locus-tag	class	description
IE970_RS00100	COG0582	viral genome integration into host DNA
IE970_RS00110	COG0534	Mate efflux family protein
IE970_RS00120	COG0582	viral genome integration into host DNA
IE970_RS00125	COG1070	Carbohydrate kinase
IE970_RS00130	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS00135	COG1879	ABC-type sugar transport system periplasmic component
IE970_RS00140	COG1129	ABC transporter
IE970_RS00150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IE970_RS00160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE970_RS00165	COG3775	system Galactitol-specific IIC component
IE970_RS00170	COG3414	Phosphotransferase system galactitol-specific IIB component
IE970_RS00190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IE970_RS00195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE970_RS00200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IE970_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS00230	COG1902	pentaerythritol trinitrate reductase activity
IE970_RS00235	COG1881	PFAM PEBP family protein
IE970_RS00240	COG2207	Transcriptional regulator
IE970_RS00250	COG4584	PFAM Integrase catalytic
IE970_RS00255	COG1484	DNA-dependent DNA replication
IE970_RS00260	COG1486	melibiose metabolic process
IE970_RS00265	COG0583	DNA-binding transcription factor activity
IE970_RS00270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS00320	COG2814	Major facilitator Superfamily
IE970_RS00340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IE970_RS00390	COG3504	Conjugal transfer protein
IE970_RS00400	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IE970_RS00450	COG0084	hydrolase, TatD family'
IE970_RS00485	COG2003	Belongs to the UPF0758 family
IE970_RS00550	COG0583	DNA-binding transcription factor activity
IE970_RS00555	COG0667	Aldo Keto reductase
IE970_RS00570	COG1376	ErfK ybiS ycfS ynhG family protein
IE970_RS00610	COG3539	Fimbrial protein
IE970_RS00615	COG3121	Chaperone
IE970_RS00620	COG3188	usher protein
IE970_RS00625	COG3539	Fimbrial protein
IE970_RS00630	COG3539	Fimbrial protein
IE970_RS00635	COG3539	Fimbrial protein
IE970_RS00650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS00650	COG1263	PTS System
IE970_RS00655	COG2188	Transcriptional regulator
IE970_RS00665	COG3615	Tellurite resistance protein tehB
IE970_RS00670	COG5001	Diguanylate cyclase
IE970_RS00670	COG3300	MHYT domain
IE970_RS00680	COG0477	Major facilitator Superfamily
IE970_RS00685	COG0095	Lipoate-protein ligase
IE970_RS00690	COG0583	DNA-binding transcription factor activity
IE970_RS00695	COG1942	4-Oxalocrotonate Tautomerase
IE970_RS00705	COG1082	Xylose isomerase domain protein TIM barrel
IE970_RS00710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS00710	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS00715	COG0673	inositol 2-dehydrogenase activity
IE970_RS00720	COG2814	Major facilitator Superfamily
IE970_RS00730	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IE970_RS00750	COG1289	transmembrane transporter activity
IE970_RS00775	COG2925	Exonuclease
IE970_RS00780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IE970_RS00785	COG0640	Transcriptional regulator
IE970_RS00870	COG2205	protein histidine kinase activity
IE970_RS00875	COG3604	Transcriptional regulator
IE970_RS00890	COG0531	amino acid
IE970_RS00900	COG0583	DNA-binding transcription factor activity
IE970_RS00905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE970_RS00920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IE970_RS00935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IE970_RS00945	COG0107	imidazoleglycerol-phosphate synthase activity
IE970_RS00955	COG1215	transferase activity, transferring glycosyl groups
IE970_RS01030	COG0110	maltose O-acetyltransferase activity
IE970_RS01065	COG1088	dTDP-glucose 4,6-dehydratase activity
IE970_RS01110	COG1253	flavin adenine dinucleotide binding
IE970_RS01115	COG2982	Protein involved in outer membrane biogenesis
IE970_RS01130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IE970_RS01135	COG0443	Heat shock 70 kDa protein
IE970_RS01140	COG0372	Belongs to the citrate synthase family
IE970_RS01145	COG2205	protein histidine kinase activity
IE970_RS01165	COG1301	dicarboxylic acid transport
IE970_RS01175	COG4608	Belongs to the ABC transporter superfamily
IE970_RS01180	COG0444	Belongs to the ABC transporter superfamily
IE970_RS01185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS01190	COG0601	transmembrane transport
IE970_RS01205	COG2267	carboxylic ester hydrolase activity
IE970_RS01215	COG1522	sequence-specific DNA binding
IE970_RS01230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS01260	COG2205	protein histidine kinase activity
IE970_RS01265	COG0745	RESPONSE REGULATOR receiver
IE970_RS01270	COG0826	peptidase U32
IE970_RS01290	COG4608	Belongs to the ABC transporter superfamily
IE970_RS01295	COG0444	Belongs to the ABC transporter superfamily
IE970_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS01305	COG0601	transmembrane transport
IE970_RS01310	COG0747	negative chemotaxis
IE970_RS01315	COG4948	Mandelate Racemase Muconate Lactonizing
IE970_RS01320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE970_RS01330	COG1070	Carbohydrate kinase
IE970_RS01360	COG1830	Aldolase
IE970_RS01365	COG0351	phosphomethylpyrimidine kinase
IE970_RS01375	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IE970_RS01385	COG0583	DNA-binding transcription factor activity
IE970_RS01395	COG2252	PERMEase
IE970_RS01400	COG0583	DNA-binding transcription factor activity
IE970_RS01405	COG5455	response to cobalt ion
IE970_RS01415	COG0489	protein tyrosine kinase activity
IE970_RS01425	COG4808	Protein conserved in bacteria
IE970_RS01430	COG4807	Protein conserved in bacteria
IE970_RS01440	COG3275	phosphorelay sensor kinase activity
IE970_RS01445	COG0789	Transcriptional regulator
IE970_RS01455	COG1174	glycine betaine transport
IE970_RS01460	COG1125	glycine betaine transport
IE970_RS01465	COG1174	glycine betaine transport
IE970_RS01470	COG1732	Glycine betaine
IE970_RS01475	COG1472	Belongs to the glycosyl hydrolase 3 family
IE970_RS01480	COG0277	FAD linked oxidase domain protein
IE970_RS01490	COG1686	Belongs to the peptidase S11 family
IE970_RS01500	COG0586	Pfam SNARE associated Golgi protein
IE970_RS01505	COG1538	Outer membrane efflux protein
IE970_RS01510	COG2226	methyltransferase
IE970_RS01515	COG2723	6-phospho-beta-galactosidase activity
IE970_RS01530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IE970_RS01535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE970_RS01540	COG0625	glutathione transferase activity
IE970_RS01555	COG2271	Major facilitator Superfamily
IE970_RS01560	COG0583	DNA-binding transcription factor activity
IE970_RS01570	COG1346	cytolysis
IE970_RS01580	COG2949	membrane
IE970_RS01590	COG1129	ABC transporter
IE970_RS01605	COG2311	Membrane
IE970_RS01620	COG4771	TonB-dependent receptor
IE970_RS01625	COG0833	amino acid
IE970_RS01630	COG0583	DNA-binding transcription factor activity
IE970_RS01635	COG2855	membrane
IE970_RS01645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS01645	COG1522	sequence-specific DNA binding
IE970_RS01650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IE970_RS01655	COG2313	pseudouridylate synthase activity
IE970_RS01660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS01665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS01665	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IE970_RS01665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS01670	COG1105	Belongs to the carbohydrate kinase PfkB family
IE970_RS01675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS01675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS01680	COG2814	Major facilitator Superfamily
IE970_RS01690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IE970_RS01695	COG0246	Mannitol dehydrogenase
IE970_RS01700	COG0523	cobalamin synthesis protein
IE970_RS01705	COG0671	phosphoesterase, PA-phosphatase related
IE970_RS01710	COG0791	NLP P60 protein
IE970_RS01715	COG2200	EAL domain
IE970_RS01720	COG4166	transmembrane transport
IE970_RS01725	COG4174	ABC transporter (Permease)
IE970_RS01730	COG4239	(ABC) transporter, permease
IE970_RS01735	COG4172	Belongs to the ABC transporter superfamily
IE970_RS01745	COG2814	Major facilitator Superfamily
IE970_RS01750	COG1187	pseudouridine synthase activity
IE970_RS01755	COG1061	Type III restriction enzyme res subunit
IE970_RS01765	COG0494	nUDIX hydrolase
IE970_RS01770	COG1349	DNA-binding transcription factor activity
IE970_RS01845	COG0515	serine threonine protein kinase
IE970_RS01845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IE970_RS01860	COG0515	serine threonine protein kinase
IE970_RS01860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IE970_RS01895	COG2885	chlorophyll binding
IE970_RS01925	COG0628	permease
IE970_RS01940	COG0659	secondary active sulfate transmembrane transporter activity
IE970_RS01945	COG2239	Acts as a magnesium transporter
IE970_RS01950	COG4615	Cyclic peptide transporter
IE970_RS01955	COG3145	DNA-N1-methyladenine dioxygenase activity
IE970_RS01960	COG2169	Transcriptional regulator
IE970_RS01960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE970_RS01975	COG0642	Histidine kinase
IE970_RS01975	COG2198	Histidine kinase
IE970_RS01985	COG0784	Response regulator, receiver
IE970_RS01985	COG2205	protein histidine kinase activity
IE970_RS02010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE970_RS02015	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IE970_RS02020	COG0583	DNA-binding transcription factor activity
IE970_RS02025	COG0584	glycerophosphoryl diester phosphodiesterase
IE970_RS02030	COG2271	Major facilitator Superfamily
IE970_RS02035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IE970_RS02045	COG0247	lactate metabolic process
IE970_RS02055	COG2271	Major facilitator Superfamily
IE970_RS02065	COG1414	Transcriptional regulator
IE970_RS02120	COG3647	Membrane
IE970_RS02150	COG1169	isochorismate synthase
IE970_RS02155	COG2153	protein acetylation
IE970_RS02165	COG0582	viral genome integration into host DNA
IE970_RS02185	COG3121	Chaperone
IE970_RS02195	COG0582	viral genome integration into host DNA
IE970_RS02205	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE970_RS02210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IE970_RS02215	COG0713	ATP synthesis coupled electron transport
IE970_RS02220	COG0839	Belongs to the complex I subunit 6 family
IE970_RS02265	COG0583	DNA-binding transcription factor activity
IE970_RS02270	COG0436	Aminotransferase
IE970_RS02280	COG0471	metal ion transport
IE970_RS02280	COG0490	domain, Protein
IE970_RS02285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE970_RS02310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IE970_RS02315	COG3959	Transketolase, thiamine diphosphate binding domain
IE970_RS02320	COG3037	sugar-specific permease SgaT UlaA
IE970_RS02330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS02335	COG1609	Transcriptional regulator
IE970_RS02345	COG0622	Phosphoesterase
IE970_RS02350	COG0625	glutathione transferase activity
IE970_RS02355	COG0625	glutathione transferase activity
IE970_RS02360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IE970_RS02365	COG1090	epimerase
IE970_RS02385	COG4598	ABC transporter
IE970_RS02390	COG4160	amino acid transport
IE970_RS02410	COG0163	prenyltransferase activity
IE970_RS02415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IE970_RS02420	COG1286	toxin biosynthetic process
IE970_RS02425	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IE970_RS02430	COG0285	dihydrofolate synthase activity
IE970_RS02440	COG0586	Pfam SNARE associated Golgi protein
IE970_RS02450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IE970_RS02470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE970_RS02485	COG3101	peptidyl-lysine hydroxylation
IE970_RS02490	COG0730	response to heat
IE970_RS02515	COG2062	phosphohistidine phosphatase, SixA
IE970_RS02530	COG3691	Protein conserved in bacteria
IE970_RS02545	COG2116	formate transmembrane transporter activity
IE970_RS02570	COG0583	DNA-binding transcription factor activity
IE970_RS02575	COG2807	transmembrane transport
IE970_RS02585	COG0436	Aminotransferase
IE970_RS02590	COG3275	phosphorelay sensor kinase activity
IE970_RS02595	COG3279	Response regulator of the LytR AlgR family
IE970_RS02610	COG3961	Belongs to the TPP enzyme family
IE970_RS02615	COG0667	Aldo Keto reductase
IE970_RS02630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IE970_RS02635	COG2200	EAL domain
IE970_RS02635	COG2199	diguanylate cyclase activity
IE970_RS02650	COG3415	Transposase
IE970_RS02655	COG3415	Transposase
IE970_RS02685	COG0583	DNA-binding transcription factor activity
IE970_RS02690	COG2211	Major facilitator Superfamily
IE970_RS02695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IE970_RS02700	COG0583	DNA-binding transcription factor activity
IE970_RS02705	COG0385	Bile acid
IE970_RS02710	COG3530	Putative quorum-sensing-regulated virulence factor
IE970_RS02730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IE970_RS02770	COG4319	ketosteroid isomerase
IE970_RS02780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IE970_RS02785	COG4208	sulfate ABC transporter
IE970_RS02790	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IE970_RS02795	COG4150	thiosulfate binding
IE970_RS02800	COG2837	iron assimilation
IE970_RS02820	COG0860	N-Acetylmuramoyl-L-alanine amidase
IE970_RS02830	COG2207	Transcriptional regulator
IE970_RS02900	COG4766	ethanolamine catabolic process
IE970_RS02910	COG4810	utilization protein
IE970_RS02920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IE970_RS02925	COG5342	invasion associated locus B
IE970_RS02935	COG0493	'glutamate synthase
IE970_RS02935	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS02940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE970_RS02950	COG1393	Belongs to the ArsC family
IE970_RS02965	COG0400	carboxylic ester hydrolase activity
IE970_RS02975	COG2321	neutral zinc metallopeptidase
IE970_RS02985	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IE970_RS02995	COG2716	regulation of RNA biosynthetic process
IE970_RS03000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IE970_RS03005	COG0628	permease
IE970_RS03010	COG4783	chaperone-mediated protein folding
IE970_RS03015	COG1393	Belongs to the ArsC family
IE970_RS03025	COG2233	PERMEase
IE970_RS03030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IE970_RS03035	COG2723	6-phospho-beta-galactosidase activity
IE970_RS03050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IE970_RS03060	COG2211	Major facilitator Superfamily
IE970_RS03080	COG0248	Ppx GppA phosphatase
IE970_RS03085	COG2200	EAL domain
IE970_RS03095	COG0583	DNA-binding transcription factor activity
IE970_RS03105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IE970_RS03105	COG0519	Catalyzes the synthesis of GMP from XMP
IE970_RS03110	COG0517	IMP dehydrogenase activity
IE970_RS03110	COG0516	GMP reductase activity
IE970_RS03115	COG1570	exodeoxyribonuclease VII activity
IE970_RS03130	COG1645	bacterial-type flagellum-dependent swarming motility
IE970_RS03145	COG0582	viral genome integration into host DNA
IE970_RS03215	COG4695	Portal protein
IE970_RS03270	COG3561	AntA/AntB antirepressor
IE970_RS03305	COG2976	Protein conserved in bacteria
IE970_RS03335	COG4953	penicillin-binding protein 1C
IE970_RS03340	COG2373	Large extracellular alpha-helical protein
IE970_RS03350	COG1473	amidohydrolase
IE970_RS03355	COG2897	thiosulfate sulfurtransferase activity
IE970_RS03370	COG2975	iron-sulfur cluster assembly
IE970_RS03375	COG0633	Ferredoxin
IE970_RS03395	COG0822	iron-sulfur transferase activity
IE970_RS03420	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IE970_RS03425	COG3683	transport system, periplasmic component
IE970_RS03430	COG3711	transcriptional antiterminator
IE970_RS03435	COG2814	Major facilitator Superfamily
IE970_RS03440	COG2017	converts alpha-aldose to the beta-anomer
IE970_RS03445	COG0477	Major facilitator Superfamily
IE970_RS03445	COG2814	Major facilitator Superfamily
IE970_RS03450	COG0457	Tetratricopeptide repeat
IE970_RS03455	COG1940	carbohydrate kinase activity
IE970_RS03460	COG2259	Doxx family
IE970_RS03470	COG1017	nitric oxide dioxygenase activity
IE970_RS03470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE970_RS03475	COG0347	Belongs to the P(II) protein family
IE970_RS03480	COG2204	response regulator
IE970_RS03485	COG3170	Tfp pilus assembly protein FimV
IE970_RS03490	COG2205	protein histidine kinase activity
IE970_RS03495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IE970_RS03495	COG0047	phosphoribosylformylglycinamidine synthase activity
IE970_RS03510	COG0560	Phosphoserine phosphatase
IE970_RS03515	COG1737	Transcriptional regulator
IE970_RS03520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS03530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IE970_RS03550	COG0681	Belongs to the peptidase S26 family
IE970_RS03560	COG3086	response to oxidative stress
IE970_RS03570	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IE970_RS03580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IE970_RS03590	COG0513	Belongs to the DEAD box helicase family
IE970_RS03615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE970_RS03620	COG3118	belongs to the thioredoxin family
IE970_RS03625	COG3148	PFAM DTW domain containing protein
IE970_RS03635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IE970_RS03640	COG5544	Lipoprotein
IE970_RS03645	COG0477	Major facilitator Superfamily
IE970_RS03675	COG0542	response to heat
IE970_RS03690	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE970_RS03695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IE970_RS03705	COG0077	Prephenate dehydratase
IE970_RS03705	COG1605	Chorismate mutase
IE970_RS03715	COG1605	Chorismate mutase
IE970_RS03715	COG0287	Prephenate dehydrogenase
IE970_RS03720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IE970_RS03730	COG2199	diguanylate cyclase activity
IE970_RS03735	COG2885	chlorophyll binding
IE970_RS03790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IE970_RS03820	COG4695	Portal protein
IE970_RS03980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IE970_RS03985	COG4137	Cytochrome C assembly protein
IE970_RS03990	COG4536	flavin adenine dinucleotide binding
IE970_RS04005	COG0497	DNA recombination
IE970_RS04020	COG2867	negative regulation of translational initiation
IE970_RS04035	COG0582	viral genome integration into host DNA
IE970_RS04125	COG3121	Chaperone
IE970_RS04145	COG2197	response regulator
IE970_RS04185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS04190	COG1126	abc transporter atp-binding protein
IE970_RS04195	COG0235	Class ii aldolase
IE970_RS04205	COG4235	cytochrome complex assembly
IE970_RS04205	COG3088	subunit of a heme lyase
IE970_RS04210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IE970_RS04215	COG1138	Cytochrome C-type biogenesis protein
IE970_RS04225	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IE970_RS04230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IE970_RS04245	COG1858	cytochrome C peroxidase
