locus-tag	class	description
HBA47_RS00035	COG2884	Cell division ATP-binding protein ftsE
HBA47_RS00050	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HBA47_RS00055	COG0385	Bile acid
HBA47_RS00070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HBA47_RS00075	COG3676	manually curated
HBA47_RS00080	COG0339	signal peptide processing
HBA47_RS00095	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBA47_RS00115	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HBA47_RS00125	COG1034	ATP synthesis coupled electron transport
HBA47_RS00200	COG2827	Endonuclease containing a URI domain
HBA47_RS00205	COG0859	PFAM glycosyl transferase family 9
HBA47_RS00210	COG0742	ribosomal rna small subunit methyltransferase
HBA47_RS00215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBA47_RS00340	COG0842	Transport permease protein
HBA47_RS00345	COG1131	(ABC) transporter
HBA47_RS00370	COG1538	Outer membrane efflux protein
HBA47_RS00440	COG0791	NLP P60 protein
HBA47_RS00460	COG0840	transmembrane signaling receptor activity
HBA47_RS00545	COG1519	Transferase
HBA47_RS00555	COG2814	Major facilitator Superfamily
HBA47_RS00600	COG1448	Aminotransferase
HBA47_RS00615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBA47_RS00630	COG4221	oxidoreductase activity
HBA47_RS00635	COG3909	cytochrome
HBA47_RS00640	COG0803	Belongs to the bacterial solute-binding protein 9 family
HBA47_RS00645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HBA47_RS00685	COG1177	transmembrane transport
HBA47_RS00690	COG1176	ABC-type spermidine putrescine transport system, permease component I
HBA47_RS00695	COG3842	ATPase activity
HBA47_RS00700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBA47_RS00700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBA47_RS00715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HBA47_RS00720	COG0277	FAD linked oxidase domain protein
HBA47_RS00755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBA47_RS00770	COG2010	Cytochrome c
HBA47_RS00785	COG3278	Belongs to the heme-copper respiratory oxidase family
HBA47_RS00805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS00810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HBA47_RS00835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HBA47_RS00840	COG1297	OPT oligopeptide transporter protein
HBA47_RS00845	COG1530	ribonuclease E activity
HBA47_RS00850	COG3945	hemerythrin HHE cation binding domain
HBA47_RS00865	COG0583	DNA-binding transcription factor activity
HBA47_RS00895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HBA47_RS00930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HBA47_RS00940	COG0196	riboflavin kinase activity
HBA47_RS00950	COG1253	flavin adenine dinucleotide binding
HBA47_RS00990	COG1765	OsmC-like protein
HBA47_RS00995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBA47_RS01010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HBA47_RS01015	COG0544	peptidyl-prolyl cis-trans isomerase activity
HBA47_RS01020	COG2095	MarC family integral membrane protein
HBA47_RS01025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HBA47_RS01035	COG1335	isochorismatase
HBA47_RS01065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HBA47_RS01085	COG3041	Addiction module toxin RelE StbE family
HBA47_RS01095	COG3700	Belongs to the class B bacterial acid phosphatase family
HBA47_RS01115	COG2824	Alkylphosphonate utilization operon protein PhnA
HBA47_RS01195	COG0259	pyridoxamine-phosphate oxidase activity
HBA47_RS01280	COG2201	protein-glutamate methylesterase activity
HBA47_RS01285	COG2198	Histidine kinase
HBA47_RS01285	COG0643	Histidine kinase
HBA47_RS01300	COG0356	it plays a direct role in the translocation of protons across the membrane
HBA47_RS01340	COG0513	Belongs to the DEAD box helicase family
HBA47_RS01345	COG0793	Belongs to the peptidase S41A family
HBA47_RS01350	COG1742	UPF0060 membrane protein
HBA47_RS01360	COG1702	phosphate starvation-inducible protein PhoH
HBA47_RS01365	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBA47_RS01390	COG0348	domain, Protein
HBA47_RS01395	COG3977	Valine--pyruvate aminotransferase
HBA47_RS01400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HBA47_RS01415	COG0339	signal peptide processing
HBA47_RS01425	COG0429	hydrolase of the alpha beta-hydrolase fold
HBA47_RS01430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBA47_RS01455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HBA47_RS01470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HBA47_RS01475	COG2833	Protein of unknown function (DUF455)
