locus-tag	class	description
EKN56_RS00010	COG0592	DNA-directed DNA polymerase activity
EKN56_RS00050	COG3677	Transposase
EKN56_RS00060	COG2885	chlorophyll binding
EKN56_RS00060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EKN56_RS00085	COG4932	domain protein
EKN56_RS00085	COG3266	domain, Protein
EKN56_RS00085	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EKN56_RS00145	COG0477	Major facilitator Superfamily
EKN56_RS00150	COG0443	Heat shock 70 kDa protein
EKN56_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
EKN56_RS00160	COG0473	3-isopropylmalate dehydrogenase activity
EKN56_RS00165	COG2214	Heat shock protein DnaJ domain protein
EKN56_RS00175	COG0477	Major facilitator Superfamily
EKN56_RS00185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EKN56_RS00195	COG2186	Transcriptional regulator
EKN56_RS00200	COG3734	2-keto-3-deoxy-galactonokinase
EKN56_RS00205	COG0800	Aldolase
EKN56_RS00210	COG4948	Mandelate Racemase Muconate Lactonizing
EKN56_RS00215	COG2271	Major facilitator Superfamily
EKN56_RS00220	COG0823	Involved in the tonB-independent uptake of proteins
EKN56_RS00225	COG1652	LysM domain
EKN56_RS00245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKN56_RS00275	COG5645	(Lipo)protein
EKN56_RS00280	COG0071	Belongs to the small heat shock protein (HSP20) family
EKN56_RS00285	COG0071	Belongs to the small heat shock protein (HSP20) family
EKN56_RS00290	COG3977	Valine--pyruvate aminotransferase
EKN56_RS00310	COG2885	chlorophyll binding
EKN56_RS00325	COG2818	Glycosylase
EKN56_RS00335	COG0751	glycine-tRNA ligase activity
EKN56_RS00340	COG0471	metal ion transport
EKN56_RS00350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EKN56_RS00350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EKN56_RS00355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EKN56_RS00365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EKN56_RS00400	COG1011	Hydrolase
EKN56_RS00405	COG1295	ribonuclease BN
EKN56_RS00415	COG0456	acetyltransferase
EKN56_RS00420	COG2982	Protein involved in outer membrane biogenesis
EKN56_RS00425	COG2233	PERMEase
EKN56_RS00430	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
EKN56_RS00435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EKN56_RS00440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKN56_RS00445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EKN56_RS00455	COG0194	GDP metabolic process
EKN56_RS00465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EKN56_RS00475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKN56_RS00480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EKN56_RS00485	COG2271	Major facilitator Superfamily
EKN56_RS00490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKN56_RS00500	COG1609	Transcriptional regulator
EKN56_RS00505	COG3706	GGDEF domain
EKN56_RS00515	COG2823	Periplasmic or secreted lipoprotein
EKN56_RS00520	COG5487	UPF0391 membrane protein
EKN56_RS00530	COG0477	Major facilitator Superfamily
EKN56_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS00550	COG1063	alcohol dehydrogenase
EKN56_RS00580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EKN56_RS00585	COG3069	C4-dicarboxylate transmembrane transporter activity
EKN56_RS00595	COG1561	YicC-like family, N-terminal region
EKN56_RS00610	COG1494	fructose-1,6-bisphosphatase
EKN56_RS00620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EKN56_RS00625	COG3074	FtsZ-dependent cytokinesis
EKN56_RS00630	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EKN56_RS00640	COG1575	Belongs to the MenA family. Type 1 subfamily
EKN56_RS00645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EKN56_RS00650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EKN56_RS00655	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EKN56_RS00660	COG1609	Transcriptional regulator
EKN56_RS00665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EKN56_RS00670	COG0254	rRNA binding
EKN56_RS00675	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EKN56_RS00685	COG0626	cystathionine gamma-synthase activity
EKN56_RS00690	COG0527	aspartate kinase activity
EKN56_RS00690	COG0460	homoserine dehydrogenase
EKN56_RS00710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EKN56_RS00715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKN56_RS00730	COG0137	argininosuccinate synthase activity
EKN56_RS00735	COG0165	Argininosuccinate lyase
EKN56_RS00750	COG3210	domain, Protein
EKN56_RS00750	COG3210	domain, Protein
EKN56_RS00755	COG2831	hemolysin activation secretion protein
EKN56_RS00760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKN56_RS00765	COG0678	peroxiredoxin activity
EKN56_RS00765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EKN56_RS00785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EKN56_RS00795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EKN56_RS00830	COG0583	DNA-binding transcription factor activity
EKN56_RS00835	COG3085	chromosome segregation
EKN56_RS00840	COG0606	chelatase, subunit chli
EKN56_RS00855	COG3978	acetolactate synthase activity
EKN56_RS00865	COG0129	dihydroxy-acid dehydratase activity
EKN56_RS00870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EKN56_RS00890	COG3152	Membrane
EKN56_RS00900	COG0248	Ppx GppA phosphatase
EKN56_RS00910	COG3118	belongs to the thioredoxin family
EKN56_RS00915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EKN56_RS00920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EKN56_RS00930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EKN56_RS00935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EKN56_RS00940	COG1088	dTDP-glucose 4,6-dehydratase activity
EKN56_RS00945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EKN56_RS00950	COG0456	acetyltransferase
EKN56_RS00955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EKN56_RS00960	COG2244	polysaccharide biosynthetic process
EKN56_RS00975	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EKN56_RS01010	COG3071	HemY protein
EKN56_RS01015	COG2959	enzyme of heme biosynthesis
EKN56_RS01020	COG1587	Uroporphyrinogen-III synthase
EKN56_RS01025	COG0181	hydroxymethylbilane synthase activity
EKN56_RS01045	COG0019	diaminopimelate decarboxylase activity
EKN56_RS01065	COG1011	Hydrolase
EKN56_RS01070	COG0210	DNA helicase
EKN56_RS01080	COG3180	Ammonia monooxygenase
EKN56_RS01090	COG0514	ATP-dependent DNA helicase (RecQ)
EKN56_RS01110	COG2610	gluconate transmembrane transporter activity
EKN56_RS01115	COG3265	gluconokinase activity
EKN56_RS01120	COG1609	Transcriptional regulator
EKN56_RS01125	COG0129	dihydroxy-acid dehydratase activity
EKN56_RS01135	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EKN56_RS01140	COG0697	spore germination
EKN56_RS01145	COG0583	DNA-binding transcription factor activity
EKN56_RS01160	COG1739	Uncharacterized protein family UPF0029
EKN56_RS01170	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EKN56_RS01225	COG3162	membrane
EKN56_RS01230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EKN56_RS01235	COG1301	dicarboxylic acid transport
EKN56_RS01245	COG0534	Mate efflux family protein
EKN56_RS01250	COG3447	MASE1 domain protein
EKN56_RS01250	COG5002	protein histidine kinase activity
EKN56_RS01250	COG5001	Diguanylate cyclase
EKN56_RS01265	COG2249	NAD(P)H dehydrogenase (quinone) activity
EKN56_RS01285	COG1234	tRNA 3'-trailer cleavage
EKN56_RS01300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKN56_RS01315	COG1122	ATPase activity
EKN56_RS01320	COG1122	ATPase activity
EKN56_RS01360	COG1596	polysaccharide export
EKN56_RS01375	COG4232	protein-disulfide reductase activity
EKN56_RS01385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EKN56_RS01390	COG1027	Aspartate ammonia-lyase
EKN56_RS01400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EKN56_RS01415	COG1509	lysine 2,3-aminomutase activity
EKN56_RS01420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EKN56_RS01445	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EKN56_RS01450	COG2814	Major facilitator Superfamily
EKN56_RS01455	COG3246	L-lysine catabolic process to acetate
EKN56_RS01460	COG0183	Belongs to the thiolase family
EKN56_RS01465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EKN56_RS01470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EKN56_RS01480	COG1129	ABC transporter
EKN56_RS01485	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKN56_RS01495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKN56_RS01500	COG1609	Transcriptional regulator
EKN56_RS01505	COG2860	membrane
EKN56_RS01510	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EKN56_RS01515	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EKN56_RS01520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EKN56_RS01525	COG1053	succinate dehydrogenase
EKN56_RS01530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EKN56_RS01535	COG3264	Mechanosensitive ion channel
EKN56_RS01535	COG1511	domain protein
EKN56_RS01600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EKN56_RS01605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EKN56_RS01605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EKN56_RS01610	COG0802	atpase or kinase
EKN56_RS01615	COG0860	N-Acetylmuramoyl-L-alanine amidase
EKN56_RS01620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EKN56_RS01635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EKN56_RS01640	COG0330	HflC and HflK could
EKN56_RS01645	COG0330	HflC and HflK could
EKN56_RS01650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EKN56_RS01650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EKN56_RS01650	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EKN56_RS01655	COG1105	Belongs to the carbohydrate kinase PfkB family
EKN56_RS01665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EKN56_RS01670	COG1959	2 iron, 2 sulfur cluster binding
EKN56_RS01675	COG0557	exoribonuclease II activity
EKN56_RS01680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKN56_RS01685	COG0625	glutathione transferase activity
EKN56_RS01705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EKN56_RS01730	COG0251	oxidation-reduction process
EKN56_RS01745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EKN56_RS01750	COG0359	binds to the 23S rRNA
EKN56_RS01760	COG3061	Opacity-associated protein A
EKN56_RS01765	COG2814	Major facilitator Superfamily
EKN56_RS01770	COG0545	Peptidyl-prolyl cis-trans isomerase
EKN56_RS01775	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EKN56_RS01780	COG1218	3'(2'),5'-bisphosphate nucleotidase
EKN56_RS01790	COG1253	flavin adenine dinucleotide binding
EKN56_RS01800	COG0729	surface antigen
EKN56_RS01805	COG2911	Protein conserved in bacteria
EKN56_RS01810	COG2105	PFAM AIG2 family protein
EKN56_RS01825	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EKN56_RS01830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EKN56_RS01835	COG1438	arginine binding
EKN56_RS01840	COG0039	L-malate dehydrogenase activity
EKN56_RS01845	COG3423	Transcriptional regulator
EKN56_RS01860	COG0142	geranyltranstransferase activity
EKN56_RS01865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EKN56_RS01875	COG0697	spore germination
EKN56_RS01880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EKN56_RS01890	COG2027	D-alanyl-D-alanine carboxypeptidase
EKN56_RS01900	COG1534	Rna-binding protein
EKN56_RS01905	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EKN56_RS01910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EKN56_RS01920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EKN56_RS01925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EKN56_RS01940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EKN56_RS01950	COG0582	viral genome integration into host DNA
EKN56_RS01995	COG3501	Rhs element vgr protein
EKN56_RS02015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKN56_RS02035	COG3596	GTP binding
EKN56_RS02055	COG3468	outer membrane autotransporter barrel domain protein
EKN56_RS02090	COG0523	cobalamin synthesis protein
EKN56_RS02095	COG2879	small protein
EKN56_RS02100	COG1966	Carbon starvation protein
EKN56_RS02115	COG0195	Participates in both transcription termination and antitermination
EKN56_RS02120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EKN56_RS02130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EKN56_RS02140	COG0714	Associated with various cellular activities
EKN56_RS02170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EKN56_RS02175	COG1185	polyribonucleotide nucleotidyltransferase activity
EKN56_RS02190	COG0513	Belongs to the DEAD box helicase family
EKN56_RS02200	COG2391	methyltransferase activity
EKN56_RS02205	COG0425	Belongs to the sulfur carrier protein TusA family
EKN56_RS02210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EKN56_RS02215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKN56_RS02220	COG2814	Major facilitator Superfamily
EKN56_RS02225	COG0109	protoheme IX farnesyltransferase activity
EKN56_RS02230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EKN56_RS02235	COG1845	cytochrome c oxidase, subunit III
EKN56_RS02240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EKN56_RS02245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EKN56_RS02250	COG1988	membrane-bound metal-dependent
EKN56_RS02260	COG0702	epimerase
EKN56_RS02265	COG0826	peptidase U32
EKN56_RS02270	COG0826	peptidase U32
EKN56_RS02275	COG3154	lipid carrier protein
EKN56_RS02280	COG3153	acetyltransferase
EKN56_RS02300	COG0602	queuosine metabolic process
EKN56_RS02325	COG1312	Catalyzes the dehydration of D-mannonate
EKN56_RS02330	COG2186	Transcriptional regulator
EKN56_RS02340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EKN56_RS02350	COG0246	Mannitol dehydrogenase
EKN56_RS02355	COG1904	glucuronate isomerase
EKN56_RS02360	COG0348	domain, Protein
EKN56_RS02365	COG2239	Acts as a magnesium transporter
EKN56_RS02380	COG3037	sugar-specific permease SgaT UlaA
EKN56_RS02420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EKN56_RS02430	COG0671	phosphoesterase, PA-phosphatase related
EKN56_RS02445	COG4807	Protein conserved in bacteria
EKN56_RS02450	COG0583	DNA-binding transcription factor activity
EKN56_RS02485	COG1609	Transcriptional regulator
EKN56_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS02500	COG4772	TonB-dependent receptor
EKN56_RS02525	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EKN56_RS02530	COG0739	heme binding
EKN56_RS02535	COG0477	Major facilitator Superfamily
EKN56_RS02540	COG4953	penicillin-binding protein 1C
EKN56_RS02545	COG2373	Large extracellular alpha-helical protein
EKN56_RS02565	COG0583	DNA-binding transcription factor activity
EKN56_RS02575	COG1335	isochorismatase
EKN56_RS02595	COG1342	Belongs to the UPF0251 family
EKN56_RS02635	COG3609	addiction module antidote protein, CC2985 family
EKN56_RS02660	COG1072	(Pantothenic acid kinase))
EKN56_RS02665	COG0741	lytic transglycosylase activity
EKN56_RS02675	COG1194	a g-specific adenine glycosylase
EKN56_RS02685	COG3171	Protein conserved in bacteria
EKN56_RS02695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EKN56_RS02700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EKN56_RS02710	COG1872	DUF167
