locus-tag	class	description
G3T16_RS00080	COG1648	precorrin-2 dehydrogenase activity
G3T16_RS00080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G3T16_RS00090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G3T16_RS00095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G3T16_RS00100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G3T16_RS00115	COG0492	ferredoxin-NADP+ reductase activity
G3T16_RS00120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G3T16_RS00125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G3T16_RS00130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G3T16_RS00135	COG0542	response to heat
G3T16_RS00140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G3T16_RS00150	COG1187	pseudouridine synthase activity
G3T16_RS00155	COG0494	nUDIX hydrolase
G3T16_RS00160	COG0482	sulfurtransferase activity
G3T16_RS00165	COG2915	High frequency lysogenization protein hflD homolog
G3T16_RS00175	COG2850	peptidyl-arginine hydroxylation
G3T16_RS00190	COG1703	isobutyryl-CoA mutase activity
G3T16_RS00205	COG0439	Biotin carboxylase
G3T16_RS00215	COG0560	Phosphoserine phosphatase
G3T16_RS00235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G3T16_RS00240	COG1862	Preprotein translocase
G3T16_RS00245	COG0708	Exodeoxyribonuclease III
G3T16_RS00250	COG0778	Nitroreductase
G3T16_RS00255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3T16_RS00285	COG1006	Multisubunit Na H antiporter MnhC subunit
G3T16_RS00295	COG0651	ATP synthesis coupled electron transport
G3T16_RS00315	COG0515	serine threonine protein kinase
G3T16_RS00340	COG0577	efflux transmembrane transporter activity
G3T16_RS00340	COG1136	(ABC) transporter
G3T16_RS00345	COG2010	Cytochrome c
G3T16_RS00350	COG3256	nitric oxide reductase
G3T16_RS00355	COG0714	Associated with various cellular activities
G3T16_RS00370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3T16_RS00390	COG0642	Histidine kinase
G3T16_RS00410	COG4993	Dehydrogenase
G3T16_RS00430	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G3T16_RS00435	COG4638	Rieske (2fe-2S)
G3T16_RS00440	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3T16_RS00445	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS00470	COG2146	nitrite reductase [NAD(P)H] activity
G3T16_RS00475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G3T16_RS00480	COG4638	Rieske (2fe-2S)
G3T16_RS00485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3T16_RS00495	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS00535	COG1228	amidohydrolase
G3T16_RS00545	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS00550	COG5001	Diguanylate cyclase
G3T16_RS00585	COG0346	lactoylglutathione lyase activity
G3T16_RS00605	COG0402	S-adenosylhomocysteine deaminase activity
G3T16_RS00630	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS00685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3T16_RS00690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3T16_RS00695	COG0583	DNA-binding transcription factor activity
G3T16_RS00720	COG1760	l-serine dehydratase
G3T16_RS00725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3T16_RS00735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3T16_RS00740	COG1840	ABC-type Fe3 transport system, periplasmic component
G3T16_RS00750	COG3842	ATPase activity
G3T16_RS00760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3T16_RS00765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G3T16_RS00785	COG2853	Lipoprotein
G3T16_RS00795	COG3220	belongs to the UPF0276 family
G3T16_RS00805	COG1643	Atp-dependent helicase
G3T16_RS00815	COG2030	dehydratase
G3T16_RS00860	COG0471	metal ion transport
G3T16_RS00860	COG3273	potassium ion transport
G3T16_RS00870	COG0604	alcohol dehydrogenase
G3T16_RS00880	COG1278	Cold shock
G3T16_RS00895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3T16_RS00900	COG4771	TonB-dependent receptor
G3T16_RS00935	COG0514	ATP-dependent DNA helicase (RecQ)
G3T16_RS00940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G3T16_RS00955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G3T16_RS00965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3T16_RS00975	COG5265	(ABC) transporter
G3T16_RS00980	COG2137	regulation of response to DNA damage stimulus
G3T16_RS00985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G3T16_RS01010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3T16_RS01015	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G3T16_RS01020	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G3T16_RS01035	COG1067	ATP-dependent peptidase activity
G3T16_RS01040	COG0574	Belongs to the PEP-utilizing enzyme family
G3T16_RS01040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G3T16_RS01055	COG3795	YCII-related domain
G3T16_RS01065	COG1858	cytochrome C peroxidase
G3T16_RS01070	COG3391	amine dehydrogenase activity
G3T16_RS01080	COG0300	oxidoreductase activity
G3T16_RS01095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS01100	COG1846	Transcriptional regulator
G3T16_RS01155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3T16_RS01175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3T16_RS01190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G3T16_RS01195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G3T16_RS01200	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G3T16_RS01210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G3T16_RS01215	COG0504	CTP synthase activity
G3T16_RS01230	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
G3T16_RS01240	COG3630	sodium ion export across plasma membrane
G3T16_RS01245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3T16_RS01250	COG4221	oxidoreductase activity
G3T16_RS01265	COG3104	oligopeptide transport
G3T16_RS01275	COG0247	lactate metabolic process
G3T16_RS01285	COG1556	Lactate utilization protein
G3T16_RS01290	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G3T16_RS01300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3T16_RS01315	COG0513	Belongs to the DEAD box helicase family
G3T16_RS01335	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS01340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3T16_RS01360	COG0396	ATPase activity
G3T16_RS01365	COG0719	Fe-S assembly protein
G3T16_RS01375	COG0316	Belongs to the HesB IscA family
G3T16_RS01475	COG0484	heat shock protein binding
G3T16_RS01480	COG0745	RESPONSE REGULATOR receiver
G3T16_RS01485	COG2205	protein histidine kinase activity
G3T16_RS01495	COG0569	domain protein
G3T16_RS01510	COG0642	Histidine kinase
G3T16_RS01515	COG0745	RESPONSE REGULATOR receiver
G3T16_RS01525	COG0483	inositol monophosphate 1-phosphatase activity
G3T16_RS01545	COG0673	inositol 2-dehydrogenase activity
G3T16_RS01560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3T16_RS01565	COG0673	inositol 2-dehydrogenase activity
G3T16_RS01575	COG3718	enzyme involved in inositol metabolism
G3T16_RS01615	COG0733	neurotransmitter:sodium symporter activity
G3T16_RS01620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G3T16_RS01635	COG1191	sigma factor activity
G3T16_RS01645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3T16_RS01660	COG0745	RESPONSE REGULATOR receiver
G3T16_RS01665	COG0840	transmembrane signaling receptor activity
G3T16_RS01670	COG2201	protein-glutamate methylesterase activity
G3T16_RS01675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3T16_RS01685	COG0835	chemotaxis
G3T16_RS01715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3T16_RS01740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G3T16_RS01755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G3T16_RS01765	COG1334	flagellar protein FlaG
G3T16_RS01770	COG1677	Flagellar hook-basal body complex protein FliE
G3T16_RS01775	COG1766	The M ring may be actively involved in energy transduction
G3T16_RS01815	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G3T16_RS01835	COG1987	bacterial-type flagellum assembly
G3T16_RS01845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G3T16_RS01855	COG3951	Flagellar rod assembly protein muramidase FlgJ
G3T16_RS01860	COG1706	bacterial-type flagellum-dependent cell motility
G3T16_RS01875	COG4787	bacterial-type flagellum-dependent cell motility
G3T16_RS01885	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G3T16_RS01890	COG1558	bacterial-type flagellum-dependent cell motility
G3T16_RS01915	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G3T16_RS01950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3T16_RS01960	COG2423	ornithine cyclodeaminase activity
G3T16_RS01975	COG3039	Transposase
G3T16_RS01980	COG1253	flavin adenine dinucleotide binding
G3T16_RS01985	COG1253	flavin adenine dinucleotide binding
G3T16_RS02025	COG0140	phosphoribosyl-ATP diphosphatase activity
G3T16_RS02055	COG0842	Transport permease protein
G3T16_RS02060	COG1131	(ABC) transporter
G3T16_RS02080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3T16_RS02085	COG3101	peptidyl-lysine hydroxylation
G3T16_RS02095	COG3089	Belongs to the UPF0270 family
G3T16_RS02120	COG2890	protein-(glutamine-N5) methyltransferase activity
G3T16_RS02125	COG0302	gtp cyclohydrolase
G3T16_RS02135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3T16_RS02140	COG0326	Molecular chaperone. Has ATPase activity
G3T16_RS02150	COG0045	succinate-CoA ligase (ADP-forming) activity
G3T16_RS02175	COG1053	succinate dehydrogenase
G3T16_RS02180	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G3T16_RS02220	COG0573	inorganic phosphate transmembrane transporter activity
G3T16_RS02225	COG0573	inorganic phosphate transmembrane transporter activity
G3T16_RS02250	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G3T16_RS02250	COG0674	pyruvate-flavodoxin oxidoreductase activity
G3T16_RS02265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G3T16_RS02270	COG3115	cell septum assembly
G3T16_RS02300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G3T16_RS02325	COG0037	tRNA processing
G3T16_RS02335	COG1309	transcriptional regulator
G3T16_RS02345	COG4181	ATPase activity
G3T16_RS02365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G3T16_RS02380	COG1196	nuclear chromosome segregation
G3T16_RS02410	COG0798	PFAM Bile acid sodium symporter
G3T16_RS02425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS02430	COG1643	Atp-dependent helicase
G3T16_RS02435	COG0560	Phosphoserine phosphatase
G3T16_RS02450	COG3584	3D domain protein
G3T16_RS02450	COG1388	LysM domain
G3T16_RS02460	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
G3T16_RS02485	COG4771	TonB-dependent receptor
G3T16_RS02490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3T16_RS02500	COG1304	FMN binding
G3T16_RS02515	COG0028	Belongs to the TPP enzyme family
G3T16_RS02525	COG0534	Mate efflux family protein
G3T16_RS02530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3T16_RS02535	COG1506	peptidase
G3T16_RS02535	COG0823	Involved in the tonB-independent uptake of proteins
G3T16_RS02535	COG4946	Tricorn protease homolog
G3T16_RS02540	COG1160	GTP binding
G3T16_RS02565	COG0604	alcohol dehydrogenase
G3T16_RS02565	COG3321	synthase
G3T16_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS02580	COG0598	Magnesium transport protein CorA
G3T16_RS02605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G3T16_RS02640	COG1842	Phage shock protein A
