locus-tag	class	description
C2D60_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2D60_RS00020	COG0187	DNA topoisomerase II activity
C2D60_RS00025	COG0561	phosphatase activity
C2D60_RS00040	COG2186	Transcriptional regulator
C2D60_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
C2D60_RS00050	COG0800	Aldolase
C2D60_RS00060	COG2271	Major facilitator Superfamily
C2D60_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
C2D60_RS00070	COG5645	(Lipo)protein
C2D60_RS00085	COG3645	SOS response
C2D60_RS00095	COG2188	Transcriptional regulator
C2D60_RS00110	COG2149	membrane
C2D60_RS00130	COG2610	gluconate transmembrane transporter activity
C2D60_RS00135	COG0583	DNA-binding transcription factor activity
C2D60_RS00140	COG2814	Major facilitator Superfamily
C2D60_RS00165	COG0028	Belongs to the TPP enzyme family
C2D60_RS00170	COG0440	acetolactate synthase activity
C2D60_RS00175	COG2197	response regulator
C2D60_RS00185	COG2271	Major facilitator Superfamily
C2D60_RS00230	COG2188	Transcriptional regulator
C2D60_RS00255	COG4580	involved in the transport of maltose and maltodextrins
C2D60_RS00260	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D60_RS00265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS00265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS00275	COG1609	Transcriptional regulator
C2D60_RS00285	COG3384	dioxygenase
C2D60_RS00290	COG0583	DNA-binding transcription factor activity
C2D60_RS00295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2D60_RS00300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2D60_RS00305	COG2828	Protein conserved in bacteria
C2D60_RS00320	COG0697	spore germination
C2D60_RS00325	COG1263	PTS System
C2D60_RS00325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS00335	COG2814	Major facilitator Superfamily
C2D60_RS00345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D60_RS00375	COG0583	DNA-binding transcription factor activity
C2D60_RS00400	COG1464	Belongs to the NlpA lipoprotein family
C2D60_RS00415	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2D60_RS00425	COG1064	alcohol dehydrogenase
C2D60_RS00480	COG0582	viral genome integration into host DNA
C2D60_RS00490	COG2211	Major facilitator Superfamily
C2D60_RS00495	COG1501	Belongs to the glycosyl hydrolase 31 family
C2D60_RS00505	COG1486	melibiose metabolic process
C2D60_RS00510	COG1263	PTS System
C2D60_RS00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS00515	COG2982	Protein involved in outer membrane biogenesis
C2D60_RS00520	COG2233	PERMEase
C2D60_RS00525	COG0786	glutamate:sodium symporter activity
C2D60_RS00545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2D60_RS00570	COG3152	Membrane
C2D60_RS00580	COG1494	fructose-1,6-bisphosphatase
C2D60_RS00585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2D60_RS00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D60_RS00595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2D60_RS00615	COG2860	membrane
C2D60_RS00625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2D60_RS00625	COG2169	Transcriptional regulator
C2D60_RS00630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2D60_RS00635	COG1561	YicC-like family, N-terminal region
C2D60_RS00665	COG1131	(ABC) transporter
C2D60_RS00670	COG0842	Transport permease protein
C2D60_RS00700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2D60_RS00735	COG1519	Transferase
C2D60_RS00740	COG1216	Glycosyl transferase, family 2
C2D60_RS00745	COG0438	transferase activity, transferring glycosyl groups
C2D60_RS00755	COG0859	PFAM glycosyl transferase family 9
C2D60_RS00780	COG0859	PFAM glycosyl transferase family 9
C2D60_RS00795	COG0156	8-amino-7-oxononanoate synthase activity
C2D60_RS00805	COG0463	Glycosyl transferase, family 2
C2D60_RS00810	COG2861	carbohydrate metabolic process
C2D60_RS00815	COG4942	peptidase
C2D60_RS00825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2D60_RS00830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2D60_RS00850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2D60_RS00860	COG2186	Transcriptional regulator
C2D60_RS00880	COG3722	fumarate hydratase activity
C2D60_RS00900	COG0625	glutathione transferase activity
C2D60_RS00910	COG3276	selenocysteine insertion sequence binding
C2D60_RS00915	COG1414	Transcriptional regulator
C2D60_RS00920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D60_RS00925	COG3977	Valine--pyruvate aminotransferase
C2D60_RS00930	COG0366	Alpha amylase catalytic
C2D60_RS00935	COG2992	FlgJ-related protein
C2D60_RS00940	COG2207	Transcriptional regulator
C2D60_RS00940	COG1609	Transcriptional regulator
C2D60_RS00945	COG4214	carbohydrate transport
C2D60_RS00955	COG4213	ABC transporter substrate-binding protein
C2D60_RS00975	COG4682	membrane
C2D60_RS00980	COG4682	membrane
C2D60_RS00985	COG3274	enterobacterial common antigen metabolic process
C2D60_RS01020	COG1278	Cold shock
C2D60_RS01025	COG2944	sequence-specific DNA binding
C2D60_RS01030	COG2814	Major facilitator Superfamily
C2D60_RS01055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D60_RS01065	COG1609	Transcriptional regulator
C2D60_RS01070	COG2885	chlorophyll binding
C2D60_RS01075	COG0243	molybdopterin cofactor binding
C2D60_RS01080	COG0456	acetyltransferase
C2D60_RS01085	COG2818	Glycosylase
C2D60_RS01090	COG5571	outer membrane autotransporter
C2D60_RS01095	COG2223	nitrite transmembrane transporter activity
C2D60_RS01125	COG0747	negative chemotaxis
C2D60_RS01130	COG0601	transmembrane transport
C2D60_RS01135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D60_RS01140	COG0444	Belongs to the ABC transporter superfamily
C2D60_RS01145	COG4608	Belongs to the ABC transporter superfamily
C2D60_RS01160	COG2894	cell division
C2D60_RS01170	COG1215	transferase activity, transferring glycosyl groups
C2D60_RS01175	COG0457	Tetratricopeptide repeat
C2D60_RS01190	COG2194	sulfuric ester hydrolase activity
C2D60_RS01220	COG1215	transferase activity, transferring glycosyl groups
C2D60_RS01225	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2D60_RS01230	COG3118	belongs to the thioredoxin family
C2D60_RS01230	COG0457	Tetratricopeptide repeat
C2D60_RS01235	COG2200	EAL domain
C2D60_RS01235	COG2199	diguanylate cyclase activity
C2D60_RS01245	COG0612	Peptidase, M16
C2D60_RS01260	COG2982	Protein involved in outer membrane biogenesis
C2D60_RS01265	COG0477	Major facilitator Superfamily
C2D60_RS01270	COG1295	ribonuclease BN
C2D60_RS01275	COG0583	DNA-binding transcription factor activity
C2D60_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS01285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D60_RS01295	COG1454	alcohol dehydrogenase
C2D60_RS01305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D60_RS01310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2D60_RS01315	COG0671	phosphoesterase, PA-phosphatase related
C2D60_RS01335	COG0589	response to stress
C2D60_RS01345	COG0306	phosphate transporter
C2D60_RS01350	COG2081	HI0933 family
C2D60_RS01355	COG2239	Acts as a magnesium transporter
C2D60_RS01370	COG1124	(ABC) transporter
C2D60_RS01380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D60_RS01385	COG0601	transmembrane transport
C2D60_RS01390	COG0747	negative chemotaxis
C2D60_RS01405	COG3479	Phenolic acid decarboxylase
C2D60_RS01445	COG0628	permease
C2D60_RS01450	COG0477	Major facilitator Superfamily
C2D60_RS01460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2D60_RS01475	COG3714	YhhN family
C2D60_RS01485	COG3776	membrane
C2D60_RS01490	COG0742	ribosomal rna small subunit methyltransferase
C2D60_RS01495	COG0552	protein localization to endoplasmic reticulum
C2D60_RS01500	COG2884	Cell division ATP-binding protein ftsE
C2D60_RS01505	COG2177	Part of the ABC transporter FtsEX involved in
C2D60_RS01520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D60_RS01530	COG0683	leucine binding
C2D60_RS01545	COG0683	leucine binding
C2D60_RS01550	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS01600	COG0584	glycerophosphoryl diester phosphodiesterase
C2D60_RS01610	COG0405	Gamma-glutamyltransferase
C2D60_RS01615	COG1247	-acetyltransferase
C2D60_RS01625	COG0673	inositol 2-dehydrogenase activity
C2D60_RS01630	COG1741	Belongs to the pirin family
C2D60_RS01635	COG1609	Transcriptional regulator
C2D60_RS01640	COG3265	gluconokinase activity
C2D60_RS01645	COG2610	gluconate transmembrane transporter activity
C2D60_RS01655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D60_RS01680	COG0058	SHG alpha-glucan phosphorylase activity
C2D60_RS01685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2D60_RS01700	COG1349	DNA-binding transcription factor activity
C2D60_RS01715	COG0058	SHG alpha-glucan phosphorylase activity
C2D60_RS01720	COG1640	4-alpha-glucanotransferase
C2D60_RS01725	COG2610	gluconate transmembrane transporter activity
C2D60_RS01735	COG1040	competence protein
C2D60_RS01760	COG1918	ferrous iron import across plasma membrane
C2D60_RS01765	COG2183	response to ionizing radiation
C2D60_RS01770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2D60_RS01795	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2D60_RS01800	COG1011	Hydrolase
C2D60_RS01810	COG0494	nUDIX hydrolase
C2D60_RS01815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2D60_RS01840	COG4796	Type ii and iii secretion system protein
C2D60_RS01860	COG3266	domain, Protein
C2D60_RS01865	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2D60_RS01870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D60_RS01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2D60_RS01900	COG0402	S-adenosylhomocysteine deaminase activity
C2D60_RS01905	COG0738	Major facilitator superfamily
C2D60_RS01930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2D60_RS01935	COG1289	transmembrane transporter activity
C2D60_RS01945	COG1765	OsmC-like protein
C2D60_RS01950	COG3954	Phosphoribulokinase
C2D60_RS01960	COG0429	hydrolase of the alpha beta-hydrolase fold
C2D60_RS01970	COG0488	(ABC) transporter
C2D60_RS01985	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2D60_RS01990	COG1047	Peptidyl-prolyl cis-trans
C2D60_RS02000	COG0545	Peptidyl-prolyl cis-trans isomerase
C2D60_RS02005	COG2964	Protein conserved in bacteria
C2D60_RS02060	COG0051	transcription antitermination factor activity, RNA binding
C2D60_RS02085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2D60_RS02100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2D60_RS02165	COG0201	protein transport
C2D60_RS02190	COG0202	RNA polymerase activity
C2D60_RS02205	COG0789	Transcriptional regulator
C2D60_RS02210	COG3036	rescue of stalled ribosome
C2D60_RS02250	COG0551	DNA topoisomerase type I activity
C2D60_RS02270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D60_RS02305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D60_RS02310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS02315	COG1309	transcriptional regulator
C2D60_RS02340	COG4145	pantothenate transmembrane transporter activity
C2D60_RS02345	COG3924	membrane
C2D60_RS02350	COG0439	Biotin carboxylase
C2D60_RS02355	COG0511	ligase activity, forming carbon-carbon bonds
C2D60_RS02380	COG2199	diguanylate cyclase activity
C2D60_RS02380	COG2200	EAL domain
C2D60_RS02385	COG1077	Cell shape determining protein MreB Mrl
C2D60_RS02390	COG1792	Involved in formation and maintenance of cell shape
C2D60_RS02395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2D60_RS02405	COG1530	ribonuclease E activity
C2D60_RS02410	COG3164	Protein of unknown function
C2D60_RS02415	COG0312	modulator of DNA gyrase
C2D60_RS02420	COG0583	DNA-binding transcription factor activity
C2D60_RS02435	COG1289	transmembrane transporter activity
C2D60_RS02440	COG2732	(Barnase) inhibitor
C2D60_RS02495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D60_RS02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D60_RS02505	COG3105	Protein conserved in bacteria
C2D60_RS02510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2D60_RS02530	COG0625	glutathione transferase activity
C2D60_RS02535	COG2969	positive regulation of protein catabolic process
C2D60_RS02545	COG0493	'glutamate synthase
C2D60_RS02550	COG0070	glutamate synthase
C2D60_RS02550	COG0069	glutamate synthase activity
C2D60_RS02550	COG0067	glutamate synthase
C2D60_RS02555	COG1242	4 iron, 4 sulfur cluster binding
C2D60_RS02560	COG2271	Major facilitator Superfamily
C2D60_RS02565	COG1063	alcohol dehydrogenase
C2D60_RS02570	COG1312	Catalyzes the dehydration of D-mannonate
C2D60_RS02575	COG5002	protein histidine kinase activity
C2D60_RS02575	COG0784	Response regulator, receiver
C2D60_RS02575	COG2198	Histidine kinase
C2D60_RS02580	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2D60_RS02585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2D60_RS02590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS02600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS02605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2D60_RS02610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2D60_RS02615	COG1137	ATPase activity
C2D60_RS02620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2D60_RS02625	COG3117	lipopolysaccharide transmembrane transporter activity
C2D60_RS02630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2D60_RS02640	COG0530	calcium, potassium:sodium antiporter activity
C2D60_RS02650	COG1127	ABC transporter
C2D60_RS02655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2D60_RS02660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2D60_RS02665	COG2854	intermembrane phospholipid transfer
C2D60_RS02670	COG3113	response to antibiotic
C2D60_RS02675	COG5007	Belongs to the BolA IbaG family
C2D60_RS02685	COG3423	Transcriptional regulator
C2D60_RS02690	COG0142	geranyltranstransferase activity
C2D60_RS02705	COG0697	spore germination
C2D60_RS02715	COG2027	D-alanyl-D-alanine carboxypeptidase
C2D60_RS02725	COG1534	Rna-binding protein
C2D60_RS02735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2D60_RS02740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2D60_RS02750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2D60_RS02790	COG0195	Participates in both transcription termination and antitermination
C2D60_RS02840	COG0814	amino acid
C2D60_RS02845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D60_RS02850	COG0826	peptidase U32
C2D60_RS02855	COG0826	peptidase U32
C2D60_RS02860	COG3154	lipid carrier protein
C2D60_RS02865	COG3153	acetyltransferase
C2D60_RS02880	COG0693	protein deglycase activity
C2D60_RS02885	COG0702	epimerase
C2D60_RS02890	COG0701	Predicted permease
C2D60_RS02895	COG2823	Periplasmic or secreted lipoprotein
C2D60_RS02915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2D60_RS02930	COG1063	alcohol dehydrogenase
C2D60_RS02935	COG3775	system Galactitol-specific IIC component
C2D60_RS02940	COG3414	Phosphotransferase system galactitol-specific IIB component
C2D60_RS02945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS02955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS02955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS02960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS02960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS02960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS02965	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D60_RS02975	COG1349	DNA-binding transcription factor activity
C2D60_RS02980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D60_RS02985	COG2721	sulfolactate sulfo-lyase activity
C2D60_RS02995	COG2271	Major facilitator Superfamily
C2D60_RS03005	COG2084	Dehydrogenase
C2D60_RS03010	COG1929	Belongs to the glycerate kinase type-1 family
C2D60_RS03030	COG1741	Belongs to the pirin family
C2D60_RS03035	COG0583	DNA-binding transcription factor activity
C2D60_RS03040	COG3152	Membrane
C2D60_RS03045	COG0435	Glutathione S-transferase
C2D60_RS03050	COG2259	Doxx family
C2D60_RS03060	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2D60_RS03065	COG4575	ribosome binding
C2D60_RS03070	COG1422	Protein of unknown function (DUF1090)
C2D60_RS03080	COG0586	Pfam SNARE associated Golgi protein
C2D60_RS03085	COG2186	Transcriptional regulator
C2D60_RS03090	COG2271	Major facilitator Superfamily
