locus-tag	class	description
I6K62_RS00020	COG2076	Multidrug Resistance protein
I6K62_RS00040	COG2211	Major facilitator Superfamily
I6K62_RS00045	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K62_RS00050	COG3725	Membrane protein required for beta-lactamase induction
I6K62_RS00065	COG4969	Belongs to the N-Me-Phe pilin family
I6K62_RS00070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K62_RS00075	COG1459	type II secretion system
I6K62_RS00095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6K62_RS00100	COG0494	nUDIX hydrolase
I6K62_RS00120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K62_RS00125	COG0849	cell division
I6K62_RS00150	COG0772	Belongs to the SEDS family
I6K62_RS00165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K62_RS00170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K62_RS00175	COG0768	penicillin binding
I6K62_RS00195	COG1609	Transcriptional regulator
I6K62_RS00205	COG0028	Belongs to the TPP enzyme family
I6K62_RS00220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K62_RS00245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K62_RS00250	COG0738	Major facilitator superfamily
I6K62_RS00260	COG0583	DNA-binding transcription factor activity
I6K62_RS00265	COG2271	Major facilitator Superfamily
I6K62_RS00270	COG2814	Major facilitator Superfamily
I6K62_RS00290	COG1178	ABC-type Fe3 transport system permease component
I6K62_RS00300	COG0586	Pfam SNARE associated Golgi protein
I6K62_RS00320	COG0235	Class ii aldolase
I6K62_RS00325	COG0417	DNA replication proofreading
I6K62_RS00335	COG0564	pseudouridine synthase activity
I6K62_RS00345	COG3493	citrate carrier protein
I6K62_RS00360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K62_RS00415	COG1940	carbohydrate kinase activity
I6K62_RS00490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K62_RS00500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K62_RS00505	COG0471	metal ion transport
I6K62_RS00510	COG0471	metal ion transport
I6K62_RS00515	COG2828	Protein conserved in bacteria
I6K62_RS00520	COG0583	DNA-binding transcription factor activity
I6K62_RS00535	COG1047	Peptidyl-prolyl cis-trans
I6K62_RS00550	COG0196	riboflavin kinase activity
I6K62_RS00560	COG0583	DNA-binding transcription factor activity
I6K62_RS00575	COG3119	arylsulfatase activity
I6K62_RS00590	COG3121	Chaperone
I6K62_RS00595	COG3539	Fimbrial protein
I6K62_RS00600	COG3539	Fimbrial protein
I6K62_RS00610	COG3188	usher protein
I6K62_RS00620	COG3539	Fimbrial protein
I6K62_RS00675	COG4735	regulation of single-species biofilm formation
I6K62_RS00680	COG1584	GPR1 FUN34 yaaH family protein
I6K62_RS00685	COG0477	Major facilitator Superfamily
I6K62_RS00690	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K62_RS00695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K62_RS00700	COG1115	amino acid carrier protein
I6K62_RS00710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K62_RS00720	COG0460	homoserine dehydrogenase
I6K62_RS00720	COG0527	aspartate kinase activity
I6K62_RS00730	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K62_RS00740	COG0745	RESPONSE REGULATOR receiver
I6K62_RS00745	COG4452	Inner membrane protein CreD
I6K62_RS00750	COG2205	protein histidine kinase activity
I6K62_RS00755	COG0745	RESPONSE REGULATOR receiver
I6K62_RS00760	COG3045	CreA protein
I6K62_RS00765	COG2207	Transcriptional regulator
I6K62_RS00765	COG3708	Transcriptional regulator
I6K62_RS00785	COG0741	lytic transglycosylase activity
I6K62_RS00790	COG0488	(ABC) transporter
I6K62_RS00805	COG0560	Phosphoserine phosphatase
I6K62_RS00810	COG3726	membrane protein affecting hemolysin expression
I6K62_RS00820	COG0813	purine-nucleoside phosphorylase activity
I6K62_RS00840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K62_RS00845	COG0084	hydrolase, TatD family'
I6K62_RS00850	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K62_RS00855	COG5487	UPF0391 membrane protein
I6K62_RS00860	COG2823	Periplasmic or secreted lipoprotein
I6K62_RS00870	COG1011	Hydrolase
I6K62_RS00875	COG0456	acetyltransferase
I6K62_RS00880	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K62_RS00910	COG3706	GGDEF domain
I6K62_RS00915	COG4114	ferric iron reductase
I6K62_RS00920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS00925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K62_RS00930	COG2197	response regulator
I6K62_RS00935	COG2197	response regulator
I6K62_RS00940	COG2207	Transcriptional regulator
I6K62_RS00950	COG2966	Psort location CytoplasmicMembrane, score
I6K62_RS00965	COG1484	DNA-dependent DNA replication
I6K62_RS00980	COG5464	transposase or invertase
I6K62_RS00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K62_RS00995	COG3716	PTS system mannose fructose sorbose family IID component
I6K62_RS01000	COG3715	PTS system
I6K62_RS01015	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K62_RS01015	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K62_RS01025	COG1063	alcohol dehydrogenase
I6K62_RS01030	COG1802	Transcriptional regulator
I6K62_RS01035	COG2271	Major facilitator Superfamily
I6K62_RS01040	COG1214	PFAM Peptidase M22, glycoprotease
I6K62_RS01040	COG0456	acetyltransferase
I6K62_RS01050	COG1737	Transcriptional regulator
I6K62_RS01055	COG0800	Aldolase
I6K62_RS01060	COG3734	2-keto-3-deoxy-galactonokinase
I6K62_RS01065	COG4145	pantothenate transmembrane transporter activity
I6K62_RS01075	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K62_RS01085	COG1846	Transcriptional regulator
I6K62_RS01090	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K62_RS01100	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS01105	COG3384	dioxygenase
I6K62_RS01115	COG3971	2-oxopent-4-enoate hydratase activity
I6K62_RS01135	COG2368	4-hydroxyphenylacetate
I6K62_RS01140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K62_RS01155	COG3210	domain, Protein
I6K62_RS01160	COG2831	hemolysin activation secretion protein
I6K62_RS01165	COG1966	Carbon starvation protein
I6K62_RS01170	COG2879	small protein
I6K62_RS01175	COG0523	cobalamin synthesis protein
I6K62_RS01180	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS01185	COG5464	transposase or invertase
I6K62_RS01200	COG0514	ATP-dependent DNA helicase (RecQ)
I6K62_RS01205	COG2733	membrane
I6K62_RS01210	COG2814	Major facilitator Superfamily
I6K62_RS01215	COG1475	DNA binding
I6K62_RS01220	COG3969	phosphoadenosine phosphosulfate
I6K62_RS01230	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K62_RS01235	COG1924	4 iron, 4 sulfur cluster binding
I6K62_RS01245	COG1473	amidohydrolase
I6K62_RS01250	COG0700	Nucleoside recognition
I6K62_RS01255	COG3366	ferrous iron transmembrane transporter activity
I6K62_RS01260	COG0583	DNA-binding transcription factor activity
I6K62_RS01270	COG1566	PFAM secretion protein HlyD family protein
I6K62_RS01280	COG5457	Domain of unknown function (DUF1127)
I6K62_RS01285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K62_RS01305	COG0732	type I restriction modification DNA specificity domain
I6K62_RS01325	COG0531	amino acid
I6K62_RS01340	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K62_RS01375	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS01375	COG1454	alcohol dehydrogenase
I6K62_RS01385	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS01385	COG1454	alcohol dehydrogenase
I6K62_RS01390	COG1882	Formate acetyltransferase
I6K62_RS01395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K62_RS01405	COG4869	propanediol catabolic process
I6K62_RS01435	COG0814	amino acid
I6K62_RS01445	COG3706	GGDEF domain
I6K62_RS01450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS01455	COG0842	Transport permease protein
I6K62_RS01455	COG1129	ABC transporter
I6K62_RS01460	COG0842	Transport permease protein
I6K62_RS01490	COG2850	peptidyl-arginine hydroxylation
I6K62_RS01495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6K62_RS01510	COG0477	Major facilitator Superfamily
I6K62_RS01520	COG0477	Major facilitator Superfamily
I6K62_RS01525	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS01535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K62_RS01590	COG2003	Belongs to the UPF0758 family
I6K62_RS01615	COG2378	regulation of single-species biofilm formation
I6K62_RS01620	COG3596	GTP binding
I6K62_RS01650	COG1201	RNA secondary structure unwinding
I6K62_RS01745	COG0582	viral genome integration into host DNA
I6K62_RS01765	COG1064	alcohol dehydrogenase
I6K62_RS01770	COG1175	transmembrane transport
I6K62_RS01775	COG0395	ABC-type sugar transport system, permease component
I6K62_RS01780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K62_RS01785	COG3842	ATPase activity
I6K62_RS01795	COG2814	Major facilitator Superfamily
I6K62_RS01805	COG1082	Xylose isomerase domain protein TIM barrel
I6K62_RS01815	COG3962	Belongs to the TPP enzyme family
I6K62_RS01820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS01825	COG1737	Transcriptional regulator
I6K62_RS01825	COG0837	glucose binding
I6K62_RS01830	COG3718	enzyme involved in inositol metabolism
I6K62_RS01845	COG0433	COG0433 Predicted ATPase
I6K62_RS01850	COG0795	lipopolysaccharide-transporting ATPase activity
I6K62_RS01855	COG0795	lipopolysaccharide-transporting ATPase activity
I6K62_RS01865	COG2927	DNA polymerase III (CHI subunit)
I6K62_RS01870	COG0525	valine-tRNA ligase activity
I6K62_RS01895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K62_RS01900	COG2188	Transcriptional regulator
I6K62_RS01905	COG1288	antiporter activity
I6K62_RS01910	COG1228	amidohydrolase
I6K62_RS01915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS01920	COG2222	sugar isomerase
I6K62_RS01925	COG2731	YhcH YjgK YiaL family protein
I6K62_RS01945	COG3397	chitin binding
I6K62_RS01950	COG0251	oxidation-reduction process
I6K62_RS01965	COG1609	Transcriptional regulator
I6K62_RS01970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS01970	COG1263	PTS System
I6K62_RS01975	COG0366	Alpha amylase catalytic
I6K62_RS01980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS01985	COG1486	melibiose metabolic process
I6K62_RS02005	COG0602	queuosine metabolic process
I6K62_RS02015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS02015	COG3711	transcriptional antiterminator
I6K62_RS02020	COG2706	6-phosphogluconolactonase activity
I6K62_RS02035	COG3964	amidohydrolase
I6K62_RS02070	COG0312	modulator of DNA gyrase
I6K62_RS02080	COG1454	alcohol dehydrogenase
I6K62_RS02080	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS02085	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS02105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K62_RS02125	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS02130	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS02135	COG1129	ABC transporter
I6K62_RS02140	COG1879	ABC-type sugar transport system periplasmic component
I6K62_RS02150	COG2105	PFAM AIG2 family protein
I6K62_RS02155	COG2911	Protein conserved in bacteria
I6K62_RS02160	COG0729	surface antigen
I6K62_RS02170	COG1253	flavin adenine dinucleotide binding
I6K62_RS02180	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K62_RS02195	COG1733	regulation of RNA biosynthetic process
I6K62_RS02200	COG0702	epimerase
I6K62_RS02210	COG0697	spore germination
I6K62_RS02220	COG1113	amino acid transport
I6K62_RS02225	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K62_RS02230	COG3061	Opacity-associated protein A
I6K62_RS02240	COG0359	binds to the 23S rRNA
I6K62_RS02245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K62_RS02250	COG2965	DNA replication, synthesis of RNA primer
I6K62_RS02310	COG1073	alpha beta
I6K62_RS02315	COG3650	response to hydrogen peroxide
I6K62_RS02325	COG1960	acyl-CoA dehydrogenase activity
I6K62_RS02335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K62_RS02340	COG0557	exoribonuclease II activity
I6K62_RS02355	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K62_RS02360	COG0330	HflC and HflK could
I6K62_RS02365	COG0330	HflC and HflK could
I6K62_RS02370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K62_RS02390	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K62_RS02395	COG0802	atpase or kinase
I6K62_RS02400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K62_RS02400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K62_RS02405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K62_RS02425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS02430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6K62_RS02445	COG3264	Mechanosensitive ion channel
I6K62_RS02445	COG1511	domain protein
I6K62_RS02455	COG1053	succinate dehydrogenase
I6K62_RS02460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K62_RS02475	COG3040	lipid binding
I6K62_RS02480	COG2076	Multidrug Resistance protein
I6K62_RS02485	COG5510	response to toxic substance
I6K62_RS02500	COG1509	lysine 2,3-aminomutase activity
I6K62_RS02515	COG3121	Chaperone
I6K62_RS02555	COG0459	protein refolding
I6K62_RS02565	COG0531	amino acid
I6K62_RS02570	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K62_RS02575	COG1027	Aspartate ammonia-lyase
I6K62_RS02580	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K62_RS02595	COG1309	transcriptional regulator
I6K62_RS02610	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K62_RS02625	COG0861	Integral membrane protein TerC family
I6K62_RS02645	COG2169	Transcriptional regulator
I6K62_RS02655	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K62_RS02660	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K62_RS02665	COG2188	Transcriptional regulator
I6K62_RS02670	COG3624	Phosphonate C-P lyase system protein PhnG
I6K62_RS02675	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K62_RS02680	COG3626	phosphonate metabolism
I6K62_RS02685	COG3627	carbon phosphorus lyase activity
I6K62_RS02690	COG4107	phosphonate C-P lyase system protein PhnK
I6K62_RS02695	COG4778	phosphonate C-P lyase system protein PhnL
I6K62_RS02700	COG3454	Phosphonate metabolism
I6K62_RS02710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K62_RS02740	COG0698	ribose 5-phosphate isomerase
I6K62_RS02745	COG1737	Transcriptional regulator
I6K62_RS02750	COG1879	ABC-type sugar transport system periplasmic component
I6K62_RS02755	COG1129	ABC transporter
I6K62_RS02760	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS02765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K62_RS02770	COG1940	carbohydrate kinase activity
I6K62_RS02780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K62_RS02785	COG1301	dicarboxylic acid transport
I6K62_RS02790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K62_RS02795	COG3162	membrane
I6K62_RS02840	COG0583	DNA-binding transcription factor activity
I6K62_RS02845	COG0025	NhaP-type Na H and K H
I6K62_RS02850	COG2252	PERMEase
I6K62_RS02870	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K62_RS02885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K62_RS02895	COG4771	TonB-dependent receptor
I6K62_RS02900	COG0741	lytic transglycosylase activity
I6K62_RS02905	COG0629	single-stranded DNA binding
I6K62_RS02925	COG2315	Protein conserved in bacteria
I6K62_RS02930	COG0432	Pfam Uncharacterised protein family UPF0047
I6K62_RS02940	COG1448	Aminotransferase
I6K62_RS02950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K62_RS02955	COG0305	Participates in initiation and elongation during chromosome replication
I6K62_RS02970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K62_RS02980	COG0735	belongs to the Fur family
I6K62_RS02985	COG3237	CsbD-like
I6K62_RS02990	COG0534	Mate efflux family protein
I6K62_RS03000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K62_RS03050	COG2814	Major facilitator Superfamily
I6K62_RS03050	COG0477	Major facilitator Superfamily
I6K62_RS03085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K62_RS03095	COG0527	aspartate kinase activity
I6K62_RS03100	COG3541	Predicted nucleotidyltransferase
I6K62_RS03105	COG0330	HflC and HflK could
I6K62_RS03115	COG4650	regulator
I6K62_RS03130	COG1187	pseudouridine synthase activity
I6K62_RS03170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K62_RS03210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K62_RS03250	COG0151	Belongs to the GarS family
I6K62_RS03260	COG4191	Histidine kinase
I6K62_RS03300	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K62_RS03315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K62_RS03320	COG2104	thiamine diphosphate biosynthetic process
I6K62_RS03330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K62_RS03335	COG3706	GGDEF domain
I6K62_RS03345	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K62_RS03350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K62_RS03385	COG0250	Participates in transcription elongation, termination and antitermination
I6K62_RS03390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K62_RS03430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K62_RS03460	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K62_RS03470	COG1739	Uncharacterized protein family UPF0029
I6K62_RS03515	COG0805	protein transport
I6K62_RS03535	COG3165	ubiquinone biosynthetic process from chorismate
I6K62_RS03565	COG0641	radical SAM
I6K62_RS03570	COG2188	Transcriptional regulator
I6K62_RS03575	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6K62_RS03580	COG1263	PTS System
I6K62_RS03580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS03590	COG0583	DNA-binding transcription factor activity
I6K62_RS03595	COG0697	spore germination
I6K62_RS03600	COG0561	phosphatase activity
I6K62_RS03605	COG2267	carboxylic ester hydrolase activity
I6K62_RS03610	COG1280	lysine exporter protein (LysE YggA)
I6K62_RS03620	COG1280	lysine exporter protein (LysE YggA)
I6K62_RS03635	COG2050	protein possibly involved in aromatic compounds catabolism
I6K62_RS03645	COG0598	Magnesium transport protein CorA
I6K62_RS03650	COG0210	DNA helicase
I6K62_RS03655	COG1011	Hydrolase
I6K62_RS03675	COG5567	small periplasmic lipoprotein
I6K62_RS03685	COG3072	Adenylate cyclase
I6K62_RS03695	COG1587	Uroporphyrinogen-III synthase
I6K62_RS03700	COG2959	enzyme of heme biosynthesis
I6K62_RS03705	COG3071	HemY protein
I6K62_RS03750	COG2244	polysaccharide biosynthetic process
I6K62_RS03755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K62_RS03760	COG0456	acetyltransferase