HBA47_RS01485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HBA47_RS01490	COG0012	GTP binding
HBA47_RS01500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HBA47_RS01515	COG1505	serine-type exopeptidase activity
HBA47_RS01525	COG1733	regulation of RNA biosynthetic process
HBA47_RS01545	COG0859	PFAM glycosyl transferase family 9
HBA47_RS01550	COG0625	glutathione transferase activity
HBA47_RS01555	COG2969	positive regulation of protein catabolic process
HBA47_RS01580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBA47_RS01600	COG1280	lysine exporter protein (LysE YggA)
HBA47_RS01615	COG4535	Mg2 and Co2 transporter CorC
HBA47_RS01625	COG2807	transmembrane transport
HBA47_RS01660	COG2211	Major facilitator Superfamily
HBA47_RS01665	COG2814	Major facilitator Superfamily
HBA47_RS01670	COG2885	chlorophyll binding
HBA47_RS01765	COG0778	Nitroreductase
HBA47_RS01770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HBA47_RS01845	COG2217	Heavy metal translocating P-type atpase
HBA47_RS01850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBA47_RS01855	COG0640	Transcriptional regulator
HBA47_RS01860	COG2608	mercury ion transmembrane transporter activity
HBA47_RS01865	COG0789	Transcriptional regulator
HBA47_RS01870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HBA47_RS01885	COG0280	phosphate acetyltransferase
HBA47_RS01885	COG0857	belongs to the CobB CobQ family
HBA47_RS01915	COG0799	negative regulation of ribosome biogenesis
HBA47_RS01935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HBA47_RS01950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBA47_RS01960	COG0312	modulator of DNA gyrase
HBA47_RS01965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HBA47_RS01970	COG0287	Prephenate dehydrogenase
HBA47_RS01995	COG1137	ATPase activity
HBA47_RS02000	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HBA47_RS02010	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HBA47_RS02040	COG4178	(ABC) transporter
HBA47_RS02090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HBA47_RS02115	COG0583	DNA-binding transcription factor activity
HBA47_RS02120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HBA47_RS02130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HBA47_RS02165	COG2161	toxin-antitoxin pair type II binding
HBA47_RS02225	COG5433	transposase activity
HBA47_RS02250	COG2161	toxin-antitoxin pair type II binding
HBA47_RS02255	COG4115	mRNA cleavage
HBA47_RS02265	COG2948	multi-organism process
HBA47_RS02270	COG3504	Conjugal transfer protein
HBA47_RS02275	COG3736	Type IV secretory pathway, component VirB8
HBA47_RS02280	COG0551	DNA topoisomerase type I activity
HBA47_RS02280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HBA47_RS02315	COG3451	type IV secretory pathway VirB4
HBA47_RS02335	COG2951	lytic endotransglycosylase activity
HBA47_RS02360	COG1686	Belongs to the peptidase S11 family
HBA47_RS02365	COG2975	iron-sulfur cluster assembly
HBA47_RS02385	COG2350	Protein conserved in bacteria
HBA47_RS02395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBA47_RS02400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HBA47_RS02410	COG4589	Belongs to the CDS family
HBA47_RS02420	COG1289	transmembrane transporter activity
HBA47_RS02425	COG1970	mechanosensitive ion channel activity
HBA47_RS02435	COG1862	Preprotein translocase
HBA47_RS02440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBA47_RS02445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBA47_RS02450	COG0488	(ABC) transporter
HBA47_RS02465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HBA47_RS02470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBA47_RS02485	COG0477	Major facilitator Superfamily
HBA47_RS02490	COG0251	oxidation-reduction process
HBA47_RS02555	COG0494	nUDIX hydrolase
HBA47_RS02560	COG0268	Binds directly to 16S ribosomal RNA
HBA47_RS02570	COG0628	permease
HBA47_RS02580	COG1278	Cold shock
HBA47_RS02590	COG0542	response to heat
HBA47_RS02600	COG1074	ATP-dependent DNA helicase activity
HBA47_RS02615	COG1442	glycosyl transferase family 8
HBA47_RS02615	COG1216	Glycosyl transferase, family 2
HBA47_RS02625	COG1561	YicC-like family, N-terminal region
HBA47_RS02635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBA47_RS02635	COG2813	Specifically methylates the guanine in position
HBA47_RS02655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBA47_RS02660	COG0675	Transposase, IS605 OrfB family
HBA47_RS02690	COG0488	(ABC) transporter
HBA47_RS02730	COG0237	dephospho-CoA kinase activity