C2D60_RS03100	COG2721	sulfolactate sulfo-lyase activity
C2D60_RS03115	COG0861	Integral membrane protein TerC family
C2D60_RS03120	COG0673	inositol 2-dehydrogenase activity
C2D60_RS03125	COG1451	nucleotide metabolic process
C2D60_RS03145	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2D60_RS03145	COG1902	pentaerythritol trinitrate reductase activity
C2D60_RS03195	COG1695	Transcriptional regulator
C2D60_RS03200	COG2375	cellular response to nickel ion
C2D60_RS03215	COG1461	Dihydroxyacetone kinase
C2D60_RS03220	COG2376	Dihydroxyacetone kinase
C2D60_RS03295	COG3247	response to pH
C2D60_RS03305	COG2205	protein histidine kinase activity
C2D60_RS03305	COG0784	Response regulator, receiver
C2D60_RS03305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS03305	COG2198	Histidine kinase
C2D60_RS03310	COG2197	response regulator
C2D60_RS03335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2D60_RS03340	COG0358	DNA primase activity
C2D60_RS03345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2D60_RS03405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2D60_RS03420	COG4991	sh3 domain protein
C2D60_RS03425	COG3025	triphosphatase activity
C2D60_RS03445	COG2960	long-chain fatty acid transporting porin activity
C2D60_RS03460	COG3384	dioxygenase
C2D60_RS03465	COG0754	glutathionylspermidine amidase activity
C2D60_RS03480	COG0494	nUDIX hydrolase
C2D60_RS03485	COG3151	Protein conserved in bacteria
C2D60_RS03490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2D60_RS03495	COG3150	esterase
C2D60_RS03505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2D60_RS03515	COG0642	Histidine kinase
C2D60_RS03525	COG3111	PFAM Bacterial OB fold (BOF) protein
C2D60_RS03530	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2D60_RS03535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2D60_RS03540	COG0204	Acyl-transferase
C2D60_RS03545	COG2132	Multicopper oxidase
C2D60_RS03550	COG1032	radical SAM domain protein
C2D60_RS03560	COG0656	L-ascorbic acid biosynthetic process
C2D60_RS03565	COG1979	alcohol dehydrogenase
C2D60_RS03570	COG2207	Transcriptional regulator
C2D60_RS03575	COG0586	Pfam SNARE associated Golgi protein
C2D60_RS03580	COG0626	cystathionine gamma-synthase activity
C2D60_RS03590	COG0848	biopolymer transport protein
C2D60_RS03595	COG2211	Major facilitator Superfamily
C2D60_RS03620	COG0625	glutathione transferase activity
C2D60_RS03630	COG0754	glutathionylspermidine amidase activity
C2D60_RS03635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D60_RS03660	COG0626	cystathionine gamma-synthase activity
C2D60_RS03700	COG1811	Na channel or pump
C2D60_RS03710	COG1982	Orn Lys Arg decarboxylase major
C2D60_RS03715	COG2211	Major facilitator Superfamily
C2D60_RS03730	COG1194	a g-specific adenine glycosylase
C2D60_RS03740	COG3171	Protein conserved in bacteria
C2D60_RS03750	COG4214	carbohydrate transport
C2D60_RS03765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2D60_RS03780	COG0762	integral membrane protein
C2D60_RS03785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2D60_RS03790	COG2805	Type II/IV secretion system protein
C2D60_RS03810	COG0189	ligase activity
C2D60_RS03815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2D60_RS03820	COG2356	endonuclease I
C2D60_RS03830	COG2814	Major facilitator Superfamily
C2D60_RS03865	COG0501	Belongs to the peptidase M48B family
C2D60_RS03870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D60_RS03885	COG0191	fructose-bisphosphate aldolase activity
C2D60_RS03890	COG0668	transmembrane transport
C2D60_RS03900	COG2968	Membrane
C2D60_RS03915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D60_RS03920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2D60_RS03940	COG0006	proline dipeptidase activity
C2D60_RS03945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D60_RS03950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D60_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS03975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2D60_RS03995	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS04000	COG1737	Transcriptional regulator
C2D60_RS04010	COG1272	protein, Hemolysin III
C2D60_RS04020	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2D60_RS04030	COG0716	FMN binding
C2D60_RS04035	COG4974	Belongs to the 'phage' integrase family
C2D60_RS04045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2D60_RS04070	COG4942	peptidase
C2D60_RS04080	COG2814	Major facilitator Superfamily
C2D60_RS04095	COG0667	Aldo Keto reductase
C2D60_RS04135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2D60_RS04140	COG1393	Belongs to the ArsC family
C2D60_RS04155	COG1538	Outer membrane efflux protein
C2D60_RS04160	COG1289	transmembrane transporter activity
C2D60_RS04175	COG3592	Divergent 4Fe-4S mono-cluster
C2D60_RS04180	COG2388	GCN5-related N-acetyl-transferase
C2D60_RS04190	COG3539	Fimbrial protein
C2D60_RS04195	COG3539	Fimbrial protein
C2D60_RS04200	COG3539	Fimbrial protein
C2D60_RS04205	COG3188	usher protein
C2D60_RS04210	COG3121	Chaperone
C2D60_RS04215	COG3539	Fimbrial protein
C2D60_RS04225	COG4974	Belongs to the 'phage' integrase family
C2D60_RS04230	COG0582	viral genome integration into host DNA
C2D60_RS04240	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D60_RS04245	COG1846	Transcriptional regulator
C2D60_RS04250	COG0697	spore germination
C2D60_RS04300	COG0667	Aldo Keto reductase
C2D60_RS04305	COG0814	amino acid
C2D60_RS04320	COG0183	Belongs to the thiolase family
C2D60_RS04330	COG0823	Involved in the tonB-independent uptake of proteins
C2D60_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS04340	COG2814	Major facilitator Superfamily
C2D60_RS04370	COG3842	ATPase activity
C2D60_RS04375	COG0395	ABC-type sugar transport system, permease component
C2D60_RS04380	COG1175	transmembrane transport
C2D60_RS04385	COG1917	Cupin 2, conserved barrel domain protein
C2D60_RS04390	COG1794	racemase activity, acting on amino acids and derivatives
C2D60_RS04395	COG0583	DNA-binding transcription factor activity
C2D60_RS04405	COG1609	Transcriptional regulator
C2D60_RS04410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS04415	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS04420	COG2186	Transcriptional regulator
C2D60_RS04430	COG1609	Transcriptional regulator
C2D60_RS04455	COG0667	Aldo Keto reductase
C2D60_RS04465	COG0861	Integral membrane protein TerC family
C2D60_RS04500	COG2165	general secretion pathway protein
C2D60_RS04505	COG4795	General secretion pathway protein
C2D60_RS04515	COG4967	type IV pilus modification protein PilV
C2D60_RS04520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2D60_RS04525	COG1025	Belongs to the peptidase M16 family
C2D60_RS04530	COG1074	ATP-dependent DNA helicase activity
C2D60_RS04535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2D60_RS04545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2D60_RS04545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2D60_RS04550	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D60_RS04555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2D60_RS04585	COG4656	Part of a membrane complex involved in electron transport
C2D60_RS04590	COG1454	alcohol dehydrogenase
C2D60_RS04590	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS04620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2D60_RS04785	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2D60_RS04790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2D60_RS04795	COG2166	iron-sulfur cluster assembly
C2D60_RS04800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2D60_RS04810	COG0583	DNA-binding transcription factor activity
C2D60_RS04815	COG2363	Small membrane protein
C2D60_RS04825	COG1349	DNA-binding transcription factor activity
C2D60_RS04845	COG0738	Major facilitator superfamily
C2D60_RS04850	COG0235	Class ii aldolase
C2D60_RS04855	COG1454	alcohol dehydrogenase
C2D60_RS04870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D60_RS04885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2D60_RS04890	COG2011	ABC-type metal ion transport system permease component
C2D60_RS04895	COG1464	Belongs to the NlpA lipoprotein family
C2D60_RS04905	COG0477	Major facilitator Superfamily
C2D60_RS04915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D60_RS04920	COG1760	l-serine dehydratase
C2D60_RS04925	COG0814	amino acid
C2D60_RS04930	COG1611	Belongs to the LOG family
C2D60_RS04945	COG3098	single-species biofilm formation
C2D60_RS04950	COG0564	pseudouridine synthase activity
C2D60_RS04955	COG0716	FMN binding
C2D60_RS04965	COG2271	Major facilitator Superfamily
C2D60_RS04970	COG4948	Mandelate Racemase Muconate Lactonizing
C2D60_RS04975	COG4948	Mandelate Racemase Muconate Lactonizing
C2D60_RS04980	COG1929	Belongs to the glycerate kinase type-1 family
C2D60_RS04990	COG3437	response regulator, receiver
C2D60_RS04990	COG2205	protein histidine kinase activity
C2D60_RS04990	COG3850	Histidine kinase
C2D60_RS04990	COG4999	Histidine kinase
C2D60_RS05000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2D60_RS05005	COG3956	TIGRFAM MazG family protein
C2D60_RS05025	COG0602	queuosine metabolic process
C2D60_RS05030	COG0720	synthase
C2D60_RS05050	COG2234	aminopeptidase activity
C2D60_RS05110	COG4942	peptidase
C2D60_RS05110	COG1388	LysM domain
C2D60_RS05115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2D60_RS05140	COG0163	prenyltransferase activity
C2D60_RS05145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2D60_RS05175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS05180	COG4558	Periplasmic binding protein
C2D60_RS05185	COG3720	iron ion transport
C2D60_RS05205	COG0679	Auxin Efflux Carrier
C2D60_RS05220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D60_RS05225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D60_RS05230	COG1121	(ABC) transporter
C2D60_RS05240	COG1609	Transcriptional regulator
C2D60_RS05245	COG1940	carbohydrate kinase activity
C2D60_RS05250	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D60_RS05255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS05260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS05265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS05275	COG4580	involved in the transport of maltose and maltodextrins
C2D60_RS05285	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS05295	COG0309	Hydrogenase expression formation protein (HypE)
C2D60_RS05300	COG0409	Hydrogenase expression formation protein
C2D60_RS05305	COG0298	carbon dioxide binding
C2D60_RS05310	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2D60_RS05330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D60_RS05335	COG0651	ATP synthesis coupled electron transport
C2D60_RS05340	COG0650	Formate hydrogenlyase subunit 4
C2D60_RS05345	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2D60_RS05345	COG3261	NADH dehydrogenase
C2D60_RS05350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D60_RS05355	COG3260	NADH ubiquinone oxidoreductase 20
C2D60_RS05365	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2D60_RS05375	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS05380	COG1263	PTS System
C2D60_RS05380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS05385	COG1609	Transcriptional regulator
C2D60_RS05390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D60_RS05395	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2D60_RS05400	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D60_RS05430	COG1349	DNA-binding transcription factor activity
C2D60_RS05435	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS05450	COG3732	PTS system glucitol sorbitol-specific
C2D60_RS05455	COG3730	PTS system glucitol sorbitol-specific
C2D60_RS05460	COG2951	lytic endotransglycosylase activity
C2D60_RS05475	COG1121	(ABC) transporter
C2D60_RS05480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D60_RS05490	COG1546	Belongs to the CinA family
C2D60_RS05515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2D60_RS05545	COG2823	Periplasmic or secreted lipoprotein
C2D60_RS05550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D60_RS05555	COG1238	metal cluster binding
C2D60_RS05575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2D60_RS05580	COG2814	Major facilitator Superfamily
C2D60_RS05585	COG1566	PFAM secretion protein HlyD family protein
C2D60_RS05590	COG1846	Transcriptional regulator
C2D60_RS05600	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2D60_RS05610	COG4176	ABC-type proline glycine betaine transport system permease component
C2D60_RS05625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2D60_RS05635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2D60_RS05640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D60_RS05645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D60_RS05650	COG4575	ribosome binding
C2D60_RS05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS05680	COG3708	Transcriptional regulator
C2D60_RS05680	COG2207	Transcriptional regulator
C2D60_RS05715	COG0582	viral genome integration into host DNA
C2D60_RS05785	COG1484	DNA-dependent DNA replication
C2D60_RS05790	COG0305	Participates in initiation and elongation during chromosome replication
C2D60_RS05795	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2D60_RS05820	COG3179	chitinase
C2D60_RS05860	COG1802	Transcriptional regulator
C2D60_RS05860	COG4626	Terminase
C2D60_RS05965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2D60_RS05995	COG2867	negative regulation of translational initiation
C2D60_RS06010	COG0497	DNA recombination
C2D60_RS06030	COG4536	flavin adenine dinucleotide binding
C2D60_RS06035	COG4137	Cytochrome C assembly protein
C2D60_RS06040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2D60_RS06075	COG2885	chlorophyll binding
C2D60_RS06080	COG2199	diguanylate cyclase activity
C2D60_RS06090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D60_RS06095	COG1605	Chorismate mutase
C2D60_RS06095	COG0287	Prephenate dehydrogenase
C2D60_RS06105	COG0077	Prephenate dehydratase
C2D60_RS06105	COG1605	Chorismate mutase
C2D60_RS06115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2D60_RS06120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D60_RS06135	COG0542	response to heat
C2D60_RS06160	COG0477	Major facilitator Superfamily
C2D60_RS06165	COG5544	Lipoprotein
C2D60_RS06170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2D60_RS06180	COG3148	PFAM DTW domain containing protein
C2D60_RS06185	COG3118	belongs to the thioredoxin family
C2D60_RS06190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D60_RS06205	COG0513	Belongs to the DEAD box helicase family
C2D60_RS06215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2D60_RS06230	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2D60_RS06235	COG3026	antisigma factor binding
C2D60_RS06240	COG3086	response to oxidative stress
C2D60_RS06250	COG0681	Belongs to the peptidase S26 family
C2D60_RS06270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2D60_RS06280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D60_RS06285	COG1737	Transcriptional regulator
C2D60_RS06290	COG0560	Phosphoserine phosphatase
C2D60_RS06305	COG0047	phosphoribosylformylglycinamidine synthase activity
C2D60_RS06305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2D60_RS06310	COG2205	protein histidine kinase activity
C2D60_RS06315	COG3170	Tfp pilus assembly protein FimV
C2D60_RS06320	COG2204	response regulator
C2D60_RS06325	COG0347	Belongs to the P(II) protein family
C2D60_RS06330	COG1017	nitric oxide dioxygenase activity
C2D60_RS06330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D60_RS06340	COG2259	Doxx family
C2D60_RS06350	COG0457	Tetratricopeptide repeat
C2D60_RS06355	COG2814	Major facilitator Superfamily
C2D60_RS06355	COG0477	Major facilitator Superfamily
C2D60_RS06360	COG2017	converts alpha-aldose to the beta-anomer
C2D60_RS06365	COG2814	Major facilitator Superfamily
C2D60_RS06370	COG3711	transcriptional antiterminator
C2D60_RS06375	COG3683	transport system, periplasmic component
C2D60_RS06380	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D60_RS06410	COG0822	iron-sulfur transferase activity
