locus-tag	class	description
HVX57_RS00010	COG0592	DNA-directed DNA polymerase activity
HVX57_RS00020	COG0187	DNA topoisomerase II activity
HVX57_RS00025	COG0583	DNA-binding transcription factor activity
HVX57_RS00035	COG0561	phosphatase activity
HVX57_RS00040	COG2186	Transcriptional regulator
HVX57_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HVX57_RS00050	COG0800	Aldolase
HVX57_RS00060	COG2271	Major facilitator Superfamily
HVX57_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HVX57_RS00070	COG5645	(Lipo)protein
HVX57_RS00090	COG2188	Transcriptional regulator
HVX57_RS00105	COG2149	membrane
HVX57_RS00115	COG0641	radical SAM
HVX57_RS00125	COG2610	gluconate transmembrane transporter activity
HVX57_RS00130	COG0583	DNA-binding transcription factor activity
HVX57_RS00140	COG2814	Major facilitator Superfamily
HVX57_RS00165	COG0028	Belongs to the TPP enzyme family
HVX57_RS00170	COG0440	acetolactate synthase activity
HVX57_RS00175	COG2197	response regulator
HVX57_RS00225	COG2188	Transcriptional regulator
HVX57_RS00250	COG4580	involved in the transport of maltose and maltodextrins
HVX57_RS00255	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX57_RS00260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS00260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS00270	COG1609	Transcriptional regulator
HVX57_RS00280	COG5464	transposase or invertase
HVX57_RS00285	COG0697	spore germination
HVX57_RS00300	COG1263	PTS System
HVX57_RS00300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS00310	COG2814	Major facilitator Superfamily
HVX57_RS00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX57_RS00325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS00335	COG1309	transcriptional regulator
HVX57_RS00345	COG0583	DNA-binding transcription factor activity
HVX57_RS00360	COG1464	Belongs to the NlpA lipoprotein family
HVX57_RS00375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVX57_RS00385	COG1064	alcohol dehydrogenase
HVX57_RS00405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HVX57_RS00440	COG2211	Major facilitator Superfamily
HVX57_RS00445	COG1501	Belongs to the glycosyl hydrolase 31 family
HVX57_RS00450	COG3711	transcriptional antiterminator
HVX57_RS00455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS00455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS00455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS00460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS00465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS00465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS00475	COG0191	fructose-bisphosphate aldolase activity
HVX57_RS00480	COG1940	carbohydrate kinase activity
HVX57_RS00495	COG1486	melibiose metabolic process
HVX57_RS00500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS00500	COG1263	PTS System
HVX57_RS00505	COG2982	Protein involved in outer membrane biogenesis
HVX57_RS00510	COG2233	PERMEase
HVX57_RS00515	COG0786	glutamate:sodium symporter activity
HVX57_RS00530	COG3074	FtsZ-dependent cytokinesis
HVX57_RS00560	COG3152	Membrane
HVX57_RS00570	COG1494	fructose-1,6-bisphosphatase
HVX57_RS00575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVX57_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX57_RS00585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX57_RS00605	COG2860	membrane
HVX57_RS00615	COG1561	YicC-like family, N-terminal region
HVX57_RS00625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HVX57_RS00640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVX57_RS00650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HVX57_RS00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HVX57_RS00675	COG1519	Transferase
HVX57_RS00680	COG1216	Glycosyl transferase, family 2
HVX57_RS00685	COG0438	transferase activity, transferring glycosyl groups
HVX57_RS00695	COG0859	PFAM glycosyl transferase family 9
HVX57_RS00720	COG0859	PFAM glycosyl transferase family 9
HVX57_RS00725	COG0859	PFAM glycosyl transferase family 9
HVX57_RS00735	COG0156	8-amino-7-oxononanoate synthase activity
HVX57_RS00745	COG0463	Glycosyl transferase, family 2
HVX57_RS00750	COG2861	carbohydrate metabolic process
HVX57_RS00755	COG4942	peptidase
HVX57_RS00765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX57_RS00770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX57_RS00790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVX57_RS00800	COG2186	Transcriptional regulator
HVX57_RS00820	COG3722	fumarate hydratase activity
HVX57_RS00840	COG1566	PFAM secretion protein HlyD family protein
HVX57_RS00845	COG0625	glutathione transferase activity
HVX57_RS00855	COG3276	selenocysteine insertion sequence binding
HVX57_RS00865	COG2211	Major facilitator Superfamily
HVX57_RS00870	COG1917	Cupin 2, conserved barrel domain protein
HVX57_RS00870	COG4977	sequence-specific DNA binding
HVX57_RS00875	COG0235	Class ii aldolase
HVX57_RS00880	COG3623	hexulose-6-phosphate isomerase
HVX57_RS00885	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVX57_RS00890	COG1070	Carbohydrate kinase
HVX57_RS00905	COG2731	YhcH YjgK YiaL family protein
HVX57_RS00915	COG1414	Transcriptional regulator
HVX57_RS00920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX57_RS00925	COG3977	Valine--pyruvate aminotransferase
HVX57_RS00930	COG0366	Alpha amylase catalytic
HVX57_RS00935	COG2992	FlgJ-related protein
HVX57_RS00940	COG1609	Transcriptional regulator
HVX57_RS00940	COG2207	Transcriptional regulator
HVX57_RS00945	COG4214	carbohydrate transport
HVX57_RS00955	COG4213	ABC transporter substrate-binding protein
HVX57_RS00960	COG2115	Belongs to the xylose isomerase family
HVX57_RS00965	COG1070	Carbohydrate kinase
HVX57_RS00970	COG4682	membrane
HVX57_RS00975	COG4682	membrane
HVX57_RS00980	COG3274	enterobacterial common antigen metabolic process
HVX57_RS01010	COG1278	Cold shock
HVX57_RS01015	COG2944	sequence-specific DNA binding
HVX57_RS01020	COG2814	Major facilitator Superfamily
HVX57_RS01040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS01050	COG1609	Transcriptional regulator
HVX57_RS01055	COG2885	chlorophyll binding
HVX57_RS01060	COG0243	molybdopterin cofactor binding
HVX57_RS01065	COG0456	acetyltransferase
HVX57_RS01070	COG2818	Glycosylase
HVX57_RS01075	COG5571	outer membrane autotransporter
HVX57_RS01080	COG2223	nitrite transmembrane transporter activity
HVX57_RS01095	COG0747	negative chemotaxis
HVX57_RS01100	COG0601	transmembrane transport
HVX57_RS01105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX57_RS01110	COG0444	Belongs to the ABC transporter superfamily
HVX57_RS01115	COG4608	Belongs to the ABC transporter superfamily
HVX57_RS01125	COG0489	protein tyrosine kinase activity
HVX57_RS01140	COG0457	Tetratricopeptide repeat
HVX57_RS01165	COG2194	sulfuric ester hydrolase activity
HVX57_RS01200	COG1215	transferase activity, transferring glycosyl groups
HVX57_RS01205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVX57_RS01210	COG3118	belongs to the thioredoxin family
HVX57_RS01210	COG0457	Tetratricopeptide repeat
HVX57_RS01215	COG2199	diguanylate cyclase activity
HVX57_RS01215	COG2200	EAL domain
HVX57_RS01225	COG0612	Peptidase, M16
HVX57_RS01235	COG2982	Protein involved in outer membrane biogenesis
HVX57_RS01240	COG0477	Major facilitator Superfamily
HVX57_RS01245	COG1295	ribonuclease BN
HVX57_RS01250	COG0583	DNA-binding transcription factor activity
HVX57_RS01255	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS01260	COG2197	response regulator
HVX57_RS01280	COG1454	alcohol dehydrogenase
HVX57_RS01285	COG0625	glutathione transferase activity
HVX57_RS01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX57_RS01295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVX57_RS01300	COG0671	phosphoesterase, PA-phosphatase related
HVX57_RS01305	COG2205	protein histidine kinase activity
HVX57_RS01310	COG0745	RESPONSE REGULATOR receiver
HVX57_RS01315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX57_RS01320	COG2183	response to ionizing radiation
HVX57_RS01325	COG1918	ferrous iron import across plasma membrane
HVX57_RS01360	COG2610	gluconate transmembrane transporter activity
HVX57_RS01385	COG0589	response to stress
HVX57_RS01395	COG0306	phosphate transporter
HVX57_RS01400	COG2081	HI0933 family
HVX57_RS01405	COG2204	response regulator
HVX57_RS01410	COG3964	amidohydrolase
HVX57_RS01415	COG0471	metal ion transport
HVX57_RS01420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HVX57_RS01425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVX57_RS01435	COG2239	Acts as a magnesium transporter
HVX57_RS01455	COG0444	Belongs to the ABC transporter superfamily
HVX57_RS01460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX57_RS01465	COG0601	transmembrane transport
HVX57_RS01470	COG0747	negative chemotaxis
HVX57_RS01480	COG3479	Phenolic acid decarboxylase
HVX57_RS01520	COG0628	permease
HVX57_RS01525	COG0477	Major facilitator Superfamily
HVX57_RS01535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVX57_RS01550	COG3714	YhhN family
HVX57_RS01560	COG3776	membrane
HVX57_RS01565	COG0742	ribosomal rna small subunit methyltransferase
HVX57_RS01570	COG0552	protein localization to endoplasmic reticulum
HVX57_RS01575	COG2884	Cell division ATP-binding protein ftsE
HVX57_RS01580	COG2177	Part of the ABC transporter FtsEX involved in
HVX57_RS01595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVX57_RS01605	COG0683	leucine binding
HVX57_RS01615	COG0683	leucine binding
HVX57_RS01640	COG2721	sulfolactate sulfo-lyase activity
HVX57_RS01650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVX57_RS01655	COG1414	Transcriptional regulator
HVX57_RS01680	COG0584	glycerophosphoryl diester phosphodiesterase
HVX57_RS01690	COG0405	Gamma-glutamyltransferase
HVX57_RS01695	COG1247	-acetyltransferase
HVX57_RS01705	COG0673	inositol 2-dehydrogenase activity
HVX57_RS01710	COG1741	Belongs to the pirin family
HVX57_RS01715	COG1609	Transcriptional regulator
HVX57_RS01720	COG3265	gluconokinase activity
HVX57_RS01725	COG2610	gluconate transmembrane transporter activity
HVX57_RS01730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX57_RS01755	COG0058	SHG alpha-glucan phosphorylase activity
HVX57_RS01760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX57_RS01775	COG1349	DNA-binding transcription factor activity
HVX57_RS01785	COG0058	SHG alpha-glucan phosphorylase activity
HVX57_RS01790	COG1640	4-alpha-glucanotransferase
HVX57_RS01805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVX57_RS01810	COG1011	Hydrolase
HVX57_RS01820	COG0494	nUDIX hydrolase
HVX57_RS01825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVX57_RS01850	COG4796	Type ii and iii secretion system protein
HVX57_RS01865	COG3266	domain, Protein
HVX57_RS01870	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVX57_RS01875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX57_RS01900	COG2146	nitrite reductase [NAD(P)H] activity
HVX57_RS01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVX57_RS01910	COG0402	S-adenosylhomocysteine deaminase activity
HVX57_RS01915	COG0738	Major facilitator superfamily
HVX57_RS01940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVX57_RS01945	COG1289	transmembrane transporter activity
HVX57_RS01955	COG1765	OsmC-like protein
HVX57_RS01960	COG3954	Phosphoribulokinase
HVX57_RS01970	COG0429	hydrolase of the alpha beta-hydrolase fold
HVX57_RS01980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVX57_RS01990	COG0488	(ABC) transporter
HVX57_RS02005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVX57_RS02010	COG1047	Peptidyl-prolyl cis-trans
HVX57_RS02020	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX57_RS02025	COG2964	Protein conserved in bacteria
HVX57_RS02080	COG0051	transcription antitermination factor activity, RNA binding
HVX57_RS02090	COG0088	Forms part of the polypeptide exit tunnel
HVX57_RS02105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HVX57_RS02120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HVX57_RS02170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HVX57_RS02185	COG0201	protein transport
HVX57_RS02200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HVX57_RS02210	COG0202	RNA polymerase activity
HVX57_RS02215	COG0203	ribosomal protein L17
HVX57_RS02225	COG0789	Transcriptional regulator
HVX57_RS02230	COG3036	rescue of stalled ribosome
HVX57_RS02260	COG0758	DNA mediated transformation
HVX57_RS02270	COG0551	DNA topoisomerase type I activity
HVX57_RS02290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX57_RS02330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX57_RS02335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS02340	COG1309	transcriptional regulator
HVX57_RS02365	COG4145	pantothenate transmembrane transporter activity
HVX57_RS02370	COG3924	membrane
HVX57_RS02375	COG0439	Biotin carboxylase
HVX57_RS02380	COG0511	ligase activity, forming carbon-carbon bonds
HVX57_RS02395	COG0604	alcohol dehydrogenase
HVX57_RS02400	COG2199	diguanylate cyclase activity
HVX57_RS02400	COG2200	EAL domain
HVX57_RS02405	COG1077	Cell shape determining protein MreB Mrl
HVX57_RS02410	COG1792	Involved in formation and maintenance of cell shape
HVX57_RS02415	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVX57_RS02425	COG1530	ribonuclease E activity
HVX57_RS02430	COG3164	Protein of unknown function
HVX57_RS02435	COG0312	modulator of DNA gyrase
HVX57_RS02440	COG1349	DNA-binding transcription factor activity
HVX57_RS02445	COG0583	DNA-binding transcription factor activity
HVX57_RS02460	COG1289	transmembrane transporter activity
HVX57_RS02465	COG2732	(Barnase) inhibitor
HVX57_RS02490	COG2188	Transcriptional regulator
HVX57_RS02500	COG0471	metal ion transport
HVX57_RS02505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS02510	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS02535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX57_RS02540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX57_RS02545	COG3105	Protein conserved in bacteria
HVX57_RS02550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVX57_RS02565	COG0625	glutathione transferase activity
HVX57_RS02570	COG2969	positive regulation of protein catabolic process
HVX57_RS02575	COG3539	Fimbrial protein
HVX57_RS02580	COG3121	Chaperone
HVX57_RS02585	COG3188	usher protein
HVX57_RS02595	COG3539	Fimbrial protein
HVX57_RS02600	COG0493	'glutamate synthase
HVX57_RS02605	COG0070	glutamate synthase
HVX57_RS02605	COG0069	glutamate synthase activity
HVX57_RS02605	COG0067	glutamate synthase
HVX57_RS02610	COG1242	4 iron, 4 sulfur cluster binding
HVX57_RS02615	COG2198	Histidine kinase
HVX57_RS02615	COG5002	protein histidine kinase activity
HVX57_RS02615	COG0784	Response regulator, receiver
HVX57_RS02620	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVX57_RS02625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVX57_RS02630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS02635	COG1660	Displays ATPase and GTPase activities
HVX57_RS02640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS02645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX57_RS02650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVX57_RS02655	COG1137	ATPase activity
HVX57_RS02660	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVX57_RS02665	COG3117	lipopolysaccharide transmembrane transporter activity
HVX57_RS02670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVX57_RS02680	COG0530	calcium, potassium:sodium antiporter activity
HVX57_RS02685	COG1127	ABC transporter
HVX57_RS02690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVX57_RS02695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX57_RS02700	COG2854	intermembrane phospholipid transfer
HVX57_RS02705	COG3113	response to antibiotic
HVX57_RS02710	COG5007	Belongs to the BolA IbaG family
HVX57_RS02720	COG3423	Transcriptional regulator
HVX57_RS02725	COG0142	geranyltranstransferase activity
HVX57_RS02740	COG0697	spore germination
HVX57_RS02750	COG2027	D-alanyl-D-alanine carboxypeptidase
HVX57_RS02760	COG1534	Rna-binding protein
HVX57_RS02770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVX57_RS02775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVX57_RS02785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX57_RS02825	COG0195	Participates in both transcription termination and antitermination
HVX57_RS02830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HVX57_RS02865	COG0513	Belongs to the DEAD box helicase family
HVX57_RS02870	COG0814	amino acid
HVX57_RS02875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX57_RS02880	COG0826	peptidase U32
HVX57_RS02885	COG0826	peptidase U32
HVX57_RS02890	COG3154	lipid carrier protein
HVX57_RS02895	COG3153	acetyltransferase
HVX57_RS02900	COG2827	Endonuclease containing a URI domain
HVX57_RS02910	COG0693	protein deglycase activity
HVX57_RS02915	COG0702	epimerase
HVX57_RS02920	COG0701	Predicted permease
HVX57_RS02925	COG2823	Periplasmic or secreted lipoprotein
HVX57_RS02945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVX57_RS02960	COG1063	alcohol dehydrogenase
HVX57_RS02965	COG3775	system Galactitol-specific IIC component
HVX57_RS02970	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX57_RS02975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS02980	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HVX57_RS02985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS02985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS02990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS02990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS02990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS03005	COG1349	DNA-binding transcription factor activity
HVX57_RS03010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS03015	COG2721	sulfolactate sulfo-lyase activity
HVX57_RS03020	COG2271	Major facilitator Superfamily
HVX57_RS03030	COG2084	Dehydrogenase
HVX57_RS03035	COG1929	Belongs to the glycerate kinase type-1 family
HVX57_RS03070	COG1741	Belongs to the pirin family