IE970_RS04250	COG2814	Major facilitator Superfamily
IE970_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS04280	COG3188	usher protein
IE970_RS04300	COG3284	Transcriptional regulator
IE970_RS04305	COG0640	Transcriptional regulator
IE970_RS04310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IE970_RS04335	COG4575	ribosome binding
IE970_RS04345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS04350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IE970_RS04360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IE970_RS04365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IE970_RS04375	COG4176	ABC-type proline glycine betaine transport system permease component
IE970_RS04380	COG2113	Glycine betaine
IE970_RS04385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IE970_RS04395	COG1846	Transcriptional regulator
IE970_RS04400	COG1566	PFAM secretion protein HlyD family protein
IE970_RS04405	COG2814	Major facilitator Superfamily
IE970_RS04410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IE970_RS04430	COG1238	metal cluster binding
IE970_RS04435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE970_RS04440	COG2823	Periplasmic or secreted lipoprotein
IE970_RS04470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IE970_RS04490	COG1546	Belongs to the CinA family
IE970_RS04500	COG0803	Belongs to the bacterial solute-binding protein 9 family
IE970_RS04505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE970_RS04515	COG2951	lytic endotransglycosylase activity
IE970_RS04525	COG3730	PTS system glucitol sorbitol-specific
IE970_RS04530	COG3732	PTS system glucitol sorbitol-specific
IE970_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS04545	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS04550	COG1349	DNA-binding transcription factor activity
IE970_RS04575	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IE970_RS04580	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IE970_RS04585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS04590	COG1609	Transcriptional regulator
IE970_RS04595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS04595	COG1263	PTS System
IE970_RS04600	COG2723	6-phospho-beta-galactosidase activity
IE970_RS04605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IE970_RS04615	COG3260	NADH ubiquinone oxidoreductase 20
IE970_RS04620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE970_RS04625	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IE970_RS04625	COG3261	NADH dehydrogenase
IE970_RS04630	COG0650	Formate hydrogenlyase subunit 4
IE970_RS04635	COG0651	ATP synthesis coupled electron transport
IE970_RS04640	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS04655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IE970_RS04660	COG0298	carbon dioxide binding
IE970_RS04665	COG0409	Hydrogenase expression formation protein
IE970_RS04670	COG0309	Hydrogenase expression formation protein (HypE)
IE970_RS04680	COG0657	acetylesterase activity
IE970_RS04680	COG2755	lipolytic protein G-D-S-L family
IE970_RS04685	COG2723	6-phospho-beta-galactosidase activity
IE970_RS04700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS04705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS04710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS04715	COG1447	Phosphotransferase system cellobiose-specific component IIA
IE970_RS04720	COG1940	carbohydrate kinase activity
IE970_RS04725	COG1609	Transcriptional regulator
IE970_RS04735	COG1121	(ABC) transporter
IE970_RS04740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE970_RS04745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE970_RS04765	COG3720	iron ion transport
IE970_RS04770	COG4558	Periplasmic binding protein
IE970_RS04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS04780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IE970_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS04795	COG2271	Major facilitator Superfamily
IE970_RS04800	COG1063	alcohol dehydrogenase
IE970_RS04810	COG1454	alcohol dehydrogenase
IE970_RS04855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE970_RS04860	COG1538	Outer membrane efflux protein
IE970_RS04870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS04875	COG1132	(ABC) transporter
IE970_RS04905	COG3539	Fimbrial protein
IE970_RS04915	COG3121	Chaperone
IE970_RS04920	COG3188	usher protein
IE970_RS04930	COG3539	Fimbrial protein
IE970_RS04965	COG3328	transposase activity
IE970_RS05000	COG0210	DNA helicase
IE970_RS05035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IE970_RS05055	COG0477	Major facilitator Superfamily
IE970_RS05065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IE970_RS05070	COG1388	LysM domain
IE970_RS05070	COG4942	peptidase
IE970_RS05130	COG2234	aminopeptidase activity
IE970_RS05155	COG0720	synthase
IE970_RS05160	COG0602	queuosine metabolic process
IE970_RS05180	COG3956	TIGRFAM MazG family protein
IE970_RS05185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IE970_RS05195	COG4999	Histidine kinase
IE970_RS05195	COG2205	protein histidine kinase activity
IE970_RS05195	COG3850	Histidine kinase
IE970_RS05195	COG3437	response regulator, receiver
IE970_RS05200	COG1929	Belongs to the glycerate kinase type-1 family
IE970_RS05205	COG4948	Mandelate Racemase Muconate Lactonizing
IE970_RS05210	COG4948	Mandelate Racemase Muconate Lactonizing
IE970_RS05215	COG2271	Major facilitator Superfamily
IE970_RS05220	COG0716	FMN binding
IE970_RS05225	COG0564	pseudouridine synthase activity
IE970_RS05230	COG3098	single-species biofilm formation
IE970_RS05245	COG1611	Belongs to the LOG family
IE970_RS05250	COG0814	amino acid
IE970_RS05255	COG1760	l-serine dehydratase
IE970_RS05260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE970_RS05275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS05290	COG0235	Class ii aldolase
IE970_RS05295	COG0738	Major facilitator superfamily
IE970_RS05315	COG1349	DNA-binding transcription factor activity
IE970_RS05325	COG2363	Small membrane protein
IE970_RS05330	COG0583	DNA-binding transcription factor activity
IE970_RS05340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IE970_RS05345	COG2166	iron-sulfur cluster assembly
IE970_RS05350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IE970_RS05355	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IE970_RS05520	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IE970_RS05535	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IE970_RS05550	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS05550	COG1454	alcohol dehydrogenase
IE970_RS05555	COG4656	Part of a membrane complex involved in electron transport
IE970_RS05585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IE970_RS05590	COG0860	N-Acetylmuramoyl-L-alanine amidase
IE970_RS05595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IE970_RS05595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IE970_RS05600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE970_RS05605	COG1074	ATP-dependent DNA helicase activity
IE970_RS05610	COG1025	Belongs to the peptidase M16 family
IE970_RS05615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IE970_RS05620	COG4967	type IV pilus modification protein PilV
IE970_RS05630	COG4795	General secretion pathway protein
IE970_RS05635	COG2165	general secretion pathway protein
IE970_RS05665	COG0861	Integral membrane protein TerC family
IE970_RS05675	COG0667	Aldo Keto reductase
IE970_RS05690	COG1609	Transcriptional regulator
IE970_RS05700	COG2186	Transcriptional regulator
IE970_RS05705	COG2723	6-phospho-beta-galactosidase activity
IE970_RS05710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS05715	COG1609	Transcriptional regulator
IE970_RS05725	COG0583	DNA-binding transcription factor activity
IE970_RS05750	COG1794	racemase activity, acting on amino acids and derivatives
IE970_RS05760	COG1175	transmembrane transport
IE970_RS05765	COG0395	ABC-type sugar transport system, permease component
IE970_RS05770	COG3842	ATPase activity
IE970_RS05780	COG0823	Involved in the tonB-independent uptake of proteins
IE970_RS05805	COG2814	Major facilitator Superfamily
IE970_RS05810	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS05815	COG0823	Involved in the tonB-independent uptake of proteins
IE970_RS05825	COG0183	Belongs to the thiolase family
IE970_RS05840	COG0814	amino acid
IE970_RS05845	COG0667	Aldo Keto reductase
IE970_RS05890	COG0640	Transcriptional regulator
IE970_RS05910	COG0697	spore germination
IE970_RS05915	COG1846	Transcriptional regulator
IE970_RS05920	COG1522	sequence-specific DNA binding
IE970_RS05930	COG2388	GCN5-related N-acetyl-transferase
IE970_RS05935	COG3592	Divergent 4Fe-4S mono-cluster
IE970_RS05950	COG1289	transmembrane transporter activity
IE970_RS05955	COG1538	Outer membrane efflux protein
IE970_RS05960	COG2909	trisaccharide binding
IE970_RS05980	COG1349	DNA-binding transcription factor activity
IE970_RS05995	COG1349	DNA-binding transcription factor activity
IE970_RS06000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE970_RS06005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS06010	COG0738	Major facilitator superfamily
IE970_RS06055	COG1929	Belongs to the glycerate kinase type-1 family
IE970_RS06060	COG3835	regulator
IE970_RS06065	COG2223	nitrite transmembrane transporter activity
IE970_RS06075	COG1393	Belongs to the ArsC family
IE970_RS06080	COG0583	DNA-binding transcription factor activity
IE970_RS06125	COG0667	Aldo Keto reductase
IE970_RS06140	COG2814	Major facilitator Superfamily
IE970_RS06145	COG0778	Nitroreductase
IE970_RS06155	COG0667	Aldo Keto reductase
IE970_RS06165	COG5002	protein histidine kinase activity
IE970_RS06185	COG2223	nitrite transmembrane transporter activity
IE970_RS06200	COG0800	Aldolase
IE970_RS06205	COG3734	2-keto-3-deoxy-galactonokinase
IE970_RS06210	COG2186	Transcriptional regulator
IE970_RS06245	COG0656	L-ascorbic acid biosynthetic process
IE970_RS06250	COG0667	Aldo Keto reductase
IE970_RS06260	COG0702	epimerase
IE970_RS06290	COG4221	oxidoreductase activity
IE970_RS06305	COG1064	alcohol dehydrogenase
IE970_RS06315	COG1309	transcriptional regulator
IE970_RS06335	COG4942	peptidase
IE970_RS06340	COG0583	DNA-binding transcription factor activity
IE970_RS06345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IE970_RS06355	COG1811	Na channel or pump
IE970_RS06375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IE970_RS06390	COG0716	FMN binding
IE970_RS06400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IE970_RS06420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS06420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS06425	COG3715	PTS system
IE970_RS06430	COG3716	PTS system mannose fructose sorbose family IID component
IE970_RS06445	COG1272	protein, Hemolysin III
IE970_RS06455	COG1737	Transcriptional regulator
IE970_RS06460	COG2723	6-phospho-beta-galactosidase activity
IE970_RS06465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IE970_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS06490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE970_RS06495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE970_RS06500	COG0006	proline dipeptidase activity
IE970_RS06520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IE970_RS06525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE970_RS06540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IE970_RS06540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IE970_RS06545	COG1703	isobutyryl-CoA mutase activity
IE970_RS06550	COG1024	Enoyl-CoA hydratase
IE970_RS06555	COG0427	acetyl-CoA hydrolase
IE970_RS06560	COG0583	DNA-binding transcription factor activity
IE970_RS06565	COG2968	Membrane
IE970_RS06575	COG0668	transmembrane transport
IE970_RS06580	COG0191	fructose-bisphosphate aldolase activity
IE970_RS06615	COG1122	ATPase activity
IE970_RS06620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IE970_RS06625	COG0501	Belongs to the peptidase M48B family
IE970_RS06635	COG1166	arginine decarboxylase activity
IE970_RS06660	COG2814	Major facilitator Superfamily
IE970_RS06670	COG2356	endonuclease I
IE970_RS06675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IE970_RS06680	COG0189	ligase activity
IE970_RS06695	COG2197	response regulator
IE970_RS06700	COG2805	Type II/IV secretion system protein
IE970_RS06705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IE970_RS06710	COG0762	integral membrane protein
IE970_RS06725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IE970_RS06730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IE970_RS06735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IE970_RS06750	COG3171	Protein conserved in bacteria
IE970_RS06760	COG1194	a g-specific adenine glycosylase
IE970_RS06775	COG2211	Major facilitator Superfamily
IE970_RS06780	COG1982	Orn Lys Arg decarboxylase major
IE970_RS06785	COG1811	Na channel or pump
IE970_RS06795	COG0582	viral genome integration into host DNA
IE970_RS06840	COG1397	ADP-ribosylglycohydrolase
IE970_RS06860	COG4372	Transposase
IE970_RS06865	COG3436	PFAM IS66 Orf2 family protein
IE970_RS06920	COG2003	Belongs to the UPF0758 family
IE970_RS06930	COG4584	PFAM Integrase catalytic
IE970_RS06945	COG3436	PFAM IS66 Orf2 family protein
IE970_RS06950	COG4372	Transposase
IE970_RS06980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IE970_RS07050	COG3596	GTP binding
IE970_RS07100	COG2003	Belongs to the UPF0758 family
IE970_RS07135	COG3423	Transcriptional regulator
IE970_RS07165	COG0471	metal ion transport
IE970_RS07175	COG0626	cystathionine gamma-synthase activity
IE970_RS07195	COG2365	Tyrosine phosphatase family
IE970_RS07205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE970_RS07210	COG0754	glutathionylspermidine amidase activity
IE970_RS07220	COG0625	glutathione transferase activity
IE970_RS07240	COG0848	biopolymer transport protein
IE970_RS07255	COG0586	Pfam SNARE associated Golgi protein
IE970_RS07260	COG2207	Transcriptional regulator
IE970_RS07265	COG1979	alcohol dehydrogenase
IE970_RS07280	COG1032	radical SAM domain protein
IE970_RS07285	COG2132	Multicopper oxidase
IE970_RS07290	COG0204	Acyl-transferase
IE970_RS07300	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IE970_RS07305	COG3111	PFAM Bacterial OB fold (BOF) protein
IE970_RS07310	COG0745	RESPONSE REGULATOR receiver
IE970_RS07315	COG0642	Histidine kinase
IE970_RS07320	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE970_RS07325	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IE970_RS07335	COG3150	esterase
IE970_RS07340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IE970_RS07345	COG3151	Protein conserved in bacteria
IE970_RS07350	COG0494	nUDIX hydrolase
IE970_RS07365	COG0754	glutathionylspermidine amidase activity
IE970_RS07370	COG3384	dioxygenase
IE970_RS07380	COG3539	Fimbrial protein
IE970_RS07385	COG3188	usher protein
IE970_RS07390	COG3121	Chaperone
IE970_RS07395	COG3539	Fimbrial protein
IE970_RS07405	COG2960	long-chain fatty acid transporting porin activity
IE970_RS07425	COG3025	triphosphatase activity
IE970_RS07430	COG4991	sh3 domain protein
IE970_RS07445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IE970_RS07500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IE970_RS07505	COG0358	DNA primase activity
IE970_RS07600	COG2376	Dihydroxyacetone kinase
IE970_RS07605	COG1461	Dihydroxyacetone kinase
IE970_RS07620	COG2375	cellular response to nickel ion
IE970_RS07625	COG1695	Transcriptional regulator
IE970_RS07635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE970_RS07640	COG1609	Transcriptional regulator
IE970_RS07645	COG3250	beta-galactosidase activity
IE970_RS07650	COG2731	YhcH YjgK YiaL family protein
IE970_RS07655	COG0531	amino acid
IE970_RS07660	COG0531	amino acid
IE970_RS07680	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IE970_RS07680	COG3408	Glycogen debranching enzyme
IE970_RS07725	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE970_RS07725	COG1902	pentaerythritol trinitrate reductase activity
IE970_RS07735	COG2211	Major facilitator Superfamily
IE970_RS07745	COG3507	Belongs to the glycosyl hydrolase 43 family
IE970_RS07750	COG1451	nucleotide metabolic process
IE970_RS07755	COG0673	inositol 2-dehydrogenase activity
IE970_RS07775	COG2721	sulfolactate sulfo-lyase activity
IE970_RS07785	COG2271	Major facilitator Superfamily
IE970_RS07790	COG2186	Transcriptional regulator
IE970_RS07795	COG0586	Pfam SNARE associated Golgi protein
IE970_RS07805	COG1422	Protein of unknown function (DUF1090)
IE970_RS07810	COG4575	ribosome binding
IE970_RS07815	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IE970_RS07825	COG2259	Doxx family
IE970_RS07830	COG0435	Glutathione S-transferase
IE970_RS07835	COG3152	Membrane
IE970_RS07840	COG0583	DNA-binding transcription factor activity
IE970_RS07845	COG1741	Belongs to the pirin family
IE970_RS07865	COG1929	Belongs to the glycerate kinase type-1 family
IE970_RS07870	COG2084	Dehydrogenase
IE970_RS07880	COG2271	Major facilitator Superfamily
IE970_RS07885	COG2721	sulfolactate sulfo-lyase activity
IE970_RS07890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS07895	COG1349	DNA-binding transcription factor activity
IE970_RS07910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS07910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS07910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS07915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS07915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS07920	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
IE970_RS07925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS07930	COG3414	Phosphotransferase system galactitol-specific IIB component
IE970_RS07935	COG3775	system Galactitol-specific IIC component
IE970_RS07940	COG1063	alcohol dehydrogenase
IE970_RS07955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IE970_RS07975	COG2823	Periplasmic or secreted lipoprotein
IE970_RS07980	COG0701	Predicted permease
IE970_RS07985	COG0702	epimerase
IE970_RS07990	COG0693	protein deglycase activity
IE970_RS08000	COG2827	Endonuclease containing a URI domain
IE970_RS08005	COG3153	acetyltransferase
IE970_RS08010	COG3154	lipid carrier protein
IE970_RS08015	COG0826	peptidase U32
IE970_RS08020	COG0826	peptidase U32
IE970_RS08025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS08030	COG0814	amino acid
IE970_RS08035	COG0513	Belongs to the DEAD box helicase family
IE970_RS08070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IE970_RS08075	COG0195	Participates in both transcription termination and antitermination
IE970_RS08100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IE970_RS08110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IE970_RS08115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IE970_RS08125	COG1534	Rna-binding protein
IE970_RS08135	COG2027	D-alanyl-D-alanine carboxypeptidase
IE970_RS08145	COG0697	spore germination
IE970_RS08160	COG0142	geranyltranstransferase activity
IE970_RS08165	COG3423	Transcriptional regulator
IE970_RS08175	COG5007	Belongs to the BolA IbaG family