I6K62_RS03765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K62_RS03770	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K62_RS03775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K62_RS03780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K62_RS03790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K62_RS03795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K62_RS03800	COG3118	belongs to the thioredoxin family
I6K62_RS03815	COG0583	DNA-binding transcription factor activity
I6K62_RS03825	COG1811	Na channel or pump
I6K62_RS03835	COG1397	ADP-ribosylglycohydrolase
I6K62_RS03845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS03870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K62_RS03875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K62_RS03895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K62_RS03905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K62_RS03910	COG3978	acetolactate synthase activity
I6K62_RS03930	COG3085	chromosome segregation
I6K62_RS04005	COG0583	DNA-binding transcription factor activity
I6K62_RS04020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K62_RS04035	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K62_RS04045	COG2207	Transcriptional regulator
I6K62_RS04055	COG0371	Dehydrogenase
I6K62_RS04060	COG1349	DNA-binding transcription factor activity
I6K62_RS04065	COG0697	spore germination
I6K62_RS04075	COG0583	DNA-binding transcription factor activity
I6K62_RS04095	COG0527	aspartate kinase activity
I6K62_RS04095	COG0460	homoserine dehydrogenase
I6K62_RS04100	COG0626	cystathionine gamma-synthase activity
I6K62_RS04110	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K62_RS04125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K62_RS04130	COG1609	Transcriptional regulator
I6K62_RS04135	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K62_RS04150	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K62_RS04170	COG3678	ATP-independent chaperone mediated protein folding
I6K62_RS04175	COG0745	RESPONSE REGULATOR receiver
I6K62_RS04180	COG2205	protein histidine kinase activity
I6K62_RS04185	COG2258	MOSC domain
I6K62_RS04190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K62_RS04230	COG1129	ABC transporter
I6K62_RS04235	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS04245	COG1454	alcohol dehydrogenase
I6K62_RS04260	COG2211	Major facilitator Superfamily
I6K62_RS04265	COG1609	Transcriptional regulator
I6K62_RS04275	COG0110	maltose O-acetyltransferase activity
I6K62_RS04280	COG2211	Major facilitator Superfamily
I6K62_RS04300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K62_RS04345	COG0205	6-phosphofructokinase activity
I6K62_RS04365	COG0437	4 iron, 4 sulfur cluster binding
I6K62_RS04370	COG2864	formate dehydrogenase
I6K62_RS04385	COG0657	acetylesterase activity
I6K62_RS04390	COG0456	acetyltransferase
I6K62_RS04395	COG1490	D-aminoacyl-tRNA deacylase activity
I6K62_RS04405	COG1011	Hydrolase
I6K62_RS04420	COG3852	Histidine kinase
I6K62_RS04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K62_RS04455	COG0204	Acyl-transferase
I6K62_RS04465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K62_RS04470	COG3084	Protein conserved in bacteria
I6K62_RS04475	COG0746	molybdenum cofactor guanylyltransferase activity
I6K62_RS04480	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K62_RS04500	COG2186	Transcriptional regulator
I6K62_RS04505	COG0477	Major facilitator Superfamily
I6K62_RS04510	COG1609	Transcriptional regulator
I6K62_RS04515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS04525	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS04530	COG1129	ABC transporter
I6K62_RS04560	COG1522	sequence-specific DNA binding
I6K62_RS04565	COG0716	FMN binding
I6K62_RS04580	COG3312	ion transport
I6K62_RS04640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K62_RS04645	COG0573	inorganic phosphate transmembrane transporter activity
I6K62_RS04650	COG0581	inorganic phosphate transmembrane transporter activity
I6K62_RS04655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K62_RS04660	COG0704	Plays a role in the regulation of phosphate uptake
I6K62_RS04670	COG2382	esterase
I6K62_RS04675	COG0363	glucosamine-6-phosphate deaminase activity
I6K62_RS04680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS04685	COG2252	PERMEase
I6K62_RS04690	COG0431	NADPH-dependent FMN reductase
I6K62_RS04695	COG2091	lysine biosynthetic process via aminoadipic acid
I6K62_RS04710	COG2731	YhcH YjgK YiaL family protein
I6K62_RS04730	COG1737	Transcriptional regulator
I6K62_RS04735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K62_RS04755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K62_RS04765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6K62_RS04775	COG0592	DNA-directed DNA polymerase activity
I6K62_RS04785	COG0187	DNA topoisomerase II activity
I6K62_RS04790	COG0583	DNA-binding transcription factor activity
I6K62_RS04800	COG0561	phosphatase activity
I6K62_RS04805	COG2186	Transcriptional regulator
I6K62_RS04810	COG3734	2-keto-3-deoxy-galactonokinase
I6K62_RS04815	COG0800	Aldolase
I6K62_RS04825	COG2271	Major facilitator Superfamily
I6K62_RS04830	COG0823	Involved in the tonB-independent uptake of proteins
I6K62_RS04835	COG5645	(Lipo)protein
I6K62_RS04855	COG2188	Transcriptional regulator
I6K62_RS04870	COG2207	Transcriptional regulator
I6K62_RS04875	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K62_RS04880	COG3119	arylsulfatase activity
I6K62_RS04885	COG2149	membrane
I6K62_RS04895	COG0641	radical SAM
I6K62_RS04905	COG2610	gluconate transmembrane transporter activity
I6K62_RS04910	COG0583	DNA-binding transcription factor activity
I6K62_RS04915	COG2814	Major facilitator Superfamily
I6K62_RS04940	COG0028	Belongs to the TPP enzyme family
I6K62_RS04945	COG0440	acetolactate synthase activity
I6K62_RS04950	COG2197	response regulator
I6K62_RS04960	COG2271	Major facilitator Superfamily
I6K62_RS05000	COG2188	Transcriptional regulator
I6K62_RS05025	COG4580	involved in the transport of maltose and maltodextrins
I6K62_RS05030	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K62_RS05035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS05035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS05045	COG1609	Transcriptional regulator
I6K62_RS05055	COG5464	transposase or invertase
I6K62_RS05060	COG0697	spore germination
I6K62_RS05065	COG1263	PTS System
I6K62_RS05065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS05075	COG2814	Major facilitator Superfamily
I6K62_RS05085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K62_RS05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS05100	COG1309	transcriptional regulator
I6K62_RS05110	COG0583	DNA-binding transcription factor activity
I6K62_RS05125	COG1464	Belongs to the NlpA lipoprotein family
I6K62_RS05140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K62_RS05150	COG1064	alcohol dehydrogenase
I6K62_RS05170	COG3311	Transcriptional regulator
I6K62_RS05185	COG2211	Major facilitator Superfamily
I6K62_RS05190	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K62_RS05200	COG1486	melibiose metabolic process
I6K62_RS05205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS05205	COG1263	PTS System
I6K62_RS05210	COG2982	Protein involved in outer membrane biogenesis
I6K62_RS05215	COG2233	PERMEase
I6K62_RS05220	COG0786	glutamate:sodium symporter activity
I6K62_RS05235	COG3074	FtsZ-dependent cytokinesis
I6K62_RS05250	COG2211	Major facilitator Superfamily
I6K62_RS05255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS05265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K62_RS05285	COG3152	Membrane
I6K62_RS05295	COG1494	fructose-1,6-bisphosphatase
I6K62_RS05300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K62_RS05305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K62_RS05310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K62_RS05330	COG2860	membrane
I6K62_RS05340	COG1561	YicC-like family, N-terminal region
I6K62_RS05350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6K62_RS05370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K62_RS05380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6K62_RS05385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6K62_RS05405	COG1519	Transferase
I6K62_RS05410	COG1216	Glycosyl transferase, family 2
I6K62_RS05415	COG0438	transferase activity, transferring glycosyl groups
I6K62_RS05425	COG0859	PFAM glycosyl transferase family 9
I6K62_RS05450	COG0859	PFAM glycosyl transferase family 9
I6K62_RS05455	COG0859	PFAM glycosyl transferase family 9
I6K62_RS05465	COG0156	8-amino-7-oxononanoate synthase activity
I6K62_RS05475	COG0463	Glycosyl transferase, family 2
I6K62_RS05480	COG2861	carbohydrate metabolic process
I6K62_RS05485	COG4942	peptidase
I6K62_RS05495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K62_RS05500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K62_RS05520	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K62_RS05530	COG2186	Transcriptional regulator
I6K62_RS05550	COG3722	fumarate hydratase activity
I6K62_RS05575	COG0625	glutathione transferase activity
I6K62_RS05585	COG3276	selenocysteine insertion sequence binding
I6K62_RS05600	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS05605	COG3977	Valine--pyruvate aminotransferase
I6K62_RS05610	COG0366	Alpha amylase catalytic
I6K62_RS05615	COG2992	FlgJ-related protein
I6K62_RS05620	COG1609	Transcriptional regulator
I6K62_RS05620	COG2207	Transcriptional regulator
I6K62_RS05625	COG4214	carbohydrate transport
I6K62_RS05635	COG4213	ABC transporter substrate-binding protein
I6K62_RS05640	COG2115	Belongs to the xylose isomerase family
I6K62_RS05645	COG1070	Carbohydrate kinase
I6K62_RS05650	COG4682	membrane
I6K62_RS05655	COG3274	enterobacterial common antigen metabolic process
I6K62_RS05685	COG1278	Cold shock
I6K62_RS05690	COG2944	sequence-specific DNA binding
I6K62_RS05695	COG2814	Major facilitator Superfamily
I6K62_RS05715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS05725	COG1609	Transcriptional regulator
I6K62_RS05730	COG2885	chlorophyll binding
I6K62_RS05735	COG0243	molybdopterin cofactor binding
I6K62_RS05740	COG0456	acetyltransferase
I6K62_RS05745	COG2818	Glycosylase
I6K62_RS05750	COG5571	outer membrane autotransporter
I6K62_RS05755	COG2223	nitrite transmembrane transporter activity
I6K62_RS05770	COG0747	negative chemotaxis
I6K62_RS05775	COG0601	transmembrane transport
I6K62_RS05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K62_RS05785	COG0444	Belongs to the ABC transporter superfamily
I6K62_RS05790	COG4608	Belongs to the ABC transporter superfamily
I6K62_RS05800	COG0489	protein tyrosine kinase activity
I6K62_RS05815	COG0457	Tetratricopeptide repeat
I6K62_RS05845	COG2194	sulfuric ester hydrolase activity
I6K62_RS05875	COG1215	transferase activity, transferring glycosyl groups
I6K62_RS05885	COG0457	Tetratricopeptide repeat
I6K62_RS05885	COG3118	belongs to the thioredoxin family
I6K62_RS05890	COG2200	EAL domain
I6K62_RS05890	COG2199	diguanylate cyclase activity
I6K62_RS05900	COG0612	Peptidase, M16
I6K62_RS05910	COG2982	Protein involved in outer membrane biogenesis
I6K62_RS05915	COG0477	Major facilitator Superfamily
I6K62_RS05920	COG1295	ribonuclease BN
I6K62_RS05925	COG0583	DNA-binding transcription factor activity
I6K62_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS05935	COG2197	response regulator
I6K62_RS05945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K62_RS05965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K62_RS05970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K62_RS05985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K62_RS05990	COG2183	response to ionizing radiation
I6K62_RS05995	COG1918	ferrous iron import across plasma membrane
I6K62_RS06020	COG1040	competence protein
I6K62_RS06030	COG2610	gluconate transmembrane transporter activity
I6K62_RS06050	COG0589	response to stress
I6K62_RS06060	COG0306	phosphate transporter
I6K62_RS06065	COG2081	HI0933 family
I6K62_RS06070	COG2204	response regulator
I6K62_RS06075	COG3964	amidohydrolase
I6K62_RS06080	COG0471	metal ion transport
I6K62_RS06085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K62_RS06090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K62_RS06100	COG2239	Acts as a magnesium transporter
I6K62_RS06120	COG0444	Belongs to the ABC transporter superfamily
I6K62_RS06125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K62_RS06130	COG0601	transmembrane transport
I6K62_RS06135	COG0747	negative chemotaxis
I6K62_RS06145	COG3479	Phenolic acid decarboxylase
I6K62_RS06185	COG0628	permease
I6K62_RS06190	COG0477	Major facilitator Superfamily
I6K62_RS06200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K62_RS06215	COG3714	YhhN family
I6K62_RS06225	COG3776	membrane
I6K62_RS06230	COG0742	ribosomal rna small subunit methyltransferase
I6K62_RS06235	COG0552	protein localization to endoplasmic reticulum
I6K62_RS06240	COG2884	Cell division ATP-binding protein ftsE
I6K62_RS06245	COG2177	Part of the ABC transporter FtsEX involved in
I6K62_RS06260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K62_RS06270	COG0683	leucine binding
I6K62_RS06280	COG0683	leucine binding
I6K62_RS06305	COG2721	sulfolactate sulfo-lyase activity
I6K62_RS06310	COG2271	Major facilitator Superfamily
I6K62_RS06315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K62_RS06320	COG1414	Transcriptional regulator
I6K62_RS06345	COG0584	glycerophosphoryl diester phosphodiesterase
I6K62_RS06355	COG0405	Gamma-glutamyltransferase
I6K62_RS06360	COG1247	-acetyltransferase
I6K62_RS06370	COG0673	inositol 2-dehydrogenase activity
I6K62_RS06375	COG1741	Belongs to the pirin family
I6K62_RS06380	COG1609	Transcriptional regulator
I6K62_RS06385	COG3265	gluconokinase activity
I6K62_RS06390	COG2610	gluconate transmembrane transporter activity
I6K62_RS06395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K62_RS06420	COG0058	SHG alpha-glucan phosphorylase activity
I6K62_RS06425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K62_RS06440	COG1349	DNA-binding transcription factor activity
I6K62_RS06445	COG4650	regulator
I6K62_RS06450	COG1690	Belongs to the RtcB family
I6K62_RS06465	COG0058	SHG alpha-glucan phosphorylase activity
I6K62_RS06470	COG1640	4-alpha-glucanotransferase
I6K62_RS06485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K62_RS06490	COG1011	Hydrolase
I6K62_RS06500	COG0494	nUDIX hydrolase
I6K62_RS06505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K62_RS06530	COG4796	Type ii and iii secretion system protein
I6K62_RS06545	COG3266	domain, Protein
I6K62_RS06550	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K62_RS06555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K62_RS06585	COG2146	nitrite reductase [NAD(P)H] activity
I6K62_RS06590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K62_RS06595	COG0402	S-adenosylhomocysteine deaminase activity
I6K62_RS06600	COG0738	Major facilitator superfamily
I6K62_RS06625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K62_RS06630	COG1289	transmembrane transporter activity
I6K62_RS06640	COG1765	OsmC-like protein
I6K62_RS06645	COG3954	Phosphoribulokinase
I6K62_RS06655	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K62_RS06660	COG0488	(ABC) transporter
I6K62_RS06675	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K62_RS06680	COG1047	Peptidyl-prolyl cis-trans
I6K62_RS06690	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K62_RS06695	COG2964	Protein conserved in bacteria
I6K62_RS06750	COG0051	transcription antitermination factor activity, RNA binding
I6K62_RS06760	COG0088	Forms part of the polypeptide exit tunnel
I6K62_RS06775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K62_RS06790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K62_RS06840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6K62_RS06855	COG0201	protein transport
I6K62_RS06870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6K62_RS06880	COG0202	RNA polymerase activity
I6K62_RS06885	COG0203	ribosomal protein L17
I6K62_RS06895	COG0789	Transcriptional regulator
I6K62_RS06900	COG3036	rescue of stalled ribosome
I6K62_RS06930	COG0758	DNA mediated transformation
I6K62_RS06940	COG0551	DNA topoisomerase type I activity
I6K62_RS06960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K62_RS07000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K62_RS07005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS07010	COG1309	transcriptional regulator
I6K62_RS07035	COG4145	pantothenate transmembrane transporter activity
I6K62_RS07040	COG3924	membrane
I6K62_RS07045	COG0439	Biotin carboxylase
I6K62_RS07050	COG0511	ligase activity, forming carbon-carbon bonds
I6K62_RS07065	COG0604	alcohol dehydrogenase
I6K62_RS07070	COG2200	EAL domain
I6K62_RS07070	COG2199	diguanylate cyclase activity
I6K62_RS07075	COG1077	Cell shape determining protein MreB Mrl
I6K62_RS07080	COG1792	Involved in formation and maintenance of cell shape
I6K62_RS07085	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K62_RS07095	COG1530	ribonuclease E activity
I6K62_RS07100	COG3164	Protein of unknown function
I6K62_RS07105	COG0312	modulator of DNA gyrase
I6K62_RS07110	COG1349	DNA-binding transcription factor activity
I6K62_RS07115	COG0583	DNA-binding transcription factor activity
I6K62_RS07130	COG1289	transmembrane transporter activity
I6K62_RS07135	COG2732	(Barnase) inhibitor
I6K62_RS07160	COG1802	Transcriptional regulator
I6K62_RS07170	COG0471	metal ion transport
I6K62_RS07175	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS07180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS07190	COG0511	ligase activity, forming carbon-carbon bonds
I6K62_RS07190	COG5016	pyruvate
I6K62_RS07205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K62_RS07210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K62_RS07215	COG3105	Protein conserved in bacteria
I6K62_RS07220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K62_RS07235	COG0625	glutathione transferase activity
I6K62_RS07240	COG2969	positive regulation of protein catabolic process
I6K62_RS07245	COG3539	Fimbrial protein
I6K62_RS07250	COG3121	Chaperone
I6K62_RS07255	COG3188	usher protein
I6K62_RS07265	COG3539	Fimbrial protein
I6K62_RS07270	COG0493	'glutamate synthase
I6K62_RS07275	COG0067	glutamate synthase
I6K62_RS07275	COG0069	glutamate synthase activity
