locus-tag	class	description
CEP80_RS00010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEP80_RS00025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEP80_RS00030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CEP80_RS00035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEP80_RS00045	COG0195	Participates in both transcription termination and antitermination
CEP80_RS00050	COG0779	Required for maturation of 30S ribosomal subunits
CEP80_RS00060	COG0442	prolyl-tRNA aminoacylation
CEP80_RS00070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CEP80_RS00075	COG0750	zinc metalloprotease
CEP80_RS00080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CEP80_RS00090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEP80_RS00095	COG0575	Belongs to the CDS family
CEP80_RS00100	COG0233	cytoplasmic translational termination
CEP80_RS00110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEP80_RS00115	COG0052	Belongs to the universal ribosomal protein uS2 family
CEP80_RS00125	COG1191	sigma factor activity
CEP80_RS00140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CEP80_RS00170	COG0792	nuclease activity
CEP80_RS00180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEP80_RS00185	COG0681	Belongs to the peptidase S26 family
CEP80_RS00190	COG0335	large ribosomal subunit rRNA binding
CEP80_RS00195	COG0336	Belongs to the RNA methyltransferase TrmD family
CEP80_RS00200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEP80_RS00205	COG1837	Belongs to the UPF0109 family
CEP80_RS00210	COG0228	four-way junction DNA binding
CEP80_RS00225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CEP80_RS00255	COG0105	UTP biosynthetic process
CEP80_RS00265	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CEP80_RS00270	COG1461	Dihydroxyacetone kinase
CEP80_RS00275	COG2376	Dihydroxyacetone kinase
CEP80_RS00280	COG0285	dihydrofolate synthase activity
CEP80_RS00285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CEP80_RS00295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CEP80_RS00305	COG4139	cobalamin transport
CEP80_RS00310	COG1120	ATPase activity
CEP80_RS00315	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CEP80_RS00315	COG0778	Nitroreductase
CEP80_RS00330	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CEP80_RS00335	COG0765	amino acid transport
CEP80_RS00345	COG1605	Chorismate mutase
CEP80_RS00345	COG0077	Prephenate dehydratase
CEP80_RS00350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEP80_RS00355	COG0740	serine-type endopeptidase activity
CEP80_RS00360	COG0740	serine-type endopeptidase activity
CEP80_RS00365	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEP80_RS00380	COG1045	serine acetyltransferase
CEP80_RS00385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEP80_RS00390	COG4552	Acetyltransferase involved in intracellular survival and related
CEP80_RS00400	COG0698	ribose 5-phosphate isomerase
CEP80_RS00405	COG3590	peptidase
CEP80_RS00415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CEP80_RS00435	COG0668	transmembrane transport
CEP80_RS00445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEP80_RS00450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEP80_RS00455	COG2346	COG2346, Truncated hemoglobins
CEP80_RS00490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEP80_RS00505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CEP80_RS00510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CEP80_RS00545	COG2217	Heavy metal translocating P-type atpase
CEP80_RS00550	COG1937	Protein conserved in bacteria
CEP80_RS00560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEP80_RS00605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CEP80_RS00615	COG0328	RNA-DNA hybrid ribonuclease activity
CEP80_RS00630	COG0009	L-threonylcarbamoyladenylate synthase
CEP80_RS00635	COG0783	Belongs to the Dps family
CEP80_RS00660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEP80_RS00680	COG0135	phosphoribosylanthranilate isomerase activity
CEP80_RS00685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEP80_RS00695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEP80_RS00705	COG0488	(ABC) transporter
CEP80_RS00715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEP80_RS00725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEP80_RS00735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CEP80_RS00745	COG1061	Type III restriction enzyme res subunit
CEP80_RS00815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CEP80_RS00825	COG2177	Part of the ABC transporter FtsEX involved in
CEP80_RS00830	COG2884	Cell division ATP-binding protein ftsE
CEP80_RS00835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CEP80_RS00875	COG2814	Major facilitator Superfamily
CEP80_RS00885	COG2135	peptidase activity
CEP80_RS00900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEP80_RS00925	COG0424	maF-like protein
CEP80_RS00930	COG4770	biotin carboxylase activity
CEP80_RS00940	COG2089	acid synthase
CEP80_RS00985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEP80_RS00995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CEP80_RS01000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEP80_RS01020	COG1079	Belongs to the binding-protein-dependent transport system permease family
CEP80_RS01025	COG4603	Belongs to the binding-protein-dependent transport system permease family
CEP80_RS01030	COG3845	ABC transporter
CEP80_RS01035	COG1744	ABC transporter substrate-binding protein PnrA-like
CEP80_RS01040	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CEP80_RS01040	COG1473	amidohydrolase
CEP80_RS01045	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CEP80_RS01045	COG0662	Cupin 2, conserved barrel domain protein
CEP80_RS01050	COG2009	succinate dehydrogenase
CEP80_RS01060	COG1053	succinate dehydrogenase
CEP80_RS01065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEP80_RS01080	COG0180	Tryptophanyl-tRNA synthetase
CEP80_RS01090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEP80_RS01100	COG1595	DNA-templated transcription, initiation
CEP80_RS01110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEP80_RS01120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEP80_RS01125	COG1611	Belongs to the LOG family
CEP80_RS01130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEP80_RS01160	COG0287	Prephenate dehydrogenase
CEP80_RS01175	COG2720	vancomycin resistance protein
CEP80_RS01185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CEP80_RS01190	COG1217	gtp-binding protein TYPA
CEP80_RS01200	COG1136	(ABC) transporter
CEP80_RS01200	COG0577	efflux transmembrane transporter activity
CEP80_RS01220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEP80_RS01235	COG1063	alcohol dehydrogenase
CEP80_RS01265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEP80_RS01375	COG1136	(ABC) transporter
CEP80_RS01395	COG0596	Alpha beta hydrolase
CEP80_RS01410	COG0012	GTP binding
CEP80_RS01415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEP80_RS01420	COG1570	exodeoxyribonuclease VII activity
CEP80_RS01425	COG1722	exodeoxyribonuclease VII activity
CEP80_RS01430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEP80_RS01440	COG0114	fumarate hydratase activity
CEP80_RS01445	COG1846	Transcriptional regulator
CEP80_RS01450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CEP80_RS01460	COG0589	response to stress
CEP80_RS01465	COG1609	Transcriptional regulator
CEP80_RS01480	COG5297	Belongs to the glycosyl hydrolase family 6
CEP80_RS01520	COG0640	Transcriptional regulator
CEP80_RS01540	COG1615	UPF0182 protein
CEP80_RS01550	COG3480	Lon protease (S16) C-terminal proteolytic domain
CEP80_RS01580	COG0210	DNA helicase
CEP80_RS01620	COG0513	Belongs to the DEAD box helicase family
CEP80_RS01630	COG2095	MarC family integral membrane protein
CEP80_RS01640	COG0006	proline dipeptidase activity
