locus-tag	class	description
GH723_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GH723_RS00010	COG0592	DNA-directed DNA polymerase activity
GH723_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GH723_RS00025	COG0187	DNA topoisomerase II activity
GH723_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GH723_RS00055	COG1191	sigma factor activity
GH723_RS00085	COG0714	Associated with various cellular activities
GH723_RS00130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GH723_RS00140	COG1121	(ABC) transporter
GH723_RS00160	COG2124	cytochrome p450
GH723_RS00165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH723_RS00170	COG1321	iron dependent repressor
GH723_RS00185	COG4251	negative regulation of phosphorylation
GH723_RS00185	COG3706	GGDEF domain
GH723_RS00185	COG2203	Gaf domain
GH723_RS00185	COG5001	Diguanylate cyclase
GH723_RS00195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GH723_RS00205	COG1283	sodium-dependent phosphate transmembrane transporter activity
GH723_RS00235	COG0667	Aldo Keto reductase
GH723_RS00240	COG1309	transcriptional regulator
GH723_RS00245	COG4585	Histidine kinase
GH723_RS00250	COG0784	Response regulator, receiver
GH723_RS00255	COG4251	negative regulation of phosphorylation
GH723_RS00275	COG2608	mercury ion transmembrane transporter activity
GH723_RS00290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GH723_RS00295	COG3800	Transcriptional regulator
GH723_RS00295	COG1396	sequence-specific DNA binding
GH723_RS00325	COG2151	metal-sulfur cluster biosynthetic enzyme
GH723_RS00355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH723_RS00370	COG2186	Transcriptional regulator
GH723_RS00375	COG1960	acyl-CoA dehydrogenase activity
GH723_RS00415	COG1024	Enoyl-CoA hydratase
GH723_RS00420	COG0183	Belongs to the thiolase family
GH723_RS00425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH723_RS00430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS00445	COG1024	Enoyl-CoA hydratase
GH723_RS00490	COG1047	Peptidyl-prolyl cis-trans
GH723_RS00500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GH723_RS00510	COG1174	glycine betaine transport
GH723_RS00515	COG1174	glycine betaine transport
GH723_RS00525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GH723_RS00530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GH723_RS00540	COG1595	DNA-templated transcription, initiation
GH723_RS00550	COG0259	pyridoxamine-phosphate oxidase activity
GH723_RS00595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GH723_RS00600	COG0756	dUTP diphosphatase activity
GH723_RS00605	COG2172	sigma factor antagonist activity
GH723_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS00665	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GH723_RS00680	COG3273	potassium ion transport
GH723_RS00680	COG0471	metal ion transport
GH723_RS00710	COG0577	efflux transmembrane transporter activity
GH723_RS00710	COG1136	(ABC) transporter
GH723_RS00720	COG0657	acetylesterase activity
GH723_RS00735	COG1473	amidohydrolase
GH723_RS00755	COG4152	abc transporter atp-binding protein
GH723_RS00760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GH723_RS00765	COG2364	Membrane
GH723_RS00830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH723_RS00845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH723_RS00860	COG0406	alpha-ribazole phosphatase activity
GH723_RS00880	COG1796	DNA polymerase
GH723_RS00880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GH723_RS00895	COG0438	transferase activity, transferring glycosyl groups
GH723_RS00905	COG2814	Major facilitator Superfamily
GH723_RS00910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GH723_RS00915	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GH723_RS00930	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS00935	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GH723_RS00940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GH723_RS00945	COG0181	hydroxymethylbilane synthase activity
GH723_RS00955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH723_RS00960	COG0113	porphobilinogen synthase activity
GH723_RS00965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GH723_RS00985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH723_RS01010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS01015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS01020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS01025	COG0649	NAD binding
GH723_RS01035	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH723_RS01040	COG1034	ATP synthesis coupled electron transport
GH723_RS01045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH723_RS01050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS01055	COG0839	Belongs to the complex I subunit 6 family
GH723_RS01060	COG0713	ATP synthesis coupled electron transport
GH723_RS01075	COG1007	ATP synthesis coupled electron transport
GH723_RS01085	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS01090	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS01100	COG0649	NAD binding
GH723_RS01105	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH723_RS01110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS01120	COG0713	ATP synthesis coupled electron transport
GH723_RS01125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH723_RS01135	COG1007	ATP synthesis coupled electron transport
GH723_RS01155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH723_RS01185	COG1247	-acetyltransferase
GH723_RS01210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH723_RS01215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GH723_RS01240	COG0250	Participates in transcription elongation, termination and antitermination
GH723_RS01245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GH723_RS01250	COG0081	regulation of translation
GH723_RS01255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GH723_RS01260	COG0222	ribosome binding
GH723_RS01265	COG0085	RNA polymerase activity
GH723_RS01270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GH723_RS01275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GH723_RS01285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH723_RS01290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH723_RS01295	COG0051	transcription antitermination factor activity, RNA binding
GH723_RS01320	COG0572	uridine kinase
GH723_RS01355	COG1294	oxidase, subunit
GH723_RS01360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GH723_RS01365	COG0088	Forms part of the polypeptide exit tunnel
GH723_RS01370	COG0089	rRNA binding
GH723_RS01375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GH723_RS01380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GH723_RS01385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GH723_RS01390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GH723_RS01395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GH723_RS01400	COG0255	Belongs to the universal ribosomal protein uL29 family
GH723_RS01405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GH723_RS01410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GH723_RS01415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GH723_RS01420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GH723_RS01430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GH723_RS01435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GH723_RS01440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GH723_RS01445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GH723_RS01450	COG1841	ribosomal large subunit assembly
GH723_RS01455	COG0200	Binds to the 23S rRNA
GH723_RS01465	COG0563	adenylate kinase activity
GH723_RS01470	COG0024	Methionine aminopeptidase
GH723_RS01475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GH723_RS01480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GH723_RS01495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GH723_RS01500	COG0202	RNA polymerase activity
GH723_RS01505	COG0203	ribosomal protein L17
GH723_RS01510	COG0101	tRNA pseudouridine synthase activity
GH723_RS01515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GH723_RS01520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GH723_RS01525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH723_RS01530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GH723_RS01535	COG0736	holo-[acyl-carrier-protein] synthase activity
GH723_RS01545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH723_RS01545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GH723_RS01550	COG0517	IMP dehydrogenase activity
GH723_RS01550	COG0516	GMP reductase activity
GH723_RS01555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GH723_RS01565	COG3191	aminopeptidase activity
GH723_RS01570	COG0802	atpase or kinase
GH723_RS01575	COG1214	PFAM Peptidase M22, glycoprotease
GH723_RS01575	COG0456	acetyltransferase
GH723_RS01585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GH723_RS01590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GH723_RS01595	COG0459	protein refolding
GH723_RS01610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH723_RS01635	COG0516	GMP reductase activity
GH723_RS01650	COG0516	GMP reductase activity
GH723_RS01650	COG0517	IMP dehydrogenase activity
GH723_RS01655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH723_RS01655	COG0519	Catalyzes the synthesis of GMP from XMP
GH723_RS01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS01690	COG0210	DNA helicase
GH723_RS01715	COG0426	domain, Protein
GH723_RS01715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GH723_RS01725	COG0045	succinate-CoA ligase (ADP-forming) activity
GH723_RS01730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GH723_RS01750	COG0138	bifunctional purine biosynthesis protein purh
GH723_RS01760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GH723_RS01775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GH723_RS01780	COG0563	adenylate kinase activity
GH723_RS01785	COG0538	isocitrate dehydrogenase activity
GH723_RS01795	COG1132	(ABC) transporter
GH723_RS01800	COG1132	(ABC) transporter
GH723_RS01805	COG1309	transcriptional regulator
GH723_RS01810	COG0477	Major facilitator Superfamily
GH723_RS01815	COG0039	L-malate dehydrogenase activity
GH723_RS01820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH723_RS01840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GH723_RS01855	COG1053	succinate dehydrogenase
GH723_RS01870	COG3250	beta-galactosidase activity
GH723_RS01900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH723_RS01915	COG1940	carbohydrate kinase activity
GH723_RS01920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GH723_RS01925	COG0406	alpha-ribazole phosphatase activity
GH723_RS01925	COG0494	nUDIX hydrolase
