locus-tag	class	description
C2D61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2D61_RS00020	COG0187	DNA topoisomerase II activity
C2D61_RS00025	COG0561	phosphatase activity
C2D61_RS00040	COG2186	Transcriptional regulator
C2D61_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
C2D61_RS00050	COG0800	Aldolase
C2D61_RS00060	COG2271	Major facilitator Superfamily
C2D61_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
C2D61_RS00070	COG5645	(Lipo)protein
C2D61_RS00095	COG2188	Transcriptional regulator
C2D61_RS00110	COG2149	membrane
C2D61_RS00130	COG2610	gluconate transmembrane transporter activity
C2D61_RS00135	COG0583	DNA-binding transcription factor activity
C2D61_RS00140	COG2814	Major facilitator Superfamily
C2D61_RS00165	COG0028	Belongs to the TPP enzyme family
C2D61_RS00170	COG0440	acetolactate synthase activity
C2D61_RS00175	COG2197	response regulator
C2D61_RS00185	COG2271	Major facilitator Superfamily
C2D61_RS00225	COG2188	Transcriptional regulator
C2D61_RS00250	COG4580	involved in the transport of maltose and maltodextrins
C2D61_RS00255	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D61_RS00260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS00260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS00270	COG1609	Transcriptional regulator
C2D61_RS00280	COG3384	dioxygenase
C2D61_RS00285	COG0583	DNA-binding transcription factor activity
C2D61_RS00290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2D61_RS00295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2D61_RS00300	COG2828	Protein conserved in bacteria
C2D61_RS00315	COG0697	spore germination
C2D61_RS00320	COG1263	PTS System
C2D61_RS00320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS00330	COG2814	Major facilitator Superfamily
C2D61_RS00340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D61_RS00365	COG0583	DNA-binding transcription factor activity
C2D61_RS00390	COG1464	Belongs to the NlpA lipoprotein family
C2D61_RS00405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2D61_RS00415	COG1064	alcohol dehydrogenase
C2D61_RS00475	COG2211	Major facilitator Superfamily
C2D61_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
C2D61_RS00490	COG1486	melibiose metabolic process
C2D61_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS00495	COG1263	PTS System
C2D61_RS00500	COG2982	Protein involved in outer membrane biogenesis
C2D61_RS00505	COG2233	PERMEase
C2D61_RS00510	COG0786	glutamate:sodium symporter activity
C2D61_RS00530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2D61_RS00555	COG3152	Membrane
C2D61_RS00565	COG1494	fructose-1,6-bisphosphatase
C2D61_RS00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2D61_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D61_RS00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2D61_RS00600	COG2860	membrane
C2D61_RS00610	COG2169	Transcriptional regulator
C2D61_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2D61_RS00620	COG1561	YicC-like family, N-terminal region
C2D61_RS00635	COG1131	(ABC) transporter
C2D61_RS00640	COG0842	Transport permease protein
C2D61_RS00665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2D61_RS00700	COG1519	Transferase
C2D61_RS00705	COG1216	Glycosyl transferase, family 2
C2D61_RS00710	COG0438	transferase activity, transferring glycosyl groups
C2D61_RS00720	COG0859	PFAM glycosyl transferase family 9
C2D61_RS00745	COG0859	PFAM glycosyl transferase family 9
C2D61_RS00760	COG0156	8-amino-7-oxononanoate synthase activity
C2D61_RS00770	COG0463	Glycosyl transferase, family 2
C2D61_RS00775	COG2861	carbohydrate metabolic process
C2D61_RS00780	COG4942	peptidase
C2D61_RS00790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2D61_RS00795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2D61_RS00815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2D61_RS00825	COG2186	Transcriptional regulator
C2D61_RS00845	COG3722	fumarate hydratase activity
C2D61_RS00865	COG1566	PFAM secretion protein HlyD family protein
C2D61_RS00870	COG0625	glutathione transferase activity
C2D61_RS00880	COG3276	selenocysteine insertion sequence binding
C2D61_RS00885	COG1414	Transcriptional regulator
C2D61_RS00890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D61_RS00895	COG3977	Valine--pyruvate aminotransferase
C2D61_RS00900	COG0366	Alpha amylase catalytic
C2D61_RS00905	COG2992	FlgJ-related protein
C2D61_RS00910	COG1609	Transcriptional regulator
C2D61_RS00910	COG2207	Transcriptional regulator
C2D61_RS00915	COG4214	carbohydrate transport
C2D61_RS00925	COG4213	ABC transporter substrate-binding protein
C2D61_RS00940	COG4682	membrane
C2D61_RS00945	COG4682	membrane
C2D61_RS00950	COG3274	enterobacterial common antigen metabolic process
C2D61_RS00980	COG1278	Cold shock
C2D61_RS00985	COG2944	sequence-specific DNA binding
C2D61_RS00990	COG2814	Major facilitator Superfamily
C2D61_RS01010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D61_RS01020	COG1609	Transcriptional regulator
C2D61_RS01025	COG2885	chlorophyll binding
C2D61_RS01030	COG0243	molybdopterin cofactor binding
C2D61_RS01035	COG0456	acetyltransferase
C2D61_RS01040	COG2818	Glycosylase
C2D61_RS01045	COG5571	outer membrane autotransporter
C2D61_RS01050	COG2223	nitrite transmembrane transporter activity
C2D61_RS01075	COG0747	negative chemotaxis
C2D61_RS01080	COG0601	transmembrane transport
C2D61_RS01085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D61_RS01090	COG0444	Belongs to the ABC transporter superfamily
C2D61_RS01095	COG4608	Belongs to the ABC transporter superfamily
C2D61_RS01105	COG2894	cell division
C2D61_RS01115	COG1215	transferase activity, transferring glycosyl groups
C2D61_RS01120	COG0457	Tetratricopeptide repeat
C2D61_RS01135	COG2194	sulfuric ester hydrolase activity
C2D61_RS01165	COG1215	transferase activity, transferring glycosyl groups
C2D61_RS01170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2D61_RS01175	COG0457	Tetratricopeptide repeat
C2D61_RS01175	COG3118	belongs to the thioredoxin family
C2D61_RS01180	COG2199	diguanylate cyclase activity
C2D61_RS01180	COG2200	EAL domain
C2D61_RS01190	COG0612	Peptidase, M16
