locus-tag	class	description
IL_RS00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IL_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IL_RS00040	COG0751	glycine-tRNA ligase activity
IL_RS00050	COG2818	Glycosylase
IL_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
IL_RS00065	COG0183	Belongs to the thiolase family
IL_RS00070	COG1250	3-hydroxyacyl-CoA dehydrogenase
IL_RS00070	COG1024	Enoyl-CoA hydratase
IL_RS00075	COG0741	lytic transglycosylase activity
IL_RS00080	COG0006	proline dipeptidase activity
IL_RS00085	COG1739	Uncharacterized protein family UPF0029
IL_RS00090	COG0569	domain protein
IL_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IL_RS00105	COG0242	peptide deformylase activity
IL_RS00110	COG0758	DNA mediated transformation
IL_RS00115	COG2922	Belongs to the Smg family
IL_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
IL_RS00130	COG0408	coproporphyrinogen oxidase activity
IL_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IL_RS00140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IL_RS00140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IL_RS00145	COG0697	spore germination
IL_RS00150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IL_RS00160	COG3078	GTPase activator activity
IL_RS00170	COG1045	serine acetyltransferase
IL_RS00175	COG0840	transmembrane signaling receptor activity
IL_RS00180	COG1278	Cold shock
IL_RS00185	COG1335	isochorismatase
IL_RS00190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IL_RS00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IL_RS00210	COG0823	Involved in the tonB-independent uptake of proteins
IL_RS00210	COG4946	Tricorn protease homolog
IL_RS00210	COG1506	peptidase
IL_RS00220	COG1271	oxidase subunit
IL_RS00225	COG1294	oxidase, subunit
IL_RS00230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IL_RS00270	COG0697	spore germination
IL_RS00275	COG0583	DNA-binding transcription factor activity
IL_RS00280	COG1595	DNA-templated transcription, initiation
IL_RS00305	COG3550	peptidyl-serine autophosphorylation
IL_RS00340	COG3118	belongs to the thioredoxin family
IL_RS00345	COG1238	metal cluster binding
IL_RS00365	COG1309	transcriptional regulator
IL_RS00370	COG1012	belongs to the aldehyde dehydrogenase family
IL_RS00380	COG1770	oligopeptidase
IL_RS00385	COG0783	Belongs to the Dps family
IL_RS00410	COG1764	response to oxidative stress
IL_RS00415	COG1846	Transcriptional regulator
IL_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
IL_RS00450	COG1368	sulfuric ester hydrolase activity
IL_RS00455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IL_RS00465	COG0318	PFAM AMP-dependent synthetase and ligase
IL_RS00490	COG0642	Histidine kinase
IL_RS00530	COG1335	isochorismatase
IL_RS00550	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IL_RS00560	COG4221	oxidoreductase activity
IL_RS00565	COG0672	)-iron permease
IL_RS00575	COG4558	Periplasmic binding protein
IL_RS00580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IL_RS00585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IL_RS00620	COG0415	Belongs to the DNA photolyase family
IL_RS00625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IL_RS00645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IL_RS00650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IL_RS00665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IL_RS00670	COG0463	Glycosyl transferase, family 2
IL_RS00680	COG2986	histidine ammonia-lyase
IL_RS00710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IL_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
IL_RS00735	COG1505	serine-type exopeptidase activity
IL_RS00745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IL_RS00750	COG2166	iron-sulfur cluster assembly
IL_RS00765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IL_RS00770	COG0719	Fe-S assembly protein
IL_RS00775	COG0396	ATPase activity
IL_RS00780	COG0719	Fe-S assembly protein
IL_RS00785	COG2197	response regulator
IL_RS00790	COG1462	curli production assembly transport component CsgG
IL_RS00820	COG1404	Belongs to the peptidase S8 family
IL_RS00830	COG0217	transcriptional regulatory protein
IL_RS00835	COG3047	cAMP biosynthetic process
IL_RS00880	COG0813	purine-nucleoside phosphorylase activity
IL_RS00890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IL_RS00900	COG1960	acyl-CoA dehydrogenase activity
IL_RS00910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IL_RS00915	COG0826	peptidase U32
IL_RS00920	COG2197	response regulator
IL_RS00930	COG3850	Histidine kinase
IL_RS00960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IL_RS00965	COG3154	lipid carrier protein
IL_RS00970	COG0826	peptidase U32
IL_RS00975	COG0826	peptidase U32
IL_RS00985	COG2832	Protein of unknown function (DUF454)
IL_RS00990	COG3604	Transcriptional regulator
IL_RS01010	COG0569	domain protein
IL_RS01015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IL_RS01030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IL_RS01085	COG0606	chelatase, subunit chli
IL_RS01100	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IL_RS01110	COG0626	cystathionine gamma-synthase activity
IL_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IL_RS01130	COG3068	Protein conserved in bacteria
IL_RS01140	COG0742	ribosomal rna small subunit methyltransferase
IL_RS01145	COG0552	protein localization to endoplasmic reticulum
IL_RS01150	COG2884	Cell division ATP-binding protein ftsE
IL_RS01155	COG2177	Part of the ABC transporter FtsEX involved in
IL_RS01160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IL_RS01165	COG2861	carbohydrate metabolic process
IL_RS01170	COG4942	peptidase
IL_RS01175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IL_RS01180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IL_RS01185	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IL_RS01190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IL_RS01195	COG1309	transcriptional regulator
IL_RS01200	COG0756	dUTP diphosphatase activity
IL_RS01205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IL_RS01210	COG2003	Belongs to the UPF0758 family
IL_RS01215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IL_RS01220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IL_RS01235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IL_RS01240	COG0596	Alpha beta hydrolase
IL_RS01250	COG0316	Belongs to the HesB IscA family
IL_RS01250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IL_RS01260	COG0534	Mate efflux family protein
IL_RS01265	COG0726	polysaccharide deacetylase
IL_RS01275	COG0109	protoheme IX farnesyltransferase activity
IL_RS01280	COG1612	heme a metabolic process
IL_RS01315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IL_RS01325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IL_RS01335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IL_RS01340	COG3161	chorismate lyase activity
IL_RS01350	COG0705	Rhomboid family
IL_RS01355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IL_RS01360	COG1063	alcohol dehydrogenase
IL_RS01365	COG0156	8-amino-7-oxononanoate synthase activity
IL_RS01370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IL_RS01375	COG0733	neurotransmitter:sodium symporter activity
IL_RS01380	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IL_RS01385	COG4152	abc transporter atp-binding protein
IL_RS01395	COG1506	peptidase
IL_RS01395	COG4946	Tricorn protease homolog
IL_RS01395	COG0823	Involved in the tonB-independent uptake of proteins
IL_RS01420	COG2183	response to ionizing radiation
IL_RS01425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IL_RS01440	COG2161	toxin-antitoxin pair type II binding
IL_RS01445	COG4115	mRNA cleavage
IL_RS01480	COG1597	lipid kinase activity
IL_RS01495	COG3279	Response regulator of the LytR AlgR family
IL_RS01505	COG3706	GGDEF domain
IL_RS01515	COG0095	Lipoate-protein ligase
IL_RS01540	COG1051	belongs to the nudix hydrolase family
IL_RS01545	COG2186	Transcriptional regulator
IL_RS01555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IL_RS01565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IL_RS01575	COG1131	(ABC) transporter
IL_RS01580	COG4585	Histidine kinase
IL_RS01585	COG2197	response regulator
IL_RS01590	COG2130	NADP-dependent
IL_RS01625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IL_RS01630	COG0494	nUDIX hydrolase
IL_RS01635	COG1218	3'(2'),5'-bisphosphate nucleotidase
IL_RS01640	COG3089	Belongs to the UPF0270 family
IL_RS01645	COG0488	(ABC) transporter
IL_RS01650	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IL_RS01655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IL_RS01655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IL_RS01660	COG0802	atpase or kinase
IL_RS01670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IL_RS01675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IL_RS01680	COG1923	regulation of RNA biosynthetic process
IL_RS01685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IL_RS01690	COG0330	HflC and HflK could
IL_RS01695	COG0330	HflC and HflK could
IL_RS01700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IL_RS01725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IL_RS01735	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IL_RS01740	COG0250	Participates in transcription elongation, termination and antitermination
IL_RS01745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IL_RS01750	COG0081	regulation of translation
IL_RS01755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IL_RS01760	COG0222	ribosome binding
IL_RS01765	COG0085	RNA polymerase activity
IL_RS01770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IL_RS01775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IL_RS01780	COG0049	tRNA binding
IL_RS01785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IL_RS01790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IL_RS01810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IL_RS01815	COG2814	Major facilitator Superfamily
IL_RS01820	COG0629	single-stranded DNA binding
IL_RS01830	COG1566	PFAM secretion protein HlyD family protein
IL_RS01840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IL_RS01845	COG1435	thymidine kinase activity
IL_RS01850	COG0418	dihydroorotase activity
IL_RS01880	COG3267	Type II secretory pathway component ExeA
IL_RS01880	COG3409	Peptidoglycan-binding domain 1 protein