GH723_RS01930	COG0501	Belongs to the peptidase M48B family
GH723_RS01935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GH723_RS01940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GH723_RS01945	COG0573	inorganic phosphate transmembrane transporter activity
GH723_RS01955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GH723_RS01965	COG0704	Plays a role in the regulation of phosphate uptake
GH723_RS01970	COG5002	protein histidine kinase activity
GH723_RS01975	COG0745	RESPONSE REGULATOR receiver
GH723_RS01980	COG2814	Major facilitator Superfamily
GH723_RS01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH723_RS02000	COG0314	molybdopterin synthase activity
GH723_RS02010	COG1077	Cell shape determining protein MreB Mrl
GH723_RS02015	COG1268	BioY protein
GH723_RS02020	COG1024	Enoyl-CoA hydratase
GH723_RS02040	COG3480	Lon protease (S16) C-terminal proteolytic domain
GH723_RS02050	COG1615	UPF0182 protein
GH723_RS02065	COG0582	viral genome integration into host DNA
GH723_RS02070	COG1846	Transcriptional regulator
GH723_RS02100	COG2030	dehydratase
GH723_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS02115	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02140	COG2409	Drug exporters of the RND superfamily
GH723_RS02150	COG1309	transcriptional regulator
GH723_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS02160	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02175	COG2072	flavoprotein involved in K transport
GH723_RS02180	COG1024	Enoyl-CoA hydratase
GH723_RS02210	COG1012	belongs to the aldehyde dehydrogenase family
GH723_RS02220	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02235	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02240	COG2070	2-Nitropropane dioxygenase
GH723_RS02270	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS02275	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS02295	COG2409	Drug exporters of the RND superfamily
GH723_RS02305	COG1309	transcriptional regulator
GH723_RS02310	COG0596	Alpha beta hydrolase
GH723_RS02330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GH723_RS02335	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GH723_RS02380	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02405	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS02425	COG2072	flavoprotein involved in K transport
GH723_RS02430	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH723_RS02495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH723_RS02500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH723_RS02530	COG1024	Enoyl-CoA hydratase
GH723_RS02540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH723_RS02555	COG1960	acyl-CoA dehydrogenase activity
GH723_RS02565	COG1024	Enoyl-CoA hydratase
GH723_RS02580	COG2070	2-Nitropropane dioxygenase
GH723_RS02590	COG3328	transposase activity
GH723_RS02595	COG2409	Drug exporters of the RND superfamily
GH723_RS02610	COG1309	transcriptional regulator
GH723_RS02615	COG0477	Major facilitator Superfamily
GH723_RS02635	COG0736	holo-[acyl-carrier-protein] synthase activity
GH723_RS02665	COG0582	viral genome integration into host DNA
GH723_RS02685	COG1475	DNA binding
GH723_RS02730	COG0697	spore germination
GH723_RS02735	COG2217	Heavy metal translocating P-type atpase
GH723_RS02745	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GH723_RS02750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GH723_RS02765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH723_RS02775	COG1063	alcohol dehydrogenase
GH723_RS02800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH723_RS02835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH723_RS02840	COG4106	trans-aconitate 2-methyltransferase activity
GH723_RS02855	COG0494	nUDIX hydrolase
GH723_RS02870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH723_RS02880	COG1937	Protein conserved in bacteria
GH723_RS02910	COG3573	Dehydrogenase
GH723_RS02925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH723_RS02930	COG0713	ATP synthesis coupled electron transport
GH723_RS02940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH723_RS02945	COG0649	NAD binding
GH723_RS02950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS02960	COG2132	Multicopper oxidase
GH723_RS02975	COG3328	transposase activity
GH723_RS02990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH723_RS03025	COG1615	UPF0182 protein
GH723_RS03050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GH723_RS03055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GH723_RS03100	COG3764	Sortase (surface protein transpeptidase)
GH723_RS03120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH723_RS03160	COG1611	Belongs to the LOG family
GH723_RS03180	COG1131	(ABC) transporter
GH723_RS03185	COG2217	Heavy metal translocating P-type atpase
GH723_RS03220	COG2217	Heavy metal translocating P-type atpase
GH723_RS03240	COG3177	Filamentation induced by cAMP protein fic
GH723_RS03265	COG2267	carboxylic ester hydrolase activity
GH723_RS03280	COG0488	(ABC) transporter
GH723_RS03305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GH723_RS03335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GH723_RS03345	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GH723_RS03355	COG3848	Pyruvate phosphate dikinase
GH723_RS03355	COG0574	Belongs to the PEP-utilizing enzyme family
GH723_RS03360	COG3467	pyridoxamine 5'-phosphate
GH723_RS03370	COG0586	Pfam SNARE associated Golgi protein
GH723_RS03380	COG0725	ABC transporter, periplasmic molybdate-binding protein
GH723_RS03410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GH723_RS03420	COG0640	Transcriptional regulator
GH723_RS03445	COG0659	secondary active sulfate transmembrane transporter activity
GH723_RS03450	COG2818	Glycosylase
GH723_RS03465	COG0586	Pfam SNARE associated Golgi protein
GH723_RS03470	COG0277	FAD linked oxidase domain protein
GH723_RS03480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GH723_RS03485	COG2354	Protein conserved in bacteria
GH723_RS03500	COG0640	Transcriptional regulator
GH723_RS03525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GH723_RS03535	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GH723_RS03550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH723_RS03555	COG0640	Transcriptional regulator
GH723_RS03565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH723_RS03570	COG0406	alpha-ribazole phosphatase activity
GH723_RS03590	COG2409	Drug exporters of the RND superfamily
GH723_RS03595	COG2814	Major facilitator Superfamily
GH723_RS03605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GH723_RS03640	COG1794	racemase activity, acting on amino acids and derivatives
GH723_RS03650	COG3384	dioxygenase
GH723_RS03670	COG2208	phosphoserine phosphatase activity
GH723_RS03670	COG2770	Histidine kinase
GH723_RS03685	COG2375	cellular response to nickel ion
GH723_RS03695	COG1968	undecaprenyl-diphosphatase activity
GH723_RS03705	COG1595	DNA-templated transcription, initiation
GH723_RS03710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH723_RS03715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH723_RS03730	COG0405	Gamma-glutamyltransferase
GH723_RS03735	COG1595	DNA-templated transcription, initiation
GH723_RS03750	COG0671	phosphoesterase, PA-phosphatase related
GH723_RS03755	COG1960	acyl-CoA dehydrogenase activity
GH723_RS03760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GH723_RS03775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH723_RS03780	COG1960	acyl-CoA dehydrogenase activity
GH723_RS03785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH723_RS03790	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH723_RS03805	COG1522	sequence-specific DNA binding
GH723_RS03810	COG2301	Belongs to the HpcH HpaI aldolase family
GH723_RS03830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH723_RS03830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GH723_RS03840	COG0753	catalase activity
GH723_RS03845	COG0596	Alpha beta hydrolase
GH723_RS03850	COG2197	response regulator
GH723_RS03870	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GH723_RS03885	COG1328	CTP reductase activity
GH723_RS03890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GH723_RS03900	COG2378	regulation of single-species biofilm formation
GH723_RS03925	COG2226	methyltransferase
GH723_RS03960	COG0803	Belongs to the bacterial solute-binding protein 9 family
GH723_RS03980	COG0596	Alpha beta hydrolase
GH723_RS03995	COG2124	cytochrome p450
GH723_RS04010	COG0456	acetyltransferase
GH723_RS04045	COG0653	protein targeting
GH723_RS04055	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
GH723_RS04070	COG0477	Major facilitator Superfamily
GH723_RS04100	COG2337	Toxic component of a toxin-antitoxin (TA) module
GH723_RS04105	COG1397	ADP-ribosylglycohydrolase
GH723_RS04210	COG1201	RNA secondary structure unwinding
GH723_RS04280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH723_RS04295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH723_RS04330	COG1136	(ABC) transporter
GH723_RS04330	COG0577	efflux transmembrane transporter activity
GH723_RS04335	COG4585	Histidine kinase
GH723_RS04340	COG2197	response regulator
GH723_RS04385	COG2337	Toxic component of a toxin-antitoxin (TA) module
GH723_RS04395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH723_RS04415	COG4604	ABC transporter, ATP-binding protein
GH723_RS04420	COG4605	iron ion homeostasis
GH723_RS04425	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH723_RS04430	COG4607	ABC-type enterochelin transport system periplasmic component
GH723_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS04470	COG3654	unkown
GH723_RS04480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS04505	COG2267	carboxylic ester hydrolase activity
GH723_RS04540	COG2954	triphosphatase activity
GH723_RS04545	COG2072	flavoprotein involved in K transport
GH723_RS04585	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GH723_RS04610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH723_RS04635	COG0640	Transcriptional regulator
GH723_RS04640	COG2814	Major facilitator Superfamily
GH723_RS04650	COG0628	permease
GH723_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS04690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH723_RS04710	COG1309	transcriptional regulator
GH723_RS04725	COG1554	hydrolase, family 65, central catalytic
GH723_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS04750	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS04785	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GH723_RS04820	COG5002	protein histidine kinase activity
GH723_RS04850	COG2409	Drug exporters of the RND superfamily
GH723_RS04860	COG0765	amino acid transport
GH723_RS04865	COG0765	amino acid transport
GH723_RS04870	COG1126	abc transporter atp-binding protein