G3T16_RS02645	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G3T16_RS02685	COG1473	amidohydrolase
G3T16_RS02695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G3T16_RS02720	COG1362	aminopeptidase activity
G3T16_RS02725	COG1968	undecaprenyl-diphosphatase activity
G3T16_RS02735	COG0746	molybdenum cofactor guanylyltransferase activity
G3T16_RS02745	COG0563	adenylate kinase activity
G3T16_RS02750	COG3956	TIGRFAM MazG family protein
G3T16_RS02755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3T16_RS02775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G3T16_RS02780	COG0571	ribonuclease III activity
G3T16_RS02795	COG0481	GTPase activity
G3T16_RS02800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3T16_RS02840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G3T16_RS02850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G3T16_RS02855	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G3T16_RS02860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G3T16_RS02875	COG5001	Diguanylate cyclase
G3T16_RS02875	COG5002	protein histidine kinase activity
G3T16_RS02880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3T16_RS02935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3T16_RS02940	COG0527	aspartate kinase activity
G3T16_RS02945	COG1917	Cupin 2, conserved barrel domain protein
G3T16_RS02960	COG1846	Transcriptional regulator
G3T16_RS02965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3T16_RS02980	COG0271	Belongs to the BolA IbaG family
G3T16_RS03000	COG1024	Enoyl-CoA hydratase
G3T16_RS03005	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS03020	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G3T16_RS03060	COG1794	racemase activity, acting on amino acids and derivatives
G3T16_RS03070	COG2353	YceI-like domain
G3T16_RS03075	COG0840	transmembrane signaling receptor activity
G3T16_RS03080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3T16_RS03085	COG0076	glutamate decarboxylase activity
G3T16_RS03095	COG5505	Protein of unknown function (DUF819)
G3T16_RS03105	COG1228	amidohydrolase
G3T16_RS03115	COG4771	TonB-dependent receptor
G3T16_RS03120	COG4771	TonB-dependent receptor
G3T16_RS03135	COG1228	amidohydrolase
G3T16_RS03145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G3T16_RS03150	COG1846	Transcriptional regulator
G3T16_RS03190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3T16_RS03210	COG1846	Transcriptional regulator
G3T16_RS03230	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G3T16_RS03265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G3T16_RS03285	COG4774	siderophore transport
G3T16_RS03315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3T16_RS03345	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G3T16_RS03375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS03420	COG2968	Membrane
G3T16_RS03425	COG1473	amidohydrolase
G3T16_RS03435	COG1752	Esterase of the alpha-beta hydrolase superfamily
G3T16_RS03435	COG1752	Esterase of the alpha-beta hydrolase superfamily
G3T16_RS03440	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G3T16_RS03450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G3T16_RS03465	COG3949	Membrane
G3T16_RS03475	COG0028	Belongs to the TPP enzyme family
G3T16_RS03490	COG0596	Alpha beta hydrolase
G3T16_RS03495	COG4771	TonB-dependent receptor
G3T16_RS03500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G3T16_RS03510	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS03515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G3T16_RS03520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G3T16_RS03535	COG1522	sequence-specific DNA binding
G3T16_RS03555	COG3977	Valine--pyruvate aminotransferase
G3T16_RS03590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3T16_RS03625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3T16_RS03645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3T16_RS03650	COG1505	serine-type exopeptidase activity
G3T16_RS03655	COG1252	NADH dehydrogenase
G3T16_RS03660	COG1203	CRISPR-associated helicase, Cas3
G3T16_RS03690	COG1518	maintenance of DNA repeat elements
G3T16_RS03695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G3T16_RS03715	COG3706	GGDEF domain
G3T16_RS03715	COG4251	negative regulation of phosphorylation
G3T16_RS03715	COG5001	Diguanylate cyclase
G3T16_RS03715	COG2203	Gaf domain
G3T16_RS03720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G3T16_RS03735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3T16_RS03740	COG0640	Transcriptional regulator
G3T16_RS03760	COG0776	regulation of translation
G3T16_RS03770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G3T16_RS03780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G3T16_RS03785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G3T16_RS03815	COG2304	oxidoreductase activity
G3T16_RS03820	COG0745	RESPONSE REGULATOR receiver
G3T16_RS03825	COG2205	protein histidine kinase activity
G3T16_RS03850	COG2501	S4 domain
G3T16_RS03890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3T16_RS03900	COG1555	photosystem II stabilization
G3T16_RS03900	COG1596	polysaccharide export
G3T16_RS03910	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G3T16_RS03920	COG0776	regulation of translation
G3T16_RS03940	COG0287	Prephenate dehydrogenase
G3T16_RS03965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3T16_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS03990	COG2204	response regulator
G3T16_RS04000	COG2205	protein histidine kinase activity
G3T16_RS04005	COG1668	transmembrane transport
G3T16_RS04010	COG4555	ABC transporter
G3T16_RS04015	COG0596	Alpha beta hydrolase
G3T16_RS04035	COG0004	ammonium transporteR
G3T16_RS04040	COG0071	Belongs to the small heat shock protein (HSP20) family
G3T16_RS04110	COG2133	pyrroloquinoline quinone binding
G3T16_RS04170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G3T16_RS04215	COG1365	unkown
G3T16_RS04235	COG2244	polysaccharide biosynthetic process
G3T16_RS04250	COG0438	transferase activity, transferring glycosyl groups
G3T16_RS04255	COG0438	transferase activity, transferring glycosyl groups
G3T16_RS04260	COG0367	asparagine synthase
G3T16_RS04310	COG1596	polysaccharide export
G3T16_RS04315	COG3409	Peptidoglycan-binding domain 1 protein
G3T16_RS04315	COG3267	Type II secretory pathway component ExeA
G3T16_RS04345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3T16_RS04355	COG2204	response regulator
G3T16_RS04395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G3T16_RS04415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3T16_RS04430	COG3706	GGDEF domain
G3T16_RS04435	COG3608	succinylglutamate desuccinylase aspartoacylase
G3T16_RS04440	COG2807	transmembrane transport
G3T16_RS04445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS04475	COG1294	oxidase, subunit
G3T16_RS04480	COG1271	oxidase subunit
G3T16_RS04485	COG0028	Belongs to the TPP enzyme family
G3T16_RS04555	COG3328	transposase activity
G3T16_RS04580	COG2200	EAL domain
G3T16_RS04590	COG4372	Transposase
G3T16_RS04620	COG4968	Prepilin-type N-terminal cleavage methylation domain
G3T16_RS04660	COG2197	response regulator
G3T16_RS04670	COG2274	protein secretion by the type I secretion system
G3T16_RS04685	COG1063	alcohol dehydrogenase
G3T16_RS04695	COG1612	heme a metabolic process
G3T16_RS04700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G3T16_RS04705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G3T16_RS04710	COG0583	DNA-binding transcription factor activity
G3T16_RS04745	COG4106	trans-aconitate 2-methyltransferase activity
G3T16_RS04750	COG0500	methyltransferase
G3T16_RS04755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3T16_RS04760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3T16_RS04780	COG1702	phosphate starvation-inducible protein PhoH
G3T16_RS04785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G3T16_RS04795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G3T16_RS04810	COG1466	dna polymerase III delta subunit
G3T16_RS04830	COG0427	acetyl-CoA hydrolase
G3T16_RS04835	COG4651	solute:proton antiporter activity
G3T16_RS04835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3T16_RS04945	COG3706	GGDEF domain
G3T16_RS04970	COG0784	Response regulator, receiver
G3T16_RS04975	COG3852	Histidine kinase
G3T16_RS04990	COG4771	TonB-dependent receptor
G3T16_RS04995	COG0137	argininosuccinate synthase activity
G3T16_RS05000	COG0418	dihydroorotase activity
G3T16_RS05015	COG5001	Diguanylate cyclase
G3T16_RS05015	COG3300	MHYT domain
G3T16_RS05020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G3T16_RS05035	COG3217	Mosc domain protein beta barrel domain protein
G3T16_RS05035	COG0633	Ferredoxin
G3T16_RS05045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3T16_RS05060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G3T16_RS05065	COG0076	glutamate decarboxylase activity
G3T16_RS05070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3T16_RS05110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3T16_RS05115	COG0205	6-phosphofructokinase activity
G3T16_RS05125	COG1876	peptidase activity
G3T16_RS05130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G3T16_RS05135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3T16_RS05145	COG3852	Histidine kinase
G3T16_RS05165	COG1428	Deoxynucleoside kinase
G3T16_RS05170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G3T16_RS05175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G3T16_RS05180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3T16_RS05185	COG0583	DNA-binding transcription factor activity
G3T16_RS05190	COG0028	Belongs to the TPP enzyme family
G3T16_RS05195	COG1185	polyribonucleotide nucleotidyltransferase activity
G3T16_RS05200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G3T16_RS05210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G3T16_RS05215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G3T16_RS05220	COG0195	Participates in both transcription termination and antitermination
G3T16_RS05255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3T16_RS05275	COG2207	Transcriptional regulator
G3T16_RS05280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3T16_RS05295	COG0805	protein transport
G3T16_RS05300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3T16_RS05305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G3T16_RS05325	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G3T16_RS05330	COG4638	Rieske (2fe-2S)
G3T16_RS05340	COG4774	siderophore transport
G3T16_RS05350	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G3T16_RS05355	COG2267	carboxylic ester hydrolase activity
G3T16_RS05360	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS05375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3T16_RS05380	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G3T16_RS05395	COG0346	lactoylglutathione lyase activity
G3T16_RS05400	COG1942	4-Oxalocrotonate Tautomerase
G3T16_RS05415	COG4771	TonB-dependent receptor
G3T16_RS05455	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G3T16_RS05475	COG0402	S-adenosylhomocysteine deaminase activity
G3T16_RS05480	COG4771	TonB-dependent receptor
G3T16_RS05490	COG1546	Belongs to the CinA family
G3T16_RS05495	COG3033	Beta-eliminating lyase
G3T16_RS05510	COG1846	Transcriptional regulator