IE970_RS08180	COG3113	response to antibiotic
IE970_RS08185	COG2854	intermembrane phospholipid transfer
IE970_RS08190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IE970_RS08195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IE970_RS08200	COG1127	ABC transporter
IE970_RS08205	COG0530	calcium, potassium:sodium antiporter activity
IE970_RS08215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IE970_RS08220	COG3117	lipopolysaccharide transmembrane transporter activity
IE970_RS08225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IE970_RS08230	COG1137	ATPase activity
IE970_RS08235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IE970_RS08240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IE970_RS08245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS08250	COG1660	Displays ATPase and GTPase activities
IE970_RS08255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS08260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IE970_RS08265	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IE970_RS08270	COG2198	Histidine kinase
IE970_RS08270	COG5002	protein histidine kinase activity
IE970_RS08270	COG0784	Response regulator, receiver
IE970_RS08275	COG1242	4 iron, 4 sulfur cluster binding
IE970_RS08280	COG0067	glutamate synthase
IE970_RS08280	COG0069	glutamate synthase activity
IE970_RS08280	COG0070	glutamate synthase
IE970_RS08285	COG0493	'glutamate synthase
IE970_RS08290	COG2731	YhcH YjgK YiaL family protein
IE970_RS08320	COG2969	positive regulation of protein catabolic process
IE970_RS08325	COG0625	glutathione transferase activity
IE970_RS08340	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IE970_RS08345	COG3105	Protein conserved in bacteria
IE970_RS08350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE970_RS08355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE970_RS08370	COG5016	pyruvate
IE970_RS08370	COG0511	ligase activity, forming carbon-carbon bonds
IE970_RS08380	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS08385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS08390	COG0471	metal ion transport
IE970_RS08400	COG2188	Transcriptional regulator
IE970_RS08425	COG2732	(Barnase) inhibitor
IE970_RS08430	COG1289	transmembrane transporter activity
IE970_RS08445	COG0583	DNA-binding transcription factor activity
IE970_RS08450	COG1349	DNA-binding transcription factor activity
IE970_RS08455	COG0312	modulator of DNA gyrase
IE970_RS08460	COG3164	Protein of unknown function
IE970_RS08475	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IE970_RS08480	COG1792	Involved in formation and maintenance of cell shape
IE970_RS08485	COG1077	Cell shape determining protein MreB Mrl
IE970_RS08490	COG2199	diguanylate cyclase activity
IE970_RS08490	COG2200	EAL domain
IE970_RS08495	COG0604	alcohol dehydrogenase
IE970_RS08510	COG0511	ligase activity, forming carbon-carbon bonds
IE970_RS08515	COG0439	Biotin carboxylase
IE970_RS08520	COG3924	membrane
IE970_RS08525	COG4145	pantothenate transmembrane transporter activity
IE970_RS08550	COG1309	transcriptional regulator
IE970_RS08555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS08560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE970_RS08600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IE970_RS08620	COG0551	DNA topoisomerase type I activity
IE970_RS08630	COG0758	DNA mediated transformation
IE970_RS08660	COG3036	rescue of stalled ribosome
IE970_RS08665	COG0789	Transcriptional regulator
IE970_RS08675	COG0203	ribosomal protein L17
IE970_RS08680	COG0202	RNA polymerase activity
IE970_RS08690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IE970_RS08705	COG0201	protein transport
IE970_RS08720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IE970_RS08770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IE970_RS08785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IE970_RS08800	COG0088	Forms part of the polypeptide exit tunnel
IE970_RS08810	COG0051	transcription antitermination factor activity, RNA binding
IE970_RS08865	COG2964	Protein conserved in bacteria
IE970_RS08870	COG0545	Peptidyl-prolyl cis-trans isomerase
IE970_RS08880	COG1047	Peptidyl-prolyl cis-trans
IE970_RS08885	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IE970_RS08900	COG0488	(ABC) transporter
IE970_RS08910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IE970_RS08920	COG0429	hydrolase of the alpha beta-hydrolase fold
IE970_RS08930	COG3954	Phosphoribulokinase
IE970_RS08935	COG1765	OsmC-like protein
IE970_RS08945	COG1289	transmembrane transporter activity
IE970_RS08950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IE970_RS08975	COG0738	Major facilitator superfamily
IE970_RS08980	COG0402	S-adenosylhomocysteine deaminase activity
IE970_RS08985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IE970_RS08990	COG2146	nitrite reductase [NAD(P)H] activity
IE970_RS09015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE970_RS09020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IE970_RS09025	COG3266	domain, Protein
IE970_RS09040	COG4796	Type ii and iii secretion system protein
IE970_RS09065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IE970_RS09070	COG0494	nUDIX hydrolase
IE970_RS09080	COG1011	Hydrolase
IE970_RS09085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IE970_RS09100	COG1640	4-alpha-glucanotransferase
IE970_RS09105	COG0058	SHG alpha-glucan phosphorylase activity
IE970_RS09115	COG1349	DNA-binding transcription factor activity
IE970_RS09130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IE970_RS09135	COG0058	SHG alpha-glucan phosphorylase activity
IE970_RS09160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IE970_RS09165	COG2610	gluconate transmembrane transporter activity
IE970_RS09170	COG3265	gluconokinase activity
IE970_RS09175	COG1609	Transcriptional regulator
IE970_RS09180	COG1741	Belongs to the pirin family
IE970_RS09185	COG0673	inositol 2-dehydrogenase activity
IE970_RS09195	COG1247	-acetyltransferase
IE970_RS09200	COG0405	Gamma-glutamyltransferase
IE970_RS09210	COG0584	glycerophosphoryl diester phosphodiesterase
IE970_RS09235	COG1414	Transcriptional regulator
IE970_RS09240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE970_RS09245	COG2271	Major facilitator Superfamily
IE970_RS09250	COG2721	sulfolactate sulfo-lyase activity
IE970_RS09275	COG0683	leucine binding
IE970_RS09285	COG0683	leucine binding
IE970_RS09300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IE970_RS09315	COG2177	Part of the ABC transporter FtsEX involved in
IE970_RS09320	COG2884	Cell division ATP-binding protein ftsE
IE970_RS09325	COG0552	protein localization to endoplasmic reticulum
IE970_RS09330	COG0742	ribosomal rna small subunit methyltransferase
IE970_RS09335	COG3776	membrane
IE970_RS09345	COG3714	YhhN family
IE970_RS09360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IE970_RS09375	COG0628	permease
IE970_RS09405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE970_RS09425	COG1216	Glycosyl transferase, family 2
IE970_RS09450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE970_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS09465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE970_RS09510	COG3479	Phenolic acid decarboxylase
IE970_RS09520	COG0747	negative chemotaxis
IE970_RS09525	COG0601	transmembrane transport
IE970_RS09530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS09535	COG0444	Belongs to the ABC transporter superfamily
IE970_RS09555	COG2239	Acts as a magnesium transporter
IE970_RS09565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE970_RS09570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IE970_RS09575	COG0471	metal ion transport
IE970_RS09580	COG3964	amidohydrolase
IE970_RS09585	COG2204	response regulator
IE970_RS09590	COG2081	HI0933 family
IE970_RS09595	COG0306	phosphate transporter
IE970_RS09605	COG0589	response to stress
IE970_RS09625	COG2610	gluconate transmembrane transporter activity
IE970_RS09660	COG1918	ferrous iron import across plasma membrane
IE970_RS09665	COG2183	response to ionizing radiation
IE970_RS09670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE970_RS09685	COG0671	phosphoesterase, PA-phosphatase related
IE970_RS09690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IE970_RS09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE970_RS09700	COG0625	glutathione transferase activity
IE970_RS09705	COG1454	alcohol dehydrogenase
IE970_RS09725	COG2197	response regulator
IE970_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS09735	COG0583	DNA-binding transcription factor activity
IE970_RS09740	COG1295	ribonuclease BN
IE970_RS09745	COG0477	Major facilitator Superfamily
IE970_RS09750	COG2982	Protein involved in outer membrane biogenesis
IE970_RS09760	COG0612	Peptidase, M16
IE970_RS09770	COG2199	diguanylate cyclase activity
IE970_RS09770	COG2200	EAL domain
IE970_RS09775	COG3118	belongs to the thioredoxin family
IE970_RS09775	COG0457	Tetratricopeptide repeat
IE970_RS09785	COG1215	transferase activity, transferring glycosyl groups
IE970_RS09820	COG2194	sulfuric ester hydrolase activity
IE970_RS09845	COG0457	Tetratricopeptide repeat
IE970_RS09860	COG0489	protein tyrosine kinase activity
IE970_RS09870	COG4608	Belongs to the ABC transporter superfamily
IE970_RS09875	COG0444	Belongs to the ABC transporter superfamily
IE970_RS09880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS09885	COG0601	transmembrane transport
IE970_RS09890	COG0747	negative chemotaxis
IE970_RS09910	COG2223	nitrite transmembrane transporter activity
IE970_RS09915	COG5571	outer membrane autotransporter
IE970_RS09920	COG2818	Glycosylase
IE970_RS09925	COG0456	acetyltransferase
IE970_RS09930	COG0243	molybdopterin cofactor binding
IE970_RS09935	COG2885	chlorophyll binding
IE970_RS09940	COG1609	Transcriptional regulator
IE970_RS09950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS09970	COG2814	Major facilitator Superfamily
IE970_RS09975	COG2944	sequence-specific DNA binding
IE970_RS09980	COG1278	Cold shock
IE970_RS10010	COG3274	enterobacterial common antigen metabolic process
IE970_RS10015	COG4682	membrane
IE970_RS10020	COG1070	Carbohydrate kinase
IE970_RS10025	COG2115	Belongs to the xylose isomerase family
IE970_RS10030	COG4213	ABC transporter substrate-binding protein
IE970_RS10040	COG4214	carbohydrate transport
IE970_RS10045	COG1609	Transcriptional regulator
IE970_RS10045	COG2207	Transcriptional regulator
IE970_RS10050	COG2992	FlgJ-related protein
IE970_RS10055	COG0366	Alpha amylase catalytic
IE970_RS10060	COG3977	Valine--pyruvate aminotransferase
IE970_RS10065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS10070	COG1414	Transcriptional regulator
IE970_RS10080	COG2731	YhcH YjgK YiaL family protein
IE970_RS10095	COG1070	Carbohydrate kinase
IE970_RS10100	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IE970_RS10105	COG3623	hexulose-6-phosphate isomerase
IE970_RS10110	COG0235	Class ii aldolase
IE970_RS10115	COG1917	Cupin 2, conserved barrel domain protein
IE970_RS10115	COG4977	sequence-specific DNA binding
IE970_RS10120	COG2211	Major facilitator Superfamily
IE970_RS10130	COG3276	selenocysteine insertion sequence binding
IE970_RS10140	COG0625	glutathione transferase activity
IE970_RS10145	COG1566	PFAM secretion protein HlyD family protein
IE970_RS10165	COG3722	fumarate hydratase activity
IE970_RS10185	COG2186	Transcriptional regulator
IE970_RS10195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IE970_RS10215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IE970_RS10220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IE970_RS10230	COG4942	peptidase
IE970_RS10235	COG2861	carbohydrate metabolic process
IE970_RS10240	COG0463	Glycosyl transferase, family 2
IE970_RS10250	COG0156	8-amino-7-oxononanoate synthase activity
IE970_RS10260	COG0859	PFAM glycosyl transferase family 9
IE970_RS10265	COG0859	PFAM glycosyl transferase family 9
IE970_RS10290	COG0859	PFAM glycosyl transferase family 9
IE970_RS10300	COG0438	transferase activity, transferring glycosyl groups
IE970_RS10305	COG1216	Glycosyl transferase, family 2
IE970_RS10310	COG1519	Transferase
IE970_RS10330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IE970_RS10335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IE970_RS10345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IE970_RS10360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IE970_RS10370	COG1561	YicC-like family, N-terminal region
IE970_RS10395	COG3561	AntA/AntB antirepressor
IE970_RS10460	COG2860	membrane
IE970_RS10480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IE970_RS10485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE970_RS10490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IE970_RS10495	COG1494	fructose-1,6-bisphosphatase
IE970_RS10505	COG3152	Membrane
IE970_RS10535	COG3074	FtsZ-dependent cytokinesis
IE970_RS10550	COG0786	glutamate:sodium symporter activity
IE970_RS10555	COG2233	PERMEase
IE970_RS10560	COG2982	Protein involved in outer membrane biogenesis
IE970_RS10565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS10565	COG1263	PTS System
IE970_RS10570	COG1486	melibiose metabolic process
IE970_RS10585	COG1940	carbohydrate kinase activity
IE970_RS10590	COG0191	fructose-bisphosphate aldolase activity
IE970_RS10600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS10600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS10605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS10610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS10610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS10610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS10615	COG3711	transcriptional antiterminator
IE970_RS10620	COG1501	Belongs to the glycosyl hydrolase 31 family
IE970_RS10625	COG2211	Major facilitator Superfamily
IE970_RS10635	COG4133	protoheme IX ABC transporter activity
IE970_RS10660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IE970_RS10680	COG1064	alcohol dehydrogenase
IE970_RS10690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IE970_RS10705	COG1464	Belongs to the NlpA lipoprotein family
IE970_RS10720	COG0583	DNA-binding transcription factor activity
IE970_RS10730	COG1309	transcriptional regulator
IE970_RS10740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS10745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE970_RS10755	COG2814	Major facilitator Superfamily
IE970_RS10765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS10765	COG1263	PTS System
IE970_RS10780	COG0697	spore germination
IE970_RS10790	COG5464	transposase or invertase
IE970_RS10800	COG1609	Transcriptional regulator
IE970_RS10810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS10810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS10815	COG1447	Phosphotransferase system cellobiose-specific component IIA
IE970_RS10820	COG4580	involved in the transport of maltose and maltodextrins
IE970_RS10845	COG2188	Transcriptional regulator
IE970_RS10885	COG2271	Major facilitator Superfamily
IE970_RS10895	COG2197	response regulator
IE970_RS10900	COG0440	acetolactate synthase activity
IE970_RS10905	COG0028	Belongs to the TPP enzyme family
IE970_RS10935	COG2814	Major facilitator Superfamily
IE970_RS10940	COG0583	DNA-binding transcription factor activity
IE970_RS10945	COG2610	gluconate transmembrane transporter activity
IE970_RS10955	COG0641	radical SAM
IE970_RS10965	COG2149	membrane
IE970_RS10980	COG2188	Transcriptional regulator
IE970_RS11000	COG5645	(Lipo)protein
IE970_RS11005	COG0823	Involved in the tonB-independent uptake of proteins
IE970_RS11010	COG2271	Major facilitator Superfamily
IE970_RS11020	COG0800	Aldolase
IE970_RS11025	COG3734	2-keto-3-deoxy-galactonokinase
IE970_RS11030	COG2186	Transcriptional regulator
IE970_RS11035	COG0561	phosphatase activity
IE970_RS11045	COG0583	DNA-binding transcription factor activity
IE970_RS11050	COG0187	DNA topoisomerase II activity
IE970_RS11060	COG0592	DNA-directed DNA polymerase activity
IE970_RS11070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IE970_RS11080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IE970_RS11095	COG0456	acetyltransferase
IE970_RS11110	COG2091	lysine biosynthetic process via aminoadipic acid
IE970_RS11115	COG0431	NADPH-dependent FMN reductase
IE970_RS11120	COG2252	PERMEase
IE970_RS11125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE970_RS11130	COG0363	glucosamine-6-phosphate deaminase activity
IE970_RS11135	COG2382	esterase
IE970_RS11145	COG0704	Plays a role in the regulation of phosphate uptake
IE970_RS11150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IE970_RS11155	COG0581	inorganic phosphate transmembrane transporter activity
IE970_RS11160	COG0573	inorganic phosphate transmembrane transporter activity
IE970_RS11165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IE970_RS11170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE970_RS11225	COG3312	ion transport
IE970_RS11240	COG0716	FMN binding
IE970_RS11245	COG1522	sequence-specific DNA binding
IE970_RS11275	COG1129	ABC transporter
IE970_RS11280	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS11290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS11295	COG1609	Transcriptional regulator
IE970_RS11300	COG0477	Major facilitator Superfamily
IE970_RS11305	COG2186	Transcriptional regulator
IE970_RS11325	COG1763	Mo-molybdopterin cofactor biosynthetic process
IE970_RS11335	COG3084	Protein conserved in bacteria
IE970_RS11340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IE970_RS11350	COG0204	Acyl-transferase
IE970_RS11370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IE970_RS11385	COG3852	Histidine kinase
IE970_RS11400	COG1011	Hydrolase
IE970_RS11410	COG1490	D-aminoacyl-tRNA deacylase activity
IE970_RS11415	COG0456	acetyltransferase
IE970_RS11420	COG0657	acetylesterase activity
IE970_RS11430	COG2864	formate dehydrogenase
IE970_RS11435	COG0437	4 iron, 4 sulfur cluster binding
IE970_RS11465	COG3716	PTS system mannose fructose sorbose family IID component
IE970_RS11470	COG3715	PTS system
IE970_RS11480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IE970_RS11495	COG0205	6-phosphofructokinase activity
IE970_RS11535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IE970_RS11580	COG2211	Major facilitator Superfamily
IE970_RS11585	COG0110	maltose O-acetyltransferase activity
IE970_RS11600	COG3539	Fimbrial protein
IE970_RS11610	COG3121	Chaperone
IE970_RS11615	COG3188	usher protein
IE970_RS11620	COG3539	Fimbrial protein
IE970_RS11625	COG3539	Fimbrial protein
IE970_RS11630	COG3539	Fimbrial protein
IE970_RS11635	COG3121	Chaperone
IE970_RS11650	COG0668	transmembrane transport
IE970_RS11665	COG1609	Transcriptional regulator
IE970_RS11670	COG2211	Major facilitator Superfamily
IE970_RS11675	COG1621	beta-fructofuranosidase activity
IE970_RS11695	COG1454	alcohol dehydrogenase
IE970_RS11705	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS11710	COG1129	ABC transporter
IE970_RS11755	COG2258	MOSC domain
IE970_RS11760	COG2205	protein histidine kinase activity
IE970_RS11765	COG0745	RESPONSE REGULATOR receiver
IE970_RS11770	COG3678	ATP-independent chaperone mediated protein folding