C2D60_RS06430	COG0633	Ferredoxin
C2D60_RS06435	COG2975	iron-sulfur cluster assembly
C2D60_RS06455	COG2897	thiosulfate sulfurtransferase activity
C2D60_RS06460	COG2373	Large extracellular alpha-helical protein
C2D60_RS06465	COG4953	penicillin-binding protein 1C
C2D60_RS06500	COG2976	Protein conserved in bacteria
C2D60_RS06520	COG1645	bacterial-type flagellum-dependent swarming motility
C2D60_RS06530	COG0517	IMP dehydrogenase activity
C2D60_RS06530	COG0516	GMP reductase activity
C2D60_RS06575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D60_RS06605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2D60_RS06610	COG3756	Protein conserved in bacteria
C2D60_RS06670	COG5484	DNA packaging
C2D60_RS06670	COG3728	DNA packaging
C2D60_RS06820	COG3119	arylsulfatase activity
C2D60_RS06825	COG0641	radical SAM
C2D60_RS06845	COG2200	EAL domain
C2D60_RS06860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2D60_RS06875	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS06885	COG2233	PERMEase
C2D60_RS06900	COG1393	Belongs to the ArsC family
C2D60_RS06905	COG4783	chaperone-mediated protein folding
C2D60_RS06910	COG0628	permease
C2D60_RS06915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2D60_RS06920	COG2716	regulation of RNA biosynthetic process
C2D60_RS06930	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2D60_RS06940	COG2321	neutral zinc metallopeptidase
C2D60_RS06945	COG1444	tRNA N-acetyltransferase activity
C2D60_RS06950	COG0400	carboxylic ester hydrolase activity
C2D60_RS06965	COG1393	Belongs to the ArsC family
C2D60_RS06975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D60_RS06985	COG0493	'glutamate synthase
C2D60_RS06985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D60_RS06995	COG5342	invasion associated locus B
C2D60_RS07000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D60_RS07005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D60_RS07015	COG4810	utilization protein
C2D60_RS07105	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D60_RS07125	COG2837	iron assimilation
C2D60_RS07135	COG4150	thiosulfate binding
C2D60_RS07140	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2D60_RS07145	COG4208	sulfate ABC transporter
C2D60_RS07150	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2D60_RS07160	COG4319	ketosteroid isomerase
C2D60_RS07195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2D60_RS07215	COG3530	Putative quorum-sensing-regulated virulence factor
C2D60_RS07220	COG0385	Bile acid
C2D60_RS07225	COG0583	DNA-binding transcription factor activity
C2D60_RS07265	COG3415	Transposase
C2D60_RS07270	COG3415	Transposase
C2D60_RS07285	COG2200	EAL domain
C2D60_RS07285	COG2199	diguanylate cyclase activity
C2D60_RS07290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D60_RS07305	COG0667	Aldo Keto reductase
C2D60_RS07310	COG3961	Belongs to the TPP enzyme family
C2D60_RS07325	COG3279	Response regulator of the LytR AlgR family
C2D60_RS07330	COG3275	phosphorelay sensor kinase activity
C2D60_RS07340	COG0436	Aminotransferase
C2D60_RS07350	COG2807	transmembrane transport
C2D60_RS07355	COG0590	tRNA wobble adenosine to inosine editing
C2D60_RS07360	COG0583	DNA-binding transcription factor activity
C2D60_RS07380	COG2116	formate transmembrane transporter activity
C2D60_RS07385	COG2853	Lipoprotein
C2D60_RS07395	COG3691	Protein conserved in bacteria
C2D60_RS07410	COG2062	phosphohistidine phosphatase, SixA
C2D60_RS07435	COG0730	response to heat
C2D60_RS07440	COG3101	peptidyl-lysine hydroxylation
C2D60_RS07455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D60_RS07475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D60_RS07485	COG0586	Pfam SNARE associated Golgi protein
C2D60_RS07495	COG0285	dihydrofolate synthase activity
C2D60_RS07500	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2D60_RS07505	COG1286	toxin biosynthetic process
C2D60_RS07510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2D60_RS07515	COG0163	prenyltransferase activity
C2D60_RS07535	COG4160	amino acid transport
C2D60_RS07540	COG4598	ABC transporter
C2D60_RS07550	COG1090	epimerase
C2D60_RS07555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2D60_RS07560	COG0625	glutathione transferase activity
C2D60_RS07565	COG0625	glutathione transferase activity
C2D60_RS07570	COG0622	Phosphoesterase
C2D60_RS07575	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2D60_RS07580	COG0280	phosphate acetyltransferase
C2D60_RS07580	COG0857	belongs to the CobB CobQ family
C2D60_RS07600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D60_RS07605	COG0471	metal ion transport
C2D60_RS07605	COG0490	domain, Protein
C2D60_RS07615	COG0436	Aminotransferase
C2D60_RS07620	COG0583	DNA-binding transcription factor activity
C2D60_RS07670	COG0839	Belongs to the complex I subunit 6 family
C2D60_RS07680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2D60_RS07685	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D60_RS07700	COG2153	protein acetylation
C2D60_RS07705	COG1169	isochorismate synthase
C2D60_RS07730	COG0318	PFAM AMP-dependent synthetase and ligase
C2D60_RS07740	COG5464	transposase or invertase
C2D60_RS07755	COG1414	Transcriptional regulator
C2D60_RS07765	COG2271	Major facilitator Superfamily
C2D60_RS07775	COG0247	lactate metabolic process
C2D60_RS07785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2D60_RS07790	COG2271	Major facilitator Superfamily
C2D60_RS07795	COG0584	glycerophosphoryl diester phosphodiesterase
C2D60_RS07805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D60_RS07835	COG0784	Response regulator, receiver
C2D60_RS07835	COG2205	protein histidine kinase activity
C2D60_RS07845	COG2198	Histidine kinase
C2D60_RS07845	COG0642	Histidine kinase
C2D60_RS07860	COG2169	Transcriptional regulator
C2D60_RS07860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2D60_RS07865	COG3145	DNA-N1-methyladenine dioxygenase activity
C2D60_RS07870	COG4615	Cyclic peptide transporter
C2D60_RS07875	COG2239	Acts as a magnesium transporter
C2D60_RS07880	COG0659	secondary active sulfate transmembrane transporter activity
C2D60_RS07895	COG0628	permease
C2D60_RS07920	COG1349	DNA-binding transcription factor activity
C2D60_RS07925	COG0494	nUDIX hydrolase
C2D60_RS07945	COG1061	Type III restriction enzyme res subunit
C2D60_RS07950	COG1187	pseudouridine synthase activity
C2D60_RS07955	COG2814	Major facilitator Superfamily
C2D60_RS07965	COG4172	Belongs to the ABC transporter superfamily
C2D60_RS07970	COG4239	(ABC) transporter, permease
C2D60_RS07975	COG4174	ABC transporter (Permease)
C2D60_RS07980	COG4166	transmembrane transport
C2D60_RS07985	COG2200	EAL domain
C2D60_RS07990	COG0791	NLP P60 protein
C2D60_RS07995	COG0671	phosphoesterase, PA-phosphatase related
C2D60_RS08000	COG0523	cobalamin synthesis protein
C2D60_RS08005	COG0246	Mannitol dehydrogenase
C2D60_RS08010	COG1312	Catalyzes the dehydration of D-mannonate
C2D60_RS08025	COG2814	Major facilitator Superfamily
C2D60_RS08035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS08035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS08040	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D60_RS08045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS08045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS08045	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2D60_RS08055	COG2855	membrane
C2D60_RS08065	COG0583	DNA-binding transcription factor activity
C2D60_RS08070	COG0833	amino acid
C2D60_RS08085	COG4771	TonB-dependent receptor
C2D60_RS08100	COG2311	Membrane
C2D60_RS08115	COG1129	ABC transporter
C2D60_RS08125	COG2949	membrane
C2D60_RS08140	COG1346	cytolysis
C2D60_RS08150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2D60_RS08155	COG3659	wide pore channel activity
C2D60_RS08170	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS08175	COG1538	Outer membrane efflux protein
C2D60_RS08180	COG0586	Pfam SNARE associated Golgi protein
C2D60_RS08190	COG1686	Belongs to the peptidase S11 family
C2D60_RS08200	COG0277	FAD linked oxidase domain protein
C2D60_RS08205	COG1472	Belongs to the glycosyl hydrolase 3 family
C2D60_RS08210	COG1732	Glycine betaine
C2D60_RS08215	COG1174	glycine betaine transport
C2D60_RS08220	COG1125	glycine betaine transport
C2D60_RS08225	COG1174	glycine betaine transport
C2D60_RS08235	COG3275	phosphorelay sensor kinase activity
C2D60_RS08245	COG4807	Protein conserved in bacteria
C2D60_RS08265	COG5455	response to cobalt ion
C2D60_RS08270	COG0583	DNA-binding transcription factor activity
C2D60_RS08275	COG2252	PERMEase
C2D60_RS08285	COG0583	DNA-binding transcription factor activity
C2D60_RS08290	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C2D60_RS08325	COG0351	phosphomethylpyrimidine kinase
C2D60_RS08330	COG1830	Aldolase
C2D60_RS08365	COG1070	Carbohydrate kinase
C2D60_RS08375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D60_RS08380	COG4948	Mandelate Racemase Muconate Lactonizing
C2D60_RS08385	COG0747	negative chemotaxis
C2D60_RS08390	COG0601	transmembrane transport
C2D60_RS08395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D60_RS08400	COG0444	Belongs to the ABC transporter superfamily
C2D60_RS08405	COG4608	Belongs to the ABC transporter superfamily
C2D60_RS08415	COG0826	peptidase U32
C2D60_RS08420	COG0745	RESPONSE REGULATOR receiver
C2D60_RS08425	COG2205	protein histidine kinase activity
C2D60_RS08450	COG1301	dicarboxylic acid transport
C2D60_RS08465	COG5002	protein histidine kinase activity
C2D60_RS08470	COG0443	Heat shock 70 kDa protein
C2D60_RS08475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2D60_RS08490	COG2982	Protein involved in outer membrane biogenesis
C2D60_RS08495	COG1253	flavin adenine dinucleotide binding
C2D60_RS08550	COG0110	maltose O-acetyltransferase activity
C2D60_RS08555	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2D60_RS08560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D60_RS08565	COG1051	belongs to the nudix hydrolase family
C2D60_RS08570	COG0297	glycogen (starch) synthase activity
C2D60_RS08640	COG0438	transferase activity, transferring glycosyl groups
C2D60_RS08645	COG1442	glycosyl transferase family 8
C2D60_RS08645	COG1216	Glycosyl transferase, family 2
C2D60_RS08655	COG0463	Glycosyl transferase, family 2
C2D60_RS08680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2D60_RS08710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D60_RS08715	COG0583	DNA-binding transcription factor activity
C2D60_RS08725	COG0531	amino acid
C2D60_RS08730	COG0640	Transcriptional regulator
C2D60_RS08735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2D60_RS08740	COG2925	Exonuclease
C2D60_RS08755	COG1289	transmembrane transporter activity
C2D60_RS08775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2D60_RS08785	COG1942	4-Oxalocrotonate Tautomerase
C2D60_RS08790	COG0583	DNA-binding transcription factor activity
C2D60_RS08795	COG0095	Lipoate-protein ligase
C2D60_RS08800	COG0477	Major facilitator Superfamily
C2D60_RS08815	COG5001	Diguanylate cyclase
C2D60_RS08815	COG3300	MHYT domain
C2D60_RS08820	COG3615	Tellurite resistance protein tehB
C2D60_RS08845	COG3706	GGDEF domain
C2D60_RS08885	COG2197	response regulator
C2D60_RS08930	COG0154	amidase activity
C2D60_RS08955	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2D60_RS08985	COG4771	TonB-dependent receptor
C2D60_RS08990	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2D60_RS09010	COG2226	methyltransferase
C2D60_RS09010	COG3433	isochorismatase activity
C2D60_RS09010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2D60_RS09025	COG1132	(ABC) transporter
C2D60_RS09030	COG2814	Major facilitator Superfamily
C2D60_RS09035	COG1169	isochorismate synthase
C2D60_RS09040	COG0582	viral genome integration into host DNA
C2D60_RS09060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS09065	COG0735	belongs to the Fur family
C2D60_RS09075	COG0523	cobalamin synthesis protein
C2D60_RS09105	COG0523	cobalamin synthesis protein
C2D60_RS09145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D60_RS09150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D60_RS09155	COG1121	(ABC) transporter
C2D60_RS09160	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2D60_RS09165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2D60_RS09175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2D60_RS09215	COG2264	protein methyltransferase activity
C2D60_RS09250	COG2994	toxin metabolic process
C2D60_RS09295	COG0582	viral genome integration into host DNA
C2D60_RS09305	COG0534	Mate efflux family protein
C2D60_RS09315	COG0582	viral genome integration into host DNA
C2D60_RS09325	COG1121	(ABC) transporter
C2D60_RS09330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D60_RS09335	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2D60_RS09365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2D60_RS09385	COG0604	alcohol dehydrogenase
C2D60_RS09390	COG1309	transcriptional regulator
C2D60_RS09395	COG0025	NhaP-type Na H and K H
C2D60_RS09415	COG1376	ErfK ybiS ycfS ynhG family protein
C2D60_RS09430	COG0251	oxidation-reduction process
C2D60_RS09460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D60_RS09475	COG1418	mRNA catabolic process
C2D60_RS09480	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2D60_RS09485	COG3727	T/G mismatch-specific endonuclease activity
C2D60_RS09490	COG0697	spore germination
C2D60_RS09495	COG2354	Protein conserved in bacteria
C2D60_RS09525	COG0366	Alpha amylase catalytic
C2D60_RS09530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS09540	COG0765	amino acid transport
C2D60_RS09545	COG1126	abc transporter atp-binding protein
C2D60_RS09550	COG2197	response regulator
C2D60_RS09560	COG2197	response regulator
C2D60_RS09595	COG3012	SEC-C Motif Domain Protein
C2D60_RS09595	COG3318	Belongs to the UPF0149 family
C2D60_RS09600	COG0814	amino acid
C2D60_RS09610	COG1528	Iron-storage protein
C2D60_RS09625	COG0477	Major facilitator Superfamily
C2D60_RS09635	COG2211	Major facilitator Superfamily
C2D60_RS09645	COG1528	Iron-storage protein
C2D60_RS09655	COG1879	ABC-type sugar transport system periplasmic component
C2D60_RS09665	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS09690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2D60_RS09700	COG3102	Protein conserved in bacteria
C2D60_RS09720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2D60_RS09725	COG1801	Protein of unknown function DUF72
C2D60_RS09730	COG1335	isochorismatase
C2D60_RS09740	COG0494	nUDIX hydrolase
C2D60_RS09765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D60_RS09775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2D60_RS09780	COG0739	heme binding
C2D60_RS09785	COG1560	Kdo2-lipid A biosynthetic process
C2D60_RS09795	COG1737	Transcriptional regulator
C2D60_RS09810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2D60_RS09815	COG0129	dihydroxy-acid dehydratase activity
C2D60_RS09820	COG0800	Aldolase
C2D60_RS09830	COG3141	response to X-ray
C2D60_RS09835	COG2979	Protein of unknown function (DUF533)
C2D60_RS09840	COG1770	oligopeptidase
C2D60_RS09845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D60_RS09855	COG2372	response to copper ion
C2D60_RS09860	COG1276	copper resistance
C2D60_RS09875	COG2990	Protein conserved in bacteria
C2D60_RS09900	COG3008	intermembrane lipid transfer
C2D60_RS09905	COG2995	paraquat-inducible protein a
C2D60_RS09910	COG1956	GAF domain-containing protein
C2D60_RS09930	COG2814	Major facilitator Superfamily
C2D60_RS09940	COG1414	Transcriptional regulator
C2D60_RS09980	COG0768	penicillin binding
C2D60_RS09985	COG2226	methyltransferase
C2D60_RS10000	COG3716	PTS system mannose fructose sorbose family IID component
C2D60_RS10005	COG3715	PTS system
C2D60_RS10010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS10010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS10015	COG1253	flavin adenine dinucleotide binding
C2D60_RS10020	COG2200	EAL domain
C2D60_RS10025	COG1760	l-serine dehydratase
C2D60_RS10045	COG0251	oxidation-reduction process
C2D60_RS10050	COG1199	ATP-dependent helicase activity
C2D60_RS10060	COG3065	identical protein binding
