locus-tag	class	description
HNE_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HNE_RS00010	COG0424	maF-like protein
HNE_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HNE_RS00020	COG0237	dephospho-CoA kinase activity
HNE_RS00030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HNE_RS00075	COG0288	reversible hydration of carbon dioxide
HNE_RS00080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HNE_RS00090	COG4221	oxidoreductase activity
HNE_RS00125	COG1309	transcriptional regulator
HNE_RS00135	COG0071	Belongs to the small heat shock protein (HSP20) family
HNE_RS00145	COG0438	transferase activity, transferring glycosyl groups
HNE_RS00150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HNE_RS00150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HNE_RS00155	COG0588	phosphoglycerate mutase activity
HNE_RS00160	COG2942	2-epimerase
HNE_RS00170	COG1505	serine-type exopeptidase activity
HNE_RS00180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HNE_RS00190	COG0228	four-way junction DNA binding
HNE_RS00205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HNE_RS00220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HNE_RS00220	COG0475	glutathione-regulated potassium exporter activity
HNE_RS00225	COG0336	Belongs to the RNA methyltransferase TrmD family
HNE_RS00230	COG0335	large ribosomal subunit rRNA binding
HNE_RS00235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HNE_RS00240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HNE_RS00245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HNE_RS00260	COG0066	3-isopropylmalate dehydratase activity
HNE_RS00280	COG0473	3-isopropylmalate dehydrogenase activity
HNE_RS00290	COG0640	Transcriptional regulator
HNE_RS00305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HNE_RS00325	COG1024	Enoyl-CoA hydratase
HNE_RS00330	COG0107	imidazoleglycerol-phosphate synthase activity
HNE_RS00350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HNE_RS00355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HNE_RS00360	COG1253	flavin adenine dinucleotide binding
HNE_RS00365	COG0131	Imidazoleglycerol-phosphate dehydratase
HNE_RS00370	COG3300	MHYT domain
HNE_RS00370	COG5001	Diguanylate cyclase
HNE_RS00390	COG2301	Belongs to the HpcH HpaI aldolase family
HNE_RS00395	COG0401	homolog of Blt101
HNE_RS00400	COG4974	Belongs to the 'phage' integrase family
HNE_RS00410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HNE_RS00415	COG4536	flavin adenine dinucleotide binding
HNE_RS00450	COG0702	epimerase
HNE_RS00455	COG1968	undecaprenyl-diphosphatase activity
HNE_RS00475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HNE_RS00480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HNE_RS00505	COG1115	amino acid carrier protein
HNE_RS00510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNE_RS00515	COG1702	phosphate starvation-inducible protein PhoH
HNE_RS00520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HNE_RS00525	COG1253	flavin adenine dinucleotide binding
HNE_RS00530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HNE_RS00535	COG1396	sequence-specific DNA binding
HNE_RS00540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HNE_RS00545	COG1278	Cold shock
HNE_RS00550	COG0779	Required for maturation of 30S ribosomal subunits
HNE_RS00565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HNE_RS00570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HNE_RS00580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HNE_RS00595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNE_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS00635	COG0284	orotidine-5'-phosphate decarboxylase activity
HNE_RS00670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HNE_RS00690	COG0481	GTPase activity
HNE_RS00715	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNE_RS00720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HNE_RS00725	COG0632	four-way junction helicase activity
HNE_RS00730	COG2255	four-way junction helicase activity
HNE_RS00745	COG0824	Thioesterase
HNE_RS00765	COG0823	Involved in the tonB-independent uptake of proteins
HNE_RS00770	COG2885	chlorophyll binding
HNE_RS00800	COG0217	transcriptional regulatory protein
HNE_RS00805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HNE_RS00810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HNE_RS00815	COG4771	TonB-dependent receptor
HNE_RS00825	COG0657	acetylesterase activity
HNE_RS00835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HNE_RS00845	COG0545	Peptidyl-prolyl cis-trans isomerase
HNE_RS00850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HNE_RS00855	COG4172	Belongs to the ABC transporter superfamily
HNE_RS00860	COG3047	cAMP biosynthetic process
HNE_RS00900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HNE_RS00905	COG1522	sequence-specific DNA binding
HNE_RS00925	COG1136	(ABC) transporter
HNE_RS00945	COG1970	mechanosensitive ion channel activity
HNE_RS00950	COG0776	regulation of translation
HNE_RS00955	COG0539	negative regulation of cytoplasmic translation
HNE_RS00960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HNE_RS00965	COG1902	pentaerythritol trinitrate reductase activity
HNE_RS00970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HNE_RS01000	COG1671	Belongs to the UPF0178 family
HNE_RS01005	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HNE_RS01020	COG1137	ATPase activity
HNE_RS01025	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HNE_RS01030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNE_RS01035	COG1957	nucleoside hydrolase
HNE_RS01045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNE_RS01055	COG1538	Outer membrane efflux protein
HNE_RS01175	COG1960	acyl-CoA dehydrogenase activity
HNE_RS01200	COG1766	The M ring may be actively involved in energy transduction
HNE_RS01210	COG1776	CheC inhibitor of MCP methylation
HNE_RS01210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HNE_RS01215	COG1338	Plays a role in the flagellum-specific transport system
HNE_RS01225	COG1706	bacterial-type flagellum-dependent cell motility
HNE_RS01240	COG1749	Flagellar hook protein flgE
HNE_RS01255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HNE_RS01265	COG4786	Flagellar basal body rod
HNE_RS01270	COG4786	Flagellar basal body rod
HNE_RS01280	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HNE_RS01290	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HNE_RS01340	COG1558	bacterial-type flagellum-dependent cell motility
HNE_RS01350	COG1987	bacterial-type flagellum assembly
HNE_RS01355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HNE_RS01360	COG1684	flagellar biosynthetic protein fliR
HNE_RS01365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HNE_RS01380	COG1960	acyl-CoA dehydrogenase activity
HNE_RS01400	COG1595	DNA-templated transcription, initiation
HNE_RS01405	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS01430	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
HNE_RS01480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HNE_RS01495	COG0280	phosphate acetyltransferase
HNE_RS01495	COG0281	malic enzyme
HNE_RS01500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HNE_RS01520	COG0189	ligase activity
HNE_RS01530	COG0799	negative regulation of ribosome biogenesis
HNE_RS01535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HNE_RS01565	COG0045	succinate-CoA ligase (ADP-forming) activity
HNE_RS01570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HNE_RS01575	COG0567	Dehydrogenase, E1 component
HNE_RS01580	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNE_RS01590	COG0625	glutathione transferase activity
HNE_RS01615	COG0583	DNA-binding transcription factor activity
HNE_RS01620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HNE_RS01620	COG1648	precorrin-2 dehydrogenase activity
HNE_RS01630	COG0625	glutathione transferase activity
HNE_RS01635	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HNE_RS01645	COG0175	sulfate reduction
HNE_RS01665	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HNE_RS01690	COG2807	transmembrane transport
HNE_RS01715	COG0714	Associated with various cellular activities
HNE_RS01735	COG0617	tRNA 3'-terminal CCA addition
HNE_RS01750	COG0408	coproporphyrinogen oxidase activity
HNE_RS01775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HNE_RS01790	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNE_RS01795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNE_RS01800	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNE_RS01805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HNE_RS01815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HNE_RS01820	COG1496	oxidoreductase activity
HNE_RS01825	COG1217	gtp-binding protein TYPA
HNE_RS01855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HNE_RS01860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HNE_RS01865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HNE_RS01870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HNE_RS01900	COG2264	protein methyltransferase activity
HNE_RS01910	COG0006	proline dipeptidase activity
HNE_RS01930	COG0497	DNA recombination
HNE_RS01935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HNE_RS01940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HNE_RS01945	COG1396	sequence-specific DNA binding
HNE_RS01950	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HNE_RS01960	COG0849	cell division
HNE_RS01965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HNE_RS01970	COG1181	Belongs to the D-alanine--D-alanine ligase family
HNE_RS01990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HNE_RS02000	COG2205	protein histidine kinase activity
HNE_RS02005	COG1301	dicarboxylic acid transport
HNE_RS02010	COG1643	Atp-dependent helicase
HNE_RS02025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HNE_RS02035	COG0564	pseudouridine synthase activity
HNE_RS02065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HNE_RS02075	COG0706	membrane insertase activity
HNE_RS02080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HNE_RS02095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HNE_RS02110	COG2171	N-acyltransferase activity
HNE_RS02120	COG3920	Histidine kinase
HNE_RS02125	COG0596	Alpha beta hydrolase
