	COG1278	Cold shock
GKZ67_RS03285	COG3279	Response regulator of the LytR AlgR family
GKZ67_RS03300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GKZ67_RS03320	COG1523	belongs to the glycosyl hydrolase 13 family
GKZ67_RS03325	COG1523	belongs to the glycosyl hydrolase 13 family
GKZ67_RS03335	COG2205	protein histidine kinase activity
GKZ67_RS03340	COG2202	Pas domain
GKZ67_RS03340	COG2205	protein histidine kinase activity
GKZ67_RS03370	COG2885	chlorophyll binding
GKZ67_RS03420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GKZ67_RS03460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GKZ67_RS03485	COG1476	TRANSCRIPTIONal
GKZ67_RS03525	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GKZ67_RS03530	COG4251	negative regulation of phosphorylation
GKZ67_RS03535	COG4251	negative regulation of phosphorylation
GKZ67_RS03540	COG4251	negative regulation of phosphorylation
GKZ67_RS03560	COG0667	Aldo Keto reductase
GKZ67_RS03570	COG1609	Transcriptional regulator
GKZ67_RS03620	COG1741	Belongs to the pirin family
GKZ67_RS03625	COG1741	Belongs to the pirin family
GKZ67_RS03655	COG0561	phosphatase activity
GKZ67_RS03660	COG4771	TonB-dependent receptor
GKZ67_RS03675	COG3275	phosphorelay sensor kinase activity
GKZ67_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS03700	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GKZ67_RS03715	COG1285	pathogenesis
GKZ67_RS03725	COG3279	Response regulator of the LytR AlgR family
GKZ67_RS03730	COG3275	phosphorelay sensor kinase activity
GKZ67_RS03740	COG3265	gluconokinase activity
GKZ67_RS03765	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GKZ67_RS03780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKZ67_RS03795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GKZ67_RS03800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GKZ67_RS03805	COG2080	2 iron, 2 sulfur cluster binding
GKZ67_RS03810	COG0460	homoserine dehydrogenase
GKZ67_RS03825	COG0673	inositol 2-dehydrogenase activity
GKZ67_RS03915	COG0045	succinate-CoA ligase (ADP-forming) activity
GKZ67_RS03920	COG1136	(ABC) transporter
GKZ67_RS03985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GKZ67_RS04025	COG2226	methyltransferase
GKZ67_RS04040	COG1215	transferase activity, transferring glycosyl groups
GKZ67_RS04050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKZ67_RS04055	COG0463	Glycosyl transferase, family 2
GKZ67_RS04095	COG4654	Cytochrome c, class I
GKZ67_RS04105	COG0673	inositol 2-dehydrogenase activity
GKZ67_RS04125	COG2610	gluconate transmembrane transporter activity
GKZ67_RS04130	COG1609	Transcriptional regulator
GKZ67_RS04130	COG2207	Transcriptional regulator
GKZ67_RS04170	COG5001	Diguanylate cyclase
GKZ67_RS04275	COG1597	lipid kinase activity
GKZ67_RS04310	COG1695	Transcriptional regulator
GKZ67_RS04390	COG1690	Belongs to the RtcB family
GKZ67_RS04405	COG0783	Belongs to the Dps family
GKZ67_RS04425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GKZ67_RS04425	COG0321	lipoyl(octanoyl) transferase activity
GKZ67_RS04430	COG2205	protein histidine kinase activity
GKZ67_RS04430	COG0784	Response regulator, receiver
GKZ67_RS04445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKZ67_RS04450	COG0205	6-phosphofructokinase activity
GKZ67_RS04475	COG1595	DNA-templated transcription, initiation
GKZ67_RS04490	COG2318	DinB family
GKZ67_RS04515	COG0538	isocitrate dehydrogenase activity
GKZ67_RS04520	COG0612	Peptidase, M16
GKZ67_RS04525	COG0300	oxidoreductase activity
GKZ67_RS04530	COG0513	Belongs to the DEAD box helicase family
GKZ67_RS04535	COG2226	methyltransferase
GKZ67_RS04590	COG3186	Phenylalanine-4-hydroxylase
GKZ67_RS04620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GKZ67_RS04625	COG0616	signal peptide processing
GKZ67_RS04635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GKZ67_RS04650	COG3118	belongs to the thioredoxin family
GKZ67_RS04670	COG0084	hydrolase, TatD family'
GKZ67_RS04675	COG0252	asparaginase activity
GKZ67_RS04700	COG0436	Aminotransferase
GKZ67_RS04710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GKZ67_RS04725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKZ67_RS04740	COG5002	protein histidine kinase activity
GKZ67_RS04775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKZ67_RS04835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKZ67_RS04840	COG0300	oxidoreductase activity
GKZ67_RS04850	COG4221	oxidoreductase activity
GKZ67_RS04890	COG1845	cytochrome c oxidase, subunit III
GKZ67_RS04995	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GKZ67_RS05020	COG1090	epimerase
GKZ67_RS05025	COG0302	gtp cyclohydrolase
GKZ67_RS05070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GKZ67_RS05085	COG1301	dicarboxylic acid transport
GKZ67_RS05095	COG2315	Protein conserved in bacteria
GKZ67_RS05125	COG0495	leucyl-tRNA aminoacylation
GKZ67_RS05130	COG0495	leucyl-tRNA aminoacylation
GKZ67_RS05135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKZ67_RS05140	COG0358	DNA primase activity
GKZ67_RS05145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GKZ67_RS05165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKZ67_RS05165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKZ67_RS05175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GKZ67_RS05185	COG0598	Magnesium transport protein CorA
GKZ67_RS05205	COG1216	Glycosyl transferase, family 2
GKZ67_RS05220	COG3011	Protein conserved in bacteria
GKZ67_RS05255	COG0667	Aldo Keto reductase
GKZ67_RS05305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKZ67_RS05305	COG1703	isobutyryl-CoA mutase activity
GKZ67_RS05305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKZ67_RS05325	COG0481	GTPase activity
GKZ67_RS05340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GKZ67_RS05345	COG0602	queuosine metabolic process
GKZ67_RS05350	COG3047	cAMP biosynthetic process
GKZ67_RS05350	COG2885	chlorophyll binding
GKZ67_RS05365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GKZ67_RS05410	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKZ67_RS05430	COG0488	(ABC) transporter
GKZ67_RS05465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GKZ67_RS05505	COG1131	(ABC) transporter
GKZ67_RS05510	COG0318	PFAM AMP-dependent synthetase and ligase
GKZ67_RS05515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GKZ67_RS05535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GKZ67_RS05550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GKZ67_RS05555	COG4974	Belongs to the 'phage' integrase family
GKZ67_RS05570	COG1674	ftsk spoiiie
GKZ67_RS05615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GKZ67_RS05635	COG0525	valine-tRNA ligase activity
GKZ67_RS05640	COG1073	alpha beta
GKZ67_RS05655	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKZ67_RS05700	COG0183	Belongs to the thiolase family
GKZ67_RS05710	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKZ67_RS05715	COG1024	Enoyl-CoA hydratase
GKZ67_RS05720	COG2151	metal-sulfur cluster biosynthetic enzyme
GKZ67_RS05725	COG3396	Phenylacetate-CoA oxygenase
GKZ67_RS05730	COG3460	Phenylacetate-CoA oxygenase
GKZ67_RS05735	COG3396	Phenylacetate-CoA oxygenase
GKZ67_RS05740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GKZ67_RS05770	COG0346	lactoylglutathione lyase activity
GKZ67_RS05780	COG0798	PFAM Bile acid sodium symporter