GH723_RS04890	COG2723	6-phospho-beta-galactosidase activity
GH723_RS04920	COG1960	acyl-CoA dehydrogenase activity
GH723_RS04945	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS04960	COG1253	flavin adenine dinucleotide binding
GH723_RS04975	COG0640	Transcriptional regulator
GH723_RS04985	COG0740	serine-type endopeptidase activity
GH723_RS05000	COG0668	transmembrane transport
GH723_RS05005	COG0525	valine-tRNA ligase activity
GH723_RS05010	COG2199	diguanylate cyclase activity
GH723_RS05015	COG0215	cysteine-tRNA ligase activity
GH723_RS05020	COG1946	Acyl-CoA thioesterase
GH723_RS05035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH723_RS05055	COG0438	transferase activity, transferring glycosyl groups
GH723_RS05065	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GH723_RS05085	COG1126	abc transporter atp-binding protein
GH723_RS05095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH723_RS05110	COG1138	Cytochrome C-type biogenesis protein
GH723_RS05115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH723_RS05130	COG0406	alpha-ribazole phosphatase activity
GH723_RS05150	COG1104	cysteine desulfurase activity
GH723_RS05160	COG2151	metal-sulfur cluster biosynthetic enzyme
GH723_RS05160	COG0489	protein tyrosine kinase activity
GH723_RS05175	COG0003	Pfam Anion-transporting ATPase
GH723_RS05210	COG1597	lipid kinase activity
GH723_RS05215	COG2086	electron transfer activity
GH723_RS05220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GH723_RS05260	COG1316	TRANSCRIPTIONal
GH723_RS05270	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GH723_RS05275	COG3706	GGDEF domain
GH723_RS05275	COG2203	Gaf domain
GH723_RS05275	COG5001	Diguanylate cyclase
GH723_RS05275	COG4251	negative regulation of phosphorylation
GH723_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS05290	COG0456	acetyltransferase
GH723_RS05290	COG0454	-acetyltransferase
GH723_RS05300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH723_RS05300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH723_RS05315	COG1960	acyl-CoA dehydrogenase activity
GH723_RS05320	COG0242	peptide deformylase activity
GH723_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS05355	COG1253	flavin adenine dinucleotide binding
GH723_RS05365	COG0018	arginyl-trna synthetase
GH723_RS05375	COG0460	homoserine dehydrogenase
GH723_RS05405	COG0254	rRNA binding
GH723_RS05415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GH723_RS05420	COG2890	protein-(glutamine-N5) methyltransferase activity
GH723_RS05435	COG0698	ribose 5-phosphate isomerase
GH723_RS05440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GH723_RS05445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH723_RS05465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH723_RS05470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GH723_RS05475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH723_RS05480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GH723_RS05485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GH723_RS05490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GH723_RS05495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GH723_RS05500	COG2326	polyphosphate kinase activity
GH723_RS05515	COG0535	radical SAM domain protein
GH723_RS05550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GH723_RS05590	COG2226	methyltransferase
GH723_RS05605	COG0482	sulfurtransferase activity
GH723_RS05620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GH723_RS05630	COG0515	serine threonine protein kinase
GH723_RS05640	COG0745	RESPONSE REGULATOR receiver
GH723_RS05645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH723_RS05650	COG1256	bacterial-type flagellum assembly
GH723_RS05650	COG4786	Flagellar basal body rod
GH723_RS05660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH723_RS05665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GH723_RS05680	COG1815	bacterial-type flagellum-dependent cell motility
GH723_RS05690	COG1677	Flagellar hook-basal body complex protein FliE
GH723_RS05700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH723_RS05705	COG1317	bacterial-type flagellum organization
GH723_RS05710	COG1157	protein secretion by the type III secretion system
GH723_RS05720	COG0791	NLP P60 protein
GH723_RS05730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GH723_RS05745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GH723_RS05760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH723_RS05765	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH723_RS05765	COG1776	CheC inhibitor of MCP methylation
GH723_RS05775	COG1338	Plays a role in the flagellum-specific transport system
GH723_RS05780	COG1987	bacterial-type flagellum assembly
GH723_RS05785	COG1684	flagellar biosynthetic protein fliR
GH723_RS05790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH723_RS05795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH723_RS05810	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GH723_RS05820	COG1191	sigma factor activity
GH723_RS05850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH723_RS05855	COG0154	amidase activity
GH723_RS05860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH723_RS05880	COG1131	(ABC) transporter
GH723_RS05890	COG1131	(ABC) transporter
GH723_RS05895	COG0129	dihydroxy-acid dehydratase activity
GH723_RS05910	COG0440	acetolactate synthase activity
GH723_RS05915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GH723_RS05930	COG0436	Aminotransferase
GH723_RS05945	COG0066	3-isopropylmalate dehydratase activity
GH723_RS05950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GH723_RS05960	COG1215	transferase activity, transferring glycosyl groups
GH723_RS05970	COG0745	RESPONSE REGULATOR receiver
GH723_RS05975	COG5002	protein histidine kinase activity
GH723_RS05980	COG2267	carboxylic ester hydrolase activity
GH723_RS05985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH723_RS05995	COG0473	3-isopropylmalate dehydrogenase activity
GH723_RS06005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH723_RS06015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH723_RS06055	COG0210	DNA helicase
GH723_RS06090	COG3328	transposase activity
GH723_RS06095	COG3590	peptidase
GH723_RS06115	COG1132	(ABC) transporter
GH723_RS06145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GH723_RS06165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GH723_RS06200	COG1175	transmembrane transport
GH723_RS06205	COG3842	ATPase activity
GH723_RS06225	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GH723_RS06250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GH723_RS06260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GH723_RS06270	COG0383	alpha-mannosidase activity
GH723_RS06280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GH723_RS06300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH723_RS06305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GH723_RS06310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GH723_RS06320	COG0643	Histidine kinase
GH723_RS06320	COG0784	Response regulator, receiver
GH723_RS06320	COG2198	Histidine kinase
GH723_RS06340	COG0745	RESPONSE REGULATOR receiver
GH723_RS06345	COG2201	protein-glutamate methylesterase activity
GH723_RS06360	COG3973	AAA domain
GH723_RS06375	COG0587	DNA-directed DNA polymerase activity
GH723_RS06400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GH723_RS06415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GH723_RS06425	COG3394	polysaccharide catabolic process
GH723_RS06430	COG1525	nuclease
GH723_RS06435	COG0183	Belongs to the thiolase family
GH723_RS06495	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS06500	COG1960	acyl-CoA dehydrogenase activity
GH723_RS06510	COG2070	2-Nitropropane dioxygenase
GH723_RS06515	COG0644	oxidoreductase
GH723_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS06530	COG2030	dehydratase
GH723_RS06550	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GH723_RS06560	COG1218	3'(2'),5'-bisphosphate nucleotidase
GH723_RS06565	COG0488	(ABC) transporter
GH723_RS06580	COG0567	Dehydrogenase, E1 component
GH723_RS06580	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH723_RS06585	COG0708	Exodeoxyribonuclease III
GH723_RS06595	COG0803	Belongs to the bacterial solute-binding protein 9 family
GH723_RS06600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GH723_RS06615	COG3830	Belongs to the UPF0237 family
GH723_RS06620	COG0242	peptide deformylase activity
GH723_RS06640	COG4555	ABC transporter
GH723_RS06645	COG0693	protein deglycase activity
GH723_RS06650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS06670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH723_RS06675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GH723_RS06685	COG1454	alcohol dehydrogenase
GH723_RS06750	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GH723_RS06760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GH723_RS06765	COG1461	Dihydroxyacetone kinase
GH723_RS06770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GH723_RS06785	COG0742	ribosomal rna small subunit methyltransferase
GH723_RS06790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GH723_RS06800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GH723_RS06805	COG0416	fatty acid biosynthetic process
GH723_RS06810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH723_RS06815	COG0571	ribonuclease III activity
GH723_RS06820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH723_RS06830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH723_RS06835	COG0552	protein localization to endoplasmic reticulum
GH723_RS06850	COG0228	four-way junction DNA binding
GH723_RS06855	COG1837	Belongs to the UPF0109 family
GH723_RS06860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GH723_RS06865	COG0336	Belongs to the RNA methyltransferase TrmD family
GH723_RS06870	COG0335	large ribosomal subunit rRNA binding
GH723_RS06875	COG0792	nuclease activity
GH723_RS06880	COG0406	alpha-ribazole phosphatase activity
GH723_RS06900	COG0758	DNA mediated transformation
GH723_RS06905	COG4974	Belongs to the 'phage' integrase family
GH723_RS06910	COG1191	sigma factor activity
GH723_RS06925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GH723_RS06930	COG0528	UMP kinase activity
GH723_RS06935	COG0233	cytoplasmic translational termination
GH723_RS06940	COG0575	Belongs to the CDS family
GH723_RS06945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GH723_RS06955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GH723_RS06965	COG0442	prolyl-tRNA aminoacylation
GH723_RS06970	COG0779	Required for maturation of 30S ribosomal subunits
GH723_RS06985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GH723_RS06995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GH723_RS07000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GH723_RS07005	COG0196	riboflavin kinase activity
