locus-tag	class	description
GUY19_RS00025	COG0012	GTP binding
GUY19_RS00050	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GUY19_RS00065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GUY19_RS00095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GUY19_RS00125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GUY19_RS00140	COG2363	Small membrane protein
GUY19_RS00145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GUY19_RS00170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GUY19_RS00180	COG0534	Mate efflux family protein
GUY19_RS00185	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GUY19_RS00190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GUY19_RS00230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GUY19_RS00300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GUY19_RS00325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GUY19_RS00390	COG4977	sequence-specific DNA binding
GUY19_RS00405	COG2972	Histidine kinase
GUY19_RS00410	COG3279	Response regulator of the LytR AlgR family
GUY19_RS00415	COG0488	(ABC) transporter
GUY19_RS00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GUY19_RS00445	COG1462	curli production assembly transport component CsgG
GUY19_RS00525	COG0822	iron-sulfur transferase activity
GUY19_RS00550	COG0617	tRNA 3'-terminal CCA addition
GUY19_RS00585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GUY19_RS00595	COG3876	Protein conserved in bacteria
GUY19_RS00610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GUY19_RS00615	COG1164	Oligoendopeptidase f
GUY19_RS00630	COG2151	metal-sulfur cluster biosynthetic enzyme
GUY19_RS00645	COG3396	Phenylacetate-CoA oxygenase
GUY19_RS00650	COG1309	transcriptional regulator
GUY19_RS00660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GUY19_RS00675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GUY19_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS00715	COG0537	adenosine 5'-monophosphoramidase activity
GUY19_RS00890	COG4206	TonB-dependent receptor
GUY19_RS00890	COG1629	transport
GUY19_RS01010	COG5002	protein histidine kinase activity
GUY19_RS01020	COG4191	Histidine kinase
GUY19_RS01020	COG2205	protein histidine kinase activity
GUY19_RS01020	COG0745	RESPONSE REGULATOR receiver
GUY19_RS01030	COG4251	negative regulation of phosphorylation
GUY19_RS01040	COG0308	aminopeptidase N
GUY19_RS01045	COG1131	(ABC) transporter
GUY19_RS01055	COG3275	phosphorelay sensor kinase activity
GUY19_RS01060	COG3279	Response regulator of the LytR AlgR family
GUY19_RS01065	COG3973	AAA domain
GUY19_RS01075	COG0538	isocitrate dehydrogenase activity
GUY19_RS01095	COG1131	(ABC) transporter
GUY19_RS01125	COG2217	Heavy metal translocating P-type atpase
GUY19_RS01140	COG3278	Belongs to the heme-copper respiratory oxidase family
GUY19_RS01150	COG2010	Cytochrome c
GUY19_RS01155	COG0348	domain, Protein
GUY19_RS01175	COG0408	coproporphyrinogen oxidase activity
GUY19_RS01180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GUY19_RS01195	COG1312	Catalyzes the dehydration of D-mannonate
GUY19_RS01200	COG2115	Belongs to the xylose isomerase family
GUY19_RS01210	COG2217	Heavy metal translocating P-type atpase
GUY19_RS01260	COG2502	aspartate--ammonia ligase
GUY19_RS01315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GUY19_RS01325	COG1953	Uracil, thiamine, allantoin
GUY19_RS01330	COG0339	signal peptide processing
GUY19_RS01335	COG0515	serine threonine protein kinase
GUY19_RS01380	COG0596	Alpha beta hydrolase
GUY19_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS01405	COG1231	oxidoreductase activity
GUY19_RS01410	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS01450	COG0123	including yeast histone deacetylase and acetoin utilization protein
GUY19_RS01470	COG1690	Belongs to the RtcB family
GUY19_RS01475	COG1690	Belongs to the RtcB family
GUY19_RS01540	COG0783	Belongs to the Dps family
GUY19_RS01570	COG0321	lipoyl(octanoyl) transferase activity
GUY19_RS01570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GUY19_RS01575	COG0784	Response regulator, receiver
GUY19_RS01575	COG2205	protein histidine kinase activity
GUY19_RS01580	COG5002	protein histidine kinase activity
GUY19_RS01580	COG2198	Histidine kinase
GUY19_RS01580	COG0784	Response regulator, receiver
GUY19_RS01590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GUY19_RS01595	COG0205	6-phosphofructokinase activity
GUY19_RS01620	COG1595	DNA-templated transcription, initiation
GUY19_RS01625	COG1846	Transcriptional regulator
GUY19_RS01645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GUY19_RS01650	COG2304	oxidoreductase activity
GUY19_RS01655	COG3959	Transketolase, thiamine diphosphate binding domain
GUY19_RS01660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GUY19_RS01670	COG0739	heme binding
GUY19_RS01675	COG0179	Fumarylacetoacetate (FAA) hydrolase
GUY19_RS01695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GUY19_RS01700	COG0305	Participates in initiation and elongation during chromosome replication
GUY19_RS01710	COG4771	TonB-dependent receptor
GUY19_RS01725	COG3384	dioxygenase
GUY19_RS01735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GUY19_RS01755	COG2351	hydroxyisourate hydrolase activity
GUY19_RS01785	COG1125	glycine betaine transport
GUY19_RS01785	COG0517	IMP dehydrogenase activity
GUY19_RS01790	COG1174	glycine betaine transport
GUY19_RS01795	COG3279	Response regulator of the LytR AlgR family
GUY19_RS01800	COG3275	phosphorelay sensor kinase activity
GUY19_RS01815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GUY19_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS01835	COG3186	Phenylalanine-4-hydroxylase
GUY19_RS01840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GUY19_RS01865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GUY19_RS01880	COG1132	(ABC) transporter
GUY19_RS01895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GUY19_RS01900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GUY19_RS01905	COG2080	2 iron, 2 sulfur cluster binding
GUY19_RS01910	COG0303	'Molybdopterin
GUY19_RS01920	COG0746	molybdenum cofactor guanylyltransferase activity
GUY19_RS01925	COG0314	molybdopterin synthase activity
GUY19_RS01935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GUY19_RS01955	COG2080	2 iron, 2 sulfur cluster binding
GUY19_RS01960	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GUY19_RS01965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GUY19_RS01990	COG2226	methyltransferase
GUY19_RS01995	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GUY19_RS02005	COG1597	lipid kinase activity
GUY19_RS02020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GUY19_RS02025	COG1388	LysM domain
GUY19_RS02025	COG1705	Flagellar rod assembly protein muramidase FlgJ
GUY19_RS02040	COG1193	negative regulation of DNA recombination
GUY19_RS02065	COG0116	Belongs to the methyltransferase superfamily
GUY19_RS02075	COG0514	ATP-dependent DNA helicase (RecQ)
GUY19_RS02100	COG1741	Belongs to the pirin family
GUY19_RS02120	COG3228	Belongs to the MtfA family
GUY19_RS02135	COG0513	Belongs to the DEAD box helicase family
GUY19_RS02160	COG1999	signal sequence binding
GUY19_RS02170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GUY19_RS02170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GUY19_RS02180	COG0667	Aldo Keto reductase
GUY19_RS02195	COG2081	HI0933 family
GUY19_RS02205	COG0038	chloride channel
GUY19_RS02210	COG1511	domain protein
GUY19_RS02210	COG3264	Mechanosensitive ion channel
GUY19_RS02260	COG1074	ATP-dependent DNA helicase activity
GUY19_RS02280	COG1278	Cold shock
GUY19_RS02285	COG0513	Belongs to the DEAD box helicase family
GUY19_RS02300	COG2081	HI0933 family
GUY19_RS02305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUY19_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS02335	COG0402	S-adenosylhomocysteine deaminase activity
GUY19_RS02340	COG4717	serine-type aminopeptidase activity
GUY19_RS02350	COG3339	Conserved Protein
GUY19_RS02390	COG0308	aminopeptidase N
GUY19_RS02415	COG0513	Belongs to the DEAD box helicase family
GUY19_RS02445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GUY19_RS02450	COG3541	Predicted nucleotidyltransferase
GUY19_RS02475	COG0740	serine-type endopeptidase activity
GUY19_RS02505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUY19_RS02510	COG1752	Esterase of the alpha-beta hydrolase superfamily
GUY19_RS02545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GUY19_RS02560	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS02580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GUY19_RS02585	COG3104	oligopeptide transport
GUY19_RS02590	COG3104	oligopeptide transport
GUY19_RS02595	COG0459	protein refolding
GUY19_RS02600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GUY19_RS02620	COG3604	Transcriptional regulator
GUY19_RS02625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GUY19_RS02630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GUY19_RS02645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GUY19_RS02655	COG1663	tetraacyldisaccharide 4'-kinase activity
GUY19_RS02670	COG3250	beta-galactosidase activity
GUY19_RS02685	COG1136	(ABC) transporter
GUY19_RS02685	COG0577	efflux transmembrane transporter activity
GUY19_RS02695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GUY19_RS02720	COG3321	synthase
GUY19_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS02720	COG0604	alcohol dehydrogenase
GUY19_RS02735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GUY19_RS02755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GUY19_RS02775	COG2315	Protein conserved in bacteria
GUY19_RS02780	COG1959	2 iron, 2 sulfur cluster binding
GUY19_RS02785	COG2910	NAD(P)H-binding
GUY19_RS02790	COG0495	leucyl-tRNA aminoacylation
GUY19_RS02830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GUY19_RS02840	COG4191	Histidine kinase
GUY19_RS02890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GUY19_RS02910	COG0758	DNA mediated transformation
GUY19_RS02910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GUY19_RS02925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GUY19_RS02945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GUY19_RS02950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GUY19_RS02955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GUY19_RS02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GUY19_RS02975	COG1607	acyl-coa hydrolase