HVX57_RS03075	COG0583	DNA-binding transcription factor activity
HVX57_RS03080	COG3152	Membrane
HVX57_RS03085	COG0435	Glutathione S-transferase
HVX57_RS03090	COG2259	Doxx family
HVX57_RS03100	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVX57_RS03105	COG4575	ribosome binding
HVX57_RS03110	COG1422	Protein of unknown function (DUF1090)
HVX57_RS03120	COG0586	Pfam SNARE associated Golgi protein
HVX57_RS03125	COG2186	Transcriptional regulator
HVX57_RS03130	COG2271	Major facilitator Superfamily
HVX57_RS03140	COG2721	sulfolactate sulfo-lyase activity
HVX57_RS03160	COG0673	inositol 2-dehydrogenase activity
HVX57_RS03165	COG1451	nucleotide metabolic process
HVX57_RS03170	COG3507	Belongs to the glycosyl hydrolase 43 family
HVX57_RS03180	COG2211	Major facilitator Superfamily
HVX57_RS03190	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVX57_RS03190	COG1902	pentaerythritol trinitrate reductase activity
HVX57_RS03255	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVX57_RS03255	COG3408	Glycogen debranching enzyme
HVX57_RS03265	COG0531	amino acid
HVX57_RS03270	COG0531	amino acid
HVX57_RS03275	COG2731	YhcH YjgK YiaL family protein
HVX57_RS03280	COG3250	beta-galactosidase activity
HVX57_RS03285	COG1609	Transcriptional regulator
HVX57_RS03290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVX57_RS03300	COG1695	Transcriptional regulator
HVX57_RS03305	COG2375	cellular response to nickel ion
HVX57_RS03320	COG1461	Dihydroxyacetone kinase
HVX57_RS03325	COG2376	Dihydroxyacetone kinase
HVX57_RS03365	COG0358	DNA primase activity
HVX57_RS03370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVX57_RS03425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX57_RS03440	COG4991	sh3 domain protein
HVX57_RS03445	COG3025	triphosphatase activity
HVX57_RS03465	COG2960	long-chain fatty acid transporting porin activity
HVX57_RS03475	COG3539	Fimbrial protein
HVX57_RS03480	COG3121	Chaperone
HVX57_RS03485	COG3188	usher protein
HVX57_RS03490	COG3539	Fimbrial protein
HVX57_RS03500	COG3384	dioxygenase
HVX57_RS03505	COG0754	glutathionylspermidine amidase activity
HVX57_RS03520	COG0494	nUDIX hydrolase
HVX57_RS03525	COG3151	Protein conserved in bacteria
HVX57_RS03530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVX57_RS03535	COG3150	esterase
HVX57_RS03545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVX57_RS03550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVX57_RS03555	COG0642	Histidine kinase
HVX57_RS03560	COG0745	RESPONSE REGULATOR receiver
HVX57_RS03565	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX57_RS03570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVX57_RS03580	COG0204	Acyl-transferase
HVX57_RS03585	COG2132	Multicopper oxidase
HVX57_RS03590	COG1032	radical SAM domain protein
HVX57_RS03605	COG1979	alcohol dehydrogenase
HVX57_RS03610	COG2207	Transcriptional regulator
HVX57_RS03615	COG0586	Pfam SNARE associated Golgi protein
HVX57_RS03630	COG0848	biopolymer transport protein
HVX57_RS03635	COG2211	Major facilitator Superfamily
HVX57_RS03655	COG0625	glutathione transferase activity
HVX57_RS03665	COG0754	glutathionylspermidine amidase activity
HVX57_RS03670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX57_RS03680	COG2365	Tyrosine phosphatase family
HVX57_RS03700	COG0626	cystathionine gamma-synthase activity
HVX57_RS03710	COG0471	metal ion transport
HVX57_RS03745	COG1811	Na channel or pump
HVX57_RS03750	COG1982	Orn Lys Arg decarboxylase major
HVX57_RS03755	COG2211	Major facilitator Superfamily
HVX57_RS03770	COG1194	a g-specific adenine glycosylase
HVX57_RS03780	COG3171	Protein conserved in bacteria
HVX57_RS03795	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX57_RS03800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX57_RS03805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX57_RS03820	COG0762	integral membrane protein
HVX57_RS03825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVX57_RS03830	COG2805	Type II/IV secretion system protein
HVX57_RS03835	COG2197	response regulator
HVX57_RS03850	COG0189	ligase activity
HVX57_RS03855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVX57_RS03860	COG2356	endonuclease I
HVX57_RS03870	COG2814	Major facilitator Superfamily
HVX57_RS03895	COG1166	arginine decarboxylase activity
HVX57_RS03910	COG2146	nitrite reductase [NAD(P)H] activity
HVX57_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS03930	COG1414	Transcriptional regulator
HVX57_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS03965	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HVX57_RS03980	COG0501	Belongs to the peptidase M48B family
HVX57_RS03985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX57_RS03990	COG1122	ATPase activity
HVX57_RS04025	COG0191	fructose-bisphosphate aldolase activity
HVX57_RS04030	COG0668	transmembrane transport
HVX57_RS04040	COG2968	Membrane
HVX57_RS04045	COG0583	DNA-binding transcription factor activity
HVX57_RS04050	COG0427	acetyl-CoA hydrolase
HVX57_RS04055	COG1024	Enoyl-CoA hydratase
HVX57_RS04060	COG1703	isobutyryl-CoA mutase activity
HVX57_RS04065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX57_RS04065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX57_RS04080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVX57_RS04085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVX57_RS04105	COG0006	proline dipeptidase activity
HVX57_RS04110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX57_RS04115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX57_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS04140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVX57_RS04145	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS04150	COG1737	Transcriptional regulator
HVX57_RS04160	COG1272	protein, Hemolysin III
HVX57_RS04175	COG3716	PTS system mannose fructose sorbose family IID component
HVX57_RS04180	COG3715	PTS system
HVX57_RS04185	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS04185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS04205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVX57_RS04215	COG0716	FMN binding
HVX57_RS04230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVX57_RS04245	COG3385	transposase activity
HVX57_RS04255	COG4942	peptidase
HVX57_RS04265	COG0745	RESPONSE REGULATOR receiver
HVX57_RS04290	COG2771	luxR family
HVX57_RS04325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX57_RS04335	COG0529	Catalyzes the synthesis of activated sulfate
HVX57_RS04335	COG2046	Belongs to the sulfate adenylyltransferase family
HVX57_RS04345	COG3835	regulator
HVX57_RS04350	COG1929	Belongs to the glycerate kinase type-1 family
HVX57_RS04395	COG0738	Major facilitator superfamily
HVX57_RS04400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS04405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX57_RS04410	COG1349	DNA-binding transcription factor activity
HVX57_RS04425	COG1349	DNA-binding transcription factor activity
HVX57_RS04440	COG3104	oligopeptide transport
HVX57_RS04455	COG1538	Outer membrane efflux protein
HVX57_RS04460	COG1289	transmembrane transporter activity
HVX57_RS04475	COG3592	Divergent 4Fe-4S mono-cluster
HVX57_RS04480	COG2388	GCN5-related N-acetyl-transferase
HVX57_RS04490	COG3539	Fimbrial protein
HVX57_RS04495	COG3539	Fimbrial protein
HVX57_RS04500	COG3539	Fimbrial protein
HVX57_RS04505	COG3188	usher protein
HVX57_RS04510	COG3121	Chaperone
HVX57_RS04515	COG3539	Fimbrial protein
HVX57_RS04525	COG4974	Belongs to the 'phage' integrase family
HVX57_RS04530	COG0582	viral genome integration into host DNA
HVX57_RS04540	COG1522	sequence-specific DNA binding
HVX57_RS04550	COG1846	Transcriptional regulator
HVX57_RS04555	COG0697	spore germination
HVX57_RS04570	COG0640	Transcriptional regulator
HVX57_RS04615	COG0667	Aldo Keto reductase
HVX57_RS04620	COG0814	amino acid
HVX57_RS04635	COG0183	Belongs to the thiolase family
HVX57_RS04645	COG0823	Involved in the tonB-independent uptake of proteins
HVX57_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS04655	COG2814	Major facilitator Superfamily
HVX57_RS04680	COG0823	Involved in the tonB-independent uptake of proteins
HVX57_RS04690	COG3842	ATPase activity
HVX57_RS04695	COG0395	ABC-type sugar transport system, permease component
HVX57_RS04700	COG1175	transmembrane transport
HVX57_RS04710	COG1794	racemase activity, acting on amino acids and derivatives
HVX57_RS04715	COG0583	DNA-binding transcription factor activity
HVX57_RS04725	COG1609	Transcriptional regulator
HVX57_RS04730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS04735	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS04740	COG2186	Transcriptional regulator
HVX57_RS04750	COG1609	Transcriptional regulator
HVX57_RS04765	COG0667	Aldo Keto reductase
HVX57_RS04775	COG0861	Integral membrane protein TerC family
HVX57_RS04805	COG2165	general secretion pathway protein
HVX57_RS04810	COG4795	General secretion pathway protein
HVX57_RS04820	COG4967	type IV pilus modification protein PilV
HVX57_RS04825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVX57_RS04830	COG1025	Belongs to the peptidase M16 family
HVX57_RS04835	COG1074	ATP-dependent DNA helicase activity
HVX57_RS04840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVX57_RS04845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVX57_RS04845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVX57_RS04850	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX57_RS04855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HVX57_RS04885	COG4656	Part of a membrane complex involved in electron transport
HVX57_RS04890	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS04890	COG1454	alcohol dehydrogenase
HVX57_RS04920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVX57_RS05085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVX57_RS05090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVX57_RS05095	COG2166	iron-sulfur cluster assembly
HVX57_RS05100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVX57_RS05110	COG0583	DNA-binding transcription factor activity
HVX57_RS05115	COG2363	Small membrane protein
HVX57_RS05125	COG1349	DNA-binding transcription factor activity
HVX57_RS05145	COG0738	Major facilitator superfamily
HVX57_RS05150	COG0235	Class ii aldolase
HVX57_RS05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX57_RS05180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX57_RS05185	COG1760	l-serine dehydratase
HVX57_RS05190	COG0814	amino acid
HVX57_RS05195	COG1611	Belongs to the LOG family
HVX57_RS05210	COG3098	single-species biofilm formation
HVX57_RS05215	COG0564	pseudouridine synthase activity
HVX57_RS05220	COG0716	FMN binding
HVX57_RS05225	COG2271	Major facilitator Superfamily
HVX57_RS05230	COG4948	Mandelate Racemase Muconate Lactonizing
HVX57_RS05235	COG4948	Mandelate Racemase Muconate Lactonizing
HVX57_RS05240	COG1929	Belongs to the glycerate kinase type-1 family
HVX57_RS05245	COG3850	Histidine kinase
HVX57_RS05245	COG3437	response regulator, receiver
HVX57_RS05245	COG2205	protein histidine kinase activity
HVX57_RS05245	COG4999	Histidine kinase
HVX57_RS05255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX57_RS05260	COG3956	TIGRFAM MazG family protein
HVX57_RS05280	COG0602	queuosine metabolic process
HVX57_RS05285	COG0720	synthase
HVX57_RS05315	COG2234	aminopeptidase activity
HVX57_RS05375	COG1388	LysM domain
HVX57_RS05375	COG4942	peptidase
HVX57_RS05380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX57_RS05390	COG0477	Major facilitator Superfamily
HVX57_RS05410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVX57_RS05430	COG3539	Fimbrial protein
HVX57_RS05440	COG3188	usher protein
HVX57_RS05445	COG3121	Chaperone
HVX57_RS05455	COG3539	Fimbrial protein
HVX57_RS05485	COG1132	(ABC) transporter
HVX57_RS05490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS05500	COG1538	Outer membrane efflux protein
HVX57_RS05505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX57_RS05545	COG1454	alcohol dehydrogenase
HVX57_RS05555	COG1063	alcohol dehydrogenase
HVX57_RS05560	COG2271	Major facilitator Superfamily
HVX57_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS05575	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HVX57_RS05580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS05585	COG4558	Periplasmic binding protein
HVX57_RS05590	COG3720	iron ion transport
HVX57_RS05610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVX57_RS05615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVX57_RS05620	COG1121	(ABC) transporter
HVX57_RS05630	COG1609	Transcriptional regulator
HVX57_RS05635	COG1940	carbohydrate kinase activity
HVX57_RS05640	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX57_RS05645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS05650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS05655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS05670	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS05675	COG0657	acetylesterase activity
HVX57_RS05675	COG2755	lipolytic protein G-D-S-L family
HVX57_RS05685	COG0309	Hydrogenase expression formation protein (HypE)
HVX57_RS05690	COG0409	Hydrogenase expression formation protein
HVX57_RS05695	COG0298	carbon dioxide binding
HVX57_RS05700	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVX57_RS05715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX57_RS05720	COG0651	ATP synthesis coupled electron transport
HVX57_RS05725	COG0650	Formate hydrogenlyase subunit 4
HVX57_RS05730	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVX57_RS05730	COG3261	NADH dehydrogenase
HVX57_RS05735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX57_RS05740	COG3260	NADH ubiquinone oxidoreductase 20
HVX57_RS05750	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX57_RS05755	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS05760	COG1263	PTS System
HVX57_RS05760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS05765	COG1609	Transcriptional regulator
HVX57_RS05770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX57_RS05775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVX57_RS05780	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HVX57_RS05805	COG1349	DNA-binding transcription factor activity
HVX57_RS05810	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS05825	COG3732	PTS system glucitol sorbitol-specific
HVX57_RS05830	COG3730	PTS system glucitol sorbitol-specific
HVX57_RS05835	COG2951	lytic endotransglycosylase activity
HVX57_RS05845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVX57_RS05850	COG0803	Belongs to the bacterial solute-binding protein 9 family
HVX57_RS05860	COG1546	Belongs to the CinA family
HVX57_RS05880	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVX57_RS05910	COG2823	Periplasmic or secreted lipoprotein
HVX57_RS05915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX57_RS05920	COG1238	metal cluster binding
HVX57_RS05940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVX57_RS05945	COG2814	Major facilitator Superfamily
HVX57_RS05950	COG1566	PFAM secretion protein HlyD family protein
HVX57_RS05955	COG1846	Transcriptional regulator
HVX57_RS05965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVX57_RS05970	COG2113	Glycine betaine
HVX57_RS05975	COG4176	ABC-type proline glycine betaine transport system permease component
HVX57_RS05985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX57_RS05990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX57_RS06000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX57_RS06005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX57_RS06015	COG4575	ribosome binding
HVX57_RS06040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX57_RS06045	COG0640	Transcriptional regulator
HVX57_RS06050	COG0671	phosphoesterase, PA-phosphatase related
HVX57_RS06055	COG3284	Transcriptional regulator
HVX57_RS06060	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS06075	COG3188	usher protein
HVX57_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS06105	COG2814	Major facilitator Superfamily
HVX57_RS06110	COG1858	cytochrome C peroxidase
HVX57_RS06120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX57_RS06125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX57_RS06130	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX57_RS06140	COG1138	Cytochrome C-type biogenesis protein
HVX57_RS06145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVX57_RS06150	COG4235	cytochrome complex assembly
HVX57_RS06150	COG3088	subunit of a heme lyase
HVX57_RS06160	COG0235	Class ii aldolase
HVX57_RS06165	COG1126	abc transporter atp-binding protein
HVX57_RS06170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS06225	COG0582	viral genome integration into host DNA
HVX57_RS06240	COG2867	negative regulation of translational initiation
HVX57_RS06255	COG0497	DNA recombination
HVX57_RS06270	COG4536	flavin adenine dinucleotide binding
HVX57_RS06275	COG4137	Cytochrome C assembly protein
HVX57_RS06280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVX57_RS06315	COG2885	chlorophyll binding
HVX57_RS06320	COG2199	diguanylate cyclase activity
HVX57_RS06330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX57_RS06335	COG0287	Prephenate dehydrogenase
HVX57_RS06335	COG1605	Chorismate mutase
HVX57_RS06345	COG1605	Chorismate mutase
HVX57_RS06345	COG0077	Prephenate dehydratase
HVX57_RS06355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX57_RS06360	COG3385	transposase activity
HVX57_RS06365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX57_RS06380	COG0542	response to heat
HVX57_RS06410	COG0477	Major facilitator Superfamily
HVX57_RS06420	COG5544	Lipoprotein
HVX57_RS06425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX57_RS06440	COG3118	belongs to the thioredoxin family
HVX57_RS06445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX57_RS06460	COG0513	Belongs to the DEAD box helicase family