G3T16_RS05520	COG4771	TonB-dependent receptor
G3T16_RS05545	COG1802	Transcriptional regulator
G3T16_RS05560	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G3T16_RS05580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3T16_RS05600	COG1295	ribonuclease BN
G3T16_RS05630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G3T16_RS05650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3T16_RS05655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G3T16_RS05660	COG2909	trisaccharide binding
G3T16_RS05670	COG0431	NADPH-dependent FMN reductase
G3T16_RS05675	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS05685	COG4773	Receptor
G3T16_RS05690	COG0492	ferredoxin-NADP+ reductase activity
G3T16_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS05725	COG1454	alcohol dehydrogenase
G3T16_RS05740	COG0583	DNA-binding transcription factor activity
G3T16_RS05770	COG4774	siderophore transport
G3T16_RS05785	COG2814	Major facilitator Superfamily
G3T16_RS05840	COG4771	TonB-dependent receptor
G3T16_RS05845	COG4771	TonB-dependent receptor
G3T16_RS05885	COG1024	Enoyl-CoA hydratase
G3T16_RS05890	COG1024	Enoyl-CoA hydratase
G3T16_RS05895	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS05900	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS05970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G3T16_RS05975	COG0149	triose-phosphate isomerase activity
G3T16_RS05980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3T16_RS05985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G3T16_RS05990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3T16_RS06030	COG2814	Major facilitator Superfamily
G3T16_RS06045	COG0183	Belongs to the thiolase family
G3T16_RS06060	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS06065	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS06070	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS06085	COG0651	ATP synthesis coupled electron transport
G3T16_RS06090	COG0651	ATP synthesis coupled electron transport
G3T16_RS06095	COG0651	ATP synthesis coupled electron transport
G3T16_RS06100	COG1006	Multisubunit Na H antiporter MnhC subunit
G3T16_RS06140	COG2766	serine protein kinase
G3T16_RS06145	COG2718	Belongs to the UPF0229 family
G3T16_RS06150	COG2719	SpoVR family
G3T16_RS06165	COG4977	sequence-specific DNA binding
G3T16_RS06170	COG0730	response to heat
G3T16_RS06180	COG0405	Gamma-glutamyltransferase
G3T16_RS06190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3T16_RS06200	COG0583	DNA-binding transcription factor activity
G3T16_RS06220	COG2030	dehydratase
G3T16_RS06265	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS06270	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS06275	COG1024	Enoyl-CoA hydratase
G3T16_RS06295	COG2072	flavoprotein involved in K transport
G3T16_RS06310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3T16_RS06315	COG1234	tRNA 3'-trailer cleavage
G3T16_RS06330	COG0251	oxidation-reduction process
G3T16_RS06345	COG4372	Transposase
G3T16_RS06355	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS06365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3T16_RS06370	COG1070	Carbohydrate kinase
G3T16_RS06375	COG0159	tryptophan synthase activity
G3T16_RS06395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G3T16_RS06400	COG4948	Mandelate Racemase Muconate Lactonizing
G3T16_RS06410	COG5505	Protein of unknown function (DUF819)
G3T16_RS06420	COG3328	transposase activity
G3T16_RS06425	COG5507	3-demethylubiquinone-9 3-methyltransferase
G3T16_RS06430	COG3795	YCII-related domain
G3T16_RS06445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3T16_RS06450	COG0425	Belongs to the sulfur carrier protein TusA family
G3T16_RS06450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G3T16_RS06455	COG4772	TonB-dependent receptor
G3T16_RS06465	COG3655	Transcriptional regulator
G3T16_RS06490	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
G3T16_RS06495	COG1024	Enoyl-CoA hydratase
G3T16_RS06495	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3T16_RS06510	COG2814	Major facilitator Superfamily
G3T16_RS06550	COG2814	Major facilitator Superfamily
G3T16_RS06560	COG0028	Belongs to the TPP enzyme family
G3T16_RS06580	COG3568	Endonuclease Exonuclease Phosphatase
G3T16_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS06615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3T16_RS06630	COG0583	DNA-binding transcription factor activity
G3T16_RS06655	COG4773	Receptor
G3T16_RS06670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3T16_RS06675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS06680	COG1309	transcriptional regulator
G3T16_RS06690	COG0500	methyltransferase
G3T16_RS06705	COG5002	protein histidine kinase activity
G3T16_RS06725	COG3177	Filamentation induced by cAMP protein fic
G3T16_RS06740	COG2304	oxidoreductase activity
G3T16_RS06755	COG3385	transposase activity
G3T16_RS06770	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G3T16_RS06800	COG3385	transposase activity
G3T16_RS06870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G3T16_RS06875	COG0602	queuosine metabolic process
G3T16_RS06880	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
G3T16_RS06890	COG0823	Involved in the tonB-independent uptake of proteins
G3T16_RS06910	COG0824	Thioesterase
G3T16_RS06915	COG2255	four-way junction helicase activity
G3T16_RS06920	COG0632	four-way junction helicase activity
G3T16_RS06925	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G3T16_RS06935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G3T16_RS06950	COG0442	prolyl-tRNA aminoacylation
G3T16_RS06955	COG0741	lytic transglycosylase activity
G3T16_RS06965	COG0174	glutamine synthetase
G3T16_RS06970	COG3021	interspecies interaction between organisms
G3T16_RS06980	COG0386	Belongs to the glutathione peroxidase family
G3T16_RS06985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G3T16_RS06990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS06995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3T16_RS07005	COG4773	Receptor
G3T16_RS07010	COG4771	TonB-dependent receptor
G3T16_RS07015	COG0402	S-adenosylhomocysteine deaminase activity
G3T16_RS07020	COG3844	kynureninase activity
G3T16_RS07030	COG1522	sequence-specific DNA binding
G3T16_RS07035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3T16_RS07040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS07050	COG0033	Phosphoglucomutase
G3T16_RS07055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G3T16_RS07070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3T16_RS07075	COG1640	4-alpha-glucanotransferase
G3T16_RS07080	COG0321	lipoyl(octanoyl) transferase activity
G3T16_RS07085	COG2921	Belongs to the UPF0250 family
G3T16_RS07090	COG1686	Belongs to the peptidase S11 family
G3T16_RS07100	COG2951	lytic endotransglycosylase activity
G3T16_RS07115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G3T16_RS07125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G3T16_RS07130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G3T16_RS07145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G3T16_RS07150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G3T16_RS07155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G3T16_RS07160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3T16_RS07160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G3T16_RS07165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3T16_RS07185	COG0490	domain, Protein
G3T16_RS07185	COG0471	metal ion transport
G3T16_RS07190	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3T16_RS07190	COG1024	Enoyl-CoA hydratase
G3T16_RS07195	COG0183	Belongs to the thiolase family
G3T16_RS07210	COG1199	ATP-dependent helicase activity
G3T16_RS07220	COG2365	Tyrosine phosphatase family
G3T16_RS07225	COG0268	Binds directly to 16S ribosomal RNA
G3T16_RS07235	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G3T16_RS07275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G3T16_RS07280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3T16_RS07325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G3T16_RS07340	COG2918	glutathione biosynthetic process
G3T16_RS07345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G3T16_RS07355	COG0545	Peptidyl-prolyl cis-trans isomerase
G3T16_RS07370	COG2827	Endonuclease containing a URI domain
G3T16_RS07385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G3T16_RS07390	COG3071	HemY protein
G3T16_RS07395	COG2959	enzyme of heme biosynthesis
G3T16_RS07400	COG1587	Uroporphyrinogen-III synthase
G3T16_RS07415	COG2972	Histidine kinase
G3T16_RS07415	COG0745	RESPONSE REGULATOR receiver
G3T16_RS07420	COG0165	Argininosuccinate lyase
G3T16_RS07435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G3T16_RS07450	COG1011	Hydrolase
G3T16_RS07465	COG5001	Diguanylate cyclase
G3T16_RS07465	COG3447	MASE1 domain protein
G3T16_RS07465	COG5002	protein histidine kinase activity
G3T16_RS07480	COG0004	ammonium transporteR
G3T16_RS07540	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G3T16_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS07565	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
G3T16_RS07575	COG2814	Major facilitator Superfamily
G3T16_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS07615	COG1021	2,3-dihydroxybenzoate-AMP ligase
G3T16_RS07650	COG0625	glutathione transferase activity
G3T16_RS07675	COG4773	Receptor
G3T16_RS07680	COG1309	transcriptional regulator
G3T16_RS07715	COG1403	HNH endonuclease
G3T16_RS07735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3T16_RS07740	COG0583	DNA-binding transcription factor activity
G3T16_RS07775	COG0745	RESPONSE REGULATOR receiver
G3T16_RS07805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3T16_RS07810	COG2329	Antibiotic biosynthesis monooxygenase
G3T16_RS07820	COG0366	Alpha amylase catalytic
G3T16_RS07825	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G3T16_RS07835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G3T16_RS07840	COG3383	formate dehydrogenase (NAD+) activity
G3T16_RS07860	COG0583	DNA-binding transcription factor activity
G3T16_RS07865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3T16_RS07870	COG3706	GGDEF domain
G3T16_RS07890	COG2323	membrane
G3T16_RS07900	COG0783	Belongs to the Dps family
G3T16_RS07905	COG1283	sodium-dependent phosphate transmembrane transporter activity
G3T16_RS07915	COG2205	protein histidine kinase activity
G3T16_RS07915	COG0745	RESPONSE REGULATOR receiver
G3T16_RS07915	COG3292	Two component regulator propeller
G3T16_RS07925	COG0154	amidase activity
G3T16_RS07930	COG1611	Belongs to the LOG family
G3T16_RS07945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3T16_RS07950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G3T16_RS07975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3T16_RS07980	COG0352	thiamine-phosphate diphosphorylase activity
G3T16_RS07985	COG2022	thiamine diphosphate biosynthetic process
G3T16_RS08000	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G3T16_RS08005	COG0167	dihydroorotate dehydrogenase activity
G3T16_RS08015	COG2894	cell division
G3T16_RS08020	COG0850	regulation of cytokinetic process
G3T16_RS08025	COG0427	acetyl-CoA hydrolase
G3T16_RS08060	COG2815	serine threonine protein kinase
