locus-tag	class	description
HV180_RS00010	COG0592	DNA-directed DNA polymerase activity
HV180_RS00020	COG0187	DNA topoisomerase II activity
HV180_RS00025	COG0583	DNA-binding transcription factor activity
HV180_RS00035	COG0561	phosphatase activity
HV180_RS00040	COG2186	Transcriptional regulator
HV180_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HV180_RS00050	COG0800	Aldolase
HV180_RS00060	COG2271	Major facilitator Superfamily
HV180_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HV180_RS00070	COG5645	(Lipo)protein
HV180_RS00090	COG2188	Transcriptional regulator
HV180_RS00105	COG2207	Transcriptional regulator
HV180_RS00110	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV180_RS00115	COG3119	arylsulfatase activity
HV180_RS00120	COG2149	membrane
HV180_RS00130	COG0641	radical SAM
HV180_RS00140	COG2610	gluconate transmembrane transporter activity
HV180_RS00145	COG0583	DNA-binding transcription factor activity
HV180_RS00150	COG2814	Major facilitator Superfamily
HV180_RS00175	COG0028	Belongs to the TPP enzyme family
HV180_RS00180	COG0440	acetolactate synthase activity
HV180_RS00185	COG2197	response regulator
HV180_RS00195	COG2271	Major facilitator Superfamily
HV180_RS00235	COG2188	Transcriptional regulator
HV180_RS00260	COG4580	involved in the transport of maltose and maltodextrins
HV180_RS00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV180_RS00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS00280	COG1609	Transcriptional regulator
HV180_RS00290	COG5464	transposase or invertase
HV180_RS00295	COG0697	spore germination
HV180_RS00300	COG1263	PTS System
HV180_RS00300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS00310	COG2814	Major facilitator Superfamily
HV180_RS00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV180_RS00325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS00340	COG1309	transcriptional regulator
HV180_RS00350	COG0583	DNA-binding transcription factor activity
HV180_RS00365	COG1464	Belongs to the NlpA lipoprotein family
HV180_RS00380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV180_RS00390	COG1064	alcohol dehydrogenase
HV180_RS00410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV180_RS00440	COG2211	Major facilitator Superfamily
HV180_RS00445	COG1501	Belongs to the glycosyl hydrolase 31 family
HV180_RS00460	COG1486	melibiose metabolic process
HV180_RS00465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS00465	COG1263	PTS System
HV180_RS00470	COG2982	Protein involved in outer membrane biogenesis
HV180_RS00475	COG2233	PERMEase
HV180_RS00480	COG0786	glutamate:sodium symporter activity
HV180_RS00495	COG3074	FtsZ-dependent cytokinesis
HV180_RS00510	COG2211	Major facilitator Superfamily
HV180_RS00515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS00525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV180_RS00545	COG3152	Membrane
HV180_RS00555	COG1494	fructose-1,6-bisphosphatase
HV180_RS00560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV180_RS00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV180_RS00570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV180_RS00590	COG2860	membrane
HV180_RS00600	COG1561	YicC-like family, N-terminal region
HV180_RS00610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HV180_RS00630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV180_RS00640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HV180_RS00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV180_RS00665	COG1519	Transferase
HV180_RS00670	COG1216	Glycosyl transferase, family 2
HV180_RS00675	COG0438	transferase activity, transferring glycosyl groups
HV180_RS00685	COG0859	PFAM glycosyl transferase family 9
HV180_RS00710	COG0859	PFAM glycosyl transferase family 9
HV180_RS00715	COG0859	PFAM glycosyl transferase family 9
HV180_RS00725	COG0156	8-amino-7-oxononanoate synthase activity
HV180_RS00735	COG0463	Glycosyl transferase, family 2
HV180_RS00740	COG2861	carbohydrate metabolic process
HV180_RS00745	COG4942	peptidase
HV180_RS00755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV180_RS00760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV180_RS00780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV180_RS00790	COG2186	Transcriptional regulator
HV180_RS00810	COG3722	fumarate hydratase activity
HV180_RS00830	COG1566	PFAM secretion protein HlyD family protein
HV180_RS00835	COG0625	glutathione transferase activity
HV180_RS00845	COG3276	selenocysteine insertion sequence binding
HV180_RS00860	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV180_RS00865	COG3977	Valine--pyruvate aminotransferase
HV180_RS00870	COG0366	Alpha amylase catalytic
HV180_RS00875	COG2992	FlgJ-related protein
HV180_RS00880	COG1609	Transcriptional regulator
HV180_RS00880	COG2207	Transcriptional regulator
HV180_RS00885	COG4214	carbohydrate transport
HV180_RS00895	COG4213	ABC transporter substrate-binding protein
HV180_RS00900	COG2115	Belongs to the xylose isomerase family
HV180_RS00905	COG1070	Carbohydrate kinase
HV180_RS00910	COG4682	membrane
HV180_RS00915	COG3274	enterobacterial common antigen metabolic process
HV180_RS00940	COG0488	(ABC) transporter
HV180_RS00945	COG1278	Cold shock
HV180_RS00950	COG2944	sequence-specific DNA binding
HV180_RS00955	COG2814	Major facilitator Superfamily
HV180_RS00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS00985	COG1609	Transcriptional regulator
HV180_RS00990	COG2885	chlorophyll binding
HV180_RS00995	COG0243	molybdopterin cofactor binding
HV180_RS01000	COG0456	acetyltransferase
HV180_RS01005	COG2818	Glycosylase
HV180_RS01010	COG5571	outer membrane autotransporter
HV180_RS01015	COG2223	nitrite transmembrane transporter activity
HV180_RS01030	COG0747	negative chemotaxis
HV180_RS01035	COG0601	transmembrane transport
HV180_RS01040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV180_RS01045	COG0444	Belongs to the ABC transporter superfamily
HV180_RS01050	COG4608	Belongs to the ABC transporter superfamily
HV180_RS01060	COG0489	protein tyrosine kinase activity
HV180_RS01070	COG1215	transferase activity, transferring glycosyl groups
HV180_RS01075	COG0457	Tetratricopeptide repeat
HV180_RS01105	COG2194	sulfuric ester hydrolase activity
HV180_RS01135	COG1215	transferase activity, transferring glycosyl groups
HV180_RS01145	COG3118	belongs to the thioredoxin family
HV180_RS01145	COG0457	Tetratricopeptide repeat
HV180_RS01150	COG2200	EAL domain
HV180_RS01150	COG2199	diguanylate cyclase activity
HV180_RS01160	COG0612	Peptidase, M16
HV180_RS01170	COG2982	Protein involved in outer membrane biogenesis
HV180_RS01175	COG0477	Major facilitator Superfamily
HV180_RS01180	COG1295	ribonuclease BN
HV180_RS01185	COG0583	DNA-binding transcription factor activity
HV180_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS01195	COG2197	response regulator
HV180_RS01205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV180_RS01215	COG1454	alcohol dehydrogenase
HV180_RS01225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV180_RS01230	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV180_RS01235	COG2205	protein histidine kinase activity
HV180_RS01240	COG0745	RESPONSE REGULATOR receiver
HV180_RS01245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV180_RS01250	COG2183	response to ionizing radiation
HV180_RS01255	COG1918	ferrous iron import across plasma membrane
HV180_RS01290	COG2610	gluconate transmembrane transporter activity
HV180_RS01310	COG0589	response to stress
HV180_RS01320	COG0306	phosphate transporter
HV180_RS01325	COG2081	HI0933 family
HV180_RS01330	COG2204	response regulator
HV180_RS01335	COG3964	amidohydrolase
HV180_RS01340	COG0471	metal ion transport
HV180_RS01345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV180_RS01350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV180_RS01360	COG2239	Acts as a magnesium transporter
HV180_RS01375	COG0444	Belongs to the ABC transporter superfamily
HV180_RS01380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV180_RS01385	COG0601	transmembrane transport
HV180_RS01390	COG0747	negative chemotaxis
HV180_RS01400	COG3479	Phenolic acid decarboxylase
HV180_RS01440	COG0628	permease
HV180_RS01445	COG0477	Major facilitator Superfamily
HV180_RS01455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV180_RS01470	COG3714	YhhN family
HV180_RS01480	COG3776	membrane
HV180_RS01485	COG0742	ribosomal rna small subunit methyltransferase
HV180_RS01490	COG0552	protein localization to endoplasmic reticulum
HV180_RS01495	COG2884	Cell division ATP-binding protein ftsE
HV180_RS01500	COG2177	Part of the ABC transporter FtsEX involved in
HV180_RS01515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV180_RS01525	COG0683	leucine binding
HV180_RS01535	COG0683	leucine binding
HV180_RS01560	COG2721	sulfolactate sulfo-lyase activity
HV180_RS01565	COG2271	Major facilitator Superfamily
HV180_RS01570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV180_RS01575	COG1414	Transcriptional regulator
HV180_RS01600	COG0584	glycerophosphoryl diester phosphodiesterase
HV180_RS01610	COG0405	Gamma-glutamyltransferase
HV180_RS01615	COG1247	-acetyltransferase
HV180_RS01625	COG0673	inositol 2-dehydrogenase activity
HV180_RS01630	COG1741	Belongs to the pirin family
HV180_RS01635	COG1609	Transcriptional regulator
HV180_RS01640	COG3265	gluconokinase activity
HV180_RS01645	COG2610	gluconate transmembrane transporter activity
HV180_RS01650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV180_RS01675	COG0058	SHG alpha-glucan phosphorylase activity
HV180_RS01680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV180_RS01695	COG1349	DNA-binding transcription factor activity
HV180_RS01700	COG4650	regulator
HV180_RS01705	COG1690	Belongs to the RtcB family
HV180_RS01720	COG0058	SHG alpha-glucan phosphorylase activity
HV180_RS01725	COG1640	4-alpha-glucanotransferase
HV180_RS01740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV180_RS01745	COG1011	Hydrolase
HV180_RS01755	COG0494	nUDIX hydrolase
HV180_RS01760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV180_RS01785	COG4796	Type ii and iii secretion system protein
HV180_RS01800	COG3266	domain, Protein
HV180_RS01805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV180_RS01810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV180_RS01840	COG2146	nitrite reductase [NAD(P)H] activity
HV180_RS01845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV180_RS01850	COG0402	S-adenosylhomocysteine deaminase activity
HV180_RS01855	COG0738	Major facilitator superfamily
HV180_RS01880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV180_RS01885	COG1289	transmembrane transporter activity
HV180_RS01895	COG1765	OsmC-like protein
HV180_RS01900	COG3954	Phosphoribulokinase
HV180_RS01910	COG0429	hydrolase of the alpha beta-hydrolase fold
HV180_RS01915	COG0488	(ABC) transporter
HV180_RS01930	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV180_RS01935	COG1047	Peptidyl-prolyl cis-trans
HV180_RS01945	COG0545	Peptidyl-prolyl cis-trans isomerase
HV180_RS01950	COG2964	Protein conserved in bacteria
HV180_RS02005	COG0051	transcription antitermination factor activity, RNA binding
HV180_RS02015	COG0088	Forms part of the polypeptide exit tunnel
HV180_RS02030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV180_RS02045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HV180_RS02095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HV180_RS02110	COG0201	protein transport
HV180_RS02125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV180_RS02135	COG0202	RNA polymerase activity
HV180_RS02140	COG0203	ribosomal protein L17
HV180_RS02150	COG0789	Transcriptional regulator
HV180_RS02185	COG0758	DNA mediated transformation
HV180_RS02195	COG0551	DNA topoisomerase type I activity
HV180_RS02215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV180_RS02255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV180_RS02260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS02265	COG1309	transcriptional regulator
HV180_RS02290	COG4145	pantothenate transmembrane transporter activity
HV180_RS02295	COG3924	membrane
HV180_RS02300	COG0439	Biotin carboxylase
HV180_RS02305	COG0511	ligase activity, forming carbon-carbon bonds
HV180_RS02320	COG0604	alcohol dehydrogenase
HV180_RS02325	COG2200	EAL domain
HV180_RS02325	COG2199	diguanylate cyclase activity
HV180_RS02330	COG1077	Cell shape determining protein MreB Mrl
HV180_RS02335	COG1792	Involved in formation and maintenance of cell shape
HV180_RS02340	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV180_RS02350	COG1530	ribonuclease E activity
HV180_RS02355	COG3164	Protein of unknown function
HV180_RS02360	COG0312	modulator of DNA gyrase
HV180_RS02365	COG1349	DNA-binding transcription factor activity
HV180_RS02370	COG0583	DNA-binding transcription factor activity
HV180_RS02385	COG1289	transmembrane transporter activity
HV180_RS02390	COG2732	(Barnase) inhibitor
HV180_RS02415	COG1802	Transcriptional regulator
HV180_RS02425	COG0471	metal ion transport
HV180_RS02430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS02435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS02450	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HV180_RS02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV180_RS02465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV180_RS02470	COG3105	Protein conserved in bacteria
HV180_RS02475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV180_RS02490	COG0625	glutathione transferase activity
HV180_RS02495	COG2969	positive regulation of protein catabolic process
HV180_RS02500	COG3539	Fimbrial protein
HV180_RS02505	COG3121	Chaperone
HV180_RS02510	COG3188	usher protein
HV180_RS02520	COG3539	Fimbrial protein
HV180_RS02525	COG0493	'glutamate synthase
HV180_RS02530	COG0069	glutamate synthase activity
HV180_RS02530	COG0067	glutamate synthase
HV180_RS02530	COG0070	glutamate synthase
HV180_RS02535	COG1242	4 iron, 4 sulfur cluster binding
HV180_RS02540	COG1312	Catalyzes the dehydration of D-mannonate
HV180_RS02545	COG2198	Histidine kinase
HV180_RS02545	COG5002	protein histidine kinase activity
HV180_RS02545	COG0784	Response regulator, receiver
HV180_RS02550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV180_RS02555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV180_RS02560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS02565	COG1660	Displays ATPase and GTPase activities
HV180_RS02570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS02575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV180_RS02580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HV180_RS02585	COG1137	ATPase activity
HV180_RS02590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV180_RS02595	COG3117	lipopolysaccharide transmembrane transporter activity
HV180_RS02600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV180_RS02610	COG0530	calcium, potassium:sodium antiporter activity
HV180_RS02615	COG1127	ABC transporter
HV180_RS02620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV180_RS02625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV180_RS02630	COG2854	intermembrane phospholipid transfer
HV180_RS02635	COG3113	response to antibiotic
HV180_RS02640	COG5007	Belongs to the BolA IbaG family
HV180_RS02650	COG3423	Transcriptional regulator
HV180_RS02655	COG0142	geranyltranstransferase activity
HV180_RS02670	COG0697	spore germination
HV180_RS02680	COG2027	D-alanyl-D-alanine carboxypeptidase
HV180_RS02685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV180_RS02690	COG1534	Rna-binding protein
HV180_RS02700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV180_RS02705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV180_RS02715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV180_RS02740	COG0195	Participates in both transcription termination and antitermination
HV180_RS02745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV180_RS02780	COG0513	Belongs to the DEAD box helicase family
HV180_RS02785	COG0814	amino acid
HV180_RS02795	COG3034	peptidoglycan biosynthetic process
HV180_RS02800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV180_RS02805	COG0826	peptidase U32
HV180_RS02810	COG0826	peptidase U32
HV180_RS02815	COG3154	lipid carrier protein
HV180_RS02820	COG3153	acetyltransferase
HV180_RS02825	COG2827	Endonuclease containing a URI domain
HV180_RS02835	COG0693	protein deglycase activity
HV180_RS02840	COG0702	epimerase
HV180_RS02845	COG0701	Predicted permease
HV180_RS02855	COG2823	Periplasmic or secreted lipoprotein
HV180_RS02875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV180_RS02880	COG3539	Fimbrial protein
HV180_RS02885	COG3188	usher protein
HV180_RS02890	COG3121	Chaperone
HV180_RS02895	COG3539	Fimbrial protein
HV180_RS02905	COG1063	alcohol dehydrogenase
HV180_RS02910	COG3775	system Galactitol-specific IIC component
HV180_RS02915	COG3414	Phosphotransferase system galactitol-specific IIB component
HV180_RS02920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS02925	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HV180_RS02930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS02930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS02935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS02935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS02935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS02950	COG1349	DNA-binding transcription factor activity
HV180_RS02955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS02960	COG2721	sulfolactate sulfo-lyase activity
HV180_RS02965	COG2271	Major facilitator Superfamily
HV180_RS02975	COG2084	Dehydrogenase
HV180_RS02980	COG1929	Belongs to the glycerate kinase type-1 family
HV180_RS03005	COG1741	Belongs to the pirin family
HV180_RS03010	COG0583	DNA-binding transcription factor activity
HV180_RS03015	COG3152	Membrane
HV180_RS03030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV180_RS03035	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV180_RS03045	COG3299	homolog of phage Mu protein gp47
HV180_RS03055	COG4384	Bacteriophage Mu Gp45 protein
HV180_RS03075	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
HV180_RS03085	COG4386	tail sheath protein
HV180_RS03115	COG4397	Mu-like prophage major head subunit gpT
HV180_RS03135	COG4373	Mu-like prophage FluMu protein gp28
HV180_RS03150	COG0640	Transcriptional regulator
HV180_RS03190	COG4382	Mu-like prophage protein Gp16
HV180_RS03220	COG2842	Transposition protein
HV180_RS03240	COG0435	Glutathione S-transferase
HV180_RS03245	COG2259	Doxx family
HV180_RS03255	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV180_RS03260	COG4575	ribosome binding
HV180_RS03265	COG1422	Protein of unknown function (DUF1090)
HV180_RS03275	COG0586	Pfam SNARE associated Golgi protein
HV180_RS03280	COG2186	Transcriptional regulator