HVX57_RS06470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVX57_RS06480	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVX57_RS06490	COG3086	response to oxidative stress
HVX57_RS06500	COG0681	Belongs to the peptidase S26 family
HVX57_RS06520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVX57_RS06530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX57_RS06535	COG1737	Transcriptional regulator
HVX57_RS06540	COG0560	Phosphoserine phosphatase
HVX57_RS06555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVX57_RS06555	COG0047	phosphoribosylformylglycinamidine synthase activity
HVX57_RS06560	COG2205	protein histidine kinase activity
HVX57_RS06565	COG3170	Tfp pilus assembly protein FimV
HVX57_RS06570	COG2204	response regulator
HVX57_RS06575	COG0347	Belongs to the P(II) protein family
HVX57_RS06580	COG1017	nitric oxide dioxygenase activity
HVX57_RS06580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX57_RS06590	COG2259	Doxx family
HVX57_RS06595	COG1940	carbohydrate kinase activity
HVX57_RS06600	COG0457	Tetratricopeptide repeat
HVX57_RS06605	COG0477	Major facilitator Superfamily
HVX57_RS06605	COG2814	Major facilitator Superfamily
HVX57_RS06610	COG2017	converts alpha-aldose to the beta-anomer
HVX57_RS06615	COG2814	Major facilitator Superfamily
HVX57_RS06620	COG3711	transcriptional antiterminator
HVX57_RS06625	COG3683	transport system, periplasmic component
HVX57_RS06630	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HVX57_RS06655	COG0822	iron-sulfur transferase activity
HVX57_RS06675	COG0633	Ferredoxin
HVX57_RS06680	COG2975	iron-sulfur cluster assembly
HVX57_RS06695	COG2897	thiosulfate sulfurtransferase activity
HVX57_RS06700	COG1473	amidohydrolase
HVX57_RS06710	COG2373	Large extracellular alpha-helical protein
HVX57_RS06715	COG4953	penicillin-binding protein 1C
HVX57_RS06745	COG2976	Protein conserved in bacteria
HVX57_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVX57_RS06855	COG1645	bacterial-type flagellum-dependent swarming motility
HVX57_RS06870	COG1570	exodeoxyribonuclease VII activity
HVX57_RS06875	COG0517	IMP dehydrogenase activity
HVX57_RS06875	COG0516	GMP reductase activity
HVX57_RS06880	COG0519	Catalyzes the synthesis of GMP from XMP
HVX57_RS06880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HVX57_RS06890	COG0583	DNA-binding transcription factor activity
HVX57_RS06900	COG2200	EAL domain
HVX57_RS06905	COG0248	Ppx GppA phosphatase
HVX57_RS06925	COG2211	Major facilitator Superfamily
HVX57_RS06935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVX57_RS06950	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS06955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HVX57_RS06960	COG2233	PERMEase
HVX57_RS06970	COG1393	Belongs to the ArsC family
HVX57_RS06975	COG4783	chaperone-mediated protein folding
HVX57_RS06980	COG0628	permease
HVX57_RS06985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVX57_RS06990	COG2716	regulation of RNA biosynthetic process
HVX57_RS07000	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVX57_RS07010	COG2321	neutral zinc metallopeptidase
HVX57_RS07020	COG0400	carboxylic ester hydrolase activity
HVX57_RS07040	COG1393	Belongs to the ArsC family
HVX57_RS07050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX57_RS07055	COG0493	'glutamate synthase
HVX57_RS07055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX57_RS07065	COG5342	invasion associated locus B
HVX57_RS07070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX57_RS07080	COG4810	utilization protein
HVX57_RS07090	COG4766	ethanolamine catabolic process
HVX57_RS07160	COG2207	Transcriptional regulator
HVX57_RS07170	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX57_RS07190	COG2837	iron assimilation
HVX57_RS07235	COG4150	thiosulfate binding
HVX57_RS07240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVX57_RS07245	COG4208	sulfate ABC transporter
HVX57_RS07250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVX57_RS07260	COG4319	ketosteroid isomerase
HVX57_RS07320	COG3530	Putative quorum-sensing-regulated virulence factor
HVX57_RS07325	COG0385	Bile acid
HVX57_RS07330	COG0583	DNA-binding transcription factor activity
HVX57_RS07335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVX57_RS07340	COG2211	Major facilitator Superfamily
HVX57_RS07345	COG0583	DNA-binding transcription factor activity
HVX57_RS07375	COG3415	Transposase
HVX57_RS07380	COG3415	Transposase
HVX57_RS07395	COG2199	diguanylate cyclase activity
HVX57_RS07395	COG2200	EAL domain
HVX57_RS07400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX57_RS07415	COG0667	Aldo Keto reductase
HVX57_RS07420	COG3961	Belongs to the TPP enzyme family
HVX57_RS07435	COG3279	Response regulator of the LytR AlgR family
HVX57_RS07440	COG3275	phosphorelay sensor kinase activity
HVX57_RS07445	COG0436	Aminotransferase
HVX57_RS07455	COG2807	transmembrane transport
HVX57_RS07460	COG0583	DNA-binding transcription factor activity
HVX57_RS07485	COG2116	formate transmembrane transporter activity
HVX57_RS07500	COG3691	Protein conserved in bacteria
HVX57_RS07515	COG2062	phosphohistidine phosphatase, SixA
HVX57_RS07540	COG0730	response to heat
HVX57_RS07545	COG3101	peptidyl-lysine hydroxylation
HVX57_RS07560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX57_RS07580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX57_RS07590	COG0586	Pfam SNARE associated Golgi protein
HVX57_RS07600	COG0285	dihydrofolate synthase activity
HVX57_RS07605	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVX57_RS07610	COG1286	toxin biosynthetic process
HVX57_RS07615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVX57_RS07620	COG0163	prenyltransferase activity
HVX57_RS07640	COG4160	amino acid transport
HVX57_RS07645	COG4598	ABC transporter
HVX57_RS07665	COG1090	epimerase
HVX57_RS07670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX57_RS07675	COG0625	glutathione transferase activity
HVX57_RS07680	COG0625	glutathione transferase activity
HVX57_RS07685	COG0622	Phosphoesterase
HVX57_RS07695	COG1609	Transcriptional regulator
HVX57_RS07700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS07710	COG3037	sugar-specific permease SgaT UlaA
HVX57_RS07715	COG3959	Transketolase, thiamine diphosphate binding domain
HVX57_RS07720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVX57_RS07745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX57_RS07750	COG0471	metal ion transport
HVX57_RS07750	COG0490	domain, Protein
HVX57_RS07760	COG0436	Aminotransferase
HVX57_RS07765	COG0583	DNA-binding transcription factor activity
HVX57_RS07810	COG0839	Belongs to the complex I subunit 6 family
HVX57_RS07815	COG0713	ATP synthesis coupled electron transport
HVX57_RS07820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVX57_RS07825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX57_RS07835	COG0582	viral genome integration into host DNA
HVX57_RS07845	COG3121	Chaperone
HVX57_RS07865	COG0582	viral genome integration into host DNA
HVX57_RS07875	COG2153	protein acetylation
HVX57_RS07880	COG1169	isochorismate synthase
HVX57_RS07935	COG0642	Histidine kinase
HVX57_RS07965	COG1414	Transcriptional regulator
HVX57_RS07975	COG2271	Major facilitator Superfamily
HVX57_RS07985	COG0247	lactate metabolic process
HVX57_RS07995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX57_RS08000	COG2271	Major facilitator Superfamily
HVX57_RS08005	COG0584	glycerophosphoryl diester phosphodiesterase
HVX57_RS08010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX57_RS08035	COG2205	protein histidine kinase activity
HVX57_RS08035	COG0784	Response regulator, receiver
HVX57_RS08045	COG2198	Histidine kinase
HVX57_RS08045	COG0642	Histidine kinase
HVX57_RS08060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX57_RS08060	COG2169	Transcriptional regulator
HVX57_RS08070	COG4615	Cyclic peptide transporter
HVX57_RS08075	COG2239	Acts as a magnesium transporter
HVX57_RS08080	COG0659	secondary active sulfate transmembrane transporter activity
HVX57_RS08095	COG0628	permease
HVX57_RS08120	COG1349	DNA-binding transcription factor activity
HVX57_RS08125	COG0494	nUDIX hydrolase
HVX57_RS08135	COG1061	Type III restriction enzyme res subunit
HVX57_RS08140	COG1187	pseudouridine synthase activity
HVX57_RS08145	COG2814	Major facilitator Superfamily
HVX57_RS08155	COG4172	Belongs to the ABC transporter superfamily
HVX57_RS08160	COG4239	(ABC) transporter, permease
HVX57_RS08165	COG4174	ABC transporter (Permease)
HVX57_RS08170	COG4166	transmembrane transport
HVX57_RS08175	COG2200	EAL domain
HVX57_RS08180	COG0791	NLP P60 protein
HVX57_RS08185	COG0671	phosphoesterase, PA-phosphatase related
HVX57_RS08190	COG0523	cobalamin synthesis protein
HVX57_RS08195	COG0246	Mannitol dehydrogenase
HVX57_RS08200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HVX57_RS08210	COG2814	Major facilitator Superfamily
HVX57_RS08215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS08215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS08220	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX57_RS08225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVX57_RS08225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS08225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS08230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS08235	COG2313	pseudouridylate synthase activity
HVX57_RS08240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX57_RS08245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS08245	COG1522	sequence-specific DNA binding
HVX57_RS08255	COG2855	membrane
HVX57_RS08260	COG0583	DNA-binding transcription factor activity
HVX57_RS08265	COG0833	amino acid
HVX57_RS08270	COG4771	TonB-dependent receptor
HVX57_RS08290	COG2311	Membrane
HVX57_RS08305	COG1129	ABC transporter
HVX57_RS08335	COG2949	membrane
HVX57_RS08345	COG1346	cytolysis
HVX57_RS08355	COG0583	DNA-binding transcription factor activity
HVX57_RS08360	COG2271	Major facilitator Superfamily
HVX57_RS08375	COG0625	glutathione transferase activity
HVX57_RS08380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX57_RS08385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX57_RS08400	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS08405	COG2226	methyltransferase
HVX57_RS08410	COG1538	Outer membrane efflux protein
HVX57_RS08415	COG0586	Pfam SNARE associated Golgi protein
HVX57_RS08425	COG1686	Belongs to the peptidase S11 family
HVX57_RS08435	COG0277	FAD linked oxidase domain protein
HVX57_RS08440	COG1472	Belongs to the glycosyl hydrolase 3 family
HVX57_RS08445	COG1732	Glycine betaine
HVX57_RS08450	COG1174	glycine betaine transport
HVX57_RS08455	COG1125	glycine betaine transport
HVX57_RS08460	COG1174	glycine betaine transport
HVX57_RS08470	COG0789	Transcriptional regulator
HVX57_RS08475	COG3275	phosphorelay sensor kinase activity
HVX57_RS08485	COG4807	Protein conserved in bacteria
HVX57_RS08490	COG4808	Protein conserved in bacteria
HVX57_RS08510	COG5455	response to cobalt ion
HVX57_RS08515	COG0583	DNA-binding transcription factor activity
HVX57_RS08520	COG2252	PERMEase
HVX57_RS08530	COG0583	DNA-binding transcription factor activity
HVX57_RS08540	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVX57_RS08550	COG0351	phosphomethylpyrimidine kinase
HVX57_RS08555	COG2188	Transcriptional regulator
HVX57_RS08560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS08565	COG1397	ADP-ribosylglycohydrolase
HVX57_RS08570	COG2211	Major facilitator Superfamily
HVX57_RS08575	COG1830	Aldolase
HVX57_RS08605	COG1070	Carbohydrate kinase
HVX57_RS08615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX57_RS08620	COG4948	Mandelate Racemase Muconate Lactonizing
HVX57_RS08625	COG0747	negative chemotaxis
HVX57_RS08630	COG0601	transmembrane transport
HVX57_RS08640	COG0444	Belongs to the ABC transporter superfamily
HVX57_RS08645	COG4608	Belongs to the ABC transporter superfamily
HVX57_RS08670	COG0745	RESPONSE REGULATOR receiver
HVX57_RS08675	COG2205	protein histidine kinase activity
HVX57_RS08705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS08720	COG1522	sequence-specific DNA binding
HVX57_RS08730	COG1301	dicarboxylic acid transport
HVX57_RS08750	COG2205	protein histidine kinase activity
HVX57_RS08755	COG0372	Belongs to the citrate synthase family
HVX57_RS08760	COG0443	Heat shock 70 kDa protein
HVX57_RS08765	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVX57_RS08780	COG2982	Protein involved in outer membrane biogenesis
HVX57_RS08785	COG1253	flavin adenine dinucleotide binding
HVX57_RS08830	COG1088	dTDP-glucose 4,6-dehydratase activity
HVX57_RS08880	COG2244	polysaccharide biosynthetic process
HVX57_RS08890	COG1216	Glycosyl transferase, family 2
HVX57_RS08945	COG1215	transferase activity, transferring glycosyl groups
HVX57_RS08955	COG0107	imidazoleglycerol-phosphate synthase activity
HVX57_RS08965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVX57_RS08980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVX57_RS08995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX57_RS09000	COG0583	DNA-binding transcription factor activity
HVX57_RS09010	COG0531	amino acid
HVX57_RS09025	COG3604	Transcriptional regulator
HVX57_RS09030	COG2205	protein histidine kinase activity
HVX57_RS09115	COG0640	Transcriptional regulator
HVX57_RS09120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HVX57_RS09125	COG2925	Exonuclease
HVX57_RS09145	COG1289	transmembrane transporter activity
HVX57_RS09165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HVX57_RS09175	COG1942	4-Oxalocrotonate Tautomerase
HVX57_RS09180	COG0583	DNA-binding transcription factor activity
HVX57_RS09185	COG0095	Lipoate-protein ligase
HVX57_RS09190	COG0477	Major facilitator Superfamily
HVX57_RS09200	COG5001	Diguanylate cyclase
HVX57_RS09200	COG3300	MHYT domain
HVX57_RS09205	COG3615	Tellurite resistance protein tehB
HVX57_RS09215	COG2188	Transcriptional regulator
HVX57_RS09220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS09220	COG1263	PTS System
HVX57_RS09235	COG3539	Fimbrial protein
HVX57_RS09240	COG3539	Fimbrial protein
HVX57_RS09245	COG3539	Fimbrial protein
HVX57_RS09250	COG3188	usher protein
HVX57_RS09255	COG3121	Chaperone
HVX57_RS09260	COG3539	Fimbrial protein
HVX57_RS09305	COG2197	response regulator
HVX57_RS09310	COG3321	synthase
HVX57_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS09310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVX57_RS09310	COG0318	PFAM AMP-dependent synthetase and ligase
HVX57_RS09310	COG0300	oxidoreductase activity
HVX57_RS09320	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVX57_RS09330	COG1960	acyl-CoA dehydrogenase activity
HVX57_RS09335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVX57_RS09340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVX57_RS09355	COG2226	methyltransferase
HVX57_RS09355	COG3433	isochorismatase activity
HVX57_RS09355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVX57_RS09360	COG0154	amidase activity
HVX57_RS09440	COG0629	single-stranded DNA binding
HVX57_RS09485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX57_RS09620	COG2003	Belongs to the UPF0758 family
HVX57_RS09640	COG0582	viral genome integration into host DNA
HVX57_RS09660	COG1376	ErfK ybiS ycfS ynhG family protein
HVX57_RS09675	COG0667	Aldo Keto reductase
HVX57_RS09680	COG0583	DNA-binding transcription factor activity
HVX57_RS09725	COG0534	Mate efflux family protein
HVX57_RS09735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVX57_RS09765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX57_RS09775	COG0589	response to stress
HVX57_RS09785	COG2819	hydrolase of the alpha beta superfamily
HVX57_RS09805	COG0251	oxidation-reduction process
HVX57_RS09835	COG0463	Glycosyl transferase, family 2
HVX57_RS09845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX57_RS09855	COG1418	mRNA catabolic process
HVX57_RS09860	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVX57_RS09865	COG3727	T/G mismatch-specific endonuclease activity
HVX57_RS09870	COG0697	spore germination
HVX57_RS09875	COG2354	Protein conserved in bacteria
HVX57_RS09880	COG5475	Uncharacterized small protein (DUF2158)
HVX57_RS09910	COG0366	Alpha amylase catalytic
HVX57_RS09935	COG2197	response regulator
HVX57_RS09945	COG2197	response regulator
HVX57_RS09975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVX57_RS09980	COG3012	SEC-C Motif Domain Protein
HVX57_RS09980	COG3318	Belongs to the UPF0149 family
HVX57_RS09985	COG0814	amino acid
HVX57_RS09995	COG1528	Iron-storage protein
HVX57_RS10005	COG0477	Major facilitator Superfamily
HVX57_RS10025	COG1528	Iron-storage protein
HVX57_RS10035	COG1879	ABC-type sugar transport system periplasmic component
HVX57_RS10045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS10075	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HVX57_RS10085	COG3102	Protein conserved in bacteria
HVX57_RS10105	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVX57_RS10115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVX57_RS10190	COG0582	viral genome integration into host DNA
HVX57_RS10240	COG4712	double-strand break repair protein
HVX57_RS10300	COG3756	Protein conserved in bacteria
HVX57_RS10590	COG1335	isochorismatase
HVX57_RS10600	COG0494	nUDIX hydrolase
HVX57_RS10605	COG0217	transcriptional regulatory protein
HVX57_RS10625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVX57_RS10635	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVX57_RS10640	COG0739	heme binding
HVX57_RS10645	COG1560	Kdo2-lipid A biosynthetic process
HVX57_RS10655	COG1737	Transcriptional regulator
HVX57_RS10660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVX57_RS10665	COG0129	dihydroxy-acid dehydratase activity
HVX57_RS10670	COG0800	Aldolase
HVX57_RS10680	COG3141	response to X-ray
HVX57_RS10685	COG2979	Protein of unknown function (DUF533)
HVX57_RS10690	COG1770	oligopeptidase
HVX57_RS10695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX57_RS10705	COG2372	response to copper ion
HVX57_RS10710	COG1276	copper resistance
HVX57_RS10750	COG2990	Protein conserved in bacteria
