locus-tag class description F8267_RS00005 ENOG4105NKT exported protein F8267_RS00010 ENOG4108PNC copper resistance F8267_RS00015 ENOG4105FXM Copper resistance protein F8267_RS00020 ENOG4105MPK DNA polymerase III subunit theta F8267_RS00025 ENOG4105UMD exodeoxyribonuclease X F8267_RS00030 ENOG4105CUG Oligopeptidase b F8267_RS00035 ENOG4108Q2J Inner membrane protein YebE F8267_RS00040 ENOG4105X2V dna damage-inducible protein F8267_RS00050 ENOG4108UHU Aldolase F8267_RS00055 ENOG4105C01 Dihydroxy-acid dehydratase F8267_RS00060 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F8267_RS00065 ENOG4106KNT transcriptional regulator F8267_RS00070 ENOG4105CA9 Pyruvate kinase F8267_RS00075 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase F8267_RS00080 ENOG4105DR5 peptidase F8267_RS00085 ENOG4105NXV High-affinity zinc uptake system protein F8267_RS00095 ENOG4105FAV ABC, transporter F8267_RS00100 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) F8267_RS00105 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) F8267_RS00115 ENOG4105CDY transcriptional regulatory protein F8267_RS00120 ENOG4108TIT dATP pyrophosphohydrolase F8267_RS00125 ENOG4105C9M aspartyl-trna synthetase F8267_RS00130 ENOG4105D3W isochorismatase F8267_RS00135 ENOG41081XQ Conserved Protein F8267_RS00140 ENOG4105WJG Glutathione F8267_RS00160 ENOG4106ZCM YecM protein F8267_RS00165 ENOG4105C75 arginyL-tRNA synthetase F8267_RS00170 ENOG4105F5H Glycosyl Hydrolase Family 88 F8267_RS00175 ENOG4105CT4 transporter F8267_RS00180 ENOG4108VA4 Universal stress protein F8267_RS00185 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase F8267_RS00190 ENOG4108K4C ec 3.1.3.12 F8267_RS00195 ENOG4105CNN ABC, transporter F8267_RS00205 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator F8267_RS00210 ENOG4108UEC Ferritin-like protein F8267_RS00215 ENOG4105N4N Protein of unknown function (DUF2766) F8267_RS00220 ENOG4105C0R drug resistance transporter emrb qaca subfamily F8267_RS00230 ENOG41090A1 ferritin F8267_RS00235 ENOG4105VVZ metal-binding protein F8267_RS00240 ENOG4105E0U tyrosine-specific transport protein F8267_RS00245 ENOG4106RHG Yeca family F8267_RS00250 ENOG4105KAF membrAne F8267_RS00255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F8267_RS00285 ENOG4105WH1 Two component transcriptional regulator luxr family F8267_RS00290 ENOG4105XVG cytoplasmic protein F8267_RS00295 ENOG4105VJY transcriptional regulator F8267_RS00300 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F F8267_RS00305 ENOG4105CDA abc transporter atp-binding protein F8267_RS00310 ENOG4105E5Q amino acid AbC transporter F8267_RS00320 ENOG4105EAB amino acid AbC transporter F8267_RS00325 ENOG4105E5K Alpha-amylase F8267_RS00330 ENOG4105JCU Inherit from NOG: (Lipo)protein F8267_RS00345 ENOG4105YX3 cellular response to acidity F8267_RS00355 ENOG4105VNZ cytoplasmic protein F8267_RS00360 ENOG4105CKW Inner membrane protein yedI F8267_RS00365 ENOG4105FDR Membrane F8267_RS00370 ENOG41090BB DNA mismatch endonuclease (vsr) F8267_RS00375 ENOG4105DVF Cytosine-specific methyltransferase F8267_RS00380 ENOG4105EST Metal Dependent Phosphohydrolase F8267_RS00385 ENOG4105Y0K Inner membrane protein YedR F8267_RS00390 ENOG4105FCK Membrane F8267_RS00410 ENOG4108PXI ErfK YbiS YcfS YnhG F8267_RS00415 ENOG4107R11 Transcriptional regulator F8267_RS00430 ENOG4108TSE Transferase F8267_RS00450 ENOG4105FYV Amp nucleosidase F8267_RS00460 ENOG4105CPF Cell wall formation (By similarity) F8267_RS00490 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family F8267_RS00500 ENOG4105UQX Mate efflux family protein F8267_RS00520 ENOG4105ETT transcriptional Regulator, LysR family F8267_RS00530 ENOG4108YS1 cytoplasmic protein F8267_RS00535 ENOG4105BZU Histidine kinase F8267_RS00545 ENOG4105CSH Transporter F8267_RS00550 ENOG4108KMH lipoate-protein ligase a F8267_RS00560 ENOG4107QP6 Xylose isomerase domain protein TIM barrel F8267_RS00565 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein F8267_RS00570 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) F8267_RS00575 ENOG4107QNK )-transporter F8267_RS00585 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) F8267_RS00600 ENOG4108YZT Adenosylcobinamide kinase F8267_RS00610 ENOG4105DR8 Membrane F8267_RS00620 ENOG4105DZ1 carboxypeptidase F8267_RS00625 ENOG4105CJB Exodeoxyribonuclease I F8267_RS00630 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) F8267_RS00635 ENOG4105YVS arsR family transcriptional regulator F8267_RS00640 ENOG4105CUB amino acid F8267_RS00650 ENOG4105EQ1 Transcriptional regulator F8267_RS00655 ENOG4107SRH Nad-dependent epimerase dehydratase F8267_RS00665 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) F8267_RS00670 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) F8267_RS00675 ENOG4105CIH Imidazole acetol-phosphate transaminase F8267_RS00680 ENOG4105ECC imidazole-glycerol-phosphate dehydratase F8267_RS00685 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F8267_RS00700 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase F8267_RS00710 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) F8267_RS00720 ENOG4108KQJ Type 11 methyltransferase F8267_RS00725 ENOG4105EY8 ABC transporter F8267_RS00755 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) F8267_RS00765 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F8267_RS00805 ENOG4105D3Q Sugar transferase F8267_RS00835 ENOG4108MRJ F8267_RS00840 ENOG4105MH5 phosphoesterase PA-phosphatase related protein F8267_RS00845 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F8267_RS00850 ENOG4105EE5 Membrane protein terC F8267_RS00855 ENOG4108GAE asmA family F8267_RS00860 ENOG4105DHP deoxycytidine triphosphate deaminase F8267_RS00865 ENOG4105DBI uridine monophosphokinase F8267_RS00870 ENOG4105D03 DNA-3-methyladenine glycosylase II F8267_RS00875 ENOG4105R8A Heat shock protein F8267_RS00885 ENOG4105ENT Efflux transporter rnd family, mfp subunit F8267_RS00895 ENOG4105BZS acriflavin resistance protein F8267_RS00900 ENOG4105C0R drug resistance transporter emrb qaca subfamily F8267_RS00905 ENOG4105EB3 Histidine kinase F8267_RS00910 ENOG4105E3W Two component transcriptional regulator (Winged helix family F8267_RS00915 ENOG4105CFP Peptidase U32 F8267_RS00925 ENOG4105IE8 Alpha-ketoglutarate permease F8267_RS00930 ENOG4105CMG Carbohydrate kinase F8267_RS00935 ENOG4105DEI Mannitol dehydrogenase F8267_RS00940 ENOG4105DKT Transcriptional regulator F8267_RS00955 ENOG4105CMG Carbohydrate kinase F8267_RS00960 ENOG4105IE8 Alpha-ketoglutarate permease F8267_RS00965 ENOG4105EIE fructose-bisphosphate aldolase F8267_RS00970 ENOG4105DWF phosphomethylpyrimidine kinase F8267_RS00975 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase F8267_RS00990 ENOG4105EUZ Beta-lactamase domain protein F8267_RS01000 ENOG4105EUZ Beta-lactamase domain protein F8267_RS01010 ENOG4105DUM transcriptional regulator, lysR family F8267_RS01015 ENOG4105CPN adenine deaminase F8267_RS01020 ENOG4105C7N Xanthine uracil vitamin C permease F8267_RS01025 ENOG4105EJC lysr family transcriptional regulator F8267_RS01030 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly F8267_RS01040 ENOG4105D1F ATP-binding protein F8267_RS01050 ENOG4106GP0 (LipO)protein F8267_RS01055 ENOG4108W15 Protein of unknown function (DUF1456) F8267_RS01060 ENOG4108NEV two component transcriptional regulator, LytTR family F8267_RS01065 ENOG4108HRK Histidine kinase F8267_RS01070 ENOG4108XDN Transcriptional regulator F8267_RS01080 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component F8267_RS01085 ENOG4108IJ8 ABC transporter F8267_RS01090 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component F8267_RS01095 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system F8267_RS01100 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F8267_RS01105 ENOG4105CXG d-lactate dehydrogenase F8267_RS01115 ENOG41061WM D-Alanyl-D-Alanine F8267_RS01120 ENOG41069YE inner membrane protein yohC F8267_RS01125 ENOG4105KHU inner membrane protein YohD F8267_RS01135 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F8267_RS01140 ENOG4105CS2 ec 3.2.1.21 F8267_RS01155 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) F8267_RS01160 ENOG4105MSY salicylate hydroxylase F8267_RS01165 ENOG4108RXX maleylacetoacetate isomerase F8267_RS01185 ENOG4106KR7 LysR family Transcriptional regulator F8267_RS01190 ENOG4105VAW lrga family F8267_RS01195 ENOG41067MG lrgb family F8267_RS01205 ENOG4107GZ4 SanA protein F8267_RS01210 ENOG4107SDZ Galactoside transport system permease protein mglC F8267_RS01215 ENOG4105C2J ABC transporter F8267_RS01225 ENOG41060NJ transcriptional regulator F8267_RS01230 ENOG4105DHF Membrane F8267_RS01235 ENOG4105EUJ GTP cyclohydrolase i F8267_RS01255 ENOG4105K89 arsenate reductase F8267_RS01260 ENOG4105D05 Receptor F8267_RS01265 ENOG4108IQI permease F8267_RS01270 ENOG4105DUM transcriptional regulator, lysR family F8267_RS01275 ENOG4105HMI Membrane F8267_RS01280 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) F8267_RS01285 ENOG4105DM4 PTS System F8267_RS01290 ENOG4105DE4 1-phosphofructokinase F8267_RS01295 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein F8267_RS01300 ENOG4105S8Q sugar efflux transporter F8267_RS01305 ENOG4105KRS Proteinase inhibitor F8267_RS01315 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) F8267_RS01320 ENOG4105DEI Mannitol dehydrogenase F8267_RS01325 ENOG4105CKI cobalamin synthesis protein F8267_RS01330 ENOG41076MN Phosphoesterase, PA-phosphatase related F8267_RS01335 ENOG4107TT5 NLP P60 protein F8267_RS01340 ENOG4105CXC rtn protein F8267_RS01345 ENOG4105E43 Extracellular solute-binding protein, family 5 F8267_RS01350 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component F8267_RS01355 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component F8267_RS01360 ENOG4108JQ5 ABC transporter F8267_RS01365 ENOG4105HG6 F8267_RS01370 ENOG4105C2C drug resistance transporter, Bcr CflA F8267_RS01375 ENOG4105I08 Pseudouridine synthase F8267_RS01380 ENOG4105CFI type iii restriction protein res subunit F8267_RS01400 ENOG4107VIJ nudix hydrolase F8267_RS01405 ENOG4105E98 transcriptional regulator DeoR family F8267_RS01410 ENOG4106V8H Nucleoid-associated protein F8267_RS01415 ENOG4105PAN UPF0352 protein F8267_RS01420 ENOG4105E68 Sulfatase F8267_RS01430 ENOG4105F4G Membrane F8267_RS01445 ENOG4105CHH sulfate transporter F8267_RS01450 ENOG4105CJW magnesium transporter F8267_RS01455 ENOG4105IBP Cyclic peptide transporter F8267_RS01460 ENOG4105CF1 Alkylated DNA repair protein F8267_RS01465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F8267_RS01480 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC F8267_RS01485 ENOG41068CG regulatoR F8267_RS01490 ENOG4105BZU Histidine kinase F8267_RS01495 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F8267_RS01500 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F8267_RS01505 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F8267_RS01510 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F8267_RS01515 ENOG4105XPH Ferredoxin F8267_RS01525 ENOG4105CXY transporter F8267_RS01530 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A F8267_RS01540 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F8267_RS01545 ENOG4108EWA cinA-like protein F8267_RS01550 ENOG4108UII YfaZ family F8267_RS01560 ENOG4105DHQ Histidine kinase F8267_RS01585 ENOG4105CEY Amp-dependent synthetase and ligase F8267_RS01590 ENOG4105DNI Converts SHCHC to OSB (By similarity) F8267_RS01595 ENOG4108IPT Naphthoate synthase F8267_RS01605 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) F8267_RS01610 ENOG4105E4F Isochorismate synthase F8267_RS01615 ENOG4107YB6 acetyltransferase, (GNAT) family F8267_RS01625 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F8267_RS01630 ENOG4105C8S subunit m F8267_RS01635 ENOG4105D65 subunit l F8267_RS01640 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F8267_RS01645 ENOG4107UFS subunit j F8267_RS01655 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) F8267_RS01660 ENOG4108IEH NADH dehydrogenase subunit g F8267_RS01665 ENOG4107QIZ NADH dehydrogenase F8267_RS01670 ENOG4105GKE subunit e F8267_RS01675 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F8267_RS01680 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F8267_RS01685 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F8267_RS01695 ENOG4107NQ8 LysR family Transcriptional regulator F8267_RS01700 ENOG4105CHM Aminotransferase F8267_RS01705 ENOG4105DK2 UPF0207 protein F8267_RS01710 ENOG4107QWE )-transporter F8267_RS01715 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 F8267_RS01725 ENOG4105PQ6 UPF0208 membrane protein F8267_RS01730 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F8267_RS01735 ENOG4105C6K Malic enzyme F8267_RS01740 ENOG4105PTV Nudix Hydrolase F8267_RS01745 ENOG4108RE9 Phosphodiesterase F8267_RS01750 ENOG4108SHQ Glutathione S-transferase F8267_RS01755 ENOG4105CYM Glutathione S-transferase F8267_RS01760 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase F8267_RS01765 ENOG4105ECP epimerase F8267_RS01785 ENOG4108JEH abc transporter atp-binding protein F8267_RS01790 ENOG4106YG3 ABC transporter F8267_RS01795 ENOG4105DSP amino acid AbC transporter F8267_RS01800 ENOG4105E89 ABC transporter F8267_RS01805 ENOG4105E89 ABC transporter F8267_RS01815 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase F8267_RS01820 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase F8267_RS01825 ENOG4105E96 Colicin v production protein F8267_RS01830 ENOG4108S3P Sporulation domain protein F8267_RS01835 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F8267_RS01840 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) F8267_RS01845 ENOG4105DQR SNARE associated Golgi F8267_RS01850 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F8267_RS01855 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F8267_RS01865 ENOG4106WZ1 flagella biosynthesis regulator F8267_RS01870 ENOG4105F9N Major Facilitator Superfamily F8267_RS01875 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F8267_RS01880 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) F8267_RS01885 ENOG4105MH2 YfcL protein F8267_RS01890 ENOG4108BPE -transporting atpase F8267_RS01895 ENOG4105EJ9 Membrane F8267_RS01900 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) F8267_RS01905 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F8267_RS01910 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) F8267_RS01915 ENOG4108DG9 Smr protein MutS2 F8267_RS01920 ENOG4108BY2 phosphohistidine phosphatase F8267_RS01930 ENOG4105CHU acetyl-coa acetyltransferase F8267_RS01935 ENOG4105KZW UPF0381 protein F8267_RS01940 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation F8267_RS01945 ENOG410903C (LipO)protein F8267_RS01950 ENOG4105S64 Formate nitrite transporter F8267_RS01975 ENOG4107Y2X deaminase F8267_RS01980 ENOG4105DJ2 Major Facilitator Superfamily F8267_RS01990 ENOG4105CHM Aminotransferase F8267_RS01995 ENOG4108HRK Histidine kinase F8267_RS02000 ENOG4105DY9 regulatoR F8267_RS02005 ENOG4105CHC glucokinase (EC 2.7.1.2) F8267_RS02015 ENOG4107RA9 decarboxylase F8267_RS02020 ENOG4105CPC Aldo Keto reductase F8267_RS02025 ENOG4109076 Conserved Protein F8267_RS02030 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) F8267_RS02035 ENOG4105D9N nucleoside F8267_RS02040 ENOG4108KMM Diguanylate cyclase F8267_RS02055 ENOG4105HZG regulatoR F8267_RS02060 ENOG4105GXM Putative transcription regulator (DUF1323) F8267_RS02065 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) F8267_RS02100 ENOG4108M0I Transcriptional regulator F8267_RS02105 ENOG4105DHU Bile acid F8267_RS02110 ENOG4105VRT cytoplasmic protein F8267_RS02125 ENOG4105EXN Sulfate transport protein CysZ F8267_RS02130 ENOG4105C6T cysteine synthase F8267_RS02140 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F8267_RS02145 ENOG4105C5Y PTS System F8267_RS02155 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) F8267_RS02160 ENOG4105CSW GntR family transcriptional regulator F8267_RS02165 ENOG41089BK Glutamine amido-transferase F8267_RS02170 ENOG4105C6T cysteine synthase F8267_RS02175 ENOG4108IJ6 ABC transporter F8267_RS02180 ENOG4105ECW sulfate abc transporter F8267_RS02185 ENOG4108I5D sulfate abc transporter F8267_RS02190 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein F8267_RS02195 ENOG4105EZR dyp-type peroxidase family protein F8267_RS02200 ENOG4105E7K (LipO)protein F8267_RS02205 ENOG4105QZU Inner membrane protein YfeZ F8267_RS02210 ENOG4108R6G acetyltransferase F8267_RS02215 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase F8267_RS02220 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) F8267_RS02225 ENOG4105C6K Malic enzyme F8267_RS02235 ENOG4105CV1 Transketolase (EC 2.2.1.1) F8267_RS02240 ENOG4108PVD exported protein F8267_RS02245 ENOG4107VIJ nudix hydrolase F8267_RS02250 ENOG4105BZ8 glutamate synthase F8267_RS02255 ENOG4105BZS acriflavin resistance protein F8267_RS02265 ENOG4105KUZ arsenate reductase F8267_RS02270 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) F8267_RS02275 ENOG4105XYK UPF0370 protein F8267_RS02280 ENOG4106KED esterase YpfH F8267_RS02290 ENOG4105CGZ zinc metallopeptidase F8267_RS02295 ENOG4105C8V SAICAR synthetase F8267_RS02300 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F8267_RS02305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F8267_RS02310 ENOG4105RH4 Glycine cleavage system transcriptional repressor F8267_RS02315 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F8267_RS02320 ENOG4105C02 permease F8267_RS02325 ENOG4105ERG peptidase m48, ste24p F8267_RS02330 ENOG4105K89 arsenate reductase F8267_RS02340 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) F8267_RS02345 ENOG4105C2W permease F8267_RS02355 ENOG4105CS2 ec 3.2.1.21 F8267_RS02365 ENOG4108V3E phosphoribosylglycinamide formyltransferase F8267_RS02375 ENOG4105CT4 transporter F8267_RS02380 ENOG4105F5H Glycosyl Hydrolase Family 88 F8267_RS02390 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F8267_RS02395 ENOG4105C9X ppx gppa phosphatase F8267_RS02400 ENOG4105BZU Histidine kinase F8267_RS02405 ENOG41062G3 Protein of unknown function (DUF2633) F8267_RS02430 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F8267_RS02435 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F8267_RS02445 ENOG4105D4Y metalloprotease F8267_RS02455 ENOG4105VPD cellular component movement F8267_RS02460 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) F8267_RS02470 ENOG4105N21 Membrane F8267_RS02480 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) F8267_RS02495 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) F8267_RS02500 ENOG4108JQB penicillin-binding protein 1C F8267_RS02505 ENOG4105DN3 alpha-2-macroglobulin domain protein F8267_RS02510 ENOG4105KHC sulfurtransferase F8267_RS02515 ENOG4105YYA enhanced serine sensitivity protein SseB F8267_RS02525 ENOG4105WVQ Fe-S assembly protein IscX F8267_RS02530 ENOG4108ZIT Ferredoxin, 2FE-2S F8267_RS02550 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins F8267_RS02560 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family F8267_RS02565 ENOG4105CVS RNA methyltransferase TrmH family, group 1 F8267_RS02570 ENOG4105ECY inositol monophosphatase F8267_RS02575 ENOG4105D7X high-affinity nickel-transporter F8267_RS02580 ENOG41065CD Exported protein F8267_RS02585 ENOG4108MN2 Stationary phase inducible protein CsiE F8267_RS02590 ENOG4105D8G Major Facilitator superfamily F8267_RS02595 ENOG4108SB3 DoxX Family F8267_RS02605 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F8267_RS02610 ENOG4108YZA Nitrogen regulatory protein pii F8267_RS02615 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F8267_RS02620 ENOG4108SKK alpha helix protein F8267_RS02625 ENOG4107WP9 Histidine kinase F8267_RS02630 ENOG4108ETH Formylglycinamide ribotide synthetase F8267_RS02635 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) F8267_RS02640 ENOG4108Z6B deaminase F8267_RS02645 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB F8267_RS02650 ENOG4106G6Q Transcriptional regulator F8267_RS02655 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding F8267_RS02660 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) F8267_RS02665 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) F8267_RS02670 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) F8267_RS02675 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F8267_RS02680 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) F8267_RS02685 ENOG4105C3F Signal peptidase i F8267_RS02695 ENOG4105WMJ Positive regulator of sigma E, RseC MucC F8267_RS02700 ENOG4105VQK sigma E regulatory protein, MucB RseB F8267_RS02705 ENOG41069PW sigma-e factor negative regulatory protein F8267_RS02720 ENOG4108IYU L-aspartate oxidase F8267_RS02725 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) F8267_RS02730 ENOG4105C1J atp-dependent rna helicase F8267_RS02735 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) F8267_RS02740 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) F8267_RS02745 ENOG4105EIB trna rrna methyltransferase F8267_RS02750 ENOG4105K63 Thioredoxin F8267_RS02755 ENOG4106IUH DTW domain containing protein F8267_RS02760 ENOG4105CD5 CoA-binding domain protein F8267_RS02765 ENOG4105JIM Phosphatidylserine synthase F8267_RS02770 ENOG4105T42 (LipO)protein F8267_RS02775 ENOG4105CSH Transporter F8267_RS02800 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F8267_RS02805 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F8267_RS02810 ENOG4105C34 Pseudouridine synthase F8267_RS02815 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane F8267_RS02820 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA F8267_RS02830 ENOG4105CQC Prephenate dehydratase F8267_RS02840 ENOG4105EHE chorismate mutase- prephenate