IE970_RS11790	COG1575	Belongs to the MenA family. Type 1 subfamily
IE970_RS11805	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IE970_RS11810	COG1609	Transcriptional regulator
IE970_RS11815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IE970_RS11835	COG0626	cystathionine gamma-synthase activity
IE970_RS11840	COG0460	homoserine dehydrogenase
IE970_RS11840	COG0527	aspartate kinase activity
IE970_RS11845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS11850	COG0583	DNA-binding transcription factor activity
IE970_RS11860	COG1349	DNA-binding transcription factor activity
IE970_RS11865	COG0371	Dehydrogenase
IE970_RS11875	COG2207	Transcriptional regulator
IE970_RS11880	COG3443	Belongs to the bacterial solute-binding protein 9 family
IE970_RS11895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IE970_RS11910	COG0583	DNA-binding transcription factor activity
IE970_RS11985	COG3085	chromosome segregation
IE970_RS12005	COG3978	acetolactate synthase activity
IE970_RS12010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IE970_RS12025	COG0583	DNA-binding transcription factor activity
IE970_RS12035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE970_RS12040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE970_RS12075	COG1397	ADP-ribosylglycohydrolase
IE970_RS12095	COG3118	belongs to the thioredoxin family
IE970_RS12100	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IE970_RS12105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IE970_RS12115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IE970_RS12120	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IE970_RS12125	COG0456	acetyltransferase
IE970_RS12130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IE970_RS12135	COG2244	polysaccharide biosynthetic process
IE970_RS12180	COG3071	HemY protein
IE970_RS12185	COG2959	enzyme of heme biosynthesis
IE970_RS12190	COG1587	Uroporphyrinogen-III synthase
IE970_RS12200	COG3072	Adenylate cyclase
IE970_RS12220	COG1228	amidohydrolase
IE970_RS12230	COG5567	small periplasmic lipoprotein
IE970_RS12250	COG1011	Hydrolase
IE970_RS12255	COG0210	DNA helicase
IE970_RS12260	COG0598	Magnesium transport protein CorA
IE970_RS12270	COG2050	protein possibly involved in aromatic compounds catabolism
IE970_RS12285	COG1280	lysine exporter protein (LysE YggA)
IE970_RS12295	COG1280	lysine exporter protein (LysE YggA)
IE970_RS12300	COG2267	carboxylic ester hydrolase activity
IE970_RS12305	COG0561	phosphatase activity
IE970_RS12310	COG0697	spore germination
IE970_RS12315	COG0583	DNA-binding transcription factor activity
IE970_RS12330	COG0412	Dienelactone hydrolase
IE970_RS12350	COG3165	ubiquinone biosynthetic process from chorismate
IE970_RS12360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IE970_RS12370	COG0805	protein transport
IE970_RS12415	COG1739	Uncharacterized protein family UPF0029
IE970_RS12425	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IE970_RS12455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IE970_RS12460	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IE970_RS12460	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IE970_RS12495	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IE970_RS12500	COG0250	Participates in transcription elongation, termination and antitermination
IE970_RS12535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IE970_RS12540	COG1447	Phosphotransferase system cellobiose-specific component IIA
IE970_RS12550	COG3706	GGDEF domain
IE970_RS12555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IE970_RS12565	COG2104	thiamine diphosphate biosynthetic process
IE970_RS12570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IE970_RS12585	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IE970_RS12625	COG4191	Histidine kinase
IE970_RS12635	COG0151	Belongs to the GarS family
IE970_RS12675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IE970_RS12725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE970_RS12765	COG1187	pseudouridine synthase activity
IE970_RS12780	COG4650	regulator
IE970_RS12790	COG3541	Predicted nucleotidyltransferase
IE970_RS12795	COG0527	aspartate kinase activity
IE970_RS12805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IE970_RS12815	COG0251	oxidation-reduction process
IE970_RS12885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IE970_RS12895	COG0534	Mate efflux family protein
IE970_RS12900	COG3237	CsbD-like
IE970_RS12905	COG0735	belongs to the Fur family
IE970_RS12915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IE970_RS12930	COG0305	Participates in initiation and elongation during chromosome replication
IE970_RS12935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IE970_RS12940	COG1448	Aminotransferase
IE970_RS12950	COG0432	Pfam Uncharacterised protein family UPF0047
IE970_RS12955	COG2315	Protein conserved in bacteria
IE970_RS12970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IE970_RS12975	COG0629	single-stranded DNA binding
IE970_RS12980	COG0741	lytic transglycosylase activity
IE970_RS12985	COG4771	TonB-dependent receptor
IE970_RS12995	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE970_RS13010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IE970_RS13030	COG2252	PERMEase
IE970_RS13035	COG0025	NhaP-type Na H and K H
IE970_RS13040	COG0583	DNA-binding transcription factor activity
IE970_RS13045	COG1380	Effector of murein hydrolase LrgA
IE970_RS13050	COG1346	cytolysis
IE970_RS13060	COG3121	Chaperone
IE970_RS13090	COG3162	membrane
IE970_RS13095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IE970_RS13100	COG1301	dicarboxylic acid transport
IE970_RS13105	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IE970_RS13115	COG1940	carbohydrate kinase activity
IE970_RS13120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE970_RS13125	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS13130	COG1129	ABC transporter
IE970_RS13135	COG1879	ABC-type sugar transport system periplasmic component
IE970_RS13140	COG1737	Transcriptional regulator
IE970_RS13145	COG0698	ribose 5-phosphate isomerase
IE970_RS13155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IE970_RS13160	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IE970_RS13165	COG3454	Phosphonate metabolism
IE970_RS13170	COG4778	phosphonate C-P lyase system protein PhnL
IE970_RS13175	COG4107	phosphonate C-P lyase system protein PhnK
IE970_RS13180	COG3627	carbon phosphorus lyase activity
IE970_RS13185	COG3626	phosphonate metabolism
IE970_RS13190	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IE970_RS13195	COG3624	Phosphonate C-P lyase system protein PhnG
IE970_RS13200	COG2188	Transcriptional regulator
IE970_RS13205	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IE970_RS13210	COG2824	Alkylphosphonate utilization operon protein PhnA
IE970_RS13230	COG0861	Integral membrane protein TerC family
IE970_RS13245	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE970_RS13260	COG1216	Glycosyl transferase, family 2
IE970_RS13275	COG1309	transcriptional regulator
IE970_RS13290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IE970_RS13295	COG1027	Aspartate ammonia-lyase
IE970_RS13300	COG3030	protein affecting phage T7 exclusion by the F plasmid
IE970_RS13305	COG0531	amino acid
IE970_RS13315	COG0459	protein refolding
IE970_RS13355	COG3121	Chaperone
IE970_RS13370	COG1509	lysine 2,3-aminomutase activity
IE970_RS13390	COG2076	Multidrug Resistance protein
IE970_RS13395	COG3040	lipid binding
IE970_RS13410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IE970_RS13415	COG1053	succinate dehydrogenase
IE970_RS13430	COG1511	domain protein
IE970_RS13430	COG3264	Mechanosensitive ion channel
IE970_RS13445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IE970_RS13450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS13470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IE970_RS13475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IE970_RS13475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IE970_RS13480	COG0802	atpase or kinase
IE970_RS13485	COG0860	N-Acetylmuramoyl-L-alanine amidase
IE970_RS13505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IE970_RS13510	COG0330	HflC and HflK could
IE970_RS13515	COG0330	HflC and HflK could
IE970_RS13520	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IE970_RS13535	COG0557	exoribonuclease II activity
IE970_RS13540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE970_RS13550	COG1960	acyl-CoA dehydrogenase activity
IE970_RS13560	COG3650	response to hydrogen peroxide
IE970_RS13565	COG1073	alpha beta
IE970_RS13625	COG2965	DNA replication, synthesis of RNA primer
IE970_RS13630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IE970_RS13635	COG0359	binds to the 23S rRNA
IE970_RS13645	COG3061	Opacity-associated protein A
IE970_RS13650	COG0545	Peptidyl-prolyl cis-trans isomerase
IE970_RS13655	COG1113	amino acid transport
IE970_RS13665	COG0697	spore germination
IE970_RS13675	COG0702	epimerase
IE970_RS13680	COG1733	regulation of RNA biosynthetic process
IE970_RS13695	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IE970_RS13720	COG1253	flavin adenine dinucleotide binding
IE970_RS13730	COG0729	surface antigen
IE970_RS13735	COG2911	Protein conserved in bacteria
IE970_RS13740	COG2105	PFAM AIG2 family protein
IE970_RS13750	COG1879	ABC-type sugar transport system periplasmic component
IE970_RS13755	COG1129	ABC transporter
IE970_RS13760	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS13765	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS13775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IE970_RS13795	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS13805	COG0312	modulator of DNA gyrase
IE970_RS13840	COG3964	amidohydrolase
IE970_RS13855	COG2706	6-phosphogluconolactonase activity
IE970_RS13860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS13860	COG3711	transcriptional antiterminator
IE970_RS13865	COG0602	queuosine metabolic process
IE970_RS13885	COG1486	melibiose metabolic process
IE970_RS13890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS13895	COG0366	Alpha amylase catalytic
IE970_RS13900	COG1263	PTS System
IE970_RS13900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS13915	COG0251	oxidation-reduction process
IE970_RS13920	COG3397	chitin binding
IE970_RS13945	COG2731	YhcH YjgK YiaL family protein
IE970_RS13950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IE970_RS13975	COG0525	valine-tRNA ligase activity
IE970_RS13980	COG2927	DNA polymerase III (CHI subunit)
IE970_RS13990	COG0795	lipopolysaccharide-transporting ATPase activity
IE970_RS13995	COG0795	lipopolysaccharide-transporting ATPase activity
IE970_RS14000	COG0433	COG0433 Predicted ATPase
IE970_RS14015	COG3718	enzyme involved in inositol metabolism
IE970_RS14020	COG1737	Transcriptional regulator
IE970_RS14020	COG0837	glucose binding
IE970_RS14025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS14030	COG3962	Belongs to the TPP enzyme family
IE970_RS14040	COG1082	Xylose isomerase domain protein TIM barrel
IE970_RS14050	COG2814	Major facilitator Superfamily
IE970_RS14060	COG3842	ATPase activity
IE970_RS14065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IE970_RS14070	COG0395	ABC-type sugar transport system, permease component
IE970_RS14075	COG1175	transmembrane transport
IE970_RS14080	COG1064	alcohol dehydrogenase
IE970_RS14100	COG0582	viral genome integration into host DNA
IE970_RS14175	COG0326	Molecular chaperone. Has ATPase activity
IE970_RS14225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE970_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS14235	COG4948	Mandelate Racemase Muconate Lactonizing
IE970_RS14240	COG0477	Major facilitator Superfamily
IE970_RS14250	COG0477	Major facilitator Superfamily
IE970_RS14265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IE970_RS14270	COG2850	peptidyl-arginine hydroxylation
IE970_RS14300	COG0842	Transport permease protein
IE970_RS14305	COG0842	Transport permease protein
IE970_RS14305	COG1129	ABC transporter
IE970_RS14310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS14315	COG3706	GGDEF domain
IE970_RS14325	COG0814	amino acid
IE970_RS14355	COG4869	propanediol catabolic process
IE970_RS14365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IE970_RS14370	COG1882	Formate acetyltransferase
IE970_RS14385	COG1454	alcohol dehydrogenase
IE970_RS14385	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS14420	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE970_RS14445	COG0531	amino acid
IE970_RS14460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IE970_RS14465	COG0732	type I restriction modification DNA specificity domain
IE970_RS14470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IE970_RS14475	COG1715	Restriction endonuclease
IE970_RS14480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE970_RS14485	COG5457	Domain of unknown function (DUF1127)
IE970_RS14495	COG1566	PFAM secretion protein HlyD family protein
IE970_RS14505	COG0583	DNA-binding transcription factor activity
IE970_RS14510	COG3366	ferrous iron transmembrane transporter activity
IE970_RS14515	COG0700	Nucleoside recognition
IE970_RS14520	COG1473	amidohydrolase
IE970_RS14530	COG1924	4 iron, 4 sulfur cluster binding
IE970_RS14535	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IE970_RS14545	COG3969	phosphoadenosine phosphosulfate
IE970_RS14550	COG1475	DNA binding
IE970_RS14555	COG2814	Major facilitator Superfamily
IE970_RS14560	COG2733	membrane
IE970_RS14565	COG1280	lysine exporter protein (LysE YggA)
IE970_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS14595	COG0523	cobalamin synthesis protein
IE970_RS14600	COG2879	small protein
IE970_RS14605	COG1966	Carbon starvation protein
IE970_RS14610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE970_RS14615	COG2368	4-hydroxyphenylacetate
IE970_RS14635	COG3971	2-oxopent-4-enoate hydratase activity
IE970_RS14645	COG3384	dioxygenase
IE970_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS14660	COG0179	Fumarylacetoacetate (FAA) hydrolase
IE970_RS14665	COG1846	Transcriptional regulator
IE970_RS14675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IE970_RS14685	COG4145	pantothenate transmembrane transporter activity
IE970_RS14690	COG3734	2-keto-3-deoxy-galactonokinase
IE970_RS14695	COG0800	Aldolase
IE970_RS14700	COG1737	Transcriptional regulator
IE970_RS14710	COG0456	acetyltransferase
IE970_RS14715	COG2271	Major facilitator Superfamily
IE970_RS14720	COG1802	Transcriptional regulator
IE970_RS14725	COG1063	alcohol dehydrogenase
IE970_RS14735	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IE970_RS14735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IE970_RS14750	COG3715	PTS system
IE970_RS14755	COG3716	PTS system mannose fructose sorbose family IID component
IE970_RS14760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE970_RS14765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE970_RS14770	COG5464	transposase or invertase
IE970_RS14785	COG1484	DNA-dependent DNA replication
IE970_RS14800	COG2966	Psort location CytoplasmicMembrane, score
IE970_RS14810	COG2207	Transcriptional regulator
IE970_RS14815	COG2197	response regulator
IE970_RS14820	COG2197	response regulator
IE970_RS14825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IE970_RS14830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS14835	COG4114	ferric iron reductase
IE970_RS14840	COG3706	GGDEF domain
IE970_RS14870	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IE970_RS14875	COG0456	acetyltransferase
IE970_RS14880	COG1011	Hydrolase
IE970_RS14890	COG2823	Periplasmic or secreted lipoprotein
IE970_RS14895	COG5487	UPF0391 membrane protein
IE970_RS14900	COG4667	esterase of the alpha-beta hydrolase superfamily
IE970_RS14905	COG0084	hydrolase, TatD family'
IE970_RS14910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IE970_RS14930	COG0813	purine-nucleoside phosphorylase activity
IE970_RS14940	COG3726	membrane protein affecting hemolysin expression
IE970_RS14945	COG0560	Phosphoserine phosphatase
IE970_RS14960	COG0488	(ABC) transporter
IE970_RS14965	COG0741	lytic transglycosylase activity
IE970_RS14985	COG2207	Transcriptional regulator
IE970_RS14985	COG3708	Transcriptional regulator
IE970_RS14990	COG3045	CreA protein
IE970_RS14995	COG0745	RESPONSE REGULATOR receiver
IE970_RS15000	COG2205	protein histidine kinase activity
IE970_RS15005	COG4452	Inner membrane protein CreD
IE970_RS15010	COG0745	RESPONSE REGULATOR receiver
IE970_RS15020	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IE970_RS15030	COG0527	aspartate kinase activity
IE970_RS15030	COG0460	homoserine dehydrogenase
IE970_RS15040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IE970_RS15050	COG1115	amino acid carrier protein
IE970_RS15055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IE970_RS15060	COG0521	Mo-molybdopterin cofactor biosynthetic process
IE970_RS15065	COG0477	Major facilitator Superfamily
IE970_RS15070	COG1584	GPR1 FUN34 yaaH family protein
IE970_RS15075	COG4735	regulation of single-species biofilm formation
IE970_RS15135	COG0583	DNA-binding transcription factor activity
IE970_RS15145	COG0196	riboflavin kinase activity
IE970_RS15160	COG1047	Peptidyl-prolyl cis-trans
IE970_RS15175	COG0583	DNA-binding transcription factor activity
IE970_RS15180	COG2828	Protein conserved in bacteria
IE970_RS15185	COG0471	metal ion transport
IE970_RS15190	COG0471	metal ion transport
IE970_RS15195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IE970_RS15205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IE970_RS15330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IE970_RS15345	COG3493	citrate carrier protein
IE970_RS15355	COG0564	pseudouridine synthase activity
IE970_RS15365	COG0417	DNA replication proofreading
IE970_RS15370	COG0235	Class ii aldolase
IE970_RS15390	COG0586	Pfam SNARE associated Golgi protein
IE970_RS15400	COG1178	ABC-type Fe3 transport system permease component
IE970_RS15420	COG2814	Major facilitator Superfamily
IE970_RS15425	COG2271	Major facilitator Superfamily
IE970_RS15430	COG0583	DNA-binding transcription factor activity
IE970_RS15440	COG0738	Major facilitator superfamily
IE970_RS15445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE970_RS15470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IE970_RS15485	COG0028	Belongs to the TPP enzyme family
IE970_RS15495	COG1609	Transcriptional regulator
IE970_RS15515	COG0768	penicillin binding
IE970_RS15525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IE970_RS15540	COG0772	Belongs to the SEDS family
IE970_RS15565	COG0849	cell division
IE970_RS15570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IE970_RS15590	COG0494	nUDIX hydrolase
IE970_RS15595	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IE970_RS15615	COG1459	type II secretion system
IE970_RS15620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IE970_RS15625	COG4969	Belongs to the N-Me-Phe pilin family
IE970_RS15640	COG3725	Membrane protein required for beta-lactamase induction
IE970_RS15645	COG3940	Belongs to the glycosyl hydrolase 43 family