IL_RS01890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IL_RS01895	COG1459	type II secretion system
IL_RS01905	COG2165	general secretion pathway protein
IL_RS01940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IL_RS01945	COG1077	Cell shape determining protein MreB Mrl
IL_RS01950	COG1792	Involved in formation and maintenance of cell shape
IL_RS01955	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IL_RS01960	COG0424	maF-like protein
IL_RS01965	COG1530	ribonuclease E activity
IL_RS01975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IL_RS01980	COG0312	modulator of DNA gyrase
IL_RS01985	COG3028	Belongs to the UPF0307 family
IL_RS01990	COG0312	modulator of DNA gyrase
IL_RS01995	COG2239	Acts as a magnesium transporter
IL_RS02000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IL_RS02005	COG1660	Displays ATPase and GTPase activities
IL_RS02010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IL_RS02020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IL_RS02025	COG1137	ATPase activity
IL_RS02030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IL_RS02040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IL_RS02045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IL_RS02045	COG0517	IMP dehydrogenase activity
IL_RS02055	COG1127	ABC transporter
IL_RS02060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IL_RS02065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IL_RS02070	COG2854	intermembrane phospholipid transfer
IL_RS02080	COG5007	Belongs to the BolA IbaG family
IL_RS02085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IL_RS02090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IL_RS02095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IL_RS02105	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IL_RS02110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IL_RS02115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IL_RS02120	COG0723	plastoquinol--plastocyanin reductase activity
IL_RS02125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IL_RS02130	COG2857	Cytochrome c1
IL_RS02135	COG0625	glutathione transferase activity
IL_RS02140	COG2969	positive regulation of protein catabolic process
IL_RS02145	COG2823	Periplasmic or secreted lipoprotein
IL_RS02155	COG0792	nuclease activity
IL_RS02160	COG3107	peptidoglycan biosynthetic process
IL_RS02165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IL_RS02175	COG2001	Belongs to the MraZ family
IL_RS02180	COG0275	rRNA processing
IL_RS02185	COG3116	cell division
IL_RS02190	COG0768	penicillin binding
IL_RS02200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IL_RS02205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IL_RS02210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IL_RS02215	COG0772	Belongs to the SEDS family
IL_RS02220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IL_RS02225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IL_RS02230	COG1181	Belongs to the D-alanine--D-alanine ligase family
IL_RS02240	COG0849	cell division
IL_RS02250	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IL_RS02260	COG0739	heme binding
IL_RS02265	COG0653	protein targeting
IL_RS02270	COG0494	nUDIX hydrolase
IL_RS02275	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IL_RS02280	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IL_RS02285	COG0237	dephospho-CoA kinase activity
IL_RS02295	COG1459	type II secretion system
IL_RS02300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IL_RS02310	COG0157	Belongs to the NadC ModD family
IL_RS02320	COG3725	Membrane protein required for beta-lactamase induction
IL_RS02325	COG2186	Transcriptional regulator
IL_RS02330	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IL_RS02335	COG0508	dehydrogenase complex catalyzes the overall conversion of
IL_RS02340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IL_RS02345	COG3590	peptidase
IL_RS02355	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IL_RS02385	COG2837	iron assimilation
IL_RS02390	COG1438	arginine binding
IL_RS02395	COG0039	L-malate dehydrogenase activity
IL_RS02405	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS02410	COG0142	geranyltranstransferase activity
IL_RS02415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IL_RS02420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IL_RS02425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IL_RS02430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IL_RS02445	COG4555	ABC transporter
IL_RS02450	COG1668	transmembrane transport
IL_RS02455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IL_RS02465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IL_RS02470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IL_RS02485	COG1469	GTP cyclohydrolase I activity
IL_RS02495	COG0745	RESPONSE REGULATOR receiver
IL_RS02500	COG4191	Histidine kinase
IL_RS02505	COG2813	Specifically methylates the guanine in position
IL_RS02525	COG0189	ligase activity
IL_RS02530	COG0189	ligase activity
IL_RS02530	COG4067	protein conserved in archaea
IL_RS02535	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS02540	COG2199	diguanylate cyclase activity
IL_RS02540	COG2200	EAL domain
IL_RS02540	COG3287	FIST C domain
IL_RS02555	COG1051	belongs to the nudix hydrolase family
IL_RS02560	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IL_RS02565	COG0730	response to heat
IL_RS02570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IL_RS02575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IL_RS02580	COG1943	Transposase
IL_RS02600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IL_RS02605	COG2166	iron-sulfur cluster assembly
IL_RS02625	COG0823	Involved in the tonB-independent uptake of proteins
IL_RS02625	COG1506	peptidase
IL_RS02625	COG4946	Tricorn protease homolog
IL_RS02635	COG2089	acid synthase
IL_RS02650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IL_RS02655	COG0583	DNA-binding transcription factor activity
IL_RS02660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IL_RS02665	COG3002	Belongs to the UPF0753 family
IL_RS02690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IL_RS02710	COG1160	GTP binding
IL_RS02720	COG4735	regulation of single-species biofilm formation
IL_RS02725	COG3604	Transcriptional regulator
IL_RS02740	COG1132	(ABC) transporter
IL_RS02750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IL_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
IL_RS02765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IL_RS02775	COG0110	maltose O-acetyltransferase activity
IL_RS02780	COG1086	Polysaccharide biosynthesis protein
IL_RS02785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IL_RS02790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IL_RS02795	COG2089	acid synthase
IL_RS02810	COG1083	cytidylyl-transferase
IL_RS02820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IL_RS02825	COG1216	Glycosyl transferase, family 2
IL_RS02825	COG0463	Glycosyl transferase, family 2
IL_RS02830	COG0438	transferase activity, transferring glycosyl groups
IL_RS02835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IL_RS02880	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IL_RS02890	COG0166	Belongs to the GPI family
IL_RS02905	COG1218	3'(2'),5'-bisphosphate nucleotidase
IL_RS02910	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS02930	COG0517	IMP dehydrogenase activity
IL_RS02930	COG0516	GMP reductase activity
IL_RS02935	COG0519	Catalyzes the synthesis of GMP from XMP
IL_RS02935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IL_RS02960	COG1757	Na H antiporter
IL_RS02970	COG1473	amidohydrolase
IL_RS02975	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IL_RS02980	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS02995	COG0047	phosphoribosylformylglycinamidine synthase activity
IL_RS02995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IL_RS03005	COG3657	addiction module killer protein
IL_RS03010	COG1234	tRNA 3'-trailer cleavage
IL_RS03025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IL_RS03030	COG0281	malic enzyme
IL_RS03050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IL_RS03060	COG4191	Histidine kinase
IL_RS03060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IL_RS03065	COG1506	peptidase
IL_RS03065	COG0823	Involved in the tonB-independent uptake of proteins
IL_RS03065	COG4946	Tricorn protease homolog
IL_RS03075	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IL_RS03080	COG2224	Isocitrate lyase
IL_RS03085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IL_RS03100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IL_RS03115	COG0137	argininosuccinate synthase activity
IL_RS03120	COG0165	Argininosuccinate lyase
IL_RS03120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IL_RS03125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IL_RS03145	COG3264	Mechanosensitive ion channel
IL_RS03145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IL_RS03150	COG0488	(ABC) transporter
IL_RS03155	COG0625	glutathione transferase activity
IL_RS03170	COG2855	membrane
IL_RS03185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IL_RS03195	COG0789	Transcriptional regulator
IL_RS03220	COG2003	Belongs to the UPF0758 family
IL_RS03230	COG2003	Belongs to the UPF0758 family
IL_RS03250	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IL_RS03270	COG0582	viral genome integration into host DNA
IL_RS03295	COG0582	viral genome integration into host DNA
IL_RS03315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IL_RS03320	COG0322	excinuclease ABC activity
IL_RS03350	COG0670	Belongs to the BI1 family
IL_RS03375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IL_RS03380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IL_RS03385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IL_RS03390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IL_RS03395	COG1674	ftsk spoiiie
IL_RS03395	COG0531	amino acid
IL_RS03405	COG0686	Belongs to the AlaDH PNT family
IL_RS03410	COG0492	ferredoxin-NADP+ reductase activity
IL_RS03415	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IL_RS03420	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IL_RS03425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IL_RS03430	COG0542	response to heat
IL_RS03435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IL_RS03440	COG1278	Cold shock
IL_RS03445	COG3081	Nucleoid-associated protein