HNE_RS02145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HNE_RS02150	COG2202	Pas domain
HNE_RS02150	COG3920	Histidine kinase
HNE_RS02155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HNE_RS02160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HNE_RS02165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HNE_RS02175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNE_RS02175	COG0072	phenylalanine-tRNA ligase activity
HNE_RS02180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HNE_RS02185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HNE_RS02195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HNE_RS02235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HNE_RS02245	COG0440	acetolactate synthase activity
HNE_RS02255	COG0028	Belongs to the TPP enzyme family
HNE_RS02260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HNE_RS02265	COG0560	Phosphoserine phosphatase
HNE_RS02275	COG3034	peptidoglycan biosynthetic process
HNE_RS02280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HNE_RS02295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HNE_RS02305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HNE_RS02325	COG0251	oxidation-reduction process
HNE_RS02335	COG0489	protein tyrosine kinase activity
HNE_RS02340	COG0330	HflC and HflK could
HNE_RS02345	COG0330	HflC and HflK could
HNE_RS02355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HNE_RS02375	COG2070	2-Nitropropane dioxygenase
HNE_RS02390	COG3023	N-Acetylmuramoyl-L-alanine amidase
HNE_RS02395	COG0697	spore germination
HNE_RS02410	COG0730	response to heat
HNE_RS02450	COG5001	Diguanylate cyclase
HNE_RS02450	COG3300	MHYT domain
HNE_RS02485	COG0542	response to heat
HNE_RS02500	COG2095	MarC family integral membrane protein
HNE_RS02520	COG2353	YceI-like domain
HNE_RS02550	COG1322	Protein conserved in bacteria
HNE_RS02555	COG0242	peptide deformylase activity
HNE_RS02560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HNE_RS02570	COG0101	tRNA pseudouridine synthase activity
HNE_RS02575	COG1960	acyl-CoA dehydrogenase activity
HNE_RS02585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HNE_RS02595	COG0180	Tryptophanyl-tRNA synthetase
HNE_RS02605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HNE_RS02610	COG0778	Nitroreductase
HNE_RS02640	COG2133	pyrroloquinoline quinone binding
HNE_RS02645	COG4771	TonB-dependent receptor
HNE_RS02650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HNE_RS02655	COG0602	queuosine metabolic process
HNE_RS02675	COG1741	Belongs to the pirin family
HNE_RS02700	COG0514	ATP-dependent DNA helicase (RecQ)
HNE_RS02705	COG0740	serine-type endopeptidase activity
HNE_RS02715	COG1752	Esterase of the alpha-beta hydrolase superfamily
HNE_RS02725	COG0579	oxidoreductase
HNE_RS02735	COG0492	ferredoxin-NADP+ reductase activity
HNE_RS02760	COG0513	Belongs to the DEAD box helicase family
HNE_RS02765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HNE_RS02770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HNE_RS02800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HNE_RS02815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HNE_RS02820	COG0268	Binds directly to 16S ribosomal RNA
HNE_RS02825	COG1024	Enoyl-CoA hydratase
HNE_RS02835	COG0671	phosphoesterase, PA-phosphatase related
HNE_RS02865	COG0861	Integral membrane protein TerC family
HNE_RS02870	COG2059	Chromate
HNE_RS02875	COG0124	histidyl-tRNA synthetase
HNE_RS02880	COG0124	histidyl-tRNA synthetase
HNE_RS02885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HNE_RS02890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HNE_RS02900	COG1672	PFAM Archaeal ATPase
HNE_RS02900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HNE_RS02930	COG2329	Antibiotic biosynthesis monooxygenase
HNE_RS02945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HNE_RS02970	COG0668	transmembrane transport
HNE_RS02975	COG0668	transmembrane transport
HNE_RS03005	COG1201	RNA secondary structure unwinding
HNE_RS03040	COG0659	secondary active sulfate transmembrane transporter activity
HNE_RS03055	COG0076	glutamate decarboxylase activity
HNE_RS03075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HNE_RS03095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HNE_RS03120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HNE_RS03135	COG2890	protein-(glutamine-N5) methyltransferase activity
HNE_RS03145	COG0542	response to heat
HNE_RS03160	COG0739	heme binding
HNE_RS03200	COG0482	sulfurtransferase activity
HNE_RS03205	COG3660	Nucleoside-diphosphate-sugar epimerase
HNE_RS03210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HNE_RS03215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HNE_RS03240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNE_RS03250	COG1309	transcriptional regulator
HNE_RS03255	COG1448	Aminotransferase
HNE_RS03270	COG0735	belongs to the Fur family
HNE_RS03285	COG3474	cytochrome
HNE_RS03315	COG2816	NAD+ diphosphatase activity
HNE_RS03335	COG1960	acyl-CoA dehydrogenase activity
HNE_RS03350	COG0183	Belongs to the thiolase family
HNE_RS03355	COG1024	Enoyl-CoA hydratase
HNE_RS03355	COG1250	3-hydroxyacyl-CoA dehydrogenase
HNE_RS03360	COG1530	ribonuclease E activity
HNE_RS03365	COG0860	N-Acetylmuramoyl-L-alanine amidase
HNE_RS03365	COG1388	LysM domain
HNE_RS03375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HNE_RS03380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HNE_RS03385	COG0142	geranyltranstransferase activity
HNE_RS03415	COG0751	glycine-tRNA ligase activity
HNE_RS03420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HNE_RS03420	COG0574	Belongs to the PEP-utilizing enzyme family
HNE_RS03430	COG4221	oxidoreductase activity
HNE_RS03440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HNE_RS03465	COG0513	Belongs to the DEAD box helicase family
HNE_RS03470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HNE_RS03490	COG1663	tetraacyldisaccharide 4'-kinase activity
HNE_RS03515	COG0546	phosphoglycolate phosphatase activity
HNE_RS03520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HNE_RS03525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HNE_RS03535	COG1192	Involved in chromosome partitioning
HNE_RS03540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HNE_RS03550	COG0534	Mate efflux family protein
HNE_RS03565	COG2130	NADP-dependent
HNE_RS03570	COG0673	inositol 2-dehydrogenase activity
HNE_RS03580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HNE_RS03610	COG1127	ABC transporter
HNE_RS03615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HNE_RS03620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HNE_RS03645	COG2212	antiporter activity
HNE_RS03650	COG1320	monovalent cation:proton antiporter activity
HNE_RS03670	COG0651	ATP synthesis coupled electron transport
HNE_RS03685	COG0651	ATP synthesis coupled electron transport
HNE_RS03690	COG4957	zinc ion binding
HNE_RS03700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HNE_RS03710	COG2166	iron-sulfur cluster assembly
HNE_RS03750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HNE_RS03760	COG0488	(ABC) transporter
HNE_RS03770	COG2813	Specifically methylates the guanine in position
HNE_RS03780	COG0183	Belongs to the thiolase family
HNE_RS03795	COG0484	heat shock protein binding
HNE_RS03805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HNE_RS03810	COG0792	nuclease activity
HNE_RS03820	COG1216	Glycosyl transferase, family 2
HNE_RS03830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HNE_RS03835	COG3706	GGDEF domain
HNE_RS03845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HNE_RS03860	COG1160	GTP binding
HNE_RS03865	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HNE_RS03865	COG0662	Cupin 2, conserved barrel domain protein
HNE_RS03875	COG0175	sulfate reduction
HNE_RS03880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HNE_RS03885	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HNE_RS03890	COG1091	dTDP-4-dehydrorhamnose reductase activity
HNE_RS03915	COG1595	DNA-templated transcription, initiation
HNE_RS03920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HNE_RS03930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HNE_RS03935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HNE_RS03940	COG1088	dTDP-glucose 4,6-dehydratase activity
HNE_RS03995	COG0463	Glycosyl transferase, family 2
HNE_RS04020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HNE_RS04035	COG1960	acyl-CoA dehydrogenase activity
HNE_RS04040	COG3033	Beta-eliminating lyase
HNE_RS04075	COG0154	amidase activity
HNE_RS04100	COG2226	methyltransferase
HNE_RS04110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HNE_RS04115	COG0259	pyridoxamine-phosphate oxidase activity
HNE_RS04130	COG0584	glycerophosphoryl diester phosphodiesterase
HNE_RS04135	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS04160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNE_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS04190	COG0179	Fumarylacetoacetate (FAA) hydrolase
HNE_RS04210	COG2030	dehydratase
HNE_RS04215	COG0196	riboflavin kinase activity
HNE_RS04230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HNE_RS04235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HNE_RS04245	COG0612	Peptidase, M16
HNE_RS04260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HNE_RS04280	COG2818	Glycosylase
HNE_RS04285	COG0354	folic acid binding
HNE_RS04290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HNE_RS04300	COG3321	synthase
HNE_RS04300	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS04300	COG0300	oxidoreductase activity
HNE_RS04300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HNE_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS04305	COG0028	Belongs to the TPP enzyme family
HNE_RS04310	COG1506	peptidase
HNE_RS04310	COG4946	Tricorn protease homolog
HNE_RS04310	COG0823	Involved in the tonB-independent uptake of proteins
HNE_RS04325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HNE_RS04325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HNE_RS04340	COG1758	RNA polymerase activity
HNE_RS04350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HNE_RS04355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HNE_RS04360	COG0736	holo-[acyl-carrier-protein] synthase activity