GUY19_RS02985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GUY19_RS02990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GUY19_RS02995	COG0307	riboflavin synthase, alpha
GUY19_RS03015	COG0408	coproporphyrinogen oxidase activity
GUY19_RS03020	COG0022	dehydrogenase e1 component
GUY19_RS03065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GUY19_RS03075	COG3483	tryptophan 2,3-dioxygenase activity
GUY19_RS03080	COG1760	l-serine dehydratase
GUY19_RS03095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GUY19_RS03120	COG2223	nitrite transmembrane transporter activity
GUY19_RS03125	COG0753	catalase activity
GUY19_RS03135	COG0424	maF-like protein
GUY19_RS03145	COG0259	pyridoxamine-phosphate oxidase activity
GUY19_RS03150	COG1678	Uncharacterized ACR, COG1678
GUY19_RS03185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GUY19_RS03195	COG2204	response regulator
GUY19_RS03205	COG5002	protein histidine kinase activity
GUY19_RS03210	COG5002	protein histidine kinase activity
GUY19_RS03235	COG1418	mRNA catabolic process
GUY19_RS03245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GUY19_RS03390	COG0107	imidazoleglycerol-phosphate synthase activity
GUY19_RS03395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GUY19_RS03400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GUY19_RS03405	COG0131	Imidazoleglycerol-phosphate dehydratase
GUY19_RS03405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GUY19_RS03410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GUY19_RS03415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GUY19_RS03420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GUY19_RS03435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GUY19_RS03445	COG1404	Belongs to the peptidase S8 family
GUY19_RS03455	COG0482	sulfurtransferase activity
GUY19_RS03470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GUY19_RS03485	COG0848	biopolymer transport protein
GUY19_RS03490	COG0811	peptide transport
GUY19_RS03530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GUY19_RS03540	COG0156	8-amino-7-oxononanoate synthase activity
GUY19_RS03545	COG0439	Biotin carboxylase
GUY19_RS03560	COG0741	lytic transglycosylase activity
GUY19_RS03560	COG0739	heme binding
GUY19_RS03560	COG1196	nuclear chromosome segregation
GUY19_RS03565	COG0492	ferredoxin-NADP+ reductase activity
GUY19_RS03570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GUY19_RS03575	COG1185	polyribonucleotide nucleotidyltransferase activity
GUY19_RS03580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GUY19_RS03605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GUY19_RS03610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GUY19_RS03615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GUY19_RS03620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GUY19_RS03630	COG2989	Protein conserved in bacteria
GUY19_RS03650	COG3548	integral membrane protein
GUY19_RS03660	COG0628	permease
GUY19_RS03670	COG1199	ATP-dependent helicase activity
GUY19_RS03670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GUY19_RS03695	COG0501	Belongs to the peptidase M48B family
GUY19_RS03730	COG1597	lipid kinase activity
GUY19_RS03765	COG0488	(ABC) transporter
GUY19_RS03780	COG1250	3-hydroxyacyl-CoA dehydrogenase
GUY19_RS03790	COG1446	asparaginase
GUY19_RS03800	COG2171	N-acyltransferase activity
GUY19_RS03805	COG0438	transferase activity, transferring glycosyl groups
GUY19_RS03810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GUY19_RS03820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GUY19_RS03845	COG0602	queuosine metabolic process
GUY19_RS03850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GUY19_RS03865	COG0481	GTPase activity
GUY19_RS03905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUY19_RS03905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUY19_RS03905	COG1703	isobutyryl-CoA mutase activity
GUY19_RS03935	COG0667	Aldo Keto reductase
GUY19_RS03960	COG3158	transport of potassium into the cell
GUY19_RS04000	COG1845	cytochrome c oxidase, subunit III
GUY19_RS04025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GUY19_RS04035	COG0726	polysaccharide deacetylase
GUY19_RS04040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GUY19_RS04045	COG0247	lactate metabolic process
GUY19_RS04115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GUY19_RS04155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GUY19_RS04155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GUY19_RS04160	COG0438	transferase activity, transferring glycosyl groups
GUY19_RS04170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GUY19_RS04180	COG0358	DNA primase activity
GUY19_RS04185	COG0489	protein tyrosine kinase activity
GUY19_RS04190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GUY19_RS04210	COG1063	alcohol dehydrogenase
GUY19_RS04220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GUY19_RS04230	COG2234	aminopeptidase activity
GUY19_RS04240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GUY19_RS04255	COG0456	acetyltransferase
GUY19_RS04260	COG0686	Belongs to the AlaDH PNT family
GUY19_RS04265	COG0802	atpase or kinase
GUY19_RS04275	COG4628	conserved protein (DUF2132)
GUY19_RS04310	COG2204	response regulator
GUY19_RS04315	COG1078	dGTPase activity
GUY19_RS04320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GUY19_RS04325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GUY19_RS04325	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GUY19_RS04330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GUY19_RS04335	COG4133	protoheme IX ABC transporter activity
GUY19_RS04355	COG1058	Belongs to the CinA family
GUY19_RS04355	COG1546	Belongs to the CinA family
GUY19_RS04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUY19_RS04370	COG0525	valine-tRNA ligase activity
GUY19_RS04385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUY19_RS04405	COG0813	purine-nucleoside phosphorylase activity
GUY19_RS04435	COG1674	ftsk spoiiie
GUY19_RS04455	COG4974	Belongs to the 'phage' integrase family
GUY19_RS04465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GUY19_RS04470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GUY19_RS04475	COG2095	MarC family integral membrane protein
GUY19_RS04485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GUY19_RS04490	COG1131	(ABC) transporter
GUY19_RS04515	COG4221	oxidoreductase activity
GUY19_RS04525	COG2226	methyltransferase
GUY19_RS04530	COG2885	chlorophyll binding
GUY19_RS04535	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GUY19_RS04540	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GUY19_RS04555	COG0527	aspartate kinase activity
GUY19_RS04570	COG0450	alkyl hydroperoxide reductase
GUY19_RS04575	COG1519	Transferase
GUY19_RS04580	COG1162	GTPase activity
GUY19_RS04585	COG2084	Dehydrogenase
GUY19_RS04590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GUY19_RS04595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GUY19_RS04600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GUY19_RS04660	COG1215	transferase activity, transferring glycosyl groups
GUY19_RS04675	COG0598	Magnesium transport protein CorA
GUY19_RS04700	COG0531	amino acid
GUY19_RS04720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GUY19_RS04745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GUY19_RS04800	COG1012	belongs to the aldehyde dehydrogenase family
GUY19_RS04805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GUY19_RS04830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GUY19_RS04840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GUY19_RS04845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GUY19_RS04850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GUY19_RS04855	COG5499	transcription regulator containing HTH domain
GUY19_RS04865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GUY19_RS04870	COG0416	fatty acid biosynthetic process
GUY19_RS04875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GUY19_RS04880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GUY19_RS04885	COG0511	ligase activity, forming carbon-carbon bonds
GUY19_RS04890	COG0439	Biotin carboxylase
GUY19_RS04925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GUY19_RS04935	COG1950	PFAM Membrane protein of
GUY19_RS04940	COG0010	Belongs to the arginase family
GUY19_RS04945	COG1776	CheC inhibitor of MCP methylation
GUY19_RS04950	COG0643	Histidine kinase
GUY19_RS04950	COG2198	Histidine kinase
GUY19_RS04955	COG2201	protein-glutamate methylesterase activity
GUY19_RS04960	COG2201	protein-glutamate methylesterase activity
GUY19_RS04965	COG0835	chemotaxis
GUY19_RS04975	COG1754	DNA topoisomerase type I activity
GUY19_RS04975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GUY19_RS04990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GUY19_RS05005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GUY19_RS05015	COG0187	DNA topoisomerase II activity
GUY19_RS05055	COG0183	Belongs to the thiolase family
GUY19_RS05095	COG0124	histidyl-tRNA synthetase
GUY19_RS05100	COG2986	histidine ammonia-lyase
GUY19_RS05110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GUY19_RS05140	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUY19_RS05140	COG0022	dehydrogenase e1 component
GUY19_RS05190	COG1629	transport
GUY19_RS05190	COG4206	TonB-dependent receptor
GUY19_RS05200	COG1063	alcohol dehydrogenase
GUY19_RS05215	COG3250	beta-galactosidase activity
GUY19_RS05255	COG0738	Major facilitator superfamily
GUY19_RS05285	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GUY19_RS05300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GUY19_RS05335	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GUY19_RS05350	COG3250	beta-galactosidase activity
GUY19_RS05390	COG1629	transport
GUY19_RS05390	COG4206	TonB-dependent receptor
GUY19_RS05400	COG0662	Cupin 2, conserved barrel domain protein
GUY19_RS05400	COG2207	Transcriptional regulator
GUY19_RS05405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GUY19_RS05410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GUY19_RS05415	COG3250	beta-galactosidase activity