HVX57_RS10775	COG3008	intermembrane lipid transfer
HVX57_RS10780	COG2995	paraquat-inducible protein a
HVX57_RS10785	COG1956	GAF domain-containing protein
HVX57_RS10805	COG2814	Major facilitator Superfamily
HVX57_RS10810	COG1414	Transcriptional regulator
HVX57_RS10840	COG0768	penicillin binding
HVX57_RS10845	COG2226	methyltransferase
HVX57_RS10860	COG3716	PTS system mannose fructose sorbose family IID component
HVX57_RS10865	COG3715	PTS system
HVX57_RS10870	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS10870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS10875	COG1253	flavin adenine dinucleotide binding
HVX57_RS10880	COG2200	EAL domain
HVX57_RS10885	COG1760	l-serine dehydratase
HVX57_RS10915	COG1653	transport
HVX57_RS10920	COG1175	transmembrane transport
HVX57_RS10925	COG0395	ABC-type sugar transport system, permease component
HVX57_RS10930	COG3842	ATPase activity
HVX57_RS10940	COG3547	Transposase (IS116 IS110 IS902 family)
HVX57_RS10945	COG0251	oxidation-reduction process
HVX57_RS10950	COG1199	ATP-dependent helicase activity
HVX57_RS10955	COG1214	PFAM Peptidase M22, glycoprotease
HVX57_RS10960	COG3065	identical protein binding
HVX57_RS10970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVX57_RS10980	COG2894	cell division
HVX57_RS10995	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVX57_RS11025	COG2719	SpoVR family
HVX57_RS11045	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVX57_RS11060	COG2211	Major facilitator Superfamily
HVX57_RS11070	COG1472	Belongs to the glycosyl hydrolase 3 family
HVX57_RS11080	COG2308	Evidence 4 Homologs of previously reported genes of
HVX57_RS11105	COG2814	Major facilitator Superfamily
HVX57_RS11120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX57_RS11130	COG1174	glycine betaine transport
HVX57_RS11145	COG0564	pseudouridine synthase activity
HVX57_RS11150	COG0583	DNA-binding transcription factor activity
HVX57_RS11170	COG2351	hydroxyisourate hydrolase activity
HVX57_RS11175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS11175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS11180	COG2814	Major facilitator Superfamily
HVX57_RS11205	COG2233	PERMEase
HVX57_RS11215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX57_RS11220	COG0402	S-adenosylhomocysteine deaminase activity
HVX57_RS11225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX57_RS11225	COG0493	'glutamate synthase
HVX57_RS11230	COG3608	succinylglutamate desuccinylase aspartoacylase
HVX57_RS11230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVX57_RS11235	COG0549	Belongs to the carbamate kinase family
HVX57_RS11245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX57_RS11250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX57_RS11255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVX57_RS11280	COG0012	GTP binding
HVX57_RS11300	COG0659	secondary active sulfate transmembrane transporter activity
HVX57_RS11330	COG2890	protein-(glutamine-N5) methyltransferase activity
HVX57_RS11350	COG0387	Pfam Sodium calcium exchanger
HVX57_RS11355	COG4572	Cation transport regulator
HVX57_RS11360	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVX57_RS11370	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVX57_RS11375	COG3707	response regulator
HVX57_RS11380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX57_RS11390	COG1116	anion transmembrane transporter activity
HVX57_RS11395	COG2146	nitrite reductase [NAD(P)H] activity
HVX57_RS11395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVX57_RS11400	COG0243	molybdopterin cofactor binding
HVX57_RS11405	COG4932	domain protein
HVX57_RS11410	COG2197	response regulator
HVX57_RS11415	COG3850	Histidine kinase
HVX57_RS11420	COG2223	nitrite transmembrane transporter activity
HVX57_RS11425	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVX57_RS11430	COG1140	nitrate reductase beta subunit
HVX57_RS11435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVX57_RS11440	COG2181	nitrate reductase activity
HVX57_RS11460	COG0788	formyltetrahydrofolate deformylase activity
HVX57_RS11470	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVX57_RS11475	COG0745	RESPONSE REGULATOR receiver
HVX57_RS11480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVX57_RS11495	COG1454	alcohol dehydrogenase
HVX57_RS11495	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS11500	COG2095	MarC family integral membrane protein
HVX57_RS11510	COG0601	transmembrane transport
HVX57_RS11515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX57_RS11520	COG0444	Belongs to the ABC transporter superfamily
HVX57_RS11530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX57_RS11550	COG1902	pentaerythritol trinitrate reductase activity
HVX57_RS11555	COG2350	Protein conserved in bacteria
HVX57_RS11560	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HVX57_RS11565	COG3001	Fructosamine kinase
HVX57_RS11575	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX57_RS11580	COG3137	Salt-induced outer membrane protein
HVX57_RS11610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HVX57_RS11625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVX57_RS11625	COG0072	phenylalanine-tRNA ligase activity
HVX57_RS11645	COG0386	Belongs to the glutathione peroxidase family
HVX57_RS11655	COG0791	NLP P60 protein
HVX57_RS11665	COG4256	Hemin uptake protein
HVX57_RS11670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX57_RS11680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX57_RS11680	COG0574	Belongs to the PEP-utilizing enzyme family
HVX57_RS11690	COG0628	permease
HVX57_RS11695	COG0277	FAD linked oxidase domain protein
HVX57_RS11695	COG0247	lactate metabolic process
HVX57_RS11700	COG2050	protein possibly involved in aromatic compounds catabolism
HVX57_RS11705	COG2261	transglycosylase associated protein
HVX57_RS11710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX57_RS11720	COG3539	Fimbrial protein
HVX57_RS11725	COG3121	Chaperone
HVX57_RS11740	COG3539	Fimbrial protein
HVX57_RS11745	COG0316	Belongs to the HesB IscA family
HVX57_RS11750	COG0719	Fe-S assembly protein
HVX57_RS11755	COG0396	ATPase activity
HVX57_RS11760	COG0719	Fe-S assembly protein
HVX57_RS11775	COG1376	ErfK ybiS ycfS ynhG family protein
HVX57_RS11805	COG2271	Major facilitator Superfamily
HVX57_RS11810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVX57_RS11835	COG1414	Transcriptional regulator
HVX57_RS11870	COG2814	Major facilitator Superfamily
HVX57_RS11900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX57_RS11905	COG1960	acyl-CoA dehydrogenase activity
HVX57_RS11920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX57_RS11925	COG1116	anion transmembrane transporter activity
HVX57_RS11930	COG4774	siderophore transport
HVX57_RS11935	COG1120	ATPase activity
HVX57_RS11940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS11945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS11965	COG0765	amino acid transport
HVX57_RS11970	COG1126	abc transporter atp-binding protein
HVX57_RS11985	COG3383	formate dehydrogenase (NAD+) activity
HVX57_RS11990	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX57_RS12015	COG2885	chlorophyll binding
HVX57_RS12145	COG1175	transmembrane transport
HVX57_RS12150	COG3842	ATPase activity
HVX57_RS12175	COG1278	Cold shock
HVX57_RS12180	COG0626	cystathionine gamma-synthase activity
HVX57_RS12185	COG1757	Na H antiporter
HVX57_RS12205	COG0582	viral genome integration into host DNA
HVX57_RS12210	COG3539	Fimbrial protein
HVX57_RS12235	COG0582	viral genome integration into host DNA
HVX57_RS12240	COG4993	Dehydrogenase
HVX57_RS12250	COG0444	Belongs to the ABC transporter superfamily
HVX57_RS12265	COG4166	transmembrane transport
HVX57_RS12275	COG0346	lactoylglutathione lyase activity
HVX57_RS12280	COG1349	DNA-binding transcription factor activity
HVX57_RS12295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVX57_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS12305	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX57_RS12315	COG4529	Protein conserved in bacteria
HVX57_RS12330	COG0366	Alpha amylase catalytic
HVX57_RS12335	COG1609	Transcriptional regulator
HVX57_RS12345	COG2323	membrane
HVX57_RS12350	COG1546	Belongs to the CinA family
HVX57_RS12365	COG1294	oxidase, subunit
HVX57_RS12370	COG1271	oxidase subunit
HVX57_RS12375	COG3546	catalase activity
HVX57_RS12380	COG3685	Protein conserved in bacteria
HVX57_RS12385	COG3685	Protein conserved in bacteria
HVX57_RS12390	COG3729	General stress protein
HVX57_RS12415	COG0307	riboflavin synthase, alpha
HVX57_RS12420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVX57_RS12425	COG2814	Major facilitator Superfamily
HVX57_RS12430	COG0583	DNA-binding transcription factor activity
HVX57_RS12445	COG2814	Major facilitator Superfamily
HVX57_RS12455	COG0791	NLP P60 protein
HVX57_RS12460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVX57_RS12470	COG0346	lactoylglutathione lyase activity
HVX57_RS12475	COG1902	pentaerythritol trinitrate reductase activity
HVX57_RS12480	COG1309	transcriptional regulator
HVX57_RS12485	COG3313	Fe-S protein
HVX57_RS12490	COG4989	oxidoreductase activity
HVX57_RS12500	COG1289	transmembrane transporter activity
HVX57_RS12505	COG1566	PFAM secretion protein HlyD family protein
HVX57_RS12520	COG3706	GGDEF domain
HVX57_RS12535	COG3895	Periplasmic Protein
HVX57_RS12555	COG0625	glutathione transferase activity
HVX57_RS12565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVX57_RS12575	COG4659	FMN binding
HVX57_RS12610	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS12620	COG0673	inositol 2-dehydrogenase activity
HVX57_RS12635	COG0425	Belongs to the sulfur carrier protein TusA family
HVX57_RS12640	COG2391	methyltransferase activity
HVX57_RS12650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVX57_RS12655	COG1263	PTS System
HVX57_RS12655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS12660	COG1609	Transcriptional regulator
HVX57_RS12665	COG5339	Protein conserved in bacteria
HVX57_RS12670	COG1482	cell wall glycoprotein biosynthetic process
HVX57_RS12675	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS12675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS12680	COG0114	fumarate hydratase activity
HVX57_RS12690	COG2205	protein histidine kinase activity
HVX57_RS12700	COG0386	Belongs to the glutathione peroxidase family
HVX57_RS12710	COG0745	RESPONSE REGULATOR receiver
HVX57_RS12720	COG3136	membrane protein required for alginate biosynthesis
HVX57_RS12730	COG0531	amino acid
HVX57_RS12745	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVX57_RS12750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVX57_RS12760	COG0589	response to stress
HVX57_RS12765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX57_RS12770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX57_RS12775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HVX57_RS12780	COG1473	amidohydrolase
HVX57_RS12790	COG0583	DNA-binding transcription factor activity
HVX57_RS12795	COG2840	Smr protein MutS2
HVX57_RS12800	COG1414	Transcriptional regulator
HVX57_RS12810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVX57_RS12815	COG0183	Belongs to the thiolase family
HVX57_RS12825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HVX57_RS12830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX57_RS12835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS12835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS12855	COG4565	transcriptional regulatory protein
HVX57_RS12860	COG3290	protein histidine kinase activity
HVX57_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS12875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HVX57_RS12890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVX57_RS12900	COG0679	Auxin Efflux Carrier
HVX57_RS12935	COG0628	permease
HVX57_RS12950	COG5001	Diguanylate cyclase
HVX57_RS12950	COG3300	MHYT domain
HVX57_RS12955	COG3591	Belongs to the peptidase S1B family
HVX57_RS12970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HVX57_RS12975	COG2814	Major facilitator Superfamily
HVX57_RS12980	COG0583	DNA-binding transcription factor activity
HVX57_RS12985	COG1940	carbohydrate kinase activity
HVX57_RS12990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVX57_RS13000	COG3381	protein complex oligomerization
HVX57_RS13005	COG3302	dmso reductase anchor subunit
HVX57_RS13010	COG0437	4 iron, 4 sulfur cluster binding
HVX57_RS13015	COG0243	molybdopterin cofactor binding
HVX57_RS13030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX57_RS13045	COG4948	Mandelate Racemase Muconate Lactonizing
HVX57_RS13050	COG1063	alcohol dehydrogenase
HVX57_RS13055	COG0477	Major facilitator Superfamily
HVX57_RS13060	COG0246	Mannitol dehydrogenase
HVX57_RS13065	COG0589	response to stress
HVX57_RS13070	COG1802	Transcriptional regulator
HVX57_RS13075	COG4221	oxidoreductase activity
HVX57_RS13080	COG0339	signal peptide processing
HVX57_RS13090	COG0339	signal peptide processing
HVX57_RS13100	COG3122	Protein conserved in bacteria
HVX57_RS13125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HVX57_RS13130	COG2223	nitrite transmembrane transporter activity
HVX57_RS13150	COG2200	EAL domain
HVX57_RS13195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HVX57_RS13230	COG2814	Major facilitator Superfamily
HVX57_RS13235	COG0697	spore germination
HVX57_RS13275	COG0039	L-malate dehydrogenase activity
HVX57_RS13285	COG0583	DNA-binding transcription factor activity
HVX57_RS13290	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS13305	COG2199	diguanylate cyclase activity
HVX57_RS13350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS13355	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX57_RS13390	COG2814	Major facilitator Superfamily
HVX57_RS13410	COG3433	isochorismatase activity
HVX57_RS13410	COG1535	isochorismatase
HVX57_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS13460	COG0477	Major facilitator Superfamily
HVX57_RS13475	COG2011	ABC-type metal ion transport system permease component
HVX57_RS13495	COG4628	conserved protein (DUF2132)
HVX57_RS13510	COG1126	abc transporter atp-binding protein
HVX57_RS13515	COG0765	amino acid transport
HVX57_RS13520	COG0765	amino acid transport
HVX57_RS13540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVX57_RS13545	COG2207	Transcriptional regulator
HVX57_RS13560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HVX57_RS13565	COG1446	asparaginase
HVX57_RS13570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS13585	COG1120	ATPase activity
HVX57_RS13590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX57_RS13595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS13615	COG3775	system Galactitol-specific IIC component
HVX57_RS13620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVX57_RS13625	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS13630	COG1070	Carbohydrate kinase
HVX57_RS13660	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS13665	COG1129	ABC transporter
HVX57_RS13675	COG1609	Transcriptional regulator
HVX57_RS13685	COG0693	protein deglycase activity
HVX57_RS13700	COG0412	Dienelactone hydrolase
HVX57_RS13705	COG0583	DNA-binding transcription factor activity
HVX57_RS13730	COG2841	Protein conserved in bacteria
HVX57_RS13755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS13770	COG4821	SIS domain
HVX57_RS13825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVX57_RS13855	COG3539	Fimbrial protein
HVX57_RS13875	COG3121	Chaperone
HVX57_RS13925	COG3391	amine dehydrogenase activity
HVX57_RS13930	COG4771	TonB-dependent receptor
HVX57_RS13940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX57_RS13955	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS13965	COG1609	Transcriptional regulator
HVX57_RS13995	COG1652	LysM domain
HVX57_RS14020	COG0814	amino acid
HVX57_RS14025	COG1760	l-serine dehydratase
HVX57_RS14040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVX57_RS14050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS14055	COG0765	amino acid transport
HVX57_RS14060	COG1126	abc transporter atp-binding protein
HVX57_RS14075	COG1309	transcriptional regulator
HVX57_RS14085	COG2814	Major facilitator Superfamily
HVX57_RS14190	COG4977	sequence-specific DNA binding
HVX57_RS14200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HVX57_RS14205	COG0022	dehydrogenase e1 component
HVX57_RS14210	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX57_RS14215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX57_RS14230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HVX57_RS14240	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS14250	COG0401	homolog of Blt101
HVX57_RS14260	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HVX57_RS14265	COG2200	EAL domain
HVX57_RS14265	COG2771	luxR family
HVX57_RS14310	COG1609	Transcriptional regulator
HVX57_RS14315	COG1082	Xylose isomerase domain protein TIM barrel
HVX57_RS14320	COG0673	inositol 2-dehydrogenase activity
HVX57_RS14325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HVX57_RS14330	COG1116	anion transmembrane transporter activity
HVX57_RS14335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX57_RS14340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX57_RS14345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVX57_RS14350	COG0076	glutamate decarboxylase activity
HVX57_RS14365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HVX57_RS14365	COG0519	Catalyzes the synthesis of GMP from XMP
HVX57_RS14380	COG0439	Biotin carboxylase
HVX57_RS14395	COG1116	anion transmembrane transporter activity
HVX57_RS14395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX57_RS14420	COG1280	lysine exporter protein (LysE YggA)
HVX57_RS14465	COG2271	Major facilitator Superfamily
HVX57_RS14475	COG0583	DNA-binding transcription factor activity
HVX57_RS14480	COG0583	DNA-binding transcription factor activity
HVX57_RS14490	COG1280	lysine exporter protein (LysE YggA)
HVX57_RS14495	COG0243	molybdopterin cofactor binding
