locus-tag class description HV042_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV042_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV042_RS00025 ENOG4105CC0 LysR family Transcriptional regulator HV042_RS00035 ENOG410667J hydrolase HV042_RS00040 ENOG4105EMF GntR family transcriptional regulator HV042_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HV042_RS00050 ENOG4108RTU Aldolase HV042_RS00055 ENOG4105CXK mandelate racemase muconate lactonizing HV042_RS00065 ENOG4105C5I Dehydrogenase HV042_RS00070 ENOG4105D99 atp gtp-binding protein HV042_RS00075 ENOG4105R2A (LipO)protein HV042_RS00095 ENOG4105D0C transport protein HV042_RS00100 ENOG4105FDP GntR family transcriptional regulator HV042_RS00105 ENOG4105CI1 PTS System HV042_RS00110 ENOG4105F8D glycoside hydrolase family 4 HV042_RS00115 ENOG4105VG5 Membrane HV042_RS00120 ENOG4105JP4 Inner membrane protein yidG HV042_RS00125 ENOG4105J13 transcriptional regulator HV042_RS00140 ENOG4105W8I Transcriptional regulator HV042_RS00150 ENOG4105E5M Multidrug resistance protein D HV042_RS00175 ENOG4105C7K acetolactate synthase HV042_RS00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV042_RS00190 ENOG4108KX4 response regulator HV042_RS00195 ENOG4105BZU Histidine kinase HV042_RS00200 ENOG4105CXY transporter HV042_RS00205 ENOG4105CXY transporter HV042_RS00210 ENOG4108SAJ Protein of unknown function (DUF1198) HV042_RS00230 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HV042_RS00235 ENOG4105VCP PTS System HV042_RS00240 ENOG4105CK1 PTS System HV042_RS00250 ENOG4105DDV Transcriptional regulator (LacI family HV042_RS00260 ENOG4105DNE Transposase HV042_RS00270 ENOG4108UZ3 Transporter HV042_RS00275 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HV042_RS00280 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV042_RS00285 ENOG4105C2C drug resistance transporter, Bcr CflA HV042_RS00290 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV042_RS00295 ENOG4105BZS acriflavin resistance protein HV042_RS00300 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV042_RS00310 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HV042_RS00320 ENOG4105CR8 Transcriptional regulator HV042_RS00335 ENOG4105D01 (LipO)protein HV042_RS00350 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HV042_RS00355 ENOG4108W3Q Transcriptional regulator HV042_RS00370 ENOG4105NI3 Protein of unknown function (DUF3237) HV042_RS00375 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV042_RS00420 ENOG4105ZTC transcriptional activator, Ogr delta HV042_RS00450 ENOG4105DFP Integrase HV042_RS00460 ENOG4105CT4 transporter HV042_RS00465 ENOG4105CJQ hydrolase, family 31 HV042_RS00470 ENOG4105ETD TRANSCRIPTIONal HV042_RS00475 ENOG4105DM4 PTS System HV042_RS00480 ENOG4108YRF PTS System HV042_RS00485 ENOG4105DM4 PTS System HV042_RS00490 ENOG4105D2N Aldolase HV042_RS00500 ENOG4105DKQ ROK family HV042_RS00515 ENOG4105F8D glycoside hydrolase family 4 HV042_RS00520 ENOG4105CI1 PTS System HV042_RS00525 ENOG4105JV1 AsmA family HV042_RS00530 ENOG4105C2W permease HV042_RS00535 ENOG4105D6U Sodium Glutamate Symporter HV042_RS00545 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV042_RS00550 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HV042_RS00555 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV042_RS00565 ENOG4105CT4 transporter HV042_RS00570 ENOG4105D7K pfkb domain protein HV042_RS00590 ENOG4105CP7 Triose-phosphate isomerase HV042_RS00595 ENOG4105EBK exported protein HV042_RS00600 ENOG4108VTS Membrane HV042_RS00605 ENOG4105DP0 ferredoxin-NADP reductase HV042_RS00610 ENOG4105CBT Fructose-1,6-bisphosphatase HV042_RS00615 ENOG4105CB5 ATP-dependent DNA helicase recG HV042_RS00620 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV042_RS00625 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV042_RS00635 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HV042_RS00640 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HV042_RS00645 ENOG4105EN6 Membrane HV042_RS00655 ENOG4105DSJ YicC domain protein HV042_RS00660 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HV042_RS00665 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HV042_RS00670 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HV042_RS00680 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV042_RS00685 ENOG4105W5Q DNA repair protein (RadC HV042_RS00690 ENOG4105KDC 50s ribosomal protein l28 HV042_RS00695 ENOG4105W0E 50S ribosomal protein L33 HV042_RS00700 ENOG4108M24 von Willebrand factor, type A HV042_RS00730 ENOG4106WTF Glycosyl transferase, family 2 HV042_RS00735 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV042_RS00740 ENOG4105K64 Glycosyl transferase, family 2 HV042_RS00745 ENOG4105CPK Glycosyl transferase (Group 1 HV042_RS00755 ENOG4105DKP glycosyl transferase, family 9 HV042_RS00780 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV042_RS00785 ENOG4105XA0 heptosyltransferase ii HV042_RS00790 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HV042_RS00795 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV042_RS00800 ENOG4105CPQ Dehydrogenase HV042_RS00805 ENOG4106WTF Glycosyl transferase, family 2 HV042_RS00810 ENOG4105PXI polysaccharide deacetylase HV042_RS00815 ENOG41063SB peptidase HV042_RS00825 ENOG4107YZP Rhodanese domain protein HV042_RS00830 ENOG4105VW4 glutaredoxin 3 HV042_RS00835 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HV042_RS00845 ENOG4105D7W serine acetyltransferase HV042_RS00850 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV042_RS00855 ENOG4105DMF Dehydrogenase HV042_RS00860 ENOG41073TP transcriptional regulator HV042_RS00865 ENOG4105DAA L-lactate HV042_RS00870 ENOG4108YYI Protein of unknown function (DUF2810) HV042_RS00880 ENOG4105E61 Mannitol repressor protein HV042_RS00890 ENOG4105CTS PTS system mannitol-specific HV042_RS00895 ENOG4105KK7 inner membrane protein YiaW HV042_RS00900 ENOG4105EFX secretion protein, HlyD family HV042_RS00905 ENOG4108U78 Glutathione S-transferase HV042_RS00910 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HV042_RS00915 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV042_RS00925 ENOG4105CT4 transporter HV042_RS00930 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV042_RS00935 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV042_RS00940 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HV042_RS00945 ENOG4105H6Q decarboxylase HV042_RS00950 ENOG4105CMG Carbohydrate kinase HV042_RS00960 ENOG4108M5W HV042_RS00965 ENOG4108R66 Conserved Protein HV042_RS00970 ENOG4105DG4 malate L-lactate dehydrogenase HV042_RS00975 ENOG4105J4Q Transcriptional regulator HV042_RS00980 ENOG4108RC0 Electron transport protein HV042_RS00985 ENOG4105JKW Valine--pyruvate aminotransferase HV042_RS00990 ENOG4107T9C Alpha amylase catalytic region HV042_RS00995 ENOG4108UR8 BAX protein HV042_RS01000 ENOG4105T16 Transcriptional regulator (AraC family) HV042_RS01005 ENOG4108HWW ABC transporter HV042_RS01015 ENOG4105DFW ABC transporter HV042_RS01020 ENOG4105C93 Xylose Isomerase HV042_RS01025 ENOG4105CMG Carbohydrate kinase HV042_RS01030 ENOG410688U Inner membrane protein yiaB HV042_RS01035 ENOG4105MEV Acyl-transferase HV042_RS01055 ENOG41060TC Hok gef cell toxic protein HV042_RS01070 ENOG4105MVF Transcriptional regulator HV042_RS01075 ENOG4105D2S major facilitator superfamily HV042_RS01080 ENOG4106JH6 (LipO)protein HV042_RS01085 ENOG4105C5I Dehydrogenase HV042_RS01095 ENOG4105D7K pfkb domain protein HV042_RS01105 ENOG4108M60 Transcriptional regulator HV042_RS01110 ENOG4108ZG0 Ompa motb domain protein HV042_RS01115 ENOG4107QY8 reductase HV042_RS01120 ENOG4105HNP -acetyltransferase HV042_RS01125 ENOG4108R3E Dna-3-methyladenine glycosylase i HV042_RS01130 ENOG4105EAX Putative lipase HV042_RS01135 ENOG4105FCD Major Facilitator HV042_RS01140 ENOG4105DIJ Phosphoethanolamine transferase HV042_RS01150 ENOG4105DEF Extracellular solute-binding protein, family 5 HV042_RS01155 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV042_RS01160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV042_RS01165 ENOG4105C3U ABC transporter HV042_RS01170 ENOG4108JQ7 (ABC) transporter HV042_RS01190 ENOG4107EEX Cellulose synthase regulator protein HV042_RS01195 ENOG4105EJG cellulose synthase HV042_RS01215 ENOG4105D1V cellulose synthase operon protein YhjU HV042_RS01220 ENOG4105WQA Cellulose biosynthesis protein BcsF HV042_RS01225 ENOG4105U74 cellulose biosynthesis protein BcsE HV042_RS01230 ENOG410661M cytoplasmic protein HV042_RS01235 ENOG4105UTS cellulose synthase operon protein YhjQ HV042_RS01240 ENOG4107QZ7 Cellulose synthase catalytic subunit HV042_RS01245 ENOG4107EEX Cellulose synthase regulator protein HV042_RS01250 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HV042_RS01255 ENOG4105EJG cellulose synthase HV042_RS01260 ENOG4105BZU Histidine kinase HV042_RS01270 ENOG4105CS0 peptidase HV042_RS01280 ENOG41066T0 asmA family HV042_RS01285 ENOG4105CSH Transporter HV042_RS01290 ENOG4107H3J ribonuclease HV042_RS01295 ENOG4105CBN LysR family transcriptional regulator HV042_RS01300 ENOG4105CHR reductase HV042_RS01305 ENOG4106S2D Transcriptional regulator HV042_RS01325 ENOG4105C0A alcohol dehydrogenase HV042_RS01335 ENOG4105DC8 reductase HV042_RS01340 ENOG4105D6S protein involved in catabolism of external DNA HV042_RS01345 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV042_RS01350 ENOG4105E0F Histidine kinase HV042_RS01360 ENOG4108RRZ Transcription elongation factor GreB HV042_RS01365 ENOG4105BZM domain protein HV042_RS01370 ENOG4105XFK Ferrous iron transport protein A HV042_RS01375 ENOG4105CE1 Ferrous iron transport protein b HV042_RS01380 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HV042_RS01395 ENOG4105MJ2 Competence protein HV042_RS01400 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HV042_RS01405 ENOG4105C6Z Gluconate HV042_RS01410 ENOG4105DGW oligopeptidase A HV042_RS01430 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV042_RS01435 ENOG4105DUX Transporter HV042_RS01445 ENOG4108V6B universal stress protein B HV042_RS01450 ENOG4105CJ3 phosphate transporter HV042_RS01455 ENOG4105CBX hi0933 family HV042_RS01465 ENOG4105F2I Transposase HV042_RS01470 ENOG41069H0 dihydroorotase EC 3.5.2.3 HV042_RS01475 ENOG4107QPK )-transporter HV042_RS01480 ENOG4105JSC dimethylmenaquinone methyltransferase HV042_RS01495 ENOG4105CJW magnesium transporter HV042_RS01505 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV042_RS01510 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV042_RS01515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV042_RS01520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV042_RS01525 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HV042_RS01535 ENOG4105PY6 Phenolic acid decarboxylase HV042_RS01550 ENOG4105C3I Nad-dependent epimerase dehydratase HV042_RS01555 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HV042_RS01560 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HV042_RS01575 ENOG4105DSF transport protein HV042_RS01580 ENOG4105F9N Major Facilitator Superfamily HV042_RS01585 ENOG4108W1V Lipoprotein HV042_RS01590 ENOG4105EX9 Membrane HV042_RS01595 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HV042_RS01605 ENOG4107FS9 Membrane HV042_RS01615 ENOG4105MG3 Membrane HV042_RS01620 ENOG4106H78 methyltransferase HV042_RS01625 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV042_RS01630 ENOG4105CAK Cell division ATP-binding protein ftsE HV042_RS01635 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV042_RS01650 ENOG4108JPW Aminotransferase HV042_RS01655 ENOG4105EQR Transposase IS116 IS110 IS902 HV042_RS01665 ENOG4105CP9 extracellular ligand-binding receptor HV042_RS01670 ENOG4105U59 -acetyltransferase HV042_RS01675 ENOG4105CP9 extracellular ligand-binding receptor HV042_RS01680 ENOG4105C32 Amino acid ABC transporter (Permease) HV042_RS01685 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV042_RS01690 ENOG4105C0Z ABC transporter HV042_RS01695 ENOG4108IV0 ABC, transporter HV042_RS01700 ENOG4105CTX dehydratase HV042_RS01705 ENOG4105CSP Major Facilitator Superfamily HV042_RS01710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS01715 ENOG4107258 Transcriptional regulator HV042_RS01720 ENOG4105BZ7 extracellular solute-binding protein family 1 HV042_RS01725 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV042_RS01740 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV042_RS01745 ENOG4105WC8 Conserved Protein HV042_RS01750 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV042_RS01755 ENOG4105WCN acetyltransferase HV042_RS01765 ENOG4105D9R oxidoreductase HV042_RS01770 ENOG4105C2I pirin domain protein HV042_RS01775 ENOG4105DIQ Transcriptional regulator HV042_RS01780 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV042_RS01785 ENOG4105C6Z Gluconate HV042_RS01800 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV042_RS01805 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV042_RS01825 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV042_RS01830 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV042_RS01840 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HV042_RS01845 ENOG4105E98 transcriptional regulator DeoR family HV042_RS01855 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV042_RS01860 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV042_RS01875 ENOG4105VEJ Heat shock protein HV042_RS01880 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV042_RS01890 ENOG4107RK2 ADP-ribose diphosphatase NudE HV042_RS01895 ENOG4108JQC penicillin-binding protein 1A HV042_RS01905 ENOG41065NF Fimbrial assembly family protein HV042_RS01920 ENOG4105E4G Type IV pilus HV042_RS01925 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV042_RS01930 ENOG4105D49 3-dehydroquinate synthase HV042_RS01935 ENOG4105EGB membrane protein DamX HV042_RS01940 ENOG4105DFE Dna adenine methylase HV042_RS01945 ENOG4105DJV ribulose-phosphate 3-epimerase HV042_RS01955 ENOG4105C31 Tryptophanyl-tRNA synthetase HV042_RS01960 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV042_RS01965 ENOG4107V9H nitrite transporter HV042_RS01970 ENOG4105WZK nitrite reductase NADPH small subunit HV042_RS01975 ENOG4107QZF nitrite reductase NADPH large subunit HV042_RS01980 ENOG4105DZC cytosine deaminase HV042_RS01985 ENOG4106DTQ Protein TsgA homolog HV042_RS01990 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV042_RS02000 ENOG4105MZU cell filamentation protein HV042_RS02010 ENOG4105C8Y Acetylornithine aminotransferase HV042_RS02015 ENOG410613R integral membrane protein, YccS YhfK family HV042_RS02020 ENOG4107RYR Transcriptional regulator, Crp Fnr family HV042_RS02025 ENOG4108UKZ OsmC family HV042_RS02030 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV042_RS02040 ENOG4105DNZ Alpha Beta Hydrolase HV042_RS02050 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV042_RS02060 ENOG4105C5H ABC transporter HV042_RS02065 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HV042_RS02075 ENOG4105VKU nucleicacid-binding protein HV042_RS02080 ENOG4108YZY peptidylprolyl cis-trans isomerase HV042_RS02085 ENOG4105VRX Protein slyX homolog HV042_RS02090 ENOG4108V1T peptidylprolyl cis-trans isomerase HV042_RS02095 ENOG4105WWK YheO domain protein HV042_RS02100 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HV042_RS02110 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV042_RS02115 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HV042_RS02125 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV042_RS02130 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HV042_RS02135 ENOG4105W53 bacterioferritin-associated ferredoxin HV042_RS02140 ENOG4108UQY Iron-storage protein HV042_RS02155 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HV042_RS02160 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HV042_RS02175 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HV042_RS02180 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HV042_RS02185 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HV042_RS02190 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HV042_RS02195 ENOG41083MP 50s ribosomal protein l29 HV042_RS02210 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HV042_RS02215 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HV042_RS02240 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HV042_RS02245 ENOG4105VPB 50S ribosomal protein L30 HV042_RS02250 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HV042_RS02255 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV042_RS02260 ENOG41067V7 50S ribosomal protein L36 HV042_RS02265 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HV042_RS02270 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HV042_RS02275 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HV042_RS02280 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV042_RS02285 ENOG4108ZT0 50S ribosomal protein l17 HV042_RS02290 ENOG4105VTS DnaJ-like, subfamily C HV042_RS02295 ENOG4105W1Y Transcriptional regulator HV042_RS02300 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV042_RS02305 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HV042_RS02310 ENOG4105C1A potassium transporter peripheral membrane HV042_RS02330 ENOG4105C79 DNA protecting protein DprA HV042_RS02340 ENOG4108WI1 Dna topoisomerase HV042_RS02345 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV042_RS02350 ENOG4105E2X shikimate dehydrogenase HV042_RS02355 ENOG4105SG3 Protein of unknown function (DUF1488) HV042_RS02360 ENOG4108Z0R Transferase HV042_RS02395 ENOG4105XCM membrane LIPOPROTEIN HV042_RS02400 ENOG4105BZS acriflavin resistance protein HV042_RS02405 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV042_RS02410 ENOG4108XG4 DNA-binding transcriptional regulator HV042_RS02420 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV042_RS02435 ENOG4108IA2 Sodium pantothenate symporter HV042_RS02440 ENOG4105RG0 Membrane HV042_RS02445 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV042_RS02450 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV042_RS02455 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HV042_RS02465 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV042_RS02470 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV042_RS02480 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV042_RS02485 ENOG4105VQ7 Rod shape-determining protein MreD HV042_RS02490 ENOG4108Z03 MAF-like protein HV042_RS02495 ENOG4105C03 ribonuclease HV042_RS02500 ENOG4105QD6 exported protein HV042_RS02505 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV042_RS02510 ENOG4107EDW L-fucose operon activator HV042_RS02515 ENOG4105CR8 Transcriptional regulator HV042_RS02530 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HV042_RS02535 ENOG4105UNR (Barnase) inhibitor HV042_RS02540 ENOG4105RID UPF0379 protein yhcN HV042_RS02545 ENOG4105RID UPF0379 protein yhcN HV042_RS02550 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV042_RS02570 ENOG4105C8P )-transporter HV042_RS02575 ENOG4106DSS Tartrate dehydratase subunit alpha HV042_RS02580 ENOG4107GFK fumarate HV042_RS02585 ENOG4106AFN Lyase and sodium transporter (By similarity) HV042_RS02590 ENOG4107QSA Oxaloacetate decarboxylase HV042_RS02595 ENOG4105D9Q decarboxylase (Beta subunit) HV042_RS02600 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HV042_RS02605 ENOG4105C0H protease HV042_RS02610 ENOG4105C0H protease HV042_RS02615 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV042_RS02620 ENOG4105D6Z AFG1 family ATPase HV042_RS02625 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HV042_RS02635 ENOG4107MKT Stringent starvation protein a HV042_RS02640 ENOG4105KB2 stringent starvation protein b HV042_RS02650 ENOG4105BZ8 glutamate synthase HV042_RS02655 ENOG4105CBC glutamate synthase HV042_RS02660 ENOG4105N5T Radical SAM Protein HV042_RS02665 ENOG4105BZU Histidine kinase HV042_RS02670 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV042_RS02680 ENOG41080Z8 PHOSPHOCARRIER protein HV042_RS02685 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HV042_RS02690 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV042_RS02695 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV042_RS02700 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV042_RS02705 ENOG4108IUZ ABC transporter HV042_RS02710 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV042_RS02715 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV042_RS02720 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HV042_RS02725 ENOG4105C2X Arabinose 5-phosphate isomerase HV042_RS02730 ENOG4105FEU K -dependent Na -Ca exchanger HV042_RS02735 ENOG4105DHJ ABC, transporter HV042_RS02740 ENOG4105CY3 ABC transporter, permease HV042_RS02745 ENOG4107PE3 Mammalian cell entry related domain protein HV042_RS02750 ENOG4105E3I toluene tolerance HV042_RS02755 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV042_RS02760 ENOG4105VFK BolA family HV042_RS02770 ENOG4105HVQ Regulatory factor of maltose metabolism HV042_RS02775 ENOG4105EAH synthase HV042_RS02780 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HV042_RS02785 ENOG4105K46 50S ribosomal protein l27 HV042_RS02790 ENOG4105QYV Membrane HV042_RS02800 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV042_RS02805 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV042_RS02810 ENOG4105HBR Rna-binding protein HV042_RS02820 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV042_RS02825 ENOG4105EEI dihydropteroate synthase HV042_RS02830 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HV042_RS02835 ENOG4105NTZ Preprotein translocase subunit SecG HV042_RS02845 ENOG4105CDH Citrulline--aspartate ligase HV042_RS02855 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HV042_RS02860 ENOG4105CHV Transcription elongation factor NusA HV042_RS02865 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HV042_RS02870 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HV042_RS02875 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HV042_RS02880 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HV042_RS02885 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HV042_RS02900 ENOG4105C1J atp-dependent rna helicase HV042_RS02905 ENOG4105CIC tryptophan-specific transport protein HV042_RS02910 ENOG4108K70 Transcriptional regulator HV042_RS02930 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HV042_RS02975 ENOG4105DEN Luciferase family HV042_RS02995 ENOG4108YYD acetyltransferase HV042_RS03000 ENOG41082IR Excinuclease ABC C subunit domain protein HV042_RS03005 ENOG4108ZPB UPF0306 protein HV042_RS03010 ENOG4107R7Y intracellular protease Pfpi family HV042_RS03015 ENOG4105K4T epimerase HV042_RS03020 ENOG4107S21 permease HV042_RS03025 ENOG4105W4M Transport-associated protein HV042_RS03030 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HV042_RS03040 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HV042_RS03045 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV042_RS03050 ENOG4107R3N Filamentation induced by cAMP protein fic HV042_RS03060 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HV042_RS03065 ENOG4105DT3 PTS system, galactitol-specific IIc component HV042_RS03070 ENOG41090UW PTS System HV042_RS03075 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HV042_RS03080 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HV042_RS03085 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV042_RS03090 ENOG4105DM4 PTS System HV042_RS03105 ENOG4105E98 transcriptional regulator DeoR family HV042_RS03110 ENOG4107UEK pfkb domain protein HV042_RS03115 ENOG4105CTX dehydratase HV042_RS03120 ENOG4105DJB Major Facilitator Superfamily HV042_RS03125 ENOG4105CNV Aldolase HV042_RS03130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV042_RS03135 ENOG4105BZW Glycerate kinase HV042_RS03160 ENOG4106D80 Uncharacterized protein YhaL HV042_RS03165 ENOG4108CNN domain protein HV042_RS03170 ENOG4105CWB LysR family transcriptional Regulator HV042_RS03175 ENOG4105KAF membrAne HV042_RS03180 ENOG4105CHF Glutathione S-transferase HV042_RS03185 ENOG4108VBZ doxx family HV042_RS03190 ENOG4105YJD HV042_RS03195 ENOG41090KG Inner membrane protein YqjE HV042_RS03200 ENOG4105NE1 Conserved Protein HV042_RS03205 ENOG4105WAY exported protein HV042_RS03210 