HNE_RS04365	COG0571	ribonuclease III activity
HNE_RS04375	COG1381	Involved in DNA repair and RecF pathway recombination
HNE_RS04385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HNE_RS04390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HNE_RS04410	COG1704	LemA family
HNE_RS04425	COG0436	Aminotransferase
HNE_RS04430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HNE_RS04440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HNE_RS04445	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HNE_RS04450	COG1360	Flagellar Motor Protein
HNE_RS04455	COG2084	Dehydrogenase
HNE_RS04465	COG1047	Peptidyl-prolyl cis-trans
HNE_RS04470	COG0113	porphobilinogen synthase activity
HNE_RS04480	COG1960	acyl-CoA dehydrogenase activity
HNE_RS04505	COG2175	clavaminate synthase activity
HNE_RS04515	COG1024	Enoyl-CoA hydratase
HNE_RS04520	COG2076	Multidrug Resistance protein
HNE_RS04550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HNE_RS04565	COG0277	FAD linked oxidase domain protein
HNE_RS04585	COG1570	exodeoxyribonuclease VII activity
HNE_RS04590	COG2226	methyltransferase
HNE_RS04600	COG1063	alcohol dehydrogenase
HNE_RS04605	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS04650	COG1228	amidohydrolase
HNE_RS04655	COG2885	chlorophyll binding
HNE_RS04665	COG1024	Enoyl-CoA hydratase
HNE_RS04680	COG1187	pseudouridine synthase activity
HNE_RS04705	COG0328	RNA-DNA hybrid ribonuclease activity
HNE_RS04715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HNE_RS04720	COG2814	Major facilitator Superfamily
HNE_RS04725	COG2814	Major facilitator Superfamily
HNE_RS04730	COG0488	(ABC) transporter
HNE_RS04740	COG0024	Methionine aminopeptidase
HNE_RS04750	COG1058	Belongs to the CinA family
HNE_RS04750	COG1546	Belongs to the CinA family
HNE_RS04765	COG3384	dioxygenase
HNE_RS04770	COG0183	Belongs to the thiolase family
HNE_RS04775	COG1278	Cold shock
HNE_RS04785	COG0471	metal ion transport
HNE_RS04795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HNE_RS04795	COG0617	tRNA 3'-terminal CCA addition
HNE_RS04795	COG0517	IMP dehydrogenase activity
HNE_RS04800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HNE_RS04815	COG1741	Belongs to the pirin family
HNE_RS04825	COG0686	Belongs to the AlaDH PNT family
HNE_RS04845	COG0187	DNA topoisomerase II activity
HNE_RS04865	COG2072	flavoprotein involved in K transport
HNE_RS04870	COG1024	Enoyl-CoA hydratase
HNE_RS04875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HNE_RS04890	COG0596	Alpha beta hydrolase
HNE_RS04905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNE_RS04915	COG0431	NADPH-dependent FMN reductase
HNE_RS04925	COG0798	PFAM Bile acid sodium symporter
HNE_RS04945	COG0589	response to stress
HNE_RS04950	COG0659	secondary active sulfate transmembrane transporter activity
HNE_RS04965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HNE_RS04970	COG0564	pseudouridine synthase activity
HNE_RS04975	COG0546	phosphoglycolate phosphatase activity
HNE_RS04995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HNE_RS05000	COG0402	S-adenosylhomocysteine deaminase activity
HNE_RS05025	COG1846	Transcriptional regulator
HNE_RS05055	COG5507	3-demethylubiquinone-9 3-methyltransferase
HNE_RS05075	COG2968	Membrane
HNE_RS05080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HNE_RS05080	COG0517	IMP dehydrogenase activity
HNE_RS05105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HNE_RS05115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HNE_RS05130	COG0312	modulator of DNA gyrase
HNE_RS05150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HNE_RS05155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HNE_RS05160	COG0109	protoheme IX farnesyltransferase activity
HNE_RS05165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HNE_RS05215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HNE_RS05215	COG0678	peroxiredoxin activity
HNE_RS05220	COG0330	HflC and HflK could
HNE_RS05245	COG4770	biotin carboxylase activity
HNE_RS05265	COG0321	lipoyl(octanoyl) transferase activity
HNE_RS05280	COG0315	cyclic pyranopterin monophosphate synthase activity
HNE_RS05285	COG0521	Mo-molybdopterin cofactor biosynthetic process
HNE_RS05290	COG0314	molybdopterin synthase activity
HNE_RS05300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HNE_RS05310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HNE_RS05315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HNE_RS05320	COG2080	2 iron, 2 sulfur cluster binding
HNE_RS05330	COG0693	protein deglycase activity
HNE_RS05340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HNE_RS05350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HNE_RS05355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HNE_RS05360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNE_RS05375	COG4774	siderophore transport
HNE_RS05390	COG2130	NADP-dependent
HNE_RS05415	COG0500	methyltransferase
HNE_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS05450	COG1960	acyl-CoA dehydrogenase activity
HNE_RS05455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HNE_RS05485	COG0154	amidase activity
HNE_RS05490	COG1024	Enoyl-CoA hydratase
HNE_RS05495	COG1012	belongs to the aldehyde dehydrogenase family
HNE_RS05510	COG2188	Transcriptional regulator
HNE_RS05520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNE_RS05535	COG1335	isochorismatase
HNE_RS05540	COG4771	TonB-dependent receptor
HNE_RS05545	COG0513	Belongs to the DEAD box helicase family
HNE_RS05560	COG1609	Transcriptional regulator
HNE_RS05570	COG0583	DNA-binding transcription factor activity
HNE_RS05575	COG1609	Transcriptional regulator
HNE_RS05580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HNE_RS05585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HNE_RS05595	COG0489	protein tyrosine kinase activity
HNE_RS05605	COG0343	queuine tRNA-ribosyltransferase activity
HNE_RS05625	COG1960	acyl-CoA dehydrogenase activity
HNE_RS05635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HNE_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS05680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HNE_RS05685	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HNE_RS05695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HNE_RS05710	COG4964	Belongs to the GSP D family
HNE_RS05740	COG0825	malonyl-CoA metabolic process
HNE_RS05750	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HNE_RS05765	COG0416	fatty acid biosynthetic process
HNE_RS05770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HNE_RS05775	COG0776	regulation of translation
HNE_RS05790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNE_RS05840	COG0538	isocitrate dehydrogenase activity
HNE_RS05845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HNE_RS05860	COG1024	Enoyl-CoA hydratase
HNE_RS05865	COG1960	acyl-CoA dehydrogenase activity
HNE_RS05870	COG1960	acyl-CoA dehydrogenase activity
HNE_RS05885	COG0800	Aldolase
HNE_RS05910	COG1304	FMN binding
HNE_RS05920	COG3206	protein involved in exopolysaccharide biosynthesis
HNE_RS05920	COG0489	protein tyrosine kinase activity
HNE_RS05925	COG0438	transferase activity, transferring glycosyl groups
HNE_RS05955	COG1215	transferase activity, transferring glycosyl groups
HNE_RS05975	COG0714	Associated with various cellular activities
HNE_RS06000	COG1956	GAF domain-containing protein
HNE_RS06010	COG0626	cystathionine gamma-synthase activity
HNE_RS06050	COG0154	amidase activity
HNE_RS06080	COG2217	Heavy metal translocating P-type atpase
HNE_RS06095	COG2010	Cytochrome c
HNE_RS06110	COG3278	Belongs to the heme-copper respiratory oxidase family
HNE_RS06120	COG4191	Histidine kinase
HNE_RS06140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HNE_RS06160	COG5265	(ABC) transporter
HNE_RS06190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HNE_RS06195	COG0156	8-amino-7-oxononanoate synthase activity
HNE_RS06200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HNE_RS06215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HNE_RS06230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HNE_RS06240	COG1335	isochorismatase
HNE_RS06270	COG4585	Histidine kinase
HNE_RS06295	COG2072	flavoprotein involved in K transport
HNE_RS06300	COG2239	Acts as a magnesium transporter
HNE_RS06310	COG1960	acyl-CoA dehydrogenase activity
HNE_RS06335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HNE_RS06355	COG1024	Enoyl-CoA hydratase
HNE_RS06365	COG3739	integral membrane protein
HNE_RS06375	COG2072	flavoprotein involved in K transport
HNE_RS06405	COG1234	tRNA 3'-trailer cleavage
HNE_RS06415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HNE_RS06445	COG1192	Involved in chromosome partitioning
HNE_RS06500	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HNE_RS06505	COG1138	Cytochrome C-type biogenesis protein
HNE_RS06510	COG2205	protein histidine kinase activity
HNE_RS06515	COG0745	RESPONSE REGULATOR receiver
HNE_RS06525	COG3088	subunit of a heme lyase
HNE_RS06535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HNE_RS06570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HNE_RS06580	COG0393	Putative heavy-metal-binding
HNE_RS06615	COG0024	Methionine aminopeptidase
HNE_RS06625	COG0154	amidase activity
HNE_RS06630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HNE_RS06635	COG0823	Involved in the tonB-independent uptake of proteins
HNE_RS06635	COG1506	peptidase
HNE_RS06640	COG4206	TonB-dependent receptor
HNE_RS06665	COG2124	cytochrome p450
HNE_RS06670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HNE_RS06680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HNE_RS06685	COG5328	Belongs to the UPF0262 family
HNE_RS06710	COG3279	Response regulator of the LytR AlgR family
HNE_RS06720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HNE_RS06725	COG0424	maF-like protein
HNE_RS06765	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HNE_RS06770	COG0312	modulator of DNA gyrase
HNE_RS06780	COG1132	(ABC) transporter
HNE_RS06790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HNE_RS06800	COG2814	Major facilitator Superfamily
HNE_RS06805	COG0667	Aldo Keto reductase
HNE_RS06810	COG0583	DNA-binding transcription factor activity
HNE_RS06815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HNE_RS06825	COG2135	peptidase activity