C2D61_RS01205	COG2982	Protein involved in outer membrane biogenesis
C2D61_RS01210	COG0477	Major facilitator Superfamily
C2D61_RS01215	COG1295	ribonuclease BN
C2D61_RS01220	COG0583	DNA-binding transcription factor activity
C2D61_RS01225	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS01230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D61_RS01240	COG1454	alcohol dehydrogenase
C2D61_RS01250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D61_RS01255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2D61_RS01260	COG0671	phosphoesterase, PA-phosphatase related
C2D61_RS01280	COG0589	response to stress
C2D61_RS01290	COG0306	phosphate transporter
C2D61_RS01295	COG2081	HI0933 family
C2D61_RS01300	COG2239	Acts as a magnesium transporter
C2D61_RS01310	COG1124	(ABC) transporter
C2D61_RS01320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D61_RS01325	COG0601	transmembrane transport
C2D61_RS01330	COG0747	negative chemotaxis
C2D61_RS01340	COG3479	Phenolic acid decarboxylase
C2D61_RS01380	COG0628	permease
C2D61_RS01385	COG0477	Major facilitator Superfamily
C2D61_RS01395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2D61_RS01410	COG3714	YhhN family
C2D61_RS01420	COG3776	membrane
C2D61_RS01425	COG0742	ribosomal rna small subunit methyltransferase
C2D61_RS01430	COG0552	protein localization to endoplasmic reticulum
C2D61_RS01435	COG2884	Cell division ATP-binding protein ftsE
C2D61_RS01440	COG2177	Part of the ABC transporter FtsEX involved in
C2D61_RS01455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D61_RS01465	COG0683	leucine binding
C2D61_RS01480	COG0683	leucine binding
C2D61_RS01485	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS01535	COG0584	glycerophosphoryl diester phosphodiesterase
C2D61_RS01545	COG0405	Gamma-glutamyltransferase
C2D61_RS01550	COG1247	-acetyltransferase
C2D61_RS01560	COG0673	inositol 2-dehydrogenase activity
C2D61_RS01565	COG1741	Belongs to the pirin family
C2D61_RS01570	COG1609	Transcriptional regulator
C2D61_RS01575	COG3265	gluconokinase activity
C2D61_RS01580	COG2610	gluconate transmembrane transporter activity
C2D61_RS01590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D61_RS01615	COG0058	SHG alpha-glucan phosphorylase activity
C2D61_RS01630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2D61_RS01645	COG1349	DNA-binding transcription factor activity
C2D61_RS01655	COG0058	SHG alpha-glucan phosphorylase activity
C2D61_RS01660	COG1640	4-alpha-glucanotransferase
C2D61_RS01665	COG2610	gluconate transmembrane transporter activity
C2D61_RS01675	COG1040	competence protein
C2D61_RS01700	COG1918	ferrous iron import across plasma membrane
C2D61_RS01705	COG2183	response to ionizing radiation
C2D61_RS01710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2D61_RS01735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2D61_RS01740	COG1011	Hydrolase
C2D61_RS01750	COG0494	nUDIX hydrolase
C2D61_RS01755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2D61_RS01780	COG4796	Type ii and iii secretion system protein
C2D61_RS01795	COG3266	domain, Protein
C2D61_RS01800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2D61_RS01805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D61_RS01830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2D61_RS01835	COG0402	S-adenosylhomocysteine deaminase activity
C2D61_RS01840	COG0738	Major facilitator superfamily
C2D61_RS01865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2D61_RS01870	COG1289	transmembrane transporter activity
C2D61_RS01880	COG1765	OsmC-like protein
C2D61_RS01885	COG3954	Phosphoribulokinase
C2D61_RS01895	COG0429	hydrolase of the alpha beta-hydrolase fold
C2D61_RS01900	COG0488	(ABC) transporter
C2D61_RS01915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2D61_RS01920	COG1047	Peptidyl-prolyl cis-trans
C2D61_RS01930	COG0545	Peptidyl-prolyl cis-trans isomerase
C2D61_RS01935	COG2964	Protein conserved in bacteria
C2D61_RS01990	COG0051	transcription antitermination factor activity, RNA binding
C2D61_RS02015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2D61_RS02030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2D61_RS02095	COG0201	protein transport
C2D61_RS02120	COG0202	RNA polymerase activity
C2D61_RS02135	COG0789	Transcriptional regulator
C2D61_RS02140	COG3036	rescue of stalled ribosome
C2D61_RS02170	COG0758	DNA mediated transformation
C2D61_RS02180	COG0551	DNA topoisomerase type I activity
C2D61_RS02200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D61_RS02235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D61_RS02240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS02245	COG1309	transcriptional regulator
C2D61_RS02265	COG4145	pantothenate transmembrane transporter activity
C2D61_RS02270	COG3924	membrane
C2D61_RS02275	COG0439	Biotin carboxylase
C2D61_RS02280	COG0511	ligase activity, forming carbon-carbon bonds
C2D61_RS02305	COG2200	EAL domain
C2D61_RS02305	COG2199	diguanylate cyclase activity
C2D61_RS02310	COG1077	Cell shape determining protein MreB Mrl
C2D61_RS02315	COG1792	Involved in formation and maintenance of cell shape
C2D61_RS02320	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2D61_RS02330	COG1530	ribonuclease E activity
C2D61_RS02335	COG3164	Protein of unknown function
C2D61_RS02340	COG0312	modulator of DNA gyrase
C2D61_RS02345	COG0583	DNA-binding transcription factor activity
C2D61_RS02360	COG1289	transmembrane transporter activity
C2D61_RS02365	COG2732	(Barnase) inhibitor
C2D61_RS02400	COG0471	metal ion transport
C2D61_RS02405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D61_RS02410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D61_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D61_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D61_RS02445	COG3105	Protein conserved in bacteria
C2D61_RS02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2D61_RS02470	COG0625	glutathione transferase activity
C2D61_RS02475	COG2969	positive regulation of protein catabolic process
C2D61_RS02485	COG0493	'glutamate synthase
C2D61_RS02490	COG0067	glutamate synthase
C2D61_RS02490	COG0070	glutamate synthase
C2D61_RS02490	COG0069	glutamate synthase activity