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HV042_RS03215 ENOG4106W5V Membrane HV042_RS03220 ENOG4107YCY Transcriptional regulator HV042_RS03225 ENOG4105DPW Major facilitator superfamily MFS_1 HV042_RS03235 ENOG4105CTX dehydratase HV042_RS03240 ENOG4105P66 Membrane HV042_RS03250 ENOG4105DU1 integral membrane protein, terc HV042_RS03255 ENOG4105EE0 oxidoreductase HV042_RS03260 ENOG4108VKG metal-dependent hydrolase HV042_RS03265 ENOG4105DSG hydrolase family 43 HV042_RS03275 ENOG4105CT4 transporter HV042_RS03280 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV042_RS03285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV042_RS03290 ENOG4107RYS Autoinducer-2 (AI-2) kinase HV042_RS03295 ENOG4105DKT Transcriptional regulator HV042_RS03300 ENOG4105C2J ABC transporter HV042_RS03305 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HV042_RS03310 ENOG4105F5R ABC transporter HV042_RS03315 ENOG4105D4B ABC, transporter HV042_RS03320 ENOG41061GT Aldolase HV042_RS03325 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HV042_RS03335 ENOG4105NTW Transcriptional regulator HV042_RS03340 ENOG4105Q26 Siderophore-interacting protein HV042_RS03355 ENOG4108UTZ Dihydroxyacetone kinase HV042_RS03360 ENOG4105CMT Dihydroxyacetone kinase HV042_RS03375 ENOG4105V2F Uncharacterized protein yoac HV042_RS03380 ENOG4108KU3 Integrase HV042_RS03460 ENOG4105CAR Terminase, large subunit HV042_RS03490 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV042_RS03495 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV042_RS03540 ENOG4108YZ9 Urea amidohydrolase subunit gamma HV042_RS03545 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV042_RS03555 ENOG4107ZVW dihydroneopterin aldolase HV042_RS03565 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HV042_RS03570 ENOG4106MWK domain protein HV042_RS03575 ENOG4105I7R Adenylate cyclase HV042_RS03600 ENOG4105W0Z cytoplasmic protein HV042_RS03610 ENOG4108MY7 Fimbrial HV042_RS03615 ENOG4108TTM chaperone HV042_RS03625 ENOG4105H8W Fimbrial protein HV042_RS03650 ENOG4108WTW DNA transposition protein HV042_RS03680 ENOG4105ZIA Phage protein gp16 HV042_RS03730 ENOG4108Z6H mu-like prophage Flumu protein gp27 HV042_RS03735 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HV042_RS03755 ENOG4105EFV Major head subunit HV042_RS03785 ENOG4105TKZ Tail Sheath HV042_RS03795 ENOG41062PQ Mu-like prophage FluMu protein gp41 HV042_RS03815 ENOG4105PZ7 Baseplate assembly protein HV042_RS03825 ENOG4108T86 baseplate J family protein HV042_RS03835 ENOG4108X9F tail fiber protein HV042_RS03840 ENOG4105UZW Tail fiber assembly protein HV042_RS03845 ENOG4106IKR HV042_RS03855 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV042_RS03860 ENOG4106032 Glutathionylspermidine synthase HV042_RS03865 ENOG4105F1G UPF0441 protein HV042_RS03875 ENOG41087AY ADP-Ribose pyrophosphatase HV042_RS03880 ENOG4108SX3 cytoplasmic protein HV042_RS03885 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV042_RS03890 ENOG4105IPS esterase HV042_RS03895 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV042_RS03910 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV042_RS03915 ENOG4105EP8 Glycosyl Hydrolase Family 88 HV042_RS03920 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV042_RS03925 ENOG4105NF4 modulator of drug activity HV042_RS03930 ENOG4105DHQ Histidine kinase HV042_RS03935 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV042_RS03940 ENOG4105H4F exported protein HV042_RS03945 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV042_RS03950 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV042_RS03955 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV042_RS03960 ENOG4105CCT upf0313 protein HV042_RS03965 ENOG4105CV8 reductase HV042_RS03970 ENOG4108I6A alcohol dehydrogenase HV042_RS03975 ENOG4105CF7 AraC family transcriptional regulator HV042_RS03980 ENOG4108K81 inner membrane protein YghB HV042_RS03985 ENOG4105C28 cystathionine HV042_RS03990 ENOG4105CWK Biopolymer transport protein, ExbB HV042_RS03995 ENOG4108ZZF transport protein (ExbD) HV042_RS04000 ENOG4108TEB UPF0114 protein HV042_RS04010 ENOG410900S Protein of unknown function (DUF2623) HV042_RS04015 ENOG4105CYM Glutathione S-transferase HV042_RS04025 ENOG4106032 Glutathionylspermidine synthase HV042_RS04030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV042_RS04055 ENOG4105C28 cystathionine HV042_RS04065 ENOG4105C8P )-transporter HV042_RS04075 ENOG4108UQV Membrane HV042_RS04080 ENOG4105CXN decarboxylase HV042_RS04085 ENOG4105EAA nucleoside HV042_RS04095 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HV042_RS04100 ENOG4105CEN a g-specific adenine glycosylase HV042_RS04105 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HV042_RS04110 ENOG41090ED Protein with unknown function (DUF469) HV042_RS04115 ENOG4105K33 Periplasmic Protein HV042_RS04120 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV042_RS04125 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HV042_RS04130 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV042_RS04135 ENOG4105CSA Coproporphyrinogen iii oxidase HV042_RS04145 ENOG4105VZ9 UPF0235 protein HV042_RS04150 ENOG4108VIA integral membrane protein HV042_RS04155 ENOG4105DFA alanine racemase domain protein HV042_RS04160 ENOG4105CZX twitching motility protein HV042_RS04165 ENOG41086KC Transcriptional regulator HV042_RS04175 ENOG4108UJU UPF0301 protein HV042_RS04180 ENOG4105D7Z glutathione synthase HV042_RS04185 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV042_RS04190 ENOG4105RWS endonuclease I HV042_RS04200 ENOG4107QNK )-transporter HV042_RS04205 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HV042_RS04220 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV042_RS04225 ENOG4105CYW agmatinase HV042_RS04230 ENOG4108K0D peptidase, M48 HV042_RS04235 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV042_RS04240 ENOG4108JJB ABC transporter HV042_RS04245 ENOG4108JJB ABC transporter HV042_RS04275 ENOG4105D2N Aldolase HV042_RS04280 ENOG4105D64 Mechanosensitive ion channel HV042_RS04290 ENOG4105MPN Membrane HV042_RS04295 ENOG4105DEQ transcriptional regulator HV042_RS04300 ENOG4105CYC Transferase HV042_RS04305 ENOG4108M7F enoyl-CoA hydratase isomerase HV042_RS04310 ENOG4105DJT lAO AO transport system ATPase HV042_RS04320 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HV042_RS04325 ENOG4105E66 phosphoriboisomerase A HV042_RS04330 ENOG4108JQ1 Dehydrogenase HV042_RS04335 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV042_RS04355 ENOG4107RAQ aminopeptidase HV042_RS04360 ENOG4105D0A hydroxylase HV042_RS04365 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV042_RS04370 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HV042_RS04385 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV042_RS04390 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV042_RS04395 ENOG4105CS2 ec 3.2.1.21 HV042_RS04400 ENOG4108Q3X Transcriptional regulator HV042_RS04405 ENOG4105N5Z UPF0267 protein HV042_RS04410 ENOG4108UT2 hemolysin iii HV042_RS04420 ENOG4105Y75 tpr repeat protein HV042_RS04425 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV042_RS04430 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV042_RS04435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV042_RS04440 ENOG4105T95 Thiol disulfide interChange protein HV042_RS04445 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV042_RS04455 ENOG4105CRK lysyL-tRNA synthetase HV042_RS04460 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HV042_RS04465 ENOG4108UQV Membrane HV042_RS04470 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV042_RS04475 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV042_RS04480 ENOG4106P55 Transcriptional regulator HV042_RS04485 ENOG4108K5P (LipO)protein HV042_RS04510 ENOG41083G8 Multidrug resistance protein MdtM HV042_RS04530 ENOG4105BZW Glycerate kinase HV042_RS04550 ENOG4105CHU acetyl-coa acetyltransferase HV042_RS04555 ENOG4105CHR reductase HV042_RS04560 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HV042_RS04575 ENOG4105EDR glucose galactose transporter HV042_RS04580 ENOG4108RVA ribokinase HV042_RS04585 ENOG4105UP7 3-epimerase HV042_RS04590 ENOG4105E98 transcriptional regulator DeoR family HV042_RS04595 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HV042_RS04600 ENOG4105CMG Carbohydrate kinase HV042_RS04615 ENOG4105D2H Uronic isomerase HV042_RS04620 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HV042_RS04625 ENOG4105DUX Transporter HV042_RS04630 ENOG4105CHR reductase HV042_RS04635 ENOG41061ZR Transcriptional regulator HV042_RS04640 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV042_RS04645 ENOG4108MI0 Resistance protein HV042_RS04650 ENOG4105J12 Multidrug resistance protein mdtN HV042_RS04660 ENOG4105VR1 Pfam:DUF1271 HV042_RS04665 ENOG410830R acetyltransferase HV042_RS04675 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HV042_RS04680 ENOG4108T65 Fimbrial HV042_RS04685 ENOG4108SQA Fimbrial HV042_RS04690 ENOG4105CW0 outer membrane usher protein HV042_RS04695 ENOG4108NAE Fimbrial chaperone protein HV042_RS04700 ENOG4108S54 Fimbrial protein HV042_RS04705 ENOG4108RQP Major type 1 subunit fimbrin HV042_RS04710 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HV042_RS04715 ENOG4108W9T type 1 fimbriae regulatory protein HV042_RS04720 ENOG4108NIW Leucine export protein LeuE HV042_RS04725 ENOG4105EW9 transcriptional regulator AsnC family HV042_RS04730 ENOG4108ZT1 Transcriptional regulator HV042_RS04735 ENOG4108KTG Membrane protein, drug metabolite transporter HV042_RS04755 ENOG4108T1W Fimbrial subunit type 3 HV042_RS04795 ENOG4107S5I aldo keto reductase HV042_RS04800 ENOG4108MHD transport protein HV042_RS04815 ENOG4105CHU acetyl-coa acetyltransferase HV042_RS04820 ENOG4108QGT oligogalacturonate-specific porin HV042_RS04825 ENOG4105CAZ oligogalacturonide lyase HV042_RS04830 ENOG4105CHR reductase HV042_RS04835 ENOG4107QNK )-transporter HV042_RS04840 ENOG4106NDP Transcriptional regulator HV042_RS04845 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV042_RS04850 ENOG4108HKT sucrose-6-phosphate hydrolase HV042_RS04860 ENOG4105CAZ oligogalacturonide lyase HV042_RS04875 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HV042_RS04880 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HV042_RS04895 ENOG4105RQF LysR family Transcriptional regulator HV042_RS04905 ENOG4105DDV Transcriptional regulator (LacI family HV042_RS04910 ENOG4105CK1 PTS System HV042_RS04915 ENOG4105CS2 ec 3.2.1.21 HV042_RS04920 ENOG4107YCY Transcriptional regulator HV042_RS04930 ENOG41060NJ transcriptional regulator HV042_RS04940 ENOG4107S74 Lysophospholipid transporter LplT HV042_RS04945 ENOG4105CPC Aldo Keto reductase HV042_RS04950 ENOG4105SUV lipoprotein YgdR HV042_RS04955 ENOG4105EE5 Membrane protein terC HV042_RS04960 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HV042_RS04970 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV042_RS04975 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HV042_RS04980 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HV042_RS04985 ENOG4105IPU prepilin peptidase dependent protein A HV042_RS04990 ENOG4105JCS prepilin peptidase dependent protein HV042_RS04995 ENOG4105SEN Protein of unknown function (DUF2509) HV042_RS05000 ENOG4105RVB Prepilin peptidase dependent protein c HV042_RS05005 ENOG4105DSY exodeoxyribonuclease V, gamma HV042_RS05010 ENOG4107QXK peptidase HV042_RS05015 ENOG4107QKA exodeoxyribonuclease V beta HV042_RS05020 ENOG4107QYX exodeoxyribonuclease v alpha HV042_RS05025 ENOG4108EKC n-acetylglutamate synthase HV042_RS05030 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV042_RS05035 ENOG4107QZB decarboxylase HV042_RS05040 ENOG4105JZC GHMP kinase HV042_RS05050 ENOG4105KTW ethanolamine utilization protein HV042_RS05055 ENOG4105M3W utilization protein HV042_RS05065 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HV042_RS05070 ENOG4105C0A alcohol dehydrogenase HV042_RS05075 ENOG4108EKI Dehydrogenase HV042_RS05085 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV042_RS05095 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HV042_RS05105 ENOG4105KNY Microcompartments protein HV042_RS05115 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV042_RS05120 ENOG4108ZFT Dehydratase small subunit HV042_RS05125 ENOG4105YCI dehydratase medium subunit HV042_RS05130 ENOG4105DMB glycerol dehydratase HV042_RS05135 ENOG4105EHR propanediol utilization protein pduB HV042_RS05140 ENOG4105KNY Microcompartments protein HV042_RS05145 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV042_RS05150 ENOG4107XVH Transcriptional regulator HV042_RS05155 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV042_RS05160 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HV042_RS05165 ENOG41081F0 Precorrin-8x methylmutase HV042_RS05170 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HV042_RS05175 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HV042_RS05180 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HV042_RS05185 ENOG4105CIA precorrin-4 C(11)-methyltransferase HV042_RS05190 ENOG4108P62 biosynthesis protein (CbiG) HV042_RS05195 ENOG4105E4R Precorrin-3B C17-methyltransferase HV042_RS05200 ENOG4105QUC reductase HV042_RS05205 ENOG4107PPM cobalt chelatase HV042_RS05210 ENOG4105DVK Precorrin-2 c20-methyltransferase HV042_RS05215 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV042_RS05220 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV042_RS05225 ENOG4108V4M Cobalt abc transporter HV042_RS05235 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV042_RS05240 ENOG4108YZT Adenosylcobinamide kinase HV042_RS05265 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV042_RS05270 ENOG4105CUZ uba thif-type nad fad binding protein HV042_RS05275 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV042_RS05280 ENOG4105C9B Cysteine desulfurase HV042_RS05285 ENOG4105M5B (LipO)protein HV042_RS05290 ENOG4105ETT transcriptional Regulator, LysR family HV042_RS05295 ENOG4105M08 Membrane HV042_RS05305 ENOG4107EDW L-fucose operon activator HV042_RS05315 ENOG4105CMG Carbohydrate kinase HV042_RS05320 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HV042_RS05325 ENOG4105EDR glucose galactose transporter HV042_RS05330 ENOG4107W7X Aldolase HV042_RS05335 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HV042_RS05340 ENOG4108JU7 Transcriptional regulator HV042_RS05345 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HV042_RS05360 ENOG4105GVF (ABC) transporter HV042_RS05365 ENOG4105EJQ L-serine dehydratase HV042_RS05370 ENOG4105C44 Serine transporter HV042_RS05375 ENOG4105EWT decarboxylase family HV042_RS05385 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HV042_RS05390 ENOG4105WP7 tRNA pseudouridine synthase C HV042_RS05395 ENOG4105DR9 pseudouridine synthase HV042_RS05400 ENOG4105QDK Flavodoxin HV042_RS05405 ENOG4105DJB Major Facilitator Superfamily HV042_RS05410 ENOG4105EQX glucarate dehydratase HV042_RS05415 ENOG4105EQX glucarate dehydratase HV042_RS05420 ENOG4105BZW Glycerate kinase HV042_RS05425 ENOG4105BZU Histidine kinase HV042_RS05435 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV042_RS05440 ENOG4105DXN mazG family HV042_RS05445 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV042_RS05450 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HV042_RS05460 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV042_RS05465 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV042_RS05470 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HV042_RS05480 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HV042_RS05485 ENOG4105DTT CRISPR-associated helicase, cas3 HV042_RS05500 ENOG41060M0 Crispr-associated protein, cse4 family HV042_RS05515 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HV042_RS05520 ENOG4105PWE CRISPR-associated protein cas2 HV042_RS05525 ENOG4108MXK alkaline phosphatase isozyme conversion HV042_RS05530 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV042_RS05535 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HV042_RS05545 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HV042_RS05550 ENOG4105N0Z inner membrane protein ygbE HV042_RS05555 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV042_RS05560 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HV042_RS05575 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HV042_RS05580 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HV042_RS05585 ENOG4108K5P (LipO)protein HV042_RS05590 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV042_RS05605 ENOG4105JQN Transcriptional regulator HV042_RS05615 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV042_RS05620 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV042_RS05625 ENOG4105KZM cytoplasmic protein HV042_RS05630 ENOG4107635 Hok Gef family protein HV042_RS05635 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HV042_RS05655 ENOG4105HEI LysR family (Transcriptional regulator HV042_RS05670 ENOG4105F2I Transposase HV042_RS05685 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV042_RS05700 ENOG41085W3 Transposase HV042_RS05720 ENOG4105HVQ Regulatory factor of maltose metabolism HV042_RS05735 ENOG4108XS9 dna repair protein HV042_RS05745 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV042_RS05755 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV042_RS05780 ENOG4105CVR type I restriction-modification system HV042_RS05790 ENOG4108HFV HV042_RS05795 ENOG4105DZR Type I site-specific deoxyribonuclease HV042_RS05805 ENOG4105MZU cell filamentation protein HV042_RS05810 ENOG4108TH4 Major fimbrial subunit HV042_RS05820 ENOG4106PG1 outer membrane usher protein HV042_RS05825 ENOG4108FZ9 Chaperone HV042_RS05835 ENOG4108MDY Fimbrial HV042_RS05840 ENOG4108YUF Fimbrial HV042_RS05865 ENOG4105BZ1 (ABC) transporter HV042_RS05870 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV042_RS05880 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV042_RS05900 ENOG4105CHR reductase HV042_RS05925 ENOG4105C0A alcohol dehydrogenase HV042_RS05930 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV042_RS05935 ENOG4105EHG Permease protein HV042_RS05940 ENOG4107R4I Periplasmic binding protein HV042_RS05945 ENOG4106QJH hemin transport protein HV042_RS05960 ENOG4105VXR cytoplasmic protein HV042_RS05965 ENOG4105CC5 ABC transporter HV042_RS05970 ENOG4105CC5 ABC transporter HV042_RS05975 ENOG4105DIK (ABC) transporter HV042_RS05985 ENOG41060NJ transcriptional regulator HV042_RS05990 ENOG4105DKQ ROK family HV042_RS05995 ENOG4105VCP PTS System HV042_RS06000 ENOG4105CK1 PTS System HV042_RS06005 ENOG4105VZJ PTS System HV042_RS06010 ENOG4105CK1 PTS System HV042_RS06025 ENOG4105CS2 ec 3.2.1.21 HV042_RS06040 ENOG4105C45 hydrogenase expression formation protein (HypE) HV042_RS06045 ENOG4105CQS hydrogenase expression formation protein HypD HV042_RS06050 ENOG41083WG hydrogenase assembly chaperone HV042_RS06055 ENOG4107RSS Hydrogenase accessory protein HypB HV042_RS06065 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV042_RS06070 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV042_RS06075 ENOG4107R30 NADH dehydrogenase HV042_RS06080 ENOG4107TDF Formate hydrogenlyase subunit 4 HV042_RS06085 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV042_RS06090 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV042_RS06095 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV042_RS06100 ENOG4105I6X formate hydrogenlyase maturation HV042_RS06105 ENOG4108MG9 hydrogenase 3 maturation protease HV042_RS06110 ENOG4105CS2 ec 3.2.1.21 HV042_RS06115 ENOG4105C5Y PTS System HV042_RS06120 ENOG4105DDV Transcriptional regulator (LacI family HV042_RS06125 ENOG4108RC0 Electron transport protein HV042_RS06130 ENOG4105C8H hydrogenase maturation protein Hypf HV042_RS06160 ENOG410804X Transcriptional regulator HV042_RS06165 ENOG4105J92 DNA-binding transcriptional activator GutM HV042_RS06170 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HV042_RS06175 ENOG4105VI0 Pts system, glucitol sorbitol-specific HV042_RS06180 ENOG4105DZY Pts system, glucitol sorbitol-specific HV042_RS06185 ENOG410787A Pts system, glucitol sorbitol-specific HV042_RS06190 ENOG4105CVE Lytic murein transglycosylase HV042_RS06195 ENOG4105DIK (ABC) transporter HV042_RS06205 ENOG4105DSE periplasmic solute binding protein HV042_RS06210 ENOG4107TH8 cina domain protein HV042_RS06225 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HV042_RS06230 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV042_RS06260 ENOG4105K3G Periplasmic Protein HV042_RS06265 ENOG4107VXZ Hydrolase HV042_RS06270 ENOG4105W39 Membrane HV042_RS06285 ENOG4105E7U AraC family transcriptional regulator HV042_RS06290 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HV042_RS06295 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV042_RS06300 ENOG4105CW7 secretion protein, HlyD family HV042_RS06305 ENOG4105NTK Transcriptional repressor Mpra HV042_RS06310 ENOG4105ZED uncharacterized protein ygaH HV042_RS06315 ENOG4108UMN azlc family HV042_RS06320 ENOG4105GIJ Glycine betaine HV042_RS06325 ENOG4108HQS Glycine betaine HV042_RS06330 ENOG4108IJ7 Glycine betaine HV042_RS06335 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV042_RS06340 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV042_RS06350 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV042_RS06355 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV042_RS06365 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HV042_RS06370 ENOG4108WMJ Protein of unknown function (DUF2002) HV042_RS06375 ENOG4108RNS Exports L-alanine (By similarity) HV042_RS06380 ENOG4108X73 DNA- binding protein HV042_RS06390 ENOG4108V62 Rhodanese domain protein HV042_RS06395 ENOG41080HT Transcriptional regulator, arsr family HV042_RS06400 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HV042_RS06405 ENOG4105C26 Dehydrogenase HV042_RS06415 ENOG4108VCD Chaperone HV042_RS06420 ENOG4105CW0 outer membrane usher protein HV042_RS06435 ENOG4105E89 ABC transporter HV042_RS06445 ENOG4105CHR reductase HV042_RS06450 ENOG4105DXI Major Facilitator superfamily HV042_RS06455 ENOG4105EVZ LysR family transcriptional regulator HV042_RS06460 ENOG4105CYW agmatinase HV042_RS06465 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HV042_RS06470 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HV042_RS06475 ENOG4105MP9 class II Aldolase HV042_RS06480 ENOG4105CDA abc transporter atp-binding protein HV042_RS06485 ENOG4106TNF Periplasmic binding protein HV042_RS06500 ENOG4105CYW agmatinase HV042_RS06505 ENOG4105EVZ LysR family transcriptional regulator HV042_RS06525 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV042_RS06570 ENOG4105DFE Dna adenine methylase HV042_RS06580 ENOG4105VZ1 Replication Protein HV042_RS06590 ENOG4105ED4 portal protein HV042_RS06720 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HV042_RS06725 ENOG4108Z1B Cyclase dehydrase HV042_RS06735 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV042_RS06740 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV042_RS06745 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HV042_RS06755 ENOG4108JU6 CBS domain protein HV042_RS06760 ENOG4106KVJ cytochrome C assembly protein HV042_RS06765 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV042_RS06775 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HV042_RS06800 ENOG41090EK ompa motb domain protein HV042_RS06805 ENOG4108KHX Diguanylate cyclase HV042_RS06810 ENOG4108WS1 HV042_RS06815 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV042_RS06820 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV042_RS06830 ENOG4105CQC Prephenate dehydratase HV042_RS06835 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV042_RS06840 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV042_RS06845 ENOG4105C34 Pseudouridine synthase HV042_RS06850 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV042_RS06855 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV042_RS06880 ENOG4105CSH Transporter HV042_RS06885 ENOG4105T42 (LipO)protein HV042_RS06890 ENOG4105JIM Phosphatidylserine synthase HV042_RS06895 ENOG4105CD5 CoA-binding domain protein HV042_RS06900 ENOG4106IUH DTW domain containing protein HV042_RS06905 ENOG4105K63 Thioredoxin HV042_RS06910 