HV180_RS03285	COG2271	Major facilitator Superfamily
HV180_RS03295	COG2721	sulfolactate sulfo-lyase activity
HV180_RS03315	COG0673	inositol 2-dehydrogenase activity
HV180_RS03330	COG1451	nucleotide metabolic process
HV180_RS03335	COG3507	Belongs to the glycosyl hydrolase 43 family
HV180_RS03345	COG2211	Major facilitator Superfamily
HV180_RS03360	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV180_RS03360	COG1902	pentaerythritol trinitrate reductase activity
HV180_RS03380	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS03405	COG3408	Glycogen debranching enzyme
HV180_RS03405	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HV180_RS03415	COG0531	amino acid
HV180_RS03420	COG0531	amino acid
HV180_RS03425	COG2731	YhcH YjgK YiaL family protein
HV180_RS03430	COG3250	beta-galactosidase activity
HV180_RS03435	COG1609	Transcriptional regulator
HV180_RS03440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV180_RS03450	COG1695	Transcriptional regulator
HV180_RS03455	COG2375	cellular response to nickel ion
HV180_RS03470	COG1461	Dihydroxyacetone kinase
HV180_RS03475	COG2376	Dihydroxyacetone kinase
HV180_RS03505	COG4974	Belongs to the 'phage' integrase family
HV180_RS03570	COG4695	Portal protein
HV180_RS03750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV180_RS03805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV180_RS03820	COG4991	sh3 domain protein
HV180_RS03825	COG3025	triphosphatase activity
HV180_RS03845	COG2960	long-chain fatty acid transporting porin activity
HV180_RS03860	COG3384	dioxygenase
HV180_RS03865	COG0754	glutathionylspermidine amidase activity
HV180_RS03880	COG0494	nUDIX hydrolase
HV180_RS03885	COG3151	Protein conserved in bacteria
HV180_RS03890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV180_RS03895	COG3150	esterase
HV180_RS03900	COG0187	DNA topoisomerase II activity
HV180_RS03905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV180_RS03910	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV180_RS03915	COG0642	Histidine kinase
HV180_RS03925	COG3111	PFAM Bacterial OB fold (BOF) protein
HV180_RS03935	COG0204	Acyl-transferase
HV180_RS03940	COG2132	Multicopper oxidase
HV180_RS03945	COG1032	radical SAM domain protein
HV180_RS03960	COG1979	alcohol dehydrogenase
HV180_RS03965	COG2207	Transcriptional regulator
HV180_RS03970	COG0586	Pfam SNARE associated Golgi protein
HV180_RS03975	COG0626	cystathionine gamma-synthase activity
HV180_RS03985	COG0848	biopolymer transport protein
HV180_RS03990	COG2211	Major facilitator Superfamily
HV180_RS04015	COG0625	glutathione transferase activity
HV180_RS04025	COG0754	glutathionylspermidine amidase activity
HV180_RS04030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV180_RS04050	COG0583	DNA-binding transcription factor activity
HV180_RS04055	COG0626	cystathionine gamma-synthase activity
HV180_RS04070	COG0471	metal ion transport
HV180_RS04080	COG3188	usher protein
HV180_RS04085	COG3121	Chaperone
HV180_RS04105	COG3710	Transcriptional regulator
HV180_RS04140	COG1811	Na channel or pump
HV180_RS04145	COG1982	Orn Lys Arg decarboxylase major
HV180_RS04150	COG2211	Major facilitator Superfamily
HV180_RS04165	COG1194	a g-specific adenine glycosylase
HV180_RS04175	COG3171	Protein conserved in bacteria
HV180_RS04195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HV180_RS04200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV180_RS04205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV180_RS04220	COG0762	integral membrane protein
HV180_RS04225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV180_RS04230	COG2805	Type II/IV secretion system protein
HV180_RS04235	COG2197	response regulator
HV180_RS04250	COG0189	ligase activity
HV180_RS04255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV180_RS04260	COG2356	endonuclease I
HV180_RS04270	COG2814	Major facilitator Superfamily
HV180_RS04290	COG1166	arginine decarboxylase activity
HV180_RS04305	COG2146	nitrite reductase [NAD(P)H] activity
HV180_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS04325	COG1414	Transcriptional regulator
HV180_RS04340	COG2814	Major facilitator Superfamily
HV180_RS04355	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS04360	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HV180_RS04380	COG0501	Belongs to the peptidase M48B family
HV180_RS04385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV180_RS04390	COG1122	ATPase activity
HV180_RS04395	COG1122	ATPase activity
HV180_RS04425	COG0191	fructose-bisphosphate aldolase activity
HV180_RS04430	COG0668	transmembrane transport
HV180_RS04435	COG1279	arginine transmembrane transporter activity
HV180_RS04440	COG2968	Membrane
HV180_RS04445	COG0583	DNA-binding transcription factor activity
HV180_RS04450	COG0427	acetyl-CoA hydrolase
HV180_RS04455	COG1024	Enoyl-CoA hydratase
HV180_RS04460	COG1703	isobutyryl-CoA mutase activity
HV180_RS04465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV180_RS04465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV180_RS04480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV180_RS04485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV180_RS04505	COG0006	proline dipeptidase activity
HV180_RS04510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV180_RS04515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV180_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS04540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV180_RS04545	COG2723	6-phospho-beta-galactosidase activity
HV180_RS04550	COG1737	Transcriptional regulator
HV180_RS04560	COG1272	protein, Hemolysin III
HV180_RS04575	COG3716	PTS system mannose fructose sorbose family IID component
HV180_RS04580	COG3715	PTS system
HV180_RS04585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS04585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS04605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV180_RS04615	COG0716	FMN binding
HV180_RS04630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV180_RS04650	COG1811	Na channel or pump
HV180_RS04660	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV180_RS04665	COG0583	DNA-binding transcription factor activity
HV180_RS04670	COG4942	peptidase
HV180_RS04695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS04695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS04700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS04705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS04705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS04705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV180_RS04710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV180_RS04715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV180_RS04725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS04730	COG2207	Transcriptional regulator
HV180_RS04735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS04740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS04740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV180_RS04740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS04780	COG2200	EAL domain
HV180_RS04795	COG3539	Fimbrial protein
HV180_RS04800	COG3121	Chaperone
HV180_RS04825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV180_RS04855	COG3188	usher protein
HV180_RS04865	COG3121	Chaperone
HV180_RS04880	COG2046	Belongs to the sulfate adenylyltransferase family
HV180_RS04880	COG0529	Catalyzes the synthesis of activated sulfate
HV180_RS04890	COG2223	nitrite transmembrane transporter activity
HV180_RS04895	COG3835	regulator
HV180_RS04900	COG1929	Belongs to the glycerate kinase type-1 family
HV180_RS04945	COG0738	Major facilitator superfamily
HV180_RS04950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS04955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV180_RS04960	COG1349	DNA-binding transcription factor activity
HV180_RS04980	COG1349	DNA-binding transcription factor activity
HV180_RS04985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS04990	COG3104	oligopeptide transport
HV180_RS04995	COG1538	Outer membrane efflux protein
HV180_RS05000	COG1289	transmembrane transporter activity
HV180_RS05015	COG3592	Divergent 4Fe-4S mono-cluster
HV180_RS05020	COG2388	GCN5-related N-acetyl-transferase
HV180_RS05030	COG3539	Fimbrial protein
HV180_RS05035	COG3539	Fimbrial protein
HV180_RS05040	COG3539	Fimbrial protein
HV180_RS05045	COG3188	usher protein
HV180_RS05050	COG3121	Chaperone
HV180_RS05055	COG3539	Fimbrial protein
HV180_RS05065	COG4974	Belongs to the 'phage' integrase family
HV180_RS05070	COG0582	viral genome integration into host DNA
HV180_RS05080	COG1522	sequence-specific DNA binding
HV180_RS05085	COG1846	Transcriptional regulator
HV180_RS05090	COG0697	spore germination
HV180_RS05105	COG0640	Transcriptional regulator
HV180_RS05150	COG0667	Aldo Keto reductase
HV180_RS05155	COG0814	amino acid
HV180_RS05170	COG0183	Belongs to the thiolase family
HV180_RS05180	COG0823	Involved in the tonB-independent uptake of proteins
HV180_RS05185	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS05190	COG2814	Major facilitator Superfamily
HV180_RS05215	COG0823	Involved in the tonB-independent uptake of proteins
HV180_RS05225	COG3842	ATPase activity
HV180_RS05230	COG0395	ABC-type sugar transport system, permease component
HV180_RS05235	COG1175	transmembrane transport
HV180_RS05245	COG1794	racemase activity, acting on amino acids and derivatives
HV180_RS05250	COG0583	DNA-binding transcription factor activity
HV180_RS05260	COG1609	Transcriptional regulator
HV180_RS05265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS05270	COG2723	6-phospho-beta-galactosidase activity
HV180_RS05275	COG2186	Transcriptional regulator
HV180_RS05285	COG1609	Transcriptional regulator
HV180_RS05300	COG0667	Aldo Keto reductase
HV180_RS05310	COG0861	Integral membrane protein TerC family
HV180_RS05345	COG2165	general secretion pathway protein
HV180_RS05350	COG4795	General secretion pathway protein
HV180_RS05360	COG4967	type IV pilus modification protein PilV
HV180_RS05365	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV180_RS05370	COG1025	Belongs to the peptidase M16 family
HV180_RS05375	COG1074	ATP-dependent DNA helicase activity
HV180_RS05380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV180_RS05385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV180_RS05385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV180_RS05390	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV180_RS05395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV180_RS05425	COG4656	Part of a membrane complex involved in electron transport
HV180_RS05460	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HV180_RS05625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV180_RS05630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV180_RS05635	COG2166	iron-sulfur cluster assembly
HV180_RS05640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV180_RS05650	COG0583	DNA-binding transcription factor activity
HV180_RS05655	COG2363	Small membrane protein
HV180_RS05665	COG1349	DNA-binding transcription factor activity
HV180_RS05685	COG0738	Major facilitator superfamily
HV180_RS05690	COG0235	Class ii aldolase
HV180_RS05700	COG3829	transcription factor binding
HV180_RS05705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV180_RS05720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV180_RS05725	COG1760	l-serine dehydratase
HV180_RS05730	COG0814	amino acid
HV180_RS05735	COG1611	Belongs to the LOG family
HV180_RS05750	COG3098	single-species biofilm formation
HV180_RS05755	COG0564	pseudouridine synthase activity
HV180_RS05760	COG0716	FMN binding
HV180_RS05765	COG2271	Major facilitator Superfamily
HV180_RS05770	COG4948	Mandelate Racemase Muconate Lactonizing
HV180_RS05775	COG4948	Mandelate Racemase Muconate Lactonizing
HV180_RS05780	COG1929	Belongs to the glycerate kinase type-1 family
HV180_RS05785	COG4999	Histidine kinase
HV180_RS05785	COG3437	response regulator, receiver
HV180_RS05785	COG3850	Histidine kinase
HV180_RS05785	COG2205	protein histidine kinase activity
HV180_RS05795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV180_RS05805	COG3956	TIGRFAM MazG family protein
HV180_RS05825	COG0602	queuosine metabolic process
HV180_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS05835	COG0720	synthase
HV180_RS05880	COG2234	aminopeptidase activity
HV180_RS05940	COG1388	LysM domain
HV180_RS05940	COG4942	peptidase
HV180_RS05945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV180_RS05955	COG0477	Major facilitator Superfamily
HV180_RS05975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV180_RS05995	COG3539	Fimbrial protein
HV180_RS06005	COG3188	usher protein
HV180_RS06010	COG3121	Chaperone
HV180_RS06020	COG3539	Fimbrial protein
HV180_RS06025	COG3539	Fimbrial protein
HV180_RS06050	COG1132	(ABC) transporter
HV180_RS06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS06080	COG2842	Transposition protein
HV180_RS06110	COG4382	Mu-like prophage protein Gp16
HV180_RS06150	COG0640	Transcriptional regulator
HV180_RS06165	COG4373	Mu-like prophage FluMu protein gp28
HV180_RS06185	COG4397	Mu-like prophage major head subunit gpT
HV180_RS06215	COG4386	tail sheath protein
HV180_RS06225	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
HV180_RS06245	COG4384	Bacteriophage Mu Gp45 protein
HV180_RS06255	COG3299	homolog of phage Mu protein gp47
HV180_RS06265	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV180_RS06270	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV180_RS06290	COG1538	Outer membrane efflux protein
HV180_RS06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV180_RS06340	COG1454	alcohol dehydrogenase
HV180_RS06345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HV180_RS06350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS06355	COG4558	Periplasmic binding protein
HV180_RS06360	COG3720	iron ion transport
HV180_RS06380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV180_RS06385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV180_RS06390	COG1121	(ABC) transporter
HV180_RS06400	COG1609	Transcriptional regulator
HV180_RS06405	COG1940	carbohydrate kinase activity
HV180_RS06410	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV180_RS06415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS06420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS06425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS06430	COG4580	involved in the transport of maltose and maltodextrins
HV180_RS06440	COG2723	6-phospho-beta-galactosidase activity
HV180_RS06445	COG2755	lipolytic protein G-D-S-L family
HV180_RS06445	COG0657	acetylesterase activity
HV180_RS06455	COG0309	Hydrogenase expression formation protein (HypE)
HV180_RS06460	COG0409	Hydrogenase expression formation protein
HV180_RS06465	COG0298	carbon dioxide binding
HV180_RS06470	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV180_RS06485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV180_RS06490	COG0651	ATP synthesis coupled electron transport
HV180_RS06495	COG0650	Formate hydrogenlyase subunit 4
HV180_RS06500	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV180_RS06500	COG3261	NADH dehydrogenase
HV180_RS06505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV180_RS06510	COG3260	NADH ubiquinone oxidoreductase 20
HV180_RS06520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV180_RS06525	COG2723	6-phospho-beta-galactosidase activity
HV180_RS06530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS06530	COG1263	PTS System
HV180_RS06535	COG1609	Transcriptional regulator
HV180_RS06540	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV180_RS06545	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV180_RS06550	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV180_RS06580	COG1349	DNA-binding transcription factor activity
HV180_RS06585	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS06600	COG3732	PTS system glucitol sorbitol-specific
HV180_RS06605	COG3730	PTS system glucitol sorbitol-specific
HV180_RS06610	COG2951	lytic endotransglycosylase activity
HV180_RS06620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV180_RS06625	COG0803	Belongs to the bacterial solute-binding protein 9 family
HV180_RS06635	COG1546	Belongs to the CinA family
HV180_RS06655	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV180_RS06685	COG2823	Periplasmic or secreted lipoprotein
HV180_RS06690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV180_RS06695	COG1238	metal cluster binding
HV180_RS06715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV180_RS06720	COG2814	Major facilitator Superfamily
HV180_RS06725	COG1566	PFAM secretion protein HlyD family protein
HV180_RS06730	COG1846	Transcriptional regulator
HV180_RS06740	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV180_RS06750	COG4176	ABC-type proline glycine betaine transport system permease component
HV180_RS06765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV180_RS06775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV180_RS06780	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV180_RS06790	COG4575	ribosome binding
HV180_RS06815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV180_RS06820	COG0640	Transcriptional regulator
HV180_RS06825	COG0671	phosphoesterase, PA-phosphatase related
HV180_RS06830	COG3284	Transcriptional regulator
HV180_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS06845	COG3121	Chaperone
HV180_RS06850	COG3188	usher protein
HV180_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS06880	COG2814	Major facilitator Superfamily
HV180_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS06895	COG0235	Class ii aldolase
HV180_RS06900	COG1126	abc transporter atp-binding protein
HV180_RS06905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS07005	COG2003	Belongs to the UPF0758 family
HV180_RS07040	COG4735	regulation of single-species biofilm formation
HV180_RS07050	COG3311	Transcriptional regulator
HV180_RS07065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV180_RS07070	COG1061	Type III restriction enzyme res subunit
HV180_RS07075	COG1002	Type II restriction enzyme, methylase subunits
HV180_RS07080	COG0582	viral genome integration into host DNA
HV180_RS07095	COG2867	negative regulation of translational initiation
HV180_RS07110	COG0497	DNA recombination
HV180_RS07125	COG4536	flavin adenine dinucleotide binding
HV180_RS07130	COG4137	Cytochrome C assembly protein
HV180_RS07135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV180_RS07170	COG2885	chlorophyll binding
HV180_RS07175	COG2199	diguanylate cyclase activity
HV180_RS07185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV180_RS07190	COG0287	Prephenate dehydrogenase
HV180_RS07190	COG1605	Chorismate mutase
HV180_RS07200	COG1605	Chorismate mutase