GKZ67_RS05785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKZ67_RS05790	COG0753	catalase activity
GKZ67_RS05810	COG1090	epimerase
GKZ67_RS05820	COG1546	Belongs to the CinA family
GKZ67_RS05820	COG1058	Belongs to the CinA family
GKZ67_RS05840	COG1131	(ABC) transporter
GKZ67_RS05850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GKZ67_RS05850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GKZ67_RS05855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GKZ67_RS05970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKZ67_RS05980	COG2326	polyphosphate kinase activity
GKZ67_RS06005	COG0488	(ABC) transporter
GKZ67_RS06065	COG3158	transport of potassium into the cell
GKZ67_RS06095	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKZ67_RS06100	COG3218	ABC-type transport auxiliary lipoprotein component
GKZ67_RS06100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GKZ67_RS06140	COG0028	Belongs to the TPP enzyme family
GKZ67_RS06170	COG3599	regulation of cell shape
GKZ67_RS06175	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GKZ67_RS06250	COG0545	Peptidyl-prolyl cis-trans isomerase
GKZ67_RS06275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GKZ67_RS06300	COG2755	lipolytic protein G-D-S-L family
GKZ67_RS06305	COG0335	large ribosomal subunit rRNA binding
GKZ67_RS06315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GKZ67_RS06320	COG0228	four-way junction DNA binding
GKZ67_RS06335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GKZ67_RS06345	COG3942	CHAP domain
GKZ67_RS06345	COG1388	LysM domain
GKZ67_RS06365	COG0612	Peptidase, M16
GKZ67_RS06375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GKZ67_RS06380	COG1984	allophanate hydrolase subunit 2
GKZ67_RS06385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GKZ67_RS06390	COG1914	H( )-stimulated, divalent metal cation uptake system
GKZ67_RS06400	COG0039	L-malate dehydrogenase activity
GKZ67_RS06415	COG0037	tRNA processing
GKZ67_RS06425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKZ67_RS06450	COG0497	DNA recombination
GKZ67_RS06455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GKZ67_RS06460	COG0300	oxidoreductase activity
GKZ67_RS06470	COG0569	domain protein
GKZ67_RS06480	COG0412	Dienelactone hydrolase
GKZ67_RS06485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GKZ67_RS06495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKZ67_RS06500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GKZ67_RS06535	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GKZ67_RS06540	COG3104	oligopeptide transport
GKZ67_RS06545	COG0459	protein refolding
GKZ67_RS06550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GKZ67_RS06580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKZ67_RS06585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GKZ67_RS06615	COG1663	tetraacyldisaccharide 4'-kinase activity
GKZ67_RS06620	COG1663	tetraacyldisaccharide 4'-kinase activity
GKZ67_RS06640	COG0802	atpase or kinase
GKZ67_RS06645	COG0686	Belongs to the AlaDH PNT family
GKZ67_RS06655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GKZ67_RS06690	COG0745	RESPONSE REGULATOR receiver
GKZ67_RS06695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GKZ67_RS06710	COG0489	protein tyrosine kinase activity
GKZ67_RS06720	COG3250	beta-galactosidase activity
GKZ67_RS06760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKZ67_RS06760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKZ67_RS06770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKZ67_RS06770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKZ67_RS06785	COG0737	Belongs to the 5'-nucleotidase family
GKZ67_RS06800	COG2204	response regulator
GKZ67_RS06810	COG0577	efflux transmembrane transporter activity
GKZ67_RS06820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKZ67_RS06870	COG5002	protein histidine kinase activity
GKZ67_RS06875	COG2204	response regulator
GKZ67_RS06885	COG0662	Cupin 2, conserved barrel domain protein
GKZ67_RS06885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GKZ67_RS06900	COG1764	response to oxidative stress
GKZ67_RS06905	COG1846	Transcriptional regulator
GKZ67_RS06965	COG1607	acyl-coa hydrolase
GKZ67_RS06970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GKZ67_RS06975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GKZ67_RS07035	COG1760	l-serine dehydratase
GKZ67_RS07065	COG0628	permease
GKZ67_RS07100	COG0288	reversible hydration of carbon dioxide
GKZ67_RS07105	COG0642	Histidine kinase
GKZ67_RS07105	COG3850	Histidine kinase
GKZ67_RS07110	COG0745	RESPONSE REGULATOR receiver
GKZ67_RS07140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GKZ67_RS07145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GKZ67_RS07150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GKZ67_RS07170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GKZ67_RS07175	COG1185	polyribonucleotide nucleotidyltransferase activity
GKZ67_RS07180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKZ67_RS07185	COG0492	ferredoxin-NADP+ reductase activity
GKZ67_RS07190	COG1196	nuclear chromosome segregation
GKZ67_RS07190	COG0741	lytic transglycosylase activity
GKZ67_RS07190	COG0739	heme binding
GKZ67_RS07200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKZ67_RS07205	COG3158	transport of potassium into the cell
GKZ67_RS07260	COG2160	L-arabinose isomerase activity
GKZ67_RS07265	COG2223	nitrite transmembrane transporter activity
GKZ67_RS07270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GKZ67_RS07275	COG1609	Transcriptional regulator
GKZ67_RS07285	COG0439	Biotin carboxylase
GKZ67_RS07330	COG4682	membrane
GKZ67_RS07370	COG0517	IMP dehydrogenase activity
GKZ67_RS07370	COG1125	glycine betaine transport
GKZ67_RS07400	COG0811	peptide transport
GKZ67_RS07405	COG0848	biopolymer transport protein
GKZ67_RS07420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GKZ67_RS07430	COG0482	sulfurtransferase activity
GKZ67_RS07500	COG0667	Aldo Keto reductase
GKZ67_RS07505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GKZ67_RS07515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKZ67_RS07525	COG0758	DNA mediated transformation
GKZ67_RS07550	COG0657	acetylesterase activity
GKZ67_RS07550	COG2755	lipolytic protein G-D-S-L family
GKZ67_RS07580	COG2801	Transposase and inactivated derivatives
GKZ67_RS07585	COG2267	carboxylic ester hydrolase activity
GKZ67_RS07620	COG4134	Bacterial extracellular solute-binding protein
GKZ67_RS07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKZ67_RS07645	COG0415	Belongs to the DNA photolyase family
GKZ67_RS07660	COG1228	amidohydrolase
GKZ67_RS07680	COG1678	Uncharacterized ACR, COG1678
GKZ67_RS07745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GKZ67_RS07780	COG0140	phosphoribosyl-ATP diphosphatase activity
GKZ67_RS07780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GKZ67_RS07785	COG0346	lactoylglutathione lyase activity
GKZ67_RS07795	COG1011	Hydrolase
GKZ67_RS07800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GKZ67_RS07810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GKZ67_RS07810	COG0131	Imidazoleglycerol-phosphate dehydratase
GKZ67_RS07815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GKZ67_RS07825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GKZ67_RS07850	COG2072	flavoprotein involved in K transport