IL_RS03450	COG3083	sulfuric ester hydrolase activity
IL_RS03515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IL_RS03520	COG4221	oxidoreductase activity
IL_RS03525	COG1309	transcriptional regulator
IL_RS03530	COG2502	aspartate--ammonia ligase
IL_RS03535	COG1522	sequence-specific DNA binding
IL_RS03550	COG1966	Carbon starvation protein
IL_RS03560	COG0003	Pfam Anion-transporting ATPase
IL_RS03565	COG0604	alcohol dehydrogenase
IL_RS03570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IL_RS03575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IL_RS03600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IL_RS03610	COG0717	Belongs to the dCTP deaminase family
IL_RS03615	COG0489	protein tyrosine kinase activity
IL_RS03620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IL_RS03620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IL_RS03635	COG0537	adenosine 5'-monophosphoramidase activity
IL_RS03645	COG0405	Gamma-glutamyltransferase
IL_RS03660	COG0625	glutathione transferase activity
IL_RS03670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IL_RS03685	COG2154	pterin-4-alpha-carbinolamine dehydratase
IL_RS03705	COG3106	COG3106 Predicted ATPase
IL_RS03720	COG1842	Phage shock protein A
IL_RS03725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IL_RS03730	COG0747	negative chemotaxis
IL_RS03735	COG4168	peptide transport system, permease
IL_RS03740	COG4171	peptide transport system, permease
IL_RS03750	COG4172	Belongs to the ABC transporter superfamily
IL_RS03755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IL_RS03760	COG0405	Gamma-glutamyltransferase
IL_RS03765	COG1752	Esterase of the alpha-beta hydrolase superfamily
IL_RS03770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IL_RS03775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IL_RS03785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IL_RS03790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IL_RS03795	COG1388	LysM domain
IL_RS03795	COG4942	peptidase
IL_RS03800	COG1238	metal cluster binding
IL_RS03805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IL_RS03810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IL_RS03815	COG0585	pseudouridine synthase activity
IL_RS03820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IL_RS03825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IL_RS03830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IL_RS03840	COG5001	Diguanylate cyclase
IL_RS03840	COG3300	MHYT domain
IL_RS03845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IL_RS03860	COG3128	pkhd-type hydroxylase
IL_RS03870	COG2010	Cytochrome c
IL_RS03890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IL_RS03900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IL_RS03905	COG2104	thiamine diphosphate biosynthetic process
IL_RS03910	COG2022	thiamine diphosphate biosynthetic process
IL_RS03925	COG0148	phosphopyruvate hydratase activity
IL_RS03930	COG0504	CTP synthase activity
IL_RS04010	COG0662	Cupin 2, conserved barrel domain protein
IL_RS04045	COG1454	alcohol dehydrogenase
IL_RS04055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IL_RS04090	COG3956	TIGRFAM MazG family protein
IL_RS04095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IL_RS04100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IL_RS04105	COG0736	holo-[acyl-carrier-protein] synthase activity
IL_RS04110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IL_RS04115	COG1381	Involved in DNA repair and RecF pathway recombination
IL_RS04120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IL_RS04125	COG0571	ribonuclease III activity
IL_RS04135	COG0481	GTPase activity
IL_RS04140	COG3086	response to oxidative stress
IL_RS04155	COG1595	DNA-templated transcription, initiation
IL_RS04160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IL_RS04170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IL_RS04185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IL_RS04190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IL_RS04195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IL_RS04200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IL_RS04205	COG4974	Belongs to the 'phage' integrase family
IL_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
IL_RS04220	COG3321	synthase
IL_RS04220	COG0604	alcohol dehydrogenase
IL_RS04235	COG0435	Glutathione S-transferase
IL_RS04240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IL_RS04245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IL_RS04250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IL_RS04255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IL_RS04270	COG0750	zinc metalloprotease
IL_RS04275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IL_RS04280	COG0575	Belongs to the CDS family
IL_RS04285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IL_RS04290	COG0233	cytoplasmic translational termination
IL_RS04295	COG0528	UMP kinase activity
IL_RS04300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IL_RS04305	COG0052	Belongs to the universal ribosomal protein uS2 family
IL_RS04310	COG0024	Methionine aminopeptidase
IL_RS04315	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IL_RS04320	COG2171	N-acyltransferase activity
IL_RS04330	COG3098	single-species biofilm formation
IL_RS04355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IL_RS04355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IL_RS04370	COG1611	Belongs to the LOG family
IL_RS04385	COG0473	3-isopropylmalate dehydrogenase activity
IL_RS04390	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IL_RS04395	COG2363	Small membrane protein
IL_RS04405	COG0583	DNA-binding transcription factor activity
IL_RS04410	COG1028	Short-chain dehydrogenase reductase Sdr
IL_RS04420	COG1024	Enoyl-CoA hydratase
IL_RS04420	COG1250	3-hydroxyacyl-CoA dehydrogenase
IL_RS04425	COG1960	acyl-CoA dehydrogenase activity
IL_RS04435	COG0697	spore germination
IL_RS04440	COG0183	Belongs to the thiolase family
IL_RS04450	COG1960	acyl-CoA dehydrogenase activity
IL_RS04455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IL_RS04460	COG1024	Enoyl-CoA hydratase
IL_RS04465	COG4770	biotin carboxylase activity
IL_RS04475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IL_RS04480	COG5001	Diguanylate cyclase
IL_RS04480	COG3300	MHYT domain
IL_RS04490	COG2916	Histone family protein nucleoid-structuring protein H-NS
IL_RS04505	COG1720	tRNA m6t6A37 methyltransferase activity
IL_RS04510	COG0442	prolyl-tRNA aminoacylation
IL_RS04515	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IL_RS04530	COG3101	peptidyl-lysine hydroxylation
IL_RS04535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IL_RS04550	COG2062	phosphohistidine phosphatase, SixA
IL_RS04555	COG2914	Belongs to the UPF0125 (RnfH) family
IL_RS04560	COG2867	negative regulation of translational initiation
IL_RS04565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IL_RS04590	COG4964	Belongs to the GSP D family
IL_RS04640	COG0602	queuosine metabolic process
IL_RS04645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IL_RS04650	COG1472	Belongs to the glycosyl hydrolase 3 family
IL_RS04655	COG3409	Peptidoglycan-binding domain 1 protein
IL_RS04655	COG0793	Belongs to the peptidase S41A family
IL_RS04660	COG1960	acyl-CoA dehydrogenase activity
IL_RS04670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IL_RS04675	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IL_RS04690	COG3437	response regulator, receiver
IL_RS04690	COG0784	Response regulator, receiver
IL_RS04695	COG2890	protein-(glutamine-N5) methyltransferase activity
IL_RS04700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IL_RS04705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IL_RS04710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IL_RS04715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IL_RS04720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IL_RS04725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IL_RS04730	COG0193	aminoacyl-tRNA hydrolase activity
IL_RS04735	COG0012	GTP binding
IL_RS04795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IL_RS04805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IL_RS04810	COG1702	phosphate starvation-inducible protein PhoH
IL_RS04815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IL_RS04820	COG4535	Mg2 and Co2 transporter CorC
IL_RS04825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IL_RS04835	COG0495	leucyl-tRNA aminoacylation
IL_RS04840	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IL_RS04850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IL_RS04855	COG0799	negative regulation of ribosome biogenesis
IL_RS04860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IL_RS04865	COG0768	penicillin binding
IL_RS04870	COG0772	Belongs to the SEDS family
IL_RS04875	COG2951	lytic endotransglycosylase activity
IL_RS04880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IL_RS04885	COG1686	Belongs to the peptidase S11 family
IL_RS04890	COG2921	Belongs to the UPF0250 family
IL_RS04895	COG0321	lipoyl(octanoyl) transferase activity
IL_RS04900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IL_RS04920	COG1185	polyribonucleotide nucleotidyltransferase activity
IL_RS04925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IL_RS04930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IL_RS04935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IL_RS04940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IL_RS04945	COG0195	Participates in both transcription termination and antitermination
IL_RS04950	COG0779	Required for maturation of 30S ribosomal subunits
IL_RS04965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IL_RS04970	COG0149	triose-phosphate isomerase activity
IL_RS04975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IL_RS04980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IL_RS04985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IL_RS04990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IL_RS04995	COG1534	Rna-binding protein
IL_RS05005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IL_RS05010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IL_RS05015	COG0505	Belongs to the CarA family
IL_RS05020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IL_RS05025	COG1301	dicarboxylic acid transport
IL_RS05030	COG4783	chaperone-mediated protein folding