HV180_RS07200	COG0077	Prephenate dehydratase
HV180_RS07210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV180_RS07215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV180_RS07230	COG0542	response to heat
HV180_RS07260	COG0477	Major facilitator Superfamily
HV180_RS07265	COG5544	Lipoprotein
HV180_RS07270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV180_RS07285	COG3118	belongs to the thioredoxin family
HV180_RS07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV180_RS07305	COG0513	Belongs to the DEAD box helicase family
HV180_RS07315	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV180_RS07330	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV180_RS07335	COG3026	antisigma factor binding
HV180_RS07340	COG3086	response to oxidative stress
HV180_RS07350	COG0681	Belongs to the peptidase S26 family
HV180_RS07370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV180_RS07380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV180_RS07385	COG0583	DNA-binding transcription factor activity
HV180_RS07390	COG2223	nitrite transmembrane transporter activity
HV180_RS07395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HV180_RS07400	COG1737	Transcriptional regulator
HV180_RS07405	COG0560	Phosphoserine phosphatase
HV180_RS07420	COG0047	phosphoribosylformylglycinamidine synthase activity
HV180_RS07420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HV180_RS07425	COG2205	protein histidine kinase activity
HV180_RS07430	COG3170	Tfp pilus assembly protein FimV
HV180_RS07435	COG2204	response regulator
HV180_RS07440	COG0347	Belongs to the P(II) protein family
HV180_RS07445	COG0371	Dehydrogenase
HV180_RS07450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV180_RS07475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV180_RS07475	COG1017	nitric oxide dioxygenase activity
HV180_RS07485	COG2259	Doxx family
HV180_RS07490	COG1940	carbohydrate kinase activity
HV180_RS07495	COG0457	Tetratricopeptide repeat
HV180_RS07500	COG1879	ABC-type sugar transport system periplasmic component
HV180_RS07505	COG1129	ABC transporter
HV180_RS07510	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS07515	COG1063	alcohol dehydrogenase
HV180_RS07520	COG2017	converts alpha-aldose to the beta-anomer
HV180_RS07525	COG2814	Major facilitator Superfamily
HV180_RS07530	COG3711	transcriptional antiterminator
HV180_RS07535	COG3683	transport system, periplasmic component
HV180_RS07540	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV180_RS07565	COG0822	iron-sulfur transferase activity
HV180_RS07585	COG0633	Ferredoxin
HV180_RS07590	COG2975	iron-sulfur cluster assembly
HV180_RS07605	COG2897	thiosulfate sulfurtransferase activity
HV180_RS07610	COG1473	amidohydrolase
HV180_RS07620	COG2373	Large extracellular alpha-helical protein
HV180_RS07625	COG4953	penicillin-binding protein 1C
HV180_RS07655	COG2976	Protein conserved in bacteria
HV180_RS07670	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HV180_RS07680	COG1645	bacterial-type flagellum-dependent swarming motility
HV180_RS07695	COG1570	exodeoxyribonuclease VII activity
HV180_RS07700	COG0517	IMP dehydrogenase activity
HV180_RS07700	COG0516	GMP reductase activity
HV180_RS07705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HV180_RS07705	COG0519	Catalyzes the synthesis of GMP from XMP
HV180_RS07745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV180_RS07950	COG3617	BRO family, N-terminal domain
HV180_RS07980	COG3179	chitinase
HV180_RS07990	COG3121	Chaperone
HV180_RS08010	COG3121	Chaperone
HV180_RS08050	COG0583	DNA-binding transcription factor activity
HV180_RS08055	COG0583	DNA-binding transcription factor activity
HV180_RS08075	COG2200	EAL domain
HV180_RS08090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV180_RS08105	COG2723	6-phospho-beta-galactosidase activity
HV180_RS08120	COG2233	PERMEase
HV180_RS08130	COG1393	Belongs to the ArsC family
HV180_RS08135	COG4783	chaperone-mediated protein folding
HV180_RS08140	COG0628	permease
HV180_RS08145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV180_RS08150	COG2716	regulation of RNA biosynthetic process
HV180_RS08160	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV180_RS08170	COG2321	neutral zinc metallopeptidase
HV180_RS08180	COG0400	carboxylic ester hydrolase activity
HV180_RS08200	COG1393	Belongs to the ArsC family
HV180_RS08210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV180_RS08215	COG0493	'glutamate synthase
HV180_RS08215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV180_RS08225	COG5342	invasion associated locus B
HV180_RS08230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV180_RS08240	COG4810	utilization protein
HV180_RS08320	COG2207	Transcriptional regulator
HV180_RS08330	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV180_RS08350	COG2837	iron assimilation
HV180_RS08355	COG4150	thiosulfate binding
HV180_RS08360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV180_RS08365	COG4208	sulfate ABC transporter
HV180_RS08370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV180_RS08420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HV180_RS08440	COG3530	Putative quorum-sensing-regulated virulence factor
HV180_RS08445	COG0385	Bile acid
HV180_RS08450	COG0583	DNA-binding transcription factor activity
HV180_RS08455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV180_RS08460	COG2211	Major facilitator Superfamily
HV180_RS08465	COG0583	DNA-binding transcription factor activity
HV180_RS08495	COG3415	Transposase
HV180_RS08500	COG3415	Transposase
HV180_RS08515	COG2200	EAL domain
HV180_RS08515	COG2199	diguanylate cyclase activity
HV180_RS08520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV180_RS08535	COG0667	Aldo Keto reductase
HV180_RS08540	COG3961	Belongs to the TPP enzyme family
HV180_RS08555	COG3279	Response regulator of the LytR AlgR family
HV180_RS08560	COG3275	phosphorelay sensor kinase activity
HV180_RS08565	COG0436	Aminotransferase
HV180_RS08575	COG2807	transmembrane transport
HV180_RS08580	COG0583	DNA-binding transcription factor activity
HV180_RS08595	COG2116	formate transmembrane transporter activity
HV180_RS08610	COG3691	Protein conserved in bacteria
HV180_RS08625	COG2062	phosphohistidine phosphatase, SixA
HV180_RS08650	COG0730	response to heat
HV180_RS08655	COG3101	peptidyl-lysine hydroxylation
HV180_RS08670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV180_RS08690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV180_RS08700	COG0586	Pfam SNARE associated Golgi protein
HV180_RS08710	COG0285	dihydrofolate synthase activity
HV180_RS08715	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV180_RS08720	COG1286	toxin biosynthetic process
HV180_RS08725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV180_RS08735	COG2211	Major facilitator Superfamily
HV180_RS08740	COG1940	carbohydrate kinase activity
HV180_RS08745	COG1609	Transcriptional regulator
HV180_RS08750	COG0163	prenyltransferase activity
HV180_RS08770	COG4160	amino acid transport
HV180_RS08775	COG4598	ABC transporter
HV180_RS08795	COG1090	epimerase
HV180_RS08800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV180_RS08805	COG0625	glutathione transferase activity
HV180_RS08810	COG0625	glutathione transferase activity
HV180_RS08815	COG0622	Phosphoesterase
HV180_RS08825	COG1609	Transcriptional regulator
HV180_RS08830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS08840	COG3037	sugar-specific permease SgaT UlaA
HV180_RS08845	COG3959	Transketolase, thiamine diphosphate binding domain
HV180_RS08850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV180_RS08875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV180_RS08880	COG0490	domain, Protein
HV180_RS08880	COG0471	metal ion transport
HV180_RS08890	COG0436	Aminotransferase
HV180_RS08895	COG0583	DNA-binding transcription factor activity
HV180_RS08945	COG0839	Belongs to the complex I subunit 6 family
HV180_RS08950	COG0713	ATP synthesis coupled electron transport
HV180_RS08955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV180_RS08960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV180_RS08970	COG0582	viral genome integration into host DNA
HV180_RS09000	COG0582	viral genome integration into host DNA
HV180_RS09010	COG2153	protein acetylation
HV180_RS09015	COG1169	isochorismate synthase
HV180_RS09045	COG3647	Membrane
HV180_RS09070	COG0642	Histidine kinase
HV180_RS09100	COG1414	Transcriptional regulator
HV180_RS09110	COG2271	Major facilitator Superfamily
HV180_RS09120	COG0247	lactate metabolic process
HV180_RS09130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV180_RS09135	COG2271	Major facilitator Superfamily
HV180_RS09140	COG0584	glycerophosphoryl diester phosphodiesterase
HV180_RS09145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV180_RS09170	COG0784	Response regulator, receiver
HV180_RS09170	COG2205	protein histidine kinase activity
HV180_RS09180	COG0642	Histidine kinase
HV180_RS09180	COG2198	Histidine kinase
HV180_RS09195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV180_RS09195	COG2169	Transcriptional regulator
HV180_RS09200	COG3145	DNA-N1-methyladenine dioxygenase activity
HV180_RS09205	COG4615	Cyclic peptide transporter
HV180_RS09210	COG2239	Acts as a magnesium transporter
HV180_RS09215	COG0659	secondary active sulfate transmembrane transporter activity
HV180_RS09230	COG0628	permease
HV180_RS09295	COG1349	DNA-binding transcription factor activity
HV180_RS09300	COG0494	nUDIX hydrolase
HV180_RS09310	COG1061	Type III restriction enzyme res subunit
HV180_RS09315	COG1187	pseudouridine synthase activity
HV180_RS09320	COG2814	Major facilitator Superfamily
HV180_RS09330	COG4172	Belongs to the ABC transporter superfamily
HV180_RS09335	COG4239	(ABC) transporter, permease
HV180_RS09340	COG4174	ABC transporter (Permease)
HV180_RS09345	COG4166	transmembrane transport
HV180_RS09350	COG2200	EAL domain
HV180_RS09355	COG0791	NLP P60 protein
HV180_RS09360	COG0671	phosphoesterase, PA-phosphatase related
HV180_RS09365	COG0523	cobalamin synthesis protein
HV180_RS09370	COG0246	Mannitol dehydrogenase
HV180_RS09375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HV180_RS09390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS09390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS09395	COG1105	Belongs to the carbohydrate kinase PfkB family
HV180_RS09400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS09400	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV180_RS09400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS09405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS09410	COG2313	pseudouridylate synthase activity
HV180_RS09415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV180_RS09420	COG1522	sequence-specific DNA binding
HV180_RS09420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS09430	COG2855	membrane
HV180_RS09435	COG0583	DNA-binding transcription factor activity
HV180_RS09450	COG0833	amino acid
HV180_RS09455	COG4771	TonB-dependent receptor
HV180_RS09470	COG2311	Membrane
HV180_RS09485	COG1129	ABC transporter
HV180_RS09495	COG2949	membrane
HV180_RS09505	COG1346	cytolysis
HV180_RS09515	COG0583	DNA-binding transcription factor activity
HV180_RS09520	COG2271	Major facilitator Superfamily
HV180_RS09535	COG0625	glutathione transferase activity
HV180_RS09540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV180_RS09545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV180_RS09550	COG3711	transcriptional antiterminator
HV180_RS09560	COG2723	6-phospho-beta-galactosidase activity
HV180_RS09565	COG2226	methyltransferase
HV180_RS09570	COG1538	Outer membrane efflux protein
HV180_RS09575	COG0586	Pfam SNARE associated Golgi protein
HV180_RS09585	COG1686	Belongs to the peptidase S11 family
HV180_RS09595	COG0277	FAD linked oxidase domain protein
HV180_RS09600	COG1472	Belongs to the glycosyl hydrolase 3 family
HV180_RS09605	COG1732	Glycine betaine
HV180_RS09610	COG1174	glycine betaine transport
HV180_RS09615	COG1125	glycine betaine transport
HV180_RS09620	COG1174	glycine betaine transport
HV180_RS09630	COG0789	Transcriptional regulator
HV180_RS09635	COG3275	phosphorelay sensor kinase activity
HV180_RS09645	COG4807	Protein conserved in bacteria
HV180_RS09650	COG4808	Protein conserved in bacteria
HV180_RS09655	COG4715	Zinc finger, swim domain protein
HV180_RS09660	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HV180_RS09665	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HV180_RS09670	COG0714	Associated with various cellular activities
HV180_RS09675	COG3831	ATPase activity
HV180_RS09680	COG3831	ATPase activity
HV180_RS09685	COG3831	ATPase activity
HV180_RS09690	COG3831	ATPase activity
HV180_RS09715	COG5455	response to cobalt ion
HV180_RS09720	COG0583	DNA-binding transcription factor activity
HV180_RS09725	COG2252	PERMEase
HV180_RS09735	COG0583	DNA-binding transcription factor activity
HV180_RS09745	COG0351	phosphomethylpyrimidine kinase
HV180_RS09750	COG1830	Aldolase
HV180_RS09755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV180_RS09780	COG1070	Carbohydrate kinase
HV180_RS09790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV180_RS09795	COG4948	Mandelate Racemase Muconate Lactonizing
HV180_RS09800	COG0747	negative chemotaxis
HV180_RS09805	COG0601	transmembrane transport
HV180_RS09815	COG0444	Belongs to the ABC transporter superfamily
HV180_RS09820	COG4608	Belongs to the ABC transporter superfamily
HV180_RS09860	COG0745	RESPONSE REGULATOR receiver
HV180_RS09865	COG2205	protein histidine kinase activity
HV180_RS09895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS09900	COG4215	(ABC) transporter
HV180_RS09910	COG1522	sequence-specific DNA binding
HV180_RS09920	COG1301	dicarboxylic acid transport
HV180_RS09940	COG5002	protein histidine kinase activity
HV180_RS09945	COG0372	Belongs to the citrate synthase family
HV180_RS09950	COG0443	Heat shock 70 kDa protein
HV180_RS09955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV180_RS09970	COG2982	Protein involved in outer membrane biogenesis
HV180_RS09975	COG1253	flavin adenine dinucleotide binding
HV180_RS10015	COG2244	polysaccharide biosynthetic process
HV180_RS10115	COG0438	transferase activity, transferring glycosyl groups
HV180_RS10140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV180_RS10155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV180_RS10170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV180_RS10175	COG0583	DNA-binding transcription factor activity
HV180_RS10185	COG0531	amino acid
HV180_RS10190	COG0640	Transcriptional regulator
HV180_RS10195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV180_RS10200	COG2925	Exonuclease
HV180_RS10230	COG1289	transmembrane transporter activity
HV180_RS10250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HV180_RS10260	COG2814	Major facilitator Superfamily
HV180_RS10265	COG0673	inositol 2-dehydrogenase activity
HV180_RS10270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS10270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS10275	COG1082	Xylose isomerase domain protein TIM barrel
HV180_RS10285	COG1942	4-Oxalocrotonate Tautomerase
HV180_RS10290	COG0583	DNA-binding transcription factor activity
HV180_RS10295	COG0095	Lipoate-protein ligase
HV180_RS10300	COG0477	Major facilitator Superfamily
HV180_RS10310	COG3300	MHYT domain
HV180_RS10310	COG5001	Diguanylate cyclase
HV180_RS10315	COG3615	Tellurite resistance protein tehB
HV180_RS10325	COG2188	Transcriptional regulator
HV180_RS10330	COG1263	PTS System
HV180_RS10330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS10345	COG3539	Fimbrial protein
HV180_RS10350	COG3539	Fimbrial protein
HV180_RS10355	COG3539	Fimbrial protein
HV180_RS10360	COG3188	usher protein
HV180_RS10365	COG3121	Chaperone
HV180_RS10370	COG3539	Fimbrial protein
HV180_RS10410	COG1376	ErfK ybiS ycfS ynhG family protein
HV180_RS10425	COG2814	Major facilitator Superfamily
HV180_RS10455	COG0534	Mate efflux family protein
HV180_RS10465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV180_RS10495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV180_RS10505	COG0589	response to stress
HV180_RS10515	COG2819	hydrolase of the alpha beta superfamily
HV180_RS10545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV180_RS10555	COG1418	mRNA catabolic process
HV180_RS10560	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV180_RS10565	COG3727	T/G mismatch-specific endonuclease activity
HV180_RS10570	COG0697	spore germination
HV180_RS10575	COG2354	Protein conserved in bacteria
HV180_RS10580	COG5475	Uncharacterized small protein (DUF2158)
HV180_RS10610	COG0366	Alpha amylase catalytic
HV180_RS10635	COG2197	response regulator
HV180_RS10645	COG2197	response regulator
HV180_RS10675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV180_RS10680	COG3318	Belongs to the UPF0149 family
HV180_RS10680	COG3012	SEC-C Motif Domain Protein
HV180_RS10685	COG0814	amino acid
HV180_RS10695	COG1528	Iron-storage protein
HV180_RS10705	COG0477	Major facilitator Superfamily
HV180_RS10725	COG1528	Iron-storage protein
HV180_RS10735	COG1879	ABC-type sugar transport system periplasmic component
HV180_RS10745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS10775	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV180_RS10785	COG3102	Protein conserved in bacteria
HV180_RS10805	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV180_RS10810	COG1801	Protein of unknown function DUF72
HV180_RS10815	COG1335	isochorismatase
HV180_RS10825	COG0494	nUDIX hydrolase
HV180_RS10830	COG0217	transcriptional regulatory protein
HV180_RS10855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV180_RS10865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV180_RS10870	COG0739	heme binding
HV180_RS10875	COG1560	Kdo2-lipid A biosynthetic process
HV180_RS10885	COG1737	Transcriptional regulator
HV180_RS10890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV180_RS10895	COG0129	dihydroxy-acid dehydratase activity
HV180_RS10900	COG0800	Aldolase
HV180_RS10910	COG3141	response to X-ray
HV180_RS10915	COG2979	Protein of unknown function (DUF533)
HV180_RS10920	COG1770	oligopeptidase
HV180_RS10925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV180_RS10935	COG2372	response to copper ion
HV180_RS10940	COG1276	copper resistance
HV180_RS10980	COG2990	Protein conserved in bacteria
HV180_RS11005	COG3008	intermembrane lipid transfer
HV180_RS11010	COG2995	paraquat-inducible protein a
HV180_RS11015	COG1956	GAF domain-containing protein
HV180_RS11035	COG2814	Major facilitator Superfamily
HV180_RS11040	COG1414	Transcriptional regulator
HV180_RS11070	COG0768	penicillin binding
HV180_RS11075	COG2226	methyltransferase
HV180_RS11090	COG3716	PTS system mannose fructose sorbose family IID component
HV180_RS11095	COG3715	PTS system