HVX57_RS14500	COG3781	membrane
HVX57_RS14515	COG1764	response to oxidative stress
HVX57_RS14545	COG0488	(ABC) transporter
HVX57_RS14565	COG1064	alcohol dehydrogenase
HVX57_RS14595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX57_RS14605	COG2814	Major facilitator Superfamily
HVX57_RS14620	COG2864	formate dehydrogenase
HVX57_RS14625	COG0437	4 iron, 4 sulfur cluster binding
HVX57_RS14635	COG0697	spore germination
HVX57_RS14680	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVX57_RS14685	COG1140	nitrate reductase beta subunit
HVX57_RS14690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVX57_RS14695	COG2181	nitrate reductase activity
HVX57_RS14700	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVX57_RS14705	COG1178	ABC-type Fe3 transport system permease component
HVX57_RS14710	COG1840	ABC-type Fe3 transport system, periplasmic component
HVX57_RS14715	COG3842	ATPase activity
HVX57_RS14720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX57_RS14725	COG4977	sequence-specific DNA binding
HVX57_RS14735	COG2211	Major facilitator Superfamily
HVX57_RS14750	COG0625	glutathione transferase activity
HVX57_RS14755	COG1609	Transcriptional regulator
HVX57_RS14765	COG2271	Major facilitator Superfamily
HVX57_RS14775	COG1126	abc transporter atp-binding protein
HVX57_RS14795	COG1473	amidohydrolase
HVX57_RS14800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX57_RS14825	COG4772	TonB-dependent receptor
HVX57_RS14830	COG3691	Protein conserved in bacteria
HVX57_RS14840	COG2130	NADP-dependent
HVX57_RS14855	COG1247	-acetyltransferase
HVX57_RS14860	COG3238	Protein conserved in bacteria
HVX57_RS14870	COG0747	negative chemotaxis
HVX57_RS14875	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS14880	COG4677	pectinesterase activity
HVX57_RS14885	COG0596	Alpha beta hydrolase
HVX57_RS14910	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS14915	COG1177	transmembrane transport
HVX57_RS14920	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX57_RS14925	COG3842	ATPase activity
HVX57_RS14930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX57_RS14935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX57_RS14940	COG1271	oxidase subunit
HVX57_RS14945	COG1294	oxidase, subunit
HVX57_RS14960	COG0826	peptidase U32
HVX57_RS14965	COG1396	sequence-specific DNA binding
HVX57_RS14970	COG3135	benzoate transporter
HVX57_RS14975	COG2207	Transcriptional regulator
HVX57_RS14980	COG0697	spore germination
HVX57_RS14990	COG0747	negative chemotaxis
HVX57_RS14995	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVX57_RS15000	COG0500	methyltransferase
HVX57_RS15005	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVX57_RS15010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX57_RS15015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX57_RS15025	COG1335	isochorismatase
HVX57_RS15030	COG2272	Belongs to the type-B carboxylesterase lipase family
HVX57_RS15035	COG5383	Protein conserved in bacteria
HVX57_RS15040	COG3485	protocatechuate 3,4-dioxygenase
HVX57_RS15045	COG3485	protocatechuate 3,4-dioxygenase
HVX57_RS15050	COG0583	DNA-binding transcription factor activity
HVX57_RS15080	COG3038	cytochrome b561
HVX57_RS15105	COG3706	GGDEF domain
HVX57_RS15110	COG0583	DNA-binding transcription factor activity
HVX57_RS15115	COG0456	acetyltransferase
HVX57_RS15120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVX57_RS15125	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS15130	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX57_RS15135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVX57_RS15155	COG1538	Outer membrane efflux protein
HVX57_RS15160	COG4122	O-methyltransferase activity
HVX57_RS15165	COG1643	Atp-dependent helicase
HVX57_RS15180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX57_RS15185	COG3327	negative regulation of DNA-templated transcription, initiation
HVX57_RS15190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVX57_RS15195	COG0183	Belongs to the thiolase family
HVX57_RS15200	COG2050	protein possibly involved in aromatic compounds catabolism
HVX57_RS15205	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVX57_RS15210	COG1024	Enoyl-CoA hydratase
HVX57_RS15215	COG1024	Enoyl-CoA hydratase
HVX57_RS15220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX57_RS15225	COG2151	metal-sulfur cluster biosynthetic enzyme
HVX57_RS15230	COG3396	Phenylacetate-CoA oxygenase
HVX57_RS15235	COG3460	Phenylacetate-CoA oxygenase
HVX57_RS15240	COG3396	Phenylacetate-CoA oxygenase
HVX57_RS15245	COG2030	dehydratase
HVX57_RS15245	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS15265	COG3813	Protein conserved in bacteria
HVX57_RS15270	COG0583	DNA-binding transcription factor activity
HVX57_RS15285	COG1335	isochorismatase
HVX57_RS15295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVX57_RS15305	COG2814	Major facilitator Superfamily
HVX57_RS15310	COG1335	isochorismatase
HVX57_RS15315	COG4977	sequence-specific DNA binding
HVX57_RS15320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVX57_RS15335	COG0583	DNA-binding transcription factor activity
HVX57_RS15365	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVX57_RS15370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX57_RS15385	COG0406	alpha-ribazole phosphatase activity
HVX57_RS15400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS15405	COG3708	Transcriptional regulator
HVX57_RS15405	COG2207	Transcriptional regulator
HVX57_RS15410	COG2207	Transcriptional regulator
HVX57_RS15425	COG1566	PFAM secretion protein HlyD family protein
HVX57_RS15450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVX57_RS15480	COG2072	flavoprotein involved in K transport
HVX57_RS15485	COG0583	DNA-binding transcription factor activity
HVX57_RS15490	COG1126	abc transporter atp-binding protein
HVX57_RS15495	COG5285	phytanoyl-CoA dioxygenase
HVX57_RS15510	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS15530	COG2235	arginine
HVX57_RS15540	COG2207	Transcriptional regulator
HVX57_RS15545	COG3784	Protein of unknown function (DUF1318)
HVX57_RS15555	COG2911	Protein conserved in bacteria
HVX57_RS15560	COG0586	Pfam SNARE associated Golgi protein
HVX57_RS15565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVX57_RS15570	COG3187	Heat shock protein
HVX57_RS15575	COG3042	response to heat
HVX57_RS15655	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVX57_RS15655	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVX57_RS15655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX57_RS15655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVX57_RS15660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX57_RS15670	COG0589	response to stress
HVX57_RS15700	COG0513	Belongs to the DEAD box helicase family
HVX57_RS15715	COG1349	DNA-binding transcription factor activity
HVX57_RS15720	COG0673	inositol 2-dehydrogenase activity
HVX57_RS15725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVX57_RS15730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVX57_RS15750	COG3477	response to acidic pH
HVX57_RS15755	COG2885	chlorophyll binding
HVX57_RS15755	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVX57_RS15775	COG0583	DNA-binding transcription factor activity
HVX57_RS15800	COG0789	Transcriptional regulator
HVX57_RS15810	COG0300	oxidoreductase activity
HVX57_RS15825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVX57_RS15835	COG3272	Protein of unknown function (DUF1722)
HVX57_RS15840	COG4580	involved in the transport of maltose and maltodextrins
HVX57_RS15845	COG2211	Major facilitator Superfamily
HVX57_RS15850	COG3507	Belongs to the glycosyl hydrolase 43 family
HVX57_RS15950	COG2885	chlorophyll binding
HVX57_RS15975	COG0693	protein deglycase activity
HVX57_RS15980	COG1605	Chorismate mutase
HVX57_RS15990	COG0477	Major facilitator Superfamily
HVX57_RS15995	COG1464	Belongs to the NlpA lipoprotein family
HVX57_RS16000	COG2011	ABC-type metal ion transport system permease component
HVX57_RS16020	COG4166	transmembrane transport
HVX57_RS16025	COG2866	Carboxypeptidase
HVX57_RS16030	COG4948	Mandelate Racemase Muconate Lactonizing
HVX57_RS16035	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVX57_RS16040	COG3180	Ammonia monooxygenase
HVX57_RS16055	COG3106	COG3106 Predicted ATPase
HVX57_RS16060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX57_RS16070	COG1983	PspC domain protein
HVX57_RS16080	COG1842	Phage shock protein A
HVX57_RS16085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVX57_RS16095	COG1473	amidohydrolase
HVX57_RS16110	COG4166	transmembrane transport
HVX57_RS16130	COG4171	peptide transport system, permease
HVX57_RS16140	COG4172	Belongs to the ABC transporter superfamily
HVX57_RS16145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVX57_RS16150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX57_RS16150	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX57_RS16165	COG1349	DNA-binding transcription factor activity
HVX57_RS16175	COG0023	Translation Initiation Factor
HVX57_RS16185	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVX57_RS16190	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVX57_RS16195	COG0671	phosphoesterase, PA-phosphatase related
HVX57_RS16205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVX57_RS16230	COG0616	signal peptide processing
HVX57_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS16245	COG2207	Transcriptional regulator
HVX57_RS16255	COG2211	Major facilitator Superfamily
HVX57_RS16260	COG1187	pseudouridine synthase activity
HVX57_RS16350	COG0009	L-threonylcarbamoyladenylate synthase
HVX57_RS16360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVX57_RS16365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX57_RS16365	COG0512	Glutamine amidotransferase of anthranilate synthase
HVX57_RS16370	COG0134	indole-3-glycerol-phosphate synthase activity
HVX57_RS16370	COG0135	phosphoribosylanthranilate isomerase activity
HVX57_RS16395	COG0583	DNA-binding transcription factor activity
HVX57_RS16410	COG3047	cAMP biosynthetic process
HVX57_RS16425	COG0038	chloride channel
HVX57_RS16445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX57_RS16450	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS16455	COG1988	membrane-bound metal-dependent
HVX57_RS16475	COG0753	catalase activity
HVX57_RS16485	COG1486	melibiose metabolic process
HVX57_RS16490	COG1917	Cupin 2, conserved barrel domain protein
HVX57_RS16490	COG2169	Transcriptional regulator
HVX57_RS16495	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX57_RS16500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS16505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS16510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX57_RS16520	COG0322	excinuclease ABC activity
HVX57_RS16525	COG4907	membrane protein (DUF2207)
HVX57_RS16530	COG1704	LemA family
HVX57_RS16535	COG3678	ATP-independent chaperone mediated protein folding
HVX57_RS16555	COG3138	arginine N-succinyltransferase
HVX57_RS16565	COG0708	Exodeoxyribonuclease III
HVX57_RS16570	COG0398	Pfam SNARE associated Golgi protein
HVX57_RS16575	COG0398	Pfam SNARE associated Golgi protein
HVX57_RS16580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX57_RS16585	COG4134	Bacterial extracellular solute-binding protein
HVX57_RS16590	COG4135	transport system, permease component
HVX57_RS16595	COG4136	ATPase activity
HVX57_RS16600	COG2897	thiosulfate sulfurtransferase activity
HVX57_RS16605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVX57_RS16610	COG0494	nUDIX hydrolase
HVX57_RS16620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX57_RS16625	COG0709	Synthesizes selenophosphate from selenide and ATP
HVX57_RS16635	COG0778	Nitroreductase
HVX57_RS16640	COG0616	signal peptide processing
HVX57_RS16645	COG0252	asparaginase activity
HVX57_RS16650	COG1335	isochorismatase
HVX57_RS16655	COG2814	Major facilitator Superfamily
HVX57_RS16660	COG1349	DNA-binding transcription factor activity
HVX57_RS16665	COG0667	Aldo Keto reductase
HVX57_RS16670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS16675	COG0191	fructose-bisphosphate aldolase activity
HVX57_RS16680	COG1063	alcohol dehydrogenase
HVX57_RS16685	COG2271	Major facilitator Superfamily
HVX57_RS16690	COG1063	alcohol dehydrogenase
HVX57_RS16705	COG3139	Protein of unknown function (DUF1315)
HVX57_RS16725	COG0656	L-ascorbic acid biosynthetic process
HVX57_RS16730	COG3713	MltA-interacting MipA family protein
HVX57_RS16735	COG2766	serine protein kinase
HVX57_RS16745	COG0859	PFAM glycosyl transferase family 9
HVX57_RS16750	COG2199	diguanylate cyclase activity
HVX57_RS16755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX57_RS16765	COG2207	Transcriptional regulator
HVX57_RS16770	COG2807	transmembrane transport
HVX57_RS16775	COG0504	CTP synthase activity
HVX57_RS16780	COG1683	Conserved Protein
HVX57_RS16785	COG3189	MarR family transcriptional regulator
HVX57_RS16790	COG3042	response to heat
HVX57_RS16795	COG2199	diguanylate cyclase activity
HVX57_RS16795	COG2203	Gaf domain
HVX57_RS16815	COG3182	Iron-regulated membrane protein
HVX57_RS16825	COG1560	Kdo2-lipid A biosynthetic process
HVX57_RS16830	COG2226	methyltransferase
HVX57_RS16835	COG1595	DNA-templated transcription, initiation
HVX57_RS16840	COG3712	iron ion homeostasis
HVX57_RS16845	COG4772	TonB-dependent receptor
HVX57_RS16850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HVX57_RS16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS16860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS16865	COG1120	ATPase activity
HVX57_RS16875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HVX57_RS16880	COG3706	GGDEF domain
HVX57_RS16885	COG0538	isocitrate dehydrogenase activity
HVX57_RS16890	COG1187	pseudouridine synthase activity
HVX57_RS16910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVX57_RS16915	COG2814	Major facilitator Superfamily
HVX57_RS16925	COG0745	RESPONSE REGULATOR receiver
HVX57_RS16930	COG2205	protein histidine kinase activity
HVX57_RS16935	COG2850	peptidyl-arginine hydroxylation
HVX57_RS16955	COG1177	transmembrane transport
HVX57_RS16970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX57_RS16975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX57_RS16980	COG0698	ribose 5-phosphate isomerase
HVX57_RS16995	COG3395	kinase activity
HVX57_RS17010	COG2390	Transcriptional regulator
HVX57_RS17015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVX57_RS17025	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX57_RS17030	COG1136	(ABC) transporter
HVX57_RS17035	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX57_RS17040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVX57_RS17045	COG1376	ErfK ybiS ycfS ynhG family protein
HVX57_RS17045	COG1388	LysM domain
HVX57_RS17055	COG1309	transcriptional regulator
HVX57_RS17065	COG3134	Outer membrane lipoprotein
HVX57_RS17070	COG1252	NADH dehydrogenase
HVX57_RS17095	COG5633	Lipoprotein
HVX57_RS17100	COG0537	adenosine 5'-monophosphoramidase activity
HVX57_RS17105	COG4773	Receptor
HVX57_RS17115	COG0084	hydrolase, TatD family'
HVX57_RS17120	COG0470	DNA polymerase III
HVX57_RS17130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVX57_RS17135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX57_RS17140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX57_RS17155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVX57_RS17175	COG1399	metal-binding, possibly nucleic acid-binding protein
HVX57_RS17180	COG0424	maF-like protein
HVX57_RS17195	COG1530	ribonuclease E activity
HVX57_RS17200	COG0583	DNA-binding transcription factor activity
HVX57_RS17205	COG2814	Major facilitator Superfamily
HVX57_RS17215	COG0673	inositol 2-dehydrogenase activity
HVX57_RS17225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX57_RS17235	COG2999	glutathione oxidoreductase activity
HVX57_RS17275	COG1560	Kdo2-lipid A biosynthetic process
HVX57_RS17290	COG5645	(Lipo)protein
HVX57_RS17330	COG3381	protein complex oligomerization
HVX57_RS17350	COG0583	DNA-binding transcription factor activity
HVX57_RS17360	COG1335	isochorismatase
HVX57_RS17380	COG3850	Histidine kinase
HVX57_RS17380	COG5002	protein histidine kinase activity
HVX57_RS17400	COG1702	phosphate starvation-inducible protein PhoH
HVX57_RS17410	COG2822	iron ion transport
HVX57_RS17420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX57_RS17430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVX57_RS17445	COG1309	transcriptional regulator
HVX57_RS17480	COG2233	PERMEase
HVX57_RS17485	COG3729	General stress protein
HVX57_RS17515	COG0531	amino acid
HVX57_RS17520	COG0174	glutamine synthetase
HVX57_RS17525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVX57_RS17530	COG1917	Cupin 2, conserved barrel domain protein
HVX57_RS17530	COG1396	sequence-specific DNA binding
HVX57_RS17535	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS17540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVX57_RS17545	COG0583	DNA-binding transcription factor activity
HVX57_RS17550	COG0473	3-isopropylmalate dehydrogenase activity
HVX57_RS17555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS17555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS17555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX57_RS17560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS17565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS17570	COG1882	Formate acetyltransferase
HVX57_RS17575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX57_RS17580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX57_RS17590	COG2207	Transcriptional regulator
HVX57_RS17595	COG3706	GGDEF domain
HVX57_RS17610	COG1605	Chorismate mutase
HVX57_RS17610	COG0287	Prephenate dehydrogenase
HVX57_RS17620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVX57_RS17635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HVX57_RS17700	COG1953	Uracil, thiamine, allantoin
HVX57_RS17705	COG0402	S-adenosylhomocysteine deaminase activity
HVX57_RS17710	COG2351	hydroxyisourate hydrolase activity