I6K62_RS07275	COG0070	glutamate synthase
I6K62_RS07280	COG1242	4 iron, 4 sulfur cluster binding
I6K62_RS07285	COG1312	Catalyzes the dehydration of D-mannonate
I6K62_RS07290	COG0784	Response regulator, receiver
I6K62_RS07290	COG5002	protein histidine kinase activity
I6K62_RS07290	COG2198	Histidine kinase
I6K62_RS07295	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K62_RS07300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K62_RS07305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS07310	COG1660	Displays ATPase and GTPase activities
I6K62_RS07315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS07320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K62_RS07325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K62_RS07330	COG1137	ATPase activity
I6K62_RS07335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K62_RS07340	COG3117	lipopolysaccharide transmembrane transporter activity
I6K62_RS07345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K62_RS07355	COG0530	calcium, potassium:sodium antiporter activity
I6K62_RS07360	COG1127	ABC transporter
I6K62_RS07365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K62_RS07370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K62_RS07375	COG2854	intermembrane phospholipid transfer
I6K62_RS07380	COG3113	response to antibiotic
I6K62_RS07385	COG5007	Belongs to the BolA IbaG family
I6K62_RS07395	COG3423	Transcriptional regulator
I6K62_RS07400	COG0142	geranyltranstransferase activity
I6K62_RS07415	COG0697	spore germination
I6K62_RS07425	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K62_RS07430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K62_RS07435	COG1534	Rna-binding protein
I6K62_RS07445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K62_RS07450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K62_RS07460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K62_RS07485	COG0195	Participates in both transcription termination and antitermination
I6K62_RS07490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6K62_RS07525	COG0513	Belongs to the DEAD box helicase family
I6K62_RS07530	COG0814	amino acid
I6K62_RS07555	COG4770	biotin carboxylase activity
I6K62_RS07605	COG3034	peptidoglycan biosynthetic process
I6K62_RS07610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K62_RS07615	COG0826	peptidase U32
I6K62_RS07620	COG0826	peptidase U32
I6K62_RS07625	COG3154	lipid carrier protein
I6K62_RS07630	COG3153	acetyltransferase
I6K62_RS07635	COG2827	Endonuclease containing a URI domain
I6K62_RS07645	COG0693	protein deglycase activity
I6K62_RS07650	COG0702	epimerase
I6K62_RS07655	COG0701	Predicted permease
I6K62_RS07660	COG2823	Periplasmic or secreted lipoprotein
I6K62_RS07680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K62_RS07685	COG3539	Fimbrial protein
I6K62_RS07690	COG3188	usher protein
I6K62_RS07695	COG3121	Chaperone
I6K62_RS07700	COG3539	Fimbrial protein
I6K62_RS07710	COG1063	alcohol dehydrogenase
I6K62_RS07715	COG3775	system Galactitol-specific IIC component
I6K62_RS07720	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K62_RS07725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS07730	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
I6K62_RS07735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS07735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS07740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS07740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS07740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS07755	COG1349	DNA-binding transcription factor activity
I6K62_RS07760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS07765	COG2721	sulfolactate sulfo-lyase activity
I6K62_RS07770	COG2271	Major facilitator Superfamily
I6K62_RS07780	COG2084	Dehydrogenase
I6K62_RS07785	COG1929	Belongs to the glycerate kinase type-1 family
I6K62_RS07810	COG1741	Belongs to the pirin family
I6K62_RS07815	COG0583	DNA-binding transcription factor activity
I6K62_RS07820	COG3152	Membrane
I6K62_RS07825	COG0435	Glutathione S-transferase
I6K62_RS07830	COG2259	Doxx family
I6K62_RS07840	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K62_RS07845	COG4575	ribosome binding
I6K62_RS07850	COG1422	Protein of unknown function (DUF1090)
I6K62_RS07860	COG0586	Pfam SNARE associated Golgi protein
I6K62_RS07865	COG2186	Transcriptional regulator
I6K62_RS07870	COG2271	Major facilitator Superfamily
I6K62_RS07880	COG2721	sulfolactate sulfo-lyase activity
I6K62_RS07900	COG0673	inositol 2-dehydrogenase activity
I6K62_RS07905	COG1451	nucleotide metabolic process
I6K62_RS07910	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K62_RS07920	COG2211	Major facilitator Superfamily
I6K62_RS07935	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K62_RS07935	COG1902	pentaerythritol trinitrate reductase activity
I6K62_RS07955	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS07980	COG3408	Glycogen debranching enzyme
I6K62_RS07980	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K62_RS07990	COG0531	amino acid
I6K62_RS07995	COG0531	amino acid
I6K62_RS08000	COG2731	YhcH YjgK YiaL family protein
I6K62_RS08005	COG3250	beta-galactosidase activity
I6K62_RS08010	COG1609	Transcriptional regulator
I6K62_RS08015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K62_RS08025	COG1695	Transcriptional regulator
I6K62_RS08030	COG2375	cellular response to nickel ion
I6K62_RS08045	COG1461	Dihydroxyacetone kinase
I6K62_RS08050	COG2376	Dihydroxyacetone kinase
I6K62_RS08090	COG4974	Belongs to the 'phage' integrase family
I6K62_RS08155	COG4695	Portal protein
I6K62_RS08335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K62_RS08390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K62_RS08405	COG4991	sh3 domain protein
I6K62_RS08410	COG3025	triphosphatase activity
I6K62_RS08430	COG2960	long-chain fatty acid transporting porin activity
I6K62_RS08445	COG3384	dioxygenase
I6K62_RS08450	COG0754	glutathionylspermidine amidase activity
I6K62_RS08465	COG0494	nUDIX hydrolase
I6K62_RS08470	COG3151	Protein conserved in bacteria
I6K62_RS08475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K62_RS08480	COG3150	esterase
I6K62_RS08485	COG0187	DNA topoisomerase II activity
I6K62_RS08490	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K62_RS08495	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K62_RS08500	COG0642	Histidine kinase
I6K62_RS08510	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K62_RS08520	COG0204	Acyl-transferase
I6K62_RS08525	COG2132	Multicopper oxidase
I6K62_RS08530	COG1032	radical SAM domain protein
I6K62_RS08545	COG1979	alcohol dehydrogenase
I6K62_RS08550	COG2207	Transcriptional regulator
I6K62_RS08555	COG0586	Pfam SNARE associated Golgi protein
I6K62_RS08570	COG0848	biopolymer transport protein
I6K62_RS08575	COG2211	Major facilitator Superfamily
I6K62_RS08600	COG0625	glutathione transferase activity
I6K62_RS08610	COG0754	glutathionylspermidine amidase activity
I6K62_RS08615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K62_RS08635	COG0583	DNA-binding transcription factor activity
I6K62_RS08640	COG0626	cystathionine gamma-synthase activity
I6K62_RS08655	COG0471	metal ion transport
I6K62_RS08665	COG3188	usher protein
I6K62_RS08690	COG3710	Transcriptional regulator
I6K62_RS08725	COG1811	Na channel or pump
I6K62_RS08730	COG1982	Orn Lys Arg decarboxylase major
I6K62_RS08735	COG2211	Major facilitator Superfamily
I6K62_RS08750	COG1194	a g-specific adenine glycosylase
I6K62_RS08760	COG3171	Protein conserved in bacteria
I6K62_RS08780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K62_RS08785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K62_RS08790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K62_RS08805	COG0762	integral membrane protein
I6K62_RS08810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K62_RS08815	COG2805	Type II/IV secretion system protein
I6K62_RS08820	COG2197	response regulator
I6K62_RS08835	COG0189	ligase activity
I6K62_RS08840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K62_RS08845	COG2356	endonuclease I
I6K62_RS08855	COG2814	Major facilitator Superfamily
I6K62_RS08875	COG1166	arginine decarboxylase activity
I6K62_RS08890	COG2146	nitrite reductase [NAD(P)H] activity
I6K62_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS08910	COG1414	Transcriptional regulator
I6K62_RS08925	COG2814	Major facilitator Superfamily
I6K62_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS08945	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K62_RS08960	COG0501	Belongs to the peptidase M48B family
I6K62_RS08965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K62_RS08970	COG1122	ATPase activity
I6K62_RS08975	COG1122	ATPase activity
I6K62_RS09005	COG0191	fructose-bisphosphate aldolase activity
I6K62_RS09010	COG0668	transmembrane transport
I6K62_RS09015	COG1279	arginine transmembrane transporter activity
I6K62_RS09020	COG2968	Membrane
I6K62_RS09025	COG0583	DNA-binding transcription factor activity
I6K62_RS09030	COG0427	acetyl-CoA hydrolase
I6K62_RS09035	COG1024	Enoyl-CoA hydratase
I6K62_RS09040	COG1703	isobutyryl-CoA mutase activity
I6K62_RS09045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K62_RS09045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K62_RS09060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K62_RS09065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K62_RS09085	COG0006	proline dipeptidase activity
I6K62_RS09090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K62_RS09095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K62_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS09120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K62_RS09125	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS09130	COG1737	Transcriptional regulator
I6K62_RS09140	COG1272	protein, Hemolysin III
I6K62_RS09150	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K62_RS09160	COG0716	FMN binding
I6K62_RS09175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K62_RS09195	COG1811	Na channel or pump
I6K62_RS09205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K62_RS09210	COG0583	DNA-binding transcription factor activity
I6K62_RS09215	COG4942	peptidase
I6K62_RS09225	COG4974	Belongs to the 'phage' integrase family
I6K62_RS09270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS09275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS09275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS09275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K62_RS09280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS09285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K62_RS09295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS09300	COG2207	Transcriptional regulator
I6K62_RS09305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS09310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS09310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS09310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K62_RS09315	COG0667	Aldo Keto reductase
I6K62_RS09320	COG0656	L-ascorbic acid biosynthetic process
I6K62_RS09325	COG1280	lysine exporter protein (LysE YggA)
I6K62_RS09335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K62_RS09340	COG2213	PTS system mannitol-specific
I6K62_RS09340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS09345	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K62_RS09350	COG3775	system Galactitol-specific IIC component
I6K62_RS09355	COG0698	ribose 5-phosphate isomerase
I6K62_RS09360	COG1349	DNA-binding transcription factor activity
I6K62_RS09365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS09370	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K62_RS09375	COG3775	system Galactitol-specific IIC component
I6K62_RS09380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K62_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS09390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K62_RS09420	COG2200	EAL domain
I6K62_RS09435	COG3539	Fimbrial protein
I6K62_RS09440	COG3121	Chaperone
I6K62_RS09465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K62_RS09485	COG2046	Belongs to the sulfate adenylyltransferase family
I6K62_RS09485	COG0529	Catalyzes the synthesis of activated sulfate
I6K62_RS09495	COG2223	nitrite transmembrane transporter activity
I6K62_RS09500	COG3835	regulator
I6K62_RS09505	COG1929	Belongs to the glycerate kinase type-1 family
I6K62_RS09550	COG0738	Major facilitator superfamily
I6K62_RS09555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS09560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K62_RS09565	COG1349	DNA-binding transcription factor activity
I6K62_RS09585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS09595	COG1538	Outer membrane efflux protein
I6K62_RS09600	COG1289	transmembrane transporter activity
I6K62_RS09615	COG3592	Divergent 4Fe-4S mono-cluster
I6K62_RS09620	COG2388	GCN5-related N-acetyl-transferase
I6K62_RS09630	COG3539	Fimbrial protein
I6K62_RS09635	COG3539	Fimbrial protein
I6K62_RS09640	COG3539	Fimbrial protein
I6K62_RS09645	COG3188	usher protein
I6K62_RS09650	COG3121	Chaperone
I6K62_RS09655	COG3539	Fimbrial protein
I6K62_RS09665	COG4974	Belongs to the 'phage' integrase family
I6K62_RS09670	COG0582	viral genome integration into host DNA
I6K62_RS09680	COG1522	sequence-specific DNA binding
I6K62_RS09685	COG1846	Transcriptional regulator
I6K62_RS09690	COG0697	spore germination
I6K62_RS09705	COG0640	Transcriptional regulator
I6K62_RS09750	COG0667	Aldo Keto reductase
I6K62_RS09755	COG0814	amino acid
I6K62_RS09770	COG0183	Belongs to the thiolase family
I6K62_RS09780	COG0823	Involved in the tonB-independent uptake of proteins
I6K62_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS09790	COG2814	Major facilitator Superfamily
I6K62_RS09815	COG0823	Involved in the tonB-independent uptake of proteins
I6K62_RS09825	COG3842	ATPase activity
I6K62_RS09830	COG0395	ABC-type sugar transport system, permease component
I6K62_RS09835	COG1175	transmembrane transport
I6K62_RS09845	COG1794	racemase activity, acting on amino acids and derivatives
I6K62_RS09850	COG0583	DNA-binding transcription factor activity
I6K62_RS09860	COG1609	Transcriptional regulator
I6K62_RS09865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS09870	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS09875	COG2186	Transcriptional regulator
I6K62_RS09885	COG1609	Transcriptional regulator
I6K62_RS09900	COG0667	Aldo Keto reductase
I6K62_RS09910	COG0861	Integral membrane protein TerC family
I6K62_RS09945	COG2165	general secretion pathway protein
I6K62_RS09950	COG4795	General secretion pathway protein
I6K62_RS09960	COG4967	type IV pilus modification protein PilV
I6K62_RS09965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K62_RS09970	COG1025	Belongs to the peptidase M16 family
I6K62_RS09975	COG1074	ATP-dependent DNA helicase activity
I6K62_RS09980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K62_RS09985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K62_RS09985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K62_RS09990	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K62_RS09995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K62_RS10025	COG4656	Part of a membrane complex involved in electron transport
I6K62_RS10030	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS10030	COG1454	alcohol dehydrogenase
I6K62_RS10045	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K62_RS10060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K62_RS10225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K62_RS10230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K62_RS10235	COG2166	iron-sulfur cluster assembly
I6K62_RS10240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K62_RS10250	COG0583	DNA-binding transcription factor activity
I6K62_RS10255	COG2363	Small membrane protein
I6K62_RS10265	COG1349	DNA-binding transcription factor activity
I6K62_RS10285	COG0738	Major facilitator superfamily
I6K62_RS10290	COG0235	Class ii aldolase
I6K62_RS10305	COG3829	transcription factor binding
I6K62_RS10310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K62_RS10325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K62_RS10330	COG1760	l-serine dehydratase
I6K62_RS10335	COG0814	amino acid
I6K62_RS10340	COG1611	Belongs to the LOG family
I6K62_RS10355	COG3098	single-species biofilm formation
I6K62_RS10360	COG0564	pseudouridine synthase activity
I6K62_RS10365	COG0716	FMN binding
I6K62_RS10370	COG2271	Major facilitator Superfamily
I6K62_RS10375	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS10380	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS10385	COG1929	Belongs to the glycerate kinase type-1 family
I6K62_RS10390	COG3850	Histidine kinase
I6K62_RS10390	COG3437	response regulator, receiver
I6K62_RS10390	COG4999	Histidine kinase
I6K62_RS10390	COG2205	protein histidine kinase activity
I6K62_RS10400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K62_RS10410	COG3956	TIGRFAM MazG family protein
I6K62_RS10430	COG0602	queuosine metabolic process
I6K62_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS10440	COG0720	synthase
I6K62_RS10485	COG2234	aminopeptidase activity
I6K62_RS10545	COG4942	peptidase
I6K62_RS10545	COG1388	LysM domain
I6K62_RS10550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K62_RS10560	COG0477	Major facilitator Superfamily
I6K62_RS10580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K62_RS10600	COG3539	Fimbrial protein
I6K62_RS10610	COG3188	usher protein
I6K62_RS10615	COG3121	Chaperone
I6K62_RS10625	COG3539	Fimbrial protein
I6K62_RS10630	COG3539	Fimbrial protein
I6K62_RS10655	COG1132	(ABC) transporter
I6K62_RS10660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS10670	COG1538	Outer membrane efflux protein
I6K62_RS10675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K62_RS10715	COG1454	alcohol dehydrogenase
I6K62_RS10720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6K62_RS10725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS10730	COG4558	Periplasmic binding protein
I6K62_RS10735	COG3720	iron ion transport
I6K62_RS10755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K62_RS10760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K62_RS10765	COG1121	(ABC) transporter