HV180_RS11100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS11100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS11105	COG1253	flavin adenine dinucleotide binding
HV180_RS11110	COG2200	EAL domain
HV180_RS11115	COG1760	l-serine dehydratase
HV180_RS11145	COG1653	transport
HV180_RS11150	COG1175	transmembrane transport
HV180_RS11155	COG0395	ABC-type sugar transport system, permease component
HV180_RS11160	COG3842	ATPase activity
HV180_RS11170	COG0251	oxidation-reduction process
HV180_RS11175	COG1199	ATP-dependent helicase activity
HV180_RS11180	COG1214	PFAM Peptidase M22, glycoprotease
HV180_RS11185	COG3065	identical protein binding
HV180_RS11195	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV180_RS11205	COG2894	cell division
HV180_RS11220	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV180_RS11250	COG2719	SpoVR family
HV180_RS11270	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV180_RS11280	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HV180_RS11285	COG2211	Major facilitator Superfamily
HV180_RS11295	COG1472	Belongs to the glycosyl hydrolase 3 family
HV180_RS11300	COG2308	Evidence 4 Homologs of previously reported genes of
HV180_RS11325	COG2814	Major facilitator Superfamily
HV180_RS11345	COG0583	DNA-binding transcription factor activity
HV180_RS11350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HV180_RS11370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS11370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS11375	COG2814	Major facilitator Superfamily
HV180_RS11390	COG2068	MobA-Related Protein
HV180_RS11400	COG2233	PERMEase
HV180_RS11410	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV180_RS11415	COG0402	S-adenosylhomocysteine deaminase activity
HV180_RS11420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV180_RS11420	COG0493	'glutamate synthase
HV180_RS11425	COG3608	succinylglutamate desuccinylase aspartoacylase
HV180_RS11425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HV180_RS11430	COG0549	Belongs to the carbamate kinase family
HV180_RS11440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV180_RS11445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV180_RS11450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV180_RS11460	COG0012	GTP binding
HV180_RS11480	COG0659	secondary active sulfate transmembrane transporter activity
HV180_RS11510	COG2890	protein-(glutamine-N5) methyltransferase activity
HV180_RS11530	COG0387	Pfam Sodium calcium exchanger
HV180_RS11535	COG4572	Cation transport regulator
HV180_RS11540	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV180_RS11550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV180_RS11555	COG3707	response regulator
HV180_RS11560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV180_RS11570	COG1116	anion transmembrane transporter activity
HV180_RS11575	COG2146	nitrite reductase [NAD(P)H] activity
HV180_RS11575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV180_RS11580	COG0243	molybdopterin cofactor binding
HV180_RS11585	COG4932	domain protein
HV180_RS11590	COG2197	response regulator
HV180_RS11595	COG3850	Histidine kinase
HV180_RS11600	COG2223	nitrite transmembrane transporter activity
HV180_RS11605	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV180_RS11610	COG1140	nitrate reductase beta subunit
HV180_RS11615	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV180_RS11620	COG2181	nitrate reductase activity
HV180_RS11640	COG0788	formyltetrahydrofolate deformylase activity
HV180_RS11650	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV180_RS11655	COG0745	RESPONSE REGULATOR receiver
HV180_RS11660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV180_RS11680	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS11680	COG1454	alcohol dehydrogenase
HV180_RS11685	COG2095	MarC family integral membrane protein
HV180_RS11695	COG0601	transmembrane transport
HV180_RS11700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV180_RS11705	COG0444	Belongs to the ABC transporter superfamily
HV180_RS11715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV180_RS11735	COG1902	pentaerythritol trinitrate reductase activity
HV180_RS11740	COG2350	Protein conserved in bacteria
HV180_RS11745	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HV180_RS11750	COG3001	Fructosamine kinase
HV180_RS11760	COG1105	Belongs to the carbohydrate kinase PfkB family
HV180_RS11765	COG3137	Salt-induced outer membrane protein
HV180_RS11790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HV180_RS11810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV180_RS11810	COG0072	phenylalanine-tRNA ligase activity
HV180_RS11830	COG0386	Belongs to the glutathione peroxidase family
HV180_RS11840	COG0791	NLP P60 protein
HV180_RS11850	COG4256	Hemin uptake protein
HV180_RS11855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV180_RS11865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV180_RS11865	COG0574	Belongs to the PEP-utilizing enzyme family
HV180_RS11875	COG0628	permease
HV180_RS11880	COG0247	lactate metabolic process
HV180_RS11880	COG0277	FAD linked oxidase domain protein
HV180_RS11885	COG2050	protein possibly involved in aromatic compounds catabolism
HV180_RS11890	COG2261	transglycosylase associated protein
HV180_RS11905	COG0316	Belongs to the HesB IscA family
HV180_RS11910	COG0719	Fe-S assembly protein
HV180_RS11915	COG0396	ATPase activity
HV180_RS11920	COG0719	Fe-S assembly protein
HV180_RS11935	COG1376	ErfK ybiS ycfS ynhG family protein
HV180_RS11965	COG2271	Major facilitator Superfamily
HV180_RS11970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV180_RS11995	COG1414	Transcriptional regulator
HV180_RS12030	COG2814	Major facilitator Superfamily
HV180_RS12055	COG0583	DNA-binding transcription factor activity
HV180_RS12060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV180_RS12065	COG1960	acyl-CoA dehydrogenase activity
HV180_RS12080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV180_RS12085	COG1116	anion transmembrane transporter activity
HV180_RS12090	COG4774	siderophore transport
HV180_RS12095	COG1120	ATPase activity
HV180_RS12100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS12105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS12125	COG0765	amino acid transport
HV180_RS12130	COG1126	abc transporter atp-binding protein
HV180_RS12145	COG3383	formate dehydrogenase (NAD+) activity
HV180_RS12150	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV180_RS12155	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV180_RS12160	COG0672	)-iron permease
HV180_RS12175	COG1136	(ABC) transporter
HV180_RS12175	COG0577	efflux transmembrane transporter activity
HV180_RS12185	COG0577	efflux transmembrane transporter activity
HV180_RS12185	COG1136	(ABC) transporter
HV180_RS12200	COG1175	transmembrane transport
HV180_RS12205	COG3842	ATPase activity
HV180_RS12230	COG1278	Cold shock
HV180_RS12235	COG0626	cystathionine gamma-synthase activity
HV180_RS12240	COG1757	Na H antiporter
HV180_RS12270	COG4993	Dehydrogenase
HV180_RS12275	COG4608	Belongs to the ABC transporter superfamily
HV180_RS12280	COG0444	Belongs to the ABC transporter superfamily
HV180_RS12310	COG2011	ABC-type metal ion transport system permease component
HV180_RS12325	COG0346	lactoylglutathione lyase activity
HV180_RS12330	COG1349	DNA-binding transcription factor activity
HV180_RS12345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV180_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS12355	COG3111	PFAM Bacterial OB fold (BOF) protein
HV180_RS12365	COG4529	Protein conserved in bacteria
HV180_RS12380	COG0366	Alpha amylase catalytic
HV180_RS12385	COG1609	Transcriptional regulator
HV180_RS12395	COG2323	membrane
HV180_RS12400	COG1546	Belongs to the CinA family
HV180_RS12410	COG0366	Alpha amylase catalytic
HV180_RS12415	COG1294	oxidase, subunit
HV180_RS12420	COG1271	oxidase subunit
HV180_RS12425	COG3546	catalase activity
HV180_RS12430	COG3685	Protein conserved in bacteria
HV180_RS12435	COG3685	Protein conserved in bacteria
HV180_RS12440	COG3729	General stress protein
HV180_RS12465	COG0307	riboflavin synthase, alpha
HV180_RS12470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV180_RS12475	COG2814	Major facilitator Superfamily
HV180_RS12480	COG0583	DNA-binding transcription factor activity
HV180_RS12495	COG2814	Major facilitator Superfamily
HV180_RS12505	COG0791	NLP P60 protein
HV180_RS12510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV180_RS12520	COG0346	lactoylglutathione lyase activity
HV180_RS12525	COG1902	pentaerythritol trinitrate reductase activity
HV180_RS12530	COG1309	transcriptional regulator
HV180_RS12535	COG3313	Fe-S protein
HV180_RS12540	COG4989	oxidoreductase activity
HV180_RS12550	COG1289	transmembrane transporter activity
HV180_RS12555	COG1566	PFAM secretion protein HlyD family protein
HV180_RS12570	COG3706	GGDEF domain
HV180_RS12585	COG3895	Periplasmic Protein
HV180_RS12605	COG0625	glutathione transferase activity
HV180_RS12615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV180_RS12625	COG4659	FMN binding
HV180_RS12660	COG2723	6-phospho-beta-galactosidase activity
HV180_RS12670	COG0673	inositol 2-dehydrogenase activity
HV180_RS12685	COG0425	Belongs to the sulfur carrier protein TusA family
HV180_RS12690	COG2391	methyltransferase activity
HV180_RS12700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV180_RS12705	COG1263	PTS System
HV180_RS12705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS12710	COG1609	Transcriptional regulator
HV180_RS12715	COG5339	Protein conserved in bacteria
HV180_RS12720	COG1482	cell wall glycoprotein biosynthetic process
HV180_RS12725	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS12725	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS12740	COG2205	protein histidine kinase activity
HV180_RS12745	COG0745	RESPONSE REGULATOR receiver
HV180_RS12755	COG3136	membrane protein required for alginate biosynthesis
HV180_RS12765	COG0531	amino acid
HV180_RS12780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV180_RS12785	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV180_RS12795	COG0589	response to stress
HV180_RS12800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV180_RS12805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV180_RS12810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HV180_RS12815	COG1473	amidohydrolase
HV180_RS12825	COG0583	DNA-binding transcription factor activity
HV180_RS12830	COG2840	Smr protein MutS2
HV180_RS12835	COG1414	Transcriptional regulator
HV180_RS12845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV180_RS12850	COG0183	Belongs to the thiolase family
HV180_RS12860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV180_RS12865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV180_RS12890	COG4565	transcriptional regulatory protein
HV180_RS12895	COG3290	protein histidine kinase activity
HV180_RS12900	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV180_RS12915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV180_RS12925	COG0679	Auxin Efflux Carrier
HV180_RS12960	COG0628	permease
HV180_RS12980	COG3300	MHYT domain
HV180_RS12980	COG5001	Diguanylate cyclase
HV180_RS12985	COG3591	Belongs to the peptidase S1B family
HV180_RS13005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV180_RS13010	COG2814	Major facilitator Superfamily
HV180_RS13015	COG0583	DNA-binding transcription factor activity
HV180_RS13020	COG1940	carbohydrate kinase activity
HV180_RS13025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV180_RS13040	COG3302	dmso reductase anchor subunit
HV180_RS13045	COG0437	4 iron, 4 sulfur cluster binding
HV180_RS13065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV180_RS13080	COG4948	Mandelate Racemase Muconate Lactonizing
HV180_RS13095	COG1063	alcohol dehydrogenase
HV180_RS13100	COG0477	Major facilitator Superfamily
HV180_RS13105	COG0246	Mannitol dehydrogenase
HV180_RS13110	COG0589	response to stress
HV180_RS13115	COG1802	Transcriptional regulator
HV180_RS13120	COG4221	oxidoreductase activity
HV180_RS13125	COG0339	signal peptide processing
HV180_RS13170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV180_RS13185	COG2135	peptidase activity
HV180_RS13205	COG3122	Protein conserved in bacteria
HV180_RS13235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV180_RS13240	COG2223	nitrite transmembrane transporter activity
HV180_RS13260	COG2200	EAL domain
HV180_RS13295	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV180_RS13315	COG1129	ABC transporter
HV180_RS13330	COG2814	Major facilitator Superfamily
HV180_RS13390	COG0861	Integral membrane protein TerC family
HV180_RS13395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV180_RS13400	COG1454	alcohol dehydrogenase
HV180_RS13405	COG3395	kinase activity
HV180_RS13410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV180_RS13415	COG1349	DNA-binding transcription factor activity
HV180_RS13430	COG0583	DNA-binding transcription factor activity
HV180_RS13435	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS13450	COG2199	diguanylate cyclase activity
HV180_RS13495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS13500	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV180_RS13535	COG3121	Chaperone
HV180_RS13560	COG0477	Major facilitator Superfamily
HV180_RS13575	COG2011	ABC-type metal ion transport system permease component
HV180_RS13595	COG4628	conserved protein (DUF2132)
HV180_RS13610	COG1126	abc transporter atp-binding protein
HV180_RS13615	COG0765	amino acid transport
HV180_RS13620	COG0765	amino acid transport
HV180_RS13640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV180_RS13645	COG2207	Transcriptional regulator
HV180_RS13655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV180_RS13660	COG1446	asparaginase
HV180_RS13665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS13680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HV180_RS13685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV180_RS13690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS13700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV180_RS13710	COG3775	system Galactitol-specific IIC component
HV180_RS13715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV180_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS13725	COG1070	Carbohydrate kinase
HV180_RS13750	COG3188	usher protein
HV180_RS13780	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS13795	COG1609	Transcriptional regulator
HV180_RS13805	COG0693	protein deglycase activity
HV180_RS13820	COG0412	Dienelactone hydrolase
HV180_RS13835	COG0583	DNA-binding transcription factor activity
HV180_RS13860	COG2841	Protein conserved in bacteria
HV180_RS13885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS13900	COG4821	SIS domain
HV180_RS13905	COG2188	Transcriptional regulator
HV180_RS13935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV180_RS13985	COG3121	Chaperone
HV180_RS14000	COG3539	Fimbrial protein
HV180_RS14025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV180_RS14035	COG2271	Major facilitator Superfamily
HV180_RS14045	COG3716	PTS system mannose fructose sorbose family IID component
HV180_RS14055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS14055	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS14065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV180_RS14075	COG4771	TonB-dependent receptor
HV180_RS14080	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV180_RS14100	COG3433	isochorismatase activity
HV180_RS14100	COG2226	methyltransferase
HV180_RS14100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV180_RS14115	COG1132	(ABC) transporter
HV180_RS14120	COG2814	Major facilitator Superfamily
HV180_RS14150	COG0814	amino acid
HV180_RS14155	COG1760	l-serine dehydratase
HV180_RS14175	COG3384	dioxygenase
HV180_RS14180	COG0583	DNA-binding transcription factor activity
HV180_RS14185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HV180_RS14190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV180_RS14195	COG2828	Protein conserved in bacteria
HV180_RS14215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV180_RS14225	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS14235	COG0401	homolog of Blt101
HV180_RS14250	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV180_RS14255	COG2771	luxR family
HV180_RS14255	COG2200	EAL domain
HV180_RS14310	COG0673	inositol 2-dehydrogenase activity
HV180_RS14315	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HV180_RS14320	COG1116	anion transmembrane transporter activity
HV180_RS14325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV180_RS14330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV180_RS14335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV180_RS14340	COG0076	glutamate decarboxylase activity
HV180_RS14345	COG0300	oxidoreductase activity
HV180_RS14355	COG0519	Catalyzes the synthesis of GMP from XMP
HV180_RS14355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HV180_RS14415	COG2271	Major facilitator Superfamily
HV180_RS14430	COG0583	DNA-binding transcription factor activity
HV180_RS14445	COG0243	molybdopterin cofactor binding
HV180_RS14450	COG3781	membrane
HV180_RS14465	COG1764	response to oxidative stress
HV180_RS14475	COG0583	DNA-binding transcription factor activity
HV180_RS14495	COG0745	RESPONSE REGULATOR receiver
HV180_RS14500	COG0488	(ABC) transporter
HV180_RS14515	COG1064	alcohol dehydrogenase
HV180_RS14540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV180_RS14550	COG2814	Major facilitator Superfamily
HV180_RS14560	COG2864	formate dehydrogenase
HV180_RS14565	COG0437	4 iron, 4 sulfur cluster binding
HV180_RS14575	COG0697	spore germination
HV180_RS14590	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HV180_RS14600	COG3485	protocatechuate 3,4-dioxygenase
HV180_RS14605	COG4829	muconolactone delta-isomerase
HV180_RS14610	COG4948	Mandelate Racemase Muconate Lactonizing
HV180_RS14615	COG1414	Transcriptional regulator
HV180_RS14630	COG2223	nitrite transmembrane transporter activity
HV180_RS14635	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV180_RS14640	COG1140	nitrate reductase beta subunit
HV180_RS14645	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV180_RS14650	COG2181	nitrate reductase activity
HV180_RS14665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV180_RS14670	COG1178	ABC-type Fe3 transport system permease component
HV180_RS14675	COG1840	ABC-type Fe3 transport system, periplasmic component
HV180_RS14680	COG3842	ATPase activity
HV180_RS14685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV180_RS14695	COG2382	esterase
HV180_RS14745	COG4977	sequence-specific DNA binding
HV180_RS14755	COG2211	Major facilitator Superfamily