HVX57_RS17720	COG2233	PERMEase
HVX57_RS17725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX57_RS17785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX57_RS17795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX57_RS17810	COG5002	protein histidine kinase activity
HVX57_RS17815	COG0745	RESPONSE REGULATOR receiver
HVX57_RS17825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX57_RS17830	COG1278	Cold shock
HVX57_RS17835	COG1278	Cold shock
HVX57_RS17840	COG0471	metal ion transport
HVX57_RS17855	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HVX57_RS17875	COG3052	prosthetic group binding
HVX57_RS17880	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVX57_RS17890	COG2814	Major facilitator Superfamily
HVX57_RS17895	COG2828	Protein conserved in bacteria
HVX57_RS17900	COG0583	DNA-binding transcription factor activity
HVX57_RS17925	COG2814	Major facilitator Superfamily
HVX57_RS17950	COG1486	melibiose metabolic process
HVX57_RS17955	COG2207	Transcriptional regulator
HVX57_RS17965	COG0477	Major facilitator Superfamily
HVX57_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS17980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS17990	COG1126	abc transporter atp-binding protein
HVX57_RS17995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX57_RS18005	COG0006	proline dipeptidase activity
HVX57_RS18010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVX57_RS18015	COG0504	CTP synthase activity
HVX57_RS18020	COG0436	Aminotransferase
HVX57_RS18025	COG2188	Transcriptional regulator
HVX57_RS18035	COG3715	PTS system
HVX57_RS18040	COG3716	PTS system mannose fructose sorbose family IID component
HVX57_RS18045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS18050	COG4821	SIS domain
HVX57_RS18055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HVX57_RS18060	COG4821	SIS domain
HVX57_RS18085	COG0670	Belongs to the BI1 family
HVX57_RS18100	COG2207	Transcriptional regulator
HVX57_RS18105	COG1881	PFAM PEBP family protein
HVX57_RS18130	COG0438	transferase activity, transferring glycosyl groups
HVX57_RS18135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS18140	COG2274	protein secretion by the type I secretion system
HVX57_RS18170	COG1832	CoA-binding protein
HVX57_RS18180	COG0210	DNA helicase
HVX57_RS18185	COG3304	Inner membrane component domain
HVX57_RS18190	COG1289	transmembrane transporter activity
HVX57_RS18195	COG3070	regulator of competence-specific genes
HVX57_RS18215	COG1067	ATP-dependent peptidase activity
HVX57_RS18225	COG3130	regulation of translation
HVX57_RS18230	COG3009	Protein conserved in bacteria
HVX57_RS18235	COG3008	intermembrane lipid transfer
HVX57_RS18235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX57_RS18240	COG2995	paraquat-inducible protein a
HVX57_RS18245	COG0488	(ABC) transporter
HVX57_RS18255	COG3217	Mosc domain protein beta barrel domain protein
HVX57_RS18255	COG0633	Ferredoxin
HVX57_RS18270	COG0431	NADPH-dependent FMN reductase
HVX57_RS18275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX57_RS18280	COG1116	anion transmembrane transporter activity
HVX57_RS18285	COG0308	aminopeptidase N
HVX57_RS18300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX57_RS18305	COG1448	Aminotransferase
HVX57_RS18310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVX57_RS18315	COG3108	Peptidase M15
HVX57_RS18320	COG2989	Protein conserved in bacteria
HVX57_RS18330	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVX57_RS18340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVX57_RS18345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX57_RS18350	COG3173	Aminoglycoside phosphotransferase
HVX57_RS18365	COG3214	Protein conserved in bacteria
HVX57_RS18375	COG1132	(ABC) transporter
HVX57_RS18380	COG0658	competence protein
HVX57_RS18380	COG2333	competence protein COMEC
HVX57_RS18390	COG0539	negative regulation of cytoplasmic translation
HVX57_RS18410	COG2323	membrane
HVX57_RS18415	COG1944	ATP diphosphatase activity
HVX57_RS18420	COG2116	formate transmembrane transporter activity
HVX57_RS18425	COG1882	Formate acetyltransferase
HVX57_RS18430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX57_RS18450	COG3959	Transketolase, thiamine diphosphate binding domain
HVX57_RS18455	COG3958	Transketolase
HVX57_RS18460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS18465	COG0477	Major facilitator Superfamily
HVX57_RS18470	COG3302	dmso reductase anchor subunit
HVX57_RS18475	COG0437	4 iron, 4 sulfur cluster binding
HVX57_RS18480	COG0243	molybdopterin cofactor binding
HVX57_RS18490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVX57_RS18500	COG1674	ftsk spoiiie
HVX57_RS18500	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX57_RS18510	COG0492	ferredoxin-NADP+ reductase activity
HVX57_RS18515	COG4988	ABC transporter
HVX57_RS18520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVX57_RS18530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HVX57_RS18535	COG0542	response to heat
HVX57_RS18545	COG1278	Cold shock
HVX57_RS18555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS18560	COG3593	DNA synthesis involved in DNA repair
HVX57_RS18565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVX57_RS18570	COG2431	L-lysine efflux transmembrane transporter activity
HVX57_RS18580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX57_RS18590	COG0028	Belongs to the TPP enzyme family
HVX57_RS18595	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVX57_RS18600	COG0702	epimerase
HVX57_RS18605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX57_RS18610	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVX57_RS18615	COG0393	Putative heavy-metal-binding
HVX57_RS18625	COG1126	abc transporter atp-binding protein
HVX57_RS18630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS18635	COG4215	(ABC) transporter
HVX57_RS18640	COG4160	amino acid transport
HVX57_RS18645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS18650	COG5002	protein histidine kinase activity
HVX57_RS18655	COG0745	RESPONSE REGULATOR receiver
HVX57_RS18670	COG1177	transmembrane transport
HVX57_RS18675	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX57_RS18680	COG3842	ATPase activity
HVX57_RS18685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX57_RS18700	COG0778	Nitroreductase
HVX57_RS18725	COG3226	Transcriptional regulator
HVX57_RS18730	COG0738	Major facilitator superfamily
HVX57_RS18735	COG0561	phosphatase activity
HVX57_RS18740	COG2814	Major facilitator Superfamily
HVX57_RS18745	COG0671	phosphoesterase, PA-phosphatase related
HVX57_RS18750	COG1349	DNA-binding transcription factor activity
HVX57_RS18755	COG1686	Belongs to the peptidase S11 family
HVX57_RS18945	COG4725	Belongs to the MT-A70-like family
HVX57_RS19015	COG1846	Transcriptional regulator
HVX57_RS19065	COG0582	viral genome integration into host DNA
HVX57_RS19070	COG0625	glutathione transferase activity
HVX57_RS19075	COG2133	pyrroloquinoline quinone binding
HVX57_RS19110	COG0747	negative chemotaxis
HVX57_RS19120	COG1446	asparaginase
HVX57_RS19125	COG0303	'Molybdopterin
HVX57_RS19130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX57_RS19135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX57_RS19140	COG1882	Formate acetyltransferase
HVX57_RS19145	COG0561	phosphatase activity
HVX57_RS19155	COG1609	Transcriptional regulator
HVX57_RS19160	COG2271	Major facilitator Superfamily
HVX57_RS19170	COG0488	(ABC) transporter
HVX57_RS19180	COG1376	ErfK ybiS ycfS ynhG family protein
HVX57_RS19185	COG2188	Transcriptional regulator
HVX57_RS19190	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS19195	COG0667	Aldo Keto reductase
HVX57_RS19200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX57_RS19215	COG2194	sulfuric ester hydrolase activity
HVX57_RS19220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVX57_RS19235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS19240	COG0765	amino acid transport
HVX57_RS19245	COG1126	abc transporter atp-binding protein
HVX57_RS19255	COG0668	transmembrane transport
HVX57_RS19270	COG4774	siderophore transport
HVX57_RS19280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVX57_RS19290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX57_RS19300	COG0513	Belongs to the DEAD box helicase family
HVX57_RS19305	COG3958	Transketolase
HVX57_RS19310	COG3959	Transketolase, thiamine diphosphate binding domain
HVX57_RS19315	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS19320	COG2271	Major facilitator Superfamily
HVX57_RS19325	COG0583	DNA-binding transcription factor activity
HVX57_RS19330	COG1309	transcriptional regulator
HVX57_RS19335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS19340	COG1131	(ABC) transporter
HVX57_RS19345	COG0842	Transport permease protein
HVX57_RS19350	COG0842	Transport permease protein
HVX57_RS19360	COG3568	Endonuclease Exonuclease Phosphatase
HVX57_RS19365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX57_RS19370	COG0392	lysyltransferase activity
HVX57_RS19375	COG0670	Belongs to the BI1 family
HVX57_RS19380	COG0314	molybdopterin synthase activity
HVX57_RS19385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVX57_RS19395	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX57_RS19415	COG0745	RESPONSE REGULATOR receiver
HVX57_RS19440	COG2226	methyltransferase
HVX57_RS19455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVX57_RS19460	COG1881	PFAM PEBP family protein
HVX57_RS19495	COG4677	pectinesterase activity
HVX57_RS19510	COG0789	Transcriptional regulator
HVX57_RS19515	COG2200	EAL domain
HVX57_RS19550	COG0561	phosphatase activity
HVX57_RS19560	COG4149	molybdate abc transporter
HVX57_RS19565	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVX57_RS19575	COG3585	molybdate ion transport
HVX57_RS19575	COG2005	Transcriptional regulator
HVX57_RS19580	COG1119	ATPase activity
HVX57_RS19585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVX57_RS19590	COG1085	galactose-1-phosphate uridylyltransferase
HVX57_RS19600	COG2017	converts alpha-aldose to the beta-anomer
HVX57_RS19610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX57_RS19630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HVX57_RS19660	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVX57_RS19665	COG2885	chlorophyll binding
HVX57_RS19675	COG3064	Membrane
HVX57_RS19680	COG0848	biopolymer transport protein
HVX57_RS19685	COG0811	peptide transport
HVX57_RS19690	COG0824	Thioesterase
HVX57_RS19695	COG3790	cyd operon protein YbgE
HVX57_RS19700	COG4890	Cyd operon protein YbgT
HVX57_RS19705	COG1294	oxidase, subunit
HVX57_RS19710	COG1271	oxidase subunit
HVX57_RS19715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX57_RS19725	COG4865	methylaspartate mutase activity
HVX57_RS19730	COG3799	methylaspartate ammonia-lyase activity
HVX57_RS19745	COG1301	dicarboxylic acid transport
HVX57_RS19755	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS19755	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX57_RS19765	COG0583	DNA-binding transcription factor activity
HVX57_RS19775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX57_RS19785	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX57_RS19790	COG0567	Dehydrogenase, E1 component
HVX57_RS19795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX57_RS19800	COG1053	succinate dehydrogenase
HVX57_RS19805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVX57_RS19815	COG0372	Belongs to the citrate synthase family
HVX57_RS19845	COG1984	allophanate hydrolase subunit 2
HVX57_RS19850	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVX57_RS19855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVX57_RS19865	COG0415	Belongs to the DNA photolyase family
HVX57_RS19895	COG2205	protein histidine kinase activity
HVX57_RS19900	COG0745	RESPONSE REGULATOR receiver
HVX57_RS19910	COG3623	hexulose-6-phosphate isomerase
HVX57_RS19915	COG1070	Carbohydrate kinase
HVX57_RS19920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS19925	COG1129	ABC transporter
HVX57_RS19930	COG1879	ABC-type sugar transport system periplasmic component
HVX57_RS19935	COG1063	alcohol dehydrogenase
HVX57_RS19940	COG1349	DNA-binding transcription factor activity
HVX57_RS19950	COG0033	Phosphoglucomutase
HVX57_RS19955	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVX57_RS19960	COG0596	Alpha beta hydrolase
HVX57_RS19975	COG0735	belongs to the Fur family
HVX57_RS19980	COG0583	DNA-binding transcription factor activity
HVX57_RS19985	COG1053	succinate dehydrogenase
HVX57_RS20025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX57_RS20030	COG1846	Transcriptional regulator
HVX57_RS20030	COG1940	carbohydrate kinase activity
HVX57_RS20035	COG0647	UMP catabolic process
HVX57_RS20040	COG0367	asparagine synthase
HVX57_RS20085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX57_RS20095	COG1702	phosphate starvation-inducible protein PhoH
HVX57_RS20100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HVX57_RS20105	COG4535	Mg2 and Co2 transporter CorC
HVX57_RS20120	COG0765	amino acid transport
HVX57_RS20125	COG0765	amino acid transport
HVX57_RS20130	COG1126	abc transporter atp-binding protein
HVX57_RS20135	COG2831	hemolysin activation secretion protein
HVX57_RS20145	COG2888	peptidyl-tyrosine sulfation
HVX57_RS20160	COG1466	dna polymerase III delta subunit
HVX57_RS20175	COG0799	negative regulation of ribosome biogenesis
HVX57_RS20185	COG0768	penicillin binding
HVX57_RS20190	COG0772	Belongs to the SEDS family
HVX57_RS20195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX57_RS20200	COG1686	Belongs to the peptidase S11 family
HVX57_RS20215	COG0583	DNA-binding transcription factor activity
HVX57_RS20225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX57_RS20230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX57_RS20250	COG3069	C4-dicarboxylate transmembrane transporter activity
HVX57_RS20255	COG3719	Belongs to the RNase T2 family
HVX57_RS20260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX57_RS20270	COG3634	alkyl hydroperoxide reductase activity
HVX57_RS20280	COG0583	DNA-binding transcription factor activity
HVX57_RS20285	COG3969	phosphoadenosine phosphosulfate
HVX57_RS20290	COG1475	DNA binding
HVX57_RS20295	COG0436	Aminotransferase
HVX57_RS20300	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HVX57_RS20305	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HVX57_RS20320	COG1129	ABC transporter
HVX57_RS20325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS20330	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS20340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVX57_RS20355	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVX57_RS20365	COG0402	S-adenosylhomocysteine deaminase activity
HVX57_RS20375	COG0483	inositol monophosphate 1-phosphatase activity
HVX57_RS20380	COG2271	Major facilitator Superfamily
HVX57_RS20410	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS20415	COG1129	ABC transporter
HVX57_RS20420	COG0371	Dehydrogenase
HVX57_RS20435	COG2879	small protein
HVX57_RS20440	COG1966	Carbon starvation protein
HVX57_RS20450	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS20455	COG3433	isochorismatase activity
HVX57_RS20455	COG1535	isochorismatase
HVX57_RS20460	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVX57_RS20465	COG1169	isochorismate synthase
HVX57_RS20470	COG4592	Periplasmic binding protein
HVX57_RS20485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS20490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS20495	COG1120	ATPase activity
HVX57_RS20505	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVX57_RS20505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVX57_RS20510	COG3251	PFAM MbtH domain protein
HVX57_RS20515	COG2382	esterase
HVX57_RS20520	COG4771	TonB-dependent receptor
HVX57_RS20525	COG2977	Belongs to the P-Pant transferase superfamily
HVX57_RS20530	COG3958	Transketolase
HVX57_RS20535	COG3959	Transketolase, thiamine diphosphate binding domain
HVX57_RS20540	COG2390	Transcriptional regulator
HVX57_RS20545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HVX57_RS20550	COG1879	ABC-type sugar transport system periplasmic component
HVX57_RS20560	COG1129	ABC transporter
HVX57_RS20565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS20575	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS20585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVX57_RS20615	COG4221	oxidoreductase activity
HVX57_RS20625	COG0765	amino acid transport
HVX57_RS20645	COG1280	lysine exporter protein (LysE YggA)
HVX57_RS20655	COG0697	spore germination
HVX57_RS20665	COG0154	amidase activity
HVX57_RS20670	COG0444	Belongs to the ABC transporter superfamily
HVX57_RS20675	COG4608	Belongs to the ABC transporter superfamily
HVX57_RS20680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX57_RS20700	COG3698	Phosphodiester glycosidase
HVX57_RS20730	COG2211	Major facilitator Superfamily
HVX57_RS20735	COG1621	beta-fructofuranosidase activity
HVX57_RS20765	COG2315	Protein conserved in bacteria
HVX57_RS20770	COG0778	Nitroreductase
HVX57_RS20780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS20790	COG3716	PTS system mannose fructose sorbose family IID component
HVX57_RS20795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVX57_RS20800	COG2222	sugar isomerase
HVX57_RS20805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVX57_RS20805	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HVX57_RS20815	COG0477	Major facilitator Superfamily
HVX57_RS20820	COG0668	transmembrane transport
HVX57_RS20830	COG0494	nUDIX hydrolase
HVX57_RS20850	COG3188	usher protein
HVX57_RS20865	COG2771	luxR family
HVX57_RS20870	COG0583	DNA-binding transcription factor activity
HVX57_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS20895	COG2211	Major facilitator Superfamily
HVX57_RS20900	COG1113	amino acid transport
HVX57_RS20910	COG0667	Aldo Keto reductase
HVX57_RS20915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS20920	COG1473	amidohydrolase