G3T16_RS08060	COG0515	serine threonine protein kinase
G3T16_RS08070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3T16_RS08075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3T16_RS08085	COG1845	cytochrome c oxidase, subunit III
G3T16_RS08110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3T16_RS08140	COG2204	response regulator
G3T16_RS08155	COG3850	Histidine kinase
G3T16_RS08155	COG5002	protein histidine kinase activity
G3T16_RS08185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3T16_RS08190	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS08195	COG0583	DNA-binding transcription factor activity
G3T16_RS08225	COG4771	TonB-dependent receptor
G3T16_RS08280	COG1595	DNA-templated transcription, initiation
G3T16_RS08290	COG0174	glutamine synthetase
G3T16_RS08300	COG1519	Transferase
G3T16_RS08305	COG1560	Kdo2-lipid A biosynthetic process
G3T16_RS08320	COG0438	transferase activity, transferring glycosyl groups
G3T16_RS08335	COG3642	lipopolysaccharide core region biosynthetic process
G3T16_RS08340	COG0859	PFAM glycosyl transferase family 9
G3T16_RS08350	COG0730	response to heat
G3T16_RS08355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G3T16_RS08370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G3T16_RS08390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3T16_RS08395	COG0363	glucosamine-6-phosphate deaminase activity
G3T16_RS08425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G3T16_RS08440	COG4771	TonB-dependent receptor
G3T16_RS08445	COG0028	Belongs to the TPP enzyme family
G3T16_RS08450	COG0028	Belongs to the TPP enzyme family
G3T16_RS08470	COG2197	response regulator
G3T16_RS08495	COG2084	Dehydrogenase
G3T16_RS08530	COG1309	transcriptional regulator
G3T16_RS08540	COG0154	amidase activity
G3T16_RS08545	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS08555	COG3457	Alanine racemase
G3T16_RS08560	COG0436	Aminotransferase
G3T16_RS08570	COG1024	Enoyl-CoA hydratase
G3T16_RS08585	COG3706	GGDEF domain
G3T16_RS08590	COG4251	negative regulation of phosphorylation
G3T16_RS08620	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS08680	COG0469	pyruvate kinase activity
G3T16_RS08690	COG1278	Cold shock
G3T16_RS08705	COG0848	biopolymer transport protein
G3T16_RS08710	COG0811	peptide transport
G3T16_RS08715	COG0811	peptide transport
G3T16_RS08730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G3T16_RS08735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G3T16_RS08745	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
G3T16_RS08750	COG0494	nUDIX hydrolase
G3T16_RS08760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G3T16_RS08765	COG0509	glycine decarboxylation via glycine cleavage system
G3T16_RS08770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3T16_RS08775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3T16_RS08780	COG0006	proline dipeptidase activity
G3T16_RS08785	COG3079	Belongs to the UPF0149 family
G3T16_RS08815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3T16_RS08820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G3T16_RS08830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3T16_RS08875	COG2095	MarC family integral membrane protein
G3T16_RS08910	COG0126	phosphoglycerate kinase activity
G3T16_RS08915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3T16_RS08920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G3T16_RS08930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G3T16_RS08950	COG4206	TonB-dependent receptor
G3T16_RS08960	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS08965	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS08975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3T16_RS08980	COG0183	Belongs to the thiolase family
G3T16_RS08990	COG2909	trisaccharide binding
G3T16_RS09000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G3T16_RS09005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G3T16_RS09015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G3T16_RS09020	COG0189	ligase activity
G3T16_RS09030	COG1678	Uncharacterized ACR, COG1678
G3T16_RS09065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3T16_RS09070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3T16_RS09070	COG2813	Specifically methylates the guanine in position
G3T16_RS09080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G3T16_RS09085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3T16_RS09090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G3T16_RS09095	COG2363	Small membrane protein
G3T16_RS09105	COG2177	Part of the ABC transporter FtsEX involved in
G3T16_RS09110	COG2884	Cell division ATP-binding protein ftsE
G3T16_RS09125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G3T16_RS09135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G3T16_RS09140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G3T16_RS09145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G3T16_RS09155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G3T16_RS09165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3T16_RS09170	COG1309	transcriptional regulator
G3T16_RS09180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G3T16_RS09190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G3T16_RS09195	COG1561	YicC-like family, N-terminal region
G3T16_RS09200	COG0667	Aldo Keto reductase
G3T16_RS09225	COG1917	Cupin 2, conserved barrel domain protein
G3T16_RS09225	COG4977	sequence-specific DNA binding
G3T16_RS09240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3T16_RS09255	COG0194	GDP metabolic process
G3T16_RS09260	COG0540	Belongs to the ATCase OTCase family
G3T16_RS09265	COG1758	RNA polymerase activity
G3T16_RS09270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3T16_RS09290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G3T16_RS09300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3T16_RS09305	COG3161	chorismate lyase activity
G3T16_RS09310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G3T16_RS09320	COG3022	response to hydroperoxide
G3T16_RS09330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3T16_RS09335	COG1607	acyl-coa hydrolase
G3T16_RS09340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3T16_RS09350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G3T16_RS09355	COG0210	DNA helicase
G3T16_RS09370	COG0583	DNA-binding transcription factor activity
G3T16_RS09375	COG1704	LemA family
G3T16_RS09380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G3T16_RS09395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3T16_RS09400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3T16_RS09405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3T16_RS09410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G3T16_RS09415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G3T16_RS09420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G3T16_RS09425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3T16_RS09440	COG0356	it plays a direct role in the translocation of protons across the membrane
G3T16_RS09450	COG1475	DNA binding
G3T16_RS09455	COG1192	Involved in chromosome partitioning
G3T16_RS09465	COG0445	tRNA wobble uridine modification
G3T16_RS09485	COG0732	type I restriction modification DNA specificity domain
G3T16_RS09510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G3T16_RS09520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G3T16_RS09525	COG0594	ribonuclease P activity
G3T16_RS09530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G3T16_RS09535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3T16_RS09545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G3T16_RS09555	COG2217	Heavy metal translocating P-type atpase
G3T16_RS09560	COG0789	Transcriptional regulator
G3T16_RS09595	COG4771	TonB-dependent receptor
G3T16_RS09605	COG0022	dehydrogenase e1 component
G3T16_RS09610	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3T16_RS09625	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3T16_RS09655	COG4372	Transposase
G3T16_RS09730	COG0784	Response regulator, receiver
G3T16_RS09730	COG2198	Histidine kinase
G3T16_RS09730	COG0643	Histidine kinase
G3T16_RS09755	COG3706	GGDEF domain
G3T16_RS09765	COG0751	glycine-tRNA ligase activity
G3T16_RS09770	COG0752	glycyl-tRNA synthetase alpha subunit
G3T16_RS09775	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G3T16_RS09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G3T16_RS09785	COG0569	domain protein
G3T16_RS09795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3T16_RS09810	COG0758	DNA mediated transformation
G3T16_RS09815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G3T16_RS09820	COG0009	L-threonylcarbamoyladenylate synthase
G3T16_RS09835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G3T16_RS09845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3T16_RS09850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3T16_RS09855	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G3T16_RS09895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G3T16_RS09910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3T16_RS09915	COG2204	response regulator
G3T16_RS09925	COG3852	Histidine kinase
G3T16_RS09940	COG1522	sequence-specific DNA binding
G3T16_RS09945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3T16_RS09950	COG1115	amino acid carrier protein
G3T16_RS09970	COG3122	Protein conserved in bacteria
G3T16_RS09975	COG2814	Major facilitator Superfamily
G3T16_RS09990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3T16_RS09990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G3T16_RS09995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3T16_RS10000	COG0306	phosphate transporter
G3T16_RS10005	COG1392	Phosphate transport regulator
G3T16_RS10015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G3T16_RS10025	COG2267	carboxylic ester hydrolase activity
G3T16_RS10035	COG1088	dTDP-glucose 4,6-dehydratase activity
G3T16_RS10185	COG3328	transposase activity
G3T16_RS10195	COG3385	transposase activity
G3T16_RS10215	COG0589	response to stress
G3T16_RS10235	COG0438	transferase activity, transferring glycosyl groups
G3T16_RS10240	COG2226	methyltransferase
G3T16_RS10255	COG1538	Outer membrane efflux protein
G3T16_RS10265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G3T16_RS10285	COG0784	Response regulator, receiver
G3T16_RS10295	COG0243	molybdopterin cofactor binding
G3T16_RS10305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3T16_RS10305	COG2146	nitrite reductase [NAD(P)H] activity
G3T16_RS10310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3T16_RS10315	COG1116	anion transmembrane transporter activity
G3T16_RS10325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3T16_RS10325	COG1116	anion transmembrane transporter activity
G3T16_RS10340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3T16_RS10340	COG1116	anion transmembrane transporter activity
G3T16_RS10345	COG3707	response regulator
G3T16_RS10385	COG2974	May be involved in recombination
G3T16_RS10390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G3T16_RS10400	COG0709	Synthesizes selenophosphate from selenide and ATP
G3T16_RS10405	COG3279	Response regulator of the LytR AlgR family
G3T16_RS10410	COG3275	phosphorelay sensor kinase activity