HBA47_RS02735	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HBA47_RS02745	COG0009	L-threonylcarbamoyladenylate synthase
HBA47_RS02755	COG2244	polysaccharide biosynthetic process
HBA47_RS02765	COG2089	acid synthase
HBA47_RS02780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HBA47_RS02850	COG1083	cytidylyl-transferase
HBA47_RS02865	COG3676	manually curated
HBA47_RS02890	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HBA47_RS02970	COG1999	signal sequence binding
HBA47_RS02975	COG0737	Belongs to the 5'-nucleotidase family
HBA47_RS02995	COG0121	glutamine amidotransferase
HBA47_RS03005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBA47_RS03010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBA47_RS03020	COG0681	Belongs to the peptidase S26 family
HBA47_RS03030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS03035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HBA47_RS03040	COG1611	Belongs to the LOG family
HBA47_RS03055	COG0546	phosphoglycolate phosphatase activity
HBA47_RS03060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HBA47_RS03060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HBA47_RS03065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS03140	COG1620	l-lactate permease
HBA47_RS03145	COG1139	Iron-sulfur cluster binding protein
HBA47_RS03155	COG0247	lactate metabolic process
HBA47_RS03175	COG0741	lytic transglycosylase activity
HBA47_RS03175	COG1388	LysM domain
HBA47_RS03180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBA47_RS03315	COG4397	Mu-like prophage major head subunit gpT
HBA47_RS03320	COG4388	Caudovirus prohead serine protease
HBA47_RS03325	COG5005	Phage virion morphogenesis
HBA47_RS03340	COG4383	Mu-like prophage protein gp29
HBA47_RS03345	COG1724	mRNA binding
HBA47_RS03350	COG1598	PFAM Uncharacterised protein family UPF0150
HBA47_RS03450	COG2801	Transposase and inactivated derivatives
HBA47_RS03455	COG3423	Transcriptional regulator
HBA47_RS03505	COG0688	phosphatidylethanolamine metabolic process
HBA47_RS03535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBA47_RS03535	COG0543	2 iron, 2 sulfur cluster binding
HBA47_RS03540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBA47_RS03555	COG0307	riboflavin synthase, alpha
HBA47_RS03590	COG0494	nUDIX hydrolase
HBA47_RS03595	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HBA47_RS03595	COG3264	Mechanosensitive ion channel
HBA47_RS03620	COG2866	Carboxypeptidase
HBA47_RS03665	COG1560	Kdo2-lipid A biosynthetic process
HBA47_RS03675	COG5002	protein histidine kinase activity
HBA47_RS03690	COG3676	manually curated
HBA47_RS03725	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HBA47_RS03775	COG1971	Probably functions as a manganese efflux pump
HBA47_RS03800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBA47_RS03805	COG0786	glutamate:sodium symporter activity
HBA47_RS03810	COG2431	L-lysine efflux transmembrane transporter activity
HBA47_RS03830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HBA47_RS03855	COG0739	heme binding
HBA47_RS03880	COG2194	sulfuric ester hydrolase activity
HBA47_RS03885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HBA47_RS03885	COG0517	IMP dehydrogenase activity
HBA47_RS03905	COG2369	cell adhesion
HBA47_RS03950	COG5301	cellulose 1,4-beta-cellobiosidase activity
HBA47_RS04070	COG3118	belongs to the thioredoxin family
HBA47_RS04090	COG1696	Membrane protein involved in D-alanine export
HBA47_RS04115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBA47_RS04125	COG0501	Belongs to the peptidase M48B family
HBA47_RS04150	COG0210	DNA helicase
HBA47_RS04160	COG3038	cytochrome b561
HBA47_RS04175	COG0741	lytic transglycosylase activity
HBA47_RS04185	COG0084	hydrolase, TatD family'
HBA47_RS04200	COG3030	protein affecting phage T7 exclusion by the F plasmid
HBA47_RS04205	COG4942	peptidase
HBA47_RS04225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HBA47_RS04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBA47_RS04250	COG3781	membrane
HBA47_RS04260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HBA47_RS04280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBA47_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
HBA47_RS04325	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HBA47_RS04345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HBA47_RS04365	COG0488	(ABC) transporter