CEP80_RS01650	COG2239	Acts as a magnesium transporter
CEP80_RS01665	COG0708	Exodeoxyribonuclease III
CEP80_RS01675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEP80_RS01680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEP80_RS01710	COG0039	L-malate dehydrogenase activity
CEP80_RS01715	COG1511	domain protein
CEP80_RS01735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CEP80_RS01740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEP80_RS01740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEP80_RS01760	COG0138	bifunctional purine biosynthesis protein purh
CEP80_RS01795	COG0058	SHG alpha-glucan phosphorylase activity
CEP80_RS01800	COG0840	transmembrane signaling receptor activity
CEP80_RS01810	COG0045	succinate-CoA ligase (ADP-forming) activity
CEP80_RS01820	COG1126	abc transporter atp-binding protein
CEP80_RS01825	COG0765	amino acid transport
CEP80_RS01830	COG0765	amino acid transport
CEP80_RS01835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEP80_RS01855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEP80_RS01860	COG0175	sulfate reduction
CEP80_RS01875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEP80_RS01875	COG1648	precorrin-2 dehydrogenase activity
CEP80_RS01885	COG2197	response regulator
CEP80_RS01915	COG0519	Catalyzes the synthesis of GMP from XMP
CEP80_RS01915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEP80_RS01930	COG1132	(ABC) transporter
CEP80_RS01935	COG1132	(ABC) transporter
CEP80_RS01955	COG0516	GMP reductase activity
CEP80_RS01965	COG0564	pseudouridine synthase activity
CEP80_RS01985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEP80_RS01995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CEP80_RS02000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEP80_RS02010	COG0456	acetyltransferase
CEP80_RS02020	COG0802	atpase or kinase
CEP80_RS02025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEP80_RS02035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEP80_RS02040	COG0736	holo-[acyl-carrier-protein] synthase activity
CEP80_RS02045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CEP80_RS02050	COG1072	(Pantothenic acid kinase))
CEP80_RS02060	COG0242	peptide deformylase activity
CEP80_RS02065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEP80_RS02070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CEP80_RS02075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEP80_RS02085	COG1054	Belongs to the UPF0176 family
CEP80_RS02090	COG0101	tRNA pseudouridine synthase activity
CEP80_RS02095	COG0203	ribosomal protein L17
CEP80_RS02100	COG0202	RNA polymerase activity
CEP80_RS02105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEP80_RS02110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEP80_RS02115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEP80_RS02120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEP80_RS02125	COG0563	adenylate kinase activity
CEP80_RS02135	COG0200	Binds to the 23S rRNA
CEP80_RS02140	COG1841	ribosomal large subunit assembly
CEP80_RS02145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEP80_RS02150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CEP80_RS02155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEP80_RS02160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEP80_RS02165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEP80_RS02170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEP80_RS02175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEP80_RS02180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CEP80_RS02185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEP80_RS02190	COG0255	Belongs to the universal ribosomal protein uL29 family
CEP80_RS02195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEP80_RS02200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CEP80_RS02205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CEP80_RS02210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEP80_RS02215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEP80_RS02220	COG0089	rRNA binding
CEP80_RS02225	COG0088	Forms part of the polypeptide exit tunnel
CEP80_RS02230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEP80_RS02235	COG0051	transcription antitermination factor activity, RNA binding
CEP80_RS02240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEP80_RS02245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEP80_RS02250	COG0049	tRNA binding
CEP80_RS02255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CEP80_RS02260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEP80_RS02265	COG0085	RNA polymerase activity
CEP80_RS02270	COG0222	ribosome binding
CEP80_RS02275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEP80_RS02280	COG0081	regulation of translation
CEP80_RS02285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CEP80_RS02290	COG0250	Participates in transcription elongation, termination and antitermination
CEP80_RS02315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEP80_RS02325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEP80_RS02340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEP80_RS02345	COG0738	Major facilitator superfamily
CEP80_RS02355	COG1609	Transcriptional regulator
CEP80_RS02365	COG2030	dehydratase
CEP80_RS02370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEP80_RS02390	COG1666	GTP binding
CEP80_RS02395	COG0561	phosphatase activity
CEP80_RS02405	COG0501	Belongs to the peptidase M48B family
CEP80_RS02410	COG0493	'glutamate synthase
CEP80_RS02430	COG0142	geranyltranstransferase activity
CEP80_RS02435	COG1007	ATP synthesis coupled electron transport
CEP80_RS02445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEP80_RS02450	COG0713	ATP synthesis coupled electron transport
CEP80_RS02455	COG0839	Belongs to the complex I subunit 6 family
CEP80_RS02460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEP80_RS02465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CEP80_RS02470	COG1034	ATP synthesis coupled electron transport
CEP80_RS02475	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CEP80_RS02485	COG0649	NAD binding
CEP80_RS02495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEP80_RS02510	COG2226	methyltransferase
CEP80_RS02515	COG1169	isochorismate synthase
CEP80_RS02520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEP80_RS02525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CEP80_RS02530	COG4948	Mandelate Racemase Muconate Lactonizing
CEP80_RS02540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CEP80_RS02575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEP80_RS02580	COG1333	cytochrome c biogenesis protein
CEP80_RS02585	COG0785	Cytochrome C biogenesis protein
CEP80_RS02595	COG0406	alpha-ribazole phosphatase activity
CEP80_RS02620	COG3534	alpha-L-arabinofuranosidase
CEP80_RS02635	COG1175	transmembrane transport
CEP80_RS02640	COG0395	ABC-type sugar transport system, permease component
CEP80_RS02655	COG1609	Transcriptional regulator
CEP80_RS02665	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEP80_RS02670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEP80_RS02675	COG0569	domain protein
CEP80_RS02680	COG4214	carbohydrate transport
CEP80_RS02690	COG4213	ABC transporter substrate-binding protein
CEP80_RS02695	COG3940	Belongs to the glycosyl hydrolase 43 family
CEP80_RS02700	COG4213	ABC transporter substrate-binding protein
CEP80_RS02705	COG2160	L-arabinose isomerase activity
CEP80_RS02720	COG1609	Transcriptional regulator
CEP80_RS02735	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CEP80_RS02750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CEP80_RS02765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CEP80_RS02770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEP80_RS02785	COG2409	Drug exporters of the RND superfamily
