locus-tag	class	description
KOX_RS00025	COG0542	response to heat
KOX_RS00040	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KOX_RS00045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KOX_RS00050	COG1605	Chorismate mutase
KOX_RS00050	COG0077	Prephenate dehydratase
KOX_RS00060	COG0287	Prephenate dehydrogenase
KOX_RS00060	COG1605	Chorismate mutase
KOX_RS00065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KOX_RS00075	COG2199	diguanylate cyclase activity
KOX_RS00080	COG2885	chlorophyll binding
KOX_RS00115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KOX_RS00120	COG4137	Cytochrome C assembly protein
KOX_RS00125	COG4536	flavin adenine dinucleotide binding
KOX_RS00140	COG0497	DNA recombination
KOX_RS00155	COG2867	negative regulation of translational initiation
KOX_RS00165	COG0582	viral genome integration into host DNA
KOX_RS00270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS00275	COG1126	abc transporter atp-binding protein
KOX_RS00280	COG0235	Class ii aldolase
KOX_RS00290	COG4235	cytochrome complex assembly
KOX_RS00290	COG3088	subunit of a heme lyase
KOX_RS00295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KOX_RS00300	COG1138	Cytochrome C-type biogenesis protein
KOX_RS00310	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KOX_RS00315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KOX_RS00320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KOX_RS00330	COG1858	cytochrome C peroxidase
KOX_RS00335	COG2814	Major facilitator Superfamily
KOX_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS00365	COG3188	usher protein
KOX_RS00390	COG3284	Transcriptional regulator
KOX_RS00395	COG0640	Transcriptional regulator
KOX_RS00400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KOX_RS00425	COG4575	ribosome binding
KOX_RS00435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOX_RS00440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KOX_RS00450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KOX_RS00455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KOX_RS00465	COG4176	ABC-type proline glycine betaine transport system permease component
KOX_RS00470	COG2113	Glycine betaine
KOX_RS00475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KOX_RS00485	COG1846	Transcriptional regulator
KOX_RS00490	COG1566	PFAM secretion protein HlyD family protein
KOX_RS00495	COG2814	Major facilitator Superfamily
KOX_RS00500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KOX_RS00520	COG1238	metal cluster binding
KOX_RS00525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOX_RS00530	COG2823	Periplasmic or secreted lipoprotein
KOX_RS00560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KOX_RS00580	COG1546	Belongs to the CinA family
KOX_RS00590	COG0803	Belongs to the bacterial solute-binding protein 9 family
KOX_RS00595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KOX_RS00605	COG2951	lytic endotransglycosylase activity
KOX_RS00610	COG3730	PTS system glucitol sorbitol-specific
KOX_RS00615	COG3732	PTS system glucitol sorbitol-specific
KOX_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS00630	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS00635	COG1349	DNA-binding transcription factor activity
KOX_RS00660	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
KOX_RS00665	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KOX_RS00670	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS00675	COG1609	Transcriptional regulator
KOX_RS00680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS00680	COG1263	PTS System
KOX_RS00685	COG2723	6-phospho-beta-galactosidase activity
KOX_RS00690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KOX_RS00700	COG3260	NADH ubiquinone oxidoreductase 20
KOX_RS00705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOX_RS00715	COG0650	Formate hydrogenlyase subunit 4
KOX_RS00720	COG0651	ATP synthesis coupled electron transport
KOX_RS00725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS00740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KOX_RS00745	COG0298	carbon dioxide binding
KOX_RS00750	COG0409	Hydrogenase expression formation protein
KOX_RS00755	COG0309	Hydrogenase expression formation protein (HypE)
KOX_RS00765	COG2755	lipolytic protein G-D-S-L family
KOX_RS00765	COG0657	acetylesterase activity
KOX_RS00770	COG2723	6-phospho-beta-galactosidase activity
KOX_RS00785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS00790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS00795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS00800	COG1447	Phosphotransferase system cellobiose-specific component IIA
KOX_RS00805	COG1940	carbohydrate kinase activity
KOX_RS00810	COG1609	Transcriptional regulator
KOX_RS00820	COG1121	(ABC) transporter
KOX_RS00825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KOX_RS00830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KOX_RS00850	COG3720	iron ion transport
KOX_RS00855	COG4558	Periplasmic binding protein
KOX_RS00860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS00865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KOX_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS00880	COG2271	Major facilitator Superfamily
KOX_RS00885	COG1063	alcohol dehydrogenase
KOX_RS00895	COG1454	alcohol dehydrogenase
KOX_RS00935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOX_RS00940	COG1538	Outer membrane efflux protein
KOX_RS00950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS00955	COG1132	(ABC) transporter
KOX_RS00985	COG3539	Fimbrial protein
KOX_RS00995	COG3121	Chaperone
KOX_RS01000	COG3188	usher protein
KOX_RS01010	COG3539	Fimbrial protein
KOX_RS01030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KOX_RS01050	COG0477	Major facilitator Superfamily
KOX_RS01060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KOX_RS01065	COG4942	peptidase
KOX_RS01065	COG1388	LysM domain
KOX_RS01125	COG2234	aminopeptidase activity
KOX_RS01150	COG0720	synthase
KOX_RS01155	COG0602	queuosine metabolic process
KOX_RS01175	COG3956	TIGRFAM MazG family protein
KOX_RS01180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KOX_RS01190	COG2205	protein histidine kinase activity
KOX_RS01190	COG3437	response regulator, receiver
KOX_RS01190	COG4999	Histidine kinase
KOX_RS01190	COG3850	Histidine kinase
KOX_RS01195	COG1929	Belongs to the glycerate kinase type-1 family
KOX_RS01200	COG4948	Mandelate Racemase Muconate Lactonizing
KOX_RS01205	COG4948	Mandelate Racemase Muconate Lactonizing
KOX_RS01210	COG2271	Major facilitator Superfamily
KOX_RS01215	COG0716	FMN binding
KOX_RS01220	COG0564	pseudouridine synthase activity
KOX_RS01225	COG3098	single-species biofilm formation
KOX_RS01245	COG1611	Belongs to the LOG family
KOX_RS01250	COG0814	amino acid
KOX_RS01255	COG1760	l-serine dehydratase
KOX_RS01260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KOX_RS01275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS01290	COG0235	Class ii aldolase
KOX_RS01295	COG0738	Major facilitator superfamily
KOX_RS01315	COG1349	DNA-binding transcription factor activity
KOX_RS01325	COG2363	Small membrane protein
KOX_RS01330	COG0583	DNA-binding transcription factor activity
KOX_RS01340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KOX_RS01345	COG2166	iron-sulfur cluster assembly
KOX_RS01350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KOX_RS01355	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KOX_RS01520	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KOX_RS01535	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
KOX_RS01550	COG1454	alcohol dehydrogenase
KOX_RS01550	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS01555	COG4656	Part of a membrane complex involved in electron transport
KOX_RS01585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KOX_RS01590	COG0860	N-Acetylmuramoyl-L-alanine amidase
KOX_RS01595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KOX_RS01595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KOX_RS01600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KOX_RS01605	COG1074	ATP-dependent DNA helicase activity
KOX_RS01610	COG1025	Belongs to the peptidase M16 family
KOX_RS01615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KOX_RS01620	COG4967	type IV pilus modification protein PilV
KOX_RS01630	COG4795	General secretion pathway protein
KOX_RS01635	COG2165	general secretion pathway protein
KOX_RS01670	COG0861	Integral membrane protein TerC family
KOX_RS01680	COG0667	Aldo Keto reductase
KOX_RS01695	COG1609	Transcriptional regulator
KOX_RS01705	COG2186	Transcriptional regulator
KOX_RS01710	COG2723	6-phospho-beta-galactosidase activity
KOX_RS01715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS01720	COG1609	Transcriptional regulator
KOX_RS01730	COG0583	DNA-binding transcription factor activity
KOX_RS01735	COG3121	Chaperone
KOX_RS01740	COG3188	usher protein
KOX_RS01760	COG1794	racemase activity, acting on amino acids and derivatives
KOX_RS01770	COG1175	transmembrane transport
KOX_RS01775	COG0395	ABC-type sugar transport system, permease component
KOX_RS01780	COG3842	ATPase activity
KOX_RS01790	COG0823	Involved in the tonB-independent uptake of proteins
KOX_RS01815	COG2814	Major facilitator Superfamily
KOX_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS01825	COG0823	Involved in the tonB-independent uptake of proteins
KOX_RS01835	COG0183	Belongs to the thiolase family
KOX_RS01850	COG0814	amino acid
KOX_RS01855	COG0667	Aldo Keto reductase
KOX_RS01900	COG0640	Transcriptional regulator
KOX_RS01915	COG0697	spore germination
KOX_RS01920	COG1846	Transcriptional regulator
KOX_RS01925	COG1522	sequence-specific DNA binding
KOX_RS01935	COG2388	GCN5-related N-acetyl-transferase
KOX_RS01940	COG3592	Divergent 4Fe-4S mono-cluster
KOX_RS01955	COG1289	transmembrane transporter activity
KOX_RS01960	COG1538	Outer membrane efflux protein
KOX_RS01965	COG2909	trisaccharide binding
KOX_RS02005	COG1349	DNA-binding transcription factor activity
KOX_RS02010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KOX_RS02015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS02065	COG1929	Belongs to the glycerate kinase type-1 family
KOX_RS02070	COG3835	regulator
KOX_RS02075	COG2223	nitrite transmembrane transporter activity
KOX_RS02085	COG0583	DNA-binding transcription factor activity
KOX_RS02130	COG0667	Aldo Keto reductase
KOX_RS02150	COG2003	Belongs to the UPF0758 family
KOX_RS02170	COG2378	regulation of single-species biofilm formation
KOX_RS02180	COG2378	regulation of single-species biofilm formation
KOX_RS02185	COG3596	GTP binding
KOX_RS02210	COG2814	Major facilitator Superfamily
KOX_RS02220	COG0667	Aldo Keto reductase
KOX_RS02230	COG5002	protein histidine kinase activity
KOX_RS02255	COG1560	Kdo2-lipid A biosynthetic process
KOX_RS02270	COG3459	Glycosyltransferase 36 associated
KOX_RS02275	COG1278	Cold shock
KOX_RS02290	COG0656	L-ascorbic acid biosynthetic process
KOX_RS02295	COG0667	Aldo Keto reductase
KOX_RS02305	COG0702	epimerase
KOX_RS02325	COG0582	viral genome integration into host DNA
KOX_RS02335	COG4942	peptidase
KOX_RS02340	COG0583	DNA-binding transcription factor activity
KOX_RS02345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KOX_RS02355	COG1811	Na channel or pump
KOX_RS02375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KOX_RS02390	COG0716	FMN binding
KOX_RS02400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KOX_RS02420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS02420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS02425	COG3715	PTS system
KOX_RS02430	COG3716	PTS system mannose fructose sorbose family IID component
KOX_RS02445	COG1272	protein, Hemolysin III
KOX_RS02455	COG1737	Transcriptional regulator
KOX_RS02460	COG2723	6-phospho-beta-galactosidase activity
KOX_RS02465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KOX_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS02490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOX_RS02495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOX_RS02500	COG0006	proline dipeptidase activity
KOX_RS02515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KOX_RS02520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KOX_RS02535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KOX_RS02535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KOX_RS02540	COG1703	isobutyryl-CoA mutase activity
KOX_RS02545	COG1024	Enoyl-CoA hydratase
KOX_RS02550	COG0427	acetyl-CoA hydrolase
KOX_RS02555	COG0583	DNA-binding transcription factor activity
KOX_RS02560	COG2968	Membrane
KOX_RS02570	COG0668	transmembrane transport
KOX_RS02575	COG0191	fructose-bisphosphate aldolase activity
KOX_RS02610	COG1122	ATPase activity
KOX_RS02615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KOX_RS02620	COG0501	Belongs to the peptidase M48B family
KOX_RS02640	COG2814	Major facilitator Superfamily
KOX_RS02650	COG2356	endonuclease I
KOX_RS02655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KOX_RS02660	COG0189	ligase activity
KOX_RS02675	COG2197	response regulator
KOX_RS02680	COG2805	Type II/IV secretion system protein
KOX_RS02685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KOX_RS02690	COG0762	integral membrane protein
KOX_RS02705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KOX_RS02710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KOX_RS02715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KOX_RS02730	COG3171	Protein conserved in bacteria
KOX_RS02740	COG1194	a g-specific adenine glycosylase
KOX_RS02755	COG2211	Major facilitator Superfamily
KOX_RS02760	COG1982	Orn Lys Arg decarboxylase major
KOX_RS02765	COG1811	Na channel or pump
KOX_RS02775	COG0471	metal ion transport
KOX_RS02785	COG0626	cystathionine gamma-synthase activity
KOX_RS02805	COG2365	Tyrosine phosphatase family
KOX_RS02815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOX_RS02820	COG0754	glutathionylspermidine amidase activity
KOX_RS02830	COG0625	glutathione transferase activity
KOX_RS02850	COG0848	biopolymer transport protein
KOX_RS02865	COG0586	Pfam SNARE associated Golgi protein
KOX_RS02870	COG2207	Transcriptional regulator
KOX_RS02875	COG1979	alcohol dehydrogenase
KOX_RS02890	COG1032	radical SAM domain protein
KOX_RS02895	COG2132	Multicopper oxidase
KOX_RS02900	COG0204	Acyl-transferase
KOX_RS02910	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KOX_RS02915	COG3111	PFAM Bacterial OB fold (BOF) protein
KOX_RS02920	COG0745	RESPONSE REGULATOR receiver
KOX_RS02925	COG0642	Histidine kinase
KOX_RS02930	COG2249	NAD(P)H dehydrogenase (quinone) activity
KOX_RS02935	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KOX_RS02945	COG3150	esterase
KOX_RS02950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KOX_RS02955	COG3151	Protein conserved in bacteria
KOX_RS02960	COG0494	nUDIX hydrolase
KOX_RS02975	COG0754	glutathionylspermidine amidase activity
KOX_RS02980	COG3384	dioxygenase
KOX_RS02990	COG3539	Fimbrial protein
KOX_RS02995	COG3188	usher protein
KOX_RS03000	COG3121	Chaperone
KOX_RS03005	COG3539	Fimbrial protein
KOX_RS03015	COG2960	long-chain fatty acid transporting porin activity
KOX_RS03035	COG3025	triphosphatase activity
KOX_RS03040	COG4991	sh3 domain protein
KOX_RS03055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KOX_RS03110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KOX_RS03115	COG0358	DNA primase activity
KOX_RS03160	COG2376	Dihydroxyacetone kinase
KOX_RS03165	COG1461	Dihydroxyacetone kinase
KOX_RS03180	COG2375	cellular response to nickel ion
KOX_RS03185	COG1695	Transcriptional regulator
KOX_RS03195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KOX_RS03200	COG1609	Transcriptional regulator
KOX_RS03205	COG3250	beta-galactosidase activity
KOX_RS03210	COG2731	YhcH YjgK YiaL family protein
KOX_RS03215	COG0531	amino acid
KOX_RS03220	COG0531	amino acid
KOX_RS03230	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KOX_RS03230	COG3408	Glycogen debranching enzyme
KOX_RS03285	COG0446	pyridine nucleotide-disulphide oxidoreductase
KOX_RS03285	COG1902	pentaerythritol trinitrate reductase activity
KOX_RS03295	COG2211	Major facilitator Superfamily
KOX_RS03305	COG3507	Belongs to the glycosyl hydrolase 43 family
KOX_RS03310	COG1451	nucleotide metabolic process
KOX_RS03315	COG0673	inositol 2-dehydrogenase activity
KOX_RS03335	COG2721	sulfolactate sulfo-lyase activity
KOX_RS03345	COG2271	Major facilitator Superfamily
KOX_RS03350	COG2186	Transcriptional regulator
KOX_RS03355	COG0586	Pfam SNARE associated Golgi protein
KOX_RS03365	COG1422	Protein of unknown function (DUF1090)
KOX_RS03370	COG4575	ribosome binding
KOX_RS03375	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
KOX_RS03385	COG2259	Doxx family
KOX_RS03390	COG0435	Glutathione S-transferase
KOX_RS03395	COG3152	Membrane
KOX_RS03400	COG0583	DNA-binding transcription factor activity
KOX_RS03405	COG1741	Belongs to the pirin family
KOX_RS03415	COG1929	Belongs to the glycerate kinase type-1 family
KOX_RS03420	COG2084	Dehydrogenase
KOX_RS03430	COG2271	Major facilitator Superfamily
KOX_RS03435	COG2721	sulfolactate sulfo-lyase activity
KOX_RS03440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS03445	COG1349	DNA-binding transcription factor activity
KOX_RS03460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS03460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS03460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS03465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS03465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS03470	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
KOX_RS03475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS03480	COG3414	Phosphotransferase system galactitol-specific IIB component