GUY19_RS05460	COG0590	tRNA wobble adenosine to inosine editing
GUY19_RS05465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GUY19_RS05475	COG1086	Polysaccharide biosynthesis protein
GUY19_RS05480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GUY19_RS05480	COG2755	lipolytic protein G-D-S-L family
GUY19_RS05485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GUY19_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS05500	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GUY19_RS05515	COG2089	acid synthase
GUY19_RS05540	COG0531	amino acid
GUY19_RS05590	COG2884	Cell division ATP-binding protein ftsE
GUY19_RS05600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GUY19_RS05615	COG0519	Catalyzes the synthesis of GMP from XMP
GUY19_RS05615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GUY19_RS05630	COG1132	(ABC) transporter
GUY19_RS05650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GUY19_RS05655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GUY19_RS05725	COG4555	ABC transporter
GUY19_RS05735	COG4221	oxidoreductase activity
GUY19_RS05750	COG0300	oxidoreductase activity
GUY19_RS05755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GUY19_RS05765	COG2318	DinB family
GUY19_RS05775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GUY19_RS05780	COG2086	electron transfer activity
GUY19_RS05810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GUY19_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS05830	COG0415	Belongs to the DNA photolyase family
GUY19_RS05870	COG3186	Phenylalanine-4-hydroxylase
GUY19_RS05880	COG0159	tryptophan synthase activity
GUY19_RS05885	COG0133	tryptophan synthase activity
GUY19_RS05890	COG0135	phosphoribosylanthranilate isomerase activity
GUY19_RS05895	COG0134	indole-3-glycerol-phosphate synthase activity
GUY19_RS05900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GUY19_RS05915	COG2819	hydrolase of the alpha beta superfamily
GUY19_RS05920	COG1629	transport
GUY19_RS05920	COG4206	TonB-dependent receptor
GUY19_RS05925	COG0561	phosphatase activity
GUY19_RS05975	COG2204	response regulator
GUY19_RS05995	COG0022	dehydrogenase e1 component
GUY19_RS06040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GUY19_RS06050	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GUY19_RS06075	COG0038	chloride channel
GUY19_RS06095	COG0252	asparaginase activity
GUY19_RS06100	COG0084	hydrolase, TatD family'
GUY19_RS06105	COG1215	transferase activity, transferring glycosyl groups
GUY19_RS06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GUY19_RS06165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GUY19_RS06175	COG2226	methyltransferase
GUY19_RS06205	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GUY19_RS06210	COG1228	amidohydrolase
GUY19_RS06230	COG1335	isochorismatase
GUY19_RS06240	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GUY19_RS06255	COG0579	oxidoreductase
GUY19_RS06290	COG2072	flavoprotein involved in K transport
GUY19_RS06300	COG1278	Cold shock
GUY19_RS06360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GUY19_RS06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUY19_RS06375	COG0010	Belongs to the arginase family
GUY19_RS06390	COG0217	transcriptional regulatory protein
GUY19_RS06395	COG2267	carboxylic ester hydrolase activity
GUY19_RS06420	COG4682	membrane
GUY19_RS06425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GUY19_RS06430	COG0156	8-amino-7-oxononanoate synthase activity
GUY19_RS06435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GUY19_RS06450	COG2234	aminopeptidase activity
GUY19_RS06460	COG0330	HflC and HflK could
GUY19_RS06475	COG1082	Xylose isomerase domain protein TIM barrel
GUY19_RS06490	COG0277	FAD linked oxidase domain protein
GUY19_RS06500	COG0527	aspartate kinase activity
GUY19_RS06505	COG0019	diaminopimelate decarboxylase activity
GUY19_RS06515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GUY19_RS06520	COG0702	epimerase
GUY19_RS06555	COG0596	Alpha beta hydrolase
GUY19_RS06570	COG0288	reversible hydration of carbon dioxide
GUY19_RS06580	COG0642	Histidine kinase
GUY19_RS06580	COG3850	Histidine kinase
GUY19_RS06590	COG0745	RESPONSE REGULATOR receiver
GUY19_RS06600	COG0489	protein tyrosine kinase activity
GUY19_RS06605	COG2244	polysaccharide biosynthetic process
GUY19_RS06630	COG0463	Glycosyl transferase, family 2
GUY19_RS06660	COG0460	homoserine dehydrogenase
GUY19_RS06675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GUY19_RS06690	COG4310	Domain of unknown function (DUF2172)
GUY19_RS06700	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GUY19_RS06710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GUY19_RS06725	COG0167	dihydroorotate dehydrogenase activity
GUY19_RS06730	COG0493	'glutamate synthase
GUY19_RS06740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GUY19_RS06750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GUY19_RS06770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GUY19_RS06775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GUY19_RS06780	COG1609	Transcriptional regulator
GUY19_RS06785	COG0191	fructose-bisphosphate aldolase activity
GUY19_RS06790	COG0205	6-phosphofructokinase activity
GUY19_RS06805	COG0166	Belongs to the GPI family
GUY19_RS06860	COG1136	(ABC) transporter
GUY19_RS06865	COG0577	efflux transmembrane transporter activity
GUY19_RS06870	COG0280	phosphate acetyltransferase
GUY19_RS06870	COG0281	malic enzyme
GUY19_RS06875	COG0540	Belongs to the ATCase OTCase family
GUY19_RS06880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GUY19_RS06885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GUY19_RS06890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GUY19_RS06915	COG1011	Hydrolase
GUY19_RS06930	COG0126	phosphoglycerate kinase activity
GUY19_RS06935	COG1181	Belongs to the D-alanine--D-alanine ligase family
GUY19_RS06955	COG0514	ATP-dependent DNA helicase (RecQ)
GUY19_RS06965	COG1136	(ABC) transporter
GUY19_RS06975	COG0045	succinate-CoA ligase (ADP-forming) activity
GUY19_RS06985	COG1764	response to oxidative stress
GUY19_RS07000	COG1012	belongs to the aldehyde dehydrogenase family
GUY19_RS07005	COG0673	inositol 2-dehydrogenase activity
GUY19_RS07010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GUY19_RS07020	COG2271	Major facilitator Superfamily
GUY19_RS07025	COG0800	Aldolase
GUY19_RS07035	COG1904	glucuronate isomerase
GUY19_RS07040	COG2721	sulfolactate sulfo-lyase activity
GUY19_RS07045	COG0246	Mannitol dehydrogenase
GUY19_RS07060	COG1917	Cupin 2, conserved barrel domain protein
GUY19_RS07070	COG4206	TonB-dependent receptor
GUY19_RS07070	COG1629	transport
GUY19_RS07075	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GUY19_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS07085	COG1609	Transcriptional regulator
GUY19_RS07095	COG3866	Pectate lyase
GUY19_RS07105	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GUY19_RS07115	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GUY19_RS07125	COG2356	endonuclease I
GUY19_RS07140	COG2388	GCN5-related N-acetyl-transferase
GUY19_RS07175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GUY19_RS07180	COG0671	phosphoesterase, PA-phosphatase related
GUY19_RS07185	COG0673	inositol 2-dehydrogenase activity
GUY19_RS07195	COG1301	dicarboxylic acid transport
GUY19_RS07220	COG2267	carboxylic ester hydrolase activity
GUY19_RS07225	COG3275	phosphorelay sensor kinase activity
GUY19_RS07265	COG1988	membrane-bound metal-dependent
GUY19_RS07315	COG2124	cytochrome p450
GUY19_RS07345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GUY19_RS07360	COG4249	Peptidase C14 caspase catalytic subunit p20
GUY19_RS07360	COG2319	Wd-40 repeat
GUY19_RS07370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GUY19_RS07385	COG1053	succinate dehydrogenase
GUY19_RS07410	COG1858	cytochrome C peroxidase
GUY19_RS07420	COG1858	cytochrome C peroxidase
GUY19_RS07445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GUY19_RS07450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GUY19_RS07455	COG0772	Belongs to the SEDS family
GUY19_RS07460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GUY19_RS07465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GUY19_RS07470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GUY19_RS07475	COG0768	penicillin binding
GUY19_RS07485	COG0275	rRNA processing
GUY19_RS07490	COG2001	Belongs to the MraZ family
GUY19_RS07515	COG3279	Response regulator of the LytR AlgR family
GUY19_RS07520	COG2202	Pas domain
GUY19_RS07520	COG2205	protein histidine kinase activity
GUY19_RS07530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GUY19_RS07560	COG1595	DNA-templated transcription, initiation
GUY19_RS07580	COG0658	competence protein
GUY19_RS07580	COG2333	competence protein COMEC
GUY19_RS07590	COG1702	phosphate starvation-inducible protein PhoH
GUY19_RS07620	COG0300	oxidoreductase activity
GUY19_RS07635	COG2197	response regulator
GUY19_RS07640	COG0531	amino acid
GUY19_RS07655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUY19_RS07665	COG0420	3'-5' exonuclease activity
GUY19_RS07670	COG0419	ATPase involved in DNA repair
GUY19_RS07680	COG1403	HNH endonuclease
GUY19_RS07690	COG3118	belongs to the thioredoxin family
GUY19_RS07700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUY19_RS07710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GUY19_RS07715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GUY19_RS07735	COG3537	Alpha-1,2-mannosidase
GUY19_RS07765	COG2706	6-phosphogluconolactonase activity
GUY19_RS07780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GUY19_RS07785	COG0616	signal peptide processing
GUY19_RS07790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GUY19_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS07810	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GUY19_RS07845	COG0443	Heat shock 70 kDa protein
GUY19_RS07870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GUY19_RS07875	COG2095	MarC family integral membrane protein
GUY19_RS07880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GUY19_RS07885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GUY19_RS07885	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GUY19_RS07910	COG1027	Aspartate ammonia-lyase