dehydrogenase F8267_RS02845 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F8267_RS02850 ENOG4108WS1 F8267_RS02855 ENOG4108KHX Diguanylate cyclase F8267_RS02860 ENOG41090EK ompa motb domain protein F8267_RS02880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) F8267_RS02890 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) F8267_RS02895 ENOG4105K5M 30s ribosomal protein S16 F8267_RS02900 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY F8267_RS02905 ENOG4106KVJ cytochrome C assembly protein F8267_RS02910 ENOG4108JU6 CBS domain protein F8267_RS02920 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F8267_RS02925 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F8267_RS02935 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F8267_RS02945 ENOG4108Z1B Cyclase dehydrase F8267_RS02950 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) F8267_RS02975 ENOG4105DB4 F8267_RS03010 ENOG4105NAE bifunctional deaminase-reductase domain protein F8267_RS03025 ENOG4105XDF Protein of unknown function (DUF1272) F8267_RS03035 ENOG4107QY8 reductase F8267_RS03040 ENOG4105CUW cytochrome C-TYPE protein F8267_RS03045 ENOG4105KWW Biogenesis protein F8267_RS03050 ENOG4105KWW Biogenesis protein F8267_RS03055 ENOG4107QX9 Thiol disulfide interChange protein F8267_RS03060 ENOG4105DA4 cytochrome c-type biogenesis protein F8267_RS03070 ENOG4105X3C heme exporter protein F8267_RS03075 ENOG41060IM Heme exporter protein F8267_RS03080 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) F8267_RS03085 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) F8267_RS03095 ENOG4105EGI Transcriptional regulator F8267_RS03100 ENOG4105CY0 Metallo-Beta-Lactamase F8267_RS03105 ENOG4105EWI Short-chain dehydrogenase reductase Sdr F8267_RS03130 ENOG4108UQS dipeptidase F8267_RS03135 ENOG4105DEF Extracellular solute-binding protein, family 5 F8267_RS03140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F8267_RS03145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F8267_RS03150 ENOG4105C3U ABC transporter F8267_RS03155 ENOG4107H6U ABC transporter F8267_RS03160 ENOG4105C26 Dehydrogenase F8267_RS03165 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family F8267_RS03170 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F8267_RS03175 ENOG4105CC0 LysR family Transcriptional regulator F8267_RS03185 ENOG41080HT Transcriptional regulator, arsr family F8267_RS03190 ENOG4108V62 Rhodanese domain protein F8267_RS03205 ENOG4108X73 DNA- binding protein F8267_RS03210 ENOG4108RNS Exports L-alanine (By similarity) F8267_RS03215 ENOG4108WMJ Protein of unknown function (DUF2002) F8267_RS03220 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) F8267_RS03230 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F8267_RS03235 ENOG4105WAZ (Glutaredoxin-like protein) NrdH F8267_RS03240 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) F8267_RS03245 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F8267_RS03250 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F8267_RS03255 ENOG4108IJ7 Glycine betaine F8267_RS03260 ENOG4108HQS Glycine betaine F8267_RS03265 ENOG4105GIJ Glycine betaine F8267_RS03275 ENOG4105NTK Transcriptional repressor Mpra F8267_RS03285 ENOG4105CW7 secretion protein, HlyD family F8267_RS03290 ENOG4105C0R drug resistance transporter emrb qaca subfamily F8267_RS03295 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F8267_RS03300 ENOG4105E7U AraC family transcriptional regulator F8267_RS03310 ENOG4105D9M gamma-glutamylcysteine synthetase F8267_RS03315 ENOG4105W39 Membrane F8267_RS03320 ENOG4107VXZ Hydrolase F8267_RS03325 ENOG4105K3G Periplasmic Protein F8267_RS03355 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) F8267_RS03360 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F8267_RS03375 ENOG4107TH8 cina domain protein F8267_RS03380 ENOG4105DSE periplasmic solute binding protein F8267_RS03385 ENOG4105CC5 ABC transporter F8267_RS03390 ENOG4105DIK (ABC) transporter F8267_RS03395 ENOG4105CVE Lytic murein transglycosylase F8267_RS03400 ENOG410787A Pts system, glucitol sorbitol-specific F8267_RS03405 ENOG4105DZY Pts system, glucitol sorbitol-specific F8267_RS03410 ENOG4105VI0 Pts system, glucitol sorbitol-specific F8267_RS03415 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase F8267_RS03420 ENOG4105J92 DNA-binding transcriptional activator GutM F8267_RS03425 ENOG410804X Transcriptional regulator F8267_RS03440 ENOG4105CNW domain protein F8267_RS03455 ENOG4105C8H hydrogenase maturation protein Hypf F8267_RS03460 ENOG4108RC0 Electron transport protein F8267_RS03465 ENOG4105DDV Transcriptional regulator (LacI family F8267_RS03470 ENOG4105C5Y PTS System F8267_RS03475 ENOG4105CS2 ec 3.2.1.21 F8267_RS03480 ENOG4108MG9 hydrogenase 3 maturation protease F8267_RS03485 ENOG4105I6X formate hydrogenlyase maturation F8267_RS03490 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit F8267_RS03495 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit F8267_RS03500 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F8267_RS03505 ENOG4107TDF Formate hydrogenlyase subunit 4 F8267_RS03510 ENOG4107R30 NADH dehydrogenase F8267_RS03515 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) F8267_RS03520 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA F8267_RS03525 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) F8267_RS03530 ENOG4107RSS Hydrogenase accessory protein HypB F8267_RS03535 ENOG41083WG hydrogenase assembly chaperone F8267_RS03540 ENOG4105CQS hydrogenase expression formation protein HypD F8267_RS03545 ENOG4105C45 hydrogenase expression formation protein (HypE) F8267_RS03560 ENOG4105DIK (ABC) transporter F8267_RS03565 ENOG4105CC5 ABC transporter F8267_RS03570 ENOG4105CC5 ABC transporter F8267_RS03575 ENOG4105VXR cytoplasmic protein F8267_RS03580 ENOG4107R11 Transcriptional regulator F8267_RS03585 ENOG4108N2Y auxin Efflux F8267_RS03605 ENOG4106QJH hemin transport protein F8267_RS03610 ENOG4107R4I Periplasmic binding protein F8267_RS03615 ENOG4105EHG Permease protein F8267_RS03620 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) F8267_RS03625 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) F8267_RS03645 ENOG4105CW0 outer membrane usher protein F8267_RS03650 ENOG4108VCD Chaperone F8267_RS03660 ENOG4105KZM cytoplasmic protein F8267_RS03665 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) F8267_RS03670 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase F8267_RS03680 ENOG4105JQN Transcriptional regulator F8267_RS03690 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F8267_RS03695 ENOG4108K5P (LipO)protein F8267_RS03700 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) F8267_RS03710 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) F8267_RS03715 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) F8267_RS03725 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F8267_RS03730 ENOG4105N0Z inner membrane protein ygbE F8267_RS03735 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) F8267_RS03745 ENOG4105C11 sulfate adenylyltransferase), subunit 2 F8267_RS03750 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F8267_RS03755 ENOG4108MXK alkaline phosphatase isozyme conversion F8267_RS03760 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) F8267_RS03770 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F8267_RS03775 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F8267_RS03780 ENOG4105CHR reductase F8267_RS03785 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F8267_RS03800 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F8267_RS03805 ENOG4105DXN mazG family F8267_RS03810 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F8267_RS03820 ENOG4105BZU Histidine kinase F8267_RS03825 ENOG4105BZW Glycerate kinase F8267_RS03830 ENOG4105EQX glucarate dehydratase F8267_RS03835 ENOG4105EQX glucarate dehydratase F8267_RS03840 ENOG4105DJB Major Facilitator Superfamily F8267_RS03845 ENOG4105QDK Flavodoxin F8267_RS03850 ENOG4105DR9 pseudouridine synthase F8267_RS03855 ENOG4105WP7 tRNA pseudouridine synthase C F8267_RS03860 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) F8267_RS03870 ENOG4105EWT decarboxylase family F8267_RS03875 ENOG4105C44 Serine transporter F8267_RS03880 ENOG4105EJQ L-serine dehydratase F8267_RS03885 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease F8267_RS03895 ENOG4105M08 Membrane F8267_RS03900 ENOG4105ETT transcriptional Regulator, LysR family F8267_RS03905 ENOG4105C9B Cysteine desulfurase F8267_RS03910 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) F8267_RS03915 ENOG4105CUZ uba thif-type nad fad binding protein F8267_RS03920 ENOG4105CA3 membrane-bound lytic murein transglycosylase F8267_RS03940 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F8267_RS03945 ENOG4107QZM n-acetylglutamate synthase F8267_RS03950 ENOG4107QYX exodeoxyribonuclease v alpha F8267_RS03960 ENOG4107QXK peptidase F8267_RS03965 ENOG4105DSY exodeoxyribonuclease V, gamma F8267_RS03975 ENOG4105SEN Protein of unknown function (DUF2509) F8267_RS03980 ENOG4105JCS prepilin peptidase dependent protein F8267_RS03985 ENOG4105IPU prepilin peptidase dependent protein A F8267_RS03990 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) F8267_RS03995 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) F8267_RS04000 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase F8267_RS04015 ENOG4105EE5 Membrane protein terC F8267_RS04020 ENOG4105SUV lipoprotein YgdR F8267_RS04025 ENOG4105CPC Aldo Keto reductase F8267_RS04030 ENOG4107S74 Lysophospholipid transporter LplT F8267_RS04040 ENOG41060NJ transcriptional regulator F8267_RS04050 ENOG4105DDV Transcriptional regulator (LacI family F8267_RS04060 ENOG4105RQF LysR family Transcriptional regulator F8267_RS04075 ENOG4108HKT sucrose-6-phosphate hydrolase F8267_RS04080 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) F8267_RS04085 ENOG4106NDP Transcriptional regulator F8267_RS04090 ENOG4107QNK )-transporter F8267_RS04095 ENOG4105CHR reductase F8267_RS04100 ENOG4105CHU acetyl-coa acetyltransferase F8267_RS04105 ENOG4105DUM transcriptional regulator, lysR family F8267_RS04115 ENOG4108MHD transport protein F8267_RS04120 ENOG4107S5I aldo keto reductase F8267_RS04135 ENOG4108ZHR arsR family transcriptional regulator F8267_RS04150 ENOG4108KTG Membrane protein, drug metabolite transporter F8267_RS04155 ENOG4108ZT1 Transcriptional regulator F8267_RS04165 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F8267_RS04170 ENOG4108KC1 acyl-Coa dehydrogenase F8267_RS04180 ENOG4105FUY alpha subunit F8267_RS04190 ENOG4105CHR reductase F8267_RS04200 ENOG4108VQN 4-hydroxyphenylacetate 3-monooxygenase reductase F8267_RS04215 ENOG4105CW0 outer membrane usher protein F8267_RS04220 ENOG4108MQF Chaperone F8267_RS04225 ENOG41063W2 Fimbrial protein F8267_RS04235 ENOG4105EW9 transcriptional regulator AsnC family F8267_RS04245 ENOG4108W9T type 1 fimbriae regulatory protein F8267_RS04250 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off F8267_RS04255 ENOG4108RQP Major type 1 subunit fimbrin F8267_RS04260 ENOG4108S54 Fimbrial protein F8267_RS04265 ENOG4108NAE Fimbrial chaperone protein F8267_RS04270 ENOG4105CW0 outer membrane usher protein F8267_RS04275 ENOG4108SQA Fimbrial F8267_RS04280 ENOG4108T65 Fimbrial F8267_RS04285 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin F8267_RS04295 ENOG410830R acetyltransferase F8267_RS04300 ENOG4105VR1 Pfam:DUF1271 F8267_RS04310 ENOG4105J12 Multidrug resistance protein mdtN F8267_RS04315 ENOG4108MI0 Resistance protein F8267_RS04320 ENOG4105ETP RND efflux system, outer membrane lipoprotein F8267_RS04325 ENOG4105DUX Transporter F8267_RS04335 ENOG4105CXN decarboxylase F8267_RS04340 ENOG4105D5Q Arginine ornithine antiporter F8267_RS04350 ENOG41061MD high-affinity nickel-transporter F8267_RS04355 ENOG4105WPN DNA integration recombination invertion protein F8267_RS04370 ENOG4105D6F Phosphatase F8267_RS04375 ENOG4105CXY transporter F8267_RS04380 ENOG4105ECY inositol monophosphatase F8267_RS04385 ENOG4105FKQ transcriptional regulator F8267_RS04390 ENOG4107VGR Catalase F8267_RS04400 ENOG4105D5Q Arginine ornithine antiporter F8267_RS04405 ENOG4107SJ9 decarboxylase F8267_RS04410 ENOG4105CUT histidyl-tRNA synthetase F8267_RS04415 ENOG4105CUT histidyl-tRNA synthetase F8267_RS04430 ENOG4108MDY Fimbrial F8267_RS04440 ENOG4108FZ9 Chaperone F8267_RS04445 ENOG4106PG1 outer membrane usher protein F8267_RS04455 ENOG4108TH4 Major fimbrial subunit F8267_RS04490 ENOG41080HJ 6-phospho 3-hexuloisomerase F8267_RS04495 ENOG4105CHR reductase F8267_RS04500 ENOG4105DJV ribulose-phosphate 3-epimerase F8267_RS04505 ENOG4105DT3 PTS system, galactitol-specific IIc component F8267_RS04510 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) F8267_RS04515 ENOG41082GB PTS system galactitol-specific transporter subunit IIA F8267_RS04520 ENOG4105E98 transcriptional regulator DeoR family F8267_RS04525 ENOG4108YZG isomerase F8267_RS04530 ENOG4105DT3 PTS system, galactitol-specific IIc component F8267_RS04535 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) F8267_RS04540 ENOG4105CTS PTS system mannitol-specific F8267_RS04545 ENOG41080HJ 6-phospho 3-hexuloisomerase F8267_RS04590 ENOG4108K5P (LipO)protein F8267_RS04600 ENOG4105CRK lysyL-tRNA synthetase F8267_RS04610 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F8267_RS04615 ENOG4105T95 Thiol disulfide interChange protein F8267_RS04620 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F8267_RS04625 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) F8267_RS04630 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB F8267_RS04635 ENOG4105Y75 tpr repeat protein F8267_RS04645 ENOG4108UT2 hemolysin iii F8267_RS04655 ENOG4108Q3X Transcriptional regulator F8267_RS04660 ENOG4105CS2 ec 3.2.1.21 F8267_RS04680 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F8267_RS04685 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F8267_RS04700 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) F8267_RS04705 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F8267_RS04710 ENOG4105D0A hydroxylase F8267_RS04715 ENOG4107RAQ aminopeptidase F8267_RS04720 ENOG4105E07 UPF0149 protein F8267_RS04735 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F8267_RS04740 ENOG4108JQ1 Dehydrogenase F8267_RS04755 ENOG4105MPN Membrane F8267_RS04760 ENOG4108ZUB Lysine exporter protein (Lyse ygga) F8267_RS04765 ENOG4105D64 Mechanosensitive ion channel F8267_RS04770 ENOG4105D2N Aldolase F8267_RS04785 ENOG4105CV1 Transketolase (EC 2.2.1.1) F8267_RS04790 ENOG4108K0D peptidase, M48 F8267_RS04795 ENOG4105J5J Outer membrane porin F8267_RS04810 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) F8267_RS04815 ENOG4105CHR reductase F8267_RS04835 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase F8267_RS04845 ENOG4108FUF Transcriptional regulator, IclR family F8267_RS04850 ENOG4105CHR reductase F8267_RS04875 ENOG4105CYW agmatinase F8267_RS04900 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP F8267_RS04905 ENOG4107QNK )-transporter F8267_RS04915 ENOG4105RWS endonuclease I F8267_RS04920 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F8267_RS04925 ENOG4105D7Z glutathione synthase F8267_RS04930 ENOG4108UJU UPF0301 protein F8267_RS04940 ENOG41086KC Transcriptional regulator F8267_RS04945 ENOG4105CZX twitching motility protein F8267_RS04950 ENOG4105DFA alanine racemase domain protein F8267_RS04955 ENOG4108VIA integral membrane protein F8267_RS04960 ENOG4105VZ9 UPF0235 protein F8267_RS04970 ENOG4105CSA Coproporphyrinogen iii oxidase F8267_RS04980 ENOG4105C2J ABC transporter F8267_RS04985 ENOG4108HWW ABC transporter F8267_RS04990 ENOG4105K33 Periplasmic Protein F8267_RS04995 ENOG41090ED Protein with unknown function (DUF469) F8267_RS05000 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) F8267_RS05005 ENOG4105CEN a g-specific adenine glycosylase F8267_RS05010 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) F8267_RS05020 ENOG4105EAA nucleoside F8267_RS05025 ENOG4105CXN decarboxylase F8267_RS05030 ENOG4108UQV Membrane F8267_RS05045 ENOG4108WC9 type VI secretion system effector, hcp1 family F8267_RS05050 ENOG4108R66 Conserved Protein F8267_RS05055 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) F8267_RS05065 ENOG4105JHE Major Facilitator Superfamily F8267_RS05075 ENOG4108QBF Transcriptional regulator F8267_RS05090 ENOG4105E93 esterase F8267_RS05100 ENOG4107RNH Outer membrane receptor FepA F8267_RS05110 ENOG4105EP8 Glycosyl Hydrolase Family 88 F8267_RS05125 ENOG4105E7U AraC family transcriptional regulator F8267_RS05130 ENOG4105ETS cytosine purines uracil thiamine allantoin F8267_RS05135 ENOG4105VP5 Bacterial protein of unknown function (DUF937) F8267_RS05140 ENOG4109066 lysm domain bon superfamily protein F8267_RS05145 ENOG4105EJC lysr family transcriptional regulator F8267_RS05155 ENOG4105ETS cytosine purines uracil thiamine allantoin F8267_RS05160 ENOG4105CWC Acetylornithine deacetylase F8267_RS05170 ENOG4105KME endoribonuclease L-psp F8267_RS05175 ENOG4105H3G oxidoreductase F8267_RS05180 ENOG4108KB2 LysR family Transcriptional regulator F8267_RS05185 ENOG4105C26 Dehydrogenase F8267_RS05190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F8267_RS05205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F8267_RS05210 ENOG4106032 Glutathionylspermidine synthase F8267_RS05220 ENOG4105CYM Glutathione S-transferase F8267_RS05225 ENOG4108TEB UPF0114 protein F8267_RS05230 ENOG4108ZZF transport protein (ExbD) F8267_RS05235 ENOG4105CWK Biopolymer transport protein, ExbB F8267_RS05240 ENOG4105C28 cystathionine F8267_RS05245 ENOG4108K81 inner membrane protein YghB F8267_RS05250 ENOG4105CF7 AraC family transcriptional regulator F8267_RS05255 ENOG4108I6A alcohol dehydrogenase F8267_RS05260 ENOG4105CV8 reductase F8267_RS05270 ENOG4105CCT upf0313 protein F8267_RS05275 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) F8267_RS05280 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase F8267_RS05285 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F8267_RS05290 ENOG4105F4I Transcriptional regulator F8267_RS05295 ENOG4105H4F exported protein F8267_RS05300 ENOG4105XJC Two component transcriptional regulator (Winged helix family F8267_RS05305 ENOG4105DHQ Histidine kinase F8267_RS05310 ENOG4105NF4 modulator of drug activity F8267_RS05315 ENOG4105VRH Antibiotic biosynthesis monooxygenase F8267_RS05320 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F8267_RS05325 ENOG4105IPS esterase F8267_RS05330 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) F8267_RS05335 ENOG4108SX3 cytoplasmic protein F8267_RS05340 ENOG41087AY ADP-Ribose pyrophosphatase F8267_RS05350 ENOG4105F1G UPF0441 protein F8267_RS05355 ENOG4106032 Glutathionylspermidine synthase F8267_RS05360 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F8267_RS05370 ENOG4105W0Z cytoplasmic protein F8267_RS05395 ENOG4105I7R Adenylate cyclase F8267_RS05400 ENOG4106MWK domain protein F8267_RS05405 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate F8267_RS05415 ENOG4107ZVW dihydroneopterin aldolase F8267_RS05420 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) F8267_RS05425 ENOG4105C54 Major Facilitator superfamily F8267_RS05440 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F8267_RS05445 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F8267_RS05450 ENOG4108VCA G U mismatch-specific DNA glycosylase F8267_RS05460 ENOG4105V2F Uncharacterized protein yoac F8267_RS05490 ENOG41061MV Arylsulfatase F8267_RS05495 ENOG4105C4X radical SAM domain protein F8267_RS05500 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F8267_RS05535 ENOG4105C4X radical SAM domain protein F8267_RS05540 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) F8267_RS05560 ENOG4105CMT Dihydroxyacetone kinase F8267_RS05565 ENOG4108UTZ Dihydroxyacetone kinase F8267_RS05580 ENOG4105Q26 Siderophore-interacting protein F8267_RS05585 ENOG4105NTW Transcriptional regulator F8267_RS05590 ENOG4105C8Y Acetylornithine aminotransferase F8267_RS05595 ENOG4108Y51 tRNA-binding protein F8267_RS05600 ENOG4105CQ4 Transcriptional regulator F8267_RS05605 ENOG4105CNT hydrolase family 2 F8267_RS05610 ENOG4105FK9 beta-D-galactosidase beta subunit F8267_RS05615 ENOG4105E5D amino acid F8267_RS05620 ENOG4105E5D amino acid F8267_RS05625 ENOG4107W6W Conserved Protein F8267_RS05630 ENOG4107WCA isomerase F8267_RS05635 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound F8267_RS05640 ENOG41061GT Aldolase F8267_RS05645 ENOG4105D4B ABC, transporter F8267_RS05650 ENOG4105F5R ABC transporter F8267_RS05655 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane F8267_RS05660 ENOG4105C2J ABC transporter F8267_RS05665 ENOG4105DKT Transcriptional regulator F8267_RS05670 ENOG4107RYS Autoinducer-2 (AI-2) kinase F8267_RS05675 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F8267_RS05685 ENOG4108VKG metal-dependent hydrolase F8267_RS05690 ENOG4105EE0 oxidoreductase F8267_RS05695 ENOG4105DU1 integral membrane protein, terc F8267_RS05705 ENOG4105CTX dehydratase F8267_RS05715 ENOG4105DPW Major facilitator superfamily MFS_1 F8267_RS05720 ENOG4107YCY Transcriptional regulator F8267_RS05725 ENOG4106W5V Membrane F8267_RS05730 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) F8267_RS05735 ENOG4105WAY exported protein F8267_RS05740 ENOG4105NE1 Conserved Protein F8267_RS05745 ENOG41090KG Inner membrane protein YqjE F8267_RS05750 ENOG4105YJD F8267_RS05760 ENOG4108VBZ doxx family F8267_RS05765 ENOG4105CHF Glutathione S-transferase F8267_RS05770 ENOG4105KAF membrAne F8267_RS05775 ENOG4105CWB LysR family transcriptional Regulator F8267_RS05780 ENOG4108CNN domain protein F8267_RS05790 ENOG4105D64 Mechanosensitive ion channel F8267_RS05800 ENOG4105BZW Glycerate kinase F8267_RS05805 