GH723_RS07010	COG1946	Acyl-CoA thioesterase
GH723_RS07015	COG1960	acyl-CoA dehydrogenase activity
GH723_RS07030	COG2050	protein possibly involved in aromatic compounds catabolism
GH723_RS07040	COG2365	Tyrosine phosphatase family
GH723_RS07060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH723_RS07075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH723_RS07085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH723_RS07090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GH723_RS07100	COG0612	Peptidase, M16
GH723_RS07105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GH723_RS07125	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS07135	COG1162	GTPase activity
GH723_RS07150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH723_RS07155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GH723_RS07165	COG1674	ftsk spoiiie
GH723_RS07190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH723_RS07200	COG1215	transferase activity, transferring glycosyl groups
GH723_RS07205	COG1058	Belongs to the CinA family
GH723_RS07205	COG1546	Belongs to the CinA family
GH723_RS07210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS07220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH723_RS07225	COG0514	ATP-dependent DNA helicase (RecQ)
GH723_RS07230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GH723_RS07240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH723_RS07250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GH723_RS07255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GH723_RS07260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GH723_RS07270	COG5001	Diguanylate cyclase
GH723_RS07270	COG3300	MHYT domain
GH723_RS07275	COG0427	acetyl-CoA hydrolase
GH723_RS07280	COG2171	N-acyltransferase activity
GH723_RS07325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GH723_RS07350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH723_RS07355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GH723_RS07440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GH723_RS07455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GH723_RS07460	COG2272	Belongs to the type-B carboxylesterase lipase family
GH723_RS07470	COG1960	acyl-CoA dehydrogenase activity
GH723_RS07475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GH723_RS07485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GH723_RS07490	COG2832	Protein of unknown function (DUF454)
GH723_RS07495	COG0515	serine threonine protein kinase
GH723_RS07495	COG2815	serine threonine protein kinase
GH723_RS07505	COG0287	Prephenate dehydrogenase
GH723_RS07505	COG1605	Chorismate mutase
GH723_RS07510	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS07520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GH723_RS07565	COG2814	Major facilitator Superfamily
GH723_RS07570	COG2985	domain, Protein
GH723_RS07570	COG0569	domain protein
GH723_RS07575	COG2133	pyrroloquinoline quinone binding
GH723_RS07595	COG1609	Transcriptional regulator
GH723_RS07600	COG1653	transport
GH723_RS07605	COG1175	transmembrane transport
GH723_RS07610	COG0395	ABC-type sugar transport system, permease component
GH723_RS07620	COG0366	Alpha amylase catalytic
GH723_RS07640	COG0346	lactoylglutathione lyase activity
GH723_RS07645	COG2186	Transcriptional regulator
GH723_RS07655	COG0444	Belongs to the ABC transporter superfamily
GH723_RS07660	COG0747	negative chemotaxis
GH723_RS07670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH723_RS07675	COG4608	Belongs to the ABC transporter superfamily
GH723_RS07685	COG0154	amidase activity
GH723_RS07690	COG0154	amidase activity
GH723_RS07700	COG0477	Major facilitator Superfamily
GH723_RS07730	COG1741	Belongs to the pirin family
GH723_RS07735	COG1234	tRNA 3'-trailer cleavage
GH723_RS07765	COG1643	Atp-dependent helicase
GH723_RS07780	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH723_RS07790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH723_RS07800	COG3022	response to hydroperoxide
GH723_RS07835	COG0598	Magnesium transport protein CorA
GH723_RS07850	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS07855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH723_RS07860	COG1024	Enoyl-CoA hydratase
GH723_RS07865	COG3559	Exporter of polyketide antibiotics
GH723_RS07870	COG1131	(ABC) transporter
GH723_RS07885	COG5001	Diguanylate cyclase
GH723_RS07885	COG3300	MHYT domain
GH723_RS07890	COG0110	maltose O-acetyltransferase activity
GH723_RS07905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH723_RS07960	COG1950	PFAM Membrane protein of
GH723_RS07970	COG1435	thymidine kinase activity
GH723_RS07975	COG1329	Transcriptional regulator
GH723_RS07985	COG5001	Diguanylate cyclase
GH723_RS07985	COG3300	MHYT domain
GH723_RS08005	COG1960	acyl-CoA dehydrogenase activity
GH723_RS08010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GH723_RS08030	COG0386	Belongs to the glutathione peroxidase family
GH723_RS08035	COG0513	Belongs to the DEAD box helicase family
GH723_RS08060	COG0577	efflux transmembrane transporter activity
GH723_RS08065	COG0577	efflux transmembrane transporter activity
GH723_RS08075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH723_RS08085	COG2207	Transcriptional regulator
GH723_RS08100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH723_RS08155	COG1295	ribonuclease BN
GH723_RS08205	COG2814	Major facilitator Superfamily
GH723_RS08210	COG0776	regulation of translation
GH723_RS08225	COG1960	acyl-CoA dehydrogenase activity
GH723_RS08245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GH723_RS08250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH723_RS08255	COG0583	DNA-binding transcription factor activity
GH723_RS08265	COG1840	ABC-type Fe3 transport system, periplasmic component
GH723_RS08270	COG1178	ABC-type Fe3 transport system permease component
GH723_RS08275	COG3842	ATPase activity
GH723_RS08285	COG2188	Transcriptional regulator
GH723_RS08300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH723_RS08305	COG0069	glutamate synthase activity
GH723_RS08305	COG0070	glutamate synthase
GH723_RS08305	COG0067	glutamate synthase
GH723_RS08350	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH723_RS08355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GH723_RS08365	COG0484	heat shock protein binding
GH723_RS08375	COG0667	Aldo Keto reductase
GH723_RS08385	COG1316	TRANSCRIPTIONal
GH723_RS08390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GH723_RS08400	COG0302	gtp cyclohydrolase
GH723_RS08405	COG1960	acyl-CoA dehydrogenase activity
GH723_RS08425	COG3842	ATPase activity
GH723_RS08435	COG0028	Belongs to the TPP enzyme family
GH723_RS08445	COG0596	Alpha beta hydrolase
GH723_RS08450	COG1119	ATPase activity
GH723_RS08455	COG1846	Transcriptional regulator
GH723_RS08475	COG0215	cysteine-tRNA ligase activity
GH723_RS08485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GH723_RS08515	COG1560	Kdo2-lipid A biosynthetic process
GH723_RS08520	COG0438	transferase activity, transferring glycosyl groups
GH723_RS08525	COG1704	LemA family
GH723_RS08530	COG0501	Belongs to the peptidase M48B family
GH723_RS08535	COG1470	cell adhesion involved in biofilm formation
GH723_RS08540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GH723_RS08550	COG0217	transcriptional regulatory protein
GH723_RS08585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GH723_RS08590	COG0632	four-way junction helicase activity
GH723_RS08595	COG2255	four-way junction helicase activity
GH723_RS08600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GH723_RS08605	COG0343	queuine tRNA-ribosyltransferase activity
GH723_RS08610	COG1862	Preprotein translocase
GH723_RS08615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GH723_RS08620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GH723_RS08625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH723_RS08630	COG1253	flavin adenine dinucleotide binding
GH723_RS08640	COG0124	histidyl-tRNA synthetase
GH723_RS08645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GH723_RS08670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH723_RS08685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GH723_RS08700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GH723_RS08710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GH723_RS08715	COG0006	proline dipeptidase activity
GH723_RS08720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH723_RS08725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH723_RS08730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GH723_RS08735	COG0540	Belongs to the ATCase OTCase family
GH723_RS08740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GH723_RS08745	COG0505	Belongs to the CarA family
GH723_RS08750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GH723_RS08755	COG0167	dihydroorotate dehydrogenase activity
GH723_RS08760	COG0284	orotidine-5'-phosphate decarboxylase activity
GH723_RS08780	COG0194	GDP metabolic process
GH723_RS08785	COG1758	RNA polymerase activity
GH723_RS08795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GH723_RS08805	COG4552	Acetyltransferase involved in intracellular survival and related
GH723_RS08815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GH723_RS08820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GH723_RS08820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH723_RS08825	COG0521	Mo-molybdopterin cofactor biosynthetic process
GH723_RS08825	COG0315	cyclic pyranopterin monophosphate synthase activity
GH723_RS08830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH723_RS08830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH723_RS08840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GH723_RS08855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GH723_RS08860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GH723_RS08865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GH723_RS08870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH723_RS08875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GH723_RS08880	COG0072	phenylalanine-tRNA ligase activity
GH723_RS08890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GH723_RS08895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GH723_RS08900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GH723_RS08905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH723_RS08910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GH723_RS08915	COG1438	arginine binding
GH723_RS08920	COG0137	argininosuccinate synthase activity
GH723_RS08925	COG0165	Argininosuccinate lyase