IE970_RS15650	COG2211	Major facilitator Superfamily
IE970_RS15655	COG1113	amino acid transport
IE970_RS15660	COG2186	Transcriptional regulator
IE970_RS15665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IE970_RS15670	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE970_RS15675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE970_RS15690	COG3064	Membrane
IE970_RS15720	COG1349	DNA-binding transcription factor activity
IE970_RS15735	COG0545	Peptidyl-prolyl cis-trans isomerase
IE970_RS15750	COG2132	Multicopper oxidase
IE970_RS15755	COG4993	Dehydrogenase
IE970_RS15765	COG0288	reversible hydration of carbon dioxide
IE970_RS15770	COG1131	(ABC) transporter
IE970_RS15775	COG0842	Transport permease protein
IE970_RS15780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS15785	COG0726	polysaccharide deacetylase
IE970_RS15810	COG3188	usher protein
IE970_RS15815	COG3121	Chaperone
IE970_RS15820	COG3539	Fimbrial protein
IE970_RS15840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IE970_RS15845	COG0617	tRNA 3'-terminal CCA addition
IE970_RS15865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IE970_RS15870	COG1643	Atp-dependent helicase
IE970_RS15955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IE970_RS15960	COG4774	siderophore transport
IE970_RS15965	COG1120	ATPase activity
IE970_RS15970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IE970_RS15975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS15980	COG5464	transposase or invertase
IE970_RS16000	COG2860	membrane
IE970_RS16020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE970_RS16025	COG3835	regulator
IE970_RS16045	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IE970_RS16055	COG0024	Methionine aminopeptidase
IE970_RS16065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IE970_RS16090	COG0575	Belongs to the CDS family
IE970_RS16095	COG0750	zinc metalloprotease
IE970_RS16105	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IE970_RS16110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE970_RS16150	COG1982	Orn Lys Arg decarboxylase major
IE970_RS16155	COG0346	lactoylglutathione lyase activity
IE970_RS16165	COG4568	rho-dependent transcription termination
IE970_RS16175	COG4681	YaeQ
IE970_RS16180	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IE970_RS16185	COG3015	lipoprotein NlpE involved in copper resistance
IE970_RS16190	COG0791	NLP P60 protein
IE970_RS16200	COG1720	tRNA m6t6A37 methyltransferase activity
IE970_RS16210	COG1464	Belongs to the NlpA lipoprotein family
IE970_RS16215	COG2011	ABC-type metal ion transport system permease component
IE970_RS16225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IE970_RS16265	COG0583	DNA-binding transcription factor activity
IE970_RS16270	COG2814	Major facilitator Superfamily
IE970_RS16280	COG2226	methyltransferase
IE970_RS16285	COG0741	lytic transglycosylase activity
IE970_RS16285	COG1388	LysM domain
IE970_RS16295	COG2226	methyltransferase
IE970_RS16315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE970_RS16330	COG0121	glutamine amidotransferase
IE970_RS16335	COG3034	peptidoglycan biosynthetic process
IE970_RS16350	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IE970_RS16355	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IE970_RS16370	COG2991	Protein conserved in bacteria
IE970_RS16385	COG0454	-acetyltransferase
IE970_RS16390	COG2195	Cleaves the N-terminal amino acid of tripeptides
IE970_RS16410	COG1045	serine acetyltransferase
IE970_RS16425	COG0438	transferase activity, transferring glycosyl groups
IE970_RS16425	COG0297	glycogen (starch) synthase activity
IE970_RS16430	COG0438	transferase activity, transferring glycosyl groups
IE970_RS16435	COG0463	Glycosyl transferase, family 2
IE970_RS16455	COG1596	polysaccharide export
IE970_RS16465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IE970_RS16470	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS16490	COG2186	Transcriptional regulator
IE970_RS16495	COG0246	Mannitol dehydrogenase
IE970_RS16510	COG3153	acetyltransferase
IE970_RS16515	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IE970_RS16535	COG0477	Major facilitator Superfamily
IE970_RS16545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE970_RS16555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IE970_RS16560	COG0402	S-adenosylhomocysteine deaminase activity
IE970_RS16565	COG2188	Transcriptional regulator
IE970_RS16575	COG2986	histidine ammonia-lyase
IE970_RS16605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IE970_RS16610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IE970_RS16625	COG2814	Major facilitator Superfamily
IE970_RS16640	COG1309	transcriptional regulator
IE970_RS16645	COG2171	N-acyltransferase activity
IE970_RS16705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IE970_RS16710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IE970_RS16715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE970_RS16720	COG0791	NLP P60 protein
IE970_RS16725	COG0583	DNA-binding transcription factor activity
IE970_RS16730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE970_RS16740	COG1116	anion transmembrane transporter activity
IE970_RS16765	COG3639	organic phosphonate transmembrane transporter activity
IE970_RS16775	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IE970_RS16800	COG3188	usher protein
IE970_RS16815	COG0765	amino acid transport
IE970_RS16820	COG0765	amino acid transport
IE970_RS16825	COG1126	abc transporter atp-binding protein
IE970_RS16830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS16865	COG4302	ethanolamine ammonia-lyase activity
IE970_RS16870	COG4303	Ethanolamine ammonia lyase large subunit
IE970_RS16880	COG5434	Belongs to the glycosyl hydrolase 28 family
IE970_RS16885	COG0833	amino acid
IE970_RS16890	COG2040	homocysteine
IE970_RS16895	COG3842	ATPase activity
IE970_RS16905	COG1840	ABC-type Fe3 transport system, periplasmic component
IE970_RS16910	COG2271	Major facilitator Superfamily
IE970_RS16925	COG4521	taurine ABC transporter
IE970_RS16930	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IE970_RS16935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE970_RS16940	COG2175	clavaminate synthase activity
IE970_RS16950	COG1943	Transposase
IE970_RS16955	COG0113	porphobilinogen synthase activity
IE970_RS16960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IE970_RS16970	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IE970_RS17005	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS17015	COG1609	Transcriptional regulator
IE970_RS17025	COG1785	Belongs to the alkaline phosphatase family
IE970_RS17035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IE970_RS17040	COG5301	cellulose 1,4-beta-cellobiosidase activity
IE970_RS17045	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IE970_RS17050	COG5301	cellulose 1,4-beta-cellobiosidase activity
IE970_RS17060	COG3299	homolog of phage Mu protein gp47
IE970_RS17090	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
IE970_RS17100	COG4386	tail sheath protein
IE970_RS17130	COG4397	Mu-like prophage major head subunit gpT
IE970_RS17155	COG4373	Mu-like prophage FluMu protein gp28
IE970_RS17170	COG0640	Transcriptional regulator
IE970_RS17210	COG4382	Mu-like prophage protein Gp16
IE970_RS17240	COG2842	Transposition protein
IE970_RS17250	COG3423	Transcriptional regulator
IE970_RS17265	COG3416	Protein conserved in bacteria
IE970_RS17270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IE970_RS17280	COG4126	flavin adenine dinucleotide binding
IE970_RS17295	COG1940	carbohydrate kinase activity
IE970_RS17305	COG0419	ATPase involved in DNA repair
IE970_RS17310	COG0420	3'-5' exonuclease activity
IE970_RS17335	COG0366	Alpha amylase catalytic
IE970_RS17340	COG0583	DNA-binding transcription factor activity
IE970_RS17345	COG1335	isochorismatase
IE970_RS17355	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IE970_RS17370	COG0450	alkyl hydroperoxide reductase
IE970_RS17375	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IE970_RS17390	COG1862	Preprotein translocase
IE970_RS17400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IE970_RS17425	COG4238	major outer membrane lipoprotein
IE970_RS17435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IE970_RS17435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IE970_RS17455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IE970_RS17460	COG0667	Aldo Keto reductase
IE970_RS17470	COG0142	geranyltranstransferase activity
IE970_RS17490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IE970_RS17500	COG2814	Major facilitator Superfamily
IE970_RS17505	COG0673	inositol 2-dehydrogenase activity
IE970_RS17510	COG2211	Major facilitator Superfamily
IE970_RS17535	COG1053	succinate dehydrogenase
IE970_RS17545	COG1414	Transcriptional regulator
IE970_RS17560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IE970_RS17565	COG1845	cytochrome c oxidase, subunit III
IE970_RS17570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IE970_RS17575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IE970_RS17580	COG2223	nitrite transmembrane transporter activity
IE970_RS17585	COG3056	Lipoprotein
IE970_RS17590	COG0271	Belongs to the BolA IbaG family
IE970_RS17610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IE970_RS17615	COG0776	regulation of translation
IE970_RS17620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE970_RS17625	COG1555	photosystem II stabilization
IE970_RS17630	COG0824	Thioesterase
IE970_RS17640	COG4533	DNA binding
IE970_RS17655	COG1522	sequence-specific DNA binding
IE970_RS17660	COG1132	(ABC) transporter
IE970_RS17665	COG1132	(ABC) transporter
IE970_RS17675	COG0347	Belongs to the P(II) protein family
IE970_RS17680	COG0004	ammonium transporteR
IE970_RS17685	COG1946	Acyl-CoA thioesterase
IE970_RS17690	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IE970_RS17695	COG3695	enzyme binding
IE970_RS17725	COG2364	Membrane
IE970_RS17730	COG5507	3-demethylubiquinone-9 3-methyltransferase
IE970_RS17745	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IE970_RS17755	COG2182	Extracellular solute-binding protein
IE970_RS17760	COG1175	transmembrane transport
IE970_RS17765	COG3833	ABC-type maltose transport systems, permease component
IE970_RS17770	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IE970_RS17775	COG1874	Beta-galactosidase
IE970_RS17780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS17780	COG1263	PTS System
IE970_RS17800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IE970_RS17820	COG0110	maltose O-acetyltransferase activity
IE970_RS17835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE970_RS17840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS17845	COG1309	transcriptional regulator
IE970_RS17850	COG3264	Mechanosensitive ion channel
IE970_RS17850	COG1196	nuclear chromosome segregation
IE970_RS17865	COG3923	Primosomal replication protein n
IE970_RS17870	COG2832	Protein of unknown function (DUF454)
IE970_RS17910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE970_RS17915	COG4651	solute:proton antiporter activity
IE970_RS17915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE970_RS17920	COG2223	nitrite transmembrane transporter activity
IE970_RS17930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IE970_RS17935	COG3735	TraB family
IE970_RS17955	COG0811	peptide transport
IE970_RS17985	COG1585	Membrane protein implicated in regulation of membrane protease activity
IE970_RS17990	COG0330	HflC and HflK could
IE970_RS17995	COG4619	ABC transporter
IE970_RS18000	COG0390	transport system, permease component
IE970_RS18005	COG3118	belongs to the thioredoxin family
IE970_RS18010	COG0300	oxidoreductase activity
IE970_RS18015	COG2755	lipolytic protein G-D-S-L family
IE970_RS18020	COG4181	ATPase activity
IE970_RS18025	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IE970_RS18060	COG3960	tartronate-semialdehyde synthase activity
IE970_RS18065	COG3622	Belongs to the hyi family
IE970_RS18070	COG2084	Dehydrogenase
IE970_RS18080	COG1953	Uracil, thiamine, allantoin
IE970_RS18090	COG2233	PERMEase
IE970_RS18095	COG1929	Belongs to the glycerate kinase type-1 family
IE970_RS18100	COG3257	ureidoglycine aminohydrolase activity
IE970_RS18105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE970_RS18110	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IE970_RS18115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IE970_RS18120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IE970_RS18130	COG0549	Belongs to the carbamate kinase family
IE970_RS18135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IE970_RS18140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IE970_RS18150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IE970_RS18160	COG2501	S4 domain
IE970_RS18175	COG0582	viral genome integration into host DNA
IE970_RS18225	COG0842	Transport permease protein
IE970_RS18230	COG1129	ABC transporter
IE970_RS18230	COG0842	Transport permease protein
IE970_RS18235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS18280	COG3539	Fimbrial protein
IE970_RS18335	COG3311	Transcriptional regulator
IE970_RS18345	COG4983	Phage plasmid primase, P4 family domain protein
IE970_RS18370	COG2003	Belongs to the UPF0758 family
IE970_RS18400	COG2808	Putative FMN-binding domain
IE970_RS18410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE970_RS18420	COG0583	DNA-binding transcription factor activity
IE970_RS18430	COG3710	Transcriptional regulator
IE970_RS18435	COG0531	amino acid
IE970_RS18445	COG3104	oligopeptide transport
IE970_RS18460	COG2367	Beta-lactamase
IE970_RS18470	COG0673	inositol 2-dehydrogenase activity
IE970_RS18485	COG1129	ABC transporter
IE970_RS18490	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS18495	COG1263	PTS System
IE970_RS18495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS18495	COG2190	(PTS) system
IE970_RS18500	COG2723	6-phospho-beta-galactosidase activity
IE970_RS18505	COG3711	transcriptional antiterminator
IE970_RS18535	COG1120	ATPase activity
IE970_RS18540	COG4139	cobalamin transport
IE970_RS18560	COG1473	amidohydrolase
IE970_RS18565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS18570	COG0667	Aldo Keto reductase
IE970_RS18580	COG1113	amino acid transport
IE970_RS18585	COG2211	Major facilitator Superfamily
IE970_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS18610	COG0583	DNA-binding transcription factor activity
IE970_RS18615	COG2771	luxR family
IE970_RS18630	COG3188	usher protein
IE970_RS18650	COG0494	nUDIX hydrolase
IE970_RS18660	COG0668	transmembrane transport
IE970_RS18665	COG0477	Major facilitator Superfamily
IE970_RS18675	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IE970_RS18675	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IE970_RS18680	COG2222	sugar isomerase
IE970_RS18685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE970_RS18690	COG3716	PTS system mannose fructose sorbose family IID component
IE970_RS18700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS18710	COG0778	Nitroreductase
IE970_RS18715	COG2315	Protein conserved in bacteria
IE970_RS18735	COG4774	siderophore transport
IE970_RS18765	COG3698	Phosphodiester glycosidase
IE970_RS18785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS18790	COG4608	Belongs to the ABC transporter superfamily
IE970_RS18795	COG0444	Belongs to the ABC transporter superfamily
IE970_RS18820	COG1280	lysine exporter protein (LysE YggA)
IE970_RS18835	COG0765	amino acid transport
IE970_RS18840	COG0765	amino acid transport
IE970_RS18850	COG4221	oxidoreductase activity
IE970_RS18855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE970_RS18860	COG4608	Belongs to the ABC transporter superfamily
IE970_RS18865	COG0444	Belongs to the ABC transporter superfamily
IE970_RS18870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS18875	COG0601	transmembrane transport
IE970_RS18905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IE970_RS18915	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS18925	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS18930	COG1129	ABC transporter
IE970_RS18940	COG1879	ABC-type sugar transport system periplasmic component
IE970_RS18945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IE970_RS18950	COG2390	Transcriptional regulator
IE970_RS18955	COG3959	Transketolase, thiamine diphosphate binding domain
IE970_RS18960	COG3958	Transketolase
IE970_RS18965	COG2977	Belongs to the P-Pant transferase superfamily
IE970_RS18970	COG4771	TonB-dependent receptor
IE970_RS18975	COG2382	esterase
IE970_RS18980	COG3251	PFAM MbtH domain protein
IE970_RS18985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IE970_RS18985	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IE970_RS18990	COG1120	ATPase activity
IE970_RS18995	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS19000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS19015	COG4592	Periplasmic binding protein
IE970_RS19020	COG1169	isochorismate synthase
IE970_RS19025	COG1021	2,3-dihydroxybenzoate-AMP ligase
IE970_RS19030	COG1535	isochorismatase
IE970_RS19030	COG3433	isochorismatase activity
IE970_RS19035	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS19045	COG1966	Carbon starvation protein
IE970_RS19050	COG2879	small protein
IE970_RS19065	COG0371	Dehydrogenase
IE970_RS19070	COG1129	ABC transporter
IE970_RS19075	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS19105	COG2271	Major facilitator Superfamily
IE970_RS19110	COG0483	inositol monophosphate 1-phosphatase activity
IE970_RS19120	COG0402	S-adenosylhomocysteine deaminase activity
IE970_RS19130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IE970_RS19145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE970_RS19155	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS19160	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS19165	COG1129	ABC transporter
IE970_RS19180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IE970_RS19185	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IE970_RS19190	COG0436	Aminotransferase
IE970_RS19195	COG1475	DNA binding
IE970_RS19200	COG3969	phosphoadenosine phosphosulfate
IE970_RS19205	COG0583	DNA-binding transcription factor activity
IE970_RS19215	COG3634	alkyl hydroperoxide reductase activity
IE970_RS19225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE970_RS19230	COG3719	Belongs to the RNase T2 family
IE970_RS19235	COG3069	C4-dicarboxylate transmembrane transporter activity
IE970_RS19255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE970_RS19260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IE970_RS19270	COG0583	DNA-binding transcription factor activity
IE970_RS19285	COG1686	Belongs to the peptidase S11 family
IE970_RS19290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IE970_RS19295	COG0772	Belongs to the SEDS family
IE970_RS19300	COG0768	penicillin binding
IE970_RS19310	COG0799	negative regulation of ribosome biogenesis
IE970_RS19325	COG1466	dna polymerase III delta subunit
IE970_RS19340	COG2888	peptidyl-tyrosine sulfation
IE970_RS19350	COG2831	hemolysin activation secretion protein