CEP80_RS02795	COG0577	efflux transmembrane transporter activity
CEP80_RS02795	COG1136	(ABC) transporter
CEP80_RS02800	COG0577	efflux transmembrane transporter activity
CEP80_RS02800	COG1136	(ABC) transporter
CEP80_RS02825	COG0702	epimerase
CEP80_RS02860	COG1070	Carbohydrate kinase
CEP80_RS02865	COG2115	Belongs to the xylose isomerase family
CEP80_RS02880	COG0667	Aldo Keto reductase
CEP80_RS02895	COG0714	Associated with various cellular activities
CEP80_RS02910	COG1716	ATPase activity
CEP80_RS02930	COG2188	Transcriptional regulator
CEP80_RS02940	COG0640	Transcriptional regulator
CEP80_RS02955	COG0438	transferase activity, transferring glycosyl groups
CEP80_RS02960	COG1490	D-aminoacyl-tRNA deacylase activity
CEP80_RS02970	COG4129	membrane
CEP80_RS02980	COG3485	protocatechuate 3,4-dioxygenase
CEP80_RS02995	COG0745	RESPONSE REGULATOR receiver
CEP80_RS03000	COG0596	Alpha beta hydrolase
CEP80_RS03030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEP80_RS03065	COG1120	ATPase activity
CEP80_RS03070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEP80_RS03075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEP80_RS03085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEP80_RS03110	COG1131	(ABC) transporter
CEP80_RS03125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEP80_RS03135	COG2011	ABC-type metal ion transport system permease component
CEP80_RS03140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEP80_RS03145	COG1464	Belongs to the NlpA lipoprotein family
CEP80_RS03195	COG3145	DNA-N1-methyladenine dioxygenase activity
CEP80_RS03215	COG2233	PERMEase
CEP80_RS03275	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CEP80_RS03285	COG2149	membrane
CEP80_RS03290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEP80_RS03300	COG0395	ABC-type sugar transport system, permease component
CEP80_RS03305	COG1175	transmembrane transport
CEP80_RS03320	COG1136	(ABC) transporter
CEP80_RS03320	COG0577	efflux transmembrane transporter activity
CEP80_RS03355	COG0798	PFAM Bile acid sodium symporter
CEP80_RS03360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEP80_RS03365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEP80_RS03400	COG2357	RelA SpoT domain protein
CEP80_RS03415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEP80_RS03420	COG0745	RESPONSE REGULATOR receiver
CEP80_RS03435	COG0789	Transcriptional regulator
CEP80_RS03440	COG0484	heat shock protein binding
CEP80_RS03450	COG0443	Heat shock 70 kDa protein
CEP80_RS03465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEP80_RS03475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CEP80_RS03480	COG0142	geranyltranstransferase activity
CEP80_RS03515	COG2409	Drug exporters of the RND superfamily
CEP80_RS03520	COG1764	response to oxidative stress
CEP80_RS03575	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CEP80_RS03590	COG1253	flavin adenine dinucleotide binding
CEP80_RS03605	COG3842	ATPase activity
CEP80_RS03610	COG4149	molybdate abc transporter
CEP80_RS03640	COG1175	transmembrane transport
CEP80_RS03645	COG0395	ABC-type sugar transport system, permease component
CEP80_RS03655	COG2514	catechol 2,3-dioxygenase activity
CEP80_RS03680	COG1278	Cold shock
CEP80_RS03690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEP80_RS03695	COG1121	(ABC) transporter
CEP80_RS03700	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEP80_RS03725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEP80_RS03730	COG0586	Pfam SNARE associated Golgi protein
CEP80_RS03740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEP80_RS03770	COG2315	Protein conserved in bacteria
CEP80_RS03775	COG3764	Sortase (surface protein transpeptidase)
CEP80_RS03830	COG2018	Roadblock/LC7 domain
CEP80_RS03835	COG0840	transmembrane signaling receptor activity
CEP80_RS03845	COG0395	ABC-type sugar transport system, permease component
CEP80_RS03850	COG1175	transmembrane transport
CEP80_RS03855	COG1653	transport
CEP80_RS03860	COG0561	phosphatase activity
CEP80_RS03865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CEP80_RS03870	COG1597	lipid kinase activity
CEP80_RS03885	COG2267	carboxylic ester hydrolase activity
CEP80_RS03890	COG1215	transferase activity, transferring glycosyl groups
CEP80_RS03935	COG0733	neurotransmitter:sodium symporter activity
CEP80_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
CEP80_RS03970	COG4172	Belongs to the ABC transporter superfamily
CEP80_RS03975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEP80_RS03985	COG0747	negative chemotaxis
CEP80_RS03990	COG1643	Atp-dependent helicase
CEP80_RS03995	COG3189	MarR family transcriptional regulator
CEP80_RS04000	COG1846	Transcriptional regulator
CEP80_RS04000	COG1940	carbohydrate kinase activity
CEP80_RS04010	COG0395	ABC-type sugar transport system, permease component
CEP80_RS04015	COG1175	transmembrane transport
CEP80_RS04035	COG1162	GTPase activity
CEP80_RS04050	COG4555	ABC transporter
CEP80_RS04065	COG0402	S-adenosylhomocysteine deaminase activity
CEP80_RS04090	COG1136	(ABC) transporter
CEP80_RS04105	COG3401	FG-GAP repeat protein
CEP80_RS04110	COG3573	Dehydrogenase
CEP80_RS04135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEP80_RS04195	COG0477	Major facilitator Superfamily
CEP80_RS04205	COG1132	(ABC) transporter
CEP80_RS04210	COG1132	(ABC) transporter
CEP80_RS04220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEP80_RS04240	COG0351	phosphomethylpyrimidine kinase
CEP80_RS04245	COG1082	Xylose isomerase domain protein TIM barrel
CEP80_RS04255	COG0494	nUDIX hydrolase
CEP80_RS04265	COG0436	Aminotransferase
CEP80_RS04275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEP80_RS04300	COG1716	ATPase activity
CEP80_RS04315	COG0768	penicillin binding
CEP80_RS04320	COG0515	serine threonine protein kinase
CEP80_RS04350	COG0705	Rhomboid family
CEP80_RS04385	COG0583	DNA-binding transcription factor activity
CEP80_RS04390	COG2094	Belongs to the DNA glycosylase MPG family
CEP80_RS04400	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEP80_RS04405	COG1937	Protein conserved in bacteria
CEP80_RS04425	COG2132	Multicopper oxidase
CEP80_RS04435	COG1253	flavin adenine dinucleotide binding
CEP80_RS04445	COG2235	arginine
CEP80_RS04465	COG1053	succinate dehydrogenase
CEP80_RS04470	COG0726	polysaccharide deacetylase
CEP80_RS04500	COG1131	(ABC) transporter
CEP80_RS04515	COG1122	ATPase activity
CEP80_RS04535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEP80_RS04540	COG0676	glucose-6-phosphate 1-epimerase activity
CEP80_RS04545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEP80_RS04565	COG1902	pentaerythritol trinitrate reductase activity
CEP80_RS04570	COG0519	Catalyzes the synthesis of GMP from XMP
CEP80_RS04570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEP80_RS04580	COG2197	response regulator
CEP80_RS04585	COG4585	Histidine kinase
CEP80_RS04595	COG1131	(ABC) transporter
CEP80_RS04600	COG1064	alcohol dehydrogenase
CEP80_RS04605	COG2814	Major facilitator Superfamily
CEP80_RS04610	COG0583	DNA-binding transcription factor activity
CEP80_RS04625	COG0577	efflux transmembrane transporter activity
CEP80_RS04625	COG1136	(ABC) transporter
CEP80_RS04630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEP80_RS04645	COG2130	NADP-dependent
CEP80_RS04670	COG1609	Transcriptional regulator
CEP80_RS04680	COG0702	epimerase
CEP80_RS04685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEP80_RS04700	COG0425	Belongs to the sulfur carrier protein TusA family
CEP80_RS04705	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CEP80_RS04720	COG1122	ATPase activity
CEP80_RS04735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CEP80_RS04740	COG0534	Mate efflux family protein
CEP80_RS04775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CEP80_RS04780	COG0659	secondary active sulfate transmembrane transporter activity