IL_RS05035	COG0484	heat shock protein binding
IL_RS05040	COG0443	Heat shock 70 kDa protein
IL_RS05045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IL_RS05050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IL_RS05055	COG0497	DNA recombination
IL_RS05060	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IL_RS05065	COG1025	Belongs to the peptidase M16 family
IL_RS05075	COG1250	3-hydroxyacyl-CoA dehydrogenase
IL_RS05075	COG1024	Enoyl-CoA hydratase
IL_RS05080	COG0183	Belongs to the thiolase family
IL_RS05085	COG0714	Associated with various cellular activities
IL_RS05100	COG2304	oxidoreductase activity
IL_RS05105	COG2304	oxidoreductase activity
IL_RS05115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IL_RS05120	COG0776	regulation of translation
IL_RS05125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IL_RS05130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IL_RS05135	COG0740	serine-type endopeptidase activity
IL_RS05140	COG0544	peptidyl-prolyl cis-trans isomerase activity
IL_RS05170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IL_RS05185	COG3724	N-succinylarginine dihydrolase activity
IL_RS05190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IL_RS05195	COG1286	toxin biosynthetic process
IL_RS05200	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IL_RS05205	COG0285	dihydrofolate synthase activity
IL_RS05210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IL_RS05215	COG0101	tRNA pseudouridine synthase activity
IL_RS05230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IL_RS05235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IL_RS05240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IL_RS05240	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IL_RS05250	COG0716	FMN binding
IL_RS05260	COG1607	acyl-coa hydrolase
IL_RS05285	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IL_RS05290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IL_RS05295	COG0215	cysteine-tRNA ligase activity
IL_RS05300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IL_RS05315	COG1301	dicarboxylic acid transport
IL_RS05320	COG0616	signal peptide processing
IL_RS05325	COG2267	carboxylic ester hydrolase activity
IL_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
IL_RS05340	COG1104	cysteine desulfurase activity
IL_RS05350	COG1477	protein flavinylation
IL_RS05355	COG2871	sodium ion transport
IL_RS05360	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IL_RS05365	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IL_RS05370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IL_RS05375	COG1805	sodium ion transport
IL_RS05380	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IL_RS05385	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IL_RS05390	COG0271	Belongs to the BolA IbaG family
IL_RS05410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IL_RS05410	COG3008	intermembrane lipid transfer
IL_RS05415	COG2995	paraquat-inducible protein a
IL_RS05425	COG1840	ABC-type Fe3 transport system, periplasmic component
IL_RS05435	COG3842	ATPase activity
IL_RS05460	COG2193	ferroxidase activity
IL_RS05475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IL_RS05500	COG0493	'glutamate synthase
IL_RS05505	COG0070	glutamate synthase
IL_RS05505	COG0069	glutamate synthase activity
IL_RS05505	COG0067	glutamate synthase
IL_RS05510	COG3385	transposase activity
IL_RS05530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IL_RS05535	COG2885	chlorophyll binding
IL_RS05540	COG0823	Involved in the tonB-independent uptake of proteins
IL_RS05555	COG0811	peptide transport
IL_RS05560	COG0824	Thioesterase
IL_RS05565	COG2255	four-way junction helicase activity
IL_RS05570	COG0632	four-way junction helicase activity
IL_RS05575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IL_RS05580	COG0217	transcriptional regulatory protein
IL_RS05585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IL_RS05595	COG2226	methyltransferase
IL_RS05600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IL_RS05605	COG0583	DNA-binding transcription factor activity
IL_RS05610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IL_RS05620	COG0745	RESPONSE REGULATOR receiver
IL_RS05625	COG2853	Lipoprotein
IL_RS05640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IL_RS05645	COG1138	Cytochrome C-type biogenesis protein
IL_RS05650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IL_RS05660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IL_RS05665	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IL_RS05670	COG4133	protoheme IX ABC transporter activity
IL_RS05690	COG0835	chemotaxis
IL_RS05700	COG1192	Involved in chromosome partitioning
IL_RS05705	COG2201	protein-glutamate methylesterase activity
IL_RS05710	COG0784	Response regulator, receiver
IL_RS05710	COG0643	Histidine kinase
IL_RS05710	COG2198	Histidine kinase
IL_RS05715	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IL_RS05740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IL_RS05765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IL_RS05770	COG1047	Peptidyl-prolyl cis-trans
IL_RS05775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IL_RS05780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IL_RS05785	COG0196	riboflavin kinase activity
IL_RS05790	COG0728	peptidoglycan biosynthetic process
IL_RS05795	COG0268	Binds directly to 16S ribosomal RNA
IL_RS05810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IL_RS05830	COG4786	Flagellar basal body rod
IL_RS05830	COG1256	bacterial-type flagellum assembly
IL_RS05835	COG3951	Flagellar rod assembly protein muramidase FlgJ
IL_RS05835	COG1705	Flagellar rod assembly protein muramidase FlgJ
IL_RS05840	COG1706	bacterial-type flagellum-dependent cell motility
IL_RS05845	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IL_RS05850	COG4786	Flagellar basal body rod
IL_RS05855	COG4787	bacterial-type flagellum-dependent cell motility
IL_RS05865	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IL_RS05875	COG1815	bacterial-type flagellum-dependent cell motility
IL_RS05880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IL_RS05885	COG0835	chemotaxis
IL_RS05885	COG0784	Response regulator, receiver
IL_RS05925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IL_RS05930	COG4136	ATPase activity
IL_RS05935	COG4135	transport system, permease component
IL_RS05945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IL_RS05965	COG2207	Transcriptional regulator
IL_RS06010	COG4206	TonB-dependent receptor
IL_RS06020	COG4206	TonB-dependent receptor
IL_RS06030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IL_RS06030	COG0517	IMP dehydrogenase activity
IL_RS06035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IL_RS06070	COG1183	phosphatidylcholine synthase activity
IL_RS06075	COG0542	response to heat
IL_RS06085	COG0564	pseudouridine synthase activity
IL_RS06100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IL_RS06100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IL_RS06115	COG1987	bacterial-type flagellum assembly
IL_RS06155	COG1157	protein secretion by the type III secretion system
IL_RS06165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IL_RS06170	COG1766	The M ring may be actively involved in energy transduction
IL_RS06200	COG2197	response regulator
IL_RS06205	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IL_RS06210	COG3437	response regulator, receiver
IL_RS06210	COG0784	Response regulator, receiver
IL_RS06215	COG0259	pyridoxamine-phosphate oxidase activity
IL_RS06225	COG0205	6-phosphofructokinase activity
IL_RS06230	COG0010	Belongs to the arginase family
IL_RS06235	COG1166	arginine decarboxylase activity
IL_RS06245	COG2801	Transposase and inactivated derivatives
IL_RS06270	COG2217	Heavy metal translocating P-type atpase
IL_RS06290	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IL_RS06305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IL_RS06325	COG0531	amino acid
IL_RS06350	COG2132	Multicopper oxidase
IL_RS06355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IL_RS06390	COG0789	Transcriptional regulator
IL_RS06420	COG3145	DNA-N1-methyladenine dioxygenase activity
IL_RS06445	COG0583	DNA-binding transcription factor activity
IL_RS06475	COG2972	Histidine kinase
IL_RS06480	COG3279	Response regulator of the LytR AlgR family
IL_RS06490	COG0469	pyruvate kinase activity
IL_RS06495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IL_RS06510	COG2866	Carboxypeptidase
IL_RS06515	COG1115	amino acid carrier protein
IL_RS06525	COG3139	Protein of unknown function (DUF1315)
IL_RS06530	COG1956	GAF domain-containing protein
IL_RS06540	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IL_RS06545	COG0793	Belongs to the peptidase S41A family
IL_RS06550	COG0733	neurotransmitter:sodium symporter activity
IL_RS06555	COG1757	Na H antiporter
IL_RS06560	COG0308	aminopeptidase N
IL_RS06570	COG2902	Dehydrogenase
IL_RS06575	COG0167	dihydroorotate dehydrogenase activity
IL_RS06590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IL_RS06590	COG0116	Belongs to the methyltransferase superfamily
IL_RS06600	COG0488	(ABC) transporter
IL_RS06610	COG3130	regulation of translation
IL_RS06615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IL_RS06620	COG1067	ATP-dependent peptidase activity
IL_RS06640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IL_RS06655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IL_RS06660	COG0840	transmembrane signaling receptor activity
IL_RS06665	COG3278	Belongs to the heme-copper respiratory oxidase family
IL_RS06680	COG2010	Cytochrome c
IL_RS06690	COG2217	Heavy metal translocating P-type atpase
IL_RS06705	COG0589	response to stress
IL_RS06710	COG0037	tRNA processing
IL_RS06730	COG0482	sulfurtransferase activity
IL_RS06735	COG2915	High frequency lysogenization protein hflD homolog
IL_RS06740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IL_RS06745	COG2850	peptidyl-arginine hydroxylation
IL_RS06755	COG0277	FAD linked oxidase domain protein
IL_RS06755	COG0247	lactate metabolic process
IL_RS06760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IL_RS06760	COG0574	Belongs to the PEP-utilizing enzyme family
IL_RS06765	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IL_RS06775	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IL_RS06780	COG0501	Belongs to the peptidase M48B family