HNE_RS06830	COG3104	oligopeptide transport
HNE_RS06835	COG0668	transmembrane transport
HNE_RS06845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HNE_RS06860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HNE_RS06870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HNE_RS06910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HNE_RS06925	COG3186	Phenylalanine-4-hydroxylase
HNE_RS06930	COG0193	aminoacyl-tRNA hydrolase activity
HNE_RS06935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HNE_RS06955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNE_RS06960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HNE_RS06965	COG1215	transferase activity, transferring glycosyl groups
HNE_RS06970	COG0642	Histidine kinase
HNE_RS06990	COG0745	RESPONSE REGULATOR receiver
HNE_RS06995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HNE_RS07005	COG0129	dihydroxy-acid dehydratase activity
HNE_RS07010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HNE_RS07010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HNE_RS07025	COG2130	NADP-dependent
HNE_RS07040	COG0626	cystathionine gamma-synthase activity
HNE_RS07045	COG2897	thiosulfate sulfurtransferase activity
HNE_RS07060	COG3046	protein related to deoxyribodipyrimidine photolyase
HNE_RS07085	COG1396	sequence-specific DNA binding
HNE_RS07090	COG4974	Belongs to the 'phage' integrase family
HNE_RS07120	COG2072	flavoprotein involved in K transport
HNE_RS07130	COG5489	Protein of unknown function (DUF736)
HNE_RS07160	COG2274	protein secretion by the type I secretion system
HNE_RS07165	COG1525	nuclease
HNE_RS07175	COG2197	response regulator
HNE_RS07225	COG0583	DNA-binding transcription factor activity
HNE_RS07265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HNE_RS07270	COG0583	DNA-binding transcription factor activity
HNE_RS07275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HNE_RS07295	COG0235	Class ii aldolase
HNE_RS07300	COG2211	Major facilitator Superfamily
HNE_RS07305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HNE_RS07310	COG0066	3-isopropylmalate dehydratase activity
HNE_RS07315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HNE_RS07320	COG3300	MHYT domain
HNE_RS07320	COG5001	Diguanylate cyclase
HNE_RS07365	COG1937	Protein conserved in bacteria
HNE_RS07395	COG0583	DNA-binding transcription factor activity
HNE_RS07405	COG2815	serine threonine protein kinase
HNE_RS07405	COG0515	serine threonine protein kinase
HNE_RS07450	COG1309	transcriptional regulator
HNE_RS07470	COG0784	Response regulator, receiver
HNE_RS07470	COG2205	protein histidine kinase activity
HNE_RS07470	COG5002	protein histidine kinase activity
HNE_RS07480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HNE_RS07485	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HNE_RS07515	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HNE_RS07520	COG1492	cobalamin metabolic process
HNE_RS07525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HNE_RS07580	COG0583	DNA-binding transcription factor activity
HNE_RS07585	COG3177	Filamentation induced by cAMP protein fic
HNE_RS07590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNE_RS07595	COG1131	(ABC) transporter
HNE_RS07600	COG0842	Transport permease protein
HNE_RS07605	COG0842	Transport permease protein
HNE_RS07620	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HNE_RS07660	COG0314	molybdopterin synthase activity
HNE_RS07665	COG0521	Mo-molybdopterin cofactor biosynthetic process
HNE_RS07670	COG0315	cyclic pyranopterin monophosphate synthase activity
HNE_RS07675	COG0303	'Molybdopterin
HNE_RS07685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HNE_RS07695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HNE_RS07705	COG2223	nitrite transmembrane transporter activity
HNE_RS07710	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HNE_RS07715	COG1140	nitrate reductase beta subunit
HNE_RS07720	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HNE_RS07730	COG2181	nitrate reductase activity
HNE_RS07745	COG0288	reversible hydration of carbon dioxide
HNE_RS07750	COG0746	molybdenum cofactor guanylyltransferase activity
HNE_RS07765	COG1960	acyl-CoA dehydrogenase activity
HNE_RS07775	COG1024	Enoyl-CoA hydratase
HNE_RS07775	COG1250	3-hydroxyacyl-CoA dehydrogenase
HNE_RS07805	COG1213	nucleotidyl transferase
HNE_RS07830	COG0456	acetyltransferase
HNE_RS07865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HNE_RS07875	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS07890	COG0582	viral genome integration into host DNA
HNE_RS07915	COG0154	amidase activity
HNE_RS07920	COG1063	alcohol dehydrogenase
HNE_RS07950	COG5505	Protein of unknown function (DUF819)
HNE_RS07955	COG4948	Mandelate Racemase Muconate Lactonizing
HNE_RS07960	COG4771	TonB-dependent receptor
HNE_RS07965	COG1522	sequence-specific DNA binding
HNE_RS07980	COG0730	response to heat
HNE_RS07995	COG0427	acetyl-CoA hydrolase
HNE_RS08015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HNE_RS08020	COG3128	pkhd-type hydroxylase
HNE_RS08035	COG2119	membrane
HNE_RS08050	COG0515	serine threonine protein kinase
HNE_RS08050	COG2815	serine threonine protein kinase
HNE_RS08090	COG0456	acetyltransferase
HNE_RS08095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HNE_RS08100	COG1917	Cupin 2, conserved barrel domain protein
HNE_RS08105	COG5285	phytanoyl-CoA dioxygenase
HNE_RS08110	COG0527	aspartate kinase activity
HNE_RS08120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNE_RS08125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNE_RS08130	COG0577	efflux transmembrane transporter activity
HNE_RS08130	COG1136	(ABC) transporter
HNE_RS08165	COG4771	TonB-dependent receptor
HNE_RS08170	COG0277	FAD linked oxidase domain protein
HNE_RS08190	COG1294	oxidase, subunit
HNE_RS08195	COG1271	oxidase subunit
HNE_RS08200	COG4988	ABC transporter
HNE_RS08205	COG2274	protein secretion by the type I secretion system
HNE_RS08230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HNE_RS08235	COG3119	arylsulfatase activity
HNE_RS08250	COG1793	dna ligase
HNE_RS08255	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HNE_RS08275	COG1446	asparaginase
HNE_RS08280	COG0525	valine-tRNA ligase activity
HNE_RS08295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HNE_RS08325	COG1733	regulation of RNA biosynthetic process
HNE_RS08360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNE_RS08385	COG1595	DNA-templated transcription, initiation
HNE_RS08430	COG2132	Multicopper oxidase
HNE_RS08445	COG1937	Protein conserved in bacteria
HNE_RS08480	COG5489	Protein of unknown function (DUF736)
HNE_RS08490	COG2948	multi-organism process
HNE_RS08530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HNE_RS08535	COG0582	viral genome integration into host DNA
HNE_RS08545	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HNE_RS08550	COG1530	ribonuclease E activity
HNE_RS08555	COG0166	Belongs to the GPI family
HNE_RS08560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HNE_RS08575	COG0366	Alpha amylase catalytic
HNE_RS08580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HNE_RS08590	COG0129	dihydroxy-acid dehydratase activity
HNE_RS08595	COG0837	glucose binding
HNE_RS08600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNE_RS08605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNE_RS08610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNE_RS08615	COG0649	NAD binding
HNE_RS08630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HNE_RS08635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HNE_RS08650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HNE_RS08655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNE_RS08665	COG0713	ATP synthesis coupled electron transport
HNE_RS08680	COG1007	ATP synthesis coupled electron transport
HNE_RS08690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HNE_RS08700	COG0346	lactoylglutathione lyase activity
HNE_RS08710	COG0442	prolyl-tRNA aminoacylation
HNE_RS08720	COG1136	(ABC) transporter
HNE_RS08730	COG0052	Belongs to the universal ribosomal protein uS2 family
HNE_RS08735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HNE_RS08740	COG0528	UMP kinase activity
HNE_RS08745	COG0233	cytoplasmic translational termination
HNE_RS08750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HNE_RS08760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HNE_RS08765	COG0750	zinc metalloprotease
HNE_RS08780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNE_RS08785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNE_RS08790	COG3494	Protein of unknown function (DUF1009)
HNE_RS08795	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNE_RS08800	COG0372	Belongs to the citrate synthase family
HNE_RS08805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HNE_RS08820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HNE_RS08825	COG0134	indole-3-glycerol-phosphate synthase activity
HNE_RS08830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HNE_RS08840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HNE_RS08850	COG0149	triose-phosphate isomerase activity
HNE_RS08860	COG0504	CTP synthase activity
HNE_RS08865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HNE_RS08880	COG0415	Belongs to the DNA photolyase family
HNE_RS08885	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HNE_RS08885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HNE_RS08895	COG0248	Ppx GppA phosphatase
HNE_RS08900	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HNE_RS08920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HNE_RS08920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HNE_RS08930	COG0519	Catalyzes the synthesis of GMP from XMP
HNE_RS08930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HNE_RS08940	COG0321	lipoyl(octanoyl) transferase activity
HNE_RS08940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HNE_RS08945	COG0084	hydrolase, TatD family'
HNE_RS08955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HNE_RS08960	COG1686	Belongs to the peptidase S11 family
HNE_RS09015	COG1024	Enoyl-CoA hydratase
HNE_RS09030	COG1024	Enoyl-CoA hydratase
HNE_RS09050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNE_RS09065	COG0667	Aldo Keto reductase