ENOG4105EIB trna rrna methyltransferase HV042_RS06920 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HV042_RS06925 ENOG4105C1J atp-dependent rna helicase HV042_RS06930 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HV042_RS06935 ENOG4108IYU L-aspartate oxidase HV042_RS06950 ENOG41069PW sigma-e factor negative regulatory protein HV042_RS06960 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV042_RS06970 ENOG4105C3F Signal peptidase i HV042_RS06975 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HV042_RS06985 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HV042_RS06990 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV042_RS06995 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HV042_RS07000 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV042_RS07005 ENOG4106G6Q Transcriptional regulator HV042_RS07010 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV042_RS07015 ENOG4108Z6B deaminase HV042_RS07020 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV042_RS07025 ENOG4108ETH Formylglycinamide ribotide synthetase HV042_RS07030 ENOG4107WP9 Histidine kinase HV042_RS07035 ENOG4108SKK alpha helix protein HV042_RS07040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV042_RS07045 ENOG4108YZA Nitrogen regulatory protein pii HV042_RS07060 ENOG4108SB3 DoxX Family HV042_RS07065 ENOG4108NZE NAGC-like transcriptional regulator HV042_RS07070 ENOG4107HQ7 repeat protein HV042_RS07075 ENOG4107QNK )-transporter HV042_RS07080 ENOG4108ZKT aldose 1-epimerase HV042_RS07085 ENOG4105D8G Major Facilitator superfamily HV042_RS07090 ENOG4108MN2 Stationary phase inducible protein CsiE HV042_RS07095 ENOG41065CD Exported protein HV042_RS07100 ENOG4105D7X high-affinity nickel-transporter HV042_RS07105 ENOG4105ECY inositol monophosphatase HV042_RS07110 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HV042_RS07115 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV042_RS07125 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV042_RS07130 ENOG4108Z4V iron-sulfur cluster assembly HV042_RS07140 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HV042_RS07145 ENOG4108ZIT Ferredoxin, 2FE-2S HV042_RS07150 ENOG4105WVQ Fe-S assembly protein IscX HV042_RS07155 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV042_RS07160 ENOG4105YYA enhanced serine sensitivity protein SseB HV042_RS07165 ENOG4105KHC sulfurtransferase HV042_RS07170 ENOG4105DN3 alpha-2-macroglobulin domain protein HV042_RS07175 ENOG4108JQB penicillin-binding protein 1C HV042_RS07180 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HV042_RS07195 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HV042_RS07205 ENOG4105N21 Membrane HV042_RS07210 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV042_RS07215 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HV042_RS07230 ENOG4105VPD cellular component movement HV042_RS07240 ENOG4105D4Y metalloprotease HV042_RS07245 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV042_RS07250 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV042_RS07255 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HV042_RS07270 ENOG41062G3 Protein of unknown function (DUF2633) HV042_RS07275 ENOG4105BZU Histidine kinase HV042_RS07280 ENOG4105C9X ppx gppa phosphatase HV042_RS07285 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HV042_RS07300 ENOG4105CT4 transporter HV042_RS07310 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV042_RS07320 ENOG41066F8 ROK family HV042_RS07325 ENOG4105CS2 ec 3.2.1.21 HV042_RS07330 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HV042_RS07335 ENOG4105C2W permease HV042_RS07340 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV042_RS07345 ENOG4105K89 arsenate reductase HV042_RS07350 ENOG4105ERG peptidase m48, ste24p HV042_RS07355 ENOG4105C02 permease HV042_RS07360 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV042_RS07365 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV042_RS07370 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS07375 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV042_RS07380 ENOG4105C8V SAICAR synthetase HV042_RS07385 ENOG4105CGZ zinc metallopeptidase HV042_RS07390 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HV042_RS07395 ENOG4106KED esterase YpfH HV042_RS07400 ENOG4105XYK UPF0370 protein HV042_RS07410 ENOG4105KUZ arsenate reductase HV042_RS07420 ENOG4105BZS acriflavin resistance protein HV042_RS07425 ENOG4105BZ8 glutamate synthase HV042_RS07430 ENOG4107VIJ nudix hydrolase HV042_RS07435 ENOG4108PVD exported protein HV042_RS07440 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV042_RS07445 ENOG4105C6K Malic enzyme HV042_RS07450 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HV042_RS07455 ENOG4106S4J ethanolamine utilization protein EutP HV042_RS07460 ENOG4105NDK ethanolamine utilization protein HV042_RS07465 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HV042_RS07470 ENOG4108IJ2 phosphate acetyltransferase HV042_RS07475 ENOG4105KNY Microcompartments protein HV042_RS07480 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV042_RS07485 ENOG4108EKI Dehydrogenase HV042_RS07490 ENOG4107YMV ethanolamine utilization protein HV042_RS07495 ENOG4105C0A alcohol dehydrogenase HV042_RS07500 ENOG4105ENY Ethanolamine utilization protein eutH HV042_RS07505 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HV042_RS07510 ENOG4105CPD ethanolamine ammonia-lyase HV042_RS07520 ENOG4106D67 ethanolamine utilization protein HV042_RS07525 ENOG4108X49 Ethanolamine utilization protein EutK HV042_RS07530 ENOG4108K3Z AraC family transcriptional regulator HV042_RS07540 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV042_RS07545 ENOG4108R6G acetyltransferase HV042_RS07550 ENOG4105QZU Inner membrane protein YfeZ HV042_RS07555 ENOG4105E7K (LipO)protein HV042_RS07560 ENOG4105EZR dyp-type peroxidase family protein HV042_RS07565 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV042_RS07570 ENOG4108I5D sulfate abc transporter HV042_RS07575 ENOG4105ECW sulfate abc transporter HV042_RS07580 ENOG4108IJ6 ABC transporter HV042_RS07585 ENOG4105C6T cysteine synthase HV042_RS07590 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HV042_RS07595 ENOG41089BK Glutamine amido-transferase HV042_RS07600 ENOG4105CSW GntR family transcriptional regulator HV042_RS07605 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV042_RS07615 ENOG4105C5Y PTS System HV042_RS07620 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV042_RS07625 ENOG4105KZ7 phosphocarrier protein hpr HV042_RS07630 ENOG4105C6T cysteine synthase HV042_RS07635 ENOG4105EXN Sulfate transport protein CysZ HV042_RS07645 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HV042_RS07650 ENOG4105VRT cytoplasmic protein HV042_RS07655 ENOG4105DHU Bile acid HV042_RS07660 ENOG4108M0I Transcriptional regulator HV042_RS07665 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HV042_RS07670 ENOG4105EAA nucleoside HV042_RS07675 ENOG4105CN8 Transcriptional regulator HV042_RS07700 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HV042_RS07705 ENOG4105GXM Putative transcription regulator (DUF1323) HV042_RS07710 ENOG4105HZG regulatoR HV042_RS07725 ENOG4108KMM Diguanylate cyclase HV042_RS07730 ENOG4105D9N nucleoside HV042_RS07735 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HV042_RS07740 ENOG4109076 Conserved Protein HV042_RS07745 ENOG4105CPC Aldo Keto reductase HV042_RS07750 ENOG4107RA9 decarboxylase HV042_RS07760 ENOG4105CHC glucokinase (EC 2.7.1.2) HV042_RS07765 ENOG4105DY9 regulatoR HV042_RS07770 ENOG4108HRK Histidine kinase HV042_RS07775 ENOG4105CHM Aminotransferase HV042_RS07860 ENOG4105DFP Integrase HV042_RS07910 ENOG4108S1U HV042_RS07920 ENOG4105CFI type iii restriction protein res subunit HV042_RS07970 ENOG4105NVB glycoside hydrolase, family 19 HV042_RS08010 ENOG4105CAR Terminase, large subunit HV042_RS08020 ENOG4105EFC phage portal protein HK97 family HV042_RS08075 ENOG41064PC HV042_RS08135 ENOG4105S64 Formate nitrite transporter HV042_RS08140 ENOG410903C (LipO)protein HV042_RS08145 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV042_RS08150 ENOG4105KZW UPF0381 protein HV042_RS08165 ENOG4108BY2 phosphohistidine phosphatase HV042_RS08175 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HV042_RS08180 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HV042_RS08190 ENOG4105EJ9 Membrane HV042_RS08195 ENOG4108BPE -transporting atpase HV042_RS08200 ENOG4105MH2 YfcL protein HV042_RS08205 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV042_RS08210 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV042_RS08215 ENOG4105F9N Major Facilitator Superfamily HV042_RS08220 ENOG4106WZ1 flagella biosynthesis regulator HV042_RS08230 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV042_RS08240 ENOG4105DQR SNARE associated Golgi HV042_RS08245 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HV042_RS08250 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV042_RS08255 ENOG4108S3P Sporulation domain protein HV042_RS08260 ENOG4105E96 Colicin v production protein HV042_RS08265 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV042_RS08270 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV042_RS08275 ENOG4105E89 ABC transporter HV042_RS08280 ENOG4105E89 ABC transporter HV042_RS08285 ENOG4105DSP amino acid AbC transporter HV042_RS08290 ENOG4106YG3 ABC transporter HV042_RS08295 ENOG4108JEH abc transporter atp-binding protein HV042_RS08300 ENOG4105KNA -acetyltransferase HV042_RS08315 ENOG4105ECP epimerase HV042_RS08320 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV042_RS08325 ENOG4105CYM Glutathione S-transferase HV042_RS08330 ENOG4108SHQ Glutathione S-transferase HV042_RS08335 ENOG4108RE9 Phosphodiesterase HV042_RS08340 ENOG4105PTV Nudix Hydrolase HV042_RS08345 ENOG4105K2J Transcriptional regulator HV042_RS08350 ENOG4106ETB IIa component HV042_RS08360 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV042_RS08365 ENOG4108HHA Transketolase HV042_RS08370 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HV042_RS08375 ENOG4105C6K Malic enzyme HV042_RS08380 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV042_RS08385 ENOG4105PQ6 UPF0208 membrane protein HV042_RS08395 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV042_RS08400 ENOG4107QWE )-transporter HV042_RS08405 ENOG4105DK2 UPF0207 protein HV042_RS08410 ENOG4105CHM Aminotransferase HV042_RS08415 ENOG4107NQ8 LysR family Transcriptional regulator HV042_RS08420 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HV042_RS08425 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV042_RS08430 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV042_RS08435 ENOG4105GKE subunit e HV042_RS08440 ENOG4107QIZ NADH dehydrogenase HV042_RS08445 ENOG4108IEH NADH dehydrogenase subunit g HV042_RS08450 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HV042_RS08460 ENOG4107UFS subunit j HV042_RS08465 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV042_RS08470 ENOG4105D65 subunit l HV042_RS08475 ENOG4105C8S subunit m HV042_RS08480 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV042_RS08485 ENOG4108W9T type 1 fimbriae regulatory protein HV042_RS08495 ENOG4108AF8 Chaperone HV042_RS08500 ENOG4105CW0 outer membrane usher protein HV042_RS08505 ENOG4105MHR Fimbrial protein HV042_RS08515 ENOG4108W9T type 1 fimbriae regulatory protein HV042_RS08520 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV042_RS08525 ENOG4107YB6 acetyltransferase, (GNAT) family HV042_RS08530 ENOG4105E4F Isochorismate synthase HV042_RS08545 ENOG4108IPT Naphthoate synthase HV042_RS08550 ENOG4105DNI Converts SHCHC to OSB (By similarity) HV042_RS08555 ENOG4105CEY Amp-dependent synthetase and ligase HV042_RS08560 ENOG4108R5S membrane HV042_RS08585 ENOG4105DHQ Histidine kinase HV042_RS08600 ENOG4105CH6 catalase HV042_RS08610 ENOG4108EWA cinA-like protein HV042_RS08615 ENOG4107258 Transcriptional regulator HV042_RS08625 ENOG4105CSP Major Facilitator Superfamily HV042_RS08630 ENOG4105CNV Aldolase HV042_RS08635 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV042_RS08640 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HV042_RS08645 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV042_RS08650 ENOG4105CXY transporter HV042_RS08655 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV042_RS08660 ENOG4105XPH Ferredoxin HV042_RS08665 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV042_RS08670 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV042_RS08680 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV042_RS08685 ENOG4105BZU Histidine kinase HV042_RS08690 ENOG41068CG regulatoR HV042_RS08695 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV042_RS08710 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV042_RS08715 ENOG4105CF1 Alkylated DNA repair protein HV042_RS08720 ENOG4105IBP Cyclic peptide transporter HV042_RS08725 ENOG4105CJW magnesium transporter HV042_RS08730 ENOG4105CHH sulfate transporter HV042_RS08750 ENOG4105F4G Membrane HV042_RS08760 ENOG4105E68 Sulfatase HV042_RS08765 ENOG4105PAN UPF0352 protein HV042_RS08770 ENOG4106V8H Nucleoid-associated protein HV042_RS08775 ENOG4105E98 transcriptional regulator DeoR family HV042_RS08780 ENOG4107VIJ nudix hydrolase HV042_RS08790 ENOG4105CFI type iii restriction protein res subunit HV042_RS08795 ENOG4105I08 Pseudouridine synthase HV042_RS08800 ENOG4105C2C drug resistance transporter, Bcr CflA HV042_RS08805 ENOG4105HG6 HV042_RS08810 ENOG4108JQ5 ABC transporter HV042_RS08815 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV042_RS08820 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV042_RS08825 ENOG4105E43 Extracellular solute-binding protein, family 5 HV042_RS08830 ENOG4105CXC rtn protein HV042_RS08835 ENOG4107TT5 NLP P60 protein HV042_RS08840 ENOG41076MN Phosphoesterase, PA-phosphatase related HV042_RS08845 ENOG4105CKI cobalamin synthesis protein HV042_RS08850 ENOG4105DEI Mannitol dehydrogenase HV042_RS08855 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV042_RS08860 ENOG4105KRS Proteinase inhibitor HV042_RS08865 ENOG4105S8Q sugar efflux transporter HV042_RS08870 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV042_RS08875 ENOG4105DE4 1-phosphofructokinase HV042_RS08880 ENOG4105DM4 PTS System HV042_RS08885 ENOG4105DD7 kinase (PfkB family HV042_RS08890 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HV042_RS08895 ENOG4105D9N nucleoside HV042_RS08900 ENOG4105DD7 kinase (PfkB family HV042_RS08905 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HV042_RS08910 ENOG4105HMI Membrane HV042_RS08915 ENOG4105DUM transcriptional regulator, lysR family HV042_RS08920 ENOG4108IQI permease HV042_RS08925 ENOG4105D05 Receptor HV042_RS08935 ENOG4105EUJ GTP cyclohydrolase i HV042_RS08940 ENOG4105DHF Membrane HV042_RS08945 ENOG41060NJ transcriptional regulator HV042_RS08955 ENOG4105C2J ABC transporter HV042_RS08960 ENOG4107SDZ Galactoside transport system permease protein mglC HV042_RS08965 ENOG4106B0W Curli production assembly transport component CsgG HV042_RS08975 ENOG4107Y60 (LipO)protein HV042_RS08980 ENOG4107GZ4 SanA protein HV042_RS08985 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HV042_RS08990 ENOG41067MG lrgb family HV042_RS08995 ENOG4105VAW lrga family HV042_RS09000 ENOG4106KR7 LysR family Transcriptional regulator HV042_RS09020 ENOG4108RXX maleylacetoacetate isomerase HV042_RS09025 ENOG4105MSY salicylate hydroxylase HV042_RS09030 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV042_RS09035 ENOG4105CID antiterminator HV042_RS09045 ENOG4105CS2 ec 3.2.1.21 HV042_RS09050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV042_RS09060 ENOG4105KHU inner membrane protein YohD HV042_RS09065 ENOG41069YE inner membrane protein yohC HV042_RS09070 ENOG41061WM D-Alanyl-D-Alanine HV042_RS09080 ENOG4105CXG d-lactate dehydrogenase HV042_RS09085 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV042_RS09090 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV042_RS09095 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV042_RS09100 ENOG4108IJ8 ABC transporter HV042_RS09105 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV042_RS09115 ENOG4108XDN Transcriptional regulator HV042_RS09120 ENOG4108HRK Histidine kinase HV042_RS09125 ENOG4108NEV two component transcriptional regulator, LytTR family HV042_RS09130 ENOG4108W15 Protein of unknown function (DUF1456) HV042_RS09135 ENOG4106GP0 (LipO)protein HV042_RS09140 ENOG410903U zinc ion binding HV042_RS09145 ENOG4105DEG Vwa containing coxe family protein HV042_RS09150 ENOG4105RD5 HV042_RS09155 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HV042_RS09160 ENOG4108KDT Molybdate metabolism regulator HV042_RS09165 ENOG4108KDT Molybdate metabolism regulator HV042_RS09170 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HV042_RS09175 ENOG4105D1F ATP-binding protein HV042_RS09185 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV042_RS09190 ENOG4105CBN LysR family transcriptional regulator HV042_RS09195 ENOG4105C7N Xanthine uracil vitamin C permease HV042_RS09200 ENOG4105CPN adenine deaminase HV042_RS09205 ENOG4105DUM transcriptional regulator, lysR family HV042_RS09210 ENOG4105EUZ Beta-lactamase domain protein HV042_RS09215 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HV042_RS09220 ENOG4105DWF phosphomethylpyrimidine kinase HV042_RS09225 ENOG4105EIE fructose-bisphosphate aldolase HV042_RS09250 ENOG4105DEI Mannitol dehydrogenase HV042_RS09255 ENOG4105CMG Carbohydrate kinase HV042_RS09260 ENOG4105IE8 Alpha-ketoglutarate permease HV042_RS09265 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV042_RS09270 ENOG4105CXK mandelate racemase muconate lactonizing HV042_RS09275 ENOG4105DEF Extracellular solute-binding protein, family 5 HV042_RS09280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV042_RS09285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV042_RS09295 ENOG4108JQ7 (ABC) transporter HV042_RS09315 ENOG4105CFP Peptidase U32 HV042_RS09320 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV042_RS09325 ENOG4105EB3 Histidine kinase HV042_RS09330 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV042_RS09335 ENOG4105BZS acriflavin resistance protein HV042_RS09345 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV042_RS09350 ENOG4106V2I dimethylaminohydrolase HV042_RS09355 ENOG4106PMH Extracellular solute-binding protein family 3 HV042_RS09360 ENOG4105DSP amino acid AbC transporter HV042_RS09370 ENOG4108RYR transcriptional regulator AsnC family HV042_RS09385 ENOG4105VJY transcriptional regulator HV042_RS09395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV042_RS09400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV042_RS09410 ENOG4108JQ7 (ABC) transporter HV042_RS09420 ENOG4105CK2 sodium dicarboxylate symporter HV042_RS09435 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HV042_RS09445 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV042_RS09450 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV042_RS09455 ENOG4108MG3 formate dehydrogenase HV042_RS09460 ENOG4105BZN citrate synthase HV042_RS09465 ENOG4105R8A Heat shock protein HV042_RS09470 ENOG4105D03 DNA-3-methyladenine glycosylase II HV042_RS09475 ENOG4105DBI uridine monophosphokinase HV042_RS09480 ENOG4105DHP deoxycytidine triphosphate deaminase HV042_RS09485 ENOG4108GAE asmA family HV042_RS09490 ENOG4105EE5 Membrane protein terC HV042_RS09495 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV042_RS09500 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HV042_RS09505 ENOG4108MRJ HV042_RS09510 ENOG4105DAY polysaccharide export protein HV042_RS09525 ENOG4105D3Q Sugar transferase HV042_RS09535 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HV042_RS09555 ENOG4105PSV Polysaccharide Biosynthesis Protein HV042_RS09570 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV042_RS09630 ENOG4105K64 Glycosyl transferase, family 2 HV042_RS09635 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HV042_RS09640 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HV042_RS09650 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV042_RS09655 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV042_RS09660 ENOG4105CIH Imidazole acetol-phosphate transaminase HV042_RS09665 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HV042_RS09670 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HV042_RS09680 ENOG4107SRH Nad-dependent epimerase dehydratase HV042_RS09685 ENOG4105EQ1 Transcriptional regulator HV042_RS09695 ENOG4105CUB amino acid HV042_RS09715 ENOG4105DS4 PAS PAC sensor Signal transduction histidine kinase HV042_RS09800 ENOG4105YVS arsR family transcriptional regulator HV042_RS09805 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV042_RS09810 ENOG4105CJB Exodeoxyribonuclease I HV042_RS09815 ENOG4105DZ1 carboxypeptidase HV042_RS09820 ENOG4108MRJ HV042_RS09830 ENOG4105DR8 Membrane HV042_RS09835 ENOG41090HJ UPF0265 protein HV042_RS09840 ENOG4108YZT Adenosylcobinamide kinase HV042_RS09850 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HV042_RS09860 ENOG41090U3 tautomerase HV042_RS09865 ENOG4105HEI LysR family (Transcriptional regulator HV042_RS09870 ENOG4108KMH lipoate-protein ligase a HV042_RS09875 ENOG4105CSH Transporter HV042_RS09885 ENOG4105BZU Histidine kinase HV042_RS09890 ENOG4108YS1 cytoplasmic protein HV042_RS09900 ENOG4105FDP GntR family transcriptional regulator HV042_RS09905 ENOG4105CI1 PTS System HV042_RS09910 ENOG4105F8D glycoside hydrolase family 4 HV042_RS09920 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HV042_RS09925 ENOG4108T65 Fimbrial HV042_RS09930 ENOG4108SQA Fimbrial HV042_RS09935 ENOG4105CW0 outer membrane usher protein HV042_RS09940 ENOG4108NAE Fimbrial chaperone protein HV042_RS09945 ENOG4108S54 Fimbrial protein HV042_RS09950 ENOG4108RQP Major type 1 subunit fimbrin HV042_RS09955 ENOG4105WH1 Two component transcriptional regulator luxr family HV042_RS09970 ENOG4107R11 Transcriptional regulator HV042_RS09975 ENOG4108PXI ErfK YbiS YcfS YnhG HV042_RS09985 ENOG4105ETT transcriptional Regulator, LysR family HV042_RS09990 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HV042_RS09995 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) HV042_RS10010 ENOG4105GR3 Histidine kinase HV042_RS10025 ENOG4105HVQ Regulatory factor of maltose metabolism HV042_RS10045 ENOG4105UQX Mate efflux family protein HV042_RS10055 ENOG4105FYV Amp nucleosidase HV042_RS10060 ENOG4106GZG polymyxin resistance protein B HV042_RS10085 ENOG4105BZS acriflavin resistance protein HV042_RS10090 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV042_RS10095 ENOG4108U51 Universal stress protein HV042_RS10115 ENOG4105EQ2 LysR family Transcriptional regulator HV042_RS10125 ENOG4108UQ8 endoribonuclease L-psp HV042_RS10140 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HV042_RS10165 ENOG4105ZIT Porin Gram-negative type HV042_RS10170 ENOG4105Y0K Inner membrane protein YedR HV042_RS10175 ENOG4105EST Metal Dependent Phosphohydrolase HV042_RS10180 ENOG4105DVF Cytosine-specific methyltransferase HV042_RS10185 ENOG41090BB DNA mismatch endonuclease (vsr) HV042_RS10190 ENOG4105FDR Membrane HV042_RS10195 ENOG4105CKW Inner membrane protein yedI HV042_RS10200 ENOG4105VNZ cytoplasmic protein HV042_RS10210 ENOG4105YX3 cellular response to acidity HV042_RS10225 ENOG4105JCU Inherit from NOG: (Lipo)protein HV042_RS10230 ENOG4105E5K Alpha-amylase HV042_RS10235 ENOG4105EAB amino acid AbC transporter HV042_RS10245 ENOG4105E5Q amino acid AbC transporter HV042_RS10250 ENOG4105CDA abc transporter atp-binding protein HV042_RS10255 ENOG4105VJY transcriptional regulator HV042_RS10260 ENOG4105XVG cytoplasmic protein HV042_RS10265 ENOG4105WH1 Two component transcriptional regulator luxr family HV042_RS10350 ENOG4105CDU Replicative dna helicase HV042_RS10525 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV042_RS10540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS10545 ENOG4106RHG Yeca family HV042_RS10550 ENOG4105E0U tyrosine-specific transport protein HV042_RS10555 ENOG4105VVZ metal-binding protein HV042_RS10560 ENOG41090A1 ferritin HV042_RS10570 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV042_RS10580 ENOG4105N4N Protein of unknown function (DUF2766) HV042_RS10585 ENOG4105CT4 