HBA47_RS04375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBA47_RS04400	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBA47_RS04405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HBA47_RS04410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HBA47_RS04430	COG0519	Catalyzes the synthesis of GMP from XMP
HBA47_RS04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBA47_RS04445	COG0277	FAD linked oxidase domain protein
HBA47_RS04470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HBA47_RS04475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HBA47_RS04480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBA47_RS04485	COG0567	Dehydrogenase, E1 component
HBA47_RS04495	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HBA47_RS04500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBA47_RS04505	COG1053	succinate dehydrogenase
HBA47_RS04525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBA47_RS04565	COG2823	Periplasmic or secreted lipoprotein
HBA47_RS04585	COG0110	maltose O-acetyltransferase activity
HBA47_RS04595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HBA47_RS04600	COG1854	S-ribosylhomocysteine lyase activity
HBA47_RS04615	COG3852	Histidine kinase
HBA47_RS04625	COG0714	Associated with various cellular activities
HBA47_RS04635	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HBA47_RS04660	COG0252	asparaginase activity
HBA47_RS04695	COG2217	Heavy metal translocating P-type atpase
HBA47_RS04700	COG0492	ferredoxin-NADP+ reductase activity
HBA47_RS04740	COG0497	DNA recombination
HBA47_RS04765	COG2999	glutathione oxidoreductase activity
HBA47_RS04770	COG0741	lytic transglycosylase activity
HBA47_RS04785	COG3306	glycosyltransferase involved in LPS biosynthesis
HBA47_RS04815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBA47_RS04820	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HBA47_RS04905	COG1215	transferase activity, transferring glycosyl groups
HBA47_RS04935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBA47_RS04945	COG1028	Short-chain dehydrogenase reductase Sdr
HBA47_RS04950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBA47_RS04975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBA47_RS04995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HBA47_RS05145	COG4373	Mu-like prophage FluMu protein gp28
HBA47_RS05160	COG5005	Phage virion morphogenesis
HBA47_RS05220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBA47_RS05235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBA47_RS05300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HBA47_RS05305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HBA47_RS05310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HBA47_RS05315	COG1333	cytochrome c biogenesis protein
HBA47_RS05325	COG0583	DNA-binding transcription factor activity
HBA47_RS05370	COG1196	nuclear chromosome segregation
HBA47_RS05375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HBA47_RS05380	COG1929	Belongs to the glycerate kinase type-1 family
HBA47_RS05425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HBA47_RS05450	COG1466	dna polymerase III delta subunit
HBA47_RS05460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HBA47_RS05470	COG0633	Ferredoxin
HBA47_RS05475	COG0489	protein tyrosine kinase activity
HBA47_RS05485	COG0756	dUTP diphosphatase activity
HBA47_RS05530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBA47_RS05545	COG1187	pseudouridine synthase activity
HBA47_RS05555	COG4456	Virulence-associated protein
HBA47_RS05585	COG0613	PHP domain protein
HBA47_RS05590	COG1160	GTP binding
HBA47_RS05605	COG0730	response to heat
HBA47_RS05610	COG3045	CreA protein
HBA47_RS05640	COG0805	protein transport
HBA47_RS05685	COG1116	anion transmembrane transporter activity
HBA47_RS05700	COG0633	Ferredoxin
HBA47_RS05710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HBA47_RS05715	COG0433	COG0433 Predicted ATPase
HBA47_RS05725	COG0312	modulator of DNA gyrase
HBA47_RS05735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS05745	COG1231	oxidoreductase activity
HBA47_RS05750	COG1215	transferase activity, transferring glycosyl groups
HBA47_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
HBA47_RS05760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HBA47_RS05790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HBA47_RS05830	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HBA47_RS05835	COG2252	PERMEase
HBA47_RS05845	COG0308	aminopeptidase N
HBA47_RS05880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBA47_RS05890	COG2839	Protein conserved in bacteria
HBA47_RS05900	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HBA47_RS05910	COG0586	Pfam SNARE associated Golgi protein