G3T16_RS10420	COG2119	membrane
G3T16_RS10430	COG3038	cytochrome b561
G3T16_RS10435	COG2353	YceI-like domain
G3T16_RS10485	COG0251	oxidation-reduction process
G3T16_RS10495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3T16_RS10510	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G3T16_RS10515	COG1194	a g-specific adenine glycosylase
G3T16_RS10530	COG0131	Imidazoleglycerol-phosphate dehydratase
G3T16_RS10540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G3T16_RS10545	COG0107	imidazoleglycerol-phosphate synthase activity
G3T16_RS10555	COG0793	Belongs to the peptidase S41A family
G3T16_RS10560	COG4942	peptidase
G3T16_RS10585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3T16_RS10605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G3T16_RS10610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G3T16_RS10615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G3T16_RS10625	COG3852	Histidine kinase
G3T16_RS10635	COG0174	glutamine synthetase
G3T16_RS10645	COG1490	D-aminoacyl-tRNA deacylase activity
G3T16_RS10650	COG2153	protein acetylation
G3T16_RS10655	COG1047	Peptidyl-prolyl cis-trans
G3T16_RS10675	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G3T16_RS10680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G3T16_RS10690	COG0560	Phosphoserine phosphatase
G3T16_RS10690	COG3830	Belongs to the UPF0237 family
G3T16_RS10700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3T16_RS10705	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G3T16_RS10730	COG1199	ATP-dependent helicase activity
G3T16_RS10735	COG3604	Transcriptional regulator
G3T16_RS10740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G3T16_RS10740	COG1017	nitric oxide dioxygenase activity
G3T16_RS10760	COG1132	(ABC) transporter
G3T16_RS10770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3T16_RS10775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3T16_RS10780	COG0140	phosphoribosyl-ATP diphosphatase activity
G3T16_RS10785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G3T16_RS10800	COG2226	methyltransferase
G3T16_RS10810	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G3T16_RS10815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G3T16_RS10825	COG0018	arginyl-trna synthetase
G3T16_RS10830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G3T16_RS10875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G3T16_RS10880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G3T16_RS10885	COG0070	glutamate synthase
G3T16_RS10885	COG0069	glutamate synthase activity
G3T16_RS10885	COG0067	glutamate synthase
G3T16_RS10890	COG0493	'glutamate synthase
G3T16_RS10895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G3T16_RS10900	COG1045	serine acetyltransferase
G3T16_RS10910	COG0110	maltose O-acetyltransferase activity
G3T16_RS10915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G3T16_RS10920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G3T16_RS10935	COG1040	competence protein
G3T16_RS10940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G3T16_RS10950	COG1073	alpha beta
G3T16_RS10950	COG2226	methyltransferase
G3T16_RS10960	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS10990	COG0488	(ABC) transporter
G3T16_RS11000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G3T16_RS11005	COG0432	Pfam Uncharacterised protein family UPF0047
G3T16_RS11010	COG3177	Filamentation induced by cAMP protein fic
G3T16_RS11025	COG0432	Pfam Uncharacterised protein family UPF0047
G3T16_RS11040	COG3971	2-oxopent-4-enoate hydratase activity
G3T16_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS11070	COG1846	Transcriptional regulator
G3T16_RS11095	COG0515	serine threonine protein kinase
G3T16_RS11095	COG2815	serine threonine protein kinase
G3T16_RS11110	COG1509	lysine 2,3-aminomutase activity
G3T16_RS11125	COG0625	glutathione transferase activity
G3T16_RS11130	COG1802	Transcriptional regulator
G3T16_RS11135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3T16_RS11140	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS11185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3T16_RS11200	COG2072	flavoprotein involved in K transport
G3T16_RS11235	COG4771	TonB-dependent receptor
G3T16_RS11240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G3T16_RS11245	COG0667	Aldo Keto reductase
G3T16_RS11255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3T16_RS11270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3T16_RS11275	COG0174	glutamine synthetase
G3T16_RS11285	COG0583	DNA-binding transcription factor activity
G3T16_RS11295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G3T16_RS11300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3T16_RS11310	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3T16_RS11315	COG0589	response to stress
G3T16_RS11330	COG3706	GGDEF domain
G3T16_RS11340	COG4681	YaeQ
G3T16_RS11350	COG0515	serine threonine protein kinase
G3T16_RS11350	COG2815	serine threonine protein kinase
G3T16_RS11365	COG2133	pyrroloquinoline quinone binding
G3T16_RS11380	COG2951	lytic endotransglycosylase activity
G3T16_RS11385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G3T16_RS11395	COG3360	Dodecin
G3T16_RS11410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G3T16_RS11415	COG1404	Belongs to the peptidase S8 family
G3T16_RS11430	COG0217	transcriptional regulatory protein
G3T16_RS11435	COG0625	glutathione transferase activity
G3T16_RS11440	COG0402	S-adenosylhomocysteine deaminase activity
G3T16_RS11450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3T16_RS11460	COG4773	Receptor
G3T16_RS11465	COG0385	Bile acid
G3T16_RS11480	COG0277	FAD linked oxidase domain protein
G3T16_RS11525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3T16_RS11550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G3T16_RS11560	COG0617	tRNA 3'-terminal CCA addition
G3T16_RS11565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G3T16_RS11575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3T16_RS11595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3T16_RS11610	COG2244	polysaccharide biosynthetic process
G3T16_RS11635	COG0438	transferase activity, transferring glycosyl groups
G3T16_RS11645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G3T16_RS11675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3T16_RS11685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3T16_RS11690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G3T16_RS11695	COG3178	'Phosphotransferase
G3T16_RS11700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3T16_RS11705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G3T16_RS11715	COG0659	secondary active sulfate transmembrane transporter activity
G3T16_RS11730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3T16_RS11735	COG0134	indole-3-glycerol-phosphate synthase activity
G3T16_RS11745	COG1765	OsmC-like protein
G3T16_RS11755	COG0151	Belongs to the GarS family
G3T16_RS11790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3T16_RS11815	COG0417	DNA replication proofreading
G3T16_RS11820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3T16_RS11825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3T16_RS11835	COG1119	ATPase activity
G3T16_RS11855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3T16_RS11865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G3T16_RS11875	COG0316	Belongs to the HesB IscA family
G3T16_RS11880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G3T16_RS11885	COG0739	heme binding
G3T16_RS11945	COG2183	response to ionizing radiation
G3T16_RS11955	COG3706	GGDEF domain
G3T16_RS11960	COG0435	Glutathione S-transferase
G3T16_RS11965	COG3385	transposase activity
G3T16_RS11970	COG1741	Belongs to the pirin family
G3T16_RS11980	COG1301	dicarboxylic acid transport
G3T16_RS11985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3T16_RS11990	COG0501	Belongs to the peptidase M48B family
G3T16_RS12065	COG0405	Gamma-glutamyltransferase
G3T16_RS12075	COG0259	pyridoxamine-phosphate oxidase activity
G3T16_RS12090	COG0545	Peptidyl-prolyl cis-trans isomerase
G3T16_RS12140	COG1162	GTPase activity
G3T16_RS12145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G3T16_RS12165	COG0726	polysaccharide deacetylase
G3T16_RS12165	COG1649	PFAM Uncharacterised BCR, COG1649
G3T16_RS12170	COG0515	serine threonine protein kinase
G3T16_RS12170	COG2815	serine threonine protein kinase
G3T16_RS12185	COG1309	transcriptional regulator
G3T16_RS12190	COG0145	ligase activity
G3T16_RS12200	COG4647	ligase activity
G3T16_RS12210	COG0145	ligase activity
G3T16_RS12215	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
G3T16_RS12230	COG0183	Belongs to the thiolase family
G3T16_RS12240	COG4771	TonB-dependent receptor
G3T16_RS12245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3T16_RS12250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G3T16_RS12255	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G3T16_RS12285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G3T16_RS12285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G3T16_RS12290	COG0802	atpase or kinase
G3T16_RS12295	COG0860	N-Acetylmuramoyl-L-alanine amidase
G3T16_RS12300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G3T16_RS12305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G3T16_RS12310	COG1923	regulation of RNA biosynthetic process
G3T16_RS12315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G3T16_RS12320	COG0330	HflC and HflK could
G3T16_RS12325	COG0330	HflC and HflK could
G3T16_RS12330	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
G3T16_RS12335	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G3T16_RS12345	COG3788	relative of glutathione S-transferase, MAPEG superfamily
G3T16_RS12355	COG0501	Belongs to the peptidase M48B family
G3T16_RS12360	COG1704	LemA family
G3T16_RS12365	COG0534	Mate efflux family protein
G3T16_RS12370	COG0243	molybdopterin cofactor binding
G3T16_RS12395	COG3153	acetyltransferase
G3T16_RS12410	COG0456	acetyltransferase
G3T16_RS12425	COG0604	alcohol dehydrogenase
G3T16_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS12425	COG3321	synthase
G3T16_RS12430	COG4221	oxidoreductase activity
G3T16_RS12470	COG0530	calcium, potassium:sodium antiporter activity
G3T16_RS12475	COG1228	amidohydrolase
G3T16_RS12480	COG4771	TonB-dependent receptor
G3T16_RS12485	COG1429	ligase activity, forming nitrogen-metal bonds
G3T16_RS12490	COG1429	ligase activity, forming nitrogen-metal bonds
G3T16_RS12505	COG0745	RESPONSE REGULATOR receiver
G3T16_RS12535	COG3385	transposase activity
G3T16_RS12540	COG4771	TonB-dependent receptor
G3T16_RS12545	COG2909	trisaccharide binding
G3T16_RS12560	COG3550	peptidyl-serine autophosphorylation
G3T16_RS12590	COG0360	Binds together with S18 to 16S ribosomal RNA
G3T16_RS12595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G3T16_RS12610	COG0305	Participates in initiation and elongation during chromosome replication
G3T16_RS12635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G3T16_RS12640	COG0492	ferredoxin-NADP+ reductase activity
G3T16_RS12675	COG0631	protein serine/threonine phosphatase activity
G3T16_RS12690	COG0488	(ABC) transporter
G3T16_RS12700	COG4067	protein conserved in archaea
G3T16_RS12700	COG0189	ligase activity