CEP80_RS04810	COG0435	Glutathione S-transferase
CEP80_RS04830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEP80_RS04835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEP80_RS04840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEP80_RS04845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP80_RS04845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEP80_RS04860	COG1349	DNA-binding transcription factor activity
CEP80_RS04895	COG2855	membrane
CEP80_RS04910	COG0477	Major facilitator Superfamily
CEP80_RS04925	COG0535	radical SAM domain protein
CEP80_RS04930	COG4335	DNA alkylation repair
CEP80_RS04945	COG3177	Filamentation induced by cAMP protein fic
CEP80_RS04950	COG1136	(ABC) transporter
CEP80_RS04950	COG0577	efflux transmembrane transporter activity
CEP80_RS04980	COG0489	protein tyrosine kinase activity
CEP80_RS04980	COG3206	protein involved in exopolysaccharide biosynthesis
CEP80_RS04985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEP80_RS05000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CEP80_RS05010	COG2244	polysaccharide biosynthetic process
CEP80_RS05035	COG2409	Drug exporters of the RND superfamily
CEP80_RS05055	COG0028	Belongs to the TPP enzyme family
CEP80_RS05070	COG1780	Probably involved in ribonucleotide reductase function
CEP80_RS05085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEP80_RS05085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEP80_RS05100	COG1322	Protein conserved in bacteria
CEP80_RS05105	COG1131	(ABC) transporter
CEP80_RS05110	COG3559	Exporter of polyketide antibiotics
CEP80_RS05145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEP80_RS05150	COG0187	DNA topoisomerase II activity
CEP80_RS05155	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CEP80_RS05160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEP80_RS05165	COG0592	DNA-directed DNA polymerase activity
CEP80_RS05170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEP80_RS05175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CEP80_RS05180	COG0594	ribonuclease P activity
CEP80_RS05185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CEP80_RS05190	COG0706	membrane insertase activity
CEP80_RS05200	COG0357	Ribosomal RNA small subunit methyltransferase G
CEP80_RS05205	COG1192	Involved in chromosome partitioning
CEP80_RS05215	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEP80_RS05225	COG3118	belongs to the thioredoxin family
CEP80_RS05230	COG0492	ferredoxin-NADP+ reductase activity
CEP80_RS05255	COG0617	tRNA 3'-terminal CCA addition
CEP80_RS05270	COG0488	(ABC) transporter
CEP80_RS05275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CEP80_RS05280	COG0019	diaminopimelate decarboxylase activity
CEP80_RS05285	COG1215	transferase activity, transferring glycosyl groups
CEP80_RS05295	COG1472	Belongs to the glycosyl hydrolase 3 family
CEP80_RS05325	COG1260	myo-inositol-1-phosphate synthase
CEP80_RS05335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEP80_RS05340	COG0360	Binds together with S18 to 16S ribosomal RNA
CEP80_RS05350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CEP80_RS05355	COG0359	binds to the 23S rRNA
CEP80_RS05370	COG0305	Participates in initiation and elongation during chromosome replication
CEP80_RS05395	COG2197	response regulator
CEP80_RS05400	COG4585	Histidine kinase
CEP80_RS05405	COG1131	(ABC) transporter
CEP80_RS05425	COG2813	Specifically methylates the guanine in position
CEP80_RS05455	COG2372	response to copper ion
CEP80_RS05470	COG1937	Protein conserved in bacteria
CEP80_RS05490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CEP80_RS05505	COG0181	hydroxymethylbilane synthase activity
CEP80_RS05510	COG1674	ftsk spoiiie
CEP80_RS05540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEP80_RS05545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CEP80_RS05560	COG3655	Transcriptional regulator
CEP80_RS05565	COG1609	Transcriptional regulator
CEP80_RS05575	COG0386	Belongs to the glutathione peroxidase family
CEP80_RS05585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEP80_RS05610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEP80_RS05615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEP80_RS05620	COG1950	PFAM Membrane protein of
CEP80_RS05630	COG0022	dehydrogenase e1 component
CEP80_RS05635	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEP80_RS05640	COG0659	secondary active sulfate transmembrane transporter activity
CEP80_RS05675	COG1132	(ABC) transporter
CEP80_RS05705	COG2340	Cysteine-rich secretory protein family
CEP80_RS05715	COG0714	Associated with various cellular activities
CEP80_RS05760	COG0717	Belongs to the dCTP deaminase family
CEP80_RS05770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEP80_RS05770	COG2111	Na H antiporter
CEP80_RS05775	COG1006	Multisubunit Na H antiporter MnhC subunit
CEP80_RS05780	COG0651	ATP synthesis coupled electron transport
CEP80_RS05795	COG1320	monovalent cation:proton antiporter activity
CEP80_RS05825	COG3103	Sh3 type 3 domain protein
CEP80_RS05825	COG1388	LysM domain
CEP80_RS05825	COG0791	NLP P60 protein
CEP80_RS05840	COG0300	oxidoreductase activity
CEP80_RS05845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEP80_RS05870	COG1366	Belongs to the anti-sigma-factor antagonist family
CEP80_RS05885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEP80_RS05890	COG1609	Transcriptional regulator
CEP80_RS05900	COG0151	Belongs to the GarS family
CEP80_RS05905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEP80_RS05910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEP80_RS05915	COG0047	phosphoribosylformylglycinamidine synthase activity
CEP80_RS05945	COG3265	gluconokinase activity
CEP80_RS05950	COG4948	Mandelate Racemase Muconate Lactonizing
CEP80_RS05955	COG0246	Mannitol dehydrogenase
CEP80_RS05960	COG1904	glucuronate isomerase
CEP80_RS05965	COG1609	Transcriptional regulator
CEP80_RS05980	COG4209	transmembrane transport
CEP80_RS05985	COG0395	ABC-type sugar transport system, permease component
CEP80_RS06060	COG2072	flavoprotein involved in K transport
CEP80_RS06085	COG2030	dehydratase
CEP80_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
CEP80_RS06095	COG0183	Belongs to the thiolase family
CEP80_RS06135	COG4604	ABC transporter, ATP-binding protein
CEP80_RS06140	COG4605	iron ion homeostasis
CEP80_RS06145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEP80_RS06150	COG4607	ABC-type enterochelin transport system periplasmic component
CEP80_RS06160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEP80_RS06170	COG2223	nitrite transmembrane transporter activity
CEP80_RS06175	COG0243	molybdopterin cofactor binding
CEP80_RS06180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEP80_RS06185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CEP80_RS06195	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CEP80_RS06200	COG4208	sulfate ABC transporter
CEP80_RS06225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEP80_RS06265	COG5002	protein histidine kinase activity
CEP80_RS06290	COG2608	mercury ion transmembrane transporter activity
CEP80_RS06305	COG4974	Belongs to the 'phage' integrase family
CEP80_RS06485	COG0305	Participates in initiation and elongation during chromosome replication
CEP80_RS06530	COG0629	single-stranded DNA binding
CEP80_RS06595	COG4974	Belongs to the 'phage' integrase family
CEP80_RS06775	COG0305	Participates in initiation and elongation during chromosome replication
CEP80_RS06820	COG0629	single-stranded DNA binding
CEP80_RS06910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEP80_RS06920	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CEP80_RS06925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEP80_RS06955	COG1174	glycine betaine transport
CEP80_RS06960	COG1125	glycine betaine transport
CEP80_RS06960	COG0517	IMP dehydrogenase activity