GUY19_RS07915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GUY19_RS07925	COG1506	peptidase
GUY19_RS07925	COG0823	Involved in the tonB-independent uptake of proteins
GUY19_RS07955	COG1301	dicarboxylic acid transport
GUY19_RS07980	COG0671	phosphoesterase, PA-phosphatase related
GUY19_RS07990	COG0671	phosphoesterase, PA-phosphatase related
GUY19_RS08010	COG3275	phosphorelay sensor kinase activity
GUY19_RS08025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GUY19_RS08035	COG1741	Belongs to the pirin family
GUY19_RS08040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GUY19_RS08050	COG1132	(ABC) transporter
GUY19_RS08080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GUY19_RS08090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GUY19_RS08125	COG1428	Deoxynucleoside kinase
GUY19_RS08160	COG0402	S-adenosylhomocysteine deaminase activity
GUY19_RS08190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GUY19_RS08200	COG3590	peptidase
GUY19_RS08205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GUY19_RS08245	COG1722	exodeoxyribonuclease VII activity
GUY19_RS08255	COG3685	Protein conserved in bacteria
GUY19_RS08265	COG0456	acetyltransferase
GUY19_RS08270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUY19_RS08345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GUY19_RS08370	COG0824	Thioesterase
GUY19_RS08375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GUY19_RS08390	COG0009	L-threonylcarbamoyladenylate synthase
GUY19_RS08410	COG0542	response to heat
GUY19_RS08435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GUY19_RS08445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GUY19_RS08455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GUY19_RS08470	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GUY19_RS08500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GUY19_RS08510	COG3237	CsbD-like
GUY19_RS08525	COG0412	Dienelactone hydrolase
GUY19_RS08540	COG1132	(ABC) transporter
GUY19_RS08575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GUY19_RS08595	COG4106	trans-aconitate 2-methyltransferase activity
GUY19_RS08625	COG1132	(ABC) transporter
GUY19_RS08630	COG1215	transferase activity, transferring glycosyl groups
GUY19_RS08650	COG2755	lipolytic protein G-D-S-L family
GUY19_RS08655	COG2755	lipolytic protein G-D-S-L family
GUY19_RS08665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GUY19_RS08670	COG0497	DNA recombination
GUY19_RS08690	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GUY19_RS08705	COG0037	tRNA processing
GUY19_RS08710	COG0039	L-malate dehydrogenase activity
GUY19_RS08740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GUY19_RS08745	COG1472	Belongs to the glycosyl hydrolase 3 family
GUY19_RS08750	COG0438	transferase activity, transferring glycosyl groups
GUY19_RS08760	COG0316	Belongs to the HesB IscA family
GUY19_RS08780	COG4152	abc transporter atp-binding protein
GUY19_RS08785	COG0484	heat shock protein binding
GUY19_RS08790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GUY19_RS08795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GUY19_RS08800	COG0563	adenylate kinase activity
GUY19_RS08810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GUY19_RS08845	COG2030	dehydratase
GUY19_RS08855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GUY19_RS08870	COG0456	acetyltransferase
GUY19_RS08875	COG0463	Glycosyl transferase, family 2
GUY19_RS08885	COG1216	Glycosyl transferase, family 2
GUY19_RS08895	COG1216	Glycosyl transferase, family 2
GUY19_RS08900	COG1216	Glycosyl transferase, family 2
GUY19_RS08920	COG0110	maltose O-acetyltransferase activity
GUY19_RS08935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUY19_RS08940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GUY19_RS08945	COG2244	polysaccharide biosynthetic process
GUY19_RS08960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GUY19_RS08965	COG0463	Glycosyl transferase, family 2
GUY19_RS08975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUY19_RS08990	COG0367	asparagine synthase
GUY19_RS09000	COG0277	FAD linked oxidase domain protein
GUY19_RS09005	COG0791	NLP P60 protein
GUY19_RS09035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GUY19_RS09085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GUY19_RS09115	COG2814	Major facilitator Superfamily
GUY19_RS09125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GUY19_RS09130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUY19_RS09135	COG4558	Periplasmic binding protein
GUY19_RS09150	COG3608	succinylglutamate desuccinylase aspartoacylase
GUY19_RS09150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GUY19_RS09160	COG3591	Belongs to the peptidase S1B family
GUY19_RS09165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GUY19_RS09175	COG4677	pectinesterase activity
GUY19_RS09180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GUY19_RS09190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GUY19_RS09190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GUY19_RS09195	COG0571	ribonuclease III activity
GUY19_RS09200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GUY19_RS09205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GUY19_RS09215	COG0469	pyruvate kinase activity
GUY19_RS09220	COG0268	Binds directly to 16S ribosomal RNA
GUY19_RS09230	COG0429	hydrolase of the alpha beta-hydrolase fold
GUY19_RS09235	COG0357	Ribosomal RNA small subunit methyltransferase G
GUY19_RS09240	COG1595	DNA-templated transcription, initiation
GUY19_RS09250	COG0343	queuine tRNA-ribosyltransferase activity
GUY19_RS09270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GUY19_RS09275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GUY19_RS09290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GUY19_RS09300	COG0626	cystathionine gamma-synthase activity
GUY19_RS09315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GUY19_RS09325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GUY19_RS09330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GUY19_RS09335	COG0193	aminoacyl-tRNA hydrolase activity
GUY19_RS09340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GUY19_RS09340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GUY19_RS09355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GUY19_RS09365	COG1254	Belongs to the acylphosphatase family
GUY19_RS09370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GUY19_RS09375	COG4206	TonB-dependent receptor
GUY19_RS09380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GUY19_RS09385	COG4251	negative regulation of phosphorylation
GUY19_RS09390	COG0784	Response regulator, receiver
GUY19_RS09400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GUY19_RS09410	COG1872	DUF167
GUY19_RS09430	COG0004	ammonium transporteR
GUY19_RS09435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GUY19_RS09450	COG1271	oxidase subunit
GUY19_RS09460	COG3275	phosphorelay sensor kinase activity
GUY19_RS09480	COG4953	penicillin-binding protein 1C
GUY19_RS09485	COG0657	acetylesterase activity
GUY19_RS09485	COG2755	lipolytic protein G-D-S-L family
GUY19_RS09505	COG1012	belongs to the aldehyde dehydrogenase family
GUY19_RS09510	COG2207	Transcriptional regulator
GUY19_RS09510	COG1917	Cupin 2, conserved barrel domain protein
GUY19_RS09520	COG3781	membrane
GUY19_RS09525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GUY19_RS09540	COG1091	dTDP-4-dehydrorhamnose reductase activity
GUY19_RS09565	COG2996	Protein conserved in bacteria
GUY19_RS09570	COG0702	epimerase
GUY19_RS09635	COG4067	protein conserved in archaea
GUY19_RS09635	COG0189	ligase activity
GUY19_RS09670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GUY19_RS09675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GUY19_RS09700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GUY19_RS09715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GUY19_RS09740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUY19_RS09750	COG1418	mRNA catabolic process
GUY19_RS09780	COG2003	Belongs to the UPF0758 family
GUY19_RS09840	COG4251	negative regulation of phosphorylation
GUY19_RS09845	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GUY19_RS09875	COG2197	response regulator
GUY19_RS09910	COG1396	sequence-specific DNA binding
GUY19_RS09910	COG3800	Transcriptional regulator
GUY19_RS09925	COG2217	Heavy metal translocating P-type atpase
GUY19_RS09955	COG1505	serine-type exopeptidase activity
GUY19_RS09960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GUY19_RS09965	COG0612	Peptidase, M16
GUY19_RS09970	COG0538	isocitrate dehydrogenase activity
GUY19_RS10020	COG1064	alcohol dehydrogenase
GUY19_RS10025	COG2814	Major facilitator Superfamily
GUY19_RS10055	COG1515	deoxyribonuclease V activity
GUY19_RS10060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GUY19_RS10085	COG1764	response to oxidative stress
GUY19_RS10090	COG1846	Transcriptional regulator
GUY19_RS10095	COG1741	Belongs to the pirin family
GUY19_RS10105	COG1741	Belongs to the pirin family
GUY19_RS10125	COG1506	peptidase
GUY19_RS10130	COG2885	chlorophyll binding
GUY19_RS10130	COG3047	cAMP biosynthetic process
GUY19_RS10145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUY19_RS10160	COG0288	reversible hydration of carbon dioxide
GUY19_RS10180	COG2354	Protein conserved in bacteria
GUY19_RS10200	COG0542	response to heat
GUY19_RS10230	COG4677	pectinesterase activity
GUY19_RS10270	COG0800	Aldolase
GUY19_RS10295	COG0640	Transcriptional regulator
GUY19_RS10300	COG3411	Ferredoxin
GUY19_RS10305	COG1011	Hydrolase
GUY19_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
GUY19_RS10320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUY19_RS10325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUY19_RS10330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUY19_RS10335	COG0649	NAD binding
GUY19_RS10350	COG1034	ATP synthesis coupled electron transport
GUY19_RS10355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GUY19_RS10360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUY19_RS10385	COG1595	DNA-templated transcription, initiation
GUY19_RS10390	COG0713	ATP synthesis coupled electron transport