EKN56_RS02715	COG0762	integral membrane protein
EKN56_RS02720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EKN56_RS02725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EKN56_RS02740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EKN56_RS02745	COG1678	Uncharacterized ACR, COG1678
EKN56_RS02750	COG0189	ligase activity
EKN56_RS02755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EKN56_RS02760	COG3091	SprT-like family
EKN56_RS02770	COG1166	arginine decarboxylase activity
EKN56_RS02775	COG2095	MarC family integral membrane protein
EKN56_RS02780	COG0010	Belongs to the arginase family
EKN56_RS02785	COG0431	NADPH-dependent FMN reductase
EKN56_RS02790	COG0501	Belongs to the peptidase M48B family
EKN56_RS02795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EKN56_RS02800	COG0126	phosphoglycerate kinase activity
EKN56_RS02810	COG1279	arginine transmembrane transporter activity
EKN56_RS02815	COG2968	Membrane
EKN56_RS02820	COG0583	DNA-binding transcription factor activity
EKN56_RS02825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EKN56_RS02830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKN56_RS02835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EKN56_RS02845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EKN56_RS02850	COG3079	Belongs to the UPF0149 family
EKN56_RS02860	COG0006	proline dipeptidase activity
EKN56_RS02865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKN56_RS02870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKN56_RS02885	COG0509	glycine decarboxylation via glycine cleavage system
EKN56_RS02890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EKN56_RS02890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EKN56_RS02900	COG1115	amino acid carrier protein
EKN56_RS02910	COG1272	protein, Hemolysin III
EKN56_RS02920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EKN56_RS02930	COG0745	RESPONSE REGULATOR receiver
EKN56_RS02935	COG2205	protein histidine kinase activity
EKN56_RS02945	COG2831	hemolysin activation secretion protein
EKN56_RS03060	COG4383	Mu-like prophage protein gp29
EKN56_RS03100	COG3023	N-Acetylmuramoyl-L-alanine amidase
EKN56_RS03160	COG2842	Transposition protein
EKN56_RS03170	COG3423	Transcriptional regulator
EKN56_RS03180	COG3210	domain, Protein
EKN56_RS03240	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EKN56_RS03260	COG4974	Belongs to the 'phage' integrase family
EKN56_RS03265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EKN56_RS03270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EKN56_RS03275	COG2885	chlorophyll binding
EKN56_RS03280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EKN56_RS03285	COG1960	acyl-CoA dehydrogenase activity
EKN56_RS03305	COG3971	2-oxopent-4-enoate hydratase activity
EKN56_RS03320	COG3384	dioxygenase
EKN56_RS03325	COG1012	belongs to the aldehyde dehydrogenase family
EKN56_RS03335	COG0179	Fumarylacetoacetate (FAA) hydrolase
EKN56_RS03340	COG1846	Transcriptional regulator
EKN56_RS03355	COG1368	sulfuric ester hydrolase activity
EKN56_RS03365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EKN56_RS03385	COG2116	formate transmembrane transporter activity
EKN56_RS03395	COG0583	DNA-binding transcription factor activity
EKN56_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS03410	COG4670	ketone body catabolic process
EKN56_RS03415	COG2610	gluconate transmembrane transporter activity
EKN56_RS03420	COG2226	methyltransferase
EKN56_RS03430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKN56_RS03445	COG1285	pathogenesis
EKN56_RS03480	COG3069	C4-dicarboxylate transmembrane transporter activity
EKN56_RS03490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EKN56_RS03505	COG4771	TonB-dependent receptor
EKN56_RS03510	COG4558	Periplasmic binding protein
EKN56_RS03520	COG3721	Heme iron utilization protein
EKN56_RS03530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKN56_RS03540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EKN56_RS03540	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EKN56_RS03545	COG3122	Protein conserved in bacteria
EKN56_RS03565	COG0583	DNA-binding transcription factor activity
EKN56_RS03570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EKN56_RS03580	COG0549	Belongs to the carbamate kinase family
EKN56_RS03585	COG1304	FMN binding
EKN56_RS03590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EKN56_RS03600	COG1335	isochorismatase
EKN56_RS03615	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS03620	COG2864	formate dehydrogenase
EKN56_RS03645	COG1904	glucuronate isomerase
EKN56_RS03650	COG0246	Mannitol dehydrogenase
EKN56_RS03655	COG2721	sulfolactate sulfo-lyase activity
EKN56_RS03670	COG1760	l-serine dehydratase
EKN56_RS03675	COG0814	amino acid
EKN56_RS03680	COG0861	Integral membrane protein TerC family
EKN56_RS03695	COG1250	3-hydroxyacyl-CoA dehydrogenase
EKN56_RS03740	COG3639	organic phosphonate transmembrane transporter activity
EKN56_RS03745	COG3639	organic phosphonate transmembrane transporter activity
EKN56_RS03750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EKN56_RS03780	COG1609	Transcriptional regulator
EKN56_RS03785	COG0204	Acyl-transferase
EKN56_RS03785	COG0318	PFAM AMP-dependent synthetase and ligase
EKN56_RS03790	COG0477	Major facilitator Superfamily
EKN56_RS03795	COG3121	Chaperone
EKN56_RS03805	COG3188	usher protein
EKN56_RS03825	COG1051	belongs to the nudix hydrolase family
EKN56_RS03830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EKN56_RS03835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EKN56_RS03860	COG1902	pentaerythritol trinitrate reductase activity
EKN56_RS03865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EKN56_RS03875	COG1074	ATP-dependent DNA helicase activity
EKN56_RS03880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKN56_RS03885	COG4607	ABC-type enterochelin transport system periplasmic component
EKN56_RS03890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EKN56_RS03890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EKN56_RS03895	COG0860	N-Acetylmuramoyl-L-alanine amidase
EKN56_RS03920	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EKN56_RS03925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EKN56_RS03935	COG2166	iron-sulfur cluster assembly
EKN56_RS03940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EKN56_RS03950	COG0583	DNA-binding transcription factor activity
EKN56_RS03955	COG2363	Small membrane protein
EKN56_RS03970	COG1611	Belongs to the LOG family
EKN56_RS03975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EKN56_RS03975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EKN56_RS03985	COG3098	single-species biofilm formation
EKN56_RS03995	COG0716	FMN binding
EKN56_RS04020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EKN56_RS04035	COG0540	Belongs to the ATCase OTCase family
EKN56_RS04040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EKN56_RS04055	COG0528	UMP kinase activity
EKN56_RS04070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EKN56_RS04075	COG0575	Belongs to the CDS family
EKN56_RS04080	COG0750	zinc metalloprotease
EKN56_RS04085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKN56_RS04090	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EKN56_RS04095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EKN56_RS04100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EKN56_RS04110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EKN56_RS04115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EKN56_RS04120	COG0587	DNA-directed DNA polymerase activity
EKN56_RS04130	COG2226	methyltransferase
EKN56_RS04135	COG1556	Lactate utilization protein
EKN56_RS04140	COG1139	Iron-sulfur cluster binding protein
EKN56_RS04145	COG0247	lactate metabolic process
EKN56_RS04150	COG1620	l-lactate permease
EKN56_RS04155	COG0346	lactoylglutathione lyase activity
EKN56_RS04160	COG0037	tRNA processing
EKN56_RS04170	COG4568	rho-dependent transcription termination
EKN56_RS04180	COG4681	YaeQ
EKN56_RS04190	COG0442	prolyl-tRNA aminoacylation
EKN56_RS04195	COG1720	tRNA m6t6A37 methyltransferase activity
EKN56_RS04205	COG1464	Belongs to the NlpA lipoprotein family
EKN56_RS04215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EKN56_RS04220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EKN56_RS04250	COG3021	interspecies interaction between organisms
EKN56_RS04255	COG0741	lytic transglycosylase activity
EKN56_RS04255	COG1388	LysM domain
EKN56_RS04260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EKN56_RS04265	COG2226	methyltransferase
EKN56_RS04275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EKN56_RS04290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EKN56_RS04295	COG0121	glutamine amidotransferase
EKN56_RS04300	COG3034	peptidoglycan biosynthetic process
EKN56_RS04305	COG3034	peptidoglycan biosynthetic process
EKN56_RS04310	COG1477	protein flavinylation
EKN56_RS04320	COG2195	Cleaves the N-terminal amino acid of tripeptides
EKN56_RS04325	COG0386	Belongs to the glutathione peroxidase family
EKN56_RS04330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EKN56_RS04335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EKN56_RS04370	COG1073	alpha beta
EKN56_RS04395	COG1280	lysine exporter protein (LysE YggA)
EKN56_RS04405	COG1742	UPF0060 membrane protein
EKN56_RS04410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EKN56_RS04420	COG1114	Component of the transport system for branched-chain amino acids
EKN56_RS04430	COG0450	alkyl hydroperoxide reductase
EKN56_RS04435	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EKN56_RS04440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EKN56_RS04445	COG0343	queuine tRNA-ribosyltransferase activity
EKN56_RS04450	COG1862	Preprotein translocase
EKN56_RS04460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EKN56_RS04480	COG0697	spore germination
EKN56_RS04485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EKN56_RS04490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EKN56_RS04490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EKN56_RS04495	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EKN56_RS04505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EKN56_RS04510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EKN56_RS04515	COG0142	geranyltranstransferase activity
EKN56_RS04520	COG1722	exodeoxyribonuclease VII activity
EKN56_RS04530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKN56_RS04530	COG0301	tRNA thio-modification
EKN56_RS04535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EKN56_RS04545	COG1666	GTP binding
EKN56_RS04560	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKN56_RS04565	COG1129	ABC transporter
EKN56_RS04580	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKN56_RS04585	COG1129	ABC transporter
EKN56_RS04590	COG1879	ABC-type sugar transport system periplasmic component
EKN56_RS04600	COG2160	L-arabinose isomerase activity
EKN56_RS04605	COG0235	Class ii aldolase
EKN56_RS04715	COG4373	Mu-like prophage FluMu protein gp28
EKN56_RS04835	COG0788	formyltetrahydrofolate deformylase activity
EKN56_RS04850	COG0708	Exodeoxyribonuclease III
EKN56_RS04855	COG0494	nUDIX hydrolase
EKN56_RS04860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EKN56_RS04865	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EKN56_RS04875	COG0778	Nitroreductase
EKN56_RS04880	COG0616	signal peptide processing
EKN56_RS04885	COG0252	asparaginase activity
EKN56_RS04890	COG1335	isochorismatase
EKN56_RS04900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EKN56_RS04910	COG3713	MltA-interacting MipA family protein
EKN56_RS04915	COG3009	Protein conserved in bacteria
EKN56_RS04920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EKN56_RS04920	COG3008	intermembrane lipid transfer
EKN56_RS04925	COG2995	paraquat-inducible protein a
EKN56_RS04930	COG0488	(ABC) transporter
EKN56_RS04935	COG0116	Belongs to the methyltransferase superfamily
EKN56_RS04935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EKN56_RS04940	COG0633	Ferredoxin
EKN56_RS04940	COG3217	Mosc domain protein beta barrel domain protein
EKN56_RS04955	COG0308	aminopeptidase N
EKN56_RS04960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EKN56_RS04965	COG0017	Asparaginyl-tRNA synthetase
EKN56_RS04975	COG1448	Aminotransferase
EKN56_RS04980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EKN56_RS04985	COG3108	Peptidase M15
EKN56_RS04990	COG2989	Protein conserved in bacteria
EKN56_RS04995	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EKN56_RS05005	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EKN56_RS05010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKN56_RS05015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EKN56_RS05025	COG2835	tetraacyldisaccharide 4'-kinase activity
EKN56_RS05030	COG1663	tetraacyldisaccharide 4'-kinase activity
EKN56_RS05040	COG2333	competence protein COMEC
EKN56_RS05040	COG0658	competence protein
EKN56_RS05050	COG0539	negative regulation of cytoplasmic translation
EKN56_RS05060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EKN56_RS05065	COG1794	racemase activity, acting on amino acids and derivatives
EKN56_RS05070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EKN56_RS05075	COG0252	asparaginase activity
EKN56_RS05080	COG1944	ATP diphosphatase activity
EKN56_RS05085	COG2116	formate transmembrane transporter activity
EKN56_RS05090	COG1882	Formate acetyltransferase
EKN56_RS05095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EKN56_RS05100	COG2814	Major facilitator Superfamily
EKN56_RS05105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKN56_RS05105	COG2221	Nitrite and sulphite reductase 4Fe-4S
EKN56_RS05115	COG3302	dmso reductase anchor subunit
EKN56_RS05135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EKN56_RS05145	COG3107	peptidoglycan biosynthetic process
EKN56_RS05145	COG1674	ftsk spoiiie
EKN56_RS05150	COG1522	sequence-specific DNA binding
EKN56_RS05155	COG0492	ferredoxin-NADP+ reductase activity
EKN56_RS05160	COG4988	ABC transporter
EKN56_RS05165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EKN56_RS05170	COG3698	Phosphodiester glycosidase
EKN56_RS05180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EKN56_RS05185	COG0542	response to heat
EKN56_RS05190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EKN56_RS05195	COG3593	DNA synthesis involved in DNA repair
EKN56_RS05200	COG2431	L-lysine efflux transmembrane transporter activity
EKN56_RS05205	COG1151	hydroxylamine reductase activity
EKN56_RS05210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EKN56_RS05215	COG0702	epimerase
EKN56_RS05220	COG3023	N-Acetylmuramoyl-L-alanine amidase
EKN56_RS05235	COG2255	four-way junction helicase activity
EKN56_RS05265	COG1979	alcohol dehydrogenase
EKN56_RS05285	COG5001	Diguanylate cyclase
EKN56_RS05285	COG3706	GGDEF domain
EKN56_RS05285	COG2203	Gaf domain
EKN56_RS05285	COG4251	negative regulation of phosphorylation
EKN56_RS05300	COG3539	Fimbrial protein
EKN56_RS05310	COG3121	Chaperone