KOX_RS03485	COG3775	system Galactitol-specific IIC component
KOX_RS03490	COG1063	alcohol dehydrogenase
KOX_RS03505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KOX_RS03525	COG2823	Periplasmic or secreted lipoprotein
KOX_RS03530	COG0701	Predicted permease
KOX_RS03535	COG0702	epimerase
KOX_RS03540	COG0693	protein deglycase activity
KOX_RS03550	COG2827	Endonuclease containing a URI domain
KOX_RS03555	COG3153	acetyltransferase
KOX_RS03560	COG3154	lipid carrier protein
KOX_RS03565	COG0826	peptidase U32
KOX_RS03570	COG0826	peptidase U32
KOX_RS03575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS03580	COG0814	amino acid
KOX_RS03585	COG0513	Belongs to the DEAD box helicase family
KOX_RS03615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KOX_RS03620	COG0195	Participates in both transcription termination and antitermination
KOX_RS03645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KOX_RS03655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KOX_RS03660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KOX_RS03670	COG1534	Rna-binding protein
KOX_RS03680	COG2027	D-alanyl-D-alanine carboxypeptidase
KOX_RS03690	COG0697	spore germination
KOX_RS03705	COG0142	geranyltranstransferase activity
KOX_RS03710	COG3423	Transcriptional regulator
KOX_RS03720	COG5007	Belongs to the BolA IbaG family
KOX_RS03725	COG3113	response to antibiotic
KOX_RS03730	COG2854	intermembrane phospholipid transfer
KOX_RS03735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KOX_RS03740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOX_RS03745	COG1127	ABC transporter
KOX_RS03750	COG0530	calcium, potassium:sodium antiporter activity
KOX_RS03760	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KOX_RS03765	COG3117	lipopolysaccharide transmembrane transporter activity
KOX_RS03770	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KOX_RS03775	COG1137	ATPase activity
KOX_RS03780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KOX_RS03785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KOX_RS03790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS03795	COG1660	Displays ATPase and GTPase activities
KOX_RS03800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS03805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KOX_RS03810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KOX_RS03815	COG5002	protein histidine kinase activity
KOX_RS03815	COG2198	Histidine kinase
KOX_RS03815	COG0784	Response regulator, receiver
KOX_RS03820	COG1242	4 iron, 4 sulfur cluster binding
KOX_RS03825	COG0067	glutamate synthase
KOX_RS03825	COG0069	glutamate synthase activity
KOX_RS03825	COG0070	glutamate synthase
KOX_RS03830	COG0493	'glutamate synthase
KOX_RS03835	COG2731	YhcH YjgK YiaL family protein
KOX_RS03865	COG2969	positive regulation of protein catabolic process
KOX_RS03870	COG0625	glutathione transferase activity
KOX_RS03885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KOX_RS03890	COG3105	Protein conserved in bacteria
KOX_RS03895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KOX_RS03900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KOX_RS03925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS03930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS03935	COG0471	metal ion transport
KOX_RS03945	COG1802	Transcriptional regulator
KOX_RS03970	COG2732	(Barnase) inhibitor
KOX_RS03975	COG1289	transmembrane transporter activity
KOX_RS03990	COG0583	DNA-binding transcription factor activity
KOX_RS03995	COG1349	DNA-binding transcription factor activity
KOX_RS04000	COG0312	modulator of DNA gyrase
KOX_RS04005	COG3164	Protein of unknown function
KOX_RS04020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KOX_RS04025	COG1792	Involved in formation and maintenance of cell shape
KOX_RS04030	COG1077	Cell shape determining protein MreB Mrl
KOX_RS04035	COG2199	diguanylate cyclase activity
KOX_RS04035	COG2200	EAL domain
KOX_RS04040	COG0604	alcohol dehydrogenase
KOX_RS04060	COG0511	ligase activity, forming carbon-carbon bonds
KOX_RS04065	COG0439	Biotin carboxylase
KOX_RS04070	COG3924	membrane
KOX_RS04075	COG4145	pantothenate transmembrane transporter activity
KOX_RS04100	COG1309	transcriptional regulator
KOX_RS04105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS04110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOX_RS04150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KOX_RS04175	COG0758	DNA mediated transformation
KOX_RS04205	COG3036	rescue of stalled ribosome
KOX_RS04210	COG0789	Transcriptional regulator
KOX_RS04220	COG0203	ribosomal protein L17
KOX_RS04225	COG0202	RNA polymerase activity
KOX_RS04235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KOX_RS04250	COG0201	protein transport
KOX_RS04265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KOX_RS04315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KOX_RS04330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KOX_RS04345	COG0088	Forms part of the polypeptide exit tunnel
KOX_RS04355	COG0051	transcription antitermination factor activity, RNA binding
KOX_RS04410	COG2964	Protein conserved in bacteria
KOX_RS04415	COG0545	Peptidyl-prolyl cis-trans isomerase
KOX_RS04425	COG1047	Peptidyl-prolyl cis-trans
KOX_RS04430	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KOX_RS04445	COG0488	(ABC) transporter
KOX_RS04455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KOX_RS04465	COG0429	hydrolase of the alpha beta-hydrolase fold
KOX_RS04475	COG3954	Phosphoribulokinase
KOX_RS04480	COG1765	OsmC-like protein
KOX_RS04490	COG1289	transmembrane transporter activity
KOX_RS04495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KOX_RS04515	COG0738	Major facilitator superfamily
KOX_RS04520	COG0402	S-adenosylhomocysteine deaminase activity
KOX_RS04525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KOX_RS04530	COG2146	nitrite reductase [NAD(P)H] activity
KOX_RS04555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KOX_RS04560	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KOX_RS04565	COG3266	domain, Protein
KOX_RS04580	COG4796	Type ii and iii secretion system protein
KOX_RS04600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KOX_RS04605	COG0494	nUDIX hydrolase
KOX_RS04615	COG1011	Hydrolase
KOX_RS04620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KOX_RS04635	COG1640	4-alpha-glucanotransferase
KOX_RS04640	COG0058	SHG alpha-glucan phosphorylase activity
KOX_RS04655	COG1349	DNA-binding transcription factor activity
KOX_RS04670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KOX_RS04675	COG0058	SHG alpha-glucan phosphorylase activity
KOX_RS04700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KOX_RS04705	COG2610	gluconate transmembrane transporter activity
KOX_RS04710	COG3265	gluconokinase activity
KOX_RS04715	COG1609	Transcriptional regulator
KOX_RS04720	COG1741	Belongs to the pirin family
KOX_RS04725	COG0673	inositol 2-dehydrogenase activity
KOX_RS04735	COG1247	-acetyltransferase
KOX_RS04740	COG0405	Gamma-glutamyltransferase
KOX_RS04750	COG0584	glycerophosphoryl diester phosphodiesterase
KOX_RS04775	COG1414	Transcriptional regulator
KOX_RS04780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KOX_RS04785	COG2271	Major facilitator Superfamily
KOX_RS04790	COG2721	sulfolactate sulfo-lyase activity
KOX_RS04815	COG0683	leucine binding
KOX_RS04825	COG0683	leucine binding
KOX_RS04835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KOX_RS04850	COG2177	Part of the ABC transporter FtsEX involved in
KOX_RS04855	COG2884	Cell division ATP-binding protein ftsE
KOX_RS04860	COG0552	protein localization to endoplasmic reticulum
KOX_RS04865	COG0742	ribosomal rna small subunit methyltransferase
KOX_RS04870	COG3776	membrane
KOX_RS04880	COG3714	YhhN family
KOX_RS04895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KOX_RS04905	COG0477	Major facilitator Superfamily
KOX_RS04910	COG0628	permease
KOX_RS04940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KOX_RS04960	COG1216	Glycosyl transferase, family 2
KOX_RS04985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOX_RS04995	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS05000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOX_RS05005	COG2091	lysine biosynthetic process via aminoadipic acid
KOX_RS05045	COG3479	Phenolic acid decarboxylase
KOX_RS05060	COG0747	negative chemotaxis
KOX_RS05065	COG0601	transmembrane transport
KOX_RS05070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS05075	COG0444	Belongs to the ABC transporter superfamily
KOX_RS05095	COG2239	Acts as a magnesium transporter
KOX_RS05100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KOX_RS05105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KOX_RS05110	COG0471	metal ion transport
KOX_RS05115	COG3964	amidohydrolase
KOX_RS05120	COG2204	response regulator
KOX_RS05125	COG2081	HI0933 family
KOX_RS05130	COG0306	phosphate transporter
KOX_RS05140	COG0589	response to stress
KOX_RS05160	COG2610	gluconate transmembrane transporter activity
KOX_RS05195	COG1918	ferrous iron import across plasma membrane
KOX_RS05200	COG2183	response to ionizing radiation
KOX_RS05205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KOX_RS05220	COG0671	phosphoesterase, PA-phosphatase related
KOX_RS05225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KOX_RS05230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KOX_RS05235	COG0625	glutathione transferase activity
KOX_RS05240	COG1454	alcohol dehydrogenase
KOX_RS05260	COG2197	response regulator
KOX_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS05270	COG0583	DNA-binding transcription factor activity
KOX_RS05275	COG1295	ribonuclease BN
KOX_RS05280	COG0477	Major facilitator Superfamily
KOX_RS05295	COG0612	Peptidase, M16
KOX_RS05305	COG2200	EAL domain
KOX_RS05305	COG2199	diguanylate cyclase activity
KOX_RS05310	COG3118	belongs to the thioredoxin family
KOX_RS05310	COG0457	Tetratricopeptide repeat
KOX_RS05315	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KOX_RS05320	COG1215	transferase activity, transferring glycosyl groups
KOX_RS05355	COG2194	sulfuric ester hydrolase activity
KOX_RS05380	COG0457	Tetratricopeptide repeat
KOX_RS05395	COG0489	protein tyrosine kinase activity
KOX_RS05405	COG4608	Belongs to the ABC transporter superfamily
KOX_RS05410	COG0444	Belongs to the ABC transporter superfamily
KOX_RS05415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS05420	COG0601	transmembrane transport
KOX_RS05425	COG0747	negative chemotaxis
KOX_RS05440	COG2223	nitrite transmembrane transporter activity
KOX_RS05445	COG5571	outer membrane autotransporter
KOX_RS05450	COG2818	Glycosylase
KOX_RS05455	COG0456	acetyltransferase
KOX_RS05460	COG0243	molybdopterin cofactor binding
KOX_RS05465	COG2885	chlorophyll binding
KOX_RS05470	COG1609	Transcriptional regulator
KOX_RS05480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS05500	COG2814	Major facilitator Superfamily
KOX_RS05505	COG2944	sequence-specific DNA binding
KOX_RS05510	COG1278	Cold shock
KOX_RS05540	COG3274	enterobacterial common antigen metabolic process
KOX_RS05545	COG4682	membrane
KOX_RS05550	COG1070	Carbohydrate kinase
KOX_RS05555	COG2115	Belongs to the xylose isomerase family
KOX_RS05560	COG4213	ABC transporter substrate-binding protein
KOX_RS05570	COG4214	carbohydrate transport
KOX_RS05575	COG2207	Transcriptional regulator
KOX_RS05575	COG1609	Transcriptional regulator
KOX_RS05580	COG2992	FlgJ-related protein
KOX_RS05585	COG0366	Alpha amylase catalytic
KOX_RS05590	COG3977	Valine--pyruvate aminotransferase
KOX_RS05595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS05600	COG1414	Transcriptional regulator
KOX_RS05610	COG2731	YhcH YjgK YiaL family protein
KOX_RS05625	COG1070	Carbohydrate kinase
KOX_RS05630	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KOX_RS05635	COG3623	hexulose-6-phosphate isomerase
KOX_RS05640	COG0235	Class ii aldolase
KOX_RS05645	COG4977	sequence-specific DNA binding
KOX_RS05645	COG1917	Cupin 2, conserved barrel domain protein
KOX_RS05660	COG3276	selenocysteine insertion sequence binding
KOX_RS05670	COG0625	glutathione transferase activity
KOX_RS05675	COG1566	PFAM secretion protein HlyD family protein
KOX_RS05695	COG3722	fumarate hydratase activity
KOX_RS05715	COG2186	Transcriptional regulator
KOX_RS05725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KOX_RS05745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KOX_RS05750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KOX_RS05760	COG4942	peptidase
KOX_RS05765	COG2861	carbohydrate metabolic process
KOX_RS05770	COG0463	Glycosyl transferase, family 2
KOX_RS05780	COG0156	8-amino-7-oxononanoate synthase activity
KOX_RS05790	COG0859	PFAM glycosyl transferase family 9
KOX_RS05795	COG0859	PFAM glycosyl transferase family 9
KOX_RS05820	COG0859	PFAM glycosyl transferase family 9
KOX_RS05830	COG0438	transferase activity, transferring glycosyl groups
KOX_RS05835	COG1216	Glycosyl transferase, family 2
KOX_RS05840	COG1519	Transferase
KOX_RS05860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KOX_RS05865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KOX_RS05875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KOX_RS05890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KOX_RS05900	COG1561	YicC-like family, N-terminal region
KOX_RS05910	COG2860	membrane
KOX_RS05930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KOX_RS05935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOX_RS05940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KOX_RS05945	COG1494	fructose-1,6-bisphosphatase
KOX_RS05955	COG3152	Membrane
KOX_RS05985	COG3074	FtsZ-dependent cytokinesis
KOX_RS06000	COG0786	glutamate:sodium symporter activity
KOX_RS06005	COG2233	PERMEase
KOX_RS06010	COG2982	Protein involved in outer membrane biogenesis
KOX_RS06015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS06015	COG1263	PTS System
KOX_RS06020	COG1486	melibiose metabolic process
KOX_RS06035	COG1940	carbohydrate kinase activity
KOX_RS06040	COG0191	fructose-bisphosphate aldolase activity
KOX_RS06050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS06050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS06055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS06060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS06060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS06060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS06065	COG3711	transcriptional antiterminator
KOX_RS06070	COG1501	Belongs to the glycosyl hydrolase 31 family
KOX_RS06075	COG2211	Major facilitator Superfamily
KOX_RS06105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KOX_RS06125	COG1064	alcohol dehydrogenase
KOX_RS06135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KOX_RS06150	COG1464	Belongs to the NlpA lipoprotein family
KOX_RS06165	COG0583	DNA-binding transcription factor activity
KOX_RS06175	COG1309	transcriptional regulator
KOX_RS06185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS06190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOX_RS06200	COG2814	Major facilitator Superfamily
KOX_RS06210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS06210	COG1263	PTS System
KOX_RS06225	COG0697	spore germination
KOX_RS06235	COG5464	transposase or invertase
KOX_RS06245	COG1609	Transcriptional regulator
KOX_RS06255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS06255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS06260	COG1447	Phosphotransferase system cellobiose-specific component IIA
KOX_RS06290	COG2188	Transcriptional regulator
KOX_RS06340	COG2197	response regulator
KOX_RS06345	COG0440	acetolactate synthase activity
KOX_RS06350	COG0028	Belongs to the TPP enzyme family
KOX_RS06365	COG2814	Major facilitator Superfamily
KOX_RS06370	COG0583	DNA-binding transcription factor activity
KOX_RS06375	COG2610	gluconate transmembrane transporter activity
KOX_RS06385	COG0641	radical SAM
KOX_RS06395	COG2149	membrane
KOX_RS06410	COG2188	Transcriptional regulator
KOX_RS06430	COG5645	(Lipo)protein
KOX_RS06435	COG0823	Involved in the tonB-independent uptake of proteins
KOX_RS06440	COG2271	Major facilitator Superfamily
KOX_RS06450	COG0800	Aldolase
KOX_RS06455	COG3734	2-keto-3-deoxy-galactonokinase
KOX_RS06460	COG2186	Transcriptional regulator
KOX_RS06465	COG0561	phosphatase activity
KOX_RS06475	COG0583	DNA-binding transcription factor activity
KOX_RS06480	COG0187	DNA topoisomerase II activity
KOX_RS06490	COG0592	DNA-directed DNA polymerase activity
KOX_RS06515	COG0456	acetyltransferase
KOX_RS06530	COG2091	lysine biosynthetic process via aminoadipic acid
KOX_RS06535	COG0431	NADPH-dependent FMN reductase
KOX_RS06540	COG2252	PERMEase
KOX_RS06545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOX_RS06550	COG0363	glucosamine-6-phosphate deaminase activity
KOX_RS06555	COG2382	esterase
KOX_RS06565	COG0704	Plays a role in the regulation of phosphate uptake
KOX_RS06570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KOX_RS06575	COG0581	inorganic phosphate transmembrane transporter activity
KOX_RS06580	COG0573	inorganic phosphate transmembrane transporter activity
KOX_RS06585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KOX_RS06590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KOX_RS06645	COG3312	ion transport
KOX_RS06660	COG0716	FMN binding
KOX_RS06665	COG1522	sequence-specific DNA binding
KOX_RS06695	COG1129	ABC transporter
KOX_RS06700	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS06710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS06715	COG1609	Transcriptional regulator
KOX_RS06720	COG0477	Major facilitator Superfamily
KOX_RS06725	COG2186	Transcriptional regulator