transporter HV042_RS10600 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV042_RS10610 ENOG4105CNN ABC, transporter HV042_RS10615 ENOG4108K4C ec 3.1.3.12 HV042_RS10620 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HV042_RS10625 ENOG4108VA4 Universal stress protein HV042_RS10635 ENOG4105CT4 transporter HV042_RS10640 ENOG4105F5H Glycosyl Hydrolase Family 88 HV042_RS10645 ENOG4105C75 arginyL-tRNA synthetase HV042_RS10650 ENOG4106ZCM YecM protein HV042_RS10670 ENOG4105WJG Glutathione HV042_RS10675 ENOG41081XQ Conserved Protein HV042_RS10680 ENOG4105D3W isochorismatase HV042_RS10685 ENOG4105C9M aspartyl-trna synthetase HV042_RS10690 ENOG4108TIT dATP pyrophosphohydrolase HV042_RS10695 ENOG4105CDY transcriptional regulatory protein HV042_RS10700 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HV042_RS10705 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HV042_RS10710 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HV042_RS10715 ENOG4105FAV ABC, transporter HV042_RS10725 ENOG4105NXV High-affinity zinc uptake system protein HV042_RS10730 ENOG4105DR5 peptidase HV042_RS10735 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV042_RS10740 ENOG4105CA9 Pyruvate kinase HV042_RS10745 ENOG4106KNT transcriptional regulator HV042_RS10750 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV042_RS10755 ENOG4105C01 Dihydroxy-acid dehydratase HV042_RS10760 ENOG4108UHU Aldolase HV042_RS10770 ENOG4105X2V dna damage-inducible protein HV042_RS10775 ENOG4108Q2J Inner membrane protein YebE HV042_RS10780 ENOG4105CUG Oligopeptidase b HV042_RS10785 ENOG4105UMD exodeoxyribonuclease X HV042_RS10790 ENOG4105MPK DNA polymerase III subunit theta HV042_RS10795 ENOG4105FXM Copper resistance protein HV042_RS10800 ENOG4108PNC copper resistance HV042_RS10805 ENOG4105NKT exported protein HV042_RS10840 ENOG4108MJ5 VirK protein HV042_RS10845 ENOG4108R1E Serine threonine protein phosphatase 1 HV042_RS10850 ENOG4105UVW uncharacterized protein yebW HV042_RS10855 ENOG4105WT8 Protein of unknown function (DUF1480) HV042_RS10865 ENOG4105DY2 Paraquat-inducible protein b HV042_RS10870 ENOG4105H2K paraquat-inducible protein a HV042_RS10875 ENOG4108ZGC gaf domain protein HV042_RS10885 ENOG4105CN1 protease HV042_RS10890 ENOG4105D0M Protease HtpX homolog HV042_RS10895 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV042_RS10900 ENOG4105J4Q Transcriptional regulator HV042_RS10905 ENOG4105TIK HV042_RS10915 ENOG4105Q3Y exported protein HV042_RS10930 ENOG4105CJN penicillin-binding protein HV042_RS10935 ENOG4105DHI Methyltransferase HV042_RS10950 ENOG4105F3R pts system mannose fructose sorbose family iid HV042_RS10955 ENOG4105ETZ PTS System HV042_RS10960 ENOG4105DAS pts system HV042_RS10965 ENOG4105EE5 Membrane protein terC HV042_RS10970 ENOG4107XTP (EAL) domain protein HV042_RS10975 ENOG4105EJQ L-serine dehydratase HV042_RS10980 ENOG4105P8F nudix hydrolase HV042_RS10990 ENOG4105X5C UPF0181 protein HV042_RS10995 ENOG4105EY3 heparinase II III family protein HV042_RS11005 ENOG4105E0S extracellular solute-binding protein family 1 HV042_RS11015 ENOG4105DRS transport system, permease HV042_RS11030 ENOG4105M4H endoribonuclease L-psp HV042_RS11035 ENOG4105DVT helicase HV042_RS11040 ENOG41072GX Peptidase M22 Glycoprotease HV042_RS11045 ENOG4105Y4Z Outer Membrane Lipoprotein HV042_RS11050 ENOG4105CEY Amp-dependent synthetase and ligase HV042_RS11055 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV042_RS11060 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HV042_RS11065 ENOG4107QMS site-determining protein HV042_RS11070 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HV042_RS11075 ENOG4105VNG YcgL domain-containing protein HV042_RS11080 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV042_RS11085 ENOG4108ZZ3 UPF0260 protein HV042_RS11095 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV042_RS11100 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV042_RS11105 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HV042_RS11110 ENOG4105ED1 spovr family HV042_RS11115 ENOG4105MWK D-amino acid dehydrogenase, small subunit HV042_RS11125 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HV042_RS11130 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV042_RS11135 ENOG4106JQ5 Transglycosylase SLT domain HV042_RS11155 ENOG4105CT4 transporter HV042_RS11165 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein HV042_RS11220 ENOG4105E90 ABC transporter HV042_RS11225 ENOG4105E90 ABC transporter HV042_RS11230 ENOG4108IJ8 ABC transporter HV042_RS11235 ENOG4105D3G Pseudouridine synthase HV042_RS11240 ENOG4107YNJ LysR family Transcriptional regulator HV042_RS11245 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HV042_RS11260 ENOG4105VT2 5-hydroxyisourate hydrolase HV042_RS11265 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV042_RS11270 ENOG4105C54 Major Facilitator superfamily HV042_RS11285 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HV042_RS11295 ENOG4105C2W permease HV042_RS11300 ENOG4105BZ8 glutamate synthase HV042_RS11305 ENOG4108R8B oxidoreductase Fe-S subunit HV042_RS11310 ENOG4107UUR Chlorohydrolase aminohydrolase HV042_RS11315 ENOG4105BZ8 glutamate synthase HV042_RS11320 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HV042_RS11325 ENOG4105C5B carbamate kinase HV042_RS11335 ENOG4107S4Y M20 DapE family protein YgeY HV042_RS11340 ENOG4107RCH Diaminopropionate ammonia-lyase HV042_RS11345 ENOG4105IW6 Carbamoyltransferase HV042_RS11350 ENOG4108JUB Transcriptional regulator HV042_RS11355 ENOG4105C3G gtp-binding protein HV042_RS11360 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HV042_RS11365 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV042_RS11375 ENOG4105CHH sulfate transporter HV042_RS11380 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV042_RS11385 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HV042_RS11400 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HV042_RS11405 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HV042_RS11410 ENOG4108YY7 Invasion gene expression up-regulator SirB HV042_RS11415 ENOG41063JG Transcriptional regulator HV042_RS11420 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HV042_RS11425 ENOG4105EWV Sodium calcium exchanger membrane region HV042_RS11430 ENOG4105WS7 Cation transport regulator HV042_RS11435 ENOG4108NH8 Cation transport protein HV042_RS11445 ENOG41090EX DsrE family HV042_RS11465 ENOG4105D7T ABC transporter HV042_RS11470 ENOG4107QZF nitrite reductase NADPH large subunit HV042_RS11480 ENOG4105ID0 Putative invasin HV042_RS11485 ENOG4105WH1 Two component transcriptional regulator luxr family HV042_RS11490 ENOG4105BZU Histidine kinase HV042_RS11495 ENOG4105DQQ Major facilitator superfamily MFS_1 HV042_RS11500 ENOG4105CRU nitrate reductase, alpha subunit HV042_RS11505 ENOG4108IUE nitrate reductase beta subunit HV042_RS11510 ENOG4105R3A Nitrate reductase HV042_RS11515 ENOG41076YT nitrate reductase, gamma subunit HV042_RS11545 ENOG4105CIY formyltetrahydrofolate deformylase HV042_RS11555 ENOG4105D78 K07001 NTE family protein HV042_RS11560 ENOG4105I93 response regulator HV042_RS11565 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV042_RS11570 ENOG4108SAU DNA-binding protein H-ns HV042_RS11575 ENOG4105F2I Transposase HV042_RS11585 ENOG4105C0A alcohol dehydrogenase HV042_RS11590 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV042_RS11595 ENOG4107QSI ABC, transporter HV042_RS11600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV042_RS11605 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV042_RS11610 ENOG4105C3U ABC transporter HV042_RS11615 ENOG4108JQ7 (ABC) transporter HV042_RS11620 ENOG4105EYW Ion transport protein HV042_RS11625 ENOG4108W5H UPF0263 protein HV042_RS11630 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HV042_RS11640 ENOG4105K9H YciI-like protein HV042_RS11645 ENOG410822N TonB family HV042_RS11655 ENOG4105P10 Uncharacterized protein ydiZ HV042_RS11660 ENOG4105DE4 1-phosphofructokinase HV042_RS11665 ENOG4108NE3 Salt-induced outer membrane protein HV042_RS11680 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV042_RS11685 ENOG41082NX 50s ribosomal protein l35 HV042_RS11690 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HV042_RS11700 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HV042_RS11705 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HV042_RS11710 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV042_RS11715 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HV042_RS11720 ENOG4105D01 (LipO)protein HV042_RS11725 ENOG4108V06 Glutathione peroxidase HV042_RS11730 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HV042_RS11735 ENOG4108QBX (LipO)protein HV042_RS11740 ENOG4105CNG UPF0061 protein HV042_RS11750 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV042_RS11760 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV042_RS11770 ENOG4105IPI Membrane HV042_RS11775 ENOG4105CQB FAD linked oxidase domain protein HV042_RS11780 ENOG4105KA0 thioesterase Superfamily protein HV042_RS11785 ENOG4105Y3U Transglycosylase-associated protein HV042_RS11790 ENOG4108PNB DNA-binding transcriptional regulator HV042_RS11795 ENOG4108PNB DNA-binding transcriptional regulator HV042_RS11805 ENOG4108VCD Chaperone HV042_RS11810 ENOG4105CW0 outer membrane usher protein HV042_RS11825 ENOG4108Z4V iron-sulfur cluster assembly HV042_RS11830 ENOG4105DIW FeS assembly protein SUFB HV042_RS11835 ENOG4105C3K feS assembly ATPase SufC HV042_RS11840 ENOG4105JRK feS assembly protein SufD HV042_RS11850 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV042_RS11855 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV042_RS11865 ENOG4105CA9 Pyruvate kinase HV042_RS11870 ENOG4105RFR Protein of unknown function (DUF2767) HV042_RS11885 ENOG4105DJB Major Facilitator Superfamily HV042_RS11890 ENOG4107V59 shikimate HV042_RS11895 ENOG4108K2P TRANSCRIPTIONal HV042_RS11915 ENOG4105IKQ hydratase HV042_RS11930 ENOG4108SC4 )-transporter HV042_RS11945 ENOG4108T2C cysteine dioxygenase type I HV042_RS11950 ENOG4105W7K Transcriptional regulator HV042_RS11955 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HV042_RS11960 ENOG4105FDT acyl-CoA dehydrogenase HV042_RS11975 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV042_RS11980 ENOG4105E2Y ABC, transporter HV042_RS11990 ENOG4105E0A ABC, transporter HV042_RS11995 ENOG4105DQ5 transport system permease protein HV042_RS12015 ENOG4106PMH Extracellular solute-binding protein family 3 HV042_RS12020 ENOG4105E5Q amino acid AbC transporter HV042_RS12025 ENOG4105CDA abc transporter atp-binding protein HV042_RS12045 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV042_RS12050 ENOG4105DG4 malate L-lactate dehydrogenase HV042_RS12060 ENOG4107Z33 ABC transporter, permease HV042_RS12070 ENOG4105CHR reductase HV042_RS12075 ENOG4105C7K acetolactate synthase HV042_RS12090 ENOG41060EU Cold shock-like protein HV042_RS12095 ENOG4105C28 cystathionine HV042_RS12100 ENOG4107S6Z Na H antiporter HV042_RS12105 ENOG4105CEM UPF0597 protein HV042_RS12120 ENOG4105DZG Dehydrogenase HV042_RS12125 ENOG4108JQ7 (ABC) transporter HV042_RS12130 ENOG4105C3U ABC transporter HV042_RS12145 ENOG4105DEF Extracellular solute-binding protein, family 5 HV042_RS12155 ENOG4105D01 (LipO)protein HV042_RS12160 ENOG4108UMI ABC transporter, permease HV042_RS12165 ENOG4107T8P acyl-Coa dehydrogenase HV042_RS12175 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HV042_RS12180 ENOG4105MVE transcriptional regulator HV042_RS12190 ENOG4107B2H carbonic anhydrase HV042_RS12200 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV042_RS12205 ENOG4108YDI single-species biofilm formation on inanimate substrate HV042_RS12215 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV042_RS12230 ENOG4108QY0 Membrane HV042_RS12235 ENOG4108WTK competence damage-inducible protein HV042_RS12245 ENOG4105CG3 alpha amylase, catalytic region HV042_RS12250 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV042_RS12255 ENOG4105C4M (Ubiquinol oxidase) subunit I HV042_RS12260 ENOG4105WEF catalase HV042_RS12265 ENOG4108N8X transition metal ion binding HV042_RS12270 ENOG4108Z9Z response to DNA damage stimulus HV042_RS12295 ENOG4107QI1 Mate efflux family protein HV042_RS12300 ENOG4108R6K riboflavin synthase, subunit alpha HV042_RS12305 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV042_RS12310 ENOG4105CZQ inner membrane transport protein YdhC HV042_RS12315 ENOG4105F52 Transcriptional regulator HV042_RS12330 ENOG4105F27 Major Facilitator HV042_RS12335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV042_RS12355 ENOG4108C33 Resolvase HV042_RS12380 ENOG4105K4H Nlp p60 protein HV042_RS12385 ENOG4105M2J Glutaredoxin HV042_RS12390 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV042_RS12395 ENOG4108UYE Lactoylglutathione lyase HV042_RS12400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV042_RS12405 ENOG4108WUH Transcriptional regulator, TetR family HV042_RS12410 ENOG4105XZD Fe-S protein HV042_RS12415 ENOG4107RGM aldo keto reductase HV042_RS12420 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV042_RS12425 ENOG4105DSW Fusaric acid resistance protein HV042_RS12430 ENOG4105Y49 secretion protein, HlyD family HV042_RS12445 ENOG4105BZU Histidine kinase HV042_RS12450 ENOG4108XTF Outer Membrane Lipoprotein HV042_RS12455 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HV042_RS12460 ENOG410642K Lysozyme inhibitor HV042_RS12465 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HV042_RS12470 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HV042_RS12480 ENOG4108K3A Glutathione S-transferase HV042_RS12485 ENOG4105DUX Transporter HV042_RS12490 ENOG4105CSM endonuclease III HV042_RS12500 ENOG4108UQQ Electron transport complex HV042_RS12525 ENOG4105M9B inner membrane protein ydgK HV042_RS12535 ENOG4105CS2 ec 3.2.1.21 HV042_RS12545 ENOG4105D9R oxidoreductase HV042_RS12555 ENOG4105D01 (LipO)protein HV042_RS12565 ENOG41066VF YeeE YedE family protein HV042_RS12570 ENOG41061EV selenium-binding protein YdfZ HV042_RS12575 ENOG4105C87 Aminotransferase class I and II HV042_RS12580 ENOG4105CI1 PTS System HV042_RS12585 ENOG4107P2S Transcriptional regulator HV042_RS12590 ENOG4106J39 exported protein HV042_RS12595 ENOG4105EIP mannose-6-phosphate isomerase HV042_RS12600 ENOG4107GFK fumarate HV042_RS12605 ENOG4105C9Q fumarate hydratase class II HV042_RS12615 ENOG4105JJR Histidine kinase HV042_RS12620 ENOG4105BZU Histidine kinase HV042_RS12625 ENOG4107EXC regulatoR HV042_RS12635 ENOG4105F2I Transposase HV042_RS12640 ENOG4105RA2 Membrane HV042_RS12645 ENOG410642E Short chain dehydrogenase HV042_RS12650 ENOG4105D5Q Arginine ornithine antiporter HV042_RS12655 ENOG4105C5D exported protein HV042_RS12665 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV042_RS12670 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV042_RS12675 ENOG410671Z uncharacterized protein ydiH HV042_RS12680 ENOG4105Q9Y Universal stress protein HV042_RS12685 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV042_RS12690 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV042_RS12695 ENOG4105CFC Transporter HV042_RS12700 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HV042_RS12710 ENOG4106KR7 LysR family Transcriptional regulator HV042_RS12715 ENOG4108DG9 Smr protein MutS2 HV042_RS12720 ENOG4107HP6 Transcriptional regulator HV042_RS12730 ENOG4107QNJ CoA-transferase subunit B HV042_RS12735 ENOG4105CHU acetyl-coa acetyltransferase HV042_RS12740 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HV042_RS12745 ENOG4105F2Z 3-oxoadipate enol-lactonase HV042_RS12750 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HV042_RS12755 ENOG4107GFK fumarate HV042_RS12775 ENOG4108MRH transcriptional regulatory protein HV042_RS12780 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV042_RS12785 ENOG4105EQ2 LysR family Transcriptional regulator HV042_RS12790 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HV042_RS12795 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV042_RS12800 ENOG4105DWT malate dehydrogenase (quinone) HV042_RS12805 ENOG4108K70 Transcriptional regulator HV042_RS12810 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV042_RS12815 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HV042_RS12820 ENOG4107TT2 Auxin Efflux Carrier HV042_RS12850 ENOG4105DSF transport protein HV042_RS12855 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HV042_RS12865 ENOG4105BZU Histidine kinase HV042_RS12870 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV042_RS12885 ENOG4105CTD carboxy-peptidase HV042_RS12890 ENOG4105D94 Major Facilitator Superfamily HV042_RS12895 ENOG4106NZI LysR family Transcriptional regulator HV042_RS12900 ENOG4105DAG ROK family HV042_RS12905 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV042_RS12910 ENOG4105CMQ Chloride channel HV042_RS12915 ENOG4108NEM leader-binding protein dmsD HV042_RS12920 ENOG4107KGK dmso reductase anchor subunit HV042_RS12925 ENOG4105QAX Iron-sulfur HV042_RS12930 ENOG4107QY8 reductase HV042_RS12935 ENOG4105KBG Protein of unknown function (DUF1161) HV042_RS12945 ENOG4108MK9 spermidine N(1)-acetyltransferase HV042_RS12950 ENOG4105M5Q UPF0482 protein HV042_RS12960 ENOG4105CXK mandelate racemase muconate lactonizing HV042_RS12965 ENOG4105CPQ Dehydrogenase HV042_RS12975 ENOG4105DEI Mannitol dehydrogenase HV042_RS12980 ENOG4108U51 Universal stress protein HV042_RS12985 ENOG4107XBN GntR Family Transcriptional Regulator HV042_RS12990 ENOG4105EMU Dehydrogenase HV042_RS12995 ENOG4105DGW oligopeptidase A HV042_RS13010 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV042_RS13040 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV042_RS13045 ENOG4105CNT hydrolase family 2 HV042_RS13050 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS13060 ENOG4105BZU Histidine kinase HV042_RS13090 ENOG4105D5K Hemolysin activator protein HV042_RS13095 ENOG4105CKT filamentous hemagglutinin HV042_RS13135 ENOG4105C32 Amino acid ABC transporter (Permease) HV042_RS13140 ENOG4105CNN ABC, transporter HV042_RS13145 ENOG4105C2J ABC transporter HV042_RS13150 ENOG4108IV0 ABC, transporter HV042_RS13160 ENOG4105E5W Transporter HV042_RS13165 ENOG4108594 Permease of the drug metabolite transporter HV042_RS13170 ENOG4106DNR multiple antibiotic resistance protein HV042_RS13175 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV042_RS13180 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV042_RS13190 ENOG4105F27 Major Facilitator HV042_RS13195 ENOG4105JAB phenazine biosynthesis protein, phzf family HV042_RS13200 ENOG4105JAB phenazine biosynthesis protein, phzf family HV042_RS13210 ENOG4105XEP YhcH YjgK YiaL family protein HV042_RS13220 ENOG4105EE5 Membrane protein terC HV042_RS13225 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS13230 ENOG4105C0A alcohol dehydrogenase HV042_RS13235 ENOG4107S2N Type III effector Hrp-dependent HV042_RS13240 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HV042_RS13245 ENOG4105MVE transcriptional regulator HV042_RS13250 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HV042_RS13260 ENOG4105EGI Transcriptional regulator HV042_RS13265 ENOG4105C26 Dehydrogenase HV042_RS13270 ENOG4105CSV Glutaminase HV042_RS13275 ENOG4105M0C cytoplasmic protein HV042_RS13280 ENOG4105BZU Histidine kinase HV042_RS13325 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HV042_RS13330 ENOG4108IJF Heavy metal efflux pump, CzcA HV042_RS13355 ENOG4105F2I Transposase HV042_RS13360 ENOG4105C2C drug resistance transporter, Bcr CflA HV042_RS13365 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV042_RS13385 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV042_RS13420 ENOG410829K Lysine exporter protein (Lyse ygga) HV042_RS13425 ENOG4105CBP Major Facilitator HV042_RS13430 ENOG4105EGI Transcriptional regulator HV042_RS13440 ENOG4108UMI ABC transporter, permease HV042_RS13450 ENOG4105D01 (LipO)protein HV042_RS13460 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HV042_RS13470 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV042_RS13480 ENOG4105E5Q amino acid AbC transporter HV042_RS13505 ENOG4105II7 pyrroline-5-carboxylate reductase HV042_RS13510 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HV042_RS13520 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV042_RS13530 ENOG4105CK1 PTS System HV042_RS13545 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV042_RS13550 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV042_RS13555 ENOG4105EHG Permease protein HV042_RS13570 ENOG4105DT3 PTS system, galactitol-specific IIc component HV042_RS13575 ENOG4108M3J Dehydrogenase HV042_RS13580 ENOG4105CHR reductase HV042_RS13585 ENOG4105CMG Carbohydrate kinase HV042_RS13595 ENOG41061GT Aldolase HV042_RS13615 ENOG4105CNN ABC, transporter HV042_RS13625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV042_RS13630 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS13635 ENOG4105KZM cytoplasmic protein HV042_RS13640 ENOG4108V4B ThiJ pfpI HV042_RS13660 ENOG410642W LysR family Transcriptional regulator HV042_RS13685 ENOG4105Z2P Protein of unknown function (DUF465) HV042_RS13710 ENOG4106ETB IIa component HV042_RS13725 ENOG4108SU4 UPF0309 protein HV042_RS13730 ENOG41080U6 GntR family transcriptional regulator HV042_RS13765 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV042_RS13770 ENOG4105CJP fad dependent oxidoreductase HV042_RS13785 ENOG4106PG1 outer membrane usher protein HV042_RS13790 ENOG4106P2F Pfam:Pili_assembly_C HV042_RS13800 ENOG4105US4 fimbrial-like protein yfcP HV042_RS13805 ENOG4108FZ9 Chaperone HV042_RS13810 ENOG4105NEV Fimbrial HV042_RS13845 ENOG4106AFQ Histidine kinase HV042_RS13850 ENOG4108ZXC Two component transcriptional regulator, luxr family HV042_RS13855 ENOG4108NS2 receptor HV042_RS13860 ENOG4105D05 Receptor HV042_RS13870 ENOG4107PP3 Acetylornithine deacetylase HV042_RS13885 ENOG4105CNN ABC, transporter HV042_RS13890 ENOG4105C2J ABC transporter HV042_RS13895 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS13930 ENOG4109066 lysm domain bon superfamily protein HV042_RS13935 ENOG4107ZSV Receptor HV042_RS13940 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV042_RS13975 ENOG4105BZ1 (ABC) transporter HV042_RS13980 ENOG4105EYM Major Facilitator superfamily HV042_RS13995 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HV042_RS14005 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HV042_RS14010 ENOG4105C44 Serine transporter HV042_RS14015 ENOG4105EJQ L-serine dehydratase HV042_RS14025 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HV042_RS14030 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV042_RS14040 ENOG4107R0W ABC transporter HV042_RS14045 ENOG4105E5Q amino acid AbC transporter HV042_RS14050 ENOG4105CDA abc transporter atp-binding protein HV042_RS14060 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV042_RS14065 ENOG4105YA8 Transcriptional regulator HV042_RS14100 ENOG4107R0V Pyruvate dehydrogenase HV042_RS14105 ENOG4105CPP Dehydrogenase, E1 component HV042_RS14130 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV042_RS14135 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV042_RS14145 ENOG4105VPI YqaE family transport protein HV042_RS14150 ENOG4108WN0 inhibitor of vertebrate lysozyme HV042_RS14155 ENOG4106MMI NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV042_RS14160 ENOG4105BZU Histidine kinase HV042_RS14165 ENOG4105F32 YngK protein HV042_RS14180 ENOG4105BZS acriflavin resistance protein HV042_RS14205 ENOG41060NJ transcriptional regulator HV042_RS14210 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HV042_RS14215 ENOG4105CIB oxidoreductase Domain protein HV042_RS14220 ENOG4105ETU transcriptional activator (TenA HV042_RS14225 ENOG4108YI8 ABC transporter HV042_RS14230 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HV042_RS14235 ENOG4107Z6I Thiamine biosynthesis protein HV042_RS14240 ENOG4108JPW Aminotransferase HV042_RS14245 ENOG4105DY8 decarboxylase HV042_RS14260 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HV042_RS14275 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV042_RS14290 ENOG4105D7T ABC transporter HV042_RS14315 ENOG4105E82 cytochrome subunit of dehydrogenase HV042_RS14330 ENOG4105CBN LysR family transcriptional regulator