IL_RS06785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IL_RS06790	COG2226	methyltransferase
IL_RS06800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IL_RS06805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IL_RS06815	COG0017	Asparaginyl-tRNA synthetase
IL_RS06825	COG0616	signal peptide processing
IL_RS06830	COG0252	asparaginase activity
IL_RS06835	COG0733	neurotransmitter:sodium symporter activity
IL_RS06840	COG2079	MmgE PrpD family protein
IL_RS06845	COG0084	hydrolase, TatD family'
IL_RS06855	COG0470	DNA polymerase III
IL_RS06860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IL_RS06865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IL_RS06870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IL_RS06875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IL_RS06885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IL_RS06895	COG0416	fatty acid biosynthetic process
IL_RS06900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IL_RS06905	COG1399	metal-binding, possibly nucleic acid-binding protein
IL_RS06910	COG0424	maF-like protein
IL_RS06920	COG0564	pseudouridine synthase activity
IL_RS06925	COG1530	ribonuclease E activity
IL_RS06935	COG0284	orotidine-5'-phosphate decarboxylase activity
IL_RS06940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IL_RS06950	COG0776	regulation of translation
IL_RS06955	COG0539	negative regulation of cytoplasmic translation
IL_RS06960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IL_RS06965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IL_RS06970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IL_RS06975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IL_RS06985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IL_RS06995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IL_RS07000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IL_RS07010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IL_RS07015	COG1643	Atp-dependent helicase
IL_RS07020	COG1446	asparaginase
IL_RS07030	COG2925	Exonuclease
IL_RS07055	COG2084	Dehydrogenase
IL_RS07060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IL_RS07065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IL_RS07095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IL_RS07105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IL_RS07110	COG4221	oxidoreductase activity
IL_RS07120	COG0415	Belongs to the DNA photolyase family
IL_RS07125	COG3272	Protein of unknown function (DUF1722)
IL_RS07135	COG1595	DNA-templated transcription, initiation
IL_RS07145	COG0776	regulation of translation
IL_RS07150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IL_RS07150	COG0072	phenylalanine-tRNA ligase activity
IL_RS07155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IL_RS07160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IL_RS07165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IL_RS07170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IL_RS07175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IL_RS07190	COG0307	riboflavin synthase, alpha
IL_RS07220	COG1012	belongs to the aldehyde dehydrogenase family
IL_RS07230	COG0659	secondary active sulfate transmembrane transporter activity
IL_RS07235	COG1454	alcohol dehydrogenase
IL_RS07250	COG0513	Belongs to the DEAD box helicase family
IL_RS07255	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IL_RS07275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IL_RS07280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IL_RS07290	COG0840	transmembrane signaling receptor activity
IL_RS07310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IL_RS07315	COG0372	Belongs to the citrate synthase family
IL_RS07320	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IL_RS07330	COG0861	Integral membrane protein TerC family
IL_RS07355	COG0346	lactoylglutathione lyase activity
IL_RS07370	COG1968	undecaprenyl-diphosphatase activity
IL_RS07380	COG0527	aspartate kinase activity
IL_RS07385	COG1064	alcohol dehydrogenase
IL_RS07405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IL_RS07420	COG0784	Response regulator, receiver
IL_RS07420	COG5002	protein histidine kinase activity
IL_RS07440	COG0708	Exodeoxyribonuclease III
IL_RS07445	COG3092	negative regulation of chromosome organization
IL_RS07455	COG1393	Belongs to the ArsC family
IL_RS07460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IL_RS07465	COG1876	peptidase activity
IL_RS07475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IL_RS07480	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IL_RS07485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IL_RS07490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IL_RS07500	COG4783	chaperone-mediated protein folding
IL_RS07510	COG1393	Belongs to the ArsC family
IL_RS07540	COG0033	Phosphoglucomutase
IL_RS07545	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IL_RS07550	COG0596	Alpha beta hydrolase
IL_RS07560	COG0716	FMN binding
IL_RS07575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IL_RS07580	COG1984	allophanate hydrolase subunit 2
IL_RS07645	COG0513	Belongs to the DEAD box helicase family
IL_RS07655	COG3300	MHYT domain
IL_RS07655	COG5001	Diguanylate cyclase
IL_RS07680	COG0783	Belongs to the Dps family
IL_RS07685	COG3385	transposase activity
IL_RS07695	COG0045	succinate-CoA ligase (ADP-forming) activity
IL_RS07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
IL_RS07705	COG0567	Dehydrogenase, E1 component
IL_RS07715	COG1053	succinate dehydrogenase
IL_RS07720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IL_RS07730	COG0372	Belongs to the citrate synthase family
IL_RS07735	COG1509	lysine 2,3-aminomutase activity
IL_RS07740	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IL_RS07745	COG2835	tetraacyldisaccharide 4'-kinase activity
IL_RS07750	COG1663	tetraacyldisaccharide 4'-kinase activity
IL_RS07755	COG1132	(ABC) transporter
IL_RS07760	COG0658	competence protein
IL_RS07760	COG2333	competence protein COMEC
IL_RS07770	COG4591	ABC-type transport system involved in lipoprotein release permease component
IL_RS07775	COG1136	(ABC) transporter
IL_RS07780	COG4591	ABC-type transport system involved in lipoprotein release permease component
IL_RS07790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IL_RS07810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IL_RS07810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IL_RS07815	COG0367	asparagine synthase
IL_RS07820	COG0540	Belongs to the ATCase OTCase family
IL_RS07825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IL_RS07845	COG3385	transposase activity
IL_RS07855	COG1946	Acyl-CoA thioesterase
IL_RS07860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IL_RS07865	COG0572	uridine kinase
IL_RS07870	COG0612	Peptidase, M16
IL_RS07880	COG2200	EAL domain
IL_RS07880	COG2199	diguanylate cyclase activity
IL_RS07880	COG3287	FIST C domain
IL_RS07890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IL_RS07895	COG1960	acyl-CoA dehydrogenase activity
IL_RS07905	COG5001	Diguanylate cyclase
IL_RS07905	COG3300	MHYT domain
IL_RS07915	COG0513	Belongs to the DEAD box helicase family
IL_RS07925	COG3141	response to X-ray
IL_RS07930	COG2814	Major facilitator Superfamily
IL_RS07965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IL_RS07990	COG2823	Periplasmic or secreted lipoprotein
IL_RS08010	COG3047	cAMP biosynthetic process
IL_RS08010	COG2885	chlorophyll binding
IL_RS08015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IL_RS08020	COG1704	LemA family
IL_RS08030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IL_RS08050	COG3135	benzoate transporter
IL_RS08055	COG3739	integral membrane protein
IL_RS08090	COG4773	Receptor
IL_RS08175	COG3038	cytochrome b561
IL_RS08180	COG0604	alcohol dehydrogenase
IL_RS08185	COG4716	Myosin-crossreactive antigen
IL_RS08190	COG0251	oxidation-reduction process
IL_RS08210	COG0596	Alpha beta hydrolase
IL_RS08220	COG2814	Major facilitator Superfamily
IL_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
IL_RS08235	COG0583	DNA-binding transcription factor activity
IL_RS08240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IL_RS08245	COG0583	DNA-binding transcription factor activity
IL_RS08270	COG2801	Transposase and inactivated derivatives
IL_RS08285	COG0653	protein targeting
IL_RS08300	COG3384	dioxygenase
IL_RS08315	COG2963	transposase activity
IL_RS08320	COG2801	Transposase and inactivated derivatives
IL_RS08335	COG0582	viral genome integration into host DNA
IL_RS08395	COG1742	UPF0060 membrane protein
IL_RS08400	COG0789	Transcriptional regulator
IL_RS08405	COG2608	mercury ion transmembrane transporter activity
IL_RS08440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IL_RS08445	COG1368	sulfuric ester hydrolase activity
IL_RS08455	COG0582	viral genome integration into host DNA
IL_RS08460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IL_RS08465	COG1902	pentaerythritol trinitrate reductase activity
IL_RS08475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IL_RS08480	COG2205	protein histidine kinase activity
IL_RS08485	COG0745	RESPONSE REGULATOR receiver
IL_RS08490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IL_RS08495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IL_RS08500	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS08515	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IL_RS08520	COG2814	Major facilitator Superfamily
IL_RS08525	COG0737	Belongs to the 5'-nucleotidase family
IL_RS08535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IL_RS08540	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IL_RS08545	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IL_RS08580	COG0022	dehydrogenase e1 component
IL_RS08585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IL_RS08590	COG2988	succinylglutamate desuccinylase activity
IL_RS08605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IL_RS08615	COG2199	diguanylate cyclase activity
IL_RS08620	COG0037	tRNA processing
IL_RS08625	COG0825	malonyl-CoA metabolic process
IL_RS08630	COG0587	DNA-directed DNA polymerase activity
IL_RS08635	COG1252	NADH dehydrogenase
IL_RS08640	COG0339	signal peptide processing
IL_RS08665	COG0328	RNA-DNA hybrid ribonuclease activity
IL_RS08670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IL_RS08675	COG2226	methyltransferase