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F8267_RS05810 ENOG4105CNV Aldolase F8267_RS05815 ENOG4105CTX dehydratase F8267_RS05820 ENOG4105E98 transcriptional regulator DeoR family F8267_RS05830 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB F8267_RS05840 ENOG4105F3R pts system mannose fructose sorbose family iid F8267_RS05845 ENOG4108YTN IIa component F8267_RS05850 ENOG4105CE4 GlcNAc 6-P deacetylase F8267_RS05855 ENOG4105E70 isomerase F8267_RS05870 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) F8267_RS05875 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) F8267_RS05885 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) F8267_RS05890 ENOG4105W4M Transport-associated protein F8267_RS05895 ENOG4107S21 permease F8267_RS05900 ENOG4105K4T epimerase F8267_RS05905 ENOG4107R7Y intracellular protease Pfpi family F8267_RS05910 ENOG4108ZPB UPF0306 protein F8267_RS05915 ENOG41082IR Excinuclease ABC C subunit domain protein F8267_RS05920 ENOG4108YYD acetyltransferase F8267_RS05940 ENOG4105DEN Luciferase family F8267_RS05945 ENOG4105CIC tryptophan-specific transport protein F8267_RS05950 ENOG4105C1J atp-dependent rna helicase F8267_RS05965 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) F8267_RS05970 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) F8267_RS05975 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) F8267_RS05980 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) F8267_RS05990 ENOG4105CHV Transcription elongation factor NusA F8267_RS05995 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) F8267_RS06010 ENOG4105CDH Citrulline--aspartate ligase F8267_RS06015 ENOG4108PNB DNA-binding transcriptional regulator F8267_RS06020 ENOG4108UII YfaZ family F8267_RS06035 ENOG4105NTZ Preprotein translocase subunit SecG F8267_RS06040 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) F8267_RS06045 ENOG4105EEI dihydropteroate synthase F8267_RS06050 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F8267_RS06060 ENOG4105HBR Rna-binding protein F8267_RS06065 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) F8267_RS06070 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase F8267_RS06080 ENOG4105QYV Membrane F8267_RS06085 ENOG4105K46 50S ribosomal protein l27 F8267_RS06090 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) F8267_RS06095 ENOG4105EAH synthase F8267_RS06100 ENOG4105HVQ Regulatory factor of maltose metabolism F8267_RS06105 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F8267_RS06110 ENOG4105VFK BolA family F8267_RS06115 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane F8267_RS06120 ENOG4105E3I toluene tolerance F8267_RS06125 ENOG4107PE3 Mammalian cell entry related domain protein F8267_RS06130 ENOG4105CY3 ABC transporter, permease F8267_RS06135 ENOG4105DHJ ABC, transporter F8267_RS06140 ENOG4105FEU K -dependent Na -Ca exchanger F8267_RS06145 ENOG4105C2X Arabinose 5-phosphate isomerase F8267_RS06150 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase F8267_RS06155 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) F8267_RS06160 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA F8267_RS06165 ENOG4108IUZ ABC transporter F8267_RS06170 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F8267_RS06175 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA F8267_RS06180 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN F8267_RS06185 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) F8267_RS06190 ENOG41080Z8 PHOSPHOCARRIER protein F8267_RS06200 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain F8267_RS06205 ENOG4105BZU Histidine kinase F8267_RS06210 ENOG4105N5T Radical SAM Protein F8267_RS06215 ENOG4105CBC glutamate synthase F8267_RS06220 ENOG4105BZ8 glutamate synthase F8267_RS06225 ENOG4105KB2 stringent starvation protein b F8267_RS06230 ENOG4107MKT Stringent starvation protein a F8267_RS06240 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) F8267_RS06245 ENOG4105D6Z AFG1 family ATPase F8267_RS06250 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III F8267_RS06255 ENOG4105C0H protease F8267_RS06260 ENOG4105C0H protease F8267_RS06275 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F8267_RS06280 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) F8267_RS06285 ENOG4105RID UPF0379 protein yhcN F8267_RS06290 ENOG4105RID UPF0379 protein yhcN F8267_RS06295 ENOG4105UNR (Barnase) inhibitor F8267_RS06300 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) F8267_RS06315 ENOG4105CR8 Transcriptional regulator F8267_RS06320 ENOG4105D1U peptidase U62 modulator of DNA gyrase F8267_RS06325 ENOG4105QD6 exported protein F8267_RS06330 ENOG4105C03 ribonuclease F8267_RS06335 ENOG4108Z03 MAF-like protein F8267_RS06340 ENOG4105VQ7 Rod shape-determining protein MreD F8267_RS06345 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) F8267_RS06355 ENOG41062P1 Diguanylate cyclase phosphodiesterase F8267_RS06360 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family F8267_RS06375 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) F8267_RS06380 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein F8267_RS06385 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F8267_RS06390 ENOG4105RG0 Membrane F8267_RS06395 ENOG4108IA2 Sodium pantothenate symporter F8267_RS06405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F8267_RS06415 ENOG4108XG4 DNA-binding transcriptional regulator F8267_RS06420 ENOG4105C1P efflux transporter, rnd family, mfp subunit F8267_RS06425 ENOG4105BZS acriflavin resistance protein F8267_RS06430 ENOG4105XCM membrane LIPOPROTEIN F8267_RS06465 ENOG4108Z0R Transferase F8267_RS06470 ENOG4105SG3 Protein of unknown function (DUF1488) F8267_RS06480 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F8267_RS06485 ENOG4108WI1 Dna topoisomerase F8267_RS06495 ENOG4105C79 DNA protecting protein DprA F8267_RS06505 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F8267_RS06510 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F8267_RS06515 ENOG4105C1A potassium transporter peripheral membrane F8267_RS06520 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) F8267_RS06525 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system F8267_RS06530 ENOG4105W1Y Transcriptional regulator F8267_RS06535 ENOG4105VTS DnaJ-like, subfamily C F8267_RS06540 ENOG4108ZT0 50S ribosomal protein l17 F8267_RS06545 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F8267_RS06550 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) F8267_RS06555 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) F8267_RS06560 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits F8267_RS06565 ENOG41067V7 50S ribosomal protein L36 F8267_RS06570 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F8267_RS06575 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) F8267_RS06580 ENOG4105VPB 50S ribosomal protein L30 F8267_RS06585 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) F8267_RS06630 ENOG41083MP 50s ribosomal protein l29 F8267_RS06635 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) F8267_RS06640 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) F8267_RS06645 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) F8267_RS06650 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) F8267_RS06655 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity F8267_RS06670 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) F8267_RS06685 ENOG4108UQY Iron-storage protein F8267_RS06690 ENOG4105W53 bacterioferritin-associated ferredoxin F8267_RS06695 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F8267_RS06700 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) F8267_RS06705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) F8267_RS06720 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) F8267_RS06725 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) F8267_RS06730 ENOG4105WWK YheO domain protein F8267_RS06735 ENOG4108V1T peptidylprolyl cis-trans isomerase F8267_RS06740 ENOG4105VRX Protein slyX homolog F8267_RS06745 ENOG4108YZY peptidylprolyl cis-trans isomerase F8267_RS06750 ENOG4105VKU nucleicacid-binding protein F8267_RS06760 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F8267_RS06765 ENOG4105C5H ABC transporter F8267_RS06775 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F8267_RS06785 ENOG4105DNZ Alpha Beta Hydrolase F8267_RS06795 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) F8267_RS06800 ENOG4108UKZ OsmC family F8267_RS06805 ENOG4107RYR Transcriptional regulator, Crp Fnr family F8267_RS06810 ENOG410613R integral membrane protein, YccS YhfK family F8267_RS06815 ENOG4105C8Y Acetylornithine aminotransferase F8267_RS06825 ENOG4105MZU cell filamentation protein F8267_RS06830 ENOG4106195 uncharacterized protein yhfG F8267_RS06835 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) F8267_RS06840 ENOG4106DTQ Protein TsgA homolog F8267_RS06845 ENOG4105DZC cytosine deaminase F8267_RS06850 ENOG4107QZF nitrite reductase NADPH large subunit F8267_RS06855 ENOG4105WZK nitrite reductase NADPH small subunit F8267_RS06860 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F8267_RS06865 ENOG4105C31 Tryptophanyl-tRNA synthetase F8267_RS06875 ENOG4105DJV ribulose-phosphate 3-epimerase F8267_RS06880 ENOG4105DFE Dna adenine methylase F8267_RS06885 ENOG4105EGB membrane protein DamX F8267_RS06895 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F8267_RS06900 ENOG4105E4G Type IV pilus F8267_RS06925 ENOG4108JQC penicillin-binding protein 1A F8267_RS06930 ENOG4107RK2 ADP-ribose diphosphatase NudE F8267_RS06935 ENOG4105DQY intracellular growth attenuator F8267_RS06940 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 F8267_RS06945 ENOG4105VEJ Heat shock protein F8267_RS06960 ENOG4105E0F Histidine kinase F8267_RS06970 ENOG4105EDR glucose galactose transporter F8267_RS06975 ENOG4105QJH Domain of unknown function (DUF718) F8267_RS06990 ENOG4105DIA mandelate racemase muconate lactonizing F8267_RS06995 ENOG4105ERH Fumarylacetoacetate hydrolase F8267_RS07000 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr F8267_RS07010 ENOG4108RRZ Transcription elongation factor GreB F8267_RS07015 ENOG4105BZM domain protein F8267_RS07020 ENOG4105XFK Ferrous iron transport protein A F8267_RS07025 ENOG4105CE1 Ferrous iron transport protein b F8267_RS07030 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) F8267_RS07040 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) F8267_RS07045 ENOG4105MJ2 Competence protein F8267_RS07050 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) F8267_RS07055 ENOG4105C6Z Gluconate F8267_RS07060 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) F8267_RS07065 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) F8267_RS07075 ENOG4105E98 transcriptional regulator DeoR family F8267_RS07080 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) F8267_RS07090 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F8267_RS07095 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) F8267_RS07115 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F8267_RS07120 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F8267_RS07125 ENOG4105C6Z Gluconate F8267_RS07130 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family F8267_RS07135 ENOG4105DIQ Transcriptional regulator F8267_RS07140 ENOG4105C2I pirin domain protein F8267_RS07145 ENOG4105D9R oxidoreductase F8267_RS07155 ENOG4105WCN acetyltransferase F8267_RS07160 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) F8267_RS07165 ENOG4105WC8 Conserved Protein F8267_RS07170 ENOG4107T6V glycerophosphoryl diester phosphodiesterase F8267_RS07185 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component F8267_RS07190 ENOG4105BZ7 extracellular solute-binding protein family 1 F8267_RS07200 ENOG41060M8 Pfam:PhdYeFM F8267_RS07205 ENOG4108IV0 ABC, transporter F8267_RS07210 ENOG4105C0Z ABC transporter F8267_RS07215 ENOG4105CF8 branched-chain amino acid ABC transporter, permease F8267_RS07220 ENOG4105C32 Amino acid ABC transporter (Permease) F8267_RS07225 ENOG4105CP9 extracellular ligand-binding receptor F8267_RS07230 ENOG4105U59 -acetyltransferase F8267_RS07235 ENOG4105CP9 extracellular ligand-binding receptor F8267_RS07245 ENOG4105CRP Part of the ABC transporter FtsEX involved in F8267_RS07250 ENOG4105CAK Cell division ATP-binding protein ftsE F8267_RS07255 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F8267_RS07260 ENOG4106H78 methyltransferase F8267_RS07265 ENOG4105MG3 Membrane F8267_RS07275 ENOG4107FS9 Membrane F8267_RS07285 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) F8267_RS07290 ENOG4105EX9 Membrane F8267_RS07295 ENOG4108W1V Lipoprotein F8267_RS07300 ENOG4105F9N Major Facilitator Superfamily F8267_RS07365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F8267_RS07375 ENOG4105C2D reductase F8267_RS07385 ENOG4107YAK holo-(acyl carrier protein) synthase 2 F8267_RS07390 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) F8267_RS07400 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) F8267_RS07405 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) F8267_RS07415 ENOG4105CKK Glycosyl transferase, family 2 F8267_RS07425 ENOG4105PY6 Phenolic acid decarboxylase F8267_RS07435 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein F8267_RS07440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F8267_RS07445 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F8267_RS07475 ENOG4105CJW magnesium transporter F8267_RS07480 ENOG4105CBX hi0933 family F8267_RS07485 ENOG4105CJ3 phosphate transporter F8267_RS07490 ENOG4108V6B universal stress protein B F8267_RS07500 ENOG4105DUX Transporter F8267_RS07505 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) F8267_RS07510 ENOG4105DGW oligopeptidase A F8267_RS07515 ENOG4105D6S protein involved in catabolism of external DNA F8267_RS07520 ENOG4105DC8 reductase F8267_RS07530 ENOG4105CY2 Citrate transporter F8267_RS07540 ENOG4105ETE Transcriptional regulator (LacI family F8267_RS07545 ENOG4108TGY Glutathione S-transferase F8267_RS07550 ENOG4105C0A alcohol dehydrogenase F8267_RS07570 ENOG4106S2D Transcriptional regulator F8267_RS07575 ENOG4105CHR reductase F8267_RS07580 ENOG4105CBN LysR family transcriptional regulator F8267_RS07585 ENOG4107H3J ribonuclease F8267_RS07590 ENOG4105CSH Transporter F8267_RS07595 ENOG41066T0 asmA family F8267_RS07605 ENOG4105CS0 peptidase F8267_RS07615 ENOG4105BZU Histidine kinase F8267_RS07620 ENOG4105EJG cellulose synthase F8267_RS07625 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) F8267_RS07630 ENOG4107EEX Cellulose synthase regulator protein F8267_RS07635 ENOG4107QZ7 Cellulose synthase catalytic subunit F8267_RS07640 ENOG4105UTS cellulose synthase operon protein YhjQ F8267_RS07645 ENOG410661M cytoplasmic protein F8267_RS07650 ENOG4105U74 cellulose biosynthesis protein BcsE F8267_RS07655 ENOG4105WQA Cellulose biosynthesis protein BcsF F8267_RS07660 ENOG4105D1V cellulose synthase operon protein YhjU F8267_RS07680 ENOG4108JQ7 (ABC) transporter F8267_RS07685 ENOG4105C3U ABC transporter F8267_RS07690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F8267_RS07695 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F8267_RS07700 ENOG4105DEF Extracellular solute-binding protein, family 5 F8267_RS07710 ENOG4105DIJ Phosphoethanolamine transferase F8267_RS07715 ENOG4105FCD Major Facilitator F8267_RS07720 ENOG4105EAX Putative lipase F8267_RS07725 ENOG4108R3E Dna-3-methyladenine glycosylase i F8267_RS07730 ENOG4105HNP -acetyltransferase F8267_RS07735 ENOG4107QY8 reductase F8267_RS07740 ENOG4108ZG0 Ompa motb domain protein F8267_RS07745 ENOG4108M60 Transcriptional regulator F8267_RS07755 ENOG4105D7K pfkb domain protein F8267_RS07770 ENOG4106JH6 (LipO)protein F8267_RS07775 ENOG4105D2S major facilitator superfamily F8267_RS07780 ENOG4105MVF Transcriptional regulator F8267_RS07790 ENOG4105C5H ABC transporter F8267_RS07795 ENOG4105C38 Glycyl-tRNA synthetase beta subunit F8267_RS07800 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit F8267_RS07810 ENOG4105MEV Acyl-transferase F8267_RS07815 ENOG410688U Inner membrane protein yiaB F8267_RS07820 ENOG4105CMG Carbohydrate kinase F8267_RS07825 ENOG4105C93 Xylose Isomerase F8267_RS07830 ENOG4105DFW ABC transporter F8267_RS07840 ENOG4108HWW ABC transporter F8267_RS07845 ENOG4105T16 Transcriptional regulator (AraC family) F8267_RS07850 ENOG4108UR8 BAX protein F8267_RS07855 ENOG4107T9C Alpha amylase catalytic region F8267_RS07860 ENOG4105JKW Valine--pyruvate aminotransferase F8267_RS07865 ENOG4108RC0 Electron transport protein F8267_RS07870 ENOG4105C0A alcohol dehydrogenase F8267_RS07875 ENOG4105EM7 Selenocysteine-specific translation elongation factor F8267_RS07880 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) F8267_RS07885 ENOG4108U78 Glutathione S-transferase F8267_RS07890 ENOG4105EFX secretion protein, HlyD family F8267_RS07895 ENOG4105FP6 Protein of unknown function (DUF3302) F8267_RS07900 ENOG4105CTS PTS system mannitol-specific F8267_RS07910 ENOG4105E61 Mannitol repressor protein F8267_RS07915 ENOG41060ND LF82 chromosome, complete sequence F8267_RS07920 ENOG4108YYI Protein of unknown function (DUF2810) F8267_RS07925 ENOG4105DAA L-lactate F8267_RS07930 ENOG41073TP transcriptional regulator F8267_RS07935 ENOG4105DMF Dehydrogenase F8267_RS07940 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F8267_RS07945 ENOG4105D7W serine acetyltransferase F8267_RS07950 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase F8267_RS07955 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) F8267_RS07960 ENOG4105VW4 glutaredoxin 3 F8267_RS07965 ENOG4107YZP Rhodanese domain protein F8267_RS07975 ENOG41063SB peptidase F8267_RS07980 ENOG4105PXI polysaccharide deacetylase F8267_RS07985 ENOG4106WTF Glycosyl transferase, family 2 F8267_RS07995 ENOG4105CPQ Dehydrogenase F8267_RS08000 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F8267_RS08005 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) F8267_RS08010 ENOG4105XA0 heptosyltransferase ii F8267_RS08015 ENOG4105D16 lipopolysaccharide heptosyltransferase i F8267_RS08020 ENOG4105DKP glycosyl transferase, family 9 F8267_RS08025 ENOG4107SBE Glycosyl transferase (Group 1 F8267_RS08040 ENOG4105K64 Glycosyl transferase, family 2 F8267_RS08055 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase F8267_RS08060 ENOG4106WTF Glycosyl transferase, family 2 F8267_RS08065 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) F8267_RS08075 ENOG4105W0E 50S ribosomal protein L33 F8267_RS08080 ENOG4105KDC 50s ribosomal protein l28 F8267_RS08085 ENOG4105W5Q DNA repair protein (RadC F8267_RS08090 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F8267_RS08100 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) F8267_RS08110 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) F8267_RS08115 ENOG4105DSJ YicC domain protein F8267_RS08120 ENOG4105EN6 Membrane F8267_RS08125 ENOG4105DIJ Phosphoethanolamine transferase F8267_RS08130 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) F8267_RS08135 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) F8267_RS08145 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F8267_RS08150 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase F8267_RS08155 ENOG4105CB5 ATP-dependent DNA helicase recG F8267_RS08160 ENOG4105CBT Fructose-1,6-bisphosphatase F8267_RS08165 ENOG4105DP0 ferredoxin-NADP reductase F8267_RS08170 ENOG4108VTS Membrane F8267_RS08175 ENOG4105EBK exported protein F8267_RS08180 ENOG4105CP7 Triose-phosphate isomerase F8267_RS08195 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein F8267_RS08200 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) F8267_RS08205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F8267_RS08215 ENOG4105D6U Sodium Glutamate Symporter F8267_RS08220 ENOG4105C2W permease F8267_RS08225 ENOG4105JV1 AsmA family F8267_RS08230 ENOG4105CI1 PTS System F8267_RS08235 ENOG4105F8D glycoside hydrolase family 4 F8267_RS08250 ENOG4105DKQ ROK family F8267_RS08255 ENOG4105D2N Aldolase F8267_RS08260 ENOG4105D2N Aldolase F8267_RS08265 ENOG4105DM4 PTS System F8267_RS08270 ENOG4108YRF PTS System F8267_RS08275 ENOG4105DM4 PTS System F8267_RS08280 ENOG4105ETD TRANSCRIPTIONal F8267_RS08285 ENOG4105CJQ hydrolase, family 31 F8267_RS08290 ENOG4105CT4 transporter F8267_RS08335 ENOG4105DQ4 alcohol dehydrogenase F8267_RS08345 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein F8267_RS08355 ENOG4105D01 (LipO)protein F8267_RS08360 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) F8267_RS08365 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate F8267_RS08370 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F8267_RS08375 ENOG4105BZS acriflavin resistance protein F8267_RS08380 ENOG4105C1P efflux transporter, rnd family, mfp subunit F8267_RS08390 ENOG410630P Transcriptional regulator F8267_RS08425 ENOG4108UZ3 Transporter F8267_RS08435 ENOG4105DDV Transcriptional regulator (LacI family F8267_RS08445 ENOG4105CK1 PTS System F8267_RS08450 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) F8267_RS08460 ENOG4108MP3 ABC transporter, permease F8267_RS08475 ENOG4106S9K Transcriptional regulator F8267_RS08480 ENOG4107STF Involved in phosphonate degradation (By similarity) F8267_RS08485 ENOG4108KAZ Involved in phosphonate degradation (By similarity) F8267_RS08495 ENOG4108SAJ Protein of unknown function (DUF1198) F8267_RS08500 ENOG4105CXY transporter F8267_RS08505 ENOG4105CXY transporter F8267_RS08510 ENOG4105BZU Histidine kinase F8267_RS08515 ENOG4108KX4 response regulator F8267_RS08520 ENOG4105M71 acetolactate synthase 1 regulatory subunit F8267_RS08525 ENOG4105C7K acetolactate synthase F8267_RS08555 ENOG4105E5M Multidrug resistance protein D F8267_RS08560 ENOG4105W8I Transcriptional regulator F8267_RS08580 ENOG4105JP4 Inner membrane