KOX_RS06745	COG1763	Mo-molybdopterin cofactor biosynthetic process
KOX_RS06755	COG3084	Protein conserved in bacteria
KOX_RS06760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KOX_RS06770	COG0204	Acyl-transferase
KOX_RS06790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KOX_RS06800	COG3852	Histidine kinase
KOX_RS06815	COG1011	Hydrolase
KOX_RS06825	COG1490	D-aminoacyl-tRNA deacylase activity
KOX_RS06830	COG0456	acetyltransferase
KOX_RS06835	COG0657	acetylesterase activity
KOX_RS06845	COG2864	formate dehydrogenase
KOX_RS06850	COG0437	4 iron, 4 sulfur cluster binding
KOX_RS06855	COG0243	molybdopterin cofactor binding
KOX_RS06855	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS06860	COG0243	molybdopterin cofactor binding
KOX_RS06860	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS06875	COG0205	6-phosphofructokinase activity
KOX_RS06915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KOX_RS06960	COG2211	Major facilitator Superfamily
KOX_RS06965	COG0110	maltose O-acetyltransferase activity
KOX_RS06980	COG3539	Fimbrial protein
KOX_RS06990	COG3121	Chaperone
KOX_RS06995	COG3188	usher protein
KOX_RS07010	COG3539	Fimbrial protein
KOX_RS07020	COG3121	Chaperone
KOX_RS07035	COG0668	transmembrane transport
KOX_RS07050	COG1609	Transcriptional regulator
KOX_RS07055	COG2211	Major facilitator Superfamily
KOX_RS07060	COG1621	beta-fructofuranosidase activity
KOX_RS07080	COG1454	alcohol dehydrogenase
KOX_RS07090	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS07095	COG1129	ABC transporter
KOX_RS07140	COG2258	MOSC domain
KOX_RS07145	COG2205	protein histidine kinase activity
KOX_RS07150	COG0745	RESPONSE REGULATOR receiver
KOX_RS07155	COG3678	ATP-independent chaperone mediated protein folding
KOX_RS07175	COG1575	Belongs to the MenA family. Type 1 subfamily
KOX_RS07190	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KOX_RS07195	COG1609	Transcriptional regulator
KOX_RS07200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KOX_RS07215	COG0626	cystathionine gamma-synthase activity
KOX_RS07220	COG0460	homoserine dehydrogenase
KOX_RS07220	COG0527	aspartate kinase activity
KOX_RS07225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOX_RS07230	COG0583	DNA-binding transcription factor activity
KOX_RS07240	COG1349	DNA-binding transcription factor activity
KOX_RS07245	COG0371	Dehydrogenase
KOX_RS07255	COG2207	Transcriptional regulator
KOX_RS07260	COG3443	Belongs to the bacterial solute-binding protein 9 family
KOX_RS07275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KOX_RS07295	COG0583	DNA-binding transcription factor activity
KOX_RS07370	COG3085	chromosome segregation
KOX_RS07385	COG3978	acetolactate synthase activity
KOX_RS07390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KOX_RS07400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KOX_RS07405	COG0583	DNA-binding transcription factor activity
KOX_RS07415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KOX_RS07420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KOX_RS07455	COG1397	ADP-ribosylglycohydrolase
KOX_RS07475	COG3118	belongs to the thioredoxin family
KOX_RS07480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KOX_RS07485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KOX_RS07495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KOX_RS07500	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KOX_RS07505	COG0456	acetyltransferase
KOX_RS07510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOX_RS07515	COG2244	polysaccharide biosynthetic process
KOX_RS07560	COG3071	HemY protein
KOX_RS07565	COG2959	enzyme of heme biosynthesis
KOX_RS07570	COG1587	Uroporphyrinogen-III synthase
KOX_RS07580	COG3072	Adenylate cyclase
KOX_RS07595	COG0477	Major facilitator Superfamily
KOX_RS07600	COG1228	amidohydrolase
KOX_RS07610	COG5567	small periplasmic lipoprotein
KOX_RS07630	COG1011	Hydrolase
KOX_RS07635	COG0210	DNA helicase
KOX_RS07640	COG0598	Magnesium transport protein CorA
KOX_RS07650	COG2050	protein possibly involved in aromatic compounds catabolism
KOX_RS07665	COG1280	lysine exporter protein (LysE YggA)
KOX_RS07675	COG1280	lysine exporter protein (LysE YggA)
KOX_RS07680	COG2267	carboxylic ester hydrolase activity
KOX_RS07685	COG0561	phosphatase activity
KOX_RS07690	COG0697	spore germination
KOX_RS07695	COG0583	DNA-binding transcription factor activity
KOX_RS07710	COG0412	Dienelactone hydrolase
KOX_RS07730	COG3165	ubiquinone biosynthetic process from chorismate
KOX_RS07740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KOX_RS07750	COG0805	protein transport
KOX_RS07795	COG1739	Uncharacterized protein family UPF0029
KOX_RS07805	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KOX_RS07835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KOX_RS07875	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KOX_RS07880	COG0250	Participates in transcription elongation, termination and antitermination
KOX_RS07915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KOX_RS07920	COG1447	Phosphotransferase system cellobiose-specific component IIA
KOX_RS07930	COG3706	GGDEF domain
KOX_RS07935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KOX_RS07945	COG2104	thiamine diphosphate biosynthetic process
KOX_RS07950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KOX_RS07965	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
KOX_RS08005	COG4191	Histidine kinase
KOX_RS08015	COG0151	Belongs to the GarS family
KOX_RS08055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KOX_RS08105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KOX_RS08145	COG1187	pseudouridine synthase activity
KOX_RS08160	COG4650	regulator
KOX_RS08170	COG3541	Predicted nucleotidyltransferase
KOX_RS08175	COG0527	aspartate kinase activity
KOX_RS08190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KOX_RS08200	COG0251	oxidation-reduction process
KOX_RS08270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KOX_RS08280	COG0534	Mate efflux family protein
KOX_RS08285	COG3237	CsbD-like
KOX_RS08290	COG0735	belongs to the Fur family
KOX_RS08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KOX_RS08315	COG0305	Participates in initiation and elongation during chromosome replication
KOX_RS08320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KOX_RS08325	COG1448	Aminotransferase
KOX_RS08335	COG0432	Pfam Uncharacterised protein family UPF0047
KOX_RS08340	COG2315	Protein conserved in bacteria
KOX_RS08355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KOX_RS08360	COG0629	single-stranded DNA binding
KOX_RS08365	COG0741	lytic transglycosylase activity
KOX_RS08370	COG4771	TonB-dependent receptor
KOX_RS08380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KOX_RS08390	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KOX_RS08410	COG2252	PERMEase
KOX_RS08415	COG0025	NhaP-type Na H and K H
KOX_RS08420	COG0583	DNA-binding transcription factor activity
KOX_RS08425	COG1380	Effector of murein hydrolase LrgA
KOX_RS08430	COG1346	cytolysis
KOX_RS08440	COG3121	Chaperone
KOX_RS08470	COG3162	membrane
KOX_RS08475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KOX_RS08480	COG1301	dicarboxylic acid transport
KOX_RS08485	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KOX_RS08490	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS08495	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS08500	COG1940	carbohydrate kinase activity
KOX_RS08505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KOX_RS08510	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS08515	COG1129	ABC transporter
KOX_RS08520	COG1879	ABC-type sugar transport system periplasmic component
KOX_RS08525	COG1737	Transcriptional regulator
KOX_RS08530	COG0698	ribose 5-phosphate isomerase
KOX_RS08540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KOX_RS08545	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
KOX_RS08550	COG3454	Phosphonate metabolism
KOX_RS08555	COG4778	phosphonate C-P lyase system protein PhnL
KOX_RS08560	COG4107	phosphonate C-P lyase system protein PhnK
KOX_RS08565	COG3627	carbon phosphorus lyase activity
KOX_RS08570	COG3626	phosphonate metabolism
KOX_RS08575	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
KOX_RS08580	COG3624	Phosphonate C-P lyase system protein PhnG
KOX_RS08585	COG2188	Transcriptional regulator
KOX_RS08590	COG2764	glyoxalase bleomycin resistance protein dioxygenase
KOX_RS08595	COG2824	Alkylphosphonate utilization operon protein PhnA
KOX_RS08615	COG0861	Integral membrane protein TerC family
KOX_RS08630	COG2249	NAD(P)H dehydrogenase (quinone) activity
KOX_RS08645	COG1309	transcriptional regulator
KOX_RS08660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KOX_RS08665	COG1027	Aspartate ammonia-lyase
KOX_RS08670	COG3030	protein affecting phage T7 exclusion by the F plasmid
KOX_RS08675	COG0531	amino acid
KOX_RS08685	COG0459	protein refolding
KOX_RS08725	COG3121	Chaperone
KOX_RS08740	COG1509	lysine 2,3-aminomutase activity
KOX_RS08760	COG2076	Multidrug Resistance protein
KOX_RS08765	COG3040	lipid binding
KOX_RS08780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KOX_RS08785	COG1053	succinate dehydrogenase
KOX_RS08800	COG3264	Mechanosensitive ion channel
KOX_RS08800	COG1511	domain protein
KOX_RS08815	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KOX_RS08820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS08840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KOX_RS08845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KOX_RS08845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KOX_RS08850	COG0802	atpase or kinase
KOX_RS08855	COG0860	N-Acetylmuramoyl-L-alanine amidase
KOX_RS08875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KOX_RS08880	COG0330	HflC and HflK could
KOX_RS08885	COG0330	HflC and HflK could
KOX_RS08890	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
KOX_RS08905	COG0557	exoribonuclease II activity
KOX_RS08910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOX_RS08920	COG1960	acyl-CoA dehydrogenase activity
KOX_RS08930	COG3650	response to hydrogen peroxide
KOX_RS08935	COG1073	alpha beta
KOX_RS08995	COG2965	DNA replication, synthesis of RNA primer
KOX_RS09000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KOX_RS09005	COG0359	binds to the 23S rRNA
KOX_RS09015	COG3061	Opacity-associated protein A
KOX_RS09020	COG0545	Peptidyl-prolyl cis-trans isomerase
KOX_RS09025	COG1113	amino acid transport
KOX_RS09035	COG0697	spore germination
KOX_RS09045	COG0702	epimerase
KOX_RS09050	COG1733	regulation of RNA biosynthetic process
KOX_RS09065	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KOX_RS09090	COG1253	flavin adenine dinucleotide binding
KOX_RS09100	COG0729	surface antigen
KOX_RS09105	COG2911	Protein conserved in bacteria
KOX_RS09110	COG2105	PFAM AIG2 family protein
KOX_RS09120	COG1879	ABC-type sugar transport system periplasmic component
KOX_RS09125	COG1129	ABC transporter
KOX_RS09130	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS09135	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS09145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KOX_RS09165	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS09175	COG0312	modulator of DNA gyrase
KOX_RS09210	COG3964	amidohydrolase
KOX_RS09225	COG2706	6-phosphogluconolactonase activity
KOX_RS09230	COG3711	transcriptional antiterminator
KOX_RS09230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS09250	COG0602	queuosine metabolic process
KOX_RS09270	COG1486	melibiose metabolic process
KOX_RS09275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS09280	COG0366	Alpha amylase catalytic
KOX_RS09285	COG1263	PTS System
KOX_RS09285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS09300	COG0251	oxidation-reduction process
KOX_RS09305	COG3397	chitin binding
KOX_RS09320	COG2731	YhcH YjgK YiaL family protein
KOX_RS09325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KOX_RS09350	COG0525	valine-tRNA ligase activity
KOX_RS09355	COG2927	DNA polymerase III (CHI subunit)
KOX_RS09365	COG0795	lipopolysaccharide-transporting ATPase activity
KOX_RS09370	COG0795	lipopolysaccharide-transporting ATPase activity
KOX_RS09375	COG0433	COG0433 Predicted ATPase
KOX_RS09390	COG3718	enzyme involved in inositol metabolism
KOX_RS09395	COG0837	glucose binding
KOX_RS09395	COG1737	Transcriptional regulator
KOX_RS09400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS09405	COG3962	Belongs to the TPP enzyme family
KOX_RS09415	COG1082	Xylose isomerase domain protein TIM barrel
KOX_RS09425	COG2814	Major facilitator Superfamily
KOX_RS09435	COG3842	ATPase activity
KOX_RS09440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KOX_RS09445	COG0395	ABC-type sugar transport system, permease component
KOX_RS09450	COG1175	transmembrane transport
KOX_RS09455	COG1064	alcohol dehydrogenase
KOX_RS09505	COG0582	viral genome integration into host DNA
KOX_RS09520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KOX_RS09530	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KOX_RS09565	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KOX_RS09580	COG3596	GTP binding
KOX_RS09595	COG2003	Belongs to the UPF0758 family
KOX_RS09655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KOX_RS09660	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS09665	COG4948	Mandelate Racemase Muconate Lactonizing
KOX_RS09670	COG0477	Major facilitator Superfamily
KOX_RS09680	COG0477	Major facilitator Superfamily
KOX_RS09695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KOX_RS09700	COG2850	peptidyl-arginine hydroxylation
KOX_RS09730	COG0842	Transport permease protein
KOX_RS09735	COG1129	ABC transporter
KOX_RS09735	COG0842	Transport permease protein
KOX_RS09740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS09745	COG3706	GGDEF domain
KOX_RS09755	COG0814	amino acid
KOX_RS09785	COG4869	propanediol catabolic process
KOX_RS09795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KOX_RS09800	COG1882	Formate acetyltransferase
KOX_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS09805	COG1454	alcohol dehydrogenase
KOX_RS09815	COG1454	alcohol dehydrogenase
KOX_RS09815	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS09875	COG0531	amino acid
KOX_RS09910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOX_RS09920	COG1566	PFAM secretion protein HlyD family protein
KOX_RS09930	COG0583	DNA-binding transcription factor activity
KOX_RS09935	COG3366	ferrous iron transmembrane transporter activity
KOX_RS09940	COG0700	Nucleoside recognition
KOX_RS09945	COG1473	amidohydrolase
KOX_RS09955	COG1924	4 iron, 4 sulfur cluster binding
KOX_RS09960	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
KOX_RS09975	COG1475	DNA binding
KOX_RS09980	COG2814	Major facilitator Superfamily
KOX_RS09985	COG2733	membrane
KOX_RS09990	COG1280	lysine exporter protein (LysE YggA)
KOX_RS10000	COG5464	transposase or invertase
KOX_RS10005	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS10020	COG0523	cobalamin synthesis protein
KOX_RS10025	COG2879	small protein
KOX_RS10030	COG1966	Carbon starvation protein
KOX_RS10035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KOX_RS10040	COG2368	4-hydroxyphenylacetate
KOX_RS10060	COG3971	2-oxopent-4-enoate hydratase activity
KOX_RS10070	COG3384	dioxygenase
KOX_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS10085	COG0179	Fumarylacetoacetate (FAA) hydrolase
KOX_RS10090	COG1846	Transcriptional regulator
KOX_RS10100	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KOX_RS10110	COG4145	pantothenate transmembrane transporter activity
KOX_RS10115	COG3734	2-keto-3-deoxy-galactonokinase
KOX_RS10120	COG0800	Aldolase
KOX_RS10125	COG1737	Transcriptional regulator
KOX_RS10135	COG0456	acetyltransferase
KOX_RS10140	COG2271	Major facilitator Superfamily
KOX_RS10145	COG1802	Transcriptional regulator
KOX_RS10150	COG1063	alcohol dehydrogenase
KOX_RS10160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KOX_RS10160	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KOX_RS10175	COG3715	PTS system
KOX_RS10180	COG3716	PTS system mannose fructose sorbose family IID component
KOX_RS10185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KOX_RS10190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KOX_RS10195	COG5464	transposase or invertase
KOX_RS10210	COG1484	DNA-dependent DNA replication
KOX_RS10225	COG2966	Psort location CytoplasmicMembrane, score
KOX_RS10235	COG2207	Transcriptional regulator
KOX_RS10240	COG2197	response regulator
KOX_RS10245	COG2197	response regulator
KOX_RS10250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KOX_RS10255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS10260	COG4114	ferric iron reductase
KOX_RS10265	COG3706	GGDEF domain
KOX_RS10295	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
KOX_RS10300	COG0456	acetyltransferase
KOX_RS10305	COG1011	Hydrolase
KOX_RS10315	COG2823	Periplasmic or secreted lipoprotein
KOX_RS10320	COG4667	esterase of the alpha-beta hydrolase superfamily
KOX_RS10325	COG0084	hydrolase, TatD family'
KOX_RS10330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KOX_RS10350	COG0813	purine-nucleoside phosphorylase activity
KOX_RS10360	COG3726	membrane protein affecting hemolysin expression
KOX_RS10365	COG0560	Phosphoserine phosphatase
KOX_RS10380	COG0488	(ABC) transporter
KOX_RS10385	COG0741	lytic transglycosylase activity
KOX_RS10405	COG3708	Transcriptional regulator
KOX_RS10405	COG2207	Transcriptional regulator
KOX_RS10410	COG3045	CreA protein
KOX_RS10415	COG0745	RESPONSE REGULATOR receiver
KOX_RS10420	COG2205	protein histidine kinase activity
KOX_RS10425	COG4452	Inner membrane protein CreD
KOX_RS10430	COG0745	RESPONSE REGULATOR receiver