GKZ67_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS07865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GKZ67_RS07875	COG0588	phosphoglycerate mutase activity
GKZ67_RS07890	COG0477	Major facilitator Superfamily
GKZ67_RS07930	COG1473	amidohydrolase
GKZ67_RS07940	COG0242	peptide deformylase activity
GKZ67_RS07965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKZ67_RS08000	COG4680	protein conserved in bacteria
GKZ67_RS08015	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GKZ67_RS08030	COG1047	Peptidyl-prolyl cis-trans
GKZ67_RS08105	COG3158	transport of potassium into the cell
GKZ67_RS08125	COG0791	NLP P60 protein
GKZ67_RS08170	COG1845	cytochrome c oxidase, subunit III
GKZ67_RS08185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GKZ67_RS08220	COG2115	Belongs to the xylose isomerase family
GKZ67_RS08245	COG4771	TonB-dependent receptor
GKZ67_RS08255	COG3661	Belongs to the glycosyl hydrolase 67 family
GKZ67_RS08265	COG1609	Transcriptional regulator
GKZ67_RS08275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKZ67_RS08285	COG0247	lactate metabolic process
GKZ67_RS08295	COG0739	heme binding
GKZ67_RS08295	COG0741	lytic transglycosylase activity
GKZ67_RS08295	COG1196	nuclear chromosome segregation
GKZ67_RS08325	COG1360	Flagellar Motor Protein
GKZ67_RS08350	COG5002	protein histidine kinase activity
GKZ67_RS08385	COG0531	amino acid
GKZ67_RS08390	COG1629	transport
GKZ67_RS08430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GKZ67_RS08455	COG1741	Belongs to the pirin family
GKZ67_RS08490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKZ67_RS08495	COG1950	PFAM Membrane protein of
GKZ67_RS08500	COG0010	Belongs to the arginase family
GKZ67_RS08515	COG2201	protein-glutamate methylesterase activity
GKZ67_RS08520	COG0835	chemotaxis
GKZ67_RS08525	COG0840	transmembrane signaling receptor activity
GKZ67_RS08550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GKZ67_RS08560	COG4221	oxidoreductase activity
GKZ67_RS08570	COG2226	methyltransferase
GKZ67_RS08580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GKZ67_RS08585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GKZ67_RS08600	COG0460	homoserine dehydrogenase
GKZ67_RS08600	COG0527	aspartate kinase activity
GKZ67_RS08605	COG0450	alkyl hydroperoxide reductase
GKZ67_RS08615	COG1162	GTPase activity
GKZ67_RS08625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GKZ67_RS08630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKZ67_RS08680	COG2723	6-phospho-beta-galactosidase activity
GKZ67_RS08710	COG0513	Belongs to the DEAD box helicase family
GKZ67_RS08785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GKZ67_RS08800	COG3339	Conserved Protein
GKZ67_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS08820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKZ67_RS08825	COG2081	HI0933 family
GKZ67_RS08855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKZ67_RS08905	COG0501	Belongs to the peptidase M48B family
GKZ67_RS08950	COG1752	Esterase of the alpha-beta hydrolase superfamily
GKZ67_RS08955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKZ67_RS08960	COG0825	malonyl-CoA metabolic process
GKZ67_RS09010	COG5006	permease, DMT superfamily
GKZ67_RS09015	COG0793	Belongs to the peptidase S41A family
GKZ67_RS09025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GKZ67_RS09035	COG0513	Belongs to the DEAD box helicase family
GKZ67_RS09040	COG1278	Cold shock
GKZ67_RS09075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GKZ67_RS09080	COG0633	Ferredoxin
GKZ67_RS09080	COG3217	Mosc domain protein beta barrel domain protein
GKZ67_RS09095	COG1428	Deoxynucleoside kinase
GKZ67_RS09145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKZ67_RS09160	COG3590	peptidase
GKZ67_RS09165	COG3590	peptidase
GKZ67_RS09170	COG1570	exodeoxyribonuclease VII activity
GKZ67_RS09175	COG1722	exodeoxyribonuclease VII activity
GKZ67_RS09195	COG1012	belongs to the aldehyde dehydrogenase family
GKZ67_RS09200	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GKZ67_RS09255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKZ67_RS09265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GKZ67_RS09280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKZ67_RS09285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GKZ67_RS09295	COG5499	transcription regulator containing HTH domain
GKZ67_RS09305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GKZ67_RS09315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKZ67_RS09320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GKZ67_RS09325	COG0511	ligase activity, forming carbon-carbon bonds
GKZ67_RS09330	COG0439	Biotin carboxylase
GKZ67_RS09340	COG4636	protein conserved in cyanobacteria
GKZ67_RS09360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GKZ67_RS09375	COG1086	Polysaccharide biosynthesis protein
GKZ67_RS09390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GKZ67_RS09405	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GKZ67_RS09420	COG2089	acid synthase
GKZ67_RS09440	COG4251	negative regulation of phosphorylation
GKZ67_RS09455	COG0531	amino acid
GKZ67_RS09500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GKZ67_RS09510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GKZ67_RS09510	COG0519	Catalyzes the synthesis of GMP from XMP
GKZ67_RS09525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GKZ67_RS09545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GKZ67_RS09555	COG0717	Belongs to the dCTP deaminase family
GKZ67_RS09585	COG0012	GTP binding
GKZ67_RS09635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GKZ67_RS09660	COG1363	Peptidase, m42
GKZ67_RS09670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GKZ67_RS09705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKZ67_RS09725	COG3275	phosphorelay sensor kinase activity
GKZ67_RS09730	COG3279	Response regulator of the LytR AlgR family
GKZ67_RS09745	COG3275	phosphorelay sensor kinase activity
GKZ67_RS09760	COG4206	TonB-dependent receptor
GKZ67_RS09760	COG1629	transport
GKZ67_RS09780	COG1288	antiporter activity
GKZ67_RS09795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKZ67_RS09930	COG0671	phosphoesterase, PA-phosphatase related
GKZ67_RS09965	COG0670	Belongs to the BI1 family
GKZ67_RS09975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GKZ67_RS09985	COG1132	(ABC) transporter
GKZ67_RS10010	COG1764	response to oxidative stress
GKZ67_RS10020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKZ67_RS10045	COG0514	ATP-dependent DNA helicase (RecQ)
GKZ67_RS10050	COG0116	Belongs to the methyltransferase superfamily
GKZ67_RS10050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GKZ67_RS10100	COG4251	negative regulation of phosphorylation
GKZ67_RS10105	COG4251	negative regulation of phosphorylation
GKZ67_RS10115	COG5002	protein histidine kinase activity
GKZ67_RS10130	COG1193	negative regulation of DNA recombination
GKZ67_RS10160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GKZ67_RS10185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GKZ67_RS10185	COG0617	tRNA 3'-terminal CCA addition
GKZ67_RS10185	COG0517	IMP dehydrogenase activity
GKZ67_RS10195	COG0009	L-threonylcarbamoyladenylate synthase
GKZ67_RS10200	COG0346	lactoylglutathione lyase activity