HVX57_RS20940	COG4139	cobalamin transport
HVX57_RS20945	COG1120	ATPase activity
HVX57_RS20985	COG3711	transcriptional antiterminator
HVX57_RS20990	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS20995	COG1263	PTS System
HVX57_RS20995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS20995	COG2190	(PTS) system
HVX57_RS21000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS21005	COG1129	ABC transporter
HVX57_RS21020	COG0673	inositol 2-dehydrogenase activity
HVX57_RS21030	COG2367	Beta-lactamase
HVX57_RS21045	COG3104	oligopeptide transport
HVX57_RS21055	COG0531	amino acid
HVX57_RS21060	COG3710	Transcriptional regulator
HVX57_RS21070	COG0583	DNA-binding transcription factor activity
HVX57_RS21080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVX57_RS21090	COG1285	pathogenesis
HVX57_RS21095	COG2211	Major facilitator Superfamily
HVX57_RS21130	COG2501	S4 domain
HVX57_RS21140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVX57_RS21155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVX57_RS21160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVX57_RS21180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVX57_RS21185	COG4181	ATPase activity
HVX57_RS21190	COG2755	lipolytic protein G-D-S-L family
HVX57_RS21195	COG0300	oxidoreductase activity
HVX57_RS21200	COG3118	belongs to the thioredoxin family
HVX57_RS21205	COG0390	transport system, permease component
HVX57_RS21210	COG4619	ABC transporter
HVX57_RS21215	COG0330	HflC and HflK could
HVX57_RS21220	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVX57_RS21245	COG3735	TraB family
HVX57_RS21250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX57_RS21260	COG2223	nitrite transmembrane transporter activity
HVX57_RS21265	COG4651	solute:proton antiporter activity
HVX57_RS21265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVX57_RS21270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS21310	COG2832	Protein of unknown function (DUF454)
HVX57_RS21315	COG3923	Primosomal replication protein n
HVX57_RS21330	COG3264	Mechanosensitive ion channel
HVX57_RS21330	COG1196	nuclear chromosome segregation
HVX57_RS21335	COG1309	transcriptional regulator
HVX57_RS21340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS21345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX57_RS21360	COG0110	maltose O-acetyltransferase activity
HVX57_RS21380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HVX57_RS21400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS21400	COG1263	PTS System
HVX57_RS21405	COG1874	Beta-galactosidase
HVX57_RS21410	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HVX57_RS21415	COG3833	ABC-type maltose transport systems, permease component
HVX57_RS21420	COG1175	transmembrane transport
HVX57_RS21425	COG2182	Extracellular solute-binding protein
HVX57_RS21435	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVX57_RS21450	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVX57_RS21455	COG2364	Membrane
HVX57_RS21485	COG3695	enzyme binding
HVX57_RS21490	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVX57_RS21495	COG1946	Acyl-CoA thioesterase
HVX57_RS21500	COG0004	ammonium transporteR
HVX57_RS21505	COG0347	Belongs to the P(II) protein family
HVX57_RS21515	COG1132	(ABC) transporter
HVX57_RS21520	COG1132	(ABC) transporter
HVX57_RS21525	COG1522	sequence-specific DNA binding
HVX57_RS21540	COG4533	DNA binding
HVX57_RS21550	COG0824	Thioesterase
HVX57_RS21555	COG1555	photosystem II stabilization
HVX57_RS21560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX57_RS21565	COG0776	regulation of translation
HVX57_RS21570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVX57_RS21590	COG0271	Belongs to the BolA IbaG family
HVX57_RS21595	COG3056	Lipoprotein
HVX57_RS21600	COG2223	nitrite transmembrane transporter activity
HVX57_RS21605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVX57_RS21610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVX57_RS21615	COG1845	cytochrome c oxidase, subunit III
HVX57_RS21620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVX57_RS21635	COG1414	Transcriptional regulator
HVX57_RS21670	COG2211	Major facilitator Superfamily
HVX57_RS21675	COG0673	inositol 2-dehydrogenase activity
HVX57_RS21680	COG2814	Major facilitator Superfamily
HVX57_RS21690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVX57_RS21710	COG0142	geranyltranstransferase activity
HVX57_RS21720	COG0667	Aldo Keto reductase
HVX57_RS21725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVX57_RS21745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX57_RS21745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX57_RS21755	COG4238	major outer membrane lipoprotein
HVX57_RS21780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVX57_RS21790	COG1862	Preprotein translocase
HVX57_RS21805	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HVX57_RS21810	COG0450	alkyl hydroperoxide reductase
HVX57_RS21825	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HVX57_RS21835	COG1335	isochorismatase
HVX57_RS21840	COG0583	DNA-binding transcription factor activity
HVX57_RS21845	COG0366	Alpha amylase catalytic
HVX57_RS21870	COG0420	3'-5' exonuclease activity
HVX57_RS21875	COG0419	ATPase involved in DNA repair
HVX57_RS21885	COG1940	carbohydrate kinase activity
HVX57_RS21900	COG4126	flavin adenine dinucleotide binding
HVX57_RS21910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HVX57_RS21915	COG3416	Protein conserved in bacteria
HVX57_RS21925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVX57_RS21935	COG1785	Belongs to the alkaline phosphatase family
HVX57_RS21945	COG1609	Transcriptional regulator
HVX57_RS21955	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS21990	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVX57_RS22000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX57_RS22005	COG0113	porphobilinogen synthase activity
HVX57_RS22020	COG2175	clavaminate synthase activity
HVX57_RS22025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX57_RS22030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HVX57_RS22035	COG4521	taurine ABC transporter
HVX57_RS22050	COG2271	Major facilitator Superfamily
HVX57_RS22055	COG1840	ABC-type Fe3 transport system, periplasmic component
HVX57_RS22065	COG3842	ATPase activity
HVX57_RS22070	COG2040	homocysteine
HVX57_RS22075	COG0833	amino acid
HVX57_RS22085	COG4303	Ethanolamine ammonia lyase large subunit
HVX57_RS22090	COG4302	ethanolamine ammonia-lyase activity
HVX57_RS22130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS22135	COG1126	abc transporter atp-binding protein
HVX57_RS22140	COG0765	amino acid transport
HVX57_RS22145	COG0765	amino acid transport
HVX57_RS22160	COG3188	usher protein
HVX57_RS22185	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVX57_RS22195	COG3639	organic phosphonate transmembrane transporter activity
HVX57_RS22230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX57_RS22235	COG0583	DNA-binding transcription factor activity
HVX57_RS22240	COG0791	NLP P60 protein
HVX57_RS22245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX57_RS22250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HVX57_RS22255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HVX57_RS22265	COG0582	viral genome integration into host DNA
HVX57_RS22315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVX57_RS22320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HVX57_RS22335	COG1174	glycine betaine transport
HVX57_RS22350	COG2986	histidine ammonia-lyase
HVX57_RS22360	COG2188	Transcriptional regulator
HVX57_RS22365	COG0402	S-adenosylhomocysteine deaminase activity
HVX57_RS22370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX57_RS22380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVX57_RS22390	COG0477	Major facilitator Superfamily
HVX57_RS22400	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVX57_RS22405	COG3153	acetyltransferase
HVX57_RS22420	COG0246	Mannitol dehydrogenase
HVX57_RS22425	COG2186	Transcriptional regulator
HVX57_RS22445	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS22450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVX57_RS22460	COG1596	polysaccharide export
HVX57_RS22480	COG0463	Glycosyl transferase, family 2
HVX57_RS22485	COG0438	transferase activity, transferring glycosyl groups
HVX57_RS22490	COG0297	glycogen (starch) synthase activity
HVX57_RS22490	COG0438	transferase activity, transferring glycosyl groups
HVX57_RS22505	COG1045	serine acetyltransferase
HVX57_RS22525	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVX57_RS22530	COG0454	-acetyltransferase
HVX57_RS22545	COG2991	Protein conserved in bacteria
HVX57_RS22560	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HVX57_RS22565	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HVX57_RS22580	COG3034	peptidoglycan biosynthetic process
HVX57_RS22585	COG0121	glutamine amidotransferase
HVX57_RS22600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX57_RS22620	COG2226	methyltransferase
HVX57_RS22630	COG0741	lytic transglycosylase activity
HVX57_RS22630	COG1388	LysM domain
HVX57_RS22635	COG2226	methyltransferase
HVX57_RS22645	COG2814	Major facilitator Superfamily
HVX57_RS22650	COG0583	DNA-binding transcription factor activity
HVX57_RS22690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVX57_RS22700	COG2011	ABC-type metal ion transport system permease component
HVX57_RS22705	COG1464	Belongs to the NlpA lipoprotein family
HVX57_RS22715	COG1720	tRNA m6t6A37 methyltransferase activity
HVX57_RS22725	COG0791	NLP P60 protein
HVX57_RS22730	COG3015	lipoprotein NlpE involved in copper resistance
HVX57_RS22735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVX57_RS22740	COG4681	YaeQ
HVX57_RS22750	COG4568	rho-dependent transcription termination
HVX57_RS22760	COG0346	lactoylglutathione lyase activity
HVX57_RS22805	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVX57_RS22810	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVX57_RS22820	COG0750	zinc metalloprotease
HVX57_RS22825	COG0575	Belongs to the CDS family
HVX57_RS22850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HVX57_RS22860	COG0024	Methionine aminopeptidase
HVX57_RS22870	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HVX57_RS22890	COG3835	regulator
HVX57_RS22895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX57_RS22915	COG2860	membrane
HVX57_RS22935	COG5464	transposase or invertase
HVX57_RS22940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX57_RS22945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX57_RS22950	COG1120	ATPase activity
HVX57_RS22955	COG4774	siderophore transport
HVX57_RS22960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVX57_RS23045	COG1643	Atp-dependent helicase
HVX57_RS23050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVX57_RS23070	COG0617	tRNA 3'-terminal CCA addition
HVX57_RS23075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVX57_RS23095	COG0726	polysaccharide deacetylase
HVX57_RS23100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS23105	COG0842	Transport permease protein
HVX57_RS23110	COG1131	(ABC) transporter
HVX57_RS23115	COG0288	reversible hydration of carbon dioxide
HVX57_RS23125	COG4993	Dehydrogenase
HVX57_RS23130	COG2132	Multicopper oxidase
HVX57_RS23145	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX57_RS23160	COG1349	DNA-binding transcription factor activity
HVX57_RS23190	COG3064	Membrane
HVX57_RS23205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX57_RS23210	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX57_RS23215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVX57_RS23220	COG2186	Transcriptional regulator
HVX57_RS23225	COG1113	amino acid transport
HVX57_RS23230	COG2211	Major facilitator Superfamily
HVX57_RS23235	COG3940	Belongs to the glycosyl hydrolase 43 family
HVX57_RS23240	COG3725	Membrane protein required for beta-lactamase induction
HVX57_RS23255	COG4969	Belongs to the N-Me-Phe pilin family
HVX57_RS23260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVX57_RS23265	COG1459	type II secretion system
HVX57_RS23285	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HVX57_RS23290	COG0494	nUDIX hydrolase
HVX57_RS23310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVX57_RS23315	COG0849	cell division
HVX57_RS23340	COG0772	Belongs to the SEDS family
HVX57_RS23355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVX57_RS23365	COG0768	penicillin binding
HVX57_RS23385	COG1609	Transcriptional regulator
HVX57_RS23395	COG0028	Belongs to the TPP enzyme family
HVX57_RS23410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVX57_RS23435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVX57_RS23440	COG0738	Major facilitator superfamily
HVX57_RS23450	COG0583	DNA-binding transcription factor activity
HVX57_RS23455	COG2271	Major facilitator Superfamily
HVX57_RS23460	COG2814	Major facilitator Superfamily
HVX57_RS23480	COG1178	ABC-type Fe3 transport system permease component
HVX57_RS23490	COG0586	Pfam SNARE associated Golgi protein
HVX57_RS23510	COG0235	Class ii aldolase
HVX57_RS23515	COG0417	DNA replication proofreading
HVX57_RS23525	COG0564	pseudouridine synthase activity
HVX57_RS23535	COG3493	citrate carrier protein
HVX57_RS23550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVX57_RS23675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HVX57_RS23685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVX57_RS23690	COG0471	metal ion transport
HVX57_RS23695	COG0471	metal ion transport
HVX57_RS23700	COG2828	Protein conserved in bacteria
HVX57_RS23705	COG0583	DNA-binding transcription factor activity
HVX57_RS23720	COG1047	Peptidyl-prolyl cis-trans
HVX57_RS23735	COG0196	riboflavin kinase activity
HVX57_RS23745	COG0583	DNA-binding transcription factor activity
HVX57_RS23805	COG4735	regulation of single-species biofilm formation
HVX57_RS23810	COG1584	GPR1 FUN34 yaaH family protein
HVX57_RS23815	COG0477	Major facilitator Superfamily
HVX57_RS23820	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX57_RS23825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX57_RS23830	COG1115	amino acid carrier protein
HVX57_RS23840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVX57_RS23850	COG0527	aspartate kinase activity
HVX57_RS23850	COG0460	homoserine dehydrogenase
HVX57_RS23860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVX57_RS23870	COG0745	RESPONSE REGULATOR receiver
HVX57_RS23875	COG4452	Inner membrane protein CreD
HVX57_RS23880	COG2205	protein histidine kinase activity
HVX57_RS23885	COG0745	RESPONSE REGULATOR receiver
HVX57_RS23890	COG3045	CreA protein
HVX57_RS23895	COG2207	Transcriptional regulator
HVX57_RS23895	COG3708	Transcriptional regulator
HVX57_RS23915	COG0741	lytic transglycosylase activity
HVX57_RS23920	COG0488	(ABC) transporter
HVX57_RS23925	COG3385	transposase activity
HVX57_RS23940	COG0560	Phosphoserine phosphatase
HVX57_RS23945	COG3726	membrane protein affecting hemolysin expression
HVX57_RS23955	COG0813	purine-nucleoside phosphorylase activity
HVX57_RS23975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX57_RS23980	COG0084	hydrolase, TatD family'
HVX57_RS23985	COG4667	esterase of the alpha-beta hydrolase superfamily
HVX57_RS23990	COG5487	UPF0391 membrane protein
HVX57_RS23995	COG2823	Periplasmic or secreted lipoprotein
HVX57_RS24005	COG1011	Hydrolase
HVX57_RS24010	COG0456	acetyltransferase
HVX57_RS24015	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVX57_RS24045	COG3706	GGDEF domain
HVX57_RS24050	COG4114	ferric iron reductase
HVX57_RS24055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS24060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX57_RS24065	COG2197	response regulator
HVX57_RS24070	COG2197	response regulator
HVX57_RS24075	COG2207	Transcriptional regulator
HVX57_RS24085	COG2966	Psort location CytoplasmicMembrane, score
HVX57_RS24100	COG1484	DNA-dependent DNA replication
HVX57_RS24115	COG5464	transposase or invertase
HVX57_RS24125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVX57_RS24130	COG3716	PTS system mannose fructose sorbose family IID component
HVX57_RS24135	COG3715	PTS system
HVX57_RS24150	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HVX57_RS24150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVX57_RS24160	COG1063	alcohol dehydrogenase
HVX57_RS24165	COG1802	Transcriptional regulator
HVX57_RS24170	COG2271	Major facilitator Superfamily
HVX57_RS24175	COG0456	acetyltransferase
HVX57_RS24185	COG1737	Transcriptional regulator
HVX57_RS24190	COG0800	Aldolase
HVX57_RS24195	COG3734	2-keto-3-deoxy-galactonokinase
HVX57_RS24200	COG4145	pantothenate transmembrane transporter activity
HVX57_RS24210	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVX57_RS24220	COG1846	Transcriptional regulator
HVX57_RS24225	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVX57_RS24235	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS24240	COG3384	dioxygenase
HVX57_RS24250	COG3971	2-oxopent-4-enoate hydratase activity
HVX57_RS24270	COG2368	4-hydroxyphenylacetate
HVX57_RS24275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX57_RS24280	COG1966	Carbon starvation protein
HVX57_RS24285	COG2879	small protein
HVX57_RS24290	COG0523	cobalamin synthesis protein
HVX57_RS24305	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS24310	COG5464	transposase or invertase
HVX57_RS24320	COG1280	lysine exporter protein (LysE YggA)
HVX57_RS24330	COG2733	membrane
HVX57_RS24335	COG2814	Major facilitator Superfamily
HVX57_RS24340	COG1475	DNA binding
HVX57_RS24345	COG3969	phosphoadenosine phosphosulfate
HVX57_RS24355	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVX57_RS24360	COG1924	4 iron, 4 sulfur cluster binding
HVX57_RS24370	COG1473	amidohydrolase
HVX57_RS24375	COG0700	Nucleoside recognition
HVX57_RS24380	COG3366	ferrous iron transmembrane transporter activity
HVX57_RS24385	COG0583	DNA-binding transcription factor activity
HVX57_RS24395	COG1566	PFAM secretion protein HlyD family protein