KOX_RS10435	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KOX_RS10440	COG0527	aspartate kinase activity
KOX_RS10440	COG0460	homoserine dehydrogenase
KOX_RS10450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KOX_RS10460	COG1115	amino acid carrier protein
KOX_RS10465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KOX_RS10470	COG0521	Mo-molybdopterin cofactor biosynthetic process
KOX_RS10475	COG0477	Major facilitator Superfamily
KOX_RS10480	COG1584	GPR1 FUN34 yaaH family protein
KOX_RS10485	COG4735	regulation of single-species biofilm formation
KOX_RS10545	COG0583	DNA-binding transcription factor activity
KOX_RS10555	COG0196	riboflavin kinase activity
KOX_RS10570	COG1047	Peptidyl-prolyl cis-trans
KOX_RS10585	COG0583	DNA-binding transcription factor activity
KOX_RS10590	COG2828	Protein conserved in bacteria
KOX_RS10595	COG0471	metal ion transport
KOX_RS10600	COG0471	metal ion transport
KOX_RS10605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KOX_RS10615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KOX_RS10635	COG5016	pyruvate
KOX_RS10635	COG0511	ligase activity, forming carbon-carbon bonds
KOX_RS10725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KOX_RS10740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KOX_RS10755	COG3493	citrate carrier protein
KOX_RS10765	COG0564	pseudouridine synthase activity
KOX_RS10775	COG0417	DNA replication proofreading
KOX_RS10780	COG0235	Class ii aldolase
KOX_RS10800	COG0586	Pfam SNARE associated Golgi protein
KOX_RS10810	COG1178	ABC-type Fe3 transport system permease component
KOX_RS10825	COG2814	Major facilitator Superfamily
KOX_RS10830	COG2271	Major facilitator Superfamily
KOX_RS10835	COG0583	DNA-binding transcription factor activity
KOX_RS10845	COG0738	Major facilitator superfamily
KOX_RS10850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KOX_RS10875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KOX_RS10885	COG0028	Belongs to the TPP enzyme family
KOX_RS10895	COG1609	Transcriptional regulator
KOX_RS10915	COG0768	penicillin binding
KOX_RS10925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KOX_RS10940	COG0772	Belongs to the SEDS family
KOX_RS10965	COG0849	cell division
KOX_RS10970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KOX_RS10990	COG0494	nUDIX hydrolase
KOX_RS10995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KOX_RS11015	COG1459	type II secretion system
KOX_RS11020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KOX_RS11025	COG4969	Belongs to the N-Me-Phe pilin family
KOX_RS11040	COG3725	Membrane protein required for beta-lactamase induction
KOX_RS11045	COG3940	Belongs to the glycosyl hydrolase 43 family
KOX_RS11050	COG2211	Major facilitator Superfamily
KOX_RS11055	COG1113	amino acid transport
KOX_RS11060	COG2186	Transcriptional regulator
KOX_RS11065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KOX_RS11070	COG0508	dehydrogenase complex catalyzes the overall conversion of
KOX_RS11075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KOX_RS11090	COG3064	Membrane
KOX_RS11120	COG1349	DNA-binding transcription factor activity
KOX_RS11135	COG0545	Peptidyl-prolyl cis-trans isomerase
KOX_RS11150	COG2132	Multicopper oxidase
KOX_RS11155	COG4993	Dehydrogenase
KOX_RS11165	COG0288	reversible hydration of carbon dioxide
KOX_RS11170	COG1131	(ABC) transporter
KOX_RS11175	COG0842	Transport permease protein
KOX_RS11180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS11185	COG0726	polysaccharide deacetylase
KOX_RS11210	COG3188	usher protein
KOX_RS11215	COG3121	Chaperone
KOX_RS11220	COG3539	Fimbrial protein
KOX_RS11240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KOX_RS11245	COG0617	tRNA 3'-terminal CCA addition
KOX_RS11265	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KOX_RS11270	COG1643	Atp-dependent helicase
KOX_RS11360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KOX_RS11365	COG4774	siderophore transport
KOX_RS11370	COG1120	ATPase activity
KOX_RS11375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KOX_RS11380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS11385	COG5464	transposase or invertase
KOX_RS11405	COG2860	membrane
KOX_RS11425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KOX_RS11430	COG3835	regulator
KOX_RS11450	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KOX_RS11460	COG0024	Methionine aminopeptidase
KOX_RS11470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KOX_RS11495	COG0575	Belongs to the CDS family
KOX_RS11500	COG0750	zinc metalloprotease
KOX_RS11510	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
KOX_RS11515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KOX_RS11555	COG1982	Orn Lys Arg decarboxylase major
KOX_RS11560	COG0346	lactoylglutathione lyase activity
KOX_RS11570	COG4568	rho-dependent transcription termination
KOX_RS11580	COG4681	YaeQ
KOX_RS11585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KOX_RS11590	COG3015	lipoprotein NlpE involved in copper resistance
KOX_RS11595	COG0791	NLP P60 protein
KOX_RS11605	COG1720	tRNA m6t6A37 methyltransferase activity
KOX_RS11615	COG1464	Belongs to the NlpA lipoprotein family
KOX_RS11620	COG2011	ABC-type metal ion transport system permease component
KOX_RS11630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KOX_RS11670	COG0583	DNA-binding transcription factor activity
KOX_RS11675	COG2814	Major facilitator Superfamily
KOX_RS11685	COG2226	methyltransferase
KOX_RS11690	COG1388	LysM domain
KOX_RS11690	COG0741	lytic transglycosylase activity
KOX_RS11700	COG2226	methyltransferase
KOX_RS11720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KOX_RS11735	COG0121	glutamine amidotransferase
KOX_RS11740	COG3034	peptidoglycan biosynthetic process
KOX_RS11755	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KOX_RS11760	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KOX_RS11775	COG2991	Protein conserved in bacteria
KOX_RS11790	COG0454	-acetyltransferase
KOX_RS11795	COG2195	Cleaves the N-terminal amino acid of tripeptides
KOX_RS11815	COG1045	serine acetyltransferase
KOX_RS11830	COG0297	glycogen (starch) synthase activity
KOX_RS11830	COG0438	transferase activity, transferring glycosyl groups
KOX_RS11835	COG0438	transferase activity, transferring glycosyl groups
KOX_RS11840	COG0463	Glycosyl transferase, family 2
KOX_RS11860	COG1596	polysaccharide export
KOX_RS11870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KOX_RS11875	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS11895	COG2186	Transcriptional regulator
KOX_RS11900	COG0246	Mannitol dehydrogenase
KOX_RS11915	COG3153	acetyltransferase
KOX_RS11920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KOX_RS11940	COG0477	Major facilitator Superfamily
KOX_RS11950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KOX_RS11960	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KOX_RS11965	COG0402	S-adenosylhomocysteine deaminase activity
KOX_RS11970	COG2188	Transcriptional regulator
KOX_RS11980	COG2986	histidine ammonia-lyase
KOX_RS12010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KOX_RS12025	COG2814	Major facilitator Superfamily
KOX_RS12040	COG1309	transcriptional regulator
KOX_RS12045	COG2171	N-acyltransferase activity
KOX_RS12105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KOX_RS12110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KOX_RS12115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KOX_RS12120	COG0791	NLP P60 protein
KOX_RS12125	COG0583	DNA-binding transcription factor activity
KOX_RS12130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KOX_RS12145	COG3118	belongs to the thioredoxin family
KOX_RS12165	COG3639	organic phosphonate transmembrane transporter activity
KOX_RS12175	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KOX_RS12200	COG3188	usher protein
KOX_RS12215	COG0765	amino acid transport
KOX_RS12220	COG0765	amino acid transport
KOX_RS12225	COG1126	abc transporter atp-binding protein
KOX_RS12230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS12265	COG4302	ethanolamine ammonia-lyase activity
KOX_RS12270	COG4303	Ethanolamine ammonia lyase large subunit
KOX_RS12280	COG5434	Belongs to the glycosyl hydrolase 28 family
KOX_RS12285	COG0833	amino acid
KOX_RS12290	COG2040	homocysteine
KOX_RS12295	COG3842	ATPase activity
KOX_RS12305	COG1840	ABC-type Fe3 transport system, periplasmic component
KOX_RS12310	COG2271	Major facilitator Superfamily
KOX_RS12325	COG4521	taurine ABC transporter
KOX_RS12330	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KOX_RS12335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KOX_RS12340	COG2175	clavaminate synthase activity
KOX_RS12350	COG0113	porphobilinogen synthase activity
KOX_RS12355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KOX_RS12365	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KOX_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS12410	COG1609	Transcriptional regulator
KOX_RS12420	COG1785	Belongs to the alkaline phosphatase family
KOX_RS12430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KOX_RS12440	COG3416	Protein conserved in bacteria
KOX_RS12445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KOX_RS12455	COG4126	flavin adenine dinucleotide binding
KOX_RS12470	COG1940	carbohydrate kinase activity
KOX_RS12480	COG0419	ATPase involved in DNA repair
KOX_RS12485	COG0420	3'-5' exonuclease activity
KOX_RS12510	COG0366	Alpha amylase catalytic
KOX_RS12515	COG0583	DNA-binding transcription factor activity
KOX_RS12520	COG1335	isochorismatase
KOX_RS12530	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KOX_RS12545	COG0450	alkyl hydroperoxide reductase
KOX_RS12550	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
KOX_RS12565	COG1862	Preprotein translocase
KOX_RS12575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KOX_RS12600	COG4238	major outer membrane lipoprotein
KOX_RS12610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KOX_RS12610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KOX_RS12630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KOX_RS12635	COG0667	Aldo Keto reductase
KOX_RS12645	COG0142	geranyltranstransferase activity
KOX_RS12665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KOX_RS12675	COG2814	Major facilitator Superfamily
KOX_RS12680	COG0673	inositol 2-dehydrogenase activity
KOX_RS12685	COG2211	Major facilitator Superfamily
KOX_RS12715	COG1053	succinate dehydrogenase
KOX_RS12725	COG1414	Transcriptional regulator
KOX_RS12740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KOX_RS12745	COG1845	cytochrome c oxidase, subunit III
KOX_RS12750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KOX_RS12755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KOX_RS12760	COG2223	nitrite transmembrane transporter activity
KOX_RS12765	COG3056	Lipoprotein
KOX_RS12770	COG0271	Belongs to the BolA IbaG family
KOX_RS12790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KOX_RS12795	COG0776	regulation of translation
KOX_RS12800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KOX_RS12805	COG1555	photosystem II stabilization
KOX_RS12810	COG0824	Thioesterase
KOX_RS12820	COG4533	DNA binding
KOX_RS12835	COG1522	sequence-specific DNA binding
KOX_RS12840	COG1132	(ABC) transporter
KOX_RS12845	COG1132	(ABC) transporter
KOX_RS12855	COG0347	Belongs to the P(II) protein family
KOX_RS12860	COG0004	ammonium transporteR
KOX_RS12865	COG1946	Acyl-CoA thioesterase
KOX_RS12870	COG3126	Type III secretion system lipoprotein chaperone (YscW)
KOX_RS12875	COG3695	enzyme binding
KOX_RS12900	COG2364	Membrane
KOX_RS12905	COG5507	3-demethylubiquinone-9 3-methyltransferase
KOX_RS12920	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KOX_RS12930	COG2182	Extracellular solute-binding protein
KOX_RS12935	COG1175	transmembrane transport
KOX_RS12940	COG3833	ABC-type maltose transport systems, permease component
KOX_RS12945	COG3867	Arabinogalactan endo-beta-1,4-galactanase
KOX_RS12950	COG1874	Beta-galactosidase
KOX_RS12955	COG1263	PTS System
KOX_RS12955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS12975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KOX_RS13010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOX_RS13015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS13020	COG1309	transcriptional regulator
KOX_RS13025	COG3264	Mechanosensitive ion channel
KOX_RS13025	COG1196	nuclear chromosome segregation
KOX_RS13035	COG3923	Primosomal replication protein n
KOX_RS13040	COG2832	Protein of unknown function (DUF454)
KOX_RS13050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KOX_RS13080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS13085	COG4651	solute:proton antiporter activity
KOX_RS13085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KOX_RS13090	COG2223	nitrite transmembrane transporter activity
KOX_RS13100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KOX_RS13105	COG3735	TraB family
KOX_RS13125	COG0811	peptide transport
KOX_RS13155	COG1585	Membrane protein implicated in regulation of membrane protease activity
KOX_RS13160	COG0330	HflC and HflK could
KOX_RS13165	COG4619	ABC transporter
KOX_RS13170	COG0390	transport system, permease component
KOX_RS13175	COG3118	belongs to the thioredoxin family
KOX_RS13180	COG0300	oxidoreductase activity
KOX_RS13185	COG2755	lipolytic protein G-D-S-L family
KOX_RS13190	COG4181	ATPase activity
KOX_RS13195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KOX_RS13215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KOX_RS13220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KOX_RS13230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KOX_RS13240	COG2501	S4 domain
KOX_RS13265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KOX_RS13275	COG0583	DNA-binding transcription factor activity
KOX_RS13285	COG3710	Transcriptional regulator
KOX_RS13290	COG0531	amino acid
KOX_RS13300	COG3104	oligopeptide transport
KOX_RS13315	COG2367	Beta-lactamase
KOX_RS13325	COG0673	inositol 2-dehydrogenase activity
KOX_RS13340	COG1129	ABC transporter
KOX_RS13345	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS13350	COG2190	(PTS) system
KOX_RS13350	COG1263	PTS System
KOX_RS13350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS13355	COG2723	6-phospho-beta-galactosidase activity
KOX_RS13360	COG3711	transcriptional antiterminator
KOX_RS13370	COG3550	peptidyl-serine autophosphorylation
KOX_RS13400	COG1120	ATPase activity
KOX_RS13405	COG4139	cobalamin transport
KOX_RS13425	COG1473	amidohydrolase
KOX_RS13430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS13435	COG0667	Aldo Keto reductase
KOX_RS13445	COG1113	amino acid transport
KOX_RS13450	COG2211	Major facilitator Superfamily
KOX_RS13470	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS13475	COG0583	DNA-binding transcription factor activity
KOX_RS13480	COG2771	luxR family
KOX_RS13495	COG3188	usher protein
KOX_RS13515	COG0494	nUDIX hydrolase
KOX_RS13525	COG0668	transmembrane transport
KOX_RS13530	COG0477	Major facilitator Superfamily
KOX_RS13540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KOX_RS13540	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KOX_RS13545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS13545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS13550	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS13555	COG3715	PTS system
KOX_RS13560	COG3716	PTS system mannose fructose sorbose family IID component
KOX_RS13565	COG1621	beta-fructofuranosidase activity
KOX_RS13635	COG0778	Nitroreductase
KOX_RS13640	COG2315	Protein conserved in bacteria
KOX_RS13660	COG4774	siderophore transport
KOX_RS13690	COG3698	Phosphodiester glycosidase
KOX_RS13710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS13715	COG4608	Belongs to the ABC transporter superfamily
KOX_RS13720	COG0444	Belongs to the ABC transporter superfamily
KOX_RS13725	COG0154	amidase activity
KOX_RS13750	COG1280	lysine exporter protein (LysE YggA)
KOX_RS13765	COG0765	amino acid transport
KOX_RS13770	COG0765	amino acid transport
KOX_RS13780	COG4221	oxidoreductase activity
KOX_RS13785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KOX_RS13790	COG4608	Belongs to the ABC transporter superfamily
KOX_RS13795	COG0444	Belongs to the ABC transporter superfamily
KOX_RS13800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS13805	COG0601	transmembrane transport
KOX_RS13835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KOX_RS13845	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS13855	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS13860	COG1129	ABC transporter
KOX_RS13870	COG1879	ABC-type sugar transport system periplasmic component
KOX_RS13875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KOX_RS13880	COG2390	Transcriptional regulator
KOX_RS13885	COG3959	Transketolase, thiamine diphosphate binding domain
KOX_RS13890	COG3958	Transketolase
KOX_RS13895	COG2977	Belongs to the P-Pant transferase superfamily
KOX_RS13900	COG4771	TonB-dependent receptor
KOX_RS13905	COG2382	esterase
KOX_RS13910	COG3251	PFAM MbtH domain protein
KOX_RS13915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KOX_RS13915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOX_RS13920	COG1120	ATPase activity
KOX_RS13925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS13930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS13945	COG4592	Periplasmic binding protein
KOX_RS13950	COG1169	isochorismate synthase
KOX_RS13955	COG1021	2,3-dihydroxybenzoate-AMP ligase
KOX_RS13960	COG1535	isochorismatase
KOX_RS13960	COG3433	isochorismatase activity
KOX_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS13975	COG1966	Carbon starvation protein
KOX_RS13980	COG2879	small protein
KOX_RS13990	COG0371	Dehydrogenase