HV180_RS14775	COG0625	glutathione transferase activity
HV180_RS14780	COG1609	Transcriptional regulator
HV180_RS14790	COG2271	Major facilitator Superfamily
HV180_RS14800	COG1126	abc transporter atp-binding protein
HV180_RS14820	COG1473	amidohydrolase
HV180_RS14825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV180_RS14850	COG4772	TonB-dependent receptor
HV180_RS14855	COG3691	Protein conserved in bacteria
HV180_RS14865	COG2130	NADP-dependent
HV180_RS14880	COG1247	-acetyltransferase
HV180_RS14885	COG3238	Protein conserved in bacteria
HV180_RS14895	COG0747	negative chemotaxis
HV180_RS14900	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS14905	COG4677	pectinesterase activity
HV180_RS14935	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS14940	COG1177	transmembrane transport
HV180_RS14945	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV180_RS14950	COG3842	ATPase activity
HV180_RS14955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV180_RS14960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV180_RS14965	COG1271	oxidase subunit
HV180_RS14970	COG1294	oxidase, subunit
HV180_RS14985	COG0826	peptidase U32
HV180_RS14990	COG1396	sequence-specific DNA binding
HV180_RS14995	COG3135	benzoate transporter
HV180_RS15005	COG0697	spore germination
HV180_RS15015	COG0747	negative chemotaxis
HV180_RS15020	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV180_RS15025	COG0500	methyltransferase
HV180_RS15030	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV180_RS15035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV180_RS15040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV180_RS15050	COG1335	isochorismatase
HV180_RS15055	COG2272	Belongs to the type-B carboxylesterase lipase family
HV180_RS15060	COG5383	Protein conserved in bacteria
HV180_RS15065	COG3485	protocatechuate 3,4-dioxygenase
HV180_RS15075	COG0583	DNA-binding transcription factor activity
HV180_RS15110	COG3038	cytochrome b561
HV180_RS15130	COG3706	GGDEF domain
HV180_RS15135	COG0583	DNA-binding transcription factor activity
HV180_RS15145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV180_RS15150	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS15155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV180_RS15160	COG0477	Major facilitator Superfamily
HV180_RS15165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV180_RS15185	COG1538	Outer membrane efflux protein
HV180_RS15190	COG4122	O-methyltransferase activity
HV180_RS15195	COG1643	Atp-dependent helicase
HV180_RS15210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV180_RS15215	COG3327	negative regulation of DNA-templated transcription, initiation
HV180_RS15220	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV180_RS15225	COG0183	Belongs to the thiolase family
HV180_RS15230	COG2050	protein possibly involved in aromatic compounds catabolism
HV180_RS15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV180_RS15240	COG1024	Enoyl-CoA hydratase
HV180_RS15245	COG1024	Enoyl-CoA hydratase
HV180_RS15250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV180_RS15255	COG2151	metal-sulfur cluster biosynthetic enzyme
HV180_RS15260	COG3396	Phenylacetate-CoA oxygenase
HV180_RS15265	COG3460	Phenylacetate-CoA oxygenase
HV180_RS15270	COG3396	Phenylacetate-CoA oxygenase
HV180_RS15275	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS15275	COG2030	dehydratase
HV180_RS15295	COG0191	fructose-bisphosphate aldolase activity
HV180_RS15305	COG3775	system Galactitol-specific IIC component
HV180_RS15310	COG3414	Phosphotransferase system galactitol-specific IIB component
HV180_RS15320	COG2188	Transcriptional regulator
HV180_RS15325	COG0583	DNA-binding transcription factor activity
HV180_RS15330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV180_RS15335	COG3069	C4-dicarboxylate transmembrane transporter activity
HV180_RS15340	COG1349	DNA-binding transcription factor activity
HV180_RS15345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS15350	COG2084	Dehydrogenase
HV180_RS15355	COG3684	Belongs to the aldolase LacD family
HV180_RS15360	COG1063	alcohol dehydrogenase
HV180_RS15370	COG0477	Major facilitator Superfamily
HV180_RS15400	COG0277	FAD linked oxidase domain protein
HV180_RS15405	COG1070	Carbohydrate kinase
HV180_RS15415	COG2814	Major facilitator Superfamily
HV180_RS15420	COG1869	D-ribose catabolic process
HV180_RS15425	COG2814	Major facilitator Superfamily
HV180_RS15435	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV180_RS15455	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS15460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS15475	COG4977	sequence-specific DNA binding
HV180_RS15500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS15505	COG2207	Transcriptional regulator
HV180_RS15505	COG3708	Transcriptional regulator
HV180_RS15515	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS15520	COG2207	Transcriptional regulator
HV180_RS15525	COG3784	Protein of unknown function (DUF1318)
HV180_RS15535	COG2911	Protein conserved in bacteria
HV180_RS15540	COG0586	Pfam SNARE associated Golgi protein
HV180_RS15545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV180_RS15550	COG3187	Heat shock protein
HV180_RS15555	COG3042	response to heat
HV180_RS15590	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV180_RS15590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV180_RS15590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV180_RS15590	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV180_RS15595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV180_RS15605	COG0589	response to stress
HV180_RS15625	COG0513	Belongs to the DEAD box helicase family
HV180_RS15635	COG2197	response regulator
HV180_RS15640	COG3539	Fimbrial protein
HV180_RS15655	COG3121	Chaperone
HV180_RS15660	COG3539	Fimbrial protein
HV180_RS15670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV180_RS15675	COG1349	DNA-binding transcription factor activity
HV180_RS15680	COG0673	inositol 2-dehydrogenase activity
HV180_RS15690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV180_RS15710	COG3477	response to acidic pH
HV180_RS15740	COG0583	DNA-binding transcription factor activity
HV180_RS15770	COG0789	Transcriptional regulator
HV180_RS15780	COG0300	oxidoreductase activity
HV180_RS15795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV180_RS15805	COG3272	Protein of unknown function (DUF1722)
HV180_RS15815	COG2211	Major facilitator Superfamily
HV180_RS15820	COG3507	Belongs to the glycosyl hydrolase 43 family
HV180_RS15920	COG2885	chlorophyll binding
HV180_RS15935	COG4166	transmembrane transport
HV180_RS15940	COG2866	Carboxypeptidase
HV180_RS15945	COG4948	Mandelate Racemase Muconate Lactonizing
HV180_RS15950	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV180_RS15955	COG3180	Ammonia monooxygenase
HV180_RS15970	COG3106	COG3106 Predicted ATPase
HV180_RS15975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV180_RS15985	COG1983	PspC domain protein
HV180_RS15995	COG1842	Phage shock protein A
HV180_RS16000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV180_RS16010	COG1473	amidohydrolase
HV180_RS16030	COG4168	peptide transport system, permease
HV180_RS16065	COG4171	peptide transport system, permease
HV180_RS16075	COG4172	Belongs to the ABC transporter superfamily
HV180_RS16085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV180_RS16090	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV180_RS16090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV180_RS16105	COG1349	DNA-binding transcription factor activity
HV180_RS16115	COG0023	Translation Initiation Factor
HV180_RS16125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV180_RS16130	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV180_RS16135	COG0671	phosphoesterase, PA-phosphatase related
HV180_RS16145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV180_RS16170	COG0616	signal peptide processing
HV180_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS16180	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV180_RS16185	COG2207	Transcriptional regulator
HV180_RS16190	COG1472	Belongs to the glycosyl hydrolase 3 family
HV180_RS16195	COG2211	Major facilitator Superfamily
HV180_RS16200	COG1187	pseudouridine synthase activity
HV180_RS16205	COG0009	L-threonylcarbamoyladenylate synthase
HV180_RS16215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HV180_RS16220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV180_RS16220	COG0512	Glutamine amidotransferase of anthranilate synthase
HV180_RS16225	COG0135	phosphoribosylanthranilate isomerase activity
HV180_RS16225	COG0134	indole-3-glycerol-phosphate synthase activity
HV180_RS16240	COG2207	Transcriptional regulator
HV180_RS16240	COG3708	Transcriptional regulator
HV180_RS16255	COG3047	cAMP biosynthetic process
HV180_RS16270	COG0038	chloride channel
HV180_RS16290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV180_RS16295	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS16300	COG1988	membrane-bound metal-dependent
HV180_RS16315	COG0753	catalase activity
HV180_RS16325	COG1486	melibiose metabolic process
HV180_RS16330	COG2169	Transcriptional regulator
HV180_RS16330	COG1917	Cupin 2, conserved barrel domain protein
HV180_RS16335	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV180_RS16340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS16345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS16350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV180_RS16360	COG0322	excinuclease ABC activity
HV180_RS16370	COG1704	LemA family
HV180_RS16375	COG3678	ATP-independent chaperone mediated protein folding
HV180_RS16385	COG3724	N-succinylarginine dihydrolase activity
HV180_RS16405	COG0708	Exodeoxyribonuclease III
HV180_RS16410	COG0398	Pfam SNARE associated Golgi protein
HV180_RS16415	COG0398	Pfam SNARE associated Golgi protein
HV180_RS16420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV180_RS16425	COG4134	Bacterial extracellular solute-binding protein
HV180_RS16430	COG4135	transport system, permease component
HV180_RS16435	COG4136	ATPase activity
HV180_RS16440	COG2897	thiosulfate sulfurtransferase activity
HV180_RS16450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV180_RS16455	COG0494	nUDIX hydrolase
HV180_RS16460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV180_RS16465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV180_RS16470	COG0709	Synthesizes selenophosphate from selenide and ATP
HV180_RS16480	COG0778	Nitroreductase
HV180_RS16485	COG0616	signal peptide processing
HV180_RS16490	COG0252	asparaginase activity
HV180_RS16495	COG1335	isochorismatase
HV180_RS16500	COG2814	Major facilitator Superfamily
HV180_RS16505	COG1349	DNA-binding transcription factor activity
HV180_RS16510	COG0667	Aldo Keto reductase
HV180_RS16515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS16520	COG0191	fructose-bisphosphate aldolase activity
HV180_RS16525	COG1063	alcohol dehydrogenase
HV180_RS16530	COG2271	Major facilitator Superfamily
HV180_RS16535	COG1063	alcohol dehydrogenase
HV180_RS16550	COG3139	Protein of unknown function (DUF1315)
HV180_RS16570	COG0656	L-ascorbic acid biosynthetic process
HV180_RS16575	COG3713	MltA-interacting MipA family protein
HV180_RS16580	COG2766	serine protein kinase
HV180_RS16590	COG0859	PFAM glycosyl transferase family 9
HV180_RS16595	COG2199	diguanylate cyclase activity
HV180_RS16600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV180_RS16610	COG2207	Transcriptional regulator
HV180_RS16615	COG2807	transmembrane transport
HV180_RS16620	COG0504	CTP synthase activity
HV180_RS16625	COG1683	Conserved Protein
HV180_RS16630	COG3189	MarR family transcriptional regulator
HV180_RS16635	COG3042	response to heat
HV180_RS16780	COG4695	Portal protein
HV180_RS16800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV180_RS16840	COG4974	Belongs to the 'phage' integrase family
HV180_RS16845	COG2203	Gaf domain
HV180_RS16845	COG2199	diguanylate cyclase activity
HV180_RS16865	COG3182	Iron-regulated membrane protein
HV180_RS16875	COG1560	Kdo2-lipid A biosynthetic process
HV180_RS16880	COG2226	methyltransferase
HV180_RS16885	COG1595	DNA-templated transcription, initiation
HV180_RS16890	COG3712	iron ion homeostasis
HV180_RS16895	COG4772	TonB-dependent receptor
HV180_RS16900	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV180_RS16915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HV180_RS16920	COG3706	GGDEF domain
HV180_RS16930	COG0538	isocitrate dehydrogenase activity
HV180_RS16935	COG1187	pseudouridine synthase activity
HV180_RS16955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV180_RS16960	COG2814	Major facilitator Superfamily
HV180_RS16970	COG0745	RESPONSE REGULATOR receiver
HV180_RS16975	COG2205	protein histidine kinase activity
HV180_RS16980	COG2850	peptidyl-arginine hydroxylation
HV180_RS17000	COG1177	transmembrane transport
HV180_RS17015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV180_RS17020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV180_RS17025	COG0698	ribose 5-phosphate isomerase
HV180_RS17040	COG3395	kinase activity
HV180_RS17055	COG2390	Transcriptional regulator
HV180_RS17065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV180_RS17075	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV180_RS17080	COG1136	(ABC) transporter
HV180_RS17085	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV180_RS17090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV180_RS17095	COG1388	LysM domain
HV180_RS17095	COG1376	ErfK ybiS ycfS ynhG family protein
HV180_RS17105	COG1309	transcriptional regulator
HV180_RS17115	COG3134	Outer membrane lipoprotein
HV180_RS17120	COG1252	NADH dehydrogenase
HV180_RS17145	COG5633	Lipoprotein
HV180_RS17150	COG0537	adenosine 5'-monophosphoramidase activity
HV180_RS17155	COG4773	Receptor
HV180_RS17165	COG0084	hydrolase, TatD family'
HV180_RS17170	COG0470	DNA polymerase III
HV180_RS17180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV180_RS17185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV180_RS17220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV180_RS17235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV180_RS17255	COG1399	metal-binding, possibly nucleic acid-binding protein
HV180_RS17275	COG1530	ribonuclease E activity
HV180_RS17280	COG0583	DNA-binding transcription factor activity
HV180_RS17285	COG2814	Major facilitator Superfamily
HV180_RS17295	COG0673	inositol 2-dehydrogenase activity
HV180_RS17305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV180_RS17315	COG2999	glutathione oxidoreductase activity
HV180_RS17355	COG1560	Kdo2-lipid A biosynthetic process
HV180_RS17370	COG5645	(Lipo)protein
HV180_RS17410	COG3381	protein complex oligomerization
HV180_RS17430	COG0583	DNA-binding transcription factor activity
HV180_RS17440	COG1335	isochorismatase
HV180_RS17460	COG1702	phosphate starvation-inducible protein PhoH
HV180_RS17480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV180_RS17490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV180_RS17505	COG1309	transcriptional regulator
HV180_RS17540	COG2233	PERMEase
HV180_RS17545	COG3729	General stress protein
HV180_RS17575	COG0531	amino acid
HV180_RS17580	COG0174	glutamine synthetase
HV180_RS17585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV180_RS17590	COG1396	sequence-specific DNA binding
HV180_RS17590	COG1917	Cupin 2, conserved barrel domain protein
HV180_RS17595	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS17600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV180_RS17605	COG0583	DNA-binding transcription factor activity
HV180_RS17610	COG0473	3-isopropylmalate dehydrogenase activity
HV180_RS17615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS17615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS17615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV180_RS17620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS17625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS17630	COG1882	Formate acetyltransferase
HV180_RS17635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV180_RS17640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV180_RS17650	COG2207	Transcriptional regulator
HV180_RS17655	COG3706	GGDEF domain
HV180_RS17685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV180_RS17700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HV180_RS17765	COG1953	Uracil, thiamine, allantoin
HV180_RS17770	COG0402	S-adenosylhomocysteine deaminase activity
HV180_RS17775	COG2351	hydroxyisourate hydrolase activity
HV180_RS17785	COG2233	PERMEase
HV180_RS17790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV180_RS17835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV180_RS17845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV180_RS17855	COG1652	LysM domain
HV180_RS17860	COG1278	Cold shock
HV180_RS17865	COG1278	Cold shock
HV180_RS17875	COG0436	Aminotransferase
HV180_RS17880	COG1757	Na H antiporter
HV180_RS17885	COG1609	Transcriptional regulator
HV180_RS17890	COG3711	transcriptional antiterminator
HV180_RS17895	COG3711	transcriptional antiterminator
HV180_RS17895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS17920	COG0670	Belongs to the BI1 family
HV180_RS17925	COG2920	part of a sulfur-relay system
HV180_RS17935	COG2207	Transcriptional regulator
HV180_RS17940	COG1881	PFAM PEBP family protein
HV180_RS17960	COG0438	transferase activity, transferring glycosyl groups
HV180_RS17965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS17970	COG2274	protein secretion by the type I secretion system
HV180_RS18005	COG1832	CoA-binding protein
HV180_RS18015	COG0210	DNA helicase
HV180_RS18020	COG3304	Inner membrane component domain
HV180_RS18025	COG1289	transmembrane transporter activity
HV180_RS18030	COG3070	regulator of competence-specific genes
HV180_RS18050	COG1067	ATP-dependent peptidase activity
HV180_RS18060	COG3130	regulation of translation
HV180_RS18065	COG3009	Protein conserved in bacteria
HV180_RS18070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV180_RS18070	COG3008	intermembrane lipid transfer
HV180_RS18075	COG2995	paraquat-inducible protein a
HV180_RS18080	COG0488	(ABC) transporter
HV180_RS18090	COG3217	Mosc domain protein beta barrel domain protein
HV180_RS18090	COG0633	Ferredoxin
HV180_RS18105	COG0431	NADPH-dependent FMN reductase
HV180_RS18110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV180_RS18120	COG0308	aminopeptidase N
HV180_RS18125	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HV180_RS18135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV180_RS18140	COG1448	Aminotransferase
HV180_RS18145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV180_RS18150	COG3108	Peptidase M15
HV180_RS18155	COG2989	Protein conserved in bacteria