HNE_RS09070	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS09085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HNE_RS09090	COG0142	geranyltranstransferase activity
HNE_RS09095	COG1722	exodeoxyribonuclease VII activity
HNE_RS09115	COG1187	pseudouridine synthase activity
HNE_RS09120	COG1960	acyl-CoA dehydrogenase activity
HNE_RS09125	COG2353	YceI-like domain
HNE_RS09135	COG0009	L-threonylcarbamoyladenylate synthase
HNE_RS09155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNE_RS09170	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HNE_RS09235	COG1459	type II secretion system
HNE_RS09240	COG2165	general secretion pathway protein
HNE_RS09290	COG1760	l-serine dehydratase
HNE_RS09295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNE_RS09305	COG1131	(ABC) transporter
HNE_RS09325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HNE_RS09330	COG3178	'Phosphotransferase
HNE_RS09335	COG0802	atpase or kinase
HNE_RS09345	COG0633	Ferredoxin
HNE_RS09355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HNE_RS09360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HNE_RS09365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HNE_RS09370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HNE_RS09375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HNE_RS09385	COG1309	transcriptional regulator
HNE_RS09395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HNE_RS09440	COG1573	uracil-dna glycosylase
HNE_RS09455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HNE_RS09460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HNE_RS09470	COG1194	a g-specific adenine glycosylase
HNE_RS09480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HNE_RS09495	COG0356	it plays a direct role in the translocation of protons across the membrane
HNE_RS09500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HNE_RS09510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HNE_RS09520	COG0012	GTP binding
HNE_RS09525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HNE_RS09530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HNE_RS09535	COG1862	Preprotein translocase
HNE_RS09540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HNE_RS09545	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HNE_RS09550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HNE_RS09560	COG0805	protein transport
HNE_RS09565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HNE_RS09585	COG0047	phosphoribosylformylglycinamidine synthase activity
HNE_RS09590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HNE_RS09610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HNE_RS09630	COG0271	Belongs to the BolA IbaG family
HNE_RS09645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HNE_RS09655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNE_RS09665	COG4977	sequence-specific DNA binding
HNE_RS09675	COG2326	polyphosphate kinase activity
HNE_RS09680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HNE_RS09695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HNE_RS09705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HNE_RS09710	COG0459	protein refolding
HNE_RS09730	COG1278	Cold shock
HNE_RS09740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HNE_RS09740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HNE_RS09745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HNE_RS09755	COG1757	Na H antiporter
HNE_RS09770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HNE_RS09775	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNE_RS09780	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNE_RS09780	COG0022	dehydrogenase e1 component
HNE_RS09785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HNE_RS09795	COG2203	Gaf domain
HNE_RS09795	COG3706	GGDEF domain
HNE_RS09795	COG4251	negative regulation of phosphorylation
HNE_RS09795	COG5001	Diguanylate cyclase
HNE_RS09800	COG0148	phosphopyruvate hydratase activity
HNE_RS09805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HNE_RS09815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HNE_RS09825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HNE_RS09835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HNE_RS09845	COG3231	kanamycin kinase activity
HNE_RS09865	COG3724	N-succinylarginine dihydrolase activity
HNE_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
HNE_RS09890	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HNE_RS09890	COG2885	chlorophyll binding
HNE_RS09920	COG3956	TIGRFAM MazG family protein
HNE_RS09925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HNE_RS09930	COG1923	regulation of RNA biosynthetic process
HNE_RS09935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HNE_RS09940	COG0569	domain protein
HNE_RS09945	COG2204	response regulator
HNE_RS09950	COG5000	phosphorelay sensor kinase activity
HNE_RS09955	COG2204	response regulator
HNE_RS09960	COG3852	Histidine kinase
HNE_RS09965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HNE_RS09970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HNE_RS09970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HNE_RS09975	COG1024	Enoyl-CoA hydratase
HNE_RS09980	COG1058	Belongs to the CinA family
HNE_RS09980	COG1546	Belongs to the CinA family
HNE_RS10000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HNE_RS10035	COG0745	RESPONSE REGULATOR receiver
HNE_RS10045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HNE_RS10050	COG0581	inorganic phosphate transmembrane transporter activity
HNE_RS10055	COG0573	inorganic phosphate transmembrane transporter activity
HNE_RS10060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HNE_RS10065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HNE_RS10075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNE_RS10095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HNE_RS10115	COG3738	Protein conserved in bacteria
HNE_RS10125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HNE_RS10130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HNE_RS10135	COG1472	Belongs to the glycosyl hydrolase 3 family
HNE_RS10145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HNE_RS10150	COG0316	Belongs to the HesB IscA family
HNE_RS10155	COG0596	Alpha beta hydrolase
HNE_RS10165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HNE_RS10170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HNE_RS10190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HNE_RS10195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HNE_RS10200	COG4957	zinc ion binding
HNE_RS10205	COG0156	8-amino-7-oxononanoate synthase activity
HNE_RS10210	COG0235	Class ii aldolase
HNE_RS10215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HNE_RS10240	COG0544	peptidyl-prolyl cis-trans isomerase activity
HNE_RS10245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HNE_RS10245	COG0546	phosphoglycolate phosphatase activity
HNE_RS10295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HNE_RS10295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HNE_RS10310	COG0347	Belongs to the P(II) protein family
HNE_RS10315	COG0174	glutamine synthetase
HNE_RS10320	COG1408	metallophosphoesterase
HNE_RS10325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HNE_RS10330	COG0740	serine-type endopeptidase activity
HNE_RS10350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HNE_RS10360	COG1960	acyl-CoA dehydrogenase activity
HNE_RS10365	COG1960	acyl-CoA dehydrogenase activity
HNE_RS10385	COG5001	Diguanylate cyclase
HNE_RS10385	COG3300	MHYT domain
HNE_RS10410	COG2226	methyltransferase
HNE_RS10415	COG2853	Lipoprotein
HNE_RS10425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HNE_RS10465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HNE_RS10470	COG4774	siderophore transport
HNE_RS10475	COG3128	pkhd-type hydroxylase
HNE_RS10500	COG1984	allophanate hydrolase subunit 2
HNE_RS10510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HNE_RS10515	COG1914	H( )-stimulated, divalent metal cation uptake system
HNE_RS10525	COG4774	siderophore transport
HNE_RS10550	COG4948	Mandelate Racemase Muconate Lactonizing
HNE_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS10620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HNE_RS10625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HNE_RS10625	COG0758	DNA mediated transformation
HNE_RS10630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HNE_RS10635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HNE_RS10640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HNE_RS10645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HNE_RS10650	COG0194	GDP metabolic process
HNE_RS10655	COG1561	YicC-like family, N-terminal region
HNE_RS10660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HNE_RS10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HNE_RS10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HNE_RS10680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HNE_RS10685	COG0360	Binds together with S18 to 16S ribosomal RNA
HNE_RS10690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HNE_RS10695	COG0359	binds to the 23S rRNA
HNE_RS10705	COG1058	Belongs to the CinA family
HNE_RS10705	COG1546	Belongs to the CinA family
HNE_RS10710	COG1024	Enoyl-CoA hydratase
HNE_RS10715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HNE_RS10725	COG1492	cobalamin metabolic process
HNE_RS10760	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNE_RS10765	COG3119	arylsulfatase activity
HNE_RS10775	COG4771	TonB-dependent receptor
HNE_RS10785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNE_RS10790	COG3962	Belongs to the TPP enzyme family
HNE_RS10800	COG3718	enzyme involved in inositol metabolism
HNE_RS10805	COG0673	inositol 2-dehydrogenase activity
HNE_RS10825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNE_RS10830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNE_RS10840	COG1846	Transcriptional regulator
HNE_RS10870	COG2207	Transcriptional regulator
HNE_RS10895	COG0667	Aldo Keto reductase
HNE_RS10900	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS10940	COG0028	Belongs to the TPP enzyme family
HNE_RS10960	COG0179	Fumarylacetoacetate (FAA) hydrolase
HNE_RS10970	COG1012	belongs to the aldehyde dehydrogenase family
HNE_RS10975	COG0235	Class ii aldolase