EKN56_RS05315	COG3539	Fimbrial protein
EKN56_RS05335	COG2926	Belongs to the UPF0265 family
EKN56_RS05345	COG1253	flavin adenine dinucleotide binding
EKN56_RS05350	COG2982	Protein involved in outer membrane biogenesis
EKN56_RS05360	COG0489	protein tyrosine kinase activity
EKN56_RS05370	COG4771	TonB-dependent receptor
EKN56_RS05375	COG4771	TonB-dependent receptor
EKN56_RS05385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKN56_RS05405	COG0833	amino acid
EKN56_RS05410	COG0583	DNA-binding transcription factor activity
EKN56_RS05415	COG2855	membrane
EKN56_RS05420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EKN56_RS05425	COG1105	Belongs to the carbohydrate kinase PfkB family
EKN56_RS05440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EKN56_RS05450	COG0523	cobalamin synthesis protein
EKN56_RS05455	COG0671	phosphoesterase, PA-phosphatase related
EKN56_RS05460	COG0791	NLP P60 protein
EKN56_RS05465	COG4166	transmembrane transport
EKN56_RS05470	COG4174	ABC transporter (Permease)
EKN56_RS05475	COG4239	(ABC) transporter, permease
EKN56_RS05480	COG4172	Belongs to the ABC transporter superfamily
EKN56_RS05490	COG2814	Major facilitator Superfamily
EKN56_RS05495	COG1187	pseudouridine synthase activity
EKN56_RS05505	COG1061	Type III restriction enzyme res subunit
EKN56_RS05515	COG3081	Nucleoid-associated protein
EKN56_RS05520	COG3082	Protein of unknown function (DUF1414)
EKN56_RS05525	COG3083	sulfuric ester hydrolase activity
EKN56_RS05550	COG2841	Protein conserved in bacteria
EKN56_RS05570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKN56_RS05575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EKN56_RS05600	COG0583	DNA-binding transcription factor activity
EKN56_RS05610	COG0814	amino acid
EKN56_RS05635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EKN56_RS05650	COG1441	menaquinone biosynthetic process
EKN56_RS05655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EKN56_RS05660	COG0596	Alpha beta hydrolase
EKN56_RS05665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EKN56_RS05680	COG1283	sodium-dependent phosphate transmembrane transporter activity
EKN56_RS05690	COG1609	Transcriptional regulator
EKN56_RS05695	COG0477	Major facilitator Superfamily
EKN56_RS05705	COG1169	isochorismate synthase
EKN56_RS05710	COG1007	ATP synthesis coupled electron transport
EKN56_RS05715	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKN56_RS05720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EKN56_RS05725	COG0713	ATP synthesis coupled electron transport
EKN56_RS05730	COG0839	Belongs to the complex I subunit 6 family
EKN56_RS05735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKN56_RS05740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EKN56_RS05745	COG1034	ATP synthesis coupled electron transport
EKN56_RS05755	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EKN56_RS05760	COG0649	NAD binding
EKN56_RS05760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKN56_RS05775	COG3069	C4-dicarboxylate transmembrane transporter activity
EKN56_RS05795	COG0583	DNA-binding transcription factor activity
EKN56_RS05800	COG1114	Component of the transport system for branched-chain amino acids
EKN56_RS05805	COG0436	Aminotransferase
EKN56_RS05810	COG4821	SIS domain
EKN56_RS05820	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EKN56_RS05825	COG5645	(Lipo)protein
EKN56_RS05845	COG2842	Transposition protein
EKN56_RS05960	COG4383	Mu-like prophage protein gp29
EKN56_RS05985	COG4397	Mu-like prophage major head subunit gpT
EKN56_RS06085	COG1785	Belongs to the alkaline phosphatase family
EKN56_RS06090	COG0471	metal ion transport
EKN56_RS06090	COG0490	domain, Protein
EKN56_RS06095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EKN56_RS06100	COG3013	Belongs to the UPF0304 family
EKN56_RS06105	COG3092	negative regulation of chromosome organization
EKN56_RS06110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EKN56_RS06115	COG0857	belongs to the CobB CobQ family
EKN56_RS06115	COG0280	phosphate acetyltransferase
EKN56_RS06120	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EKN56_RS06125	COG0622	Phosphoesterase
EKN56_RS06130	COG0625	glutathione transferase activity
EKN56_RS06135	COG1090	epimerase
EKN56_RS06145	COG1609	Transcriptional regulator
EKN56_RS06150	COG0163	prenyltransferase activity
EKN56_RS06155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EKN56_RS06160	COG1286	toxin biosynthetic process
EKN56_RS06165	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EKN56_RS06170	COG0285	dihydrofolate synthase activity
EKN56_RS06175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EKN56_RS06180	COG0586	Pfam SNARE associated Golgi protein
EKN56_RS06190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EKN56_RS06195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKN56_RS06205	COG1555	photosystem II stabilization
EKN56_RS06210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EKN56_RS06220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EKN56_RS06230	COG0740	serine-type endopeptidase activity
EKN56_RS06235	COG0544	peptidyl-prolyl cis-trans isomerase activity
EKN56_RS06240	COG0271	Belongs to the BolA IbaG family
EKN56_RS06250	COG3056	Lipoprotein
EKN56_RS06255	COG2223	nitrite transmembrane transporter activity
EKN56_RS06380	COG4373	Mu-like prophage FluMu protein gp28
EKN56_RS06515	COG0745	RESPONSE REGULATOR receiver
EKN56_RS06520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EKN56_RS06540	COG1012	belongs to the aldehyde dehydrogenase family
EKN56_RS06540	COG1454	alcohol dehydrogenase
EKN56_RS06545	COG2095	MarC family integral membrane protein
EKN56_RS06555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EKN56_RS06565	COG2350	Protein conserved in bacteria
EKN56_RS06580	COG2917	probably involved in intracellular septation
EKN56_RS06585	COG2084	Dehydrogenase
EKN56_RS06600	COG3047	cAMP biosynthetic process
EKN56_RS06605	COG0248	Ppx GppA phosphatase
EKN56_RS06610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EKN56_RS06620	COG1067	ATP-dependent peptidase activity
EKN56_RS06635	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
EKN56_RS06640	COG3070	regulator of competence-specific genes
EKN56_RS06645	COG1289	transmembrane transporter activity
EKN56_RS06650	COG3304	Inner membrane component domain
EKN56_RS06655	COG0210	DNA helicase
EKN56_RS06660	COG1803	Methylglyoxal synthase
EKN56_RS06665	COG1832	CoA-binding protein
EKN56_RS06725	COG3443	Belongs to the bacterial solute-binding protein 9 family
EKN56_RS06740	COG0730	response to heat
EKN56_RS06745	COG2920	part of a sulfur-relay system
EKN56_RS06750	COG3785	DNA binding
EKN56_RS06755	COG4725	Belongs to the MT-A70-like family
EKN56_RS06765	COG2197	response regulator
EKN56_RS06770	COG0322	excinuclease ABC activity
EKN56_RS06775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EKN56_RS06805	COG0586	Pfam SNARE associated Golgi protein
EKN56_RS06810	COG2195	Cleaves the N-terminal amino acid of tripeptides
EKN56_RS06815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EKN56_RS06835	COG1187	pseudouridine synthase activity
EKN56_RS06840	COG0538	isocitrate dehydrogenase activity
EKN56_RS06870	COG3468	outer membrane autotransporter barrel domain protein
EKN56_RS06880	COG0537	adenosine 5'-monophosphoramidase activity
EKN56_RS06885	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
EKN56_RS06900	COG1252	NADH dehydrogenase
EKN56_RS06905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EKN56_RS06910	COG4591	ABC-type transport system involved in lipoprotein release permease component
EKN56_RS06920	COG4591	ABC-type transport system involved in lipoprotein release permease component
EKN56_RS06955	COG1177	transmembrane transport
EKN56_RS06970	COG2195	Cleaves the N-terminal amino acid of tripeptides
EKN56_RS06975	COG0747	negative chemotaxis
EKN56_RS06980	COG0601	transmembrane transport
EKN56_RS06985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EKN56_RS06990	COG0444	Belongs to the ABC transporter superfamily
EKN56_RS06995	COG4608	Belongs to the ABC transporter superfamily
EKN56_RS07000	COG2850	peptidyl-arginine hydroxylation
EKN56_RS07005	COG0613	PHP domain protein
EKN56_RS07010	COG0009	L-threonylcarbamoyladenylate synthase
EKN56_RS07015	COG1187	pseudouridine synthase activity
EKN56_RS07045	COG3964	amidohydrolase
EKN56_RS07060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKN56_RS07060	COG3711	transcriptional antiterminator
EKN56_RS07065	COG3069	C4-dicarboxylate transmembrane transporter activity
EKN56_RS07070	COG1473	amidohydrolase
EKN56_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS07085	COG0616	signal peptide processing
EKN56_RS07105	COG0583	DNA-binding transcription factor activity
EKN56_RS07115	COG0671	phosphoesterase, PA-phosphatase related
EKN56_RS07120	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EKN56_RS07125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EKN56_RS07130	COG0284	orotidine-5'-phosphate decarboxylase activity
EKN56_RS07135	COG0023	Translation Initiation Factor
EKN56_RS07140	COG1956	GAF domain-containing protein
EKN56_RS07145	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EKN56_RS07155	COG0501	Belongs to the peptidase M48B family
EKN56_RS07165	COG1609	Transcriptional regulator
EKN56_RS07180	COG3001	Fructosamine kinase
EKN56_RS07195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EKN56_RS07200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EKN56_RS07205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EKN56_RS07220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EKN56_RS07225	COG0072	phenylalanine-tRNA ligase activity
EKN56_RS07225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EKN56_RS07230	COG0776	regulation of translation
EKN56_RS07235	COG4139	cobalamin transport
EKN56_RS07375	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EKN56_RS07380	COG0791	NLP P60 protein
EKN56_RS07385	COG2378	regulation of single-species biofilm formation
EKN56_RS07400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EKN56_RS07410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EKN56_RS07410	COG0574	Belongs to the PEP-utilizing enzyme family
EKN56_RS07415	COG0628	permease
EKN56_RS07420	COG0247	lactate metabolic process
EKN56_RS07420	COG0277	FAD linked oxidase domain protein
EKN56_RS07425	COG2050	protein possibly involved in aromatic compounds catabolism
EKN56_RS07445	COG0674	pyruvate-flavodoxin oxidoreductase activity
EKN56_RS07445	COG1013	pyruvate-flavodoxin oxidoreductase activity
EKN56_RS07445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EKN56_RS07445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EKN56_RS07455	COG3187	Heat shock protein
EKN56_RS07460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EKN56_RS07465	COG2911	Protein conserved in bacteria
EKN56_RS07475	COG3784	Protein of unknown function (DUF1318)
EKN56_RS07485	COG1643	Atp-dependent helicase
EKN56_RS07495	COG0531	amino acid
EKN56_RS07505	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EKN56_RS07510	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EKN56_RS07520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKN56_RS07525	COG0672	)-iron permease
EKN56_RS07540	COG1136	(ABC) transporter
EKN56_RS07540	COG0577	efflux transmembrane transporter activity
EKN56_RS07550	COG1136	(ABC) transporter
EKN56_RS07550	COG0577	efflux transmembrane transporter activity
EKN56_RS07555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKN56_RS07560	COG2863	cytochrome
EKN56_RS07585	COG2197	response regulator
EKN56_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKN56_RS07600	COG1132	(ABC) transporter
EKN56_RS07620	COG1538	Outer membrane efflux protein
EKN56_RS07630	COG0826	peptidase U32
EKN56_RS07640	COG2819	hydrolase of the alpha beta superfamily
EKN56_RS07650	COG1280	lysine exporter protein (LysE YggA)
EKN56_RS07670	COG3111	PFAM Bacterial OB fold (BOF) protein
EKN56_RS07695	COG1971	Probably functions as a manganese efflux pump
EKN56_RS07700	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS07710	COG3069	C4-dicarboxylate transmembrane transporter activity
EKN56_RS07715	COG2197	response regulator
EKN56_RS07720	COG0440	acetolactate synthase activity
EKN56_RS07725	COG0028	Belongs to the TPP enzyme family
EKN56_RS07735	COG0589	response to stress
EKN56_RS07755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EKN56_RS07760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EKN56_RS07765	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EKN56_RS07775	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EKN56_RS07795	COG1393	Belongs to the ArsC family
EKN56_RS07800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EKN56_RS07810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EKN56_RS07820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EKN56_RS07830	COG2723	6-phospho-beta-galactosidase activity
EKN56_RS07880	COG4948	Mandelate Racemase Muconate Lactonizing
EKN56_RS07895	COG1902	pentaerythritol trinitrate reductase activity
EKN56_RS07900	COG1309	transcriptional regulator
EKN56_RS07905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EKN56_RS07910	COG1309	transcriptional regulator
EKN56_RS07925	COG0583	DNA-binding transcription factor activity
EKN56_RS07930	COG1902	pentaerythritol trinitrate reductase activity
EKN56_RS07935	COG1335	isochorismatase
EKN56_RS07945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EKN56_RS07990	COG0500	methyltransferase
EKN56_RS07995	COG0157	Belongs to the NadC ModD family
EKN56_RS08040	COG2226	methyltransferase
EKN56_RS08090	COG1422	Protein of unknown function (DUF1090)
EKN56_RS08100	COG4335	DNA alkylation repair
EKN56_RS08105	COG0789	Transcriptional regulator
EKN56_RS08125	COG2226	methyltransferase
EKN56_RS08140	COG1823	symporter activity
EKN56_RS08175	COG4221	oxidoreductase activity
EKN56_RS08180	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EKN56_RS08185	COG1940	carbohydrate kinase activity
EKN56_RS08190	COG2814	Major facilitator Superfamily
EKN56_RS08200	COG1929	Belongs to the glycerate kinase type-1 family
EKN56_RS08205	COG2610	gluconate transmembrane transporter activity
EKN56_RS08210	COG3835	regulator
EKN56_RS08215	COG0114	fumarate hydratase activity
EKN56_RS08220	COG5339	Protein conserved in bacteria
EKN56_RS08225	COG0493	'glutamate synthase
EKN56_RS08225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKN56_RS08230	COG0307	riboflavin synthase, alpha
EKN56_RS08235	COG0534	Mate efflux family protein
EKN56_RS08255	COG4238	major outer membrane lipoprotein
EKN56_RS08260	COG1388	LysM domain
EKN56_RS08260	COG1376	ErfK ybiS ycfS ynhG family protein
EKN56_RS08265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EKN56_RS08275	COG2873	o-acetylhomoserine
EKN56_RS08280	COG3768	UPF0283 membrane protein
EKN56_RS08285	COG3106	COG3106 Predicted ATPase
EKN56_RS08295	COG1983	PspC domain protein
EKN56_RS08305	COG1842	Phage shock protein A
EKN56_RS08310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EKN56_RS08325	COG4171	peptide transport system, permease