GH723_RS08940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GH723_RS08950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GH723_RS08955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GH723_RS08980	COG0604	alcohol dehydrogenase
GH723_RS08990	COG0674	pyruvate-flavodoxin oxidoreductase activity
GH723_RS08990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GH723_RS08995	COG1013	pyruvate-flavodoxin oxidoreductase activity
GH723_RS09005	COG0647	UMP catabolic process
GH723_RS09015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GH723_RS09020	COG0497	DNA recombination
GH723_RS09050	COG0504	CTP synthase activity
GH723_RS09080	COG0596	Alpha beta hydrolase
GH723_RS09085	COG0180	Tryptophanyl-tRNA synthetase
GH723_RS09090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GH723_RS09095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GH723_RS09100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GH723_RS09105	COG1187	pseudouridine synthase activity
GH723_RS09110	COG0287	Prephenate dehydrogenase
GH723_RS09115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GH723_RS09130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH723_RS09150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GH723_RS09160	COG1160	GTP binding
GH723_RS09180	COG2135	peptidase activity
GH723_RS09205	COG1716	ATPase activity
GH723_RS09215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GH723_RS09240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GH723_RS09250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GH723_RS09255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GH723_RS09275	COG0596	Alpha beta hydrolase
GH723_RS09275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH723_RS09285	COG1704	LemA family
GH723_RS09295	COG2070	2-Nitropropane dioxygenase
GH723_RS09315	COG1024	Enoyl-CoA hydratase
GH723_RS09365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH723_RS09385	COG0681	Belongs to the peptidase S26 family
GH723_RS09405	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GH723_RS09410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GH723_RS09415	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GH723_RS09425	COG4122	O-methyltransferase activity
GH723_RS09430	COG1222	aaa ATPase
GH723_RS09455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH723_RS09465	COG0037	tRNA processing
GH723_RS09470	COG2104	thiamine diphosphate biosynthetic process
GH723_RS09510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH723_RS09510	COG1042	CoA-binding domain protein
GH723_RS09510	COG0045	succinate-CoA ligase (ADP-forming) activity
GH723_RS09515	COG1309	transcriptional regulator
GH723_RS09525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GH723_RS09540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GH723_RS09545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GH723_RS09550	COG0363	glucosamine-6-phosphate deaminase activity
GH723_RS09555	COG1611	Belongs to the LOG family
GH723_RS09565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH723_RS09585	COG2255	four-way junction helicase activity
GH723_RS09595	COG1217	gtp-binding protein TYPA
GH723_RS09615	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GH723_RS09620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GH723_RS09625	COG0746	molybdenum cofactor guanylyltransferase activity
GH723_RS09640	COG2267	carboxylic ester hydrolase activity
GH723_RS09650	COG1960	acyl-CoA dehydrogenase activity
GH723_RS09660	COG0584	glycerophosphoryl diester phosphodiesterase
GH723_RS09670	COG0277	FAD linked oxidase domain protein
GH723_RS09675	COG1024	Enoyl-CoA hydratase
GH723_RS09685	COG0444	Belongs to the ABC transporter superfamily
GH723_RS09700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH723_RS09705	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS09735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH723_RS09750	COG2755	lipolytic protein G-D-S-L family
GH723_RS09750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GH723_RS09765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH723_RS09800	COG2018	Roadblock/LC7 domain
GH723_RS09815	COG1362	aminopeptidase activity
GH723_RS09825	COG3328	transposase activity
GH723_RS09840	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GH723_RS09855	COG1132	(ABC) transporter
GH723_RS09890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GH723_RS09900	COG1937	Protein conserved in bacteria
GH723_RS09920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH723_RS09935	COG0737	Belongs to the 5'-nucleotidase family
GH723_RS09945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GH723_RS09955	COG1272	protein, Hemolysin III
GH723_RS09960	COG0662	Cupin 2, conserved barrel domain protein
GH723_RS09965	COG0534	Mate efflux family protein
GH723_RS09975	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GH723_RS09990	COG3872	metal-dependent enzyme
GH723_RS10005	COG0557	exoribonuclease II activity
GH723_RS10025	COG0438	transferase activity, transferring glycosyl groups
GH723_RS10050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH723_RS10050	COG0561	phosphatase activity
GH723_RS10055	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GH723_RS10070	COG3634	alkyl hydroperoxide reductase activity
GH723_RS10075	COG0583	DNA-binding transcription factor activity
GH723_RS10080	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS10110	COG3263	regulation of cellular component size
GH723_RS10115	COG0702	epimerase
GH723_RS10130	COG2154	pterin-4-alpha-carbinolamine dehydratase
GH723_RS10135	COG1733	regulation of RNA biosynthetic process
GH723_RS10140	COG1960	acyl-CoA dehydrogenase activity
GH723_RS10150	COG3220	belongs to the UPF0276 family
GH723_RS10160	COG0750	zinc metalloprotease
GH723_RS10190	COG3012	SEC-C Motif Domain Protein
GH723_RS10205	COG1061	Type III restriction enzyme res subunit
GH723_RS10240	COG1074	ATP-dependent DNA helicase activity
GH723_RS10260	COG4608	Belongs to the ABC transporter superfamily
GH723_RS10275	COG0601	transmembrane transport
GH723_RS10280	COG0747	negative chemotaxis
GH723_RS10285	COG0149	triose-phosphate isomerase activity
GH723_RS10290	COG0126	phosphoglycerate kinase activity
GH723_RS10295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GH723_RS10300	COG1660	Displays ATPase and GTPase activities
GH723_RS10305	COG2226	methyltransferase
GH723_RS10335	COG0322	excinuclease ABC activity
GH723_RS10345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GH723_RS10360	COG0463	Glycosyl transferase, family 2
GH723_RS10365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GH723_RS10370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GH723_RS10380	COG0556	nucleotide-excision repair
GH723_RS10385	COG0237	dephospho-CoA kinase activity
GH723_RS10390	COG4585	Histidine kinase
GH723_RS10480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH723_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS10490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH723_RS10495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH723_RS10500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GH723_RS10510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH723_RS10515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GH723_RS10520	COG0494	nUDIX hydrolase
GH723_RS10525	COG0776	regulation of translation
GH723_RS10540	COG0159	tryptophan synthase activity
GH723_RS10545	COG0133	tryptophan synthase activity
GH723_RS10550	COG0135	phosphoribosylanthranilate isomerase activity
GH723_RS10555	COG0134	indole-3-glycerol-phosphate synthase activity
GH723_RS10560	COG0484	heat shock protein binding
GH723_RS10570	COG0354	folic acid binding
GH723_RS10575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH723_RS10580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GH723_RS10580	COG0140	phosphoribosyl-ATP diphosphatase activity
GH723_RS10585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GH723_RS10590	COG0107	imidazoleglycerol-phosphate synthase activity
GH723_RS10595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GH723_RS10600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GH723_RS10605	COG0131	Imidazoleglycerol-phosphate dehydratase
GH723_RS10610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH723_RS10615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GH723_RS10625	COG0454	-acetyltransferase
GH723_RS10625	COG0456	acetyltransferase
GH723_RS10635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GH723_RS10640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GH723_RS10655	COG1960	acyl-CoA dehydrogenase activity
GH723_RS10660	COG2226	methyltransferase
GH723_RS10665	COG1169	isochorismate synthase
GH723_RS10670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GH723_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS10705	COG1331	Highly conserved protein containing a thioredoxin domain
GH723_RS10710	COG0778	Nitroreductase
GH723_RS10760	COG0564	pseudouridine synthase activity
GH723_RS10765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GH723_RS10770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GH723_RS10775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GH723_RS10790	COG1799	cell septum assembly
GH723_RS10800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GH723_RS10805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GH723_RS10810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GH723_RS10815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH723_RS10820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GH723_RS10825	COG0772	Belongs to the SEDS family
GH723_RS10830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GH723_RS10835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH723_RS10840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GH723_RS10845	COG0768	penicillin binding
GH723_RS10855	COG0275	rRNA processing
GH723_RS10860	COG2001	Belongs to the MraZ family
GH723_RS10870	COG4948	Mandelate Racemase Muconate Lactonizing
GH723_RS10890	COG0714	Associated with various cellular activities
GH723_RS10910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH723_RS10920	COG0463	Glycosyl transferase, family 2
GH723_RS10935	COG0745	RESPONSE REGULATOR receiver
GH723_RS10940	COG5000	phosphorelay sensor kinase activity
GH723_RS10940	COG5002	protein histidine kinase activity
GH723_RS10950	COG0205	6-phosphofructokinase activity
GH723_RS10955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GH723_RS10965	COG1309	transcriptional regulator
GH723_RS10970	COG0436	Aminotransferase
GH723_RS10975	COG1940	carbohydrate kinase activity
GH723_RS11005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH723_RS11030	COG1366	Belongs to the anti-sigma-factor antagonist family
GH723_RS11040	COG2329	Antibiotic biosynthesis monooxygenase