HNE_RS10990	COG2814	Major facilitator Superfamily
HNE_RS11005	COG0667	Aldo Keto reductase
HNE_RS11010	COG2207	Transcriptional regulator
HNE_RS11030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HNE_RS11040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HNE_RS11040	COG1116	anion transmembrane transporter activity
HNE_RS11050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HNE_RS11055	COG2146	nitrite reductase [NAD(P)H] activity
HNE_RS11060	COG2116	formate transmembrane transporter activity
HNE_RS11065	COG0515	serine threonine protein kinase
HNE_RS11065	COG2815	serine threonine protein kinase
HNE_RS11095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HNE_RS11100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HNE_RS11105	COG0546	phosphoglycolate phosphatase activity
HNE_RS11110	COG2022	thiamine diphosphate biosynthetic process
HNE_RS11120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HNE_RS11125	COG0511	ligase activity, forming carbon-carbon bonds
HNE_RS11130	COG0439	Biotin carboxylase
HNE_RS11165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HNE_RS11170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HNE_RS11175	COG0248	Ppx GppA phosphatase
HNE_RS11180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HNE_RS11195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HNE_RS11200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HNE_RS11210	COG2130	NADP-dependent
HNE_RS11225	COG0105	UTP biosynthetic process
HNE_RS11230	COG2824	Alkylphosphonate utilization operon protein PhnA
HNE_RS11245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HNE_RS11250	COG0795	lipopolysaccharide-transporting ATPase activity
HNE_RS11260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HNE_RS11275	COG0557	exoribonuclease II activity
HNE_RS11285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HNE_RS11305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HNE_RS11325	COG0537	adenosine 5'-monophosphoramidase activity
HNE_RS11330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HNE_RS11340	COG0154	amidase activity
HNE_RS11360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HNE_RS11365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HNE_RS11375	COG0540	Belongs to the ATCase OTCase family
HNE_RS11385	COG0534	Mate efflux family protein
HNE_RS11400	COG2234	aminopeptidase activity
HNE_RS11425	COG0436	Aminotransferase
HNE_RS11435	COG3243	poly(R)-hydroxyalkanoic acid synthase
HNE_RS11445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HNE_RS11450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HNE_RS11460	COG1612	heme a metabolic process
HNE_RS11480	COG0427	acetyl-CoA hydrolase
HNE_RS11490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HNE_RS11515	COG0823	Involved in the tonB-independent uptake of proteins
HNE_RS11540	COG1012	belongs to the aldehyde dehydrogenase family
HNE_RS11545	COG1115	amino acid carrier protein
HNE_RS11560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HNE_RS11585	COG0784	Response regulator, receiver
HNE_RS11600	COG3273	potassium ion transport
HNE_RS11600	COG0471	metal ion transport
HNE_RS11645	COG0730	response to heat
HNE_RS11650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HNE_RS11655	COG2199	diguanylate cyclase activity
HNE_RS11685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HNE_RS11695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HNE_RS11710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HNE_RS11730	COG1611	Belongs to the LOG family
HNE_RS11735	COG0251	oxidation-reduction process
HNE_RS11740	COG2943	transferase activity, transferring hexosyl groups
HNE_RS11745	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HNE_RS11765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HNE_RS11770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNE_RS11785	COG1819	glycosyl
HNE_RS11795	COG2183	response to ionizing radiation
HNE_RS11800	COG1846	Transcriptional regulator
HNE_RS11805	COG1764	response to oxidative stress
HNE_RS11810	COG4771	TonB-dependent receptor
HNE_RS11815	COG2814	Major facilitator Superfamily
HNE_RS11835	COG0402	S-adenosylhomocysteine deaminase activity
HNE_RS11840	COG1228	amidohydrolase
HNE_RS11845	COG2986	histidine ammonia-lyase
HNE_RS11855	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HNE_RS11865	COG3713	MltA-interacting MipA family protein
HNE_RS11870	COG1309	transcriptional regulator
HNE_RS11885	COG1566	PFAM secretion protein HlyD family protein
HNE_RS11890	COG2814	Major facilitator Superfamily
HNE_RS11895	COG2264	protein methyltransferase activity
HNE_RS11900	COG4206	TonB-dependent receptor
HNE_RS11905	COG0584	glycerophosphoryl diester phosphodiesterase
HNE_RS11925	COG2267	carboxylic ester hydrolase activity
HNE_RS11940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNE_RS11955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNE_RS11960	COG0235	Class ii aldolase
HNE_RS11995	COG0446	pyridine nucleotide-disulphide oxidoreductase
HNE_RS12000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HNE_RS12020	COG2814	Major facilitator Superfamily
HNE_RS12035	COG3300	MHYT domain
HNE_RS12035	COG5001	Diguanylate cyclase
HNE_RS12060	COG1309	transcriptional regulator
HNE_RS12065	COG1960	acyl-CoA dehydrogenase activity
HNE_RS12070	COG1960	acyl-CoA dehydrogenase activity
HNE_RS12080	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS12085	COG2211	Major facilitator Superfamily
HNE_RS12105	COG3119	arylsulfatase activity
HNE_RS12135	COG3540	Alkaline phosphatase
HNE_RS12150	COG1737	Transcriptional regulator
HNE_RS12160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HNE_RS12175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HNE_RS12175	COG2755	lipolytic protein G-D-S-L family
HNE_RS12185	COG0587	DNA-directed DNA polymerase activity
HNE_RS12190	COG0753	catalase activity
HNE_RS12195	COG0562	UDP-galactopyranose mutase
HNE_RS12200	COG0776	regulation of translation
HNE_RS12205	COG2130	NADP-dependent
HNE_RS12255	COG0446	pyridine nucleotide-disulphide oxidoreductase
HNE_RS12265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HNE_RS12265	COG2010	Cytochrome c
HNE_RS12305	COG1921	L-seryl-tRNASec selenium transferase activity
HNE_RS12310	COG0709	Synthesizes selenophosphate from selenide and ATP
HNE_RS12315	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HNE_RS12350	COG1012	belongs to the aldehyde dehydrogenase family
HNE_RS12375	COG4771	TonB-dependent receptor
HNE_RS12380	COG0366	Alpha amylase catalytic
HNE_RS12390	COG1309	transcriptional regulator
HNE_RS12400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HNE_RS12435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HNE_RS12505	COG1475	DNA binding
HNE_RS12510	COG0514	ATP-dependent DNA helicase (RecQ)
HNE_RS12520	COG1396	sequence-specific DNA binding
HNE_RS12550	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HNE_RS12635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HNE_RS12645	COG3706	GGDEF domain
HNE_RS12650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HNE_RS12650	COG3743	rRNA binding
HNE_RS12655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HNE_RS12665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HNE_RS12680	COG0625	glutathione transferase activity
HNE_RS12700	COG0189	ligase activity
HNE_RS12705	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS12710	COG1946	Acyl-CoA thioesterase
HNE_RS12750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HNE_RS12780	COG1522	sequence-specific DNA binding
HNE_RS12805	COG2423	ornithine cyclodeaminase activity
HNE_RS12820	COG0531	amino acid
HNE_RS12825	COG0436	Aminotransferase
HNE_RS12860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HNE_RS12875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HNE_RS12880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HNE_RS12910	COG0316	Belongs to the HesB IscA family
HNE_RS12915	COG2151	metal-sulfur cluster biosynthetic enzyme
HNE_RS12920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HNE_RS12930	COG0396	ATPase activity
HNE_RS12940	COG0719	Fe-S assembly protein
HNE_RS12945	COG1104	cysteine desulfurase activity
HNE_RS12950	COG2945	thiolester hydrolase activity
HNE_RS12965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HNE_RS12980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HNE_RS12985	COG0739	heme binding
HNE_RS13005	COG0848	biopolymer transport protein
HNE_RS13010	COG0848	biopolymer transport protein
HNE_RS13015	COG0811	peptide transport
HNE_RS13020	COG0811	peptide transport
HNE_RS13035	COG0616	signal peptide processing
HNE_RS13040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNE_RS13045	COG0564	pseudouridine synthase activity
HNE_RS13050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HNE_RS13055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HNE_RS13065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HNE_RS13070	COG2211	Major facilitator Superfamily
HNE_RS13075	COG1960	acyl-CoA dehydrogenase activity
HNE_RS13085	COG1215	transferase activity, transferring glycosyl groups
HNE_RS13095	COG1596	polysaccharide export
HNE_RS13100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HNE_RS13155	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HNE_RS13170	COG4771	TonB-dependent receptor
HNE_RS13190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HNE_RS13215	COG2967	ApaG domain
HNE_RS13230	COG0531	amino acid
HNE_RS13265	COG2308	Evidence 4 Homologs of previously reported genes of
HNE_RS13270	COG0471	metal ion transport
HNE_RS13270	COG3273	potassium ion transport
HNE_RS13290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HNE_RS13315	COG2022	thiamine diphosphate biosynthetic process
HNE_RS13315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNE_RS13325	COG1840	ABC-type Fe3 transport system, periplasmic component
HNE_RS13330	COG4149	molybdate abc transporter
HNE_RS13350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNE_RS13365	COG0494	nUDIX hydrolase
HNE_RS13380	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HNE_RS13385	COG0183	Belongs to the thiolase family
HNE_RS13405	COG1054	Belongs to the UPF0176 family
HNE_RS13420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HNE_RS13430	COG0018	arginyl-trna synthetase