HBA47_RS05915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HBA47_RS05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS05940	COG0513	Belongs to the DEAD box helicase family
HBA47_RS05970	COG0318	PFAM AMP-dependent synthetase and ligase
HBA47_RS06000	COG0305	Participates in initiation and elongation during chromosome replication
HBA47_RS06005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HBA47_RS06070	COG4607	ABC-type enterochelin transport system periplasmic component
HBA47_RS06075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBA47_RS06080	COG4605	iron ion homeostasis
HBA47_RS06100	COG1192	Involved in chromosome partitioning
HBA47_RS06120	COG1116	anion transmembrane transporter activity
HBA47_RS06145	COG0028	Belongs to the TPP enzyme family
HBA47_RS06150	COG0440	acetolactate synthase activity
HBA47_RS06165	COG0802	atpase or kinase
HBA47_RS06215	COG1426	Protein conserved in bacteria
HBA47_RS06230	COG0105	UTP biosynthetic process
HBA47_RS06235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBA47_RS06245	COG1301	dicarboxylic acid transport
HBA47_RS06255	COG0602	queuosine metabolic process
HBA47_RS06260	COG0720	synthase
HBA47_RS06270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBA47_RS06280	COG0708	Exodeoxyribonuclease III
HBA47_RS06340	COG0347	Belongs to the P(II) protein family
HBA47_RS06355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBA47_RS06360	COG1002	Type II restriction enzyme, methylase subunits
HBA47_RS06390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HBA47_RS06395	COG4604	ABC transporter, ATP-binding protein
HBA47_RS06405	COG0493	'glutamate synthase
HBA47_RS06410	COG0070	glutamate synthase
HBA47_RS06410	COG0067	glutamate synthase
HBA47_RS06410	COG0069	glutamate synthase activity
HBA47_RS06430	COG1216	Glycosyl transferase, family 2
HBA47_RS06465	COG0484	heat shock protein binding
HBA47_RS06535	COG0436	Aminotransferase
HBA47_RS06570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HBA47_RS06590	COG0512	Glutamine amidotransferase of anthranilate synthase
HBA47_RS06635	COG1199	ATP-dependent helicase activity
HBA47_RS06645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HBA47_RS06660	COG0163	prenyltransferase activity
HBA47_RS06710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HBA47_RS06745	COG0560	Phosphoserine phosphatase
HBA47_RS06795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS06800	COG0765	amino acid transport
HBA47_RS06805	COG1126	abc transporter atp-binding protein
HBA47_RS06815	COG2878	Part of a membrane complex involved in electron transport
HBA47_RS06860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HBA47_RS06885	COG1652	LysM domain
HBA47_RS06895	COG1619	proteins homologs of microcin C7 resistance protein MccF
HBA47_RS06915	COG0494	nUDIX hydrolase
HBA47_RS06970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBA47_RS07010	COG1610	YqeY-like protein
HBA47_RS07125	COG3201	nicotinamide mononucleotide transporter
HBA47_RS07130	COG1131	(ABC) transporter
HBA47_RS07210	COG2911	Protein conserved in bacteria
HBA47_RS07215	COG0729	surface antigen
HBA47_RS07260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBA47_RS07270	COG2959	enzyme of heme biosynthesis
HBA47_RS07280	COG1187	pseudouridine synthase activity
HBA47_RS07285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HBA47_RS07285	COG0616	signal peptide processing
HBA47_RS07300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HBA47_RS07305	COG0285	dihydrofolate synthase activity
HBA47_RS07315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBA47_RS07320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBA47_RS07380	COG2070	2-Nitropropane dioxygenase
HBA47_RS07415	COG0469	pyruvate kinase activity
HBA47_RS07420	COG2268	Band 7 protein
HBA47_RS07445	COG1091	dTDP-4-dehydrorhamnose reductase activity
HBA47_RS07450	COG1086	Polysaccharide biosynthesis protein
HBA47_RS07480	COG0271	Belongs to the BolA IbaG family
HBA47_RS07515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HBA47_RS07540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HBA47_RS07545	COG1238	metal cluster binding
HBA47_RS07555	COG2056	Na+-H+ antiporter family
HBA47_RS07565	COG0675	Transposase, IS605 OrfB family
HBA47_RS07575	COG0024	Methionine aminopeptidase
HBA47_RS07585	COG0316	Belongs to the HesB IscA family
HBA47_RS07590	COG0822	iron-sulfur transferase activity
HBA47_RS07630	COG0463	Glycosyl transferase, family 2