protein yidG F8267_RS08585 ENOG4105VG5 Membrane F8267_RS08590 ENOG4105F8D glycoside hydrolase family 4 F8267_RS08595 ENOG4105CI1 PTS System F8267_RS08600 ENOG4105FDP GntR family transcriptional regulator F8267_RS08605 ENOG4105D0C transport protein F8267_RS08620 ENOG4105R2A (LipO)protein F8267_RS08625 ENOG4105D99 atp gtp-binding protein F8267_RS08630 ENOG4105DJB Major Facilitator Superfamily F8267_RS08635 ENOG4105CXK mandelate racemase muconate lactonizing F8267_RS08640 ENOG4108RTU Aldolase F8267_RS08645 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 F8267_RS08650 ENOG4105EMF GntR family transcriptional regulator F8267_RS08665 ENOG410667J hydrolase F8267_RS08670 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F8267_RS08675 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) F8267_RS08680 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F8267_RS08690 ENOG4105VG0 50S ribosomal protein l34 F8267_RS08700 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) F8267_RS08705 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F8267_RS08720 ENOG4105G2Y Transcriptional regulator F8267_RS08725 ENOG4105E8Q phosphopantetheinyl transferase F8267_RS08730 ENOG4108YYH Nadph-dependent fmn reductase F8267_RS08735 ENOG4105C7N Xanthine uracil vitamin C permease F8267_RS08745 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 F8267_RS08750 ENOG4107VKM 6-phosphogluconolactonase F8267_RS08755 ENOG4105DYC esterase F8267_RS08770 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F8267_RS08775 ENOG4105E2Z phosphate ABC transporter (Permease F8267_RS08780 ENOG4105C8U phosphate abc transporter F8267_RS08785 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) F8267_RS08795 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F8267_RS08800 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) F8267_RS08805 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) F8267_RS08810 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) F8267_RS08820 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) F8267_RS08845 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation F8267_RS08855 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) F8267_RS08860 ENOG4105QTB Flavodoxin F8267_RS08865 ENOG4108VVK transcriptional Regulator, AsnC F8267_RS08870 ENOG4105CU9 asparagine synthetase A F8267_RS08875 ENOG4105EV2 VWA domain protein interacting with AAA ATPase F8267_RS08895 ENOG4105C2J ABC transporter F8267_RS08900 ENOG4105CNN ABC, transporter F8267_RS08905 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F8267_RS08910 ENOG4108RVA ribokinase F8267_RS08915 ENOG4105ETE Transcriptional regulator (LacI family F8267_RS08920 ENOG4105C0R drug resistance transporter emrb qaca subfamily F8267_RS08925 ENOG4107EJG GntR family transcriptional regulator F8267_RS08970 ENOG4108WFC UPF0438 protein yifE F8267_RS08975 ENOG4105C0P Mg chelatase subunit ChlI F8267_RS08990 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit F8267_RS08995 ENOG4105CM2 brancheD-chain amino acid aminotransferase F8267_RS09005 ENOG4105C7B Threonine dehydratase F8267_RS09010 ENOG4105EMY transcriptional regulator F8267_RS09020 ENOG4105KQ5 peptidylprolyl cis-trans isomerase F8267_RS09025 ENOG4105KQ5 peptidylprolyl cis-trans isomerase F8267_RS09030 ENOG4105C4R Atp-dependent dna helicase F8267_RS09035 ENOG4108UQV Membrane F8267_RS09045 ENOG4105G2Y Transcriptional regulator F8267_RS09055 ENOG4105C1J atp-dependent rna helicase F8267_RS09065 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F8267_RS09070 ENOG4105ESV Glycosyl transferase, family 4 F8267_RS09075 ENOG4105SFE lipopolysaccharide biosynthesis protein F8267_RS09080 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F8267_RS09085 ENOG4107QQG Dehydrogenase F8267_RS09090 ENOG4105C1B dTDP-glucose 4-6-dehydratase F8267_RS09095 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) F8267_RS09100 ENOG4108WJ1 acetyltransferase F8267_RS09105 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F8267_RS09110 ENOG4105EGZ biosynthesis protein F8267_RS09115 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) F8267_RS09120 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) F8267_RS09125 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family F8267_RS09130 ENOG4105C85 amino acid F8267_RS09160 ENOG410601J HemY protein F8267_RS09165 ENOG4105ECF c-methyltransferase F8267_RS09170 ENOG41076E6 Uroporphyrinogen-III Synthase F8267_RS09180 ENOG4107T0K Adenylate cyclase F8267_RS09185 ENOG4105XQ6 frataxin-like protein F8267_RS09190 ENOG4105S7Z (LipO)protein F8267_RS09200 ENOG4105CT0 Protein of unknown function, DUF484 F8267_RS09205 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F8267_RS09210 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant F8267_RS09215 ENOG4105C4R Atp-dependent dna helicase F8267_RS09220 ENOG4107QUT magnesium and cobalt transport protein CorA F8267_RS09225 ENOG4105FR1 rard protein F8267_RS09230 ENOG4108VUY thioesterase Superfamily protein F8267_RS09235 ENOG4105HDD phospholipase F8267_RS09240 ENOG4105C9U ATP-dependent DNA helicase RecQ F8267_RS09245 ENOG4105CCF Lysine exporter protein (Lyse ygga) F8267_RS09255 ENOG410829K Lysine exporter protein (Lyse ygga) F8267_RS09260 ENOG4108EUD Lysophospholipase F8267_RS09265 ENOG4105DQF Hydrolase F8267_RS09270 ENOG4105EMK carboxylate amino acid amine transporter F8267_RS09275 ENOG4105DZ2 Transcriptional regulator F8267_RS09285 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) F8267_RS09290 ENOG4107SXA Phosphorylase F8267_RS09295 ENOG4105CGY Dna recombination protein F8267_RS09300 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F8267_RS09305 ENOG4105JC1 sterol-binding domain protein F8267_RS09310 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F8267_RS09315 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) F8267_RS09320 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) F8267_RS09325 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F8267_RS09335 ENOG4105MDZ Transcriptional activator rfaH F8267_RS09345 ENOG4107QK7 reductase F8267_RS09350 ENOG4105CHU acetyl-coa acetyltransferase F8267_RS09360 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) F8267_RS09365 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein F8267_RS09370 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) F8267_RS09375 ENOG4108RR8 protoporphyrinogen oxidase F8267_RS09400 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b F8267_RS09405 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) F8267_RS09410 ENOG4105PC1 Conserved Protein F8267_RS09415 ENOG4105E27 serine threonine protein kinase F8267_RS09420 ENOG4108Z33 Thiol disulfide Interchange Protein F8267_RS09425 ENOG4106HNH Acyl-transferase F8267_RS09430 ENOG4105C2M dna polymerase I F8267_RS09440 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) F8267_RS09445 ENOG4105D4P Coproporphyrinogen iii oxidase F8267_RS09450 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F8267_RS09455 ENOG4105CUX Signal transduction histidine kinase F8267_RS09460 ENOG4105C5F glutamine synthetase F8267_RS09465 ENOG4105CI3 gtp-binding protein typa F8267_RS09470 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 F8267_RS09475 ENOG4107S2Z UPF0761 membrane protein F8267_RS09485 ENOG4105SUU thioesterase domain F8267_RS09495 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) F8267_RS09500 ENOG4108MG3 formate dehydrogenase F8267_RS09505 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein F8267_RS09515 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F8267_RS09530 ENOG4108UMN azlc family F8267_RS09540 ENOG4108RVA ribokinase F8267_RS09545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F8267_RS09550 ENOG4108R66 Conserved Protein F8267_RS09555 ENOG4108I5G Major Facilitator superfamily F8267_RS09565 ENOG4105C0A alcohol dehydrogenase F8267_RS09570 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) F8267_RS09590 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) F8267_RS09600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F8267_RS09605 ENOG4108RPX mosc domain containing protein F8267_RS09610 ENOG4105E0F Histidine kinase F8267_RS09615 ENOG4105E3W Two component transcriptional regulator (Winged helix family F8267_RS09620 ENOG4105FMW periplasmic F8267_RS09625 ENOG41076HS cation diffusion facilitator family transporter F8267_RS09630 ENOG4105CTQ phosphohexokinase F8267_RS09635 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) F8267_RS09640 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F8267_RS09645 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) F8267_RS09650 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) F8267_RS09655 ENOG41063M6 Cell Division Protein F8267_RS09660 ENOG4105ETE Transcriptional regulator (LacI family F8267_RS09665 ENOG4105C25 Primosomal protein n' F8267_RS09670 ENOG4105VFB Binds the 23S rRNA (By similarity) F8267_RS09680 ENOG4105C28 cystathionine F8267_RS09685 ENOG4105CFH Aspartokinase F8267_RS09690 ENOG4105SYT Methylenetetrahydrofolate reductase F8267_RS09695 ENOG4108Q5Y Membrane F8267_RS09700 ENOG4105DCT glycerol dehydrogenase F8267_RS09705 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F8267_RS09710 ENOG4106R3P AraC family transcriptional regulator F8267_RS09715 ENOG4108MEK Metal-binding protein YodA F8267_RS09725 ENOG4105CWC Acetylornithine deacetylase F8267_RS09730 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase F8267_RS09735 ENOG4105CAS nag kinase F8267_RS09740 ENOG4105CH7 arginosuccinase F8267_RS09745 ENOG4105C5Q Transcriptional regulator F8267_RS09750 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) F8267_RS09755 ENOG4105EJ2 Transcriptional regulator F8267_RS09760 ENOG4108Y73 Membrane F8267_RS09770 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F8267_RS09810 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase F8267_RS09840 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F8267_RS09845 ENOG4105PM1 preprotein translocase subunit SecE F8267_RS09850 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F8267_RS09865 ENOG4108VZM 50s ribosomal protein L10 F8267_RS09870 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) F8267_RS09880 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F8267_RS09885 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F8267_RS09890 ENOG4105VCP PTS System F8267_RS09900 ENOG4106TD9 Diguanylate cyclase F8267_RS09905 ENOG4105D41 biosynthesis protein thiH F8267_RS09915 ENOG4105WHD thiamine biosynthesis protein ThiS F8267_RS09920 ENOG4105D06 uba thif-type nad fad binding protein F8267_RS09925 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) F8267_RS09935 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) F8267_RS09955 ENOG4105R2J Conserved Protein F8267_RS09960 ENOG4105K70 DNA-binding protein F8267_RS09965 ENOG4108T8B Protein of unknown function (DUF1481) F8267_RS09975 ENOG4105BZU Histidine kinase F8267_RS09985 ENOG4105C12 Phosphoribosylglycinamide synthetase F8267_RS10015 ENOG41062WK cellular response to acidity F8267_RS10020 ENOG4105CVG Homoserine O-transsuccinylase F8267_RS10025 ENOG4107QP3 malate synthase g F8267_RS10030 ENOG4108I9X Isocitrate lyase F8267_RS10035 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) F8267_RS10040 ENOG41069M3 Transcriptional regulator F8267_RS10045 ENOG4105C3R Methionine synthase F8267_RS10050 ENOG4105EAM Na Pi-cotransporter F8267_RS10060 ENOG4105N0E Protein of unknown function (DUF2543) F8267_RS10065 ENOG4105FE9 pseudouridine synthase F8267_RS10070 ENOG4108ZR5 Conserved Protein F8267_RS10075 ENOG4105C09 Bile acid F8267_RS10080 ENOG4105CYB regulatoR F8267_RS10090 ENOG4105E0Y RtcB Protein F8267_RS10095 ENOG410756H nucleotidyltransferase F8267_RS10100 ENOG4105CFH Aspartokinase F8267_RS10105 ENOG4107QP8 phosphohexose isomerase F8267_RS10110 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) F8267_RS10115 ENOG4105KME endoribonuclease L-psp F8267_RS10130 ENOG4105CEM UPF0597 protein F8267_RS10135 ENOG4108VY7 phosphate-starvation-inducible protein PsiE F8267_RS10140 ENOG4105EG2 ABC transporter, permease F8267_RS10145 ENOG4105D56 permease protein F8267_RS10150 ENOG4107FKK extracellular solute-binding protein family 1 F8267_RS10155 ENOG4108IJ9 (ABC) transporter F8267_RS10160 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) F8267_RS10165 ENOG4107W52 maltose operon periplasmic protein F8267_RS10170 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) F8267_RS10175 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) F8267_RS10180 ENOG4105E55 glycerol-3-phosphate acyltransferase F8267_RS10185 ENOG41080IJ Diacylglycerol kinase F8267_RS10195 ENOG4107R73 Mate efflux family protein F8267_RS10200 ENOG4105VDW Csbd family F8267_RS10205 ENOG4105MYN Zinc uptake regulation protein F8267_RS10215 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F8267_RS10220 ENOG4105P4Z Phage shock protein G F8267_RS10225 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F8267_RS10230 ENOG4105CDU Replicative dna helicase F8267_RS10235 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F8267_RS10240 ENOG4105CGF Aromatic amino acid aminotransferase F8267_RS10250 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme F8267_RS10255 ENOG4105MSB protein, conserved in bacteria F8267_RS10270 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F8267_RS10275 ENOG4108UUM single-stranded DNA-binding protein F8267_RS10295 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) F8267_RS10305 ENOG4105PMV Membrane F8267_RS10310 ENOG4108M8H domain protein F8267_RS10315 ENOG4108W3Q Transcriptional regulator F8267_RS10320 ENOG4108Z4X TRANSCRIPTIONal F8267_RS10325 ENOG4108K3A Glutathione S-transferase F8267_RS10330 ENOG4105C7N Xanthine uracil vitamin C permease F8267_RS10335 ENOG4105EEQ Na H antiporter F8267_RS10340 ENOG4105CMU LysR family (Transcriptional regulator F8267_RS10345 ENOG4105VAW lrga family F8267_RS10350 ENOG41067MG lrgb family F8267_RS10360 ENOG4105MX3 Fimbrial F8267_RS10365 ENOG4108AF8 Chaperone F8267_RS10370 ENOG4105CW0 outer membrane usher protein F8267_RS10375 ENOG4108SQA Fimbrial F8267_RS10380 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin F8267_RS10385 ENOG4107QN1 sodium solute F8267_RS10390 ENOG41062QD Membrane F8267_RS10395 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F8267_RS10400 ENOG4105CK2 sodium dicarboxylate symporter F8267_RS10405 ENOG41082ND Uncharacterized protein yjcO F8267_RS10425 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F8267_RS10430 ENOG4105CNN ABC, transporter F8267_RS10435 ENOG4105C2J ABC transporter F8267_RS10440 ENOG4105BZU Histidine kinase F8267_RS10450 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein F8267_RS10455 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) F8267_RS10460 ENOG4105FD8 phosphonate metabolism protein PhnM F8267_RS10465 ENOG4105HRV phosphonate c-p lyase system protein phnl F8267_RS10470 ENOG4105ENV phosphonate C-P lyase system protein PhnK F8267_RS10475 ENOG4105FT8 Phosphonate metabolism F8267_RS10480 ENOG4105EKV Phosphonate metabolism protein F8267_RS10485 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH F8267_RS10490 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG F8267_RS10495 ENOG4107RJJ Transcriptional regulator F8267_RS10500 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase F8267_RS10505 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F8267_RS10510 ENOG4105CSH Transporter F8267_RS10515 ENOG4108K2B transcriptional regulator F8267_RS10520 ENOG4105F8D glycoside hydrolase family 4 F8267_RS10525 ENOG4105CT4 transporter F8267_RS10550 ENOG4108ZCF integral membrane protein F8267_RS10565 ENOG4105CND Glycosyl transferase, family 2 F8267_RS10570 ENOG4107BJW polysaccharide deacetylase F8267_RS10575 ENOG4108TUY outer membrane protein PgaA F8267_RS10610 ENOG4108SIC Transcriptional regulator F8267_RS10615 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) F8267_RS10625 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F8267_RS10630 ENOG4108IJ0 Aspartate ammonia-lyase F8267_RS10635 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 F8267_RS10640 ENOG4105DVH amino acid F8267_RS10650 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) F8267_RS10655 ENOG4108ZVF (LipO)protein F8267_RS10660 ENOG4105MTB Uncharacterized protein YjeJ F8267_RS10665 ENOG4108JJA ABC, transporter F8267_RS10670 ENOG4108MBX Secretion Protein F8267_RS10685 ENOG4105CW0 outer membrane usher protein F8267_RS10705 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F8267_RS10710 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) F8267_RS10720 ENOG4106BSU Entericidin B F8267_RS10725 ENOG4105KPY Small multidrug resistance protein F8267_RS10735 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) F8267_RS10745 ENOG4105E33 succinate dehydrogenase F8267_RS10750 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) F8267_RS10760 ENOG4107SC7 Inner membrane transporter yjeM F8267_RS10765 ENOG4105EGS Mechanosensitive ion channel F8267_RS10770 ENOG4105DJ4 phosphatidylserine decarboxylase F8267_RS10780 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) F8267_RS10785 ENOG4106TNF Periplasmic binding protein F8267_RS10805 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F8267_RS10810 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) F8267_RS10815 ENOG4105K8N protein family UPF0079, ATPase F8267_RS10820 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F8267_RS10825 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) F8267_RS10830 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) F8267_RS10840 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F8267_RS10845 ENOG4107QJR hflk protein F8267_RS10850 ENOG4105EPW hflc protein F8267_RS10860 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis F8267_RS10865 ENOG4105KPV Transcriptional regulator F8267_RS10870 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F8267_RS10875 ENOG4105C2N RNA methyltransferase TrmH family group 3 F8267_RS10880 ENOG4105CSH Transporter F8267_RS10885 ENOG4105CSU acyl-Coa dehydrogenase F8267_RS10890 ENOG4105S17 UPF0379 protein yjfN F8267_RS10895 ENOG4105WSB biofilm stress and motility protein A F8267_RS10900 ENOG4108MXZ Esterase F8267_RS10915 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC F8267_RS10925 ENOG4106ETB IIa component F8267_RS10950 ENOG4105KIT UPF0379 protein yjfY F8267_RS10960 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) F8267_RS10965 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) F8267_RS10970 ENOG4105K9Q Binds to the 23S rRNA (By similarity) F8267_RS10980 ENOG4105FHY Opacity-associated protein A F8267_RS10985 ENOG4108V1T peptidylprolyl cis-trans isomerase F8267_RS11000 ENOG4105DXC membrane F8267_RS11010 ENOG4105ECR NmrA family F8267_RS11015 ENOG4105KVH Transcriptional regulator F8267_RS11020 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic F8267_RS11025 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase F8267_RS11030 ENOG4108UUE Transcriptional regulator F8267_RS11035 ENOG41061GZ Protein of unknown function (DUF1107) F8267_RS11040 ENOG4105C37 (CBS) domain F8267_RS11050 ENOG4105CFU surface antigen F8267_RS11055 ENOG4105MA0 exported protein F8267_RS11060 ENOG4108ZHD aig2 family F8267_RS11065 ENOG4105F0N pyrophosphate phospho-hydrolase F8267_RS11070 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator F8267_RS11075 ENOG4105C2J ABC transporter F8267_RS11080 ENOG4107R9N ABC transporter F8267_RS11085 ENOG41062B0 ABC transporter, permease F8267_RS11095 ENOG4105DFU Cell wall formation (By similarity) F8267_RS11105 ENOG4105N42 UPF0307 protein F8267_RS11110 ENOG4105CMS peptidase U62, modulator of DNA gyrase F8267_RS11115 ENOG4108XVM Cytochrome b(562) F8267_RS11145 ENOG41069H0 dihydroorotase EC 3.5.2.3 F8267_RS11160 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) F8267_RS11165 ENOG4105EMD TRANSCRIPTIONal F8267_RS11170 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) F8267_RS11175 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase F8267_RS11190 ENOG4105F8D glycoside hydrolase family 4 F8267_RS11195 ENOG4105CK1 PTS System F8267_RS11200 ENOG4105CG3 alpha amylase, catalytic region F8267_RS11205 ENOG4105C5Y PTS System F8267_RS11210 ENOG4105D4X repressor F8267_RS11220 ENOG4105E2D ec 3.2.1.52 F8267_RS11225 ENOG4105KME endoribonuclease L-psp F8267_RS11230 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) F8267_RS11235 ENOG4105CXT aspartate transcarbamylase F8267_RS11245 ENOG4105XEP YhcH YjgK YiaL family protein F8267_RS11250 ENOG4105DBV ornithine carbamoyltransferase F8267_RS11255 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) F8267_RS11260 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase F8267_RS11265 ENOG4108MJ3 acetyltransferase F8267_RS11270 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) F8267_RS11275 ENOG4105MYG DNA polymerase iii, chi subunit F8267_RS11285 ENOG4108M8S permease YjgP YjgQ family protein F8267_RS11290 ENOG4108K5H permease YjgP YjgQ family protein F8267_RS11300 ENOG4105D7A ATP-binding protein F8267_RS11310 ENOG4105C26 Dehydrogenase F8267_RS11315 ENOG4105DH8 myo-inositol catabolism F8267_RS11320 ENOG4105CHC glucokinase (EC 2.7.1.2) F8267_RS11325 ENOG4105D7K pfkb domain protein F8267_RS11330 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) F8267_RS11340 ENOG4105F0H myo-inositol catabolism protein F8267_RS11345 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) F8267_RS11350 ENOG4107QNK )-transporter F8267_RS11360 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F8267_RS11365 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) F8267_RS11370 ENOG4105DRS transport system, permease F8267_RS11380 ENOG4105DQ4 alcohol dehydrogenase F8267_RS11385 ENOG4105CHH sulfate transporter F8267_RS11390 ENOG41077A9 carbonic anhydrase F8267_RS11405 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 