GKZ67_RS10220	COG5002	protein histidine kinase activity
GKZ67_RS10225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GKZ67_RS10245	COG4181	ATPase activity
GKZ67_RS10255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GKZ67_RS10255	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GKZ67_RS10270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GKZ67_RS10305	COG0300	oxidoreductase activity
GKZ67_RS10325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GKZ67_RS10360	COG1501	Belongs to the glycosyl hydrolase 31 family
GKZ67_RS10365	COG1501	Belongs to the glycosyl hydrolase 31 family
GKZ67_RS10405	COG0443	Heat shock 70 kDa protein
GKZ67_RS10415	COG0420	3'-5' exonuclease activity
GKZ67_RS10435	COG0419	ATPase involved in DNA repair
GKZ67_RS10520	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GKZ67_RS10555	COG1538	Outer membrane efflux protein
GKZ67_RS10560	COG2259	Doxx family
GKZ67_RS10565	COG1132	(ABC) transporter
GKZ67_RS10615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GKZ67_RS10650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GKZ67_RS10805	COG2801	Transposase and inactivated derivatives
GKZ67_RS10820	COG2801	Transposase and inactivated derivatives
GKZ67_RS10830	COG3547	Transposase (IS116 IS110 IS902 family)
GKZ67_RS10905	COG1011	Hydrolase
GKZ67_RS10930	COG0126	phosphoglycerate kinase activity
GKZ67_RS10955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKZ67_RS10960	COG0514	ATP-dependent DNA helicase (RecQ)
GKZ67_RS10965	COG0590	tRNA wobble adenosine to inosine editing
GKZ67_RS10975	COG0187	DNA topoisomerase II activity
GKZ67_RS11000	COG2304	oxidoreductase activity
GKZ67_RS11015	COG0183	Belongs to the thiolase family
GKZ67_RS11040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKZ67_RS11040	COG0551	DNA topoisomerase type I activity
GKZ67_RS11045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKZ67_RS11045	COG0551	DNA topoisomerase type I activity
GKZ67_RS11055	COG0697	spore germination
GKZ67_RS11075	COG0288	reversible hydration of carbon dioxide
GKZ67_RS11100	COG0745	RESPONSE REGULATOR receiver
GKZ67_RS11120	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKZ67_RS11125	COG4677	pectinesterase activity
GKZ67_RS11130	COG4677	pectinesterase activity
GKZ67_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS11165	COG0702	epimerase
GKZ67_RS11180	COG2721	sulfolactate sulfo-lyase activity
GKZ67_RS11185	COG1904	glucuronate isomerase
GKZ67_RS11215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GKZ67_RS11220	COG1012	belongs to the aldehyde dehydrogenase family
GKZ67_RS11265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GKZ67_RS11280	COG0488	(ABC) transporter
GKZ67_RS11325	COG0300	oxidoreductase activity
GKZ67_RS11335	COG0412	Dienelactone hydrolase
GKZ67_RS11345	COG4773	Receptor
GKZ67_RS11350	COG0730	response to heat
GKZ67_RS11355	COG0305	Participates in initiation and elongation during chromosome replication
GKZ67_RS11360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKZ67_RS11380	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKZ67_RS11385	COG0739	heme binding
GKZ67_RS11395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GKZ67_RS11405	COG0300	oxidoreductase activity
GKZ67_RS11435	COG0443	Heat shock 70 kDa protein
GKZ67_RS11480	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GKZ67_RS11485	COG0165	Argininosuccinate lyase
GKZ67_RS11495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GKZ67_RS11505	COG0137	argininosuccinate synthase activity
GKZ67_RS11510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GKZ67_RS11535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GKZ67_RS11560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GKZ67_RS11575	COG0832	Belongs to the urease beta subunit family
GKZ67_RS11575	COG0831	urea catabolic process
GKZ67_RS11600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GKZ67_RS11645	COG0829	nickel cation binding
GKZ67_RS11700	COG1234	tRNA 3'-trailer cleavage
GKZ67_RS11715	COG0180	Tryptophanyl-tRNA synthetase
GKZ67_RS11735	COG1082	Xylose isomerase domain protein TIM barrel
GKZ67_RS11755	COG0824	Thioesterase
GKZ67_RS11760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GKZ67_RS11785	COG0542	response to heat
GKZ67_RS11855	COG1515	deoxyribonuclease V activity
GKZ67_RS11865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKZ67_RS11870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKZ67_RS11875	COG0709	Synthesizes selenophosphate from selenide and ATP
GKZ67_RS11885	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GKZ67_RS11890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKZ67_RS11895	COG1007	ATP synthesis coupled electron transport
GKZ67_RS11920	COG1011	Hydrolase
GKZ67_RS11950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GKZ67_RS11980	COG1012	belongs to the aldehyde dehydrogenase family
GKZ67_RS11985	COG0175	sulfate reduction
GKZ67_RS11990	COG0175	sulfate reduction
GKZ67_RS12000	COG1648	precorrin-2 dehydrogenase activity
GKZ67_RS12000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKZ67_RS12010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GKZ67_RS12020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKZ67_RS12035	COG0730	response to heat
GKZ67_RS12075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GKZ67_RS12095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKZ67_RS12115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GKZ67_RS12120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKZ67_RS12145	COG0746	molybdenum cofactor guanylyltransferase activity
GKZ67_RS12145	COG0315	cyclic pyranopterin monophosphate synthase activity
GKZ67_RS12170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GKZ67_RS12175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GKZ67_RS12185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GKZ67_RS12190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GKZ67_RS12195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKZ67_RS12210	COG0594	ribonuclease P activity
GKZ67_RS12215	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GKZ67_RS12250	COG0513	Belongs to the DEAD box helicase family
GKZ67_RS12260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GKZ67_RS12290	COG0606	chelatase, subunit chli
GKZ67_RS12300	COG0167	dihydroorotate dehydrogenase activity
GKZ67_RS12330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKZ67_RS12340	COG0493	'glutamate synthase
GKZ67_RS12355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKZ67_RS12360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GKZ67_RS12365	COG1012	belongs to the aldehyde dehydrogenase family
GKZ67_RS12380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GKZ67_RS12425	COG1045	serine acetyltransferase
GKZ67_RS12440	COG0429	hydrolase of the alpha beta-hydrolase fold
GKZ67_RS12450	COG0268	Binds directly to 16S ribosomal RNA
GKZ67_RS12470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKZ67_RS12475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GKZ67_RS12480	COG0571	ribonuclease III activity
GKZ67_RS12505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GKZ67_RS12545	COG2814	Major facilitator Superfamily
GKZ67_RS12565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKZ67_RS12570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKZ67_RS12575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKZ67_RS12595	COG1034	ATP synthesis coupled electron transport