HNE_RS13455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HNE_RS13460	COG0509	glycine decarboxylation via glycine cleavage system
HNE_RS13465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HNE_RS13470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HNE_RS13475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HNE_RS13485	COG1228	amidohydrolase
HNE_RS13520	COG0730	response to heat
HNE_RS13525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HNE_RS13560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HNE_RS13565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HNE_RS13600	COG1024	Enoyl-CoA hydratase
HNE_RS13605	COG0861	Integral membrane protein TerC family
HNE_RS13610	COG2267	carboxylic ester hydrolase activity
HNE_RS13625	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS13630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HNE_RS13640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HNE_RS13645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HNE_RS13655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HNE_RS13675	COG0629	single-stranded DNA binding
HNE_RS13680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HNE_RS13695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HNE_RS13700	COG0037	tRNA processing
HNE_RS13710	COG0534	Mate efflux family protein
HNE_RS13730	COG0475	glutathione-regulated potassium exporter activity
HNE_RS13730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HNE_RS13735	COG0590	tRNA wobble adenosine to inosine editing
HNE_RS13745	COG0742	ribosomal rna small subunit methyltransferase
HNE_RS13760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HNE_RS13765	COG1051	belongs to the nudix hydrolase family
HNE_RS13785	COG2070	2-Nitropropane dioxygenase
HNE_RS13795	COG2133	pyrroloquinoline quinone binding
HNE_RS13810	COG0405	Gamma-glutamyltransferase
HNE_RS13815	COG1573	uracil-dna glycosylase
HNE_RS13835	COG1063	alcohol dehydrogenase
HNE_RS13850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HNE_RS13855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HNE_RS13860	COG0739	heme binding
HNE_RS13860	COG1196	nuclear chromosome segregation
HNE_RS13860	COG0741	lytic transglycosylase activity
HNE_RS13865	COG1012	belongs to the aldehyde dehydrogenase family
HNE_RS13870	COG1024	Enoyl-CoA hydratase
HNE_RS13895	COG1960	acyl-CoA dehydrogenase activity
HNE_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS13925	COG0625	glutathione transferase activity
HNE_RS13935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HNE_RS13955	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS13985	COG0203	ribosomal protein L17
HNE_RS13990	COG0202	RNA polymerase activity
HNE_RS13995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HNE_RS14000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HNE_RS14005	COG0563	adenylate kinase activity
HNE_RS14010	COG0201	protein transport
HNE_RS14015	COG0200	Binds to the 23S rRNA
HNE_RS14020	COG1841	ribosomal large subunit assembly
HNE_RS14025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HNE_RS14030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HNE_RS14035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HNE_RS14040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HNE_RS14045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HNE_RS14055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HNE_RS14060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HNE_RS14065	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HNE_RS14070	COG0255	Belongs to the universal ribosomal protein uL29 family
HNE_RS14075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HNE_RS14080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HNE_RS14085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HNE_RS14090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HNE_RS14095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HNE_RS14100	COG0089	rRNA binding
HNE_RS14105	COG0088	Forms part of the polypeptide exit tunnel
HNE_RS14110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HNE_RS14115	COG0051	transcription antitermination factor activity, RNA binding
HNE_RS14120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HNE_RS14125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HNE_RS14130	COG0049	tRNA binding
HNE_RS14135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HNE_RS14140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HNE_RS14145	COG0085	RNA polymerase activity
HNE_RS14150	COG0222	ribosome binding
HNE_RS14155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HNE_RS14170	COG0081	regulation of translation
HNE_RS14175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HNE_RS14225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNE_RS14240	COG0601	transmembrane transport
HNE_RS14245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HNE_RS14265	COG2321	neutral zinc metallopeptidase
HNE_RS14270	COG2873	o-acetylhomoserine
HNE_RS14285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HNE_RS14290	COG0358	DNA primase activity
HNE_RS14305	COG0505	Belongs to the CarA family
HNE_RS14360	COG3682	Transcriptional regulator
HNE_RS14375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HNE_RS14395	COG0308	aminopeptidase N
HNE_RS14415	COG1960	acyl-CoA dehydrogenase activity
HNE_RS14425	COG1960	acyl-CoA dehydrogenase activity
HNE_RS14440	COG1127	ABC transporter
HNE_RS14445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HNE_RS14450	COG4948	Mandelate Racemase Muconate Lactonizing
HNE_RS14460	COG0488	(ABC) transporter
HNE_RS14480	COG2363	Small membrane protein
HNE_RS14500	COG0733	neurotransmitter:sodium symporter activity
HNE_RS14505	COG0772	Belongs to the SEDS family
HNE_RS14510	COG0768	penicillin binding
HNE_RS14530	COG0210	DNA helicase
HNE_RS14550	COG1902	pentaerythritol trinitrate reductase activity
HNE_RS14550	COG0446	pyridine nucleotide-disulphide oxidoreductase
HNE_RS14585	COG0114	fumarate hydratase activity
HNE_RS14665	COG0322	excinuclease ABC activity
HNE_RS14680	COG0783	Belongs to the Dps family
HNE_RS14685	COG0657	acetylesterase activity
HNE_RS14700	COG0583	DNA-binding transcription factor activity
HNE_RS14720	COG0657	acetylesterase activity
HNE_RS14755	COG0492	ferredoxin-NADP+ reductase activity
HNE_RS14790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HNE_RS14800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HNE_RS14820	COG5001	Diguanylate cyclase
HNE_RS14825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNE_RS14825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HNE_RS14830	COG2957	Belongs to the agmatine deiminase family
HNE_RS14840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HNE_RS14845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNE_RS14850	COG4953	penicillin-binding protein 1C
HNE_RS14875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HNE_RS14905	COG5461	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD
HNE_RS14910	COG4964	Belongs to the GSP D family
HNE_RS14950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HNE_RS14960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HNE_RS14970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HNE_RS14975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HNE_RS14990	COG0768	penicillin binding
HNE_RS15000	COG0275	rRNA processing
HNE_RS15005	COG2001	Belongs to the MraZ family
HNE_RS15010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HNE_RS15040	COG0306	phosphate transporter
HNE_RS15055	COG0556	nucleotide-excision repair
HNE_RS15090	COG0596	Alpha beta hydrolase
HNE_RS15090	COG2945	thiolester hydrolase activity
HNE_RS15095	COG2814	Major facilitator Superfamily
HNE_RS15110	COG0842	Transport permease protein
HNE_RS15120	COG5002	protein histidine kinase activity
HNE_RS15130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNE_RS15140	COG3590	peptidase
HNE_RS15150	COG0386	Belongs to the glutathione peroxidase family
HNE_RS15155	COG0183	Belongs to the thiolase family
HNE_RS15175	COG1522	sequence-specific DNA binding
HNE_RS15190	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HNE_RS15200	COG1476	TRANSCRIPTIONal
HNE_RS15225	COG1960	acyl-CoA dehydrogenase activity
HNE_RS15230	COG1960	acyl-CoA dehydrogenase activity
HNE_RS15235	COG0415	Belongs to the DNA photolyase family
HNE_RS15260	COG0784	Response regulator, receiver
HNE_RS15295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HNE_RS15300	COG1846	Transcriptional regulator
HNE_RS15305	COG0745	RESPONSE REGULATOR receiver
HNE_RS15315	COG3153	acetyltransferase
HNE_RS15315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNE_RS15320	COG2154	pterin-4-alpha-carbinolamine dehydratase
HNE_RS15330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNE_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
HNE_RS15350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HNE_RS15355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HNE_RS15365	COG2902	Dehydrogenase
HNE_RS15370	COG0628	permease
HNE_RS15375	COG0433	COG0433 Predicted ATPase
HNE_RS15405	COG2814	Major facilitator Superfamily
HNE_RS15410	COG4067	protein conserved in archaea
HNE_RS15410	COG0189	ligase activity
HNE_RS15415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNE_RS15415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNE_RS15430	COG0604	alcohol dehydrogenase
HNE_RS15455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HNE_RS15465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HNE_RS15490	COG3339	Conserved Protein
HNE_RS15505	COG0183	Belongs to the thiolase family
HNE_RS15510	COG2030	dehydratase
HNE_RS15510	COG1012	belongs to the aldehyde dehydrogenase family
HNE_RS15540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HNE_RS15550	COG0745	RESPONSE REGULATOR receiver
HNE_RS15575	COG3191	aminopeptidase activity
HNE_RS15580	COG0405	Gamma-glutamyltransferase
HNE_RS15585	COG1435	thymidine kinase activity
HNE_RS15660	COG4152	abc transporter atp-binding protein
HNE_RS15675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HNE_RS15680	COG1040	competence protein
HNE_RS15695	COG0494	nUDIX hydrolase
HNE_RS15700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HNE_RS15705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HNE_RS15710	COG0653	protein targeting