C2D61_RS02495	COG1242	4 iron, 4 sulfur cluster binding
C2D61_RS02500	COG2271	Major facilitator Superfamily
C2D61_RS02505	COG1063	alcohol dehydrogenase
C2D61_RS02510	COG1312	Catalyzes the dehydration of D-mannonate
C2D61_RS02515	COG2198	Histidine kinase
C2D61_RS02515	COG0784	Response regulator, receiver
C2D61_RS02515	COG5002	protein histidine kinase activity
C2D61_RS02520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2D61_RS02525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2D61_RS02530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS02540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS02545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2D61_RS02550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2D61_RS02555	COG1137	ATPase activity
C2D61_RS02560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2D61_RS02565	COG3117	lipopolysaccharide transmembrane transporter activity
C2D61_RS02570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2D61_RS02580	COG0530	calcium, potassium:sodium antiporter activity
C2D61_RS02585	COG1127	ABC transporter
C2D61_RS02590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2D61_RS02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2D61_RS02600	COG2854	intermembrane phospholipid transfer
C2D61_RS02605	COG3113	response to antibiotic
C2D61_RS02610	COG5007	Belongs to the BolA IbaG family
C2D61_RS02620	COG3423	Transcriptional regulator
C2D61_RS02625	COG0142	geranyltranstransferase activity
C2D61_RS02640	COG0697	spore germination
C2D61_RS02650	COG2027	D-alanyl-D-alanine carboxypeptidase
C2D61_RS02660	COG1534	Rna-binding protein
C2D61_RS02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2D61_RS02675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2D61_RS02685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2D61_RS02725	COG0195	Participates in both transcription termination and antitermination
C2D61_RS02770	COG0814	amino acid
C2D61_RS02775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D61_RS02780	COG0826	peptidase U32
C2D61_RS02785	COG0826	peptidase U32
C2D61_RS02790	COG3154	lipid carrier protein
C2D61_RS02795	COG3153	acetyltransferase
C2D61_RS02810	COG0693	protein deglycase activity
C2D61_RS02815	COG0702	epimerase
C2D61_RS02820	COG0701	Predicted permease
C2D61_RS02825	COG2823	Periplasmic or secreted lipoprotein
C2D61_RS02845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2D61_RS02850	COG2721	sulfolactate sulfo-lyase activity
C2D61_RS02860	COG2271	Major facilitator Superfamily
C2D61_RS02870	COG2084	Dehydrogenase
C2D61_RS02875	COG1929	Belongs to the glycerate kinase type-1 family
C2D61_RS02895	COG1741	Belongs to the pirin family
C2D61_RS02900	COG0583	DNA-binding transcription factor activity
C2D61_RS02905	COG3152	Membrane
C2D61_RS02910	COG0435	Glutathione S-transferase
C2D61_RS02915	COG2259	Doxx family
C2D61_RS02925	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2D61_RS02930	COG4575	ribosome binding
C2D61_RS02935	COG1422	Protein of unknown function (DUF1090)
C2D61_RS02945	COG0586	Pfam SNARE associated Golgi protein
C2D61_RS02950	COG2186	Transcriptional regulator
C2D61_RS02955	COG2271	Major facilitator Superfamily
C2D61_RS02965	COG2721	sulfolactate sulfo-lyase activity
C2D61_RS02980	COG0861	Integral membrane protein TerC family
C2D61_RS02985	COG0673	inositol 2-dehydrogenase activity
C2D61_RS02990	COG1451	nucleotide metabolic process
C2D61_RS03010	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2D61_RS03010	COG1902	pentaerythritol trinitrate reductase activity
C2D61_RS03060	COG1695	Transcriptional regulator
C2D61_RS03065	COG2375	cellular response to nickel ion
C2D61_RS03080	COG1461	Dihydroxyacetone kinase
C2D61_RS03085	COG2376	Dihydroxyacetone kinase
C2D61_RS03155	COG3247	response to pH
C2D61_RS03165	COG2205	protein histidine kinase activity
C2D61_RS03165	COG2198	Histidine kinase
C2D61_RS03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS03165	COG0784	Response regulator, receiver
C2D61_RS03170	COG2197	response regulator
C2D61_RS03190	COG4974	Belongs to the 'phage' integrase family
C2D61_RS03225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2D61_RS03260	COG4695	Portal protein
C2D61_RS03415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2D61_RS03420	COG0358	DNA primase activity
C2D61_RS03425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2D61_RS03485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2D61_RS03500	COG4991	sh3 domain protein
C2D61_RS03505	COG3025	triphosphatase activity
C2D61_RS03525	COG2960	long-chain fatty acid transporting porin activity
C2D61_RS03540	COG3384	dioxygenase
C2D61_RS03545	COG0754	glutathionylspermidine amidase activity
C2D61_RS03560	COG0494	nUDIX hydrolase
C2D61_RS03565	COG3151	Protein conserved in bacteria
C2D61_RS03570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2D61_RS03575	COG3150	esterase
C2D61_RS03585	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2D61_RS03590	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2D61_RS03595	COG0642	Histidine kinase
C2D61_RS03605	COG3111	PFAM Bacterial OB fold (BOF) protein
C2D61_RS03610	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2D61_RS03615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2D61_RS03620	COG0204	Acyl-transferase
C2D61_RS03625	COG2132	Multicopper oxidase
C2D61_RS03630	COG1032	radical SAM domain protein
C2D61_RS03640	COG0656	L-ascorbic acid biosynthetic process
C2D61_RS03645	COG1979	alcohol dehydrogenase
C2D61_RS03650	COG2207	Transcriptional regulator
C2D61_RS03655	COG0586	Pfam SNARE associated Golgi protein
C2D61_RS03660	COG0626	cystathionine gamma-synthase activity
C2D61_RS03675	COG0848	biopolymer transport protein
C2D61_RS03680	COG2211	Major facilitator Superfamily
C2D61_RS03705	COG0625	glutathione transferase activity
C2D61_RS03720	COG0754	glutathionylspermidine amidase activity
C2D61_RS03725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D61_RS03745	COG0583	DNA-binding transcription factor activity
C2D61_RS03750	COG0626	cystathionine gamma-synthase activity
C2D61_RS03765	COG1811	Na channel or pump