GUY19_RS10405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUY19_RS10410	COG1007	ATP synthesis coupled electron transport
GUY19_RS10430	COG2197	response regulator
GUY19_RS10450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GUY19_RS10465	COG3279	Response regulator of the LytR AlgR family
GUY19_RS10470	COG2972	Histidine kinase
GUY19_RS10480	COG1131	(ABC) transporter
GUY19_RS10505	COG1902	pentaerythritol trinitrate reductase activity
GUY19_RS10520	COG2211	Major facilitator Superfamily
GUY19_RS10525	COG0105	UTP biosynthetic process
GUY19_RS10530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GUY19_RS10535	COG0545	Peptidyl-prolyl cis-trans isomerase
GUY19_RS10540	COG0545	Peptidyl-prolyl cis-trans isomerase
GUY19_RS10560	COG1381	Involved in DNA repair and RecF pathway recombination
GUY19_RS10585	COG0772	Belongs to the SEDS family
GUY19_RS10590	COG0768	penicillin binding
GUY19_RS10610	COG0138	bifunctional purine biosynthesis protein purh
GUY19_RS10620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GUY19_RS10655	COG1278	Cold shock
GUY19_RS10660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GUY19_RS10670	COG0633	Ferredoxin
GUY19_RS10690	COG1138	Cytochrome C-type biogenesis protein
GUY19_RS10725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GUY19_RS10730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUY19_RS10735	COG1183	phosphatidylcholine synthase activity
GUY19_RS10750	COG0612	Peptidase, M16
GUY19_RS10790	COG0531	amino acid
GUY19_RS10800	COG1214	PFAM Peptidase M22, glycoprotease
GUY19_RS10825	COG0594	ribonuclease P activity
GUY19_RS10830	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GUY19_RS10865	COG0513	Belongs to the DEAD box helicase family
GUY19_RS10875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GUY19_RS10885	COG2353	YceI-like domain
GUY19_RS10895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GUY19_RS10900	COG1085	galactose-1-phosphate uridylyltransferase
GUY19_RS10925	COG2873	o-acetylhomoserine
GUY19_RS10930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GUY19_RS10935	COG0460	homoserine dehydrogenase
GUY19_RS10945	COG1619	proteins homologs of microcin C7 resistance protein MccF
GUY19_RS10990	COG0779	Required for maturation of 30S ribosomal subunits
GUY19_RS10995	COG0195	Participates in both transcription termination and antitermination
GUY19_RS11000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GUY19_RS11000	COG5180	pathogenesis
GUY19_RS11025	COG2885	chlorophyll binding
GUY19_RS11045	COG1970	mechanosensitive ion channel activity
GUY19_RS11050	COG1024	Enoyl-CoA hydratase
GUY19_RS11060	COG0756	dUTP diphosphatase activity
GUY19_RS11090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GUY19_RS11095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GUY19_RS11105	COG1388	LysM domain
GUY19_RS11105	COG1705	Flagellar rod assembly protein muramidase FlgJ
GUY19_RS11115	COG1045	serine acetyltransferase
GUY19_RS11145	COG0632	four-way junction helicase activity
GUY19_RS11155	COG0509	glycine decarboxylation via glycine cleavage system
GUY19_RS11165	COG2234	aminopeptidase activity
GUY19_RS11175	COG1561	YicC-like family, N-terminal region
GUY19_RS11190	COG0438	transferase activity, transferring glycosyl groups
GUY19_RS11225	COG0714	Associated with various cellular activities
GUY19_RS11270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GUY19_RS11290	COG0484	heat shock protein binding
GUY19_RS11295	COG0861	Integral membrane protein TerC family
GUY19_RS11300	COG1666	GTP binding
GUY19_RS11405	COG2169	Transcriptional regulator
GUY19_RS11435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GUY19_RS11450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GUY19_RS11465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GUY19_RS11470	COG0477	Major facilitator Superfamily
GUY19_RS11490	COG4251	negative regulation of phosphorylation
GUY19_RS11495	COG0436	Aminotransferase
GUY19_RS11510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GUY19_RS11520	COG0438	transferase activity, transferring glycosyl groups
GUY19_RS11530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GUY19_RS11550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GUY19_RS11980	COG0297	glycogen (starch) synthase activity
GUY19_RS12005	COG2226	methyltransferase
GUY19_RS12010	COG1082	Xylose isomerase domain protein TIM barrel
GUY19_RS12025	COG2197	response regulator
GUY19_RS12050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GUY19_RS12060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GUY19_RS12075	COG0612	Peptidase, M16
GUY19_RS12095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GUY19_RS12110	COG3852	Histidine kinase
GUY19_RS12115	COG0492	ferredoxin-NADP+ reductase activity
GUY19_RS12120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GUY19_RS12175	COG2204	response regulator
GUY19_RS12190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GUY19_RS12195	COG1136	(ABC) transporter
GUY19_RS12210	COG4251	negative regulation of phosphorylation
GUY19_RS12225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUY19_RS12240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GUY19_RS12260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GUY19_RS12265	COG0151	Belongs to the GarS family
GUY19_RS12275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GUY19_RS12280	COG0047	phosphoribosylformylglycinamidine synthase activity
GUY19_RS12285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GUY19_RS12295	COG0284	orotidine-5'-phosphate decarboxylase activity
GUY19_RS12300	COG0167	dihydroorotate dehydrogenase activity
GUY19_RS12345	COG5002	protein histidine kinase activity
GUY19_RS12345	COG0784	Response regulator, receiver
GUY19_RS12345	COG2198	Histidine kinase
GUY19_RS12355	COG0577	efflux transmembrane transporter activity
GUY19_RS12355	COG1136	(ABC) transporter
GUY19_RS12365	COG1136	(ABC) transporter
GUY19_RS12365	COG0577	efflux transmembrane transporter activity
GUY19_RS12370	COG1136	(ABC) transporter
GUY19_RS12370	COG0577	efflux transmembrane transporter activity
GUY19_RS12375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUY19_RS12390	COG0693	protein deglycase activity
GUY19_RS12415	COG4251	negative regulation of phosphorylation
GUY19_RS12420	COG0123	including yeast histone deacetylase and acetoin utilization protein
GUY19_RS12430	COG3424	synthase
GUY19_RS12445	COG2072	flavoprotein involved in K transport
GUY19_RS12485	COG2223	nitrite transmembrane transporter activity
GUY19_RS12510	COG1187	pseudouridine synthase activity
GUY19_RS12515	COG1278	Cold shock
GUY19_RS12520	COG2824	Alkylphosphonate utilization operon protein PhnA
GUY19_RS12525	COG4124	Belongs to the glycosyl hydrolase 26 family
GUY19_RS12535	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GUY19_RS12575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUY19_RS12590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUY19_RS12600	COG0697	spore germination
GUY19_RS12615	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUY19_RS12620	COG0567	Dehydrogenase, E1 component
GUY19_RS12675	COG3237	CsbD-like
GUY19_RS12700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GUY19_RS12700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GUY19_RS12715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GUY19_RS12745	COG0022	dehydrogenase e1 component
GUY19_RS12760	COG0612	Peptidase, M16
GUY19_RS12775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GUY19_RS12780	COG1250	3-hydroxyacyl-CoA dehydrogenase
GUY19_RS12800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GUY19_RS12805	COG0601	transmembrane transport
GUY19_RS12820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GUY19_RS12860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUY19_RS12870	COG1295	ribonuclease BN
GUY19_RS12885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GUY19_RS12900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GUY19_RS12900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GUY19_RS12915	COG0848	biopolymer transport protein
GUY19_RS12920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GUY19_RS12925	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GUY19_RS12930	COG2755	lipolytic protein G-D-S-L family
GUY19_RS12930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GUY19_RS12935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GUY19_RS12940	COG0552	protein localization to endoplasmic reticulum
GUY19_RS12950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GUY19_RS12955	COG0006	proline dipeptidase activity
GUY19_RS12960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GUY19_RS12970	COG0251	oxidation-reduction process
GUY19_RS12980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GUY19_RS13000	COG0113	porphobilinogen synthase activity
GUY19_RS13010	COG0531	amino acid
GUY19_RS13025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GUY19_RS13070	COG0300	oxidoreductase activity
GUY19_RS13120	COG0793	Belongs to the peptidase S41A family
GUY19_RS13125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GUY19_RS13130	COG0242	peptide deformylase activity
GUY19_RS13160	COG2972	Histidine kinase
GUY19_RS13170	COG1752	Esterase of the alpha-beta hydrolase superfamily
GUY19_RS13220	COG5002	protein histidine kinase activity
GUY19_RS13230	COG0025	NhaP-type Na H and K H
GUY19_RS13235	COG0488	(ABC) transporter
GUY19_RS13250	COG1120	ATPase activity
GUY19_RS13265	COG1611	Belongs to the LOG family
GUY19_RS13270	COG1136	(ABC) transporter
GUY19_RS13270	COG0577	efflux transmembrane transporter activity
GUY19_RS13275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GUY19_RS13280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GUY19_RS13285	COG1024	Enoyl-CoA hydratase
GUY19_RS13310	COG2135	peptidase activity
GUY19_RS13330	COG2723	6-phospho-beta-galactosidase activity
GUY19_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS13350	COG2885	chlorophyll binding
GUY19_RS13355	COG1233	COG1233 Phytoene dehydrogenase and related
GUY19_RS13365	COG1309	transcriptional regulator
GUY19_RS13400	COG0366	Alpha amylase catalytic
GUY19_RS13405	COG4221	oxidoreductase activity
GUY19_RS13415	COG2211	Major facilitator Superfamily
GUY19_RS13430	COG1649	PFAM Uncharacterised BCR, COG1649