C2D60_RS10070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2D60_RS10080	COG2894	cell division
C2D60_RS10095	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2D60_RS10125	COG2719	SpoVR family
C2D60_RS10145	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2D60_RS10155	COG4774	siderophore transport
C2D60_RS10170	COG2308	Evidence 4 Homologs of previously reported genes of
C2D60_RS10245	COG0012	GTP binding
C2D60_RS10265	COG0659	secondary active sulfate transmembrane transporter activity
C2D60_RS10295	COG2890	protein-(glutamine-N5) methyltransferase activity
C2D60_RS10315	COG0387	Pfam Sodium calcium exchanger
C2D60_RS10320	COG4572	Cation transport regulator
C2D60_RS10325	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2D60_RS10335	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2D60_RS10340	COG3707	response regulator
C2D60_RS10345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D60_RS10355	COG1116	anion transmembrane transporter activity
C2D60_RS10360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2D60_RS10360	COG2146	nitrite reductase [NAD(P)H] activity
C2D60_RS10365	COG0243	molybdopterin cofactor binding
C2D60_RS10370	COG4932	domain protein
C2D60_RS10375	COG2197	response regulator
C2D60_RS10380	COG3850	Histidine kinase
C2D60_RS10385	COG2223	nitrite transmembrane transporter activity
C2D60_RS10390	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2D60_RS10395	COG1140	nitrate reductase beta subunit
C2D60_RS10400	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2D60_RS10405	COG2181	nitrate reductase activity
C2D60_RS10415	COG1522	sequence-specific DNA binding
C2D60_RS10450	COG0788	formyltetrahydrofolate deformylase activity
C2D60_RS10460	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2D60_RS10465	COG0745	RESPONSE REGULATOR receiver
C2D60_RS10470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2D60_RS10475	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D60_RS10480	COG1435	thymidine kinase activity
C2D60_RS10485	COG1454	alcohol dehydrogenase
C2D60_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS10495	COG2095	MarC family integral membrane protein
C2D60_RS10500	COG4166	transmembrane transport
C2D60_RS10505	COG0601	transmembrane transport
C2D60_RS10510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D60_RS10515	COG0444	Belongs to the ABC transporter superfamily
C2D60_RS10525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2D60_RS10545	COG2353	YceI-like domain
C2D60_RS10550	COG2350	Protein conserved in bacteria
C2D60_RS10560	COG3001	Fructosamine kinase
C2D60_RS10570	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D60_RS10575	COG3137	Salt-induced outer membrane protein
C2D60_RS10620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2D60_RS10620	COG0072	phenylalanine-tRNA ligase activity
C2D60_RS10640	COG0583	DNA-binding transcription factor activity
C2D60_RS10660	COG0386	Belongs to the glutathione peroxidase family
C2D60_RS10670	COG0791	NLP P60 protein
C2D60_RS10680	COG4256	Hemin uptake protein
C2D60_RS10685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D60_RS10695	COG0574	Belongs to the PEP-utilizing enzyme family
C2D60_RS10695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2D60_RS10705	COG0628	permease
C2D60_RS10710	COG0277	FAD linked oxidase domain protein
C2D60_RS10710	COG0247	lactate metabolic process
C2D60_RS10715	COG2050	protein possibly involved in aromatic compounds catabolism
C2D60_RS10720	COG2261	transglycosylase associated protein
C2D60_RS10750	COG1120	ATPase activity
C2D60_RS10755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS10765	COG0583	DNA-binding transcription factor activity
C2D60_RS10790	COG1304	FMN binding
C2D60_RS10795	COG1309	transcriptional regulator
C2D60_RS10810	COG0316	Belongs to the HesB IscA family
C2D60_RS10815	COG0719	Fe-S assembly protein
C2D60_RS10820	COG0396	ATPase activity
C2D60_RS10825	COG0719	Fe-S assembly protein
C2D60_RS10840	COG1376	ErfK ybiS ycfS ynhG family protein
C2D60_RS10865	COG1309	transcriptional regulator
C2D60_RS10870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2D60_RS10870	COG1082	Xylose isomerase domain protein TIM barrel
C2D60_RS10875	COG2271	Major facilitator Superfamily
C2D60_RS10880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2D60_RS10890	COG1120	ATPase activity
C2D60_RS10895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS10900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2D60_RS10905	COG1414	Transcriptional regulator
C2D60_RS10940	COG2814	Major facilitator Superfamily
C2D60_RS10960	COG0583	DNA-binding transcription factor activity
C2D60_RS10965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D60_RS10985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D60_RS10990	COG1116	anion transmembrane transporter activity
C2D60_RS10995	COG4774	siderophore transport
C2D60_RS11000	COG1120	ATPase activity
C2D60_RS11005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS11010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS11030	COG0765	amino acid transport
C2D60_RS11035	COG1126	abc transporter atp-binding protein
C2D60_RS11065	COG1473	amidohydrolase
C2D60_RS11070	COG3383	formate dehydrogenase (NAD+) activity
C2D60_RS11075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2D60_RS11090	COG1175	transmembrane transport
C2D60_RS11125	COG1857	crispr-associated protein
C2D60_RS11135	COG1518	maintenance of DNA repeat elements
C2D60_RS11140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D60_RS11145	COG3157	Type VI secretion system effector, Hcp
C2D60_RS11180	COG4133	protoheme IX ABC transporter activity
C2D60_RS11185	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2D60_RS11190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2D60_RS11205	COG1138	Cytochrome C-type biogenesis protein
C2D60_RS11210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2D60_RS11215	COG3088	subunit of a heme lyase
C2D60_RS11215	COG4235	cytochrome complex assembly
C2D60_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS11280	COG2610	gluconate transmembrane transporter activity
C2D60_RS11285	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2D60_RS11295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2D60_RS11305	COG0583	DNA-binding transcription factor activity
C2D60_RS11330	COG0277	FAD linked oxidase domain protein
C2D60_RS11335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D60_RS11360	COG0402	S-adenosylhomocysteine deaminase activity
C2D60_RS11420	COG4608	Belongs to the ABC transporter superfamily
C2D60_RS11425	COG0444	Belongs to the ABC transporter superfamily
C2D60_RS11450	COG0346	lactoylglutathione lyase activity
C2D60_RS11455	COG1349	DNA-binding transcription factor activity
C2D60_RS11485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2D60_RS11505	COG0300	oxidoreductase activity
C2D60_RS11555	COG0307	riboflavin synthase, alpha
C2D60_RS11560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2D60_RS11565	COG2814	Major facilitator Superfamily
C2D60_RS11570	COG0583	DNA-binding transcription factor activity
C2D60_RS11585	COG2814	Major facilitator Superfamily
C2D60_RS11600	COG0791	NLP P60 protein
C2D60_RS11605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2D60_RS11615	COG0346	lactoylglutathione lyase activity
C2D60_RS11620	COG1902	pentaerythritol trinitrate reductase activity
C2D60_RS11625	COG1309	transcriptional regulator
C2D60_RS11630	COG3313	Fe-S protein
C2D60_RS11635	COG4989	oxidoreductase activity
C2D60_RS11640	COG2032	superoxide dismutase activity
C2D60_RS11645	COG1289	transmembrane transporter activity
C2D60_RS11650	COG1566	PFAM secretion protein HlyD family protein
C2D60_RS11665	COG3706	GGDEF domain
C2D60_RS11680	COG3895	Periplasmic Protein
C2D60_RS11695	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2D60_RS11700	COG0625	glutathione transferase activity
C2D60_RS11715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2D60_RS11725	COG4659	FMN binding
C2D60_RS11760	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS11770	COG0673	inositol 2-dehydrogenase activity
C2D60_RS11780	COG2814	Major facilitator Superfamily
C2D60_RS11800	COG3038	cytochrome b561
C2D60_RS11820	COG0583	DNA-binding transcription factor activity
C2D60_RS11825	COG3485	protocatechuate 3,4-dioxygenase
C2D60_RS11830	COG3485	protocatechuate 3,4-dioxygenase
C2D60_RS11835	COG5383	Protein conserved in bacteria
C2D60_RS11840	COG2272	Belongs to the type-B carboxylesterase lipase family
C2D60_RS11865	COG2814	Major facilitator Superfamily
C2D60_RS11875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D60_RS11885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D60_RS11895	COG0747	negative chemotaxis
C2D60_RS11900	COG1064	alcohol dehydrogenase
C2D60_RS11915	COG0488	(ABC) transporter
C2D60_RS11950	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS11955	COG3729	General stress protein
C2D60_RS11975	COG3685	Protein conserved in bacteria
C2D60_RS11985	COG0366	Alpha amylase catalytic
C2D60_RS11995	COG2323	membrane
C2D60_RS12005	COG3111	PFAM Bacterial OB fold (BOF) protein
C2D60_RS12010	COG1764	response to oxidative stress
C2D60_RS12035	COG3781	membrane
C2D60_RS12040	COG0243	molybdopterin cofactor binding
C2D60_RS12045	COG0583	DNA-binding transcription factor activity
C2D60_RS12075	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS12080	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D60_RS12085	COG2814	Major facilitator Superfamily
C2D60_RS12095	COG1285	pathogenesis
C2D60_RS12100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2D60_RS12110	COG0583	DNA-binding transcription factor activity
C2D60_RS12130	COG0519	Catalyzes the synthesis of GMP from XMP
C2D60_RS12130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2D60_RS12170	COG0596	Alpha beta hydrolase
C2D60_RS12180	COG2205	protein histidine kinase activity
C2D60_RS12195	COG0076	glutamate decarboxylase activity
C2D60_RS12200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D60_RS12205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D60_RS12210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D60_RS12215	COG1116	anion transmembrane transporter activity
C2D60_RS12220	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2D60_RS12235	COG0673	inositol 2-dehydrogenase activity
C2D60_RS12245	COG1609	Transcriptional regulator
C2D60_RS12250	COG3706	GGDEF domain
C2D60_RS12255	COG0402	S-adenosylhomocysteine deaminase activity
C2D60_RS12260	COG1953	Uracil, thiamine, allantoin
C2D60_RS12295	COG0596	Alpha beta hydrolase
C2D60_RS12310	COG2207	Transcriptional regulator
C2D60_RS12345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D60_RS12390	COG0765	amino acid transport
C2D60_RS12400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2D60_RS12410	COG2070	2-Nitropropane dioxygenase
C2D60_RS12415	COG0583	DNA-binding transcription factor activity
C2D60_RS12425	COG1902	pentaerythritol trinitrate reductase activity
C2D60_RS12430	COG4529	Protein conserved in bacteria
C2D60_RS12435	COG0477	Major facilitator Superfamily
C2D60_RS12465	COG2223	nitrite transmembrane transporter activity
C2D60_RS12475	COG1609	Transcriptional regulator
C2D60_RS12480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS12490	COG3037	sugar-specific permease SgaT UlaA
C2D60_RS12495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D60_RS12505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS12525	COG0583	DNA-binding transcription factor activity
C2D60_RS12530	COG0583	DNA-binding transcription factor activity
C2D60_RS12535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2D60_RS12545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2D60_RS12560	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS12570	COG1609	Transcriptional regulator
C2D60_RS12600	COG1652	LysM domain
C2D60_RS12625	COG0456	acetyltransferase
C2D60_RS12625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2D60_RS12635	COG0667	Aldo Keto reductase
C2D60_RS12640	COG0667	Aldo Keto reductase
C2D60_RS12655	COG1349	DNA-binding transcription factor activity
C2D60_RS12670	COG1349	DNA-binding transcription factor activity
C2D60_RS12675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D60_RS12680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D60_RS12685	COG0738	Major facilitator superfamily
C2D60_RS12730	COG1929	Belongs to the glycerate kinase type-1 family
C2D60_RS12735	COG3835	regulator
C2D60_RS12755	COG2186	Transcriptional regulator
C2D60_RS12760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS12760	COG1263	PTS System
C2D60_RS12770	COG2814	Major facilitator Superfamily
C2D60_RS12775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS12775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS12785	COG2819	hydrolase of the alpha beta superfamily
C2D60_RS12790	COG5001	Diguanylate cyclase
C2D60_RS12790	COG3300	MHYT domain
C2D60_RS12825	COG3188	usher protein
C2D60_RS12840	COG1649	PFAM Uncharacterised BCR, COG1649
C2D60_RS12845	COG3550	peptidyl-serine autophosphorylation
C2D60_RS12850	COG1396	sequence-specific DNA binding
C2D60_RS12855	COG2351	hydroxyisourate hydrolase activity
C2D60_RS12860	COG3195	allantoin biosynthetic process
C2D60_RS12860	COG3648	Uricase
C2D60_RS12865	COG2233	PERMEase
C2D60_RS12895	COG2207	Transcriptional regulator
C2D60_RS12930	COG2011	ABC-type metal ion transport system permease component
C2D60_RS12935	COG2070	2-Nitropropane dioxygenase
C2D60_RS12945	COG0477	Major facilitator Superfamily
C2D60_RS13025	COG2199	diguanylate cyclase activity
C2D60_RS13040	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS13045	COG0583	DNA-binding transcription factor activity
C2D60_RS13055	COG0039	L-malate dehydrogenase activity
C2D60_RS13060	COG1349	DNA-binding transcription factor activity
C2D60_RS13065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2D60_RS13070	COG3395	kinase activity
C2D60_RS13080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2D60_RS13085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D60_RS13090	COG2271	Major facilitator Superfamily
C2D60_RS13115	COG4977	sequence-specific DNA binding
C2D60_RS13125	COG0697	spore germination
C2D60_RS13130	COG2814	Major facilitator Superfamily
C2D60_RS13145	COG1129	ABC transporter
C2D60_RS13165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2D60_RS13200	COG2223	nitrite transmembrane transporter activity
C2D60_RS13205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2D60_RS13220	COG1349	DNA-binding transcription factor activity
C2D60_RS13225	COG2084	Dehydrogenase
C2D60_RS13230	COG3395	kinase activity
C2D60_RS13235	COG0235	Class ii aldolase
C2D60_RS13240	COG3622	Belongs to the hyi family
C2D60_RS13245	COG2610	gluconate transmembrane transporter activity
C2D60_RS13250	COG3708	Transcriptional regulator
C2D60_RS13250	COG2207	Transcriptional regulator
C2D60_RS13265	COG2200	EAL domain
C2D60_RS13270	COG1546	Belongs to the CinA family
C2D60_RS13275	COG0071	Belongs to the small heat shock protein (HSP20) family
C2D60_RS13290	COG2197	response regulator
C2D60_RS13295	COG2135	peptidase activity
C2D60_RS13300	COG2207	Transcriptional regulator
C2D60_RS13315	COG4221	oxidoreductase activity
C2D60_RS13320	COG1802	Transcriptional regulator
C2D60_RS13325	COG0589	response to stress
C2D60_RS13330	COG0246	Mannitol dehydrogenase
C2D60_RS13335	COG2271	Major facilitator Superfamily
C2D60_RS13350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D60_RS13365	COG0243	molybdopterin cofactor binding
C2D60_RS13370	COG0437	4 iron, 4 sulfur cluster binding
C2D60_RS13375	COG3302	dmso reductase anchor subunit
C2D60_RS13390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2D60_RS13395	COG1940	carbohydrate kinase activity
C2D60_RS13400	COG0583	DNA-binding transcription factor activity
C2D60_RS13405	COG2814	Major facilitator Superfamily
C2D60_RS13410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2D60_RS13420	COG3591	Belongs to the peptidase S1B family
C2D60_RS13440	COG0628	permease
C2D60_RS13470	COG0679	Auxin Efflux Carrier
C2D60_RS13480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2D60_RS13505	COG3290	protein histidine kinase activity