C2D61_RS03770	COG1982	Orn Lys Arg decarboxylase major
C2D61_RS03775	COG2211	Major facilitator Superfamily
C2D61_RS03790	COG1194	a g-specific adenine glycosylase
C2D61_RS03800	COG3171	Protein conserved in bacteria
C2D61_RS03810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2D61_RS03825	COG0762	integral membrane protein
C2D61_RS03830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2D61_RS03835	COG2805	Type II/IV secretion system protein
C2D61_RS03855	COG0189	ligase activity
C2D61_RS03860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2D61_RS03865	COG2356	endonuclease I
C2D61_RS03875	COG2814	Major facilitator Superfamily
C2D61_RS03910	COG2146	nitrite reductase [NAD(P)H] activity
C2D61_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS03930	COG1414	Transcriptional regulator
C2D61_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS03965	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C2D61_RS03985	COG0501	Belongs to the peptidase M48B family
C2D61_RS03990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D61_RS04005	COG0191	fructose-bisphosphate aldolase activity
C2D61_RS04010	COG0668	transmembrane transport
C2D61_RS04020	COG2968	Membrane
C2D61_RS04035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D61_RS04040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2D61_RS04060	COG0006	proline dipeptidase activity
C2D61_RS04065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D61_RS04070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D61_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS04100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2D61_RS04120	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS04125	COG1737	Transcriptional regulator
C2D61_RS04135	COG1272	protein, Hemolysin III
C2D61_RS04145	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2D61_RS04155	COG0716	FMN binding
C2D61_RS04160	COG4974	Belongs to the 'phage' integrase family
C2D61_RS04170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2D61_RS04190	COG4942	peptidase
C2D61_RS04200	COG2814	Major facilitator Superfamily
C2D61_RS04215	COG0667	Aldo Keto reductase
C2D61_RS04255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2D61_RS04260	COG1393	Belongs to the ArsC family
C2D61_RS04275	COG1538	Outer membrane efflux protein
C2D61_RS04280	COG1289	transmembrane transporter activity
C2D61_RS04295	COG3592	Divergent 4Fe-4S mono-cluster
C2D61_RS04300	COG2388	GCN5-related N-acetyl-transferase
C2D61_RS04310	COG3539	Fimbrial protein
C2D61_RS04315	COG3539	Fimbrial protein
C2D61_RS04320	COG3539	Fimbrial protein
C2D61_RS04325	COG3188	usher protein
C2D61_RS04330	COG3121	Chaperone
C2D61_RS04335	COG3539	Fimbrial protein
C2D61_RS04345	COG4974	Belongs to the 'phage' integrase family
C2D61_RS04350	COG0582	viral genome integration into host DNA
C2D61_RS04355	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D61_RS04360	COG1846	Transcriptional regulator
C2D61_RS04365	COG0697	spore germination
C2D61_RS04415	COG0667	Aldo Keto reductase
C2D61_RS04420	COG0814	amino acid
C2D61_RS04435	COG0183	Belongs to the thiolase family
C2D61_RS04445	COG0823	Involved in the tonB-independent uptake of proteins
C2D61_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS04455	COG2814	Major facilitator Superfamily
C2D61_RS04465	COG2223	nitrite transmembrane transporter activity
C2D61_RS04485	COG3842	ATPase activity
C2D61_RS04490	COG0395	ABC-type sugar transport system, permease component
C2D61_RS04495	COG1175	transmembrane transport
C2D61_RS04500	COG1917	Cupin 2, conserved barrel domain protein
C2D61_RS04505	COG1794	racemase activity, acting on amino acids and derivatives
C2D61_RS04510	COG0583	DNA-binding transcription factor activity
C2D61_RS04520	COG1609	Transcriptional regulator
C2D61_RS04525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS04530	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS04535	COG2186	Transcriptional regulator
C2D61_RS04545	COG1609	Transcriptional regulator
C2D61_RS04560	COG0667	Aldo Keto reductase
C2D61_RS04570	COG0861	Integral membrane protein TerC family
C2D61_RS04600	COG2165	general secretion pathway protein
C2D61_RS04605	COG4795	General secretion pathway protein
C2D61_RS04615	COG4967	type IV pilus modification protein PilV
C2D61_RS04620	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2D61_RS04625	COG1025	Belongs to the peptidase M16 family
C2D61_RS04630	COG1074	ATP-dependent DNA helicase activity
C2D61_RS04635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2D61_RS04645	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2D61_RS04645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2D61_RS04650	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D61_RS04655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2D61_RS04685	COG4656	Part of a membrane complex involved in electron transport
C2D61_RS04690	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS04690	COG1454	alcohol dehydrogenase
C2D61_RS04720	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2D61_RS04885	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2D61_RS04890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2D61_RS04895	COG2166	iron-sulfur cluster assembly
C2D61_RS04900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2D61_RS04910	COG0583	DNA-binding transcription factor activity
C2D61_RS04915	COG2363	Small membrane protein
C2D61_RS04925	COG1349	DNA-binding transcription factor activity
C2D61_RS04945	COG0738	Major facilitator superfamily
C2D61_RS04950	COG0235	Class ii aldolase
C2D61_RS04955	COG1454	alcohol dehydrogenase
C2D61_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D61_RS04985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2D61_RS04990	COG2011	ABC-type metal ion transport system permease component
C2D61_RS04995	COG1464	Belongs to the NlpA lipoprotein family
C2D61_RS05000	COG0477	Major facilitator Superfamily
C2D61_RS05010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D61_RS05015	COG1760	l-serine dehydratase
C2D61_RS05020	COG0814	amino acid
C2D61_RS05025	COG1611	Belongs to the LOG family
C2D61_RS05040	COG3098	single-species biofilm formation