HV042_RS14335 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HV042_RS14345 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HV042_RS14350 ENOG4105KT7 mgtC SapB transporter HV042_RS14360 ENOG4107TE1 transport protein HV042_RS14375 ENOG4107RSM transcriptional regulator HV042_RS14385 ENOG4108NIW Leucine export protein LeuE HV042_RS14390 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HV042_RS14395 ENOG4105FFC UPF0187 protein HV042_RS14410 ENOG4108Z9K Osmotically inducible protein HV042_RS14420 ENOG4105EJC lysr family transcriptional regulator HV042_RS14445 ENOG4105F2I Transposase HV042_RS14460 ENOG4105C5H ABC transporter HV042_RS14495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV042_RS14515 ENOG4105F27 Major Facilitator HV042_RS14525 ENOG4108MG3 formate dehydrogenase HV042_RS14530 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV042_RS14540 ENOG4105RPH Inner membrane protein YddG HV042_RS14555 ENOG4108UKV benzoate 1,2-dioxygenase HV042_RS14565 ENOG410626B catechol 1,2-dioxygenase HV042_RS14570 ENOG4105NN7 muconolactone delta-isomerase HV042_RS14575 ENOG4105DTQ mandelate racemase muconate lactonizing HV042_RS14580 ENOG4107HP6 Transcriptional regulator HV042_RS14595 ENOG4107QND Nitrite extrusion protein HV042_RS14600 ENOG4105CRU nitrate reductase, alpha subunit HV042_RS14605 ENOG4108IUE nitrate reductase beta subunit HV042_RS14610 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HV042_RS14615 ENOG4105D0D Nitrate reductase 2, gamma subunit HV042_RS14620 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV042_RS14625 ENOG4107RCV ABC transporter, permease HV042_RS14630 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HV042_RS14635 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV042_RS14640 ENOG4108MEJ flavin reductase domain protein HV042_RS14645 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV042_RS14655 ENOG4105CT4 transporter HV042_RS14665 ENOG4105F2I Transposase HV042_RS14685 ENOG4108N27 Glutathione S-transferase HV042_RS14690 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS14695 ENOG4105DIA mandelate racemase muconate lactonizing HV042_RS14710 ENOG4105CDA abc transporter atp-binding protein HV042_RS14735 ENOG4105DEN Luciferase family HV042_RS14745 ENOG4105C85 amino acid HV042_RS14750 ENOG4105SUV lipoprotein YgdR HV042_RS14755 ENOG4108NS2 receptor HV042_RS14760 ENOG4105CHB tonB-dependent Receptor HV042_RS14765 ENOG41065TG regulatoR HV042_RS14775 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV042_RS14785 ENOG4108Z7F N-acetyltransferase HV042_RS14790 ENOG4108T9Y Inner membrane protein ydcZ HV042_RS14795 ENOG4105R71 cytoplasmic protein HV042_RS14800 ENOG4105DEF Extracellular solute-binding protein, family 5 HV042_RS14810 ENOG4105NBR Pectinesterase HV042_RS14815 ENOG4105EBM Alpha Beta Hydrolase Fold protein HV042_RS14820 ENOG410654E Membrane HV042_RS14840 ENOG4105C26 Dehydrogenase HV042_RS14845 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HV042_RS14850 ENOG4105D81 ABC transporter, permease HV042_RS14855 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV042_RS14860 ENOG4107TYH extracellular solute-binding protein family 1 HV042_RS14865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV042_RS14870 ENOG4105C4M (Ubiquinol oxidase) subunit I HV042_RS14875 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV042_RS14890 ENOG4105CFP Peptidase U32 HV042_RS14895 ENOG4108JCI Transcriptional regulator HV042_RS14905 ENOG4105DKK Benzoate HV042_RS14910 ENOG4105UEI Transcriptional Regulator AraC Family HV042_RS14920 ENOG4108KKZ (LipO)protein HV042_RS14925 ENOG4105DEF Extracellular solute-binding protein, family 5 HV042_RS14930 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV042_RS14935 ENOG41088CC tellurite resistance protein tehB HV042_RS14940 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HV042_RS14945 ENOG4107WE3 acetyltransferase YdcK HV042_RS14950 ENOG4108Z9I -acetyltransferase HV042_RS14960 ENOG4105CHJ isochorismatase hydrolase HV042_RS14965 ENOG4105EBR Carboxylesterase HV042_RS14970 ENOG4105E32 cytoplasmic protein HV042_RS14975 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HV042_RS14980 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HV042_RS14985 ENOG4105DDW LysR family Transcriptional regulator HV042_RS15010 ENOG4105CPW cytochrome b561 HV042_RS15015 ENOG4105Y50 Virulence Protein HV042_RS15030 ENOG41061EV selenium-binding protein YdfZ HV042_RS15035 ENOG4105BZU Histidine kinase HV042_RS15040 ENOG4105W8I Transcriptional regulator HV042_RS15045 ENOG4105KD7 acetyltransferase HV042_RS15050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV042_RS15055 ENOG4105C26 Dehydrogenase HV042_RS15060 ENOG4107DB1 DUF218 domain HV042_RS15065 ENOG4105D82 Glutamate dehydrogenase HV042_RS15110 ENOG4105CQ7 ATP-dependent helicase HV042_RS15115 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HV042_RS15125 ENOG4108Z0R Transferase HV042_RS15130 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HV042_RS15135 ENOG4105DZS Phenylacetate-CoA ligase HV042_RS15140 ENOG4105CHU acetyl-coa acetyltransferase HV042_RS15145 ENOG4108ZJI phenylacetic acid degradation protein HV042_RS15150 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV042_RS15155 ENOG4108UKI Enoyl-CoA hydratase HV042_RS15160 ENOG4105E39 Enoyl-CoA hydratase HV042_RS15165 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV042_RS15170 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HV042_RS15175 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HV042_RS15180 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HV042_RS15185 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HV042_RS15190 ENOG4105DXM phenylacetic acid degradation protein HV042_RS15195 ENOG4105F11 amine oxidase HV042_RS15205 ENOG4105XDF Protein of unknown function (DUF1272) HV042_RS15210 ENOG4105GZI Transcriptional regulator HV042_RS15215 ENOG4108K3A Glutathione S-transferase HV042_RS15225 ENOG4105KVH Transcriptional regulator HV042_RS15235 ENOG4105CVJ phosphoglycerate mutase HV042_RS15240 ENOG41085W3 Transposase HV042_RS15250 ENOG4105HEI LysR family (Transcriptional regulator HV042_RS15255 ENOG4107RSM transcriptional regulator HV042_RS15275 ENOG4105F2I Transposase HV042_RS15280 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV042_RS15285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV042_RS15320 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV042_RS15325 ENOG4105UEI Transcriptional Regulator AraC Family HV042_RS15330 ENOG4105R1U AraC Family Transcriptional Regulator HV042_RS15335 ENOG4105DSW Fusaric acid resistance protein HV042_RS15345 ENOG4105Y49 secretion protein, HlyD family HV042_RS15370 ENOG4105KME endoribonuclease L-psp HV042_RS15375 ENOG4105H3G oxidoreductase HV042_RS15380 ENOG4107R11 Transcriptional regulator HV042_RS15390 ENOG4105EV8 ectoine hydroxylase HV042_RS15400 ENOG4105MP9 class II Aldolase HV042_RS15405 ENOG4105C26 Dehydrogenase HV042_RS15410 ENOG4108WFR AraC Family Transcriptional Regulator HV042_RS15415 ENOG4105WXT Conserved Protein HV042_RS15420 ENOG410689M (LipO)protein HV042_RS15425 ENOG4107H52 Dicarboxylate transport HV042_RS15435 ENOG4105C5I Dehydrogenase HV042_RS15440 ENOG41090X5 Heat shock protein hslJ HV042_RS15445 ENOG4105IKK cytoplasmic protein HV042_RS15490 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV042_RS15495 ENOG4105FCK Membrane HV042_RS15505 ENOG4108RW8 Universal stress protein F HV042_RS15515 ENOG4105C1J atp-dependent rna helicase HV042_RS15525 ENOG4108C33 Resolvase HV042_RS15575 ENOG4105CAR Terminase, large subunit HV042_RS15655 ENOG4107R08 Integrase HV042_RS15665 ENOG4105MVE transcriptional regulator HV042_RS15670 ENOG4105D9R oxidoreductase HV042_RS15675 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV042_RS15680 ENOG4105KT5 UmuD protein HV042_RS15700 ENOG4105R3P Inner membrane protein yagU HV042_RS15710 ENOG4108PNB DNA-binding transcriptional regulator HV042_RS15720 ENOG4105CBN LysR family transcriptional regulator HV042_RS15735 ENOG4105CBN LysR family transcriptional regulator HV042_RS15740 ENOG4105EQ2 LysR family Transcriptional regulator HV042_RS15745 ENOG4105ENX hydrolase HV042_RS15750 ENOG4107RTG Major Facilitator superfamily HV042_RS15760 ENOG4108XDN Transcriptional regulator HV042_RS15770 ENOG4107FW0 short-chain dehydrogenase reductase HV042_RS15785 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV042_RS15805 ENOG4107SEY Conserved Protein HV042_RS15810 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HV042_RS15820 ENOG4105CT4 transporter HV042_RS15825 ENOG4105DSG hydrolase family 43 HV042_RS15840 ENOG4108Z0Z intracellular protease Pfpi family HV042_RS15845 ENOG4107QSI ABC, transporter HV042_RS15850 ENOG4105KXI murein peptide amidase A HV042_RS15855 ENOG4107S8C mandelate racemase muconate lactonizing HV042_RS15860 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV042_RS15865 ENOG4108KK1 membrane protein AbrB duplication HV042_RS15870 ENOG4108JU8 Transcriptional regulator HV042_RS15880 ENOG4105CM6 amino acid regulated cytosolic protein HV042_RS15885 ENOG4105K8Z Phage shock protein HV042_RS15890 ENOG4105NNG Peripheral inner membrane phage-shock protein HV042_RS15895 ENOG4105FM1 phage shock protein C HV042_RS15900 ENOG4105YYT phage shock protein B HV042_RS15905 ENOG41087YS Phage shock protein A HV042_RS15910 ENOG4105E51 psp operon transcriptional activator HV042_RS15920 ENOG4105CH2 amidohydrolase HV042_RS15935 ENOG4108HIY periplasmic HV042_RS15940 ENOG4108EKA peptide transport system, permease HV042_RS15945 ENOG4108EU3 peptide transport system, permease HV042_RS15950 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV042_RS15955 ENOG4108JQ2 peptide transport system atp-binding protein HV042_RS15960 ENOG41090B9 response to stress HV042_RS15965 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV042_RS15970 ENOG4105Q4T oxidoreductase HV042_RS15975 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HV042_RS15985 ENOG4105N2W Transcriptional regulator HV042_RS15990 ENOG41061RM osmotically inducible lipoprotein HV042_RS15995 ENOG4108ZJT translation initiation factor, Sui1 HV042_RS16005 ENOG4105CFV Tetratricopeptide repeat protein HV042_RS16010 ENOG4105Q4A inner membrane protein yciS HV042_RS16015 ENOG4105EYK Phosphatidylglycerophosphatase B HV042_RS16020 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HV042_RS16025 ENOG4107QM5 aconitate hydratase HV042_RS16035 ENOG4107R11 Transcriptional regulator HV042_RS16040 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV042_RS16045 ENOG4105RKX Protein of unknown function (DUF2498) HV042_RS16050 ENOG4105ERU peptidase HV042_RS16055 ENOG4105UBK short-chain dehydrogenase reductase HV042_RS16060 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV042_RS16075 ENOG4105CT4 transporter HV042_RS16080 ENOG4105FE9 pseudouridine synthase HV042_RS16095 ENOG4105EG3 transmembrane signal peptide protein HV042_RS16100 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV042_RS16105 ENOG4105DB7 PHP domain protein HV042_RS16110 ENOG4105CRQ synthase (Component I) HV042_RS16115 ENOG4108EFP Anthranilate synthase component II HV042_RS16120 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV042_RS16130 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HV042_RS16140 ENOG4105CPQ Dehydrogenase HV042_RS16155 ENOG4105N0E Protein of unknown function (DUF2543) HV042_RS16165 ENOG4108C33 Resolvase HV042_RS16250 ENOG4105TKZ Tail Sheath HV042_RS16330 ENOG4105F2I Transposase HV042_RS16340 ENOG4105NVB glycoside hydrolase, family 19 HV042_RS16360 ENOG4108MXB Protein of unknown function (DUF968) HV042_RS16365 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HV042_RS16430 ENOG41087BU transcriptional repressor DicA HV042_RS16440 ENOG4105UVW uncharacterized protein yebW HV042_RS16450 ENOG41076J9 exonuclease VIII HV042_RS16460 ENOG4108I1J Integrase HV042_RS16465 ENOG4105EIF outer membrane protein W HV042_RS16475 ENOG4107835 probably involved in intracellular septation (By similarity) HV042_RS16480 ENOG4107RNH Outer membrane receptor FepA HV042_RS16485 ENOG4105NAU thioesterase Superfamily protein HV042_RS16490 ENOG4107PN8 YfeABCD locus regulator HV042_RS16495 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV042_RS16500 ENOG4105CHR reductase HV042_RS16505 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV042_RS16510 ENOG4108ETY sodium dicarboxylate symporter HV042_RS16515 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HV042_RS16520 ENOG4105CH6 catalase HV042_RS16525 ENOG410901P UPF0249 protein HV042_RS16530 ENOG4105F8D glycoside hydrolase family 4 HV042_RS16540 ENOG4105F2I Transposase HV042_RS16550 ENOG4105KKI DNA-binding transcriptional activator OsmE HV042_RS16560 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV042_RS16565 ENOG4105EG3 transmembrane signal peptide protein HV042_RS16570 ENOG4108V0P LemA family HV042_RS16575 ENOG4108SPG Periplasmic Protein HV042_RS16585 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HV042_RS16590 ENOG4105C26 Dehydrogenase HV042_RS16595 ENOG4105F4X arginine HV042_RS16605 ENOG4105CGK Exodeoxyribonuclease III HV042_RS16610 ENOG4108RSN SNARE associated Golgi HV042_RS16615 ENOG4108N5C SNARE associated Golgi protein-related protein HV042_RS16620 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV042_RS16625 ENOG4105VNH ABC transporter solute-binding protein HV042_RS16630 ENOG4105CXZ ABC transporter, permease HV042_RS16635 ENOG4108VGW abc transporter atp-binding protein HV042_RS16640 ENOG4107RM6 sulfurtransferase HV042_RS16645 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV042_RS16650 ENOG4105M6F mutator MutT protein HV042_RS16655 ENOG4105D82 Glutamate dehydrogenase HV042_RS16660 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV042_RS16665 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HV042_RS16670 ENOG4105SBG acid phosphatase HV042_RS16675 ENOG41069NU Nitroreductase HV042_RS16680 ENOG4105D07 Signal peptide peptidase, SppA HV042_RS16685 ENOG4105HDK L-asparaginase HV042_RS16690 ENOG4108RWI nicotinamidase HV042_RS16695 ENOG4108KUU Inner membrane metabolite transport protein ydjE HV042_RS16700 ENOG4105E98 transcriptional regulator DeoR family HV042_RS16705 ENOG4105CPC Aldo Keto reductase HV042_RS16710 ENOG4107UH8 sugar kinase HV042_RS16715 ENOG4105D2N Aldolase HV042_RS16720 ENOG4105CPQ Dehydrogenase HV042_RS16725 ENOG4107TE1 transport protein HV042_RS16730 ENOG4105CPQ Dehydrogenase HV042_RS16740 ENOG4105N1F Hnh endonuclease HV042_RS16745 ENOG4105VUT cytoplasmic protein HV042_RS16755 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV042_RS16760 ENOG4105DSB aldose 1-epimerase HV042_RS16765 ENOG4105CV8 reductase HV042_RS16770 ENOG4105GNX MltA-interacting MipA family protein HV042_RS16775 ENOG4105CYN Serine protein kinase HV042_RS16785 ENOG4108XNZ glycosyl transferase HV042_RS16790 ENOG4108KHP Diguanylate cyclase HV042_RS16795 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV042_RS16800 ENOG4108VMM UPF0756 membrane protein HV042_RS16805 ENOG4105R1U AraC Family Transcriptional Regulator HV042_RS16810 ENOG4105DJ2 Major Facilitator Superfamily HV042_RS16815 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV042_RS16820 ENOG4105EWC Purine nucleoside phosphorylase HV042_RS16825 ENOG4105K78 MarR family Transcriptional regulator HV042_RS16830 ENOG4105UCG Domain of unknown function (DUF333) HV042_RS16835 ENOG4105ZTC transcriptional activator, Ogr delta HV042_RS16965 ENOG4105ED4 portal protein HV042_RS16990 ENOG4105VZ1 Replication Protein HV042_RS17035 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV042_RS17040 ENOG410620I Diguanylate cyclase HV042_RS17045 ENOG4106G4W HV042_RS17060 ENOG4105S5I Membrane HV042_RS17065 ENOG4108NIW Leucine export protein LeuE HV042_RS17070 ENOG4105D1S lipid A biosynthesis HV042_RS17075 ENOG4108SF5 RNA Polymerase HV042_RS17080 ENOG4108S3W Anti-feci sigma factor, fecr HV042_RS17085 ENOG4105GAV receptor HV042_RS17090 ENOG4108HUF Transporter HV042_RS17095 ENOG4105DQ5 transport system permease protein HV042_RS17100 ENOG4108IHU transport system permease protein HV042_RS17105 ENOG4105E0A ABC, transporter HV042_RS17115 ENOG4105DHT Metal Dependent Phosphohydrolase HV042_RS17120 ENOG4106TD9 Diguanylate cyclase HV042_RS17125 ENOG4107NQ8 LysR family Transcriptional regulator HV042_RS17140 ENOG4108HMX isocitrate dehydrogenase (NADP) HV042_RS17145 ENOG4108R99 pseudouridine synthase HV042_RS17160 ENOG41075W9 High frequency lysogenization protein HflD homolog HV042_RS17165 ENOG4107QTF adenylosuccinate lyase HV042_RS17190 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV042_RS17195 ENOG4105IFJ Histidine kinase HV042_RS17200 ENOG4105EZE Cupin 4 family protein HV042_RS17220 ENOG4105D38 putrescine abc transporter HV042_RS17225 ENOG4108HM4 ABC transporter HV042_RS17235 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV042_RS17240 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HV042_RS17245 ENOG4105D60 lipoprotein releasing system transmembrane protein HV042_RS17250 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV042_RS17255 ENOG4105D60 lipoprotein releasing system transmembrane protein HV042_RS17260 ENOG4108JA2 transcriptioN-repair coupling factor HV042_RS17265 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV042_RS17270 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV042_RS17280 ENOG4108IND Tetr family transcriptional regulator HV042_RS17290 ENOG4107MBR 17 kDa surface antigen HV042_RS17295 ENOG4105CEP NADH dehydrogenase HV042_RS17300 ENOG4105D0Y UPF0227 protein HV042_RS17315 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV042_RS17320 ENOG41090DQ Lipoprotein HV042_RS17325 ENOG4105K59 histidine triad (HIT) protein HV042_RS17330 ENOG4105CNM Receptor HV042_RS17335 ENOG4105CI1 PTS System HV042_RS17340 ENOG4105F8V Hydrolase, tatD family HV042_RS17345 ENOG4107QRG dna polymerase iii HV042_RS17350 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HV042_RS17355 ENOG4105HHA aminodeoxychorismate lyase HV042_RS17360 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV042_RS17365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV042_RS17370 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV042_RS17375 ENOG4105CHR reductase HV042_RS17380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV042_RS17385 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV042_RS17390 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HV042_RS17395 ENOG4105VGS 50s ribosomal protein l32 HV042_RS17400 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV042_RS17405 ENOG4108UHJ MAF-like protein HV042_RS17415 ENOG4105EI2 Pseudouridine synthase HV042_RS17420 ENOG4107QQB Ribonuclease E HV042_RS17425 ENOG4105EJC lysr family transcriptional regulator HV042_RS17430 ENOG4105EQ0 Major Facilitator superfamily HV042_RS17435 ENOG4105CJR Integral membrane protein (MviN HV042_RS17440 ENOG4105EP9 oxidoreductase HV042_RS17450 ENOG4105D9U N-acetyltransferase HV042_RS17460 ENOG4105E9S glutaredoxin 2 HV042_RS17465 ENOG4105F3T (LipO)protein HV042_RS17470 ENOG4105EKE dihydroorotase HV042_RS17475 ENOG4105MEA DNA damage-inducible protein i HV042_RS17480 ENOG4105F2I Transposase HV042_RS17485 ENOG4105PVA Biofilm formation regulatory protein BssS HV042_RS17495 ENOG4106974 biofilm formation HV042_RS17505 ENOG4105D1S lipid A biosynthesis HV042_RS17515 ENOG4108W47 Acidic protein msyB HV042_RS17520 ENOG4105NAC (LipO)protein HV042_RS17555 ENOG4108UQ5 membrane protein YcdZ HV042_RS17560 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV042_RS17580 ENOG4105HEI LysR family (Transcriptional regulator HV042_RS17585 ENOG4105EUB pirin domain protein HV042_RS17590 ENOG4105CHJ isochorismatase hydrolase HV042_RS17610 ENOG41062D9 Histidine kinase HV042_RS17630 ENOG4105D5M phosphate starvation-inducible protein HV042_RS17635 ENOG4105DBE peroxidase HV042_RS17640 ENOG410650H (LipO)protein HV042_RS17645 ENOG4105EKT )-iron permease HV042_RS17650 ENOG4105D9N nucleoside HV042_RS17660 ENOG4105CK7 Sodium proline symporter HV042_RS17665 ENOG4105C26 Dehydrogenase HV042_RS17675 ENOG4108R86 Transcriptional regulator HV042_RS17710 ENOG4105C2W permease HV042_RS17715 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV042_RS17725 ENOG4105XH3 HV042_RS17730 ENOG4105D6F Phosphatase HV042_RS17745 ENOG4105CUB amino acid HV042_RS17750 ENOG4105CFQ glutamine synthetase HV042_RS17755 ENOG4108Z86 Glutamine amidotransferase HV042_RS17760 ENOG4107VRI Transcriptional regulator HV042_RS17765 ENOG4105C26 Dehydrogenase HV042_RS17770 ENOG4105CJP fad dependent oxidoreductase HV042_RS17775 ENOG4105EJC lysr family transcriptional regulator HV042_RS17780 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV042_RS17785 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV042_RS17790 ENOG4105DM4 PTS System HV042_RS17795 ENOG4108YRF PTS System HV042_RS17805 ENOG4108AHH pyruvate formate lyase II activase HV042_RS17810 ENOG4108XCZ PTS System HV042_RS17820 ENOG4106R3P AraC family transcriptional regulator HV042_RS17825 ENOG4105BZU Histidine kinase HV042_RS17845 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV042_RS17855 ENOG4108PU9 oligogalacturonate-specific porin HV042_RS17860 ENOG41061NF Pectate lyase HV042_RS17870 ENOG4105C5R Aminotransferase HV042_RS17880 ENOG4105E5Q amino acid AbC transporter HV042_RS17900 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV042_RS17935 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HV042_RS17940 ENOG4107QUY Guanine deaminase HV042_RS17945 ENOG4105VT2 5-hydroxyisourate hydrolase HV042_RS17955 ENOG4105C2W permease HV042_RS17960 ENOG41061H0 Monooxygenase HV042_RS18000 ENOG41064T2 transcriptional regulator, lysR family HV042_RS18010 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV042_RS18020 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV042_RS18030 ENOG4108M8W Monooxygenase HV042_RS18035 ENOG4105KME endoribonuclease L-psp HV042_RS18040 ENOG4105VEQ Cold shock protein HV042_RS18045 ENOG4105VEQ Cold shock protein HV042_RS18065 ENOG4105E5Q amino acid AbC transporter HV042_RS18070 ENOG4105CDA abc transporter atp-binding protein HV042_RS18075 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV042_RS18080 ENOG41060BG Tetr family transcriptional regulator HV042_RS18115 ENOG4105E7U AraC family transcriptional regulator HV042_RS18125 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV042_RS18130 ENOG4105SUT Transcriptional Regulator AraC Family HV042_RS18140 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV042_RS18145 ENOG4105CHR reductase HV042_RS18155 ENOG4107R0W ABC transporter HV042_RS18160 ENOG4105E5Q amino acid AbC transporter HV042_RS18165 ENOG4105CDA abc transporter atp-binding protein HV042_RS18170 ENOG4107PP3 Acetylornithine deacetylase HV042_RS18185 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS18200 ENOG4105FDP GntR family transcriptional regulator HV042_RS18210 ENOG4105ETZ PTS System HV042_RS18215 ENOG4105F3R pts system mannose fructose sorbose family iid HV042_RS18220 ENOG4108IQ3 PTS system HV042_RS18225 ENOG4108SU4 UPF0309 protein HV042_RS18230 ENOG4105EP8 Glycosyl Hydrolase Family 88 HV042_RS18235 ENOG4108SU4 UPF0309 protein HV042_RS18240 ENOG4105EPF Outer membrane porin HV042_RS18270 ENOG4108C33 Resolvase HV042_RS18360 ENOG4105IM0 capsid protein HV042_RS18370 ENOG4105D07 Signal peptide peptidase, SppA HV042_RS18380 ENOG4107DE1 head-to-tail joining protein HV042_RS18385 ENOG4105UZW Tail fiber assembly protein HV042_RS18390 ENOG4105FKG DNA packaging protein HV042_RS18435 ENOG4108MXB Protein of unknown function (DUF968) HV042_RS18440 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HV042_RS18490 ENOG4105JBR DNA replication protein HV042_RS18495 ENOG4105ZTP Protein of unknown function (DUF1376) HV042_RS18520 ENOG4105UVW uncharacterized protein yebW HV042_RS18530 ENOG41076J9 exonuclease VIII HV042_RS18550 ENOG4107QSI ABC, transporter HV042_RS18555 ENOG4108MN8 Membrane HV042_RS18565 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV042_RS18570 ENOG4108UQN AraC family transcriptional regulator HV042_RS18575 ENOG4108V1U phospholipid-binding protein HV042_RS18585 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HV042_RS18595 ENOG4107TYR Glycosyl Transferase HV042_RS18605 ENOG4108JJA ABC, transporter HV042_RS18630 ENOG4105K4P CoA-binding domain protein