HBA47_RS07665	COG4139	cobalamin transport
HBA47_RS07670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HBA47_RS07675	COG0569	domain protein
HBA47_RS07680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBA47_RS07685	COG0511	ligase activity, forming carbon-carbon bonds
HBA47_RS07695	COG1346	cytolysis
HBA47_RS07705	COG1049	propionate catabolic process, 2-methylcitrate cycle
HBA47_RS07720	COG3384	dioxygenase
HBA47_RS07735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HBA47_RS07740	COG2354	Protein conserved in bacteria
HBA47_RS07750	COG2204	response regulator
HBA47_RS07755	COG5000	phosphorelay sensor kinase activity
HBA47_RS07785	COG0772	Belongs to the SEDS family
HBA47_RS07790	COG0768	penicillin binding
HBA47_RS07800	COG1792	Involved in formation and maintenance of cell shape
HBA47_RS07805	COG1077	Cell shape determining protein MreB Mrl
HBA47_RS07895	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HBA47_RS07900	COG0523	cobalamin synthesis protein
HBA47_RS07905	COG1966	Carbon starvation protein
HBA47_RS07960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS07980	COG2239	Acts as a magnesium transporter
HBA47_RS08020	COG0084	hydrolase, TatD family'
HBA47_RS08040	COG1183	phosphatidylcholine synthase activity
HBA47_RS08045	COG0494	nUDIX hydrolase
HBA47_RS08060	COG3008	intermembrane lipid transfer
HBA47_RS08060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HBA47_RS08065	COG2995	paraquat-inducible protein a
HBA47_RS08085	COG2610	gluconate transmembrane transporter activity
HBA47_RS08090	COG3265	gluconokinase activity
HBA47_RS08100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HBA47_RS08120	COG1304	FMN binding
HBA47_RS08125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBA47_RS08160	COG0601	transmembrane transport
HBA47_RS08165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBA47_RS08175	COG4608	Belongs to the ABC transporter superfamily
HBA47_RS08185	COG0800	Aldolase
HBA47_RS08210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HBA47_RS08275	COG0542	response to heat
HBA47_RS08290	COG2857	Cytochrome c1
HBA47_RS08295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HBA47_RS08300	COG0723	plastoquinol--plastocyanin reductase activity
HBA47_RS08310	COG2814	Major facilitator Superfamily
HBA47_RS08315	COG0738	Major facilitator superfamily
HBA47_RS08355	COG0039	L-malate dehydrogenase activity
HBA47_RS08370	COG0626	cystathionine gamma-synthase activity
HBA47_RS08375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HBA47_RS08415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HBA47_RS08475	COG0583	DNA-binding transcription factor activity
HBA47_RS08500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBA47_RS08510	COG1530	ribonuclease E activity
HBA47_RS08515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HBA47_RS08520	COG2814	Major facilitator Superfamily
HBA47_RS08560	COG0653	protein targeting
HBA47_RS08565	COG1643	Atp-dependent helicase
HBA47_RS08575	COG1643	Atp-dependent helicase
HBA47_RS08590	COG0745	RESPONSE REGULATOR receiver
HBA47_RS08595	COG3307	-O-antigen
HBA47_RS08625	COG0288	reversible hydration of carbon dioxide
HBA47_RS08655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HBA47_RS08655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBA47_RS08680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBA47_RS08695	COG1216	Glycosyl transferase, family 2
HBA47_RS08700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HBA47_RS08745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HBA47_RS08755	COG0477	Major facilitator Superfamily
HBA47_RS08795	COG2201	protein-glutamate methylesterase activity
HBA47_RS08800	COG0643	Histidine kinase
HBA47_RS08800	COG2198	Histidine kinase
HBA47_RS08820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HBA47_RS08825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBA47_RS08890	COG3676	manually curated
HBA47_RS08945	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HBA47_RS08955	COG2984	ABC transporter substrate binding protein
HBA47_RS08960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HBA47_RS09020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HBA47_RS09025	COG2841	Protein conserved in bacteria
HBA47_RS09055	COG0824	Thioesterase
HBA47_RS09080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HBA47_RS09085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBA47_RS09090	COG1127	ABC transporter
HBA47_RS09120	COG2814	Major facilitator Superfamily