GKZ67_RS12600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GKZ67_RS12605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKZ67_RS12610	COG0839	Belongs to the complex I subunit 6 family
GKZ67_RS12655	COG2211	Major facilitator Superfamily
GKZ67_RS12665	COG0105	UTP biosynthetic process
GKZ67_RS12670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GKZ67_RS12675	COG0545	Peptidyl-prolyl cis-trans isomerase
GKZ67_RS12685	COG0545	Peptidyl-prolyl cis-trans isomerase
GKZ67_RS12700	COG1435	thymidine kinase activity
GKZ67_RS12740	COG0772	Belongs to the SEDS family
GKZ67_RS12750	COG0768	penicillin binding
GKZ67_RS12755	COG0463	Glycosyl transferase, family 2
GKZ67_RS12840	COG0791	NLP P60 protein
GKZ67_RS12840	COG0741	lytic transglycosylase activity
GKZ67_RS12845	COG0277	FAD linked oxidase domain protein
GKZ67_RS12850	COG0154	amidase activity
GKZ67_RS12965	COG0756	dUTP diphosphatase activity
GKZ67_RS12970	COG1164	Oligoendopeptidase f
GKZ67_RS12975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GKZ67_RS12975	COG1017	nitric oxide dioxygenase activity
GKZ67_RS13005	COG2755	lipolytic protein G-D-S-L family
GKZ67_RS13005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GKZ67_RS13010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GKZ67_RS13100	COG3325	Belongs to the glycosyl hydrolase 18 family
GKZ67_RS13100	COG3469	chitinase activity
GKZ67_RS13110	COG4206	TonB-dependent receptor
GKZ67_RS13110	COG1629	transport
GKZ67_RS13125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GKZ67_RS13135	COG0405	Gamma-glutamyltransferase
GKZ67_RS13140	COG0779	Required for maturation of 30S ribosomal subunits
GKZ67_RS13145	COG0195	Participates in both transcription termination and antitermination
GKZ67_RS13150	COG5180	pathogenesis
GKZ67_RS13150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GKZ67_RS13160	COG1970	mechanosensitive ion channel activity
GKZ67_RS13165	COG1024	Enoyl-CoA hydratase
GKZ67_RS13175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKZ67_RS13180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKZ67_RS13185	COG0154	amidase activity
GKZ67_RS13190	COG1388	LysM domain
GKZ67_RS13190	COG0791	NLP P60 protein
GKZ67_RS13195	COG0280	phosphate acetyltransferase
GKZ67_RS13195	COG0281	malic enzyme
GKZ67_RS13200	COG0632	four-way junction helicase activity
GKZ67_RS13215	COG0509	glycine decarboxylation via glycine cleavage system
GKZ67_RS13235	COG1561	YicC-like family, N-terminal region
GKZ67_RS13260	COG0596	Alpha beta hydrolase
GKZ67_RS13270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GKZ67_RS13285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GKZ67_RS13290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GKZ67_RS13320	COG0357	Ribosomal RNA small subunit methyltransferase G
GKZ67_RS13325	COG0668	transmembrane transport
GKZ67_RS13335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKZ67_RS13365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GKZ67_RS13375	COG0626	cystathionine gamma-synthase activity
GKZ67_RS13380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GKZ67_RS13395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKZ67_RS13405	COG0193	aminoacyl-tRNA hydrolase activity
GKZ67_RS13410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKZ67_RS13410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKZ67_RS13440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKZ67_RS13445	COG4251	negative regulation of phosphorylation
GKZ67_RS13450	COG0784	Response regulator, receiver
GKZ67_RS13465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GKZ67_RS13470	COG0726	polysaccharide deacetylase
GKZ67_RS13475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GKZ67_RS13480	COG0583	DNA-binding transcription factor activity
GKZ67_RS13485	COG2990	Protein conserved in bacteria
GKZ67_RS13525	COG4191	Histidine kinase
GKZ67_RS13545	COG1446	asparaginase
GKZ67_RS13560	COG3685	Protein conserved in bacteria
GKZ67_RS13565	COG3547	Transposase (IS116 IS110 IS902 family)
GKZ67_RS13570	COG2205	protein histidine kinase activity
GKZ67_RS13585	COG0318	PFAM AMP-dependent synthetase and ligase
GKZ67_RS13590	COG1472	Belongs to the glycosyl hydrolase 3 family
GKZ67_RS13610	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GKZ67_RS13625	COG2967	ApaG domain
GKZ67_RS13640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GKZ67_RS13650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GKZ67_RS13660	COG2177	Part of the ABC transporter FtsEX involved in
GKZ67_RS13670	COG1968	undecaprenyl-diphosphatase activity
GKZ67_RS13675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GKZ67_RS13680	COG0196	riboflavin kinase activity
GKZ67_RS13695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GKZ67_RS13715	COG3153	acetyltransferase
GKZ67_RS13715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKZ67_RS13750	COG0714	Associated with various cellular activities
GKZ67_RS13760	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GKZ67_RS13770	COG2169	Transcriptional regulator
GKZ67_RS13770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GKZ67_RS13775	COG3608	succinylglutamate desuccinylase aspartoacylase
GKZ67_RS13775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GKZ67_RS13785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKZ67_RS13835	COG3335	DDE superfamily endonuclease
GKZ67_RS13900	COG5000	phosphorelay sensor kinase activity
GKZ67_RS13935	COG1845	cytochrome c oxidase, subunit III
GKZ67_RS13940	COG1845	cytochrome c oxidase, subunit III
GKZ67_RS13955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GKZ67_RS13960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKZ67_RS13985	COG0437	4 iron, 4 sulfur cluster binding
GKZ67_RS13995	COG0360	Binds together with S18 to 16S ribosomal RNA
GKZ67_RS14000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GKZ67_RS14005	COG0359	binds to the 23S rRNA
GKZ67_RS14020	COG1331	Highly conserved protein containing a thioredoxin domain
GKZ67_RS14025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GKZ67_RS14040	COG0006	proline dipeptidase activity
GKZ67_RS14045	COG0671	phosphoesterase, PA-phosphatase related
GKZ67_RS14085	COG3118	belongs to the thioredoxin family
GKZ67_RS14105	COG1522	sequence-specific DNA binding
GKZ67_RS14115	COG1253	flavin adenine dinucleotide binding
GKZ67_RS14125	COG2314	TM2 domain
GKZ67_RS14165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GKZ67_RS14270	COG0438	transferase activity, transferring glycosyl groups
GKZ67_RS14275	COG0492	ferredoxin-NADP+ reductase activity
GKZ67_RS14285	COG5434	Belongs to the glycosyl hydrolase 28 family
GKZ67_RS14320	COG0730	response to heat
GKZ67_RS14325	COG3258	Cytochrome c
GKZ67_RS14335	COG0138	bifunctional purine biosynthesis protein purh
GKZ67_RS14370	COG1278	Cold shock
GKZ67_RS14380	COG0633	Ferredoxin
GKZ67_RS14405	COG2198	Histidine kinase
GKZ67_RS14405	COG0784	Response regulator, receiver
GKZ67_RS14405	COG5002	protein histidine kinase activity
GKZ67_RS14410	COG3279	Response regulator of the LytR AlgR family
GKZ67_RS14415	COG3279	Response regulator of the LytR AlgR family