EKN56_RS08330	COG4172	Belongs to the ABC transporter superfamily
EKN56_RS08340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EKN56_RS08345	COG3123	guanosine phosphorylase activity
EKN56_RS08350	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EKN56_RS08365	COG1451	nucleotide metabolic process
EKN56_RS08375	COG0494	nUDIX hydrolase
EKN56_RS08380	COG1760	l-serine dehydratase
EKN56_RS08385	COG0668	transmembrane transport
EKN56_RS08390	COG2226	methyltransferase
EKN56_RS08405	COG1560	Kdo2-lipid A biosynthetic process
EKN56_RS08410	COG0385	Bile acid
EKN56_RS08415	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EKN56_RS08440	COG4659	FMN binding
EKN56_RS08450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EKN56_RS08480	COG3895	Periplasmic Protein
EKN56_RS08485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EKN56_RS08495	COG2032	superoxide dismutase activity
EKN56_RS08500	COG3313	Fe-S protein
EKN56_RS08505	COG0346	lactoylglutathione lyase activity
EKN56_RS08510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EKN56_RS08515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EKN56_RS08525	COG1940	carbohydrate kinase activity
EKN56_RS08565	COG0084	hydrolase, TatD family'
EKN56_RS08570	COG0470	DNA polymerase III
EKN56_RS08580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EKN56_RS08585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EKN56_RS08600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EKN56_RS08605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EKN56_RS08610	COG0416	fatty acid biosynthetic process
EKN56_RS08615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EKN56_RS08625	COG0424	maF-like protein
EKN56_RS08630	COG0564	pseudouridine synthase activity
EKN56_RS08635	COG1530	ribonuclease E activity
EKN56_RS08645	COG0513	Belongs to the DEAD box helicase family
EKN56_RS08655	COG0512	Glutamine amidotransferase of anthranilate synthase
EKN56_RS08655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EKN56_RS08660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EKN56_RS08665	COG0134	indole-3-glycerol-phosphate synthase activity
EKN56_RS08665	COG0135	phosphoribosylanthranilate isomerase activity
EKN56_RS08670	COG0133	tryptophan synthase activity
EKN56_RS08675	COG0159	tryptophan synthase activity
EKN56_RS08680	COG5002	protein histidine kinase activity
EKN56_RS08695	COG0419	ATPase involved in DNA repair
EKN56_RS08700	COG2974	May be involved in recombination
EKN56_RS08715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKN56_RS08720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKN56_RS08725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKN56_RS08730	COG2814	Major facilitator Superfamily
EKN56_RS08735	COG2205	protein histidine kinase activity
EKN56_RS08740	COG0745	RESPONSE REGULATOR receiver
EKN56_RS08750	COG0826	peptidase U32
EKN56_RS08760	COG1597	lipid kinase activity
EKN56_RS08765	COG2186	Transcriptional regulator
EKN56_RS08770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EKN56_RS08780	COG2983	Belongs to the UPF0260 family
EKN56_RS08785	COG0179	Fumarylacetoacetate (FAA) hydrolase
EKN56_RS08790	COG2951	lytic endotransglycosylase activity
EKN56_RS08795	COG3100	YcgL domain-containing protein
EKN56_RS08805	COG2894	cell division
EKN56_RS08810	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EKN56_RS08815	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EKN56_RS08820	COG0318	PFAM AMP-dependent synthetase and ligase
EKN56_RS08830	COG1199	ATP-dependent helicase activity
EKN56_RS08835	COG0251	oxidation-reduction process
EKN56_RS08840	COG2076	Multidrug Resistance protein
EKN56_RS08845	COG2076	Multidrug Resistance protein
EKN56_RS08850	COG0800	Aldolase
EKN56_RS08855	COG0363	glucosamine-6-phosphate deaminase activity
EKN56_RS08860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EKN56_RS08865	COG1737	Transcriptional regulator
EKN56_RS08870	COG0469	pyruvate kinase activity
EKN56_RS08875	COG1560	Kdo2-lipid A biosynthetic process
EKN56_RS08880	COG0739	heme binding
EKN56_RS08885	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EKN56_RS08890	COG1121	(ABC) transporter
EKN56_RS08895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EKN56_RS08900	COG2985	domain, Protein
EKN56_RS08900	COG0569	domain protein
EKN56_RS08915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EKN56_RS08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKN56_RS08940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EKN56_RS08945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EKN56_RS08970	COG2255	four-way junction helicase activity
EKN56_RS08975	COG0632	four-way junction helicase activity
EKN56_RS08985	COG0217	transcriptional regulatory protein
EKN56_RS08990	COG0494	nUDIX hydrolase
EKN56_RS08995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EKN56_RS09005	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EKN56_RS09010	COG2226	methyltransferase
EKN56_RS09020	COG0791	NLP P60 protein
EKN56_RS09025	COG2706	6-phosphogluconolactonase activity
EKN56_RS09030	COG3142	Participates in the control of copper homeostasis
EKN56_RS09035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EKN56_RS09040	COG3102	Protein conserved in bacteria
EKN56_RS09045	COG1414	Transcriptional regulator
EKN56_RS09050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKN56_RS09055	COG2207	Transcriptional regulator
EKN56_RS09055	COG3708	Transcriptional regulator
EKN56_RS09080	COG1566	PFAM secretion protein HlyD family protein
EKN56_RS09085	COG1289	transmembrane transporter activity
EKN56_RS09090	COG2271	Major facilitator Superfamily
EKN56_RS09100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKN56_RS09105	COG1414	Transcriptional regulator
EKN56_RS09110	COG3468	outer membrane autotransporter barrel domain protein
EKN56_RS09115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKN56_RS09120	COG3191	aminopeptidase activity
EKN56_RS09135	COG3171	Protein conserved in bacteria
EKN56_RS09140	COG0569	domain protein
EKN56_RS09140	COG2985	domain, Protein
EKN56_RS09155	COG0730	response to heat
EKN56_RS09160	COG0430	RNA-3'-phosphate cyclase activity
EKN56_RS09165	COG1690	Belongs to the RtcB family
EKN56_RS09175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EKN56_RS09180	COG1349	DNA-binding transcription factor activity
EKN56_RS09185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EKN56_RS09190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKN56_RS09195	COG0434	BtpA family
EKN56_RS09200	COG3775	system Galactitol-specific IIC component
EKN56_RS09205	COG3414	Phosphotransferase system galactitol-specific IIB component
EKN56_RS09210	COG1363	Peptidase, m42
EKN56_RS09215	COG4574	serine-type endopeptidase inhibitor activity
EKN56_RS09220	COG0659	secondary active sulfate transmembrane transporter activity
EKN56_RS09225	COG1422	Protein of unknown function (DUF1090)
EKN56_RS09230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EKN56_RS09245	COG2890	protein-(glutamine-N5) methyltransferase activity
EKN56_RS09250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EKN56_RS09255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EKN56_RS09270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EKN56_RS09280	COG0193	aminoacyl-tRNA hydrolase activity
EKN56_RS09285	COG2261	transglycosylase associated protein
EKN56_RS09310	COG0728	peptidoglycan biosynthetic process
EKN56_RS09315	COG3132	Protein of unknown function, DUF480
EKN56_RS09320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKN56_RS09325	COG0477	Major facilitator Superfamily
EKN56_RS09340	COG3381	protein complex oligomerization
EKN56_RS09355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKN56_RS09375	COG0583	DNA-binding transcription factor activity
EKN56_RS09380	COG1027	Aspartate ammonia-lyase
EKN56_RS09385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EKN56_RS09395	COG3005	denitrification pathway
EKN56_RS09400	COG0243	molybdopterin cofactor binding
EKN56_RS09430	COG0012	GTP binding
EKN56_RS09435	COG0582	viral genome integration into host DNA
EKN56_RS09495	COG3121	Chaperone
EKN56_RS09500	COG3188	usher protein
EKN56_RS09505	COG3539	Fimbrial protein
EKN56_RS09510	COG0725	ABC transporter, periplasmic molybdate-binding protein
EKN56_RS09515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EKN56_RS09520	COG3842	ATPase activity
EKN56_RS09530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EKN56_RS09540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EKN56_RS09555	COG1063	alcohol dehydrogenase
EKN56_RS09560	COG1063	alcohol dehydrogenase
EKN56_RS09565	COG0561	phosphatase activity
EKN56_RS09570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EKN56_RS09575	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS09615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EKN56_RS09660	COG1349	DNA-binding transcription factor activity
EKN56_RS09665	COG0446	pyridine nucleotide-disulphide oxidoreductase
EKN56_RS09665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EKN56_RS09675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EKN56_RS09680	COG3192	ethanolamine utilization protein
EKN56_RS09685	COG0477	Major facilitator Superfamily
EKN56_RS09690	COG1957	nucleoside hydrolase
EKN56_RS09695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKN56_RS09710	COG0488	(ABC) transporter
EKN56_RS09715	COG0531	amino acid
EKN56_RS09725	COG1448	Aminotransferase
EKN56_RS09735	COG3916	Acyl-homoserine-lactone synthase
EKN56_RS09745	COG2197	response regulator
EKN56_RS09750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EKN56_RS09755	COG0406	alpha-ribazole phosphatase activity
EKN56_RS09765	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
EKN56_RS09770	COG1942	4-Oxalocrotonate Tautomerase
EKN56_RS09775	COG2720	vancomycin resistance protein
EKN56_RS09800	COG1126	abc transporter atp-binding protein
EKN56_RS09805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKN56_RS09810	COG4215	(ABC) transporter
EKN56_RS09815	COG4160	amino acid transport
EKN56_RS09820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EKN56_RS09830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EKN56_RS09835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EKN56_RS09840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EKN56_RS09845	COG0131	Imidazoleglycerol-phosphate dehydratase
EKN56_RS09845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EKN56_RS09855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EKN56_RS09865	COG0140	phosphoribosyl-ATP diphosphatase activity
EKN56_RS09865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EKN56_RS09880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKN56_RS09885	COG2925	Exonuclease
EKN56_RS09890	COG2962	Rard protein
EKN56_RS09895	COG0531	amino acid
EKN56_RS09900	COG1380	Effector of murein hydrolase LrgA
EKN56_RS09905	COG1346	cytolysis
EKN56_RS09910	COG0281	malic enzyme
EKN56_RS09915	COG2949	membrane
EKN56_RS09920	COG2311	Membrane
EKN56_RS09925	COG0302	gtp cyclohydrolase
EKN56_RS09930	COG0303	'Molybdopterin
EKN56_RS09935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EKN56_RS09940	COG0656	L-ascorbic acid biosynthetic process
EKN56_RS09955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EKN56_RS10010	COG1686	Belongs to the peptidase S11 family
EKN56_RS10015	COG1686	Belongs to the peptidase S11 family
EKN56_RS10020	COG2354	Protein conserved in bacteria
EKN56_RS10030	COG3592	Divergent 4Fe-4S mono-cluster
EKN56_RS10035	COG2388	GCN5-related N-acetyl-transferase
EKN56_RS10040	COG1349	DNA-binding transcription factor activity
EKN56_RS10045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EKN56_RS10060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EKN56_RS10065	COG1523	belongs to the glycosyl hydrolase 13 family
EKN56_RS10070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EKN56_RS10075	COG0297	glycogen (starch) synthase activity
EKN56_RS10080	COG0058	SHG alpha-glucan phosphorylase activity
EKN56_RS10100	COG3708	Transcriptional regulator
EKN56_RS10100	COG2207	Transcriptional regulator
EKN56_RS10110	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EKN56_RS10110	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EKN56_RS10110	COG0506	proline dehydrogenase activity
EKN56_RS10115	COG1414	Transcriptional regulator
EKN56_RS10120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKN56_RS10125	COG0129	dihydroxy-acid dehydratase activity
EKN56_RS10130	COG2271	Major facilitator Superfamily
EKN56_RS10135	COG0371	Dehydrogenase
EKN56_RS10145	COG0488	(ABC) transporter
EKN56_RS10150	COG0513	Belongs to the DEAD box helicase family
EKN56_RS10155	COG0670	Belongs to the BI1 family
EKN56_RS10165	COG0314	molybdopterin synthase activity
EKN56_RS10170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EKN56_RS10175	COG0315	cyclic pyranopterin monophosphate synthase activity
EKN56_RS10180	COG0521	Mo-molybdopterin cofactor biosynthetic process
EKN56_RS10185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EKN56_RS10190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EKN56_RS10200	COG4628	conserved protein (DUF2132)
EKN56_RS10215	COG0556	nucleotide-excision repair
EKN56_RS10220	COG0561	phosphatase activity
EKN56_RS10230	COG4149	molybdate abc transporter
EKN56_RS10235	COG0725	ABC transporter, periplasmic molybdate-binding protein
EKN56_RS10245	COG2005	Transcriptional regulator
EKN56_RS10245	COG3585	molybdate ion transport
EKN56_RS10250	COG0583	DNA-binding transcription factor activity
EKN56_RS10255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EKN56_RS10265	COG2211	Major facilitator Superfamily
EKN56_RS10270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EKN56_RS10275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EKN56_RS10285	COG1119	ATPase activity
EKN56_RS10290	COG1335	isochorismatase
EKN56_RS10295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EKN56_RS10305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EKN56_RS10310	COG2017	converts alpha-aldose to the beta-anomer
EKN56_RS10315	COG0588	phosphoglycerate mutase activity
EKN56_RS10320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EKN56_RS10325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EKN56_RS10330	COG1518	maintenance of DNA repeat elements
EKN56_RS10345	COG1857	crispr-associated protein
EKN56_RS10360	COG1203	CRISPR-associated helicase, Cas3
EKN56_RS10375	COG5301	cellulose 1,4-beta-cellobiosidase activity
EKN56_RS10385	COG3299	homolog of phage Mu protein gp47
EKN56_RS10390	COG4381	Mu-like prophage protein gp46
EKN56_RS10395	COG4384	Bacteriophage Mu Gp45 protein
EKN56_RS10425	COG4386	tail sheath protein
EKN56_RS10440	COG4387	Mu-like prophage protein GP36
EKN56_RS10450	COG4397	Mu-like prophage major head subunit gpT
EKN56_RS10465	COG2369	cell adhesion
EKN56_RS10470	COG4383	Mu-like prophage protein gp29
EKN56_RS10485	COG0640	Transcriptional regulator
EKN56_RS10520	COG5566	PFAM Mor transcription activator
EKN56_RS10570	COG2842	Transposition protein
EKN56_RS10615	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EKN56_RS10620	COG2885	chlorophyll binding