HV042_RS18640 ENOG41088T4 Helicase IV HV042_RS18645 ENOG410901E Membrane HV042_RS18650 ENOG4105EM2 membrane HV042_RS18655 ENOG4108RZ1 DNA transformation protein HV042_RS18660 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HV042_RS18665 ENOG4105UYK outer membrane protein a HV042_RS18670 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HV042_RS18675 ENOG4105DAN ATP-dependent protease HV042_RS18685 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV042_RS18690 ENOG4108Q2G (LipO)protein HV042_RS18695 ENOG4105DY2 Paraquat-inducible protein b HV042_RS18700 ENOG4105F1S paraquat-inducible protein a HV042_RS18705 ENOG4105C5H ABC transporter HV042_RS18710 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HV042_RS18715 ENOG4105QVC MOSC domain-containing protein HV042_RS18720 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV042_RS18730 ENOG4108UZX fmn reductase HV042_RS18735 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV042_RS18745 ENOG4105CD8 aminopeptidase N HV042_RS18755 ENOG4105C5S asparaginyl-tRNA synthetase HV042_RS18760 ENOG4105ZIT Porin Gram-negative type HV042_RS18765 ENOG4105CGF Aromatic amino acid aminotransferase HV042_RS18770 ENOG4105C5X domain protein HV042_RS18775 ENOG4105EAQ (twin-arginine translocation) pathway signal HV042_RS18780 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV042_RS18790 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV042_RS18795 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HV042_RS18800 ENOG4106371 Methyltransferase HV042_RS18805 ENOG4107S90 membrAne HV042_RS18810 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV042_RS18820 ENOG4105W49 UPF0434 protein HV042_RS18825 ENOG4105T0Z Conserved Protein HV042_RS18830 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HV042_RS18835 ENOG4105BZ1 (ABC) transporter HV042_RS18840 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV042_RS18850 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV042_RS18855 ENOG4105CAT Cytidine monophosphate kinase HV042_RS18860 ENOG4108K0D peptidase, M48 HV042_RS18865 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HV042_RS18870 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HV042_RS18875 ENOG4107VMU Membrane HV042_RS18880 ENOG4105DDY UPF0142 protein ycaO HV042_RS18885 ENOG4105TMB Formate nitrite transporter HV042_RS18890 ENOG4105C6N Formate acetyltransferase HV042_RS18895 ENOG4105F1A Pyruvate formate-lyase HV042_RS18900 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV042_RS18915 ENOG4108HHA Transketolase HV042_RS18920 ENOG4108IUS Transketolase HV042_RS18925 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV042_RS18930 ENOG4108ISG Major Facilitator HV042_RS18935 ENOG4107KGK dmso reductase anchor subunit HV042_RS18940 ENOG4105QAX Iron-sulfur HV042_RS18945 ENOG4107QY8 reductase HV042_RS18950 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HV042_RS18955 ENOG4105D1H recombination factor protein RarA HV042_RS18965 ENOG4105CNU cell division protein FtsK HV042_RS18970 ENOG4105EW9 transcriptional regulator AsnC family HV042_RS18975 ENOG4105C3M thioredoxin reductase HV042_RS18980 ENOG4108JJ9 ABC, transporter HV042_RS18985 ENOG4108JJ8 (ABC) transporter HV042_RS19000 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV042_RS19005 ENOG4105F2I Transposase HV042_RS19010 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HV042_RS19015 ENOG4105VEQ Cold shock protein HV042_RS19025 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV042_RS19030 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV042_RS19035 ENOG4105F2I Transposase HV042_RS19040 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV042_RS19045 ENOG4105DWU Membrane HV042_RS19055 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV042_RS19065 ENOG4105C7K acetolactate synthase HV042_RS19070 ENOG4105C5W Aldolase HV042_RS19075 ENOG4105CGD Nad-dependent epimerase dehydratase HV042_RS19080 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV042_RS19085 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV042_RS19090 ENOG4105K8R UPF0145 protein HV042_RS19095 ENOG41064MM (LipO)protein HV042_RS19100 ENOG4105E5Z arginine transporter ATP-binding subunit HV042_RS19105 ENOG4106PMH Extracellular solute-binding protein family 3 HV042_RS19110 ENOG4105GBT ABC transporter HV042_RS19115 ENOG4105DMR ABC, transporter HV042_RS19120 ENOG4106TNF Periplasmic binding protein HV042_RS19130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV042_RS19135 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HV042_RS19140 ENOG4105RBQ inner membrane protein ybjO HV042_RS19145 ENOG4105D38 putrescine abc transporter HV042_RS19150 ENOG4105F38 ABC transporter, permease HV042_RS19155 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV042_RS19160 ENOG4107RUE extracellular solute-binding protein family 1 HV042_RS19165 ENOG4108RMJ sensory transduction regulator HV042_RS19175 ENOG4108DBC nitroreductase HV042_RS19180 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HV042_RS19185 ENOG41090BQ Glutaredoxin HV042_RS19190 ENOG4105GWF inner membrane protein YbjM HV042_RS19200 ENOG4108RFG Tetr family transcriptional regulator HV042_RS19205 ENOG4106UW1 Major Facilitator superfamily HV042_RS19210 ENOG4108HCJ Hydrolase HV042_RS19215 ENOG4107QF7 multi-drug HV042_RS19220 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV042_RS19225 ENOG4107FB0 transcriptional regulator DeoR family HV042_RS19230 ENOG4105DZ1 carboxypeptidase HV042_RS19235 ENOG4108TGY Glutathione S-transferase HV042_RS19240 ENOG4105D8V Glucose sorbosone dehydrogenase HV042_RS19245 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV042_RS19250 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV042_RS19270 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV042_RS19275 ENOG4105DEF Extracellular solute-binding protein, family 5 HV042_RS19280 ENOG4108JQ6 ABC transporter HV042_RS19285 ENOG4105D44 asparaginase HV042_RS19290 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV042_RS19295 ENOG4105D06 uba thif-type nad fad binding protein HV042_RS19300 ENOG4105F1A Pyruvate formate-lyase HV042_RS19310 ENOG4108HCJ Hydrolase HV042_RS19315 ENOG41072TH Protein of unknown function (DUF1479) HV042_RS19320 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS19325 ENOG4105DPW Major facilitator superfamily MFS_1 HV042_RS19335 ENOG4105C5H ABC transporter HV042_RS19345 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV042_RS19350 ENOG4108TZY GntR Family Transcriptional Regulator HV042_RS19355 ENOG4105CS2 ec 3.2.1.21 HV042_RS19360 ENOG4105CPC Aldo Keto reductase HV042_RS19365 ENOG4105F4P )-transporter HV042_RS19370 ENOG4105KST dependent repressor HV042_RS19380 ENOG4108I6E Sulfatase HV042_RS19385 ENOG4108T1M outer membrane protein x HV042_RS19395 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HV042_RS19400 ENOG4107R0W ABC transporter HV042_RS19405 ENOG4105E5Q amino acid AbC transporter HV042_RS19410 ENOG4105CDA abc transporter atp-binding protein HV042_RS19415 ENOG4105D8X mechanosensitive ion channel HV042_RS19420 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HV042_RS19430 ENOG4108IU3 tonb-dependent siderophore receptor HV042_RS19440 ENOG4105KSC Transcriptional regulator, TraR DksA family HV042_RS19445 ENOG4105VR4 UPF0379 protein ybiJ HV042_RS19450 ENOG4108MTB glycosyl transferase family HV042_RS19455 ENOG4105DVT helicase HV042_RS19460 ENOG4105C1J atp-dependent rna helicase HV042_RS19480 ENOG4105DJB Major Facilitator Superfamily HV042_RS19485 ENOG4108PZW LysR family Transcriptional regulator HV042_RS19490 ENOG4107MVR Transcriptional regulator HV042_RS19495 ENOG4105D0S secretion protein (HlyD HV042_RS19500 ENOG4105CJ1 ABC, transporter HV042_RS19505 ENOG4107QWP ABC-2 type transporter HV042_RS19510 ENOG4107QWP ABC-2 type transporter HV042_RS19515 ENOG4105I9U inner membrane protein ybhQ HV042_RS19520 ENOG4105X23 Endonuclease Exonuclease phosphatase HV042_RS19525 ENOG4105DZQ phospholipase D Transphosphatidylase HV042_RS19530 ENOG4107UXM Membrane HV042_RS19535 ENOG4105HFZ Membrane HV042_RS19540 ENOG4108ZAF Molybdopterin HV042_RS19545 ENOG4105M00 molybdopterin converting factor, subunit 1 HV042_RS19550 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HV042_RS19555 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV042_RS19560 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HV042_RS19565 ENOG4105CHW UPF0052 protein HV042_RS19570 ENOG4105DIJ Phosphoethanolamine transferase HV042_RS19575 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV042_RS19580 ENOG4105ECM Sensor protein basS pmrB HV042_RS19590 ENOG4108IV0 ABC, transporter HV042_RS19600 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV042_RS19615 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV042_RS19620 ENOG4108V1U phospholipid-binding protein HV042_RS19625 ENOG4105C85 amino acid HV042_RS19650 ENOG41088SP formiminoglutamate hydrolase HV042_RS19660 ENOG4105NBR Pectinesterase HV042_RS19675 ENOG4108XDN Transcriptional regulator HV042_RS19680 ENOG4105BZU Histidine kinase HV042_RS19685 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV042_RS19700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV042_RS19715 ENOG4108K4B hydrolase HV042_RS19720 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HV042_RS19725 ENOG4105E0C molybdate abc transporter HV042_RS19730 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV042_RS19740 ENOG4105F4R Transcriptional regulator mode HV042_RS19745 ENOG4105DKW ABC transporter HV042_RS19750 ENOG4105CMR udp-glucose 4-epimerase HV042_RS19755 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV042_RS19760 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HV042_RS19765 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV042_RS19770 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV042_RS19775 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV042_RS19780 ENOG4105JND homeobox protein HV042_RS19785 ENOG4105PGM cation diffusion facilitator family transporter HV042_RS19790 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV042_RS19795 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HV042_RS19830 ENOG4105UFD tol-pal system protein YbgF HV042_RS19835 ENOG4105KCK Peptidoglycan-associated lipoprotein HV042_RS19845 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV042_RS19845 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV042_RS19855 ENOG4105E02 MotA TolQ exbB proton channel HV042_RS19860 ENOG4107YD3 Thioesterase HV042_RS19865 ENOG4105KJB cyd operon protein YbgE HV042_RS19875 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV042_RS19880 ENOG4105C4M (Ubiquinol oxidase) subunit I HV042_RS19885 ENOG4105F2I Transposase HV042_RS19890 ENOG4107WFU Glutamate mutase subunit sigma HV042_RS19900 ENOG4105DJI Methylaspartate mutase, E subunit HV042_RS19920 ENOG4105CK2 sodium dicarboxylate symporter HV042_RS19925 ENOG4105CSV Glutaminase HV042_RS19930 ENOG4107GFK fumarate HV042_RS19935 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV042_RS19940 ENOG4105ETT transcriptional Regulator, LysR family HV042_RS19945 ENOG4107XVH Transcriptional regulator HV042_RS19950 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV042_RS19955 ENOG4105CMV Succinyl-CoA synthetase subunit beta HV042_RS19960 ENOG4105C7S Dehydrogenase HV042_RS19965 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV042_RS19970 ENOG4105E33 succinate dehydrogenase HV042_RS19975 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV042_RS19980 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV042_RS19985 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV042_RS19990 ENOG4105BZN citrate synthase HV042_RS20015 ENOG4105E7W lamb ycsf family protein HV042_RS20020 ENOG4107R7A Allophanate hydrolase subunit 2 HV042_RS20025 ENOG4105P4J Allophanate hydrolase, subunit 1 HV042_RS20030 ENOG4107QNR UPF0135 protein HV042_RS20040 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV042_RS20045 ENOG4105XIQ Protein of unknown function (DUF2517) HV042_RS20055 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HV042_RS20065 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HV042_RS20070 ENOG4105C08 Histidine kinase HV042_RS20075 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV042_RS20080 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV042_RS20085 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HV042_RS20090 ENOG4105CMG Carbohydrate kinase HV042_RS20095 ENOG4105CNN ABC, transporter HV042_RS20100 ENOG4105C2J ABC transporter HV042_RS20105 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV042_RS20110 ENOG4105CPQ Dehydrogenase HV042_RS20115 ENOG4105E98 transcriptional regulator DeoR family HV042_RS20125 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV042_RS20130 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV042_RS20135 ENOG4105EV9 Alpha Beta Hydrolase HV042_RS20140 ENOG4105NNH LexA regulated protein HV042_RS20145 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV042_RS20150 ENOG41090R7 Ferric uptake HV042_RS20155 ENOG4106P55 Transcriptional regulator HV042_RS20160 ENOG4107EFR Flavocytochrome c HV042_RS20175 ENOG4105GX6 (LipO)protein HV042_RS20185 ENOG4105CX6 glutaminyL-tRNA synthetase HV042_RS20190 ENOG4105CI1 PTS System HV042_RS20200 ENOG4105CE4 GlcNAc 6-P deacetylase HV042_RS20205 ENOG4105E2R ROK family HV042_RS20210 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV042_RS20215 ENOG4105F2I Transposase HV042_RS20235 ENOG4105CAQ asparagine synthetase HV042_RS20275 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV042_RS20280 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HV042_RS20285 ENOG4105C9A Phoh family HV042_RS20290 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HV042_RS20295 ENOG4108JU5 Magnesium and cobalt efflux protein HV042_RS20300 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV042_RS20305 ENOG4107RP9 extracellular solute-binding protein, family 3 HV042_RS20310 ENOG4105EAD ABC transporter HV042_RS20315 ENOG4105DRP amino acid AbC transporter HV042_RS20320 ENOG4105CDA abc transporter atp-binding protein HV042_RS20330 ENOG4105CKT filamentous hemagglutinin HV042_RS20335 ENOG4107PAI alpha helical protein HV042_RS20340 ENOG4105C8T Leucyl-tRNA synthetase HV042_RS20350 ENOG4105DJF DNA polymerase III, delta' subunit HV042_RS20355 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HV042_RS20360 ENOG4108TGR phosphatase HV042_RS20365 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV042_RS20370 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HV042_RS20375 ENOG4105CJN penicillin-binding protein HV042_RS20380 ENOG4105CNI cell division protein FtsW HV042_RS20385 ENOG4105K6T rare lipoprotein A HV042_RS20390 ENOG4105DZ1 carboxypeptidase HV042_RS20395 ENOG4108Z43 UPF0250 protein HV042_RS20405 ENOG41064T2 transcriptional regulator, lysR family HV042_RS20410 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HV042_RS20415 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV042_RS20435 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV042_RS20440 ENOG4105CEE C4-dicarboxylate transporter HV042_RS20445 ENOG4105KTS ribonuclease HV042_RS20450 ENOG4105NXH GreA GreB family elongation factor HV042_RS20455 ENOG4108U51 Universal stress protein HV042_RS20460 ENOG4108JU3 Alkyl hydroperoxide reductase HV042_RS20465 ENOG4105D3R alkyl hydroperoxide reductase HV042_RS20470 ENOG4105DQS Transcriptional regulator HV042_RS20475 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV042_RS20480 ENOG4105GTN ParB Domain Protein Nuclease HV042_RS20485 ENOG4105CHM Aminotransferase HV042_RS20490 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HV042_RS20495 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HV042_RS20510 ENOG4105C2J ABC transporter HV042_RS20515 ENOG4105CNN ABC, transporter HV042_RS20530 ENOG4108M3J Dehydrogenase HV042_RS20550 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV042_RS20560 ENOG4105DZC cytosine deaminase HV042_RS20565 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS20570 ENOG4105ECY inositol monophosphatase HV042_RS20575 ENOG4105CXY transporter HV042_RS20580 ENOG4105D6F Phosphatase HV042_RS20590 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HV042_RS20605 ENOG4105CNN ABC, transporter HV042_RS20610 ENOG4105C2J ABC transporter HV042_RS20615 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV042_RS20630 ENOG4105VCD cytoplasmic protein HV042_RS20635 ENOG4105D22 carbon starvation protein HV042_RS20640 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HV042_RS20645 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV042_RS20650 ENOG4105WQI isochorismatase HV042_RS20655 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV042_RS20660 ENOG4105E4F Isochorismate synthase HV042_RS20665 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV042_RS20670 ENOG4105E8G Major facilitator Superfamily HV042_RS20675 ENOG4105DQ5 transport system permease protein HV042_RS20680 ENOG4105TVJ transport system, permease HV042_RS20685 ENOG4105E0A ABC, transporter HV042_RS20690 ENOG4105C0W non-ribosomal peptide synthetase HV042_RS20695 ENOG41085A6 mbth domain-containing protein HV042_RS20700 ENOG4105E93 esterase HV042_RS20705 ENOG4107RNH Outer membrane receptor FepA HV042_RS20710 ENOG4108TSE Transferase HV042_RS20715 ENOG4108IUS Transketolase HV042_RS20720 ENOG4108HHA Transketolase HV042_RS20725 ENOG4105DKT Transcriptional regulator HV042_RS20730 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV042_RS20735 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV042_RS20745 ENOG4105C2J ABC transporter HV042_RS20750 ENOG4105CNN ABC, transporter HV042_RS20760 ENOG4108R85 Short chain dehydrogenase HV042_RS20765 ENOG4107635 Hok Gef family protein HV042_RS20770 ENOG4105C94 Transporter HV042_RS20795 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV042_RS20800 ENOG4105EMU Dehydrogenase HV042_RS20810 ENOG4105E5Q amino acid AbC transporter HV042_RS20815 ENOG4105DRP amino acid AbC transporter HV042_RS20830 ENOG410829K Lysine exporter protein (Lyse ygga) HV042_RS20835 ENOG4105CHM Aminotransferase HV042_RS20840 ENOG4105T38 integral membrane protein HV042_RS20845 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HV042_RS20850 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HV042_RS20855 ENOG4105C3U ABC transporter HV042_RS20865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV042_RS20875 ENOG4108J59 Extracellular solute-binding protein, family 5 HV042_RS20880 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HV042_RS20885 ENOG4108T58 Mg2 transport protein CorA HV042_RS20895 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV042_RS20905 ENOG4105WQ6 Membrane HV042_RS20915 ENOG4105E0K tonB-dependent siderophore receptor HV042_RS20920 ENOG4105HFT AraC family transcriptional regulator HV042_RS20930 ENOG410630P Transcriptional regulator HV042_RS20935 ENOG4105MSB protein, conserved in bacteria HV042_RS20940 ENOG4108RCM Nitroreductase HV042_RS20950 ENOG4108IQ3 PTS system HV042_RS20955 ENOG4105ETZ PTS System HV042_RS20960 ENOG4105F3R pts system mannose fructose sorbose family iid HV042_RS20970 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HV042_RS20975 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV042_RS20995 ENOG4105CUY Mechanosensitive ion channel HV042_RS21000 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS21005 ENOG4105M6F mutator MutT protein HV042_RS21015 ENOG4108GWT fimbrillin MatB HV042_RS21030 ENOG4106PYX Receptor HV042_RS21045 ENOG4105CBN LysR family transcriptional regulator HV042_RS21050 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HV042_RS21065 ENOG4105F0H myo-inositol catabolism protein HV042_RS21070 ENOG4105EAA nucleoside HV042_RS21075 ENOG4105C85 amino acid HV042_RS21085 ENOG4105CPC Aldo Keto reductase HV042_RS21090 ENOG4105E89 ABC transporter HV042_RS21095 ENOG4105CH2 amidohydrolase HV042_RS21130 ENOG4105WBN Transcriptional regulator (LacI family HV042_RS21135 ENOG4105CAF HipA N-terminal domain protein HV042_RS21145 ENOG4105CID antiterminator HV042_RS21150 ENOG4105CS2 ec 3.2.1.21 HV042_RS21155 ENOG4105C5Y PTS System HV042_RS21160 ENOG4108PZW LysR family Transcriptional regulator HV042_RS21165 ENOG4105C32 Amino acid ABC transporter (Permease) HV042_RS21170 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV042_RS21175 ENOG4105C0Z ABC transporter HV042_RS21180 ENOG4108IV0 ABC, transporter HV042_RS21195 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HV042_RS21200 ENOG4105CNN ABC, transporter HV042_RS21205 ENOG4105C2J ABC transporter HV042_RS21230 ENOG4108J4B Beta-lactamase HV042_RS21240 ENOG4105CRK lysyL-tRNA synthetase HV042_RS21245 ENOG4105DUX Transporter HV042_RS21250 ENOG4105CXN decarboxylase HV042_RS21255 ENOG4105D5Q Arginine ornithine antiporter HV042_RS21260 ENOG4108M3R transcriptional activator CadC HV042_RS21280 ENOG4105CY0 Metallo-Beta-Lactamase HV042_RS21300 ENOG4105KT7 mgtC SapB transporter HV042_RS21305 ENOG4105EAA nucleoside HV042_RS21375 ENOG4108KU3 Integrase HV042_RS21490 ENOG4105DFP Integrase HV042_RS21500 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HV042_RS21505 ENOG4105WQ3 Rna-binding protein HV042_RS21510 ENOG4105C8N cysteinyl-tRNA synthetase HV042_RS21515 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV042_RS21520 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HV042_RS21530 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV042_RS21535 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV042_RS21540 ENOG4105C5B carbamate kinase HV042_RS21545 ENOG4105G5A Protein of unknown function (DUF2877) HV042_RS21550 ENOG4107REC cytoplasmic protein HV042_RS21555 ENOG4107R1Q Membrane protein FdrA HV042_RS21560 ENOG4105DG4 malate L-lactate dehydrogenase HV042_RS21565 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HV042_RS21570 ENOG4105S0E allantoin catabolism protein HV042_RS21575 ENOG4105BZW Glycerate kinase HV042_RS21580 ENOG4105DTE Xanthine uracil vitamin C permease HV042_RS21590 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HV042_RS21600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV042_RS21605 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HV042_RS21610 ENOG41060W2 glyoxylate carboligase HV042_RS21640 ENOG4105N0V mono-oxygenase ydhR HV042_RS21645 ENOG4105CV6 ABC transporter, permease HV042_RS21650 ENOG4108I0Y (ABC) transporter HV042_RS21655 ENOG4108UJV acyl-CoA thioesterase i HV042_RS21660 ENOG4105E1F short-chain dehydrogenase reductase HV042_RS21665 ENOG4107QR8 Thioredoxin HV042_RS21670 ENOG4105C4B ABC transporter, permease HV042_RS21675 ENOG41083J0 (ABC) transporter HV042_RS21680 ENOG4107QX8 SPFH domain, Band 7 family protein HV042_RS21685 ENOG4105G5H Membrane HV042_RS21690 ENOG4108Z6Z Transcriptional regulator HV042_RS21695 ENOG4105C59 p-type ATPase HV042_RS21725 ENOG4105MBR gumn family HV042_RS21730 ENOG4108Z66 YbaK ebsC protein HV042_RS21735 ENOG4105CGH 5'-nucleotidase HV042_RS21740 ENOG4105EU0 Major facilitator Superfamily HV042_RS21745 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV042_RS21750 ENOG4107RE1 Inosine-guanosine kinase HV042_RS21760 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HV042_RS21765 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HV042_RS21780 ENOG4107QMP dna polymerase iii subunits gamma and tau HV042_RS21790 ENOG4105WD1 Membrane HV042_RS21795 ENOG4108URS primosomal replication protein n'' HV042_RS21800 ENOG4106428 Protein of unknown function (DUF2496) HV042_RS21810 ENOG4105EGS Mechanosensitive ion channel HV042_RS21815 ENOG4107XI7 Tetr family transcriptional regulator HV042_RS21820 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV042_RS21825 ENOG4105BZS acriflavin resistance protein HV042_RS21830 ENOG4108UKR Biofilm formation regulator YbaJ HV042_RS21840 ENOG4108UW5 maltose o-acetyltransferase HV042_RS21845 ENOG4105GSJ Inner membrane protein ylaC HV042_RS21860 ENOG4105YK5 50S ribosomal protein L36 HV042_RS21865 ENOG4105NRA 50s ribosomal protein l31 type b HV042_RS21870 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS21875 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HV042_RS21880 ENOG4105CI1 PTS System HV042_RS21885 ENOG4105C4C beta-galactosidase HV042_RS21895 ENOG4105EG2 ABC transporter, permease HV042_RS21905 ENOG4107FKK extracellular solute-binding protein family 1 HV042_RS21915 