GH723_RS11045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GH723_RS11060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GH723_RS11065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GH723_RS11070	COG0277	FAD linked oxidase domain protein
GH723_RS11080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GH723_RS11085	COG3794	PFAM blue (type 1) copper domain protein
GH723_RS11135	COG3128	pkhd-type hydroxylase
GH723_RS11240	COG0644	oxidoreductase
GH723_RS11250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH723_RS11255	COG0358	DNA primase activity
GH723_RS11260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH723_RS11260	COG0574	Belongs to the PEP-utilizing enzyme family
GH723_RS11295	COG1381	Involved in DNA repair and RecF pathway recombination
GH723_RS11300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GH723_RS11340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GH723_RS11350	COG3328	transposase activity
GH723_RS11365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GH723_RS11430	COG2197	response regulator
GH723_RS11435	COG3851	Histidine kinase
GH723_RS11440	COG1061	Type III restriction enzyme res subunit
GH723_RS11470	COG1420	regulation of RNA biosynthetic process
GH723_RS11480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GH723_RS11480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GH723_RS11480	COG0674	pyruvate-flavodoxin oxidoreductase activity
GH723_RS11480	COG1013	pyruvate-flavodoxin oxidoreductase activity
GH723_RS11485	COG0415	Belongs to the DNA photolyase family
GH723_RS11490	COG3347	Dehydrogenase
GH723_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS11500	COG0481	GTPase activity
GH723_RS11505	COG0268	Binds directly to 16S ribosomal RNA
GH723_RS11530	COG1555	photosystem II stabilization
GH723_RS11535	COG3118	belongs to the thioredoxin family
GH723_RS11560	COG2409	Drug exporters of the RND superfamily
GH723_RS11565	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS11570	COG0495	leucyl-tRNA aminoacylation
GH723_RS11580	COG0799	negative regulation of ribosome biogenesis
GH723_RS11590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GH723_RS11595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH723_RS11600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GH723_RS11610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GH723_RS11615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GH723_RS11625	COG1842	Phage shock protein A
GH723_RS11630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GH723_RS11635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GH723_RS11660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GH723_RS11665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GH723_RS11670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GH723_RS11675	COG1530	ribonuclease E activity
GH723_RS11685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH723_RS11690	COG0772	Belongs to the SEDS family
GH723_RS11710	COG1077	Cell shape determining protein MreB Mrl
GH723_RS11715	COG0105	UTP biosynthetic process
GH723_RS11720	COG0285	dihydrofolate synthase activity
GH723_RS11725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GH723_RS11730	COG0740	serine-type endopeptidase activity
GH723_RS11735	COG0544	peptidyl-prolyl cis-trans isomerase activity
GH723_RS11750	COG2272	Belongs to the type-B carboxylesterase lipase family
GH723_RS11785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS11845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GH723_RS11875	COG3795	YCII-related domain
GH723_RS11880	COG4941	Belongs to the sigma-70 factor family
GH723_RS11895	COG2323	membrane
GH723_RS11930	COG4552	Acetyltransferase involved in intracellular survival and related
GH723_RS11935	COG1960	acyl-CoA dehydrogenase activity
GH723_RS11945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GH723_RS11960	COG0740	serine-type endopeptidase activity
GH723_RS11990	COG2814	Major facilitator Superfamily
GH723_RS12005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GH723_RS12010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GH723_RS12015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GH723_RS12025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GH723_RS12035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GH723_RS12045	COG1960	acyl-CoA dehydrogenase activity
GH723_RS12060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GH723_RS12095	COG2318	DinB family
GH723_RS12125	COG1024	Enoyl-CoA hydratase
GH723_RS12140	COG1280	lysine exporter protein (LysE YggA)
GH723_RS12145	COG2177	Part of the ABC transporter FtsEX involved in
GH723_RS12150	COG2884	Cell division ATP-binding protein ftsE
GH723_RS12165	COG0653	protein targeting
GH723_RS12170	COG2197	response regulator
GH723_RS12185	COG2364	Membrane
GH723_RS12195	COG1063	alcohol dehydrogenase
GH723_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS12210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GH723_RS12225	COG1663	tetraacyldisaccharide 4'-kinase activity
GH723_RS12225	COG2835	tetraacyldisaccharide 4'-kinase activity
GH723_RS12235	COG0463	Glycosyl transferase, family 2
GH723_RS12260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH723_RS12290	COG0297	glycogen (starch) synthase activity
GH723_RS12310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GH723_RS12315	COG0778	Nitroreductase
GH723_RS12315	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GH723_RS12330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH723_RS12335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GH723_RS12340	COG0438	transferase activity, transferring glycosyl groups
GH723_RS12360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH723_RS12365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GH723_RS12370	COG1316	TRANSCRIPTIONal
GH723_RS12380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GH723_RS12380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GH723_RS12385	COG4770	biotin carboxylase activity
GH723_RS12405	COG0390	transport system, permease component
GH723_RS12410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GH723_RS12415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GH723_RS12415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GH723_RS12465	COG0438	transferase activity, transferring glycosyl groups
GH723_RS12465	COG1216	Glycosyl transferase, family 2
GH723_RS12480	COG0438	transferase activity, transferring glycosyl groups
GH723_RS12510	COG1404	Belongs to the peptidase S8 family
GH723_RS12510	COG4412	M6 family metalloprotease domain protein
GH723_RS12515	COG2373	Large extracellular alpha-helical protein
GH723_RS12520	COG2385	sporulation resulting in formation of a cellular spore
GH723_RS12550	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GH723_RS12565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GH723_RS12590	COG0646	methionine synthase
GH723_RS12590	COG1410	methionine synthase
GH723_RS12595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GH723_RS12610	COG3300	MHYT domain
GH723_RS12610	COG5001	Diguanylate cyclase
GH723_RS12620	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH723_RS12625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH723_RS12635	COG2193	ferroxidase activity
GH723_RS12645	COG1090	epimerase
GH723_RS12650	COG1999	signal sequence binding
GH723_RS12675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH723_RS12680	COG0475	glutathione-regulated potassium exporter activity
GH723_RS12690	COG0069	glutamate synthase activity
GH723_RS12725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GH723_RS12745	COG3132	Protein of unknown function, DUF480
GH723_RS12760	COG2340	Cysteine-rich secretory protein family
GH723_RS12775	COG1960	acyl-CoA dehydrogenase activity
GH723_RS12785	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
GH723_RS12795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH723_RS12805	COG0396	ATPase activity
GH723_RS12810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GH723_RS12815	COG0822	iron-sulfur transferase activity
GH723_RS12825	COG0789	Transcriptional regulator
GH723_RS12845	COG0396	ATPase activity
GH723_RS12855	COG0719	Fe-S assembly protein
GH723_RS12865	COG0719	Fe-S assembly protein
GH723_RS12870	COG3300	MHYT domain
GH723_RS12870	COG5001	Diguanylate cyclase
GH723_RS12875	COG1132	(ABC) transporter
GH723_RS12885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GH723_RS12940	COG5001	Diguanylate cyclase
GH723_RS12940	COG3447	MASE1 domain protein
GH723_RS12940	COG5002	protein histidine kinase activity
GH723_RS12970	COG2301	Belongs to the HpcH HpaI aldolase family
GH723_RS12980	COG0114	fumarate hydratase activity
GH723_RS12995	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GH723_RS12995	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GH723_RS13015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH723_RS13030	COG4221	oxidoreductase activity
GH723_RS13040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GH723_RS13045	COG1595	DNA-templated transcription, initiation
GH723_RS13060	COG0488	(ABC) transporter
GH723_RS13075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS13080	COG1309	transcriptional regulator
GH723_RS13090	COG0673	inositol 2-dehydrogenase activity
GH723_RS13140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH723_RS13145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GH723_RS13170	COG3608	succinylglutamate desuccinylase aspartoacylase
GH723_RS13170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GH723_RS13185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GH723_RS13205	COG0148	phosphopyruvate hydratase activity
GH723_RS13215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH723_RS13215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH723_RS13225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GH723_RS13230	COG1215	transferase activity, transferring glycosyl groups
GH723_RS13250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GH723_RS13265	COG0500	methyltransferase
GH723_RS13275	COG1216	Glycosyl transferase, family 2
GH723_RS13310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH723_RS13315	COG1216	Glycosyl transferase, family 2
GH723_RS13320	COG3307	-O-antigen
GH723_RS13325	COG0438	transferase activity, transferring glycosyl groups
GH723_RS13345	COG3956	TIGRFAM MazG family protein
GH723_RS13350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH723_RS13360	COG0193	aminoacyl-tRNA hydrolase activity
GH723_RS13365	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GH723_RS13370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GH723_RS13375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GH723_RS13380	COG1476	TRANSCRIPTIONal
GH723_RS13400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GH723_RS13420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GH723_RS13430	COG0084	hydrolase, TatD family'