IL_RS08680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IL_RS08685	COG0741	lytic transglycosylase activity
IL_RS08685	COG1388	LysM domain
IL_RS08695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IL_RS08700	COG3115	cell septum assembly
IL_RS08710	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IL_RS08715	COG1322	Protein conserved in bacteria
IL_RS08725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IL_RS08735	COG1760	l-serine dehydratase
IL_RS08755	COG0023	Translation Initiation Factor
IL_RS08770	COG0745	RESPONSE REGULATOR receiver
IL_RS08775	COG1228	amidohydrolase
IL_RS08780	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IL_RS08800	COG1605	Chorismate mutase
IL_RS08800	COG0287	Prephenate dehydrogenase
IL_RS08805	COG0484	heat shock protein binding
IL_RS08810	COG0335	large ribosomal subunit rRNA binding
IL_RS08815	COG0336	Belongs to the RNA methyltransferase TrmD family
IL_RS08820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IL_RS08825	COG0228	four-way junction DNA binding
IL_RS08830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IL_RS08840	COG4536	flavin adenine dinucleotide binding
IL_RS08850	COG2918	glutathione biosynthetic process
IL_RS08855	COG3437	response regulator, receiver
IL_RS08855	COG2205	protein histidine kinase activity
IL_RS08855	COG3850	Histidine kinase
IL_RS08855	COG4999	Histidine kinase
IL_RS08865	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IL_RS08895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IL_RS08900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IL_RS08905	COG2137	regulation of response to DNA damage stimulus
IL_RS08930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IL_RS08935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IL_RS08940	COG0009	L-threonylcarbamoyladenylate synthase
IL_RS08945	COG0613	PHP domain protein
IL_RS08950	COG0446	pyridine nucleotide-disulphide oxidoreductase
IL_RS08950	COG1902	pentaerythritol trinitrate reductase activity
IL_RS08965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IL_RS08970	COG0512	Glutamine amidotransferase of anthranilate synthase
IL_RS08975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IL_RS08980	COG0134	indole-3-glycerol-phosphate synthase activity
IL_RS08980	COG0135	phosphoribosylanthranilate isomerase activity
IL_RS08990	COG0159	tryptophan synthase activity
IL_RS08995	COG2917	probably involved in intracellular septation
IL_RS09000	COG2350	Protein conserved in bacteria
IL_RS09010	COG3174	membrane
IL_RS09030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IL_RS09035	COG1090	epimerase
IL_RS09040	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IL_RS09045	COG4181	ATPase activity
IL_RS09075	COG0288	reversible hydration of carbon dioxide
IL_RS09080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IL_RS09095	COG0583	DNA-binding transcription factor activity
IL_RS09110	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS09120	COG0427	acetyl-CoA hydrolase
IL_RS09125	COG1794	racemase activity, acting on amino acids and derivatives
IL_RS09150	COG3012	SEC-C Motif Domain Protein
IL_RS09155	COG5001	Diguanylate cyclase
IL_RS09160	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS09180	COG0556	nucleotide-excision repair
IL_RS09185	COG0534	Mate efflux family protein
IL_RS09190	COG0436	Aminotransferase
IL_RS09210	COG0671	phosphoesterase, PA-phosphatase related
IL_RS09215	COG4657	Part of a membrane complex involved in electron transport
IL_RS09220	COG2878	Part of a membrane complex involved in electron transport
IL_RS09225	COG4656	Part of a membrane complex involved in electron transport
IL_RS09230	COG4658	electron transport chain
IL_RS09235	COG4659	FMN binding
IL_RS09240	COG4660	Part of a membrane complex involved in electron transport
IL_RS09245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IL_RS09255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IL_RS09260	COG0450	alkyl hydroperoxide reductase
IL_RS09265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IL_RS09275	COG3385	transposase activity
IL_RS09280	COG2267	carboxylic ester hydrolase activity
IL_RS09340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IL_RS09345	COG0823	Involved in the tonB-independent uptake of proteins
IL_RS09355	COG2186	Transcriptional regulator
IL_RS09360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IL_RS09365	COG2983	Belongs to the UPF0260 family
IL_RS09370	COG2951	lytic endotransglycosylase activity
IL_RS09375	COG3100	YcgL domain-containing protein
IL_RS09380	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IL_RS09385	COG0318	PFAM AMP-dependent synthetase and ligase
IL_RS09405	COG1214	PFAM Peptidase M22, glycoprotease
IL_RS09410	COG1199	ATP-dependent helicase activity
IL_RS09420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IL_RS09425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IL_RS09430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IL_RS09435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IL_RS09435	COG0131	Imidazoleglycerol-phosphate dehydratase
IL_RS09440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IL_RS09445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IL_RS09450	COG0107	imidazoleglycerol-phosphate synthase activity
IL_RS09455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IL_RS09455	COG0140	phosphoribosyl-ATP diphosphatase activity
IL_RS09460	COG0534	Mate efflux family protein
IL_RS09465	COG0596	Alpha beta hydrolase
IL_RS09470	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IL_RS09475	COG0563	adenylate kinase activity
IL_RS09480	COG0326	Molecular chaperone. Has ATPase activity
IL_RS09485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IL_RS09490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IL_RS09495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IL_RS09500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IL_RS09505	COG2204	response regulator
IL_RS09515	COG3220	belongs to the UPF0276 family
IL_RS09530	COG0848	biopolymer transport protein
IL_RS09535	COG0811	peptide transport
IL_RS09555	COG0123	including yeast histone deacetylase and acetoin utilization protein
IL_RS09565	COG1024	Enoyl-CoA hydratase
IL_RS09570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IL_RS09590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IL_RS09600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IL_RS09600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IL_RS09605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IL_RS09610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IL_RS09615	COG0488	(ABC) transporter
IL_RS09620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IL_RS09630	COG0560	Phosphoserine phosphatase
IL_RS09640	COG0084	hydrolase, TatD family'
IL_RS09645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IL_RS09655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IL_RS09660	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IL_RS09665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IL_RS09670	COG0456	acetyltransferase
IL_RS09685	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IL_RS09690	COG0729	surface antigen
IL_RS09730	COG0203	ribosomal protein L17
IL_RS09735	COG0202	RNA polymerase activity
IL_RS09740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IL_RS09745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IL_RS09750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IL_RS09755	COG0201	protein transport
IL_RS09760	COG0200	Binds to the 23S rRNA
IL_RS09765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IL_RS09770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IL_RS09775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IL_RS09780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IL_RS09785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IL_RS09790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IL_RS09795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IL_RS09800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IL_RS09805	COG2111	Na H antiporter
IL_RS09805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IL_RS09810	COG1006	Multisubunit Na H antiporter MnhC subunit
IL_RS09815	COG0651	ATP synthesis coupled electron transport
IL_RS09820	COG1863	multisubunit Na H antiporter MnhE subunit
IL_RS09825	COG2212	antiporter activity
IL_RS09830	COG1320	monovalent cation:proton antiporter activity
IL_RS09840	COG3385	transposase activity
IL_RS09845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IL_RS09850	COG0255	Belongs to the universal ribosomal protein uL29 family
IL_RS09855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IL_RS09860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IL_RS09865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IL_RS09870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IL_RS09875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IL_RS09880	COG0089	rRNA binding
IL_RS09885	COG0088	Forms part of the polypeptide exit tunnel
IL_RS09890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IL_RS09895	COG0051	transcription antitermination factor activity, RNA binding
IL_RS09910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IL_RS09915	COG0735	belongs to the Fur family
IL_RS09935	COG0305	Participates in initiation and elongation during chromosome replication
IL_RS09950	COG1595	DNA-templated transcription, initiation
IL_RS09955	COG0359	binds to the 23S rRNA
IL_RS09960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IL_RS09965	COG2965	DNA replication, synthesis of RNA primer
IL_RS09970	COG0360	Binds together with S18 to 16S ribosomal RNA
IL_RS09980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IL_RS09985	COG0557	exoribonuclease II activity
IL_RS10010	COG0795	lipopolysaccharide-transporting ATPase activity
IL_RS10015	COG0795	lipopolysaccharide-transporting ATPase activity
IL_RS10020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IL_RS10025	COG2927	DNA polymerase III (CHI subunit)
IL_RS10030	COG0525	valine-tRNA ligase activity
IL_RS10035	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IL_RS10050	COG0187	DNA topoisomerase II activity
IL_RS10055	COG3151	Protein conserved in bacteria
IL_RS10060	COG0494	nUDIX hydrolase
IL_RS10065	COG1538	Outer membrane efflux protein
IL_RS10070	COG1560	Kdo2-lipid A biosynthetic process
IL_RS10075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IL_RS10080	COG3025	triphosphatase activity