CEP80_RS06965	COG1316	TRANSCRIPTIONal
CEP80_RS06970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEP80_RS06990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CEP80_RS07005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CEP80_RS07030	COG0584	glycerophosphoryl diester phosphodiesterase
CEP80_RS07040	COG0395	ABC-type sugar transport system, permease component
CEP80_RS07055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEP80_RS07080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CEP80_RS07085	COG0456	acetyltransferase
CEP80_RS07090	COG0840	transmembrane signaling receptor activity
CEP80_RS07105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEP80_RS07115	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CEP80_RS07120	COG2116	formate transmembrane transporter activity
CEP80_RS07165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEP80_RS07170	COG1111	helicase
CEP80_RS07170	COG1205	dead DEAH box helicase
CEP80_RS07200	COG0456	acetyltransferase
CEP80_RS07215	COG1940	carbohydrate kinase activity
CEP80_RS07225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CEP80_RS07235	COG0800	Aldolase
CEP80_RS07240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEP80_RS07260	COG2890	protein-(glutamine-N5) methyltransferase activity
CEP80_RS07275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEP80_RS07275	COG2146	nitrite reductase [NAD(P)H] activity
CEP80_RS07280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEP80_RS07280	COG1648	precorrin-2 dehydrogenase activity
CEP80_RS07295	COG1754	DNA topoisomerase type I activity
CEP80_RS07295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEP80_RS07310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEP80_RS07315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CEP80_RS07355	COG1876	peptidase activity
CEP80_RS07490	COG0305	Participates in initiation and elongation during chromosome replication
CEP80_RS07535	COG0629	single-stranded DNA binding
CEP80_RS07650	COG1136	(ABC) transporter
CEP80_RS07655	COG0247	lactate metabolic process
CEP80_RS07655	COG0277	FAD linked oxidase domain protein
CEP80_RS07680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CEP80_RS07685	COG2873	o-acetylhomoserine
CEP80_RS07695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CEP80_RS07710	COG0037	tRNA processing
CEP80_RS07720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEP80_RS07725	COG0302	gtp cyclohydrolase
CEP80_RS07730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEP80_RS07735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEP80_RS07760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEP80_RS07765	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CEP80_RS07770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CEP80_RS07780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CEP80_RS07800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEP80_RS07805	COG0297	glycogen (starch) synthase activity
CEP80_RS07810	COG0588	phosphoglycerate mutase activity
CEP80_RS07820	COG5002	protein histidine kinase activity
CEP80_RS07825	COG0745	RESPONSE REGULATOR receiver
CEP80_RS07845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEP80_RS07865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEP80_RS07865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CEP80_RS07870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEP80_RS07885	COG1175	transmembrane transport
CEP80_RS07890	COG0395	ABC-type sugar transport system, permease component
CEP80_RS07895	COG1472	Belongs to the glycosyl hydrolase 3 family
CEP80_RS07900	COG0215	cysteine-tRNA ligase activity
CEP80_RS07905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEP80_RS07915	COG3842	ATPase activity
CEP80_RS07970	COG0459	protein refolding
CEP80_RS07985	COG2205	protein histidine kinase activity
CEP80_RS07990	COG0745	RESPONSE REGULATOR receiver
CEP80_RS08000	COG1061	Type III restriction enzyme res subunit
CEP80_RS08010	COG1278	Cold shock
CEP80_RS08025	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CEP80_RS08040	COG1256	bacterial-type flagellum assembly
CEP80_RS08040	COG4786	Flagellar basal body rod
CEP80_RS08050	COG1191	sigma factor activity
CEP80_RS08055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEP80_RS08060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEP80_RS08065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEP80_RS08070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEP80_RS08075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CEP80_RS08090	COG1815	bacterial-type flagellum-dependent cell motility
CEP80_RS08100	COG1677	Flagellar hook-basal body complex protein FliE
CEP80_RS08105	COG1766	The M ring may be actively involved in energy transduction
CEP80_RS08110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEP80_RS08120	COG1157	protein secretion by the type III secretion system
CEP80_RS08130	COG1388	LysM domain
CEP80_RS08130	COG0791	NLP P60 protein
CEP80_RS08165	COG1360	Flagellar Motor Protein
CEP80_RS08195	COG1987	bacterial-type flagellum assembly
CEP80_RS08205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEP80_RS08210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEP80_RS08225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CEP80_RS08230	COG0643	Histidine kinase
CEP80_RS08230	COG0784	Response regulator, receiver
CEP80_RS08230	COG2198	Histidine kinase
CEP80_RS08240	COG2201	protein-glutamate methylesterase activity
CEP80_RS08245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CEP80_RS08250	COG0745	RESPONSE REGULATOR receiver
CEP80_RS08260	COG0745	RESPONSE REGULATOR receiver
CEP80_RS08270	COG2252	PERMEase
CEP80_RS08280	COG1482	cell wall glycoprotein biosynthetic process
CEP80_RS08290	COG2814	Major facilitator Superfamily
CEP80_RS08355	COG4824	toxin secretion phage lysis holin
CEP80_RS08375	COG1970	mechanosensitive ion channel activity
CEP80_RS08410	COG1012	belongs to the aldehyde dehydrogenase family
CEP80_RS08415	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CEP80_RS08425	COG1132	(ABC) transporter
CEP80_RS08430	COG0840	transmembrane signaling receptor activity
CEP80_RS08435	COG4213	ABC transporter substrate-binding protein
CEP80_RS08440	COG1335	isochorismatase
CEP80_RS08450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEP80_RS08455	COG0084	hydrolase, TatD family'
CEP80_RS08460	COG3583	domain protein
CEP80_RS08470	COG3583	domain protein
CEP80_RS08480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CEP80_RS08490	COG0488	(ABC) transporter
CEP80_RS08495	COG1846	Transcriptional regulator
CEP80_RS08505	COG2186	Transcriptional regulator
CEP80_RS08510	COG1668	transmembrane transport
CEP80_RS08515	COG4152	abc transporter atp-binding protein
CEP80_RS08520	COG1309	transcriptional regulator
CEP80_RS08530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEP80_RS08540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEP80_RS08545	COG0193	aminoacyl-tRNA hydrolase activity
CEP80_RS08560	COG0129	dihydroxy-acid dehydratase activity
CEP80_RS08570	COG1690	Belongs to the RtcB family
CEP80_RS08585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEP80_RS08590	COG0444	Belongs to the ABC transporter superfamily
CEP80_RS08600	COG3507	Belongs to the glycosyl hydrolase 43 family
CEP80_RS08620	COG0148	phosphopyruvate hydratase activity
CEP80_RS08640	COG1252	NADH dehydrogenase
CEP80_RS08650	COG1320	monovalent cation:proton antiporter activity
CEP80_RS08655	COG2212	antiporter activity
CEP80_RS08665	COG0651	ATP synthesis coupled electron transport
CEP80_RS08670	COG1006	Multisubunit Na H antiporter MnhC subunit
CEP80_RS08675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEP80_RS08675	COG2111	Na H antiporter
CEP80_RS08690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEP80_RS08695	COG1120	ATPase activity
CEP80_RS08700	COG2239	Acts as a magnesium transporter