HBA47_RS09125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HBA47_RS09130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HBA47_RS09140	COG0583	DNA-binding transcription factor activity
HBA47_RS09145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HBA47_RS09150	COG1194	a g-specific adenine glycosylase
HBA47_RS09160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBA47_RS09165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBA47_RS09165	COG0678	peroxiredoxin activity
HBA47_RS09170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBA47_RS09180	COG2011	ABC-type metal ion transport system permease component
HBA47_RS09190	COG0586	Pfam SNARE associated Golgi protein
HBA47_RS09245	COG1115	amino acid carrier protein
HBA47_RS09280	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HBA47_RS09325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBA47_RS09340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HBA47_RS09355	COG2837	iron assimilation
HBA47_RS09360	COG1408	metallophosphoesterase
HBA47_RS09365	COG1176	ABC-type spermidine putrescine transport system, permease component I
HBA47_RS09400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HBA47_RS09405	COG2967	ApaG domain
HBA47_RS09430	COG0617	tRNA 3'-terminal CCA addition
HBA47_RS09435	COG1464	Belongs to the NlpA lipoprotein family
HBA47_RS09440	COG1376	ErfK ybiS ycfS ynhG family protein
HBA47_RS09445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HBA47_RS09500	COG0406	alpha-ribazole phosphatase activity
HBA47_RS09505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HBA47_RS09510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HBA47_RS09530	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HBA47_RS09555	COG1476	TRANSCRIPTIONal
HBA47_RS09575	COG0195	Participates in both transcription termination and antitermination
HBA47_RS09575	COG2251	uridine kinase activity
HBA47_RS09585	COG2194	sulfuric ester hydrolase activity
HBA47_RS09650	COG1268	BioY protein
HBA47_RS09660	COG1607	acyl-coa hydrolase
HBA47_RS09740	COG1476	TRANSCRIPTIONal
HBA47_RS09745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HBA47_RS09755	COG0592	DNA-directed DNA polymerase activity
HBA47_RS09780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HBA47_RS09795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBA47_RS09800	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HBA47_RS09800	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HBA47_RS09815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HBA47_RS09815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HBA47_RS09830	COG2962	Rard protein
HBA47_RS09840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HBA47_RS09845	COG0697	spore germination
HBA47_RS09870	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
HBA47_RS09900	COG1393	Belongs to the ArsC family
HBA47_RS09910	COG0733	neurotransmitter:sodium symporter activity
HBA47_RS09945	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HBA47_RS10020	COG2954	triphosphatase activity
HBA47_RS10050	COG3023	N-Acetylmuramoyl-L-alanine amidase
HBA47_RS10060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBA47_RS10080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HBA47_RS10120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HBA47_RS10135	COG0200	Binds to the 23S rRNA
HBA47_RS10200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HBA47_RS10310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBA47_RS10335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBA47_RS10340	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HBA47_RS10355	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HBA47_RS10365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBA47_RS10400	COG1555	photosystem II stabilization
HBA47_RS10435	COG1280	lysine exporter protein (LysE YggA)
HBA47_RS10440	COG1115	amino acid carrier protein
HBA47_RS10450	COG0142	geranyltranstransferase activity
HBA47_RS10465	COG0142	geranyltranstransferase activity
HBA47_RS10505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HBA47_RS10515	COG2086	electron transfer activity
HBA47_RS10530	COG1739	Uncharacterized protein family UPF0029
HBA47_RS10560	COG4774	siderophore transport
HBA47_RS10585	COG3842	ATPase activity
HBA47_RS10595	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HBA47_RS10600	COG0737	Belongs to the 5'-nucleotidase family
HBA47_RS10635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HBA47_RS10635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HBA47_RS10705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family