GH723_RS13435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH723_RS13490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GH723_RS13495	COG1120	ATPase activity
GH723_RS13505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH723_RS13515	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GH723_RS13525	COG0012	GTP binding
GH723_RS13535	COG1744	ABC transporter substrate-binding protein PnrA-like
GH723_RS13540	COG3845	ABC transporter
GH723_RS13545	COG4603	Belongs to the binding-protein-dependent transport system permease family
GH723_RS13550	COG1079	Belongs to the binding-protein-dependent transport system permease family
GH723_RS13560	COG0295	cytidine deaminase activity
GH723_RS13565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GH723_RS13570	COG2095	MarC family integral membrane protein
GH723_RS13575	COG2318	DinB family
GH723_RS13590	COG1678	Uncharacterized ACR, COG1678
GH723_RS13595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GH723_RS13625	COG1012	belongs to the aldehyde dehydrogenase family
GH723_RS13645	COG1012	belongs to the aldehyde dehydrogenase family
GH723_RS13650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GH723_RS13655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GH723_RS13680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH723_RS13705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH723_RS13760	COG0640	Transcriptional regulator
GH723_RS13775	COG2814	Major facilitator Superfamily
GH723_RS13780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH723_RS13785	COG0308	aminopeptidase N
GH723_RS13790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GH723_RS13815	COG0154	amidase activity
GH723_RS13825	COG0009	L-threonylcarbamoyladenylate synthase
GH723_RS13845	COG0315	cyclic pyranopterin monophosphate synthase activity
GH723_RS13865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GH723_RS13870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GH723_RS13895	COG0477	Major facilitator Superfamily
GH723_RS13900	COG0312	modulator of DNA gyrase
GH723_RS13905	COG0312	modulator of DNA gyrase
GH723_RS13920	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GH723_RS13975	COG1012	belongs to the aldehyde dehydrogenase family
GH723_RS13980	COG1320	monovalent cation:proton antiporter activity
GH723_RS13985	COG2212	antiporter activity
GH723_RS13995	COG0651	ATP synthesis coupled electron transport
GH723_RS14000	COG1006	Multisubunit Na H antiporter MnhC subunit
GH723_RS14005	COG2111	Na H antiporter
GH723_RS14010	COG0488	(ABC) transporter
GH723_RS14035	COG3588	fructose-bisphosphate aldolase
GH723_RS14060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GH723_RS14065	COG0187	DNA topoisomerase II activity
GH723_RS14070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH723_RS14085	COG0463	Glycosyl transferase, family 2
GH723_RS14090	COG1876	peptidase activity
GH723_RS14095	COG1126	abc transporter atp-binding protein
GH723_RS14100	COG0765	amino acid transport
GH723_RS14105	COG4597	amino acid ABC transporter
GH723_RS14110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH723_RS14120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH723_RS14135	COG1192	Involved in chromosome partitioning
GH723_RS14145	COG0384	phenazine biosynthesis protein PhzF
GH723_RS14170	COG1132	(ABC) transporter
GH723_RS14175	COG1132	(ABC) transporter
GH723_RS14180	COG2030	dehydratase
GH723_RS14225	COG0420	3'-5' exonuclease activity
GH723_RS14230	COG1335	isochorismatase
GH723_RS14255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH723_RS14260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH723_RS14265	COG0366	Alpha amylase catalytic
GH723_RS14285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GH723_RS14290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH723_RS14295	COG1120	ATPase activity
GH723_RS14300	COG1492	cobalamin metabolic process
GH723_RS14315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GH723_RS14325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GH723_RS14335	COG2814	Major facilitator Superfamily
GH723_RS14360	COG0243	molybdopterin cofactor binding
GH723_RS14370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH723_RS14415	COG0501	Belongs to the peptidase M48B family
GH723_RS14420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH723_RS14425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH723_RS14425	COG1648	precorrin-2 dehydrogenase activity
GH723_RS14435	COG0686	Belongs to the AlaDH PNT family
GH723_RS14465	COG1957	nucleoside hydrolase
GH723_RS14475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH723_RS14475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH723_RS14480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH723_RS14485	COG1876	peptidase activity
GH723_RS14495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH723_RS14510	COG2205	protein histidine kinase activity
GH723_RS14515	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS14520	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS14600	COG3119	arylsulfatase activity
GH723_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS14620	COG4941	Belongs to the sigma-70 factor family
GH723_RS14635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS14655	COG1742	UPF0060 membrane protein
GH723_RS14665	COG1999	signal sequence binding
GH723_RS14680	COG1968	undecaprenyl-diphosphatase activity
GH723_RS14705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH723_RS14705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GH723_RS14730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH723_RS14800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH723_RS14805	COG0649	NAD binding
GH723_RS14810	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH723_RS14820	COG0713	ATP synthesis coupled electron transport
GH723_RS14825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH723_RS14835	COG1007	ATP synthesis coupled electron transport
GH723_RS14870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GH723_RS14895	COG3328	transposase activity
GH723_RS14910	COG0563	adenylate kinase activity
GH723_RS14915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GH723_RS14925	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GH723_RS14935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GH723_RS14940	COG1611	Belongs to the LOG family
GH723_RS14945	COG2217	Heavy metal translocating P-type atpase
GH723_RS14960	COG1937	Protein conserved in bacteria
GH723_RS14965	COG2801	Transposase and inactivated derivatives
GH723_RS14990	COG0640	Transcriptional regulator
GH723_RS15035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GH723_RS15040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GH723_RS15045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GH723_RS15050	COG0569	domain protein
GH723_RS15065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GH723_RS15080	COG0058	SHG alpha-glucan phosphorylase activity
GH723_RS15090	COG1012	belongs to the aldehyde dehydrogenase family
GH723_RS15110	COG2264	protein methyltransferase activity
GH723_RS15120	COG0297	glycogen (starch) synthase activity
GH723_RS15125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GH723_RS15135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GH723_RS15150	COG1215	transferase activity, transferring glycosyl groups
GH723_RS15155	COG1091	dTDP-4-dehydrorhamnose reductase activity
GH723_RS15195	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS15215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GH723_RS15225	COG0366	Alpha amylase catalytic
GH723_RS15230	COG0366	Alpha amylase catalytic
GH723_RS15285	COG0248	Ppx GppA phosphatase
GH723_RS15315	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS15325	COG0579	oxidoreductase
GH723_RS15330	COG0450	alkyl hydroperoxide reductase
GH723_RS15340	COG1136	(ABC) transporter
GH723_RS15345	COG0577	efflux transmembrane transporter activity
GH723_RS15360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH723_RS15375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GH723_RS15390	COG1201	RNA secondary structure unwinding
GH723_RS15400	COG0561	phosphatase activity
GH723_RS15430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GH723_RS15435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GH723_RS15455	COG0488	(ABC) transporter
GH723_RS15460	COG1490	D-aminoacyl-tRNA deacylase activity
GH723_RS15475	COG1595	DNA-templated transcription, initiation
GH723_RS15480	COG0297	glycogen (starch) synthase activity
GH723_RS15505	COG1946	Acyl-CoA thioesterase
GH723_RS15525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GH723_RS15530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS15540	COG0243	molybdopterin cofactor binding
GH723_RS15545	COG2223	nitrite transmembrane transporter activity
GH723_RS15555	COG2146	nitrite reductase [NAD(P)H] activity
GH723_RS15555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GH723_RS15560	COG2146	nitrite reductase [NAD(P)H] activity
GH723_RS15560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GH723_RS15580	COG1960	acyl-CoA dehydrogenase activity
GH723_RS15595	COG1404	Belongs to the peptidase S8 family
GH723_RS15605	COG1609	Transcriptional regulator
GH723_RS15640	COG2072	flavoprotein involved in K transport
GH723_RS15645	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GH723_RS15650	COG3695	enzyme binding
GH723_RS15660	COG0626	cystathionine gamma-synthase activity
GH723_RS15665	COG2226	methyltransferase
GH723_RS15685	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GH723_RS15700	COG0183	Belongs to the thiolase family
GH723_RS15705	COG1946	Acyl-CoA thioesterase
GH723_RS15720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GH723_RS15745	COG1606	tRNA processing
GH723_RS15750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH723_RS15770	COG4762	Protein conserved in bacteria
GH723_RS15780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GH723_RS15800	COG4177	L-phenylalanine transmembrane transporter activity
GH723_RS15820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GH723_RS15835	COG4044	May play a role in the intracellular transport of hydrophobic ligands
GH723_RS15860	COG0459	protein refolding
GH723_RS15865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GH723_RS15875	COG0463	Glycosyl transferase, family 2
GH723_RS15890	COG1929	Belongs to the glycerate kinase type-1 family
GH723_RS15950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GH723_RS15950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GH723_RS15965	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GH723_RS15970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GH723_RS16005	COG0142	geranyltranstransferase activity