CEP80_RS08725	COG2755	lipolytic protein G-D-S-L family
CEP80_RS08725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CEP80_RS08730	COG0693	protein deglycase activity
CEP80_RS08755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEP80_RS08765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEP80_RS08770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEP80_RS08780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CEP80_RS08800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEP80_RS08805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CEP80_RS08835	COG0395	ABC-type sugar transport system, permease component
CEP80_RS08865	COG1136	(ABC) transporter
CEP80_RS08865	COG0577	efflux transmembrane transporter activity
CEP80_RS08870	COG2197	response regulator
CEP80_RS08875	COG4585	Histidine kinase
CEP80_RS08880	COG0745	RESPONSE REGULATOR receiver
CEP80_RS08885	COG2205	protein histidine kinase activity
CEP80_RS08905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEP80_RS08910	COG1316	TRANSCRIPTIONal
CEP80_RS08915	COG1316	TRANSCRIPTIONal
CEP80_RS08955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEP80_RS08985	COG3594	Acyltransferase
CEP80_RS09000	COG1442	glycosyl transferase family 8
CEP80_RS09000	COG1216	Glycosyl transferase, family 2
CEP80_RS09010	COG1134	teichoic acid transport
CEP80_RS09045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CEP80_RS09070	COG0714	Associated with various cellular activities
CEP80_RS09090	COG0745	RESPONSE REGULATOR receiver
CEP80_RS09095	COG5002	protein histidine kinase activity
CEP80_RS09100	COG5401	PFAM Sporulation and spore germination
CEP80_RS09110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEP80_RS09115	COG0653	protein targeting
CEP80_RS09155	COG0483	inositol monophosphate 1-phosphatase activity
CEP80_RS09165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CEP80_RS09175	COG1595	DNA-templated transcription, initiation
CEP80_RS09195	COG0567	Dehydrogenase, E1 component
CEP80_RS09195	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEP80_RS09205	COG1131	(ABC) transporter
CEP80_RS09210	COG2205	protein histidine kinase activity
CEP80_RS09215	COG0745	RESPONSE REGULATOR receiver
CEP80_RS09235	COG1454	alcohol dehydrogenase
CEP80_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
CEP80_RS09265	COG0018	arginyl-trna synthetase
CEP80_RS09270	COG0019	diaminopimelate decarboxylase activity
CEP80_RS09280	COG0460	homoserine dehydrogenase
CEP80_RS09285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CEP80_RS09290	COG0083	homoserine kinase activity
CEP80_RS09300	COG0254	rRNA binding
CEP80_RS09305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEP80_RS09310	COG2890	protein-(glutamine-N5) methyltransferase activity
CEP80_RS09320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEP80_RS09330	COG0356	it plays a direct role in the translocation of protons across the membrane
CEP80_RS09345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEP80_RS09350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEP80_RS09355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEP80_RS09360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEP80_RS09365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEP80_RS09375	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CEP80_RS09380	COG1472	Belongs to the glycosyl hydrolase 3 family
CEP80_RS09390	COG4209	transmembrane transport
CEP80_RS09395	COG0395	ABC-type sugar transport system, permease component
CEP80_RS09400	COG1609	Transcriptional regulator
CEP80_RS09415	COG1501	Belongs to the glycosyl hydrolase 31 family
CEP80_RS09425	COG3458	cephalosporin-C deacetylase activity
CEP80_RS09430	COG1940	carbohydrate kinase activity
CEP80_RS09440	COG1175	transmembrane transport
CEP80_RS09445	COG0395	ABC-type sugar transport system, permease component
CEP80_RS09470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEP80_RS09475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEP80_RS09490	COG1196	nuclear chromosome segregation
CEP80_RS09500	COG1136	(ABC) transporter
CEP80_RS09500	COG0577	efflux transmembrane transporter activity
CEP80_RS09525	COG0024	Methionine aminopeptidase
CEP80_RS09530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CEP80_RS09535	COG0545	Peptidyl-prolyl cis-trans isomerase
CEP80_RS09545	COG0596	Alpha beta hydrolase
CEP80_RS09575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CEP80_RS09585	COG0366	Alpha amylase catalytic
CEP80_RS09600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CEP80_RS09615	COG0482	sulfurtransferase activity
CEP80_RS09635	COG1505	serine-type exopeptidase activity
CEP80_RS09640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEP80_RS09660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEP80_RS09665	COG0154	amidase activity
CEP80_RS09670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEP80_RS09680	COG0129	dihydroxy-acid dehydratase activity
CEP80_RS09690	COG0440	acetolactate synthase activity
CEP80_RS09695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEP80_RS09710	COG1131	(ABC) transporter
CEP80_RS09715	COG0473	3-isopropylmalate dehydrogenase activity
CEP80_RS09720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEP80_RS09725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEP80_RS09745	COG3304	Inner membrane component domain
CEP80_RS09755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEP80_RS09765	COG1115	amino acid carrier protein
CEP80_RS09780	COG0667	Aldo Keto reductase
CEP80_RS09790	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEP80_RS09795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEP80_RS09820	COG1414	Transcriptional regulator
CEP80_RS09825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CEP80_RS09830	COG0066	3-isopropylmalate dehydratase activity
CEP80_RS09835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEP80_RS09845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEP80_RS09850	COG0626	cystathionine gamma-synthase activity
CEP80_RS09855	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEP80_RS09875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEP80_RS09885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEP80_RS09890	COG0742	ribosomal rna small subunit methyltransferase
CEP80_RS09900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEP80_RS09915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CEP80_RS09925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEP80_RS09935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEP80_RS09940	COG2161	toxin-antitoxin pair type II binding
CEP80_RS09945	COG4115	mRNA cleavage
CEP80_RS09965	COG4585	Histidine kinase
CEP80_RS09970	COG1132	(ABC) transporter
CEP80_RS09975	COG4988	ABC transporter
CEP80_RS09980	COG1294	oxidase, subunit
CEP80_RS09985	COG1271	oxidase subunit
CEP80_RS09990	COG1530	ribonuclease E activity
CEP80_RS09995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEP80_RS10000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEP80_RS10005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEP80_RS10010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CEP80_RS10025	COG0076	glutamate decarboxylase activity
CEP80_RS10030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CEP80_RS10035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CEP80_RS10045	COG0799	negative regulation of ribosome biogenesis
CEP80_RS10050	COG0406	alpha-ribazole phosphatase activity
CEP80_RS10070	COG1362	aminopeptidase activity
CEP80_RS10115	COG0647	UMP catabolic process
CEP80_RS10140	COG3507	Belongs to the glycosyl hydrolase 43 family
CEP80_RS10145	COG3507	Belongs to the glycosyl hydrolase 43 family
CEP80_RS10175	COG2354	Protein conserved in bacteria
CEP80_RS10200	COG0517	IMP dehydrogenase activity
CEP80_RS10200	COG4175	Glycine betaine