C2D60_RS13510	COG4565	transcriptional regulatory protein
C2D60_RS13535	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D60_RS13535	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D60_RS13550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D60_RS13555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2D60_RS13565	COG0183	Belongs to the thiolase family
C2D60_RS13570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2D60_RS13580	COG1414	Transcriptional regulator
C2D60_RS13585	COG2840	Smr protein MutS2
C2D60_RS13590	COG0583	DNA-binding transcription factor activity
C2D60_RS13600	COG1473	amidohydrolase
C2D60_RS13605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2D60_RS13620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2D60_RS13635	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2D60_RS13640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2D60_RS13660	COG0531	amino acid
C2D60_RS13670	COG3136	membrane protein required for alginate biosynthesis
C2D60_RS13675	COG0745	RESPONSE REGULATOR receiver
C2D60_RS13685	COG2205	protein histidine kinase activity
C2D60_RS13695	COG0114	fumarate hydratase activity
C2D60_RS13700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D60_RS13700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D60_RS13705	COG1482	cell wall glycoprotein biosynthetic process
C2D60_RS13710	COG5339	Protein conserved in bacteria
C2D60_RS13715	COG1609	Transcriptional regulator
C2D60_RS13720	COG1263	PTS System
C2D60_RS13720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS13725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2D60_RS13750	COG2391	methyltransferase activity
C2D60_RS13755	COG0425	Belongs to the sulfur carrier protein TusA family
C2D60_RS13760	COG5562	phage envelope protein
C2D60_RS13765	COG0401	homolog of Blt101
C2D60_RS13770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2D60_RS13775	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS13780	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2D60_RS13785	COG0477	Major facilitator Superfamily
C2D60_RS13790	COG1113	amino acid transport
C2D60_RS13795	COG2988	succinylglutamate desuccinylase activity
C2D60_RS13800	COG3724	N-succinylarginine dihydrolase activity
C2D60_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS13810	COG3138	arginine N-succinyltransferase
C2D60_RS13815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2D60_RS13820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2D60_RS13825	COG0667	Aldo Keto reductase
C2D60_RS13830	COG0583	DNA-binding transcription factor activity
C2D60_RS13855	COG4122	O-methyltransferase activity
C2D60_RS13860	COG1643	Atp-dependent helicase
C2D60_RS13875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D60_RS13880	COG3327	negative regulation of DNA-templated transcription, initiation
C2D60_RS13885	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2D60_RS13890	COG0183	Belongs to the thiolase family
C2D60_RS13895	COG2050	protein possibly involved in aromatic compounds catabolism
C2D60_RS13900	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2D60_RS13905	COG1024	Enoyl-CoA hydratase
C2D60_RS13910	COG1024	Enoyl-CoA hydratase
C2D60_RS13915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D60_RS13920	COG2151	metal-sulfur cluster biosynthetic enzyme
C2D60_RS13925	COG3396	Phenylacetate-CoA oxygenase
C2D60_RS13930	COG3460	Phenylacetate-CoA oxygenase
C2D60_RS13935	COG3396	Phenylacetate-CoA oxygenase
C2D60_RS13940	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS13940	COG2030	dehydratase
C2D60_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS13975	COG2207	Transcriptional regulator
C2D60_RS13980	COG3784	Protein of unknown function (DUF1318)
C2D60_RS13990	COG2911	Protein conserved in bacteria
C2D60_RS13995	COG0586	Pfam SNARE associated Golgi protein
C2D60_RS14000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2D60_RS14005	COG3187	Heat shock protein
C2D60_RS14010	COG3042	response to heat
C2D60_RS14020	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2D60_RS14020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D60_RS14020	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2D60_RS14020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2D60_RS14025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D60_RS14035	COG0589	response to stress
C2D60_RS14045	COG0513	Belongs to the DEAD box helicase family
C2D60_RS14060	COG1349	DNA-binding transcription factor activity
C2D60_RS14065	COG0673	inositol 2-dehydrogenase activity
C2D60_RS14080	COG1113	amino acid transport
C2D60_RS14085	COG1522	sequence-specific DNA binding
C2D60_RS14100	COG2011	ABC-type metal ion transport system permease component
C2D60_RS14115	COG0436	Aminotransferase
C2D60_RS14120	COG0604	alcohol dehydrogenase
C2D60_RS14145	COG0583	DNA-binding transcription factor activity
C2D60_RS14165	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS14170	COG1309	transcriptional regulator
C2D60_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS14245	COG1388	LysM domain
C2D60_RS14245	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2D60_RS14270	COG2885	chlorophyll binding
C2D60_RS14295	COG0693	protein deglycase activity
C2D60_RS14300	COG1078	dGTPase activity
C2D60_RS14305	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS14310	COG0583	DNA-binding transcription factor activity
C2D60_RS14370	COG0784	Response regulator, receiver
C2D60_RS14370	COG2205	protein histidine kinase activity
C2D60_RS14370	COG5002	protein histidine kinase activity
C2D60_RS14375	COG3250	beta-galactosidase activity
C2D60_RS14380	COG0656	L-ascorbic acid biosynthetic process
C2D60_RS14455	COG4166	transmembrane transport
C2D60_RS14460	COG2866	Carboxypeptidase
C2D60_RS14465	COG4948	Mandelate Racemase Muconate Lactonizing
C2D60_RS14470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2D60_RS14475	COG3180	Ammonia monooxygenase
C2D60_RS14485	COG1486	melibiose metabolic process
C2D60_RS14490	COG0583	DNA-binding transcription factor activity
C2D60_RS14500	COG3106	COG3106 Predicted ATPase
C2D60_RS14510	COG1983	PspC domain protein
C2D60_RS14520	COG1842	Phage shock protein A
C2D60_RS14525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D60_RS14550	COG0702	epimerase
C2D60_RS14565	COG4171	peptide transport system, permease
C2D60_RS14580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2D60_RS14590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2D60_RS14595	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D60_RS14595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D60_RS14610	COG1349	DNA-binding transcription factor activity
C2D60_RS14620	COG0023	Translation Initiation Factor
C2D60_RS14630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2D60_RS14635	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2D60_RS14640	COG0671	phosphoesterase, PA-phosphatase related
C2D60_RS14650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2D60_RS14695	COG0616	signal peptide processing
C2D60_RS14705	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS14710	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C2D60_RS14720	COG0583	DNA-binding transcription factor activity
C2D60_RS14730	COG0009	L-threonylcarbamoyladenylate synthase
C2D60_RS14740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2D60_RS14745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2D60_RS14745	COG0512	Glutamine amidotransferase of anthranilate synthase
C2D60_RS14750	COG0134	indole-3-glycerol-phosphate synthase activity
C2D60_RS14750	COG0135	phosphoribosylanthranilate isomerase activity
C2D60_RS14805	COG4774	siderophore transport
C2D60_RS14815	COG3047	cAMP biosynthetic process
C2D60_RS14820	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2D60_RS14850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D60_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS14860	COG1988	membrane-bound metal-dependent
C2D60_RS14865	COG1823	symporter activity
C2D60_RS14875	COG0753	catalase activity
C2D60_RS14885	COG1486	melibiose metabolic process
C2D60_RS14890	COG2169	Transcriptional regulator
C2D60_RS14890	COG1917	Cupin 2, conserved barrel domain protein
C2D60_RS14895	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D60_RS14900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS14905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS14910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D60_RS14920	COG0322	excinuclease ABC activity
C2D60_RS14925	COG3678	ATP-independent chaperone mediated protein folding
C2D60_RS14935	COG3724	N-succinylarginine dihydrolase activity
C2D60_RS14945	COG3138	arginine N-succinyltransferase
C2D60_RS14955	COG0708	Exodeoxyribonuclease III
C2D60_RS14960	COG0398	Pfam SNARE associated Golgi protein
C2D60_RS14965	COG0398	Pfam SNARE associated Golgi protein
C2D60_RS14970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D60_RS14975	COG4134	Bacterial extracellular solute-binding protein
C2D60_RS14980	COG4135	transport system, permease component
C2D60_RS14985	COG4136	ATPase activity
C2D60_RS14990	COG2897	thiosulfate sulfurtransferase activity
C2D60_RS14995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2D60_RS15000	COG0494	nUDIX hydrolase
C2D60_RS15005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2D60_RS15010	COG0604	alcohol dehydrogenase
C2D60_RS15010	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS15010	COG3321	synthase
C2D60_RS15015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2D60_RS15020	COG0709	Synthesizes selenophosphate from selenide and ATP
C2D60_RS15035	COG0778	Nitroreductase
C2D60_RS15040	COG0616	signal peptide processing
C2D60_RS15045	COG0252	asparaginase activity
C2D60_RS15050	COG1335	isochorismatase
C2D60_RS15065	COG3139	Protein of unknown function (DUF1315)
C2D60_RS15085	COG0656	L-ascorbic acid biosynthetic process
C2D60_RS15090	COG3713	MltA-interacting MipA family protein
C2D60_RS15095	COG2766	serine protein kinase
C2D60_RS15110	COG0386	Belongs to the glutathione peroxidase family
C2D60_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS15135	COG0583	DNA-binding transcription factor activity
C2D60_RS15140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2D60_RS15145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2D60_RS15155	COG0859	PFAM glycosyl transferase family 9
C2D60_RS15160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D60_RS15170	COG2207	Transcriptional regulator
C2D60_RS15175	COG2807	transmembrane transport
C2D60_RS15180	COG0504	CTP synthase activity
C2D60_RS15185	COG1683	Conserved Protein
C2D60_RS15190	COG3189	MarR family transcriptional regulator
C2D60_RS15195	COG3042	response to heat
C2D60_RS15200	COG2203	Gaf domain
C2D60_RS15200	COG2199	diguanylate cyclase activity
C2D60_RS15220	COG3182	Iron-regulated membrane protein
C2D60_RS15230	COG1560	Kdo2-lipid A biosynthetic process
C2D60_RS15245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2D60_RS15250	COG3706	GGDEF domain
C2D60_RS15255	COG0583	DNA-binding transcription factor activity
C2D60_RS15260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2D60_RS15365	COG0616	signal peptide processing
C2D60_RS15380	COG4626	Terminase
C2D60_RS15380	COG1802	Transcriptional regulator
C2D60_RS15420	COG3772	lysozyme
C2D60_RS15445	COG1403	HNH endonuclease
C2D60_RS15530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D60_RS15540	COG0582	viral genome integration into host DNA
C2D60_RS15545	COG0538	isocitrate dehydrogenase activity
C2D60_RS15550	COG1187	pseudouridine synthase activity
C2D60_RS15570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2D60_RS15590	COG2205	protein histidine kinase activity
C2D60_RS15595	COG2850	peptidyl-arginine hydroxylation
C2D60_RS15600	COG1943	Transposase
C2D60_RS15625	COG1177	transmembrane transport
C2D60_RS15640	COG0318	PFAM AMP-dependent synthetase and ligase
C2D60_RS15645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D60_RS15650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D60_RS15655	COG0698	ribose 5-phosphate isomerase
C2D60_RS15670	COG3395	kinase activity
C2D60_RS15685	COG2390	Transcriptional regulator
C2D60_RS15695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2D60_RS15705	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2D60_RS15715	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2D60_RS15720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2D60_RS15725	COG1388	LysM domain
C2D60_RS15725	COG1376	ErfK ybiS ycfS ynhG family protein
C2D60_RS15735	COG1309	transcriptional regulator
C2D60_RS15745	COG3134	Outer membrane lipoprotein
C2D60_RS15750	COG1252	NADH dehydrogenase
C2D60_RS15775	COG5633	Lipoprotein
C2D60_RS15780	COG0537	adenosine 5'-monophosphoramidase activity
C2D60_RS15790	COG0084	hydrolase, TatD family'
C2D60_RS15795	COG0470	DNA polymerase III
C2D60_RS15805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2D60_RS15810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2D60_RS15815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D60_RS15830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2D60_RS15850	COG1399	metal-binding, possibly nucleic acid-binding protein
C2D60_RS15870	COG1530	ribonuclease E activity
C2D60_RS15875	COG0583	DNA-binding transcription factor activity
C2D60_RS15880	COG2814	Major facilitator Superfamily
C2D60_RS15900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D60_RS15950	COG1560	Kdo2-lipid A biosynthetic process
C2D60_RS15970	COG5645	(Lipo)protein
C2D60_RS16010	COG3381	protein complex oligomerization
C2D60_RS16035	COG0583	DNA-binding transcription factor activity
C2D60_RS16045	COG1335	isochorismatase
C2D60_RS16060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2D60_RS16065	COG1702	phosphate starvation-inducible protein PhoH
C2D60_RS16085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D60_RS16095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2D60_RS16110	COG1309	transcriptional regulator
C2D60_RS16145	COG2233	PERMEase
C2D60_RS16155	COG3729	General stress protein
C2D60_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS16195	COG0531	amino acid
C2D60_RS16205	COG0174	glutamine synthetase
C2D60_RS16210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2D60_RS16215	COG1917	Cupin 2, conserved barrel domain protein
C2D60_RS16215	COG1396	sequence-specific DNA binding
C2D60_RS16220	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS16225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2D60_RS16230	COG0583	DNA-binding transcription factor activity
C2D60_RS16235	COG0473	3-isopropylmalate dehydrogenase activity
C2D60_RS16245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2D60_RS16250	COG4638	Rieske (2fe-2S)
C2D60_RS16255	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS16260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D60_RS16265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2D60_RS16265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS16265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS16270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS16275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS16280	COG1882	Formate acetyltransferase
C2D60_RS16285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D60_RS16290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D60_RS16300	COG2207	Transcriptional regulator
C2D60_RS16305	COG3706	GGDEF domain
C2D60_RS16325	COG2200	EAL domain
C2D60_RS16335	COG0058	SHG alpha-glucan phosphorylase activity
C2D60_RS16350	COG0670	Belongs to the BI1 family
C2D60_RS16365	COG2207	Transcriptional regulator
C2D60_RS16370	COG1881	PFAM PEBP family protein
C2D60_RS16385	COG1832	CoA-binding protein
C2D60_RS16395	COG0210	DNA helicase
C2D60_RS16400	COG3304	Inner membrane component domain
C2D60_RS16405	COG1289	transmembrane transporter activity
C2D60_RS16410	COG3070	regulator of competence-specific genes
C2D60_RS16435	COG1067	ATP-dependent peptidase activity
C2D60_RS16445	COG3130	regulation of translation
C2D60_RS16450	COG3009	Protein conserved in bacteria
C2D60_RS16455	COG3008	intermembrane lipid transfer
C2D60_RS16455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2D60_RS16460	COG2995	paraquat-inducible protein a