KOX_RS13995	COG1129	ABC transporter
KOX_RS14000	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS14030	COG2271	Major facilitator Superfamily
KOX_RS14035	COG0483	inositol monophosphate 1-phosphatase activity
KOX_RS14045	COG0402	S-adenosylhomocysteine deaminase activity
KOX_RS14055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KOX_RS14070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KOX_RS14080	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS14085	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS14090	COG1129	ABC transporter
KOX_RS14105	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KOX_RS14110	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KOX_RS14115	COG0436	Aminotransferase
KOX_RS14120	COG1475	DNA binding
KOX_RS14125	COG3969	phosphoadenosine phosphosulfate
KOX_RS14130	COG0583	DNA-binding transcription factor activity
KOX_RS14140	COG3634	alkyl hydroperoxide reductase activity
KOX_RS14150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KOX_RS14155	COG3719	Belongs to the RNase T2 family
KOX_RS14160	COG3069	C4-dicarboxylate transmembrane transporter activity
KOX_RS14180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KOX_RS14185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KOX_RS14195	COG0583	DNA-binding transcription factor activity
KOX_RS14210	COG1686	Belongs to the peptidase S11 family
KOX_RS14215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KOX_RS14220	COG0772	Belongs to the SEDS family
KOX_RS14225	COG0768	penicillin binding
KOX_RS14235	COG0799	negative regulation of ribosome biogenesis
KOX_RS14240	COG0406	alpha-ribazole phosphatase activity
KOX_RS14250	COG1466	dna polymerase III delta subunit
KOX_RS14265	COG2888	peptidyl-tyrosine sulfation
KOX_RS14275	COG2831	hemolysin activation secretion protein
KOX_RS14280	COG1126	abc transporter atp-binding protein
KOX_RS14285	COG0765	amino acid transport
KOX_RS14290	COG0765	amino acid transport
KOX_RS14305	COG4535	Mg2 and Co2 transporter CorC
KOX_RS14310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KOX_RS14315	COG1702	phosphate starvation-inducible protein PhoH
KOX_RS14325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOX_RS14365	COG0367	asparagine synthase
KOX_RS14375	COG0647	UMP catabolic process
KOX_RS14380	COG1940	carbohydrate kinase activity
KOX_RS14380	COG1846	Transcriptional regulator
KOX_RS14385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KOX_RS14425	COG1053	succinate dehydrogenase
KOX_RS14430	COG0583	DNA-binding transcription factor activity
KOX_RS14435	COG0735	belongs to the Fur family
KOX_RS14450	COG0596	Alpha beta hydrolase
KOX_RS14460	COG0033	Phosphoglucomutase
KOX_RS14470	COG1349	DNA-binding transcription factor activity
KOX_RS14475	COG1063	alcohol dehydrogenase
KOX_RS14480	COG1879	ABC-type sugar transport system periplasmic component
KOX_RS14485	COG1129	ABC transporter
KOX_RS14490	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS14495	COG1070	Carbohydrate kinase
KOX_RS14500	COG3623	hexulose-6-phosphate isomerase
KOX_RS14510	COG0745	RESPONSE REGULATOR receiver
KOX_RS14515	COG2205	protein histidine kinase activity
KOX_RS14545	COG0415	Belongs to the DNA photolyase family
KOX_RS14555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KOX_RS14560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KOX_RS14565	COG1984	allophanate hydrolase subunit 2
KOX_RS14595	COG0372	Belongs to the citrate synthase family
KOX_RS14605	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KOX_RS14610	COG1053	succinate dehydrogenase
KOX_RS14615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KOX_RS14620	COG0567	Dehydrogenase, E1 component
KOX_RS14625	COG0508	dehydrogenase complex catalyzes the overall conversion of
KOX_RS14635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KOX_RS14645	COG0583	DNA-binding transcription factor activity
KOX_RS14660	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS14660	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS14670	COG1301	dicarboxylic acid transport
KOX_RS14685	COG3799	methylaspartate ammonia-lyase activity
KOX_RS14690	COG4865	methylaspartate mutase activity
KOX_RS14700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KOX_RS14705	COG1271	oxidase subunit
KOX_RS14710	COG1294	oxidase, subunit
KOX_RS14715	COG3790	cyd operon protein YbgE
KOX_RS14720	COG0824	Thioesterase
KOX_RS14725	COG0811	peptide transport
KOX_RS14730	COG0848	biopolymer transport protein
KOX_RS14735	COG3064	Membrane
KOX_RS14745	COG2885	chlorophyll binding
KOX_RS14750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
KOX_RS14780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KOX_RS14800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KOX_RS14810	COG2017	converts alpha-aldose to the beta-anomer
KOX_RS14820	COG1085	galactose-1-phosphate uridylyltransferase
KOX_RS14825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KOX_RS14830	COG1119	ATPase activity
KOX_RS14835	COG2005	Transcriptional regulator
KOX_RS14835	COG3585	molybdate ion transport
KOX_RS14845	COG0725	ABC transporter, periplasmic molybdate-binding protein
KOX_RS14850	COG4149	molybdate abc transporter
KOX_RS14860	COG0561	phosphatase activity
KOX_RS14895	COG2200	EAL domain
KOX_RS14900	COG0789	Transcriptional regulator
KOX_RS14915	COG4677	pectinesterase activity
KOX_RS14945	COG1881	PFAM PEBP family protein
KOX_RS14950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KOX_RS14965	COG2226	methyltransferase
KOX_RS14990	COG0745	RESPONSE REGULATOR receiver
KOX_RS15010	COG0521	Mo-molybdopterin cofactor biosynthetic process
KOX_RS15020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KOX_RS15025	COG0314	molybdopterin synthase activity
KOX_RS15030	COG0670	Belongs to the BI1 family
KOX_RS15035	COG0392	lysyltransferase activity
KOX_RS15040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KOX_RS15045	COG3568	Endonuclease Exonuclease Phosphatase
KOX_RS15055	COG0842	Transport permease protein
KOX_RS15060	COG0842	Transport permease protein
KOX_RS15065	COG1131	(ABC) transporter
KOX_RS15070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS15075	COG1309	transcriptional regulator
KOX_RS15080	COG0583	DNA-binding transcription factor activity
KOX_RS15085	COG2271	Major facilitator Superfamily
KOX_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS15095	COG3959	Transketolase, thiamine diphosphate binding domain
KOX_RS15100	COG3958	Transketolase
KOX_RS15105	COG0513	Belongs to the DEAD box helicase family
KOX_RS15115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KOX_RS15125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KOX_RS15135	COG4774	siderophore transport
KOX_RS15150	COG0668	transmembrane transport
KOX_RS15155	COG1126	abc transporter atp-binding protein
KOX_RS15160	COG0765	amino acid transport
KOX_RS15165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS15180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KOX_RS15185	COG2194	sulfuric ester hydrolase activity
KOX_RS15200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KOX_RS15205	COG0667	Aldo Keto reductase
KOX_RS15210	COG2723	6-phospho-beta-galactosidase activity
KOX_RS15215	COG2188	Transcriptional regulator
KOX_RS15220	COG1376	ErfK ybiS ycfS ynhG family protein
KOX_RS15230	COG0488	(ABC) transporter
KOX_RS15240	COG2271	Major facilitator Superfamily
KOX_RS15245	COG1609	Transcriptional regulator
KOX_RS15255	COG0561	phosphatase activity
KOX_RS15260	COG1882	Formate acetyltransferase
KOX_RS15265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KOX_RS15270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KOX_RS15275	COG0303	'Molybdopterin
KOX_RS15280	COG1446	asparaginase
KOX_RS15290	COG0747	negative chemotaxis
KOX_RS15325	COG2133	pyrroloquinoline quinone binding
KOX_RS15330	COG0625	glutathione transferase activity
KOX_RS15335	COG0582	viral genome integration into host DNA
KOX_RS15385	COG1396	sequence-specific DNA binding
KOX_RS15395	COG1846	Transcriptional regulator
KOX_RS15465	COG0484	heat shock protein binding
KOX_RS15485	COG3179	chitinase
KOX_RS15540	COG0740	serine-type endopeptidase activity
KOX_RS15580	COG1196	nuclear chromosome segregation
KOX_RS15615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KOX_RS15625	COG1686	Belongs to the peptidase S11 family
KOX_RS15630	COG1349	DNA-binding transcription factor activity
KOX_RS15635	COG0671	phosphoesterase, PA-phosphatase related
KOX_RS15640	COG2814	Major facilitator Superfamily
KOX_RS15645	COG0561	phosphatase activity
KOX_RS15650	COG0738	Major facilitator superfamily
KOX_RS15655	COG3226	Transcriptional regulator
KOX_RS15680	COG0569	domain protein
KOX_RS15680	COG2985	domain, Protein
KOX_RS15700	COG0778	Nitroreductase
KOX_RS15715	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KOX_RS15720	COG3842	ATPase activity
KOX_RS15725	COG1176	ABC-type spermidine putrescine transport system, permease component I
KOX_RS15730	COG1177	transmembrane transport
KOX_RS15745	COG0745	RESPONSE REGULATOR receiver
KOX_RS15750	COG5002	protein histidine kinase activity
KOX_RS15755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS15760	COG4160	amino acid transport
KOX_RS15765	COG4215	(ABC) transporter
KOX_RS15770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS15775	COG1126	abc transporter atp-binding protein
KOX_RS15785	COG0393	Putative heavy-metal-binding
KOX_RS15790	COG3023	N-Acetylmuramoyl-L-alanine amidase
KOX_RS15795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KOX_RS15800	COG0702	epimerase
KOX_RS15805	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
KOX_RS15810	COG0028	Belongs to the TPP enzyme family
KOX_RS15820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KOX_RS15830	COG2431	L-lysine efflux transmembrane transporter activity
KOX_RS15835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KOX_RS15840	COG3593	DNA synthesis involved in DNA repair
KOX_RS15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS15855	COG1278	Cold shock
KOX_RS15865	COG0542	response to heat
KOX_RS15870	COG1518	maintenance of DNA repeat elements
KOX_RS15875	COG1203	CRISPR-associated helicase, Cas3
KOX_RS15900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KOX_RS15910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KOX_RS15915	COG4988	ABC transporter
KOX_RS15920	COG0492	ferredoxin-NADP+ reductase activity
KOX_RS15940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KOX_RS15950	COG0243	molybdopterin cofactor binding
KOX_RS15955	COG0437	4 iron, 4 sulfur cluster binding
KOX_RS15960	COG3302	dmso reductase anchor subunit
KOX_RS15965	COG0477	Major facilitator Superfamily
KOX_RS15970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS15975	COG3958	Transketolase
KOX_RS15980	COG3959	Transketolase, thiamine diphosphate binding domain
KOX_RS16000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KOX_RS16005	COG1882	Formate acetyltransferase
KOX_RS16010	COG2116	formate transmembrane transporter activity
KOX_RS16015	COG1944	ATP diphosphatase activity
KOX_RS16020	COG2323	membrane
KOX_RS16040	COG0539	negative regulation of cytoplasmic translation
KOX_RS16050	COG2333	competence protein COMEC
KOX_RS16050	COG0658	competence protein
KOX_RS16055	COG1132	(ABC) transporter
KOX_RS16065	COG3214	Protein conserved in bacteria
KOX_RS16080	COG3173	Aminoglycoside phosphotransferase
KOX_RS16085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KOX_RS16090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KOX_RS16100	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KOX_RS16110	COG2989	Protein conserved in bacteria
KOX_RS16120	COG3108	Peptidase M15
KOX_RS16125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KOX_RS16130	COG1448	Aminotransferase
KOX_RS16135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KOX_RS16150	COG0308	aminopeptidase N
KOX_RS16155	COG1116	anion transmembrane transporter activity
KOX_RS16160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KOX_RS16165	COG0431	NADPH-dependent FMN reductase
KOX_RS16180	COG3217	Mosc domain protein beta barrel domain protein
KOX_RS16180	COG0633	Ferredoxin
KOX_RS16190	COG0488	(ABC) transporter
KOX_RS16195	COG2995	paraquat-inducible protein a
KOX_RS16200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KOX_RS16200	COG3008	intermembrane lipid transfer
KOX_RS16205	COG3009	Protein conserved in bacteria
KOX_RS16215	COG1067	ATP-dependent peptidase activity
KOX_RS16235	COG3070	regulator of competence-specific genes
KOX_RS16240	COG1289	transmembrane transporter activity
KOX_RS16245	COG3304	Inner membrane component domain
KOX_RS16250	COG0210	DNA helicase
KOX_RS16260	COG1832	CoA-binding protein
KOX_RS16280	COG2274	protein secretion by the type I secretion system
KOX_RS16285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS16290	COG0438	transferase activity, transferring glycosyl groups
KOX_RS16315	COG1881	PFAM PEBP family protein
KOX_RS16320	COG2207	Transcriptional regulator
KOX_RS16335	COG0670	Belongs to the BI1 family
KOX_RS16360	COG4821	SIS domain
KOX_RS16370	COG4821	SIS domain
KOX_RS16375	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS16380	COG3716	PTS system mannose fructose sorbose family IID component
KOX_RS16385	COG3715	PTS system
KOX_RS16395	COG2188	Transcriptional regulator
KOX_RS16400	COG0436	Aminotransferase
KOX_RS16405	COG0504	CTP synthase activity
KOX_RS16410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KOX_RS16415	COG0006	proline dipeptidase activity
KOX_RS16425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOX_RS16430	COG1126	abc transporter atp-binding protein
KOX_RS16435	COG0765	amino acid transport
KOX_RS16440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS16450	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS16465	COG2207	Transcriptional regulator
KOX_RS16470	COG1486	melibiose metabolic process
KOX_RS16485	COG0300	oxidoreductase activity
KOX_RS16490	COG0604	alcohol dehydrogenase
KOX_RS16510	COG0814	amino acid
KOX_RS16515	COG0156	8-amino-7-oxononanoate synthase activity
KOX_RS16545	COG1126	abc transporter atp-binding protein
KOX_RS16550	COG0765	amino acid transport
KOX_RS16570	COG0583	DNA-binding transcription factor activity
KOX_RS16575	COG2828	Protein conserved in bacteria
KOX_RS16580	COG2814	Major facilitator Superfamily
KOX_RS16585	COG0179	Fumarylacetoacetate (FAA) hydrolase
KOX_RS16590	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
KOX_RS16595	COG3052	prosthetic group binding
KOX_RS16615	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KOX_RS16630	COG0471	metal ion transport
KOX_RS16635	COG1278	Cold shock
KOX_RS16640	COG1278	Cold shock
KOX_RS16650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOX_RS16660	COG0745	RESPONSE REGULATOR receiver
KOX_RS16665	COG5002	protein histidine kinase activity
KOX_RS16680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS16690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KOX_RS16760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOX_RS16765	COG2233	PERMEase
KOX_RS16775	COG2351	hydroxyisourate hydrolase activity
KOX_RS16780	COG0402	S-adenosylhomocysteine deaminase activity
KOX_RS16785	COG1953	Uracil, thiamine, allantoin
KOX_RS16840	COG0765	amino acid transport
KOX_RS16850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KOX_RS16865	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KOX_RS16875	COG0287	Prephenate dehydrogenase
KOX_RS16875	COG1605	Chorismate mutase
KOX_RS16885	COG3706	GGDEF domain
KOX_RS16890	COG2207	Transcriptional regulator
KOX_RS16900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS16905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KOX_RS16910	COG1882	Formate acetyltransferase
KOX_RS16915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS16920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS16925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS16925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KOX_RS16925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS16930	COG0473	3-isopropylmalate dehydrogenase activity
KOX_RS16935	COG0583	DNA-binding transcription factor activity
KOX_RS16940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KOX_RS16945	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS16950	COG1917	Cupin 2, conserved barrel domain protein
KOX_RS16950	COG1396	sequence-specific DNA binding
KOX_RS16955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KOX_RS16960	COG0174	glutamine synthetase
KOX_RS16965	COG0531	amino acid
KOX_RS16995	COG3729	General stress protein
KOX_RS17000	COG2233	PERMEase
KOX_RS17035	COG1309	transcriptional regulator
KOX_RS17050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOX_RS17060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KOX_RS17070	COG2822	iron ion transport
KOX_RS17080	COG1702	phosphate starvation-inducible protein PhoH
KOX_RS17100	COG5002	protein histidine kinase activity
KOX_RS17100	COG3850	Histidine kinase
KOX_RS17120	COG1335	isochorismatase
KOX_RS17130	COG0583	DNA-binding transcription factor activity
KOX_RS17150	COG3381	protein complex oligomerization
KOX_RS17190	COG5645	(Lipo)protein
KOX_RS17205	COG1560	Kdo2-lipid A biosynthetic process
KOX_RS17240	COG2999	glutathione oxidoreductase activity
KOX_RS17250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KOX_RS17260	COG0673	inositol 2-dehydrogenase activity
KOX_RS17270	COG2814	Major facilitator Superfamily
KOX_RS17275	COG0583	DNA-binding transcription factor activity
KOX_RS17280	COG1530	ribonuclease E activity
KOX_RS17295	COG0424	maF-like protein
KOX_RS17300	COG1399	metal-binding, possibly nucleic acid-binding protein