EKN56_RS10625	COG0823	Involved in the tonB-independent uptake of proteins
EKN56_RS10630	COG3064	Membrane
EKN56_RS10635	COG0848	biopolymer transport protein
EKN56_RS10640	COG0811	peptide transport
EKN56_RS10645	COG0824	Thioesterase
EKN56_RS10650	COG3790	cyd operon protein YbgE
EKN56_RS10655	COG4890	Cyd operon protein YbgT
EKN56_RS10660	COG1294	oxidase, subunit
EKN56_RS10665	COG1271	oxidase subunit
EKN56_RS10675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EKN56_RS10685	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKN56_RS10690	COG0567	Dehydrogenase, E1 component
EKN56_RS10700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EKN56_RS10705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EKN56_RS10710	COG3842	ATPase activity
EKN56_RS10720	COG1840	ABC-type Fe3 transport system, periplasmic component
EKN56_RS10725	COG2271	Major facilitator Superfamily
EKN56_RS10730	COG3851	Histidine kinase
EKN56_RS10755	COG0033	Phosphoglucomutase
EKN56_RS10760	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EKN56_RS10780	COG1966	Carbon starvation protein
EKN56_RS10785	COG2879	small protein
EKN56_RS10790	COG0523	cobalamin synthesis protein
EKN56_RS10795	COG0735	belongs to the Fur family
EKN56_RS10805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EKN56_RS10815	COG0363	glucosamine-6-phosphate deaminase activity
EKN56_RS10820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EKN56_RS10825	COG1940	carbohydrate kinase activity
EKN56_RS10825	COG1846	Transcriptional regulator
EKN56_RS10830	COG0367	asparagine synthase
EKN56_RS10870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKN56_RS10885	COG1702	phosphate starvation-inducible protein PhoH
EKN56_RS10895	COG4535	Mg2 and Co2 transporter CorC
EKN56_RS10900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EKN56_RS10910	COG0765	amino acid transport
EKN56_RS10915	COG0765	amino acid transport
EKN56_RS10920	COG1126	abc transporter atp-binding protein
EKN56_RS10930	COG0495	leucyl-tRNA aminoacylation
EKN56_RS10935	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EKN56_RS10940	COG1466	dna polymerase III delta subunit
EKN56_RS10945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EKN56_RS10950	COG0799	negative regulation of ribosome biogenesis
EKN56_RS10960	COG0768	penicillin binding
EKN56_RS10970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EKN56_RS10975	COG1686	Belongs to the peptidase S11 family
EKN56_RS10985	COG2764	glyoxalase bleomycin resistance protein dioxygenase
EKN56_RS10990	COG0321	lipoyl(octanoyl) transferase activity
EKN56_RS10995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EKN56_RS11010	COG2453	phosphatase
EKN56_RS11010	COG0671	phosphoesterase, PA-phosphatase related
EKN56_RS11020	COG2267	carboxylic ester hydrolase activity
EKN56_RS11030	COG4589	Belongs to the CDS family
EKN56_RS11035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EKN56_RS11040	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
EKN56_RS11045	COG1690	Belongs to the RtcB family
EKN56_RS11050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EKN56_RS11060	COG2356	endonuclease I
EKN56_RS11065	COG5645	(Lipo)protein
EKN56_RS11080	COG2372	response to copper ion
EKN56_RS11085	COG1276	copper resistance
EKN56_RS11090	COG3152	Membrane
EKN56_RS11095	COG3145	DNA-N1-methyladenine dioxygenase activity
EKN56_RS11115	COG1278	Cold shock
EKN56_RS11120	COG0656	L-ascorbic acid biosynthetic process
EKN56_RS11155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EKN56_RS11165	COG0251	oxidation-reduction process
EKN56_RS11170	COG3302	dmso reductase anchor subunit
EKN56_RS11175	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS11180	COG0243	molybdopterin cofactor binding
EKN56_RS11190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKN56_RS11195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EKN56_RS11200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EKN56_RS11205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EKN56_RS11210	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EKN56_RS11215	COG4181	ATPase activity
EKN56_RS11220	COG2755	lipolytic protein G-D-S-L family
EKN56_RS11225	COG0300	oxidoreductase activity
EKN56_RS11230	COG3118	belongs to the thioredoxin family
EKN56_RS11235	COG2814	Major facilitator Superfamily
EKN56_RS11240	COG0330	HflC and HflK could
EKN56_RS11245	COG1585	Membrane protein implicated in regulation of membrane protease activity
EKN56_RS11250	COG0789	Transcriptional regulator
EKN56_RS11265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EKN56_RS11280	COG2895	sulfate adenylyltransferase (ATP) activity
EKN56_RS11290	COG1648	precorrin-2 dehydrogenase activity
EKN56_RS11290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EKN56_RS11295	COG0531	amino acid
EKN56_RS11300	COG1982	Orn Lys Arg decarboxylase major
EKN56_RS11310	COG0175	sulfate reduction
EKN56_RS11315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKN56_RS11320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EKN56_RS11330	COG2217	Heavy metal translocating P-type atpase
EKN56_RS11345	COG3716	PTS system mannose fructose sorbose family IID component
EKN56_RS11350	COG3715	PTS system
EKN56_RS11355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EKN56_RS11355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKN56_RS11370	COG3735	TraB family
EKN56_RS11380	COG2223	nitrite transmembrane transporter activity
EKN56_RS11385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EKN56_RS11385	COG4651	solute:proton antiporter activity
EKN56_RS11390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EKN56_RS11400	COG0563	adenylate kinase activity
EKN56_RS11410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EKN56_RS11415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EKN56_RS11430	COG2832	Protein of unknown function (DUF454)
EKN56_RS11435	COG3923	Primosomal replication protein n
EKN56_RS11440	COG2304	oxidoreductase activity
EKN56_RS11450	COG0745	RESPONSE REGULATOR receiver
EKN56_RS11465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EKN56_RS11470	COG1309	transcriptional regulator
EKN56_RS11475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKN56_RS11480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKN56_RS11495	COG2199	diguanylate cyclase activity
EKN56_RS11495	COG2203	Gaf domain
EKN56_RS11530	COG1032	radical SAM domain protein
EKN56_RS11560	COG3695	enzyme binding
EKN56_RS11570	COG1946	Acyl-CoA thioesterase
EKN56_RS11575	COG0814	amino acid
EKN56_RS11580	COG0004	ammonium transporteR
EKN56_RS11585	COG0347	Belongs to the P(II) protein family
EKN56_RS11600	COG1132	(ABC) transporter
EKN56_RS11605	COG1132	(ABC) transporter
EKN56_RS11610	COG1522	sequence-specific DNA binding
EKN56_RS11625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EKN56_RS11630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EKN56_RS11630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EKN56_RS11640	COG3101	peptidyl-lysine hydroxylation
EKN56_RS11645	COG0730	response to heat
EKN56_RS11650	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EKN56_RS11655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EKN56_RS11660	COG2890	protein-(glutamine-N5) methyltransferase activity
EKN56_RS11665	COG2840	Smr protein MutS2
EKN56_RS11685	COG2062	phosphohistidine phosphatase, SixA
EKN56_RS11690	COG3691	Protein conserved in bacteria
EKN56_RS11695	COG2067	long-chain fatty acid transport protein
EKN56_RS11715	COG4235	cytochrome complex assembly
EKN56_RS11715	COG3088	subunit of a heme lyase
EKN56_RS11720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKN56_RS11725	COG1138	Cytochrome C-type biogenesis protein
EKN56_RS11730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EKN56_RS11735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EKN56_RS11740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EKN56_RS11745	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EKN56_RS11785	COG3209	COG3209 Rhs family protein
EKN56_RS11805	COG3501	Rhs element vgr protein
EKN56_RS11855	COG0509	glycine decarboxylation via glycine cleavage system
EKN56_RS11860	COG3501	Rhs element vgr protein
EKN56_RS11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKN56_RS11995	COG2911	Protein conserved in bacteria
EKN56_RS11995	COG3210	domain, Protein
EKN56_RS12000	COG2909	trisaccharide binding
EKN56_RS12005	COG0058	SHG alpha-glucan phosphorylase activity
EKN56_RS12010	COG1640	4-alpha-glucanotransferase
EKN56_RS12020	COG4580	involved in the transport of maltose and maltodextrins
EKN56_RS12030	COG2182	Extracellular solute-binding protein
EKN56_RS12035	COG1175	transmembrane transport
EKN56_RS12040	COG3833	ABC-type maltose transport systems, permease component
EKN56_RS12065	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EKN56_RS12075	COG2137	regulation of response to DNA damage stimulus
EKN56_RS12095	COG0583	DNA-binding transcription factor activity
EKN56_RS12110	COG1737	Transcriptional regulator
EKN56_RS12115	COG2190	(PTS) system
EKN56_RS12115	COG1263	PTS System
EKN56_RS12115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EKN56_RS12120	COG2723	6-phospho-beta-galactosidase activity
EKN56_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS12130	COG2951	lytic endotransglycosylase activity
EKN56_RS12150	COG1940	carbohydrate kinase activity
EKN56_RS12170	COG0583	DNA-binding transcription factor activity
EKN56_RS12180	COG4221	oxidoreductase activity
EKN56_RS12190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EKN56_RS12195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EKN56_RS12220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EKN56_RS12230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EKN56_RS12235	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EKN56_RS12245	COG0585	pseudouridine synthase activity
EKN56_RS12255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EKN56_RS12260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EKN56_RS12270	COG1126	abc transporter atp-binding protein
EKN56_RS12275	COG0765	amino acid transport
EKN56_RS12290	COG0700	Nucleoside recognition
EKN56_RS12305	COG0814	amino acid
EKN56_RS12315	COG0720	synthase
EKN56_RS12320	COG0602	queuosine metabolic process
EKN56_RS12325	COG0148	phosphopyruvate hydratase activity
EKN56_RS12330	COG0504	CTP synthase activity
EKN56_RS12335	COG3956	TIGRFAM MazG family protein
EKN56_RS12340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EKN56_RS12345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EKN56_RS12355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EKN56_RS12365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EKN56_RS12375	COG0571	ribonuclease III activity
EKN56_RS12385	COG0481	GTPase activity
EKN56_RS12395	COG3086	response to oxidative stress
EKN56_RS12400	COG3026	antisigma factor binding
EKN56_RS12405	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
EKN56_RS12415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EKN56_RS12420	COG0513	Belongs to the DEAD box helicase family
EKN56_RS12435	COG1858	cytochrome C peroxidase
EKN56_RS12440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EKN56_RS12445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EKN56_RS12450	COG0497	DNA recombination
EKN56_RS12455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKN56_RS12460	COG2914	Belongs to the UPF0125 (RnfH) family
EKN56_RS12465	COG2867	negative regulation of translational initiation
EKN56_RS12470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EKN56_RS12510	COG0644	oxidoreductase
EKN56_RS12515	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EKN56_RS12520	COG2271	Major facilitator Superfamily
EKN56_RS12545	COG5301	cellulose 1,4-beta-cellobiosidase activity
EKN56_RS12640	COG1802	Transcriptional regulator
EKN56_RS12640	COG4626	Terminase
EKN56_RS12670	COG3772	lysozyme
EKN56_RS12720	COG4197	protein conserved in bacteria, prophage-related
EKN56_RS12800	COG0582	viral genome integration into host DNA
EKN56_RS12805	COG0582	viral genome integration into host DNA
EKN56_RS12850	COG0629	single-stranded DNA binding
EKN56_RS12870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EKN56_RS12990	COG5290	Psort location Cytoplasmic, score
EKN56_RS13065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EKN56_RS13080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EKN56_RS13100	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS13105	COG0243	molybdopterin cofactor binding
EKN56_RS13130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EKN56_RS13155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKN56_RS13185	COG3727	T/G mismatch-specific endonuclease activity
EKN56_RS13195	COG2982	Protein involved in outer membrane biogenesis
EKN56_RS13210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EKN56_RS13215	COG0673	inositol 2-dehydrogenase activity
EKN56_RS13220	COG0534	Mate efflux family protein
EKN56_RS13240	COG1741	Belongs to the pirin family
EKN56_RS13245	COG1566	PFAM secretion protein HlyD family protein
EKN56_RS13250	COG2814	Major facilitator Superfamily
EKN56_RS13255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EKN56_RS13350	COG5301	cellulose 1,4-beta-cellobiosidase activity
EKN56_RS13405	COG1846	Transcriptional regulator
EKN56_RS13410	COG1566	PFAM secretion protein HlyD family protein
EKN56_RS13415	COG2814	Major facilitator Superfamily
EKN56_RS13420	COG1929	Belongs to the glycerate kinase type-1 family
EKN56_RS13425	COG2084	Dehydrogenase
EKN56_RS13435	COG4948	Mandelate Racemase Muconate Lactonizing
EKN56_RS13440	COG4948	Mandelate Racemase Muconate Lactonizing
EKN56_RS13445	COG2271	Major facilitator Superfamily
EKN56_RS13450	COG2721	sulfolactate sulfo-lyase activity
EKN56_RS13455	COG3835	regulator
EKN56_RS13460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EKN56_RS13465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EKN56_RS13475	COG2860	membrane
EKN56_RS13485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EKN56_RS13495	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
EKN56_RS13500	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS13510	COG2414	aldehyde ferredoxin oxidoreductase
EKN56_RS13515	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS13525	COG3112	Uncharacterised protein family (UPF0231)
EKN56_RS13690	COG4695	Portal protein
EKN56_RS13700	COG0464	growth
EKN56_RS13710	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EKN56_RS13760	COG4974	Belongs to the 'phage' integrase family
EKN56_RS13765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKN56_RS13770	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKN56_RS13775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EKN56_RS13780	COG2186	Transcriptional regulator
EKN56_RS13785	COG1113	amino acid transport
EKN56_RS13790	COG3023	N-Acetylmuramoyl-L-alanine amidase
EKN56_RS13795	COG4969	Belongs to the N-Me-Phe pilin family
EKN56_RS13800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EKN56_RS13805	COG1459	type II secretion system
EKN56_RS13810	COG1879	ABC-type sugar transport system periplasmic component
EKN56_RS13815	COG1129	ABC transporter