IE970_RS19355	COG1126	abc transporter atp-binding protein
IE970_RS19360	COG0765	amino acid transport
IE970_RS19365	COG0765	amino acid transport
IE970_RS19380	COG4535	Mg2 and Co2 transporter CorC
IE970_RS19385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IE970_RS19390	COG1702	phosphate starvation-inducible protein PhoH
IE970_RS19400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE970_RS19445	COG0367	asparagine synthase
IE970_RS19450	COG0647	UMP catabolic process
IE970_RS19455	COG1940	carbohydrate kinase activity
IE970_RS19455	COG1846	Transcriptional regulator
IE970_RS19460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IE970_RS19500	COG1053	succinate dehydrogenase
IE970_RS19510	COG0735	belongs to the Fur family
IE970_RS19525	COG0596	Alpha beta hydrolase
IE970_RS19530	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IE970_RS19535	COG0033	Phosphoglucomutase
IE970_RS19545	COG1349	DNA-binding transcription factor activity
IE970_RS19550	COG1063	alcohol dehydrogenase
IE970_RS19555	COG1879	ABC-type sugar transport system periplasmic component
IE970_RS19560	COG1129	ABC transporter
IE970_RS19565	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS19570	COG1070	Carbohydrate kinase
IE970_RS19575	COG3623	hexulose-6-phosphate isomerase
IE970_RS19585	COG0745	RESPONSE REGULATOR receiver
IE970_RS19590	COG2205	protein histidine kinase activity
IE970_RS19620	COG0415	Belongs to the DNA photolyase family
IE970_RS19630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IE970_RS19635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IE970_RS19640	COG1984	allophanate hydrolase subunit 2
IE970_RS19670	COG0372	Belongs to the citrate synthase family
IE970_RS19680	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IE970_RS19685	COG1053	succinate dehydrogenase
IE970_RS19690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IE970_RS19695	COG0567	Dehydrogenase, E1 component
IE970_RS19700	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE970_RS19710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IE970_RS19725	COG0583	DNA-binding transcription factor activity
IE970_RS19740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS19740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS19750	COG1301	dicarboxylic acid transport
IE970_RS19765	COG3799	methylaspartate ammonia-lyase activity
IE970_RS19770	COG4865	methylaspartate mutase activity
IE970_RS19780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IE970_RS19785	COG1271	oxidase subunit
IE970_RS19790	COG1294	oxidase, subunit
IE970_RS19795	COG4890	Cyd operon protein YbgT
IE970_RS19800	COG3790	cyd operon protein YbgE
IE970_RS19805	COG0824	Thioesterase
IE970_RS19810	COG0811	peptide transport
IE970_RS19815	COG0848	biopolymer transport protein
IE970_RS19820	COG3064	Membrane
IE970_RS19830	COG2885	chlorophyll binding
IE970_RS19835	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IE970_RS19865	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IE970_RS19885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IE970_RS19895	COG2017	converts alpha-aldose to the beta-anomer
IE970_RS19905	COG1085	galactose-1-phosphate uridylyltransferase
IE970_RS19910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IE970_RS19915	COG1119	ATPase activity
IE970_RS19920	COG2005	Transcriptional regulator
IE970_RS19920	COG3585	molybdate ion transport
IE970_RS19930	COG0725	ABC transporter, periplasmic molybdate-binding protein
IE970_RS19935	COG4149	molybdate abc transporter
IE970_RS19945	COG0561	phosphatase activity
IE970_RS19980	COG2200	EAL domain
IE970_RS19985	COG0789	Transcriptional regulator
IE970_RS20000	COG4677	pectinesterase activity
IE970_RS20035	COG1881	PFAM PEBP family protein
IE970_RS20040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE970_RS20055	COG2226	methyltransferase
IE970_RS20080	COG0745	RESPONSE REGULATOR receiver
IE970_RS20100	COG0521	Mo-molybdopterin cofactor biosynthetic process
IE970_RS20110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IE970_RS20115	COG0314	molybdopterin synthase activity
IE970_RS20120	COG0670	Belongs to the BI1 family
IE970_RS20125	COG0392	lysyltransferase activity
IE970_RS20130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IE970_RS20135	COG3568	Endonuclease Exonuclease Phosphatase
IE970_RS20145	COG0842	Transport permease protein
IE970_RS20150	COG0842	Transport permease protein
IE970_RS20155	COG1131	(ABC) transporter
IE970_RS20160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS20165	COG1309	transcriptional regulator
IE970_RS20170	COG0583	DNA-binding transcription factor activity
IE970_RS20175	COG2271	Major facilitator Superfamily
IE970_RS20180	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS20185	COG3959	Transketolase, thiamine diphosphate binding domain
IE970_RS20190	COG3958	Transketolase
IE970_RS20195	COG0513	Belongs to the DEAD box helicase family
IE970_RS20205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IE970_RS20215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IE970_RS20225	COG4774	siderophore transport
IE970_RS20240	COG0668	transmembrane transport
IE970_RS20250	COG1126	abc transporter atp-binding protein
IE970_RS20255	COG0765	amino acid transport
IE970_RS20260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS20275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IE970_RS20280	COG2194	sulfuric ester hydrolase activity
IE970_RS20295	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IE970_RS20300	COG0667	Aldo Keto reductase
IE970_RS20305	COG2723	6-phospho-beta-galactosidase activity
IE970_RS20310	COG2188	Transcriptional regulator
IE970_RS20315	COG1376	ErfK ybiS ycfS ynhG family protein
IE970_RS20325	COG0488	(ABC) transporter
IE970_RS20340	COG2271	Major facilitator Superfamily
IE970_RS20345	COG1609	Transcriptional regulator
IE970_RS20355	COG0561	phosphatase activity
IE970_RS20360	COG1882	Formate acetyltransferase
IE970_RS20365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IE970_RS20370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IE970_RS20375	COG0303	'Molybdopterin
IE970_RS20380	COG1446	asparaginase
IE970_RS20390	COG0747	negative chemotaxis
IE970_RS20425	COG2133	pyrroloquinoline quinone binding
IE970_RS20430	COG0625	glutathione transferase activity
IE970_RS20435	COG0582	viral genome integration into host DNA
IE970_RS20465	COG1396	sequence-specific DNA binding
IE970_RS20485	COG1846	Transcriptional regulator
IE970_RS20545	COG4725	Belongs to the MT-A70-like family
IE970_RS20615	COG0740	serine-type endopeptidase activity
IE970_RS20655	COG1196	nuclear chromosome segregation
IE970_RS20690	COG1686	Belongs to the peptidase S11 family
IE970_RS20695	COG1349	DNA-binding transcription factor activity
IE970_RS20700	COG0671	phosphoesterase, PA-phosphatase related
IE970_RS20705	COG2814	Major facilitator Superfamily
IE970_RS20710	COG0561	phosphatase activity
IE970_RS20715	COG0738	Major facilitator superfamily
IE970_RS20720	COG3226	Transcriptional regulator
IE970_RS20745	COG0778	Nitroreductase
IE970_RS20760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IE970_RS20765	COG3842	ATPase activity
IE970_RS20770	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE970_RS20775	COG1177	transmembrane transport
IE970_RS20790	COG0745	RESPONSE REGULATOR receiver
IE970_RS20795	COG5002	protein histidine kinase activity
IE970_RS20800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS20805	COG4160	amino acid transport
IE970_RS20810	COG4215	(ABC) transporter
IE970_RS20815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS20820	COG1126	abc transporter atp-binding protein
IE970_RS20830	COG0393	Putative heavy-metal-binding
IE970_RS20835	COG3023	N-Acetylmuramoyl-L-alanine amidase
IE970_RS20840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE970_RS20845	COG0702	epimerase
IE970_RS20850	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IE970_RS20855	COG0028	Belongs to the TPP enzyme family
IE970_RS20865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE970_RS20875	COG2431	L-lysine efflux transmembrane transporter activity
IE970_RS20880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IE970_RS20885	COG3593	DNA synthesis involved in DNA repair
IE970_RS20890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS20900	COG1278	Cold shock
IE970_RS20910	COG0542	response to heat
IE970_RS20915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IE970_RS20925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IE970_RS20930	COG4988	ABC transporter
IE970_RS20935	COG0492	ferredoxin-NADP+ reductase activity
IE970_RS20945	COG1674	ftsk spoiiie
IE970_RS20945	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IE970_RS20955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IE970_RS20965	COG0243	molybdopterin cofactor binding
IE970_RS20970	COG0437	4 iron, 4 sulfur cluster binding
IE970_RS20975	COG3302	dmso reductase anchor subunit
IE970_RS20980	COG0477	Major facilitator Superfamily
IE970_RS20985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS20990	COG3958	Transketolase
IE970_RS20995	COG3959	Transketolase, thiamine diphosphate binding domain
IE970_RS21015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IE970_RS21020	COG1882	Formate acetyltransferase
IE970_RS21025	COG2116	formate transmembrane transporter activity
IE970_RS21030	COG1944	ATP diphosphatase activity
IE970_RS21035	COG2323	membrane
IE970_RS21055	COG0539	negative regulation of cytoplasmic translation
IE970_RS21065	COG0658	competence protein
IE970_RS21065	COG2333	competence protein COMEC
IE970_RS21070	COG1132	(ABC) transporter
IE970_RS21080	COG3214	Protein conserved in bacteria
IE970_RS21095	COG3173	Aminoglycoside phosphotransferase
IE970_RS21100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IE970_RS21105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IE970_RS21115	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IE970_RS21125	COG2989	Protein conserved in bacteria
IE970_RS21130	COG3108	Peptidase M15
IE970_RS21135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE970_RS21140	COG1448	Aminotransferase
IE970_RS21145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE970_RS21160	COG0308	aminopeptidase N
IE970_RS21165	COG1116	anion transmembrane transporter activity
IE970_RS21170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE970_RS21175	COG0431	NADPH-dependent FMN reductase
IE970_RS21190	COG0633	Ferredoxin
IE970_RS21190	COG3217	Mosc domain protein beta barrel domain protein
IE970_RS21200	COG0488	(ABC) transporter
IE970_RS21205	COG2995	paraquat-inducible protein a
IE970_RS21210	COG3008	intermembrane lipid transfer
IE970_RS21210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IE970_RS21215	COG3009	Protein conserved in bacteria
IE970_RS21220	COG3130	regulation of translation
IE970_RS21230	COG1067	ATP-dependent peptidase activity
IE970_RS21250	COG3070	regulator of competence-specific genes
IE970_RS21255	COG1289	transmembrane transporter activity
IE970_RS21260	COG3304	Inner membrane component domain
IE970_RS21265	COG0210	DNA helicase
IE970_RS21275	COG1832	CoA-binding protein
IE970_RS21300	COG2274	protein secretion by the type I secretion system
IE970_RS21305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS21310	COG0438	transferase activity, transferring glycosyl groups
IE970_RS21335	COG1881	PFAM PEBP family protein
IE970_RS21340	COG2207	Transcriptional regulator
IE970_RS21355	COG0670	Belongs to the BI1 family
IE970_RS21380	COG4821	SIS domain
IE970_RS21390	COG4821	SIS domain
IE970_RS21395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS21400	COG3716	PTS system mannose fructose sorbose family IID component
IE970_RS21405	COG3715	PTS system
IE970_RS21415	COG2188	Transcriptional regulator
IE970_RS21420	COG0436	Aminotransferase
IE970_RS21425	COG0504	CTP synthase activity
IE970_RS21430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE970_RS21435	COG0006	proline dipeptidase activity
IE970_RS21450	COG1126	abc transporter atp-binding protein
IE970_RS21455	COG0765	amino acid transport
IE970_RS21460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS21470	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS21485	COG2207	Transcriptional regulator
IE970_RS21490	COG1486	melibiose metabolic process
IE970_RS21520	COG0156	8-amino-7-oxononanoate synthase activity
IE970_RS21550	COG1126	abc transporter atp-binding protein
IE970_RS21555	COG0765	amino acid transport
IE970_RS21575	COG1278	Cold shock
IE970_RS21580	COG1278	Cold shock
IE970_RS21585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE970_RS21595	COG0745	RESPONSE REGULATOR receiver
IE970_RS21600	COG5002	protein histidine kinase activity
IE970_RS21615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS21625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IE970_RS21685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE970_RS21690	COG2233	PERMEase
IE970_RS21700	COG2351	hydroxyisourate hydrolase activity
IE970_RS21705	COG0402	S-adenosylhomocysteine deaminase activity
IE970_RS21710	COG1953	Uracil, thiamine, allantoin
IE970_RS21765	COG0765	amino acid transport
IE970_RS21775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IE970_RS21790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IE970_RS21800	COG1605	Chorismate mutase
IE970_RS21800	COG0287	Prephenate dehydrogenase
IE970_RS21815	COG3706	GGDEF domain
IE970_RS21820	COG2207	Transcriptional regulator
IE970_RS21830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS21835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IE970_RS21840	COG1882	Formate acetyltransferase
IE970_RS21845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS21850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE970_RS21855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS21855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS21855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IE970_RS21860	COG0473	3-isopropylmalate dehydrogenase activity
IE970_RS21865	COG0583	DNA-binding transcription factor activity
IE970_RS21870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE970_RS21875	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS21880	COG1396	sequence-specific DNA binding
IE970_RS21880	COG1917	Cupin 2, conserved barrel domain protein
IE970_RS21885	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IE970_RS21890	COG0174	glutamine synthetase
IE970_RS21895	COG0531	amino acid
IE970_RS21915	COG4974	Belongs to the 'phage' integrase family
IE970_RS21985	COG4695	Portal protein
IE970_RS22135	COG3729	General stress protein
IE970_RS22140	COG2233	PERMEase
IE970_RS22175	COG1309	transcriptional regulator
IE970_RS22190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IE970_RS22200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IE970_RS22210	COG2822	iron ion transport
IE970_RS22220	COG1702	phosphate starvation-inducible protein PhoH
IE970_RS22240	COG5002	protein histidine kinase activity
IE970_RS22240	COG3850	Histidine kinase
IE970_RS22260	COG1335	isochorismatase
IE970_RS22270	COG0583	DNA-binding transcription factor activity
IE970_RS22290	COG3381	protein complex oligomerization
IE970_RS22330	COG5645	(Lipo)protein
IE970_RS22345	COG1560	Kdo2-lipid A biosynthetic process
IE970_RS22385	COG2999	glutathione oxidoreductase activity
IE970_RS22400	COG2801	Transposase and inactivated derivatives
IE970_RS22410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE970_RS22420	COG0673	inositol 2-dehydrogenase activity
IE970_RS22430	COG2814	Major facilitator Superfamily
IE970_RS22435	COG0583	DNA-binding transcription factor activity
IE970_RS22440	COG1530	ribonuclease E activity
IE970_RS22455	COG0424	maF-like protein
IE970_RS22460	COG1399	metal-binding, possibly nucleic acid-binding protein
IE970_RS22480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IE970_RS22495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE970_RS22500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IE970_RS22505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IE970_RS22515	COG0470	DNA polymerase III
IE970_RS22520	COG0084	hydrolase, TatD family'
IE970_RS22530	COG4773	Receptor
IE970_RS22535	COG0537	adenosine 5'-monophosphoramidase activity
IE970_RS22540	COG5633	Lipoprotein
IE970_RS22565	COG1252	NADH dehydrogenase
IE970_RS22570	COG3134	Outer membrane lipoprotein
IE970_RS22580	COG1309	transcriptional regulator
IE970_RS22590	COG1388	LysM domain
IE970_RS22590	COG1376	ErfK ybiS ycfS ynhG family protein
IE970_RS22595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IE970_RS22600	COG4591	ABC-type transport system involved in lipoprotein release permease component
IE970_RS22605	COG1136	(ABC) transporter
IE970_RS22610	COG4591	ABC-type transport system involved in lipoprotein release permease component
IE970_RS22620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IE970_RS22625	COG2390	Transcriptional regulator
IE970_RS22640	COG3395	kinase activity
IE970_RS22655	COG0698	ribose 5-phosphate isomerase
IE970_RS22660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IE970_RS22665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IE970_RS22680	COG1177	transmembrane transport
IE970_RS22700	COG2850	peptidyl-arginine hydroxylation
IE970_RS22705	COG2205	protein histidine kinase activity
IE970_RS22710	COG0745	RESPONSE REGULATOR receiver
IE970_RS22720	COG2814	Major facilitator Superfamily
IE970_RS22725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IE970_RS22745	COG1187	pseudouridine synthase activity
IE970_RS22750	COG0538	isocitrate dehydrogenase activity
IE970_RS22780	COG0583	DNA-binding transcription factor activity
IE970_RS22785	COG3706	GGDEF domain
IE970_RS22790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IE970_RS22800	COG1120	ATPase activity
IE970_RS22805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS22810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS22815	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IE970_RS22820	COG4772	TonB-dependent receptor
IE970_RS22825	COG3712	iron ion homeostasis
IE970_RS22830	COG1595	DNA-templated transcription, initiation
IE970_RS22835	COG2226	methyltransferase
IE970_RS22840	COG1560	Kdo2-lipid A biosynthetic process
IE970_RS22850	COG3182	Iron-regulated membrane protein
IE970_RS22870	COG2203	Gaf domain
IE970_RS22870	COG2199	diguanylate cyclase activity
IE970_RS22875	COG3042	response to heat
IE970_RS22880	COG3189	MarR family transcriptional regulator
IE970_RS22885	COG1683	Conserved Protein
IE970_RS22890	COG0504	CTP synthase activity
IE970_RS22895	COG2807	transmembrane transport
IE970_RS22900	COG2207	Transcriptional regulator
IE970_RS22910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IE970_RS22915	COG2199	diguanylate cyclase activity
IE970_RS22920	COG0859	PFAM glycosyl transferase family 9
IE970_RS22930	COG2766	serine protein kinase
IE970_RS22935	COG3713	MltA-interacting MipA family protein
IE970_RS22940	COG0656	L-ascorbic acid biosynthetic process
IE970_RS22960	COG3139	Protein of unknown function (DUF1315)
IE970_RS22980	COG1335	isochorismatase
IE970_RS22985	COG0252	asparaginase activity
IE970_RS22990	COG0616	signal peptide processing
IE970_RS22995	COG0778	Nitroreductase