KOX_RS17320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KOX_RS17335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOX_RS17340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KOX_RS17345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KOX_RS17355	COG0470	DNA polymerase III
KOX_RS17360	COG0084	hydrolase, TatD family'
KOX_RS17370	COG4773	Receptor
KOX_RS17375	COG0537	adenosine 5'-monophosphoramidase activity
KOX_RS17380	COG5633	Lipoprotein
KOX_RS17405	COG1252	NADH dehydrogenase
KOX_RS17410	COG3134	Outer membrane lipoprotein
KOX_RS17420	COG1309	transcriptional regulator
KOX_RS17430	COG1376	ErfK ybiS ycfS ynhG family protein
KOX_RS17430	COG1388	LysM domain
KOX_RS17435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KOX_RS17440	COG4591	ABC-type transport system involved in lipoprotein release permease component
KOX_RS17445	COG1136	(ABC) transporter
KOX_RS17450	COG4591	ABC-type transport system involved in lipoprotein release permease component
KOX_RS17460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KOX_RS17465	COG2390	Transcriptional regulator
KOX_RS17480	COG3395	kinase activity
KOX_RS17495	COG0698	ribose 5-phosphate isomerase
KOX_RS17500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KOX_RS17505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KOX_RS17520	COG1177	transmembrane transport
KOX_RS17540	COG2850	peptidyl-arginine hydroxylation
KOX_RS17545	COG2205	protein histidine kinase activity
KOX_RS17550	COG0745	RESPONSE REGULATOR receiver
KOX_RS17560	COG2814	Major facilitator Superfamily
KOX_RS17565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KOX_RS17585	COG1187	pseudouridine synthase activity
KOX_RS17590	COG0538	isocitrate dehydrogenase activity
KOX_RS17595	COG0582	viral genome integration into host DNA
KOX_RS17605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KOX_RS17670	COG1403	HNH endonuclease
KOX_RS17695	COG3772	lysozyme
KOX_RS17725	COG1802	Transcriptional regulator
KOX_RS17725	COG4626	Terminase
KOX_RS17740	COG0616	signal peptide processing
KOX_RS17820	COG3706	GGDEF domain
KOX_RS17825	COG5001	Diguanylate cyclase
KOX_RS17825	COG3300	MHYT domain
KOX_RS17830	COG3706	GGDEF domain
KOX_RS17835	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KOX_RS17845	COG1120	ATPase activity
KOX_RS17850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS17855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS17860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KOX_RS17865	COG4772	TonB-dependent receptor
KOX_RS17870	COG3712	iron ion homeostasis
KOX_RS17875	COG1595	DNA-templated transcription, initiation
KOX_RS17880	COG2226	methyltransferase
KOX_RS17885	COG1560	Kdo2-lipid A biosynthetic process
KOX_RS17895	COG3182	Iron-regulated membrane protein
KOX_RS17905	COG2203	Gaf domain
KOX_RS17905	COG2199	diguanylate cyclase activity
KOX_RS17910	COG3042	response to heat
KOX_RS17915	COG3189	MarR family transcriptional regulator
KOX_RS17920	COG1683	Conserved Protein
KOX_RS17925	COG0504	CTP synthase activity
KOX_RS17930	COG2807	transmembrane transport
KOX_RS17935	COG2207	Transcriptional regulator
KOX_RS17945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KOX_RS17950	COG2199	diguanylate cyclase activity
KOX_RS17960	COG0859	PFAM glycosyl transferase family 9
KOX_RS17970	COG2766	serine protein kinase
KOX_RS17975	COG3713	MltA-interacting MipA family protein
KOX_RS17980	COG0656	L-ascorbic acid biosynthetic process
KOX_RS18000	COG3139	Protein of unknown function (DUF1315)
KOX_RS18015	COG1063	alcohol dehydrogenase
KOX_RS18020	COG2271	Major facilitator Superfamily
KOX_RS18025	COG1063	alcohol dehydrogenase
KOX_RS18030	COG0191	fructose-bisphosphate aldolase activity
KOX_RS18035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS18040	COG0667	Aldo Keto reductase
KOX_RS18045	COG1349	DNA-binding transcription factor activity
KOX_RS18050	COG2814	Major facilitator Superfamily
KOX_RS18055	COG1335	isochorismatase
KOX_RS18060	COG0252	asparaginase activity
KOX_RS18065	COG0616	signal peptide processing
KOX_RS18070	COG0778	Nitroreductase
KOX_RS18080	COG0709	Synthesizes selenophosphate from selenide and ATP
KOX_RS18085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KOX_RS18095	COG0494	nUDIX hydrolase
KOX_RS18100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KOX_RS18105	COG2897	thiosulfate sulfurtransferase activity
KOX_RS18110	COG4136	ATPase activity
KOX_RS18115	COG4135	transport system, permease component
KOX_RS18120	COG4134	Bacterial extracellular solute-binding protein
KOX_RS18125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOX_RS18130	COG0398	Pfam SNARE associated Golgi protein
KOX_RS18135	COG0398	Pfam SNARE associated Golgi protein
KOX_RS18140	COG0708	Exodeoxyribonuclease III
KOX_RS18150	COG3138	arginine N-succinyltransferase
KOX_RS18170	COG3678	ATP-independent chaperone mediated protein folding
KOX_RS18175	COG1704	LemA family
KOX_RS18180	COG4907	membrane protein (DUF2207)
KOX_RS18185	COG0322	excinuclease ABC activity
KOX_RS18195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KOX_RS18200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS18205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS18210	COG1447	Phosphotransferase system cellobiose-specific component IIA
KOX_RS18215	COG2169	Transcriptional regulator
KOX_RS18215	COG1917	Cupin 2, conserved barrel domain protein
KOX_RS18220	COG1486	melibiose metabolic process
KOX_RS18230	COG0753	catalase activity
KOX_RS18240	COG1823	symporter activity
KOX_RS18245	COG1988	membrane-bound metal-dependent
KOX_RS18250	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS18255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOX_RS18275	COG0038	chloride channel
KOX_RS18290	COG3047	cAMP biosynthetic process
KOX_RS18305	COG2207	Transcriptional regulator
KOX_RS18305	COG3708	Transcriptional regulator
KOX_RS18315	COG0583	DNA-binding transcription factor activity
KOX_RS18340	COG0134	indole-3-glycerol-phosphate synthase activity
KOX_RS18340	COG0135	phosphoribosylanthranilate isomerase activity
KOX_RS18345	COG0512	Glutamine amidotransferase of anthranilate synthase
KOX_RS18345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KOX_RS18350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KOX_RS18360	COG0009	L-threonylcarbamoyladenylate synthase
KOX_RS18365	COG1187	pseudouridine synthase activity
KOX_RS18370	COG2211	Major facilitator Superfamily
KOX_RS18375	COG1472	Belongs to the glycosyl hydrolase 3 family
KOX_RS18380	COG2207	Transcriptional regulator
KOX_RS18390	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS18395	COG0616	signal peptide processing
KOX_RS18415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KOX_RS18425	COG0671	phosphoesterase, PA-phosphatase related
KOX_RS18430	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
KOX_RS18435	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KOX_RS18445	COG0023	Translation Initiation Factor
KOX_RS18455	COG1349	DNA-binding transcription factor activity
KOX_RS18470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOX_RS18470	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOX_RS18475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KOX_RS18480	COG4172	Belongs to the ABC transporter superfamily
KOX_RS18490	COG4171	peptide transport system, permease
KOX_RS18500	COG4166	transmembrane transport
KOX_RS18515	COG1473	amidohydrolase
KOX_RS18525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KOX_RS18530	COG1842	Phage shock protein A
KOX_RS18540	COG1983	PspC domain protein
KOX_RS18550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KOX_RS18555	COG3106	COG3106 Predicted ATPase
KOX_RS18570	COG3180	Ammonia monooxygenase
KOX_RS18575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KOX_RS18580	COG4948	Mandelate Racemase Muconate Lactonizing
KOX_RS18585	COG2866	Carboxypeptidase
KOX_RS18590	COG4166	transmembrane transport
KOX_RS18605	COG2011	ABC-type metal ion transport system permease component
KOX_RS18610	COG1464	Belongs to the NlpA lipoprotein family
KOX_RS18615	COG2814	Major facilitator Superfamily
KOX_RS18630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KOX_RS18645	COG2188	Transcriptional regulator
KOX_RS18650	COG1605	Chorismate mutase
KOX_RS18655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS18660	COG1126	abc transporter atp-binding protein
KOX_RS18665	COG0765	amino acid transport
KOX_RS18675	COG1045	serine acetyltransferase
KOX_RS18680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KOX_RS18700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KOX_RS18705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KOX_RS18715	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KOX_RS18725	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KOX_RS18730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KOX_RS18745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KOX_RS18755	COG0693	protein deglycase activity
KOX_RS18860	COG3507	Belongs to the glycosyl hydrolase 43 family
KOX_RS18865	COG2211	Major facilitator Superfamily
KOX_RS18870	COG4580	involved in the transport of maltose and maltodextrins
KOX_RS18875	COG3272	Protein of unknown function (DUF1722)
KOX_RS18885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KOX_RS18900	COG0300	oxidoreductase activity
KOX_RS18910	COG0789	Transcriptional regulator
KOX_RS18935	COG0583	DNA-binding transcription factor activity
KOX_RS18945	COG0300	oxidoreductase activity
KOX_RS18965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KOX_RS18965	COG2885	chlorophyll binding
KOX_RS18970	COG3477	response to acidic pH
KOX_RS18990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KOX_RS18995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KOX_RS19000	COG0673	inositol 2-dehydrogenase activity
KOX_RS19005	COG1349	DNA-binding transcription factor activity
KOX_RS19020	COG0513	Belongs to the DEAD box helicase family
KOX_RS19045	COG0589	response to stress
KOX_RS19055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KOX_RS19060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOX_RS19060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KOX_RS19060	COG1013	pyruvate-flavodoxin oxidoreductase activity
KOX_RS19060	COG0674	pyruvate-flavodoxin oxidoreductase activity
KOX_RS19135	COG3042	response to heat
KOX_RS19140	COG3187	Heat shock protein
KOX_RS19145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KOX_RS19150	COG0586	Pfam SNARE associated Golgi protein
KOX_RS19155	COG2911	Protein conserved in bacteria
KOX_RS19165	COG3784	Protein of unknown function (DUF1318)
KOX_RS19170	COG2207	Transcriptional regulator
KOX_RS19175	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS19190	COG5285	phytanoyl-CoA dioxygenase
KOX_RS19195	COG1126	abc transporter atp-binding protein
KOX_RS19200	COG0583	DNA-binding transcription factor activity
KOX_RS19205	COG2072	flavoprotein involved in K transport
KOX_RS19235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KOX_RS19265	COG1566	PFAM secretion protein HlyD family protein
KOX_RS19280	COG2207	Transcriptional regulator
KOX_RS19285	COG2207	Transcriptional regulator
KOX_RS19285	COG3708	Transcriptional regulator
KOX_RS19290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS19305	COG0406	alpha-ribazole phosphatase activity
KOX_RS19310	COG3547	Transposase (IS116 IS110 IS902 family)
KOX_RS19315	COG2378	regulation of single-species biofilm formation
KOX_RS19320	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS19330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOX_RS19335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KOX_RS19355	COG0583	DNA-binding transcription factor activity
KOX_RS19385	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS19385	COG2030	dehydratase
KOX_RS19390	COG3396	Phenylacetate-CoA oxygenase
KOX_RS19395	COG3460	Phenylacetate-CoA oxygenase
KOX_RS19400	COG3396	Phenylacetate-CoA oxygenase
KOX_RS19405	COG2151	metal-sulfur cluster biosynthetic enzyme
KOX_RS19410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KOX_RS19415	COG1024	Enoyl-CoA hydratase
KOX_RS19420	COG1024	Enoyl-CoA hydratase
KOX_RS19425	COG1250	3-hydroxyacyl-CoA dehydrogenase
KOX_RS19430	COG2050	protein possibly involved in aromatic compounds catabolism
KOX_RS19435	COG0183	Belongs to the thiolase family
KOX_RS19440	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KOX_RS19445	COG3327	negative regulation of DNA-templated transcription, initiation
KOX_RS19450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KOX_RS19465	COG1643	Atp-dependent helicase
KOX_RS19470	COG4122	O-methyltransferase activity
KOX_RS19475	COG1538	Outer membrane efflux protein
KOX_RS19495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KOX_RS19500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KOX_RS19505	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS19510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KOX_RS19515	COG0456	acetyltransferase
KOX_RS19520	COG0583	DNA-binding transcription factor activity
KOX_RS19525	COG3706	GGDEF domain
KOX_RS19545	COG3038	cytochrome b561
KOX_RS19575	COG0583	DNA-binding transcription factor activity
KOX_RS19580	COG3485	protocatechuate 3,4-dioxygenase
KOX_RS19585	COG3485	protocatechuate 3,4-dioxygenase
KOX_RS19590	COG5383	Protein conserved in bacteria
KOX_RS19595	COG2272	Belongs to the type-B carboxylesterase lipase family
KOX_RS19605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KOX_RS19610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KOX_RS19615	COG1275	C4-dicarboxylate transporter malic acid transport protein
KOX_RS19620	COG0500	methyltransferase
KOX_RS19625	COG2195	Cleaves the N-terminal amino acid of tripeptides
KOX_RS19630	COG0747	negative chemotaxis
KOX_RS19640	COG0697	spore germination
KOX_RS19645	COG2207	Transcriptional regulator
KOX_RS19650	COG3135	benzoate transporter
KOX_RS19655	COG1396	sequence-specific DNA binding
KOX_RS19660	COG0826	peptidase U32
KOX_RS19670	COG1294	oxidase, subunit
KOX_RS19675	COG1271	oxidase subunit
KOX_RS19680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOX_RS19690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KOX_RS19695	COG3842	ATPase activity
KOX_RS19700	COG1176	ABC-type spermidine putrescine transport system, permease component I
KOX_RS19705	COG1177	transmembrane transport
KOX_RS19710	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS19720	COG0596	Alpha beta hydrolase
KOX_RS19725	COG4677	pectinesterase activity
KOX_RS19730	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS19735	COG0747	negative chemotaxis
KOX_RS19745	COG3238	Protein conserved in bacteria
KOX_RS19750	COG1247	-acetyltransferase
KOX_RS19765	COG2130	NADP-dependent
KOX_RS19775	COG3691	Protein conserved in bacteria
KOX_RS19780	COG4772	TonB-dependent receptor
KOX_RS19805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS19810	COG1473	amidohydrolase
KOX_RS19815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS19820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS19835	COG1126	abc transporter atp-binding protein
KOX_RS19845	COG2271	Major facilitator Superfamily
KOX_RS19855	COG1609	Transcriptional regulator
KOX_RS19860	COG0625	glutathione transferase activity
KOX_RS19885	COG2211	Major facilitator Superfamily
KOX_RS19895	COG4977	sequence-specific DNA binding
KOX_RS19900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KOX_RS19905	COG3842	ATPase activity
KOX_RS19910	COG1840	ABC-type Fe3 transport system, periplasmic component
KOX_RS19915	COG1178	ABC-type Fe3 transport system permease component
KOX_RS19920	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KOX_RS19930	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KOX_RS19935	COG1140	nitrate reductase beta subunit
KOX_RS19940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KOX_RS19960	COG0697	spore germination
KOX_RS19970	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS19970	COG0243	molybdopterin cofactor binding
KOX_RS19975	COG0243	molybdopterin cofactor binding
KOX_RS19975	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS19980	COG0437	4 iron, 4 sulfur cluster binding
KOX_RS19985	COG2864	formate dehydrogenase
KOX_RS19995	COG2814	Major facilitator Superfamily
KOX_RS20005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS20015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS20035	COG1064	alcohol dehydrogenase
KOX_RS20050	COG0488	(ABC) transporter
KOX_RS20080	COG1764	response to oxidative stress
KOX_RS20095	COG3781	membrane
KOX_RS20100	COG0243	molybdopterin cofactor binding
KOX_RS20105	COG1280	lysine exporter protein (LysE YggA)
KOX_RS20115	COG0583	DNA-binding transcription factor activity
KOX_RS20120	COG0583	DNA-binding transcription factor activity
KOX_RS20130	COG2271	Major facilitator Superfamily
KOX_RS20170	COG1280	lysine exporter protein (LysE YggA)
KOX_RS20195	COG1116	anion transmembrane transporter activity
KOX_RS20195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KOX_RS20210	COG0439	Biotin carboxylase
KOX_RS20225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KOX_RS20225	COG0519	Catalyzes the synthesis of GMP from XMP
KOX_RS20240	COG0076	glutamate decarboxylase activity
KOX_RS20245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KOX_RS20250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KOX_RS20255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KOX_RS20260	COG1116	anion transmembrane transporter activity
KOX_RS20265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KOX_RS20270	COG0673	inositol 2-dehydrogenase activity
KOX_RS20275	COG1082	Xylose isomerase domain protein TIM barrel
KOX_RS20280	COG1609	Transcriptional regulator
KOX_RS20320	COG1649	PFAM Uncharacterised BCR, COG1649
KOX_RS20325	COG2200	EAL domain
KOX_RS20325	COG2771	luxR family