C2D60_RS16465	COG0488	(ABC) transporter
C2D60_RS16475	COG3217	Mosc domain protein beta barrel domain protein
C2D60_RS16475	COG0633	Ferredoxin
C2D60_RS16490	COG0431	NADPH-dependent FMN reductase
C2D60_RS16495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D60_RS16500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D60_RS16505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D60_RS16515	COG0308	aminopeptidase N
C2D60_RS16525	COG1473	amidohydrolase
C2D60_RS16535	COG0814	amino acid
C2D60_RS16545	COG1522	sequence-specific DNA binding
C2D60_RS16555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D60_RS16560	COG1448	Aminotransferase
C2D60_RS16565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2D60_RS16570	COG3108	Peptidase M15
C2D60_RS16575	COG2989	Protein conserved in bacteria
C2D60_RS16585	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2D60_RS16595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2D60_RS16600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2D60_RS16605	COG3173	Aminoglycoside phosphotransferase
C2D60_RS16620	COG3214	Protein conserved in bacteria
C2D60_RS16635	COG0658	competence protein
C2D60_RS16635	COG2333	competence protein COMEC
C2D60_RS16645	COG0539	negative regulation of cytoplasmic translation
C2D60_RS16665	COG2323	membrane
C2D60_RS16670	COG1944	ATP diphosphatase activity
C2D60_RS16675	COG2116	formate transmembrane transporter activity
C2D60_RS16680	COG1882	Formate acetyltransferase
C2D60_RS16685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D60_RS16690	COG0477	Major facilitator Superfamily
C2D60_RS16700	COG3302	dmso reductase anchor subunit
C2D60_RS16705	COG0437	4 iron, 4 sulfur cluster binding
C2D60_RS16710	COG0243	molybdopterin cofactor binding
C2D60_RS16720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2D60_RS16730	COG1178	ABC-type Fe3 transport system permease component
C2D60_RS16730	COG1674	ftsk spoiiie
C2D60_RS16740	COG0492	ferredoxin-NADP+ reductase activity
C2D60_RS16745	COG4988	ABC transporter
C2D60_RS16750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2D60_RS16765	COG0542	response to heat
C2D60_RS16775	COG1278	Cold shock
C2D60_RS16785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS16790	COG3593	DNA synthesis involved in DNA repair
C2D60_RS16800	COG2431	L-lysine efflux transmembrane transporter activity
C2D60_RS16810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D60_RS16820	COG0028	Belongs to the TPP enzyme family
C2D60_RS16825	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2D60_RS16830	COG0702	epimerase
C2D60_RS16835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D60_RS16840	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2D60_RS16845	COG5001	Diguanylate cyclase
C2D60_RS16845	COG2203	Gaf domain
C2D60_RS16845	COG3706	GGDEF domain
C2D60_RS16845	COG4251	negative regulation of phosphorylation
C2D60_RS16860	COG1126	abc transporter atp-binding protein
C2D60_RS16865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS16870	COG4215	(ABC) transporter
C2D60_RS16875	COG4160	amino acid transport
C2D60_RS16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS16885	COG5002	protein histidine kinase activity
C2D60_RS16890	COG0745	RESPONSE REGULATOR receiver
C2D60_RS16905	COG1177	transmembrane transport
C2D60_RS16910	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2D60_RS16915	COG3842	ATPase activity
C2D60_RS16920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2D60_RS16935	COG0778	Nitroreductase
C2D60_RS16960	COG3226	Transcriptional regulator
C2D60_RS16965	COG0738	Major facilitator superfamily
C2D60_RS16970	COG0561	phosphatase activity
C2D60_RS16975	COG2814	Major facilitator Superfamily
C2D60_RS16985	COG0671	phosphoesterase, PA-phosphatase related
C2D60_RS16990	COG1349	DNA-binding transcription factor activity
C2D60_RS16995	COG1686	Belongs to the peptidase S11 family
C2D60_RS17000	COG0625	glutathione transferase activity
C2D60_RS17005	COG2133	pyrroloquinoline quinone binding
C2D60_RS17015	COG2223	nitrite transmembrane transporter activity
C2D60_RS17035	COG0747	negative chemotaxis
C2D60_RS17050	COG0303	'Molybdopterin
C2D60_RS17055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2D60_RS17060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D60_RS17065	COG1882	Formate acetyltransferase
C2D60_RS17070	COG0561	phosphatase activity
C2D60_RS17080	COG1609	Transcriptional regulator
C2D60_RS17085	COG2271	Major facilitator Superfamily
C2D60_RS17095	COG0488	(ABC) transporter
C2D60_RS17100	COG2365	Tyrosine phosphatase family
C2D60_RS17105	COG1376	ErfK ybiS ycfS ynhG family protein
C2D60_RS17110	COG2188	Transcriptional regulator
C2D60_RS17115	COG2723	6-phospho-beta-galactosidase activity
C2D60_RS17120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2D60_RS17135	COG2194	sulfuric ester hydrolase activity
C2D60_RS17140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2D60_RS17155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS17160	COG0765	amino acid transport
C2D60_RS17165	COG1126	abc transporter atp-binding protein
C2D60_RS17170	COG0668	transmembrane transport
C2D60_RS17180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D60_RS17190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2D60_RS17200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2D60_RS17205	COG1199	ATP-dependent helicase activity
C2D60_RS17210	COG0513	Belongs to the DEAD box helicase family
C2D60_RS17215	COG3958	Transketolase
C2D60_RS17220	COG3959	Transketolase, thiamine diphosphate binding domain
C2D60_RS17225	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS17230	COG2271	Major facilitator Superfamily
C2D60_RS17235	COG0583	DNA-binding transcription factor activity
C2D60_RS17240	COG1309	transcriptional regulator
C2D60_RS17245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS17250	COG1131	(ABC) transporter
C2D60_RS17255	COG0842	Transport permease protein
C2D60_RS17260	COG0842	Transport permease protein
C2D60_RS17270	COG3568	Endonuclease Exonuclease Phosphatase
C2D60_RS17275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2D60_RS17280	COG0392	lysyltransferase activity
C2D60_RS17285	COG0670	Belongs to the BI1 family
C2D60_RS17290	COG0314	molybdopterin synthase activity
C2D60_RS17295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2D60_RS17305	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2D60_RS17330	COG0745	RESPONSE REGULATOR receiver
C2D60_RS17335	COG0642	Histidine kinase
C2D60_RS17375	COG2226	methyltransferase
C2D60_RS17390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2D60_RS17395	COG1881	PFAM PEBP family protein
C2D60_RS17435	COG4677	pectinesterase activity
C2D60_RS17445	COG0589	response to stress
C2D60_RS17450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS17480	COG0789	Transcriptional regulator
C2D60_RS17485	COG2200	EAL domain
C2D60_RS17510	COG0561	phosphatase activity
C2D60_RS17515	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2D60_RS17520	COG4149	molybdate abc transporter
C2D60_RS17525	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2D60_RS17535	COG2005	Transcriptional regulator
C2D60_RS17535	COG3585	molybdate ion transport
C2D60_RS17540	COG1119	ATPase activity
C2D60_RS17550	COG1085	galactose-1-phosphate uridylyltransferase
C2D60_RS17560	COG2017	converts alpha-aldose to the beta-anomer
C2D60_RS17570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D60_RS17585	COG3201	nicotinamide mononucleotide transporter
C2D60_RS17590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2D60_RS17640	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2D60_RS17645	COG2885	chlorophyll binding
C2D60_RS17655	COG3064	Membrane
C2D60_RS17660	COG0848	biopolymer transport protein
C2D60_RS17665	COG0811	peptide transport
C2D60_RS17670	COG0824	Thioesterase
C2D60_RS17675	COG3790	cyd operon protein YbgE
C2D60_RS17680	COG4890	Cyd operon protein YbgT
C2D60_RS17685	COG1294	oxidase, subunit
C2D60_RS17690	COG1271	oxidase subunit
C2D60_RS17700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2D60_RS17715	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D60_RS17720	COG0567	Dehydrogenase, E1 component
C2D60_RS17725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2D60_RS17730	COG1053	succinate dehydrogenase
C2D60_RS17735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2D60_RS17740	COG2009	succinate dehydrogenase
C2D60_RS17775	COG1984	allophanate hydrolase subunit 2
C2D60_RS17780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2D60_RS17795	COG0415	Belongs to the DNA photolyase family
C2D60_RS17825	COG2205	protein histidine kinase activity
C2D60_RS17830	COG0745	RESPONSE REGULATOR receiver
C2D60_RS17840	COG0033	Phosphoglucomutase
C2D60_RS17850	COG0596	Alpha beta hydrolase
C2D60_RS17865	COG0735	belongs to the Fur family
C2D60_RS17905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2D60_RS17910	COG1846	Transcriptional regulator
C2D60_RS17910	COG1940	carbohydrate kinase activity
C2D60_RS17915	COG0647	UMP catabolic process
C2D60_RS17920	COG0367	asparagine synthase
C2D60_RS17965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D60_RS17975	COG1702	phosphate starvation-inducible protein PhoH
C2D60_RS18000	COG0765	amino acid transport
C2D60_RS18005	COG0765	amino acid transport
C2D60_RS18010	COG1126	abc transporter atp-binding protein
C2D60_RS18025	COG2888	peptidyl-tyrosine sulfation
C2D60_RS18040	COG1466	dna polymerase III delta subunit
C2D60_RS18055	COG0799	negative regulation of ribosome biogenesis
C2D60_RS18065	COG0768	penicillin binding
C2D60_RS18070	COG0772	Belongs to the SEDS family
C2D60_RS18075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2D60_RS18080	COG1686	Belongs to the peptidase S11 family
C2D60_RS18095	COG0583	DNA-binding transcription factor activity
C2D60_RS18105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2D60_RS18110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2D60_RS18135	COG3069	C4-dicarboxylate transmembrane transporter activity
C2D60_RS18140	COG3719	Belongs to the RNase T2 family
C2D60_RS18145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2D60_RS18165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2D60_RS18170	COG0583	DNA-binding transcription factor activity
C2D60_RS18175	COG3969	phosphoadenosine phosphosulfate
C2D60_RS18180	COG1475	DNA binding
C2D60_RS18185	COG0436	Aminotransferase
C2D60_RS18210	COG1129	ABC transporter
C2D60_RS18215	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS18220	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS18230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D60_RS18245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2D60_RS18255	COG0402	S-adenosylhomocysteine deaminase activity
C2D60_RS18265	COG0483	inositol monophosphate 1-phosphatase activity
C2D60_RS18270	COG2271	Major facilitator Superfamily
C2D60_RS18300	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS18305	COG1129	ABC transporter
C2D60_RS18310	COG0371	Dehydrogenase
C2D60_RS18315	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS18330	COG2879	small protein
C2D60_RS18335	COG1966	Carbon starvation protein
C2D60_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS18350	COG3433	isochorismatase activity
C2D60_RS18350	COG1535	isochorismatase
C2D60_RS18355	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2D60_RS18360	COG1169	isochorismate synthase
C2D60_RS18365	COG4592	Periplasmic binding protein
C2D60_RS18375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS18380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS18385	COG1120	ATPase activity
C2D60_RS18390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2D60_RS18390	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2D60_RS18395	COG3251	PFAM MbtH domain protein
C2D60_RS18400	COG2382	esterase
C2D60_RS18410	COG4771	TonB-dependent receptor
C2D60_RS18415	COG2977	Belongs to the P-Pant transferase superfamily
C2D60_RS18420	COG3958	Transketolase
C2D60_RS18425	COG3959	Transketolase, thiamine diphosphate binding domain
C2D60_RS18435	COG2390	Transcriptional regulator
C2D60_RS18440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2D60_RS18445	COG1879	ABC-type sugar transport system periplasmic component
C2D60_RS18455	COG1129	ABC transporter
C2D60_RS18460	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS18470	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS18480	COG0583	DNA-binding transcription factor activity
C2D60_RS18485	COG0668	transmembrane transport
C2D60_RS18495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2D60_RS18520	COG0747	negative chemotaxis
C2D60_RS18525	COG0601	transmembrane transport
C2D60_RS18530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D60_RS18535	COG0444	Belongs to the ABC transporter superfamily
C2D60_RS18540	COG4608	Belongs to the ABC transporter superfamily
C2D60_RS18555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2D60_RS18560	COG4221	oxidoreductase activity
C2D60_RS18570	COG4215	(ABC) transporter
C2D60_RS18575	COG0765	amino acid transport
C2D60_RS18580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2D60_RS18595	COG0697	spore germination
C2D60_RS18610	COG4608	Belongs to the ABC transporter superfamily
C2D60_RS18615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D60_RS18635	COG3698	Phosphodiester glycosidase
C2D60_RS18680	COG2315	Protein conserved in bacteria
C2D60_RS18685	COG0778	Nitroreductase
C2D60_RS18695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS18705	COG3716	PTS system mannose fructose sorbose family IID component
C2D60_RS18710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2D60_RS18715	COG2222	sugar isomerase
C2D60_RS18720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D60_RS18720	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2D60_RS18740	COG0477	Major facilitator Superfamily
C2D60_RS18745	COG0668	transmembrane transport
C2D60_RS18750	COG1609	Transcriptional regulator
C2D60_RS18760	COG0673	inositol 2-dehydrogenase activity
C2D60_RS18770	COG2211	Major facilitator Superfamily
C2D60_RS18775	COG1113	amino acid transport
C2D60_RS18790	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS18795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2D60_RS18805	COG0531	amino acid
C2D60_RS18870	COG0667	Aldo Keto reductase
C2D60_RS18875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS18880	COG1473	amidohydrolase
C2D60_RS18900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS18905	COG1120	ATPase activity
C2D60_RS18910	COG1566	PFAM secretion protein HlyD family protein
C2D60_RS18955	COG4211	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS18960	COG1129	ABC transporter
C2D60_RS18975	COG0673	inositol 2-dehydrogenase activity
C2D60_RS19005	COG3104	oligopeptide transport
C2D60_RS19010	COG1982	Orn Lys Arg decarboxylase major
C2D60_RS19015	COG0531	amino acid
C2D60_RS19025	COG3710	Transcriptional regulator
C2D60_RS19035	COG1560	Kdo2-lipid A biosynthetic process
C2D60_RS19050	COG3188	usher protein
C2D60_RS19055	COG3121	Chaperone
C2D60_RS19060	COG3539	Fimbrial protein
C2D60_RS19115	COG2501	S4 domain
C2D60_RS19120	COG1988	membrane-bound metal-dependent
C2D60_RS19140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2D60_RS19155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2D60_RS19160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2D60_RS19165	COG0549	Belongs to the carbamate kinase family
C2D60_RS19175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2D60_RS19180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2D60_RS19185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2D60_RS19190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2D60_RS19195	COG3257	ureidoglycine aminohydrolase activity
C2D60_RS19200	COG1929	Belongs to the glycerate kinase type-1 family
C2D60_RS19205	COG2233	PERMEase
C2D60_RS19215	COG1953	Uracil, thiamine, allantoin
C2D60_RS19225	COG2084	Dehydrogenase
C2D60_RS19230	COG3622	Belongs to the hyi family
C2D60_RS19235	COG3960	tartronate-semialdehyde synthase activity
C2D60_RS19270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2D60_RS19275	COG4181	ATPase activity