GUY19_RS13440	COG2304	oxidoreductase activity
GUY19_RS13475	COG0432	Pfam Uncharacterised protein family UPF0047
GUY19_RS13485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GUY19_RS13545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GUY19_RS13555	COG2154	pterin-4-alpha-carbinolamine dehydratase
GUY19_RS13580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GUY19_RS13595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GUY19_RS13600	COG0805	protein transport
GUY19_RS13605	COG0698	ribose 5-phosphate isomerase
GUY19_RS13615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GUY19_RS13620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GUY19_RS13625	COG4591	ABC-type transport system involved in lipoprotein release permease component
GUY19_RS13630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GUY19_RS13640	COG0156	8-amino-7-oxononanoate synthase activity
GUY19_RS13655	COG0456	acetyltransferase
GUY19_RS13655	COG0454	-acetyltransferase
GUY19_RS13660	COG1733	regulation of RNA biosynthetic process
GUY19_RS13665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GUY19_RS13685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GUY19_RS13705	COG0860	N-Acetylmuramoyl-L-alanine amidase
GUY19_RS13725	COG1640	4-alpha-glucanotransferase
GUY19_RS13740	COG0492	ferredoxin-NADP+ reductase activity
GUY19_RS13760	COG3387	PFAM Glycoside hydrolase 15-related
GUY19_RS13770	COG3852	Histidine kinase
GUY19_RS13790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GUY19_RS13810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GUY19_RS13815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GUY19_RS13825	COG2852	Protein conserved in bacteria
GUY19_RS13830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GUY19_RS13830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GUY19_RS13910	COG2267	carboxylic ester hydrolase activity
GUY19_RS13920	COG3590	peptidase
GUY19_RS13930	COG1902	pentaerythritol trinitrate reductase activity
GUY19_RS13945	COG2326	polyphosphate kinase activity
GUY19_RS13975	COG3757	hydrolase, family 25
GUY19_RS13980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GUY19_RS14000	COG0484	heat shock protein binding
GUY19_RS14025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GUY19_RS14035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GUY19_RS14040	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GUY19_RS14075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GUY19_RS14075	COG0515	serine threonine protein kinase
GUY19_RS14080	COG1040	competence protein
GUY19_RS14095	COG0708	Exodeoxyribonuclease III
GUY19_RS14110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GUY19_RS14120	COG0445	tRNA wobble uridine modification
GUY19_RS14155	COG0306	phosphate transporter
GUY19_RS14160	COG0423	glycine-tRNA ligase activity
GUY19_RS14180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GUY19_RS14185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GUY19_RS14195	COG0557	exoribonuclease II activity
GUY19_RS14220	COG0584	glycerophosphoryl diester phosphodiesterase
GUY19_RS14235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GUY19_RS14240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GUY19_RS14250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GUY19_RS14255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GUY19_RS14260	COG1187	pseudouridine synthase activity
GUY19_RS14265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GUY19_RS14285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GUY19_RS14295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GUY19_RS14295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GUY19_RS14305	COG1137	ATPase activity
GUY19_RS14335	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GUY19_RS14335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GUY19_RS14350	COG0251	oxidation-reduction process
GUY19_RS14355	COG1250	3-hydroxyacyl-CoA dehydrogenase
GUY19_RS14360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GUY19_RS14370	COG0297	glycogen (starch) synthase activity
GUY19_RS14375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GUY19_RS14380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GUY19_RS14390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GUY19_RS14390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GUY19_RS14400	COG1960	acyl-CoA dehydrogenase activity
GUY19_RS14410	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GUY19_RS14425	COG0484	heat shock protein binding
GUY19_RS14450	COG0247	lactate metabolic process
GUY19_RS14450	COG2181	nitrate reductase activity
GUY19_RS14455	COG2181	nitrate reductase activity
GUY19_RS14455	COG0247	lactate metabolic process
GUY19_RS14465	COG2885	chlorophyll binding
GUY19_RS14480	COG0183	Belongs to the thiolase family
GUY19_RS14490	COG0101	tRNA pseudouridine synthase activity
GUY19_RS14500	COG1132	(ABC) transporter
GUY19_RS14540	COG1132	(ABC) transporter
GUY19_RS14550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GUY19_RS14560	COG0473	3-isopropylmalate dehydrogenase activity
GUY19_RS14570	COG1862	Preprotein translocase
GUY19_RS14580	COG0237	dephospho-CoA kinase activity
GUY19_RS14610	COG0668	transmembrane transport
GUY19_RS14625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GUY19_RS14630	COG3852	Histidine kinase
GUY19_RS14650	COG0531	amino acid
GUY19_RS14685	COG4589	Belongs to the CDS family
GUY19_RS14690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GUY19_RS14695	COG0688	phosphatidylethanolamine metabolic process
GUY19_RS14700	COG0754	glutathionylspermidine amidase activity
GUY19_RS14710	COG1956	GAF domain-containing protein
GUY19_RS14715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GUY19_RS14715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GUY19_RS14720	COG2890	protein-(glutamine-N5) methyltransferase activity
GUY19_RS14730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GUY19_RS14735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GUY19_RS14750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GUY19_RS14790	COG2885	chlorophyll binding
GUY19_RS14795	COG4864	UPF0365 protein
GUY19_RS14820	COG0442	prolyl-tRNA aminoacylation
GUY19_RS14840	COG0823	Involved in the tonB-independent uptake of proteins
GUY19_RS14840	COG1506	peptidase
GUY19_RS14870	COG0463	Glycosyl transferase, family 2
GUY19_RS14875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GUY19_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS14930	COG3844	kynureninase activity
GUY19_RS14950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUY19_RS14970	COG0017	Asparaginyl-tRNA synthetase
GUY19_RS15015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GUY19_RS15025	COG3548	integral membrane protein
GUY19_RS15050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GUY19_RS15090	COG0714	Associated with various cellular activities
GUY19_RS15140	COG1401	restriction endodeoxyribonuclease activity
GUY19_RS15170	COG2814	Major facilitator Superfamily
GUY19_RS15195	COG2366	antibiotic biosynthetic process
GUY19_RS15200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GUY19_RS15250	COG3590	peptidase
GUY19_RS15260	COG2239	Acts as a magnesium transporter
GUY19_RS15285	COG0492	ferredoxin-NADP+ reductase activity
GUY19_RS15295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GUY19_RS15295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GUY19_RS15310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GUY19_RS15310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GUY19_RS15320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GUY19_RS15340	COG1704	LemA family
GUY19_RS15390	COG1505	serine-type exopeptidase activity
GUY19_RS15425	COG2814	Major facilitator Superfamily
GUY19_RS15435	COG4774	siderophore transport
GUY19_RS15450	COG0326	Molecular chaperone. Has ATPase activity
GUY19_RS15460	COG0792	nuclease activity
GUY19_RS15465	COG0321	lipoyl(octanoyl) transferase activity
GUY19_RS15475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GUY19_RS15500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GUY19_RS15520	COG0322	excinuclease ABC activity
GUY19_RS15545	COG0356	it plays a direct role in the translocation of protons across the membrane
GUY19_RS15550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GUY19_RS15555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GUY19_RS15560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GUY19_RS15565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GUY19_RS15570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GUY19_RS15580	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
GUY19_RS15600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GUY19_RS15600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GUY19_RS15610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GUY19_RS15650	COG1139	Iron-sulfur cluster binding protein
GUY19_RS15655	COG2234	aminopeptidase activity
GUY19_RS15660	COG2234	aminopeptidase activity
GUY19_RS15665	COG2234	aminopeptidase activity
GUY19_RS15670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GUY19_RS15685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUY19_RS15690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUY19_RS15695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GUY19_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS15735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GUY19_RS15775	COG4206	TonB-dependent receptor
GUY19_RS15775	COG1629	transport
GUY19_RS15780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GUY19_RS15810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GUY19_RS15815	COG0596	Alpha beta hydrolase
GUY19_RS15835	COG2205	protein histidine kinase activity
GUY19_RS15845	COG0709	Synthesizes selenophosphate from selenide and ATP
GUY19_RS15860	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GUY19_RS15865	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GUY19_RS15900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GUY19_RS15915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GUY19_RS15920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GUY19_RS15935	COG0564	pseudouridine synthase activity
GUY19_RS15945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GUY19_RS15965	COG0848	biopolymer transport protein