CEP80_RS10205	COG4176	ABC-type proline glycine betaine transport system permease component
CEP80_RS10215	COG0686	Belongs to the AlaDH PNT family
CEP80_RS10225	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEP80_RS10230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEP80_RS10240	COG4585	Histidine kinase
CEP80_RS10250	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CEP80_RS10260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEP80_RS10280	COG1126	abc transporter atp-binding protein
CEP80_RS10285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEP80_RS10290	COG0765	amino acid transport
CEP80_RS10295	COG0765	amino acid transport
CEP80_RS10305	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CEP80_RS10325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CEP80_RS10330	COG3387	PFAM Glycoside hydrolase 15-related
CEP80_RS10345	COG3012	SEC-C Motif Domain Protein
CEP80_RS10350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEP80_RS10360	COG0400	carboxylic ester hydrolase activity
CEP80_RS10375	COG2860	membrane
CEP80_RS10390	COG0579	oxidoreductase
CEP80_RS10405	COG2814	Major facilitator Superfamily
CEP80_RS10435	COG1307	EDD domain protein, DegV family
CEP80_RS10460	COG1131	(ABC) transporter
CEP80_RS10470	COG0268	Binds directly to 16S ribosomal RNA
CEP80_RS10480	COG0481	GTPase activity
CEP80_RS10490	COG5473	translation initiation factor activity
CEP80_RS10500	COG1420	regulation of RNA biosynthetic process
CEP80_RS10505	COG0484	heat shock protein binding
CEP80_RS10515	COG0537	adenosine 5'-monophosphoramidase activity
CEP80_RS10525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEP80_RS10535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEP80_RS10550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEP80_RS10555	COG1381	Involved in DNA repair and RecF pathway recombination
CEP80_RS10560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEP80_RS10575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEP80_RS10580	COG1121	(ABC) transporter
CEP80_RS10585	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEP80_RS10590	COG0423	glycine-tRNA ligase activity
CEP80_RS10605	COG0366	Alpha amylase catalytic
CEP80_RS10610	COG1609	Transcriptional regulator
CEP80_RS10625	COG3833	ABC-type maltose transport systems, permease component
CEP80_RS10640	COG0358	DNA primase activity
CEP80_RS10680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEP80_RS10685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEP80_RS10705	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CEP80_RS10720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CEP80_RS10725	COG1309	transcriptional regulator
CEP80_RS10775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CEP80_RS10785	COG3022	response to hydroperoxide
CEP80_RS10820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CEP80_RS10825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEP80_RS10825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CEP80_RS10830	COG0174	glutamine synthetase
CEP80_RS10835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CEP80_RS10840	COG0628	permease
CEP80_RS10845	COG0174	glutamine synthetase
CEP80_RS10860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEP80_RS10865	COG0321	lipoyl(octanoyl) transferase activity
CEP80_RS10870	COG0673	inositol 2-dehydrogenase activity
CEP80_RS10885	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEP80_RS10890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEP80_RS10925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEP80_RS10940	COG0167	dihydroorotate dehydrogenase activity
CEP80_RS10945	COG0667	Aldo Keto reductase
CEP80_RS10965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CEP80_RS10980	COG0425	Belongs to the sulfur carrier protein TusA family
CEP80_RS10990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CEP80_RS10995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEP80_RS11010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CEP80_RS11015	COG0723	plastoquinol--plastocyanin reductase activity
CEP80_RS11020	COG2010	Cytochrome c
CEP80_RS11025	COG1845	cytochrome c oxidase, subunit III
CEP80_RS11035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEP80_RS11050	COG1940	carbohydrate kinase activity
CEP80_RS11070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CEP80_RS11085	COG0515	serine threonine protein kinase
CEP80_RS11085	COG2815	serine threonine protein kinase
CEP80_RS11095	COG0142	geranyltranstransferase activity
CEP80_RS11105	COG0589	response to stress
CEP80_RS11110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEP80_RS11120	COG0187	DNA topoisomerase II activity
CEP80_RS11155	COG1410	methionine synthase
CEP80_RS11155	COG0646	methionine synthase
CEP80_RS11160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEP80_RS11195	COG0756	dUTP diphosphatase activity
CEP80_RS11220	COG0569	domain protein
CEP80_RS11225	COG0531	amino acid
CEP80_RS11235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CEP80_RS11270	COG1024	Enoyl-CoA hydratase
CEP80_RS11270	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEP80_RS11275	COG0183	Belongs to the thiolase family
CEP80_RS11285	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CEP80_RS11330	COG0512	Glutamine amidotransferase of anthranilate synthase
CEP80_RS11330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEP80_RS11370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CEP80_RS11380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEP80_RS11385	COG1560	Kdo2-lipid A biosynthetic process
CEP80_RS11390	COG0438	transferase activity, transferring glycosyl groups
CEP80_RS11400	COG0494	nUDIX hydrolase
CEP80_RS11405	COG0217	transcriptional regulatory protein
CEP80_RS11410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CEP80_RS11415	COG0632	four-way junction helicase activity
CEP80_RS11420	COG2255	four-way junction helicase activity
CEP80_RS11430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEP80_RS11435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEP80_RS11440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEP80_RS11445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEP80_RS11455	COG1196	nuclear chromosome segregation
CEP80_RS11465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEP80_RS11485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEP80_RS11500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEP80_RS11505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEP80_RS11515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEP80_RS11520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEP80_RS11530	COG1459	type II secretion system
CEP80_RS11555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CEP80_RS11560	COG1077	Cell shape determining protein MreB Mrl
CEP80_RS11575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEP80_RS11580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEP80_RS11585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEP80_RS11590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CEP80_RS11610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEP80_RS11615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEP80_RS11620	COG0318	PFAM AMP-dependent synthetase and ligase
CEP80_RS11625	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CEP80_RS11630	COG0540	Belongs to the ATCase OTCase family
CEP80_RS11635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CEP80_RS11650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CEP80_RS11655	COG0284	orotidine-5'-phosphate decarboxylase activity
CEP80_RS11665	COG0194	GDP metabolic process
CEP80_RS11670	COG1758	RNA polymerase activity
CEP80_RS11680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEP80_RS11690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEP80_RS11700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CEP80_RS11705	COG0140	phosphoribosyl-ATP diphosphatase activity