GH723_RS16015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS16030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GH723_RS16035	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GH723_RS16050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GH723_RS16055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GH723_RS16080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GH723_RS16090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GH723_RS16100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH723_RS16105	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GH723_RS16110	COG0037	tRNA processing
GH723_RS16130	COG1595	DNA-templated transcription, initiation
GH723_RS16140	COG2205	protein histidine kinase activity
GH723_RS16165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GH723_RS16170	COG2814	Major facilitator Superfamily
GH723_RS16180	COG2172	sigma factor antagonist activity
GH723_RS16185	COG1366	Belongs to the anti-sigma-factor antagonist family
GH723_RS16190	COG1111	helicase
GH723_RS16190	COG1205	dead DEAH box helicase
GH723_RS16245	COG1058	Belongs to the CinA family
GH723_RS16245	COG1546	Belongs to the CinA family
GH723_RS16250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH723_RS16270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GH723_RS16275	COG1917	Cupin 2, conserved barrel domain protein
GH723_RS16280	COG5285	phytanoyl-CoA dioxygenase
GH723_RS16285	COG5001	Diguanylate cyclase
GH723_RS16305	COG0174	glutamine synthetase
GH723_RS16310	COG0745	RESPONSE REGULATOR receiver
GH723_RS16315	COG1278	Cold shock
GH723_RS16325	COG0251	oxidation-reduction process
GH723_RS16335	COG0316	Belongs to the HesB IscA family
GH723_RS16350	COG2076	Multidrug Resistance protein
GH723_RS16385	COG0003	Pfam Anion-transporting ATPase
GH723_RS16390	COG1366	Belongs to the anti-sigma-factor antagonist family
GH723_RS16430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH723_RS16435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GH723_RS16440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GH723_RS16450	COG1191	sigma factor activity
GH723_RS16465	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH723_RS16470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GH723_RS16475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GH723_RS16475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GH723_RS16495	COG0656	L-ascorbic acid biosynthetic process
GH723_RS16505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH723_RS16510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GH723_RS16515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH723_RS16525	COG0412	Dienelactone hydrolase
GH723_RS16530	COG1793	dna ligase
GH723_RS16555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH723_RS16555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH723_RS16600	COG0501	Belongs to the peptidase M48B family
GH723_RS16620	COG0346	lactoylglutathione lyase activity
GH723_RS16625	COG0604	alcohol dehydrogenase
GH723_RS16635	COG0183	Belongs to the thiolase family
GH723_RS16645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GH723_RS16650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GH723_RS16670	COG0590	tRNA wobble adenosine to inosine editing
GH723_RS16690	COG5001	Diguanylate cyclase
GH723_RS16695	COG1570	exodeoxyribonuclease VII activity
GH723_RS16705	COG0142	geranyltranstransferase activity
GH723_RS16750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GH723_RS16760	COG0778	Nitroreductase
GH723_RS16770	COG3214	Protein conserved in bacteria
GH723_RS16775	COG0372	Belongs to the citrate synthase family
GH723_RS16780	COG0372	Belongs to the citrate synthase family
GH723_RS16795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH723_RS16805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH723_RS16815	COG0574	Belongs to the PEP-utilizing enzyme family
GH723_RS16815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH723_RS16820	COG1285	pathogenesis
GH723_RS16825	COG0589	response to stress
GH723_RS16840	COG0789	Transcriptional regulator
GH723_RS16850	COG0515	serine threonine protein kinase
GH723_RS16875	COG1022	Amp-dependent synthetase and ligase
GH723_RS16880	COG0183	Belongs to the thiolase family
GH723_RS16895	COG0512	Glutamine amidotransferase of anthranilate synthase
GH723_RS16900	COG0515	serine threonine protein kinase
GH723_RS16900	COG2815	serine threonine protein kinase
GH723_RS16915	COG0631	protein serine/threonine phosphatase activity
GH723_RS16950	COG0667	Aldo Keto reductase
GH723_RS16965	COG0183	Belongs to the thiolase family
GH723_RS16970	COG1960	acyl-CoA dehydrogenase activity
GH723_RS17025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH723_RS17030	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GH723_RS17035	COG1691	(AIR) carboxylase
GH723_RS17040	COG0077	Prephenate dehydratase
GH723_RS17050	COG2373	Large extracellular alpha-helical protein
GH723_RS17095	COG3706	GGDEF domain
GH723_RS17115	COG2172	sigma factor antagonist activity
GH723_RS17145	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GH723_RS17155	COG1401	restriction endodeoxyribonuclease activity
GH723_RS17200	COG2409	Drug exporters of the RND superfamily
GH723_RS17205	COG4585	Histidine kinase
GH723_RS17210	COG2197	response regulator
GH723_RS17230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH723_RS17240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GH723_RS17265	COG0243	molybdopterin cofactor binding
GH723_RS17270	COG0437	4 iron, 4 sulfur cluster binding
GH723_RS17290	COG2267	carboxylic ester hydrolase activity
GH723_RS17300	COG1073	alpha beta
GH723_RS17315	COG2226	methyltransferase
GH723_RS17320	COG0339	signal peptide processing
GH723_RS17325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH723_RS17330	COG3620	sequence-specific DNA binding
GH723_RS17330	COG0617	tRNA 3'-terminal CCA addition
GH723_RS17330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GH723_RS17340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GH723_RS17345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GH723_RS17345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GH723_RS17360	COG1131	(ABC) transporter
GH723_RS17385	COG2010	Cytochrome c
GH723_RS17385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GH723_RS17400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH723_RS17405	COG0109	protoheme IX farnesyltransferase activity
GH723_RS17415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GH723_RS17470	COG0582	viral genome integration into host DNA
GH723_RS17480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH723_RS17495	COG1595	DNA-templated transcription, initiation
GH723_RS17530	COG2239	Acts as a magnesium transporter
GH723_RS17540	COG2119	membrane
GH723_RS17555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GH723_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
GH723_RS17565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GH723_RS17570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GH723_RS17575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH723_RS17585	COG0047	phosphoribosylformylglycinamidine synthase activity
GH723_RS17600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GH723_RS17605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GH723_RS17615	COG0151	Belongs to the GarS family
GH723_RS17620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GH723_RS17640	COG0542	response to heat
GH723_RS17645	COG0789	Transcriptional regulator
GH723_RS17650	COG0484	heat shock protein binding
GH723_RS17655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GH723_RS17660	COG0443	Heat shock 70 kDa protein
GH723_RS17665	COG0588	phosphoglycerate mutase activity
GH723_RS17695	COG0789	Transcriptional regulator
GH723_RS17705	COG0513	Belongs to the DEAD box helicase family
GH723_RS17710	COG0840	transmembrane signaling receptor activity
GH723_RS17720	COG0004	ammonium transporteR
GH723_RS17725	COG0745	RESPONSE REGULATOR receiver
GH723_RS17730	COG0247	lactate metabolic process
GH723_RS17730	COG2181	nitrate reductase activity
GH723_RS17740	COG0717	Belongs to the dCTP deaminase family
GH723_RS17790	COG1002	Type II restriction enzyme, methylase subunits
GH723_RS17795	COG2226	methyltransferase
GH723_RS17810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GH723_RS17870	COG0318	PFAM AMP-dependent synthetase and ligase
GH723_RS17890	COG1376	ErfK ybiS ycfS ynhG family protein
GH723_RS17915	COG2197	response regulator
GH723_RS17925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GH723_RS17945	COG1136	(ABC) transporter
GH723_RS17945	COG0577	efflux transmembrane transporter activity
GH723_RS17965	COG0424	maF-like protein
GH723_RS17970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH723_RS17975	COG2313	pseudouridylate synthase activity
GH723_RS18005	COG1136	(ABC) transporter
GH723_RS18010	COG0577	efflux transmembrane transporter activity
GH723_RS18025	COG1937	Protein conserved in bacteria
GH723_RS18030	COG5001	Diguanylate cyclase
GH723_RS18030	COG3300	MHYT domain
GH723_RS18035	COG1482	cell wall glycoprotein biosynthetic process
GH723_RS18055	COG0714	Associated with various cellular activities
GH723_RS18080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GH723_RS18100	COG2268	Band 7 protein
GH723_RS18125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH723_RS18140	COG0583	DNA-binding transcription factor activity
GH723_RS18145	COG1131	(ABC) transporter
GH723_RS18175	COG0305	Participates in initiation and elongation during chromosome replication
GH723_RS18180	COG0359	binds to the 23S rRNA
GH723_RS18185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GH723_RS18195	COG0360	Binds together with S18 to 16S ribosomal RNA
GH723_RS18210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GH723_RS18220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GH723_RS18230	COG2267	carboxylic ester hydrolase activity
GH723_RS18230	COG2226	methyltransferase
GH723_RS18235	COG1063	alcohol dehydrogenase
GH723_RS18240	COG1496	oxidoreductase activity
GH723_RS18250	COG0617	tRNA 3'-terminal CCA addition
GH723_RS18255	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH723_RS18260	COG0454	-acetyltransferase
GH723_RS18260	COG0456	acetyltransferase
GH723_RS18270	COG1307	EDD domain protein, DegV family
GH723_RS18275	COG0515	serine threonine protein kinase
GH723_RS18275	COG2815	serine threonine protein kinase
GH723_RS18295	COG0492	ferredoxin-NADP+ reductase activity
GH723_RS18310	COG1192	Involved in chromosome partitioning
GH723_RS18315	COG0357	Ribosomal RNA small subunit methyltransferase G
GH723_RS18325	COG0706	membrane insertase activity
GH723_RS18330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GH723_RS18335	COG0594	ribonuclease P activity
GH723_RS18340	COG0230	Belongs to the bacterial ribosomal protein bL34 family