G3T16_RS12710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G3T16_RS12725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3T16_RS12725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3T16_RS12740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G3T16_RS12745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3T16_RS12755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G3T16_RS12765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3T16_RS12775	COG0142	geranyltranstransferase activity
G3T16_RS12780	COG1722	exodeoxyribonuclease VII activity
G3T16_RS12825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G3T16_RS12845	COG3706	GGDEF domain
G3T16_RS12845	COG4251	negative regulation of phosphorylation
G3T16_RS12845	COG5001	Diguanylate cyclase
G3T16_RS12845	COG2203	Gaf domain
G3T16_RS12850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G3T16_RS12855	COG1011	Hydrolase
G3T16_RS12870	COG5285	phytanoyl-CoA dioxygenase
G3T16_RS12895	COG4770	biotin carboxylase activity
G3T16_RS12900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G3T16_RS12905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3T16_RS12915	COG0789	Transcriptional regulator
G3T16_RS12925	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G3T16_RS12945	COG4948	Mandelate Racemase Muconate Lactonizing
G3T16_RS12950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G3T16_RS12965	COG2032	superoxide dismutase activity
G3T16_RS12980	COG1131	(ABC) transporter
G3T16_RS12990	COG1573	uracil-dna glycosylase
G3T16_RS12995	COG4941	Belongs to the sigma-70 factor family
G3T16_RS13000	COG3795	YCII-related domain
G3T16_RS13040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3T16_RS13060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G3T16_RS13065	COG0081	regulation of translation
G3T16_RS13070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G3T16_RS13075	COG0222	ribosome binding
G3T16_RS13080	COG0085	RNA polymerase activity
G3T16_RS13085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G3T16_RS13090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G3T16_RS13095	COG0049	tRNA binding
G3T16_RS13100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G3T16_RS13120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G3T16_RS13125	COG0051	transcription antitermination factor activity, RNA binding
G3T16_RS13130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G3T16_RS13135	COG0088	Forms part of the polypeptide exit tunnel
G3T16_RS13140	COG0089	rRNA binding
G3T16_RS13145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G3T16_RS13150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G3T16_RS13155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G3T16_RS13160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G3T16_RS13165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G3T16_RS13170	COG0255	Belongs to the universal ribosomal protein uL29 family
G3T16_RS13175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G3T16_RS13180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G3T16_RS13185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G3T16_RS13190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G3T16_RS13200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G3T16_RS13205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G3T16_RS13210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G3T16_RS13215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G3T16_RS13220	COG1841	ribosomal large subunit assembly
G3T16_RS13225	COG0200	Binds to the 23S rRNA
G3T16_RS13240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G3T16_RS13245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G3T16_RS13250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G3T16_RS13255	COG0202	RNA polymerase activity
G3T16_RS13260	COG0203	ribosomal protein L17
G3T16_RS13285	COG0521	Mo-molybdopterin cofactor biosynthetic process
G3T16_RS13300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3T16_RS13325	COG0142	geranyltranstransferase activity
G3T16_RS13355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G3T16_RS13360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G3T16_RS13375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G3T16_RS13385	COG1473	amidohydrolase
G3T16_RS13405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G3T16_RS13420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G3T16_RS13445	COG2205	protein histidine kinase activity
G3T16_RS13445	COG5002	protein histidine kinase activity
G3T16_RS13445	COG0784	Response regulator, receiver
G3T16_RS13455	COG0745	RESPONSE REGULATOR receiver
G3T16_RS13485	COG2391	methyltransferase activity
G3T16_RS13515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G3T16_RS13520	COG0733	neurotransmitter:sodium symporter activity
G3T16_RS13525	COG2867	negative regulation of translational initiation
G3T16_RS13530	COG2914	Belongs to the UPF0125 (RnfH) family
G3T16_RS13545	COG0497	DNA recombination
G3T16_RS13555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G3T16_RS13560	COG0443	Heat shock 70 kDa protein
G3T16_RS13565	COG0484	heat shock protein binding
G3T16_RS13570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G3T16_RS13575	COG3118	belongs to the thioredoxin family
G3T16_RS13585	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS13590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3T16_RS13595	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS13605	COG1946	Acyl-CoA thioesterase
G3T16_RS13615	COG0519	Catalyzes the synthesis of GMP from XMP
G3T16_RS13625	COG1024	Enoyl-CoA hydratase
G3T16_RS13630	COG3920	Histidine kinase
G3T16_RS13645	COG1404	Belongs to the peptidase S8 family
G3T16_RS13650	COG1404	Belongs to the peptidase S8 family
G3T16_RS13665	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G3T16_RS13675	COG0425	Belongs to the sulfur carrier protein TusA family
G3T16_RS13700	COG0572	uridine kinase
G3T16_RS13710	COG1215	transferase activity, transferring glycosyl groups
G3T16_RS13715	COG0366	Alpha amylase catalytic
G3T16_RS13730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G3T16_RS13735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3T16_RS13740	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS13755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3T16_RS13760	COG1459	type II secretion system
G3T16_RS13775	COG2165	general secretion pathway protein
G3T16_RS13805	COG1450	Type ii and iii secretion system protein
G3T16_RS13855	COG3695	enzyme binding
G3T16_RS13860	COG3030	protein affecting phage T7 exclusion by the F plasmid
G3T16_RS13865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G3T16_RS13870	COG0459	protein refolding
G3T16_RS13890	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G3T16_RS13890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G3T16_RS13895	COG2925	Exonuclease
G3T16_RS13900	COG0494	nUDIX hydrolase
G3T16_RS13905	COG0728	peptidoglycan biosynthetic process
G3T16_RS13930	COG0174	glutamine synthetase
G3T16_RS13935	COG4771	TonB-dependent receptor
G3T16_RS13950	COG0519	Catalyzes the synthesis of GMP from XMP
G3T16_RS13950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3T16_RS13955	COG0196	riboflavin kinase activity
G3T16_RS13970	COG1047	Peptidyl-prolyl cis-trans
G3T16_RS13975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G3T16_RS13980	COG4969	Belongs to the N-Me-Phe pilin family
G3T16_RS14075	COG0028	Belongs to the TPP enzyme family
G3T16_RS14080	COG0440	acetolactate synthase activity
G3T16_RS14085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G3T16_RS14095	COG1183	phosphatidylcholine synthase activity
G3T16_RS14100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3T16_RS14105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G3T16_RS14155	COG0678	peroxiredoxin activity
G3T16_RS14225	COG4660	Part of a membrane complex involved in electron transport
G3T16_RS14235	COG4658	electron transport chain
G3T16_RS14245	COG2878	Part of a membrane complex involved in electron transport
G3T16_RS14250	COG4657	Part of a membrane complex involved in electron transport
G3T16_RS14255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3T16_RS14255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3T16_RS14280	COG0489	protein tyrosine kinase activity
G3T16_RS14285	COG0717	Belongs to the dCTP deaminase family
G3T16_RS14295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G3T16_RS14300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G3T16_RS14350	COG4221	oxidoreductase activity
G3T16_RS14360	COG0339	signal peptide processing
G3T16_RS14365	COG1506	peptidase
G3T16_RS14365	COG0823	Involved in the tonB-independent uptake of proteins
G3T16_RS14365	COG4946	Tricorn protease homolog
G3T16_RS14370	COG0513	Belongs to the DEAD box helicase family
G3T16_RS14390	COG2361	Protein of unknown function DUF86
G3T16_RS14405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G3T16_RS14410	COG3031	protein transport across the cell outer membrane
G3T16_RS14470	COG0733	neurotransmitter:sodium symporter activity
G3T16_RS14475	COG1115	amino acid carrier protein
G3T16_RS14480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3T16_RS14485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3T16_RS14520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3T16_RS14530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3T16_RS14540	COG0564	pseudouridine synthase activity
G3T16_RS14550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G3T16_RS14560	COG2350	Protein conserved in bacteria
G3T16_RS14565	COG2917	probably involved in intracellular septation
G3T16_RS14575	COG0009	L-threonylcarbamoyladenylate synthase
G3T16_RS14585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G3T16_RS14605	COG1764	response to oxidative stress
G3T16_RS14610	COG0513	Belongs to the DEAD box helicase family
G3T16_RS14615	COG0515	serine threonine protein kinase
G3T16_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS14670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3T16_RS14695	COG4771	TonB-dependent receptor
G3T16_RS14730	COG5001	Diguanylate cyclase
G3T16_RS14730	COG5002	protein histidine kinase activity
G3T16_RS14750	COG4771	TonB-dependent receptor
G3T16_RS14755	COG0402	S-adenosylhomocysteine deaminase activity
G3T16_RS14765	COG0583	DNA-binding transcription factor activity
G3T16_RS14770	COG0527	aspartate kinase activity
G3T16_RS14785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3T16_RS14785	COG0723	plastoquinol--plastocyanin reductase activity
G3T16_RS14800	COG1254	Belongs to the acylphosphatase family
G3T16_RS14810	COG0517	IMP dehydrogenase activity
G3T16_RS14830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3T16_RS14835	COG0512	Glutamine amidotransferase of anthranilate synthase
G3T16_RS14840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G3T16_RS14850	COG3189	MarR family transcriptional regulator
G3T16_RS14915	COG3791	Glutathione-dependent formaldehyde-activating
G3T16_RS14935	COG2814	Major facilitator Superfamily
G3T16_RS14955	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3T16_RS15015	COG4771	TonB-dependent receptor
G3T16_RS15030	COG1228	amidohydrolase
G3T16_RS15040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3T16_RS15055	COG5505	Protein of unknown function (DUF819)