F8267_RS11415 ENOG4108YUH F8267_RS11430 ENOG4107XZC Restriction modification system DNA (Specificity F8267_RS11435 ENOG4105CVR type I restriction-modification system F8267_RS11440 ENOG4107SCJ type I restriction enzyme EcoKI subunit R F8267_RS11470 ENOG4108IJF Heavy metal efflux pump, CzcA F8267_RS11475 ENOG4105EP1 Efflux transporter rnd family, mfp subunit F8267_RS11480 ENOG410624V efflux system protein F8267_RS11485 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F8267_RS11490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F8267_RS11495 ENOG4105GR3 Histidine kinase F8267_RS11500 ENOG4105EZE Cupin 4 family protein F8267_RS11530 ENOG4105CMI transporter F8267_RS11535 ENOG4105CJ1 ABC, transporter F8267_RS11540 ENOG4105D0S secretion protein (HlyD F8267_RS11545 ENOG4105BZU Histidine kinase F8267_RS11570 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) F8267_RS11575 ENOG4105KNY Microcompartments protein F8267_RS11580 ENOG4105F1A Pyruvate formate-lyase F8267_RS11585 ENOG4105C6N Formate acetyltransferase F8267_RS11600 ENOG4105C0A alcohol dehydrogenase F8267_RS11605 ENOG4105KNY Microcompartments protein F8267_RS11610 ENOG4105KNY Microcompartments protein F8267_RS11615 ENOG4105KNY Microcompartments protein F8267_RS11645 ENOG4105F3R pts system mannose fructose sorbose family iid F8267_RS11650 ENOG4105ETZ PTS System F8267_RS11655 ENOG4105DAS pts system F8267_RS11675 ENOG4105CUB amino acid F8267_RS11685 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F8267_RS11690 ENOG4106DIZ Domain of unknown function (DUF1127) F8267_RS11700 ENOG4105EFX secretion protein, HlyD family F8267_RS11715 ENOG4108P2H Inner membrane protein YjiG F8267_RS11730 ENOG4105CIZ coA-substrate-specific enzyme activase F8267_RS11735 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase F8267_RS11745 ENOG41083G8 Multidrug resistance protein MdtM F8267_RS11750 ENOG4106BRA Membrane F8267_RS11760 ENOG4105C26 Dehydrogenase F8267_RS11765 ENOG4105CKI cobalamin synthesis protein F8267_RS11770 ENOG4105VCD cytoplasmic protein F8267_RS11775 ENOG4105D22 carbon starvation protein F8267_RS11780 ENOG4105D5K Hemolysin activator protein F8267_RS11785 ENOG4105CKT filamentous hemagglutinin F8267_RS11795 ENOG4105CKT filamentous hemagglutinin F8267_RS11815 ENOG4107UWN reductase F8267_RS11820 ENOG4105EFA 4-hydroxyphenylacetate F8267_RS11825 ENOG4108NKV transcriptional regulator F8267_RS11835 ENOG4105CNV Aldolase F8267_RS11850 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase F8267_RS11855 ENOG4105C26 Dehydrogenase F8267_RS11865 ENOG4105ERH Fumarylacetoacetate hydrolase F8267_RS11875 ENOG4108V8F Transcriptional regulator, MarR family F8267_RS11880 ENOG4108I5G Major Facilitator superfamily F8267_RS11885 ENOG410617M Transcriptional regulator F8267_RS11890 ENOG4105CPQ Dehydrogenase F8267_RS11925 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 F8267_RS11930 ENOG4108RTU Aldolase F8267_RS11935 ENOG4105CHC glucokinase (EC 2.7.1.2) F8267_RS11940 ENOG4105XYF acetyltransferase F8267_RS11950 ENOG4107RES phosphoglycerol transferase I F8267_RS11955 ENOG4105RI1 glycoprotein receptor F8267_RS11960 ENOG4106CVF DNA replication protein F8267_RS11965 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) F8267_RS11975 ENOG4105DWK Membrane F8267_RS11980 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase F8267_RS11990 ENOG4108N8T regulatoR F8267_RS11995 ENOG4108T94 DNA-binding transcriptional activator BglJ F8267_RS12000 ENOG4108UIN ybak prolyl-trna synthetase associated region F8267_RS12005 ENOG4105CK1 PTS System F8267_RS12010 ENOG4108819 ferric iron reductase F8267_RS12015 ENOG4106TD9 Diguanylate cyclase F8267_RS12020 ENOG4105YBH Protein of unknown function (DUF1435) F8267_RS12045 ENOG4108WPU DNA polymerase III subunit psi F8267_RS12050 ENOG4105KEG ribosomal-protein-alanine acetyltransferase F8267_RS12055 ENOG4105PAD Hydrolase F8267_RS12065 ENOG4105K3G Periplasmic Protein F8267_RS12075 ENOG4108NRW Phospholipase, patatin family F8267_RS12080 ENOG4105EYA deoxyribonuclease F8267_RS12090 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) F8267_RS12105 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) F8267_RS12110 ENOG41062Z9 Membrane F8267_RS12115 ENOG4105EAC phosphoserine phosphatase F8267_RS12120 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F8267_RS12125 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase F8267_RS12130 ENOG4105C5H ABC transporter F8267_RS12135 ENOG4107SC1 transglycosylase F8267_RS12140 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) F8267_RS12150 ENOG4105CVJ phosphoglycerate mutase F8267_RS12155 ENOG4105UEI Transcriptional Regulator AraC Family F8267_RS12160 ENOG4108RH0 Crea protein F8267_RS12165 ENOG4105E3W Two component transcriptional regulator (Winged helix family F8267_RS12170 ENOG4105EB3 Histidine kinase F8267_RS12175 ENOG4105CT7 inner membrane cred family protein F8267_RS12180 ENOG41065U4 response regulator F8267_RS12185 ENOG410759A F8267_RS12190 ENOG4106FVC RNA methyltransferase F8267_RS12200 ENOG4105CFH Aspartokinase F8267_RS12205 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) F8267_RS12210 ENOG4105D98 threonine synthase F8267_RS12220 ENOG4105BZG amino acid carrier protein F8267_RS12225 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F8267_RS12230 ENOG4108RIR Molybdenum cofactor biosynthesis protein F8267_RS12235 ENOG4105CSH Transporter F8267_RS12240 ENOG4106HK8 GPR1 FUN34 yaaH family protein F8267_RS12245 ENOG4105CFG Acts as a chaperone (By similarity) F8267_RS12250 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F8267_RS12255 ENOG4108PTX LysR family Transcriptional regulator F8267_RS12285 ENOG4108PNB DNA-binding transcriptional regulator F8267_RS12290 ENOG4105HMV Fimbrial protein F8267_RS12295 ENOG4108AF8 Chaperone F8267_RS12300 ENOG4105CW0 outer membrane usher protein F8267_RS12305 ENOG4105MHR Fimbrial protein F8267_RS12320 ENOG4106PH7 chaperone F8267_RS12335 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) F8267_RS12340 ENOG41063Z6 transcriptional regulator, lysR family F8267_RS12355 ENOG4105DTN riboflavin biosynthesis protein ribF F8267_RS12365 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) F8267_RS12370 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase F8267_RS12375 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) F8267_RS12380 ENOG4105DU0 nucleoside hydrolase F8267_RS12385 ENOG4105F04 LysR family Transcriptional regulator F8267_RS12390 ENOG4105C7F AcnD-accessory protein PrpF F8267_RS12395 ENOG4107QPK )-transporter F8267_RS12400 ENOG4105C8P )-transporter F8267_RS12405 ENOG4107QM5 aconitate hydratase F8267_RS12410 ENOG4105EXG Transcriptional regulator F8267_RS12415 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F8267_RS12420 ENOG4106YYS transcriptional regulatory protein F8267_RS12425 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F8267_RS12430 ENOG4105D9Q decarboxylase (Beta subunit) F8267_RS12435 ENOG4107QSA Oxaloacetate decarboxylase F8267_RS12445 ENOG4105D2K citrate carrier protein F8267_RS12450 ENOG4105DUA (citrate (pro-3S)-lyase ligase F8267_RS12460 ENOG4105CI0 Citrate lyase F8267_RS12465 ENOG4105CHY citrate lyase, alpha F8267_RS12470 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase F8267_RS12480 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain F8267_RS12485 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain F8267_RS12490 ENOG4105M5B (LipO)protein F8267_RS12510 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) F8267_RS12515 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F8267_RS12530 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) F8267_RS12540 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) F8267_RS12545 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) F8267_RS12550 ENOG4106YYS transcriptional regulatory protein F8267_RS12555 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F8267_RS12560 ENOG4105D2K citrate carrier protein F8267_RS12570 ENOG4105D3G Pseudouridine synthase F8267_RS12575 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) F8267_RS12580 ENOG4105CQ2 DNA polymerase F8267_RS12585 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase F8267_RS12590 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) F8267_RS12600 ENOG41063TF transcriptional regulator (AraC F8267_RS12605 ENOG4108KF1 Membrane F8267_RS12615 ENOG4106SMU thiamine transporter membrane protein F8267_RS12635 ENOG4105S8Q sugar efflux transporter F8267_RS12640 ENOG4105DJB Major Facilitator Superfamily F8267_RS12645 ENOG4105DND Transcriptional regulator F8267_RS12650 ENOG4105FF2 Type I DHQase F8267_RS12655 ENOG4105EMV Major Facilitator F8267_RS12675 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F8267_RS12685 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F8267_RS12695 ENOG41064T2 transcriptional regulator, lysR family F8267_RS12700 ENOG4105C7K acetolactate synthase F8267_RS12705 ENOG4108ZP8 Acetolactate synthase small subunit F8267_RS12710 ENOG4107B7Y DNA-binding transcriptional regulator FruR F8267_RS12725 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F8267_RS12730 ENOG4105CJN penicillin-binding protein F8267_RS12735 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F8267_RS12740 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) F8267_RS12745 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) F8267_RS12755 ENOG4105CNI cell division protein FtsW F8267_RS12770 ENOG4105CPF Cell wall formation (By similarity) F8267_RS12775 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) F8267_RS12780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F8267_RS12785 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F8267_RS12790 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F8267_RS12795 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) F8267_RS12800 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving F8267_RS12805 ENOG4105M6F mutator MutT protein F8267_RS12820 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F8267_RS12830 ENOG4105D7Q type ii secretion system F8267_RS12835 ENOG4107QHF type ii secretion system protein e F8267_RS12840 ENOG4108ZUW Major pilin subunit F8267_RS12845 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F8267_RS12855 ENOG4106A72 regulatory protein AmpE F8267_RS12860 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) F8267_RS12865 ENOG4105CT4 transporter F8267_RS12870 ENOG4105C85 amino acid F8267_RS12875 ENOG41073TP transcriptional regulator F8267_RS12880 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F8267_RS12885 ENOG4107QSN dihydrolipoamide acetyltransferase F8267_RS12890 ENOG4107QN2 dihydrolipoyl dehydrogenase F8267_RS12905 ENOG4108NST exported protein F8267_RS12910 ENOG4107QIJ Aconitate hydratase 2 F8267_RS12920 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) F8267_RS12930 ENOG4108V1T peptidylprolyl cis-trans isomerase F8267_RS12940 ENOG4108ZRK uncharacterized protein yacC F8267_RS12945 ENOG4105E3B Multicopper oxidase F8267_RS12950 ENOG4105DZG Dehydrogenase F8267_RS12955 ENOG4108UGV hypoxanthine phosphoribosyltransferase F8267_RS12960 ENOG41077A9 carbonic anhydrase F8267_RS12965 ENOG4105DA5 (ABC) transporter F8267_RS12970 ENOG4105E3A (ABC) transporter F8267_RS12975 ENOG4108YTN IIa component F8267_RS12980 ENOG4107BJW polysaccharide deacetylase F8267_RS12985 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) F8267_RS13000 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F8267_RS13005 ENOG4105DJ0 Poly(A) Polymerase F8267_RS13015 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters F8267_RS13020 ENOG4105PW4 Sugar fermentation stimulation protein homolog F8267_RS13025 ENOG4107XID 2'-5' rna ligase F8267_RS13030 ENOG4105CQ7 ATP-dependent helicase F8267_RS13035 ENOG4105BZ4 penicillin-binding protein F8267_RS13040 ENOG4105E0K tonB-dependent siderophore receptor F8267_RS13045 ENOG4105E0A ABC, transporter F8267_RS13050 ENOG4105J76 Periplasmic binding protein F8267_RS13055 ENOG4105S6R Iron-hydroxamate transporter permease subunit F8267_RS13065 ENOG4105CMQ Chloride channel F8267_RS13075 ENOG4105EN6 Membrane F8267_RS13080 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) F8267_RS13085 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F8267_RS13090 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein F8267_RS13095 ENOG4105C0H protease F8267_RS13100 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR F8267_RS13110 ENOG4108T8E UPF0325 protein F8267_RS13115 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) F8267_RS13120 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) F8267_RS13125 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F8267_RS13135 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) F8267_RS13140 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F8267_RS13150 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F8267_RS13160 ENOG4105KNE Phosphatidate cytidylyltransferase F8267_RS13165 ENOG4105DZP Membrane-associated zinc metalloprotease F8267_RS13175 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) F8267_RS13180 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F8267_RS13185 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) F8267_RS13195 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F8267_RS13200 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F8267_RS13205 ENOG4105C0B DNA polymerase III (alpha subunit) F8267_RS13210 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) F8267_RS13220 ENOG4105CXN decarboxylase F8267_RS13225 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase F8267_RS13230 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F8267_RS13235 ENOG4105M1T rho-binding antiterminator F8267_RS13240 ENOG4105W1I UPF0253 protein F8267_RS13245 ENOG4108VWS Yaeq family F8267_RS13250 ENOG4108YZN class I peptide chain release factor F8267_RS13255 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion F8267_RS13265 ENOG4108R96 Methyltransferase, YaeB family F8267_RS13270 ENOG4108R8X outer membrane lipoprotein F8267_RS13275 ENOG4105D01 (LipO)protein F8267_RS13280 ENOG4108UMI ABC transporter, permease F8267_RS13285 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F8267_RS13290 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase F8267_RS13325 ENOG4105CV8 reductase F8267_RS13330 ENOG4105HEI LysR family (Transcriptional regulator F8267_RS13335 ENOG4105F27 Major Facilitator F8267_RS13345 ENOG4105F2W methyltransferase F8267_RS13350 ENOG4105E9H Lytic Murein transglycosylase F8267_RS13355 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F8267_RS13360 ENOG4105D1A Methyltransferase F8267_RS13365 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F8267_RS13370 ENOG4107RZZ dna polymerase iii epsilon subunit F8267_RS13380 ENOG41090KR LysR family transcriptional Regulator F8267_RS13385 ENOG4108VP3 Lysine exporter protein (LysE YggA) F8267_RS13390 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F8267_RS13395 ENOG4107QPN acyl-Coa dehydrogenase F8267_RS13405 ENOG4105E7A Glutamine amidotransferase F8267_RS13410 ENOG4105F7V ErfK ybiS ycfS ynhG family protein F8267_RS13425 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F8267_RS13430 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F8267_RS13435 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) F8267_RS13440 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) F8267_RS13455 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F8267_RS13460 ENOG4108HYG acetyltransferase F8267_RS13465 ENOG4105CIN aminoacyl-histidine dipeptidase F8267_RS13470 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) F8267_RS13475 ENOG4105V1F Fermentation respiration switch protein F8267_RS13480 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) F8267_RS13485 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB F8267_RS13500 ENOG4107RA4 Glycosyl transferase (Group 1 F8267_RS13505 ENOG4105CG5 Glycosyl transferase (Group 1 F8267_RS13510 ENOG4106WTF Glycosyl transferase, family 2 F8267_RS13540 ENOG4105D3Q Sugar transferase F8267_RS13555 ENOG4105EWI Short-chain dehydrogenase reductase Sdr F8267_RS13565 ENOG4107RSM transcriptional regulator F8267_RS13575 ENOG4108PVQ transcriptional regulator F8267_RS13580 ENOG4105C85 amino acid F8267_RS13585 ENOG4108JPW Aminotransferase F8267_RS13590 ENOG4105C26 Dehydrogenase F8267_RS13595 ENOG4105D5U fad dependent oxidoreductase F8267_RS13615 ENOG4105CW0 outer membrane usher protein F8267_RS13620 ENOG4108VCD Chaperone F8267_RS13650 ENOG4107RRE RNA-directed DNA polymerase F8267_RS13690 ENOG4105FCK Membrane F8267_RS13695 ENOG4108QBX (LipO)protein F8267_RS13715 ENOG4105S7S phosphonate abc transporter F8267_RS13725 ENOG4105EHI Phosphonate ABC transporter, periplasmic F8267_RS13745 ENOG4108NN8 Fimbrial protein F8267_RS13750 ENOG4108N3D putative enzyme F8267_RS13755 ENOG4106PYX Receptor F8267_RS13770 ENOG4105DJB Major Facilitator Superfamily F8267_RS13775 ENOG410811B TRANSCRIPTIONal F8267_RS13780 ENOG4105DRP amino acid AbC transporter F8267_RS13785 ENOG4105E5Q amino acid AbC transporter F8267_RS13795 ENOG4105CT1 (ABC) transporter F8267_RS13800 ENOG4108IQI permease F8267_RS13805 ENOG4107QK5 Homocysteine s-methyltransferase F8267_RS13810 ENOG4106FTQ Taurine ABC transporter, periplasmic F8267_RS13815 ENOG4108ETV ABC transporter F8267_RS13820 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F8267_RS13825 ENOG4105E2B Taurine dioxygenase F8267_RS13840 ENOG4108UK5 Transposase F8267_RS13845 ENOG4105D52 delta-aminolevulinic acid dehydratase F8267_RS13850 ENOG4107R6D beta-lactam binding protein AmpH F8267_RS13860 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 F8267_RS13865 ENOG4107QS8 (LipO)protein F8267_RS13870 ENOG4105FR5 inner membrane protein YaiY F8267_RS13875 ENOG4105UNH Membrane F8267_RS13880 ENOG4105CPF Cell wall formation (By similarity) F8267_RS13895 ENOG4105G6Z alkaline phosphatase F8267_RS13900 ENOG4105VIF phosphate starvation-inducible protein F8267_RS13905 ENOG4105II7 pyrroline-5-carboxylate reductase F8267_RS13910 ENOG4108UPT UPF0178 protein F8267_RS13915 ENOG4105G4C Periplasmic ligand-binding sensor protein F8267_RS13920 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F8267_RS13925 ENOG4105SS3 F8267_RS13930 ENOG4105HBA AroM protein F8267_RS13935 ENOG4105NBK UPF0345 protein F8267_RS13940 ENOG4105DH7 May be involved in recombination (By similarity) F8267_RS13945 ENOG4105DKQ ROK family F8267_RS13950 ENOG4105EYH Exonuclease F8267_RS13955 ENOG4107RH8 nuclease SbcCD subunit D F8267_RS13960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F8267_RS13965 ENOG4105BZU Histidine kinase F8267_RS13970 ENOG4105CWM branched-chain amino acid transport system II carrier protein F8267_RS13975 ENOG4105C85 amino acid F8267_RS13980 ENOG4107R28 alpha amylase, catalytic region F8267_RS13985 ENOG4105EQ1 Transcriptional regulator F8267_RS13990 ENOG4105CHJ isochorismatase hydrolase F8267_RS14000 ENOG4105EFZ amidohydrolase F8267_RS14005 ENOG4105D3R alkyl hydroperoxide reductase F8267_RS14020 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) F8267_RS14025 ENOG4105VIE preprotein translocase, subunit YajC F8267_RS14035 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F8267_RS14050 ENOG4105DRB nucleoside-specific channel-forming protein F8267_RS14055 ENOG4108KIC (LipO)protein F8267_RS14060 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) F8267_RS14065 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F8267_RS14070 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) F8267_RS14080 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) F8267_RS14085 ENOG4108ZAI phosphatidylglycerophosphatase a F8267_RS14090 ENOG4105CPC Aldo Keto reductase F8267_RS14095 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) F8267_RS14100 ENOG4105CTB Polyprenyl synthetase F8267_RS14105 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) F8267_RS14110 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) F8267_RS14120 ENOG4107S0N DJ-1 family F8267_RS14125 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) F8267_RS14130 ENOG4108VPT UPF0234 protein F8267_RS14140 ENOG4105D5K Hemolysin activator protein F8267_RS14145 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) F8267_RS14155 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) F8267_RS14160 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F8267_RS14170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F8267_RS14185 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F8267_RS14195 ENOG4105CRP Part of the ABC transporter FtsEX involved in F8267_RS14215 ENOG4108T85 Membrane F8267_RS14225 ENOG4107RDB Major Facilitator F8267_RS14235 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) F8267_RS14240 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) F8267_RS14245 ENOG4105CCU oxidase (Subunit III) F8267_RS14250 ENOG4105BZ9 Cytochrome C oxidase, subunit I F8267_RS14255 ENOG4105E2S oxidase) subunit II F8267_RS14260 ENOG4105EYM Major Facilitator superfamily F8267_RS14265 ENOG4105IEY (LipO)protein F8267_RS14270 ENOG4105M85 Bola protein F8267_RS14290 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) F8267_RS14295 ENOG4105K70 DNA-binding protein F8267_RS14300 ENOG4105EIN peptidylprolyl cis-trans isomerase F8267_RS14305 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein F8267_RS14310 ENOG4108TGP Thioesterase superfamily protein F8267_RS14320 ENOG4108NFA extracellular solute-binding protein F8267_RS14335 ENOG4108XM1 transcriptional regulator AsnC family F8267_RS14340 ENOG4105BZ1 (ABC) transporter F8267_RS14345 ENOG4105BZ1 (ABC) transporter F8267_RS14350 ENOG4108YZA Nitrogen regulatory protein pii F8267_RS14355 ENOG4105BZU Histidine kinase F8267_RS14360 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) F8267_RS14365 ENOG4106NZI LysR family Transcriptional regulator