EKN56_RS13820	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKN56_RS13825	COG1172	Belongs to the binding-protein-dependent transport system permease family
EKN56_RS13830	COG0516	GMP reductase activity
EKN56_RS13840	COG0237	dephospho-CoA kinase activity
EKN56_RS13845	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EKN56_RS13855	COG0494	nUDIX hydrolase
EKN56_RS13860	COG0653	protein targeting
EKN56_RS13875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EKN56_RS13880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EKN56_RS13885	COG0849	cell division
EKN56_RS13890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EKN56_RS13900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EKN56_RS13905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EKN56_RS13910	COG0772	Belongs to the SEDS family
EKN56_RS13925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EKN56_RS13930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EKN56_RS13935	COG0768	penicillin binding
EKN56_RS13940	COG3116	cell division
EKN56_RS13945	COG0275	rRNA processing
EKN56_RS13950	COG2001	Belongs to the MraZ family
EKN56_RS13960	COG0440	acetolactate synthase activity
EKN56_RS13965	COG0028	Belongs to the TPP enzyme family
EKN56_RS13970	COG1022	Amp-dependent synthetase and ligase
EKN56_RS13980	COG3783	Cytochrome b(562)
EKN56_RS13985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EKN56_RS13990	COG0473	3-isopropylmalate dehydrogenase activity
EKN56_RS13995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EKN56_RS14000	COG0066	3-isopropylmalate dehydratase activity
EKN56_RS14005	COG1191	sigma factor activity
EKN56_RS14040	COG1811	Na channel or pump
EKN56_RS14050	COG1178	ABC-type Fe3 transport system permease component
EKN56_RS14060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EKN56_RS14065	COG0417	DNA replication proofreading
EKN56_RS14070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKN56_RS14075	COG0564	pseudouridine synthase activity
EKN56_RS14080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EKN56_RS14085	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EKN56_RS14090	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EKN56_RS14095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EKN56_RS14100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EKN56_RS14105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EKN56_RS14125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EKN56_RS14130	COG3610	response to peptide
EKN56_RS14135	COG2966	Psort location CytoplasmicMembrane, score
EKN56_RS14140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EKN56_RS14150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EKN56_RS14155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EKN56_RS14160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EKN56_RS14170	COG0196	riboflavin kinase activity
EKN56_RS14215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKN56_RS14230	COG1584	GPR1 FUN34 yaaH family protein
EKN56_RS14245	COG0521	Mo-molybdopterin cofactor biosynthetic process
EKN56_RS14250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EKN56_RS14255	COG3022	response to hydroperoxide
EKN56_RS14275	COG0745	RESPONSE REGULATOR receiver
EKN56_RS14280	COG3045	CreA protein
EKN56_RS14285	COG2207	Transcriptional regulator
EKN56_RS14285	COG3708	Transcriptional regulator
EKN56_RS14290	COG0406	alpha-ribazole phosphatase activity
EKN56_RS14315	COG0488	(ABC) transporter
EKN56_RS14320	COG0702	epimerase
EKN56_RS14330	COG0604	alcohol dehydrogenase
EKN56_RS14335	COG0644	oxidoreductase
EKN56_RS14340	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EKN56_RS14345	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EKN56_RS14350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EKN56_RS14355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EKN56_RS14360	COG2086	electron transfer activity
EKN56_RS14365	COG0477	Major facilitator Superfamily
EKN56_RS14370	COG0277	FAD linked oxidase domain protein
EKN56_RS14380	COG2223	nitrite transmembrane transporter activity
EKN56_RS14385	COG1070	Carbohydrate kinase
EKN56_RS14390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EKN56_RS14395	COG0560	Phosphoserine phosphatase
EKN56_RS14400	COG3726	membrane protein affecting hemolysin expression
EKN56_RS14405	COG0084	hydrolase, TatD family'
EKN56_RS14410	COG4667	esterase of the alpha-beta hydrolase superfamily
EKN56_RS14420	COG2823	Periplasmic or secreted lipoprotein
EKN56_RS14425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EKN56_RS14440	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
EKN56_RS14445	COG2813	Specifically methylates the guanine in position
EKN56_RS14450	COG0673	inositol 2-dehydrogenase activity
EKN56_RS14460	COG2731	YhcH YjgK YiaL family protein
EKN56_RS14480	COG4245	von Willebrand factor, type A
EKN56_RS14555	COG1358	cellular component organization or biogenesis
EKN56_RS14565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EKN56_RS14570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EKN56_RS14575	COG3005	denitrification pathway
EKN56_RS14585	COG3381	protein complex oligomerization
EKN56_RS14600	COG2927	DNA polymerase III (CHI subunit)
EKN56_RS14605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EKN56_RS14610	COG0795	lipopolysaccharide-transporting ATPase activity
EKN56_RS14615	COG0795	lipopolysaccharide-transporting ATPase activity
EKN56_RS14645	COG0477	Major facilitator Superfamily
EKN56_RS14650	COG2814	Major facilitator Superfamily
EKN56_RS14670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKN56_RS14675	COG1349	DNA-binding transcription factor activity
EKN56_RS14685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EKN56_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS14710	COG0149	triose-phosphate isomerase activity
EKN56_RS14720	COG3618	amidohydrolase
EKN56_RS14725	COG2271	Major facilitator Superfamily
EKN56_RS14730	COG1461	Dihydroxyacetone kinase
EKN56_RS14735	COG2376	Dihydroxyacetone kinase
EKN56_RS14745	COG2271	Major facilitator Superfamily
EKN56_RS14750	COG2390	Transcriptional regulator
EKN56_RS14755	COG0698	ribose 5-phosphate isomerase
EKN56_RS14760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EKN56_RS14765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EKN56_RS14775	COG2271	Major facilitator Superfamily
EKN56_RS14785	COG0656	L-ascorbic acid biosynthetic process
EKN56_RS14805	COG4869	propanediol catabolic process
EKN56_RS14815	COG0415	Belongs to the DNA photolyase family
EKN56_RS14820	COG3272	Protein of unknown function (DUF1722)
EKN56_RS14825	COG1012	belongs to the aldehyde dehydrogenase family
EKN56_RS14830	COG0583	DNA-binding transcription factor activity
EKN56_RS14855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKN56_RS14860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKN56_RS14870	COG1309	transcriptional regulator
EKN56_RS14875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKN56_RS14915	COG0583	DNA-binding transcription factor activity
EKN56_RS14925	COG3048	D-serine ammonia-lyase activity
EKN56_RS14945	COG3121	Chaperone
EKN56_RS14950	COG3539	Fimbrial protein
EKN56_RS14960	COG3188	usher protein
EKN56_RS14975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKN56_RS14975	COG2205	protein histidine kinase activity
EKN56_RS14980	COG2197	response regulator
EKN56_RS14995	COG2181	nitrate reductase activity
EKN56_RS15000	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EKN56_RS15005	COG1140	nitrate reductase beta subunit
EKN56_RS15010	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EKN56_RS15015	COG2223	nitrite transmembrane transporter activity
EKN56_RS15020	COG3850	Histidine kinase
EKN56_RS15025	COG2197	response regulator
EKN56_RS15035	COG0183	Belongs to the thiolase family
EKN56_RS15040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EKN56_RS15045	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EKN56_RS15060	COG2851	Citrate transporter
EKN56_RS15095	COG0667	Aldo Keto reductase
EKN56_RS15105	COG4221	oxidoreductase activity
EKN56_RS15115	COG0778	Nitroreductase
EKN56_RS15120	COG0583	DNA-binding transcription factor activity
EKN56_RS15165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKN56_RS15180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKN56_RS15185	COG0791	NLP P60 protein
EKN56_RS15205	COG3539	Fimbrial protein
EKN56_RS15230	COG0582	viral genome integration into host DNA
EKN56_RS15240	COG0582	viral genome integration into host DNA
EKN56_RS15275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKN56_RS15280	COG2213	PTS system mannitol-specific
EKN56_RS15280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKN56_RS15285	COG0246	Mannitol dehydrogenase
EKN56_RS15290	COG3722	fumarate hydratase activity
EKN56_RS15295	COG2992	FlgJ-related protein
EKN56_RS15300	COG2211	Major facilitator Superfamily
EKN56_RS15305	COG1397	ADP-ribosylglycohydrolase
EKN56_RS15310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKN56_RS15315	COG2188	Transcriptional regulator
EKN56_RS15325	COG0318	PFAM AMP-dependent synthetase and ligase
EKN56_RS15330	COG0628	permease
EKN56_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
EKN56_RS15365	COG2194	sulfuric ester hydrolase activity
EKN56_RS15370	COG2814	Major facilitator Superfamily
EKN56_RS15370	COG0477	Major facilitator Superfamily
EKN56_RS15375	COG2017	converts alpha-aldose to the beta-anomer
EKN56_RS15380	COG0457	Tetratricopeptide repeat
EKN56_RS15385	COG1940	carbohydrate kinase activity
EKN56_RS15390	COG2771	luxR family
EKN56_RS15400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKN56_RS15405	COG1131	(ABC) transporter
EKN56_RS15410	COG0842	Transport permease protein
EKN56_RS15415	COG0842	Transport permease protein
EKN56_RS15420	COG2132	Multicopper oxidase
EKN56_RS15425	COG0204	Acyl-transferase
EKN56_RS15430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EKN56_RS15440	COG3150	esterase
EKN56_RS15445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EKN56_RS15450	COG3151	Protein conserved in bacteria
EKN56_RS15460	COG0494	nUDIX hydrolase
EKN56_RS15465	COG1538	Outer membrane efflux protein
EKN56_RS15475	COG0754	glutathionylspermidine amidase activity
EKN56_RS15480	COG3384	dioxygenase
EKN56_RS15490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EKN56_RS15500	COG0531	amino acid
EKN56_RS15505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EKN56_RS15505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EKN56_RS15510	COG1560	Kdo2-lipid A biosynthetic process
EKN56_RS15515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EKN56_RS15520	COG3025	triphosphatase activity
EKN56_RS15525	COG4991	sh3 domain protein
EKN56_RS15540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EKN56_RS15545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EKN56_RS15565	COG0358	DNA primase activity
EKN56_RS15620	COG0626	cystathionine gamma-synthase activity
EKN56_RS15635	COG1735	metal-dependent hydrolase with the TIM-barrel fold
EKN56_RS15640	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EKN56_RS15645	COG3457	Alanine racemase
EKN56_RS15655	COG2188	Transcriptional regulator
EKN56_RS15670	COG3381	protein complex oligomerization
EKN56_RS15675	COG3302	dmso reductase anchor subunit
EKN56_RS15680	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS15685	COG0243	molybdopterin cofactor binding
EKN56_RS15710	COG2375	cellular response to nickel ion
EKN56_RS15720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EKN56_RS15725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EKN56_RS15730	COG0586	Pfam SNARE associated Golgi protein
EKN56_RS15735	COG4575	ribosome binding
EKN56_RS15740	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
EKN56_RS15750	COG2259	Doxx family
EKN56_RS15755	COG0435	Glutathione S-transferase
EKN56_RS15770	COG0583	DNA-binding transcription factor activity
EKN56_RS15795	COG1305	Transglutaminase-like
EKN56_RS15805	COG2217	Heavy metal translocating P-type atpase
EKN56_RS15810	COG3005	denitrification pathway
EKN56_RS15815	COG0243	molybdopterin cofactor binding
EKN56_RS15870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EKN56_RS15890	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EKN56_RS15895	COG3107	peptidoglycan biosynthetic process
EKN56_RS15900	COG0792	nuclease activity
EKN56_RS15905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EKN56_RS15910	COG2823	Periplasmic or secreted lipoprotein
EKN56_RS15920	COG0741	lytic transglycosylase activity
EKN56_RS15925	COG3979	chitinase
EKN56_RS15960	COG2165	general secretion pathway protein
EKN56_RS15975	COG1459	type II secretion system
EKN56_RS15980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EKN56_RS15985	COG1450	Type ii and iii secretion system protein
EKN56_RS15990	COG0793	Belongs to the peptidase S41A family
EKN56_RS15995	COG3267	Type II secretory pathway component ExeA
EKN56_RS15995	COG3409	Peptidoglycan-binding domain 1 protein
EKN56_RS16005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EKN56_RS16010	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EKN56_RS16015	COG0784	Response regulator, receiver
EKN56_RS16015	COG5002	protein histidine kinase activity
EKN56_RS16015	COG2198	Histidine kinase
EKN56_RS16020	COG1242	4 iron, 4 sulfur cluster binding
EKN56_RS16025	COG0067	glutamate synthase
EKN56_RS16025	COG0069	glutamate synthase activity
EKN56_RS16025	COG0070	glutamate synthase
EKN56_RS16030	COG0493	'glutamate synthase
EKN56_RS16035	COG0583	DNA-binding transcription factor activity
EKN56_RS16045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EKN56_RS16055	COG2969	positive regulation of protein catabolic process
EKN56_RS16060	COG0625	glutathione transferase activity
EKN56_RS16065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EKN56_RS16080	COG0471	metal ion transport
EKN56_RS16085	COG2828	Protein conserved in bacteria
EKN56_RS16100	COG3051	citrate lyase alpha subunit
EKN56_RS16105	COG2301	Belongs to the HpcH HpaI aldolase family
EKN56_RS16110	COG3052	prosthetic group binding
EKN56_RS16115	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EKN56_RS16120	COG3290	protein histidine kinase activity
EKN56_RS16125	COG4565	transcriptional regulatory protein
EKN56_RS16130	COG3105	Protein conserved in bacteria
EKN56_RS16135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EKN56_RS16145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EKN56_RS16150	COG5007	Belongs to the BolA IbaG family
EKN56_RS16155	COG3113	response to antibiotic
EKN56_RS16160	COG2854	intermembrane phospholipid transfer
EKN56_RS16165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EKN56_RS16170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EKN56_RS16175	COG1127	ABC transporter
EKN56_RS16180	COG0530	calcium, potassium:sodium antiporter activity
EKN56_RS16185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EKN56_RS16185	COG0517	IMP dehydrogenase activity
EKN56_RS16190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EKN56_RS16195	COG3117	lipopolysaccharide transmembrane transporter activity