GKZ67_RS14430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKZ67_RS14455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GKZ67_RS14455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKZ67_RS14460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKZ67_RS14465	COG1183	phosphatidylcholine synthase activity
GKZ67_RS14495	COG0612	Peptidase, M16
GKZ67_RS14560	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GKZ67_RS14570	COG1490	D-aminoacyl-tRNA deacylase activity
GKZ67_RS14585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GKZ67_RS14590	COG4771	TonB-dependent receptor
GKZ67_RS14600	COG4771	TonB-dependent receptor
GKZ67_RS14605	COG0702	epimerase
GKZ67_RS14640	COG1073	alpha beta
GKZ67_RS14650	COG2885	chlorophyll binding
GKZ67_RS14655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GKZ67_RS14660	COG0300	oxidoreductase activity
GKZ67_RS14700	COG2137	regulation of response to DNA damage stimulus
GKZ67_RS14710	COG4771	TonB-dependent receptor
GKZ67_RS14730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKZ67_RS14755	COG0514	ATP-dependent DNA helicase (RecQ)
GKZ67_RS14795	COG4999	Histidine kinase
GKZ67_RS14795	COG2205	protein histidine kinase activity
GKZ67_RS14795	COG3437	response regulator, receiver
GKZ67_RS14795	COG3850	Histidine kinase
GKZ67_RS14800	COG0784	Response regulator, receiver
GKZ67_RS14800	COG2205	protein histidine kinase activity
GKZ67_RS14805	COG3279	Response regulator of the LytR AlgR family
GKZ67_RS14865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKZ67_RS14890	COG0254	rRNA binding
GKZ67_RS14900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GKZ67_RS14905	COG0572	uridine kinase
GKZ67_RS14925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKZ67_RS15005	COG2255	four-way junction helicase activity
GKZ67_RS15035	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GKZ67_RS15085	COG3361	conserved protein (COG2071)
GKZ67_RS15095	COG0300	oxidoreductase activity
GKZ67_RS15125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GKZ67_RS15135	COG0714	Associated with various cellular activities
GKZ67_RS15165	COG0745	RESPONSE REGULATOR receiver
GKZ67_RS15170	COG5002	protein histidine kinase activity
GKZ67_RS15180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GKZ67_RS15185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GKZ67_RS15190	COG0052	Belongs to the universal ribosomal protein uS2 family
GKZ67_RS15195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GKZ67_RS15255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKZ67_RS15270	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GKZ67_RS15310	COG0203	ribosomal protein L17
GKZ67_RS15315	COG0202	RNA polymerase activity
GKZ67_RS15320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GKZ67_RS15325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GKZ67_RS15330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GKZ67_RS15335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GKZ67_RS15340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GKZ67_RS15355	COG0200	Binds to the 23S rRNA
GKZ67_RS15365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GKZ67_RS15370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GKZ67_RS15375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GKZ67_RS15385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GKZ67_RS15395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GKZ67_RS15400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GKZ67_RS15405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GKZ67_RS15410	COG0255	Belongs to the universal ribosomal protein uL29 family
GKZ67_RS15415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GKZ67_RS15420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GKZ67_RS15430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GKZ67_RS15435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GKZ67_RS15440	COG0089	rRNA binding
GKZ67_RS15445	COG0088	Forms part of the polypeptide exit tunnel
GKZ67_RS15450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GKZ67_RS15460	COG1216	Glycosyl transferase, family 2
GKZ67_RS15465	COG0051	transcription antitermination factor activity, RNA binding
GKZ67_RS15470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GKZ67_RS15475	COG0049	tRNA binding
GKZ67_RS15480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GKZ67_RS15490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GKZ67_RS15500	COG0222	ribosome binding
GKZ67_RS15505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GKZ67_RS15510	COG0081	regulation of translation
GKZ67_RS15515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GKZ67_RS15570	COG0528	UMP kinase activity
GKZ67_RS15575	COG0233	cytoplasmic translational termination
GKZ67_RS15580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GKZ67_RS15585	COG0194	GDP metabolic process
GKZ67_RS15595	COG1595	DNA-templated transcription, initiation
GKZ67_RS15605	COG0463	Glycosyl transferase, family 2
GKZ67_RS15615	COG4221	oxidoreductase activity
GKZ67_RS15635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GKZ67_RS15645	COG4974	Belongs to the 'phage' integrase family
GKZ67_RS15650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GKZ67_RS15655	COG1960	acyl-CoA dehydrogenase activity
GKZ67_RS15685	COG1809	phosphosulfolactate synthase activity
GKZ67_RS15710	COG3781	membrane
GKZ67_RS15715	COG0586	Pfam SNARE associated Golgi protein
GKZ67_RS15720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GKZ67_RS15735	COG0556	nucleotide-excision repair
GKZ67_RS15745	COG1752	Esterase of the alpha-beta hydrolase superfamily
GKZ67_RS15805	COG2135	peptidase activity
GKZ67_RS15815	COG0366	Alpha amylase catalytic
GKZ67_RS15835	COG0242	peptide deformylase activity
GKZ67_RS15840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GKZ67_RS15845	COG0793	Belongs to the peptidase S41A family
GKZ67_RS15845	COG3409	Peptidoglycan-binding domain 1 protein
GKZ67_RS15865	COG0300	oxidoreductase activity
GKZ67_RS15875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GKZ67_RS15885	COG0534	Mate efflux family protein
GKZ67_RS15895	COG1473	amidohydrolase
GKZ67_RS15905	COG1640	4-alpha-glucanotransferase
GKZ67_RS15910	COG1640	4-alpha-glucanotransferase
GKZ67_RS15950	COG0315	cyclic pyranopterin monophosphate synthase activity
GKZ67_RS15955	COG0314	molybdopterin synthase activity
GKZ67_RS15965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GKZ67_RS16020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKZ67_RS16030	COG0811	peptide transport
GKZ67_RS16075	COG0564	pseudouridine synthase activity
GKZ67_RS16090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKZ67_RS16095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GKZ67_RS16110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GKZ67_RS16150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GKZ67_RS16195	COG3604	Transcriptional regulator
GKZ67_RS16210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GKZ67_RS16215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKZ67_RS16275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GKZ67_RS16280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GKZ67_RS16285	COG0805	protein transport
GKZ67_RS16305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKZ67_RS16315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GKZ67_RS16365	COG0456	acetyltransferase