C2D61_RS05045	COG0564	pseudouridine synthase activity
C2D61_RS05050	COG0716	FMN binding
C2D61_RS05055	COG2271	Major facilitator Superfamily
C2D61_RS05060	COG4948	Mandelate Racemase Muconate Lactonizing
C2D61_RS05065	COG4948	Mandelate Racemase Muconate Lactonizing
C2D61_RS05070	COG1929	Belongs to the glycerate kinase type-1 family
C2D61_RS05080	COG2205	protein histidine kinase activity
C2D61_RS05080	COG4999	Histidine kinase
C2D61_RS05080	COG3437	response regulator, receiver
C2D61_RS05080	COG3850	Histidine kinase
C2D61_RS05090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2D61_RS05095	COG3956	TIGRFAM MazG family protein
C2D61_RS05115	COG0602	queuosine metabolic process
C2D61_RS05120	COG0720	synthase
C2D61_RS05140	COG1203	CRISPR-associated helicase, Cas3
C2D61_RS05155	COG1857	crispr-associated protein
C2D61_RS05170	COG1518	maintenance of DNA repeat elements
C2D61_RS05175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D61_RS05190	COG2234	aminopeptidase activity
C2D61_RS05250	COG1388	LysM domain
C2D61_RS05250	COG4942	peptidase
C2D61_RS05255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2D61_RS05280	COG0163	prenyltransferase activity
C2D61_RS05285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2D61_RS05325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS05330	COG4558	Periplasmic binding protein
C2D61_RS05335	COG3720	iron ion transport
C2D61_RS05355	COG0679	Auxin Efflux Carrier
C2D61_RS05370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D61_RS05375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D61_RS05380	COG1121	(ABC) transporter
C2D61_RS05385	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2D61_RS05390	COG1609	Transcriptional regulator
C2D61_RS05395	COG1940	carbohydrate kinase activity
C2D61_RS05400	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D61_RS05405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS05410	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS05415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS05420	COG4580	involved in the transport of maltose and maltodextrins
C2D61_RS05430	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS05440	COG0309	Hydrogenase expression formation protein (HypE)
C2D61_RS05445	COG0409	Hydrogenase expression formation protein
C2D61_RS05450	COG0298	carbon dioxide binding
C2D61_RS05455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2D61_RS05470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D61_RS05475	COG0651	ATP synthesis coupled electron transport
C2D61_RS05480	COG0650	Formate hydrogenlyase subunit 4
C2D61_RS05485	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2D61_RS05485	COG3261	NADH dehydrogenase
C2D61_RS05490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D61_RS05495	COG3260	NADH ubiquinone oxidoreductase 20
C2D61_RS05505	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2D61_RS05515	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS05520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS05520	COG1263	PTS System
C2D61_RS05525	COG1609	Transcriptional regulator
C2D61_RS05530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D61_RS05535	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2D61_RS05540	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D61_RS05565	COG1349	DNA-binding transcription factor activity
C2D61_RS05570	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS05585	COG3732	PTS system glucitol sorbitol-specific
C2D61_RS05590	COG3730	PTS system glucitol sorbitol-specific
C2D61_RS05595	COG2951	lytic endotransglycosylase activity
C2D61_RS05605	COG1121	(ABC) transporter
C2D61_RS05610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D61_RS05615	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2D61_RS05620	COG1546	Belongs to the CinA family
C2D61_RS05640	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2D61_RS05670	COG2823	Periplasmic or secreted lipoprotein
C2D61_RS05675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D61_RS05680	COG1238	metal cluster binding
C2D61_RS05700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2D61_RS05705	COG2814	Major facilitator Superfamily
C2D61_RS05710	COG1566	PFAM secretion protein HlyD family protein
C2D61_RS05715	COG1846	Transcriptional regulator
C2D61_RS05725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2D61_RS05735	COG4176	ABC-type proline glycine betaine transport system permease component
C2D61_RS05750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2D61_RS05760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2D61_RS05765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D61_RS05770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D61_RS05775	COG4575	ribosome binding
C2D61_RS05790	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D61_RS05805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2D61_RS05810	COG0640	Transcriptional regulator
C2D61_RS05820	COG0583	DNA-binding transcription factor activity
C2D61_RS05825	COG3284	Transcriptional regulator
C2D61_RS05835	COG3539	Fimbrial protein
C2D61_RS05840	COG3121	Chaperone
C2D61_RS05855	COG3121	Chaperone
C2D61_RS05875	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS05885	COG0235	Class ii aldolase
C2D61_RS05890	COG1126	abc transporter atp-binding protein
C2D61_RS05895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS05930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS05935	COG3708	Transcriptional regulator
C2D61_RS05935	COG2207	Transcriptional regulator
C2D61_RS05965	COG2867	negative regulation of translational initiation
C2D61_RS05980	COG0497	DNA recombination
C2D61_RS05995	COG4536	flavin adenine dinucleotide binding
C2D61_RS06000	COG4137	Cytochrome C assembly protein
C2D61_RS06005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2D61_RS06040	COG2885	chlorophyll binding
C2D61_RS06045	COG2199	diguanylate cyclase activity
C2D61_RS06055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D61_RS06060	COG1605	Chorismate mutase
C2D61_RS06060	COG0287	Prephenate dehydrogenase
C2D61_RS06070	COG1605	Chorismate mutase
C2D61_RS06070	COG0077	Prephenate dehydratase