IE970_RS23005	COG0709	Synthesizes selenophosphate from selenide and ATP
IE970_RS23010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IE970_RS23020	COG0494	nUDIX hydrolase
IE970_RS23025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IE970_RS23030	COG2897	thiosulfate sulfurtransferase activity
IE970_RS23035	COG4136	ATPase activity
IE970_RS23040	COG4135	transport system, permease component
IE970_RS23045	COG4134	Bacterial extracellular solute-binding protein
IE970_RS23050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS23055	COG0398	Pfam SNARE associated Golgi protein
IE970_RS23060	COG0398	Pfam SNARE associated Golgi protein
IE970_RS23065	COG0708	Exodeoxyribonuclease III
IE970_RS23075	COG3138	arginine N-succinyltransferase
IE970_RS23095	COG3678	ATP-independent chaperone mediated protein folding
IE970_RS23100	COG1704	LemA family
IE970_RS23105	COG4907	membrane protein (DUF2207)
IE970_RS23110	COG0322	excinuclease ABC activity
IE970_RS23120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE970_RS23125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS23130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS23135	COG1447	Phosphotransferase system cellobiose-specific component IIA
IE970_RS23140	COG2169	Transcriptional regulator
IE970_RS23140	COG1917	Cupin 2, conserved barrel domain protein
IE970_RS23145	COG1486	melibiose metabolic process
IE970_RS23155	COG0753	catalase activity
IE970_RS23165	COG1823	symporter activity
IE970_RS23170	COG1988	membrane-bound metal-dependent
IE970_RS23175	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS23180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE970_RS23200	COG0038	chloride channel
IE970_RS23215	COG3047	cAMP biosynthetic process
IE970_RS23230	COG0583	DNA-binding transcription factor activity
IE970_RS23255	COG0135	phosphoribosylanthranilate isomerase activity
IE970_RS23255	COG0134	indole-3-glycerol-phosphate synthase activity
IE970_RS23260	COG0512	Glutamine amidotransferase of anthranilate synthase
IE970_RS23260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IE970_RS23265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IE970_RS23275	COG0009	L-threonylcarbamoyladenylate synthase
IE970_RS23280	COG1187	pseudouridine synthase activity
IE970_RS23285	COG2211	Major facilitator Superfamily
IE970_RS23290	COG1472	Belongs to the glycosyl hydrolase 3 family
IE970_RS23295	COG2207	Transcriptional regulator
IE970_RS23305	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS23310	COG0616	signal peptide processing
IE970_RS23335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IE970_RS23345	COG0671	phosphoesterase, PA-phosphatase related
IE970_RS23350	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IE970_RS23355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IE970_RS23365	COG0023	Translation Initiation Factor
IE970_RS23375	COG1349	DNA-binding transcription factor activity
IE970_RS23390	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS23390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS23395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IE970_RS23400	COG4172	Belongs to the ABC transporter superfamily
IE970_RS23410	COG4171	peptide transport system, permease
IE970_RS23420	COG4166	transmembrane transport
IE970_RS23435	COG1473	amidohydrolase
IE970_RS23445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IE970_RS23450	COG1842	Phage shock protein A
IE970_RS23460	COG1983	PspC domain protein
IE970_RS23470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IE970_RS23475	COG3106	COG3106 Predicted ATPase
IE970_RS23490	COG3180	Ammonia monooxygenase
IE970_RS23495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IE970_RS23500	COG4948	Mandelate Racemase Muconate Lactonizing
IE970_RS23505	COG2866	Carboxypeptidase
IE970_RS23510	COG4166	transmembrane transport
IE970_RS23525	COG2011	ABC-type metal ion transport system permease component
IE970_RS23530	COG1464	Belongs to the NlpA lipoprotein family
IE970_RS23535	COG0477	Major facilitator Superfamily
IE970_RS23550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE970_RS23565	COG2188	Transcriptional regulator
IE970_RS23570	COG0511	ligase activity, forming carbon-carbon bonds
IE970_RS23575	COG0439	Biotin carboxylase
IE970_RS23580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IE970_RS23585	COG0697	spore germination
IE970_RS23595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IE970_RS23600	COG1984	allophanate hydrolase subunit 2
IE970_RS23605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IE970_RS23610	COG0436	Aminotransferase
IE970_RS23625	COG4221	oxidoreductase activity
IE970_RS23630	COG0765	amino acid transport
IE970_RS23635	COG0765	amino acid transport
IE970_RS23645	COG1605	Chorismate mutase
IE970_RS23650	COG0693	protein deglycase activity
IE970_RS23745	COG3507	Belongs to the glycosyl hydrolase 43 family
IE970_RS23750	COG2211	Major facilitator Superfamily
IE970_RS23755	COG4580	involved in the transport of maltose and maltodextrins
IE970_RS23760	COG3272	Protein of unknown function (DUF1722)
IE970_RS23770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IE970_RS23785	COG0300	oxidoreductase activity
IE970_RS23795	COG0789	Transcriptional regulator
IE970_RS23820	COG0583	DNA-binding transcription factor activity
IE970_RS23830	COG0300	oxidoreductase activity
IE970_RS23850	COG2885	chlorophyll binding
IE970_RS23850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IE970_RS23855	COG3477	response to acidic pH
IE970_RS23875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE970_RS23880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE970_RS23885	COG0673	inositol 2-dehydrogenase activity
IE970_RS23890	COG1349	DNA-binding transcription factor activity
IE970_RS23905	COG0513	Belongs to the DEAD box helicase family
IE970_RS23925	COG0589	response to stress
IE970_RS23935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE970_RS23940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE970_RS23940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IE970_RS23940	COG1013	pyruvate-flavodoxin oxidoreductase activity
IE970_RS23940	COG0674	pyruvate-flavodoxin oxidoreductase activity
IE970_RS24020	COG3042	response to heat
IE970_RS24025	COG3187	Heat shock protein
IE970_RS24030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE970_RS24035	COG0586	Pfam SNARE associated Golgi protein
IE970_RS24040	COG2911	Protein conserved in bacteria
IE970_RS24050	COG3784	Protein of unknown function (DUF1318)
IE970_RS24055	COG2207	Transcriptional regulator
IE970_RS24060	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS24075	COG5285	phytanoyl-CoA dioxygenase
IE970_RS24080	COG1126	abc transporter atp-binding protein
IE970_RS24085	COG0583	DNA-binding transcription factor activity
IE970_RS24090	COG2072	flavoprotein involved in K transport
IE970_RS24120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IE970_RS24145	COG1566	PFAM secretion protein HlyD family protein
IE970_RS24160	COG2207	Transcriptional regulator
IE970_RS24165	COG2207	Transcriptional regulator
IE970_RS24165	COG3708	Transcriptional regulator
IE970_RS24170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS24185	COG0406	alpha-ribazole phosphatase activity
IE970_RS24190	COG2378	regulation of single-species biofilm formation
IE970_RS24195	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS24205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE970_RS24210	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IE970_RS24235	COG0583	DNA-binding transcription factor activity
IE970_RS24250	COG3813	Protein conserved in bacteria
IE970_RS24270	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS24270	COG2030	dehydratase
IE970_RS24275	COG3396	Phenylacetate-CoA oxygenase
IE970_RS24280	COG3460	Phenylacetate-CoA oxygenase
IE970_RS24285	COG3396	Phenylacetate-CoA oxygenase
IE970_RS24290	COG2151	metal-sulfur cluster biosynthetic enzyme
IE970_RS24295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE970_RS24300	COG1024	Enoyl-CoA hydratase
IE970_RS24305	COG1024	Enoyl-CoA hydratase
IE970_RS24310	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE970_RS24315	COG2050	protein possibly involved in aromatic compounds catabolism
IE970_RS24320	COG0183	Belongs to the thiolase family
IE970_RS24325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IE970_RS24330	COG3327	negative regulation of DNA-templated transcription, initiation
IE970_RS24335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IE970_RS24350	COG1643	Atp-dependent helicase
IE970_RS24355	COG4122	O-methyltransferase activity
IE970_RS24360	COG1538	Outer membrane efflux protein
IE970_RS24380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IE970_RS24385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IE970_RS24390	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS24395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IE970_RS24400	COG0456	acetyltransferase
IE970_RS24405	COG0583	DNA-binding transcription factor activity
IE970_RS24410	COG3706	GGDEF domain
IE970_RS24435	COG3038	cytochrome b561
IE970_RS24460	COG0583	DNA-binding transcription factor activity
IE970_RS24465	COG3485	protocatechuate 3,4-dioxygenase
IE970_RS24470	COG3485	protocatechuate 3,4-dioxygenase
IE970_RS24475	COG5383	Protein conserved in bacteria
IE970_RS24480	COG2272	Belongs to the type-B carboxylesterase lipase family
IE970_RS24490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE970_RS24495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IE970_RS24500	COG1275	C4-dicarboxylate transporter malic acid transport protein
IE970_RS24505	COG0500	methyltransferase
IE970_RS24510	COG2195	Cleaves the N-terminal amino acid of tripeptides
IE970_RS24515	COG0747	negative chemotaxis
IE970_RS24525	COG0697	spore germination
IE970_RS24530	COG2207	Transcriptional regulator
IE970_RS24535	COG3135	benzoate transporter
IE970_RS24540	COG1396	sequence-specific DNA binding
IE970_RS24545	COG0826	peptidase U32
IE970_RS24560	COG1294	oxidase, subunit
IE970_RS24565	COG1271	oxidase subunit
IE970_RS24570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE970_RS24575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IE970_RS24580	COG3842	ATPase activity
IE970_RS24585	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE970_RS24600	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS24625	COG0596	Alpha beta hydrolase
IE970_RS24630	COG4677	pectinesterase activity
IE970_RS24635	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS24640	COG0747	negative chemotaxis
IE970_RS24650	COG3238	Protein conserved in bacteria
IE970_RS24655	COG1247	-acetyltransferase
IE970_RS24670	COG2130	NADP-dependent
IE970_RS24680	COG3691	Protein conserved in bacteria
IE970_RS24685	COG4772	TonB-dependent receptor
IE970_RS24710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS24715	COG1473	amidohydrolase
IE970_RS24720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS24725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS24740	COG1126	abc transporter atp-binding protein
IE970_RS24750	COG2271	Major facilitator Superfamily
IE970_RS24760	COG1609	Transcriptional regulator
IE970_RS24765	COG0625	glutathione transferase activity
IE970_RS24790	COG2211	Major facilitator Superfamily
IE970_RS24800	COG4977	sequence-specific DNA binding
IE970_RS24805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE970_RS24810	COG3842	ATPase activity
IE970_RS24815	COG1840	ABC-type Fe3 transport system, periplasmic component
IE970_RS24820	COG1178	ABC-type Fe3 transport system permease component
IE970_RS24825	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IE970_RS24830	COG2181	nitrate reductase activity
IE970_RS24835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IE970_RS24840	COG1140	nitrate reductase beta subunit
IE970_RS24845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IE970_RS24865	COG0697	spore germination
IE970_RS24875	COG0437	4 iron, 4 sulfur cluster binding
IE970_RS24880	COG2864	formate dehydrogenase
IE970_RS24895	COG2814	Major facilitator Superfamily
IE970_RS24905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS24915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS24935	COG1064	alcohol dehydrogenase
IE970_RS24955	COG0488	(ABC) transporter
IE970_RS24985	COG1764	response to oxidative stress
IE970_RS25000	COG3781	membrane
IE970_RS25005	COG0243	molybdopterin cofactor binding
IE970_RS25010	COG1280	lysine exporter protein (LysE YggA)
IE970_RS25020	COG0583	DNA-binding transcription factor activity
IE970_RS25025	COG0583	DNA-binding transcription factor activity
IE970_RS25035	COG2271	Major facilitator Superfamily
IE970_RS25080	COG1280	lysine exporter protein (LysE YggA)
IE970_RS25105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE970_RS25105	COG1116	anion transmembrane transporter activity
IE970_RS25120	COG0439	Biotin carboxylase
IE970_RS25135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IE970_RS25135	COG0519	Catalyzes the synthesis of GMP from XMP
IE970_RS25150	COG0076	glutamate decarboxylase activity
IE970_RS25155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IE970_RS25160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE970_RS25165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE970_RS25170	COG1116	anion transmembrane transporter activity
IE970_RS25175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IE970_RS25180	COG0673	inositol 2-dehydrogenase activity
IE970_RS25185	COG1082	Xylose isomerase domain protein TIM barrel
IE970_RS25190	COG1609	Transcriptional regulator
IE970_RS25220	COG1649	PFAM Uncharacterised BCR, COG1649
IE970_RS25225	COG2200	EAL domain
IE970_RS25225	COG2771	luxR family
IE970_RS25230	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IE970_RS25240	COG0401	homolog of Blt101
IE970_RS25250	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS25260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IE970_RS25275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE970_RS25280	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE970_RS25285	COG0022	dehydrogenase e1 component
IE970_RS25290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IE970_RS25300	COG4977	sequence-specific DNA binding
IE970_RS25400	COG1760	l-serine dehydratase
IE970_RS25405	COG0814	amino acid
IE970_RS25435	COG2814	Major facilitator Superfamily
IE970_RS25440	COG1132	(ABC) transporter
IE970_RS25445	COG2375	cellular response to nickel ion
IE970_RS25445	COG1132	(ABC) transporter
IE970_RS25455	COG3433	isochorismatase activity
IE970_RS25455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IE970_RS25455	COG2226	methyltransferase
IE970_RS25475	COG1021	2,3-dihydroxybenzoate-AMP ligase
IE970_RS25480	COG4771	TonB-dependent receptor
IE970_RS25485	COG1652	LysM domain
IE970_RS25515	COG1609	Transcriptional regulator
IE970_RS25525	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS25540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE970_RS25550	COG4771	TonB-dependent receptor
IE970_RS25555	COG3391	amine dehydrogenase activity
IE970_RS25585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE970_RS25635	COG4821	SIS domain
IE970_RS25650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS25675	COG2841	Protein conserved in bacteria
IE970_RS25700	COG0583	DNA-binding transcription factor activity
IE970_RS25705	COG0412	Dienelactone hydrolase
IE970_RS25720	COG0693	protein deglycase activity
IE970_RS25730	COG1609	Transcriptional regulator
IE970_RS25740	COG1129	ABC transporter
IE970_RS25745	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS25775	COG1070	Carbohydrate kinase
IE970_RS25780	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS25785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE970_RS25790	COG3775	system Galactitol-specific IIC component
IE970_RS25810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS25815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IE970_RS25820	COG1120	ATPase activity
IE970_RS25835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE970_RS25840	COG1446	asparaginase
IE970_RS25845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IE970_RS25860	COG2207	Transcriptional regulator
IE970_RS25865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IE970_RS25885	COG0765	amino acid transport
IE970_RS25890	COG0765	amino acid transport
IE970_RS25895	COG1126	abc transporter atp-binding protein
IE970_RS25910	COG4628	conserved protein (DUF2132)
IE970_RS25930	COG2011	ABC-type metal ion transport system permease component
IE970_RS25945	COG0477	Major facilitator Superfamily
IE970_RS25980	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE970_RS25985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS26030	COG2199	diguanylate cyclase activity
IE970_RS26045	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS26050	COG0583	DNA-binding transcription factor activity
IE970_RS26060	COG0039	L-malate dehydrogenase activity
IE970_RS26100	COG0697	spore germination
IE970_RS26105	COG2814	Major facilitator Superfamily
IE970_RS26120	COG1129	ABC transporter
IE970_RS26140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IE970_RS26185	COG2200	EAL domain
IE970_RS26205	COG2223	nitrite transmembrane transporter activity
IE970_RS26210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IE970_RS26235	COG3122	Protein conserved in bacteria
IE970_RS26265	COG0339	signal peptide processing
IE970_RS26270	COG4221	oxidoreductase activity
IE970_RS26275	COG1802	Transcriptional regulator
IE970_RS26280	COG0589	response to stress
IE970_RS26285	COG0246	Mannitol dehydrogenase
IE970_RS26295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE970_RS26305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE970_RS26620	COG0582	viral genome integration into host DNA
IE970_RS26625	COG1063	alcohol dehydrogenase
IE970_RS26630	COG4948	Mandelate Racemase Muconate Lactonizing
IE970_RS26645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE970_RS26660	COG0243	molybdopterin cofactor binding
IE970_RS26665	COG0437	4 iron, 4 sulfur cluster binding
IE970_RS26670	COG3302	dmso reductase anchor subunit
IE970_RS26675	COG3381	protein complex oligomerization
IE970_RS26685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IE970_RS26690	COG1940	carbohydrate kinase activity
IE970_RS26695	COG0583	DNA-binding transcription factor activity
IE970_RS26700	COG2814	Major facilitator Superfamily
IE970_RS26705	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IE970_RS26720	COG3591	Belongs to the peptidase S1B family
IE970_RS26740	COG0628	permease
IE970_RS26770	COG0679	Auxin Efflux Carrier
IE970_RS26780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IE970_RS26795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IE970_RS26800	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS26810	COG3290	protein histidine kinase activity
IE970_RS26815	COG4565	transcriptional regulatory protein
IE970_RS26835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS26835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS26840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS26845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IE970_RS26855	COG0183	Belongs to the thiolase family