GKZ67_RS16415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GKZ67_RS16435	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS16450	COG3047	cAMP biosynthetic process
GKZ67_RS16450	COG2885	chlorophyll binding
GKZ67_RS16460	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS16530	COG0243	molybdopterin cofactor binding
GKZ67_RS16535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GKZ67_RS16545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GKZ67_RS16565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GKZ67_RS16580	COG0436	Aminotransferase
GKZ67_RS16585	COG5002	protein histidine kinase activity
GKZ67_RS16590	COG2205	protein histidine kinase activity
GKZ67_RS16590	COG0745	RESPONSE REGULATOR receiver
GKZ67_RS16590	COG3292	Two component regulator propeller
GKZ67_RS16595	COG2885	chlorophyll binding
GKZ67_RS16605	COG2181	nitrate reductase activity
GKZ67_RS16605	COG0247	lactate metabolic process
GKZ67_RS16615	COG0247	lactate metabolic process
GKZ67_RS16615	COG2181	nitrate reductase activity
GKZ67_RS16625	COG2885	chlorophyll binding
GKZ67_RS16645	COG3844	kynureninase activity
GKZ67_RS16655	COG0688	phosphatidylethanolamine metabolic process
GKZ67_RS16665	COG0575	Belongs to the CDS family
GKZ67_RS16695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GKZ67_RS16705	COG0363	glucosamine-6-phosphate deaminase activity
GKZ67_RS16710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GKZ67_RS16730	COG1462	curli production assembly transport component CsgG
GKZ67_RS16790	COG0531	amino acid
GKZ67_RS16830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKZ67_RS16835	COG1956	GAF domain-containing protein
GKZ67_RS16840	COG0668	transmembrane transport
GKZ67_RS16850	COG0640	Transcriptional regulator
GKZ67_RS16855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GKZ67_RS16865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GKZ67_RS16870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKZ67_RS16880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GKZ67_RS16935	COG0662	Cupin 2, conserved barrel domain protein
GKZ67_RS16955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKZ67_RS16975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GKZ67_RS16975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GKZ67_RS16985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKZ67_RS17005	COG1139	Iron-sulfur cluster binding protein
GKZ67_RS17020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GKZ67_RS17025	COG1309	transcriptional regulator
GKZ67_RS17045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKZ67_RS17055	COG0791	NLP P60 protein
GKZ67_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS17080	COG0492	ferredoxin-NADP+ reductase activity
GKZ67_RS17095	COG1401	restriction endodeoxyribonuclease activity
GKZ67_RS17115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKZ67_RS17140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GKZ67_RS17155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GKZ67_RS17175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GKZ67_RS17185	COG0151	Belongs to the GarS family
GKZ67_RS17210	COG0284	orotidine-5'-phosphate decarboxylase activity
GKZ67_RS17215	COG0284	orotidine-5'-phosphate decarboxylase activity
GKZ67_RS17290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GKZ67_RS17305	COG0488	(ABC) transporter
GKZ67_RS17325	COG1121	(ABC) transporter
GKZ67_RS17340	COG2885	chlorophyll binding
GKZ67_RS17350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKZ67_RS17355	COG1040	competence protein
GKZ67_RS17370	COG0708	Exodeoxyribonuclease III
GKZ67_RS17390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKZ67_RS17445	COG1472	Belongs to the glycosyl hydrolase 3 family
GKZ67_RS17540	COG3237	CsbD-like
GKZ67_RS17545	COG0123	including yeast histone deacetylase and acetoin utilization protein
GKZ67_RS17565	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GKZ67_RS17565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKZ67_RS17570	COG0251	oxidation-reduction process
GKZ67_RS17580	COG0297	glycogen (starch) synthase activity
GKZ67_RS17585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKZ67_RS17595	COG1704	LemA family
GKZ67_RS17635	COG3547	Transposase (IS116 IS110 IS902 family)
GKZ67_RS17650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GKZ67_RS17675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GKZ67_RS17680	COG1187	pseudouridine synthase activity
GKZ67_RS17690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GKZ67_RS17700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GKZ67_RS17705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKZ67_RS17720	COG0584	glycerophosphoryl diester phosphodiesterase
GKZ67_RS17755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GKZ67_RS17760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GKZ67_RS17780	COG0423	glycine-tRNA ligase activity
GKZ67_RS17785	COG0306	phosphate transporter
GKZ67_RS17830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GKZ67_RS17885	COG2201	protein-glutamate methylesterase activity
GKZ67_RS17905	COG1085	galactose-1-phosphate uridylyltransferase
GKZ67_RS17915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GKZ67_RS17930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GKZ67_RS17935	COG0601	transmembrane transport
GKZ67_RS17995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKZ67_RS18010	COG2211	Major facilitator Superfamily
GKZ67_RS18030	COG1295	ribonuclease BN
GKZ67_RS18045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GKZ67_RS18080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GKZ67_RS18095	COG4946	Tricorn protease homolog
GKZ67_RS18095	COG0793	Belongs to the peptidase S41A family
GKZ67_RS18100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKZ67_RS18110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GKZ67_RS18125	COG0612	Peptidase, M16
GKZ67_RS18140	COG4771	TonB-dependent receptor
GKZ67_RS18185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GKZ67_RS18190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GKZ67_RS18200	COG1611	Belongs to the LOG family
GKZ67_RS18210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKZ67_RS18210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKZ67_RS18245	COG0492	ferredoxin-NADP+ reductase activity
GKZ67_RS18250	COG0484	heat shock protein binding
GKZ67_RS18275	COG1960	acyl-CoA dehydrogenase activity
GKZ67_RS18280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GKZ67_RS18280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GKZ67_RS18295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GKZ67_RS18335	COG2814	Major facilitator Superfamily
GKZ67_RS18425	COG2267	carboxylic ester hydrolase activity
GKZ67_RS18485	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKZ67_RS18490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKZ67_RS18535	COG1278	Cold shock
GKZ67_RS18540	COG1187	pseudouridine synthase activity
GKZ67_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS18575	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GKZ67_RS18585	COG0693	protein deglycase activity
GKZ67_RS18630	COG4124	Belongs to the glycosyl hydrolase 26 family
GKZ67_RS18655	COG1137	ATPase activity
GKZ67_RS18675	COG2304	oxidoreductase activity
GKZ67_RS18695	COG0456	acetyltransferase
GKZ67_RS18705	COG0113	porphobilinogen synthase activity