ENOG41066DG (EAL) domain protein HV042_RS21925 ENOG41061MD high-affinity nickel-transporter HV042_RS21930 ENOG4105KCV RNA signal recognition particle 4.5S RNA HV042_RS21935 ENOG4108VW9 Membrane HV042_RS21965 ENOG41080UX Methyltransferase HV042_RS21970 ENOG4108MNP Glycoprotein polysaccharide metabolism HV042_RS21975 ENOG4105C29 acyl-CoA thioesterase HV042_RS21980 ENOG4106NZI LysR family Transcriptional regulator HV042_RS21985 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV042_RS21990 ENOG4108UQV Membrane HV042_RS21995 ENOG4105BZU Histidine kinase HV042_RS22000 ENOG4108YZA Nitrogen regulatory protein pii HV042_RS22005 ENOG4105BZ1 (ABC) transporter HV042_RS22010 ENOG4105BZ1 (ABC) transporter HV042_RS22015 ENOG4108XM1 transcriptional regulator AsnC family HV042_RS22030 ENOG4108NFA extracellular solute-binding protein HV042_RS22040 ENOG4108TGP Thioesterase superfamily protein HV042_RS22045 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV042_RS22050 ENOG4105EIN peptidylprolyl cis-trans isomerase HV042_RS22055 ENOG4105K70 DNA-binding protein HV042_RS22060 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV042_RS22080 ENOG4105M85 Bola protein HV042_RS22085 ENOG4105IEY (LipO)protein HV042_RS22090 ENOG4105EYM Major Facilitator superfamily HV042_RS22095 ENOG4105E2S oxidase) subunit II HV042_RS22100 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV042_RS22105 ENOG4105CCU oxidase (Subunit III) HV042_RS22110 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV042_RS22115 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HV042_RS22125 ENOG4107HP6 Transcriptional regulator HV042_RS22130 ENOG4105E2X shikimate dehydrogenase HV042_RS22135 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HV042_RS22145 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HV042_RS22155 ENOG4105D2S major facilitator superfamily HV042_RS22160 ENOG4105CT4 transporter HV042_RS22165 ENOG4105CIB oxidoreductase Domain protein HV042_RS22170 ENOG4107RDB Major Facilitator HV042_RS22175 ENOG4108VPT UPF0234 protein HV042_RS22180 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV042_RS22185 ENOG4107S0N DJ-1 family HV042_RS22190 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HV042_RS22195 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV042_RS22200 ENOG4105CTB Polyprenyl synthetase HV042_RS22210 ENOG4105CPC Aldo Keto reductase HV042_RS22215 ENOG4108ZAI phosphatidylglycerophosphatase a HV042_RS22220 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV042_RS22225 ENOG4107YIM Involved in the transcription termination process (By similarity) HV042_RS22230 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV042_RS22235 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV042_RS22240 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HV042_RS22245 ENOG4108KIC (LipO)protein HV042_RS22250 ENOG4105DRB nucleoside-specific channel-forming protein HV042_RS22270 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV042_RS22275 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV042_RS22280 ENOG4105VIE preprotein translocase, subunit YajC HV042_RS22285 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HV042_RS22295 ENOG4108ZYK Acyl carrier protein phosphodiesterase HV042_RS22300 ENOG4105D3R alkyl hydroperoxide reductase HV042_RS22315 ENOG4105EFZ amidohydrolase HV042_RS22325 ENOG4105CHJ isochorismatase hydrolase HV042_RS22330 ENOG4105EQ1 Transcriptional regulator HV042_RS22335 ENOG4107R28 alpha amylase, catalytic region HV042_RS22340 ENOG4105C85 amino acid HV042_RS22345 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV042_RS22350 ENOG4105BZU Histidine kinase HV042_RS22355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV042_RS22360 ENOG4107RH8 nuclease SbcCD subunit D HV042_RS22365 ENOG4105EYH Exonuclease HV042_RS22375 ENOG4105DKQ ROK family HV042_RS22385 ENOG4105NBK UPF0345 protein HV042_RS22390 ENOG4105HBA AroM protein HV042_RS22395 ENOG4105SS3 HV042_RS22400 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV042_RS22405 ENOG4105G4C Periplasmic ligand-binding sensor protein HV042_RS22415 ENOG4105II7 pyrroline-5-carboxylate reductase HV042_RS22420 ENOG4105VIF phosphate starvation-inducible protein HV042_RS22425 ENOG4105G6Z alkaline phosphatase HV042_RS22435 ENOG4105K2J Transcriptional regulator HV042_RS22445 ENOG4105CHR reductase HV042_RS22460 ENOG4105CPF Cell wall formation (By similarity) HV042_RS22465 ENOG4105UNH Membrane HV042_RS22470 ENOG4105FR5 inner membrane protein YaiY HV042_RS22475 ENOG4107QS8 (LipO)protein HV042_RS22480 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV042_RS22490 ENOG4107R6D beta-lactam binding protein AmpH HV042_RS22495 ENOG4105D52 delta-aminolevulinic acid dehydratase HV042_RS22510 ENOG4105E2B Taurine dioxygenase HV042_RS22515 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV042_RS22520 ENOG4108ETV ABC transporter HV042_RS22525 ENOG4106FTQ Taurine ABC transporter, periplasmic HV042_RS22530 ENOG4108KX4 response regulator HV042_RS22535 ENOG4105BZU Histidine kinase HV042_RS22540 ENOG4105CXY transporter HV042_RS22545 ENOG4105C4Y ABC transporter HV042_RS22550 ENOG4107RCV ABC transporter, permease HV042_RS22555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV042_RS22560 ENOG4107QK5 Homocysteine s-methyltransferase HV042_RS22565 ENOG4108IQI permease HV042_RS22575 ENOG4105CUB amino acid HV042_RS22580 ENOG4105CPD ethanolamine ammonia-lyase HV042_RS22585 ENOG4107FQ9 ethanolamine ammonia-lyase HV042_RS22600 ENOG4105C32 Amino acid ABC transporter (Permease) HV042_RS22605 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV042_RS22610 ENOG4105C0Z ABC transporter HV042_RS22615 ENOG4108IV0 ABC, transporter HV042_RS22625 ENOG4105CT1 (ABC) transporter HV042_RS22630 ENOG4105CDA abc transporter atp-binding protein HV042_RS22635 ENOG4105E5Q amino acid AbC transporter HV042_RS22640 ENOG4105DRP amino acid AbC transporter HV042_RS22650 ENOG4106PYX Receptor HV042_RS22655 ENOG4108N3D putative enzyme HV042_RS22660 ENOG4108NN8 Fimbrial protein HV042_RS22680 ENOG4105EHI Phosphonate ABC transporter, periplasmic HV042_RS22690 ENOG4105S7S phosphonate abc transporter HV042_RS22720 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV042_RS22730 ENOG41090KR LysR family transcriptional Regulator HV042_RS22735 ENOG4108QBX (LipO)protein HV042_RS22740 ENOG4105FCK Membrane HV042_RS22745 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HV042_RS22750 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HV042_RS22770 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV042_RS22780 ENOG4105KVH Transcriptional regulator HV042_RS22795 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV042_RS22815 ENOG41082JN Transcriptional regulator HV042_RS22830 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV042_RS22840 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS22850 ENOG41079KZ Major Facilitator Superfamily HV042_RS22855 ENOG4105TW1 Carbohydrate-selective porin OprB HV042_RS22860 ENOG4105DTA methyltransferase HV042_RS22865 ENOG41080VW acetyltransferase HV042_RS22880 ENOG4105DEI Mannitol dehydrogenase HV042_RS22885 ENOG4105C6F GntR Family Transcriptional Regulator HV042_RS22905 ENOG4105C26 Dehydrogenase HV042_RS22910 ENOG4105D3Q Sugar transferase HV042_RS22940 ENOG4106WTF Glycosyl transferase, family 2 HV042_RS22945 ENOG4105CG5 Glycosyl transferase (Group 1 HV042_RS22950 ENOG4107RA4 Glycosyl transferase (Group 1 HV042_RS22965 ENOG4105D7W serine acetyltransferase HV042_RS22970 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HV042_RS22980 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HV042_RS22985 ENOG4105CIN aminoacyl-histidine dipeptidase HV042_RS22990 ENOG4108HYG acetyltransferase HV042_RS22995 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV042_RS23010 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HV042_RS23015 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV042_RS23020 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV042_RS23025 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV042_RS23040 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV042_RS23045 ENOG4105E7A Glutamine amidotransferase HV042_RS23055 ENOG4107QPN acyl-Coa dehydrogenase HV042_RS23060 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV042_RS23070 ENOG4107RZZ dna polymerase iii epsilon subunit HV042_RS23075 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV042_RS23080 ENOG4105D1A Methyltransferase HV042_RS23085 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HV042_RS23090 ENOG4105E9H Lytic Murein transglycosylase HV042_RS23095 ENOG4105F2W methyltransferase HV042_RS23105 ENOG4105F27 Major Facilitator HV042_RS23110 ENOG4105HEI LysR family (Transcriptional regulator HV042_RS23115 ENOG4105CV8 reductase HV042_RS23150 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV042_RS23155 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV042_RS23160 ENOG4108UMI ABC transporter, permease HV042_RS23165 ENOG4105D01 (LipO)protein HV042_RS23170 ENOG4108R8X outer membrane lipoprotein HV042_RS23175 ENOG4108R96 Methyltransferase, YaeB family HV042_RS23180 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HV042_RS23185 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV042_RS23190 ENOG4108YZN class I peptide chain release factor HV042_RS23195 ENOG4108VWS Yaeq family HV042_RS23200 ENOG4105W1I UPF0253 protein HV042_RS23205 ENOG4105M1T rho-binding antiterminator HV042_RS23210 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV042_RS23215 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV042_RS23220 ENOG4105CXN decarboxylase HV042_RS23225 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HV042_RS23230 ENOG4105C0B DNA polymerase III (alpha subunit) HV042_RS23235 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV042_RS23250 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HV042_RS23255 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV042_RS23260 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV042_RS23265 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV042_RS23270 ENOG4105DZP Membrane-associated zinc metalloprotease HV042_RS23275 ENOG4105KNE Phosphatidate cytidylyltransferase HV042_RS23285 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV042_RS23290 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HV042_RS23295 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HV042_RS23300 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HV042_RS23310 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV042_RS23315 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HV042_RS23320 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HV042_RS23325 ENOG4108T8E UPF0325 protein HV042_RS23330 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV042_RS23335 ENOG4105C0H protease HV042_RS23340 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HV042_RS23345 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HV042_RS23350 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV042_RS23355 ENOG4105EN6 Membrane HV042_RS23365 ENOG4105CMQ Chloride channel HV042_RS23370 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HV042_RS23375 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV042_RS23380 ENOG4105J76 Periplasmic binding protein HV042_RS23385 ENOG4105E0A ABC, transporter HV042_RS23390 ENOG4105E0K tonB-dependent siderophore receptor HV042_RS23395 ENOG4105BZ4 penicillin-binding protein HV042_RS23480 ENOG4105CQ7 ATP-dependent helicase HV042_RS23485 ENOG4107XID 2'-5' rna ligase HV042_RS23490 ENOG4105PW4 Sugar fermentation stimulation protein homolog HV042_RS23495 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HV042_RS23505 ENOG4105DJ0 Poly(A) Polymerase HV042_RS23510 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV042_RS23515 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HV042_RS23525 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HV042_RS23530 ENOG4107BJW polysaccharide deacetylase HV042_RS23535 ENOG4108YTN IIa component HV042_RS23540 ENOG4105E3A (ABC) transporter HV042_RS23545 ENOG4105DA5 (ABC) transporter HV042_RS23550 ENOG41077A9 carbonic anhydrase HV042_RS23555 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV042_RS23560 ENOG4105DZG Dehydrogenase HV042_RS23565 ENOG4105E3B Multicopper oxidase HV042_RS23570 ENOG4108ZRK uncharacterized protein yacC HV042_RS23580 ENOG4108V1T peptidylprolyl cis-trans isomerase HV042_RS23585 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HV042_RS23590 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HV042_RS23600 ENOG4107QIJ Aconitate hydratase 2 HV042_RS23605 ENOG4108NST exported protein HV042_RS23620 ENOG4107QN2 dihydrolipoyl dehydrogenase HV042_RS23625 ENOG4107QSN dihydrolipoamide acetyltransferase HV042_RS23630 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV042_RS23635 ENOG41073TP transcriptional regulator HV042_RS23640 ENOG4105C85 amino acid HV042_RS23645 ENOG4105CT4 transporter HV042_RS23650 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HV042_RS23655 ENOG4106A72 regulatory protein AmpE HV042_RS23665 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV042_RS23670 ENOG4108ZUW Major pilin subunit HV042_RS23675 ENOG4107QHF type ii secretion system protein e HV042_RS23680 ENOG4105D7Q type ii secretion system HV042_RS23690 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV042_RS23700 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HV042_RS23705 ENOG4105M6F mutator MutT protein HV042_RS23710 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HV042_RS23715 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HV042_RS23720 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV042_RS23725 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV042_RS23730 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV042_RS23735 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV042_RS23750 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HV042_RS23755 ENOG4105CNI cell division protein FtsW HV042_RS23760 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HV042_RS23765 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HV042_RS23770 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV042_RS23775 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV042_RS23780 ENOG4105CJN penicillin-binding protein HV042_RS23785 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV042_RS23800 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV042_RS23805 ENOG4108ZP8 Acetolactate synthase small subunit HV042_RS23810 ENOG4105C7K acetolactate synthase HV042_RS23815 ENOG41064T2 transcriptional regulator, lysR family HV042_RS23825 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HV042_RS23835 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV042_RS23840 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV042_RS23850 ENOG4105E2X shikimate dehydrogenase HV042_RS23855 ENOG4105EMV Major Facilitator HV042_RS23860 ENOG4105FF2 Type I DHQase HV042_RS23865 ENOG4108W5M transcriptional regulator HV042_RS23870 ENOG4105DJB Major Facilitator Superfamily HV042_RS23875 ENOG4105S8Q sugar efflux transporter HV042_RS23895 ENOG4106SMU thiamine transporter membrane protein HV042_RS23905 ENOG4108KF1 Membrane HV042_RS23910 ENOG41063TF transcriptional regulator (AraC HV042_RS23920 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HV042_RS23925 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV042_RS23930 ENOG4105CQ2 DNA polymerase HV042_RS23940 ENOG4105D3G Pseudouridine synthase HV042_RS23950 ENOG4105D2K citrate carrier protein HV042_RS23955 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV042_RS23960 ENOG4106YYS transcriptional regulatory protein HV042_RS23965 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HV042_RS23980 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HV042_RS23985 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HV042_RS24000 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HV042_RS24020 ENOG4105M5B (LipO)protein HV042_RS24025 ENOG41066F8 ROK family HV042_RS24030 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV042_RS24035 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV042_RS24040 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HV042_RS24045 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HV042_RS24050 ENOG4105CHY citrate lyase, alpha HV042_RS24055 ENOG4105CI0 Citrate lyase HV042_RS24065 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV042_RS24070 ENOG4105D2K citrate carrier protein HV042_RS24075 ENOG4106AFN Lyase and sodium transporter (By similarity) HV042_RS24080 ENOG4107QSA Oxaloacetate decarboxylase HV042_RS24085 ENOG4105D9Q decarboxylase (Beta subunit) HV042_RS24090 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV042_RS24095 ENOG4106YYS transcriptional regulatory protein HV042_RS24100 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HV042_RS24105 ENOG4105EXG Transcriptional regulator HV042_RS24115 ENOG4107QM5 aconitate hydratase HV042_RS24120 ENOG4105C8P )-transporter HV042_RS24125 ENOG4107QPK )-transporter HV042_RS24130 ENOG4105C7F AcnD-accessory protein PrpF HV042_RS24135 ENOG4105F04 LysR family Transcriptional regulator HV042_RS24145 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HV042_RS24150 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV042_RS24165 ENOG4105DTN riboflavin biosynthesis protein ribF HV042_RS24175 ENOG41063Z6 transcriptional regulator, lysR family HV042_RS24180 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV042_RS24195 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HV042_RS24200 ENOG4105CFG Acts as a chaperone (By similarity) HV042_RS24210 ENOG4108QUJ UPF0174 protein YaaW HV042_RS24215 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV042_RS24220 ENOG4105CSH Transporter HV042_RS24225 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV042_RS24230 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV042_RS24235 ENOG4105BZG amino acid carrier protein HV042_RS24240 ENOG4105D1Q UPF0246 protein HV042_RS24245 ENOG4105D98 threonine synthase HV042_RS24250 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HV042_RS24255 ENOG4105CFH Aspartokinase HV042_RS24265 ENOG4106FVC RNA methyltransferase HV042_RS24270 ENOG410759A HV042_RS24275 ENOG41065U4 response regulator HV042_RS24280 ENOG4105CT7 inner membrane cred family protein HV042_RS24285 ENOG4105EB3 Histidine kinase HV042_RS24290 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV042_RS24295 ENOG4108RH0 Crea protein HV042_RS24300 ENOG4105UEI Transcriptional Regulator AraC Family HV042_RS24305 ENOG4105CVJ phosphoglycerate mutase HV042_RS24320 ENOG4107SC1 transglycosylase HV042_RS24325 ENOG4105C5H ABC transporter HV042_RS24330 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV042_RS24335 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV042_RS24340 ENOG4105EAC phosphoserine phosphatase HV042_RS24345 ENOG41062Z9 Membrane HV042_RS24350 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HV042_RS24355 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HV042_RS24375 ENOG4105D9N nucleoside HV042_RS24380 ENOG4105EYA deoxyribonuclease HV042_RS24385 ENOG4108NRW Phospholipase, patatin family HV042_RS24395 ENOG4105K3G Periplasmic Protein HV042_RS24400 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HV042_RS24405 ENOG4105PAD Hydrolase HV042_RS24410 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV042_RS24415 ENOG4108WPU DNA polymerase III subunit psi HV042_RS24440 ENOG4105YBH Protein of unknown function (DUF1435) HV042_RS24445 ENOG4106TD9 Diguanylate cyclase HV042_RS24450 ENOG4108819 ferric iron reductase HV042_RS24455 ENOG4105CK1 PTS System HV042_RS24460 ENOG4108UIN ybak prolyl-trna synthetase associated region HV042_RS24465 ENOG4108T94 DNA-binding transcriptional activator BglJ HV042_RS24470 ENOG4108N8T regulatoR HV042_RS24475 ENOG4108R6W Transcriptional regulator, ARAC family HV042_RS24480 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HV042_RS24485 ENOG4105DWK Membrane HV042_RS24495 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HV042_RS24500 ENOG4106CVF DNA replication protein HV042_RS24505 ENOG4105RI1 glycoprotein receptor HV042_RS24510 ENOG4107RES phosphoglycerol transferase I HV042_RS24515 ENOG4105DNE Transposase HV042_RS24520 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV042_RS24530 ENOG4105F3R pts system mannose fructose sorbose family iid HV042_RS24535 ENOG4105ETZ PTS System HV042_RS24540 ENOG4105KPI PTS system sorbose subfamily IIB component HV042_RS24550 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV042_RS24560 ENOG4105CPQ Dehydrogenase HV042_RS24565 ENOG410617M Transcriptional regulator HV042_RS24570 ENOG4108I5G Major Facilitator superfamily HV042_RS24575 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV042_RS24580 ENOG4105XYF acetyltransferase HV042_RS24585 ENOG4106KNT transcriptional regulator HV042_RS24590 ENOG4108RTU Aldolase HV042_RS24595 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HV042_RS24600 ENOG4108IA2 Sodium pantothenate symporter HV042_RS24620 ENOG4108V8F Transcriptional regulator, MarR family HV042_RS24625 ENOG4105ERH Fumarylacetoacetate hydrolase HV042_RS24635 ENOG4105C26 Dehydrogenase HV042_RS24640 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HV042_RS24670 ENOG4105EFA 4-hydroxyphenylacetate HV042_RS24680 ENOG4105D22 carbon starvation protein HV042_RS24685 ENOG4105VCD cytoplasmic protein HV042_RS24690 ENOG4105CKI cobalamin synthesis protein HV042_RS24705 ENOG4105C26 Dehydrogenase HV042_RS24715 ENOG41063TF transcriptional regulator (AraC HV042_RS24730 ENOG4106BRA Membrane HV042_RS24735 ENOG41083G8 Multidrug resistance protein MdtM HV042_RS24740 ENOG4105GTN ParB Domain Protein Nuclease HV042_RS24745 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV042_RS24755 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HV042_RS24760 ENOG4105CIZ coA-substrate-specific enzyme activase HV042_RS24775 ENOG4108P2H Inner membrane protein YjiG HV042_RS24780 ENOG41074DU domain protein HV042_RS24785 ENOG4105DND Transcriptional regulator HV042_RS24795 ENOG4105EFX secretion protein, HlyD family HV042_RS24805 ENOG4106DIZ Domain of unknown function (DUF1127) HV042_RS24815 ENOG4106H3A restriction HV042_RS24820 ENOG4105CVR type I restriction-modification system HV042_RS24825 ENOG4105EKX Restriction modification system DNA (Specificity HV042_RS24830 ENOG4105DZR Type I site-specific deoxyribonuclease HV042_RS24835 ENOG4105E0A ABC, transporter HV042_RS24855 ENOG4105CUB amino acid HV042_RS24870 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HV042_RS24890 ENOG4105KNY Microcompartments protein HV042_RS24895 ENOG4105KNY Microcompartments protein HV042_RS24900 ENOG4105KNY Microcompartments protein HV042_RS24905 ENOG4105C0A alcohol dehydrogenase HV042_RS24920 ENOG4105C6N Formate acetyltransferase HV042_RS24925 ENOG4105F1A Pyruvate formate-lyase HV042_RS24930 ENOG4105KNY Microcompartments protein HV042_RS24935 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HV042_RS24965 ENOG4105CIC tryptophan-specific transport protein HV042_RS24975 ENOG4105BZU Histidine kinase HV042_RS24980 ENOG4105D0S secretion protein (HlyD HV042_RS24985 ENOG4105CJ1 ABC, transporter HV042_RS24990 ENOG4105CMI transporter HV042_RS25020 ENOG4105EZE Cupin 4 family protein HV042_RS25025 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HV042_RS25030 ENOG4107XMU Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV042_RS25040 ENOG4105CSH Transporter HV042_RS25050 ENOG4105C54 Major Facilitator superfamily HV042_RS25055 ENOG4105CXK mandelate racemase muconate lactonizing HV042_RS25060 ENOG4108R85 Short chain dehydrogenase HV042_RS25075 ENOG4105WBN Transcriptional regulator (LacI family HV042_RS25135 ENOG4105ZTC transcriptional activator, Ogr delta HV042_RS25160 ENOG4105DQ4 alcohol dehydrogenase HV042_RS25170 ENOG4105DRS transport system, permease HV042_RS25175 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV042_RS25180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV042_RS25190 ENOG4107QNK )-transporter HV042_RS25195 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HV042_RS25200 ENOG4105F0H myo-inositol catabolism protein HV042_RS25210 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HV042_RS25215 ENOG4105D7K pfkb domain