IE970_RS26860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IE970_RS26870	COG1414	Transcriptional regulator
IE970_RS26875	COG2840	Smr protein MutS2
IE970_RS26880	COG0583	DNA-binding transcription factor activity
IE970_RS26890	COG1473	amidohydrolase
IE970_RS26895	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IE970_RS26905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE970_RS26910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE970_RS27050	COG3567	Phage-associated protein, HI1409 family
IE970_RS27055	COG1783	phage Terminase large subunit
IE970_RS27080	COG3772	lysozyme
IE970_RS27195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE970_RS27200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IE970_RS27205	COG0589	response to stress
IE970_RS27215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IE970_RS27220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IE970_RS27235	COG0531	amino acid
IE970_RS27245	COG3136	membrane protein required for alginate biosynthesis
IE970_RS27255	COG0745	RESPONSE REGULATOR receiver
IE970_RS27265	COG0386	Belongs to the glutathione peroxidase family
IE970_RS27300	COG2205	protein histidine kinase activity
IE970_RS27310	COG0114	fumarate hydratase activity
IE970_RS27315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS27315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IE970_RS27320	COG1482	cell wall glycoprotein biosynthetic process
IE970_RS27325	COG5339	Protein conserved in bacteria
IE970_RS27330	COG1609	Transcriptional regulator
IE970_RS27340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE970_RS27385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IE970_RS27395	COG2391	methyltransferase activity
IE970_RS27400	COG0425	Belongs to the sulfur carrier protein TusA family
IE970_RS27415	COG0673	inositol 2-dehydrogenase activity
IE970_RS27425	COG2723	6-phospho-beta-galactosidase activity
IE970_RS27460	COG4659	FMN binding
IE970_RS27470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IE970_RS27480	COG0625	glutathione transferase activity
IE970_RS27500	COG3895	Periplasmic Protein
IE970_RS27515	COG3706	GGDEF domain
IE970_RS27530	COG1566	PFAM secretion protein HlyD family protein
IE970_RS27535	COG1289	transmembrane transporter activity
IE970_RS27545	COG4989	oxidoreductase activity
IE970_RS27550	COG3313	Fe-S protein
IE970_RS27555	COG1309	transcriptional regulator
IE970_RS27560	COG1902	pentaerythritol trinitrate reductase activity
IE970_RS27565	COG0346	lactoylglutathione lyase activity
IE970_RS27575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IE970_RS27580	COG0791	NLP P60 protein
IE970_RS27590	COG2814	Major facilitator Superfamily
IE970_RS27605	COG0583	DNA-binding transcription factor activity
IE970_RS27610	COG2814	Major facilitator Superfamily
IE970_RS27615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IE970_RS27620	COG0307	riboflavin synthase, alpha
IE970_RS27645	COG3729	General stress protein
IE970_RS27650	COG3685	Protein conserved in bacteria
IE970_RS27655	COG3685	Protein conserved in bacteria
IE970_RS27660	COG3546	catalase activity
IE970_RS27665	COG1271	oxidase subunit
IE970_RS27670	COG1294	oxidase, subunit
IE970_RS27685	COG1546	Belongs to the CinA family
IE970_RS27690	COG2323	membrane
IE970_RS27705	COG4529	Protein conserved in bacteria
IE970_RS27715	COG3111	PFAM Bacterial OB fold (BOF) protein
IE970_RS27720	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS27725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE970_RS27740	COG1349	DNA-binding transcription factor activity
IE970_RS27745	COG0346	lactoylglutathione lyase activity
IE970_RS27755	COG4166	transmembrane transport
IE970_RS27770	COG0444	Belongs to the ABC transporter superfamily
IE970_RS27780	COG4993	Dehydrogenase
IE970_RS27785	COG0582	viral genome integration into host DNA
IE970_RS27795	COG3121	Chaperone
IE970_RS27810	COG3539	Fimbrial protein
IE970_RS27815	COG0582	viral genome integration into host DNA
IE970_RS27845	COG1278	Cold shock
IE970_RS27870	COG3842	ATPase activity
IE970_RS27875	COG1175	transmembrane transport
IE970_RS27990	COG2885	chlorophyll binding
IE970_RS28015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IE970_RS28020	COG3383	formate dehydrogenase (NAD+) activity
IE970_RS28035	COG1126	abc transporter atp-binding protein
IE970_RS28040	COG0765	amino acid transport
IE970_RS28060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS28065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS28070	COG1120	ATPase activity
IE970_RS28075	COG4774	siderophore transport
IE970_RS28080	COG1116	anion transmembrane transporter activity
IE970_RS28085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE970_RS28100	COG1960	acyl-CoA dehydrogenase activity
IE970_RS28105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS28135	COG2814	Major facilitator Superfamily
IE970_RS28170	COG1414	Transcriptional regulator
IE970_RS28175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IE970_RS28180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE970_RS28185	COG1120	ATPase activity
IE970_RS28195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE970_RS28200	COG2271	Major facilitator Superfamily
IE970_RS28205	COG1082	Xylose isomerase domain protein TIM barrel
IE970_RS28205	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IE970_RS28230	COG1376	ErfK ybiS ycfS ynhG family protein
IE970_RS28245	COG0719	Fe-S assembly protein
IE970_RS28250	COG0396	ATPase activity
IE970_RS28255	COG0719	Fe-S assembly protein
IE970_RS28260	COG0316	Belongs to the HesB IscA family
IE970_RS28265	COG3539	Fimbrial protein
IE970_RS28280	COG3121	Chaperone
IE970_RS28295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IE970_RS28300	COG2261	transglycosylase associated protein
IE970_RS28305	COG2050	protein possibly involved in aromatic compounds catabolism
IE970_RS28310	COG0277	FAD linked oxidase domain protein
IE970_RS28310	COG0247	lactate metabolic process
IE970_RS28315	COG0628	permease
IE970_RS28325	COG0574	Belongs to the PEP-utilizing enzyme family
IE970_RS28325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IE970_RS28335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IE970_RS28340	COG4256	Hemin uptake protein
IE970_RS28350	COG0791	NLP P60 protein
IE970_RS28360	COG0386	Belongs to the glutathione peroxidase family
IE970_RS28380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE970_RS28380	COG0072	phenylalanine-tRNA ligase activity
IE970_RS28395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IE970_RS28420	COG3137	Salt-induced outer membrane protein
IE970_RS28425	COG1105	Belongs to the carbohydrate kinase PfkB family
IE970_RS28435	COG3001	Fructosamine kinase
IE970_RS28440	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IE970_RS28445	COG2350	Protein conserved in bacteria
IE970_RS28450	COG1902	pentaerythritol trinitrate reductase activity
IE970_RS28470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IE970_RS28480	COG0444	Belongs to the ABC transporter superfamily
IE970_RS28485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE970_RS28490	COG0601	transmembrane transport
IE970_RS28500	COG2095	MarC family integral membrane protein
IE970_RS28505	COG1454	alcohol dehydrogenase
IE970_RS28505	COG1012	belongs to the aldehyde dehydrogenase family
IE970_RS28520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IE970_RS28525	COG0745	RESPONSE REGULATOR receiver
IE970_RS28530	COG1752	Esterase of the alpha-beta hydrolase superfamily
IE970_RS28540	COG0788	formyltetrahydrofolate deformylase activity
IE970_RS28575	COG2181	nitrate reductase activity
IE970_RS28580	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IE970_RS28585	COG1140	nitrate reductase beta subunit
IE970_RS28590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IE970_RS28595	COG2223	nitrite transmembrane transporter activity
IE970_RS28600	COG3850	Histidine kinase
IE970_RS28605	COG2197	response regulator
IE970_RS28610	COG4932	domain protein
IE970_RS28615	COG0243	molybdopterin cofactor binding
IE970_RS28620	COG2146	nitrite reductase [NAD(P)H] activity
IE970_RS28620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IE970_RS28625	COG1116	anion transmembrane transporter activity
IE970_RS28635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE970_RS28640	COG3707	response regulator
IE970_RS28645	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IE970_RS28655	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IE970_RS28660	COG4572	Cation transport regulator
IE970_RS28665	COG0387	Pfam Sodium calcium exchanger
IE970_RS28685	COG2890	protein-(glutamine-N5) methyltransferase activity
IE970_RS28715	COG0659	secondary active sulfate transmembrane transporter activity
IE970_RS28735	COG0012	GTP binding
IE970_RS28740	COG0582	viral genome integration into host DNA
IE970_RS28755	COG3829	transcription factor binding
IE970_RS28760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IE970_RS28765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IE970_RS28770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE970_RS28780	COG0549	Belongs to the carbamate kinase family
IE970_RS28785	COG3608	succinylglutamate desuccinylase aspartoacylase
IE970_RS28785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IE970_RS28790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS28790	COG0493	'glutamate synthase
IE970_RS28795	COG0402	S-adenosylhomocysteine deaminase activity
IE970_RS28800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS28805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE970_RS28805	COG0493	'glutamate synthase
IE970_RS28810	COG2233	PERMEase
IE970_RS28820	COG2068	MobA-Related Protein
IE970_RS28835	COG2814	Major facilitator Superfamily
IE970_RS28840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS28840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS28845	COG2351	hydroxyisourate hydrolase activity
IE970_RS28865	COG0583	DNA-binding transcription factor activity
IE970_RS28870	COG0564	pseudouridine synthase activity
IE970_RS28885	COG1174	glycine betaine transport
IE970_RS28895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE970_RS28910	COG2814	Major facilitator Superfamily
IE970_RS28935	COG2308	Evidence 4 Homologs of previously reported genes of
IE970_RS28945	COG1472	Belongs to the glycosyl hydrolase 3 family
IE970_RS28955	COG2211	Major facilitator Superfamily
IE970_RS28970	COG1619	proteins homologs of microcin C7 resistance protein MccF
IE970_RS28990	COG2719	SpoVR family
IE970_RS29020	COG0179	Fumarylacetoacetate (FAA) hydrolase
IE970_RS29035	COG2894	cell division
IE970_RS29045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IE970_RS29055	COG3065	identical protein binding
IE970_RS29060	COG1214	PFAM Peptidase M22, glycoprotease
IE970_RS29065	COG1199	ATP-dependent helicase activity
IE970_RS29070	COG0251	oxidation-reduction process
IE970_RS29080	COG3842	ATPase activity
IE970_RS29085	COG0395	ABC-type sugar transport system, permease component
IE970_RS29090	COG1175	transmembrane transport
IE970_RS29095	COG1653	transport
IE970_RS29125	COG1760	l-serine dehydratase
IE970_RS29130	COG2200	EAL domain
IE970_RS29135	COG1253	flavin adenine dinucleotide binding
IE970_RS29140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE970_RS29140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE970_RS29145	COG3715	PTS system
IE970_RS29150	COG3716	PTS system mannose fructose sorbose family IID component
IE970_RS29165	COG2226	methyltransferase
IE970_RS29170	COG0768	penicillin binding
IE970_RS29200	COG1414	Transcriptional regulator
IE970_RS29205	COG2814	Major facilitator Superfamily
IE970_RS29230	COG1956	GAF domain-containing protein
IE970_RS29235	COG2995	paraquat-inducible protein a
IE970_RS29240	COG3008	intermembrane lipid transfer
IE970_RS29265	COG2990	Protein conserved in bacteria
IE970_RS29305	COG1276	copper resistance
IE970_RS29310	COG2372	response to copper ion
IE970_RS29320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IE970_RS29325	COG1770	oligopeptidase
IE970_RS29330	COG2979	Protein of unknown function (DUF533)
IE970_RS29335	COG3141	response to X-ray
IE970_RS29345	COG0800	Aldolase
IE970_RS29350	COG0129	dihydroxy-acid dehydratase activity
IE970_RS29355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IE970_RS29360	COG1737	Transcriptional regulator
IE970_RS29370	COG3493	citrate carrier protein
IE970_RS29375	COG0679	Auxin Efflux Carrier
IE970_RS29380	COG0281	malic enzyme
IE970_RS29390	COG1560	Kdo2-lipid A biosynthetic process
IE970_RS29395	COG0739	heme binding
IE970_RS29400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IE970_RS29410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE970_RS29430	COG0217	transcriptional regulatory protein
IE970_RS29435	COG0494	nUDIX hydrolase
IE970_RS29445	COG1335	isochorismatase
IE970_RS29450	COG1801	Protein of unknown function DUF72
IE970_RS29455	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IE970_RS29475	COG3102	Protein conserved in bacteria
IE970_RS29485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IE970_RS29515	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE970_RS29525	COG1879	ABC-type sugar transport system periplasmic component
IE970_RS29535	COG1528	Iron-storage protein
IE970_RS29555	COG0477	Major facilitator Superfamily
IE970_RS29565	COG1528	Iron-storage protein
IE970_RS29575	COG0814	amino acid
IE970_RS29580	COG3012	SEC-C Motif Domain Protein
IE970_RS29580	COG3318	Belongs to the UPF0149 family
IE970_RS29585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE970_RS29615	COG2197	response regulator
IE970_RS29625	COG2197	response regulator
IE970_RS29630	COG1126	abc transporter atp-binding protein
IE970_RS29635	COG0765	amino acid transport
IE970_RS29645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE970_RS29650	COG0366	Alpha amylase catalytic
IE970_RS29680	COG5475	Uncharacterized small protein (DUF2158)
IE970_RS29685	COG2354	Protein conserved in bacteria
IE970_RS29690	COG0697	spore germination
IE970_RS29695	COG3727	T/G mismatch-specific endonuclease activity
IE970_RS29700	COG0270	DNA (cytosine-5-)-methyltransferase activity
IE970_RS29705	COG1418	mRNA catabolic process
IE970_RS29715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE970_RS29725	COG0463	Glycosyl transferase, family 2
IE970_RS29795	COG0741	lytic transglycosylase activity
IE970_RS29810	COG4386	tail sheath protein
IE970_RS29895	COG3772	lysozyme
IE970_RS29910	COG1403	HNH endonuclease
IE970_RS29915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE970_RS30005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IE970_RS30040	COG0251	oxidation-reduction process
IE970_RS30060	COG2819	hydrolase of the alpha beta superfamily
IE970_RS30070	COG0589	response to stress
IE970_RS30080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE970_RS30110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IE970_RS30120	COG3311	Transcriptional regulator
IE970_RS30225	COG1695	Transcriptional regulator
IE970_RS30255	COG1357	PFAM Pentapeptide repeats (8 copies)
IE970_RS30275	COG3344	reverse transcriptase
IE970_RS30325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IE970_RS30340	COG1349	DNA-binding transcription factor activity
IE970_RS30345	COG2084	Dehydrogenase
IE970_RS30350	COG3395	kinase activity
IE970_RS30355	COG0235	Class ii aldolase
IE970_RS30390	COG4644	lycopene metabolic process
IE970_RS30445	COG1660	Displays ATPase and GTPase activities
IE970_RS30470	COG3173	Aminoglycoside phosphotransferase
IE970_RS30490	COG1695	Transcriptional regulator
IE970_RS30655	COG0633	Ferredoxin
IE970_RS30700	COG0629	single-stranded DNA binding
IE970_RS30710	COG0714	Associated with various cellular activities
IE970_RS30745	COG5001	Diguanylate cyclase
IE970_RS30770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IE970_RS30865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IE970_RS30945	COG1192	Involved in chromosome partitioning
IE970_RS31020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IE970_RS31130	COG0616	signal peptide processing
IE970_RS31270	COG4974	Belongs to the 'phage' integrase family
IE970_RS31325	COG0789	Transcriptional regulator
IE970_RS31355	COG0431	NADPH-dependent FMN reductase
IE970_RS31375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IE970_RS31380	COG1393	Belongs to the ArsC family
IE970_RS31385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IE970_RS31400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IE970_RS31435	COG0589	response to stress
IE970_RS31440	COG0659	secondary active sulfate transmembrane transporter activity
IE970_RS31445	COG0583	DNA-binding transcription factor activity
IE970_RS31450	COG0697	spore germination
IE970_RS31460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IE970_RS31715	COG5499	transcription regulator containing HTH domain
IE970_RS31970	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE970_RS32000	COG0739	heme binding
IE970_RS32010	COG2132	Multicopper oxidase
IE970_RS32015	COG3667	copper resistance
IE970_RS32020	COG2372	response to copper ion
IE970_RS32025	COG1276	copper resistance
IE970_RS32030	COG0745	RESPONSE REGULATOR receiver
IE970_RS32035	COG2205	protein histidine kinase activity
IE970_RS32125	COG2801	Transposase and inactivated derivatives
IE970_RS32135	COG2801	Transposase and inactivated derivatives
IE970_RS32220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE970_RS32275	COG3039	Transposase
IE970_RS32280	COG1528	Iron-storage protein
IE970_RS32295	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IE970_RS32310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE970_RS32320	COG0583	DNA-binding transcription factor activity
IE970_RS32335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE970_RS32340	COG0625	glutathione transferase activity
IE970_RS32350	COG1309	transcriptional regulator
IE970_RS32365	COG1136	(ABC) transporter
IE970_RS32380	COG1342	Belongs to the UPF0251 family
IE970_RS32395	COG0783	Belongs to the Dps family
IE970_RS32400	COG0640	Transcriptional regulator
IE970_RS32405	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE970_RS32455	COG1484	DNA-dependent DNA replication
IE970_RS32465	COG4644	lycopene metabolic process
IE970_RS32535	COG3328	transposase activity
IE970_RS32775	COG1475	DNA binding
IE970_RS32790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IE970_RS32805	COG0431	NADPH-dependent FMN reductase
IE970_RS32810	COG0640	Transcriptional regulator
IE970_RS32925	COG1196	nuclear chromosome segregation
IE970_RS32935	COG3328	transposase activity
IE970_RS32950	COG1484	DNA-dependent DNA replication
IE970_RS32955	COG4584	PFAM Integrase catalytic
IE970_RS32990	COG2801	Transposase and inactivated derivatives
IE970_RS33010	COG3436	PFAM IS66 Orf2 family protein
IE970_RS33105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE970_RS33140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE970_RS33150	COG1902	pentaerythritol trinitrate reductase activity
IE970_RS33155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IE970_RS33160	COG1028	Short-chain dehydrogenase reductase Sdr
IE970_RS33180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE970_RS33210	COG4644	lycopene metabolic process