GUY19_RS15975	COG0811	peptide transport
GUY19_RS15980	COG3956	TIGRFAM MazG family protein
GUY19_RS15985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GUY19_RS15990	COG1104	cysteine desulfurase activity
GUY19_RS16010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GUY19_RS16015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GUY19_RS16020	COG1160	GTP binding
GUY19_RS16035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GUY19_RS16050	COG1022	Amp-dependent synthetase and ligase
GUY19_RS16065	COG1024	Enoyl-CoA hydratase
GUY19_RS16065	COG1250	3-hydroxyacyl-CoA dehydrogenase
GUY19_RS16070	COG0183	Belongs to the thiolase family
GUY19_RS16075	COG1960	acyl-CoA dehydrogenase activity
GUY19_RS16095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GUY19_RS16105	COG0629	single-stranded DNA binding
GUY19_RS16115	COG0776	regulation of translation
GUY19_RS16125	COG1530	ribonuclease E activity
GUY19_RS16145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GUY19_RS16155	COG1595	DNA-templated transcription, initiation
GUY19_RS16210	COG1073	alpha beta
GUY19_RS16250	COG0149	triose-phosphate isomerase activity
GUY19_RS16260	COG2264	protein methyltransferase activity
GUY19_RS16270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GUY19_RS16320	COG0167	dihydroorotate dehydrogenase activity
GUY19_RS16325	COG0606	chelatase, subunit chli
GUY19_RS16335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GUY19_RS16345	COG1132	(ABC) transporter
GUY19_RS16355	COG1073	alpha beta
GUY19_RS16360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GUY19_RS16395	COG1914	H( )-stimulated, divalent metal cation uptake system
GUY19_RS16450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GUY19_RS16460	COG4974	Belongs to the 'phage' integrase family
GUY19_RS16465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GUY19_RS16470	COG1960	acyl-CoA dehydrogenase activity
GUY19_RS16490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUY19_RS16500	COG1809	phosphosulfolactate synthase activity
GUY19_RS16530	COG0586	Pfam SNARE associated Golgi protein
GUY19_RS16535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GUY19_RS16555	COG1131	(ABC) transporter
GUY19_RS16560	COG2972	Histidine kinase
GUY19_RS16565	COG3279	Response regulator of the LytR AlgR family
GUY19_RS16580	COG0556	nucleotide-excision repair
GUY19_RS16595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GUY19_RS16620	COG3347	Dehydrogenase
GUY19_RS16620	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS16625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GUY19_RS16630	COG4952	isomerase
GUY19_RS16640	COG0247	lactate metabolic process
GUY19_RS16645	COG1139	Iron-sulfur cluster binding protein
GUY19_RS16660	COG3618	amidohydrolase
GUY19_RS16665	COG0179	Fumarylacetoacetate (FAA) hydrolase
GUY19_RS16670	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS16680	COG0025	NhaP-type Na H and K H
GUY19_RS16685	COG0667	Aldo Keto reductase
GUY19_RS16700	COG0656	L-ascorbic acid biosynthetic process
GUY19_RS16740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GUY19_RS16865	COG4771	TonB-dependent receptor
GUY19_RS16870	COG2094	Belongs to the DNA glycosylase MPG family
GUY19_RS16890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GUY19_RS16900	COG0463	Glycosyl transferase, family 2
GUY19_RS16915	COG1595	DNA-templated transcription, initiation
GUY19_RS16925	COG0194	GDP metabolic process
GUY19_RS16930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GUY19_RS16935	COG0233	cytoplasmic translational termination
GUY19_RS16940	COG0528	UMP kinase activity
GUY19_RS16945	COG0511	ligase activity, forming carbon-carbon bonds
GUY19_RS16985	COG0250	Participates in transcription elongation, termination and antitermination
GUY19_RS16990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GUY19_RS16995	COG0081	regulation of translation
GUY19_RS17000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GUY19_RS17005	COG0222	ribosome binding
GUY19_RS17010	COG0085	RNA polymerase activity
GUY19_RS17015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GUY19_RS17035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GUY19_RS17040	COG0049	tRNA binding
GUY19_RS17045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GUY19_RS17050	COG0051	transcription antitermination factor activity, RNA binding
GUY19_RS17060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GUY19_RS17065	COG0088	Forms part of the polypeptide exit tunnel
GUY19_RS17070	COG0089	rRNA binding
GUY19_RS17075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GUY19_RS17080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GUY19_RS17085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GUY19_RS17090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GUY19_RS17095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GUY19_RS17100	COG0255	Belongs to the universal ribosomal protein uL29 family
GUY19_RS17105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GUY19_RS17110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GUY19_RS17115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GUY19_RS17125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GUY19_RS17130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GUY19_RS17135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GUY19_RS17140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GUY19_RS17145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GUY19_RS17150	COG1841	ribosomal large subunit assembly
GUY19_RS17155	COG0200	Binds to the 23S rRNA
GUY19_RS17160	COG0201	protein transport
GUY19_RS17165	COG0024	Methionine aminopeptidase
GUY19_RS17170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GUY19_RS17175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GUY19_RS17180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GUY19_RS17185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GUY19_RS17190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GUY19_RS17195	COG0202	RNA polymerase activity
GUY19_RS17200	COG0203	ribosomal protein L17
GUY19_RS17205	COG0148	phosphopyruvate hydratase activity
GUY19_RS17225	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GUY19_RS17230	COG0443	Heat shock 70 kDa protein
GUY19_RS17270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GUY19_RS17280	COG0116	Belongs to the methyltransferase superfamily
GUY19_RS17280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GUY19_RS17290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GUY19_RS17315	COG0653	protein targeting
GUY19_RS17330	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GUY19_RS17345	COG1473	amidohydrolase
GUY19_RS17370	COG1012	belongs to the aldehyde dehydrogenase family
GUY19_RS17395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GUY19_RS17445	COG2201	protein-glutamate methylesterase activity
GUY19_RS17460	COG0723	plastoquinol--plastocyanin reductase activity
GUY19_RS17465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GUY19_RS17470	COG3781	membrane
GUY19_RS17480	COG0823	Involved in the tonB-independent uptake of proteins
GUY19_RS17480	COG1506	peptidase
GUY19_RS17485	COG0583	DNA-binding transcription factor activity
GUY19_RS17490	COG2855	membrane
GUY19_RS17505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GUY19_RS17510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GUY19_RS17515	COG0052	Belongs to the universal ribosomal protein uS2 family
GUY19_RS17520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GUY19_RS17555	COG5002	protein histidine kinase activity
GUY19_RS17560	COG0745	RESPONSE REGULATOR receiver
GUY19_RS17570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GUY19_RS17585	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS17600	COG0714	Associated with various cellular activities
GUY19_RS17610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GUY19_RS17630	COG0517	IMP dehydrogenase activity
GUY19_RS17630	COG0516	GMP reductase activity
GUY19_RS17650	COG2153	protein acetylation
GUY19_RS17670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GUY19_RS17670	COG0425	Belongs to the sulfur carrier protein TusA family
GUY19_RS17685	COG1643	Atp-dependent helicase
GUY19_RS17690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GUY19_RS17730	COG2255	four-way junction helicase activity
GUY19_RS17740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GUY19_RS17775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GUY19_RS17780	COG3047	cAMP biosynthetic process
GUY19_RS17780	COG2885	chlorophyll binding
GUY19_RS17815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GUY19_RS17830	COG0572	uridine kinase
GUY19_RS17835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GUY19_RS17845	COG0254	rRNA binding
GUY19_RS17860	COG0470	DNA polymerase III
GUY19_RS17885	COG0181	hydroxymethylbilane synthase activity
GUY19_RS17930	COG1774	PSP1 C-terminal conserved region
GUY19_RS17965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GUY19_RS17970	COG1556	Lactate utilization protein
GUY19_RS17980	COG2885	chlorophyll binding
GUY19_RS18000	COG0339	signal peptide processing
GUY19_RS18005	COG0514	ATP-dependent DNA helicase (RecQ)
GUY19_RS18020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GUY19_RS18045	COG0799	negative regulation of ribosome biogenesis
GUY19_RS18050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GUY19_RS18055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GUY19_RS18065	COG4166	transmembrane transport
GUY19_RS18090	COG3279	Response regulator of the LytR AlgR family
GUY19_RS18125	COG2373	Large extracellular alpha-helical protein
GUY19_RS18150	COG0492	ferredoxin-NADP+ reductase activity
GUY19_RS18160	COG0450	alkyl hydroperoxide reductase
GUY19_RS18165	COG0165	Argininosuccinate lyase
GUY19_RS18180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GUY19_RS18190	COG0137	argininosuccinate synthase activity
GUY19_RS18195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GUY19_RS18200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GUY19_RS18205	COG0505	Belongs to the CarA family
GUY19_RS18240	COG1609	Transcriptional regulator
GUY19_RS18265	COG2160	L-arabinose isomerase activity