IL_RS10085	COG0506	proline dehydrogenase activity
IL_RS10085	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IL_RS10085	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IL_RS10095	COG1960	acyl-CoA dehydrogenase activity
IL_RS10105	COG3409	Peptidoglycan-binding domain 1 protein
IL_RS10105	COG3267	Type II secretory pathway component ExeA
IL_RS10110	COG0617	tRNA 3'-terminal CCA addition
IL_RS10115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IL_RS10115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IL_RS10120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IL_RS10125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IL_RS10130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IL_RS10135	COG0154	amidase activity
IL_RS10155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IL_RS10160	COG0762	integral membrane protein
IL_RS10175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IL_RS10180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IL_RS10185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IL_RS10190	COG2885	chlorophyll binding
IL_RS10200	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IL_RS10205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IL_RS10210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IL_RS10215	COG1519	Transferase
IL_RS10225	COG3046	protein related to deoxyribodipyrimidine photolyase
IL_RS10230	COG3040	lipid binding
IL_RS10235	COG0513	Belongs to the DEAD box helicase family
IL_RS10245	COG1012	belongs to the aldehyde dehydrogenase family
IL_RS10250	COG3118	belongs to the thioredoxin family
IL_RS10255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IL_RS10260	COG0733	neurotransmitter:sodium symporter activity
IL_RS10265	COG1444	tRNA N-acetyltransferase activity
IL_RS10270	COG1505	serine-type exopeptidase activity
IL_RS10285	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IL_RS10290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IL_RS10295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IL_RS10295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IL_RS10300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IL_RS10305	COG2205	protein histidine kinase activity
IL_RS10305	COG0784	Response regulator, receiver
IL_RS10315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IL_RS10330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IL_RS10335	COG1785	Belongs to the alkaline phosphatase family
IL_RS10355	COG0668	transmembrane transport
IL_RS10365	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IL_RS10375	COG3156	type II secretion system protein K
IL_RS10380	COG4795	General secretion pathway protein
IL_RS10395	COG2165	general secretion pathway protein
IL_RS10400	COG1459	type II secretion system
IL_RS10405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IL_RS10415	COG3031	protein transport across the cell outer membrane
IL_RS10420	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IL_RS10425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IL_RS10430	COG1160	GTP binding
IL_RS10435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IL_RS10440	COG2976	Protein conserved in bacteria
IL_RS10445	COG0124	histidyl-tRNA synthetase
IL_RS10450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IL_RS10455	COG1426	Protein conserved in bacteria
IL_RS10465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IL_RS10470	COG0105	UTP biosynthetic process
IL_RS10475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IL_RS10480	COG1104	cysteine desulfurase activity
IL_RS10485	COG1959	2 iron, 2 sulfur cluster binding
IL_RS10530	COG3038	cytochrome b561
IL_RS10545	COG1793	dna ligase
IL_RS10555	COG3093	addiction module antidote protein HigA
IL_RS10565	COG1136	(ABC) transporter
IL_RS10575	COG0577	efflux transmembrane transporter activity
IL_RS10585	COG4191	Histidine kinase
IL_RS10665	COG0488	(ABC) transporter
IL_RS10675	COG0778	Nitroreductase
IL_RS10695	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IL_RS10750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IL_RS10750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IL_RS10755	COG0509	glycine decarboxylation via glycine cleavage system
IL_RS10760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IL_RS10765	COG0583	DNA-binding transcription factor activity
IL_RS10770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IL_RS10775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IL_RS10780	COG0006	proline dipeptidase activity
IL_RS10785	COG3079	Belongs to the UPF0149 family
IL_RS10790	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IL_RS10800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IL_RS10805	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IL_RS10810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IL_RS10815	COG0704	Plays a role in the regulation of phosphate uptake
IL_RS10820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IL_RS10825	COG0573	inorganic phosphate transmembrane transporter activity
IL_RS10830	COG0573	inorganic phosphate transmembrane transporter activity
IL_RS10840	COG5002	protein histidine kinase activity
IL_RS10865	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IL_RS10870	COG0848	biopolymer transport protein
IL_RS10875	COG0811	peptide transport
IL_RS10880	COG0811	peptide transport
IL_RS10890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IL_RS10890	COG4191	Histidine kinase
IL_RS10895	COG2974	May be involved in recombination
IL_RS10910	COG0640	Transcriptional regulator
IL_RS10915	COG0798	PFAM Bile acid sodium symporter
IL_RS10920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IL_RS10935	COG0659	secondary active sulfate transmembrane transporter activity
IL_RS10940	COG0589	response to stress
IL_RS10945	COG0513	Belongs to the DEAD box helicase family
IL_RS10955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IL_RS10955	COG0301	tRNA thio-modification
IL_RS10965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IL_RS10970	COG1722	exodeoxyribonuclease VII activity
IL_RS10975	COG0142	geranyltranstransferase activity
IL_RS10980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IL_RS10985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IL_RS10990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IL_RS10995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IL_RS11000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IL_RS11020	COG3022	response to hydroperoxide
IL_RS11025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IL_RS11030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IL_RS11035	COG1862	Preprotein translocase
IL_RS11040	COG3284	Transcriptional regulator
IL_RS11045	COG2860	membrane
IL_RS11050	COG0784	Response regulator, receiver
IL_RS11050	COG2205	protein histidine kinase activity
IL_RS11050	COG2198	Histidine kinase
IL_RS11065	COG2610	gluconate transmembrane transporter activity
IL_RS11075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IL_RS11090	COG0189	ligase activity
IL_RS11095	COG0456	acetyltransferase
IL_RS11100	COG0584	glycerophosphoryl diester phosphodiesterase
IL_RS11105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IL_RS11115	COG0004	ammonium transporteR
IL_RS11120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IL_RS11125	COG0628	permease
IL_RS11145	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS11150	COG0840	transmembrane signaling receptor activity
IL_RS11165	COG0668	transmembrane transport
IL_RS11175	COG4771	TonB-dependent receptor
IL_RS11185	COG3844	kynureninase activity
IL_RS11195	COG1944	ATP diphosphatase activity
IL_RS11235	COG0583	DNA-binding transcription factor activity
IL_RS11245	COG2249	NAD(P)H dehydrogenase (quinone) activity
IL_RS11300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IL_RS11310	COG2815	serine threonine protein kinase
IL_RS11310	COG0515	serine threonine protein kinase
IL_RS11315	COG0343	queuine tRNA-ribosyltransferase activity
IL_RS11320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IL_RS11325	COG0306	phosphate transporter
IL_RS11330	COG1392	Phosphate transport regulator
IL_RS11350	COG0126	phosphoglycerate kinase activity
IL_RS11355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IL_RS11360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IL_RS11365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IL_RS11370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IL_RS11375	COG0189	ligase activity
IL_RS11380	COG1678	Uncharacterized ACR, COG1678
IL_RS11385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IL_RS11400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IL_RS11405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IL_RS11410	COG0564	pseudouridine synthase activity
IL_RS11420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IL_RS11425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IL_RS11435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IL_RS11440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IL_RS11445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IL_RS11450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IL_RS11455	COG2967	ApaG domain
IL_RS11460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IL_RS11465	COG0840	transmembrane signaling receptor activity
IL_RS11470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IL_RS11475	COG0739	heme binding
IL_RS11480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IL_RS11485	COG0006	proline dipeptidase activity
IL_RS11490	COG0316	Belongs to the HesB IscA family
IL_RS11500	COG0038	chloride channel
IL_RS11505	COG1981	membrane
IL_RS11510	COG0540	Belongs to the ATCase OTCase family
IL_RS11515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IL_RS11520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IL_RS11525	COG1643	Atp-dependent helicase
IL_RS11530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IL_RS11535	COG1489	DNA binding
IL_RS11545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IL_RS11555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IL_RS11560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IL_RS11565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IL_RS11570	COG0076	glutamate decarboxylase activity
IL_RS11580	COG0842	Transport permease protein
IL_RS11585	COG1131	(ABC) transporter
IL_RS11590	COG0163	prenyltransferase activity