I6K62_RS10775	COG1609	Transcriptional regulator
I6K62_RS10780	COG1940	carbohydrate kinase activity
I6K62_RS10785	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K62_RS10790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS10795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS10800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS10805	COG4580	involved in the transport of maltose and maltodextrins
I6K62_RS10815	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS10820	COG2755	lipolytic protein G-D-S-L family
I6K62_RS10820	COG0657	acetylesterase activity
I6K62_RS10830	COG0309	Hydrogenase expression formation protein (HypE)
I6K62_RS10835	COG0409	Hydrogenase expression formation protein
I6K62_RS10840	COG0298	carbon dioxide binding
I6K62_RS10845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K62_RS10860	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS10865	COG0651	ATP synthesis coupled electron transport
I6K62_RS10870	COG0650	Formate hydrogenlyase subunit 4
I6K62_RS10875	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K62_RS10875	COG3261	NADH dehydrogenase
I6K62_RS10880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K62_RS10885	COG3260	NADH ubiquinone oxidoreductase 20
I6K62_RS10895	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K62_RS10900	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS10905	COG1263	PTS System
I6K62_RS10905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS10910	COG1609	Transcriptional regulator
I6K62_RS10915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS10920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K62_RS10925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K62_RS10950	COG1349	DNA-binding transcription factor activity
I6K62_RS10955	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS10970	COG3732	PTS system glucitol sorbitol-specific
I6K62_RS10975	COG3730	PTS system glucitol sorbitol-specific
I6K62_RS10980	COG2951	lytic endotransglycosylase activity
I6K62_RS10990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K62_RS10995	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K62_RS11005	COG1546	Belongs to the CinA family
I6K62_RS11025	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K62_RS11055	COG2823	Periplasmic or secreted lipoprotein
I6K62_RS11060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS11065	COG1238	metal cluster binding
I6K62_RS11085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K62_RS11090	COG2814	Major facilitator Superfamily
I6K62_RS11095	COG1566	PFAM secretion protein HlyD family protein
I6K62_RS11100	COG1846	Transcriptional regulator
I6K62_RS11110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K62_RS11120	COG4176	ABC-type proline glycine betaine transport system permease component
I6K62_RS11135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K62_RS11145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K62_RS11150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K62_RS11160	COG4575	ribosome binding
I6K62_RS11185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K62_RS11190	COG0640	Transcriptional regulator
I6K62_RS11195	COG3284	Transcriptional regulator
I6K62_RS11210	COG3121	Chaperone
I6K62_RS11215	COG3188	usher protein
I6K62_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS11245	COG2814	Major facilitator Superfamily
I6K62_RS11250	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS11260	COG0235	Class ii aldolase
I6K62_RS11265	COG1126	abc transporter atp-binding protein
I6K62_RS11270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS11305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS11305	COG2190	(PTS) system
I6K62_RS11305	COG1263	PTS System
I6K62_RS11330	COG4974	Belongs to the 'phage' integrase family
I6K62_RS11405	COG0582	viral genome integration into host DNA
I6K62_RS11420	COG2867	negative regulation of translational initiation
I6K62_RS11435	COG0497	DNA recombination
I6K62_RS11450	COG4536	flavin adenine dinucleotide binding
I6K62_RS11455	COG4137	Cytochrome C assembly protein
I6K62_RS11460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K62_RS11495	COG2885	chlorophyll binding
I6K62_RS11500	COG2199	diguanylate cyclase activity
I6K62_RS11510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K62_RS11515	COG1605	Chorismate mutase
I6K62_RS11515	COG0287	Prephenate dehydrogenase
I6K62_RS11525	COG1605	Chorismate mutase
I6K62_RS11525	COG0077	Prephenate dehydratase
I6K62_RS11535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K62_RS11540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K62_RS11555	COG0542	response to heat
I6K62_RS11585	COG0477	Major facilitator Superfamily
I6K62_RS11590	COG5544	Lipoprotein
I6K62_RS11595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K62_RS11605	COG3148	PFAM DTW domain containing protein
I6K62_RS11610	COG3118	belongs to the thioredoxin family
I6K62_RS11615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K62_RS11630	COG0513	Belongs to the DEAD box helicase family
I6K62_RS11640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K62_RS11655	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K62_RS11660	COG3026	antisigma factor binding
I6K62_RS11665	COG3086	response to oxidative stress
I6K62_RS11675	COG0681	Belongs to the peptidase S26 family
I6K62_RS11695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K62_RS11705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS11710	COG0583	DNA-binding transcription factor activity
I6K62_RS11715	COG2223	nitrite transmembrane transporter activity
I6K62_RS11720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K62_RS11725	COG1737	Transcriptional regulator
I6K62_RS11730	COG0560	Phosphoserine phosphatase
I6K62_RS11745	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K62_RS11745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K62_RS11750	COG2205	protein histidine kinase activity
I6K62_RS11755	COG3170	Tfp pilus assembly protein FimV
I6K62_RS11760	COG2204	response regulator
I6K62_RS11765	COG0347	Belongs to the P(II) protein family
I6K62_RS11770	COG1017	nitric oxide dioxygenase activity
I6K62_RS11770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K62_RS11780	COG2259	Doxx family
I6K62_RS11785	COG1940	carbohydrate kinase activity
I6K62_RS11790	COG0457	Tetratricopeptide repeat
I6K62_RS11800	COG2017	converts alpha-aldose to the beta-anomer
I6K62_RS11805	COG2814	Major facilitator Superfamily
I6K62_RS11810	COG3711	transcriptional antiterminator
I6K62_RS11815	COG3683	transport system, periplasmic component
I6K62_RS11820	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K62_RS11845	COG0822	iron-sulfur transferase activity
I6K62_RS11865	COG0633	Ferredoxin
I6K62_RS11870	COG2975	iron-sulfur cluster assembly
I6K62_RS11885	COG2897	thiosulfate sulfurtransferase activity
I6K62_RS11890	COG1473	amidohydrolase
I6K62_RS11900	COG2373	Large extracellular alpha-helical protein
I6K62_RS11905	COG4953	penicillin-binding protein 1C
I6K62_RS11935	COG2976	Protein conserved in bacteria
I6K62_RS11950	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K62_RS11960	COG1645	bacterial-type flagellum-dependent swarming motility
I6K62_RS11975	COG1570	exodeoxyribonuclease VII activity
I6K62_RS11980	COG0517	IMP dehydrogenase activity
I6K62_RS11980	COG0516	GMP reductase activity
I6K62_RS11985	COG0519	Catalyzes the synthesis of GMP from XMP
I6K62_RS11985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K62_RS11990	COG3121	Chaperone
I6K62_RS12015	COG3121	Chaperone
I6K62_RS12055	COG0583	DNA-binding transcription factor activity
I6K62_RS12060	COG0583	DNA-binding transcription factor activity
I6K62_RS12080	COG2200	EAL domain
I6K62_RS12095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K62_RS12110	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS12125	COG2233	PERMEase
I6K62_RS12135	COG1393	Belongs to the ArsC family
I6K62_RS12140	COG4783	chaperone-mediated protein folding
I6K62_RS12145	COG0628	permease
I6K62_RS12150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K62_RS12155	COG2716	regulation of RNA biosynthetic process
I6K62_RS12165	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K62_RS12175	COG2321	neutral zinc metallopeptidase
I6K62_RS12185	COG0400	carboxylic ester hydrolase activity
I6K62_RS12200	COG1393	Belongs to the ArsC family
I6K62_RS12210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K62_RS12215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS12215	COG0493	'glutamate synthase
I6K62_RS12225	COG5342	invasion associated locus B
I6K62_RS12230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K62_RS12240	COG4810	utilization protein
I6K62_RS12320	COG2207	Transcriptional regulator
I6K62_RS12330	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K62_RS12350	COG2837	iron assimilation
I6K62_RS12355	COG4150	thiosulfate binding
I6K62_RS12360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K62_RS12365	COG4208	sulfate ABC transporter
I6K62_RS12370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K62_RS12380	COG4319	ketosteroid isomerase
I6K62_RS12420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K62_RS12440	COG3530	Putative quorum-sensing-regulated virulence factor
I6K62_RS12445	COG0385	Bile acid
I6K62_RS12450	COG0583	DNA-binding transcription factor activity
I6K62_RS12455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6K62_RS12460	COG2211	Major facilitator Superfamily
I6K62_RS12465	COG0583	DNA-binding transcription factor activity
I6K62_RS12495	COG3415	Transposase
I6K62_RS12500	COG3415	Transposase
I6K62_RS12515	COG2200	EAL domain
I6K62_RS12515	COG2199	diguanylate cyclase activity
I6K62_RS12520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K62_RS12535	COG0667	Aldo Keto reductase
I6K62_RS12540	COG3961	Belongs to the TPP enzyme family
I6K62_RS12555	COG3279	Response regulator of the LytR AlgR family
I6K62_RS12560	COG3275	phosphorelay sensor kinase activity
I6K62_RS12565	COG0436	Aminotransferase
I6K62_RS12575	COG2807	transmembrane transport
I6K62_RS12580	COG0583	DNA-binding transcription factor activity
I6K62_RS12595	COG2116	formate transmembrane transporter activity
I6K62_RS12610	COG3691	Protein conserved in bacteria
I6K62_RS12625	COG2062	phosphohistidine phosphatase, SixA
I6K62_RS12650	COG0730	response to heat
I6K62_RS12655	COG3101	peptidyl-lysine hydroxylation
I6K62_RS12670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K62_RS12690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K62_RS12700	COG0586	Pfam SNARE associated Golgi protein
I6K62_RS12710	COG0285	dihydrofolate synthase activity
I6K62_RS12715	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K62_RS12720	COG1286	toxin biosynthetic process
I6K62_RS12725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K62_RS12735	COG2211	Major facilitator Superfamily
I6K62_RS12740	COG1940	carbohydrate kinase activity
I6K62_RS12745	COG1609	Transcriptional regulator
I6K62_RS12750	COG0163	prenyltransferase activity
I6K62_RS12770	COG4160	amino acid transport
I6K62_RS12775	COG4598	ABC transporter
I6K62_RS12795	COG1090	epimerase
I6K62_RS12800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K62_RS12805	COG0625	glutathione transferase activity
I6K62_RS12810	COG0625	glutathione transferase activity
I6K62_RS12815	COG0622	Phosphoesterase
I6K62_RS12825	COG1609	Transcriptional regulator
I6K62_RS12830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS12840	COG3037	sugar-specific permease SgaT UlaA
I6K62_RS12845	COG3959	Transketolase, thiamine diphosphate binding domain
I6K62_RS12850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6K62_RS12875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS12880	COG0490	domain, Protein
I6K62_RS12880	COG0471	metal ion transport
I6K62_RS12890	COG0436	Aminotransferase
I6K62_RS12895	COG0583	DNA-binding transcription factor activity
I6K62_RS12945	COG0839	Belongs to the complex I subunit 6 family
I6K62_RS12950	COG0713	ATP synthesis coupled electron transport
I6K62_RS12955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K62_RS12960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K62_RS12970	COG0582	viral genome integration into host DNA
I6K62_RS13000	COG0582	viral genome integration into host DNA
I6K62_RS13010	COG2153	protein acetylation
I6K62_RS13015	COG1169	isochorismate synthase
I6K62_RS13045	COG3647	Membrane
I6K62_RS13100	COG1414	Transcriptional regulator
I6K62_RS13110	COG2271	Major facilitator Superfamily
I6K62_RS13120	COG0247	lactate metabolic process
I6K62_RS13130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K62_RS13135	COG2271	Major facilitator Superfamily
I6K62_RS13140	COG0584	glycerophosphoryl diester phosphodiesterase
I6K62_RS13145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K62_RS13170	COG2205	protein histidine kinase activity
I6K62_RS13170	COG0784	Response regulator, receiver
I6K62_RS13180	COG2198	Histidine kinase
I6K62_RS13180	COG0642	Histidine kinase
I6K62_RS13195	COG2169	Transcriptional regulator
I6K62_RS13195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K62_RS13200	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K62_RS13205	COG4615	Cyclic peptide transporter
I6K62_RS13210	COG2239	Acts as a magnesium transporter
I6K62_RS13215	COG0659	secondary active sulfate transmembrane transporter activity
I6K62_RS13230	COG0628	permease
I6K62_RS13285	COG1349	DNA-binding transcription factor activity
I6K62_RS13290	COG0494	nUDIX hydrolase
I6K62_RS13300	COG1061	Type III restriction enzyme res subunit
I6K62_RS13305	COG1187	pseudouridine synthase activity
I6K62_RS13310	COG2814	Major facilitator Superfamily
I6K62_RS13320	COG4172	Belongs to the ABC transporter superfamily
I6K62_RS13325	COG4239	(ABC) transporter, permease
I6K62_RS13330	COG4174	ABC transporter (Permease)
I6K62_RS13335	COG4166	transmembrane transport
I6K62_RS13340	COG2200	EAL domain
I6K62_RS13345	COG0791	NLP P60 protein
I6K62_RS13350	COG0671	phosphoesterase, PA-phosphatase related
I6K62_RS13355	COG0523	cobalamin synthesis protein
I6K62_RS13360	COG0246	Mannitol dehydrogenase
I6K62_RS13365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6K62_RS13450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K62_RS13465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS13465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS13470	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K62_RS13475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS13475	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K62_RS13475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS13480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS13485	COG2313	pseudouridylate synthase activity
I6K62_RS13490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K62_RS13495	COG1522	sequence-specific DNA binding
I6K62_RS13495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS13505	COG2855	membrane
I6K62_RS13510	COG0583	DNA-binding transcription factor activity
I6K62_RS13525	COG0833	amino acid
I6K62_RS13530	COG4771	TonB-dependent receptor
I6K62_RS13545	COG2311	Membrane
I6K62_RS13560	COG1129	ABC transporter
I6K62_RS13570	COG2949	membrane
I6K62_RS13580	COG1346	cytolysis
I6K62_RS13590	COG0583	DNA-binding transcription factor activity
I6K62_RS13595	COG2271	Major facilitator Superfamily
I6K62_RS13610	COG0625	glutathione transferase activity
I6K62_RS13615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K62_RS13620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K62_RS13625	COG3711	transcriptional antiterminator
I6K62_RS13635	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS13640	COG2226	methyltransferase
I6K62_RS13645	COG1538	Outer membrane efflux protein
I6K62_RS13650	COG0586	Pfam SNARE associated Golgi protein
I6K62_RS13660	COG1686	Belongs to the peptidase S11 family
I6K62_RS13670	COG0277	FAD linked oxidase domain protein
I6K62_RS13675	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K62_RS13680	COG1732	Glycine betaine
I6K62_RS13685	COG1174	glycine betaine transport
I6K62_RS13690	COG1125	glycine betaine transport
I6K62_RS13695	COG1174	glycine betaine transport
I6K62_RS13705	COG0789	Transcriptional regulator
I6K62_RS13710	COG3275	phosphorelay sensor kinase activity
I6K62_RS13720	COG4807	Protein conserved in bacteria
I6K62_RS13725	COG4808	Protein conserved in bacteria
I6K62_RS13730	COG4715	Zinc finger, swim domain protein
I6K62_RS13735	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6K62_RS13740	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K62_RS13745	COG0714	Associated with various cellular activities
I6K62_RS13750	COG3831	ATPase activity
I6K62_RS13755	COG3831	ATPase activity
I6K62_RS13760	COG3831	ATPase activity
I6K62_RS13780	COG5455	response to cobalt ion
I6K62_RS13785	COG0583	DNA-binding transcription factor activity
I6K62_RS13795	COG2252	PERMEase
I6K62_RS13805	COG0583	DNA-binding transcription factor activity
I6K62_RS13815	COG0351	phosphomethylpyrimidine kinase
I6K62_RS13820	COG1830	Aldolase
I6K62_RS13825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K62_RS13850	COG1070	Carbohydrate kinase
I6K62_RS13860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS13865	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS13870	COG0747	negative chemotaxis
I6K62_RS13875	COG0601	transmembrane transport
I6K62_RS13880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K62_RS13885	COG0444	Belongs to the ABC transporter superfamily
I6K62_RS13890	COG4608	Belongs to the ABC transporter superfamily
I6K62_RS13910	COG0826	peptidase U32
I6K62_RS13930	COG0745	RESPONSE REGULATOR receiver
I6K62_RS13935	COG2205	protein histidine kinase activity
I6K62_RS13965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS13970	COG4215	(ABC) transporter
I6K62_RS13980	COG1522	sequence-specific DNA binding
I6K62_RS13990	COG1301	dicarboxylic acid transport
I6K62_RS14010	COG5002	protein histidine kinase activity
I6K62_RS14015	COG0372	Belongs to the citrate synthase family
I6K62_RS14205	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K62_RS14220	COG2982	Protein involved in outer membrane biogenesis
I6K62_RS14225	COG1253	flavin adenine dinucleotide binding
I6K62_RS14275	COG0110	maltose O-acetyltransferase activity
I6K62_RS14305	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K62_RS14315	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6K62_RS14365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K62_RS14375	COG0438	transferase activity, transferring glycosyl groups