G3T16_RS15060	COG2423	ornithine cyclodeaminase activity
G3T16_RS15100	COG0640	Transcriptional regulator
G3T16_RS15150	COG3189	MarR family transcriptional regulator
G3T16_RS15175	COG2124	cytochrome p450
G3T16_RS15185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G3T16_RS15260	COG0617	tRNA 3'-terminal CCA addition
G3T16_RS15260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G3T16_RS15260	COG3620	sequence-specific DNA binding
G3T16_RS15315	COG0012	GTP binding
G3T16_RS15325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G3T16_RS15330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G3T16_RS15345	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G3T16_RS15355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G3T16_RS15360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G3T16_RS15370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3T16_RS15395	COG2840	Smr protein MutS2
G3T16_RS15410	COG0154	amidase activity
G3T16_RS15415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3T16_RS15420	COG1077	Cell shape determining protein MreB Mrl
G3T16_RS15425	COG1792	Involved in formation and maintenance of cell shape
G3T16_RS15430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G3T16_RS15435	COG0424	maF-like protein
G3T16_RS15440	COG1530	ribonuclease E activity
G3T16_RS15455	COG2239	Acts as a magnesium transporter
G3T16_RS15465	COG1660	Displays ATPase and GTPase activities
G3T16_RS15485	COG1137	ATPase activity
G3T16_RS15490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G3T16_RS15500	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G3T16_RS15520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G3T16_RS15525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G3T16_RS15535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3T16_RS15550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G3T16_RS15555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G3T16_RS15560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G3T16_RS15575	COG0625	glutathione transferase activity
G3T16_RS15580	COG2969	positive regulation of protein catabolic process
G3T16_RS15585	COG2823	Periplasmic or secreted lipoprotein
G3T16_RS15590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G3T16_RS15595	COG0792	nuclease activity
G3T16_RS15615	COG2001	Belongs to the MraZ family
G3T16_RS15625	COG3116	cell division
G3T16_RS15635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G3T16_RS15640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G3T16_RS15645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3T16_RS15650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G3T16_RS15655	COG0772	Belongs to the SEDS family
G3T16_RS15660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G3T16_RS15665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3T16_RS15675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G3T16_RS15690	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G3T16_RS15695	COG0739	heme binding
G3T16_RS15700	COG0653	protein targeting
G3T16_RS15710	COG0494	nUDIX hydrolase
G3T16_RS15715	COG0237	dephospho-CoA kinase activity
G3T16_RS15720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G3T16_RS15750	COG0463	Glycosyl transferase, family 2
G3T16_RS15760	COG0686	Belongs to the AlaDH PNT family
G3T16_RS15780	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS15785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3T16_RS15815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3T16_RS15820	COG5487	UPF0391 membrane protein
G3T16_RS15860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G3T16_RS15865	COG1666	GTP binding
G3T16_RS15890	COG4774	siderophore transport
G3T16_RS15895	COG2199	diguanylate cyclase activity
G3T16_RS15900	COG0288	reversible hydration of carbon dioxide
G3T16_RS15915	COG2046	Belongs to the sulfate adenylyltransferase family
G3T16_RS15920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3T16_RS15940	COG0616	signal peptide processing
G3T16_RS15950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3T16_RS15955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3T16_RS15960	COG0668	transmembrane transport
G3T16_RS15970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3T16_RS15985	COG3008	intermembrane lipid transfer
G3T16_RS15985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G3T16_RS15995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3T16_RS16005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3T16_RS16015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3T16_RS16035	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS16040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3T16_RS16050	COG1393	Belongs to the ArsC family
G3T16_RS16060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G3T16_RS16065	COG0436	Aminotransferase
G3T16_RS16075	COG0024	Methionine aminopeptidase
G3T16_RS16080	COG0052	Belongs to the universal ribosomal protein uS2 family
G3T16_RS16085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G3T16_RS16090	COG0528	UMP kinase activity
G3T16_RS16100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G3T16_RS16110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G3T16_RS16130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3T16_RS16135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3T16_RS16140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3T16_RS16195	COG1522	sequence-specific DNA binding
G3T16_RS16205	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS16220	COG1403	HNH endonuclease
G3T16_RS16260	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G3T16_RS16300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G3T16_RS16305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G3T16_RS16310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3T16_RS16315	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
G3T16_RS16330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3T16_RS16335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G3T16_RS16345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3T16_RS16370	COG1695	Transcriptional regulator
G3T16_RS16380	COG3409	Peptidoglycan-binding domain 1 protein
G3T16_RS16380	COG3267	Type II secretory pathway component ExeA
G3T16_RS16415	COG1984	allophanate hydrolase subunit 2
G3T16_RS16425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G3T16_RS16430	COG4336	lyase activity
G3T16_RS16455	COG0583	DNA-binding transcription factor activity
G3T16_RS16460	COG3091	SprT-like family
G3T16_RS16485	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS16495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3T16_RS16500	COG1024	Enoyl-CoA hydratase
G3T16_RS16505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G3T16_RS16510	COG0084	hydrolase, TatD family'
G3T16_RS16540	COG0525	valine-tRNA ligase activity
G3T16_RS16550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3T16_RS16560	COG0795	lipopolysaccharide-transporting ATPase activity
G3T16_RS16605	COG1902	pentaerythritol trinitrate reductase activity
G3T16_RS16605	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3T16_RS16610	COG3327	negative regulation of DNA-templated transcription, initiation
G3T16_RS16625	COG2030	dehydratase
G3T16_RS16625	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS16635	COG2050	protein possibly involved in aromatic compounds catabolism
G3T16_RS16640	COG0183	Belongs to the thiolase family
G3T16_RS16645	COG3396	Phenylacetate-CoA oxygenase
G3T16_RS16650	COG3460	Phenylacetate-CoA oxygenase
G3T16_RS16655	COG3396	Phenylacetate-CoA oxygenase
G3T16_RS16665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G3T16_RS16670	COG1522	sequence-specific DNA binding
G3T16_RS16700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3T16_RS16720	COG2199	diguanylate cyclase activity
G3T16_RS16720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G3T16_RS16735	COG1522	sequence-specific DNA binding
G3T16_RS16745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3T16_RS16760	COG3300	MHYT domain
G3T16_RS16760	COG5001	Diguanylate cyclase
G3T16_RS16770	COG2197	response regulator
G3T16_RS16775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3T16_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS16790	COG0277	FAD linked oxidase domain protein
G3T16_RS16850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3T16_RS16865	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS16875	COG2072	flavoprotein involved in K transport
G3T16_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
G3T16_RS16895	COG1309	transcriptional regulator
G3T16_RS16900	COG4372	Transposase
G3T16_RS16925	COG4372	Transposase
G3T16_RS16930	COG4771	TonB-dependent receptor
G3T16_RS16940	COG2223	nitrite transmembrane transporter activity
G3T16_RS16945	COG4774	siderophore transport
G3T16_RS16990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3T16_RS17005	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3T16_RS17025	COG1024	Enoyl-CoA hydratase
G3T16_RS17035	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS17040	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS17060	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS17075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G3T16_RS17080	COG0343	queuine tRNA-ribosyltransferase activity
G3T16_RS17085	COG0494	nUDIX hydrolase
G3T16_RS17100	COG4536	flavin adenine dinucleotide binding
G3T16_RS17105	COG4137	Cytochrome C assembly protein
G3T16_RS17115	COG0228	four-way junction DNA binding
G3T16_RS17120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G3T16_RS17125	COG0336	Belongs to the RNA methyltransferase TrmD family
G3T16_RS17130	COG0335	large ribosomal subunit rRNA binding
G3T16_RS17145	COG0436	Aminotransferase
G3T16_RS17160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G3T16_RS17170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G3T16_RS17180	COG2205	protein histidine kinase activity
G3T16_RS17180	COG2202	Pas domain
G3T16_RS17195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3T16_RS17210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3T16_RS17210	COG0519	Catalyzes the synthesis of GMP from XMP
G3T16_RS17250	COG2801	Transposase and inactivated derivatives
G3T16_RS17270	COG0667	Aldo Keto reductase
G3T16_RS17275	COG0640	Transcriptional regulator
G3T16_RS17300	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G3T16_RS17305	COG0659	secondary active sulfate transmembrane transporter activity
G3T16_RS17315	COG2824	Alkylphosphonate utilization operon protein PhnA
G3T16_RS17330	COG1024	Enoyl-CoA hydratase
G3T16_RS17335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3T16_RS17345	COG0723	plastoquinol--plastocyanin reductase activity
G3T16_RS17360	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS17375	COG3119	arylsulfatase activity
G3T16_RS17380	COG4771	TonB-dependent receptor
G3T16_RS17395	COG2084	Dehydrogenase
G3T16_RS17420	COG1309	transcriptional regulator
G3T16_RS17460	COG0477	Major facilitator Superfamily
G3T16_RS17470	COG4774	siderophore transport
G3T16_RS17475	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3T16_RS17495	COG3287	FIST C domain
G3T16_RS17495	COG2200	EAL domain
G3T16_RS17495	COG2199	diguanylate cyclase activity
G3T16_RS17525	COG4221	oxidoreductase activity