C2D60_RS19280	COG2755	lipolytic protein G-D-S-L family
C2D60_RS19285	COG0300	oxidoreductase activity
C2D60_RS19290	COG3118	belongs to the thioredoxin family
C2D60_RS19300	COG0390	transport system, permease component
C2D60_RS19305	COG4619	ABC transporter
C2D60_RS19310	COG0330	HflC and HflK could
C2D60_RS19315	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2D60_RS19330	COG3735	TraB family
C2D60_RS19335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D60_RS19345	COG2223	nitrite transmembrane transporter activity
C2D60_RS19350	COG4651	solute:proton antiporter activity
C2D60_RS19350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2D60_RS19355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D60_RS19395	COG2832	Protein of unknown function (DUF454)
C2D60_RS19400	COG3923	Primosomal replication protein n
C2D60_RS19415	COG3264	Mechanosensitive ion channel
C2D60_RS19415	COG1196	nuclear chromosome segregation
C2D60_RS19425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS19430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D60_RS19445	COG0110	maltose O-acetyltransferase activity
C2D60_RS19490	COG1874	Beta-galactosidase
C2D60_RS19495	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2D60_RS19500	COG3833	ABC-type maltose transport systems, permease component
C2D60_RS19505	COG1175	transmembrane transport
C2D60_RS19510	COG2182	Extracellular solute-binding protein
C2D60_RS19520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2D60_RS19535	COG2364	Membrane
C2D60_RS19565	COG3695	enzyme binding
C2D60_RS19570	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2D60_RS19575	COG1946	Acyl-CoA thioesterase
C2D60_RS19580	COG0004	ammonium transporteR
C2D60_RS19585	COG0347	Belongs to the P(II) protein family
C2D60_RS19590	COG1132	(ABC) transporter
C2D60_RS19595	COG1132	(ABC) transporter
C2D60_RS19600	COG1522	sequence-specific DNA binding
C2D60_RS19615	COG4533	DNA binding
C2D60_RS19625	COG0824	Thioesterase
C2D60_RS19630	COG1555	photosystem II stabilization
C2D60_RS19635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D60_RS19640	COG0776	regulation of translation
C2D60_RS19645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2D60_RS19675	COG0271	Belongs to the BolA IbaG family
C2D60_RS19680	COG3056	Lipoprotein
C2D60_RS19685	COG2223	nitrite transmembrane transporter activity
C2D60_RS19690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2D60_RS19695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2D60_RS19700	COG1845	cytochrome c oxidase, subunit III
C2D60_RS19705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2D60_RS19720	COG1414	Transcriptional regulator
C2D60_RS19725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2D60_RS19730	COG1053	succinate dehydrogenase
C2D60_RS19740	COG1053	succinate dehydrogenase
C2D60_RS19755	COG0673	inositol 2-dehydrogenase activity
C2D60_RS19760	COG2814	Major facilitator Superfamily
C2D60_RS19770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2D60_RS19775	COG0693	protein deglycase activity
C2D60_RS19795	COG0142	geranyltranstransferase activity
C2D60_RS19805	COG0667	Aldo Keto reductase
C2D60_RS19810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2D60_RS19830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2D60_RS19830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2D60_RS19840	COG4238	major outer membrane lipoprotein
C2D60_RS19860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2D60_RS19865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2D60_RS19870	COG1862	Preprotein translocase
C2D60_RS19890	COG0450	alkyl hydroperoxide reductase
C2D60_RS19895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS19910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D60_RS19920	COG1228	amidohydrolase
C2D60_RS19930	COG1335	isochorismatase
C2D60_RS19935	COG0583	DNA-binding transcription factor activity
C2D60_RS19940	COG0366	Alpha amylase catalytic
C2D60_RS19965	COG0420	3'-5' exonuclease activity
C2D60_RS19970	COG0419	ATPase involved in DNA repair
C2D60_RS19975	COG1940	carbohydrate kinase activity
C2D60_RS19990	COG4126	flavin adenine dinucleotide binding
C2D60_RS20000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2D60_RS20005	COG3416	Protein conserved in bacteria
C2D60_RS20015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2D60_RS20025	COG1785	Belongs to the alkaline phosphatase family
C2D60_RS20065	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2D60_RS20070	COG1335	isochorismatase
C2D60_RS20075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2D60_RS20080	COG0113	porphobilinogen synthase activity
C2D60_RS20090	COG2175	clavaminate synthase activity
C2D60_RS20095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D60_RS20100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2D60_RS20105	COG4521	taurine ABC transporter
C2D60_RS20110	COG2040	homocysteine
C2D60_RS20115	COG0833	amino acid
C2D60_RS20135	COG4303	Ethanolamine ammonia lyase large subunit
C2D60_RS20140	COG4302	ethanolamine ammonia-lyase activity
C2D60_RS20180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS20185	COG1126	abc transporter atp-binding protein
C2D60_RS20190	COG4597	amino acid ABC transporter
C2D60_RS20195	COG0765	amino acid transport
C2D60_RS20210	COG3188	usher protein
C2D60_RS20245	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2D60_RS20255	COG3639	organic phosphonate transmembrane transporter activity
C2D60_RS20285	COG0791	NLP P60 protein
C2D60_RS20340	COG2909	trisaccharide binding
C2D60_RS20345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2D60_RS20350	COG0022	dehydrogenase e1 component
C2D60_RS20355	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D60_RS20360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D60_RS20385	COG1070	Carbohydrate kinase
C2D60_RS20390	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS20395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D60_RS20400	COG3775	system Galactitol-specific IIC component
C2D60_RS20405	COG0625	glutathione transferase activity
C2D60_RS20410	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2D60_RS20430	COG0579	oxidoreductase
C2D60_RS20435	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS20440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D60_RS20445	COG1113	amino acid transport
C2D60_RS20450	COG1802	Transcriptional regulator
C2D60_RS20470	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2D60_RS20475	COG0454	-acetyltransferase
C2D60_RS20490	COG2991	Protein conserved in bacteria
C2D60_RS20505	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2D60_RS20510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2D60_RS20530	COG3034	peptidoglycan biosynthetic process
C2D60_RS20535	COG0121	glutamine amidotransferase
C2D60_RS20545	COG1960	acyl-CoA dehydrogenase activity
C2D60_RS20550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2D60_RS20560	COG0583	DNA-binding transcription factor activity
C2D60_RS20570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D60_RS20580	COG2226	methyltransferase
C2D60_RS20590	COG1388	LysM domain
C2D60_RS20590	COG0741	lytic transglycosylase activity
C2D60_RS20595	COG2226	methyltransferase
C2D60_RS20605	COG2814	Major facilitator Superfamily
C2D60_RS20610	COG0583	DNA-binding transcription factor activity
C2D60_RS20615	COG0656	L-ascorbic acid biosynthetic process
C2D60_RS20650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2D60_RS20660	COG2011	ABC-type metal ion transport system permease component
C2D60_RS20665	COG1464	Belongs to the NlpA lipoprotein family
C2D60_RS20675	COG1720	tRNA m6t6A37 methyltransferase activity
C2D60_RS20685	COG0791	NLP P60 protein
C2D60_RS20690	COG3015	lipoprotein NlpE involved in copper resistance
C2D60_RS20695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2D60_RS20710	COG4568	rho-dependent transcription termination
C2D60_RS20720	COG0346	lactoylglutathione lyase activity
C2D60_RS20725	COG1982	Orn Lys Arg decarboxylase major
C2D60_RS20735	COG0587	DNA-directed DNA polymerase activity
C2D60_RS20765	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2D60_RS20775	COG0750	zinc metalloprotease
C2D60_RS20780	COG0575	Belongs to the CDS family
C2D60_RS20795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2D60_RS20820	COG0024	Methionine aminopeptidase
C2D60_RS20825	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2D60_RS20840	COG3835	regulator
C2D60_RS20845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D60_RS20865	COG2860	membrane
C2D60_RS20885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS20890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2D60_RS20895	COG1120	ATPase activity
C2D60_RS20900	COG4774	siderophore transport
C2D60_RS20905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2D60_RS20995	COG1643	Atp-dependent helicase
C2D60_RS21000	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2D60_RS21020	COG0617	tRNA 3'-terminal CCA addition
C2D60_RS21025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2D60_RS21045	COG0726	polysaccharide deacetylase
C2D60_RS21050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS21055	COG0842	Transport permease protein
C2D60_RS21060	COG1131	(ABC) transporter
C2D60_RS21065	COG0288	reversible hydration of carbon dioxide
C2D60_RS21075	COG4993	Dehydrogenase
C2D60_RS21080	COG2132	Multicopper oxidase
C2D60_RS21125	COG3064	Membrane
C2D60_RS21140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D60_RS21145	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D60_RS21150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2D60_RS21155	COG2186	Transcriptional regulator
C2D60_RS21160	COG1113	amino acid transport
C2D60_RS21165	COG2211	Major facilitator Superfamily
C2D60_RS21170	COG3940	Belongs to the glycosyl hydrolase 43 family
C2D60_RS21175	COG3725	Membrane protein required for beta-lactamase induction
C2D60_RS21180	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2D60_RS21190	COG4969	Belongs to the N-Me-Phe pilin family
C2D60_RS21195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2D60_RS21200	COG1459	type II secretion system
C2D60_RS21225	COG0494	nUDIX hydrolase
C2D60_RS21245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2D60_RS21250	COG0849	cell division
C2D60_RS21275	COG0772	Belongs to the SEDS family
C2D60_RS21290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2D60_RS21295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2D60_RS21300	COG0768	penicillin binding
C2D60_RS21320	COG1609	Transcriptional regulator
C2D60_RS21330	COG0028	Belongs to the TPP enzyme family
C2D60_RS21380	COG0738	Major facilitator superfamily
C2D60_RS21390	COG0583	DNA-binding transcription factor activity
C2D60_RS21395	COG2271	Major facilitator Superfamily
C2D60_RS21400	COG2814	Major facilitator Superfamily
C2D60_RS21420	COG1178	ABC-type Fe3 transport system permease component
C2D60_RS21430	COG0586	Pfam SNARE associated Golgi protein
C2D60_RS21450	COG0235	Class ii aldolase
C2D60_RS21455	COG0417	DNA replication proofreading
C2D60_RS21465	COG0564	pseudouridine synthase activity
C2D60_RS21480	COG3493	citrate carrier protein
C2D60_RS21495	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2D60_RS21500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2D60_RS21510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2D60_RS21565	COG0505	Belongs to the CarA family
C2D60_RS21575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2D60_RS21600	COG1047	Peptidyl-prolyl cis-trans
C2D60_RS21615	COG0196	riboflavin kinase activity
C2D60_RS21630	COG0583	DNA-binding transcription factor activity
C2D60_RS21655	COG4735	regulation of single-species biofilm formation
C2D60_RS21660	COG1584	GPR1 FUN34 yaaH family protein
C2D60_RS21665	COG0477	Major facilitator Superfamily
C2D60_RS21670	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2D60_RS21675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D60_RS21680	COG1115	amino acid carrier protein
C2D60_RS21695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2D60_RS21705	COG0460	homoserine dehydrogenase
C2D60_RS21705	COG0527	aspartate kinase activity
C2D60_RS21715	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2D60_RS21725	COG0745	RESPONSE REGULATOR receiver
C2D60_RS21730	COG4452	Inner membrane protein CreD
C2D60_RS21735	COG2205	protein histidine kinase activity
C2D60_RS21740	COG0745	RESPONSE REGULATOR receiver
C2D60_RS21745	COG3045	CreA protein
C2D60_RS21750	COG2207	Transcriptional regulator
C2D60_RS21750	COG3708	Transcriptional regulator
C2D60_RS21770	COG0741	lytic transglycosylase activity
C2D60_RS21775	COG0488	(ABC) transporter
C2D60_RS21785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2D60_RS21790	COG0560	Phosphoserine phosphatase
C2D60_RS21800	COG3726	membrane protein affecting hemolysin expression
C2D60_RS21830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D60_RS21835	COG0084	hydrolase, TatD family'
C2D60_RS21840	COG4667	esterase of the alpha-beta hydrolase superfamily
C2D60_RS21850	COG2823	Periplasmic or secreted lipoprotein
C2D60_RS21860	COG1011	Hydrolase
C2D60_RS21865	COG0456	acetyltransferase
C2D60_RS21870	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2D60_RS22025	COG0071	Belongs to the small heat shock protein (HSP20) family
C2D60_RS22140	COG1216	Glycosyl transferase, family 2
C2D60_RS22160	COG3507	Belongs to the glycosyl hydrolase 43 family
C2D60_RS22165	COG2211	Major facilitator Superfamily
C2D60_RS22170	COG2115	Belongs to the xylose isomerase family
C2D60_RS22175	COG4580	involved in the transport of maltose and maltodextrins
C2D60_RS22185	COG3272	Protein of unknown function (DUF1722)
C2D60_RS22205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2D60_RS22220	COG0300	oxidoreductase activity
C2D60_RS22225	COG3631	Ketosteroid isomerase-related protein
C2D60_RS22230	COG0789	Transcriptional regulator
C2D60_RS22235	COG3040	lipid binding
C2D60_RS22245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D60_RS22250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS22255	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS22260	COG1538	Outer membrane efflux protein
C2D60_RS22270	COG0745	RESPONSE REGULATOR receiver
C2D60_RS22275	COG5002	protein histidine kinase activity
C2D60_RS22290	COG2850	peptidyl-arginine hydroxylation
C2D60_RS22325	COG0842	Transport permease protein
C2D60_RS22330	COG1129	ABC transporter
C2D60_RS22330	COG0842	Transport permease protein
C2D60_RS22335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS22345	COG1879	ABC-type sugar transport system periplasmic component
C2D60_RS22350	COG1129	ABC transporter
C2D60_RS22355	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS22365	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2D60_RS22370	COG0583	DNA-binding transcription factor activity
C2D60_RS22380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D60_RS22385	COG5457	Domain of unknown function (DUF1127)
C2D60_RS22395	COG1566	PFAM secretion protein HlyD family protein
C2D60_RS22410	COG1924	4 iron, 4 sulfur cluster binding
C2D60_RS22415	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2D60_RS22430	COG2733	membrane
C2D60_RS22440	COG1917	Cupin 2, conserved barrel domain protein
C2D60_RS22440	COG2207	Transcriptional regulator
C2D60_RS22445	COG5464	transposase or invertase
C2D60_RS22450	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS22460	COG0523	cobalamin synthesis protein
C2D60_RS22465	COG2879	small protein
C2D60_RS22470	COG1966	Carbon starvation protein
C2D60_RS22485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D60_RS22490	COG2368	4-hydroxyphenylacetate
C2D60_RS22510	COG3971	2-oxopent-4-enoate hydratase activity
C2D60_RS22535	COG3384	dioxygenase
C2D60_RS22540	COG1012	belongs to the aldehyde dehydrogenase family
C2D60_RS22550	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2D60_RS22555	COG1846	Transcriptional regulator
C2D60_RS22580	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2D60_RS22595	COG3734	2-keto-3-deoxy-galactonokinase
C2D60_RS22600	COG0800	Aldolase
C2D60_RS22605	COG1737	Transcriptional regulator
C2D60_RS22615	COG1214	PFAM Peptidase M22, glycoprotease