I6K62_RS14400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K62_RS14415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K62_RS14430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K62_RS14435	COG0583	DNA-binding transcription factor activity
I6K62_RS14445	COG0531	amino acid
I6K62_RS14450	COG0640	Transcriptional regulator
I6K62_RS14455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K62_RS14460	COG2925	Exonuclease
I6K62_RS14480	COG1289	transmembrane transporter activity
I6K62_RS14500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K62_RS14510	COG2814	Major facilitator Superfamily
I6K62_RS14515	COG0673	inositol 2-dehydrogenase activity
I6K62_RS14520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS14520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS14525	COG1082	Xylose isomerase domain protein TIM barrel
I6K62_RS14535	COG1942	4-Oxalocrotonate Tautomerase
I6K62_RS14540	COG0583	DNA-binding transcription factor activity
I6K62_RS14545	COG0095	Lipoate-protein ligase
I6K62_RS14550	COG0477	Major facilitator Superfamily
I6K62_RS14560	COG5001	Diguanylate cyclase
I6K62_RS14560	COG3300	MHYT domain
I6K62_RS14565	COG3615	Tellurite resistance protein tehB
I6K62_RS14575	COG2188	Transcriptional regulator
I6K62_RS14580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS14580	COG1263	PTS System
I6K62_RS14595	COG3539	Fimbrial protein
I6K62_RS14600	COG3539	Fimbrial protein
I6K62_RS14605	COG3539	Fimbrial protein
I6K62_RS14610	COG3188	usher protein
I6K62_RS14615	COG3121	Chaperone
I6K62_RS14620	COG3539	Fimbrial protein
I6K62_RS14660	COG1376	ErfK ybiS ycfS ynhG family protein
I6K62_RS14675	COG2814	Major facilitator Superfamily
I6K62_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS14740	COG0534	Mate efflux family protein
I6K62_RS14750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K62_RS14780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K62_RS14790	COG0589	response to stress
I6K62_RS14800	COG2819	hydrolase of the alpha beta superfamily
I6K62_RS14830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K62_RS14840	COG1418	mRNA catabolic process
I6K62_RS14845	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K62_RS14850	COG2721	sulfolactate sulfo-lyase activity
I6K62_RS14855	COG2271	Major facilitator Superfamily
I6K62_RS14865	COG2084	Dehydrogenase
I6K62_RS14875	COG0129	dihydroxy-acid dehydratase activity
I6K62_RS14880	COG2186	Transcriptional regulator
I6K62_RS14890	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS14900	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS14905	COG2271	Major facilitator Superfamily
I6K62_RS14915	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS14925	COG3727	T/G mismatch-specific endonuclease activity
I6K62_RS14930	COG0697	spore germination
I6K62_RS14935	COG2354	Protein conserved in bacteria
I6K62_RS14940	COG5475	Uncharacterized small protein (DUF2158)
I6K62_RS14970	COG0366	Alpha amylase catalytic
I6K62_RS14975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS14985	COG0765	amino acid transport
I6K62_RS14990	COG1126	abc transporter atp-binding protein
I6K62_RS14995	COG2197	response regulator
I6K62_RS15005	COG2197	response regulator
I6K62_RS15035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K62_RS15040	COG3318	Belongs to the UPF0149 family
I6K62_RS15040	COG3012	SEC-C Motif Domain Protein
I6K62_RS15045	COG0814	amino acid
I6K62_RS15055	COG1528	Iron-storage protein
I6K62_RS15065	COG0477	Major facilitator Superfamily
I6K62_RS15085	COG1528	Iron-storage protein
I6K62_RS15095	COG1879	ABC-type sugar transport system periplasmic component
I6K62_RS15105	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS15130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K62_RS15135	COG0018	arginyl-trna synthetase
I6K62_RS15140	COG3102	Protein conserved in bacteria
I6K62_RS15160	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K62_RS15165	COG1801	Protein of unknown function DUF72
I6K62_RS15170	COG1335	isochorismatase
I6K62_RS15180	COG0494	nUDIX hydrolase
I6K62_RS15185	COG0217	transcriptional regulatory protein
I6K62_RS15210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K62_RS15220	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K62_RS15225	COG0739	heme binding
I6K62_RS15230	COG1560	Kdo2-lipid A biosynthetic process
I6K62_RS15240	COG1737	Transcriptional regulator
I6K62_RS15245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K62_RS15250	COG0129	dihydroxy-acid dehydratase activity
I6K62_RS15255	COG0800	Aldolase
I6K62_RS15265	COG3141	response to X-ray
I6K62_RS15270	COG2979	Protein of unknown function (DUF533)
I6K62_RS15275	COG1770	oligopeptidase
I6K62_RS15280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K62_RS15290	COG2372	response to copper ion
I6K62_RS15295	COG1276	copper resistance
I6K62_RS15335	COG2990	Protein conserved in bacteria
I6K62_RS15360	COG3008	intermembrane lipid transfer
I6K62_RS15365	COG2995	paraquat-inducible protein a
I6K62_RS15370	COG1956	GAF domain-containing protein
I6K62_RS15390	COG2814	Major facilitator Superfamily
I6K62_RS15395	COG1414	Transcriptional regulator
I6K62_RS15425	COG0768	penicillin binding
I6K62_RS15430	COG2226	methyltransferase
I6K62_RS15445	COG3716	PTS system mannose fructose sorbose family IID component
I6K62_RS15450	COG3715	PTS system
I6K62_RS15455	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS15455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS15460	COG1253	flavin adenine dinucleotide binding
I6K62_RS15465	COG2200	EAL domain
I6K62_RS15470	COG1760	l-serine dehydratase
I6K62_RS15500	COG1653	transport
I6K62_RS15505	COG1175	transmembrane transport
I6K62_RS15510	COG0395	ABC-type sugar transport system, permease component
I6K62_RS15515	COG3842	ATPase activity
I6K62_RS15525	COG0251	oxidation-reduction process
I6K62_RS15530	COG1199	ATP-dependent helicase activity
I6K62_RS15535	COG1214	PFAM Peptidase M22, glycoprotease
I6K62_RS15540	COG3065	identical protein binding
I6K62_RS15550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K62_RS15560	COG2894	cell division
I6K62_RS15575	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K62_RS15605	COG2719	SpoVR family
I6K62_RS15625	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K62_RS15635	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K62_RS15640	COG2211	Major facilitator Superfamily
I6K62_RS15650	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K62_RS15655	COG2308	Evidence 4 Homologs of previously reported genes of
I6K62_RS15680	COG2814	Major facilitator Superfamily
I6K62_RS15700	COG0583	DNA-binding transcription factor activity
I6K62_RS15705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6K62_RS15725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS15725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS15730	COG2814	Major facilitator Superfamily
I6K62_RS15745	COG2068	MobA-Related Protein
I6K62_RS15755	COG2233	PERMEase
I6K62_RS15760	COG0493	'glutamate synthase
I6K62_RS15760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS15765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS15770	COG0402	S-adenosylhomocysteine deaminase activity
I6K62_RS15775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K62_RS15775	COG0493	'glutamate synthase
I6K62_RS15780	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K62_RS15780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K62_RS15785	COG0549	Belongs to the carbamate kinase family
I6K62_RS15795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K62_RS15800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K62_RS15805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K62_RS15810	COG3829	transcription factor binding
I6K62_RS15815	COG0012	GTP binding
I6K62_RS15835	COG0659	secondary active sulfate transmembrane transporter activity
I6K62_RS15865	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K62_RS15885	COG0387	Pfam Sodium calcium exchanger
I6K62_RS15890	COG4572	Cation transport regulator
I6K62_RS15895	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K62_RS15905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K62_RS15910	COG3707	response regulator
I6K62_RS15915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K62_RS15925	COG1116	anion transmembrane transporter activity
I6K62_RS15930	COG2146	nitrite reductase [NAD(P)H] activity
I6K62_RS15930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K62_RS15935	COG0243	molybdopterin cofactor binding
I6K62_RS15940	COG4932	domain protein
I6K62_RS15945	COG2197	response regulator
I6K62_RS15950	COG3850	Histidine kinase
I6K62_RS15955	COG2223	nitrite transmembrane transporter activity
I6K62_RS15960	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K62_RS15965	COG1140	nitrate reductase beta subunit
I6K62_RS15970	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K62_RS15975	COG2181	nitrate reductase activity
I6K62_RS15995	COG0788	formyltetrahydrofolate deformylase activity
I6K62_RS16005	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K62_RS16010	COG0745	RESPONSE REGULATOR receiver
I6K62_RS16015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K62_RS16035	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS16035	COG1454	alcohol dehydrogenase
I6K62_RS16040	COG2095	MarC family integral membrane protein
I6K62_RS16050	COG0601	transmembrane transport
I6K62_RS16055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K62_RS16060	COG0444	Belongs to the ABC transporter superfamily
I6K62_RS16070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K62_RS16090	COG1902	pentaerythritol trinitrate reductase activity
I6K62_RS16095	COG2350	Protein conserved in bacteria
I6K62_RS16145	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K62_RS16150	COG3001	Fructosamine kinase
I6K62_RS16160	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K62_RS16165	COG3137	Salt-induced outer membrane protein
I6K62_RS16190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6K62_RS16210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K62_RS16210	COG0072	phenylalanine-tRNA ligase activity
I6K62_RS16230	COG0386	Belongs to the glutathione peroxidase family
I6K62_RS16240	COG0791	NLP P60 protein
I6K62_RS16250	COG4256	Hemin uptake protein
I6K62_RS16255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K62_RS16265	COG0574	Belongs to the PEP-utilizing enzyme family
I6K62_RS16265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K62_RS16275	COG0628	permease
I6K62_RS16280	COG0247	lactate metabolic process
I6K62_RS16280	COG0277	FAD linked oxidase domain protein
I6K62_RS16285	COG2050	protein possibly involved in aromatic compounds catabolism
I6K62_RS16290	COG2261	transglycosylase associated protein
I6K62_RS16305	COG0316	Belongs to the HesB IscA family
I6K62_RS16310	COG0719	Fe-S assembly protein
I6K62_RS16315	COG0396	ATPase activity
I6K62_RS16320	COG0719	Fe-S assembly protein
I6K62_RS16335	COG1376	ErfK ybiS ycfS ynhG family protein
I6K62_RS16360	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K62_RS16360	COG1082	Xylose isomerase domain protein TIM barrel
I6K62_RS16365	COG2271	Major facilitator Superfamily
I6K62_RS16370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K62_RS16380	COG1120	ATPase activity
I6K62_RS16385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS16390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K62_RS16395	COG1414	Transcriptional regulator
I6K62_RS16430	COG2814	Major facilitator Superfamily
I6K62_RS16460	COG0583	DNA-binding transcription factor activity
I6K62_RS16465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K62_RS16470	COG1960	acyl-CoA dehydrogenase activity
I6K62_RS16485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K62_RS16490	COG1116	anion transmembrane transporter activity
I6K62_RS16495	COG4774	siderophore transport
I6K62_RS16500	COG1120	ATPase activity
I6K62_RS16505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS16510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS16530	COG0765	amino acid transport
I6K62_RS16535	COG1126	abc transporter atp-binding protein
I6K62_RS16550	COG3383	formate dehydrogenase (NAD+) activity
I6K62_RS16555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K62_RS16560	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K62_RS16565	COG0672	)-iron permease
I6K62_RS16580	COG0577	efflux transmembrane transporter activity
I6K62_RS16580	COG1136	(ABC) transporter
I6K62_RS16590	COG1136	(ABC) transporter
I6K62_RS16590	COG0577	efflux transmembrane transporter activity
I6K62_RS16605	COG1175	transmembrane transport
I6K62_RS16610	COG3842	ATPase activity
I6K62_RS16635	COG1278	Cold shock
I6K62_RS16640	COG0626	cystathionine gamma-synthase activity
I6K62_RS16645	COG1757	Na H antiporter
I6K62_RS16675	COG4993	Dehydrogenase
I6K62_RS16680	COG4608	Belongs to the ABC transporter superfamily
I6K62_RS16685	COG0444	Belongs to the ABC transporter superfamily
I6K62_RS16715	COG2011	ABC-type metal ion transport system permease component
I6K62_RS16730	COG0346	lactoylglutathione lyase activity
I6K62_RS16735	COG1349	DNA-binding transcription factor activity
I6K62_RS16750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K62_RS16755	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS16760	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K62_RS16770	COG4529	Protein conserved in bacteria
I6K62_RS16785	COG0366	Alpha amylase catalytic
I6K62_RS16790	COG1609	Transcriptional regulator
I6K62_RS16800	COG2323	membrane
I6K62_RS16805	COG1546	Belongs to the CinA family
I6K62_RS16815	COG0366	Alpha amylase catalytic
I6K62_RS16820	COG1294	oxidase, subunit
I6K62_RS16825	COG1271	oxidase subunit
I6K62_RS16830	COG3546	catalase activity
I6K62_RS16835	COG3685	Protein conserved in bacteria
I6K62_RS16840	COG3685	Protein conserved in bacteria
I6K62_RS16845	COG3729	General stress protein
I6K62_RS16870	COG0307	riboflavin synthase, alpha
I6K62_RS16875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K62_RS16880	COG2814	Major facilitator Superfamily
I6K62_RS16885	COG0583	DNA-binding transcription factor activity
I6K62_RS16900	COG2814	Major facilitator Superfamily
I6K62_RS16910	COG0791	NLP P60 protein
I6K62_RS16915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K62_RS16925	COG0346	lactoylglutathione lyase activity
I6K62_RS16930	COG1902	pentaerythritol trinitrate reductase activity
I6K62_RS16935	COG1309	transcriptional regulator
I6K62_RS16940	COG3313	Fe-S protein
I6K62_RS16945	COG4989	oxidoreductase activity
I6K62_RS16955	COG1289	transmembrane transporter activity
I6K62_RS16960	COG1566	PFAM secretion protein HlyD family protein
I6K62_RS16975	COG3706	GGDEF domain
I6K62_RS16990	COG3895	Periplasmic Protein
I6K62_RS17010	COG0625	glutathione transferase activity
I6K62_RS17020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K62_RS17030	COG4659	FMN binding
I6K62_RS17065	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS17075	COG0673	inositol 2-dehydrogenase activity
I6K62_RS17090	COG0425	Belongs to the sulfur carrier protein TusA family
I6K62_RS17095	COG2391	methyltransferase activity
I6K62_RS17105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K62_RS17110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS17110	COG1263	PTS System
I6K62_RS17115	COG1609	Transcriptional regulator
I6K62_RS17120	COG5339	Protein conserved in bacteria
I6K62_RS17125	COG1482	cell wall glycoprotein biosynthetic process
I6K62_RS17130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS17130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS17145	COG2205	protein histidine kinase activity
I6K62_RS17150	COG0745	RESPONSE REGULATOR receiver
I6K62_RS17160	COG3136	membrane protein required for alginate biosynthesis
I6K62_RS17170	COG0531	amino acid
I6K62_RS17185	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K62_RS17190	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K62_RS17200	COG0589	response to stress
I6K62_RS17205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K62_RS17210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K62_RS17215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K62_RS17220	COG1473	amidohydrolase
I6K62_RS17230	COG0583	DNA-binding transcription factor activity
I6K62_RS17235	COG2840	Smr protein MutS2
I6K62_RS17240	COG1414	Transcriptional regulator
I6K62_RS17250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K62_RS17255	COG0183	Belongs to the thiolase family
I6K62_RS17265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K62_RS17270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K62_RS17275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS17275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS17295	COG4565	transcriptional regulatory protein
I6K62_RS17300	COG3290	protein histidine kinase activity
I6K62_RS17305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6K62_RS17320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K62_RS17330	COG0679	Auxin Efflux Carrier
I6K62_RS17360	COG0628	permease
I6K62_RS17380	COG5001	Diguanylate cyclase
I6K62_RS17380	COG3300	MHYT domain
I6K62_RS17385	COG3591	Belongs to the peptidase S1B family
I6K62_RS17405	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K62_RS17410	COG2814	Major facilitator Superfamily
I6K62_RS17415	COG0583	DNA-binding transcription factor activity
I6K62_RS17420	COG1940	carbohydrate kinase activity
I6K62_RS17425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K62_RS17440	COG3302	dmso reductase anchor subunit
I6K62_RS17445	COG0437	4 iron, 4 sulfur cluster binding
I6K62_RS17465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K62_RS17480	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS17485	COG1063	alcohol dehydrogenase
I6K62_RS17490	COG0477	Major facilitator Superfamily
I6K62_RS17495	COG0246	Mannitol dehydrogenase
I6K62_RS17500	COG0589	response to stress
I6K62_RS17505	COG1802	Transcriptional regulator
I6K62_RS17510	COG4221	oxidoreductase activity
I6K62_RS17515	COG0339	signal peptide processing
I6K62_RS17555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K62_RS17570	COG2135	peptidase activity
I6K62_RS17590	COG3122	Protein conserved in bacteria
I6K62_RS17620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K62_RS17625	COG2223	nitrite transmembrane transporter activity
I6K62_RS17645	COG2200	EAL domain
I6K62_RS17680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K62_RS17715	COG2814	Major facilitator Superfamily
I6K62_RS17775	COG0861	Integral membrane protein TerC family
I6K62_RS17780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K62_RS17785	COG1454	alcohol dehydrogenase
I6K62_RS17790	COG3395	kinase activity
I6K62_RS17795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K62_RS17800	COG1349	DNA-binding transcription factor activity
I6K62_RS17815	COG0583	DNA-binding transcription factor activity
I6K62_RS17820	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS17835	COG2199	diguanylate cyclase activity
I6K62_RS17880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS17885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K62_RS17930	COG3121	Chaperone
I6K62_RS17955	COG0477	Major facilitator Superfamily
I6K62_RS17970	COG2011	ABC-type metal ion transport system permease component
I6K62_RS17990	COG4628	conserved protein (DUF2132)
I6K62_RS18005	COG1126	abc transporter atp-binding protein
I6K62_RS18010	COG0765	amino acid transport
I6K62_RS18015	COG0765	amino acid transport
I6K62_RS18035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K62_RS18040	COG2207	Transcriptional regulator
I6K62_RS18050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6K62_RS18055	COG1446	asparaginase
I6K62_RS18060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS18075	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6K62_RS18080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K62_RS18085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS18095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K62_RS18105	COG3775	system Galactitol-specific IIC component
I6K62_RS18110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K62_RS18115	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS18120	COG1070	Carbohydrate kinase
I6K62_RS18145	COG3188	usher protein
I6K62_RS18175	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS18190	COG1609	Transcriptional regulator
I6K62_RS18200	COG0693	protein deglycase activity
I6K62_RS18215	COG0412	Dienelactone hydrolase
I6K62_RS18230	COG0583	DNA-binding transcription factor activity
I6K62_RS18255	COG2841	Protein conserved in bacteria
I6K62_RS18280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS18295	COG4821	SIS domain
I6K62_RS18300	COG2188	Transcriptional regulator
I6K62_RS18305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K62_RS18330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K62_RS18380	COG3121	Chaperone
I6K62_RS18395	COG3539	Fimbrial protein
I6K62_RS18420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K62_RS18430	COG2271	Major facilitator Superfamily
I6K62_RS18440	COG3716	PTS system mannose fructose sorbose family IID component
I6K62_RS18450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS18450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS18470	COG4771	TonB-dependent receptor
I6K62_RS18475	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K62_RS18495	COG2226	methyltransferase
I6K62_RS18495	COG3433	isochorismatase activity
I6K62_RS18495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K62_RS18505	COG1132	(ABC) transporter
I6K62_RS18510	COG1132	(ABC) transporter
I6K62_RS18515	COG2814	Major facilitator Superfamily
I6K62_RS18545	COG0814	amino acid
I6K62_RS18550	COG1760	l-serine dehydratase
I6K62_RS18575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K62_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS18595	COG0401	homolog of Blt101
I6K62_RS18610	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K62_RS18615	COG2200	EAL domain
I6K62_RS18615	COG2771	luxR family
I6K62_RS18620	COG1649	PFAM Uncharacterised BCR, COG1649
I6K62_RS18665	COG1082	Xylose isomerase domain protein TIM barrel
I6K62_RS18670	COG0673	inositol 2-dehydrogenase activity
I6K62_RS18675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K62_RS18680	COG1116	anion transmembrane transporter activity
I6K62_RS18685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K62_RS18690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K62_RS18695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K62_RS18700	COG0076	glutamate decarboxylase activity
I6K62_RS18705	COG0300	oxidoreductase activity
I6K62_RS18715	COG0519	Catalyzes the synthesis of GMP from XMP
I6K62_RS18715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K62_RS18775	COG2271	Major facilitator Superfamily
I6K62_RS18785	COG0583	DNA-binding transcription factor activity
I6K62_RS18790	COG0583	DNA-binding transcription factor activity
I6K62_RS18805	COG0243	molybdopterin cofactor binding
I6K62_RS18810	COG3781	membrane
I6K62_RS18825	COG1764	response to oxidative stress
I6K62_RS18855	COG0745	RESPONSE REGULATOR receiver
I6K62_RS18860	COG0488	(ABC) transporter
I6K62_RS18875	COG1064	alcohol dehydrogenase
I6K62_RS18890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K62_RS18900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K62_RS18910	COG2814	Major facilitator Superfamily
I6K62_RS18920	COG2864	formate dehydrogenase
I6K62_RS18925	COG0437	4 iron, 4 sulfur cluster binding
I6K62_RS18935	COG0697	spore germination
I6K62_RS18950	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K62_RS18960	COG3485	protocatechuate 3,4-dioxygenase
I6K62_RS18965	COG4829	muconolactone delta-isomerase
I6K62_RS18970	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS18975	COG1414	Transcriptional regulator
I6K62_RS18990	COG2223	nitrite transmembrane transporter activity
I6K62_RS18995	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K62_RS19000	COG1140	nitrate reductase beta subunit
I6K62_RS19005	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K62_RS19010	COG2181	nitrate reductase activity
I6K62_RS19020	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K62_RS19025	COG1178	ABC-type Fe3 transport system permease component
I6K62_RS19030	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K62_RS19035	COG3842	ATPase activity
I6K62_RS19040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K62_RS19045	COG4977	sequence-specific DNA binding
I6K62_RS19055	COG2211	Major facilitator Superfamily
I6K62_RS19070	COG0625	glutathione transferase activity
I6K62_RS19075	COG1609	Transcriptional regulator
I6K62_RS19085	COG2271	Major facilitator Superfamily
I6K62_RS19095	COG1126	abc transporter atp-binding protein
I6K62_RS19100	COG0765	amino acid transport
I6K62_RS19115	COG1473	amidohydrolase
I6K62_RS19120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K62_RS19145	COG4772	TonB-dependent receptor
I6K62_RS19150	COG3691	Protein conserved in bacteria
I6K62_RS19160	COG2130	NADP-dependent
I6K62_RS19175	COG1247	-acetyltransferase
I6K62_RS19180	COG3238	Protein conserved in bacteria
I6K62_RS19190	COG0747	negative chemotaxis
I6K62_RS19195	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS19200	COG4677	pectinesterase activity
I6K62_RS19230	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS19235	COG1177	transmembrane transport
I6K62_RS19240	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K62_RS19245	COG3842	ATPase activity
I6K62_RS19250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K62_RS19255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K62_RS19260	COG1271	oxidase subunit
I6K62_RS19265	COG1294	oxidase, subunit
I6K62_RS19280	COG0826	peptidase U32
I6K62_RS19285	COG1396	sequence-specific DNA binding
I6K62_RS19290	COG3135	benzoate transporter
I6K62_RS19300	COG0697	spore germination
I6K62_RS19310	COG0747	negative chemotaxis
I6K62_RS19315	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K62_RS19320	COG0500	methyltransferase
I6K62_RS19325	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K62_RS19330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K62_RS19335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K62_RS19345	COG1335	isochorismatase
I6K62_RS19355	COG5383	Protein conserved in bacteria
I6K62_RS19360	COG3485	protocatechuate 3,4-dioxygenase
I6K62_RS19365	COG3485	protocatechuate 3,4-dioxygenase
I6K62_RS19370	COG0583	DNA-binding transcription factor activity
I6K62_RS19405	COG3038	cytochrome b561
I6K62_RS19425	COG3706	GGDEF domain
I6K62_RS19430	COG0583	DNA-binding transcription factor activity
I6K62_RS19440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K62_RS19445	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS19450	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K62_RS19455	COG0477	Major facilitator Superfamily
I6K62_RS19460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K62_RS19480	COG1538	Outer membrane efflux protein
I6K62_RS19485	COG4122	O-methyltransferase activity
I6K62_RS19490	COG1643	Atp-dependent helicase
I6K62_RS19505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K62_RS19510	COG3327	negative regulation of DNA-templated transcription, initiation
I6K62_RS19515	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K62_RS19520	COG0183	Belongs to the thiolase family
I6K62_RS19525	COG2050	protein possibly involved in aromatic compounds catabolism
I6K62_RS19530	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K62_RS19535	COG1024	Enoyl-CoA hydratase
I6K62_RS19540	COG1024	Enoyl-CoA hydratase
I6K62_RS19545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K62_RS19550	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K62_RS19555	COG3396	Phenylacetate-CoA oxygenase
I6K62_RS19560	COG3460	Phenylacetate-CoA oxygenase
I6K62_RS19565	COG3396	Phenylacetate-CoA oxygenase
I6K62_RS19570	COG2030	dehydratase
I6K62_RS19570	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS19590	COG0191	fructose-bisphosphate aldolase activity
I6K62_RS19600	COG3775	system Galactitol-specific IIC component
I6K62_RS19605	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K62_RS19615	COG2188	Transcriptional regulator
I6K62_RS19620	COG0406	alpha-ribazole phosphatase activity
I6K62_RS19630	COG4977	sequence-specific DNA binding
I6K62_RS19655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS19660	COG2207	Transcriptional regulator
I6K62_RS19660	COG3708	Transcriptional regulator
I6K62_RS19670	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS19675	COG2207	Transcriptional regulator
I6K62_RS19680	COG3784	Protein of unknown function (DUF1318)
I6K62_RS19690	COG2911	Protein conserved in bacteria
I6K62_RS19695	COG0586	Pfam SNARE associated Golgi protein
I6K62_RS19700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K62_RS19705	COG3187	Heat shock protein
I6K62_RS19710	COG3042	response to heat
I6K62_RS19790	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K62_RS19790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K62_RS19790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K62_RS19790	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K62_RS19795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K62_RS19805	COG0589	response to stress
I6K62_RS19815	COG0513	Belongs to the DEAD box helicase family
I6K62_RS19825	COG2197	response regulator
I6K62_RS19830	COG3539	Fimbrial protein
I6K62_RS19845	COG3121	Chaperone
I6K62_RS19850	COG3539	Fimbrial protein
I6K62_RS19860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K62_RS19865	COG1349	DNA-binding transcription factor activity
I6K62_RS19870	COG0673	inositol 2-dehydrogenase activity
I6K62_RS19880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K62_RS19895	COG3477	response to acidic pH
I6K62_RS19925	COG0583	DNA-binding transcription factor activity
I6K62_RS19955	COG0789	Transcriptional regulator
I6K62_RS19965	COG0300	oxidoreductase activity
I6K62_RS19980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K62_RS19990	COG3272	Protein of unknown function (DUF1722)
I6K62_RS20085	COG2885	chlorophyll binding
I6K62_RS20105	COG4166	transmembrane transport
I6K62_RS20110	COG2866	Carboxypeptidase
I6K62_RS20115	COG4948	Mandelate Racemase Muconate Lactonizing
I6K62_RS20120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K62_RS20125	COG3180	Ammonia monooxygenase
I6K62_RS20140	COG3106	COG3106 Predicted ATPase
I6K62_RS20145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K62_RS20155	COG1983	PspC domain protein
I6K62_RS20165	COG1842	Phage shock protein A
I6K62_RS20170	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K62_RS20180	COG1473	amidohydrolase
I6K62_RS20200	COG4168	peptide transport system, permease
I6K62_RS20220	COG3210	domain, Protein
I6K62_RS20235	COG4171	peptide transport system, permease
I6K62_RS20245	COG4172	Belongs to the ABC transporter superfamily
I6K62_RS20255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K62_RS20260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K62_RS20260	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K62_RS20275	COG1349	DNA-binding transcription factor activity
I6K62_RS20285	COG0023	Translation Initiation Factor
I6K62_RS20295	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K62_RS20300	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K62_RS20305	COG0671	phosphoesterase, PA-phosphatase related
I6K62_RS20315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K62_RS20340	COG0616	signal peptide processing
I6K62_RS20345	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS20350	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K62_RS20355	COG2207	Transcriptional regulator
I6K62_RS20360	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K62_RS20365	COG2211	Major facilitator Superfamily
I6K62_RS20370	COG1187	pseudouridine synthase activity
I6K62_RS20375	COG0009	L-threonylcarbamoyladenylate synthase
I6K62_RS20385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K62_RS20390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K62_RS20390	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K62_RS20395	COG0134	indole-3-glycerol-phosphate synthase activity
I6K62_RS20395	COG0135	phosphoribosylanthranilate isomerase activity
I6K62_RS20410	COG2207	Transcriptional regulator
I6K62_RS20410	COG3708	Transcriptional regulator
I6K62_RS20425	COG3047	cAMP biosynthetic process
I6K62_RS20440	COG0038	chloride channel
I6K62_RS20460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS20465	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS20470	COG1988	membrane-bound metal-dependent
I6K62_RS20475	COG1823	symporter activity
I6K62_RS20485	COG0753	catalase activity
I6K62_RS20495	COG1486	melibiose metabolic process
I6K62_RS20500	COG1917	Cupin 2, conserved barrel domain protein
I6K62_RS20500	COG2169	Transcriptional regulator
I6K62_RS20505	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K62_RS20510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS20515	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS20520	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K62_RS20530	COG0322	excinuclease ABC activity
I6K62_RS20540	COG1704	LemA family
I6K62_RS20545	COG3678	ATP-independent chaperone mediated protein folding
I6K62_RS20555	COG3724	N-succinylarginine dihydrolase activity
I6K62_RS20575	COG0708	Exodeoxyribonuclease III
I6K62_RS20580	COG0398	Pfam SNARE associated Golgi protein
I6K62_RS20585	COG0398	Pfam SNARE associated Golgi protein
I6K62_RS20590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K62_RS20595	COG4134	Bacterial extracellular solute-binding protein
I6K62_RS20600	COG4135	transport system, permease component
I6K62_RS20605	COG4136	ATPase activity
I6K62_RS20610	COG2897	thiosulfate sulfurtransferase activity
I6K62_RS20620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K62_RS20625	COG0494	nUDIX hydrolase
I6K62_RS20630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K62_RS20635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K62_RS20640	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K62_RS20650	COG0778	Nitroreductase
I6K62_RS20655	COG0616	signal peptide processing
I6K62_RS20660	COG0252	asparaginase activity
I6K62_RS20665	COG1335	isochorismatase
I6K62_RS20670	COG2814	Major facilitator Superfamily
I6K62_RS20675	COG1349	DNA-binding transcription factor activity
I6K62_RS20680	COG0667	Aldo Keto reductase
I6K62_RS20685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS20690	COG0191	fructose-bisphosphate aldolase activity
I6K62_RS20695	COG1063	alcohol dehydrogenase
I6K62_RS20700	COG2271	Major facilitator Superfamily
I6K62_RS20705	COG1063	alcohol dehydrogenase
I6K62_RS20720	COG3139	Protein of unknown function (DUF1315)
I6K62_RS20740	COG0656	L-ascorbic acid biosynthetic process
I6K62_RS20745	COG3713	MltA-interacting MipA family protein
I6K62_RS20750	COG2766	serine protein kinase
I6K62_RS20760	COG0859	PFAM glycosyl transferase family 9
I6K62_RS20780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K62_RS20790	COG2207	Transcriptional regulator
I6K62_RS20795	COG2807	transmembrane transport
I6K62_RS20800	COG0504	CTP synthase activity
I6K62_RS20805	COG1683	Conserved Protein
I6K62_RS20810	COG3189	MarR family transcriptional regulator
I6K62_RS20815	COG3042	response to heat
I6K62_RS20820	COG2203	Gaf domain
I6K62_RS20820	COG2199	diguanylate cyclase activity
I6K62_RS20840	COG3182	Iron-regulated membrane protein
I6K62_RS20850	COG1560	Kdo2-lipid A biosynthetic process
I6K62_RS20855	COG2226	methyltransferase
I6K62_RS20860	COG1595	DNA-templated transcription, initiation
I6K62_RS20865	COG3712	iron ion homeostasis
I6K62_RS20870	COG4772	TonB-dependent receptor
I6K62_RS20875	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K62_RS20890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K62_RS20895	COG3706	GGDEF domain
I6K62_RS20905	COG0538	isocitrate dehydrogenase activity
I6K62_RS20910	COG1187	pseudouridine synthase activity
I6K62_RS20930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K62_RS20935	COG2814	Major facilitator Superfamily
I6K62_RS20945	COG0745	RESPONSE REGULATOR receiver
I6K62_RS20950	COG2205	protein histidine kinase activity
I6K62_RS20955	COG2850	peptidyl-arginine hydroxylation
I6K62_RS20975	COG1177	transmembrane transport
I6K62_RS20990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K62_RS20995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K62_RS21000	COG0698	ribose 5-phosphate isomerase
I6K62_RS21015	COG3395	kinase activity
I6K62_RS21030	COG2390	Transcriptional regulator
I6K62_RS21040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K62_RS21050	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K62_RS21055	COG1136	(ABC) transporter
I6K62_RS21060	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K62_RS21065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K62_RS21070	COG1388	LysM domain
I6K62_RS21070	COG1376	ErfK ybiS ycfS ynhG family protein
I6K62_RS21080	COG1309	transcriptional regulator
I6K62_RS21090	COG3134	Outer membrane lipoprotein
I6K62_RS21095	COG1252	NADH dehydrogenase
I6K62_RS21120	COG5633	Lipoprotein
I6K62_RS21125	COG0537	adenosine 5'-monophosphoramidase activity
I6K62_RS21130	COG4773	Receptor
I6K62_RS21140	COG0084	hydrolase, TatD family'
I6K62_RS21145	COG0470	DNA polymerase III
I6K62_RS21155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K62_RS21160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K62_RS21195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K62_RS21210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K62_RS21230	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K62_RS21250	COG1530	ribonuclease E activity
I6K62_RS21255	COG0583	DNA-binding transcription factor activity
I6K62_RS21260	COG2814	Major facilitator Superfamily
I6K62_RS21280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K62_RS21290	COG2999	glutathione oxidoreductase activity
I6K62_RS21330	COG1560	Kdo2-lipid A biosynthetic process
I6K62_RS21345	COG5645	(Lipo)protein
I6K62_RS21385	COG3381	protein complex oligomerization
I6K62_RS21405	COG0583	DNA-binding transcription factor activity
I6K62_RS21415	COG1335	isochorismatase
I6K62_RS21435	COG1702	phosphate starvation-inducible protein PhoH
I6K62_RS21455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K62_RS21465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K62_RS21480	COG1309	transcriptional regulator
I6K62_RS21515	COG2233	PERMEase
I6K62_RS21520	COG3729	General stress protein
I6K62_RS21550	COG0531	amino acid
I6K62_RS21555	COG0174	glutamine synthetase
I6K62_RS21560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K62_RS21565	COG1917	Cupin 2, conserved barrel domain protein
I6K62_RS21565	COG1396	sequence-specific DNA binding
I6K62_RS21570	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS21575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K62_RS21580	COG0583	DNA-binding transcription factor activity
I6K62_RS21585	COG0473	3-isopropylmalate dehydrogenase activity
I6K62_RS21590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K62_RS21590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS21590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS21595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS21600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS21605	COG1882	Formate acetyltransferase
I6K62_RS21610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K62_RS21615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K62_RS21625	COG2207	Transcriptional regulator
I6K62_RS21630	COG3706	GGDEF domain
I6K62_RS21660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K62_RS21675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K62_RS21685	COG0765	amino acid transport
I6K62_RS21740	COG1953	Uracil, thiamine, allantoin
I6K62_RS21745	COG0402	S-adenosylhomocysteine deaminase activity
I6K62_RS21750	COG2351	hydroxyisourate hydrolase activity
I6K62_RS21760	COG2233	PERMEase
I6K62_RS21765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K62_RS21810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K62_RS21830	COG1652	LysM domain
I6K62_RS21835	COG1278	Cold shock
I6K62_RS21840	COG1278	Cold shock
I6K62_RS21850	COG0436	Aminotransferase
I6K62_RS21855	COG1757	Na H antiporter
I6K62_RS21860	COG1609	Transcriptional regulator
I6K62_RS21865	COG3711	transcriptional antiterminator
I6K62_RS21870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS21870	COG3711	transcriptional antiterminator
I6K62_RS21895	COG0670	Belongs to the BI1 family
I6K62_RS21900	COG2920	part of a sulfur-relay system
I6K62_RS21910	COG2207	Transcriptional regulator
I6K62_RS21915	COG1881	PFAM PEBP family protein
I6K62_RS21935	COG0438	transferase activity, transferring glycosyl groups
I6K62_RS21940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS21945	COG2274	protein secretion by the type I secretion system
I6K62_RS21980	COG1832	CoA-binding protein
I6K62_RS21990	COG0210	DNA helicase
I6K62_RS21995	COG3304	Inner membrane component domain
I6K62_RS22000	COG1289	transmembrane transporter activity
I6K62_RS22005	COG3070	regulator of competence-specific genes
I6K62_RS22025	COG1067	ATP-dependent peptidase activity
I6K62_RS22035	COG3130	regulation of translation
I6K62_RS22040	COG3009	Protein conserved in bacteria
I6K62_RS22045	COG3008	intermembrane lipid transfer
I6K62_RS22045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K62_RS22050	COG2995	paraquat-inducible protein a
I6K62_RS22055	COG0488	(ABC) transporter
I6K62_RS22065	COG3217	Mosc domain protein beta barrel domain protein
I6K62_RS22065	COG0633	Ferredoxin
I6K62_RS22080	COG0431	NADPH-dependent FMN reductase
I6K62_RS22085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K62_RS22095	COG0308	aminopeptidase N
I6K62_RS22100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6K62_RS22110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K62_RS22115	COG1448	Aminotransferase
I6K62_RS22120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K62_RS22125	COG3108	Peptidase M15
I6K62_RS22130	COG2989	Protein conserved in bacteria
I6K62_RS22140	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K62_RS22150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K62_RS22155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K62_RS22160	COG3173	Aminoglycoside phosphotransferase
I6K62_RS22175	COG3214	Protein conserved in bacteria
I6K62_RS22185	COG1132	(ABC) transporter
I6K62_RS22190	COG2333	competence protein COMEC
I6K62_RS22190	COG0658	competence protein
I6K62_RS22200	COG0539	negative regulation of cytoplasmic translation
I6K62_RS22210	COG0501	Belongs to the peptidase M48B family
I6K62_RS22225	COG2323	membrane
I6K62_RS22230	COG1944	ATP diphosphatase activity
I6K62_RS22235	COG2116	formate transmembrane transporter activity
I6K62_RS22240	COG1882	Formate acetyltransferase
I6K62_RS22245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K62_RS22250	COG1737	Transcriptional regulator
I6K62_RS22265	COG3959	Transketolase, thiamine diphosphate binding domain
I6K62_RS22270	COG3958	Transketolase
I6K62_RS22275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS22280	COG0477	Major facilitator Superfamily
I6K62_RS22290	COG3302	dmso reductase anchor subunit
I6K62_RS22295	COG0437	4 iron, 4 sulfur cluster binding
I6K62_RS22300	COG0243	molybdopterin cofactor binding
I6K62_RS22310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K62_RS22320	COG1674	ftsk spoiiie
I6K62_RS22320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K62_RS22330	COG0492	ferredoxin-NADP+ reductase activity
I6K62_RS22335	COG4988	ABC transporter
I6K62_RS22340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K62_RS22350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6K62_RS22360	COG0542	response to heat
I6K62_RS22370	COG1278	Cold shock
I6K62_RS22380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS22385	COG3593	DNA synthesis involved in DNA repair
I6K62_RS22390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K62_RS22395	COG2431	L-lysine efflux transmembrane transporter activity
I6K62_RS22405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K62_RS22415	COG0028	Belongs to the TPP enzyme family
I6K62_RS22420	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K62_RS22425	COG0702	epimerase
I6K62_RS22430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K62_RS22435	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K62_RS22440	COG0393	Putative heavy-metal-binding
I6K62_RS22450	COG1126	abc transporter atp-binding protein
I6K62_RS22455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS22460	COG4215	(ABC) transporter
I6K62_RS22465	COG4160	amino acid transport
I6K62_RS22470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS22475	COG5002	protein histidine kinase activity
I6K62_RS22480	COG0745	RESPONSE REGULATOR receiver
I6K62_RS22495	COG1177	transmembrane transport
I6K62_RS22500	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K62_RS22505	COG3842	ATPase activity
I6K62_RS22510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K62_RS22525	COG0778	Nitroreductase
I6K62_RS22550	COG3226	Transcriptional regulator
I6K62_RS22555	COG0738	Major facilitator superfamily
I6K62_RS22560	COG0561	phosphatase activity
I6K62_RS22565	COG2814	Major facilitator Superfamily
I6K62_RS22570	COG0671	phosphoesterase, PA-phosphatase related
I6K62_RS22575	COG1349	DNA-binding transcription factor activity
I6K62_RS22580	COG1686	Belongs to the peptidase S11 family
I6K62_RS22585	COG0625	glutathione transferase activity
I6K62_RS22590	COG2133	pyrroloquinoline quinone binding
I6K62_RS22600	COG2223	nitrite transmembrane transporter activity
I6K62_RS22625	COG0747	negative chemotaxis
I6K62_RS22635	COG1446	asparaginase
I6K62_RS22640	COG0303	'Molybdopterin
I6K62_RS22645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K62_RS22650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K62_RS22655	COG1882	Formate acetyltransferase
I6K62_RS22660	COG0561	phosphatase activity
I6K62_RS22670	COG1609	Transcriptional regulator
I6K62_RS22675	COG2271	Major facilitator Superfamily
I6K62_RS22685	COG0488	(ABC) transporter
I6K62_RS22695	COG1376	ErfK ybiS ycfS ynhG family protein
I6K62_RS22700	COG2188	Transcriptional regulator
I6K62_RS22705	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS22710	COG0667	Aldo Keto reductase
I6K62_RS22715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K62_RS22730	COG2194	sulfuric ester hydrolase activity
I6K62_RS22735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K62_RS22750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS22755	COG0765	amino acid transport
I6K62_RS22760	COG1126	abc transporter atp-binding protein
I6K62_RS22765	COG0668	transmembrane transport
I6K62_RS22775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K62_RS22780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K62_RS22790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K62_RS22805	COG0513	Belongs to the DEAD box helicase family
I6K62_RS22810	COG3958	Transketolase
I6K62_RS22815	COG3959	Transketolase, thiamine diphosphate binding domain
I6K62_RS22820	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS22825	COG2271	Major facilitator Superfamily
I6K62_RS22830	COG0583	DNA-binding transcription factor activity
I6K62_RS22835	COG1309	transcriptional regulator
I6K62_RS22840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS22845	COG1131	(ABC) transporter
I6K62_RS22850	COG0842	Transport permease protein
I6K62_RS22855	COG0842	Transport permease protein
I6K62_RS22865	COG3568	Endonuclease Exonuclease Phosphatase
I6K62_RS22870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K62_RS22875	COG0392	lysyltransferase activity
I6K62_RS22880	COG0670	Belongs to the BI1 family
I6K62_RS22885	COG0314	molybdopterin synthase activity
I6K62_RS22890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K62_RS22900	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K62_RS22920	COG0745	RESPONSE REGULATOR receiver
I6K62_RS22945	COG2226	methyltransferase
I6K62_RS22960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K62_RS22965	COG1881	PFAM PEBP family protein
I6K62_RS23005	COG4677	pectinesterase activity
I6K62_RS23020	COG0789	Transcriptional regulator
I6K62_RS23025	COG2200	EAL domain
I6K62_RS23045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K62_RS23060	COG0561	phosphatase activity
I6K62_RS23070	COG4149	molybdate abc transporter
I6K62_RS23075	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K62_RS23085	COG3585	molybdate ion transport
I6K62_RS23085	COG2005	Transcriptional regulator
I6K62_RS23090	COG1119	ATPase activity
I6K62_RS23095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K62_RS23100	COG1085	galactose-1-phosphate uridylyltransferase
I6K62_RS23110	COG2017	converts alpha-aldose to the beta-anomer
I6K62_RS23120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K62_RS23140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K62_RS23170	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K62_RS23175	COG2885	chlorophyll binding
I6K62_RS23185	COG3064	Membrane
I6K62_RS23185	COG3064	Membrane
I6K62_RS23190	COG0848	biopolymer transport protein
I6K62_RS23195	COG0811	peptide transport
I6K62_RS23200	COG0824	Thioesterase
I6K62_RS23205	COG3790	cyd operon protein YbgE
I6K62_RS23210	COG4890	Cyd operon protein YbgT
I6K62_RS23215	COG1294	oxidase, subunit
I6K62_RS23220	COG1271	oxidase subunit
I6K62_RS23225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K62_RS23235	COG4865	methylaspartate mutase activity
I6K62_RS23240	COG3799	methylaspartate ammonia-lyase activity
I6K62_RS23255	COG1301	dicarboxylic acid transport
I6K62_RS23265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS23265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K62_RS23275	COG0583	DNA-binding transcription factor activity
I6K62_RS23285	COG3395	kinase activity
I6K62_RS23290	COG0235	Class ii aldolase
I6K62_RS23295	COG1349	DNA-binding transcription factor activity
I6K62_RS23300	COG3622	Belongs to the hyi family
I6K62_RS23305	COG3246	L-lysine catabolic process to acetate
I6K62_RS23325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K62_RS23335	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K62_RS23340	COG0567	Dehydrogenase, E1 component
I6K62_RS23345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K62_RS23350	COG1053	succinate dehydrogenase
I6K62_RS23355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K62_RS23365	COG0372	Belongs to the citrate synthase family
I6K62_RS23395	COG1984	allophanate hydrolase subunit 2
I6K62_RS23400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K62_RS23405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K62_RS23415	COG0415	Belongs to the DNA photolyase family
I6K62_RS23445	COG2205	protein histidine kinase activity
I6K62_RS23450	COG0745	RESPONSE REGULATOR receiver
I6K62_RS23460	COG3623	hexulose-6-phosphate isomerase
I6K62_RS23465	COG1070	Carbohydrate kinase
I6K62_RS23470	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS23475	COG1129	ABC transporter
I6K62_RS23480	COG1879	ABC-type sugar transport system periplasmic component
I6K62_RS23485	COG1063	alcohol dehydrogenase
I6K62_RS23490	COG1349	DNA-binding transcription factor activity
I6K62_RS23500	COG0033	Phosphoglucomutase
I6K62_RS23505	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K62_RS23510	COG0596	Alpha beta hydrolase
I6K62_RS23525	COG0735	belongs to the Fur family
I6K62_RS23530	COG0583	DNA-binding transcription factor activity
I6K62_RS23535	COG1053	succinate dehydrogenase
I6K62_RS23575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K62_RS23580	COG1940	carbohydrate kinase activity
I6K62_RS23580	COG1846	Transcriptional regulator
I6K62_RS23585	COG0647	UMP catabolic process
I6K62_RS23590	COG0367	asparagine synthase
I6K62_RS23630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K62_RS23640	COG1702	phosphate starvation-inducible protein PhoH
I6K62_RS23650	COG4535	Mg2 and Co2 transporter CorC
I6K62_RS23665	COG0765	amino acid transport
I6K62_RS23670	COG0765	amino acid transport
I6K62_RS23675	COG1126	abc transporter atp-binding protein
I6K62_RS23680	COG2831	hemolysin activation secretion protein
I6K62_RS23685	COG3210	domain, Protein
I6K62_RS23690	COG2888	peptidyl-tyrosine sulfation
I6K62_RS23705	COG1466	dna polymerase III delta subunit
I6K62_RS23715	COG0406	alpha-ribazole phosphatase activity
I6K62_RS23720	COG0799	negative regulation of ribosome biogenesis
I6K62_RS23730	COG0768	penicillin binding
I6K62_RS23735	COG0772	Belongs to the SEDS family
I6K62_RS23740	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K62_RS23745	COG1686	Belongs to the peptidase S11 family
I6K62_RS23760	COG0583	DNA-binding transcription factor activity
I6K62_RS23770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K62_RS23775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K62_RS23795	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K62_RS23800	COG3719	Belongs to the RNase T2 family
I6K62_RS23805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K62_RS23815	COG3634	alkyl hydroperoxide reductase activity
I6K62_RS23825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K62_RS23830	COG0583	DNA-binding transcription factor activity
I6K62_RS23835	COG3969	phosphoadenosine phosphosulfate
I6K62_RS23840	COG1475	DNA binding
I6K62_RS23845	COG0436	Aminotransferase
I6K62_RS23850	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6K62_RS23855	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6K62_RS23870	COG1129	ABC transporter
I6K62_RS23875	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS23880	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS23890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K62_RS23905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K62_RS23915	COG0402	S-adenosylhomocysteine deaminase activity
I6K62_RS23925	COG0483	inositol monophosphate 1-phosphatase activity
I6K62_RS23930	COG2271	Major facilitator Superfamily
I6K62_RS23960	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS23965	COG1129	ABC transporter
I6K62_RS23970	COG0371	Dehydrogenase
I6K62_RS23985	COG2879	small protein
I6K62_RS23990	COG1966	Carbon starvation protein
I6K62_RS24005	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS24010	COG1535	isochorismatase
I6K62_RS24010	COG3433	isochorismatase activity
I6K62_RS24015	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K62_RS24020	COG1169	isochorismate synthase
I6K62_RS24025	COG4592	Periplasmic binding protein
I6K62_RS24040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS24045	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS24050	COG1120	ATPase activity
I6K62_RS24055	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K62_RS24055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K62_RS24060	COG3251	PFAM MbtH domain protein
I6K62_RS24065	COG2382	esterase
I6K62_RS24070	COG4771	TonB-dependent receptor
I6K62_RS24075	COG2977	Belongs to the P-Pant transferase superfamily
I6K62_RS24080	COG3958	Transketolase
I6K62_RS24085	COG3959	Transketolase, thiamine diphosphate binding domain
I6K62_RS24090	COG2390	Transcriptional regulator
I6K62_RS24095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K62_RS24100	COG1879	ABC-type sugar transport system periplasmic component
I6K62_RS24110	COG1129	ABC transporter
I6K62_RS24115	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS24125	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS24130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS24140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K62_RS24165	COG0747	negative chemotaxis
I6K62_RS24170	COG0601	transmembrane transport
I6K62_RS24175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K62_RS24180	COG0444	Belongs to the ABC transporter superfamily
I6K62_RS24185	COG4172	Belongs to the ABC transporter superfamily
I6K62_RS24190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K62_RS24195	COG4221	oxidoreductase activity
I6K62_RS24205	COG0765	amino acid transport
I6K62_RS24210	COG0765	amino acid transport
I6K62_RS24215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K62_RS24230	COG0697	spore germination
I6K62_RS24240	COG0154	amidase activity
I6K62_RS24245	COG0444	Belongs to the ABC transporter superfamily
I6K62_RS24250	COG4608	Belongs to the ABC transporter superfamily
I6K62_RS24255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K62_RS24265	COG4166	transmembrane transport
I6K62_RS24275	COG3698	Phosphodiester glycosidase
I6K62_RS24325	COG2315	Protein conserved in bacteria
I6K62_RS24330	COG0778	Nitroreductase
I6K62_RS24340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS24350	COG3716	PTS system mannose fructose sorbose family IID component
I6K62_RS24360	COG2222	sugar isomerase
I6K62_RS24365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K62_RS24365	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K62_RS24380	COG0477	Major facilitator Superfamily
I6K62_RS24385	COG0668	transmembrane transport
I6K62_RS24395	COG0494	nUDIX hydrolase
I6K62_RS24415	COG3188	usher protein
I6K62_RS24430	COG2771	luxR family
I6K62_RS24435	COG0583	DNA-binding transcription factor activity
I6K62_RS24440	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS24460	COG2211	Major facilitator Superfamily
I6K62_RS24465	COG1113	amino acid transport
I6K62_RS24480	COG0667	Aldo Keto reductase
I6K62_RS24485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS24490	COG1473	amidohydrolase
I6K62_RS24495	COG3539	Fimbrial protein
I6K62_RS24500	COG3121	Chaperone
I6K62_RS24515	COG3121	Chaperone
I6K62_RS24555	COG3711	transcriptional antiterminator
I6K62_RS24560	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS24565	COG2190	(PTS) system
I6K62_RS24565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS24565	COG1263	PTS System
I6K62_RS24570	COG0583	DNA-binding transcription factor activity
I6K62_RS24610	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K62_RS24615	COG1129	ABC transporter
I6K62_RS24630	COG0673	inositol 2-dehydrogenase activity
I6K62_RS24655	COG3104	oligopeptide transport
I6K62_RS24665	COG0531	amino acid
I6K62_RS24670	COG3710	Transcriptional regulator
I6K62_RS24680	COG0583	DNA-binding transcription factor activity
I6K62_RS24690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K62_RS24715	COG1285	pathogenesis
I6K62_RS24720	COG2211	Major facilitator Superfamily
I6K62_RS24750	COG0813	purine-nucleoside phosphorylase activity
I6K62_RS24770	COG2501	S4 domain
I6K62_RS24780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K62_RS24795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K62_RS24800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K62_RS24805	COG0549	Belongs to the carbamate kinase family
I6K62_RS24815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K62_RS24820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K62_RS24825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K62_RS24830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K62_RS24835	COG3257	ureidoglycine aminohydrolase activity
I6K62_RS24840	COG1929	Belongs to the glycerate kinase type-1 family
I6K62_RS24845	COG2233	PERMEase
I6K62_RS24855	COG1953	Uracil, thiamine, allantoin
I6K62_RS24865	COG2084	Dehydrogenase
I6K62_RS24870	COG3622	Belongs to the hyi family
I6K62_RS24875	COG3960	tartronate-semialdehyde synthase activity
I6K62_RS24910	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K62_RS24915	COG4181	ATPase activity
I6K62_RS24920	COG2755	lipolytic protein G-D-S-L family
I6K62_RS24925	COG0300	oxidoreductase activity
I6K62_RS24930	COG3118	belongs to the thioredoxin family
I6K62_RS24935	COG0390	transport system, permease component
I6K62_RS24940	COG4619	ABC transporter
I6K62_RS24945	COG0330	HflC and HflK could
I6K62_RS24950	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K62_RS24965	COG3735	TraB family
I6K62_RS24970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K62_RS25015	COG2223	nitrite transmembrane transporter activity
I6K62_RS25020	COG4651	solute:proton antiporter activity
I6K62_RS25020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K62_RS25025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS25055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K62_RS25065	COG2832	Protein of unknown function (DUF454)
I6K62_RS25070	COG3923	Primosomal replication protein n
I6K62_RS25085	COG3264	Mechanosensitive ion channel
I6K62_RS25085	COG1196	nuclear chromosome segregation
I6K62_RS25090	COG1309	transcriptional regulator
I6K62_RS25095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS25100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K62_RS25115	COG0110	maltose O-acetyltransferase activity
I6K62_RS25135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6K62_RS25155	COG1263	PTS System
I6K62_RS25155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS25160	COG1874	Beta-galactosidase
I6K62_RS25165	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K62_RS25170	COG3833	ABC-type maltose transport systems, permease component
I6K62_RS25175	COG1175	transmembrane transport
I6K62_RS25180	COG2182	Extracellular solute-binding protein
I6K62_RS25190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K62_RS25205	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K62_RS25210	COG2364	Membrane
I6K62_RS25235	COG3695	enzyme binding
I6K62_RS25240	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K62_RS25245	COG1946	Acyl-CoA thioesterase
I6K62_RS25250	COG0583	DNA-binding transcription factor activity
I6K62_RS25255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K62_RS25260	COG1811	Na channel or pump
I6K62_RS25265	COG0004	ammonium transporteR
I6K62_RS25270	COG0347	Belongs to the P(II) protein family
I6K62_RS25275	COG1132	(ABC) transporter
I6K62_RS25280	COG1132	(ABC) transporter
I6K62_RS25285	COG1522	sequence-specific DNA binding
I6K62_RS25300	COG4533	DNA binding
I6K62_RS25310	COG0824	Thioesterase
I6K62_RS25315	COG1555	photosystem II stabilization
I6K62_RS25320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K62_RS25325	COG0776	regulation of translation
I6K62_RS25330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K62_RS25350	COG0271	Belongs to the BolA IbaG family
I6K62_RS25355	COG3056	Lipoprotein
I6K62_RS25360	COG2223	nitrite transmembrane transporter activity
I6K62_RS25365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K62_RS25370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K62_RS25375	COG1845	cytochrome c oxidase, subunit III
I6K62_RS25380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K62_RS25395	COG1414	Transcriptional regulator
I6K62_RS25400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K62_RS25405	COG1053	succinate dehydrogenase
I6K62_RS25415	COG1053	succinate dehydrogenase
I6K62_RS25430	COG2211	Major facilitator Superfamily
I6K62_RS25435	COG0673	inositol 2-dehydrogenase activity
I6K62_RS25440	COG2814	Major facilitator Superfamily
I6K62_RS25495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K62_RS25500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6K62_RS25510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6K62_RS25520	COG0736	holo-[acyl-carrier-protein] synthase activity
I6K62_RS25525	COG2831	hemolysin activation secretion protein
I6K62_RS25540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K62_RS25565	COG0142	geranyltranstransferase activity
I6K62_RS25575	COG0667	Aldo Keto reductase
I6K62_RS25580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K62_RS25585	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K62_RS25600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K62_RS25600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K62_RS25610	COG4238	major outer membrane lipoprotein
I6K62_RS25635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K62_RS25640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K62_RS25645	COG1862	Preprotein translocase
I6K62_RS25660	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6K62_RS25665	COG0450	alkyl hydroperoxide reductase
I6K62_RS25670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS25685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K62_RS25695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6K62_RS25705	COG1335	isochorismatase
I6K62_RS25710	COG0583	DNA-binding transcription factor activity
I6K62_RS25715	COG0366	Alpha amylase catalytic
I6K62_RS25740	COG0420	3'-5' exonuclease activity
I6K62_RS25745	COG0419	ATPase involved in DNA repair
I6K62_RS25755	COG1940	carbohydrate kinase activity
I6K62_RS25770	COG4126	flavin adenine dinucleotide binding
I6K62_RS25780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K62_RS25785	COG3416	Protein conserved in bacteria
I6K62_RS25795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K62_RS25805	COG1785	Belongs to the alkaline phosphatase family
I6K62_RS25815	COG1609	Transcriptional regulator
I6K62_RS25825	COG1028	Short-chain dehydrogenase reductase Sdr
I6K62_RS25860	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K62_RS25870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K62_RS25875	COG0113	porphobilinogen synthase activity
I6K62_RS25880	COG1943	Transposase
I6K62_RS25890	COG2175	clavaminate synthase activity
I6K62_RS25900	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K62_RS25905	COG4521	taurine ABC transporter
I6K62_RS25920	COG2271	Major facilitator Superfamily
I6K62_RS25925	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K62_RS25935	COG3842	ATPase activity
I6K62_RS25940	COG2040	homocysteine
I6K62_RS25945	COG0833	amino acid
I6K62_RS25950	COG5434	Belongs to the glycosyl hydrolase 28 family
I6K62_RS25960	COG4303	Ethanolamine ammonia lyase large subunit
I6K62_RS25965	COG4302	ethanolamine ammonia-lyase activity
I6K62_RS26000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS26010	COG0765	amino acid transport
I6K62_RS26015	COG0765	amino acid transport
I6K62_RS26035	COG3188	usher protein
I6K62_RS26060	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K62_RS26070	COG3639	organic phosphonate transmembrane transporter activity
I6K62_RS26105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K62_RS26110	COG0583	DNA-binding transcription factor activity
I6K62_RS26115	COG0791	NLP P60 protein
I6K62_RS26120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K62_RS26125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6K62_RS26130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6K62_RS26165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K62_RS26175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K62_RS26185	COG0477	Major facilitator Superfamily
I6K62_RS26195	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K62_RS26200	COG3153	acetyltransferase
I6K62_RS26215	COG0246	Mannitol dehydrogenase
I6K62_RS26220	COG2186	Transcriptional regulator
I6K62_RS26240	COG1012	belongs to the aldehyde dehydrogenase family
I6K62_RS26245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K62_RS26255	COG1596	polysaccharide export
I6K62_RS26275	COG0463	Glycosyl transferase, family 2
I6K62_RS26280	COG0438	transferase activity, transferring glycosyl groups
I6K62_RS26285	COG0297	glycogen (starch) synthase activity
I6K62_RS26285	COG0438	transferase activity, transferring glycosyl groups
I6K62_RS26300	COG1045	serine acetyltransferase
I6K62_RS26320	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K62_RS26325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K62_RS26330	COG1690	Belongs to the RtcB family
I6K62_RS26335	COG0454	-acetyltransferase
I6K62_RS26350	COG2991	Protein conserved in bacteria
I6K62_RS26365	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K62_RS26370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K62_RS26385	COG3034	peptidoglycan biosynthetic process
I6K62_RS26390	COG0121	glutamine amidotransferase
I6K62_RS26400	COG1960	acyl-CoA dehydrogenase activity
I6K62_RS26405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K62_RS26425	COG2226	methyltransferase
I6K62_RS26435	COG0741	lytic transglycosylase activity
I6K62_RS26435	COG1388	LysM domain
I6K62_RS26440	COG2226	methyltransferase
I6K62_RS26450	COG2814	Major facilitator Superfamily
I6K62_RS26455	COG0583	DNA-binding transcription factor activity
I6K62_RS26530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K62_RS26540	COG2011	ABC-type metal ion transport system permease component
I6K62_RS26545	COG1464	Belongs to the NlpA lipoprotein family
I6K62_RS26555	COG1720	tRNA m6t6A37 methyltransferase activity
I6K62_RS26565	COG0791	NLP P60 protein
I6K62_RS26570	COG3015	lipoprotein NlpE involved in copper resistance
I6K62_RS26575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K62_RS26590	COG4568	rho-dependent transcription termination
I6K62_RS26600	COG0346	lactoylglutathione lyase activity
I6K62_RS26605	COG1982	Orn Lys Arg decarboxylase major
I6K62_RS26645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K62_RS26650	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K62_RS26665	COG0575	Belongs to the CDS family
I6K62_RS26670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K62_RS26675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K62_RS26690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6K62_RS26700	COG0024	Methionine aminopeptidase
I6K62_RS26705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K62_RS26725	COG3835	regulator
I6K62_RS26730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K62_RS26750	COG2860	membrane
I6K62_RS26775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K62_RS26780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K62_RS26785	COG1120	ATPase activity
I6K62_RS26790	COG4774	siderophore transport
I6K62_RS26795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K62_RS26880	COG1643	Atp-dependent helicase
I6K62_RS26885	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K62_RS26905	COG0617	tRNA 3'-terminal CCA addition
I6K62_RS26910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K62_RS26930	COG3539	Fimbrial protein
I6K62_RS26935	COG3121	Chaperone
I6K62_RS26940	COG3188	usher protein
I6K62_RS26965	COG0726	polysaccharide deacetylase
I6K62_RS26970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS26975	COG0842	Transport permease protein
I6K62_RS26980	COG1131	(ABC) transporter
I6K62_RS26985	COG0288	reversible hydration of carbon dioxide
I6K62_RS26995	COG4993	Dehydrogenase
I6K62_RS27005	COG2132	Multicopper oxidase
I6K62_RS27025	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K62_RS27050	COG3064	Membrane
I6K62_RS27065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K62_RS27070	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K62_RS27075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K62_RS27080	COG2186	Transcriptional regulator
I6K62_RS27090	COG1196	nuclear chromosome segregation
I6K62_RS27150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K62_RS27180	COG2198	Histidine kinase
I6K62_RS27180	COG0784	Response regulator, receiver
I6K62_RS27180	COG2205	protein histidine kinase activity
I6K62_RS27180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K62_RS27185	COG0745	RESPONSE REGULATOR receiver
I6K62_RS27195	COG4372	Transposase
I6K62_RS27200	COG3436	PFAM IS66 Orf2 family protein
I6K62_RS27225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K62_RS27245	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K62_RS27250	COG5297	Belongs to the glycosyl hydrolase family 6
I6K62_RS27250	COG2273	Hydrolase Family 16
I6K62_RS27255	COG1609	Transcriptional regulator
I6K62_RS27270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS27275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K62_RS27280	COG2723	6-phospho-beta-galactosidase activity
I6K62_RS27285	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K62_RS27325	COG2205	protein histidine kinase activity
I6K62_RS27330	COG0745	RESPONSE REGULATOR receiver
I6K62_RS27335	COG1276	copper resistance
I6K62_RS27340	COG2372	response to copper ion
I6K62_RS27345	COG3667	copper resistance
I6K62_RS27350	COG2132	Multicopper oxidase
I6K62_RS27360	COG0739	heme binding
I6K62_RS27390	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K62_RS27515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K62_RS27535	COG2267	carboxylic ester hydrolase activity
I6K62_RS27545	COG4962	Type ii secretion system protein e
I6K62_RS27550	COG3838	Conjugal transfer protein Trbc
I6K62_RS27560	COG3451	type IV secretory pathway VirB4
I6K62_RS27575	COG3846	protein secretion by the type IV secretion system
I6K62_RS27595	COG2948	multi-organism process
I6K62_RS27680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K62_RS27710	COG0789	Transcriptional regulator
I6K62_RS27750	COG0789	Transcriptional regulator
I6K62_RS27785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K62_RS27850	COG0741	lytic transglycosylase activity
I6K62_RS27875	COG0741	lytic transglycosylase activity
I6K62_RS27980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K62_RS28020	COG3655	Transcriptional regulator
I6K62_RS28035	COG3121	Chaperone
I6K62_RS28060	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K62_RS28115	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K62_RS28115	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K62_RS28125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K62_RS28140	COG2022	thiamine diphosphate biosynthetic process
I6K62_RS28145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K62_RS28150	COG1349	DNA-binding transcription factor activity