C2D61_RS06080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2D61_RS06085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D61_RS06100	COG0542	response to heat
C2D61_RS06125	COG0477	Major facilitator Superfamily
C2D61_RS06130	COG5544	Lipoprotein
C2D61_RS06135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2D61_RS06145	COG3148	PFAM DTW domain containing protein
C2D61_RS06150	COG3118	belongs to the thioredoxin family
C2D61_RS06155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D61_RS06170	COG0513	Belongs to the DEAD box helicase family
C2D61_RS06180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2D61_RS06195	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2D61_RS06200	COG3026	antisigma factor binding
C2D61_RS06205	COG3086	response to oxidative stress
C2D61_RS06215	COG0681	Belongs to the peptidase S26 family
C2D61_RS06235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2D61_RS06245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D61_RS06250	COG1737	Transcriptional regulator
C2D61_RS06255	COG0560	Phosphoserine phosphatase
C2D61_RS06270	COG0047	phosphoribosylformylglycinamidine synthase activity
C2D61_RS06270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2D61_RS06275	COG2205	protein histidine kinase activity
C2D61_RS06280	COG3170	Tfp pilus assembly protein FimV
C2D61_RS06285	COG2204	response regulator
C2D61_RS06290	COG0347	Belongs to the P(II) protein family
C2D61_RS06295	COG1017	nitric oxide dioxygenase activity
C2D61_RS06295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D61_RS06305	COG2259	Doxx family
C2D61_RS06310	COG1940	carbohydrate kinase activity
C2D61_RS06315	COG0457	Tetratricopeptide repeat
C2D61_RS06320	COG0477	Major facilitator Superfamily
C2D61_RS06320	COG2814	Major facilitator Superfamily
C2D61_RS06325	COG2017	converts alpha-aldose to the beta-anomer
C2D61_RS06330	COG2814	Major facilitator Superfamily
C2D61_RS06335	COG3711	transcriptional antiterminator
C2D61_RS06340	COG3683	transport system, periplasmic component
C2D61_RS06345	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D61_RS06375	COG0822	iron-sulfur transferase activity
C2D61_RS06395	COG0633	Ferredoxin
C2D61_RS06400	COG2975	iron-sulfur cluster assembly
C2D61_RS06420	COG2897	thiosulfate sulfurtransferase activity
C2D61_RS06425	COG2373	Large extracellular alpha-helical protein
C2D61_RS06430	COG4953	penicillin-binding protein 1C
C2D61_RS06460	COG2976	Protein conserved in bacteria
C2D61_RS06480	COG1645	bacterial-type flagellum-dependent swarming motility
C2D61_RS06490	COG0517	IMP dehydrogenase activity
C2D61_RS06490	COG0516	GMP reductase activity
C2D61_RS06500	COG3119	arylsulfatase activity
C2D61_RS06505	COG0641	radical SAM
C2D61_RS06525	COG2200	EAL domain
C2D61_RS06540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2D61_RS06555	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS06565	COG2233	PERMEase
C2D61_RS06580	COG1393	Belongs to the ArsC family
C2D61_RS06585	COG4783	chaperone-mediated protein folding
C2D61_RS06590	COG0628	permease
C2D61_RS06595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2D61_RS06600	COG2716	regulation of RNA biosynthetic process
C2D61_RS06610	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2D61_RS06620	COG2321	neutral zinc metallopeptidase
C2D61_RS06625	COG1444	tRNA N-acetyltransferase activity
C2D61_RS06630	COG0400	carboxylic ester hydrolase activity
C2D61_RS06645	COG1393	Belongs to the ArsC family
C2D61_RS06655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D61_RS06660	COG0493	'glutamate synthase
C2D61_RS06660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D61_RS06670	COG5342	invasion associated locus B
C2D61_RS06675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D61_RS06680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D61_RS06690	COG4810	utilization protein
C2D61_RS06780	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D61_RS06800	COG2837	iron assimilation
C2D61_RS06810	COG4150	thiosulfate binding
C2D61_RS06815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2D61_RS06820	COG4208	sulfate ABC transporter
C2D61_RS06825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2D61_RS06835	COG4319	ketosteroid isomerase
C2D61_RS06870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2D61_RS06890	COG3530	Putative quorum-sensing-regulated virulence factor
C2D61_RS06895	COG0385	Bile acid
C2D61_RS06900	COG0583	DNA-binding transcription factor activity
C2D61_RS06930	COG3415	Transposase
C2D61_RS06935	COG3415	Transposase
C2D61_RS06955	COG2199	diguanylate cyclase activity
C2D61_RS06955	COG2200	EAL domain
C2D61_RS06960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D61_RS06975	COG0667	Aldo Keto reductase
C2D61_RS06980	COG3961	Belongs to the TPP enzyme family
C2D61_RS06995	COG3279	Response regulator of the LytR AlgR family
C2D61_RS07000	COG3275	phosphorelay sensor kinase activity
C2D61_RS07005	COG0436	Aminotransferase
C2D61_RS07015	COG2807	transmembrane transport
C2D61_RS07020	COG0590	tRNA wobble adenosine to inosine editing
C2D61_RS07025	COG0583	DNA-binding transcription factor activity
C2D61_RS07060	COG2814	Major facilitator Superfamily
C2D61_RS07065	COG4221	oxidoreductase activity
C2D61_RS07070	COG2171	N-acyltransferase activity
C2D61_RS07125	COG1122	ATPase activity
C2D61_RS07160	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS07160	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS07165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS07165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS07170	COG3715	PTS system
C2D61_RS07175	COG3716	PTS system mannose fructose sorbose family IID component
C2D61_RS07190	COG2376	Dihydroxyacetone kinase
C2D61_RS07195	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2D61_RS07200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2D61_RS07230	COG3121	Chaperone
C2D61_RS07235	COG3188	usher protein
C2D61_RS07255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2D61_RS07275	COG2116	formate transmembrane transporter activity
C2D61_RS07280	COG2853	Lipoprotein
C2D61_RS07290	COG3691	Protein conserved in bacteria
C2D61_RS07305	COG2062	phosphohistidine phosphatase, SixA
C2D61_RS07330	COG0730	response to heat