KOX_RS20330	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KOX_RS20350	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS20360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KOX_RS20375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KOX_RS20380	COG0508	dehydrogenase complex catalyzes the overall conversion of
KOX_RS20385	COG0022	dehydrogenase e1 component
KOX_RS20390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KOX_RS20470	COG1126	abc transporter atp-binding protein
KOX_RS20475	COG0765	amino acid transport
KOX_RS20480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS20490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KOX_RS20510	COG1760	l-serine dehydratase
KOX_RS20515	COG0814	amino acid
KOX_RS20520	COG1169	isochorismate synthase
KOX_RS20525	COG2814	Major facilitator Superfamily
KOX_RS20530	COG1132	(ABC) transporter
KOX_RS20535	COG1132	(ABC) transporter
KOX_RS20535	COG2375	cellular response to nickel ion
KOX_RS20545	COG2226	methyltransferase
KOX_RS20545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOX_RS20545	COG3433	isochorismatase activity
KOX_RS20565	COG1021	2,3-dihydroxybenzoate-AMP ligase
KOX_RS20570	COG4771	TonB-dependent receptor
KOX_RS20575	COG1652	LysM domain
KOX_RS20635	COG1609	Transcriptional regulator
KOX_RS20645	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS20660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOX_RS20670	COG4771	TonB-dependent receptor
KOX_RS20675	COG3391	amine dehydrogenase activity
KOX_RS20705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KOX_RS20750	COG4821	SIS domain
KOX_RS20765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS20805	COG2841	Protein conserved in bacteria
KOX_RS20830	COG0583	DNA-binding transcription factor activity
KOX_RS20835	COG0412	Dienelactone hydrolase
KOX_RS20850	COG0693	protein deglycase activity
KOX_RS20860	COG1609	Transcriptional regulator
KOX_RS20875	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS20900	COG1070	Carbohydrate kinase
KOX_RS20905	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS20910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KOX_RS20915	COG3775	system Galactitol-specific IIC component
KOX_RS20935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS20940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KOX_RS20945	COG1120	ATPase activity
KOX_RS20960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KOX_RS20965	COG1446	asparaginase
KOX_RS20970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KOX_RS20980	COG2207	Transcriptional regulator
KOX_RS20985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KOX_RS21005	COG0765	amino acid transport
KOX_RS21010	COG0765	amino acid transport
KOX_RS21015	COG1126	abc transporter atp-binding protein
KOX_RS21030	COG4628	conserved protein (DUF2132)
KOX_RS21050	COG2011	ABC-type metal ion transport system permease component
KOX_RS21065	COG0477	Major facilitator Superfamily
KOX_RS21100	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOX_RS21105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KOX_RS21150	COG2199	diguanylate cyclase activity
KOX_RS21165	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS21170	COG0583	DNA-binding transcription factor activity
KOX_RS21180	COG0039	L-malate dehydrogenase activity
KOX_RS21220	COG0697	spore germination
KOX_RS21225	COG2814	Major facilitator Superfamily
KOX_RS21260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KOX_RS21300	COG2200	EAL domain
KOX_RS21320	COG2223	nitrite transmembrane transporter activity
KOX_RS21325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KOX_RS21350	COG3122	Protein conserved in bacteria
KOX_RS21380	COG0339	signal peptide processing
KOX_RS21385	COG4221	oxidoreductase activity
KOX_RS21390	COG1802	Transcriptional regulator
KOX_RS21395	COG0589	response to stress
KOX_RS21400	COG0246	Mannitol dehydrogenase
KOX_RS21405	COG0477	Major facilitator Superfamily
KOX_RS21410	COG1063	alcohol dehydrogenase
KOX_RS21415	COG4948	Mandelate Racemase Muconate Lactonizing
KOX_RS21430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KOX_RS21445	COG0243	molybdopterin cofactor binding
KOX_RS21450	COG0437	4 iron, 4 sulfur cluster binding
KOX_RS21455	COG3302	dmso reductase anchor subunit
KOX_RS21460	COG3381	protein complex oligomerization
KOX_RS21470	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KOX_RS21475	COG1940	carbohydrate kinase activity
KOX_RS21480	COG0583	DNA-binding transcription factor activity
KOX_RS21485	COG2814	Major facilitator Superfamily
KOX_RS21490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KOX_RS21500	COG3591	Belongs to the peptidase S1B family
KOX_RS21520	COG0628	permease
KOX_RS21550	COG0679	Auxin Efflux Carrier
KOX_RS21560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KOX_RS21575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KOX_RS21580	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS21590	COG3290	protein histidine kinase activity
KOX_RS21595	COG4565	transcriptional regulatory protein
KOX_RS21615	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS21615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS21620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOX_RS21625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KOX_RS21635	COG0183	Belongs to the thiolase family
KOX_RS21640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KOX_RS21650	COG1414	Transcriptional regulator
KOX_RS21655	COG2840	Smr protein MutS2
KOX_RS21660	COG0583	DNA-binding transcription factor activity
KOX_RS21670	COG1473	amidohydrolase
KOX_RS21675	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KOX_RS21680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KOX_RS21685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KOX_RS21690	COG0589	response to stress
KOX_RS21700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KOX_RS21705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KOX_RS21715	COG0531	amino acid
KOX_RS21725	COG3136	membrane protein required for alginate biosynthesis
KOX_RS21735	COG0745	RESPONSE REGULATOR receiver
KOX_RS21745	COG0386	Belongs to the glutathione peroxidase family
KOX_RS21755	COG2205	protein histidine kinase activity
KOX_RS21765	COG0114	fumarate hydratase activity
KOX_RS21770	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS21770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KOX_RS21775	COG1482	cell wall glycoprotein biosynthetic process
KOX_RS21780	COG5339	Protein conserved in bacteria
KOX_RS21785	COG1609	Transcriptional regulator
KOX_RS21790	COG1263	PTS System
KOX_RS21790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS21795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KOX_RS21805	COG2391	methyltransferase activity
KOX_RS21810	COG0425	Belongs to the sulfur carrier protein TusA family
KOX_RS21825	COG0673	inositol 2-dehydrogenase activity
KOX_RS21835	COG2723	6-phospho-beta-galactosidase activity
KOX_RS21870	COG4659	FMN binding
KOX_RS21880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KOX_RS21890	COG0625	glutathione transferase activity
KOX_RS21910	COG3895	Periplasmic Protein
KOX_RS21925	COG3706	GGDEF domain
KOX_RS21940	COG1566	PFAM secretion protein HlyD family protein
KOX_RS21945	COG1289	transmembrane transporter activity
KOX_RS21955	COG4989	oxidoreductase activity
KOX_RS21960	COG3313	Fe-S protein
KOX_RS21965	COG1309	transcriptional regulator
KOX_RS21970	COG1902	pentaerythritol trinitrate reductase activity
KOX_RS21975	COG0346	lactoylglutathione lyase activity
KOX_RS21985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KOX_RS21990	COG0791	NLP P60 protein
KOX_RS22000	COG2814	Major facilitator Superfamily
KOX_RS22010	COG0583	DNA-binding transcription factor activity
KOX_RS22015	COG2814	Major facilitator Superfamily
KOX_RS22020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KOX_RS22025	COG0307	riboflavin synthase, alpha
KOX_RS22050	COG3729	General stress protein
KOX_RS22055	COG3685	Protein conserved in bacteria
KOX_RS22060	COG3685	Protein conserved in bacteria
KOX_RS22065	COG3546	catalase activity
KOX_RS22070	COG1271	oxidase subunit
KOX_RS22075	COG1294	oxidase, subunit
KOX_RS22090	COG1546	Belongs to the CinA family
KOX_RS22095	COG2323	membrane
KOX_RS22105	COG4529	Protein conserved in bacteria
KOX_RS22110	COG3111	PFAM Bacterial OB fold (BOF) protein
KOX_RS22115	COG1028	Short-chain dehydrogenase reductase Sdr
KOX_RS22120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KOX_RS22135	COG1349	DNA-binding transcription factor activity
KOX_RS22140	COG0346	lactoylglutathione lyase activity
KOX_RS22150	COG4166	transmembrane transport
KOX_RS22165	COG0444	Belongs to the ABC transporter superfamily
KOX_RS22175	COG4993	Dehydrogenase
KOX_RS22180	COG0582	viral genome integration into host DNA
KOX_RS22190	COG3121	Chaperone
KOX_RS22205	COG3539	Fimbrial protein
KOX_RS22210	COG0582	viral genome integration into host DNA
KOX_RS22230	COG1278	Cold shock
KOX_RS22255	COG3842	ATPase activity
KOX_RS22260	COG1175	transmembrane transport
KOX_RS22380	COG1360	Flagellar Motor Protein
KOX_RS22405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KOX_RS22410	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS22415	COG1473	amidohydrolase
KOX_RS22425	COG1126	abc transporter atp-binding protein
KOX_RS22430	COG0765	amino acid transport
KOX_RS22450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS22455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS22460	COG1120	ATPase activity
KOX_RS22465	COG4774	siderophore transport
KOX_RS22470	COG1116	anion transmembrane transporter activity
KOX_RS22475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KOX_RS22490	COG1960	acyl-CoA dehydrogenase activity
KOX_RS22495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS22525	COG2814	Major facilitator Superfamily
KOX_RS22560	COG1414	Transcriptional regulator
KOX_RS22565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KOX_RS22570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOX_RS22575	COG1120	ATPase activity
KOX_RS22585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KOX_RS22590	COG2271	Major facilitator Superfamily
KOX_RS22595	COG1082	Xylose isomerase domain protein TIM barrel
KOX_RS22595	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KOX_RS22620	COG1376	ErfK ybiS ycfS ynhG family protein
KOX_RS22635	COG0719	Fe-S assembly protein
KOX_RS22640	COG0396	ATPase activity
KOX_RS22645	COG0719	Fe-S assembly protein
KOX_RS22650	COG0316	Belongs to the HesB IscA family
KOX_RS22655	COG3539	Fimbrial protein
KOX_RS22670	COG3121	Chaperone
KOX_RS22685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KOX_RS22690	COG2261	transglycosylase associated protein
KOX_RS22695	COG2050	protein possibly involved in aromatic compounds catabolism
KOX_RS22700	COG0277	FAD linked oxidase domain protein
KOX_RS22700	COG0247	lactate metabolic process
KOX_RS22705	COG0628	permease
KOX_RS22710	COG0574	Belongs to the PEP-utilizing enzyme family
KOX_RS22710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KOX_RS22720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KOX_RS22725	COG4256	Hemin uptake protein
KOX_RS22735	COG0791	NLP P60 protein
KOX_RS22745	COG0386	Belongs to the glutathione peroxidase family
KOX_RS22765	COG0072	phenylalanine-tRNA ligase activity
KOX_RS22765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KOX_RS22775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KOX_RS22800	COG3137	Salt-induced outer membrane protein
KOX_RS22805	COG1105	Belongs to the carbohydrate kinase PfkB family
KOX_RS22815	COG3001	Fructosamine kinase
KOX_RS22825	COG2350	Protein conserved in bacteria
KOX_RS22830	COG1902	pentaerythritol trinitrate reductase activity
KOX_RS22850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KOX_RS22860	COG0444	Belongs to the ABC transporter superfamily
KOX_RS22865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS22870	COG0601	transmembrane transport
KOX_RS22880	COG2095	MarC family integral membrane protein
KOX_RS22885	COG1454	alcohol dehydrogenase
KOX_RS22885	COG1012	belongs to the aldehyde dehydrogenase family
KOX_RS22900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KOX_RS22905	COG0745	RESPONSE REGULATOR receiver
KOX_RS22910	COG1752	Esterase of the alpha-beta hydrolase superfamily
KOX_RS22920	COG0788	formyltetrahydrofolate deformylase activity
KOX_RS22935	COG2181	nitrate reductase activity
KOX_RS22940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KOX_RS22945	COG1140	nitrate reductase beta subunit
KOX_RS22950	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KOX_RS22955	COG2223	nitrite transmembrane transporter activity
KOX_RS22960	COG3850	Histidine kinase
KOX_RS22965	COG2197	response regulator
KOX_RS22970	COG4932	domain protein
KOX_RS22975	COG0243	molybdopterin cofactor binding
KOX_RS22980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KOX_RS22980	COG2146	nitrite reductase [NAD(P)H] activity
KOX_RS22985	COG1116	anion transmembrane transporter activity
KOX_RS23000	COG3707	response regulator
KOX_RS23005	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KOX_RS23015	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
KOX_RS23020	COG4572	Cation transport regulator
KOX_RS23025	COG0387	Pfam Sodium calcium exchanger
KOX_RS23045	COG2890	protein-(glutamine-N5) methyltransferase activity
KOX_RS23075	COG0659	secondary active sulfate transmembrane transporter activity
KOX_RS23095	COG0012	GTP binding
KOX_RS23100	COG0582	viral genome integration into host DNA
KOX_RS23110	COG3829	transcription factor binding
KOX_RS23115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KOX_RS23120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KOX_RS23125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOX_RS23135	COG0549	Belongs to the carbamate kinase family
KOX_RS23140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KOX_RS23140	COG3608	succinylglutamate desuccinylase aspartoacylase
KOX_RS23145	COG0493	'glutamate synthase
KOX_RS23145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS23150	COG0402	S-adenosylhomocysteine deaminase activity
KOX_RS23155	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS23160	COG0493	'glutamate synthase
KOX_RS23160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS23165	COG2233	PERMEase
KOX_RS23170	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS23175	COG3383	formate dehydrogenase (NAD+) activity
KOX_RS23180	COG2068	MobA-Related Protein
KOX_RS23195	COG2814	Major facilitator Superfamily
KOX_RS23200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS23200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS23205	COG2351	hydroxyisourate hydrolase activity
KOX_RS23225	COG0583	DNA-binding transcription factor activity
KOX_RS23230	COG0564	pseudouridine synthase activity
KOX_RS23245	COG1174	glycine betaine transport
KOX_RS23255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOX_RS23270	COG2814	Major facilitator Superfamily
KOX_RS23295	COG2308	Evidence 4 Homologs of previously reported genes of
KOX_RS23305	COG1472	Belongs to the glycosyl hydrolase 3 family
KOX_RS23315	COG2211	Major facilitator Superfamily
KOX_RS23330	COG1619	proteins homologs of microcin C7 resistance protein MccF
KOX_RS23350	COG2719	SpoVR family
KOX_RS23380	COG0179	Fumarylacetoacetate (FAA) hydrolase
KOX_RS23395	COG2894	cell division
KOX_RS23405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KOX_RS23415	COG3065	identical protein binding
KOX_RS23420	COG1214	PFAM Peptidase M22, glycoprotease
KOX_RS23425	COG1199	ATP-dependent helicase activity
KOX_RS23430	COG0251	oxidation-reduction process
KOX_RS23440	COG3842	ATPase activity
KOX_RS23445	COG0395	ABC-type sugar transport system, permease component
KOX_RS23450	COG1175	transmembrane transport
KOX_RS23455	COG1653	transport
KOX_RS23485	COG1760	l-serine dehydratase
KOX_RS23490	COG2200	EAL domain
KOX_RS23495	COG1253	flavin adenine dinucleotide binding
KOX_RS23500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS23500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS23505	COG3715	PTS system
KOX_RS23510	COG3716	PTS system mannose fructose sorbose family IID component
KOX_RS23530	COG2226	methyltransferase
KOX_RS23535	COG0768	penicillin binding
KOX_RS23560	COG1414	Transcriptional regulator
KOX_RS23565	COG2814	Major facilitator Superfamily
KOX_RS23585	COG1956	GAF domain-containing protein
KOX_RS23590	COG2995	paraquat-inducible protein a
KOX_RS23595	COG3008	intermembrane lipid transfer
KOX_RS23620	COG2990	Protein conserved in bacteria
KOX_RS23660	COG1276	copper resistance
KOX_RS23665	COG2372	response to copper ion
KOX_RS23675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KOX_RS23680	COG1770	oligopeptidase
KOX_RS23685	COG2979	Protein of unknown function (DUF533)
KOX_RS23690	COG3141	response to X-ray
KOX_RS23700	COG0800	Aldolase
KOX_RS23705	COG0129	dihydroxy-acid dehydratase activity
KOX_RS23710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KOX_RS23715	COG1737	Transcriptional regulator
KOX_RS23725	COG3493	citrate carrier protein
KOX_RS23730	COG0679	Auxin Efflux Carrier
KOX_RS23735	COG0281	malic enzyme
KOX_RS23745	COG1560	Kdo2-lipid A biosynthetic process
KOX_RS23750	COG0739	heme binding
KOX_RS23755	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KOX_RS23765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KOX_RS23785	COG0217	transcriptional regulatory protein
KOX_RS23790	COG0494	nUDIX hydrolase
KOX_RS23800	COG1335	isochorismatase
KOX_RS23805	COG1801	Protein of unknown function DUF72
KOX_RS23810	COG3788	relative of glutathione S-transferase, MAPEG superfamily
KOX_RS23835	COG3102	Protein conserved in bacteria
KOX_RS23845	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KOX_RS23870	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOX_RS23880	COG1879	ABC-type sugar transport system periplasmic component