HV180_RS18165	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV180_RS18175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV180_RS18180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV180_RS18185	COG3173	Aminoglycoside phosphotransferase
HV180_RS18200	COG3214	Protein conserved in bacteria
HV180_RS18210	COG1132	(ABC) transporter
HV180_RS18215	COG0658	competence protein
HV180_RS18215	COG2333	competence protein COMEC
HV180_RS18225	COG0539	negative regulation of cytoplasmic translation
HV180_RS18235	COG0501	Belongs to the peptidase M48B family
HV180_RS18250	COG2323	membrane
HV180_RS18255	COG1944	ATP diphosphatase activity
HV180_RS18260	COG2116	formate transmembrane transporter activity
HV180_RS18265	COG1882	Formate acetyltransferase
HV180_RS18270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV180_RS18275	COG1737	Transcriptional regulator
HV180_RS18290	COG3959	Transketolase, thiamine diphosphate binding domain
HV180_RS18295	COG3958	Transketolase
HV180_RS18300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS18305	COG0477	Major facilitator Superfamily
HV180_RS18320	COG0437	4 iron, 4 sulfur cluster binding
HV180_RS18325	COG0243	molybdopterin cofactor binding
HV180_RS18335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV180_RS18345	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV180_RS18345	COG1674	ftsk spoiiie
HV180_RS18355	COG0492	ferredoxin-NADP+ reductase activity
HV180_RS18360	COG4988	ABC transporter
HV180_RS18365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV180_RS18375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV180_RS18385	COG0542	response to heat
HV180_RS18395	COG1278	Cold shock
HV180_RS18405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS18410	COG3593	DNA synthesis involved in DNA repair
HV180_RS18415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV180_RS18420	COG2431	L-lysine efflux transmembrane transporter activity
HV180_RS18430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV180_RS18440	COG0028	Belongs to the TPP enzyme family
HV180_RS18445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV180_RS18450	COG0702	epimerase
HV180_RS18455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV180_RS18460	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV180_RS18465	COG0393	Putative heavy-metal-binding
HV180_RS18475	COG1126	abc transporter atp-binding protein
HV180_RS18480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS18485	COG4215	(ABC) transporter
HV180_RS18490	COG4160	amino acid transport
HV180_RS18495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS18500	COG5002	protein histidine kinase activity
HV180_RS18505	COG0745	RESPONSE REGULATOR receiver
HV180_RS18520	COG1177	transmembrane transport
HV180_RS18525	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV180_RS18530	COG3842	ATPase activity
HV180_RS18535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV180_RS18550	COG0778	Nitroreductase
HV180_RS18575	COG3226	Transcriptional regulator
HV180_RS18580	COG0738	Major facilitator superfamily
HV180_RS18585	COG0561	phosphatase activity
HV180_RS18590	COG2814	Major facilitator Superfamily
HV180_RS18595	COG0671	phosphoesterase, PA-phosphatase related
HV180_RS18600	COG1349	DNA-binding transcription factor activity
HV180_RS18605	COG1686	Belongs to the peptidase S11 family
HV180_RS18710	COG0740	serine-type endopeptidase activity
HV180_RS18715	COG4695	Portal protein
HV180_RS18720	COG4626	Terminase
HV180_RS18720	COG1802	Transcriptional regulator
HV180_RS18840	COG1846	Transcriptional regulator
HV180_RS18890	COG0582	viral genome integration into host DNA
HV180_RS18895	COG0625	glutathione transferase activity
HV180_RS18900	COG2133	pyrroloquinoline quinone binding
HV180_RS18910	COG2223	nitrite transmembrane transporter activity
HV180_RS18935	COG0747	negative chemotaxis
HV180_RS18945	COG1446	asparaginase
HV180_RS18950	COG0303	'Molybdopterin
HV180_RS18955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV180_RS18960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV180_RS18965	COG1882	Formate acetyltransferase
HV180_RS18970	COG0561	phosphatase activity
HV180_RS18980	COG1609	Transcriptional regulator
HV180_RS18985	COG2271	Major facilitator Superfamily
HV180_RS18995	COG0488	(ABC) transporter
HV180_RS19005	COG1376	ErfK ybiS ycfS ynhG family protein
HV180_RS19010	COG2188	Transcriptional regulator
HV180_RS19015	COG2723	6-phospho-beta-galactosidase activity
HV180_RS19020	COG0667	Aldo Keto reductase
HV180_RS19025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV180_RS19040	COG2194	sulfuric ester hydrolase activity
HV180_RS19045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV180_RS19060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS19065	COG0765	amino acid transport
HV180_RS19070	COG1126	abc transporter atp-binding protein
HV180_RS19075	COG0668	transmembrane transport
HV180_RS19085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV180_RS19090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV180_RS19100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV180_RS19120	COG0513	Belongs to the DEAD box helicase family
HV180_RS19125	COG3958	Transketolase
HV180_RS19130	COG3959	Transketolase, thiamine diphosphate binding domain
HV180_RS19135	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS19140	COG2271	Major facilitator Superfamily
HV180_RS19145	COG0583	DNA-binding transcription factor activity
HV180_RS19150	COG1309	transcriptional regulator
HV180_RS19155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS19160	COG1131	(ABC) transporter
HV180_RS19165	COG0842	Transport permease protein
HV180_RS19170	COG0842	Transport permease protein
HV180_RS19180	COG3568	Endonuclease Exonuclease Phosphatase
HV180_RS19185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV180_RS19190	COG0392	lysyltransferase activity
HV180_RS19195	COG0670	Belongs to the BI1 family
HV180_RS19200	COG0314	molybdopterin synthase activity
HV180_RS19205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV180_RS19215	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV180_RS19235	COG0745	RESPONSE REGULATOR receiver
HV180_RS19260	COG2226	methyltransferase
HV180_RS19275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV180_RS19280	COG1881	PFAM PEBP family protein
HV180_RS19325	COG4677	pectinesterase activity
HV180_RS19340	COG0789	Transcriptional regulator
HV180_RS19345	COG2200	EAL domain
HV180_RS19365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV180_RS19380	COG0561	phosphatase activity
HV180_RS19390	COG4149	molybdate abc transporter
HV180_RS19395	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV180_RS19405	COG3585	molybdate ion transport
HV180_RS19405	COG2005	Transcriptional regulator
HV180_RS19410	COG1119	ATPase activity
HV180_RS19415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV180_RS19420	COG1085	galactose-1-phosphate uridylyltransferase
HV180_RS19430	COG2017	converts alpha-aldose to the beta-anomer
HV180_RS19440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV180_RS19460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HV180_RS19490	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV180_RS19495	COG2885	chlorophyll binding
HV180_RS19505	COG3064	Membrane
HV180_RS19510	COG0848	biopolymer transport protein
HV180_RS19515	COG0811	peptide transport
HV180_RS19520	COG0824	Thioesterase
HV180_RS19525	COG3790	cyd operon protein YbgE
HV180_RS19530	COG4890	Cyd operon protein YbgT
HV180_RS19535	COG1294	oxidase, subunit
HV180_RS19540	COG1271	oxidase subunit
HV180_RS19545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV180_RS19555	COG4865	methylaspartate mutase activity
HV180_RS19560	COG3799	methylaspartate ammonia-lyase activity
HV180_RS19575	COG1301	dicarboxylic acid transport
HV180_RS19585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS19585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV180_RS19590	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV180_RS19595	COG0583	DNA-binding transcription factor activity
HV180_RS19605	COG3395	kinase activity
HV180_RS19610	COG0235	Class ii aldolase
HV180_RS19615	COG1349	DNA-binding transcription factor activity
HV180_RS19620	COG3622	Belongs to the hyi family
HV180_RS19625	COG3246	L-lysine catabolic process to acetate
HV180_RS19645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV180_RS19655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV180_RS19660	COG0567	Dehydrogenase, E1 component
HV180_RS19665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV180_RS19670	COG1053	succinate dehydrogenase
HV180_RS19675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV180_RS19685	COG0372	Belongs to the citrate synthase family
HV180_RS19715	COG1984	allophanate hydrolase subunit 2
HV180_RS19720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV180_RS19725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV180_RS19735	COG0415	Belongs to the DNA photolyase family
HV180_RS19765	COG2205	protein histidine kinase activity
HV180_RS19770	COG0745	RESPONSE REGULATOR receiver
HV180_RS19780	COG3623	hexulose-6-phosphate isomerase
HV180_RS19785	COG1070	Carbohydrate kinase
HV180_RS19790	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS19795	COG1129	ABC transporter
HV180_RS19800	COG1879	ABC-type sugar transport system periplasmic component
HV180_RS19805	COG1063	alcohol dehydrogenase
HV180_RS19810	COG1349	DNA-binding transcription factor activity
HV180_RS19820	COG0033	Phosphoglucomutase
HV180_RS19825	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV180_RS19830	COG0596	Alpha beta hydrolase
HV180_RS19845	COG0735	belongs to the Fur family
HV180_RS19850	COG0583	DNA-binding transcription factor activity
HV180_RS19855	COG1053	succinate dehydrogenase
HV180_RS19895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV180_RS19900	COG1846	Transcriptional regulator
HV180_RS19900	COG1940	carbohydrate kinase activity
HV180_RS19905	COG0647	UMP catabolic process
HV180_RS19910	COG0367	asparagine synthase
HV180_RS19950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV180_RS19960	COG1702	phosphate starvation-inducible protein PhoH
HV180_RS19970	COG4535	Mg2 and Co2 transporter CorC
HV180_RS19985	COG0765	amino acid transport
HV180_RS19990	COG0765	amino acid transport
HV180_RS19995	COG1126	abc transporter atp-binding protein
HV180_RS20000	COG2831	hemolysin activation secretion protein
HV180_RS20005	COG3210	domain, Protein
HV180_RS20010	COG2888	peptidyl-tyrosine sulfation
HV180_RS20025	COG1466	dna polymerase III delta subunit
HV180_RS20035	COG0406	alpha-ribazole phosphatase activity
HV180_RS20040	COG0799	negative regulation of ribosome biogenesis
HV180_RS20050	COG0768	penicillin binding
HV180_RS20055	COG0772	Belongs to the SEDS family
HV180_RS20060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV180_RS20065	COG1686	Belongs to the peptidase S11 family
HV180_RS20080	COG0583	DNA-binding transcription factor activity
HV180_RS20090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV180_RS20095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV180_RS20115	COG3069	C4-dicarboxylate transmembrane transporter activity
HV180_RS20120	COG3719	Belongs to the RNase T2 family
HV180_RS20125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV180_RS20135	COG3634	alkyl hydroperoxide reductase activity
HV180_RS20145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV180_RS20150	COG0583	DNA-binding transcription factor activity
HV180_RS20155	COG3969	phosphoadenosine phosphosulfate
HV180_RS20160	COG1475	DNA binding
HV180_RS20165	COG0436	Aminotransferase
HV180_RS20170	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HV180_RS20175	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HV180_RS20190	COG1129	ABC transporter
HV180_RS20195	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS20200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS20210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV180_RS20225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV180_RS20235	COG0402	S-adenosylhomocysteine deaminase activity
HV180_RS20245	COG0483	inositol monophosphate 1-phosphatase activity
HV180_RS20250	COG2271	Major facilitator Superfamily
HV180_RS20280	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS20285	COG1129	ABC transporter
HV180_RS20290	COG0371	Dehydrogenase
HV180_RS20300	COG2879	small protein
HV180_RS20305	COG1966	Carbon starvation protein
HV180_RS20315	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS20320	COG3433	isochorismatase activity
HV180_RS20320	COG1535	isochorismatase
HV180_RS20325	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV180_RS20330	COG1169	isochorismate synthase
HV180_RS20335	COG4592	Periplasmic binding protein
HV180_RS20350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS20355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS20360	COG1120	ATPase activity
HV180_RS20365	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV180_RS20365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV180_RS20370	COG3251	PFAM MbtH domain protein
HV180_RS20375	COG2382	esterase
HV180_RS20380	COG4771	TonB-dependent receptor
HV180_RS20385	COG2977	Belongs to the P-Pant transferase superfamily
HV180_RS20390	COG3958	Transketolase
HV180_RS20395	COG3959	Transketolase, thiamine diphosphate binding domain
HV180_RS20400	COG2390	Transcriptional regulator
HV180_RS20405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV180_RS20410	COG1879	ABC-type sugar transport system periplasmic component
HV180_RS20420	COG1129	ABC transporter
HV180_RS20425	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS20435	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS20440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV180_RS20450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV180_RS20475	COG0747	negative chemotaxis
HV180_RS20480	COG0601	transmembrane transport
HV180_RS20490	COG0444	Belongs to the ABC transporter superfamily
HV180_RS20495	COG4172	Belongs to the ABC transporter superfamily
HV180_RS20505	COG4221	oxidoreductase activity
HV180_RS20515	COG0765	amino acid transport
HV180_RS20525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV180_RS20540	COG0697	spore germination
HV180_RS20550	COG0154	amidase activity
HV180_RS20555	COG0444	Belongs to the ABC transporter superfamily
HV180_RS20560	COG4608	Belongs to the ABC transporter superfamily
HV180_RS20565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV180_RS20575	COG4166	transmembrane transport
HV180_RS20585	COG3698	Phosphodiester glycosidase
HV180_RS20615	COG4774	siderophore transport
HV180_RS20635	COG2315	Protein conserved in bacteria
HV180_RS20640	COG0778	Nitroreductase
HV180_RS20650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS20660	COG3716	PTS system mannose fructose sorbose family IID component
HV180_RS20670	COG2222	sugar isomerase
HV180_RS20675	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV180_RS20675	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HV180_RS20690	COG0477	Major facilitator Superfamily
HV180_RS20695	COG0668	transmembrane transport
HV180_RS20725	COG3188	usher protein
HV180_RS20740	COG2771	luxR family
HV180_RS20745	COG0583	DNA-binding transcription factor activity
HV180_RS20750	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS20770	COG2211	Major facilitator Superfamily
HV180_RS20775	COG1113	amino acid transport
HV180_RS20790	COG0667	Aldo Keto reductase
HV180_RS20795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS20800	COG1473	amidohydrolase
HV180_RS20805	COG3539	Fimbrial protein
HV180_RS20810	COG3121	Chaperone
HV180_RS20815	COG3188	usher protein
HV180_RS20825	COG3121	Chaperone
HV180_RS20865	COG3711	transcriptional antiterminator
HV180_RS20870	COG2723	6-phospho-beta-galactosidase activity
HV180_RS20875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS20875	COG1263	PTS System
HV180_RS20875	COG2190	(PTS) system
HV180_RS20880	COG0583	DNA-binding transcription factor activity
HV180_RS20920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS20925	COG1129	ABC transporter
HV180_RS20940	COG0673	inositol 2-dehydrogenase activity
HV180_RS20965	COG3104	oligopeptide transport
HV180_RS20975	COG0531	amino acid
HV180_RS20980	COG3710	Transcriptional regulator
HV180_RS20995	COG1737	Transcriptional regulator
HV180_RS21000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS21005	COG1129	ABC transporter
HV180_RS21010	COG1879	ABC-type sugar transport system periplasmic component
HV180_RS21025	COG0583	DNA-binding transcription factor activity
HV180_RS21035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV180_RS21060	COG1285	pathogenesis
HV180_RS21065	COG2211	Major facilitator Superfamily
HV180_RS21100	COG2501	S4 domain
HV180_RS21110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV180_RS21125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV180_RS21130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV180_RS21135	COG0549	Belongs to the carbamate kinase family
HV180_RS21145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV180_RS21150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV180_RS21170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV180_RS21175	COG3257	ureidoglycine aminohydrolase activity
HV180_RS21180	COG1929	Belongs to the glycerate kinase type-1 family
HV180_RS21185	COG2233	PERMEase
HV180_RS21195	COG1953	Uracil, thiamine, allantoin
HV180_RS21205	COG2084	Dehydrogenase
HV180_RS21215	COG3622	Belongs to the hyi family
HV180_RS21220	COG3960	tartronate-semialdehyde synthase activity
HV180_RS21255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV180_RS21260	COG4181	ATPase activity
HV180_RS21265	COG2755	lipolytic protein G-D-S-L family
HV180_RS21270	COG0300	oxidoreductase activity
HV180_RS21275	COG3118	belongs to the thioredoxin family
HV180_RS21280	COG0390	transport system, permease component
HV180_RS21285	COG4619	ABC transporter
HV180_RS21290	COG0330	HflC and HflK could
HV180_RS21295	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV180_RS21310	COG3735	TraB family
HV180_RS21315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV180_RS21325	COG2223	nitrite transmembrane transporter activity
HV180_RS21330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV180_RS21330	COG4651	solute:proton antiporter activity
HV180_RS21335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS21365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HV180_RS21375	COG2832	Protein of unknown function (DUF454)
HV180_RS21380	COG3923	Primosomal replication protein n
HV180_RS21395	COG3264	Mechanosensitive ion channel
HV180_RS21395	COG1196	nuclear chromosome segregation
HV180_RS21400	COG1309	transcriptional regulator
HV180_RS21405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS21410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV180_RS21425	COG0110	maltose O-acetyltransferase activity