HNE_RS15730	COG0126	phosphoglycerate kinase activity
HNE_RS15735	COG3588	fructose-bisphosphate aldolase
HNE_RS15745	COG3813	Protein conserved in bacteria
HNE_RS15755	COG0352	thiamine-phosphate diphosphorylase activity
HNE_RS15765	COG0483	inositol monophosphate 1-phosphatase activity
HNE_RS15790	COG1132	(ABC) transporter
HNE_RS15810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HNE_RS15815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HNE_RS15835	COG0215	cysteine-tRNA ligase activity
HNE_RS15840	COG0302	gtp cyclohydrolase
HNE_RS15860	COG1051	belongs to the nudix hydrolase family
HNE_RS15870	COG0793	Belongs to the peptidase S41A family
HNE_RS15915	COG0039	L-malate dehydrogenase activity
HNE_RS15920	COG0670	Belongs to the BI1 family
HNE_RS15940	COG3932	Exopolysaccharide synthesis, ExoD
HNE_RS15950	COG1960	acyl-CoA dehydrogenase activity
HNE_RS15960	COG0181	hydroxymethylbilane synthase activity
HNE_RS15990	COG0384	phenazine biosynthesis protein PhzF
HNE_RS15995	COG0351	phosphomethylpyrimidine kinase
HNE_RS16000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HNE_RS16005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HNE_RS16015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HNE_RS16025	COG0519	Catalyzes the synthesis of GMP from XMP
HNE_RS16025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HNE_RS16030	COG1132	(ABC) transporter
HNE_RS16090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HNE_RS16095	COG1872	DUF167
HNE_RS16140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HNE_RS16150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HNE_RS16165	COG0756	dUTP diphosphatase activity
HNE_RS16170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HNE_RS16185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HNE_RS16195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HNE_RS16200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNE_RS16235	COG1960	acyl-CoA dehydrogenase activity
HNE_RS16240	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HNE_RS16245	COG1024	Enoyl-CoA hydratase
HNE_RS16250	COG3932	Exopolysaccharide synthesis, ExoD
HNE_RS16260	COG2070	2-Nitropropane dioxygenase
HNE_RS16265	COG0339	signal peptide processing
HNE_RS16270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HNE_RS16275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HNE_RS16285	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HNE_RS16290	COG1842	Phage shock protein A
HNE_RS16310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNE_RS16310	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HNE_RS16330	COG2983	Belongs to the UPF0260 family
HNE_RS16360	COG4974	Belongs to the 'phage' integrase family
HNE_RS16365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HNE_RS16370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HNE_RS16380	COG3655	Transcriptional regulator
HNE_RS16400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HNE_RS16410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HNE_RS16425	COG0443	Heat shock 70 kDa protein
HNE_RS16460	COG1595	DNA-templated transcription, initiation
HNE_RS16470	COG2885	chlorophyll binding
HNE_RS16475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HNE_RS16495	COG1393	Belongs to the ArsC family
HNE_RS16510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HNE_RS16525	COG1692	metallophosphoesterase
HNE_RS16545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HNE_RS16560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HNE_RS16575	COG0596	Alpha beta hydrolase
HNE_RS16580	COG3750	Belongs to the UPF0335 family
HNE_RS16610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HNE_RS16630	COG1846	Transcriptional regulator
HNE_RS16645	COG0501	Belongs to the peptidase M48B family
HNE_RS16650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HNE_RS16650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HNE_RS16670	COG0138	bifunctional purine biosynthesis protein purh
HNE_RS16680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HNE_RS16685	COG1024	Enoyl-CoA hydratase
HNE_RS16690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HNE_RS16750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HNE_RS16760	COG2884	Cell division ATP-binding protein ftsE
HNE_RS16790	COG0463	Glycosyl transferase, family 2
HNE_RS16795	COG1999	signal sequence binding
HNE_RS16805	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HNE_RS16810	COG0287	Prephenate dehydrogenase
HNE_RS16825	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HNE_RS16840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNE_RS16905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HNE_RS16930	COG0596	Alpha beta hydrolase
HNE_RS16940	COG0789	Transcriptional regulator
HNE_RS16955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HNE_RS16960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HNE_RS16965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HNE_RS16985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HNE_RS16990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HNE_RS16995	COG3811	Belongs to the UPF0386 family
HNE_RS17010	COG0572	uridine kinase
HNE_RS17015	COG1185	polyribonucleotide nucleotidyltransferase activity
HNE_RS17020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HNE_RS17070	COG0372	Belongs to the citrate synthase family
HNE_RS17075	COG0372	Belongs to the citrate synthase family
HNE_RS17105	COG2096	Adenosyltransferase
HNE_RS17120	COG0019	diaminopimelate decarboxylase activity
HNE_RS17135	COG0165	Argininosuccinate lyase
HNE_RS17140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HNE_RS17155	COG1250	3-hydroxyacyl-CoA dehydrogenase
HNE_RS17165	COG2086	electron transfer activity
HNE_RS17170	COG0285	dihydrofolate synthase activity
HNE_RS17175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HNE_RS17190	COG0133	tryptophan synthase activity
HNE_RS17195	COG0135	phosphoribosylanthranilate isomerase activity
HNE_RS17205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNE_RS17215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HNE_RS17250	COG0167	dihydroorotate dehydrogenase activity
HNE_RS17265	COG0137	argininosuccinate synthase activity
HNE_RS17290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNE_RS17295	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HNE_RS17300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HNE_RS17310	COG0564	pseudouridine synthase activity
HNE_RS17330	COG3706	GGDEF domain
HNE_RS17335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HNE_RS17340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HNE_RS17350	COG1131	(ABC) transporter
HNE_RS17380	COG4133	protoheme IX ABC transporter activity
HNE_RS17385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HNE_RS17390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HNE_RS17395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HNE_RS17405	COG2816	NAD+ diphosphatase activity
HNE_RS17425	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HNE_RS17430	COG0552	protein localization to endoplasmic reticulum
HNE_RS17435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNE_RS17445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HNE_RS17455	COG2030	dehydratase
HNE_RS17465	COG1393	Belongs to the ArsC family
HNE_RS17470	COG2301	Belongs to the HpcH HpaI aldolase family
HNE_RS17485	COG2962	Rard protein
HNE_RS17495	COG0457	Tetratricopeptide repeat
HNE_RS17500	COG0667	Aldo Keto reductase
HNE_RS17505	COG1674	ftsk spoiiie
HNE_RS17510	COG0004	ammonium transporteR
HNE_RS17515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNE_RS17525	COG2835	tetraacyldisaccharide 4'-kinase activity
HNE_RS17530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HNE_RS17535	COG3118	belongs to the thioredoxin family
HNE_RS17540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HNE_RS17550	COG0745	RESPONSE REGULATOR receiver
HNE_RS17565	COG0352	thiamine-phosphate diphosphorylase activity
HNE_RS17585	COG0495	leucyl-tRNA aminoacylation
HNE_RS17610	COG0357	Ribosomal RNA small subunit methyltransferase G
HNE_RS17615	COG0445	tRNA wobble uridine modification
HNE_RS17620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HNE_RS17625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HNE_RS17635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HNE_RS17640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HNE_RS17690	COG0037	tRNA processing
HNE_RS17730	COG1214	PFAM Peptidase M22, glycoprotease
HNE_RS17735	COG3264	Mechanosensitive ion channel
HNE_RS17735	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HNE_RS17760	COG0741	lytic transglycosylase activity
HNE_RS17760	COG0739	heme binding
HNE_RS17760	COG1196	nuclear chromosome segregation
HNE_RS17775	COG2205	protein histidine kinase activity
HNE_RS17780	COG2942	2-epimerase
HNE_RS17805	COG1309	transcriptional regulator
HNE_RS17820	COG1686	Belongs to the peptidase S11 family
HNE_RS17825	COG3346	SURF1 family
HNE_RS17835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HNE_RS17845	COG0688	phosphatidylethanolamine metabolic process
HNE_RS17895	COG5001	Diguanylate cyclase
HNE_RS17935	COG0515	serine threonine protein kinase
HNE_RS17935	COG2815	serine threonine protein kinase
HNE_RS17975	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HNE_RS17985	COG0052	Belongs to the universal ribosomal protein uS2 family
HNE_RS17990	COG1396	sequence-specific DNA binding
HNE_RS18015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HNE_RS18015	COG3743	rRNA binding
HNE_RS18025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HNE_RS18030	COG1309	transcriptional regulator
HNE_RS18050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HNE_RS18075	COG2885	chlorophyll binding
HNE_RS18075	COG3047	cAMP biosynthetic process
HNE_RS18100	COG0318	PFAM AMP-dependent synthetase and ligase
HNE_RS18105	COG2273	Hydrolase Family 16
HNE_RS18135	COG3743	rRNA binding
HNE_RS18135	COG0052	Belongs to the universal ribosomal protein uS2 family
HNE_RS18140	COG2202	Pas domain
HNE_RS18140	COG2205	protein histidine kinase activity
HNE_RS18170	COG0784	Response regulator, receiver
HNE_RS18170	COG4191	Histidine kinase
HNE_RS18215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HNE_RS18225	COG1404	Belongs to the peptidase S8 family