GUY19_RS18305	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GUY19_RS18320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GUY19_RS18370	COG0626	cystathionine gamma-synthase activity
GUY19_RS18395	COG1830	Aldolase
GUY19_RS18400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GUY19_RS18420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GUY19_RS18425	COG0535	radical SAM domain protein
GUY19_RS18440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GUY19_RS18445	COG1253	flavin adenine dinucleotide binding
GUY19_RS18450	COG4232	protein-disulfide reductase activity
GUY19_RS18460	COG1522	sequence-specific DNA binding
GUY19_RS18470	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GUY19_RS18475	COG3118	belongs to the thioredoxin family
GUY19_RS18495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GUY19_RS18505	COG1705	Flagellar rod assembly protein muramidase FlgJ
GUY19_RS18505	COG1388	LysM domain
GUY19_RS18525	COG0612	Peptidase, M16
GUY19_RS18530	COG0859	PFAM glycosyl transferase family 9
GUY19_RS18540	COG0006	proline dipeptidase activity
GUY19_RS18565	COG1796	DNA polymerase
GUY19_RS18565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GUY19_RS18570	COG0859	PFAM glycosyl transferase family 9
GUY19_RS18595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GUY19_RS18600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GUY19_RS18660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GUY19_RS18670	COG1090	epimerase
GUY19_RS18675	COG0302	gtp cyclohydrolase
GUY19_RS18695	COG0308	aminopeptidase N
GUY19_RS18705	COG0335	large ribosomal subunit rRNA binding
GUY19_RS18710	COG0336	Belongs to the RNA methyltransferase TrmD family
GUY19_RS18715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GUY19_RS18720	COG0228	four-way junction DNA binding
GUY19_RS18730	COG0564	pseudouridine synthase activity
GUY19_RS18735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GUY19_RS18745	COG0860	N-Acetylmuramoyl-L-alanine amidase
GUY19_RS18755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GUY19_RS18775	COG2091	lysine biosynthetic process via aminoadipic acid
GUY19_RS18790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GUY19_RS18815	COG0346	lactoylglutathione lyase activity
GUY19_RS18820	COG1703	isobutyryl-CoA mutase activity
GUY19_RS18835	COG0494	nUDIX hydrolase
GUY19_RS18870	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GUY19_RS18880	COG2259	Doxx family
GUY19_RS18890	COG0488	(ABC) transporter
GUY19_RS18915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUY19_RS18915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUY19_RS18920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUY19_RS18935	COG0737	Belongs to the 5'-nucleotidase family
GUY19_RS18940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GUY19_RS18950	COG1764	response to oxidative stress
GUY19_RS18965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GUY19_RS18970	COG0750	zinc metalloprotease
GUY19_RS18980	COG2885	chlorophyll binding
GUY19_RS18985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GUY19_RS18995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GUY19_RS19000	COG1028	Short-chain dehydrogenase reductase Sdr
GUY19_RS19010	COG4206	TonB-dependent receptor
GUY19_RS19010	COG1629	transport
GUY19_RS19020	COG1629	transport
GUY19_RS19020	COG4206	TonB-dependent receptor
GUY19_RS19045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GUY19_RS19055	COG1136	(ABC) transporter
GUY19_RS19065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GUY19_RS19090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GUY19_RS19095	COG0784	Response regulator, receiver
GUY19_RS19100	COG4251	negative regulation of phosphorylation
GUY19_RS19110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GUY19_RS19120	COG1694	Mazg nucleotide pyrophosphohydrolase
GUY19_RS19125	COG1490	D-aminoacyl-tRNA deacylase activity
GUY19_RS19135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GUY19_RS19145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GUY19_RS19150	COG2224	Isocitrate lyase
GUY19_RS19155	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GUY19_RS19195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GUY19_RS19210	COG2314	TM2 domain
GUY19_RS19215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GUY19_RS19220	COG1331	Highly conserved protein containing a thioredoxin domain
GUY19_RS19230	COG0359	binds to the 23S rRNA
GUY19_RS19235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GUY19_RS19240	COG0360	Binds together with S18 to 16S ribosomal RNA
GUY19_RS19250	COG0437	4 iron, 4 sulfur cluster binding
GUY19_RS19275	COG1565	acr, cog1565
GUY19_RS19275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GUY19_RS19280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GUY19_RS19290	COG0109	protoheme IX farnesyltransferase activity
GUY19_RS19315	COG2322	membrane
GUY19_RS19335	COG5000	phosphorelay sensor kinase activity
GUY19_RS19345	COG2176	DNA-directed DNA polymerase activity
GUY19_RS19365	COG2234	aminopeptidase activity
GUY19_RS19370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GUY19_RS19370	COG3153	acetyltransferase
GUY19_RS19385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GUY19_RS19395	COG0196	riboflavin kinase activity
GUY19_RS19400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GUY19_RS19405	COG1968	undecaprenyl-diphosphatase activity
GUY19_RS19420	COG2177	Part of the ABC transporter FtsEX involved in
GUY19_RS19430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GUY19_RS19440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GUY19_RS19445	COG0791	NLP P60 protein
GUY19_RS19455	COG1476	TRANSCRIPTIONal
GUY19_RS19465	COG3239	Fatty acid desaturase
GUY19_RS19470	COG3239	Fatty acid desaturase
GUY19_RS19505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GUY19_RS19505	COG0189	ligase activity
GUY19_RS19520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GUY19_RS19530	COG2967	ApaG domain
GUY19_RS19535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GUY19_RS19540	COG0681	Belongs to the peptidase S26 family
GUY19_RS19545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GUY19_RS19555	COG1475	DNA binding
GUY19_RS19580	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GUY19_RS19590	COG0504	CTP synthase activity
GUY19_RS19595	COG0706	membrane insertase activity
GUY19_RS19605	COG0747	negative chemotaxis
GUY19_RS19610	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GUY19_RS19615	COG1192	Involved in chromosome partitioning
GUY19_RS19630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GUY19_RS19640	COG2323	membrane
GUY19_RS19650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GUY19_RS19650	COG2207	Transcriptional regulator
GUY19_RS19690	COG4251	negative regulation of phosphorylation
GUY19_RS19695	COG0784	Response regulator, receiver
GUY19_RS19695	COG2205	protein histidine kinase activity
GUY19_RS19700	COG3279	Response regulator of the LytR AlgR family
GUY19_RS19720	COG0667	Aldo Keto reductase
GUY19_RS19725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GUY19_RS19740	COG0405	Gamma-glutamyltransferase
GUY19_RS19745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GUY19_RS19800	COG1649	PFAM Uncharacterised BCR, COG1649
GUY19_RS19815	COG4206	TonB-dependent receptor
GUY19_RS19815	COG1629	transport
GUY19_RS19820	COG0363	glucosamine-6-phosphate deaminase activity
GUY19_RS19825	COG4206	TonB-dependent receptor
GUY19_RS19825	COG1629	transport
GUY19_RS19845	COG1472	Belongs to the glycosyl hydrolase 3 family
GUY19_RS19895	COG0300	oxidoreductase activity
GUY19_RS19940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUY19_RS19960	COG3011	Protein conserved in bacteria
GUY19_RS19970	COG0604	alcohol dehydrogenase
GUY19_RS19980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUY19_RS19985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUY19_RS19995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GUY19_RS20000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUY19_RS20010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GUY19_RS20015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GUY19_RS20020	COG0740	serine-type endopeptidase activity
GUY19_RS20025	COG0544	peptidyl-prolyl cis-trans isomerase activity
GUY19_RS20040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GUY19_RS20050	COG1366	Belongs to the anti-sigma-factor antagonist family
GUY19_RS20055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GUY19_RS20100	COG0463	Glycosyl transferase, family 2
GUY19_RS20115	COG2197	response regulator
GUY19_RS20130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GUY19_RS20140	COG0463	Glycosyl transferase, family 2
GUY19_RS20150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GUY19_RS20170	COG0018	arginyl-trna synthetase
GUY19_RS20180	COG0386	Belongs to the glutathione peroxidase family
GUY19_RS20185	COG1575	Belongs to the MenA family. Type 1 subfamily
GUY19_RS20195	COG3852	Histidine kinase
GUY19_RS20200	COG0745	RESPONSE REGULATOR receiver
GUY19_RS20205	COG4251	negative regulation of phosphorylation
GUY19_RS20215	COG0513	Belongs to the DEAD box helicase family
GUY19_RS20225	COG0673	inositol 2-dehydrogenase activity
GUY19_RS20235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GUY19_RS20245	COG0180	Tryptophanyl-tRNA synthetase
GUY19_RS20275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GUY19_RS20300	COG1288	antiporter activity
GUY19_RS20320	COG4206	TonB-dependent receptor
GUY19_RS20320	COG1629	transport
GUY19_RS20350	COG3852	Histidine kinase
GUY19_RS20355	COG2153	protein acetylation
GUY19_RS20370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GUY19_RS20390	COG3275	phosphorelay sensor kinase activity
GUY19_RS20420	COG3275	phosphorelay sensor kinase activity
GUY19_RS20465	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GUY19_RS20470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GUY19_RS20480	COG2050	protein possibly involved in aromatic compounds catabolism
GUY19_RS20485	COG0406	alpha-ribazole phosphatase activity
GUY19_RS20490	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUY19_RS20500	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GUY19_RS20570	COG0730	response to heat
GUY19_RS20600	COG0488	(ABC) transporter