HVX57_RS24405	COG5457	Domain of unknown function (DUF1127)
HVX57_RS24410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX57_RS24430	COG0732	type I restriction modification DNA specificity domain
HVX57_RS24445	COG0531	amino acid
HVX57_RS24505	COG1454	alcohol dehydrogenase
HVX57_RS24505	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS24520	COG1882	Formate acetyltransferase
HVX57_RS24525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX57_RS24535	COG4869	propanediol catabolic process
HVX57_RS24565	COG0814	amino acid
HVX57_RS24575	COG3706	GGDEF domain
HVX57_RS24580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS24585	COG1129	ABC transporter
HVX57_RS24585	COG0842	Transport permease protein
HVX57_RS24590	COG0842	Transport permease protein
HVX57_RS24620	COG2850	peptidyl-arginine hydroxylation
HVX57_RS24625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HVX57_RS24640	COG0477	Major facilitator Superfamily
HVX57_RS24650	COG0477	Major facilitator Superfamily
HVX57_RS24655	COG4948	Mandelate Racemase Muconate Lactonizing
HVX57_RS24660	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS24665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVX57_RS24740	COG2003	Belongs to the UPF0758 family
HVX57_RS24780	COG2378	regulation of single-species biofilm formation
HVX57_RS24805	COG3436	PFAM IS66 Orf2 family protein
HVX57_RS24810	COG4372	Transposase
HVX57_RS24820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HVX57_RS24870	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX57_RS24875	COG2723	6-phospho-beta-galactosidase activity
HVX57_RS24880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS24885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS24900	COG1609	Transcriptional regulator
HVX57_RS24905	COG5297	Belongs to the glycosyl hydrolase family 6
HVX57_RS24905	COG2273	Hydrolase Family 16
HVX57_RS24910	COG1472	Belongs to the glycosyl hydrolase 3 family
HVX57_RS24930	COG0745	RESPONSE REGULATOR receiver
HVX57_RS24935	COG5002	protein histidine kinase activity
HVX57_RS24980	COG3833	ABC-type maltose transport systems, permease component
HVX57_RS24985	COG1175	transmembrane transport
HVX57_RS24990	COG2182	Extracellular solute-binding protein
HVX57_RS25000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVX57_RS25010	COG3842	ATPase activity
HVX57_RS25035	COG0582	viral genome integration into host DNA
HVX57_RS25055	COG1064	alcohol dehydrogenase
HVX57_RS25060	COG1175	transmembrane transport
HVX57_RS25065	COG0395	ABC-type sugar transport system, permease component
HVX57_RS25070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVX57_RS25075	COG3842	ATPase activity
HVX57_RS25085	COG2814	Major facilitator Superfamily
HVX57_RS25095	COG1082	Xylose isomerase domain protein TIM barrel
HVX57_RS25105	COG3962	Belongs to the TPP enzyme family
HVX57_RS25110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS25115	COG0837	glucose binding
HVX57_RS25115	COG1737	Transcriptional regulator
HVX57_RS25120	COG3718	enzyme involved in inositol metabolism
HVX57_RS25135	COG0433	COG0433 Predicted ATPase
HVX57_RS25140	COG0795	lipopolysaccharide-transporting ATPase activity
HVX57_RS25145	COG0795	lipopolysaccharide-transporting ATPase activity
HVX57_RS25155	COG2927	DNA polymerase III (CHI subunit)
HVX57_RS25160	COG0525	valine-tRNA ligase activity
HVX57_RS25185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVX57_RS25190	COG2731	YhcH YjgK YiaL family protein
HVX57_RS25215	COG3397	chitin binding
HVX57_RS25220	COG0251	oxidation-reduction process
HVX57_RS25235	COG1263	PTS System
HVX57_RS25235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX57_RS25240	COG0366	Alpha amylase catalytic
HVX57_RS25245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX57_RS25250	COG1486	melibiose metabolic process
HVX57_RS25270	COG0602	queuosine metabolic process
HVX57_RS25275	COG3711	transcriptional antiterminator
HVX57_RS25275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX57_RS25280	COG2706	6-phosphogluconolactonase activity
HVX57_RS25295	COG3964	amidohydrolase
HVX57_RS25330	COG0312	modulator of DNA gyrase
HVX57_RS25340	COG1012	belongs to the aldehyde dehydrogenase family
HVX57_RS25360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVX57_RS25370	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS25375	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS25380	COG1129	ABC transporter
HVX57_RS25385	COG1879	ABC-type sugar transport system periplasmic component
HVX57_RS25395	COG2105	PFAM AIG2 family protein
HVX57_RS25400	COG2911	Protein conserved in bacteria
HVX57_RS25405	COG0729	surface antigen
HVX57_RS25415	COG1253	flavin adenine dinucleotide binding
HVX57_RS25440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVX57_RS25455	COG1733	regulation of RNA biosynthetic process
HVX57_RS25460	COG0702	epimerase
HVX57_RS25470	COG0697	spore germination
HVX57_RS25480	COG1113	amino acid transport
HVX57_RS25485	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX57_RS25490	COG3061	Opacity-associated protein A
HVX57_RS25500	COG0359	binds to the 23S rRNA
HVX57_RS25505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVX57_RS25510	COG2965	DNA replication, synthesis of RNA primer
HVX57_RS25570	COG1073	alpha beta
HVX57_RS25575	COG3650	response to hydrogen peroxide
HVX57_RS25585	COG1960	acyl-CoA dehydrogenase activity
HVX57_RS25595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX57_RS25600	COG0557	exoribonuclease II activity
HVX57_RS25615	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVX57_RS25620	COG0330	HflC and HflK could
HVX57_RS25625	COG0330	HflC and HflK could
HVX57_RS25630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVX57_RS25650	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX57_RS25655	COG0802	atpase or kinase
HVX57_RS25660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVX57_RS25660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVX57_RS25665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVX57_RS25685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX57_RS25690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HVX57_RS25705	COG3264	Mechanosensitive ion channel
HVX57_RS25705	COG1511	domain protein
HVX57_RS25720	COG1053	succinate dehydrogenase
HVX57_RS25725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX57_RS25740	COG3040	lipid binding
HVX57_RS25745	COG2076	Multidrug Resistance protein
HVX57_RS25765	COG1509	lysine 2,3-aminomutase activity
HVX57_RS25780	COG3121	Chaperone
HVX57_RS25830	COG0459	protein refolding
HVX57_RS25840	COG0531	amino acid
HVX57_RS25845	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVX57_RS25850	COG1027	Aspartate ammonia-lyase
HVX57_RS25855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX57_RS25870	COG1309	transcriptional regulator
HVX57_RS25885	COG1216	Glycosyl transferase, family 2
HVX57_RS25900	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVX57_RS25915	COG0861	Integral membrane protein TerC family
HVX57_RS25935	COG2824	Alkylphosphonate utilization operon protein PhnA
HVX57_RS25940	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVX57_RS25945	COG2188	Transcriptional regulator
HVX57_RS25950	COG3624	Phosphonate C-P lyase system protein PhnG
HVX57_RS25955	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVX57_RS25960	COG3626	phosphonate metabolism
HVX57_RS25965	COG3627	carbon phosphorus lyase activity
HVX57_RS25970	COG4107	phosphonate C-P lyase system protein PhnK
HVX57_RS25975	COG4778	phosphonate C-P lyase system protein PhnL
HVX57_RS25980	COG3454	Phosphonate metabolism
HVX57_RS25985	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HVX57_RS25990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVX57_RS26000	COG0698	ribose 5-phosphate isomerase
HVX57_RS26005	COG1737	Transcriptional regulator
HVX57_RS26010	COG1879	ABC-type sugar transport system periplasmic component
HVX57_RS26015	COG1129	ABC transporter
HVX57_RS26020	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS26025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX57_RS26030	COG1940	carbohydrate kinase activity
HVX57_RS26040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX57_RS26045	COG1301	dicarboxylic acid transport
HVX57_RS26050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVX57_RS26055	COG3162	membrane
HVX57_RS26080	COG3121	Chaperone
HVX57_RS26090	COG1346	cytolysis
HVX57_RS26095	COG1380	Effector of murein hydrolase LrgA
HVX57_RS26100	COG0583	DNA-binding transcription factor activity
HVX57_RS26105	COG0025	NhaP-type Na H and K H
HVX57_RS26110	COG2252	PERMEase
HVX57_RS26130	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVX57_RS26145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX57_RS26155	COG4771	TonB-dependent receptor
HVX57_RS26160	COG0741	lytic transglycosylase activity
HVX57_RS26165	COG0629	single-stranded DNA binding
HVX57_RS26170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVX57_RS26185	COG2315	Protein conserved in bacteria
HVX57_RS26190	COG0432	Pfam Uncharacterised protein family UPF0047
HVX57_RS26205	COG1448	Aminotransferase
HVX57_RS26210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVX57_RS26215	COG0305	Participates in initiation and elongation during chromosome replication
HVX57_RS26230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX57_RS26240	COG0735	belongs to the Fur family
HVX57_RS26245	COG3237	CsbD-like
HVX57_RS26250	COG0534	Mate efflux family protein
HVX57_RS26260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVX57_RS26330	COG0251	oxidation-reduction process
HVX57_RS26340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HVX57_RS26350	COG0527	aspartate kinase activity
HVX57_RS26355	COG3541	Predicted nucleotidyltransferase
HVX57_RS26365	COG4650	regulator
HVX57_RS26380	COG1187	pseudouridine synthase activity
HVX57_RS26420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVX57_RS26470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVX57_RS26510	COG0151	Belongs to the GarS family
HVX57_RS26520	COG2197	response regulator
HVX57_RS26540	COG3121	Chaperone
HVX57_RS26555	COG1028	Short-chain dehydrogenase reductase Sdr
HVX57_RS26570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX57_RS26585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX57_RS26590	COG1132	(ABC) transporter
HVX57_RS26640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HVX57_RS26655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX57_RS26660	COG2104	thiamine diphosphate biosynthetic process
HVX57_RS26670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVX57_RS26675	COG3706	GGDEF domain
HVX57_RS26685	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX57_RS26690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX57_RS26725	COG0250	Participates in transcription elongation, termination and antitermination
HVX57_RS26730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX57_RS26765	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVX57_RS26765	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVX57_RS26770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVX57_RS26800	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVX57_RS26810	COG1739	Uncharacterized protein family UPF0029
HVX57_RS26855	COG0805	protein transport
HVX57_RS26865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX57_RS26875	COG3165	ubiquinone biosynthetic process from chorismate
HVX57_RS26895	COG0412	Dienelactone hydrolase
HVX57_RS26910	COG0583	DNA-binding transcription factor activity
HVX57_RS26915	COG0697	spore germination
HVX57_RS26920	COG0561	phosphatase activity
HVX57_RS26925	COG2267	carboxylic ester hydrolase activity
HVX57_RS26930	COG1280	lysine exporter protein (LysE YggA)
HVX57_RS26940	COG1280	lysine exporter protein (LysE YggA)
HVX57_RS26955	COG2050	protein possibly involved in aromatic compounds catabolism
HVX57_RS26965	COG0598	Magnesium transport protein CorA
HVX57_RS26970	COG0210	DNA helicase
HVX57_RS26975	COG1011	Hydrolase
HVX57_RS26995	COG5567	small periplasmic lipoprotein
HVX57_RS27005	COG1228	amidohydrolase
HVX57_RS27025	COG3072	Adenylate cyclase
HVX57_RS27035	COG1587	Uroporphyrinogen-III synthase
HVX57_RS27040	COG2959	enzyme of heme biosynthesis
HVX57_RS27045	COG3071	HemY protein
HVX57_RS27090	COG2244	polysaccharide biosynthetic process
HVX57_RS27095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVX57_RS27100	COG0456	acetyltransferase
HVX57_RS27105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVX57_RS27110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVX57_RS27120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVX57_RS27125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVX57_RS27130	COG3118	belongs to the thioredoxin family
HVX57_RS27150	COG1397	ADP-ribosylglycohydrolase
HVX57_RS27185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX57_RS27190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX57_RS27200	COG0583	DNA-binding transcription factor activity
HVX57_RS27205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX57_RS27215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX57_RS27220	COG3978	acetolactate synthase activity
HVX57_RS27240	COG3085	chromosome segregation
HVX57_RS27315	COG0583	DNA-binding transcription factor activity
HVX57_RS27330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVX57_RS27345	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVX57_RS27350	COG2207	Transcriptional regulator
HVX57_RS27360	COG0371	Dehydrogenase
HVX57_RS27365	COG1349	DNA-binding transcription factor activity
HVX57_RS27375	COG0583	DNA-binding transcription factor activity
HVX57_RS27380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX57_RS27385	COG0460	homoserine dehydrogenase
HVX57_RS27385	COG0527	aspartate kinase activity
HVX57_RS27390	COG0626	cystathionine gamma-synthase activity
HVX57_RS27405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVX57_RS27410	COG1609	Transcriptional regulator
HVX57_RS27415	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX57_RS27430	COG1575	Belongs to the MenA family. Type 1 subfamily
HVX57_RS27450	COG3678	ATP-independent chaperone mediated protein folding
HVX57_RS27455	COG0745	RESPONSE REGULATOR receiver
HVX57_RS27460	COG2205	protein histidine kinase activity
HVX57_RS27465	COG2258	MOSC domain
HVX57_RS27510	COG1129	ABC transporter
HVX57_RS27515	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS27525	COG1454	alcohol dehydrogenase
HVX57_RS27545	COG1621	beta-fructofuranosidase activity
HVX57_RS27550	COG2211	Major facilitator Superfamily
HVX57_RS27555	COG1609	Transcriptional regulator
HVX57_RS27570	COG0668	transmembrane transport
HVX57_RS27585	COG3121	Chaperone
HVX57_RS27590	COG3539	Fimbrial protein
HVX57_RS27595	COG3539	Fimbrial protein
HVX57_RS27600	COG3539	Fimbrial protein
HVX57_RS27605	COG3188	usher protein
HVX57_RS27610	COG3121	Chaperone
HVX57_RS27620	COG3539	Fimbrial protein
HVX57_RS27630	COG0110	maltose O-acetyltransferase activity
HVX57_RS27635	COG2211	Major facilitator Superfamily
HVX57_RS27680	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVX57_RS27720	COG0205	6-phosphofructokinase activity
HVX57_RS27740	COG0437	4 iron, 4 sulfur cluster binding
HVX57_RS27745	COG2864	formate dehydrogenase
HVX57_RS27760	COG0456	acetyltransferase
HVX57_RS27765	COG1490	D-aminoacyl-tRNA deacylase activity
HVX57_RS27775	COG1011	Hydrolase
HVX57_RS27790	COG3852	Histidine kinase
HVX57_RS27805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX57_RS27825	COG0204	Acyl-transferase
HVX57_RS27835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVX57_RS27840	COG3084	Protein conserved in bacteria
HVX57_RS27850	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVX57_RS27870	COG2186	Transcriptional regulator
HVX57_RS27875	COG0477	Major facilitator Superfamily
HVX57_RS27880	COG1609	Transcriptional regulator
HVX57_RS27885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX57_RS27895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX57_RS27900	COG1129	ABC transporter
HVX57_RS27930	COG1522	sequence-specific DNA binding
HVX57_RS27935	COG0716	FMN binding
HVX57_RS27950	COG3312	ion transport
HVX57_RS28005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVX57_RS28010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVX57_RS28015	COG0573	inorganic phosphate transmembrane transporter activity
HVX57_RS28020	COG0581	inorganic phosphate transmembrane transporter activity
HVX57_RS28025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVX57_RS28030	COG0704	Plays a role in the regulation of phosphate uptake
HVX57_RS28040	COG2382	esterase
HVX57_RS28045	COG0363	glucosamine-6-phosphate deaminase activity
HVX57_RS28050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX57_RS28055	COG2252	PERMEase
HVX57_RS28060	COG0431	NADPH-dependent FMN reductase
HVX57_RS28065	COG2091	lysine biosynthetic process via aminoadipic acid
HVX57_RS28080	COG2731	YhcH YjgK YiaL family protein
HVX57_RS28100	COG1737	Transcriptional regulator
HVX57_RS28105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVX57_RS28110	COG0456	acetyltransferase
HVX57_RS28170	COG0582	viral genome integration into host DNA
HVX57_RS28185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HVX57_RS28195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HVX57_RS28200	COG1192	Involved in chromosome partitioning
HVX57_RS28285	COG0210	DNA helicase
HVX57_RS28305	COG0210	DNA helicase
HVX57_RS28480	COG3039	Transposase
HVX57_RS28525	COG2223	nitrite transmembrane transporter activity
HVX57_RS28690	COG0786	glutamate:sodium symporter activity
HVX57_RS28705	COG0640	Transcriptional regulator
HVX57_RS28775	COG5001	Diguanylate cyclase
HVX57_RS28775	COG3300	MHYT domain
HVX57_RS28830	COG1695	Transcriptional regulator
HVX57_RS28850	COG3173	Aminoglycoside phosphotransferase
HVX57_RS28925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX57_RS28995	COG0616	signal peptide processing
HVX57_RS29275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVX57_RS29345	COG0445	tRNA wobble uridine modification