CEP80_RS11710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEP80_RS11745	COG1716	ATPase activity
CEP80_RS11765	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CEP80_RS11770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEP80_RS11780	COG0463	Glycosyl transferase, family 2
CEP80_RS11785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CEP80_RS11790	COG1228	amidohydrolase
CEP80_RS11800	COG0805	protein transport
CEP80_RS11805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEP80_RS11815	COG2378	regulation of single-species biofilm formation
CEP80_RS11835	COG0714	Associated with various cellular activities
CEP80_RS11845	COG1739	Uncharacterized protein family UPF0029
CEP80_RS11890	COG1160	GTP binding
CEP80_RS11895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEP80_RS11900	COG1187	pseudouridine synthase activity
CEP80_RS11905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CEP80_RS11910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CEP80_RS11925	COG0109	protoheme IX farnesyltransferase activity
CEP80_RS11945	COG0363	glucosamine-6-phosphate deaminase activity
CEP80_RS11950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEP80_RS11955	COG0149	triose-phosphate isomerase activity
CEP80_RS11960	COG0126	phosphoglycerate kinase activity
CEP80_RS11965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEP80_RS11970	COG1481	regulation of sporulation
CEP80_RS11980	COG1660	Displays ATPase and GTPase activities
CEP80_RS11985	COG0322	excinuclease ABC activity
CEP80_RS12010	COG0556	nucleotide-excision repair
CEP80_RS12035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEP80_RS12045	COG0315	cyclic pyranopterin monophosphate synthase activity
CEP80_RS12045	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEP80_RS12050	COG0303	'Molybdopterin
CEP80_RS12065	COG1140	nitrate reductase beta subunit
CEP80_RS12085	COG0237	dephospho-CoA kinase activity
CEP80_RS12090	COG1132	(ABC) transporter
CEP80_RS12100	COG0539	negative regulation of cytoplasmic translation
CEP80_RS12155	COG0067	glutamate synthase
CEP80_RS12155	COG0070	glutamate synthase
CEP80_RS12155	COG0069	glutamate synthase activity
CEP80_RS12160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CEP80_RS12170	COG0133	tryptophan synthase activity
CEP80_RS12175	COG0134	indole-3-glycerol-phosphate synthase activity
CEP80_RS12200	COG1132	(ABC) transporter
CEP80_RS12205	COG1132	(ABC) transporter
CEP80_RS12220	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CEP80_RS12225	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CEP80_RS12230	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CEP80_RS12240	COG4122	O-methyltransferase activity
CEP80_RS12245	COG1222	aaa ATPase
CEP80_RS12265	COG0546	phosphoglycolate phosphatase activity
CEP80_RS12275	COG0215	cysteine-tRNA ligase activity
CEP80_RS12295	COG0339	signal peptide processing
CEP80_RS12325	COG0587	DNA-directed DNA polymerase activity
CEP80_RS12340	COG0352	thiamine-phosphate diphosphorylase activity
CEP80_RS12340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CEP80_RS12340	COG0351	phosphomethylpyrimidine kinase
CEP80_RS12345	COG0352	thiamine-phosphate diphosphorylase activity
CEP80_RS12350	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CEP80_RS12370	COG1119	ATPase activity
CEP80_RS12380	COG2076	Multidrug Resistance protein
CEP80_RS12395	COG0297	glycogen (starch) synthase activity
CEP80_RS12405	COG2837	iron assimilation
CEP80_RS12420	COG3830	Belongs to the UPF0237 family
CEP80_RS12420	COG0560	Phosphoserine phosphatase
CEP80_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
CEP80_RS12460	COG0488	(ABC) transporter
CEP80_RS12465	COG1268	BioY protein
CEP80_RS12470	COG1122	ATPase activity
CEP80_RS12495	COG3467	pyridoxamine 5'-phosphate
CEP80_RS12510	COG1764	response to oxidative stress
CEP80_RS12515	COG1846	Transcriptional regulator
CEP80_RS12535	COG2151	metal-sulfur cluster biosynthetic enzyme
CEP80_RS12540	COG0822	iron-sulfur transferase activity
CEP80_RS12550	COG0396	ATPase activity
CEP80_RS12560	COG0719	Fe-S assembly protein
CEP80_RS12595	COG5297	Belongs to the glycosyl hydrolase family 6
CEP80_RS12595	COG4733	cellulase activity
CEP80_RS12600	COG0494	nUDIX hydrolase
CEP80_RS12605	COG0504	CTP synthase activity
CEP80_RS12615	COG0728	peptidoglycan biosynthetic process
CEP80_RS12635	COG0497	DNA recombination
CEP80_RS12640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEP80_RS12650	COG0647	UMP catabolic process
CEP80_RS12685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEP80_RS12690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEP80_RS12695	COG0165	Argininosuccinate lyase
CEP80_RS12700	COG0137	argininosuccinate synthase activity
CEP80_RS12705	COG1438	arginine binding
CEP80_RS12725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CEP80_RS12730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CEP80_RS12745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEP80_RS12750	COG1113	amino acid transport
CEP80_RS12755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEP80_RS12760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CEP80_RS12765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CEP80_RS12770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CEP80_RS12805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEP80_RS12810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEP80_RS12820	COG0131	Imidazoleglycerol-phosphate dehydratase
CEP80_RS12825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEP80_RS12830	COG0514	ATP-dependent DNA helicase (RecQ)
CEP80_RS12840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEP80_RS12855	COG0587	DNA-directed DNA polymerase activity
CEP80_RS12870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEP80_RS12890	COG1799	cell septum assembly
CEP80_RS12895	COG1496	oxidoreductase activity
CEP80_RS12900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CEP80_RS12910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEP80_RS12915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEP80_RS12925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEP80_RS12930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEP80_RS12935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CEP80_RS12940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEP80_RS12945	COG0768	penicillin binding
CEP80_RS12955	COG0275	rRNA processing
CEP80_RS12960	COG2001	Belongs to the MraZ family
CEP80_RS12970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEP80_RS12990	COG3973	AAA domain
CEP80_RS12995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEP80_RS13000	COG0667	Aldo Keto reductase
CEP80_RS13005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEP80_RS13015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEP80_RS13030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEP80_RS13035	COG2813	Specifically methylates the guanine in position
CEP80_RS13040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEP80_RS13065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEP80_RS13075	COG2137	regulation of response to DNA damage stimulus
CEP80_RS13080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEP80_RS13090	COG1201	RNA secondary structure unwinding
CEP80_RS13095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEP80_RS13100	COG1396	sequence-specific DNA binding
CEP80_RS13105	COG1058	Belongs to the CinA family
CEP80_RS13105	COG1546	Belongs to the CinA family
CEP80_RS13115	COG1674	ftsk spoiiie
CEP80_RS13120	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CEP80_RS13130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CEP80_RS13135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEP80_RS13150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CEP80_RS13155	COG0612	Peptidase, M16