HV180_RS21445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HV180_RS21465	COG1263	PTS System
HV180_RS21465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS21470	COG1874	Beta-galactosidase
HV180_RS21475	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HV180_RS21480	COG3833	ABC-type maltose transport systems, permease component
HV180_RS21485	COG1175	transmembrane transport
HV180_RS21490	COG2182	Extracellular solute-binding protein
HV180_RS21500	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV180_RS21515	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV180_RS21520	COG2364	Membrane
HV180_RS21545	COG3695	enzyme binding
HV180_RS21550	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV180_RS21555	COG1946	Acyl-CoA thioesterase
HV180_RS21560	COG0004	ammonium transporteR
HV180_RS21565	COG0347	Belongs to the P(II) protein family
HV180_RS21570	COG1132	(ABC) transporter
HV180_RS21575	COG1132	(ABC) transporter
HV180_RS21580	COG1522	sequence-specific DNA binding
HV180_RS21595	COG4533	DNA binding
HV180_RS21605	COG0824	Thioesterase
HV180_RS21610	COG1555	photosystem II stabilization
HV180_RS21615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV180_RS21620	COG0776	regulation of translation
HV180_RS21625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV180_RS21645	COG0271	Belongs to the BolA IbaG family
HV180_RS21650	COG3056	Lipoprotein
HV180_RS21655	COG2223	nitrite transmembrane transporter activity
HV180_RS21660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV180_RS21665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV180_RS21670	COG1845	cytochrome c oxidase, subunit III
HV180_RS21675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV180_RS21690	COG1414	Transcriptional regulator
HV180_RS21695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV180_RS21710	COG1053	succinate dehydrogenase
HV180_RS21725	COG2211	Major facilitator Superfamily
HV180_RS21730	COG0673	inositol 2-dehydrogenase activity
HV180_RS21735	COG2814	Major facilitator Superfamily
HV180_RS21790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV180_RS21795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HV180_RS21800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV180_RS21805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HV180_RS21815	COG0736	holo-[acyl-carrier-protein] synthase activity
HV180_RS21820	COG2831	hemolysin activation secretion protein
HV180_RS21835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HV180_RS21860	COG0142	geranyltranstransferase activity
HV180_RS21870	COG0667	Aldo Keto reductase
HV180_RS21875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV180_RS21880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV180_RS21895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV180_RS21895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV180_RS21905	COG4238	major outer membrane lipoprotein
HV180_RS21930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV180_RS21935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV180_RS21940	COG1862	Preprotein translocase
HV180_RS21955	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HV180_RS21960	COG0450	alkyl hydroperoxide reductase
HV180_RS21965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS21980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS21990	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV180_RS22000	COG1335	isochorismatase
HV180_RS22005	COG0583	DNA-binding transcription factor activity
HV180_RS22010	COG0366	Alpha amylase catalytic
HV180_RS22035	COG0420	3'-5' exonuclease activity
HV180_RS22040	COG0419	ATPase involved in DNA repair
HV180_RS22050	COG1940	carbohydrate kinase activity
HV180_RS22065	COG4126	flavin adenine dinucleotide binding
HV180_RS22075	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV180_RS22080	COG3416	Protein conserved in bacteria
HV180_RS22090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV180_RS22100	COG1785	Belongs to the alkaline phosphatase family
HV180_RS22110	COG1609	Transcriptional regulator
HV180_RS22120	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS22155	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV180_RS22165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV180_RS22170	COG0113	porphobilinogen synthase activity
HV180_RS22175	COG1943	Transposase
HV180_RS22185	COG2175	clavaminate synthase activity
HV180_RS22190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV180_RS22195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV180_RS22200	COG4521	taurine ABC transporter
HV180_RS22215	COG2271	Major facilitator Superfamily
HV180_RS22220	COG1840	ABC-type Fe3 transport system, periplasmic component
HV180_RS22230	COG3842	ATPase activity
HV180_RS22235	COG2040	homocysteine
HV180_RS22240	COG0833	amino acid
HV180_RS22245	COG5434	Belongs to the glycosyl hydrolase 28 family
HV180_RS22255	COG4303	Ethanolamine ammonia lyase large subunit
HV180_RS22260	COG4302	ethanolamine ammonia-lyase activity
HV180_RS22295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS22305	COG0765	amino acid transport
HV180_RS22310	COG0765	amino acid transport
HV180_RS22330	COG3188	usher protein
HV180_RS22355	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV180_RS22365	COG3639	organic phosphonate transmembrane transporter activity
HV180_RS22400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV180_RS22405	COG0583	DNA-binding transcription factor activity
HV180_RS22410	COG0791	NLP P60 protein
HV180_RS22415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV180_RS22420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV180_RS22425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HV180_RS22435	COG0582	viral genome integration into host DNA
HV180_RS22470	COG4221	oxidoreductase activity
HV180_RS22500	COG0702	epimerase
HV180_RS22510	COG0667	Aldo Keto reductase
HV180_RS22515	COG0656	L-ascorbic acid biosynthetic process
HV180_RS22555	COG5002	protein histidine kinase activity
HV180_RS22565	COG0667	Aldo Keto reductase
HV180_RS22575	COG0778	Nitroreductase
HV180_RS22580	COG2814	Major facilitator Superfamily
HV180_RS22590	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV180_RS22595	COG3153	acetyltransferase
HV180_RS22610	COG0246	Mannitol dehydrogenase
HV180_RS22615	COG2186	Transcriptional regulator
HV180_RS22635	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS22640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV180_RS22650	COG1596	polysaccharide export
HV180_RS22670	COG0463	Glycosyl transferase, family 2
HV180_RS22675	COG0438	transferase activity, transferring glycosyl groups
HV180_RS22680	COG0438	transferase activity, transferring glycosyl groups
HV180_RS22680	COG0297	glycogen (starch) synthase activity
HV180_RS22695	COG1045	serine acetyltransferase
HV180_RS22715	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV180_RS22720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV180_RS22725	COG1690	Belongs to the RtcB family
HV180_RS22730	COG0454	-acetyltransferase
HV180_RS22745	COG2991	Protein conserved in bacteria
HV180_RS22760	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV180_RS22765	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV180_RS22780	COG3034	peptidoglycan biosynthetic process
HV180_RS22785	COG0121	glutamine amidotransferase
HV180_RS22795	COG1960	acyl-CoA dehydrogenase activity
HV180_RS22800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV180_RS22820	COG2226	methyltransferase
HV180_RS22830	COG1388	LysM domain
HV180_RS22830	COG0741	lytic transglycosylase activity
HV180_RS22835	COG2226	methyltransferase
HV180_RS22845	COG2814	Major facilitator Superfamily
HV180_RS22850	COG0583	DNA-binding transcription factor activity
HV180_RS22920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV180_RS22930	COG2011	ABC-type metal ion transport system permease component
HV180_RS22935	COG1464	Belongs to the NlpA lipoprotein family
HV180_RS22945	COG1720	tRNA m6t6A37 methyltransferase activity
HV180_RS22955	COG0791	NLP P60 protein
HV180_RS22960	COG3015	lipoprotein NlpE involved in copper resistance
HV180_RS22965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV180_RS22980	COG4568	rho-dependent transcription termination
HV180_RS22985	COG0037	tRNA processing
HV180_RS22990	COG0346	lactoylglutathione lyase activity
HV180_RS23035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV180_RS23040	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV180_RS23055	COG0575	Belongs to the CDS family
HV180_RS23060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HV180_RS23065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV180_RS23080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HV180_RS23090	COG0024	Methionine aminopeptidase
HV180_RS23095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HV180_RS23115	COG3835	regulator
HV180_RS23120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV180_RS23140	COG2860	membrane
HV180_RS23160	COG5464	transposase or invertase
HV180_RS23165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS23170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV180_RS23175	COG1120	ATPase activity
HV180_RS23180	COG4774	siderophore transport
HV180_RS23185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV180_RS23270	COG1643	Atp-dependent helicase
HV180_RS23275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV180_RS23295	COG0617	tRNA 3'-terminal CCA addition
HV180_RS23300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV180_RS23320	COG3539	Fimbrial protein
HV180_RS23325	COG3121	Chaperone
HV180_RS23330	COG3188	usher protein
HV180_RS23355	COG0726	polysaccharide deacetylase
HV180_RS23360	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS23365	COG0842	Transport permease protein
HV180_RS23370	COG1131	(ABC) transporter
HV180_RS23375	COG0288	reversible hydration of carbon dioxide
HV180_RS23385	COG4993	Dehydrogenase
HV180_RS23395	COG2132	Multicopper oxidase
HV180_RS23410	COG0545	Peptidyl-prolyl cis-trans isomerase
HV180_RS23435	COG3064	Membrane
HV180_RS23450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV180_RS23455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV180_RS23460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV180_RS23465	COG2186	Transcriptional regulator
HV180_RS23470	COG1113	amino acid transport
HV180_RS23475	COG2211	Major facilitator Superfamily
HV180_RS23480	COG3940	Belongs to the glycosyl hydrolase 43 family
HV180_RS23485	COG3725	Membrane protein required for beta-lactamase induction
HV180_RS23500	COG4969	Belongs to the N-Me-Phe pilin family
HV180_RS23505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV180_RS23510	COG1459	type II secretion system
HV180_RS23530	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HV180_RS23535	COG0494	nUDIX hydrolase
HV180_RS23555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV180_RS23560	COG0849	cell division
HV180_RS23585	COG0772	Belongs to the SEDS family
HV180_RS23600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV180_RS23605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV180_RS23610	COG0768	penicillin binding
HV180_RS23630	COG1609	Transcriptional regulator
HV180_RS23640	COG0028	Belongs to the TPP enzyme family
HV180_RS23655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV180_RS23680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV180_RS23685	COG0738	Major facilitator superfamily
HV180_RS23695	COG0583	DNA-binding transcription factor activity
HV180_RS23700	COG2271	Major facilitator Superfamily
HV180_RS23705	COG2814	Major facilitator Superfamily
HV180_RS23725	COG1178	ABC-type Fe3 transport system permease component
HV180_RS23735	COG0586	Pfam SNARE associated Golgi protein
HV180_RS23755	COG0235	Class ii aldolase
HV180_RS23760	COG0417	DNA replication proofreading
HV180_RS23770	COG0564	pseudouridine synthase activity
HV180_RS23780	COG3493	citrate carrier protein
HV180_RS23795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV180_RS23910	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HV180_RS23925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV180_RS23935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV180_RS23940	COG0471	metal ion transport
HV180_RS23945	COG0471	metal ion transport
HV180_RS23950	COG2828	Protein conserved in bacteria
HV180_RS23955	COG0583	DNA-binding transcription factor activity
HV180_RS23970	COG1047	Peptidyl-prolyl cis-trans
HV180_RS23985	COG0196	riboflavin kinase activity
HV180_RS23995	COG0583	DNA-binding transcription factor activity
HV180_RS24010	COG3119	arylsulfatase activity
HV180_RS24025	COG3121	Chaperone
HV180_RS24030	COG3539	Fimbrial protein
HV180_RS24035	COG3539	Fimbrial protein
HV180_RS24045	COG3188	usher protein
HV180_RS24055	COG3539	Fimbrial protein
HV180_RS24120	COG4735	regulation of single-species biofilm formation
HV180_RS24125	COG1584	GPR1 FUN34 yaaH family protein
HV180_RS24130	COG0477	Major facilitator Superfamily
HV180_RS24135	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV180_RS24140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV180_RS24145	COG1115	amino acid carrier protein
HV180_RS24155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV180_RS24165	COG0527	aspartate kinase activity
HV180_RS24165	COG0460	homoserine dehydrogenase
HV180_RS24175	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV180_RS24185	COG0745	RESPONSE REGULATOR receiver
HV180_RS24190	COG4452	Inner membrane protein CreD
HV180_RS24195	COG2205	protein histidine kinase activity
HV180_RS24200	COG0745	RESPONSE REGULATOR receiver
HV180_RS24205	COG3045	CreA protein
HV180_RS24210	COG2207	Transcriptional regulator
HV180_RS24210	COG3708	Transcriptional regulator
HV180_RS24230	COG0741	lytic transglycosylase activity
HV180_RS24235	COG0488	(ABC) transporter
HV180_RS24250	COG0560	Phosphoserine phosphatase
HV180_RS24255	COG3726	membrane protein affecting hemolysin expression
HV180_RS24265	COG0813	purine-nucleoside phosphorylase activity
HV180_RS24285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV180_RS24290	COG0084	hydrolase, TatD family'
HV180_RS24295	COG4667	esterase of the alpha-beta hydrolase superfamily
HV180_RS24300	COG5487	UPF0391 membrane protein
HV180_RS24305	COG2823	Periplasmic or secreted lipoprotein
HV180_RS24315	COG1011	Hydrolase
HV180_RS24320	COG0456	acetyltransferase
HV180_RS24325	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV180_RS24355	COG3706	GGDEF domain
HV180_RS24360	COG4114	ferric iron reductase
HV180_RS24365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS24370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV180_RS24375	COG2197	response regulator
HV180_RS24380	COG2197	response regulator
HV180_RS24385	COG2207	Transcriptional regulator
HV180_RS24395	COG2966	Psort location CytoplasmicMembrane, score
HV180_RS24410	COG1484	DNA-dependent DNA replication
HV180_RS24425	COG5464	transposase or invertase
HV180_RS24435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV180_RS24440	COG3716	PTS system mannose fructose sorbose family IID component
HV180_RS24445	COG3715	PTS system
HV180_RS24460	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HV180_RS24460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV180_RS24470	COG1063	alcohol dehydrogenase
HV180_RS24475	COG1802	Transcriptional regulator
HV180_RS24480	COG2271	Major facilitator Superfamily
HV180_RS24485	COG1214	PFAM Peptidase M22, glycoprotease
HV180_RS24485	COG0456	acetyltransferase
HV180_RS24495	COG1737	Transcriptional regulator
HV180_RS24500	COG0800	Aldolase
HV180_RS24505	COG3734	2-keto-3-deoxy-galactonokinase
HV180_RS24510	COG4145	pantothenate transmembrane transporter activity
HV180_RS24520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV180_RS24530	COG1846	Transcriptional regulator
HV180_RS24535	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV180_RS24545	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS24550	COG3384	dioxygenase
HV180_RS24560	COG3971	2-oxopent-4-enoate hydratase activity
HV180_RS24580	COG2368	4-hydroxyphenylacetate
HV180_RS24585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV180_RS24600	COG3210	domain, Protein
HV180_RS24605	COG2831	hemolysin activation secretion protein
HV180_RS24610	COG1966	Carbon starvation protein
HV180_RS24615	COG2879	small protein
HV180_RS24620	COG0523	cobalamin synthesis protein
HV180_RS24625	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS24630	COG5464	transposase or invertase
HV180_RS24645	COG0514	ATP-dependent DNA helicase (RecQ)
HV180_RS24650	COG2733	membrane
HV180_RS24655	COG2814	Major facilitator Superfamily
HV180_RS24660	COG1475	DNA binding
HV180_RS24665	COG3969	phosphoadenosine phosphosulfate
HV180_RS24675	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HV180_RS24680	COG1924	4 iron, 4 sulfur cluster binding
HV180_RS24690	COG1473	amidohydrolase
HV180_RS24695	COG0700	Nucleoside recognition
HV180_RS24700	COG3366	ferrous iron transmembrane transporter activity
HV180_RS24705	COG0583	DNA-binding transcription factor activity
HV180_RS24715	COG1566	PFAM secretion protein HlyD family protein
HV180_RS24725	COG5457	Domain of unknown function (DUF1127)
HV180_RS24730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV180_RS24740	COG0531	amino acid
HV180_RS24755	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV180_RS24790	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS24790	COG1454	alcohol dehydrogenase
HV180_RS24805	COG1882	Formate acetyltransferase
HV180_RS24810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV180_RS24820	COG4869	propanediol catabolic process
HV180_RS24850	COG0814	amino acid
HV180_RS24860	COG3706	GGDEF domain
HV180_RS24865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS24870	COG0842	Transport permease protein
HV180_RS24870	COG1129	ABC transporter
HV180_RS24875	COG0842	Transport permease protein
HV180_RS24905	COG2850	peptidyl-arginine hydroxylation
HV180_RS24910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HV180_RS24925	COG0477	Major facilitator Superfamily
HV180_RS24935	COG0477	Major facilitator Superfamily
HV180_RS24940	COG4948	Mandelate Racemase Muconate Lactonizing
HV180_RS24945	COG1028	Short-chain dehydrogenase reductase Sdr
HV180_RS24950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV180_RS25015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV180_RS25015	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HV180_RS25035	COG2003	Belongs to the UPF0758 family
HV180_RS25065	COG3596	GTP binding
HV180_RS25070	COG2378	regulation of single-species biofilm formation
HV180_RS25110	COG1715	Restriction endonuclease
HV180_RS25165	COG1064	alcohol dehydrogenase
HV180_RS25170	COG1175	transmembrane transport
HV180_RS25175	COG0395	ABC-type sugar transport system, permease component