C2D60_RS22615	COG0456	acetyltransferase
C2D60_RS22620	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2D60_RS22620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D60_RS22635	COG3715	PTS system
C2D60_RS22640	COG3716	PTS system mannose fructose sorbose family IID component
C2D60_RS22645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2D60_RS22655	COG5464	transposase or invertase
C2D60_RS22670	COG1484	DNA-dependent DNA replication
C2D60_RS22685	COG2966	Psort location CytoplasmicMembrane, score
C2D60_RS22705	COG2197	response regulator
C2D60_RS22710	COG2197	response regulator
C2D60_RS22715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D60_RS22720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS22720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS22725	COG4114	ferric iron reductase
C2D60_RS22760	COG3423	Transcriptional regulator
C2D60_RS22775	COG3732	PTS system glucitol sorbitol-specific
C2D60_RS22780	COG0673	inositol 2-dehydrogenase activity
C2D60_RS22800	COG3121	Chaperone
C2D60_RS22810	COG0582	viral genome integration into host DNA
C2D60_RS22905	COG0582	viral genome integration into host DNA
C2D60_RS22920	COG0288	reversible hydration of carbon dioxide
C2D60_RS22925	COG0659	secondary active sulfate transmembrane transporter activity
C2D60_RS22930	COG1064	alcohol dehydrogenase
C2D60_RS22935	COG1175	transmembrane transport
C2D60_RS22940	COG0395	ABC-type sugar transport system, permease component
C2D60_RS22945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2D60_RS22950	COG3842	ATPase activity
C2D60_RS22965	COG1082	Xylose isomerase domain protein TIM barrel
C2D60_RS22975	COG3962	Belongs to the TPP enzyme family
C2D60_RS22980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D60_RS22985	COG1737	Transcriptional regulator
C2D60_RS22985	COG0837	glucose binding
C2D60_RS23005	COG3718	enzyme involved in inositol metabolism
C2D60_RS23020	COG0433	COG0433 Predicted ATPase
C2D60_RS23025	COG0795	lipopolysaccharide-transporting ATPase activity
C2D60_RS23030	COG0795	lipopolysaccharide-transporting ATPase activity
C2D60_RS23045	COG2927	DNA polymerase III (CHI subunit)
C2D60_RS23050	COG0525	valine-tRNA ligase activity
C2D60_RS23075	COG2731	YhcH YjgK YiaL family protein
C2D60_RS23115	COG1263	PTS System
C2D60_RS23115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D60_RS23120	COG0366	Alpha amylase catalytic
C2D60_RS23125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D60_RS23130	COG1486	melibiose metabolic process
C2D60_RS23150	COG0602	queuosine metabolic process
C2D60_RS23155	COG2026	Addiction module toxin, RelE StbE family
C2D60_RS23160	COG3077	Addiction module antitoxin, RelB DinJ family
C2D60_RS23165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D60_RS23165	COG3711	transcriptional antiterminator
C2D60_RS23170	COG2706	6-phosphogluconolactonase activity
C2D60_RS23185	COG3964	amidohydrolase
C2D60_RS23220	COG0312	modulator of DNA gyrase
C2D60_RS23240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2D60_RS23250	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS23255	COG1129	ABC transporter
C2D60_RS23260	COG1879	ABC-type sugar transport system periplasmic component
C2D60_RS23275	COG2105	PFAM AIG2 family protein
C2D60_RS23280	COG2911	Protein conserved in bacteria
C2D60_RS23285	COG0729	surface antigen
C2D60_RS23295	COG1253	flavin adenine dinucleotide binding
C2D60_RS23310	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2D60_RS23325	COG1733	regulation of RNA biosynthetic process
C2D60_RS23330	COG0702	epimerase
C2D60_RS23340	COG0697	spore germination
C2D60_RS23350	COG1113	amino acid transport
C2D60_RS23355	COG0545	Peptidyl-prolyl cis-trans isomerase
C2D60_RS23360	COG3061	Opacity-associated protein A
C2D60_RS23370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2D60_RS23375	COG2965	DNA replication, synthesis of RNA primer
C2D60_RS23435	COG1073	alpha beta
C2D60_RS23440	COG3650	response to hydrogen peroxide
C2D60_RS23450	COG1960	acyl-CoA dehydrogenase activity
C2D60_RS23455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D60_RS23460	COG0557	exoribonuclease II activity
C2D60_RS23475	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2D60_RS23485	COG0330	HflC and HflK could
C2D60_RS23490	COG0330	HflC and HflK could
C2D60_RS23495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2D60_RS23515	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D60_RS23520	COG0802	atpase or kinase
C2D60_RS23525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2D60_RS23525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2D60_RS23530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2D60_RS23555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D60_RS23580	COG1511	domain protein
C2D60_RS23580	COG3264	Mechanosensitive ion channel
C2D60_RS23595	COG1053	succinate dehydrogenase
C2D60_RS23600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2D60_RS23620	COG2076	Multidrug Resistance protein
C2D60_RS23625	COG5510	response to toxic substance
C2D60_RS23640	COG1509	lysine 2,3-aminomutase activity
C2D60_RS23705	COG0531	amino acid
C2D60_RS23710	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2D60_RS23720	COG1027	Aspartate ammonia-lyase
C2D60_RS23725	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2D60_RS23740	COG1309	transcriptional regulator
C2D60_RS23770	COG0457	Tetratricopeptide repeat
C2D60_RS23775	COG0726	polysaccharide deacetylase
C2D60_RS23775	COG1649	PFAM Uncharacterised BCR, COG1649
C2D60_RS23780	COG1215	transferase activity, transferring glycosyl groups
C2D60_RS23800	COG0861	Integral membrane protein TerC family
C2D60_RS23830	COG1486	melibiose metabolic process
C2D60_RS23840	COG2169	Transcriptional regulator
C2D60_RS23855	COG2824	Alkylphosphonate utilization operon protein PhnA
C2D60_RS23860	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C2D60_RS23865	COG2188	Transcriptional regulator
C2D60_RS23870	COG3624	Phosphonate C-P lyase system protein PhnG
C2D60_RS23875	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2D60_RS23880	COG3626	phosphonate metabolism
C2D60_RS23885	COG3627	carbon phosphorus lyase activity
C2D60_RS23890	COG4107	phosphonate C-P lyase system protein PhnK
C2D60_RS23895	COG4778	phosphonate C-P lyase system protein PhnL
C2D60_RS23900	COG3454	Phosphonate metabolism
C2D60_RS23910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2D60_RS23920	COG0784	Response regulator, receiver
C2D60_RS23920	COG4191	Histidine kinase
C2D60_RS23925	COG1129	ABC transporter
C2D60_RS23930	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS23955	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2D60_RS23960	COG1301	dicarboxylic acid transport
C2D60_RS23970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2D60_RS23980	COG3162	membrane
C2D60_RS24010	COG3539	Fimbrial protein
C2D60_RS24015	COG1346	cytolysis
C2D60_RS24020	COG1380	Effector of murein hydrolase LrgA
C2D60_RS24025	COG0583	DNA-binding transcription factor activity
C2D60_RS24030	COG0025	NhaP-type Na H and K H
C2D60_RS24035	COG2252	PERMEase
C2D60_RS24040	COG0625	glutathione transferase activity
C2D60_RS24045	COG0789	Transcriptional regulator
C2D60_RS24055	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2D60_RS24090	COG1234	tRNA 3'-trailer cleavage
C2D60_RS24095	COG1609	Transcriptional regulator
C2D60_RS24100	COG0483	inositol monophosphate 1-phosphatase activity
C2D60_RS24115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D60_RS24135	COG4771	TonB-dependent receptor
C2D60_RS24140	COG0741	lytic transglycosylase activity
C2D60_RS24160	COG2315	Protein conserved in bacteria
C2D60_RS24165	COG0432	Pfam Uncharacterised protein family UPF0047
C2D60_RS24180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2D60_RS24185	COG0305	Participates in initiation and elongation during chromosome replication
C2D60_RS24200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2D60_RS24210	COG0735	belongs to the Fur family
C2D60_RS24215	COG3237	CsbD-like
C2D60_RS24220	COG0534	Mate efflux family protein
C2D60_RS24230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2D60_RS24305	COG0251	oxidation-reduction process
C2D60_RS24315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2D60_RS24335	COG0527	aspartate kinase activity
C2D60_RS24385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2D60_RS24395	COG0456	acetyltransferase
C2D60_RS24430	COG0151	Belongs to the GarS family
C2D60_RS24440	COG4191	Histidine kinase
C2D60_RS24445	COG3678	ATP-independent chaperone mediated protein folding
C2D60_RS24480	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2D60_RS24495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2D60_RS24500	COG2104	thiamine diphosphate biosynthetic process
C2D60_RS24515	COG3706	GGDEF domain
C2D60_RS24525	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D60_RS24530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2D60_RS24565	COG0250	Participates in transcription elongation, termination and antitermination
C2D60_RS24645	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2D60_RS24655	COG1739	Uncharacterized protein family UPF0029
C2D60_RS24700	COG0805	protein transport
C2D60_RS24720	COG3165	ubiquinone biosynthetic process from chorismate
C2D60_RS24750	COG0583	DNA-binding transcription factor activity
C2D60_RS24755	COG0697	spore germination
C2D60_RS24760	COG0561	phosphatase activity
C2D60_RS24765	COG2267	carboxylic ester hydrolase activity
C2D60_RS24770	COG1280	lysine exporter protein (LysE YggA)
C2D60_RS24780	COG1280	lysine exporter protein (LysE YggA)
C2D60_RS24810	COG0210	DNA helicase
C2D60_RS24815	COG1011	Hydrolase
C2D60_RS24845	COG3072	Adenylate cyclase
C2D60_RS24860	COG2959	enzyme of heme biosynthesis
C2D60_RS24865	COG3071	HemY protein
C2D60_RS24910	COG2244	polysaccharide biosynthetic process
C2D60_RS24915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2D60_RS24920	COG0456	acetyltransferase
C2D60_RS24925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2D60_RS24930	COG1088	dTDP-glucose 4,6-dehydratase activity
C2D60_RS24935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2D60_RS24940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2D60_RS24950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2D60_RS24955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2D60_RS24965	COG3118	belongs to the thioredoxin family
C2D60_RS24995	COG1811	Na channel or pump
C2D60_RS25005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D60_RS25010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D60_RS25020	COG0583	DNA-binding transcription factor activity
C2D60_RS25025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2D60_RS25040	COG3978	acetolactate synthase activity
C2D60_RS25060	COG3085	chromosome segregation
C2D60_RS25135	COG0583	DNA-binding transcription factor activity
C2D60_RS25160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2D60_RS25175	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2D60_RS25180	COG2207	Transcriptional regulator
C2D60_RS25190	COG0371	Dehydrogenase
C2D60_RS25195	COG0697	spore germination
C2D60_RS25205	COG0583	DNA-binding transcription factor activity
C2D60_RS25215	COG0737	Belongs to the 5'-nucleotidase family
C2D60_RS25225	COG0460	homoserine dehydrogenase
C2D60_RS25225	COG0527	aspartate kinase activity
C2D60_RS25230	COG0626	cystathionine gamma-synthase activity
C2D60_RS25245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2D60_RS25250	COG1609	Transcriptional regulator
C2D60_RS25255	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2D60_RS25270	COG1575	Belongs to the MenA family. Type 1 subfamily
C2D60_RS25290	COG3678	ATP-independent chaperone mediated protein folding
C2D60_RS25295	COG0745	RESPONSE REGULATOR receiver
C2D60_RS25300	COG2205	protein histidine kinase activity
C2D60_RS25305	COG2258	MOSC domain
C2D60_RS25310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2D60_RS25355	COG1129	ABC transporter
C2D60_RS25360	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS25365	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS25370	COG1454	alcohol dehydrogenase
C2D60_RS25380	COG2211	Major facilitator Superfamily
C2D60_RS25440	COG0205	6-phosphofructokinase activity
C2D60_RS25455	COG0243	molybdopterin cofactor binding
C2D60_RS25455	COG3383	formate dehydrogenase (NAD+) activity
C2D60_RS25460	COG3383	formate dehydrogenase (NAD+) activity
C2D60_RS25460	COG0243	molybdopterin cofactor binding
C2D60_RS25465	COG0437	4 iron, 4 sulfur cluster binding
C2D60_RS25470	COG2864	formate dehydrogenase
C2D60_RS25485	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2D60_RS25495	COG0456	acetyltransferase
C2D60_RS25510	COG1011	Hydrolase
C2D60_RS25525	COG3852	Histidine kinase
C2D60_RS25535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2D60_RS25570	COG0204	Acyl-transferase
C2D60_RS25580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2D60_RS25585	COG3084	Protein conserved in bacteria
C2D60_RS25595	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2D60_RS25620	COG2186	Transcriptional regulator
C2D60_RS25625	COG0477	Major facilitator Superfamily
C2D60_RS25630	COG1609	Transcriptional regulator
C2D60_RS25635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D60_RS25645	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D60_RS25650	COG1129	ABC transporter
C2D60_RS25680	COG1522	sequence-specific DNA binding
C2D60_RS25685	COG0716	FMN binding
C2D60_RS25700	COG3312	ion transport
C2D60_RS25760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2D60_RS25765	COG0573	inorganic phosphate transmembrane transporter activity
C2D60_RS25770	COG0581	inorganic phosphate transmembrane transporter activity
C2D60_RS25775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2D60_RS25780	COG0704	Plays a role in the regulation of phosphate uptake
C2D60_RS25795	COG2382	esterase
C2D60_RS25800	COG0363	glucosamine-6-phosphate deaminase activity
C2D60_RS25805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D60_RS25815	COG2252	PERMEase
C2D60_RS25820	COG0431	NADPH-dependent FMN reductase
C2D60_RS25825	COG2091	lysine biosynthetic process via aminoadipic acid
C2D60_RS25855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2D60_RS25870	COG5654	RES domain protein
C2D60_RS25890	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D60_RS25905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2D60_RS25920	COG0789	Transcriptional regulator
C2D60_RS25930	COG2205	protein histidine kinase activity
C2D60_RS25935	COG0745	RESPONSE REGULATOR receiver
C2D60_RS25940	COG1276	copper resistance
C2D60_RS25945	COG2372	response to copper ion
C2D60_RS25950	COG3667	copper resistance
C2D60_RS25955	COG2132	Multicopper oxidase
C2D60_RS25965	COG0739	heme binding
C2D60_RS25995	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D60_RS26185	COG3436	PFAM IS66 Orf2 family protein
C2D60_RS26190	COG4372	Transposase
C2D60_RS26290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D60_RS26315	COG2144	transferase activity, transferring acyl groups
C2D60_RS26355	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
C2D60_RS26375	COG4245	von Willebrand factor, type A
C2D60_RS26380	COG4245	von Willebrand factor, type A
C2D60_RS26390	COG4245	von Willebrand factor, type A
C2D60_RS26410	COG1358	cellular component organization or biogenesis
C2D60_RS26505	COG0604	alcohol dehydrogenase
C2D60_RS26505	COG1028	Short-chain dehydrogenase reductase Sdr
C2D60_RS26505	COG3321	synthase
C2D60_RS26570	COG1522	sequence-specific DNA binding
C2D60_RS26645	COG1956	GAF domain-containing protein
C2D60_RS26650	COG1956	GAF domain-containing protein
C2D60_RS26755	COG0523	cobalamin synthesis protein
C2D60_RS26760	COG0500	methyltransferase
C2D60_RS26775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D60_RS26785	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C2D60_RS26820	COG0500	methyltransferase
C2D60_RS26855	COG2382	esterase
C2D60_RS26875	COG1475	DNA binding
C2D60_RS26905	COG1595	DNA-templated transcription, initiation
C2D60_RS26915	COG4772	TonB-dependent receptor
C2D60_RS26920	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2D60_RS26935	COG5642	Protein of unknown function (DUF2384)