GKZ67_RS18715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKZ67_RS18715	COG2022	thiamine diphosphate biosynthetic process
GKZ67_RS18720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKZ67_RS18725	COG0251	oxidation-reduction process
GKZ67_RS18735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GKZ67_RS18740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GKZ67_RS18750	COG0552	protein localization to endoplasmic reticulum
GKZ67_RS18820	COG3548	integral membrane protein
GKZ67_RS18835	COG1733	regulation of RNA biosynthetic process
GKZ67_RS18870	COG4251	negative regulation of phosphorylation
GKZ67_RS18895	COG3959	Transketolase, thiamine diphosphate binding domain
GKZ67_RS18900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GKZ67_RS18905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GKZ67_RS18910	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS18915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GKZ67_RS18920	COG2089	acid synthase
GKZ67_RS18945	COG2353	YceI-like domain
GKZ67_RS18960	COG1252	NADH dehydrogenase
GKZ67_RS18970	COG0668	transmembrane transport
GKZ67_RS19000	COG0667	Aldo Keto reductase
GKZ67_RS19005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GKZ67_RS19030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GKZ67_RS19055	COG1666	GTP binding
GKZ67_RS19060	COG1253	flavin adenine dinucleotide binding
GKZ67_RS19075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKZ67_RS19080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GKZ67_RS19085	COG4206	TonB-dependent receptor
GKZ67_RS19090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKZ67_RS19100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKZ67_RS19105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GKZ67_RS19110	COG2197	response regulator
GKZ67_RS19140	COG4242	Belongs to the peptidase S51 family
GKZ67_RS19155	COG0792	nuclease activity
GKZ67_RS19160	COG0321	lipoyl(octanoyl) transferase activity
GKZ67_RS19170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKZ67_RS19190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKZ67_RS19210	COG0322	excinuclease ABC activity
GKZ67_RS19235	COG0356	it plays a direct role in the translocation of protons across the membrane
GKZ67_RS19240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKZ67_RS19245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GKZ67_RS19250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKZ67_RS19260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GKZ67_RS19320	COG0101	tRNA pseudouridine synthase activity
GKZ67_RS19325	COG1132	(ABC) transporter
GKZ67_RS19365	COG1132	(ABC) transporter
GKZ67_RS19375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKZ67_RS19385	COG0473	3-isopropylmalate dehydrogenase activity
GKZ67_RS19405	COG0237	dephospho-CoA kinase activity
GKZ67_RS19480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GKZ67_RS19510	COG2890	protein-(glutamine-N5) methyltransferase activity
GKZ67_RS19515	COG2890	protein-(glutamine-N5) methyltransferase activity
GKZ67_RS19565	COG0442	prolyl-tRNA aminoacylation
GKZ67_RS19630	COG0714	Associated with various cellular activities
GKZ67_RS19680	COG4946	Tricorn protease homolog
GKZ67_RS19680	COG0793	Belongs to the peptidase S41A family
GKZ67_RS19725	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GKZ67_RS19745	COG1505	serine-type exopeptidase activity
GKZ67_RS19750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GKZ67_RS19765	COG1609	Transcriptional regulator
GKZ67_RS19775	COG3250	beta-galactosidase activity
GKZ67_RS19780	COG4771	TonB-dependent receptor
GKZ67_RS19790	COG3250	beta-galactosidase activity
GKZ67_RS19795	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS19800	COG1312	Catalyzes the dehydration of D-mannonate
GKZ67_RS19805	COG3507	Belongs to the glycosyl hydrolase 43 family
GKZ67_RS19820	COG1619	proteins homologs of microcin C7 resistance protein MccF
GKZ67_RS19840	COG1652	LysM domain
GKZ67_RS19900	COG0667	Aldo Keto reductase
GKZ67_RS19925	COG2010	Cytochrome c
GKZ67_RS19940	COG2267	carboxylic ester hydrolase activity
GKZ67_RS20010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GKZ67_RS20070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GKZ67_RS20075	COG1914	H( )-stimulated, divalent metal cation uptake system
GKZ67_RS20100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKZ67_RS20155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKZ67_RS20180	COG0538	isocitrate dehydrogenase activity
GKZ67_RS20210	COG1129	ABC transporter
GKZ67_RS20220	COG3842	ATPase activity
GKZ67_RS20240	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GKZ67_RS20245	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GKZ67_RS20250	COG0583	DNA-binding transcription factor activity
GKZ67_RS20275	COG0083	homoserine kinase activity
GKZ67_RS20285	COG0527	aspartate kinase activity
GKZ67_RS20285	COG0460	homoserine dehydrogenase
GKZ67_RS20290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GKZ67_RS20360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GKZ67_RS20370	COG3757	hydrolase, family 25
GKZ67_RS20375	COG4628	conserved protein (DUF2132)
GKZ67_RS20415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GKZ67_RS20420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GKZ67_RS20435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GKZ67_RS20435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKZ67_RS20505	COG2169	Transcriptional regulator
GKZ67_RS20505	COG1917	Cupin 2, conserved barrel domain protein
GKZ67_RS20510	COG1028	Short-chain dehydrogenase reductase Sdr
GKZ67_RS20590	COG3104	oligopeptide transport
GKZ67_RS20600	COG3386	PFAM SMP-30 Gluconolaconase
GKZ67_RS20610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKZ67_RS20630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GKZ67_RS20630	COG0189	ligase activity
GKZ67_RS20665	COG4644	lycopene metabolic process
GKZ67_RS20680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GKZ67_RS20730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKZ67_RS20730	COG1754	DNA topoisomerase type I activity
GKZ67_RS20735	COG1754	DNA topoisomerase type I activity
GKZ67_RS20735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKZ67_RS21190	COG1074	ATP-dependent DNA helicase activity
GKZ67_RS21200	COG4227	nucleotidyltransferase activity
GKZ67_RS21255	COG2801	Transposase and inactivated derivatives
GKZ67_RS21450	COG2801	Transposase and inactivated derivatives
GKZ67_RS21580	COG1192	Involved in chromosome partitioning
GKZ67_RS21650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GKZ67_RS21745	COG2801	Transposase and inactivated derivatives
GKZ67_RS21790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKZ67_RS21795	COG0596	Alpha beta hydrolase
GKZ67_RS21795	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKZ67_RS21865	COG4206	TonB-dependent receptor
GKZ67_RS21925	COG3547	Transposase (IS116 IS110 IS902 family)
GKZ67_RS22040	COG1203	CRISPR-associated helicase, Cas3
GKZ67_RS22055	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GKZ67_RS22065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GKZ67_RS22075	COG3012	SEC-C Motif Domain Protein
GKZ67_RS22080	COG4644	lycopene metabolic process
GKZ67_RS22250	COG2801	Transposase and inactivated derivatives
GKZ67_RS22290	COG3547	Transposase (IS116 IS110 IS902 family)