C2D61_RS07335	COG3101	peptidyl-lysine hydroxylation
C2D61_RS07350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D61_RS07370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D61_RS07380	COG0586	Pfam SNARE associated Golgi protein
C2D61_RS07390	COG0285	dihydrofolate synthase activity
C2D61_RS07395	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2D61_RS07400	COG1286	toxin biosynthetic process
C2D61_RS07405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2D61_RS07410	COG3829	transcription factor binding
C2D61_RS07420	COG0531	amino acid
C2D61_RS07425	COG3457	Alanine racemase
C2D61_RS07430	COG0833	amino acid
C2D61_RS07435	COG0163	prenyltransferase activity
C2D61_RS07455	COG4160	amino acid transport
C2D61_RS07460	COG4598	ABC transporter
C2D61_RS07470	COG1090	epimerase
C2D61_RS07475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2D61_RS07480	COG0625	glutathione transferase activity
C2D61_RS07485	COG0625	glutathione transferase activity
C2D61_RS07490	COG0622	Phosphoesterase
C2D61_RS07495	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2D61_RS07500	COG0280	phosphate acetyltransferase
C2D61_RS07500	COG0857	belongs to the CobB CobQ family
C2D61_RS07520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D61_RS07525	COG0490	domain, Protein
C2D61_RS07525	COG0471	metal ion transport
C2D61_RS07535	COG0436	Aminotransferase
C2D61_RS07540	COG0583	DNA-binding transcription factor activity
C2D61_RS07585	COG0839	Belongs to the complex I subunit 6 family
C2D61_RS07595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2D61_RS07600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D61_RS07615	COG2153	protein acetylation
C2D61_RS07620	COG1169	isochorismate synthase
C2D61_RS07645	COG0318	PFAM AMP-dependent synthetase and ligase
C2D61_RS07655	COG5464	transposase or invertase
C2D61_RS07670	COG1414	Transcriptional regulator
C2D61_RS07680	COG2271	Major facilitator Superfamily
C2D61_RS07690	COG0247	lactate metabolic process
C2D61_RS07700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2D61_RS07710	COG0584	glycerophosphoryl diester phosphodiesterase
C2D61_RS07715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D61_RS07740	COG2205	protein histidine kinase activity
C2D61_RS07740	COG0784	Response regulator, receiver
C2D61_RS07750	COG2198	Histidine kinase
C2D61_RS07750	COG0642	Histidine kinase
C2D61_RS07765	COG2169	Transcriptional regulator
C2D61_RS07765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2D61_RS07770	COG3145	DNA-N1-methyladenine dioxygenase activity
C2D61_RS07775	COG4615	Cyclic peptide transporter
C2D61_RS07780	COG2239	Acts as a magnesium transporter
C2D61_RS07785	COG0659	secondary active sulfate transmembrane transporter activity
C2D61_RS07800	COG0628	permease
C2D61_RS07825	COG1349	DNA-binding transcription factor activity
C2D61_RS07830	COG0494	nUDIX hydrolase
C2D61_RS07850	COG1061	Type III restriction enzyme res subunit
C2D61_RS07855	COG1187	pseudouridine synthase activity
C2D61_RS07860	COG2814	Major facilitator Superfamily
C2D61_RS07870	COG4172	Belongs to the ABC transporter superfamily
C2D61_RS07875	COG4239	(ABC) transporter, permease
C2D61_RS07880	COG4174	ABC transporter (Permease)
C2D61_RS07885	COG4166	transmembrane transport
C2D61_RS07890	COG2200	EAL domain
C2D61_RS07895	COG0791	NLP P60 protein
C2D61_RS07900	COG0671	phosphoesterase, PA-phosphatase related
C2D61_RS07905	COG0523	cobalamin synthesis protein
C2D61_RS07910	COG0246	Mannitol dehydrogenase
C2D61_RS07915	COG1312	Catalyzes the dehydration of D-mannonate
C2D61_RS07940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS07940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS07945	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D61_RS07950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D61_RS07950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D61_RS07950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2D61_RS07960	COG2855	membrane
C2D61_RS07965	COG0583	DNA-binding transcription factor activity
C2D61_RS07970	COG0833	amino acid
C2D61_RS07975	COG4771	TonB-dependent receptor
C2D61_RS07990	COG2311	Membrane
C2D61_RS08005	COG1129	ABC transporter
C2D61_RS08015	COG2949	membrane
C2D61_RS08025	COG1346	cytolysis
C2D61_RS08035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2D61_RS08040	COG3659	wide pore channel activity
C2D61_RS08055	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS08060	COG1538	Outer membrane efflux protein
C2D61_RS08065	COG0586	Pfam SNARE associated Golgi protein
C2D61_RS08075	COG1686	Belongs to the peptidase S11 family
C2D61_RS08085	COG0277	FAD linked oxidase domain protein
C2D61_RS08090	COG1472	Belongs to the glycosyl hydrolase 3 family
C2D61_RS08095	COG1732	Glycine betaine
C2D61_RS08100	COG1174	glycine betaine transport
C2D61_RS08105	COG1125	glycine betaine transport
C2D61_RS08110	COG1174	glycine betaine transport
C2D61_RS08120	COG3275	phosphorelay sensor kinase activity
C2D61_RS08130	COG4807	Protein conserved in bacteria
C2D61_RS08150	COG5455	response to cobalt ion
C2D61_RS08155	COG0583	DNA-binding transcription factor activity
C2D61_RS08160	COG2252	PERMEase
C2D61_RS08170	COG0583	DNA-binding transcription factor activity
C2D61_RS08185	COG0351	phosphomethylpyrimidine kinase
C2D61_RS08190	COG1830	Aldolase
C2D61_RS08200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2D61_RS08225	COG1070	Carbohydrate kinase
C2D61_RS08235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D61_RS08245	COG0826	peptidase U32
C2D61_RS08250	COG0745	RESPONSE REGULATOR receiver
C2D61_RS08255	COG2205	protein histidine kinase activity
C2D61_RS08280	COG1301	dicarboxylic acid transport
C2D61_RS08300	COG5002	protein histidine kinase activity
C2D61_RS08305	COG0443	Heat shock 70 kDa protein
C2D61_RS08310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2D61_RS08325	COG2982	Protein involved in outer membrane biogenesis
C2D61_RS08330	COG1253	flavin adenine dinucleotide binding
C2D61_RS08365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2D61_RS08375	COG1216	Glycosyl transferase, family 2
C2D61_RS08405	COG2327	Polysaccharide pyruvyl transferase