EKN56_RS16200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EKN56_RS16205	COG1137	ATPase activity
EKN56_RS16210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EKN56_RS16215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKN56_RS16225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EKN56_RS16240	COG0318	PFAM AMP-dependent synthetase and ligase
EKN56_RS16250	COG3848	Pyruvate phosphate dikinase
EKN56_RS16250	COG0574	Belongs to the PEP-utilizing enzyme family
EKN56_RS16265	COG0842	Transport permease protein
EKN56_RS16270	COG1131	(ABC) transporter
EKN56_RS16280	COG0312	modulator of DNA gyrase
EKN56_RS16295	COG1053	succinate dehydrogenase
EKN56_RS16310	COG3604	Transcriptional regulator
EKN56_RS16315	COG2732	(Barnase) inhibitor
EKN56_RS16325	COG3739	integral membrane protein
EKN56_RS16335	COG0312	modulator of DNA gyrase
EKN56_RS16340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKN56_RS16345	COG3164	Protein of unknown function
EKN56_RS16350	COG1530	ribonuclease E activity
EKN56_RS16355	COG0424	maF-like protein
EKN56_RS16365	COG1792	Involved in formation and maintenance of cell shape
EKN56_RS16370	COG1077	Cell shape determining protein MreB Mrl
EKN56_RS16375	COG2200	EAL domain
EKN56_RS16375	COG2199	diguanylate cyclase activity
EKN56_RS16380	COG0604	alcohol dehydrogenase
EKN56_RS16390	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EKN56_RS16395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EKN56_RS16400	COG0511	ligase activity, forming carbon-carbon bonds
EKN56_RS16405	COG0439	Biotin carboxylase
EKN56_RS16410	COG3924	membrane
EKN56_RS16415	COG4145	pantothenate transmembrane transporter activity
EKN56_RS16420	COG2264	protein methyltransferase activity
EKN56_RS16430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EKN56_RS16440	COG1278	Cold shock
EKN56_RS16445	COG0025	NhaP-type Na H and K H
EKN56_RS16450	COG2252	PERMEase
EKN56_RS16470	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EKN56_RS16480	COG2205	protein histidine kinase activity
EKN56_RS16485	COG0745	RESPONSE REGULATOR receiver
EKN56_RS16490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EKN56_RS16530	COG2979	Protein of unknown function (DUF533)
EKN56_RS16535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EKN56_RS16545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EKN56_RS16555	COG2315	Protein conserved in bacteria
EKN56_RS16560	COG1301	dicarboxylic acid transport
EKN56_RS16585	COG0789	Transcriptional regulator
EKN56_RS16590	COG0667	Aldo Keto reductase
EKN56_RS16595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EKN56_RS16600	COG0735	belongs to the Fur family
EKN56_RS16615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EKN56_RS16620	COG2937	Belongs to the GPAT DAPAT family
EKN56_RS16625	COG0644	oxidoreductase
EKN56_RS16640	COG3223	Belongs to the PsiE family
EKN56_RS16655	COG2910	NAD(P)H-binding
EKN56_RS16660	COG0527	aspartate kinase activity
EKN56_RS16670	COG0471	metal ion transport
EKN56_RS16685	COG0640	Transcriptional regulator
EKN56_RS16690	COG0646	methionine synthase
EKN56_RS16690	COG1410	methionine synthase
EKN56_RS16695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EKN56_RS16730	COG3541	Predicted nucleotidyltransferase
EKN56_RS16735	COG4650	regulator
EKN56_RS16740	COG0542	response to heat
EKN56_RS16745	COG1496	oxidoreductase activity
EKN56_RS16750	COG0564	pseudouridine synthase activity
EKN56_RS16755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKN56_RS16760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EKN56_RS16770	COG0336	Belongs to the RNA methyltransferase TrmD family
EKN56_RS16780	COG0228	four-way junction DNA binding
EKN56_RS16785	COG1228	amidohydrolase
EKN56_RS16790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKN56_RS16795	COG1263	PTS System
EKN56_RS16795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EKN56_RS16800	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EKN56_RS16810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EKN56_RS16815	COG4137	Cytochrome C assembly protein
EKN56_RS16820	COG4536	flavin adenine dinucleotide binding
EKN56_RS16830	COG2918	glutathione biosynthetic process
EKN56_RS16835	COG1238	metal cluster binding
EKN56_RS16840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EKN56_RS16850	COG0387	Pfam Sodium calcium exchanger
EKN56_RS16855	COG2130	NADP-dependent
EKN56_RS16860	COG0667	Aldo Keto reductase
EKN56_RS16865	COG1914	H( )-stimulated, divalent metal cation uptake system
EKN56_RS16925	COG3530	Putative quorum-sensing-regulated virulence factor
EKN56_RS16930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EKN56_RS16935	COG3115	cell septum assembly
EKN56_RS16950	COG0110	maltose O-acetyltransferase activity
EKN56_RS16965	COG1216	Glycosyl transferase, family 2
EKN56_RS16965	COG1442	glycosyl transferase family 8
EKN56_RS16985	COG1086	Polysaccharide biosynthesis protein
EKN56_RS17010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKN56_RS17030	COG2205	protein histidine kinase activity
EKN56_RS17035	COG0745	RESPONSE REGULATOR receiver
EKN56_RS17040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKN56_RS17045	COG0577	efflux transmembrane transporter activity
EKN56_RS17045	COG1136	(ABC) transporter
EKN56_RS17050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EKN56_RS17060	COG4208	sulfate ABC transporter
EKN56_RS17065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EKN56_RS17070	COG4150	thiosulfate binding
EKN56_RS17075	COG2837	iron assimilation
EKN56_RS17095	COG3005	denitrification pathway
EKN56_RS17100	COG3043	anaerobic respiration
EKN56_RS17105	COG0348	domain, Protein
EKN56_RS17110	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS17120	COG3062	negative regulation of establishment of protein localization
EKN56_RS17125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKN56_RS17130	COG3850	Histidine kinase
EKN56_RS17135	COG2197	response regulator
EKN56_RS17140	COG1393	Belongs to the ArsC family
EKN56_RS17145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKN56_RS17150	COG1876	peptidase activity
EKN56_RS17160	COG1444	tRNA N-acetyltransferase activity
EKN56_RS17165	COG0583	DNA-binding transcription factor activity
EKN56_RS17170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EKN56_RS17175	COG2207	Transcriptional regulator
EKN56_RS17175	COG3708	Transcriptional regulator
EKN56_RS17180	COG2707	UPF0756 membrane protein
EKN56_RS17185	COG2321	neutral zinc metallopeptidase
EKN56_RS17190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EKN56_RS17195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EKN56_RS17205	COG2716	regulation of RNA biosynthetic process
EKN56_RS17210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EKN56_RS17215	COG0628	permease
EKN56_RS17220	COG4783	chaperone-mediated protein folding
EKN56_RS17225	COG1393	Belongs to the ArsC family
EKN56_RS17235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EKN56_RS17250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EKN56_RS17255	COG2234	aminopeptidase activity
EKN56_RS17265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EKN56_RS17270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKN56_RS17290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EKN56_RS17295	COG0351	phosphomethylpyrimidine kinase
EKN56_RS17300	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EKN56_RS17320	COG1132	(ABC) transporter
EKN56_RS17335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EKN56_RS17340	COG1605	Chorismate mutase
EKN56_RS17340	COG0077	Prephenate dehydratase
EKN56_RS17345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EKN56_RS17350	COG1643	Atp-dependent helicase
EKN56_RS17355	COG1489	DNA binding
EKN56_RS17375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EKN56_RS17380	COG3706	GGDEF domain
EKN56_RS17385	COG0726	polysaccharide deacetylase
EKN56_RS17390	COG3738	Protein conserved in bacteria
EKN56_RS17395	COG0842	Transport permease protein
EKN56_RS17400	COG1131	(ABC) transporter
EKN56_RS17405	COG0288	reversible hydration of carbon dioxide
EKN56_RS17420	COG5441	Belongs to the UPF0261 family
EKN56_RS17425	COG5564	TIM-barrel signal transduction protein
EKN56_RS17445	COG3708	Transcriptional regulator
EKN56_RS17445	COG2207	Transcriptional regulator
EKN56_RS17455	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EKN56_RS17460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EKN56_RS17465	COG1605	Chorismate mutase
EKN56_RS17465	COG0287	Prephenate dehydrogenase
EKN56_RS17470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EKN56_RS17475	COG3279	Response regulator of the LytR AlgR family
EKN56_RS17490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKN56_RS17495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKN56_RS17500	COG0842	Transport permease protein
EKN56_RS17500	COG1129	ABC transporter
EKN56_RS17505	COG0842	Transport permease protein
EKN56_RS17510	COG1876	peptidase activity
EKN56_RS17550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EKN56_RS17550	COG0519	Catalyzes the synthesis of GMP from XMP
EKN56_RS17555	COG0516	GMP reductase activity
EKN56_RS17555	COG0517	IMP dehydrogenase activity
EKN56_RS17560	COG1570	exodeoxyribonuclease VII activity
EKN56_RS17565	COG1645	bacterial-type flagellum-dependent swarming motility
EKN56_RS17580	COG1160	GTP binding
EKN56_RS17585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKN56_RS17590	COG2976	Protein conserved in bacteria
EKN56_RS17600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EKN56_RS17605	COG1426	Protein conserved in bacteria
EKN56_RS17620	COG0105	UTP biosynthetic process
EKN56_RS17625	COG4953	penicillin-binding protein 1C
EKN56_RS17630	COG2373	Large extracellular alpha-helical protein
EKN56_RS17640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EKN56_RS17645	COG2975	iron-sulfur cluster assembly
EKN56_RS17650	COG0633	Ferredoxin
EKN56_RS17655	COG0443	Heat shock 70 kDa protein
EKN56_RS17665	COG0316	Belongs to the HesB IscA family
EKN56_RS17670	COG0822	iron-sulfur transferase activity
EKN56_RS17685	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EKN56_RS17690	COG0483	inositol monophosphate 1-phosphatase activity
EKN56_RS17700	COG0584	glycerophosphoryl diester phosphodiesterase
EKN56_RS17705	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EKN56_RS17710	COG3683	transport system, periplasmic component
EKN56_RS17715	COG1054	Belongs to the UPF0176 family
EKN56_RS17725	COG1017	nitric oxide dioxygenase activity
EKN56_RS17725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EKN56_RS17730	COG0347	Belongs to the P(II) protein family
EKN56_RS17735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EKN56_RS17735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKN56_RS17740	COG2204	response regulator
EKN56_RS17745	COG3170	Tfp pilus assembly protein FimV
EKN56_RS17750	COG2205	protein histidine kinase activity
EKN56_RS17760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EKN56_RS17770	COG0560	Phosphoserine phosphatase
EKN56_RS17785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKN56_RS17790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKN56_RS17795	COG3118	belongs to the thioredoxin family
EKN56_RS17800	COG3148	PFAM DTW domain containing protein
EKN56_RS17805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EKN56_RS17850	COG0151	Belongs to the GarS family
EKN56_RS17865	COG3068	Protein conserved in bacteria
EKN56_RS17870	COG1515	deoxyribonuclease V activity
EKN56_RS17875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EKN56_RS17885	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EKN56_RS17890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EKN56_RS17895	COG0352	thiamine-phosphate diphosphorylase activity
EKN56_RS17900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EKN56_RS17905	COG2104	thiamine diphosphate biosynthetic process
EKN56_RS17910	COG2022	thiamine diphosphate biosynthetic process
EKN56_RS17920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EKN56_RS17930	COG0222	ribosome binding
EKN56_RS17935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EKN56_RS17950	COG0250	Participates in transcription elongation, termination and antitermination
EKN56_RS17960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EKN56_RS17985	COG0747	negative chemotaxis
EKN56_RS17995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EKN56_RS18005	COG3842	ATPase activity
EKN56_RS18010	COG3852	Histidine kinase
EKN56_RS18015	COG2204	response regulator
EKN56_RS18025	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EKN56_RS18030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EKN56_RS18035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EKN56_RS18040	COG2031	fatty acid transporter
EKN56_RS18045	COG0183	Belongs to the thiolase family
EKN56_RS18050	COG4804	nuclease activity
EKN56_RS18055	COG0309	Hydrogenase expression formation protein (HypE)
EKN56_RS18060	COG0409	Hydrogenase expression formation protein
EKN56_RS18065	COG0298	carbon dioxide binding
EKN56_RS18070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EKN56_RS18080	COG1773	rubredoxin
EKN56_RS18085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EKN56_RS18090	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EKN56_RS18095	COG5557	Pfam Polysulphide reductase, NrfD
EKN56_RS18100	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS18105	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EKN56_RS18110	COG1609	Transcriptional regulator
EKN56_RS18115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EKN56_RS18125	COG1053	succinate dehydrogenase
EKN56_RS18130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EKN56_RS18135	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EKN56_RS18140	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EKN56_RS18155	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EKN56_RS18160	COG1072	(Pantothenic acid kinase))
EKN56_RS18175	COG1254	Belongs to the acylphosphatase family
EKN56_RS18200	COG3829	transcription factor binding
EKN56_RS18205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EKN56_RS18210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKN56_RS18215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EKN56_RS18220	COG2271	Major facilitator Superfamily
EKN56_RS18265	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKN56_RS18270	COG0651	ATP synthesis coupled electron transport
EKN56_RS18275	COG0650	Formate hydrogenlyase subunit 4
EKN56_RS18280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EKN56_RS18285	COG4237	Hydrogenase 4 membrane
EKN56_RS18290	COG0651	ATP synthesis coupled electron transport
EKN56_RS18295	COG3261	NADH dehydrogenase
EKN56_RS18295	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EKN56_RS18305	COG3260	NADH ubiquinone oxidoreductase 20
EKN56_RS18315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EKN56_RS18320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKN56_RS18390	COG0551	DNA topoisomerase type I activity
EKN56_RS18395	COG0758	DNA mediated transformation