F8267_RS14370 ENOG4105C29 acyl-CoA thioesterase F8267_RS14375 ENOG4108MNP Glycoprotein polysaccharide metabolism F8267_RS14380 ENOG41080UX Methyltransferase F8267_RS14410 ENOG4108VW9 Membrane F8267_RS14415 ENOG4105KCV RNA signal recognition particle 4.5S RNA F8267_RS14420 ENOG41066DG (EAL) domain protein F8267_RS14430 ENOG4105YK5 50S ribosomal protein L36 F8267_RS14445 ENOG4105GSJ Inner membrane protein ylaC F8267_RS14450 ENOG4108UW5 maltose o-acetyltransferase F8267_RS14460 ENOG4108UKR Biofilm formation regulator YbaJ F8267_RS14465 ENOG4105BZS acriflavin resistance protein F8267_RS14470 ENOG4105C1P efflux transporter, rnd family, mfp subunit F8267_RS14475 ENOG4107XI7 Tetr family transcriptional regulator F8267_RS14480 ENOG4105EGS Mechanosensitive ion channel F8267_RS14485 ENOG4106428 Protein of unknown function (DUF2496) F8267_RS14490 ENOG4108URS primosomal replication protein n'' F8267_RS14495 ENOG4105WD1 Membrane F8267_RS14505 ENOG4107QMP dna polymerase iii subunits gamma and tau F8267_RS14515 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) F8267_RS14520 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) F8267_RS14525 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) F8267_RS14535 ENOG4107RE1 Inosine-guanosine kinase F8267_RS14540 ENOG4105CKD glutathione-regulated potassium-efflux system protein F8267_RS14545 ENOG4105EU0 Major facilitator Superfamily F8267_RS14550 ENOG4105CGH 5'-nucleotidase F8267_RS14555 ENOG4108Z66 YbaK ebsC protein F8267_RS14560 ENOG4105MBR gumn family F8267_RS14565 ENOG4105C59 p-type ATPase F8267_RS14570 ENOG4108Z6Z Transcriptional regulator F8267_RS14575 ENOG4105G5H Membrane F8267_RS14580 ENOG4107QX8 SPFH domain, Band 7 family protein F8267_RS14585 ENOG41083J0 (ABC) transporter F8267_RS14590 ENOG4105C4B ABC transporter, permease F8267_RS14595 ENOG4107QR8 Thioredoxin F8267_RS14600 ENOG4105E1F short-chain dehydrogenase reductase F8267_RS14605 ENOG4108UJV acyl-CoA thioesterase i F8267_RS14610 ENOG4108I0Y (ABC) transporter F8267_RS14615 ENOG4105CV6 ABC transporter, permease F8267_RS14630 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F8267_RS14635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F8267_RS14640 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) F8267_RS14645 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) F8267_RS14650 ENOG4105C8N cysteinyl-tRNA synthetase F8267_RS14655 ENOG4105WQ3 Rna-binding protein F8267_RS14660 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F8267_RS14675 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) F8267_RS14685 ENOG4105CSH Transporter F8267_RS14695 ENOG4105F04 LysR family Transcriptional regulator F8267_RS14710 ENOG4105D1S lipid A biosynthesis F8267_RS14720 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F8267_RS14725 ENOG4108M3R transcriptional activator CadC F8267_RS14730 ENOG4105D5Q Arginine ornithine antiporter F8267_RS14735 ENOG4105CXN decarboxylase F8267_RS14740 ENOG4105DUX Transporter F8267_RS14745 ENOG4105CRK lysyL-tRNA synthetase F8267_RS14750 ENOG4105DZC cytosine deaminase F8267_RS14755 ENOG4105C5B carbamate kinase F8267_RS14760 ENOG4107REC cytoplasmic protein F8267_RS14765 ENOG4107R1Q Membrane protein FdrA F8267_RS14770 ENOG4105N16 Protein of unknown function (DUF2877) F8267_RS14775 ENOG4107SNB ankyrin repeat protein YahD F8267_RS14780 ENOG4105SZ2 membrAne F8267_RS14785 ENOG4108NUU Transcriptional regulator F8267_RS14795 ENOG4105KK7 inner membrane protein YiaW F8267_RS14800 ENOG4105EFX secretion protein, HlyD family F8267_RS14820 ENOG4105CH2 amidohydrolase F8267_RS14825 ENOG4105E89 ABC transporter F8267_RS14830 ENOG4105CPC Aldo Keto reductase F8267_RS14845 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) F8267_RS14855 ENOG4108UAJ Transcriptional regulator F8267_RS14865 ENOG4105DGU Histone deacetylase F8267_RS14875 ENOG4105CUB amino acid F8267_RS14885 ENOG4105CJP fad dependent oxidoreductase F8267_RS14890 ENOG4105C26 Dehydrogenase F8267_RS14895 ENOG4105CEP NADH dehydrogenase F8267_RS14900 ENOG4108NS2 receptor F8267_RS14910 ENOG4105C85 amino acid F8267_RS14915 ENOG4105CUY Mechanosensitive ion channel F8267_RS14935 ENOG4108RCM Nitroreductase F8267_RS14940 ENOG4105MSB protein, conserved in bacteria F8267_RS14955 ENOG4105HFT AraC family transcriptional regulator F8267_RS14960 ENOG4105WQ6 Membrane F8267_RS14970 ENOG4108T58 Mg2 transport protein CorA F8267_RS14980 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) F8267_RS14990 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) F8267_RS14995 ENOG4105C94 Transporter F8267_RS15005 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) F8267_RS15025 ENOG4105CNN ABC, transporter F8267_RS15030 ENOG4105C2J ABC transporter F8267_RS15040 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F8267_RS15045 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) F8267_RS15050 ENOG4105DKT Transcriptional regulator F8267_RS15055 ENOG4108HHA Transketolase F8267_RS15060 ENOG4108IUS Transketolase F8267_RS15065 ENOG4107RNH Outer membrane receptor FepA F8267_RS15070 ENOG4105E93 esterase F8267_RS15075 ENOG41085A6 mbth domain-containing protein F8267_RS15080 ENOG4105C0W non-ribosomal peptide synthetase F8267_RS15085 ENOG4105E0A ABC, transporter F8267_RS15090 ENOG4105TVJ transport system, permease F8267_RS15095 ENOG4105DQ5 transport system permease protein F8267_RS15100 ENOG4105E8G Major facilitator Superfamily F8267_RS15110 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein F8267_RS15115 ENOG4105E4F Isochorismate synthase F8267_RS15120 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F8267_RS15125 ENOG4105WQI isochorismatase F8267_RS15130 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F8267_RS15135 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) F8267_RS15140 ENOG4105D22 carbon starvation protein F8267_RS15145 ENOG4105VCD cytoplasmic protein F8267_RS15160 ENOG4105CHR reductase F8267_RS15165 ENOG4105C2J ABC transporter F8267_RS15170 ENOG4105CNN ABC, transporter F8267_RS15180 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) F8267_RS15195 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) F8267_RS15205 ENOG4105CHM Aminotransferase F8267_RS15210 ENOG4105GTN ParB Domain Protein Nuclease F8267_RS15215 ENOG4105BZV Phosphoadenosine phosphosulfate reductase F8267_RS15220 ENOG4105DQS Transcriptional regulator F8267_RS15225 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase F8267_RS15230 ENOG4105D3R alkyl hydroperoxide reductase F8267_RS15235 ENOG4108JU3 Alkyl hydroperoxide reductase F8267_RS15240 ENOG4108U51 Universal stress protein F8267_RS15245 ENOG4105NXH GreA GreB family elongation factor F8267_RS15250 ENOG4105KTS ribonuclease F8267_RS15255 ENOG4105CEE C4-dicarboxylate transporter F8267_RS15260 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) F8267_RS15280 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) F8267_RS15285 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) F8267_RS15290 ENOG41064T2 transcriptional regulator, lysR family F8267_RS15295 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) F8267_RS15300 ENOG4108Z43 UPF0250 protein F8267_RS15305 ENOG4105DZ1 carboxypeptidase F8267_RS15310 ENOG4105K6T rare lipoprotein A F8267_RS15315 ENOG4105CNI cell division protein FtsW F8267_RS15320 ENOG4105CJN penicillin-binding protein F8267_RS15325 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) F8267_RS15330 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) F8267_RS15335 ENOG4108TGR phosphatase F8267_RS15340 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) F8267_RS15345 ENOG4105DJF DNA polymerase III, delta' subunit F8267_RS15355 ENOG4105C8T Leucyl-tRNA synthetase F8267_RS15360 ENOG4107PAI alpha helical protein F8267_RS15370 ENOG4105D5K Hemolysin activator protein F8267_RS15375 ENOG4105CDA abc transporter atp-binding protein F8267_RS15380 ENOG4105DRP amino acid AbC transporter F8267_RS15385 ENOG4105EAD ABC transporter F8267_RS15390 ENOG4107RP9 extracellular solute-binding protein, family 3 F8267_RS15395 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) F8267_RS15400 ENOG4108JU5 Magnesium and cobalt efflux protein F8267_RS15405 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) F8267_RS15410 ENOG4105C9A Phoh family F8267_RS15420 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F8267_RS15460 ENOG4105CAQ asparagine synthetase F8267_RS15465 ENOG4105D4U had-superfamily hydrolase, subfamily iia F8267_RS15470 ENOG4105E2R ROK family F8267_RS15475 ENOG4105CE4 GlcNAc 6-P deacetylase F8267_RS15485 ENOG4105CI1 PTS System F8267_RS15490 ENOG4105CX6 glutaminyL-tRNA synthetase F8267_RS15505 ENOG4105GX6 (LipO)protein F8267_RS15520 ENOG4107EFR Flavocytochrome c F8267_RS15525 ENOG4106P55 Transcriptional regulator F8267_RS15530 ENOG41090R7 Ferric uptake F8267_RS15535 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) F8267_RS15540 ENOG4105NNH LexA regulated protein F8267_RS15545 ENOG4105EV9 Alpha Beta Hydrolase F8267_RS15550 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) F8267_RS15555 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 F8267_RS15560 ENOG4105EEX Two component transcriptional regulator (Winged helix family F8267_RS15565 ENOG4105C08 Histidine kinase F8267_RS15575 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F8267_RS15590 ENOG4105XIQ Protein of unknown function (DUF2517) F8267_RS15595 ENOG4105CVP deoxyribo-dipyrimidine photolyase F8267_RS15605 ENOG4107QNR UPF0135 protein F8267_RS15610 ENOG4105P4J Allophanate hydrolase, subunit 1 F8267_RS15615 ENOG4107R7A Allophanate hydrolase subunit 2 F8267_RS15620 ENOG4105E7W lamb ycsf family protein F8267_RS15640 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) F8267_RS15645 ENOG4105BZN citrate synthase F8267_RS15650 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit F8267_RS15655 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein F8267_RS15660 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) F8267_RS15665 ENOG4105E33 succinate dehydrogenase F8267_RS15670 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 F8267_RS15675 ENOG4105C7S Dehydrogenase F8267_RS15680 ENOG4105CMV Succinyl-CoA synthetase subunit beta F8267_RS15685 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F8267_RS15690 ENOG4105C4M (Ubiquinol oxidase) subunit I F8267_RS15695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F8267_RS15705 ENOG4105KJB cyd operon protein YbgE F8267_RS15710 ENOG4107YD3 Thioesterase F8267_RS15715 ENOG4105E02 MotA TolQ exbB proton channel F8267_RS15725 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA F8267_RS15735 ENOG4105KCK Peptidoglycan-associated lipoprotein F8267_RS15740 ENOG4105UFD tol-pal system protein YbgF F8267_RS15780 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) F8267_RS15785 ENOG4106Z1T Nicotinamide Mononucleotide Transporter F8267_RS15790 ENOG4105PGM cation diffusion facilitator family transporter F8267_RS15795 ENOG4105JND homeobox protein F8267_RS15800 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F8267_RS15805 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F8267_RS15810 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) F8267_RS15815 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) F8267_RS15820 ENOG4105F0Z galactose-1-phosphate uridylyltransferase F8267_RS15825 ENOG4105CMR udp-glucose 4-epimerase F8267_RS15830 ENOG4105DKW ABC transporter F8267_RS15835 ENOG4105F4R Transcriptional regulator mode F8267_RS15845 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F8267_RS15850 ENOG4105E0C molybdate abc transporter F8267_RS15860 ENOG4108K4B hydrolase F8267_RS15880 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component F8267_RS15885 ENOG4105BZU Histidine kinase F8267_RS15890 ENOG4108XDN Transcriptional regulator F8267_RS15915 ENOG4105EMN RNA polymerase sigma factor F8267_RS15925 ENOG4105NBR Pectinesterase F8267_RS15955 ENOG4105C84 Histidine ammonia-lyase F8267_RS15960 ENOG4105C85 amino acid F8267_RS15965 ENOG4108V1U phospholipid-binding protein F8267_RS15970 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F8267_RS15985 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F8267_RS15990 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F8267_RS16000 ENOG4105ECM Sensor protein basS pmrB F8267_RS16005 ENOG4105XJC Two component transcriptional regulator (Winged helix family F8267_RS16010 ENOG4105DIJ Phosphoethanolamine transferase F8267_RS16015 ENOG4105CHW UPF0052 protein F8267_RS16025 ENOG4108RIR Molybdenum cofactor biosynthesis protein F8267_RS16035 ENOG4105M00 molybdopterin converting factor, subunit 1 F8267_RS16040 ENOG4108ZAF Molybdopterin F8267_RS16045 ENOG4105HFZ Membrane F8267_RS16050 ENOG4107UXM Membrane F8267_RS16055 ENOG4105DZQ phospholipase D Transphosphatidylase F8267_RS16060 ENOG4105X23 Endonuclease Exonuclease phosphatase F8267_RS16065 ENOG4105I9U inner membrane protein ybhQ F8267_RS16070 ENOG4107QWP ABC-2 type transporter F8267_RS16075 ENOG4107QWP ABC-2 type transporter F8267_RS16080 ENOG4105CJ1 ABC, transporter F8267_RS16085 ENOG4105D0S secretion protein (HlyD F8267_RS16090 ENOG4107MVR Transcriptional regulator F8267_RS16095 ENOG4105C1J atp-dependent rna helicase F8267_RS16105 ENOG4105DVT helicase F8267_RS16110 ENOG4108MTB glycosyl transferase family F8267_RS16115 ENOG4105VR4 UPF0379 protein ybiJ F8267_RS16120 ENOG4105KSC Transcriptional regulator, TraR DksA family F8267_RS16125 ENOG4105ZY9 UPF0379 protein ybiM F8267_RS16130 ENOG4105EW6 flavin reductase domain protein, FMN-binding F8267_RS16135 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) F8267_RS16140 ENOG4105D8X mechanosensitive ion channel F8267_RS16145 ENOG4105CDA abc transporter atp-binding protein F8267_RS16150 ENOG4105E5Q amino acid AbC transporter F8267_RS16155 ENOG4107R0W ABC transporter F8267_RS16160 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction F8267_RS16170 ENOG4108T1M outer membrane protein x F8267_RS16175 ENOG4108I6E Sulfatase F8267_RS16185 ENOG4105KST dependent repressor F8267_RS16190 ENOG4105F4P )-transporter F8267_RS16195 ENOG4105CPC Aldo Keto reductase F8267_RS16200 ENOG4105CS2 ec 3.2.1.21 F8267_RS16205 ENOG4108TZY GntR Family Transcriptional Regulator F8267_RS16210 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F8267_RS16220 ENOG4105C5H ABC transporter F8267_RS16230 ENOG4105DPW Major facilitator superfamily MFS_1 F8267_RS16235 ENOG4105ETE Transcriptional regulator (LacI family F8267_RS16240 ENOG41072TH Protein of unknown function (DUF1479) F8267_RS16245 ENOG4108HCJ Hydrolase F8267_RS16255 ENOG4105F1A Pyruvate formate-lyase F8267_RS16260 ENOG4105D06 uba thif-type nad fad binding protein F8267_RS16265 ENOG4105CVM Molybdenum cofactor synthesis domain protein F8267_RS16270 ENOG4105D44 asparaginase F8267_RS16275 ENOG4108JQ6 ABC transporter F8267_RS16280 ENOG4105DEF Extracellular solute-binding protein, family 5 F8267_RS16285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F8267_RS16300 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway F8267_RS16305 ENOG4105D8V Glucose sorbosone dehydrogenase F8267_RS16310 ENOG4108TGY Glutathione S-transferase F8267_RS16315 ENOG4105DZ1 carboxypeptidase F8267_RS16320 ENOG4107FB0 transcriptional regulator DeoR family F8267_RS16325 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F8267_RS16330 ENOG4107QF7 multi-drug F8267_RS16335 ENOG4108HCJ Hydrolase F8267_RS16340 ENOG4106UW1 Major Facilitator superfamily F8267_RS16345 ENOG4108RFG Tetr family transcriptional regulator F8267_RS16375 ENOG4105GWF inner membrane protein YbjM F8267_RS16380 ENOG41090BQ Glutaredoxin F8267_RS16385 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress F8267_RS16390 ENOG4108DBC nitroreductase F8267_RS16400 ENOG4108RMJ sensory transduction regulator F8267_RS16405 ENOG4107RUE extracellular solute-binding protein family 1 F8267_RS16410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F8267_RS16415 ENOG4105F38 ABC transporter, permease F8267_RS16420 ENOG4105D38 putrescine abc transporter F8267_RS16425 ENOG4105RBQ inner membrane protein ybjO F8267_RS16430 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) F8267_RS16435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F8267_RS16440 ENOG4105ES5 Histidine kinase F8267_RS16445 ENOG4106TNF Periplasmic binding protein F8267_RS16450 ENOG4105DMR ABC, transporter F8267_RS16455 ENOG4105GBT ABC transporter F8267_RS16460 ENOG4106PMH Extracellular solute-binding protein family 3 F8267_RS16465 ENOG4105E5Z arginine transporter ATP-binding subunit F8267_RS16470 ENOG41064MM (LipO)protein F8267_RS16475 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation F8267_RS16480 ENOG4105TDT uncharacterized protein yahO F8267_RS16490 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F8267_RS16495 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase F8267_RS16500 ENOG4105CGD Nad-dependent epimerase dehydratase F8267_RS16505 ENOG4105C5W Aldolase F8267_RS16510 ENOG4105C7K acetolactate synthase F8267_RS16520 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F8267_RS16530 ENOG4105DWU Membrane F8267_RS16535 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F8267_RS16540 ENOG4105CPB ATP-dependent endonuclease of the OLD family F8267_RS16545 ENOG4108MJ5 VirK protein F8267_RS16550 ENOG4105DJY efflux transporter, rnd family, mfp subunit F8267_RS16560 ENOG4105VEQ Cold shock protein F8267_RS16565 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) F8267_RS16570 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F8267_RS16580 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) F8267_RS16585 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) F8267_RS16590 ENOG4108JJ8 (ABC) transporter F8267_RS16595 ENOG4108JJ9 ABC, transporter F8267_RS16600 ENOG4105C3M thioredoxin reductase F8267_RS16605 ENOG4105EW9 transcriptional regulator AsnC family F8267_RS16610 ENOG4105CNU cell division protein FtsK F8267_RS16620 ENOG4105D1H recombination factor protein RarA F8267_RS16625 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) F8267_RS16630 ENOG4107QY8 reductase F8267_RS16635 ENOG4105QAX Iron-sulfur F8267_RS16640 ENOG4107KGK dmso reductase anchor subunit F8267_RS16645 ENOG4108ISG Major Facilitator F8267_RS16650 ENOG4105F1A Pyruvate formate-lyase F8267_RS16655 ENOG4105C6N Formate acetyltransferase F8267_RS16660 ENOG4105TMB Formate nitrite transporter F8267_RS16665 ENOG4105DDY UPF0142 protein ycaO F8267_RS16675 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) F8267_RS16685 ENOG4105CAT Cytidine monophosphate kinase F8267_RS16690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) F8267_RS16700 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 F8267_RS16705 ENOG4105BZ1 (ABC) transporter F8267_RS16710 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) F8267_RS16715 ENOG4105T0Z Conserved Protein F8267_RS16720 ENOG4105W49 UPF0434 protein F8267_RS16725 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) F8267_RS16730 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups F8267_RS16735 ENOG4107S90 membrAne F8267_RS16740 ENOG4106371 Methyltransferase F8267_RS16745 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) F8267_RS16750 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) F8267_RS16760 ENOG4105DIT ErfK YbiS YcfS YnhG family protein F8267_RS16765 ENOG4105EAQ (twin-arginine translocation) pathway signal F8267_RS16770 ENOG4105C5X domain protein F8267_RS16775 ENOG4105CGF Aromatic amino acid aminotransferase F8267_RS16780 ENOG4105ZIT Porin Gram-negative type F8267_RS16785 ENOG4105C5S asparaginyl-tRNA synthetase F8267_RS16790 ENOG4107RH7 Nicotinate phosphoribosyltransferase F8267_RS16795 ENOG4105CD8 aminopeptidase N F8267_RS16805 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F8267_RS16810 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F8267_RS16815 ENOG4105GVF (ABC) transporter F8267_RS16820 ENOG4108UZX fmn reductase F8267_RS16830 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) F8267_RS16835 ENOG4105QVC MOSC domain-containing protein F8267_RS16845 ENOG4105C5H ABC transporter F8267_RS16850 ENOG4105F1S paraquat-inducible protein a F8267_RS16855 ENOG4105DY2 Paraquat-inducible protein b F8267_RS16860 ENOG4108Q2G (LipO)protein F8267_RS16865 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) F8267_RS16875 ENOG4105DAN ATP-dependent protease F8267_RS16880 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) F8267_RS16885 ENOG4105UYK outer membrane protein a F8267_RS16890 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) F8267_RS16895 ENOG4108RZ1 DNA transformation protein F8267_RS16900 ENOG4105EM2 membrane F8267_RS16905 ENOG410901E Membrane F8267_RS16910 ENOG41088T4 Helicase IV F8267_RS16920 ENOG4105K4P CoA-binding domain protein F8267_RS16935 ENOG4108JJA ABC, transporter F8267_RS16945 ENOG4107STW synthase F8267_RS16955 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) F8267_RS16965 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 F8267_RS16975 ENOG4108MN8 Membrane F8267_RS16980 ENOG4107QSI ABC, transporter F8267_RS16990 ENOG4105HEI LysR family (Transcriptional regulator F8267_RS17005 ENOG4105DND Transcriptional regulator F8267_RS17010 ENOG4107B2H carbonic anhydrase F8267_RS17015 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) F8267_RS17020 ENOG4105WBN Transcriptional regulator (LacI family F8267_RS17025 ENOG4108HKT sucrose-6-phosphate hydrolase F8267_RS17035 ENOG4105D7K pfkb domain protein F8267_RS17040 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) F8267_RS17050 ENOG4107RD7 Flagellar Motor Protein, MotA F8267_RS17055 ENOG4105ER2 Ompa motb domain protein F8267_RS17060 ENOG4105CBS Chea signal transduction histidine kinase F8267_RS17065 ENOG4108V3W Chemotaxis protein, CheW F8267_RS17070 ENOG4105C8Q Methyl-accepting chemotaxis F8267_RS17075 ENOG4105C8Q Methyl-accepting chemotaxis F8267_RS17080 ENOG4105BZU