HV180_RS25180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV180_RS25185	COG3842	ATPase activity
HV180_RS25195	COG2814	Major facilitator Superfamily
HV180_RS25205	COG1082	Xylose isomerase domain protein TIM barrel
HV180_RS25215	COG3962	Belongs to the TPP enzyme family
HV180_RS25220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS25225	COG0837	glucose binding
HV180_RS25225	COG1737	Transcriptional regulator
HV180_RS25230	COG3718	enzyme involved in inositol metabolism
HV180_RS25245	COG0433	COG0433 Predicted ATPase
HV180_RS25250	COG0795	lipopolysaccharide-transporting ATPase activity
HV180_RS25255	COG0795	lipopolysaccharide-transporting ATPase activity
HV180_RS25265	COG2927	DNA polymerase III (CHI subunit)
HV180_RS25270	COG0525	valine-tRNA ligase activity
HV180_RS25295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV180_RS25300	COG2188	Transcriptional regulator
HV180_RS25305	COG1288	antiporter activity
HV180_RS25310	COG1228	amidohydrolase
HV180_RS25315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS25320	COG2222	sugar isomerase
HV180_RS25325	COG2731	YhcH YjgK YiaL family protein
HV180_RS25350	COG3397	chitin binding
HV180_RS25355	COG0251	oxidation-reduction process
HV180_RS25370	COG1609	Transcriptional regulator
HV180_RS25375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS25375	COG1263	PTS System
HV180_RS25380	COG0366	Alpha amylase catalytic
HV180_RS25385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV180_RS25390	COG1486	melibiose metabolic process
HV180_RS25410	COG0602	queuosine metabolic process
HV180_RS25420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV180_RS25420	COG3711	transcriptional antiterminator
HV180_RS25425	COG2706	6-phosphogluconolactonase activity
HV180_RS25440	COG3964	amidohydrolase
HV180_RS25475	COG0312	modulator of DNA gyrase
HV180_RS25485	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS25485	COG1454	alcohol dehydrogenase
HV180_RS25490	COG1012	belongs to the aldehyde dehydrogenase family
HV180_RS25510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV180_RS25525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS25530	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS25535	COG1129	ABC transporter
HV180_RS25540	COG1879	ABC-type sugar transport system periplasmic component
HV180_RS25550	COG2105	PFAM AIG2 family protein
HV180_RS25555	COG2911	Protein conserved in bacteria
HV180_RS25560	COG0729	surface antigen
HV180_RS25570	COG1253	flavin adenine dinucleotide binding
HV180_RS25580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV180_RS25595	COG1733	regulation of RNA biosynthetic process
HV180_RS25600	COG0702	epimerase
HV180_RS25610	COG0697	spore germination
HV180_RS25620	COG1113	amino acid transport
HV180_RS25625	COG0545	Peptidyl-prolyl cis-trans isomerase
HV180_RS25630	COG3061	Opacity-associated protein A
HV180_RS25640	COG0359	binds to the 23S rRNA
HV180_RS25645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV180_RS25650	COG2965	DNA replication, synthesis of RNA primer
HV180_RS25710	COG1073	alpha beta
HV180_RS25715	COG3650	response to hydrogen peroxide
HV180_RS25725	COG1960	acyl-CoA dehydrogenase activity
HV180_RS25735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV180_RS25740	COG0557	exoribonuclease II activity
HV180_RS25755	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV180_RS25760	COG0330	HflC and HflK could
HV180_RS25765	COG0330	HflC and HflK could
HV180_RS25770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV180_RS25790	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV180_RS25795	COG0802	atpase or kinase
HV180_RS25800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV180_RS25800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV180_RS25805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV180_RS25825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV180_RS25830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HV180_RS25845	COG3264	Mechanosensitive ion channel
HV180_RS25845	COG1511	domain protein
HV180_RS25855	COG1053	succinate dehydrogenase
HV180_RS25860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV180_RS25875	COG3040	lipid binding
HV180_RS25880	COG2076	Multidrug Resistance protein
HV180_RS25885	COG5510	response to toxic substance
HV180_RS25900	COG1509	lysine 2,3-aminomutase activity
HV180_RS25915	COG3121	Chaperone
HV180_RS25955	COG0459	protein refolding
HV180_RS25965	COG0531	amino acid
HV180_RS25970	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV180_RS25975	COG1027	Aspartate ammonia-lyase
HV180_RS25980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV180_RS25995	COG1309	transcriptional regulator
HV180_RS26010	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV180_RS26020	COG1074	ATP-dependent DNA helicase activity
HV180_RS26050	COG2205	protein histidine kinase activity
HV180_RS26055	COG0745	RESPONSE REGULATOR receiver
HV180_RS26060	COG1276	copper resistance
HV180_RS26065	COG2372	response to copper ion
HV180_RS26070	COG3667	copper resistance
HV180_RS26075	COG2132	Multicopper oxidase
HV180_RS26085	COG0739	heme binding
HV180_RS26115	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV180_RS26355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV180_RS26395	COG0305	Participates in initiation and elongation during chromosome replication
HV180_RS26415	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV180_RS26430	COG0861	Integral membrane protein TerC family
HV180_RS26460	COG2169	Transcriptional regulator
HV180_RS26470	COG2824	Alkylphosphonate utilization operon protein PhnA
HV180_RS26475	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV180_RS26480	COG2188	Transcriptional regulator
HV180_RS26485	COG3624	Phosphonate C-P lyase system protein PhnG
HV180_RS26490	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV180_RS26495	COG3626	phosphonate metabolism
HV180_RS26500	COG3627	carbon phosphorus lyase activity
HV180_RS26505	COG4107	phosphonate C-P lyase system protein PhnK
HV180_RS26510	COG4778	phosphonate C-P lyase system protein PhnL
HV180_RS26515	COG3454	Phosphonate metabolism
HV180_RS26525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV180_RS26555	COG0698	ribose 5-phosphate isomerase
HV180_RS26560	COG1737	Transcriptional regulator
HV180_RS26565	COG1879	ABC-type sugar transport system periplasmic component
HV180_RS26570	COG1129	ABC transporter
HV180_RS26575	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS26580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV180_RS26585	COG1940	carbohydrate kinase activity
HV180_RS26595	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV180_RS26600	COG1301	dicarboxylic acid transport
HV180_RS26605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HV180_RS26610	COG3162	membrane
HV180_RS26655	COG0583	DNA-binding transcription factor activity
HV180_RS26660	COG0025	NhaP-type Na H and K H
HV180_RS26665	COG2252	PERMEase
HV180_RS26685	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV180_RS26700	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV180_RS26710	COG4771	TonB-dependent receptor
HV180_RS26715	COG0741	lytic transglycosylase activity
HV180_RS26720	COG0629	single-stranded DNA binding
HV180_RS26740	COG2315	Protein conserved in bacteria
HV180_RS26745	COG0432	Pfam Uncharacterised protein family UPF0047
HV180_RS26755	COG1448	Aminotransferase
HV180_RS26765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV180_RS26770	COG0305	Participates in initiation and elongation during chromosome replication
HV180_RS26785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV180_RS26795	COG0735	belongs to the Fur family
HV180_RS26800	COG3237	CsbD-like
HV180_RS26805	COG0534	Mate efflux family protein
HV180_RS26815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV180_RS26865	COG2814	Major facilitator Superfamily
HV180_RS26865	COG0477	Major facilitator Superfamily
HV180_RS26900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV180_RS26910	COG0527	aspartate kinase activity
HV180_RS26920	COG3541	Predicted nucleotidyltransferase
HV180_RS26925	COG0330	HflC and HflK could
HV180_RS26930	COG4650	regulator
HV180_RS26945	COG1187	pseudouridine synthase activity
HV180_RS26985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV180_RS27025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV180_RS27065	COG0151	Belongs to the GarS family
HV180_RS27075	COG4191	Histidine kinase
HV180_RS27115	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HV180_RS27130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV180_RS27135	COG2104	thiamine diphosphate biosynthetic process
HV180_RS27145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HV180_RS27150	COG3706	GGDEF domain
HV180_RS27160	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV180_RS27165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV180_RS27200	COG0250	Participates in transcription elongation, termination and antitermination
HV180_RS27205	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV180_RS27245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV180_RS27275	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HV180_RS27285	COG1739	Uncharacterized protein family UPF0029
HV180_RS27330	COG0805	protein transport
HV180_RS27350	COG3165	ubiquinone biosynthetic process from chorismate
HV180_RS27380	COG0583	DNA-binding transcription factor activity
HV180_RS27395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HV180_RS27400	COG2828	Protein conserved in bacteria
HV180_RS27405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV180_RS27410	COG0473	3-isopropylmalate dehydrogenase activity
HV180_RS27415	COG1049	propionate catabolic process, 2-methylcitrate cycle
HV180_RS27420	COG2188	Transcriptional regulator
HV180_RS27435	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV180_RS27445	COG2301	Belongs to the HpcH HpaI aldolase family
HV180_RS27450	COG3051	citrate lyase alpha subunit
HV180_RS27465	COG0511	ligase activity, forming carbon-carbon bonds
HV180_RS27465	COG5016	pyruvate
HV180_RS27470	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HV180_RS27480	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV180_RS27485	COG0641	radical SAM
HV180_RS27490	COG2188	Transcriptional regulator
HV180_RS27495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HV180_RS27500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV180_RS27500	COG1263	PTS System
HV180_RS27510	COG0583	DNA-binding transcription factor activity
HV180_RS27515	COG0697	spore germination
HV180_RS27520	COG0561	phosphatase activity
HV180_RS27525	COG2267	carboxylic ester hydrolase activity
HV180_RS27530	COG1280	lysine exporter protein (LysE YggA)
HV180_RS27540	COG1280	lysine exporter protein (LysE YggA)
HV180_RS27555	COG2050	protein possibly involved in aromatic compounds catabolism
HV180_RS27565	COG0598	Magnesium transport protein CorA
HV180_RS27570	COG0210	DNA helicase
HV180_RS27575	COG1011	Hydrolase
HV180_RS27595	COG5567	small periplasmic lipoprotein
HV180_RS27605	COG3072	Adenylate cyclase
HV180_RS27615	COG1587	Uroporphyrinogen-III synthase
HV180_RS27620	COG2959	enzyme of heme biosynthesis
HV180_RS27625	COG3071	HemY protein
HV180_RS27670	COG2244	polysaccharide biosynthetic process
HV180_RS27675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV180_RS27680	COG0456	acetyltransferase
HV180_RS27685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV180_RS27690	COG1088	dTDP-glucose 4,6-dehydratase activity
HV180_RS27695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV180_RS27700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV180_RS27710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV180_RS27715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV180_RS27720	COG3118	belongs to the thioredoxin family
HV180_RS27735	COG0583	DNA-binding transcription factor activity
HV180_RS27745	COG1811	Na channel or pump
HV180_RS27755	COG1397	ADP-ribosylglycohydrolase
HV180_RS27765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS27790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV180_RS27795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV180_RS27815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV180_RS27825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV180_RS27830	COG3978	acetolactate synthase activity
HV180_RS27850	COG3085	chromosome segregation
HV180_RS27925	COG0583	DNA-binding transcription factor activity
HV180_RS27940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV180_RS27955	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV180_RS27965	COG2207	Transcriptional regulator
HV180_RS27975	COG0371	Dehydrogenase
HV180_RS27985	COG0697	spore germination
HV180_RS27995	COG0583	DNA-binding transcription factor activity
HV180_RS28015	COG0460	homoserine dehydrogenase
HV180_RS28015	COG0527	aspartate kinase activity
HV180_RS28020	COG0626	cystathionine gamma-synthase activity
HV180_RS28030	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HV180_RS28045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV180_RS28050	COG1609	Transcriptional regulator
HV180_RS28055	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV180_RS28070	COG1575	Belongs to the MenA family. Type 1 subfamily
HV180_RS28090	COG3678	ATP-independent chaperone mediated protein folding
HV180_RS28095	COG0745	RESPONSE REGULATOR receiver
HV180_RS28100	COG2205	protein histidine kinase activity
HV180_RS28105	COG2258	MOSC domain
HV180_RS28110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV180_RS28150	COG1129	ABC transporter
HV180_RS28155	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS28165	COG1454	alcohol dehydrogenase
HV180_RS28180	COG2211	Major facilitator Superfamily
HV180_RS28185	COG1609	Transcriptional regulator
HV180_RS28195	COG0110	maltose O-acetyltransferase activity
HV180_RS28200	COG2211	Major facilitator Superfamily
HV180_RS28220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV180_RS28265	COG0205	6-phosphofructokinase activity
HV180_RS28295	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV180_RS28305	COG3715	PTS system
HV180_RS28310	COG3716	PTS system mannose fructose sorbose family IID component
HV180_RS28335	COG0437	4 iron, 4 sulfur cluster binding
HV180_RS28340	COG2864	formate dehydrogenase
HV180_RS28355	COG0456	acetyltransferase
HV180_RS28360	COG1490	D-aminoacyl-tRNA deacylase activity
HV180_RS28370	COG1011	Hydrolase
HV180_RS28385	COG3852	Histidine kinase
HV180_RS28400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV180_RS28420	COG0204	Acyl-transferase
HV180_RS28430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HV180_RS28435	COG3084	Protein conserved in bacteria
HV180_RS28440	COG0746	molybdenum cofactor guanylyltransferase activity
HV180_RS28445	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV180_RS28465	COG2186	Transcriptional regulator
HV180_RS28470	COG0477	Major facilitator Superfamily
HV180_RS28475	COG1609	Transcriptional regulator
HV180_RS28480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV180_RS28490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV180_RS28495	COG1129	ABC transporter
HV180_RS28525	COG1522	sequence-specific DNA binding
HV180_RS28530	COG0716	FMN binding
HV180_RS28545	COG3312	ion transport
HV180_RS28605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV180_RS28610	COG0573	inorganic phosphate transmembrane transporter activity
HV180_RS28615	COG0581	inorganic phosphate transmembrane transporter activity
HV180_RS28620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HV180_RS28625	COG0704	Plays a role in the regulation of phosphate uptake
HV180_RS28635	COG2382	esterase
HV180_RS28640	COG0363	glucosamine-6-phosphate deaminase activity
HV180_RS28645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV180_RS28650	COG2252	PERMEase
HV180_RS28655	COG0431	NADPH-dependent FMN reductase
HV180_RS28660	COG2091	lysine biosynthetic process via aminoadipic acid
HV180_RS28675	COG2731	YhcH YjgK YiaL family protein
HV180_RS28695	COG1737	Transcriptional regulator
HV180_RS28700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV180_RS28720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HV180_RS28730	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV180_RS28780	COG2223	nitrite transmembrane transporter activity
HV180_RS28830	COG5642	Protein of unknown function (DUF2384)
HV180_RS28835	COG5654	RES domain protein
HV180_RS28865	COG0745	RESPONSE REGULATOR receiver
HV180_RS28870	COG5002	protein histidine kinase activity
HV180_RS28870	COG0784	Response regulator, receiver
HV180_RS28870	COG2198	Histidine kinase
HV180_RS28875	COG0683	leucine binding
HV180_RS28900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV180_RS28930	COG0071	Belongs to the small heat shock protein (HSP20) family
HV180_RS28935	COG0542	response to heat
HV180_RS29000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV180_RS29005	COG3039	Transposase
HV180_RS29050	COG2826	transposase and inactivated derivatives, IS30 family
HV180_RS29085	COG2801	Transposase and inactivated derivatives
HV180_RS29125	COG5499	transcription regulator containing HTH domain
HV180_RS29130	COG4680	protein conserved in bacteria
HV180_RS29145	COG3436	PFAM IS66 Orf2 family protein
HV180_RS29180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HV180_RS29190	COG0589	response to stress
HV180_RS29195	COG0659	secondary active sulfate transmembrane transporter activity
HV180_RS29205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV180_RS29210	COG1393	Belongs to the ArsC family
HV180_RS29220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV180_RS29295	COG4598	ABC transporter
HV180_RS29315	COG0583	DNA-binding transcription factor activity
HV180_RS29365	COG3706	GGDEF domain
HV180_RS29385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV180_RS29415	COG0431	NADPH-dependent FMN reductase
HV180_RS29440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV180_RS29450	COG1595	DNA-templated transcription, initiation
HV180_RS29455	COG3712	iron ion homeostasis
HV180_RS29460	COG4772	TonB-dependent receptor
HV180_RS29465	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV180_RS29470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS29475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV180_RS29480	COG1120	ATPase activity
HV180_RS29485	COG3436	PFAM IS66 Orf2 family protein
HV180_RS29510	COG0640	Transcriptional regulator
HV180_RS29515	COG0431	NADPH-dependent FMN reductase
HV180_RS29555	COG2223	nitrite transmembrane transporter activity
HV180_RS29585	COG0418	dihydroorotase activity
HV180_RS29600	COG0543	2 iron, 2 sulfur cluster binding
HV180_RS29605	COG2814	Major facilitator Superfamily
HV180_RS29615	COG3039	Transposase
HV180_RS29620	COG2372	response to copper ion
HV180_RS29740	COG4372	Transposase
HV180_RS29745	COG3436	PFAM IS66 Orf2 family protein