EKN56_RS18405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EKN56_RS18410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EKN56_RS18410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EKN56_RS18420	COG1970	mechanosensitive ion channel activity
EKN56_RS18425	COG3036	rescue of stalled ribosome
EKN56_RS18430	COG0789	Transcriptional regulator
EKN56_RS18445	COG0202	RNA polymerase activity
EKN56_RS18450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EKN56_RS18455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EKN56_RS18460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EKN56_RS18465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EKN56_RS18470	COG0201	protein transport
EKN56_RS18475	COG0200	Binds to the 23S rRNA
EKN56_RS18480	COG1841	ribosomal large subunit assembly
EKN56_RS18485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EKN56_RS18490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EKN56_RS18495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EKN56_RS18500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EKN56_RS18510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EKN56_RS18535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EKN56_RS18550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EKN56_RS18555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EKN56_RS18560	COG0089	rRNA binding
EKN56_RS18565	COG0088	Forms part of the polypeptide exit tunnel
EKN56_RS18570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EKN56_RS18575	COG0051	transcription antitermination factor activity, RNA binding
EKN56_RS18580	COG1368	sulfuric ester hydrolase activity
EKN56_RS18585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EKN56_RS18590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EKN56_RS18595	COG0049	tRNA binding
EKN56_RS18600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EKN56_RS18620	COG2964	Protein conserved in bacteria
EKN56_RS18625	COG0545	Peptidyl-prolyl cis-trans isomerase
EKN56_RS18630	COG0545	Peptidyl-prolyl cis-trans isomerase
EKN56_RS18635	COG2900	Belongs to the SlyX family
EKN56_RS18640	COG1047	Peptidyl-prolyl cis-trans
EKN56_RS18650	COG2249	NAD(P)H dehydrogenase (quinone) activity
EKN56_RS18655	COG0488	(ABC) transporter
EKN56_RS18665	COG0429	hydrolase of the alpha beta-hydrolase fold
EKN56_RS18670	COG3089	Belongs to the UPF0270 family
EKN56_RS18675	COG3954	Phosphoribulokinase
EKN56_RS18680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKN56_RS18685	COG1289	transmembrane transporter activity
EKN56_RS18695	COG4948	Mandelate Racemase Muconate Lactonizing
EKN56_RS18700	COG1063	alcohol dehydrogenase
EKN56_RS18705	COG0477	Major facilitator Superfamily
EKN56_RS18710	COG0246	Mannitol dehydrogenase
EKN56_RS18730	COG1802	Transcriptional regulator
EKN56_RS18735	COG0433	COG0433 Predicted ATPase
EKN56_RS18755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKN56_RS18760	COG0402	S-adenosylhomocysteine deaminase activity
EKN56_RS18765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EKN56_RS18775	COG0180	Tryptophanyl-tRNA synthetase
EKN56_RS18785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EKN56_RS18800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EKN56_RS18805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EKN56_RS18810	COG4796	Type ii and iii secretion system protein
EKN56_RS18835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EKN56_RS18840	COG0494	nUDIX hydrolase
EKN56_RS18850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EKN56_RS18855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EKN56_RS18875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EKN56_RS18880	COG2183	response to ionizing radiation
EKN56_RS18885	COG1918	ferrous iron import across plasma membrane
EKN56_RS18890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EKN56_RS18915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EKN56_RS18920	COG3134	Outer membrane lipoprotein
EKN56_RS18925	COG1349	DNA-binding transcription factor activity
EKN56_RS18930	COG0705	Rhomboid family
EKN56_RS18945	COG2177	Part of the ABC transporter FtsEX involved in
EKN56_RS18950	COG2884	Cell division ATP-binding protein ftsE
EKN56_RS18955	COG0552	protein localization to endoplasmic reticulum
EKN56_RS18965	COG2814	Major facilitator Superfamily
EKN56_RS18970	COG0742	ribosomal rna small subunit methyltransferase
EKN56_RS18975	COG3776	membrane
EKN56_RS18985	COG3714	YhhN family
EKN56_RS18995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EKN56_RS19005	COG0247	lactate metabolic process
EKN56_RS19015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EKN56_RS19020	COG2271	Major facilitator Superfamily
EKN56_RS19025	COG0584	glycerophosphoryl diester phosphodiesterase
EKN56_RS19035	COG0561	phosphatase activity
EKN56_RS19040	COG2267	carboxylic ester hydrolase activity
EKN56_RS19050	COG1280	lysine exporter protein (LysE YggA)
EKN56_RS19055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EKN56_RS19070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EKN56_RS19090	COG0084	hydrolase, TatD family'
EKN56_RS19095	COG0805	protein transport
EKN56_RS19100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EKN56_RS19105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EKN56_RS19110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EKN56_RS19115	COG3165	ubiquinone biosynthetic process from chorismate
EKN56_RS19140	COG2226	methyltransferase
EKN56_RS19145	COG1322	Protein conserved in bacteria
EKN56_RS19150	COG0586	Pfam SNARE associated Golgi protein
EKN56_RS19155	COG3275	phosphorelay sensor kinase activity
EKN56_RS19160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EKN56_RS19170	COG0583	DNA-binding transcription factor activity
EKN56_RS19185	COG2081	HI0933 family
EKN56_RS19190	COG0306	phosphate transporter
EKN56_RS19195	COG0589	response to stress
EKN56_RS19210	COG0742	ribosomal rna small subunit methyltransferase
EKN56_RS19215	COG0339	signal peptide processing
EKN56_RS19220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKN56_RS19225	COG0625	glutathione transferase activity
EKN56_RS19240	COG2271	Major facilitator Superfamily
EKN56_RS19245	COG0583	DNA-binding transcription factor activity
EKN56_RS19250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EKN56_RS19260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKN56_RS19265	COG1295	ribonuclease BN
EKN56_RS19270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKN56_RS19275	COG0612	Peptidase, M16
EKN56_RS19280	COG1301	dicarboxylic acid transport
EKN56_RS19285	COG2199	diguanylate cyclase activity
EKN56_RS19285	COG2200	EAL domain
EKN56_RS19295	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EKN56_RS19320	COG2194	sulfuric ester hydrolase activity
EKN56_RS19340	COG0149	triose-phosphate isomerase activity
EKN56_RS19360	COG0745	RESPONSE REGULATOR receiver
EKN56_RS19365	COG2205	protein histidine kinase activity
EKN56_RS19370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EKN56_RS19375	COG1045	serine acetyltransferase
EKN56_RS19380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EKN56_RS19385	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EKN56_RS19390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKN56_RS19395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EKN56_RS19400	COG4942	peptidase
EKN56_RS19405	COG2861	carbohydrate metabolic process
EKN56_RS19410	COG0463	Glycosyl transferase, family 2
EKN56_RS19415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EKN56_RS19420	COG0859	PFAM glycosyl transferase family 9
EKN56_RS19425	COG0859	PFAM glycosyl transferase family 9
EKN56_RS19435	COG3307	-O-antigen
EKN56_RS19440	COG1442	glycosyl transferase family 8
EKN56_RS19440	COG1216	Glycosyl transferase, family 2
EKN56_RS19450	COG0438	transferase activity, transferring glycosyl groups
EKN56_RS19455	COG0438	transferase activity, transferring glycosyl groups
EKN56_RS19460	COG1519	Transferase
EKN56_RS19470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EKN56_RS19475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EKN56_RS19485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EKN56_RS19490	COG2003	Belongs to the UPF0758 family
EKN56_RS19495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EKN56_RS19500	COG0756	dUTP diphosphatase activity
EKN56_RS19505	COG1309	transcriptional regulator
EKN56_RS19525	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EKN56_RS19525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EKN56_RS19530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EKN56_RS19565	COG3254	rhamnose metabolic process
EKN56_RS19570	COG0235	Class ii aldolase
EKN56_RS19580	COG1070	Carbohydrate kinase
EKN56_RS19585	COG1917	Cupin 2, conserved barrel domain protein
EKN56_RS19585	COG2169	Transcriptional regulator
EKN56_RS19590	COG4977	sequence-specific DNA binding
EKN56_RS19590	COG1917	Cupin 2, conserved barrel domain protein
EKN56_RS19645	COG3708	Transcriptional regulator
EKN56_RS19645	COG2207	Transcriptional regulator
EKN56_RS19665	COG4386	tail sheath protein
EKN56_RS19710	COG4626	Terminase
EKN56_RS19710	COG1802	Transcriptional regulator
EKN56_RS19755	COG3477	response to acidic pH
EKN56_RS19830	COG3311	Transcriptional regulator
EKN56_RS19840	COG0582	viral genome integration into host DNA
EKN56_RS19845	COG2207	Transcriptional regulator
EKN56_RS19845	COG1609	Transcriptional regulator
EKN56_RS19850	COG4214	carbohydrate transport
EKN56_RS19855	COG1129	ABC transporter
EKN56_RS19860	COG4213	ABC transporter substrate-binding protein
EKN56_RS19865	COG2115	Belongs to the xylose isomerase family
EKN56_RS19870	COG1070	Carbohydrate kinase
EKN56_RS19880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EKN56_RS19890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EKN56_RS19895	COG0066	3-isopropylmalate dehydratase activity
EKN56_RS19900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EKN56_RS19900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EKN56_RS19905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EKN56_RS19915	COG2079	MmgE PrpD family protein
EKN56_RS19920	COG3069	C4-dicarboxylate transmembrane transporter activity
EKN56_RS19925	COG4948	Mandelate Racemase Muconate Lactonizing
EKN56_RS19930	COG0583	DNA-binding transcription factor activity
EKN56_RS19940	COG3276	selenocysteine insertion sequence binding
EKN56_RS19945	COG1921	L-seryl-tRNASec selenium transferase activity
EKN56_RS19950	COG1064	alcohol dehydrogenase
EKN56_RS19955	COG1840	ABC-type Fe3 transport system, periplasmic component
EKN56_RS19965	COG3842	ATPase activity
EKN56_RS19975	COG3058	Necessary for formate dehydrogenase activity
EKN56_RS19980	COG2864	formate dehydrogenase
EKN56_RS19985	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS20050	COG2814	Major facilitator Superfamily
EKN56_RS20055	COG0813	purine-nucleoside phosphorylase activity
EKN56_RS20060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EKN56_RS20065	COG1349	DNA-binding transcription factor activity
EKN56_RS20070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EKN56_RS20075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EKN56_RS20080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EKN56_RS20095	COG2824	Alkylphosphonate utilization operon protein PhnA
EKN56_RS20100	COG2258	MOSC domain
EKN56_RS20105	COG2186	Transcriptional regulator
EKN56_RS20110	COG3734	2-keto-3-deoxy-galactonokinase
EKN56_RS20115	COG0800	Aldolase
EKN56_RS20120	COG2271	Major facilitator Superfamily
EKN56_RS20125	COG0129	dihydroxy-acid dehydratase activity
EKN56_RS20130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKN56_RS20150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EKN56_RS20155	COG3084	Protein conserved in bacteria
EKN56_RS20160	COG4235	cytochrome complex assembly
EKN56_RS20165	COG4235	cytochrome complex assembly
EKN56_RS20165	COG3088	subunit of a heme lyase
EKN56_RS20175	COG1138	Cytochrome C-type biogenesis protein
EKN56_RS20180	COG3301	Polysulphide reductase, NrfD
EKN56_RS20185	COG0437	4 iron, 4 sulfur cluster binding
EKN56_RS20190	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EKN56_RS20200	COG0746	molybdenum cofactor guanylyltransferase activity
EKN56_RS20205	COG1763	Mo-molybdopterin cofactor biosynthetic process
EKN56_RS20235	COG0765	amino acid transport
EKN56_RS20245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKN56_RS20260	COG3720	iron ion transport
EKN56_RS20265	COG4558	Periplasmic binding protein
EKN56_RS20270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKN56_RS20275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EKN56_RS20280	COG0704	Plays a role in the regulation of phosphate uptake
EKN56_RS20290	COG0581	inorganic phosphate transmembrane transporter activity
EKN56_RS20295	COG0573	inorganic phosphate transmembrane transporter activity
EKN56_RS20300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EKN56_RS20305	COG0366	Alpha amylase catalytic
EKN56_RS20315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EKN56_RS20335	COG1090	epimerase
EKN56_RS20350	COG0583	DNA-binding transcription factor activity
EKN56_RS20375	COG3034	peptidoglycan biosynthetic process
EKN56_RS20380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EKN56_RS20385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EKN56_RS20390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EKN56_RS20405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EKN56_RS20415	COG0356	it plays a direct role in the translocation of protons across the membrane
EKN56_RS20420	COG3312	ion transport
EKN56_RS20425	COG0357	Ribosomal RNA small subunit methyltransferase G
EKN56_RS20430	COG0445	tRNA wobble uridine modification
EKN56_RS20435	COG0716	FMN binding
EKN56_RS20440	COG1522	sequence-specific DNA binding
EKN56_RS20450	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EKN56_RS20465	COG0477	Major facilitator Superfamily
EKN56_RS20470	COG2186	Transcriptional regulator
EKN56_RS20475	COG2814	Major facilitator Superfamily
EKN56_RS20480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EKN56_RS20485	COG2252	PERMEase
EKN56_RS20520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EKN56_RS20560	COG1216	Glycosyl transferase, family 2
EKN56_RS20565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EKN56_RS20570	COG0204	Acyl-transferase
EKN56_RS20570	COG0318	PFAM AMP-dependent synthetase and ligase
EKN56_RS20580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EKN56_RS20585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EKN56_RS20590	COG0204	Acyl-transferase
EKN56_RS20610	COG0542	response to heat
EKN56_RS20635	COG3642	lipopolysaccharide core region biosynthetic process
EKN56_RS20665	COG1704	LemA family
EKN56_RS20675	COG0405	Gamma-glutamyltransferase
EKN56_RS20685	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EKN56_RS20715	COG1473	amidohydrolase
EKN56_RS20720	COG0477	Major facilitator Superfamily
EKN56_RS20730	COG1297	OPT oligopeptide transporter protein
EKN56_RS20780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EKN56_RS20785	COG0706	membrane insertase activity
EKN56_RS20790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EKN56_RS20795	COG0594	ribonuclease P activity