Histidine kinase F8267_RS17090 ENOG4108VYJ response regulator receiver protein F8267_RS17095 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) F8267_RS17100 ENOG4105D00 flagellar biosynthetic protein flhB F8267_RS17105 ENOG4105D7B Flagellar biosynthesis protein flha F8267_RS17115 ENOG4105QVD Flagella synthesis protein FlgN F8267_RS17120 ENOG4105M9M anti-sigma28 factor FlgM F8267_RS17125 ENOG4105CKS Flagella basal body P-ring formation protein flgA F8267_RS17135 ENOG4108ZC9 flagellar basal-body rod protein flgc F8267_RS17140 ENOG4105W00 Flagellar hook capping protein F8267_RS17145 ENOG4105BZE flagellar hook protein, FlgE F8267_RS17150 ENOG4108KPB Flagellar basal-body rod protein FlgF F8267_RS17155 ENOG4105CGA flagellar basal-body rod protein FlgG F8267_RS17170 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj F8267_RS17175 ENOG4105E1Q flagellar hook-associated protein F8267_RS17180 ENOG4105DTJ flagellar hook-associated protein F8267_RS17200 ENOG4105F27 Major Facilitator F8267_RS17210 ENOG4107RGD Major Facilitator superfamily F8267_RS17220 ENOG4107258 Transcriptional regulator F8267_RS17225 ENOG4105JSC dimethylmenaquinone methyltransferase F8267_RS17255 ENOG4105D19 Role in flagellar biosynthesis (By similarity) F8267_RS17260 ENOG4105VS8 Flagellar biosynthetic protein fliq F8267_RS17265 ENOG4105CN7 Flagellar biosynthetic protein FliP F8267_RS17275 ENOG4105DD5 Flagellar motor switch protein F8267_RS17280 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F8267_RS17285 ENOG4107ZI8 flagellar basal body-associated protein flil F8267_RS17290 ENOG4105WF4 Flagellar hook-length control protein F8267_RS17295 ENOG4105GSA Flagellar export protein flij F8267_RS17300 ENOG4108JIR Flagellum-specific ATP synthase F8267_RS17305 ENOG41090PJ Flagellar assembly protein F8267_RS17310 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F8267_RS17315 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) F8267_RS17320 ENOG4105VQ0 flagellar hook-basal body complex protein fliE F8267_RS17350 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) F8267_RS17355 ENOG4105MQ3 flagellar protein FliS F8267_RS17360 ENOG4105DTS flagellar hook-associated F8267_RS17375 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F8267_RS17385 ENOG41063SR receptor F8267_RS17390 ENOG41067XB TonB family F8267_RS17415 ENOG4105E3J oxidoreductase F8267_RS17420 ENOG4105C26 Dehydrogenase F8267_RS17425 ENOG4105DVW rieske (2Fe-2S) F8267_RS17430 ENOG4105C94 Transporter F8267_RS17435 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F8267_RS17440 ENOG4105EJC lysr family transcriptional regulator F8267_RS17445 ENOG4108JPW Aminotransferase F8267_RS17450 ENOG4105CJP fad dependent oxidoreductase F8267_RS17455 ENOG4105C26 Dehydrogenase F8267_RS17460 ENOG4107VRI Transcriptional regulator F8267_RS17465 ENOG4108Z86 Glutamine amidotransferase F8267_RS17470 ENOG4105CFQ glutamine synthetase F8267_RS17475 ENOG4105CUB amino acid F8267_RS17525 ENOG4105D6F Phosphatase F8267_RS17530 ENOG4105XH3 F8267_RS17540 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 F8267_RS17550 ENOG4105C2W permease F8267_RS17560 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) F8267_RS17565 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) F8267_RS17585 ENOG4108R86 Transcriptional regulator F8267_RS17595 ENOG4105C26 Dehydrogenase F8267_RS17600 ENOG4105CK7 Sodium proline symporter F8267_RS17605 ENOG4105IPI Membrane F8267_RS17615 ENOG4105D9N nucleoside F8267_RS17625 ENOG410650H (LipO)protein F8267_RS17630 ENOG4105DBE peroxidase F8267_RS17635 ENOG4105D5M phosphate starvation-inducible protein F8267_RS17650 ENOG4105CHJ isochorismatase hydrolase F8267_RS17655 ENOG4105EUB pirin domain protein F8267_RS17660 ENOG4105HEI LysR family (Transcriptional regulator F8267_RS17680 ENOG4107XHZ cytoplasmic chaperone TorD family protein F8267_RS17685 ENOG4108UQ5 membrane protein YcdZ F8267_RS17705 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) F8267_RS17720 ENOG4105NAC (LipO)protein F8267_RS17725 ENOG4108W47 Acidic protein msyB F8267_RS17735 ENOG4105D1S lipid A biosynthesis F8267_RS17745 ENOG4106974 biofilm formation F8267_RS17750 ENOG4105F76 Sarcosine oxidase F8267_RS17755 ENOG4105PVA Biofilm formation regulatory protein BssS F8267_RS17760 ENOG4105MEA DNA damage-inducible protein i F8267_RS17770 ENOG4105F3T (LipO)protein F8267_RS17780 ENOG4105D9U N-acetyltransferase F8267_RS17785 ENOG4108YXG UPF0502 protein F8267_RS17790 ENOG4105EP9 oxidoreductase F8267_RS17795 ENOG4105CJR Integral membrane protein (MviN F8267_RS17805 ENOG4105EJC lysr family transcriptional regulator F8267_RS17815 ENOG4105EI2 Pseudouridine synthase F8267_RS17820 ENOG4108UHJ MAF-like protein F8267_RS17825 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein F8267_RS17830 ENOG4105VGS 50s ribosomal protein l32 F8267_RS17835 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) F8267_RS17840 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F8267_RS17845 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F8267_RS17850 ENOG4105CHR reductase F8267_RS17855 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F8267_RS17860 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F8267_RS17865 ENOG4105YAZ 4-amino-4-deoxychorismate lyase F8267_RS17870 ENOG4105HHA aminodeoxychorismate lyase F8267_RS17875 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) F8267_RS17880 ENOG4107QRG dna polymerase iii F8267_RS17885 ENOG4105F8V Hydrolase, tatD family F8267_RS17890 ENOG4105CI1 PTS System F8267_RS17895 ENOG4105K59 histidine triad (HIT) protein F8267_RS17900 ENOG41090DQ Lipoprotein F8267_RS17905 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) F8267_RS17920 ENOG4105D0Y UPF0227 protein F8267_RS17925 ENOG4105CEP NADH dehydrogenase F8267_RS17930 ENOG4107MBR 17 kDa surface antigen F8267_RS17940 ENOG4108IND Tetr family transcriptional regulator F8267_RS17945 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction F8267_RS17950 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F8267_RS17955 ENOG4108JA2 transcriptioN-repair coupling factor F8267_RS17960 ENOG4105D60 lipoprotein releasing system transmembrane protein F8267_RS17965 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F8267_RS17970 ENOG4105D60 lipoprotein releasing system transmembrane protein F8267_RS17975 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) F8267_RS17980 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) F8267_RS17985 ENOG4105CEY Amp-dependent synthetase and ligase F8267_RS17990 ENOG4108HM4 ABC transporter F8267_RS17995 ENOG4105D38 putrescine abc transporter F8267_RS18015 ENOG4108UK5 Transposase F8267_RS18020 ENOG4105EZE Cupin 4 family protein F8267_RS18035 ENOG4107QTF adenylosuccinate lyase F8267_RS18040 ENOG41075W9 High frequency lysogenization protein HflD homolog F8267_RS18055 ENOG4108R99 pseudouridine synthase F8267_RS18060 ENOG4108HMX isocitrate dehydrogenase (NADP) F8267_RS18070 ENOG4105N1F Hnh endonuclease F8267_RS18075 ENOG4107SEY Conserved Protein F8267_RS18080 ENOG4108XDN Transcriptional regulator F8267_RS18090 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF F8267_RS18095 ENOG4105C1P efflux transporter, rnd family, mfp subunit F8267_RS18120 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme F8267_RS18130 ENOG4105DTA methyltransferase F8267_RS18140 ENOG4105R3P Inner membrane protein yagU F8267_RS18145 ENOG4105C3G gtp-binding protein F8267_RS18150 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F8267_RS18155 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria F8267_RS18160 ENOG4105CHH sulfate transporter F8267_RS18165 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F8267_RS18170 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) F8267_RS18180 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) F8267_RS18190 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F8267_RS18195 ENOG4108YY7 Invasion gene expression up-regulator SirB F8267_RS18200 ENOG41063JG Transcriptional regulator F8267_RS18205 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F8267_RS18210 ENOG4105EWV Sodium calcium exchanger membrane region F8267_RS18215 ENOG4105WS7 Cation transport regulator F8267_RS18220 ENOG4108NH8 Cation transport protein F8267_RS18230 ENOG41090EX DsrE family F8267_RS18250 ENOG4105D7T ABC transporter F8267_RS18260 ENOG4107QZF nitrite reductase NADPH large subunit F8267_RS18270 ENOG4105ID0 Putative invasin F8267_RS18275 ENOG4105WH1 Two component transcriptional regulator luxr family F8267_RS18280 ENOG4105BZU Histidine kinase F8267_RS18285 ENOG4105DQQ Major facilitator superfamily MFS_1 F8267_RS18290 ENOG4105CRU nitrate reductase, alpha subunit F8267_RS18295 ENOG4108IUE nitrate reductase beta subunit F8267_RS18300 ENOG4105R3A Nitrate reductase F8267_RS18305 ENOG41076YT nitrate reductase, gamma subunit F8267_RS18355 ENOG4105CIY formyltetrahydrofolate deformylase F8267_RS18365 ENOG4105D78 K07001 NTE family protein F8267_RS18370 ENOG4105I93 response regulator F8267_RS18375 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F8267_RS18380 ENOG4108SAU DNA-binding protein H-ns F8267_RS18390 ENOG4105C0A alcohol dehydrogenase F8267_RS18395 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein F8267_RS18400 ENOG4107QSI ABC, transporter F8267_RS18405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F8267_RS18410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F8267_RS18415 ENOG4105C3U ABC transporter F8267_RS18420 ENOG4108JQ7 (ABC) transporter F8267_RS18425 ENOG4105EYW Ion transport protein F8267_RS18430 ENOG4108W5H UPF0263 protein F8267_RS18435 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F8267_RS18450 ENOG4105M5J Cupin 2, conserved barrel domain protein F8267_RS18455 ENOG4105CAZ oligogalacturonide lyase F8267_RS18460 ENOG4105CT4 transporter F8267_RS18495 ENOG4108RAV Conserved protein F8267_RS18500 ENOG4105K9H YciI-like protein F8267_RS18505 ENOG410822N TonB family F8267_RS18515 ENOG4105P10 Uncharacterized protein ydiZ F8267_RS18520 ENOG4105DE4 1-phosphofructokinase F8267_RS18525 ENOG4108NE3 Salt-induced outer membrane protein F8267_RS18535 ENOG4105QFS Lysis protein S homolog from lambdoid prophage F8267_RS18570 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) F8267_RS18575 ENOG41082NX 50s ribosomal protein l35 F8267_RS18580 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) F8267_RS18585 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) F8267_RS18590 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) F8267_RS18595 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) F8267_RS18605 ENOG4105MWK D-amino acid dehydrogenase, small subunit F8267_RS18610 ENOG4105RQF LysR family Transcriptional regulator F8267_RS18620 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) F8267_RS18625 ENOG4105D01 (LipO)protein F8267_RS18630 ENOG4108V06 Glutathione peroxidase F8267_RS18635 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) F8267_RS18640 ENOG4108QBX (LipO)protein F8267_RS18655 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F8267_RS18665 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) F8267_RS18675 ENOG4105IPI Membrane F8267_RS18680 ENOG4105CQB FAD linked oxidase domain protein F8267_RS18685 ENOG4105KA0 thioesterase Superfamily protein F8267_RS18690 ENOG4105KWI UPF0339 protein F8267_RS18695 ENOG4105Y3U Transglycosylase-associated protein F8267_RS18710 ENOG4108Z4V iron-sulfur cluster assembly F8267_RS18715 ENOG4105DIW FeS assembly protein SUFB F8267_RS18720 ENOG4105C3K feS assembly ATPase SufC F8267_RS18725 ENOG4105JRK feS assembly protein SufD F8267_RS18735 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) F8267_RS18740 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F8267_RS18750 ENOG4105CA9 Pyruvate kinase F8267_RS18760 ENOG4105RFR Protein of unknown function (DUF2767) F8267_RS18775 ENOG4105DJB Major Facilitator Superfamily F8267_RS18780 ENOG4105E2X shikimate dehydrogenase F8267_RS18785 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein F8267_RS18790 ENOG4108W0P ABC transporter F8267_RS18795 ENOG4105EHG Permease protein F8267_RS18800 ENOG4105S10 periplasmic binding protein F8267_RS18820 ENOG4108T2C cysteine dioxygenase type I F8267_RS18825 ENOG4105EJC lysr family transcriptional regulator F8267_RS18830 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F8267_RS18850 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F8267_RS18855 ENOG4108IY8 ABC, transporter F8267_RS18865 ENOG4105E0A ABC, transporter F8267_RS18870 ENOG4105DQ5 transport system permease protein F8267_RS18890 ENOG4106PMH Extracellular solute-binding protein family 3 F8267_RS18895 ENOG4105E5Q amino acid AbC transporter F8267_RS18900 ENOG4105CDA abc transporter atp-binding protein F8267_RS18920 ENOG4105EWC Purine nucleoside phosphorylase F8267_RS18945 ENOG4105CHR reductase F8267_RS18950 ENOG4105D29 Helix-turn-helix type 11 domain protein F8267_RS18955 ENOG4105EQ2 LysR family Transcriptional regulator F8267_RS18960 ENOG4107RTG Major Facilitator superfamily F8267_RS18965 ENOG4105ENX hydrolase F8267_RS18970 ENOG410829K Lysine exporter protein (Lyse ygga) F8267_RS18980 ENOG4105C9K Endothelin-converting enzyme 1 F8267_RS18990 ENOG4105R1U AraC Family Transcriptional Regulator F8267_RS19000 ENOG4108UQ8 endoribonuclease L-psp F8267_RS19025 ENOG4105CVJ phosphoglycerate mutase F8267_RS19030 ENOG4108JCI Transcriptional regulator F8267_RS19035 ENOG4105K5X acetyltransferase F8267_RS19050 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) F8267_RS19055 ENOG4105DG4 malate L-lactate dehydrogenase F8267_RS19070 ENOG4107Z33 ABC transporter, permease F8267_RS19100 ENOG4105DA4 cytochrome c-type biogenesis protein F8267_RS19105 ENOG4105CHR reductase F8267_RS19110 ENOG4105C7K acetolactate synthase F8267_RS19125 ENOG4105DTD Dehydrogenase F8267_RS19130 ENOG4105CY2 Citrate transporter F8267_RS19135 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) F8267_RS19140 ENOG4105CHU acetyl-coa acetyltransferase F8267_RS19145 ENOG4107QNJ CoA-transferase subunit B F8267_RS19155 ENOG4106NZI LysR family Transcriptional regulator F8267_RS19165 ENOG4105DZG Dehydrogenase F8267_RS19175 ENOG4108JQ7 (ABC) transporter F8267_RS19180 ENOG4105C3U ABC transporter F8267_RS19205 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase F8267_RS19210 ENOG4105MVE transcriptional regulator F8267_RS19230 ENOG4105C2W permease F8267_RS19235 ENOG4105BZ8 glutamate synthase F8267_RS19240 ENOG4108R8B oxidoreductase Fe-S subunit F8267_RS19245 ENOG4107UUR Chlorohydrolase aminohydrolase F8267_RS19250 ENOG4105BZ8 glutamate synthase F8267_RS19255 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase F8267_RS19260 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC F8267_RS19265 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family F8267_RS19270 ENOG4105C5B carbamate kinase F8267_RS19280 ENOG4107S4Y M20 DapE family protein YgeY F8267_RS19285 ENOG4107RCH Diaminopropionate ammonia-lyase F8267_RS19290 ENOG4105IW6 Carbamoyltransferase F8267_RS19295 ENOG4108JUB Transcriptional regulator F8267_RS19305 ENOG4107B2H carbonic anhydrase F8267_RS19355 ENOG4108URH decarboxylase F8267_RS19360 ENOG4107QI1 Mate efflux family protein F8267_RS19365 ENOG4108R6K riboflavin synthase, subunit alpha F8267_RS19370 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F8267_RS19375 ENOG4105CZQ inner membrane transport protein YdhC F8267_RS19380 ENOG4105F52 Transcriptional regulator F8267_RS19395 ENOG4105F27 Major Facilitator F8267_RS19400 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F8267_RS19405 ENOG41086D8 Transcriptional regulator F8267_RS19410 ENOG4105K4H Nlp p60 protein F8267_RS19415 ENOG4105M2J Glutaredoxin F8267_RS19420 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) F8267_RS19425 ENOG4108UYE Lactoylglutathione lyase F8267_RS19430 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F8267_RS19435 ENOG4108WUH Transcriptional regulator, TetR family F8267_RS19440 ENOG4105XZD Fe-S protein F8267_RS19445 ENOG4107RGM aldo keto reductase F8267_RS19450 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F8267_RS19455 ENOG4105DSW Fusaric acid resistance protein F8267_RS19460 ENOG4105Y49 secretion protein, HlyD family F8267_RS19475 ENOG4105BZU Histidine kinase F8267_RS19480 ENOG4108XTF Outer Membrane Lipoprotein F8267_RS19490 ENOG410642K Lysozyme inhibitor F8267_RS19495 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) F8267_RS19500 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F8267_RS19505 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) F8267_RS19510 ENOG4108K3A Glutathione S-transferase F8267_RS19520 ENOG4105CSM endonuclease III F8267_RS19530 ENOG4108UQQ Electron transport complex F8267_RS19555 ENOG4105M9B inner membrane protein ydgK F8267_RS19565 ENOG4105CS2 ec 3.2.1.21 F8267_RS19575 ENOG4105D9R oxidoreductase F8267_RS19580 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F8267_RS19585 ENOG41064WM Uncharacterized protein YcgX F8267_RS19590 ENOG4105D01 (LipO)protein F8267_RS19610 ENOG41066VF YeeE YedE family protein F8267_RS19615 ENOG41061EV selenium-binding protein YdfZ F8267_RS19620 ENOG4105C87 Aminotransferase class I and II F8267_RS19625 ENOG4105CI1 PTS System F8267_RS19630 ENOG4107P2S Transcriptional regulator F8267_RS19635 ENOG4106J39 exported protein F8267_RS19640 ENOG4105EIP mannose-6-phosphate isomerase F8267_RS19645 ENOG4107GFK fumarate F8267_RS19650 ENOG4105C9Q fumarate hydratase class II F8267_RS19660 ENOG4105JJR Histidine kinase F8267_RS19670 ENOG4107EXC regulatoR F8267_RS19675 ENOG4105RA2 Membrane F8267_RS19680 ENOG410642E Short chain dehydrogenase F8267_RS19685 ENOG4105D5Q Arginine ornithine antiporter F8267_RS19690 ENOG4105C5D exported protein F8267_RS19700 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F8267_RS19705 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F8267_RS19710 ENOG410671Z uncharacterized protein ydiH F8267_RS19715 ENOG4105Q9Y Universal stress protein F8267_RS19720 ENOG4105DS0 Transcriptional regulator, Crp Fnr family F8267_RS19725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F8267_RS19730 ENOG4105CFC Transporter F8267_RS19735 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B F8267_RS19745 ENOG4106KR7 LysR family Transcriptional regulator F8267_RS19750 ENOG4108DG9 Smr protein MutS2 F8267_RS19755 ENOG4107HP6 Transcriptional regulator F8267_RS19765 ENOG4107QNJ CoA-transferase subunit B F8267_RS19770 ENOG4105CHU acetyl-coa acetyltransferase F8267_RS19775 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase F8267_RS19780 ENOG4105F2Z 3-oxoadipate enol-lactonase F8267_RS19785 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase F8267_RS19795 ENOG4107GFK fumarate F8267_RS19815 ENOG4108MRH transcriptional regulatory protein F8267_RS19820 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F8267_RS19825 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate F8267_RS19830 ENOG4105DWT malate dehydrogenase (quinone) F8267_RS19835 ENOG4108K70 Transcriptional regulator F8267_RS19840 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F8267_RS19845 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase F8267_RS19850 ENOG4107TT2 Auxin Efflux Carrier F8267_RS19880 ENOG4105DSF transport protein F8267_RS19885 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) F8267_RS19890 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) F8267_RS19895 ENOG4105BZU Histidine kinase F8267_RS19900 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap F8267_RS19915 ENOG4105CTD carboxy-peptidase F8267_RS19920 ENOG4105D94 Major Facilitator Superfamily F8267_RS19925 ENOG4106NZI LysR family Transcriptional regulator F8267_RS19930 ENOG4105DAG ROK family F8267_RS19935 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F8267_RS19940 ENOG4105CMQ Chloride channel F8267_RS19945 ENOG4108NEM leader-binding protein dmsD F8267_RS19950 ENOG4107KGK dmso reductase anchor subunit F8267_RS19955 ENOG4105QAX Iron-sulfur F8267_RS19960 ENOG4107QY8 reductase F8267_RS19965 ENOG4105KBG Protein of unknown function (DUF1161) F8267_RS19975 ENOG4108MK9 spermidine N(1)-acetyltransferase F8267_RS19985 ENOG4105KK4 UPF0060 membrane protein F8267_RS19990 ENOG4108I5G Major Facilitator superfamily F8267_RS19995 ENOG4105CXK mandelate racemase muconate lactonizing F8267_RS20000 ENOG4105CPQ Dehydrogenase F8267_RS20010 ENOG4105DEI Mannitol dehydrogenase F8267_RS20015 ENOG4108U51 Universal stress protein F8267_RS20020 ENOG4107XBN GntR Family Transcriptional Regulator F8267_RS20025 ENOG4105EMU Dehydrogenase F8267_RS20030 ENOG4105DGW oligopeptidase A F8267_RS20040 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) F8267_RS20045 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) F8267_RS20050 ENOG4105CNT hydrolase family 2 F8267_RS20060 ENOG4105ETE Transcriptional regulator (LacI family F8267_RS20070 ENOG410620I Diguanylate cyclase F8267_RS20080 ENOG4105ETT transcriptional Regulator, LysR family F8267_RS20115 ENOG4105E5W Transporter F8267_RS20120 ENOG4108594 Permease of the drug metabolite transporter F8267_RS20125 ENOG4106DNR multiple antibiotic resistance protein F8267_RS20130 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF F8267_RS20135 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes F8267_RS20145 ENOG4105F27 Major Facilitator F8267_RS20150 ENOG4105JAB phenazine biosynthesis protein, phzf family F8267_RS20155 ENOG4105CHR reductase F8267_RS20175 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F8267_RS20180 ENOG4105C0A alcohol dehydrogenase F8267_RS20185 ENOG4107S2N Type III effector Hrp-dependent F8267_RS20190 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) F8267_RS20195 ENOG4105MVE transcriptional regulator F8267_RS20200 ENOG4105EGI Transcriptional regulator F8267_RS20205 ENOG4105C26 Dehydrogenase F8267_RS20210 ENOG4105CSV Glutaminase F8267_RS20215 ENOG4105M0C cytoplasmic