protein HV042_RS25220 ENOG4105CHC glucokinase (EC 2.7.1.2) HV042_RS25225 ENOG4105DH8 myo-inositol catabolism HV042_RS25230 ENOG4105C26 Dehydrogenase HV042_RS25240 ENOG4105D7A ATP-binding protein HV042_RS25245 ENOG4108K5H permease YjgP YjgQ family protein HV042_RS25250 ENOG4108M8S permease YjgP YjgQ family protein HV042_RS25255 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV042_RS25260 ENOG4105MYG DNA polymerase iii, chi subunit HV042_RS25265 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV042_RS25270 ENOG4108MJ3 acetyltransferase HV042_RS25275 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HV042_RS25280 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV042_RS25290 ENOG4105XEP YhcH YjgK YiaL family protein HV042_RS25305 ENOG4105CXT aspartate transcarbamylase HV042_RS25310 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HV042_RS25315 ENOG4105KME endoribonuclease L-psp HV042_RS25325 ENOG4105D4X repressor HV042_RS25330 ENOG4105C5Y PTS System HV042_RS25335 ENOG4105CG3 alpha amylase, catalytic region HV042_RS25340 ENOG4105CK1 PTS System HV042_RS25345 ENOG4105F8D glycoside hydrolase family 4 HV042_RS25360 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV042_RS25365 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV042_RS25370 ENOG4105CS6 Rhs element vgr protein HV042_RS25390 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HV042_RS25405 ENOG41069H0 dihydroorotase EC 3.5.2.3 HV042_RS25435 ENOG4108XVM Cytochrome b(562) HV042_RS25440 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV042_RS25445 ENOG4105N42 UPF0307 protein HV042_RS25450 ENOG4105C26 Dehydrogenase HV042_RS25470 ENOG4105DFU Cell wall formation (By similarity) HV042_RS25480 ENOG41062B0 ABC transporter, permease HV042_RS25485 ENOG4107R9N ABC transporter HV042_RS25490 ENOG4105C2J ABC transporter HV042_RS25495 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV042_RS25500 ENOG4105F0N pyrophosphate phospho-hydrolase HV042_RS25505 ENOG4108ZHD aig2 family HV042_RS25510 ENOG4105MA0 exported protein HV042_RS25515 ENOG4105CFU surface antigen HV042_RS25525 ENOG4105C37 (CBS) domain HV042_RS25535 ENOG4105C4C beta-galactosidase HV042_RS25545 ENOG41061GZ Protein of unknown function (DUF1107) HV042_RS25550 ENOG4108UUE Transcriptional regulator HV042_RS25555 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV042_RS25560 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HV042_RS25565 ENOG4105KVH Transcriptional regulator HV042_RS25570 ENOG4105ECR NmrA family HV042_RS25580 ENOG4105DXC membrane HV042_RS25585 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HV042_RS25595 ENOG4108V1T peptidylprolyl cis-trans isomerase HV042_RS25600 ENOG4105FHY Opacity-associated protein A HV042_RS25610 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HV042_RS25615 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV042_RS25620 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HV042_RS25630 ENOG4105KIT UPF0379 protein yjfY HV042_RS25680 ENOG4108MXZ Esterase HV042_RS25685 ENOG4105WSB biofilm stress and motility protein A HV042_RS25690 ENOG4105S17 UPF0379 protein yjfN HV042_RS25695 ENOG4105CSU acyl-Coa dehydrogenase HV042_RS25705 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV042_RS25710 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV042_RS25715 ENOG4105KPV Transcriptional regulator HV042_RS25735 ENOG4105EPW hflc protein HV042_RS25740 ENOG4107QJR hflk protein HV042_RS25745 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV042_RS25755 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HV042_RS25765 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV042_RS25770 ENOG4105K8N protein family UPF0079, ATPase HV042_RS25775 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV042_RS25780 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV042_RS25800 ENOG4106TNF Periplasmic binding protein HV042_RS25805 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HV042_RS25815 ENOG4105DJ4 phosphatidylserine decarboxylase HV042_RS25820 ENOG4105EGS Mechanosensitive ion channel HV042_RS25830 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV042_RS25835 ENOG4105E33 succinate dehydrogenase HV042_RS25845 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HV042_RS25850 ENOG4105QNF Outer membrane lipoprotein HV042_RS25855 ENOG4105KPY Small multidrug resistance protein HV042_RS25875 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV042_RS25890 ENOG4105F2I Transposase HV042_RS25905 ENOG4105CW0 outer membrane usher protein HV042_RS25935 ENOG4108JJA ABC, transporter HV042_RS25940 ENOG4105MTB Uncharacterized protein YjeJ HV042_RS25945 ENOG4108ZVF (LipO)protein HV042_RS25950 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HV042_RS25960 ENOG4105DVH amino acid HV042_RS25975 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV042_RS25980 ENOG4108IJ0 Aspartate ammonia-lyase HV042_RS25985 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV042_RS25995 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV042_RS26000 ENOG4108SIC Transcriptional regulator HV042_RS26015 ENOG4106IKR HV042_RS26020 ENOG4105UZW Tail fiber assembly protein HV042_RS26025 ENOG4108X9F tail fiber protein HV042_RS26035 ENOG4108T86 baseplate J family protein HV042_RS26065 ENOG41062PQ Mu-like prophage FluMu protein gp41 HV042_RS26075 ENOG4105TKZ Tail Sheath HV042_RS26105 ENOG4105EFV Major head subunit HV042_RS26130 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HV042_RS26135 ENOG4108Z6H mu-like prophage Flumu protein gp27 HV042_RS26215 ENOG4108WTW DNA transposition protein HV042_RS26225 ENOG4105R8V Transcriptional regulator HV042_RS26245 ENOG4105K64 Glycosyl transferase, family 2 HV042_RS26260 ENOG4105DYS nad(p)h dehydrogenase (quinone) HV042_RS26275 ENOG4108ZCF integral membrane protein HV042_RS26290 ENOG4105CSH Transporter HV042_RS26295 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV042_RS26300 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV042_RS26305 ENOG4107RJJ Transcriptional regulator HV042_RS26310 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HV042_RS26315 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HV042_RS26320 ENOG4105EKV Phosphonate metabolism protein HV042_RS26325 ENOG4105FT8 Phosphonate metabolism HV042_RS26330 ENOG4105ENV phosphonate C-P lyase system protein PhnK HV042_RS26335 ENOG4105HRV phosphonate c-p lyase system protein phnl HV042_RS26340 ENOG4105FD8 phosphonate metabolism protein PhnM HV042_RS26345 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HV042_RS26350 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HV042_RS26360 ENOG4108YZG isomerase HV042_RS26365 ENOG4105NYY transcriptional regulator, RpiR HV042_RS26370 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV042_RS26375 ENOG4105C2J ABC transporter HV042_RS26380 ENOG4105CNN ABC, transporter HV042_RS26385 ENOG4105UP7 3-epimerase HV042_RS26390 ENOG4107TFG D-allose kinase HV042_RS26395 ENOG4105EUZ Beta-lactamase domain protein HV042_RS26405 ENOG4105J12 Multidrug resistance protein mdtN HV042_RS26410 ENOG4108MI0 Resistance protein HV042_RS26415 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV042_RS26425 ENOG41082ND Uncharacterized protein yjcO HV042_RS26430 ENOG4105CK2 sodium dicarboxylate symporter HV042_RS26435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV042_RS26440 ENOG41062QD Membrane HV042_RS26445 ENOG4107QN1 sodium solute HV042_RS26460 ENOG4105CW0 outer membrane usher protein HV042_RS26465 ENOG4108VCD Chaperone HV042_RS26485 ENOG4105CMU LysR family (Transcriptional regulator HV042_RS26505 ENOG4105F2I Transposase HV042_RS26520 ENOG4105EEQ Na H antiporter HV042_RS26525 ENOG4105C7N Xanthine uracil vitamin C permease HV042_RS26530 ENOG4108K3A Glutathione S-transferase HV042_RS26535 ENOG4108Z4X TRANSCRIPTIONal HV042_RS26540 ENOG4108W3Q Transcriptional regulator HV042_RS26545 ENOG4108M8H domain protein HV042_RS26550 ENOG4105PMV Membrane HV042_RS26560 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV042_RS26565 ENOG4108DMH HTH_ARAC HV042_RS26570 ENOG4107RNH Outer membrane receptor FepA HV042_RS26580 ENOG4108UUM single-stranded DNA-binding protein HV042_RS26585 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV042_RS26600 ENOG4105MSB protein, conserved in bacteria HV042_RS26605 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HV042_RS26615 ENOG4105CGF Aromatic amino acid aminotransferase HV042_RS26620 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV042_RS26625 ENOG4105CDU Replicative dna helicase HV042_RS26630 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV042_RS26635 ENOG4105P4Z Phage shock protein G HV042_RS26640 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV042_RS26650 ENOG4105MYN Zinc uptake regulation protein HV042_RS26655 ENOG4105VDW Csbd family HV042_RS26660 ENOG4107R73 Mate efflux family protein HV042_RS26665 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HV042_RS26670 ENOG41080IJ Diacylglycerol kinase HV042_RS26675 ENOG4105E55 glycerol-3-phosphate acyltransferase HV042_RS26685 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HV042_RS26690 ENOG4107W52 maltose operon periplasmic protein HV042_RS26695 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HV042_RS26700 ENOG4108IJ9 (ABC) transporter HV042_RS26705 ENOG4107FKK extracellular solute-binding protein family 1 HV042_RS26710 ENOG4105D56 permease protein HV042_RS26715 ENOG4105EG2 ABC transporter, permease HV042_RS26720 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HV042_RS26730 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV042_RS26740 ENOG4105CFH Aspartokinase HV042_RS26745 ENOG410756H nucleotidyltransferase HV042_RS26760 ENOG4105CYB regulatoR HV042_RS26765 ENOG4105C09 Bile acid HV042_RS26770 ENOG4108ZR5 Conserved Protein HV042_RS26775 ENOG4105FE9 pseudouridine synthase HV042_RS26780 ENOG4105DKT Transcriptional regulator HV042_RS26785 ENOG4105CHR reductase HV042_RS26790 ENOG4108XCU pts system HV042_RS26795 ENOG4105KPI PTS system sorbose subfamily IIB component HV042_RS26800 ENOG4105ETZ PTS System HV042_RS26805 ENOG4105F3R pts system mannose fructose sorbose family iid HV042_RS26810 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV042_RS26815 ENOG4105F9E Shikimate 5-dehydrogenase HV042_RS26840 ENOG4105EAM Na Pi-cotransporter HV042_RS26845 ENOG4105C3R Methionine synthase HV042_RS26850 ENOG41069M3 Transcriptional regulator HV042_RS26860 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HV042_RS26865 ENOG4108I9X Isocitrate lyase HV042_RS26870 ENOG4107QP3 malate synthase g HV042_RS26880 ENOG4105K5X acetyltransferase HV042_RS26905 ENOG4105DC1 bifunctional purine biosynthesis protein purh HV042_RS26910 ENOG4105C12 Phosphoribosylglycinamide synthetase HV042_RS26920 ENOG4105BZU Histidine kinase HV042_RS26930 ENOG4108T8B Protein of unknown function (DUF1481) HV042_RS26935 ENOG4105K70 DNA-binding protein HV042_RS26940 ENOG4105R2J Conserved Protein HV042_RS26955 ENOG4105E09 nadh pyrophosphatase HV042_RS26960 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HV042_RS26965 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HV042_RS26970 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HV042_RS26975 ENOG4105D06 uba thif-type nad fad binding protein HV042_RS26980 ENOG4105WHD thiamine biosynthesis protein ThiS HV042_RS26990 ENOG4105D41 biosynthesis protein thiH HV042_RS26995 ENOG4106TD9 Diguanylate cyclase HV042_RS27005 ENOG4105VCP PTS System HV042_RS27010 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV042_RS27015 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV042_RS27020 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV042_RS27025 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HV042_RS27030 ENOG4108VZM 50s ribosomal protein L10 HV042_RS27045 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV042_RS27050 ENOG4105PM1 preprotein translocase subunit SecE HV042_RS27055 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HV042_RS27085 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV042_RS27090 ENOG4105D4A Cell wall formation (By similarity) HV042_RS27120 ENOG4108RR8 protoporphyrinogen oxidase HV042_RS27125 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV042_RS27130 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV042_RS27135 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HV042_RS27145 ENOG4105CHU acetyl-coa acetyltransferase HV042_RS27155 ENOG4107QK7 reductase HV042_RS27165 ENOG4105MDZ Transcriptional activator rfaH HV042_RS27175 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV042_RS27180 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV042_RS27185 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV042_RS27190 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HV042_RS27195 ENOG4105JC1 sterol-binding domain protein HV042_RS27200 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HV042_RS27205 ENOG4105CGY Dna recombination protein HV042_RS27210 ENOG4107SXA Phosphorylase HV042_RS27215 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV042_RS27230 ENOG4105DZ2 Transcriptional regulator HV042_RS27235 ENOG4105EMK carboxylate amino acid amine transporter HV042_RS27240 ENOG4105DQF Hydrolase HV042_RS27245 ENOG4108EUD Lysophospholipase HV042_RS27250 ENOG410829K Lysine exporter protein (Lyse ygga) HV042_RS27260 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV042_RS27265 ENOG4105C9U ATP-dependent DNA helicase RecQ HV042_RS27270 ENOG4105HDD phospholipase HV042_RS27275 ENOG4108VUY thioesterase Superfamily protein HV042_RS27280 ENOG4105FR1 rard protein HV042_RS27285 ENOG4107QUT magnesium and cobalt transport protein CorA HV042_RS27290 ENOG4105C4R Atp-dependent dna helicase HV042_RS27295 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV042_RS27300 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV042_RS27305 ENOG4105CT0 Protein of unknown function, DUF484 HV042_RS27315 ENOG4105S7Z (LipO)protein HV042_RS27320 ENOG4105XQ6 frataxin-like protein HV042_RS27325 ENOG4107T0K Adenylate cyclase HV042_RS27335 ENOG41076E6 Uroporphyrinogen-III Synthase HV042_RS27340 ENOG4105ECF c-methyltransferase HV042_RS27345 ENOG410601J HemY protein HV042_RS27370 ENOG4105C85 amino acid HV042_RS27380 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HV042_RS27385 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HV042_RS27390 ENOG4105EGZ biosynthesis protein HV042_RS27395 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV042_RS27400 ENOG4108WJ1 acetyltransferase HV042_RS27405 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HV042_RS27410 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV042_RS27415 ENOG4107QQG Dehydrogenase HV042_RS27420 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV042_RS27425 ENOG4105SFE lipopolysaccharide biosynthesis protein HV042_RS27430 ENOG4105ESV Glycosyl transferase, family 4 HV042_RS27435 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV042_RS27445 ENOG4105C1J atp-dependent rna helicase HV042_RS27455 ENOG4105G2Y Transcriptional regulator HV042_RS27465 ENOG4108UQV Membrane HV042_RS27475 ENOG4108KD5 ADP-ribosylation crystallin J1 HV042_RS27485 ENOG4108TFM Kinase, PfkB family HV042_RS27490 ENOG4105C4R Atp-dependent dna helicase HV042_RS27495 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV042_RS27500 ENOG4107SXA Phosphorylase HV042_RS27510 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV042_RS27515 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV042_RS27525 ENOG4105EMY transcriptional regulator HV042_RS27530 ENOG4105C7B Threonine dehydratase HV042_RS27540 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV042_RS27545 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV042_RS27560 ENOG4105C0P Mg chelatase subunit ChlI HV042_RS27565 ENOG4108WFC UPF0438 protein yifE HV042_RS27625 ENOG4108Y73 Membrane HV042_RS27630 ENOG4105EJ2 Transcriptional regulator HV042_RS27635 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HV042_RS27640 ENOG4105C5Q Transcriptional regulator HV042_RS27655 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HV042_RS27670 ENOG4108MEK Metal-binding protein YodA HV042_RS27675 ENOG4106R3P AraC family transcriptional regulator HV042_RS27680 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV042_RS27685 ENOG4105DCT glycerol dehydrogenase HV042_RS27690 ENOG4105E98 transcriptional regulator DeoR family HV042_RS27695 ENOG4105SYT Methylenetetrahydrofolate reductase HV042_RS27700 ENOG4108KB2 LysR family Transcriptional regulator HV042_RS27705 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HV042_RS27710 ENOG4105CFH Aspartokinase HV042_RS27715 ENOG4105C28 cystathionine HV042_RS27730 ENOG4105C25 Primosomal protein n' HV042_RS27735 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS27740 ENOG41063M6 Cell Division Protein HV042_RS27745 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HV042_RS27755 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV042_RS27760 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HV042_RS27765 ENOG4105CTQ phosphohexokinase HV042_RS27770 ENOG41076HS cation diffusion facilitator family transporter HV042_RS27915 ENOG4105ED4 portal protein HV042_RS27950 ENOG4105DFE Dna adenine methylase HV042_RS28000 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV042_RS28005 ENOG4105FMW periplasmic HV042_RS28010 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV042_RS28015 ENOG4105E0F Histidine kinase HV042_RS28020 ENOG4108RPX mosc domain containing protein HV042_RS28025 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV042_RS28035 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV042_RS28040 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV042_RS28045 ENOG4105DET Rhamnulokinase HV042_RS28055 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HV042_RS28060 ENOG4105D4B ABC, transporter HV042_RS28065 ENOG4105C2J ABC transporter HV042_RS28075 ENOG4105F5R ABC transporter HV042_RS28080 ENOG4105C0A alcohol dehydrogenase HV042_RS28085 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HV042_RS28095 ENOG4105CT4 transporter HV042_RS28110 ENOG4108UW5 maltose o-acetyltransferase HV042_RS28115 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV042_RS28135 ENOG4108R66 Conserved Protein HV042_RS28140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS28145 ENOG4108RVA ribokinase HV042_RS28155 ENOG4108UMN azlc family HV042_RS28180 ENOG4105D2N Aldolase HV042_RS28195 ENOG4105CTQ phosphohexokinase HV042_RS28220 ENOG4105ETZ PTS System HV042_RS28225 ENOG4105F3R pts system mannose fructose sorbose family iid HV042_RS28235 ENOG4105E4I Glycoside hydrolase family 28 HV042_RS28255 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV042_RS28260 ENOG4108MG3 formate dehydrogenase HV042_RS28265 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HV042_RS28275 ENOG41068KX affects formate dehydrogenase-N HV042_RS28285 ENOG4105SUU thioesterase domain HV042_RS28290 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HV042_RS28295 ENOG4107S2Z UPF0761 membrane protein HV042_RS28300 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HV042_RS28305 ENOG4105CI3 gtp-binding protein typa HV042_RS28310 ENOG4105C5F glutamine synthetase HV042_RS28315 ENOG4105CUX Signal transduction histidine kinase HV042_RS28320 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV042_RS28325 ENOG4106FIY HV042_RS28330 ENOG4105D4P Coproporphyrinogen iii oxidase HV042_RS28335 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HV042_RS28345 ENOG4105C2M dna polymerase I HV042_RS28350 ENOG4106HNH Acyl-transferase HV042_RS28355 ENOG4108Z33 Thiol disulfide Interchange Protein HV042_RS28360 ENOG4105E27 serine threonine protein kinase HV042_RS28365 ENOG4105PC1 Conserved Protein HV042_RS28370 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV042_RS28375 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV042_RS28395 ENOG4107EJG GntR family transcriptional regulator HV042_RS28400 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV042_RS28405 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS28410 ENOG4108RVA ribokinase HV042_RS28415 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV042_RS28420 ENOG4105CNN ABC, transporter HV042_RS28425 ENOG4105C2J ABC transporter HV042_RS28435 ENOG4105DFH Transport of potassium into the cell (By similarity) HV042_RS28450 ENOG4105CU9 asparagine synthetase A HV042_RS28455 ENOG4108VVK transcriptional Regulator, AsnC HV042_RS28460 ENOG4105QTB Flavodoxin HV042_RS28465 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HV042_RS28475 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV042_RS28500 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HV042_RS28510 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HV042_RS28515 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HV042_RS28525 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV042_RS28530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV042_RS28535 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV042_RS28540 ENOG4105C8U phosphate abc transporter HV042_RS28545 ENOG4105E2Z phosphate ABC transporter (Permease HV042_RS28550 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV042_RS28570 ENOG4105DYC esterase HV042_RS28575 ENOG4107VKM 6-phosphogluconolactonase HV042_RS28580 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV042_RS28585 ENOG4105C7N Xanthine uracil vitamin C permease HV042_RS28590 ENOG4108YYH Nadph-dependent fmn reductase HV042_RS28595 ENOG4105E8Q phosphopantetheinyl transferase HV042_RS28600 ENOG4105G2Y Transcriptional regulator HV042_RS28610 ENOG4108R66 Conserved Protein HV042_RS28630 ENOG4105QEK Transcriptional regulator HV042_RS28635 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV042_RS28640 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HV042_RS28650 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HV042_RS28655 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HV042_RS28685 ENOG4105DR5 peptidase HV042_RS28695 ENOG4105E3B Multicopper oxidase HV042_RS28700 ENOG4105VR0 copper resistance HV042_RS28705 ENOG4105JDN Copper resistance protein HV042_RS28710 ENOG4108PG2 copper resistance HV042_RS28715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV042_RS28720 ENOG4105GR3 Histidine kinase HV042_RS28730 ENOG4105F2I Transposase HV042_RS28785 ENOG4105KF5 hemolysin expression-modulating protein HV042_RS28855 ENOG4105W1Y Transcriptional regulator HV042_RS28905 ENOG4108T1W Fimbrial subunit type 3 HV042_RS28960 ENOG4105VN1 Heat shock protein HV042_RS28965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV042_RS29040 ENOG4105ETE Transcriptional regulator (LacI family HV042_RS29050 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV042_RS29080 ENOG4106CQM replication HV042_RS29090 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HV042_RS29110 ENOG4107CBI conjugal transfer fertility inhibition protein HV042_RS29140 ENOG4105F2I Transposase HV042_RS29235 ENOG4105MPK DNA polymerase III subunit theta HV042_RS29255 ENOG41073YN Protein of unknown function (DUF1380) HV042_RS29390 ENOG410624V efflux system protein HV042_RS29415 ENOG4105C94 Transporter HV042_RS29425 ENOG4105EQR Transposase IS116 IS110 IS902 HV042_RS29460 ENOG4108BUD transposase HV042_RS29500 ENOG4108BUD transposase HV042_RS29505 ENOG4108UEC Ferritin-like protein HV042_RS29510 ENOG4105F2I Transposase HV042_RS29525 ENOG4108BUD transposase HV042_RS29535 ENOG4105DHJ ABC, transporter HV042_RS29635 ENOG4106JQ7 HV042_RS29655 ENOG4105MPK DNA polymerase III subunit theta HV042_RS29665 ENOG4108UUM single-stranded DNA-binding protein HV042_RS29935 ENOG4107CBI conjugal transfer fertility inhibition protein HV042_RS29970 ENOG4106CQM replication HV042_RS30055 ENOG4108BUD transposase HV042_RS30105 ENOG4105EQR Transposase IS116 IS110 IS902 HV042_RS30115 ENOG4108UEC Ferritin-like protein HV042_RS30120 ENOG4105F2I Transposase HV042_RS30220 ENOG4106JQ7 HV042_RS30240 ENOG4105MPK DNA polymerase III subunit theta HV042_RS30250 ENOG4108UUM single-stranded DNA-binding protein HV042_RS30500 ENOG4107CBI conjugal transfer fertility inhibition protein HV042_RS30525 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HV042_RS30635 ENOG4106JQ7 HV042_RS30655 ENOG4105MPK DNA polymerase III subunit theta HV042_RS30665 ENOG4108UUM single-stranded DNA-binding protein