KOX_RS23890	COG1528	Iron-storage protein
KOX_RS23905	COG0477	Major facilitator Superfamily
KOX_RS23915	COG1528	Iron-storage protein
KOX_RS23925	COG0814	amino acid
KOX_RS23930	COG3012	SEC-C Motif Domain Protein
KOX_RS23930	COG3318	Belongs to the UPF0149 family
KOX_RS23935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KOX_RS23965	COG2197	response regulator
KOX_RS23975	COG2197	response regulator
KOX_RS23980	COG1126	abc transporter atp-binding protein
KOX_RS23985	COG0765	amino acid transport
KOX_RS23995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS24000	COG0366	Alpha amylase catalytic
KOX_RS24035	COG5475	Uncharacterized small protein (DUF2158)
KOX_RS24040	COG2354	Protein conserved in bacteria
KOX_RS24045	COG0697	spore germination
KOX_RS24050	COG3727	T/G mismatch-specific endonuclease activity
KOX_RS24055	COG0270	DNA (cytosine-5-)-methyltransferase activity
KOX_RS24060	COG1418	mRNA catabolic process
KOX_RS24070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KOX_RS24080	COG0463	Glycosyl transferase, family 2
KOX_RS24110	COG0251	oxidation-reduction process
KOX_RS24130	COG2819	hydrolase of the alpha beta superfamily
KOX_RS24140	COG0589	response to stress
KOX_RS24150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOX_RS24180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KOX_RS24210	COG0534	Mate efflux family protein
KOX_RS24220	COG0582	viral genome integration into host DNA
KOX_RS24230	COG2207	Transcriptional regulator
KOX_RS24235	COG2807	transmembrane transport
KOX_RS24250	COG1733	regulation of RNA biosynthetic process
KOX_RS24255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KOX_RS24260	COG2249	NAD(P)H dehydrogenase (quinone) activity
KOX_RS24265	COG0667	Aldo Keto reductase
KOX_RS24310	COG0583	DNA-binding transcription factor activity
KOX_RS24325	COG3321	synthase
KOX_RS24325	COG0604	alcohol dehydrogenase
KOX_RS24330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KOX_RS24375	COG2814	Major facilitator Superfamily
KOX_RS24435	COG3736	Type IV secretory pathway, component VirB8
KOX_RS24440	COG3504	Conjugal transfer protein
KOX_RS24445	COG2948	multi-organism process
KOX_RS24450	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
KOX_RS24480	COG0583	DNA-binding transcription factor activity
KOX_RS24485	COG0604	alcohol dehydrogenase
KOX_RS24490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KOX_RS24530	COG0583	DNA-binding transcription factor activity
KOX_RS24535	COG0667	Aldo Keto reductase
KOX_RS24550	COG1376	ErfK ybiS ycfS ynhG family protein
KOX_RS24590	COG3539	Fimbrial protein
KOX_RS24595	COG3121	Chaperone
KOX_RS24600	COG3188	usher protein
KOX_RS24605	COG3539	Fimbrial protein
KOX_RS24610	COG3539	Fimbrial protein
KOX_RS24615	COG3539	Fimbrial protein
KOX_RS24630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOX_RS24630	COG1263	PTS System
KOX_RS24635	COG2188	Transcriptional regulator
KOX_RS24645	COG3615	Tellurite resistance protein tehB
KOX_RS24650	COG3300	MHYT domain
KOX_RS24650	COG5001	Diguanylate cyclase
KOX_RS24660	COG0477	Major facilitator Superfamily
KOX_RS24665	COG0095	Lipoate-protein ligase
KOX_RS24670	COG0583	DNA-binding transcription factor activity
KOX_RS24675	COG1942	4-Oxalocrotonate Tautomerase
KOX_RS24685	COG1082	Xylose isomerase domain protein TIM barrel
KOX_RS24690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS24690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS24695	COG0673	inositol 2-dehydrogenase activity
KOX_RS24700	COG2814	Major facilitator Superfamily
KOX_RS24710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KOX_RS24730	COG1289	transmembrane transporter activity
KOX_RS24750	COG2925	Exonuclease
KOX_RS24755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KOX_RS24760	COG0640	Transcriptional regulator
KOX_RS24845	COG2205	protein histidine kinase activity
KOX_RS24850	COG3604	Transcriptional regulator
KOX_RS24865	COG0531	amino acid
KOX_RS24870	COG0583	DNA-binding transcription factor activity
KOX_RS24875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KOX_RS24885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KOX_RS24900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KOX_RS24910	COG0107	imidazoleglycerol-phosphate synthase activity
KOX_RS24920	COG1215	transferase activity, transferring glycosyl groups
KOX_RS24970	COG1091	dTDP-4-dehydrorhamnose reductase activity
KOX_RS24980	COG1088	dTDP-glucose 4,6-dehydratase activity
KOX_RS25055	COG1253	flavin adenine dinucleotide binding
KOX_RS25060	COG2982	Protein involved in outer membrane biogenesis
KOX_RS25075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KOX_RS25080	COG0443	Heat shock 70 kDa protein
KOX_RS25085	COG0372	Belongs to the citrate synthase family
KOX_RS25090	COG2205	protein histidine kinase activity
KOX_RS25105	COG1301	dicarboxylic acid transport
KOX_RS25115	COG4608	Belongs to the ABC transporter superfamily
KOX_RS25120	COG0444	Belongs to the ABC transporter superfamily
KOX_RS25125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS25130	COG0601	transmembrane transport
KOX_RS25145	COG2267	carboxylic ester hydrolase activity
KOX_RS25155	COG1522	sequence-specific DNA binding
KOX_RS25170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOX_RS25200	COG2205	protein histidine kinase activity
KOX_RS25205	COG0745	RESPONSE REGULATOR receiver
KOX_RS25210	COG0826	peptidase U32
KOX_RS25230	COG4608	Belongs to the ABC transporter superfamily
KOX_RS25235	COG0444	Belongs to the ABC transporter superfamily
KOX_RS25240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOX_RS25245	COG0601	transmembrane transport
KOX_RS25250	COG0747	negative chemotaxis
KOX_RS25255	COG4948	Mandelate Racemase Muconate Lactonizing
KOX_RS25260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOX_RS25270	COG1070	Carbohydrate kinase
KOX_RS25300	COG1830	Aldolase
KOX_RS25305	COG2211	Major facilitator Superfamily
KOX_RS25310	COG1397	ADP-ribosylglycohydrolase
KOX_RS25315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS25320	COG2188	Transcriptional regulator
KOX_RS25325	COG0351	phosphomethylpyrimidine kinase
KOX_RS25335	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KOX_RS25345	COG0583	DNA-binding transcription factor activity
KOX_RS25355	COG2252	PERMEase
KOX_RS25360	COG0583	DNA-binding transcription factor activity
KOX_RS25365	COG5455	response to cobalt ion
KOX_RS25385	COG4808	Protein conserved in bacteria
KOX_RS25390	COG4807	Protein conserved in bacteria
KOX_RS25400	COG3275	phosphorelay sensor kinase activity
KOX_RS25405	COG0789	Transcriptional regulator
KOX_RS25410	COG1174	glycine betaine transport
KOX_RS25415	COG1125	glycine betaine transport
KOX_RS25420	COG1174	glycine betaine transport
KOX_RS25425	COG1732	Glycine betaine
KOX_RS25430	COG1472	Belongs to the glycosyl hydrolase 3 family
KOX_RS25435	COG0277	FAD linked oxidase domain protein
KOX_RS25445	COG1686	Belongs to the peptidase S11 family
KOX_RS25460	COG0586	Pfam SNARE associated Golgi protein
KOX_RS25465	COG1538	Outer membrane efflux protein
KOX_RS25470	COG2226	methyltransferase
KOX_RS25475	COG2723	6-phospho-beta-galactosidase activity
KOX_RS25490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KOX_RS25495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOX_RS25500	COG0625	glutathione transferase activity
KOX_RS25515	COG2271	Major facilitator Superfamily
KOX_RS25520	COG0583	DNA-binding transcription factor activity
KOX_RS25530	COG1346	cytolysis
KOX_RS25540	COG2949	membrane
KOX_RS25550	COG1129	ABC transporter
KOX_RS25565	COG2311	Membrane
KOX_RS25580	COG4771	TonB-dependent receptor
KOX_RS25585	COG0833	amino acid
KOX_RS25590	COG0583	DNA-binding transcription factor activity
KOX_RS25595	COG2855	membrane
KOX_RS25605	COG1522	sequence-specific DNA binding
KOX_RS25605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS25610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KOX_RS25615	COG2313	pseudouridylate synthase activity
KOX_RS25620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOX_RS25625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS25625	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KOX_RS25625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KOX_RS25630	COG1105	Belongs to the carbohydrate kinase PfkB family
KOX_RS25635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS25635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS25640	COG2814	Major facilitator Superfamily
KOX_RS25650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KOX_RS25655	COG0246	Mannitol dehydrogenase
KOX_RS25660	COG0523	cobalamin synthesis protein
KOX_RS25665	COG0671	phosphoesterase, PA-phosphatase related
KOX_RS25670	COG0791	NLP P60 protein
KOX_RS25675	COG2200	EAL domain
KOX_RS25680	COG4166	transmembrane transport
KOX_RS25685	COG4174	ABC transporter (Permease)
KOX_RS25690	COG4239	(ABC) transporter, permease
KOX_RS25695	COG4172	Belongs to the ABC transporter superfamily
KOX_RS25705	COG2814	Major facilitator Superfamily
KOX_RS25710	COG1187	pseudouridine synthase activity
KOX_RS25715	COG1061	Type III restriction enzyme res subunit
KOX_RS25725	COG0494	nUDIX hydrolase
KOX_RS25730	COG1349	DNA-binding transcription factor activity
KOX_RS25810	COG1388	LysM domain
KOX_RS25810	COG3858	chitin binding
KOX_RS25870	COG0628	permease
KOX_RS25885	COG0659	secondary active sulfate transmembrane transporter activity
KOX_RS25890	COG2239	Acts as a magnesium transporter
KOX_RS25895	COG4615	Cyclic peptide transporter
KOX_RS25900	COG3145	DNA-N1-methyladenine dioxygenase activity
KOX_RS25905	COG2169	Transcriptional regulator
KOX_RS25905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KOX_RS25920	COG0642	Histidine kinase
KOX_RS25920	COG2198	Histidine kinase
KOX_RS25930	COG0784	Response regulator, receiver
KOX_RS25930	COG2205	protein histidine kinase activity
KOX_RS25955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KOX_RS25960	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KOX_RS25965	COG0583	DNA-binding transcription factor activity
KOX_RS25970	COG0584	glycerophosphoryl diester phosphodiesterase
KOX_RS25975	COG2271	Major facilitator Superfamily
KOX_RS25980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KOX_RS25990	COG0247	lactate metabolic process
KOX_RS26000	COG2271	Major facilitator Superfamily
KOX_RS26010	COG1414	Transcriptional regulator
KOX_RS26065	COG3647	Membrane
KOX_RS26095	COG1169	isochorismate synthase
KOX_RS26100	COG2153	protein acetylation
KOX_RS26110	COG0582	viral genome integration into host DNA
KOX_RS26130	COG3121	Chaperone
KOX_RS26140	COG0582	viral genome integration into host DNA
KOX_RS26150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOX_RS26155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KOX_RS26160	COG0713	ATP synthesis coupled electron transport
KOX_RS26165	COG0839	Belongs to the complex I subunit 6 family
KOX_RS26210	COG0583	DNA-binding transcription factor activity
KOX_RS26215	COG0436	Aminotransferase
KOX_RS26225	COG0471	metal ion transport
KOX_RS26225	COG0490	domain, Protein
KOX_RS26230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOX_RS26255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KOX_RS26260	COG3959	Transketolase, thiamine diphosphate binding domain
KOX_RS26265	COG3037	sugar-specific permease SgaT UlaA
KOX_RS26275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOX_RS26280	COG1609	Transcriptional regulator
KOX_RS26290	COG0622	Phosphoesterase
KOX_RS26295	COG0625	glutathione transferase activity
KOX_RS26300	COG0625	glutathione transferase activity
KOX_RS26305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KOX_RS26310	COG1090	epimerase
KOX_RS26330	COG4598	ABC transporter
KOX_RS26335	COG4160	amino acid transport
KOX_RS26355	COG0163	prenyltransferase activity
KOX_RS26360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KOX_RS26365	COG1286	toxin biosynthetic process
KOX_RS26370	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
KOX_RS26375	COG0285	dihydrofolate synthase activity
KOX_RS26385	COG0586	Pfam SNARE associated Golgi protein
KOX_RS26395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KOX_RS26415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOX_RS26430	COG3101	peptidyl-lysine hydroxylation
KOX_RS26435	COG0730	response to heat
KOX_RS26460	COG2062	phosphohistidine phosphatase, SixA
KOX_RS26475	COG3691	Protein conserved in bacteria
KOX_RS26515	COG0583	DNA-binding transcription factor activity
KOX_RS26520	COG2807	transmembrane transport
KOX_RS26525	COG0436	Aminotransferase
KOX_RS26530	COG3275	phosphorelay sensor kinase activity
KOX_RS26535	COG3279	Response regulator of the LytR AlgR family
KOX_RS26550	COG3961	Belongs to the TPP enzyme family
KOX_RS26555	COG0667	Aldo Keto reductase
KOX_RS26570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KOX_RS26575	COG2200	EAL domain
KOX_RS26575	COG2199	diguanylate cyclase activity
KOX_RS26590	COG3415	Transposase
KOX_RS26595	COG3415	Transposase
KOX_RS26625	COG0583	DNA-binding transcription factor activity
KOX_RS26630	COG2211	Major facilitator Superfamily
KOX_RS26635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KOX_RS26640	COG0583	DNA-binding transcription factor activity
KOX_RS26645	COG0385	Bile acid
KOX_RS26650	COG3530	Putative quorum-sensing-regulated virulence factor
KOX_RS26670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KOX_RS26715	COG4319	ketosteroid isomerase
KOX_RS26725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KOX_RS26730	COG4208	sulfate ABC transporter
KOX_RS26735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KOX_RS26740	COG4150	thiosulfate binding
KOX_RS26745	COG2837	iron assimilation
KOX_RS26765	COG0860	N-Acetylmuramoyl-L-alanine amidase
KOX_RS26775	COG2207	Transcriptional regulator
KOX_RS26845	COG4766	ethanolamine catabolic process
KOX_RS26855	COG4810	utilization protein
KOX_RS26865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KOX_RS26870	COG5342	invasion associated locus B
KOX_RS26880	COG0493	'glutamate synthase
KOX_RS26880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS26885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KOX_RS26890	COG1393	Belongs to the ArsC family
KOX_RS26905	COG0400	carboxylic ester hydrolase activity
KOX_RS26915	COG2321	neutral zinc metallopeptidase
KOX_RS26925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KOX_RS26935	COG2716	regulation of RNA biosynthetic process
KOX_RS26940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KOX_RS26945	COG0628	permease
KOX_RS26950	COG4783	chaperone-mediated protein folding
KOX_RS26955	COG1393	Belongs to the ArsC family
KOX_RS26965	COG2233	PERMEase
KOX_RS26970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KOX_RS26975	COG2723	6-phospho-beta-galactosidase activity
KOX_RS26990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KOX_RS27000	COG2211	Major facilitator Superfamily
KOX_RS27020	COG0248	Ppx GppA phosphatase
KOX_RS27025	COG2200	EAL domain
KOX_RS27035	COG0583	DNA-binding transcription factor activity
KOX_RS27045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KOX_RS27045	COG0519	Catalyzes the synthesis of GMP from XMP
KOX_RS27050	COG0516	GMP reductase activity
KOX_RS27050	COG0517	IMP dehydrogenase activity
KOX_RS27055	COG1570	exodeoxyribonuclease VII activity
KOX_RS27070	COG1645	bacterial-type flagellum-dependent swarming motility
KOX_RS27095	COG2976	Protein conserved in bacteria
KOX_RS27125	COG4953	penicillin-binding protein 1C
KOX_RS27130	COG2373	Large extracellular alpha-helical protein
KOX_RS27140	COG1473	amidohydrolase
KOX_RS27145	COG2897	thiosulfate sulfurtransferase activity
KOX_RS27160	COG2975	iron-sulfur cluster assembly
KOX_RS27165	COG0633	Ferredoxin
KOX_RS27185	COG0822	iron-sulfur transferase activity
KOX_RS27215	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
KOX_RS27220	COG3683	transport system, periplasmic component
KOX_RS27225	COG3711	transcriptional antiterminator
KOX_RS27230	COG2814	Major facilitator Superfamily
KOX_RS27235	COG2017	converts alpha-aldose to the beta-anomer
KOX_RS27240	COG0477	Major facilitator Superfamily
KOX_RS27240	COG2814	Major facilitator Superfamily
KOX_RS27245	COG0457	Tetratricopeptide repeat
KOX_RS27250	COG1940	carbohydrate kinase activity
KOX_RS27255	COG2259	Doxx family
KOX_RS27265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KOX_RS27265	COG1017	nitric oxide dioxygenase activity
KOX_RS27270	COG1609	Transcriptional regulator
KOX_RS27290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KOX_RS27295	COG0371	Dehydrogenase
KOX_RS27300	COG0347	Belongs to the P(II) protein family
KOX_RS27305	COG2204	response regulator
KOX_RS27310	COG3170	Tfp pilus assembly protein FimV
KOX_RS27315	COG2205	protein histidine kinase activity
KOX_RS27320	COG0047	phosphoribosylformylglycinamidine synthase activity
KOX_RS27320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KOX_RS27335	COG0560	Phosphoserine phosphatase
KOX_RS27340	COG1737	Transcriptional regulator
KOX_RS27345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KOX_RS27355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KOX_RS27375	COG0681	Belongs to the peptidase S26 family
KOX_RS27385	COG3086	response to oxidative stress
KOX_RS27395	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
KOX_RS27405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KOX_RS27430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOX_RS27435	COG3118	belongs to the thioredoxin family
KOX_RS27440	COG3148	PFAM DTW domain containing protein
KOX_RS27450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KOX_RS27455	COG5544	Lipoprotein
KOX_RS27460	COG0477	Major facilitator Superfamily
KOX_RS27505	COG1203	CRISPR-associated helicase, Cas3