protein F8267_RS20220 ENOG4105BZU Histidine kinase F8267_RS20240 ENOG4105EXW epimerase dehydratase F8267_RS20245 ENOG4105CSP Major Facilitator Superfamily F8267_RS20250 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) F8267_RS20255 ENOG4105FB2 class II Aldolase F8267_RS20260 ENOG4105G63 Type III effector Hrp-dependent F8267_RS20265 ENOG4105MVE transcriptional regulator F8267_RS20285 ENOG4105F9N Major Facilitator Superfamily F8267_RS20295 ENOG4105T38 integral membrane protein F8267_RS20300 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F8267_RS20305 ENOG4105CBP Major Facilitator F8267_RS20310 ENOG4105EGI Transcriptional regulator F8267_RS20315 ENOG4105EA8 2-Nitropropane dioxygenase F8267_RS20320 ENOG4108UMI ABC transporter, permease F8267_RS20330 ENOG4105D01 (LipO)protein F8267_RS20340 ENOG4105VYA Uncharacterized conserved protein (DUF2132) F8267_RS20345 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions F8267_RS20360 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F8267_RS20370 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F8267_RS20380 ENOG4108Z9Z response to DNA damage stimulus F8267_RS20390 ENOG4108N8X transition metal ion binding F8267_RS20395 ENOG4105C4M (Ubiquinol oxidase) subunit I F8267_RS20400 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F8267_RS20420 ENOG4108QY0 Membrane F8267_RS20430 ENOG4108YDI single-species biofilm formation on inanimate substrate F8267_RS20435 ENOG4105C28 cystathionine F8267_RS20450 ENOG4107EFN gluconate transport system permease 3 F8267_RS20455 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) F8267_RS20460 ENOG4105VPI YqaE family transport protein F8267_RS20465 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F8267_RS20470 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain F8267_RS20485 ENOG4105JHE Major Facilitator Superfamily F8267_RS20500 ENOG4105BZU Histidine kinase F8267_RS20510 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) F8267_RS20515 ENOG4107XMU Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F8267_RS20670 ENOG4105C0R drug resistance transporter emrb qaca subfamily F8267_RS20680 ENOG4105C5R Aminotransferase F8267_RS20690 ENOG4105E5Q amino acid AbC transporter F8267_RS20710 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) F8267_RS20735 ENOG410633P Hydantoin racemase F8267_RS20745 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease F8267_RS20750 ENOG4107QUY Guanine deaminase F8267_RS20755 ENOG41084YZ Hydrolase F8267_RS20765 ENOG4105C2W permease F8267_RS20770 ENOG41061H0 Monooxygenase F8267_RS20800 ENOG4108SZE gCN5-related N-acetyltransferase F8267_RS20805 ENOG4105CUY Mechanosensitive ion channel F8267_RS20810 ENOG4108WN0 inhibitor of vertebrate lysozyme F8267_RS20885 ENOG4105CS6 Rhs element vgr protein F8267_RS20905 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F8267_RS20965 ENOG4108WC9 type VI secretion system effector, hcp1 family F8267_RS21010 ENOG4106VK6 Flagellar motor protein F8267_RS21030 ENOG4109076 Conserved Protein F8267_RS21035 ENOG4105F32 YngK protein F8267_RS21045 ENOG4105HEI LysR family (Transcriptional regulator F8267_RS21080 ENOG4105ETU transcriptional activator (TenA F8267_RS21085 ENOG4108YI8 ABC transporter F8267_RS21090 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component F8267_RS21095 ENOG4107Z6I Thiamine biosynthesis protein F8267_RS21100 ENOG4108JPW Aminotransferase F8267_RS21105 ENOG4105DY8 decarboxylase F8267_RS21115 ENOG4105E0F Histidine kinase F8267_RS21130 ENOG4108IGT Dipeptidase F8267_RS21140 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) F8267_RS21160 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF F8267_RS21185 ENOG4106KR7 LysR family Transcriptional regulator F8267_RS21190 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) F8267_RS21195 ENOG4105D6Z AFG1 family ATPase F8267_RS21200 ENOG4105U5Y Transcriptional regulator F8267_RS21215 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic F8267_RS21225 ENOG4108KUU Inner membrane metabolite transport protein ydjE F8267_RS21235 ENOG4105CR8 Transcriptional regulator F8267_RS21240 ENOG4105C5Q Transcriptional regulator F8267_RS21245 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit F8267_RS21250 ENOG4105C4M (Ubiquinol oxidase) subunit I F8267_RS21255 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F8267_RS21265 ENOG4105FFC UPF0187 protein F8267_RS21270 ENOG4105EZR dyp-type peroxidase family protein F8267_RS21285 ENOG4108Z9K Osmotically inducible protein F8267_RS21290 ENOG4105EQ2 LysR family Transcriptional regulator F8267_RS21305 ENOG4107R1I NAD-dependent malic enzyme F8267_RS21310 ENOG4105ETE Transcriptional regulator (LacI family F8267_RS21330 ENOG4105C5H ABC transporter F8267_RS21340 ENOG4105DQ4 alcohol dehydrogenase F8267_RS21345 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein F8267_RS21355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F8267_RS21375 ENOG4105F27 Major Facilitator F8267_RS21380 ENOG4108IV0 ABC, transporter F8267_RS21385 ENOG4105C0Z ABC transporter F8267_RS21390 ENOG4105CF8 branched-chain amino acid ABC transporter, permease F8267_RS21395 ENOG4105C32 Amino acid ABC transporter (Permease) F8267_RS21415 ENOG4105N0V mono-oxygenase ydhR F8267_RS21435 ENOG4108MG3 formate dehydrogenase F8267_RS21440 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein F8267_RS21450 ENOG4105RPH Inner membrane protein YddG F8267_RS21465 ENOG4108UKV benzoate 1,2-dioxygenase F8267_RS21475 ENOG410626B catechol 1,2-dioxygenase F8267_RS21480 ENOG4105NN7 muconolactone delta-isomerase F8267_RS21485 ENOG4105DTQ mandelate racemase muconate lactonizing F8267_RS21490 ENOG4107HP6 Transcriptional regulator F8267_RS21505 ENOG4107QND Nitrite extrusion protein F8267_RS21510 ENOG4105CRU nitrate reductase, alpha subunit F8267_RS21515 ENOG4108IUE nitrate reductase beta subunit F8267_RS21520 ENOG4108NZN Respiratory nitrate reductase 2 delta chain F8267_RS21525 ENOG4105D0D Nitrate reductase 2, gamma subunit F8267_RS21530 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase F8267_RS21535 ENOG4108MEJ flavin reductase domain protein F8267_RS21555 ENOG4108N27 Glutathione S-transferase F8267_RS21560 ENOG4105XPP Protein of unknown function (DUF1275) F8267_RS21565 ENOG4105EAB amino acid AbC transporter F8267_RS21570 ENOG4105CDA abc transporter atp-binding protein F8267_RS21585 ENOG4105EAB amino acid AbC transporter F8267_RS21600 ENOG4105DEN Luciferase family F8267_RS21610 ENOG4105EQ2 LysR family Transcriptional regulator F8267_RS21615 ENOG4105C85 amino acid F8267_RS21625 ENOG4108NS2 receptor F8267_RS21630 ENOG4105CHB tonB-dependent Receptor F8267_RS21635 ENOG41065TG regulatoR F8267_RS21640 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein F8267_RS21650 ENOG4108Z7F N-acetyltransferase F8267_RS21655 ENOG4108T9Y Inner membrane protein ydcZ F8267_RS21660 ENOG4105R71 cytoplasmic protein F8267_RS21665 ENOG4105DEF Extracellular solute-binding protein, family 5 F8267_RS21675 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) F8267_RS21680 ENOG410654E Membrane F8267_RS21695 ENOG4105C26 Dehydrogenase F8267_RS21700 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component F8267_RS21705 ENOG4105D81 ABC transporter, permease F8267_RS21710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F8267_RS21715 ENOG4107TYH extracellular solute-binding protein family 1 F8267_RS21720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F8267_RS21725 ENOG4105C4M (Ubiquinol oxidase) subunit I F8267_RS21730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F8267_RS21740 ENOG4105RR0 Protein of unknown function (DUF2554) F8267_RS21750 ENOG4108JCI Transcriptional regulator F8267_RS21755 ENOG4105DKK Benzoate F8267_RS21760 ENOG4105UEI Transcriptional Regulator AraC Family F8267_RS21765 ENOG4105DWP Membrane F8267_RS21770 ENOG4108KKZ (LipO)protein F8267_RS21775 ENOG4105DEF Extracellular solute-binding protein, family 5 F8267_RS21780 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F8267_RS21785 ENOG41088CC tellurite resistance protein tehB F8267_RS21790 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein F8267_RS21795 ENOG4107WE3 acetyltransferase YdcK F8267_RS21800 ENOG4108Z9I -acetyltransferase F8267_RS21820 ENOG4105E89 ABC transporter F8267_RS21825 ENOG4105CHM Aminotransferase F8267_RS21830 ENOG4108ETY sodium dicarboxylate symporter F8267_RS21835 ENOG4105CHJ isochorismatase hydrolase F8267_RS21840 ENOG4105ETT transcriptional Regulator, LysR family F8267_RS21845 ENOG4105EBR Carboxylesterase F8267_RS21850 ENOG4105E32 cytoplasmic protein F8267_RS21855 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta F8267_RS21860 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha F8267_RS21865 ENOG4105DDW LysR family Transcriptional regulator F8267_RS21905 ENOG4105CPW cytochrome b561 F8267_RS21915 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F8267_RS21920 ENOG4107DB1 DUF218 domain F8267_RS21930 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) F8267_RS21935 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) F8267_RS21940 ENOG4105C26 Dehydrogenase F8267_RS21945 ENOG4105F4X arginine F8267_RS21950 ENOG4105C8Y Acetylornithine aminotransferase F8267_RS21955 ENOG4105D82 Glutamate dehydrogenase F8267_RS21975 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F8267_RS21985 ENOG4105CQ7 ATP-dependent helicase F8267_RS21990 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) F8267_RS22000 ENOG4108Z0R Transferase F8267_RS22005 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein F8267_RS22010 ENOG4105DZS Phenylacetate-CoA ligase F8267_RS22015 ENOG4105CHU acetyl-coa acetyltransferase F8267_RS22020 ENOG4108ZJI phenylacetic acid degradation protein F8267_RS22025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F8267_RS22030 ENOG4108UKI Enoyl-CoA hydratase F8267_RS22035 ENOG4105E39 Enoyl-CoA hydratase F8267_RS22040 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F8267_RS22045 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit F8267_RS22050 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit F8267_RS22055 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit F8267_RS22060 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit F8267_RS22065 ENOG4105DXM phenylacetic acid degradation protein F8267_RS22070 ENOG4105F11 amine oxidase F8267_RS22080 ENOG4105C26 Dehydrogenase F8267_RS22085 ENOG4108WFR AraC Family Transcriptional Regulator F8267_RS22090 ENOG4105WXT Conserved Protein F8267_RS22095 ENOG410689M (LipO)protein F8267_RS22100 ENOG4107H52 Dicarboxylate transport F8267_RS22105 ENOG4108KF1 Membrane F8267_RS22110 ENOG4105C5I Dehydrogenase F8267_RS22115 ENOG41090X5 Heat shock protein hslJ F8267_RS22120 ENOG4105IKK cytoplasmic protein F8267_RS22130 ENOG4105FCK Membrane F8267_RS22135 ENOG4108RW8 Universal stress protein F F8267_RS22140 ENOG41080ET plasmid maintenance system killer protein F8267_RS22145 ENOG41081XE plasmid maintenance system antidote protein, xre family F8267_RS22155 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) F8267_RS22160 ENOG4105C1J atp-dependent rna helicase F8267_RS22165 ENOG4107RX3 Mg2 transporter protein cora family protein F8267_RS22170 ENOG4105KD7 acetyltransferase F8267_RS22175 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) F8267_RS22180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F8267_RS22195 ENOG4108NZE NAGC-like transcriptional regulator F8267_RS22205 ENOG4108JQ6 ABC transporter F8267_RS22210 ENOG4105E98 transcriptional regulator DeoR family F8267_RS22215 ENOG4105D9R oxidoreductase F8267_RS22225 ENOG4107R7Y intracellular protease Pfpi family F8267_RS22245 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F8267_RS22265 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) F8267_RS22270 ENOG4105CT4 transporter F8267_RS22275 ENOG4105DSG hydrolase family 43 F8267_RS22280 ENOG4105CV8 reductase F8267_RS22285 ENOG4105DM4 PTS System F8267_RS22290 ENOG4108YRF PTS System F8267_RS22300 ENOG4105UP7 3-epimerase F8267_RS22305 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC F8267_RS22315 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia F8267_RS22320 ENOG4105ETE Transcriptional regulator (LacI family F8267_RS22325 ENOG4107QSI ABC, transporter F8267_RS22330 ENOG4105KXI murein peptide amidase A F8267_RS22335 ENOG4107S8C mandelate racemase muconate lactonizing F8267_RS22340 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) F8267_RS22345 ENOG4108KK1 membrane protein AbrB duplication F8267_RS22350 ENOG4108JU8 Transcriptional regulator F8267_RS22360 ENOG4105CM6 amino acid regulated cytosolic protein F8267_RS22365 ENOG4105NNG Peripheral inner membrane phage-shock protein F8267_RS22370 ENOG4105FM1 phage shock protein C F8267_RS22375 ENOG4105YYT phage shock protein B F8267_RS22380 ENOG41087YS Phage shock protein A F8267_RS22385 ENOG4105E51 psp operon transcriptional activator F8267_RS22395 ENOG4105CH2 amidohydrolase F8267_RS22410 ENOG4108J59 Extracellular solute-binding protein, family 5 F8267_RS22415 ENOG4108EKA peptide transport system, permease F8267_RS22425 ENOG4106IAW F8267_RS22430 ENOG4105VEQ Cold shock protein F8267_RS22435 ENOG41060EU Cold shock-like protein F8267_RS22440 ENOG4105E2V Glycosyltransferase 36 F8267_RS22445 ENOG4105W3V DNA-binding, transcriptional regulator F8267_RS22455 ENOG4105D1S lipid A biosynthesis F8267_RS22625 ENOG4105NY2 NinB protein F8267_RS22750 ENOG4108UUM single-stranded DNA-binding protein F8267_RS22800 ENOG4108EU3 peptide transport system, permease F8267_RS22805 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein F8267_RS22810 ENOG4108JQ2 peptide transport system atp-binding protein F8267_RS22815 ENOG4105ETS cytosine purines uracil thiamine allantoin F8267_RS22825 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH F8267_RS22830 ENOG4105Q4T oxidoreductase F8267_RS22835 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) F8267_RS22845 ENOG4105N2W Transcriptional regulator F8267_RS22850 ENOG41061RM osmotically inducible lipoprotein F8267_RS22855 ENOG4108ZJT translation initiation factor, Sui1 F8267_RS22865 ENOG4105CFV Tetratricopeptide repeat protein F8267_RS22870 ENOG4105Q4A inner membrane protein yciS F8267_RS22875 ENOG4105EYK Phosphatidylglycerophosphatase B F8267_RS22880 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) F8267_RS22885 ENOG4107QM5 aconitate hydratase F8267_RS22895 ENOG4107R11 Transcriptional regulator F8267_RS22900 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F8267_RS22905 ENOG4105RKX Protein of unknown function (DUF2498) F8267_RS22910 ENOG4105ERU peptidase F8267_RS22915 ENOG4105UBK short-chain dehydrogenase reductase F8267_RS22920 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase F8267_RS22925 ENOG41075H3 AraC family transcriptional regulator F8267_RS22935 ENOG4105CT4 transporter F8267_RS22940 ENOG4105FE9 pseudouridine synthase F8267_RS22955 ENOG4107RTD sua5 ycio yrdc ywlc family protein F8267_RS22960 ENOG4105DB7 PHP domain protein F8267_RS22965 ENOG4105CRQ synthase (Component I) F8267_RS22970 ENOG4108EFP Anthranilate synthase component II F8267_RS22975 ENOG4105DK0 Indole-3-glycerol phosphate synthase F8267_RS22985 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) F8267_RS22995 ENOG4105CPQ Dehydrogenase F8267_RS23000 ENOG4105EFX secretion protein, HlyD family F8267_RS23005 ENOG4105KK7 inner membrane protein YiaW F8267_RS23015 ENOG4108Q2M Transcriptional regulator F8267_RS23020 ENOG4105EIF outer membrane protein W F8267_RS23025 ENOG4105PI0 Ferredoxin F8267_RS23035 ENOG4107835 probably involved in intracellular septation (By similarity) F8267_RS23040 ENOG4105NAU thioesterase Superfamily protein F8267_RS23045 ENOG4107PN8 YfeABCD locus regulator F8267_RS23050 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 F8267_RS23055 ENOG4107K5X Membrane-bound metal-dependent hydrolase F8267_RS23060 ENOG4108ETY sodium dicarboxylate symporter F8267_RS23065 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) F8267_RS23070 ENOG4105CH6 catalase F8267_RS23075 ENOG410901P UPF0249 protein F8267_RS23080 ENOG4105F8D glycoside hydrolase family 4 F8267_RS23085 ENOG4105EZV Transcriptional regulator F8267_RS23090 ENOG4105VCP PTS System F8267_RS23095 ENOG4105CK1 PTS System F8267_RS23100 ENOG4105VZJ PTS System F8267_RS23105 ENOG4105KKI DNA-binding transcriptional activator OsmE F8267_RS23115 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) F8267_RS23120 ENOG4108SPG Periplasmic Protein F8267_RS23125 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) F8267_RS23130 ENOG4105C26 Dehydrogenase F8267_RS23135 ENOG4105F4X arginine F8267_RS23145 ENOG4105CGK Exodeoxyribonuclease III F8267_RS23150 ENOG4108RSN SNARE associated Golgi F8267_RS23155 ENOG4108N5C SNARE associated Golgi protein-related protein F8267_RS23160 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F8267_RS23165 ENOG4105VNH ABC transporter solute-binding protein F8267_RS23170 ENOG4105CXZ ABC transporter, permease F8267_RS23175 ENOG4108VGW abc transporter atp-binding protein F8267_RS23180 ENOG4107RM6 sulfurtransferase F8267_RS23185 ENOG4108T9J Cdp-alcohol phosphatidyltransferase F8267_RS23190 ENOG4105M6F mutator MutT protein F8267_RS23195 ENOG4105D82 Glutamate dehydrogenase F8267_RS23215 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) F8267_RS23220 ENOG4105SBG acid phosphatase F8267_RS23225 ENOG41069NU Nitroreductase F8267_RS23230 ENOG4105D07 Signal peptide peptidase, SppA F8267_RS23235 ENOG4105HDK L-asparaginase F8267_RS23240 ENOG4108RWI nicotinamidase F8267_RS23250 ENOG4105VUT cytoplasmic protein F8267_RS23260 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F8267_RS23265 ENOG4105DSB aldose 1-epimerase F8267_RS23270 ENOG4105GNX MltA-interacting MipA family protein F8267_RS23275 ENOG4105CYN Serine protein kinase F8267_RS23290 ENOG4108KHP Diguanylate cyclase F8267_RS23295 ENOG4108KXH Ybak prolyl-tRNA synthetase associated F8267_RS23300 ENOG4108VMM UPF0756 membrane protein F8267_RS23305 ENOG4105R1U AraC Family Transcriptional Regulator F8267_RS23310 ENOG4105DJ2 Major Facilitator Superfamily F8267_RS23315 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F8267_RS23320 ENOG4105K78 MarR family Transcriptional regulator F8267_RS23325 ENOG4105UCG Domain of unknown function (DUF333) F8267_RS23330 ENOG410620I Diguanylate cyclase F8267_RS23335 ENOG4106G4W F8267_RS23350 ENOG4105S5I Membrane F8267_RS23355 ENOG4108NIW Leucine export protein LeuE F8267_RS23360 ENOG4105D1S lipid A biosynthesis F8267_RS23365 ENOG4105DHT Metal Dependent Phosphohydrolase F8267_RS23370 ENOG4106TD9 Diguanylate cyclase F8267_RS23385 ENOG4105BZU Histidine kinase F8267_RS23400 ENOG4105CNA YD repeat protein F8267_RS23440 ENOG4105CNA YD repeat protein F8267_RS23450 ENOG4105CNA YD repeat protein F8267_RS23460 ENOG4105CS6 Rhs element vgr protein F8267_RS23465 ENOG4105KT5 UmuD protein F8267_RS23470 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F8267_RS23535 ENOG4105CDV Ompa motb domain protein F8267_RS23555 ENOG4105EHG Permease protein F8267_RS23565 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) F8267_RS23580 ENOG4105D3G Pseudouridine synthase F8267_RS23585 ENOG4105EJQ L-serine dehydratase F8267_RS23590 ENOG4105C6N Formate acetyltransferase F8267_RS23595 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F8267_RS23605 ENOG4105C7B Threonine dehydratase F8267_RS23610 ENOG410811B TRANSCRIPTIONal F8267_RS23615 ENOG4105C2C drug resistance transporter, Bcr CflA F8267_RS23630 ENOG4105E0K tonB-dependent siderophore receptor F8267_RS23635 ENOG4106JQ5 Transglycosylase SLT domain F8267_RS23640 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F8267_RS23645 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) F8267_RS23655 ENOG4105MWK D-amino acid dehydrogenase, small subunit F8267_RS23660 ENOG4105ED1 spovr family F8267_RS23665 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) F8267_RS23675 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) F8267_RS23690 ENOG4105EXC Acyl-transferase F8267_RS23700 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase F8267_RS23705 ENOG4105VNG YcgL domain-containing protein F8267_RS23710 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) F8267_RS23715 ENOG4107QMS site-determining protein F8267_RS23725 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) F8267_RS23730 ENOG4105CEY Amp-dependent synthetase and ligase F8267_RS23735 ENOG4105Y4Z Outer Membrane Lipoprotein F8267_RS23740 ENOG41072GX Peptidase M22 Glycoprotease F8267_RS23745 ENOG4105DVT helicase F8267_RS23750 ENOG4105M4H endoribonuclease L-psp F8267_RS23755 ENOG4105X5C UPF0181 protein F8267_RS23765 ENOG4105P8F nudix hydrolase F8267_RS23770 ENOG4105EJQ L-serine dehydratase F8267_RS23775 ENOG4107XTP (EAL) domain protein F8267_RS23780 ENOG4105EE5 Membrane protein terC F8267_RS23785 ENOG4105DAS pts system F8267_RS23790 ENOG4105ETZ PTS System F8267_RS23795 ENOG4105F3R pts system mannose fructose sorbose family iid F8267_RS23800 ENOG4108NK4 UPF0266 membrane protein F8267_RS23805 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) F8267_RS23810 ENOG4105DHI Methyltransferase F8267_RS23815 ENOG4105CJN penicillin-binding protein F8267_RS23830 ENOG4105Q3Y exported protein F8267_RS23840 ENOG4105TIK F8267_RS23845 ENOG4105J4Q Transcriptional regulator F8267_RS23850 ENOG4105C0R drug resistance transporter emrb qaca subfamily F8267_RS23855 ENOG4105D0M Protease HtpX homolog F8267_RS23860 ENOG4105CN1 protease F8267_RS23865 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) F8267_RS23875 ENOG4105H2K paraquat-inducible protein a F8267_RS23880 ENOG4105DY2 Paraquat-inducible protein b F8267_RS23890 ENOG4105WT8 Protein of unknown function (DUF1480) F8267_RS23895 ENOG4105UVW uncharacterized protein yebW F8267_RS23900 ENOG4108R1E Serine threonine protein phosphatase 1 F8267_RS23905 ENOG4108MJ5 VirK protein