IL_RS11595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IL_RS11600	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IL_RS11605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IL_RS11610	COG1136	(ABC) transporter
IL_RS11625	COG5001	Diguanylate cyclase
IL_RS11650	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS11680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IL_RS11695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IL_RS11715	COG0459	protein refolding
IL_RS11720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IL_RS11725	COG1324	tolerance protein
IL_RS11730	COG4232	protein-disulfide reductase activity
IL_RS11735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IL_RS11740	COG0511	ligase activity, forming carbon-carbon bonds
IL_RS11745	COG0439	Biotin carboxylase
IL_RS11750	COG2264	protein methyltransferase activity
IL_RS11755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IL_RS11760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IL_RS11775	COG0151	Belongs to the GarS family
IL_RS11780	COG2200	EAL domain
IL_RS11785	COG3085	chromosome segregation
IL_RS11795	COG1914	H( )-stimulated, divalent metal cation uptake system
IL_RS11800	COG0427	acetyl-CoA hydrolase
IL_RS11805	COG0123	including yeast histone deacetylase and acetoin utilization protein
IL_RS11810	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IL_RS11825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IL_RS11830	COG1162	GTPase activity
IL_RS11835	COG0688	phosphatidylethanolamine metabolic process
IL_RS11855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IL_RS11865	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IL_RS11870	COG0545	Peptidyl-prolyl cis-trans isomerase
IL_RS11880	COG2900	Belongs to the SlyX family
IL_RS11885	COG3954	Phosphoribulokinase
IL_RS11890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IL_RS11895	COG1765	OsmC-like protein
IL_RS11905	COG1012	belongs to the aldehyde dehydrogenase family
IL_RS11915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IL_RS11935	COG5001	Diguanylate cyclase
IL_RS11945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IL_RS11970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IL_RS11980	COG1741	Belongs to the pirin family
IL_RS11985	COG1742	UPF0060 membrane protein
IL_RS12000	COG1025	Belongs to the peptidase M16 family
IL_RS12010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IL_RS12025	COG1671	Belongs to the UPF0178 family
IL_RS12030	COG0450	alkyl hydroperoxide reductase
IL_RS12040	COG3300	MHYT domain
IL_RS12040	COG5001	Diguanylate cyclase
IL_RS12050	COG3577	Aspartyl protease
IL_RS12055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IL_RS12065	COG1253	flavin adenine dinucleotide binding
IL_RS12075	COG1054	Belongs to the UPF0176 family
IL_RS12080	COG0783	Belongs to the Dps family
IL_RS12100	COG3201	nicotinamide mononucleotide transporter
IL_RS12110	COG1629	transport
IL_RS12110	COG4774	siderophore transport
IL_RS12120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IL_RS12135	COG0513	Belongs to the DEAD box helicase family
IL_RS12140	COG0248	Ppx GppA phosphatase
IL_RS12150	COG5001	Diguanylate cyclase
IL_RS12150	COG4251	negative regulation of phosphorylation
IL_RS12150	COG3706	GGDEF domain
IL_RS12150	COG2203	Gaf domain
IL_RS12160	COG0805	protein transport
IL_RS12165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IL_RS12170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IL_RS12185	COG2226	methyltransferase
IL_RS12190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IL_RS12195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IL_RS12200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IL_RS12205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IL_RS12205	COG3153	acetyltransferase
IL_RS12220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IL_RS12225	COG1758	RNA polymerase activity
IL_RS12230	COG0194	GDP metabolic process
IL_RS12235	COG2807	transmembrane transport
IL_RS12240	COG1309	transcriptional regulator
IL_RS12260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IL_RS12275	COG1959	2 iron, 2 sulfur cluster binding
IL_RS12300	COG0471	metal ion transport
IL_RS12305	COG2824	Alkylphosphonate utilization operon protein PhnA
IL_RS12335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IL_RS12340	COG0842	Transport permease protein
IL_RS12340	COG1129	ABC transporter
IL_RS12345	COG0842	Transport permease protein
IL_RS12375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IL_RS12405	COG1279	arginine transmembrane transporter activity
IL_RS12420	COG1561	YicC-like family, N-terminal region
IL_RS12425	COG0596	Alpha beta hydrolase
IL_RS12430	COG1595	DNA-templated transcription, initiation
IL_RS12435	COG2840	Smr protein MutS2
IL_RS12440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IL_RS12450	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS12465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IL_RS12475	COG2267	carboxylic ester hydrolase activity
IL_RS12480	COG2205	protein histidine kinase activity
IL_RS12485	COG0745	RESPONSE REGULATOR receiver
IL_RS12495	COG3852	Histidine kinase
IL_RS12500	COG0174	glutamine synthetase
IL_RS12505	COG1217	gtp-binding protein TYPA
IL_RS12510	COG1272	protein, Hemolysin III
IL_RS12525	COG1285	pathogenesis
IL_RS12550	COG1295	ribonuclease BN
IL_RS12555	COG1490	D-aminoacyl-tRNA deacylase activity
IL_RS12560	COG0456	acetyltransferase
IL_RS12565	COG2986	histidine ammonia-lyase
IL_RS12570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IL_RS12580	COG1228	amidohydrolase
IL_RS12590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IL_RS12600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IL_RS12605	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IL_RS12615	COG0018	arginyl-trna synthetase
IL_RS12620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IL_RS12625	COG0254	rRNA binding
IL_RS12630	COG0281	malic enzyme
IL_RS12635	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS12640	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IL_RS12645	COG0527	aspartate kinase activity
IL_RS12645	COG0460	homoserine dehydrogenase
IL_RS12650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IL_RS12670	COG4796	Type ii and iii secretion system protein
IL_RS12675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IL_RS12680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IL_RS12690	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IL_RS12695	COG2153	protein acetylation
IL_RS12700	COG0742	ribosomal rna small subunit methyltransferase
IL_RS12705	COG0678	peroxiredoxin activity
IL_RS12710	COG2081	HI0933 family
IL_RS12730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IL_RS12755	COG4206	TonB-dependent receptor
IL_RS12760	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
IL_RS12765	COG4771	TonB-dependent receptor
IL_RS12770	COG0583	DNA-binding transcription factor activity
IL_RS12775	COG0702	epimerase
IL_RS12780	COG1278	Cold shock
IL_RS12810	COG1573	uracil-dna glycosylase
IL_RS12840	COG0490	domain, Protein
IL_RS12840	COG0471	metal ion transport
IL_RS12860	COG2226	methyltransferase
IL_RS12865	COG3591	Belongs to the peptidase S1B family
IL_RS12865	COG4990	cell redox homeostasis
IL_RS12890	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IL_RS12910	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IL_RS12915	COG3549	Plasmid maintenance system killer
IL_RS12920	COG3093	addiction module antidote protein HigA
IL_RS12940	COG2161	toxin-antitoxin pair type II binding
IL_RS12965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IL_RS12970	COG1074	ATP-dependent DNA helicase activity
IL_RS12975	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IL_RS12990	COG3706	GGDEF domain
IL_RS13010	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IL_RS13020	COG1132	(ABC) transporter
IL_RS13040	COG4251	negative regulation of phosphorylation
IL_RS13040	COG5001	Diguanylate cyclase
IL_RS13040	COG3706	GGDEF domain
IL_RS13040	COG2203	Gaf domain
IL_RS13060	COG2962	Rard protein
IL_RS13065	COG1764	response to oxidative stress
IL_RS13075	COG1011	Hydrolase
IL_RS13090	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IL_RS13095	COG0019	diaminopimelate decarboxylase activity
IL_RS13100	COG0181	hydroxymethylbilane synthase activity
IL_RS13125	COG3038	cytochrome b561
IL_RS13130	COG3547	Transposase (IS116 IS110 IS902 family)
IL_RS13160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IL_RS13165	COG0587	DNA-directed DNA polymerase activity
IL_RS13180	COG0204	Acyl-transferase
IL_RS13185	COG0668	transmembrane transport
IL_RS13190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IL_RS13195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IL_RS13200	COG0348	domain, Protein
IL_RS13215	COG0450	alkyl hydroperoxide reductase
IL_RS13220	COG0583	DNA-binding transcription factor activity
IL_RS13225	COG0069	glutamate synthase activity
IL_RS13230	COG2133	pyrroloquinoline quinone binding
IL_RS13235	COG4772	TonB-dependent receptor
IL_RS13250	COG3852	Histidine kinase
IL_RS13290	COG0701	Predicted permease
IL_RS13300	COG1349	DNA-binding transcription factor activity
IL_RS13375	COG3290	protein histidine kinase activity
IL_RS13420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IL_RS13425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IL_RS13430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IL_RS13435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IL_RS13440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IL_RS13445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IL_RS13450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IL_RS13455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IL_RS13465	COG0356	it plays a direct role in the translocation of protons across the membrane
IL_RS13475	COG1475	DNA binding
IL_RS13480	COG1192	Involved in chromosome partitioning
IL_RS13485	COG0357	Ribosomal RNA small subunit methyltransferase G
IL_RS13490	COG0445	tRNA wobble uridine modification
IL_RS13495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IL_RS13510	COG2827	Endonuclease containing a URI domain
IL_RS13515	COG1289	transmembrane transporter activity
IL_RS13520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IL_RS13525	COG0706	membrane insertase activity
IL_RS13530	COG0594	ribonuclease P activity
IL_RS13535	COG0230	Belongs to the bacterial ribosomal protein bL34 family