G3T16_RS17550	COG1959	2 iron, 2 sulfur cluster binding
G3T16_RS17560	COG2832	Protein of unknown function (DUF454)
G3T16_RS17585	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G3T16_RS17620	COG1104	cysteine desulfurase activity
G3T16_RS17625	COG0105	UTP biosynthetic process
G3T16_RS17630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G3T16_RS17650	COG0124	histidyl-tRNA synthetase
G3T16_RS17655	COG2976	Protein conserved in bacteria
G3T16_RS17665	COG1160	GTP binding
G3T16_RS17685	COG1131	(ABC) transporter
G3T16_RS17700	COG0006	proline dipeptidase activity
G3T16_RS17715	COG3609	addiction module antidote protein, CC2985 family
G3T16_RS17740	COG0419	ATPase involved in DNA repair
G3T16_RS17755	COG3385	transposase activity
G3T16_RS17790	COG2835	tetraacyldisaccharide 4'-kinase activity
G3T16_RS17795	COG0537	adenosine 5'-monophosphoramidase activity
G3T16_RS17800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G3T16_RS17810	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G3T16_RS17880	COG0582	viral genome integration into host DNA
G3T16_RS17915	COG1228	amidohydrolase
G3T16_RS17930	COG0405	Gamma-glutamyltransferase
G3T16_RS17950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G3T16_RS17955	COG0733	neurotransmitter:sodium symporter activity
G3T16_RS17965	COG3712	iron ion homeostasis
G3T16_RS17970	COG4774	siderophore transport
G3T16_RS17990	COG0823	Involved in the tonB-independent uptake of proteins
G3T16_RS17990	COG1506	peptidase
G3T16_RS18015	COG0076	glutamate decarboxylase activity
G3T16_RS18020	COG0583	DNA-binding transcription factor activity
G3T16_RS18055	COG0405	Gamma-glutamyltransferase
G3T16_RS18100	COG4774	siderophore transport
G3T16_RS18125	COG1953	Uracil, thiamine, allantoin
G3T16_RS18130	COG1522	sequence-specific DNA binding
G3T16_RS18135	COG0626	cystathionine gamma-synthase activity
G3T16_RS18140	COG0778	Nitroreductase
G3T16_RS18170	COG4946	Tricorn protease homolog
G3T16_RS18170	COG1506	peptidase
G3T16_RS18170	COG0823	Involved in the tonB-independent uptake of proteins
G3T16_RS18235	COG0596	Alpha beta hydrolase
G3T16_RS18245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G3T16_RS18255	COG1074	ATP-dependent DNA helicase activity
G3T16_RS18275	COG3577	Aspartyl protease
G3T16_RS18280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3T16_RS18280	COG4651	solute:proton antiporter activity
G3T16_RS18285	COG0515	serine threonine protein kinase
G3T16_RS18300	COG0561	phosphatase activity
G3T16_RS18310	COG0154	amidase activity
G3T16_RS18315	COG0436	Aminotransferase
G3T16_RS18325	COG1253	flavin adenine dinucleotide binding
G3T16_RS18350	COG0733	neurotransmitter:sodium symporter activity
G3T16_RS18360	COG4771	TonB-dependent receptor
G3T16_RS18375	COG1012	belongs to the aldehyde dehydrogenase family
G3T16_RS18385	COG0708	Exodeoxyribonuclease III
G3T16_RS18405	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3T16_RS18405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3T16_RS18450	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3T16_RS18460	COG3604	Transcriptional regulator
G3T16_RS18485	COG2986	histidine ammonia-lyase
G3T16_RS18490	COG1228	amidohydrolase
G3T16_RS18505	COG2202	Pas domain
G3T16_RS18505	COG2199	diguanylate cyclase activity
G3T16_RS18505	COG2200	EAL domain
G3T16_RS18510	COG0315	cyclic pyranopterin monophosphate synthase activity
G3T16_RS18515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G3T16_RS18525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3T16_RS18535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3T16_RS18560	COG4771	TonB-dependent receptor
G3T16_RS18570	COG0318	PFAM AMP-dependent synthetase and ligase
G3T16_RS18580	COG1024	Enoyl-CoA hydratase
G3T16_RS18590	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3T16_RS18590	COG0596	Alpha beta hydrolase
G3T16_RS18600	COG1280	lysine exporter protein (LysE YggA)
G3T16_RS18605	COG0720	synthase
G3T16_RS18710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3T16_RS18710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3T16_RS18785	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
G3T16_RS19075	COG4771	TonB-dependent receptor
G3T16_RS19085	COG2814	Major facilitator Superfamily
G3T16_RS19100	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3T16_RS19105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3T16_RS19125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3T16_RS19140	COG0366	Alpha amylase catalytic
G3T16_RS19145	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G3T16_RS19150	COG0517	IMP dehydrogenase activity
G3T16_RS19150	COG1125	glycine betaine transport
G3T16_RS19160	COG4572	Cation transport regulator
G3T16_RS19165	COG1285	pathogenesis
G3T16_RS19170	COG0693	protein deglycase activity
G3T16_RS19240	COG2204	response regulator
G3T16_RS19245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3T16_RS19275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G3T16_RS19285	COG3139	Protein of unknown function (DUF1315)
G3T16_RS19305	COG2304	oxidoreductase activity
G3T16_RS19310	COG2304	oxidoreductase activity
G3T16_RS19335	COG3130	regulation of translation
G3T16_RS19385	COG0741	lytic transglycosylase activity
G3T16_RS19405	COG0023	Translation Initiation Factor
G3T16_RS19445	COG1982	Orn Lys Arg decarboxylase major
G3T16_RS19455	COG0625	glutathione transferase activity
G3T16_RS19460	COG0183	Belongs to the thiolase family
G3T16_RS19465	COG1024	Enoyl-CoA hydratase
G3T16_RS19465	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3T16_RS19470	COG1376	ErfK ybiS ycfS ynhG family protein
G3T16_RS19495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3T16_RS19495	COG0506	proline dehydrogenase activity
G3T16_RS19495	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3T16_RS19510	COG0729	surface antigen
G3T16_RS19530	COG2885	chlorophyll binding
G3T16_RS19545	COG0574	Belongs to the PEP-utilizing enzyme family
G3T16_RS19545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G3T16_RS19560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G3T16_RS19560	COG0116	Belongs to the methyltransferase superfamily
G3T16_RS19575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G3T16_RS19580	COG0066	3-isopropylmalate dehydratase activity
G3T16_RS19585	COG0473	3-isopropylmalate dehydrogenase activity
G3T16_RS19590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G3T16_RS19605	COG0101	tRNA pseudouridine synthase activity
G3T16_RS19610	COG0135	phosphoribosylanthranilate isomerase activity
G3T16_RS19615	COG0133	tryptophan synthase activity
G3T16_RS19620	COG0159	tryptophan synthase activity
G3T16_RS19625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G3T16_RS19630	COG0285	dihydrofolate synthase activity
G3T16_RS19655	COG0714	Associated with various cellular activities
G3T16_RS19720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3T16_RS19735	COG0215	cysteine-tRNA ligase activity
G3T16_RS19740	COG1872	DUF167
G3T16_RS19750	COG0251	oxidation-reduction process
G3T16_RS19800	COG2002	toxin-antitoxin pair type II binding
G3T16_RS19875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G3T16_RS19920	COG3237	CsbD-like
G3T16_RS19935	COG2823	Periplasmic or secreted lipoprotein
G3T16_RS19940	COG1047	Peptidyl-prolyl cis-trans
G3T16_RS19965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G3T16_RS19970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G3T16_RS19975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G3T16_RS19990	COG2983	Belongs to the UPF0260 family
G3T16_RS20005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3T16_RS20015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G3T16_RS20025	COG0589	response to stress
G3T16_RS20050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3T16_RS20060	COG0668	transmembrane transport
G3T16_RS20085	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G3T16_RS20105	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G3T16_RS20115	COG1477	protein flavinylation
G3T16_RS20130	COG1136	(ABC) transporter
G3T16_RS20135	COG4591	ABC-type transport system involved in lipoprotein release permease component
G3T16_RS20155	COG0811	peptide transport
G3T16_RS20160	COG0848	biopolymer transport protein
G3T16_RS20165	COG1132	(ABC) transporter
G3T16_RS20180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G3T16_RS20190	COG0322	excinuclease ABC activity
G3T16_RS20240	COG1090	epimerase
G3T16_RS20255	COG0733	neurotransmitter:sodium symporter activity
G3T16_RS20270	COG3264	Mechanosensitive ion channel
G3T16_RS20270	COG1196	nuclear chromosome segregation
G3T16_RS20285	COG2154	pterin-4-alpha-carbinolamine dehydratase
G3T16_RS20290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3T16_RS20295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3T16_RS20300	COG2920	part of a sulfur-relay system
G3T16_RS20305	COG2168	tRNA wobble position uridine thiolation
G3T16_RS20310	COG2923	Belongs to the DsrF TusC family
G3T16_RS20315	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G3T16_RS20320	COG0670	Belongs to the BI1 family
G3T16_RS20340	COG2186	Transcriptional regulator
G3T16_RS20350	COG4774	siderophore transport
G3T16_RS20355	COG0277	FAD linked oxidase domain protein
G3T16_RS20370	COG4771	TonB-dependent receptor
G3T16_RS20375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G3T16_RS20385	COG0183	Belongs to the thiolase family
G3T16_RS20395	COG0583	DNA-binding transcription factor activity
G3T16_RS20400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3T16_RS20405	COG1960	acyl-CoA dehydrogenase activity
G3T16_RS20410	COG2030	dehydratase
G3T16_RS20430	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G3T16_RS20460	COG1530	ribonuclease E activity
G3T16_RS20465	COG0564	pseudouridine synthase activity
G3T16_RS20475	COG0424	maF-like protein
G3T16_RS20485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G3T16_RS20500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3T16_RS20505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3T16_RS20515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G3T16_RS20530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G3T16_RS20540	COG0544	peptidyl-prolyl cis-trans isomerase activity
G3T16_RS20545	COG0740	serine-type endopeptidase activity
G3T16_RS20550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G3T16_RS20555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3T16_RS20565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3T16_RS20570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3T16_RS20605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3T16_RS20620	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G3T16_RS20620	COG0316	Belongs to the HesB IscA family
G3T16_RS20625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G3T16_RS20645	COG1074	ATP-dependent DNA helicase activity
G3T16_RS20650	COG2813	Specifically methylates the guanine in position
G3T16_RS20655	COG0741	lytic transglycosylase activity
G3T16_RS20655	COG1388	LysM domain
G3T16_RS20665	COG0328	RNA-DNA hybrid ribonuclease activity
G3T16_RS20670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G3T16_RS20675	COG2816	NAD+ diphosphatase activity
G3T16_RS20680	COG0616	signal peptide processing
G3T16_RS20695	COG0189	ligase activity
G3T16_RS20700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans