locus-tag	class	description
I6K63_RS00015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K63_RS00035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K63_RS00040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K63_RS00065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS00075	COG1397	ADP-ribosylglycohydrolase
I6K63_RS00085	COG1811	Na channel or pump
I6K63_RS00095	COG0583	DNA-binding transcription factor activity
I6K63_RS00110	COG3118	belongs to the thioredoxin family
I6K63_RS00115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K63_RS00120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K63_RS00130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K63_RS00135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K63_RS00140	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K63_RS00145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K63_RS00150	COG0456	acetyltransferase
I6K63_RS00155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K63_RS00160	COG2244	polysaccharide biosynthetic process
I6K63_RS00205	COG3071	HemY protein
I6K63_RS00210	COG2959	enzyme of heme biosynthesis
I6K63_RS00215	COG1587	Uroporphyrinogen-III synthase
I6K63_RS00225	COG3072	Adenylate cyclase
I6K63_RS00235	COG5567	small periplasmic lipoprotein
I6K63_RS00255	COG1011	Hydrolase
I6K63_RS00260	COG0210	DNA helicase
I6K63_RS00265	COG0598	Magnesium transport protein CorA
I6K63_RS00275	COG2050	protein possibly involved in aromatic compounds catabolism
I6K63_RS00290	COG1280	lysine exporter protein (LysE YggA)
I6K63_RS00300	COG1280	lysine exporter protein (LysE YggA)
I6K63_RS00305	COG2267	carboxylic ester hydrolase activity
I6K63_RS00310	COG0561	phosphatase activity
I6K63_RS00315	COG0697	spore germination
I6K63_RS00320	COG0583	DNA-binding transcription factor activity
I6K63_RS00330	COG1263	PTS System
I6K63_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS00335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6K63_RS00340	COG2188	Transcriptional regulator
I6K63_RS00345	COG0641	radical SAM
I6K63_RS00375	COG3165	ubiquinone biosynthetic process from chorismate
I6K63_RS00395	COG0805	protein transport
I6K63_RS00440	COG1739	Uncharacterized protein family UPF0029
I6K63_RS00450	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K63_RS00480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K63_RS00520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K63_RS00525	COG0250	Participates in transcription elongation, termination and antitermination
I6K63_RS00560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K63_RS00565	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K63_RS00575	COG3706	GGDEF domain
I6K63_RS00580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K63_RS00590	COG2104	thiamine diphosphate biosynthetic process
I6K63_RS00595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K63_RS00610	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K63_RS00650	COG4191	Histidine kinase
I6K63_RS00660	COG0151	Belongs to the GarS family
I6K63_RS00700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K63_RS00740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K63_RS00780	COG1187	pseudouridine synthase activity
I6K63_RS00800	COG4650	regulator
I6K63_RS00810	COG0330	HflC and HflK could
I6K63_RS00815	COG3541	Predicted nucleotidyltransferase
I6K63_RS00825	COG0527	aspartate kinase activity
I6K63_RS00835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K63_RS00870	COG0477	Major facilitator Superfamily
I6K63_RS00870	COG2814	Major facilitator Superfamily
I6K63_RS00920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K63_RS00930	COG0534	Mate efflux family protein
I6K63_RS00935	COG3237	CsbD-like
I6K63_RS00940	COG0735	belongs to the Fur family
I6K63_RS00950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K63_RS00965	COG0305	Participates in initiation and elongation during chromosome replication
I6K63_RS00970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K63_RS00980	COG1448	Aminotransferase
I6K63_RS00990	COG0432	Pfam Uncharacterised protein family UPF0047
I6K63_RS00995	COG2315	Protein conserved in bacteria
I6K63_RS01015	COG0629	single-stranded DNA binding
I6K63_RS01020	COG0741	lytic transglycosylase activity
I6K63_RS01025	COG4771	TonB-dependent receptor
I6K63_RS01035	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K63_RS01050	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K63_RS01070	COG2252	PERMEase
I6K63_RS01075	COG0025	NhaP-type Na H and K H
I6K63_RS01080	COG0583	DNA-binding transcription factor activity
I6K63_RS01125	COG3162	membrane
I6K63_RS01130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K63_RS01135	COG1301	dicarboxylic acid transport
I6K63_RS01140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K63_RS01150	COG1940	carbohydrate kinase activity
I6K63_RS01155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K63_RS01160	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS01165	COG1129	ABC transporter
I6K63_RS01170	COG1879	ABC-type sugar transport system periplasmic component
I6K63_RS01175	COG1737	Transcriptional regulator
I6K63_RS01180	COG0698	ribose 5-phosphate isomerase
I6K63_RS01210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K63_RS01215	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6K63_RS01220	COG3454	Phosphonate metabolism
I6K63_RS01225	COG4778	phosphonate C-P lyase system protein PhnL
I6K63_RS01230	COG4107	phosphonate C-P lyase system protein PhnK
I6K63_RS01235	COG3627	carbon phosphorus lyase activity
I6K63_RS01240	COG3626	phosphonate metabolism
I6K63_RS01245	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K63_RS01250	COG3624	Phosphonate C-P lyase system protein PhnG
I6K63_RS01255	COG2188	Transcriptional regulator
I6K63_RS01260	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K63_RS01265	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K63_RS01275	COG2169	Transcriptional regulator
I6K63_RS01295	COG0861	Integral membrane protein TerC family
I6K63_RS01310	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K63_RS01325	COG1309	transcriptional regulator
I6K63_RS01340	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K63_RS01345	COG1027	Aspartate ammonia-lyase
I6K63_RS01350	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K63_RS01355	COG0531	amino acid
I6K63_RS01365	COG0459	protein refolding
I6K63_RS01405	COG3121	Chaperone
I6K63_RS01420	COG1509	lysine 2,3-aminomutase activity
I6K63_RS01435	COG5510	response to toxic substance
I6K63_RS01440	COG2076	Multidrug Resistance protein
I6K63_RS01445	COG3040	lipid binding
I6K63_RS01460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K63_RS01465	COG1053	succinate dehydrogenase
I6K63_RS01475	COG3264	Mechanosensitive ion channel
I6K63_RS01475	COG1511	domain protein
I6K63_RS01490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6K63_RS01495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS01515	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K63_RS01520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K63_RS01520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K63_RS01525	COG0802	atpase or kinase
I6K63_RS01530	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K63_RS01550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K63_RS01555	COG0330	HflC and HflK could
I6K63_RS01560	COG0330	HflC and HflK could
I6K63_RS01565	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K63_RS01580	COG0557	exoribonuclease II activity
I6K63_RS01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K63_RS01595	COG1960	acyl-CoA dehydrogenase activity
I6K63_RS01605	COG3650	response to hydrogen peroxide
I6K63_RS01610	COG1073	alpha beta
I6K63_RS01670	COG2965	DNA replication, synthesis of RNA primer
I6K63_RS01675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K63_RS01680	COG0359	binds to the 23S rRNA
I6K63_RS01690	COG3061	Opacity-associated protein A
I6K63_RS01695	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K63_RS01700	COG1113	amino acid transport
I6K63_RS01710	COG0697	spore germination
I6K63_RS01720	COG0702	epimerase
I6K63_RS01725	COG1733	regulation of RNA biosynthetic process
I6K63_RS01740	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K63_RS01750	COG1253	flavin adenine dinucleotide binding
I6K63_RS01760	COG0729	surface antigen
I6K63_RS01765	COG2911	Protein conserved in bacteria
I6K63_RS01770	COG2105	PFAM AIG2 family protein
I6K63_RS01780	COG1879	ABC-type sugar transport system periplasmic component
I6K63_RS01785	COG1129	ABC transporter
I6K63_RS01790	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS01795	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS01810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K63_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS01835	COG1454	alcohol dehydrogenase
I6K63_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS01845	COG0312	modulator of DNA gyrase
I6K63_RS01880	COG3964	amidohydrolase
I6K63_RS01895	COG2706	6-phosphogluconolactonase activity
I6K63_RS01900	COG3711	transcriptional antiterminator
I6K63_RS01900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS01905	COG0602	queuosine metabolic process
I6K63_RS01925	COG1486	melibiose metabolic process
I6K63_RS01930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS01935	COG0366	Alpha amylase catalytic
I6K63_RS01940	COG1263	PTS System
I6K63_RS01940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS01945	COG1609	Transcriptional regulator
I6K63_RS01960	COG0251	oxidation-reduction process
I6K63_RS01965	COG3397	chitin binding
I6K63_RS01990	COG2731	YhcH YjgK YiaL family protein
I6K63_RS01995	COG2222	sugar isomerase
I6K63_RS02000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS02005	COG1228	amidohydrolase
I6K63_RS02010	COG1288	antiporter activity
I6K63_RS02015	COG2188	Transcriptional regulator
I6K63_RS02020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K63_RS02045	COG0525	valine-tRNA ligase activity
I6K63_RS02050	COG2927	DNA polymerase III (CHI subunit)
I6K63_RS02060	COG0795	lipopolysaccharide-transporting ATPase activity
I6K63_RS02065	COG0795	lipopolysaccharide-transporting ATPase activity
I6K63_RS02070	COG0433	COG0433 Predicted ATPase
I6K63_RS02085	COG3718	enzyme involved in inositol metabolism
I6K63_RS02090	COG0837	glucose binding
I6K63_RS02090	COG1737	Transcriptional regulator
I6K63_RS02095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS02100	COG3962	Belongs to the TPP enzyme family
I6K63_RS02110	COG1082	Xylose isomerase domain protein TIM barrel
I6K63_RS02120	COG2814	Major facilitator Superfamily
I6K63_RS02130	COG3842	ATPase activity
I6K63_RS02135	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K63_RS02140	COG0395	ABC-type sugar transport system, permease component
I6K63_RS02145	COG1175	transmembrane transport
I6K63_RS02150	COG1064	alcohol dehydrogenase
I6K63_RS02160	COG0582	viral genome integration into host DNA
I6K63_RS02180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K63_RS02230	COG3596	GTP binding
I6K63_RS02260	COG2003	Belongs to the UPF0758 family
I6K63_RS02315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K63_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS02325	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS02330	COG0477	Major facilitator Superfamily
I6K63_RS02340	COG0477	Major facilitator Superfamily
I6K63_RS02355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6K63_RS02360	COG2850	peptidyl-arginine hydroxylation
I6K63_RS02390	COG0842	Transport permease protein
I6K63_RS02395	COG0842	Transport permease protein
I6K63_RS02395	COG1129	ABC transporter
I6K63_RS02400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS02405	COG3706	GGDEF domain
I6K63_RS02415	COG0814	amino acid
I6K63_RS02445	COG4869	propanediol catabolic process
I6K63_RS02455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K63_RS02460	COG1882	Formate acetyltransferase
I6K63_RS02475	COG1454	alcohol dehydrogenase
I6K63_RS02475	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS02510	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K63_RS02525	COG0531	amino acid
I6K63_RS02535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K63_RS02540	COG5457	Domain of unknown function (DUF1127)
I6K63_RS02550	COG1566	PFAM secretion protein HlyD family protein
I6K63_RS02560	COG0583	DNA-binding transcription factor activity
I6K63_RS02565	COG3366	ferrous iron transmembrane transporter activity
I6K63_RS02570	COG0700	Nucleoside recognition
I6K63_RS02575	COG1473	amidohydrolase
I6K63_RS02585	COG1924	4 iron, 4 sulfur cluster binding
I6K63_RS02590	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K63_RS02600	COG3969	phosphoadenosine phosphosulfate
I6K63_RS02605	COG1475	DNA binding
I6K63_RS02610	COG2814	Major facilitator Superfamily
I6K63_RS02615	COG2733	membrane
I6K63_RS02635	COG5464	transposase or invertase
I6K63_RS02640	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS02645	COG0523	cobalamin synthesis protein
I6K63_RS02650	COG2879	small protein
I6K63_RS02655	COG1966	Carbon starvation protein
I6K63_RS02660	COG2831	hemolysin activation secretion protein
I6K63_RS02665	COG3210	domain, Protein
I6K63_RS02680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K63_RS02685	COG2368	4-hydroxyphenylacetate
I6K63_RS02705	COG3971	2-oxopent-4-enoate hydratase activity
I6K63_RS02715	COG3384	dioxygenase
I6K63_RS02720	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS02730	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K63_RS02735	COG1846	Transcriptional regulator
I6K63_RS02745	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K63_RS02755	COG4145	pantothenate transmembrane transporter activity
I6K63_RS02760	COG3734	2-keto-3-deoxy-galactonokinase
I6K63_RS02765	COG0800	Aldolase
I6K63_RS02770	COG1737	Transcriptional regulator
I6K63_RS02780	COG0456	acetyltransferase
I6K63_RS02780	COG1214	PFAM Peptidase M22, glycoprotease
I6K63_RS02785	COG2271	Major facilitator Superfamily
I6K63_RS02790	COG1802	Transcriptional regulator
I6K63_RS02795	COG1063	alcohol dehydrogenase
I6K63_RS02805	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K63_RS02805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K63_RS02820	COG3715	PTS system
I6K63_RS02825	COG3716	PTS system mannose fructose sorbose family IID component
I6K63_RS02830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K63_RS02840	COG5464	transposase or invertase
I6K63_RS02855	COG1484	DNA-dependent DNA replication
I6K63_RS02870	COG2966	Psort location CytoplasmicMembrane, score
I6K63_RS02880	COG2207	Transcriptional regulator
I6K63_RS02885	COG2197	response regulator
I6K63_RS02890	COG2197	response regulator
I6K63_RS02895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K63_RS02900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS02905	COG4114	ferric iron reductase
I6K63_RS02910	COG3706	GGDEF domain
I6K63_RS02940	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K63_RS02945	COG0456	acetyltransferase
I6K63_RS02950	COG1011	Hydrolase
I6K63_RS02960	COG2823	Periplasmic or secreted lipoprotein
I6K63_RS02965	COG5487	UPF0391 membrane protein
I6K63_RS02970	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K63_RS02975	COG0084	hydrolase, TatD family'
I6K63_RS02980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K63_RS03000	COG0813	purine-nucleoside phosphorylase activity
I6K63_RS03010	COG3726	membrane protein affecting hemolysin expression
I6K63_RS03015	COG0560	Phosphoserine phosphatase
I6K63_RS03030	COG0488	(ABC) transporter
I6K63_RS03035	COG0741	lytic transglycosylase activity
I6K63_RS03055	COG3708	Transcriptional regulator
I6K63_RS03055	COG2207	Transcriptional regulator
I6K63_RS03060	COG3045	CreA protein
I6K63_RS03065	COG0745	RESPONSE REGULATOR receiver
I6K63_RS03070	COG2205	protein histidine kinase activity
I6K63_RS03075	COG4452	Inner membrane protein CreD
I6K63_RS03080	COG0745	RESPONSE REGULATOR receiver
I6K63_RS03090	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K63_RS03100	COG0460	homoserine dehydrogenase
I6K63_RS03100	COG0527	aspartate kinase activity
I6K63_RS03110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K63_RS03120	COG1115	amino acid carrier protein
I6K63_RS03125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K63_RS03130	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K63_RS03135	COG0477	Major facilitator Superfamily
I6K63_RS03140	COG1584	GPR1 FUN34 yaaH family protein
I6K63_RS03145	COG4735	regulation of single-species biofilm formation
I6K63_RS03200	COG3539	Fimbrial protein
I6K63_RS03210	COG3188	usher protein
I6K63_RS03220	COG3539	Fimbrial protein
I6K63_RS03225	COG3539	Fimbrial protein
I6K63_RS03230	COG3121	Chaperone
I6K63_RS03245	COG3119	arylsulfatase activity
I6K63_RS03260	COG0583	DNA-binding transcription factor activity
I6K63_RS03270	COG0196	riboflavin kinase activity
I6K63_RS03285	COG1047	Peptidyl-prolyl cis-trans
I6K63_RS03300	COG0583	DNA-binding transcription factor activity
I6K63_RS03305	COG2828	Protein conserved in bacteria
I6K63_RS03310	COG0471	metal ion transport
I6K63_RS03315	COG0471	metal ion transport
I6K63_RS03320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K63_RS03330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K63_RS03345	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6K63_RS03350	COG5016	pyruvate
I6K63_RS03350	COG0511	ligase activity, forming carbon-carbon bonds
I6K63_RS03460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K63_RS03475	COG3493	citrate carrier protein
I6K63_RS03485	COG0564	pseudouridine synthase activity
I6K63_RS03495	COG0417	DNA replication proofreading
I6K63_RS03505	COG0235	Class ii aldolase
I6K63_RS03525	COG0586	Pfam SNARE associated Golgi protein
I6K63_RS03535	COG1178	ABC-type Fe3 transport system permease component
I6K63_RS03555	COG2814	Major facilitator Superfamily
I6K63_RS03560	COG2271	Major facilitator Superfamily
I6K63_RS03565	COG0583	DNA-binding transcription factor activity
I6K63_RS03575	COG0738	Major facilitator superfamily
I6K63_RS03580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K63_RS03605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K63_RS03620	COG0028	Belongs to the TPP enzyme family
I6K63_RS03630	COG1609	Transcriptional regulator
I6K63_RS03650	COG0768	penicillin binding
I6K63_RS03655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K63_RS03660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K63_RS03675	COG0772	Belongs to the SEDS family
I6K63_RS03700	COG0849	cell division
I6K63_RS03705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K63_RS03725	COG0494	nUDIX hydrolase
I6K63_RS03730	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6K63_RS03750	COG1459	type II secretion system
I6K63_RS03755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K63_RS03760	COG4969	Belongs to the N-Me-Phe pilin family
I6K63_RS03775	COG3725	Membrane protein required for beta-lactamase induction
I6K63_RS03780	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K63_RS03785	COG2211	Major facilitator Superfamily
I6K63_RS03790	COG1113	amino acid transport
I6K63_RS03795	COG2186	Transcriptional regulator
I6K63_RS03800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K63_RS03805	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K63_RS03810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K63_RS03825	COG3064	Membrane
I6K63_RS03850	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K63_RS03865	COG2132	Multicopper oxidase
I6K63_RS03875	COG4993	Dehydrogenase
I6K63_RS03885	COG0288	reversible hydration of carbon dioxide
I6K63_RS03890	COG1131	(ABC) transporter
I6K63_RS03895	COG0842	Transport permease protein
I6K63_RS03900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS03905	COG0726	polysaccharide deacetylase
I6K63_RS03930	COG3188	usher protein
I6K63_RS03935	COG3121	Chaperone
I6K63_RS03940	COG3539	Fimbrial protein
I6K63_RS03960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K63_RS03965	COG0617	tRNA 3'-terminal CCA addition
I6K63_RS03985	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K63_RS03990	COG1643	Atp-dependent helicase
I6K63_RS04075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K63_RS04080	COG4774	siderophore transport
I6K63_RS04085	COG1120	ATPase activity
I6K63_RS04090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K63_RS04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS04120	COG2860	membrane
I6K63_RS04140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K63_RS04145	COG3835	regulator
I6K63_RS04165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K63_RS04170	COG0024	Methionine aminopeptidase
I6K63_RS04180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6K63_RS04195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K63_RS04200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K63_RS04205	COG0575	Belongs to the CDS family
I6K63_RS04220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K63_RS04225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K63_RS04265	COG1982	Orn Lys Arg decarboxylase major
I6K63_RS04270	COG0346	lactoylglutathione lyase activity
I6K63_RS04280	COG4568	rho-dependent transcription termination
I6K63_RS04295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K63_RS04300	COG3015	lipoprotein NlpE involved in copper resistance
I6K63_RS04305	COG0791	NLP P60 protein
I6K63_RS04315	COG1720	tRNA m6t6A37 methyltransferase activity
I6K63_RS04325	COG1464	Belongs to the NlpA lipoprotein family
I6K63_RS04330	COG2011	ABC-type metal ion transport system permease component
I6K63_RS04340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K63_RS04415	COG0583	DNA-binding transcription factor activity
I6K63_RS04420	COG2814	Major facilitator Superfamily
I6K63_RS04430	COG2226	methyltransferase
I6K63_RS04435	COG1388	LysM domain
I6K63_RS04435	COG0741	lytic transglycosylase activity
I6K63_RS04445	COG2226	methyltransferase
I6K63_RS04465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K63_RS04470	COG1960	acyl-CoA dehydrogenase activity
I6K63_RS04480	COG0121	glutamine amidotransferase
I6K63_RS04485	COG3034	peptidoglycan biosynthetic process
I6K63_RS04500	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K63_RS04505	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K63_RS04520	COG2991	Protein conserved in bacteria
I6K63_RS04535	COG0454	-acetyltransferase
I6K63_RS04540	COG1690	Belongs to the RtcB family
I6K63_RS04545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K63_RS04550	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K63_RS04570	COG1045	serine acetyltransferase
I6K63_RS04585	COG0438	transferase activity, transferring glycosyl groups
I6K63_RS04585	COG0297	glycogen (starch) synthase activity
I6K63_RS04590	COG0438	transferase activity, transferring glycosyl groups
I6K63_RS04595	COG0463	Glycosyl transferase, family 2
I6K63_RS04615	COG1596	polysaccharide export
I6K63_RS04625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K63_RS04630	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS04650	COG2186	Transcriptional regulator
I6K63_RS04655	COG0246	Mannitol dehydrogenase
I6K63_RS04670	COG3153	acetyltransferase
I6K63_RS04675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K63_RS04685	COG0477	Major facilitator Superfamily
I6K63_RS04695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K63_RS04705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K63_RS04740	COG2003	Belongs to the UPF0758 family
I6K63_RS04755	COG3596	GTP binding
I6K63_RS04780	COG0431	NADPH-dependent FMN reductase
I6K63_RS04810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K63_RS04835	COG1196	nuclear chromosome segregation
I6K63_RS04855	COG0582	viral genome integration into host DNA
I6K63_RS04865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6K63_RS04870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6K63_RS04875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K63_RS04880	COG0791	NLP P60 protein
I6K63_RS04885	COG0583	DNA-binding transcription factor activity
I6K63_RS04890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K63_RS04925	COG3639	organic phosphonate transmembrane transporter activity
I6K63_RS04935	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K63_RS04960	COG3188	usher protein
I6K63_RS04980	COG0765	amino acid transport
I6K63_RS04985	COG0765	amino acid transport
I6K63_RS04995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS05030	COG4302	ethanolamine ammonia-lyase activity
I6K63_RS05035	COG4303	Ethanolamine ammonia lyase large subunit
I6K63_RS05045	COG5434	Belongs to the glycosyl hydrolase 28 family
I6K63_RS05050	COG0833	amino acid
I6K63_RS05055	COG2040	homocysteine
I6K63_RS05060	COG3842	ATPase activity
I6K63_RS05070	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K63_RS05075	COG2271	Major facilitator Superfamily
I6K63_RS05090	COG4521	taurine ABC transporter
I6K63_RS05095	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K63_RS05100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K63_RS05105	COG2175	clavaminate synthase activity
I6K63_RS05115	COG1943	Transposase
I6K63_RS05120	COG0113	porphobilinogen synthase activity
I6K63_RS05125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K63_RS05135	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K63_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS05180	COG1609	Transcriptional regulator
I6K63_RS05190	COG1785	Belongs to the alkaline phosphatase family
I6K63_RS05200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K63_RS05210	COG3416	Protein conserved in bacteria
I6K63_RS05215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K63_RS05225	COG4126	flavin adenine dinucleotide binding
I6K63_RS05240	COG1940	carbohydrate kinase activity
I6K63_RS05250	COG0419	ATPase involved in DNA repair
I6K63_RS05255	COG0420	3'-5' exonuclease activity
I6K63_RS05280	COG0366	Alpha amylase catalytic
I6K63_RS05285	COG0583	DNA-binding transcription factor activity
I6K63_RS05290	COG1335	isochorismatase
I6K63_RS05300	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6K63_RS05310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS05325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS05330	COG0450	alkyl hydroperoxide reductase
I6K63_RS05335	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6K63_RS05350	COG1862	Preprotein translocase
I6K63_RS05355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K63_RS05360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K63_RS05385	COG4238	major outer membrane lipoprotein
I6K63_RS05395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K63_RS05395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K63_RS05410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K63_RS05415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K63_RS05420	COG0667	Aldo Keto reductase
I6K63_RS05430	COG0142	geranyltranstransferase activity
I6K63_RS05455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K63_RS05470	COG2831	hemolysin activation secretion protein
I6K63_RS05475	COG0736	holo-[acyl-carrier-protein] synthase activity
I6K63_RS05485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6K63_RS05490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K63_RS05495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6K63_RS05500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K63_RS05555	COG2814	Major facilitator Superfamily
I6K63_RS05560	COG0673	inositol 2-dehydrogenase activity
I6K63_RS05565	COG2211	Major facilitator Superfamily
I6K63_RS05580	COG1053	succinate dehydrogenase
I6K63_RS05590	COG1053	succinate dehydrogenase
I6K63_RS05595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K63_RS05600	COG1414	Transcriptional regulator
I6K63_RS05615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K63_RS05620	COG1845	cytochrome c oxidase, subunit III
I6K63_RS05625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K63_RS05630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K63_RS05635	COG2223	nitrite transmembrane transporter activity
I6K63_RS05640	COG3056	Lipoprotein
I6K63_RS05645	COG0271	Belongs to the BolA IbaG family
I6K63_RS05665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K63_RS05670	COG0776	regulation of translation
I6K63_RS05675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K63_RS05680	COG1555	photosystem II stabilization
I6K63_RS05685	COG0824	Thioesterase
I6K63_RS05695	COG4533	DNA binding
I6K63_RS05710	COG1522	sequence-specific DNA binding
I6K63_RS05715	COG1132	(ABC) transporter
I6K63_RS05720	COG1132	(ABC) transporter
I6K63_RS05725	COG0347	Belongs to the P(II) protein family
I6K63_RS05730	COG0004	ammonium transporteR
I6K63_RS05735	COG1811	Na channel or pump
I6K63_RS05740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K63_RS05745	COG0583	DNA-binding transcription factor activity
I6K63_RS05750	COG1946	Acyl-CoA thioesterase
I6K63_RS05755	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K63_RS05760	COG3695	enzyme binding
I6K63_RS05785	COG2364	Membrane
I6K63_RS05790	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K63_RS05805	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K63_RS05815	COG2182	Extracellular solute-binding protein
I6K63_RS05820	COG1175	transmembrane transport
I6K63_RS05825	COG3833	ABC-type maltose transport systems, permease component
I6K63_RS05830	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K63_RS05835	COG1874	Beta-galactosidase
I6K63_RS05840	COG1263	PTS System
I6K63_RS05840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS05860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6K63_RS05880	COG0110	maltose O-acetyltransferase activity
I6K63_RS05895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K63_RS05900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS05905	COG1309	transcriptional regulator
I6K63_RS05910	COG1196	nuclear chromosome segregation
I6K63_RS05910	COG3264	Mechanosensitive ion channel
I6K63_RS05925	COG3923	Primosomal replication protein n
I6K63_RS05930	COG2832	Protein of unknown function (DUF454)
I6K63_RS05940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K63_RS05970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS05975	COG4651	solute:proton antiporter activity
I6K63_RS05975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K63_RS05980	COG2223	nitrite transmembrane transporter activity
I6K63_RS05990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K63_RS05995	COG3735	TraB family
I6K63_RS06010	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K63_RS06015	COG0330	HflC and HflK could
I6K63_RS06020	COG4619	ABC transporter
I6K63_RS06025	COG0390	transport system, permease component
I6K63_RS06030	COG3118	belongs to the thioredoxin family
I6K63_RS06035	COG0300	oxidoreductase activity
I6K63_RS06040	COG2755	lipolytic protein G-D-S-L family
I6K63_RS06045	COG4181	ATPase activity
I6K63_RS06050	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K63_RS06085	COG3960	tartronate-semialdehyde synthase activity
I6K63_RS06090	COG3622	Belongs to the hyi family
I6K63_RS06095	COG2084	Dehydrogenase
I6K63_RS06105	COG1953	Uracil, thiamine, allantoin
I6K63_RS06115	COG2233	PERMEase
I6K63_RS06120	COG1929	Belongs to the glycerate kinase type-1 family
I6K63_RS06125	COG3257	ureidoglycine aminohydrolase activity
I6K63_RS06130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K63_RS06135	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K63_RS06140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K63_RS06145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K63_RS06155	COG0549	Belongs to the carbamate kinase family
I6K63_RS06160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K63_RS06165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K63_RS06180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K63_RS06190	COG2501	S4 domain
I6K63_RS06225	COG2211	Major facilitator Superfamily
I6K63_RS06230	COG1285	pathogenesis
I6K63_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K63_RS06265	COG0583	DNA-binding transcription factor activity
I6K63_RS06275	COG3710	Transcriptional regulator
I6K63_RS06280	COG0531	amino acid
I6K63_RS06290	COG3104	oligopeptide transport
I6K63_RS06315	COG0673	inositol 2-dehydrogenase activity
I6K63_RS06330	COG1129	ABC transporter
I6K63_RS06335	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS06375	COG0583	DNA-binding transcription factor activity
I6K63_RS06380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS06380	COG2190	(PTS) system
I6K63_RS06380	COG1263	PTS System
I6K63_RS06385	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS06390	COG3711	transcriptional antiterminator
I6K63_RS06430	COG3121	Chaperone
I6K63_RS06440	COG3188	usher protein
I6K63_RS06445	COG3121	Chaperone
I6K63_RS06450	COG3539	Fimbrial protein
I6K63_RS06455	COG1473	amidohydrolase
I6K63_RS06460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS06465	COG0667	Aldo Keto reductase
I6K63_RS06480	COG1113	amino acid transport
I6K63_RS06485	COG2211	Major facilitator Superfamily
I6K63_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS06510	COG0583	DNA-binding transcription factor activity
I6K63_RS06515	COG2771	luxR family
I6K63_RS06530	COG3188	usher protein
I6K63_RS06550	COG0494	nUDIX hydrolase
I6K63_RS06560	COG0668	transmembrane transport
I6K63_RS06565	COG0477	Major facilitator Superfamily
I6K63_RS06580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K63_RS06580	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K63_RS06585	COG2222	sugar isomerase
I6K63_RS06590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K63_RS06595	COG3716	PTS system mannose fructose sorbose family IID component
I6K63_RS06605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS06615	COG0778	Nitroreductase
I6K63_RS06620	COG2315	Protein conserved in bacteria
I6K63_RS06640	COG4774	siderophore transport
I6K63_RS06670	COG3698	Phosphodiester glycosidase
I6K63_RS06680	COG4166	transmembrane transport
I6K63_RS06690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K63_RS06695	COG4608	Belongs to the ABC transporter superfamily
I6K63_RS06700	COG0444	Belongs to the ABC transporter superfamily
I6K63_RS06705	COG0154	amidase activity
I6K63_RS06715	COG0697	spore germination
I6K63_RS06730	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K63_RS06735	COG0765	amino acid transport
I6K63_RS06740	COG0765	amino acid transport
I6K63_RS06750	COG4221	oxidoreductase activity
I6K63_RS06755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K63_RS06760	COG4172	Belongs to the ABC transporter superfamily
I6K63_RS06765	COG0444	Belongs to the ABC transporter superfamily
I6K63_RS06770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K63_RS06775	COG0601	transmembrane transport
I6K63_RS06780	COG0747	negative chemotaxis
I6K63_RS06805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K63_RS06815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K63_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS06830	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS06835	COG1129	ABC transporter
I6K63_RS06845	COG1879	ABC-type sugar transport system periplasmic component
I6K63_RS06850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K63_RS06855	COG2390	Transcriptional regulator
I6K63_RS06860	COG3959	Transketolase, thiamine diphosphate binding domain
I6K63_RS06865	COG3958	Transketolase
I6K63_RS06870	COG2977	Belongs to the P-Pant transferase superfamily
I6K63_RS06875	COG4771	TonB-dependent receptor
I6K63_RS06880	COG2382	esterase
I6K63_RS06885	COG3251	PFAM MbtH domain protein
I6K63_RS06890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K63_RS06890	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K63_RS06895	COG1120	ATPase activity
I6K63_RS06900	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS06905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS06920	COG4592	Periplasmic binding protein
I6K63_RS06925	COG1169	isochorismate synthase
I6K63_RS06930	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K63_RS06935	COG1535	isochorismatase
I6K63_RS06935	COG3433	isochorismatase activity
I6K63_RS06940	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS06950	COG1966	Carbon starvation protein
I6K63_RS06955	COG2879	small protein
I6K63_RS06965	COG0371	Dehydrogenase
I6K63_RS06970	COG1129	ABC transporter
I6K63_RS06975	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS07005	COG2271	Major facilitator Superfamily
I6K63_RS07010	COG0483	inositol monophosphate 1-phosphatase activity
I6K63_RS07020	COG0402	S-adenosylhomocysteine deaminase activity
I6K63_RS07030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K63_RS07045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K63_RS07055	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS07060	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS07065	COG1129	ABC transporter
I6K63_RS07080	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6K63_RS07085	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6K63_RS07090	COG0436	Aminotransferase
I6K63_RS07095	COG1475	DNA binding
I6K63_RS07100	COG3969	phosphoadenosine phosphosulfate
I6K63_RS07105	COG0583	DNA-binding transcription factor activity
I6K63_RS07110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K63_RS07120	COG3634	alkyl hydroperoxide reductase activity
I6K63_RS07130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K63_RS07135	COG3719	Belongs to the RNase T2 family
I6K63_RS07140	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K63_RS07160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K63_RS07165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K63_RS07175	COG0583	DNA-binding transcription factor activity
I6K63_RS07190	COG1686	Belongs to the peptidase S11 family
I6K63_RS07195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K63_RS07200	COG0772	Belongs to the SEDS family
I6K63_RS07205	COG0768	penicillin binding
I6K63_RS07215	COG0799	negative regulation of ribosome biogenesis
I6K63_RS07220	COG0406	alpha-ribazole phosphatase activity
I6K63_RS07230	COG1466	dna polymerase III delta subunit
I6K63_RS07245	COG2888	peptidyl-tyrosine sulfation
I6K63_RS07250	COG3210	domain, Protein
I6K63_RS07255	COG2831	hemolysin activation secretion protein
I6K63_RS07260	COG1126	abc transporter atp-binding protein
I6K63_RS07265	COG0765	amino acid transport
I6K63_RS07270	COG0765	amino acid transport
I6K63_RS07285	COG4535	Mg2 and Co2 transporter CorC
I6K63_RS07295	COG1702	phosphate starvation-inducible protein PhoH
I6K63_RS07305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K63_RS07345	COG0367	asparagine synthase
I6K63_RS07350	COG0647	UMP catabolic process
I6K63_RS07355	COG1940	carbohydrate kinase activity
I6K63_RS07355	COG1846	Transcriptional regulator
I6K63_RS07360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K63_RS07400	COG1053	succinate dehydrogenase
I6K63_RS07405	COG0583	DNA-binding transcription factor activity
I6K63_RS07410	COG0735	belongs to the Fur family
I6K63_RS07425	COG0596	Alpha beta hydrolase
I6K63_RS07430	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K63_RS07435	COG0033	Phosphoglucomutase
I6K63_RS07445	COG1349	DNA-binding transcription factor activity
I6K63_RS07450	COG1063	alcohol dehydrogenase
I6K63_RS07455	COG1879	ABC-type sugar transport system periplasmic component
I6K63_RS07460	COG1129	ABC transporter
I6K63_RS07465	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS07470	COG1070	Carbohydrate kinase
I6K63_RS07475	COG3623	hexulose-6-phosphate isomerase
I6K63_RS07485	COG0745	RESPONSE REGULATOR receiver
I6K63_RS07490	COG2205	protein histidine kinase activity
I6K63_RS07520	COG0415	Belongs to the DNA photolyase family
I6K63_RS07530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K63_RS07535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K63_RS07540	COG1984	allophanate hydrolase subunit 2
I6K63_RS07570	COG0372	Belongs to the citrate synthase family
I6K63_RS07580	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K63_RS07585	COG1053	succinate dehydrogenase
I6K63_RS07590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K63_RS07595	COG0567	Dehydrogenase, E1 component
I6K63_RS07600	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K63_RS07610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K63_RS07630	COG3246	L-lysine catabolic process to acetate
I6K63_RS07635	COG3622	Belongs to the hyi family
I6K63_RS07640	COG1349	DNA-binding transcription factor activity
I6K63_RS07645	COG0235	Class ii aldolase
I6K63_RS07650	COG3395	kinase activity
I6K63_RS07660	COG0583	DNA-binding transcription factor activity
I6K63_RS07670	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS07670	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS07680	COG1301	dicarboxylic acid transport
I6K63_RS07695	COG3799	methylaspartate ammonia-lyase activity
I6K63_RS07700	COG4865	methylaspartate mutase activity
I6K63_RS07710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K63_RS07715	COG1271	oxidase subunit
I6K63_RS07720	COG1294	oxidase, subunit
I6K63_RS07725	COG4890	Cyd operon protein YbgT
I6K63_RS07730	COG3790	cyd operon protein YbgE
I6K63_RS07735	COG0824	Thioesterase
I6K63_RS07740	COG0811	peptide transport
I6K63_RS07745	COG0848	biopolymer transport protein
I6K63_RS07750	COG3064	Membrane
I6K63_RS07760	COG2885	chlorophyll binding
I6K63_RS07765	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K63_RS07795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K63_RS07815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K63_RS07825	COG2017	converts alpha-aldose to the beta-anomer
I6K63_RS07835	COG1085	galactose-1-phosphate uridylyltransferase
I6K63_RS07840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K63_RS07845	COG1119	ATPase activity
I6K63_RS07850	COG3585	molybdate ion transport
I6K63_RS07850	COG2005	Transcriptional regulator
I6K63_RS07860	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K63_RS07865	COG4149	molybdate abc transporter
I6K63_RS07875	COG0561	phosphatase activity
I6K63_RS07890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K63_RS07910	COG2200	EAL domain
I6K63_RS07915	COG0789	Transcriptional regulator
I6K63_RS07930	COG4677	pectinesterase activity
I6K63_RS07975	COG1881	PFAM PEBP family protein
I6K63_RS07980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K63_RS07995	COG2226	methyltransferase
I6K63_RS08040	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K63_RS08050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K63_RS08055	COG0314	molybdopterin synthase activity
I6K63_RS08060	COG0670	Belongs to the BI1 family
I6K63_RS08065	COG0392	lysyltransferase activity
I6K63_RS08070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K63_RS08075	COG3568	Endonuclease Exonuclease Phosphatase
I6K63_RS08085	COG0842	Transport permease protein
I6K63_RS08090	COG0842	Transport permease protein
I6K63_RS08095	COG1131	(ABC) transporter
I6K63_RS08100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS08105	COG1309	transcriptional regulator
I6K63_RS08110	COG0583	DNA-binding transcription factor activity
I6K63_RS08115	COG2271	Major facilitator Superfamily
I6K63_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS08125	COG3959	Transketolase, thiamine diphosphate binding domain
I6K63_RS08130	COG3958	Transketolase
I6K63_RS08135	COG0513	Belongs to the DEAD box helicase family
I6K63_RS08150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K63_RS08160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K63_RS08165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K63_RS08175	COG0668	transmembrane transport
I6K63_RS08180	COG1126	abc transporter atp-binding protein
I6K63_RS08185	COG0765	amino acid transport
I6K63_RS08190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS08205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K63_RS08210	COG2194	sulfuric ester hydrolase activity
I6K63_RS08225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K63_RS08230	COG0667	Aldo Keto reductase
I6K63_RS08235	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS08240	COG2188	Transcriptional regulator
I6K63_RS08245	COG1376	ErfK ybiS ycfS ynhG family protein
I6K63_RS08255	COG0488	(ABC) transporter
I6K63_RS08265	COG2271	Major facilitator Superfamily
I6K63_RS08270	COG1609	Transcriptional regulator
I6K63_RS08280	COG0561	phosphatase activity
I6K63_RS08285	COG1882	Formate acetyltransferase
I6K63_RS08290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K63_RS08295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K63_RS08300	COG0303	'Molybdopterin
I6K63_RS08305	COG1446	asparaginase
I6K63_RS08315	COG0747	negative chemotaxis
I6K63_RS08340	COG2223	nitrite transmembrane transporter activity
I6K63_RS08350	COG2133	pyrroloquinoline quinone binding
I6K63_RS08355	COG0625	glutathione transferase activity
I6K63_RS08360	COG1686	Belongs to the peptidase S11 family
I6K63_RS08365	COG1349	DNA-binding transcription factor activity
I6K63_RS08370	COG0671	phosphoesterase, PA-phosphatase related
I6K63_RS08375	COG2814	Major facilitator Superfamily
I6K63_RS08380	COG0561	phosphatase activity
I6K63_RS08385	COG0738	Major facilitator superfamily
I6K63_RS08390	COG3226	Transcriptional regulator
I6K63_RS08445	COG0778	Nitroreductase
I6K63_RS08460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K63_RS08465	COG3842	ATPase activity
I6K63_RS08470	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K63_RS08475	COG1177	transmembrane transport
I6K63_RS08490	COG0745	RESPONSE REGULATOR receiver
I6K63_RS08495	COG5002	protein histidine kinase activity
I6K63_RS08500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS08505	COG4160	amino acid transport
I6K63_RS08510	COG4215	(ABC) transporter
I6K63_RS08515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS08520	COG1126	abc transporter atp-binding protein
I6K63_RS08530	COG0393	Putative heavy-metal-binding
I6K63_RS08535	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K63_RS08540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K63_RS08545	COG0702	epimerase
I6K63_RS08550	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K63_RS08555	COG0028	Belongs to the TPP enzyme family
I6K63_RS08565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K63_RS08575	COG2431	L-lysine efflux transmembrane transporter activity
I6K63_RS08580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K63_RS08585	COG3593	DNA synthesis involved in DNA repair
I6K63_RS08590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS08600	COG1278	Cold shock
I6K63_RS08610	COG0542	response to heat
I6K63_RS08620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6K63_RS08630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K63_RS08635	COG4988	ABC transporter
I6K63_RS08640	COG0492	ferredoxin-NADP+ reductase activity
I6K63_RS08650	COG1674	ftsk spoiiie
I6K63_RS08650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K63_RS08660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K63_RS08670	COG0243	molybdopterin cofactor binding
I6K63_RS08675	COG0437	4 iron, 4 sulfur cluster binding
I6K63_RS08680	COG3302	dmso reductase anchor subunit
I6K63_RS08690	COG0477	Major facilitator Superfamily
I6K63_RS08695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS08700	COG3958	Transketolase
I6K63_RS08705	COG3959	Transketolase, thiamine diphosphate binding domain
I6K63_RS08720	COG1737	Transcriptional regulator
I6K63_RS08725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K63_RS08730	COG1882	Formate acetyltransferase
I6K63_RS08735	COG2116	formate transmembrane transporter activity
I6K63_RS08740	COG1944	ATP diphosphatase activity
I6K63_RS08745	COG2323	membrane
I6K63_RS08760	COG0501	Belongs to the peptidase M48B family
I6K63_RS08770	COG0539	negative regulation of cytoplasmic translation
I6K63_RS08780	COG2333	competence protein COMEC
I6K63_RS08780	COG0658	competence protein
I6K63_RS08785	COG1132	(ABC) transporter
I6K63_RS08795	COG3214	Protein conserved in bacteria
I6K63_RS08810	COG3173	Aminoglycoside phosphotransferase
I6K63_RS08815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K63_RS08820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K63_RS08830	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K63_RS08840	COG2989	Protein conserved in bacteria
I6K63_RS08845	COG3108	Peptidase M15
I6K63_RS08850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K63_RS08855	COG1448	Aminotransferase
I6K63_RS08860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K63_RS08870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6K63_RS08875	COG0308	aminopeptidase N
I6K63_RS08885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K63_RS08890	COG0431	NADPH-dependent FMN reductase
I6K63_RS08905	COG3217	Mosc domain protein beta barrel domain protein
I6K63_RS08905	COG0633	Ferredoxin
I6K63_RS08915	COG0488	(ABC) transporter
I6K63_RS08920	COG2995	paraquat-inducible protein a
I6K63_RS08925	COG3008	intermembrane lipid transfer
I6K63_RS08925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K63_RS08930	COG3009	Protein conserved in bacteria
I6K63_RS08935	COG3130	regulation of translation
I6K63_RS08945	COG1067	ATP-dependent peptidase activity
I6K63_RS08965	COG3070	regulator of competence-specific genes
I6K63_RS08970	COG1289	transmembrane transporter activity
I6K63_RS08975	COG3304	Inner membrane component domain
I6K63_RS08980	COG0210	DNA helicase
I6K63_RS08990	COG1832	CoA-binding protein
I6K63_RS09050	COG2274	protein secretion by the type I secretion system
I6K63_RS09055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS09060	COG0438	transferase activity, transferring glycosyl groups
I6K63_RS09080	COG1881	PFAM PEBP family protein
I6K63_RS09085	COG2207	Transcriptional regulator
I6K63_RS09095	COG2920	part of a sulfur-relay system
I6K63_RS09100	COG0670	Belongs to the BI1 family
I6K63_RS09160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K63_RS09195	COG1396	sequence-specific DNA binding
I6K63_RS09215	COG1484	DNA-dependent DNA replication
I6K63_RS09285	COG1475	DNA binding
I6K63_RS09455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS09455	COG3711	transcriptional antiterminator
I6K63_RS09460	COG3711	transcriptional antiterminator
I6K63_RS09465	COG1609	Transcriptional regulator
I6K63_RS09470	COG1757	Na H antiporter
I6K63_RS09475	COG0436	Aminotransferase
I6K63_RS09485	COG1278	Cold shock
I6K63_RS09490	COG1278	Cold shock
I6K63_RS09495	COG1652	LysM domain
I6K63_RS09505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K63_RS09515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K63_RS09560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K63_RS09565	COG2233	PERMEase
I6K63_RS09575	COG2351	hydroxyisourate hydrolase activity
I6K63_RS09580	COG0402	S-adenosylhomocysteine deaminase activity
I6K63_RS09585	COG1953	Uracil, thiamine, allantoin
I6K63_RS09640	COG0765	amino acid transport
I6K63_RS09650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K63_RS09665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K63_RS09695	COG3706	GGDEF domain
I6K63_RS09700	COG2207	Transcriptional regulator
I6K63_RS09710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS09715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K63_RS09720	COG1882	Formate acetyltransferase
I6K63_RS09725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS09730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS09735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K63_RS09735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS09735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS09740	COG0473	3-isopropylmalate dehydrogenase activity
I6K63_RS09745	COG0583	DNA-binding transcription factor activity
I6K63_RS09750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K63_RS09755	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS09760	COG1396	sequence-specific DNA binding
I6K63_RS09760	COG1917	Cupin 2, conserved barrel domain protein
I6K63_RS09765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K63_RS09770	COG0174	glutamine synthetase
I6K63_RS09775	COG0531	amino acid
I6K63_RS09805	COG3729	General stress protein
I6K63_RS09810	COG2233	PERMEase
I6K63_RS09845	COG1309	transcriptional regulator
I6K63_RS09860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K63_RS09870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K63_RS09890	COG1702	phosphate starvation-inducible protein PhoH
I6K63_RS09910	COG1335	isochorismatase
I6K63_RS09920	COG0583	DNA-binding transcription factor activity
I6K63_RS09940	COG3381	protein complex oligomerization
I6K63_RS09980	COG5645	(Lipo)protein
I6K63_RS09995	COG1560	Kdo2-lipid A biosynthetic process
I6K63_RS10035	COG2999	glutathione oxidoreductase activity
I6K63_RS10045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K63_RS10055	COG0673	inositol 2-dehydrogenase activity
I6K63_RS10065	COG2814	Major facilitator Superfamily
I6K63_RS10070	COG0583	DNA-binding transcription factor activity
I6K63_RS10075	COG1530	ribonuclease E activity
I6K63_RS10095	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K63_RS10115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K63_RS10130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K63_RS10165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K63_RS10170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K63_RS10180	COG0470	DNA polymerase III
I6K63_RS10185	COG0084	hydrolase, TatD family'
I6K63_RS10195	COG4773	Receptor
I6K63_RS10200	COG0537	adenosine 5'-monophosphoramidase activity
I6K63_RS10205	COG5633	Lipoprotein
I6K63_RS10230	COG1252	NADH dehydrogenase
I6K63_RS10235	COG3134	Outer membrane lipoprotein
I6K63_RS10245	COG1309	transcriptional regulator
I6K63_RS10255	COG1376	ErfK ybiS ycfS ynhG family protein
I6K63_RS10255	COG1388	LysM domain
I6K63_RS10260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K63_RS10265	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K63_RS10270	COG1136	(ABC) transporter
I6K63_RS10275	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K63_RS10285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K63_RS10295	COG2390	Transcriptional regulator
I6K63_RS10310	COG3395	kinase activity
I6K63_RS10325	COG0698	ribose 5-phosphate isomerase
I6K63_RS10330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K63_RS10335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K63_RS10350	COG1177	transmembrane transport
I6K63_RS10370	COG2850	peptidyl-arginine hydroxylation
I6K63_RS10375	COG2205	protein histidine kinase activity
I6K63_RS10380	COG0745	RESPONSE REGULATOR receiver
I6K63_RS10390	COG2814	Major facilitator Superfamily
I6K63_RS10395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K63_RS10415	COG1187	pseudouridine synthase activity
I6K63_RS10420	COG0538	isocitrate dehydrogenase activity
I6K63_RS10430	COG3706	GGDEF domain
I6K63_RS10435	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K63_RS10450	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K63_RS10455	COG4772	TonB-dependent receptor
I6K63_RS10460	COG3712	iron ion homeostasis
I6K63_RS10465	COG1595	DNA-templated transcription, initiation
I6K63_RS10470	COG2226	methyltransferase
I6K63_RS10475	COG1560	Kdo2-lipid A biosynthetic process
I6K63_RS10485	COG3182	Iron-regulated membrane protein
I6K63_RS10505	COG2199	diguanylate cyclase activity
I6K63_RS10505	COG2203	Gaf domain
I6K63_RS10510	COG3042	response to heat
I6K63_RS10515	COG3189	MarR family transcriptional regulator
I6K63_RS10520	COG1683	Conserved Protein
I6K63_RS10525	COG0504	CTP synthase activity
I6K63_RS10530	COG2807	transmembrane transport
I6K63_RS10535	COG2207	Transcriptional regulator
I6K63_RS10545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K63_RS10550	COG2199	diguanylate cyclase activity
I6K63_RS10555	COG0859	PFAM glycosyl transferase family 9
I6K63_RS10565	COG2766	serine protein kinase
I6K63_RS10570	COG3713	MltA-interacting MipA family protein
I6K63_RS10575	COG0656	L-ascorbic acid biosynthetic process
I6K63_RS10595	COG3139	Protein of unknown function (DUF1315)
I6K63_RS10610	COG1063	alcohol dehydrogenase
I6K63_RS10615	COG2271	Major facilitator Superfamily
I6K63_RS10620	COG1063	alcohol dehydrogenase
I6K63_RS10625	COG0191	fructose-bisphosphate aldolase activity
I6K63_RS10630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS10635	COG0667	Aldo Keto reductase
I6K63_RS10640	COG1349	DNA-binding transcription factor activity
I6K63_RS10645	COG2814	Major facilitator Superfamily
I6K63_RS10650	COG1335	isochorismatase
I6K63_RS10655	COG0252	asparaginase activity
I6K63_RS10660	COG0616	signal peptide processing
I6K63_RS10665	COG0778	Nitroreductase
I6K63_RS10675	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K63_RS10680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K63_RS10685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K63_RS10690	COG0494	nUDIX hydrolase
I6K63_RS10695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K63_RS10705	COG2897	thiosulfate sulfurtransferase activity
I6K63_RS10710	COG4136	ATPase activity
I6K63_RS10715	COG4135	transport system, permease component
I6K63_RS10720	COG4134	Bacterial extracellular solute-binding protein
I6K63_RS10725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K63_RS10730	COG0398	Pfam SNARE associated Golgi protein
I6K63_RS10735	COG0398	Pfam SNARE associated Golgi protein
I6K63_RS10740	COG0708	Exodeoxyribonuclease III
I6K63_RS10760	COG3724	N-succinylarginine dihydrolase activity
I6K63_RS10770	COG3678	ATP-independent chaperone mediated protein folding
I6K63_RS10775	COG1704	LemA family
I6K63_RS10785	COG0322	excinuclease ABC activity
I6K63_RS10795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K63_RS10800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS10805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS10810	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K63_RS10815	COG2169	Transcriptional regulator
I6K63_RS10815	COG1917	Cupin 2, conserved barrel domain protein
I6K63_RS10820	COG1486	melibiose metabolic process
I6K63_RS10830	COG0753	catalase activity
I6K63_RS10840	COG1823	symporter activity
I6K63_RS10845	COG1988	membrane-bound metal-dependent
I6K63_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS10855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K63_RS10875	COG0038	chloride channel
I6K63_RS10890	COG3047	cAMP biosynthetic process
I6K63_RS10905	COG2207	Transcriptional regulator
I6K63_RS10905	COG3708	Transcriptional regulator
I6K63_RS10920	COG0135	phosphoribosylanthranilate isomerase activity
I6K63_RS10920	COG0134	indole-3-glycerol-phosphate synthase activity
I6K63_RS10925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K63_RS10925	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K63_RS10930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K63_RS10940	COG0009	L-threonylcarbamoyladenylate synthase
I6K63_RS10945	COG1187	pseudouridine synthase activity
I6K63_RS10950	COG2211	Major facilitator Superfamily
I6K63_RS10955	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K63_RS10960	COG2207	Transcriptional regulator
I6K63_RS10965	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K63_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS10975	COG0616	signal peptide processing
I6K63_RS11000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K63_RS11010	COG0671	phosphoesterase, PA-phosphatase related
I6K63_RS11015	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K63_RS11020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K63_RS11030	COG0023	Translation Initiation Factor
I6K63_RS11040	COG1349	DNA-binding transcription factor activity
I6K63_RS11055	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K63_RS11055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K63_RS11060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K63_RS11070	COG4172	Belongs to the ABC transporter superfamily
I6K63_RS11080	COG4171	peptide transport system, permease
I6K63_RS11085	COG4168	peptide transport system, permease
I6K63_RS11105	COG1473	amidohydrolase
I6K63_RS11115	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K63_RS11120	COG1842	Phage shock protein A
I6K63_RS11130	COG1983	PspC domain protein
I6K63_RS11140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K63_RS11145	COG3106	COG3106 Predicted ATPase
I6K63_RS11160	COG3180	Ammonia monooxygenase
I6K63_RS11165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K63_RS11170	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS11175	COG2866	Carboxypeptidase
I6K63_RS11180	COG4166	transmembrane transport
I6K63_RS11195	COG2885	chlorophyll binding
I6K63_RS11295	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K63_RS11300	COG2211	Major facilitator Superfamily
I6K63_RS11310	COG3272	Protein of unknown function (DUF1722)
I6K63_RS11320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K63_RS11335	COG0300	oxidoreductase activity
I6K63_RS11345	COG0789	Transcriptional regulator
I6K63_RS11375	COG0583	DNA-binding transcription factor activity
I6K63_RS11405	COG3477	response to acidic pH
I6K63_RS11425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K63_RS11435	COG0673	inositol 2-dehydrogenase activity
I6K63_RS11440	COG1349	DNA-binding transcription factor activity
I6K63_RS11445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K63_RS11455	COG3539	Fimbrial protein
I6K63_RS11460	COG3121	Chaperone
I6K63_RS11475	COG3539	Fimbrial protein
I6K63_RS11480	COG2197	response regulator
I6K63_RS11490	COG0513	Belongs to the DEAD box helicase family
I6K63_RS11505	COG0589	response to stress
I6K63_RS11515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K63_RS11520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K63_RS11520	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K63_RS11520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K63_RS11520	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K63_RS11600	COG3042	response to heat
I6K63_RS11605	COG3187	Heat shock protein
I6K63_RS11610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K63_RS11615	COG0586	Pfam SNARE associated Golgi protein
I6K63_RS11620	COG2911	Protein conserved in bacteria
I6K63_RS11630	COG3784	Protein of unknown function (DUF1318)
I6K63_RS11635	COG2207	Transcriptional regulator
I6K63_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS11645	COG1247	-acetyltransferase
I6K63_RS11650	COG3708	Transcriptional regulator
I6K63_RS11650	COG2207	Transcriptional regulator
I6K63_RS11655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS11680	COG4977	sequence-specific DNA binding
I6K63_RS11690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K63_RS11695	COG4977	sequence-specific DNA binding
I6K63_RS11705	COG1335	isochorismatase
I6K63_RS11710	COG2814	Major facilitator Superfamily
I6K63_RS11720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K63_RS11730	COG1335	isochorismatase
I6K63_RS11740	COG0406	alpha-ribazole phosphatase activity
I6K63_RS11745	COG2188	Transcriptional regulator
I6K63_RS11755	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K63_RS11760	COG3775	system Galactitol-specific IIC component
I6K63_RS11770	COG0191	fructose-bisphosphate aldolase activity
I6K63_RS11790	COG2030	dehydratase
I6K63_RS11790	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS11795	COG3396	Phenylacetate-CoA oxygenase
I6K63_RS11800	COG3460	Phenylacetate-CoA oxygenase
I6K63_RS11805	COG3396	Phenylacetate-CoA oxygenase
I6K63_RS11810	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K63_RS11815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K63_RS11820	COG1024	Enoyl-CoA hydratase
I6K63_RS11825	COG1024	Enoyl-CoA hydratase
I6K63_RS11830	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K63_RS11835	COG2050	protein possibly involved in aromatic compounds catabolism
I6K63_RS11840	COG0183	Belongs to the thiolase family
I6K63_RS11845	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K63_RS11850	COG3327	negative regulation of DNA-templated transcription, initiation
I6K63_RS11855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K63_RS11870	COG1643	Atp-dependent helicase
I6K63_RS11875	COG4122	O-methyltransferase activity
I6K63_RS11880	COG1538	Outer membrane efflux protein
I6K63_RS11900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K63_RS11905	COG0477	Major facilitator Superfamily
I6K63_RS11910	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K63_RS11915	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS11920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K63_RS11930	COG0583	DNA-binding transcription factor activity
I6K63_RS11935	COG3706	GGDEF domain
I6K63_RS11955	COG3038	cytochrome b561
I6K63_RS11985	COG0583	DNA-binding transcription factor activity
I6K63_RS11990	COG3485	protocatechuate 3,4-dioxygenase
I6K63_RS11995	COG3485	protocatechuate 3,4-dioxygenase
I6K63_RS12000	COG5383	Protein conserved in bacteria
I6K63_RS12005	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K63_RS12010	COG1335	isochorismatase
I6K63_RS12020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K63_RS12025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K63_RS12030	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K63_RS12035	COG0500	methyltransferase
I6K63_RS12040	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K63_RS12045	COG0747	negative chemotaxis
I6K63_RS12055	COG0697	spore germination
I6K63_RS12065	COG3135	benzoate transporter
I6K63_RS12070	COG1396	sequence-specific DNA binding
I6K63_RS12075	COG0826	peptidase U32
I6K63_RS12090	COG1294	oxidase, subunit
I6K63_RS12095	COG1271	oxidase subunit
I6K63_RS12100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K63_RS12105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K63_RS12110	COG3842	ATPase activity
I6K63_RS12115	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K63_RS12120	COG1177	transmembrane transport
I6K63_RS12125	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS12155	COG4677	pectinesterase activity
I6K63_RS12160	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS12165	COG0747	negative chemotaxis
I6K63_RS12175	COG3238	Protein conserved in bacteria
I6K63_RS12180	COG1247	-acetyltransferase
I6K63_RS12195	COG2130	NADP-dependent
I6K63_RS12205	COG3691	Protein conserved in bacteria
I6K63_RS12210	COG4772	TonB-dependent receptor
I6K63_RS12235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K63_RS12240	COG1473	amidohydrolase
I6K63_RS12245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K63_RS12250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS12265	COG1126	abc transporter atp-binding protein
I6K63_RS12275	COG2271	Major facilitator Superfamily
I6K63_RS12285	COG1609	Transcriptional regulator
I6K63_RS12290	COG0625	glutathione transferase activity
I6K63_RS12305	COG2211	Major facilitator Superfamily
I6K63_RS12315	COG4977	sequence-specific DNA binding
I6K63_RS12320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K63_RS12325	COG3842	ATPase activity
I6K63_RS12330	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K63_RS12335	COG1178	ABC-type Fe3 transport system permease component
I6K63_RS12340	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K63_RS12345	COG2181	nitrate reductase activity
I6K63_RS12350	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K63_RS12355	COG1140	nitrate reductase beta subunit
I6K63_RS12360	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K63_RS12365	COG2223	nitrite transmembrane transporter activity
I6K63_RS12380	COG1414	Transcriptional regulator
I6K63_RS12385	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS12390	COG4829	muconolactone delta-isomerase
I6K63_RS12405	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K63_RS12420	COG0697	spore germination
I6K63_RS12430	COG0437	4 iron, 4 sulfur cluster binding
I6K63_RS12435	COG2864	formate dehydrogenase
I6K63_RS12445	COG2814	Major facilitator Superfamily
I6K63_RS12455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K63_RS12465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K63_RS12480	COG1064	alcohol dehydrogenase
I6K63_RS12495	COG0488	(ABC) transporter
I6K63_RS12500	COG0745	RESPONSE REGULATOR receiver
I6K63_RS12520	COG0583	DNA-binding transcription factor activity
I6K63_RS12530	COG1764	response to oxidative stress
I6K63_RS12545	COG3781	membrane
I6K63_RS12550	COG0243	molybdopterin cofactor binding
I6K63_RS12555	COG1280	lysine exporter protein (LysE YggA)
I6K63_RS12565	COG0583	DNA-binding transcription factor activity
I6K63_RS12580	COG2271	Major facilitator Superfamily
I6K63_RS12640	COG0519	Catalyzes the synthesis of GMP from XMP
I6K63_RS12640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K63_RS12650	COG0300	oxidoreductase activity
I6K63_RS12655	COG0076	glutamate decarboxylase activity
I6K63_RS12660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K63_RS12665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K63_RS12670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K63_RS12675	COG1116	anion transmembrane transporter activity
I6K63_RS12680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K63_RS12685	COG0673	inositol 2-dehydrogenase activity
I6K63_RS12690	COG1082	Xylose isomerase domain protein TIM barrel
I6K63_RS12735	COG1649	PFAM Uncharacterised BCR, COG1649
I6K63_RS12740	COG2200	EAL domain
I6K63_RS12740	COG2771	luxR family
I6K63_RS12745	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K63_RS12760	COG0401	homolog of Blt101
I6K63_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS12780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K63_RS12800	COG2828	Protein conserved in bacteria
I6K63_RS12805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K63_RS12810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K63_RS12815	COG0583	DNA-binding transcription factor activity
I6K63_RS12820	COG3384	dioxygenase
I6K63_RS12840	COG1760	l-serine dehydratase
I6K63_RS12845	COG0814	amino acid
I6K63_RS12875	COG2814	Major facilitator Superfamily
I6K63_RS12880	COG1132	(ABC) transporter
I6K63_RS12895	COG2226	methyltransferase
I6K63_RS12895	COG3433	isochorismatase activity
I6K63_RS12895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K63_RS12915	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K63_RS12920	COG4771	TonB-dependent receptor
I6K63_RS12940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS12940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS12950	COG3716	PTS system mannose fructose sorbose family IID component
I6K63_RS12960	COG2271	Major facilitator Superfamily
I6K63_RS12970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K63_RS13010	COG3539	Fimbrial protein
I6K63_RS13020	COG3121	Chaperone
I6K63_RS13025	COG3539	Fimbrial protein
I6K63_RS13055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K63_RS13085	COG2188	Transcriptional regulator
I6K63_RS13090	COG4821	SIS domain
I6K63_RS13105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS13130	COG2841	Protein conserved in bacteria
I6K63_RS13155	COG0583	DNA-binding transcription factor activity
I6K63_RS13170	COG0412	Dienelactone hydrolase
I6K63_RS13185	COG0693	protein deglycase activity
I6K63_RS13195	COG1609	Transcriptional regulator
I6K63_RS13210	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS13240	COG3188	usher protein
I6K63_RS13265	COG1070	Carbohydrate kinase
I6K63_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS13275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K63_RS13280	COG3775	system Galactitol-specific IIC component
I6K63_RS13290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K63_RS13300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS13305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K63_RS13310	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6K63_RS13325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS13330	COG1446	asparaginase
I6K63_RS13335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6K63_RS13345	COG2207	Transcriptional regulator
I6K63_RS13350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K63_RS13370	COG0765	amino acid transport
I6K63_RS13375	COG0765	amino acid transport
I6K63_RS13380	COG1126	abc transporter atp-binding protein
I6K63_RS13395	COG4628	conserved protein (DUF2132)
I6K63_RS13415	COG2011	ABC-type metal ion transport system permease component
I6K63_RS13430	COG0477	Major facilitator Superfamily
I6K63_RS13455	COG3121	Chaperone
I6K63_RS13490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K63_RS13495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS13540	COG2199	diguanylate cyclase activity
I6K63_RS13555	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS13560	COG0583	DNA-binding transcription factor activity
I6K63_RS13575	COG1349	DNA-binding transcription factor activity
I6K63_RS13580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K63_RS13585	COG3395	kinase activity
I6K63_RS13590	COG1454	alcohol dehydrogenase
I6K63_RS13595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K63_RS13600	COG0861	Integral membrane protein TerC family
I6K63_RS13660	COG2814	Major facilitator Superfamily
I6K63_RS13695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K63_RS13730	COG2200	EAL domain
I6K63_RS13750	COG2223	nitrite transmembrane transporter activity
I6K63_RS13755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K63_RS13785	COG3122	Protein conserved in bacteria
I6K63_RS13805	COG2135	peptidase activity
I6K63_RS13820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K63_RS13860	COG0339	signal peptide processing
I6K63_RS13865	COG4221	oxidoreductase activity
I6K63_RS13870	COG1802	Transcriptional regulator
I6K63_RS13875	COG0589	response to stress
I6K63_RS13880	COG0246	Mannitol dehydrogenase
I6K63_RS13885	COG0477	Major facilitator Superfamily
I6K63_RS13890	COG1063	alcohol dehydrogenase
I6K63_RS13895	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS13910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K63_RS13930	COG0437	4 iron, 4 sulfur cluster binding
I6K63_RS13935	COG3302	dmso reductase anchor subunit
I6K63_RS13950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K63_RS13955	COG1940	carbohydrate kinase activity
I6K63_RS13960	COG0583	DNA-binding transcription factor activity
I6K63_RS13965	COG2814	Major facilitator Superfamily
I6K63_RS13970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K63_RS13990	COG3591	Belongs to the peptidase S1B family
I6K63_RS13995	COG3300	MHYT domain
I6K63_RS13995	COG5001	Diguanylate cyclase
I6K63_RS14015	COG0628	permease
I6K63_RS14045	COG0679	Auxin Efflux Carrier
I6K63_RS14055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K63_RS14070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6K63_RS14075	COG3290	protein histidine kinase activity
I6K63_RS14080	COG4565	transcriptional regulatory protein
I6K63_RS14100	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS14100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS14105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K63_RS14110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K63_RS14120	COG0183	Belongs to the thiolase family
I6K63_RS14125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K63_RS14135	COG1414	Transcriptional regulator
I6K63_RS14140	COG2840	Smr protein MutS2
I6K63_RS14145	COG0583	DNA-binding transcription factor activity
I6K63_RS14155	COG1473	amidohydrolase
I6K63_RS14160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K63_RS14165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K63_RS14170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K63_RS14175	COG0589	response to stress
I6K63_RS14185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K63_RS14190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K63_RS14205	COG0531	amino acid
I6K63_RS14215	COG3136	membrane protein required for alginate biosynthesis
I6K63_RS14225	COG0745	RESPONSE REGULATOR receiver
I6K63_RS14230	COG2205	protein histidine kinase activity
I6K63_RS14245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS14245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS14250	COG1482	cell wall glycoprotein biosynthetic process
I6K63_RS14255	COG5339	Protein conserved in bacteria
I6K63_RS14260	COG1609	Transcriptional regulator
I6K63_RS14265	COG1263	PTS System
I6K63_RS14265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS14270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K63_RS14280	COG2391	methyltransferase activity
I6K63_RS14285	COG0425	Belongs to the sulfur carrier protein TusA family
I6K63_RS14300	COG0673	inositol 2-dehydrogenase activity
I6K63_RS14310	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS14345	COG4659	FMN binding
I6K63_RS14355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K63_RS14365	COG0625	glutathione transferase activity
I6K63_RS14385	COG3895	Periplasmic Protein
I6K63_RS14400	COG3706	GGDEF domain
I6K63_RS14415	COG1566	PFAM secretion protein HlyD family protein
I6K63_RS14420	COG1289	transmembrane transporter activity
I6K63_RS14430	COG4989	oxidoreductase activity
I6K63_RS14435	COG3313	Fe-S protein
I6K63_RS14440	COG1309	transcriptional regulator
I6K63_RS14445	COG1902	pentaerythritol trinitrate reductase activity
I6K63_RS14450	COG0346	lactoylglutathione lyase activity
I6K63_RS14460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K63_RS14465	COG0791	NLP P60 protein
I6K63_RS14475	COG2814	Major facilitator Superfamily
I6K63_RS14490	COG0583	DNA-binding transcription factor activity
I6K63_RS14495	COG2814	Major facilitator Superfamily
I6K63_RS14500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K63_RS14505	COG0307	riboflavin synthase, alpha
I6K63_RS14530	COG3729	General stress protein
I6K63_RS14535	COG3685	Protein conserved in bacteria
I6K63_RS14540	COG3685	Protein conserved in bacteria
I6K63_RS14545	COG3546	catalase activity
I6K63_RS14550	COG1271	oxidase subunit
I6K63_RS14555	COG1294	oxidase, subunit
I6K63_RS14560	COG0366	Alpha amylase catalytic
I6K63_RS14570	COG1546	Belongs to the CinA family
I6K63_RS14575	COG2323	membrane
I6K63_RS14585	COG1609	Transcriptional regulator
I6K63_RS14590	COG0366	Alpha amylase catalytic
I6K63_RS14605	COG4529	Protein conserved in bacteria
I6K63_RS14615	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K63_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS14625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K63_RS14640	COG1349	DNA-binding transcription factor activity
I6K63_RS14645	COG0346	lactoylglutathione lyase activity
I6K63_RS14660	COG2011	ABC-type metal ion transport system permease component
I6K63_RS14690	COG0444	Belongs to the ABC transporter superfamily
I6K63_RS14695	COG4608	Belongs to the ABC transporter superfamily
I6K63_RS14700	COG4993	Dehydrogenase
I6K63_RS14730	COG1757	Na H antiporter
I6K63_RS14735	COG0626	cystathionine gamma-synthase activity
I6K63_RS14740	COG1278	Cold shock
I6K63_RS14765	COG3842	ATPase activity
I6K63_RS14785	COG1136	(ABC) transporter
I6K63_RS14785	COG0577	efflux transmembrane transporter activity
I6K63_RS14795	COG1136	(ABC) transporter
I6K63_RS14795	COG0577	efflux transmembrane transporter activity
I6K63_RS14810	COG0672	)-iron permease
I6K63_RS14815	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K63_RS14820	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K63_RS14825	COG3383	formate dehydrogenase (NAD+) activity
I6K63_RS14840	COG1126	abc transporter atp-binding protein
I6K63_RS14845	COG0765	amino acid transport
I6K63_RS14865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS14870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS14875	COG1120	ATPase activity
I6K63_RS14880	COG4774	siderophore transport
I6K63_RS14885	COG1116	anion transmembrane transporter activity
I6K63_RS14890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K63_RS14905	COG1960	acyl-CoA dehydrogenase activity
I6K63_RS14910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K63_RS14915	COG0583	DNA-binding transcription factor activity
I6K63_RS14940	COG2814	Major facilitator Superfamily
I6K63_RS14975	COG1414	Transcriptional regulator
I6K63_RS14980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K63_RS14985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS14990	COG1120	ATPase activity
I6K63_RS15000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K63_RS15005	COG2271	Major facilitator Superfamily
I6K63_RS15010	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K63_RS15010	COG1082	Xylose isomerase domain protein TIM barrel
I6K63_RS15035	COG1376	ErfK ybiS ycfS ynhG family protein
I6K63_RS15050	COG0719	Fe-S assembly protein
I6K63_RS15055	COG0396	ATPase activity
I6K63_RS15060	COG0719	Fe-S assembly protein
I6K63_RS15065	COG0316	Belongs to the HesB IscA family
I6K63_RS15080	COG2261	transglycosylase associated protein
I6K63_RS15085	COG2050	protein possibly involved in aromatic compounds catabolism
I6K63_RS15090	COG0247	lactate metabolic process
I6K63_RS15090	COG0277	FAD linked oxidase domain protein
I6K63_RS15095	COG0628	permease
I6K63_RS15105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K63_RS15105	COG0574	Belongs to the PEP-utilizing enzyme family
I6K63_RS15115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K63_RS15120	COG4256	Hemin uptake protein
I6K63_RS15130	COG0791	NLP P60 protein
I6K63_RS15140	COG0386	Belongs to the glutathione peroxidase family
I6K63_RS15160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K63_RS15160	COG0072	phenylalanine-tRNA ligase activity
I6K63_RS15180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6K63_RS15205	COG3137	Salt-induced outer membrane protein
I6K63_RS15210	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K63_RS15220	COG3001	Fructosamine kinase
I6K63_RS15225	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K63_RS15230	COG2350	Protein conserved in bacteria
I6K63_RS15235	COG1902	pentaerythritol trinitrate reductase activity
I6K63_RS15255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K63_RS15265	COG0444	Belongs to the ABC transporter superfamily
I6K63_RS15270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K63_RS15275	COG0601	transmembrane transport
I6K63_RS15285	COG2095	MarC family integral membrane protein
I6K63_RS15290	COG1454	alcohol dehydrogenase
I6K63_RS15290	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS15310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K63_RS15315	COG0745	RESPONSE REGULATOR receiver
I6K63_RS15320	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K63_RS15330	COG0788	formyltetrahydrofolate deformylase activity
I6K63_RS15350	COG2181	nitrate reductase activity
I6K63_RS15355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K63_RS15360	COG1140	nitrate reductase beta subunit
I6K63_RS15365	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K63_RS15370	COG2223	nitrite transmembrane transporter activity
I6K63_RS15375	COG3850	Histidine kinase
I6K63_RS15380	COG2197	response regulator
I6K63_RS15385	COG4932	domain protein
I6K63_RS15390	COG0243	molybdopterin cofactor binding
I6K63_RS15395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K63_RS15395	COG2146	nitrite reductase [NAD(P)H] activity
I6K63_RS15400	COG1116	anion transmembrane transporter activity
I6K63_RS15410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K63_RS15415	COG3707	response regulator
I6K63_RS15420	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K63_RS15430	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K63_RS15435	COG4572	Cation transport regulator
I6K63_RS15440	COG0387	Pfam Sodium calcium exchanger
I6K63_RS15460	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K63_RS15490	COG0659	secondary active sulfate transmembrane transporter activity
I6K63_RS15510	COG0012	GTP binding
I6K63_RS15515	COG3829	transcription factor binding
I6K63_RS15520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K63_RS15525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K63_RS15530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K63_RS15540	COG0549	Belongs to the carbamate kinase family
I6K63_RS15545	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K63_RS15545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K63_RS15550	COG0493	'glutamate synthase
I6K63_RS15550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS15555	COG0402	S-adenosylhomocysteine deaminase activity
I6K63_RS15560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS15565	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS15565	COG0493	'glutamate synthase
I6K63_RS15570	COG2233	PERMEase
I6K63_RS15580	COG2068	MobA-Related Protein
I6K63_RS15595	COG2814	Major facilitator Superfamily
I6K63_RS15600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS15600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS15620	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6K63_RS15625	COG0583	DNA-binding transcription factor activity
I6K63_RS15645	COG2814	Major facilitator Superfamily
I6K63_RS15670	COG2308	Evidence 4 Homologs of previously reported genes of
I6K63_RS15675	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K63_RS15685	COG2211	Major facilitator Superfamily
I6K63_RS15690	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K63_RS15700	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K63_RS15720	COG2719	SpoVR family
I6K63_RS15750	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K63_RS15765	COG2894	cell division
I6K63_RS15775	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K63_RS15785	COG3065	identical protein binding
I6K63_RS15790	COG1214	PFAM Peptidase M22, glycoprotease
I6K63_RS15795	COG1199	ATP-dependent helicase activity
I6K63_RS15800	COG0251	oxidation-reduction process
I6K63_RS15810	COG3842	ATPase activity
I6K63_RS15815	COG0395	ABC-type sugar transport system, permease component
I6K63_RS15820	COG1175	transmembrane transport
I6K63_RS15825	COG1653	transport
I6K63_RS15855	COG1760	l-serine dehydratase
I6K63_RS15860	COG2200	EAL domain
I6K63_RS15865	COG1253	flavin adenine dinucleotide binding
I6K63_RS15870	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS15870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS15875	COG3715	PTS system
I6K63_RS15880	COG3716	PTS system mannose fructose sorbose family IID component
I6K63_RS15895	COG2226	methyltransferase
I6K63_RS15900	COG0768	penicillin binding
I6K63_RS15930	COG1414	Transcriptional regulator
I6K63_RS15935	COG2814	Major facilitator Superfamily
I6K63_RS15955	COG1956	GAF domain-containing protein
I6K63_RS15960	COG2995	paraquat-inducible protein a
I6K63_RS15965	COG3008	intermembrane lipid transfer
I6K63_RS15990	COG2990	Protein conserved in bacteria
I6K63_RS16030	COG1276	copper resistance
I6K63_RS16035	COG2372	response to copper ion
I6K63_RS16045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K63_RS16050	COG1770	oligopeptidase
I6K63_RS16055	COG2979	Protein of unknown function (DUF533)
I6K63_RS16060	COG3141	response to X-ray
I6K63_RS16070	COG0800	Aldolase
I6K63_RS16075	COG0129	dihydroxy-acid dehydratase activity
I6K63_RS16080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K63_RS16085	COG1737	Transcriptional regulator
I6K63_RS16095	COG1560	Kdo2-lipid A biosynthetic process
I6K63_RS16100	COG0739	heme binding
I6K63_RS16105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K63_RS16115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K63_RS16140	COG0217	transcriptional regulatory protein
I6K63_RS16145	COG0494	nUDIX hydrolase
I6K63_RS16155	COG1335	isochorismatase
I6K63_RS16160	COG1801	Protein of unknown function DUF72
I6K63_RS16165	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K63_RS16185	COG3102	Protein conserved in bacteria
I6K63_RS16195	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K63_RS16225	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS16235	COG1879	ABC-type sugar transport system periplasmic component
I6K63_RS16245	COG1528	Iron-storage protein
I6K63_RS16265	COG0477	Major facilitator Superfamily
I6K63_RS16275	COG1528	Iron-storage protein
I6K63_RS16285	COG0814	amino acid
I6K63_RS16290	COG3318	Belongs to the UPF0149 family
I6K63_RS16290	COG3012	SEC-C Motif Domain Protein
I6K63_RS16295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K63_RS16325	COG2197	response regulator
I6K63_RS16335	COG2197	response regulator
I6K63_RS16340	COG1126	abc transporter atp-binding protein
I6K63_RS16345	COG0765	amino acid transport
I6K63_RS16355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS16360	COG0366	Alpha amylase catalytic
I6K63_RS16390	COG5475	Uncharacterized small protein (DUF2158)
I6K63_RS16395	COG2354	Protein conserved in bacteria
I6K63_RS16400	COG0697	spore germination
I6K63_RS16405	COG3727	T/G mismatch-specific endonuclease activity
I6K63_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS16425	COG2271	Major facilitator Superfamily
I6K63_RS16430	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS16440	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS16450	COG2186	Transcriptional regulator
I6K63_RS16455	COG0129	dihydroxy-acid dehydratase activity
I6K63_RS16465	COG2084	Dehydrogenase
I6K63_RS16475	COG2271	Major facilitator Superfamily
I6K63_RS16480	COG2721	sulfolactate sulfo-lyase activity
I6K63_RS16485	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K63_RS16490	COG1418	mRNA catabolic process
I6K63_RS16500	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K63_RS16530	COG2819	hydrolase of the alpha beta superfamily
I6K63_RS16540	COG0589	response to stress
I6K63_RS16550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K63_RS16580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K63_RS16590	COG0534	Mate efflux family protein
I6K63_RS16615	COG2814	Major facilitator Superfamily
I6K63_RS16630	COG1376	ErfK ybiS ycfS ynhG family protein
I6K63_RS16670	COG3539	Fimbrial protein
I6K63_RS16675	COG3121	Chaperone
I6K63_RS16680	COG3188	usher protein
I6K63_RS16685	COG3539	Fimbrial protein
I6K63_RS16690	COG3539	Fimbrial protein
I6K63_RS16695	COG3539	Fimbrial protein
I6K63_RS16710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS16710	COG1263	PTS System
I6K63_RS16725	COG3615	Tellurite resistance protein tehB
I6K63_RS16730	COG5001	Diguanylate cyclase
I6K63_RS16730	COG3300	MHYT domain
I6K63_RS16740	COG0477	Major facilitator Superfamily
I6K63_RS16745	COG0095	Lipoate-protein ligase
I6K63_RS16750	COG0583	DNA-binding transcription factor activity
I6K63_RS16755	COG1942	4-Oxalocrotonate Tautomerase
I6K63_RS16765	COG1082	Xylose isomerase domain protein TIM barrel
I6K63_RS16770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS16770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS16775	COG0673	inositol 2-dehydrogenase activity
I6K63_RS16780	COG2814	Major facilitator Superfamily
I6K63_RS16790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K63_RS16810	COG1289	transmembrane transporter activity
I6K63_RS16830	COG2925	Exonuclease
I6K63_RS16835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K63_RS16840	COG0640	Transcriptional regulator
I6K63_RS16845	COG0531	amino acid
I6K63_RS16860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K63_RS16875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K63_RS16890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K63_RS16915	COG0438	transferase activity, transferring glycosyl groups
I6K63_RS16975	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6K63_RS16985	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K63_RS16995	COG2244	polysaccharide biosynthetic process
I6K63_RS17015	COG0463	Glycosyl transferase, family 2
I6K63_RS17035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K63_RS17070	COG1253	flavin adenine dinucleotide binding
I6K63_RS17075	COG2982	Protein involved in outer membrane biogenesis
I6K63_RS17090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K63_RS17095	COG0443	Heat shock 70 kDa protein
I6K63_RS17100	COG0372	Belongs to the citrate synthase family
I6K63_RS17105	COG5002	protein histidine kinase activity
I6K63_RS17125	COG1301	dicarboxylic acid transport
I6K63_RS17135	COG1522	sequence-specific DNA binding
I6K63_RS17145	COG4215	(ABC) transporter
I6K63_RS17150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS17180	COG2205	protein histidine kinase activity
I6K63_RS17185	COG0745	RESPONSE REGULATOR receiver
I6K63_RS17205	COG0826	peptidase U32
I6K63_RS17225	COG4608	Belongs to the ABC transporter superfamily
I6K63_RS17230	COG0444	Belongs to the ABC transporter superfamily
I6K63_RS17235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K63_RS17240	COG0601	transmembrane transport
I6K63_RS17245	COG0747	negative chemotaxis
I6K63_RS17250	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS17255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K63_RS17265	COG1070	Carbohydrate kinase
I6K63_RS17290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K63_RS17295	COG1830	Aldolase
I6K63_RS17300	COG0351	phosphomethylpyrimidine kinase
I6K63_RS17310	COG0583	DNA-binding transcription factor activity
I6K63_RS17320	COG2252	PERMEase
I6K63_RS17330	COG0583	DNA-binding transcription factor activity
I6K63_RS17335	COG5455	response to cobalt ion
I6K63_RS17355	COG3831	ATPase activity
I6K63_RS17360	COG3831	ATPase activity
I6K63_RS17365	COG3831	ATPase activity
I6K63_RS17370	COG0714	Associated with various cellular activities
I6K63_RS17375	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K63_RS17385	COG4715	Zinc finger, swim domain protein
I6K63_RS17390	COG4808	Protein conserved in bacteria
I6K63_RS17395	COG4807	Protein conserved in bacteria
I6K63_RS17405	COG3275	phosphorelay sensor kinase activity
I6K63_RS17410	COG0789	Transcriptional regulator
I6K63_RS17420	COG1174	glycine betaine transport
I6K63_RS17425	COG1125	glycine betaine transport
I6K63_RS17430	COG1174	glycine betaine transport
I6K63_RS17435	COG1732	Glycine betaine
I6K63_RS17440	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K63_RS17445	COG0277	FAD linked oxidase domain protein
I6K63_RS17455	COG1686	Belongs to the peptidase S11 family
I6K63_RS17465	COG0586	Pfam SNARE associated Golgi protein
I6K63_RS17470	COG1538	Outer membrane efflux protein
I6K63_RS17475	COG2226	methyltransferase
I6K63_RS17480	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS17490	COG3711	transcriptional antiterminator
I6K63_RS17495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K63_RS17500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K63_RS17505	COG0625	glutathione transferase activity
I6K63_RS17520	COG2271	Major facilitator Superfamily
I6K63_RS17525	COG0583	DNA-binding transcription factor activity
I6K63_RS17535	COG1346	cytolysis
I6K63_RS17545	COG2949	membrane
I6K63_RS17555	COG1129	ABC transporter
I6K63_RS17570	COG2311	Membrane
I6K63_RS17585	COG4771	TonB-dependent receptor
I6K63_RS17590	COG0833	amino acid
I6K63_RS17605	COG0583	DNA-binding transcription factor activity
I6K63_RS17610	COG2855	membrane
I6K63_RS17620	COG1522	sequence-specific DNA binding
I6K63_RS17620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS17625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K63_RS17630	COG2313	pseudouridylate synthase activity
I6K63_RS17635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS17640	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K63_RS17640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS17640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS17645	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K63_RS17650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS17650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS17665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6K63_RS17670	COG0246	Mannitol dehydrogenase
I6K63_RS17675	COG0523	cobalamin synthesis protein
I6K63_RS17680	COG0671	phosphoesterase, PA-phosphatase related
I6K63_RS17685	COG0791	NLP P60 protein
I6K63_RS17690	COG2200	EAL domain
I6K63_RS17695	COG4166	transmembrane transport
I6K63_RS17700	COG4174	ABC transporter (Permease)
I6K63_RS17705	COG4239	(ABC) transporter, permease
I6K63_RS17710	COG4172	Belongs to the ABC transporter superfamily
I6K63_RS17720	COG2814	Major facilitator Superfamily
I6K63_RS17725	COG1187	pseudouridine synthase activity
I6K63_RS17730	COG1061	Type III restriction enzyme res subunit
I6K63_RS17740	COG0494	nUDIX hydrolase
I6K63_RS17745	COG1349	DNA-binding transcription factor activity
I6K63_RS17805	COG0628	permease
I6K63_RS17820	COG0659	secondary active sulfate transmembrane transporter activity
I6K63_RS17825	COG2239	Acts as a magnesium transporter
I6K63_RS17830	COG4615	Cyclic peptide transporter
I6K63_RS17835	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K63_RS17840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K63_RS17840	COG2169	Transcriptional regulator
I6K63_RS17855	COG0642	Histidine kinase
I6K63_RS17855	COG2198	Histidine kinase
I6K63_RS17865	COG0784	Response regulator, receiver
I6K63_RS17865	COG2205	protein histidine kinase activity
I6K63_RS17890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K63_RS17895	COG0584	glycerophosphoryl diester phosphodiesterase
I6K63_RS17900	COG2271	Major facilitator Superfamily
I6K63_RS17905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K63_RS17915	COG0247	lactate metabolic process
I6K63_RS17925	COG2271	Major facilitator Superfamily
I6K63_RS17935	COG1414	Transcriptional regulator
I6K63_RS17990	COG3647	Membrane
I6K63_RS17995	COG0318	PFAM AMP-dependent synthetase and ligase
I6K63_RS18020	COG1169	isochorismate synthase
I6K63_RS18025	COG2153	protein acetylation
I6K63_RS18035	COG0582	viral genome integration into host DNA
I6K63_RS18065	COG0582	viral genome integration into host DNA
I6K63_RS18075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K63_RS18080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K63_RS18085	COG0713	ATP synthesis coupled electron transport
I6K63_RS18090	COG0839	Belongs to the complex I subunit 6 family
I6K63_RS18140	COG0583	DNA-binding transcription factor activity
I6K63_RS18145	COG0436	Aminotransferase
I6K63_RS18155	COG0471	metal ion transport
I6K63_RS18155	COG0490	domain, Protein
I6K63_RS18160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K63_RS18185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6K63_RS18190	COG3959	Transketolase, thiamine diphosphate binding domain
I6K63_RS18205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS18210	COG1609	Transcriptional regulator
I6K63_RS18220	COG0622	Phosphoesterase
I6K63_RS18225	COG0625	glutathione transferase activity
I6K63_RS18230	COG0625	glutathione transferase activity
I6K63_RS18235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K63_RS18240	COG1090	epimerase
I6K63_RS18260	COG4598	ABC transporter
I6K63_RS18265	COG4160	amino acid transport
I6K63_RS18285	COG0163	prenyltransferase activity
I6K63_RS18290	COG1609	Transcriptional regulator
I6K63_RS18295	COG1940	carbohydrate kinase activity
I6K63_RS18300	COG2211	Major facilitator Superfamily
I6K63_RS18310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K63_RS18315	COG1286	toxin biosynthetic process
I6K63_RS18320	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K63_RS18325	COG0285	dihydrofolate synthase activity
I6K63_RS18335	COG0586	Pfam SNARE associated Golgi protein
I6K63_RS18345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K63_RS18365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K63_RS18380	COG3101	peptidyl-lysine hydroxylation
I6K63_RS18385	COG0730	response to heat
I6K63_RS18410	COG2062	phosphohistidine phosphatase, SixA
I6K63_RS18425	COG3691	Protein conserved in bacteria
I6K63_RS18440	COG2116	formate transmembrane transporter activity
I6K63_RS18455	COG0583	DNA-binding transcription factor activity
I6K63_RS18460	COG2807	transmembrane transport
I6K63_RS18470	COG0436	Aminotransferase
I6K63_RS18475	COG3275	phosphorelay sensor kinase activity
I6K63_RS18480	COG3279	Response regulator of the LytR AlgR family
I6K63_RS18495	COG3961	Belongs to the TPP enzyme family
I6K63_RS18500	COG0667	Aldo Keto reductase
I6K63_RS18515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K63_RS18520	COG2199	diguanylate cyclase activity
I6K63_RS18520	COG2200	EAL domain
I6K63_RS18535	COG3415	Transposase
I6K63_RS18540	COG3415	Transposase
I6K63_RS18570	COG0583	DNA-binding transcription factor activity
I6K63_RS18575	COG2211	Major facilitator Superfamily
I6K63_RS18580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6K63_RS18585	COG0583	DNA-binding transcription factor activity
I6K63_RS18590	COG0385	Bile acid
I6K63_RS18595	COG3530	Putative quorum-sensing-regulated virulence factor
I6K63_RS18615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K63_RS18655	COG4319	ketosteroid isomerase
I6K63_RS18665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K63_RS18670	COG4208	sulfate ABC transporter
I6K63_RS18675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K63_RS18680	COG4150	thiosulfate binding
I6K63_RS18685	COG2837	iron assimilation
I6K63_RS18705	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K63_RS18715	COG2207	Transcriptional regulator
I6K63_RS18785	COG4766	ethanolamine catabolic process
I6K63_RS18795	COG4810	utilization protein
I6K63_RS18805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K63_RS18810	COG5342	invasion associated locus B
I6K63_RS18820	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS18820	COG0493	'glutamate synthase
I6K63_RS18825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K63_RS18835	COG1393	Belongs to the ArsC family
I6K63_RS18850	COG0400	carboxylic ester hydrolase activity
I6K63_RS18860	COG2321	neutral zinc metallopeptidase
I6K63_RS18870	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K63_RS18880	COG2716	regulation of RNA biosynthetic process
I6K63_RS18885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K63_RS18890	COG0628	permease
I6K63_RS18895	COG4783	chaperone-mediated protein folding
I6K63_RS18900	COG1393	Belongs to the ArsC family
I6K63_RS18910	COG2233	PERMEase
I6K63_RS18920	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS18935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K63_RS18950	COG2200	EAL domain
I6K63_RS18970	COG0583	DNA-binding transcription factor activity
I6K63_RS18975	COG0583	DNA-binding transcription factor activity
I6K63_RS18985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K63_RS18985	COG0519	Catalyzes the synthesis of GMP from XMP
I6K63_RS18990	COG0517	IMP dehydrogenase activity
I6K63_RS18990	COG0516	GMP reductase activity
I6K63_RS18995	COG1570	exodeoxyribonuclease VII activity
I6K63_RS19010	COG1645	bacterial-type flagellum-dependent swarming motility
I6K63_RS19020	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K63_RS19035	COG2976	Protein conserved in bacteria
I6K63_RS19065	COG4953	penicillin-binding protein 1C
I6K63_RS19070	COG2373	Large extracellular alpha-helical protein
I6K63_RS19080	COG1473	amidohydrolase
I6K63_RS19085	COG2897	thiosulfate sulfurtransferase activity
I6K63_RS19100	COG2975	iron-sulfur cluster assembly
I6K63_RS19105	COG0633	Ferredoxin
I6K63_RS19125	COG0822	iron-sulfur transferase activity
I6K63_RS19150	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K63_RS19155	COG3683	transport system, periplasmic component
I6K63_RS19160	COG3711	transcriptional antiterminator
I6K63_RS19165	COG2814	Major facilitator Superfamily
I6K63_RS19170	COG2017	converts alpha-aldose to the beta-anomer
I6K63_RS19175	COG2814	Major facilitator Superfamily
I6K63_RS19175	COG0477	Major facilitator Superfamily
I6K63_RS19180	COG0457	Tetratricopeptide repeat
I6K63_RS19185	COG1940	carbohydrate kinase activity
I6K63_RS19190	COG2259	Doxx family
I6K63_RS19200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K63_RS19200	COG1017	nitric oxide dioxygenase activity
I6K63_RS19205	COG1609	Transcriptional regulator
I6K63_RS19225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K63_RS19230	COG0371	Dehydrogenase
I6K63_RS19235	COG0347	Belongs to the P(II) protein family
I6K63_RS19240	COG2204	response regulator
I6K63_RS19245	COG3170	Tfp pilus assembly protein FimV
I6K63_RS19250	COG2205	protein histidine kinase activity
I6K63_RS19255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K63_RS19255	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K63_RS19270	COG0560	Phosphoserine phosphatase
I6K63_RS19275	COG1737	Transcriptional regulator
I6K63_RS19280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K63_RS19285	COG2223	nitrite transmembrane transporter activity
I6K63_RS19290	COG0583	DNA-binding transcription factor activity
I6K63_RS19295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS19305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K63_RS19325	COG0681	Belongs to the peptidase S26 family
I6K63_RS19335	COG3086	response to oxidative stress
I6K63_RS19340	COG3026	antisigma factor binding
I6K63_RS19345	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K63_RS19360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K63_RS19370	COG0513	Belongs to the DEAD box helicase family
I6K63_RS19385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K63_RS19390	COG3118	belongs to the thioredoxin family
I6K63_RS19395	COG3148	PFAM DTW domain containing protein
I6K63_RS19405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K63_RS19410	COG5544	Lipoprotein
I6K63_RS19415	COG0477	Major facilitator Superfamily
I6K63_RS19445	COG0542	response to heat
I6K63_RS19460	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K63_RS19465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K63_RS19475	COG0077	Prephenate dehydratase
I6K63_RS19475	COG1605	Chorismate mutase
I6K63_RS19485	COG1605	Chorismate mutase
I6K63_RS19485	COG0287	Prephenate dehydrogenase
I6K63_RS19490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K63_RS19500	COG2199	diguanylate cyclase activity
I6K63_RS19505	COG2885	chlorophyll binding
I6K63_RS19540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K63_RS19545	COG4137	Cytochrome C assembly protein
I6K63_RS19550	COG4536	flavin adenine dinucleotide binding
I6K63_RS19565	COG0497	DNA recombination
I6K63_RS19580	COG2867	negative regulation of translational initiation
I6K63_RS19795	COG3179	chitinase
I6K63_RS19835	COG0484	heat shock protein binding
I6K63_RS19840	COG1403	HNH endonuclease
I6K63_RS19845	COG3561	AntA/AntB antirepressor
I6K63_RS19865	COG4725	Belongs to the MT-A70-like family
I6K63_RS19875	COG1802	Transcriptional regulator
I6K63_RS19875	COG4626	Terminase
I6K63_RS19890	COG4197	protein conserved in bacteria, prophage-related
I6K63_RS19895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K63_RS19910	COG5532	Uncharacterized conserved protein (DUF2303)
I6K63_RS19915	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6K63_RS19950	COG0582	viral genome integration into host DNA
I6K63_RS19960	COG0582	viral genome integration into host DNA
I6K63_RS20000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6K63_RS20005	COG3586	endonuclease activity
I6K63_RS20015	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K63_RS20030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS20030	COG2190	(PTS) system
I6K63_RS20030	COG1263	PTS System
I6K63_RS20065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS20070	COG1126	abc transporter atp-binding protein
I6K63_RS20075	COG0235	Class ii aldolase
I6K63_RS20085	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS20090	COG2814	Major facilitator Superfamily
I6K63_RS20120	COG3188	usher protein
I6K63_RS20125	COG3121	Chaperone
I6K63_RS20140	COG3284	Transcriptional regulator
I6K63_RS20145	COG0640	Transcriptional regulator
I6K63_RS20150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K63_RS20175	COG4575	ribosome binding
I6K63_RS20185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K63_RS20190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K63_RS20200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K63_RS20215	COG4176	ABC-type proline glycine betaine transport system permease component
I6K63_RS20225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K63_RS20235	COG1846	Transcriptional regulator
I6K63_RS20240	COG1566	PFAM secretion protein HlyD family protein
I6K63_RS20245	COG2814	Major facilitator Superfamily
I6K63_RS20250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K63_RS20270	COG1238	metal cluster binding
I6K63_RS20275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K63_RS20280	COG2823	Periplasmic or secreted lipoprotein
I6K63_RS20305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K63_RS20325	COG1546	Belongs to the CinA family
I6K63_RS20335	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K63_RS20340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K63_RS20350	COG2951	lytic endotransglycosylase activity
I6K63_RS20355	COG3730	PTS system glucitol sorbitol-specific
I6K63_RS20360	COG3732	PTS system glucitol sorbitol-specific
I6K63_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS20375	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS20380	COG1349	DNA-binding transcription factor activity
I6K63_RS20405	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K63_RS20410	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K63_RS20415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS20420	COG1609	Transcriptional regulator
I6K63_RS20425	COG1263	PTS System
I6K63_RS20425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS20430	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS20435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K63_RS20445	COG3260	NADH ubiquinone oxidoreductase 20
I6K63_RS20450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K63_RS20455	COG3261	NADH dehydrogenase
I6K63_RS20455	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K63_RS20460	COG0650	Formate hydrogenlyase subunit 4
I6K63_RS20465	COG0651	ATP synthesis coupled electron transport
I6K63_RS20470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS20485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K63_RS20490	COG0298	carbon dioxide binding
I6K63_RS20495	COG0409	Hydrogenase expression formation protein
I6K63_RS20500	COG0309	Hydrogenase expression formation protein (HypE)
I6K63_RS20510	COG2755	lipolytic protein G-D-S-L family
I6K63_RS20510	COG0657	acetylesterase activity
I6K63_RS20515	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS20525	COG4580	involved in the transport of maltose and maltodextrins
I6K63_RS20530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS20535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS20540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS20545	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K63_RS20550	COG1940	carbohydrate kinase activity
I6K63_RS20555	COG1609	Transcriptional regulator
I6K63_RS20565	COG1121	(ABC) transporter
I6K63_RS20570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K63_RS20575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K63_RS20595	COG3720	iron ion transport
I6K63_RS20600	COG4558	Periplasmic binding protein
I6K63_RS20605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K63_RS20610	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6K63_RS20615	COG1454	alcohol dehydrogenase
I6K63_RS20655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K63_RS20660	COG1538	Outer membrane efflux protein
I6K63_RS20670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS20675	COG1132	(ABC) transporter
I6K63_RS20700	COG3539	Fimbrial protein
I6K63_RS20705	COG3539	Fimbrial protein
I6K63_RS20715	COG3121	Chaperone
I6K63_RS20720	COG3188	usher protein
I6K63_RS20730	COG3539	Fimbrial protein
I6K63_RS20750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K63_RS20770	COG0477	Major facilitator Superfamily
I6K63_RS20780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K63_RS20785	COG4942	peptidase
I6K63_RS20785	COG1388	LysM domain
I6K63_RS20845	COG2234	aminopeptidase activity
I6K63_RS20895	COG0720	synthase
I6K63_RS20900	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS20905	COG0602	queuosine metabolic process
I6K63_RS20925	COG3956	TIGRFAM MazG family protein
I6K63_RS20935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K63_RS20945	COG4999	Histidine kinase
I6K63_RS20945	COG2205	protein histidine kinase activity
I6K63_RS20945	COG3850	Histidine kinase
I6K63_RS20945	COG3437	response regulator, receiver
I6K63_RS20950	COG1929	Belongs to the glycerate kinase type-1 family
I6K63_RS20955	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS20960	COG4948	Mandelate Racemase Muconate Lactonizing
I6K63_RS20965	COG2271	Major facilitator Superfamily
I6K63_RS20970	COG0716	FMN binding
I6K63_RS20975	COG0564	pseudouridine synthase activity
I6K63_RS20980	COG3098	single-species biofilm formation
I6K63_RS20995	COG1611	Belongs to the LOG family
I6K63_RS21000	COG0814	amino acid
I6K63_RS21005	COG1760	l-serine dehydratase
I6K63_RS21010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K63_RS21030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K63_RS21035	COG3829	transcription factor binding
I6K63_RS21045	COG0235	Class ii aldolase
I6K63_RS21050	COG0738	Major facilitator superfamily
I6K63_RS21070	COG1349	DNA-binding transcription factor activity
I6K63_RS21080	COG2363	Small membrane protein
I6K63_RS21085	COG0583	DNA-binding transcription factor activity
I6K63_RS21095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K63_RS21100	COG2166	iron-sulfur cluster assembly
I6K63_RS21105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K63_RS21110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K63_RS21275	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K63_RS21290	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K63_RS21305	COG1012	belongs to the aldehyde dehydrogenase family
I6K63_RS21305	COG1454	alcohol dehydrogenase
I6K63_RS21310	COG4656	Part of a membrane complex involved in electron transport
I6K63_RS21340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K63_RS21345	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K63_RS21350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K63_RS21350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K63_RS21355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K63_RS21360	COG1074	ATP-dependent DNA helicase activity
I6K63_RS21365	COG1025	Belongs to the peptidase M16 family
I6K63_RS21370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K63_RS21375	COG4967	type IV pilus modification protein PilV
I6K63_RS21385	COG4795	General secretion pathway protein
I6K63_RS21390	COG2165	general secretion pathway protein
I6K63_RS21425	COG0861	Integral membrane protein TerC family
I6K63_RS21435	COG0667	Aldo Keto reductase
I6K63_RS21450	COG1609	Transcriptional regulator
I6K63_RS21460	COG2186	Transcriptional regulator
I6K63_RS21465	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS21470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS21475	COG1609	Transcriptional regulator
I6K63_RS21485	COG0583	DNA-binding transcription factor activity
I6K63_RS21490	COG1794	racemase activity, acting on amino acids and derivatives
I6K63_RS21500	COG1175	transmembrane transport
I6K63_RS21505	COG0395	ABC-type sugar transport system, permease component
I6K63_RS21510	COG3842	ATPase activity
I6K63_RS21520	COG0823	Involved in the tonB-independent uptake of proteins
I6K63_RS21545	COG2814	Major facilitator Superfamily
I6K63_RS21550	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS21555	COG0823	Involved in the tonB-independent uptake of proteins
I6K63_RS21565	COG0183	Belongs to the thiolase family
I6K63_RS21580	COG0814	amino acid
I6K63_RS21585	COG0667	Aldo Keto reductase
I6K63_RS21630	COG0640	Transcriptional regulator
I6K63_RS21645	COG0697	spore germination
I6K63_RS21650	COG1846	Transcriptional regulator
I6K63_RS21655	COG1522	sequence-specific DNA binding
I6K63_RS21665	COG0582	viral genome integration into host DNA
I6K63_RS21670	COG4974	Belongs to the 'phage' integrase family
I6K63_RS21680	COG3539	Fimbrial protein
I6K63_RS21685	COG3121	Chaperone
I6K63_RS21690	COG3188	usher protein
I6K63_RS21695	COG3539	Fimbrial protein
I6K63_RS21700	COG3539	Fimbrial protein
I6K63_RS21705	COG3539	Fimbrial protein
I6K63_RS21715	COG2388	GCN5-related N-acetyl-transferase
I6K63_RS21720	COG3592	Divergent 4Fe-4S mono-cluster
I6K63_RS21735	COG1289	transmembrane transporter activity
I6K63_RS21740	COG1538	Outer membrane efflux protein
I6K63_RS21760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K63_RS21760	COG2885	chlorophyll binding
I6K63_RS21810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K63_RS21815	COG1349	DNA-binding transcription factor activity
I6K63_RS21835	COG1349	DNA-binding transcription factor activity
I6K63_RS21840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K63_RS21845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS21850	COG0738	Major facilitator superfamily
I6K63_RS21895	COG1929	Belongs to the glycerate kinase type-1 family
I6K63_RS21900	COG3835	regulator
I6K63_RS21905	COG2223	nitrite transmembrane transporter activity
I6K63_RS21915	COG0529	Catalyzes the synthesis of activated sulfate
I6K63_RS21915	COG2046	Belongs to the sulfate adenylyltransferase family
I6K63_RS21930	COG3121	Chaperone
I6K63_RS21940	COG3188	usher protein
I6K63_RS21980	COG3121	Chaperone
I6K63_RS21985	COG3539	Fimbrial protein
I6K63_RS22000	COG2200	EAL domain
I6K63_RS22040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS22040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS22040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K63_RS22045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS22050	COG2207	Transcriptional regulator
I6K63_RS22055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS22065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K63_RS22070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K63_RS22075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K63_RS22075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS22075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS22080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS22085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS22085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS22110	COG4942	peptidase
I6K63_RS22115	COG0583	DNA-binding transcription factor activity
I6K63_RS22120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K63_RS22130	COG1811	Na channel or pump
I6K63_RS22150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K63_RS22165	COG0716	FMN binding
I6K63_RS22175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K63_RS22185	COG1272	protein, Hemolysin III
I6K63_RS22195	COG1737	Transcriptional regulator
I6K63_RS22200	COG2723	6-phospho-beta-galactosidase activity
I6K63_RS22205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K63_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS22230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K63_RS22235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K63_RS22240	COG0006	proline dipeptidase activity
I6K63_RS22260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K63_RS22265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K63_RS22280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K63_RS22280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K63_RS22285	COG1703	isobutyryl-CoA mutase activity
I6K63_RS22290	COG1024	Enoyl-CoA hydratase
I6K63_RS22295	COG0427	acetyl-CoA hydrolase
I6K63_RS22300	COG0583	DNA-binding transcription factor activity
I6K63_RS22305	COG2968	Membrane
I6K63_RS22310	COG1279	arginine transmembrane transporter activity
I6K63_RS22315	COG0668	transmembrane transport
I6K63_RS22320	COG0191	fructose-bisphosphate aldolase activity
I6K63_RS22350	COG1122	ATPase activity
I6K63_RS22355	COG1122	ATPase activity
I6K63_RS22360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K63_RS22365	COG0501	Belongs to the peptidase M48B family
I6K63_RS22380	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K63_RS22385	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS22400	COG2814	Major facilitator Superfamily
I6K63_RS22415	COG1414	Transcriptional regulator
I6K63_RS22420	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS22435	COG2146	nitrite reductase [NAD(P)H] activity
I6K63_RS22450	COG1166	arginine decarboxylase activity
I6K63_RS22470	COG2814	Major facilitator Superfamily
I6K63_RS22480	COG2356	endonuclease I
I6K63_RS22485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K63_RS22490	COG0189	ligase activity
I6K63_RS22505	COG2197	response regulator
I6K63_RS22510	COG2805	Type II/IV secretion system protein
I6K63_RS22515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K63_RS22520	COG0762	integral membrane protein
I6K63_RS22535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K63_RS22540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K63_RS22545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K63_RS22565	COG3171	Protein conserved in bacteria
I6K63_RS22575	COG1194	a g-specific adenine glycosylase
I6K63_RS22590	COG2211	Major facilitator Superfamily
I6K63_RS22595	COG1982	Orn Lys Arg decarboxylase major
I6K63_RS22600	COG1811	Na channel or pump
I6K63_RS22635	COG3710	Transcriptional regulator
I6K63_RS22660	COG3188	usher protein
I6K63_RS22670	COG0471	metal ion transport
I6K63_RS22685	COG0626	cystathionine gamma-synthase activity
I6K63_RS22690	COG0583	DNA-binding transcription factor activity
I6K63_RS22710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K63_RS22715	COG0754	glutathionylspermidine amidase activity
I6K63_RS22725	COG0625	glutathione transferase activity
I6K63_RS22750	COG2211	Major facilitator Superfamily
I6K63_RS22755	COG0848	biopolymer transport protein
I6K63_RS22765	COG0626	cystathionine gamma-synthase activity
I6K63_RS22770	COG0586	Pfam SNARE associated Golgi protein
I6K63_RS22775	COG2207	Transcriptional regulator
I6K63_RS22780	COG1979	alcohol dehydrogenase
I6K63_RS22795	COG1032	radical SAM domain protein
I6K63_RS22800	COG2132	Multicopper oxidase
I6K63_RS22805	COG0204	Acyl-transferase
I6K63_RS22815	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K63_RS22825	COG0642	Histidine kinase
I6K63_RS22830	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K63_RS22835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K63_RS22840	COG0187	DNA topoisomerase II activity
I6K63_RS22845	COG3150	esterase
I6K63_RS22850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K63_RS22855	COG3151	Protein conserved in bacteria
I6K63_RS22860	COG0494	nUDIX hydrolase
I6K63_RS22875	COG0754	glutathionylspermidine amidase activity
I6K63_RS22880	COG3384	dioxygenase
I6K63_RS22895	COG2960	long-chain fatty acid transporting porin activity
I6K63_RS22915	COG3025	triphosphatase activity
I6K63_RS22920	COG4991	sh3 domain protein
I6K63_RS22935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K63_RS22990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K63_RS23050	COG2376	Dihydroxyacetone kinase
I6K63_RS23055	COG1461	Dihydroxyacetone kinase
I6K63_RS23070	COG2375	cellular response to nickel ion
I6K63_RS23075	COG1695	Transcriptional regulator
I6K63_RS23085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K63_RS23090	COG1609	Transcriptional regulator
I6K63_RS23095	COG3250	beta-galactosidase activity
I6K63_RS23100	COG2731	YhcH YjgK YiaL family protein
I6K63_RS23105	COG0531	amino acid
I6K63_RS23110	COG0531	amino acid
I6K63_RS23120	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K63_RS23120	COG3408	Glycogen debranching enzyme
I6K63_RS23145	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS23165	COG1902	pentaerythritol trinitrate reductase activity
I6K63_RS23165	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K63_RS23180	COG2211	Major facilitator Superfamily
I6K63_RS23190	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K63_RS23195	COG1451	nucleotide metabolic process
I6K63_RS23200	COG0673	inositol 2-dehydrogenase activity
I6K63_RS23220	COG2721	sulfolactate sulfo-lyase activity
I6K63_RS23230	COG2271	Major facilitator Superfamily
I6K63_RS23235	COG2186	Transcriptional regulator
I6K63_RS23240	COG0586	Pfam SNARE associated Golgi protein
I6K63_RS23250	COG1422	Protein of unknown function (DUF1090)
I6K63_RS23255	COG4575	ribosome binding
I6K63_RS23260	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K63_RS23270	COG2259	Doxx family
I6K63_RS23275	COG0435	Glutathione S-transferase
I6K63_RS23280	COG3152	Membrane
I6K63_RS23285	COG0583	DNA-binding transcription factor activity
I6K63_RS23290	COG1741	Belongs to the pirin family
I6K63_RS23315	COG1929	Belongs to the glycerate kinase type-1 family
I6K63_RS23320	COG2084	Dehydrogenase
I6K63_RS23330	COG2271	Major facilitator Superfamily
I6K63_RS23335	COG2721	sulfolactate sulfo-lyase activity
I6K63_RS23340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS23345	COG1349	DNA-binding transcription factor activity
I6K63_RS23360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS23360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS23360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K63_RS23365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS23365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS23370	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
I6K63_RS23375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS23380	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K63_RS23385	COG3775	system Galactitol-specific IIC component
I6K63_RS23390	COG1063	alcohol dehydrogenase
I6K63_RS23400	COG3539	Fimbrial protein
I6K63_RS23405	COG3121	Chaperone
I6K63_RS23410	COG3188	usher protein
I6K63_RS23415	COG3539	Fimbrial protein
I6K63_RS23420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K63_RS23440	COG2823	Periplasmic or secreted lipoprotein
I6K63_RS23445	COG0701	Predicted permease
I6K63_RS23450	COG0702	epimerase
I6K63_RS23455	COG0693	protein deglycase activity
I6K63_RS23465	COG2827	Endonuclease containing a URI domain
I6K63_RS23470	COG3153	acetyltransferase
I6K63_RS23475	COG3154	lipid carrier protein
I6K63_RS23480	COG0826	peptidase U32
I6K63_RS23485	COG0826	peptidase U32
I6K63_RS23490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K63_RS23495	COG0814	amino acid
I6K63_RS23500	COG0513	Belongs to the DEAD box helicase family
I6K63_RS23535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6K63_RS23540	COG0195	Participates in both transcription termination and antitermination
I6K63_RS23565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K63_RS23575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K63_RS23580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K63_RS23590	COG1534	Rna-binding protein
I6K63_RS23595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K63_RS23600	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K63_RS23610	COG0697	spore germination
I6K63_RS23625	COG0142	geranyltranstransferase activity
I6K63_RS23630	COG3423	Transcriptional regulator
I6K63_RS23640	COG5007	Belongs to the BolA IbaG family
I6K63_RS23645	COG3113	response to antibiotic
I6K63_RS23650	COG2854	intermembrane phospholipid transfer
I6K63_RS23655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K63_RS23660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K63_RS23665	COG1127	ABC transporter
I6K63_RS23670	COG0530	calcium, potassium:sodium antiporter activity
I6K63_RS23680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K63_RS23685	COG3117	lipopolysaccharide transmembrane transporter activity
I6K63_RS23690	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K63_RS23695	COG1137	ATPase activity
I6K63_RS23700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K63_RS23705	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K63_RS23710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS23715	COG1660	Displays ATPase and GTPase activities
I6K63_RS23720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K63_RS23725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K63_RS23730	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K63_RS23735	COG5002	protein histidine kinase activity
I6K63_RS23735	COG0784	Response regulator, receiver
I6K63_RS23735	COG2198	Histidine kinase
I6K63_RS23740	COG1312	Catalyzes the dehydration of D-mannonate
I6K63_RS23745	COG1242	4 iron, 4 sulfur cluster binding
I6K63_RS23750	COG0067	glutamate synthase
I6K63_RS23750	COG0070	glutamate synthase
I6K63_RS23750	COG0069	glutamate synthase activity
I6K63_RS23755	COG0493	'glutamate synthase
I6K63_RS23760	COG3539	Fimbrial protein
I6K63_RS23770	COG3188	usher protein
I6K63_RS23775	COG3121	Chaperone
I6K63_RS23780	COG3539	Fimbrial protein
I6K63_RS23785	COG2969	positive regulation of protein catabolic process
I6K63_RS23790	COG0625	glutathione transferase activity
I6K63_RS23805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K63_RS23810	COG3105	Protein conserved in bacteria
I6K63_RS23815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K63_RS23820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K63_RS23835	COG5016	pyruvate
I6K63_RS23835	COG0511	ligase activity, forming carbon-carbon bonds
I6K63_RS23845	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS23850	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K63_RS23855	COG0471	metal ion transport
I6K63_RS23865	COG1802	Transcriptional regulator
I6K63_RS23890	COG2732	(Barnase) inhibitor
I6K63_RS23895	COG1289	transmembrane transporter activity
I6K63_RS23910	COG0583	DNA-binding transcription factor activity
I6K63_RS23915	COG1349	DNA-binding transcription factor activity
I6K63_RS23920	COG0312	modulator of DNA gyrase
I6K63_RS23925	COG3164	Protein of unknown function
I6K63_RS23930	COG1530	ribonuclease E activity
I6K63_RS23940	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K63_RS23945	COG1792	Involved in formation and maintenance of cell shape
I6K63_RS23950	COG1077	Cell shape determining protein MreB Mrl
I6K63_RS23955	COG2200	EAL domain
I6K63_RS23955	COG2199	diguanylate cyclase activity
I6K63_RS23960	COG0604	alcohol dehydrogenase
I6K63_RS23975	COG0511	ligase activity, forming carbon-carbon bonds
I6K63_RS23980	COG0439	Biotin carboxylase
I6K63_RS23985	COG3924	membrane
I6K63_RS23990	COG4145	pantothenate transmembrane transporter activity
I6K63_RS24015	COG1309	transcriptional regulator
I6K63_RS24020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS24025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K63_RS24065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K63_RS24085	COG0551	DNA topoisomerase type I activity
I6K63_RS24095	COG0758	DNA mediated transformation
I6K63_RS24125	COG3036	rescue of stalled ribosome
I6K63_RS24130	COG0789	Transcriptional regulator
I6K63_RS24140	COG0203	ribosomal protein L17
I6K63_RS24145	COG0202	RNA polymerase activity
I6K63_RS24155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6K63_RS24170	COG0201	protein transport
I6K63_RS24185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6K63_RS24235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K63_RS24250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K63_RS24265	COG0088	Forms part of the polypeptide exit tunnel
I6K63_RS24275	COG0051	transcription antitermination factor activity, RNA binding
I6K63_RS24330	COG2964	Protein conserved in bacteria
I6K63_RS24335	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K63_RS24345	COG1047	Peptidyl-prolyl cis-trans
I6K63_RS24350	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K63_RS24365	COG0488	(ABC) transporter
I6K63_RS24370	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K63_RS24380	COG3954	Phosphoribulokinase
I6K63_RS24385	COG1765	OsmC-like protein
I6K63_RS24395	COG1289	transmembrane transporter activity
I6K63_RS24400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K63_RS24425	COG0738	Major facilitator superfamily
I6K63_RS24430	COG0402	S-adenosylhomocysteine deaminase activity
I6K63_RS24435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K63_RS24440	COG2146	nitrite reductase [NAD(P)H] activity
I6K63_RS24470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K63_RS24475	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K63_RS24480	COG3266	domain, Protein
I6K63_RS24495	COG4796	Type ii and iii secretion system protein
I6K63_RS24520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K63_RS24525	COG0494	nUDIX hydrolase
I6K63_RS24535	COG1011	Hydrolase
I6K63_RS24540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K63_RS24555	COG1640	4-alpha-glucanotransferase
I6K63_RS24560	COG0058	SHG alpha-glucan phosphorylase activity
I6K63_RS24575	COG1690	Belongs to the RtcB family
I6K63_RS24580	COG4650	regulator
I6K63_RS24585	COG1349	DNA-binding transcription factor activity
I6K63_RS24600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K63_RS24605	COG0058	SHG alpha-glucan phosphorylase activity
I6K63_RS24630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K63_RS24635	COG2610	gluconate transmembrane transporter activity
I6K63_RS24640	COG3265	gluconokinase activity
I6K63_RS24645	COG1609	Transcriptional regulator
I6K63_RS24650	COG1741	Belongs to the pirin family
I6K63_RS24655	COG0673	inositol 2-dehydrogenase activity
I6K63_RS24665	COG1247	-acetyltransferase
I6K63_RS24670	COG0405	Gamma-glutamyltransferase
I6K63_RS24680	COG0584	glycerophosphoryl diester phosphodiesterase
I6K63_RS24705	COG1414	Transcriptional regulator
I6K63_RS24710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K63_RS24715	COG2271	Major facilitator Superfamily
I6K63_RS24720	COG2721	sulfolactate sulfo-lyase activity
I6K63_RS24745	COG0683	leucine binding
I6K63_RS24755	COG0683	leucine binding
I6K63_RS24770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K63_RS24785	COG2177	Part of the ABC transporter FtsEX involved in
I6K63_RS24790	COG2884	Cell division ATP-binding protein ftsE
I6K63_RS24795	COG0552	protein localization to endoplasmic reticulum
I6K63_RS24800	COG0742	ribosomal rna small subunit methyltransferase
I6K63_RS24805	COG3776	membrane
I6K63_RS24815	COG3714	YhhN family
I6K63_RS24830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K63_RS24840	COG0477	Major facilitator Superfamily
I6K63_RS24845	COG0628	permease
I6K63_RS24885	COG3479	Phenolic acid decarboxylase
I6K63_RS24895	COG0747	negative chemotaxis
I6K63_RS24900	COG0601	transmembrane transport
I6K63_RS24905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K63_RS24910	COG0444	Belongs to the ABC transporter superfamily
I6K63_RS24925	COG2239	Acts as a magnesium transporter
I6K63_RS24935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K63_RS24940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K63_RS24945	COG0471	metal ion transport
I6K63_RS24950	COG3964	amidohydrolase
I6K63_RS24955	COG2204	response regulator
I6K63_RS24960	COG2081	HI0933 family
I6K63_RS24965	COG0306	phosphate transporter
I6K63_RS24975	COG0589	response to stress
I6K63_RS24995	COG2610	gluconate transmembrane transporter activity
I6K63_RS25030	COG1918	ferrous iron import across plasma membrane
I6K63_RS25040	COG2183	response to ionizing radiation
I6K63_RS25045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K63_RS25060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K63_RS25065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K63_RS25075	COG1454	alcohol dehydrogenase
I6K63_RS25085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K63_RS25095	COG2197	response regulator
I6K63_RS25100	COG1028	Short-chain dehydrogenase reductase Sdr
I6K63_RS25105	COG0583	DNA-binding transcription factor activity
I6K63_RS25110	COG1295	ribonuclease BN
I6K63_RS25115	COG0477	Major facilitator Superfamily
I6K63_RS25120	COG2982	Protein involved in outer membrane biogenesis
I6K63_RS25130	COG0612	Peptidase, M16
I6K63_RS25140	COG2199	diguanylate cyclase activity
I6K63_RS25140	COG2200	EAL domain
I6K63_RS25145	COG0457	Tetratricopeptide repeat
I6K63_RS25145	COG3118	belongs to the thioredoxin family
I6K63_RS25155	COG1215	transferase activity, transferring glycosyl groups
I6K63_RS25185	COG2194	sulfuric ester hydrolase activity
I6K63_RS25215	COG0457	Tetratricopeptide repeat
I6K63_RS25230	COG0489	protein tyrosine kinase activity
I6K63_RS25240	COG4608	Belongs to the ABC transporter superfamily
I6K63_RS25245	COG0444	Belongs to the ABC transporter superfamily
I6K63_RS25250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K63_RS25255	COG0601	transmembrane transport
I6K63_RS25260	COG0747	negative chemotaxis
I6K63_RS25275	COG2223	nitrite transmembrane transporter activity
I6K63_RS25280	COG5571	outer membrane autotransporter
I6K63_RS25285	COG2818	Glycosylase
I6K63_RS25290	COG0456	acetyltransferase
I6K63_RS25295	COG0243	molybdopterin cofactor binding
I6K63_RS25300	COG2885	chlorophyll binding
I6K63_RS25305	COG1609	Transcriptional regulator
I6K63_RS25315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS25335	COG2814	Major facilitator Superfamily
I6K63_RS25340	COG2944	sequence-specific DNA binding
I6K63_RS25345	COG1278	Cold shock
I6K63_RS25375	COG3274	enterobacterial common antigen metabolic process
I6K63_RS25380	COG4682	membrane
I6K63_RS25385	COG1070	Carbohydrate kinase
I6K63_RS25390	COG2115	Belongs to the xylose isomerase family
I6K63_RS25395	COG4213	ABC transporter substrate-binding protein
I6K63_RS25405	COG4214	carbohydrate transport
I6K63_RS25410	COG1609	Transcriptional regulator
I6K63_RS25410	COG2207	Transcriptional regulator
I6K63_RS25415	COG2992	FlgJ-related protein
I6K63_RS25420	COG0366	Alpha amylase catalytic
I6K63_RS25425	COG3977	Valine--pyruvate aminotransferase
I6K63_RS25430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K63_RS25445	COG3276	selenocysteine insertion sequence binding
I6K63_RS25455	COG0625	glutathione transferase activity
I6K63_RS25460	COG1566	PFAM secretion protein HlyD family protein
I6K63_RS25480	COG3722	fumarate hydratase activity
I6K63_RS25500	COG2186	Transcriptional regulator
I6K63_RS25510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K63_RS25530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K63_RS25535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K63_RS25545	COG4942	peptidase
I6K63_RS25550	COG2861	carbohydrate metabolic process
I6K63_RS25555	COG0463	Glycosyl transferase, family 2
I6K63_RS25565	COG0156	8-amino-7-oxononanoate synthase activity
I6K63_RS25575	COG0859	PFAM glycosyl transferase family 9
I6K63_RS25580	COG0859	PFAM glycosyl transferase family 9
I6K63_RS25605	COG0859	PFAM glycosyl transferase family 9
I6K63_RS25615	COG0438	transferase activity, transferring glycosyl groups
I6K63_RS25620	COG1216	Glycosyl transferase, family 2
I6K63_RS25625	COG1519	Transferase
I6K63_RS25645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6K63_RS25650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6K63_RS25660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K63_RS25680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6K63_RS25690	COG1561	YicC-like family, N-terminal region
I6K63_RS25700	COG2860	membrane
I6K63_RS25720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K63_RS25725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K63_RS25730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K63_RS25735	COG1494	fructose-1,6-bisphosphatase
I6K63_RS25745	COG3152	Membrane
I6K63_RS25765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K63_RS25775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS25780	COG2211	Major facilitator Superfamily
I6K63_RS25795	COG3074	FtsZ-dependent cytokinesis
I6K63_RS25810	COG0786	glutamate:sodium symporter activity
I6K63_RS25815	COG2233	PERMEase
I6K63_RS25820	COG2982	Protein involved in outer membrane biogenesis
I6K63_RS25825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS25825	COG1263	PTS System
I6K63_RS25830	COG1486	melibiose metabolic process
I6K63_RS25840	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K63_RS25845	COG2211	Major facilitator Superfamily
I6K63_RS25860	COG3311	Transcriptional regulator
I6K63_RS25880	COG1064	alcohol dehydrogenase
I6K63_RS25890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K63_RS25905	COG1464	Belongs to the NlpA lipoprotein family
I6K63_RS25920	COG0583	DNA-binding transcription factor activity
I6K63_RS25930	COG1309	transcriptional regulator
I6K63_RS25940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS25945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K63_RS25955	COG2814	Major facilitator Superfamily
I6K63_RS25965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K63_RS25965	COG1263	PTS System
I6K63_RS25970	COG0697	spore germination
I6K63_RS25975	COG5464	transposase or invertase
I6K63_RS25985	COG1609	Transcriptional regulator
I6K63_RS25995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS25995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K63_RS26000	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K63_RS26005	COG4580	involved in the transport of maltose and maltodextrins
I6K63_RS26030	COG2188	Transcriptional regulator
I6K63_RS26070	COG2271	Major facilitator Superfamily
I6K63_RS26080	COG2197	response regulator
I6K63_RS26085	COG0440	acetolactate synthase activity
I6K63_RS26090	COG0028	Belongs to the TPP enzyme family
I6K63_RS26115	COG2814	Major facilitator Superfamily
I6K63_RS26120	COG0583	DNA-binding transcription factor activity
I6K63_RS26125	COG2610	gluconate transmembrane transporter activity
I6K63_RS26135	COG0641	radical SAM
I6K63_RS26145	COG2149	membrane
I6K63_RS26150	COG3119	arylsulfatase activity
I6K63_RS26155	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K63_RS26160	COG2207	Transcriptional regulator
I6K63_RS26175	COG2188	Transcriptional regulator
I6K63_RS26195	COG5645	(Lipo)protein
I6K63_RS26200	COG0823	Involved in the tonB-independent uptake of proteins
I6K63_RS26205	COG2271	Major facilitator Superfamily
I6K63_RS26215	COG0800	Aldolase
I6K63_RS26220	COG3734	2-keto-3-deoxy-galactonokinase
I6K63_RS26225	COG2186	Transcriptional regulator
I6K63_RS26230	COG0561	phosphatase activity
I6K63_RS26240	COG0583	DNA-binding transcription factor activity
I6K63_RS26245	COG0187	DNA topoisomerase II activity
I6K63_RS26255	COG0592	DNA-directed DNA polymerase activity
I6K63_RS26265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6K63_RS26275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K63_RS26295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K63_RS26300	COG1737	Transcriptional regulator
I6K63_RS26320	COG2731	YhcH YjgK YiaL family protein
I6K63_RS26335	COG2091	lysine biosynthetic process via aminoadipic acid
I6K63_RS26340	COG0431	NADPH-dependent FMN reductase
I6K63_RS26345	COG2252	PERMEase
I6K63_RS26350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K63_RS26355	COG0363	glucosamine-6-phosphate deaminase activity
I6K63_RS26360	COG2382	esterase
I6K63_RS26370	COG0704	Plays a role in the regulation of phosphate uptake
I6K63_RS26375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K63_RS26380	COG0581	inorganic phosphate transmembrane transporter activity
I6K63_RS26385	COG0573	inorganic phosphate transmembrane transporter activity
I6K63_RS26390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K63_RS26450	COG3312	ion transport
I6K63_RS26465	COG0716	FMN binding
I6K63_RS26470	COG1522	sequence-specific DNA binding
I6K63_RS26500	COG1129	ABC transporter
I6K63_RS26505	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS26515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K63_RS26520	COG1609	Transcriptional regulator
I6K63_RS26525	COG0477	Major facilitator Superfamily
I6K63_RS26530	COG2186	Transcriptional regulator
I6K63_RS26550	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K63_RS26555	COG0746	molybdenum cofactor guanylyltransferase activity
I6K63_RS26560	COG3084	Protein conserved in bacteria
I6K63_RS26565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K63_RS26575	COG0204	Acyl-transferase
I6K63_RS26595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K63_RS26610	COG3852	Histidine kinase
I6K63_RS26625	COG1011	Hydrolase
I6K63_RS26635	COG1490	D-aminoacyl-tRNA deacylase activity
I6K63_RS26640	COG0456	acetyltransferase
I6K63_RS26645	COG0657	acetylesterase activity
I6K63_RS26655	COG2864	formate dehydrogenase
I6K63_RS26660	COG0437	4 iron, 4 sulfur cluster binding
I6K63_RS26685	COG3716	PTS system mannose fructose sorbose family IID component
I6K63_RS26690	COG3715	PTS system
I6K63_RS26700	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K63_RS26720	COG0205	6-phosphofructokinase activity
I6K63_RS26765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K63_RS26785	COG2211	Major facilitator Superfamily
I6K63_RS26790	COG0110	maltose O-acetyltransferase activity
I6K63_RS26800	COG1609	Transcriptional regulator
I6K63_RS26805	COG2211	Major facilitator Superfamily
I6K63_RS26820	COG1454	alcohol dehydrogenase
I6K63_RS26830	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K63_RS26835	COG1129	ABC transporter
I6K63_RS26875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K63_RS26880	COG2258	MOSC domain
I6K63_RS26885	COG2205	protein histidine kinase activity
I6K63_RS26890	COG0745	RESPONSE REGULATOR receiver
I6K63_RS26895	COG3678	ATP-independent chaperone mediated protein folding
I6K63_RS26915	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K63_RS26930	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K63_RS26935	COG1609	Transcriptional regulator
I6K63_RS26940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K63_RS26955	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K63_RS26965	COG0626	cystathionine gamma-synthase activity
I6K63_RS26970	COG0527	aspartate kinase activity
I6K63_RS26970	COG0460	homoserine dehydrogenase
I6K63_RS26990	COG0583	DNA-binding transcription factor activity
I6K63_RS27000	COG0697	spore germination
I6K63_RS27005	COG1349	DNA-binding transcription factor activity
I6K63_RS27010	COG0371	Dehydrogenase
I6K63_RS27020	COG2207	Transcriptional regulator
I6K63_RS27030	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K63_RS27045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K63_RS27060	COG0583	DNA-binding transcription factor activity
I6K63_RS27135	COG3085	chromosome segregation
I6K63_RS27155	COG3978	acetolactate synthase activity
I6K63_RS27250	COG0745	RESPONSE REGULATOR receiver
I6K63_RS27255	COG2198	Histidine kinase
I6K63_RS27255	COG0784	Response regulator, receiver
I6K63_RS27255	COG5002	protein histidine kinase activity
I6K63_RS27260	COG0683	leucine binding
I6K63_RS27285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K63_RS27315	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K63_RS27320	COG0542	response to heat
I6K63_RS27335	COG0501	Belongs to the peptidase M48B family
I6K63_RS27350	COG2801	Transposase and inactivated derivatives
I6K63_RS27415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K63_RS27445	COG0431	NADPH-dependent FMN reductase
I6K63_RS27460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K63_RS27480	COG2205	protein histidine kinase activity
I6K63_RS27485	COG0745	RESPONSE REGULATOR receiver
I6K63_RS27490	COG1276	copper resistance
I6K63_RS27495	COG2372	response to copper ion
I6K63_RS27500	COG3667	copper resistance
I6K63_RS27505	COG2132	Multicopper oxidase
I6K63_RS27515	COG0739	heme binding
I6K63_RS27545	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K63_RS27590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K63_RS27600	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K63_RS27615	COG1716	ATPase activity
I6K63_RS27615	COG5001	Diguanylate cyclase
I6K63_RS27620	COG2199	diguanylate cyclase activity
I6K63_RS27620	COG2203	Gaf domain
I6K63_RS27680	COG3344	reverse transcriptase
I6K63_RS28200	COG1660	Displays ATPase and GTPase activities
I6K63_RS28235	COG4644	lycopene metabolic process
I6K63_RS28255	COG0697	spore germination