C2D61_RS08410	COG0463	Glycosyl transferase, family 2
C2D61_RS08480	COG4372	Transposase
C2D61_RS08485	COG3436	PFAM IS66 Orf2 family protein
C2D61_RS08510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2D61_RS08540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D61_RS08545	COG0583	DNA-binding transcription factor activity
C2D61_RS08555	COG0531	amino acid
C2D61_RS08560	COG0640	Transcriptional regulator
C2D61_RS08565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2D61_RS08570	COG2925	Exonuclease
C2D61_RS08580	COG3344	reverse transcriptase
C2D61_RS08590	COG1289	transmembrane transporter activity
C2D61_RS08610	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2D61_RS08620	COG1942	4-Oxalocrotonate Tautomerase
C2D61_RS08625	COG0583	DNA-binding transcription factor activity
C2D61_RS08630	COG0095	Lipoate-protein ligase
C2D61_RS08635	COG0477	Major facilitator Superfamily
C2D61_RS08645	COG3300	MHYT domain
C2D61_RS08645	COG5001	Diguanylate cyclase
C2D61_RS08655	COG3615	Tellurite resistance protein tehB
C2D61_RS08680	COG3706	GGDEF domain
C2D61_RS08700	COG0534	Mate efflux family protein
C2D61_RS08710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2D61_RS08730	COG0604	alcohol dehydrogenase
C2D61_RS08735	COG1309	transcriptional regulator
C2D61_RS08740	COG0025	NhaP-type Na H and K H
C2D61_RS08790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D61_RS08800	COG1418	mRNA catabolic process
C2D61_RS08805	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2D61_RS08810	COG3727	T/G mismatch-specific endonuclease activity
C2D61_RS08815	COG0697	spore germination
C2D61_RS08820	COG2354	Protein conserved in bacteria
C2D61_RS08850	COG0366	Alpha amylase catalytic
C2D61_RS08855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS08865	COG0765	amino acid transport
C2D61_RS08870	COG1126	abc transporter atp-binding protein
C2D61_RS08875	COG2197	response regulator
C2D61_RS08885	COG2197	response regulator
C2D61_RS08920	COG3318	Belongs to the UPF0149 family
C2D61_RS08920	COG3012	SEC-C Motif Domain Protein
C2D61_RS08925	COG0814	amino acid
C2D61_RS08935	COG1528	Iron-storage protein
C2D61_RS08945	COG0477	Major facilitator Superfamily
C2D61_RS08955	COG2211	Major facilitator Superfamily
C2D61_RS08960	COG1528	Iron-storage protein
C2D61_RS08965	COG1879	ABC-type sugar transport system periplasmic component
C2D61_RS08975	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS09000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2D61_RS09010	COG3102	Protein conserved in bacteria
C2D61_RS09030	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2D61_RS09035	COG1801	Protein of unknown function DUF72
C2D61_RS09040	COG1335	isochorismatase
C2D61_RS09050	COG0494	nUDIX hydrolase
C2D61_RS09075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D61_RS09085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2D61_RS09090	COG0739	heme binding
C2D61_RS09095	COG1560	Kdo2-lipid A biosynthetic process
C2D61_RS09105	COG1737	Transcriptional regulator
C2D61_RS09110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2D61_RS09115	COG0129	dihydroxy-acid dehydratase activity
C2D61_RS09120	COG0800	Aldolase
C2D61_RS09130	COG3141	response to X-ray
C2D61_RS09135	COG2979	Protein of unknown function (DUF533)
C2D61_RS09140	COG1770	oligopeptidase
C2D61_RS09145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D61_RS09155	COG2372	response to copper ion
C2D61_RS09160	COG1276	copper resistance
C2D61_RS09175	COG2990	Protein conserved in bacteria
C2D61_RS09200	COG3008	intermembrane lipid transfer
C2D61_RS09205	COG2995	paraquat-inducible protein a
C2D61_RS09210	COG1956	GAF domain-containing protein
C2D61_RS09230	COG2814	Major facilitator Superfamily
C2D61_RS09235	COG1414	Transcriptional regulator
C2D61_RS09265	COG0768	penicillin binding
C2D61_RS09270	COG2226	methyltransferase
C2D61_RS09285	COG3716	PTS system mannose fructose sorbose family IID component
C2D61_RS09290	COG3715	PTS system
C2D61_RS09295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS09295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS09300	COG1253	flavin adenine dinucleotide binding
C2D61_RS09305	COG2200	EAL domain
C2D61_RS09310	COG1760	l-serine dehydratase
C2D61_RS09330	COG0251	oxidation-reduction process
C2D61_RS09335	COG1199	ATP-dependent helicase activity
C2D61_RS09345	COG3065	identical protein binding
C2D61_RS09355	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2D61_RS09365	COG2894	cell division
C2D61_RS09380	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2D61_RS09410	COG2719	SpoVR family
C2D61_RS09430	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2D61_RS09440	COG4774	siderophore transport
C2D61_RS09455	COG2308	Evidence 4 Homologs of previously reported genes of
C2D61_RS09490	COG0583	DNA-binding transcription factor activity
C2D61_RS09495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2D61_RS09510	COG1882	Formate acetyltransferase
C2D61_RS09540	COG0583	DNA-binding transcription factor activity
C2D61_RS09570	COG0583	DNA-binding transcription factor activity
C2D61_RS09585	COG3122	Protein conserved in bacteria
C2D61_RS09610	COG2885	chlorophyll binding
C2D61_RS09675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2D61_RS09760	COG0012	GTP binding
C2D61_RS09780	COG0659	secondary active sulfate transmembrane transporter activity
C2D61_RS09810	COG2890	protein-(glutamine-N5) methyltransferase activity
C2D61_RS09830	COG0387	Pfam Sodium calcium exchanger
C2D61_RS09835	COG4572	Cation transport regulator
C2D61_RS09840	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2D61_RS09850	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2D61_RS09855	COG3707	response regulator
C2D61_RS09860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D61_RS09870	COG1116	anion transmembrane transporter activity
C2D61_RS09875	COG2146	nitrite reductase [NAD(P)H] activity
C2D61_RS09875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2D61_RS09880	COG0243	molybdopterin cofactor binding
C2D61_RS09885	COG4932	domain protein
C2D61_RS09890	COG2197	response regulator
C2D61_RS09895	COG3850	Histidine kinase
C2D61_RS09900	COG2223	nitrite transmembrane transporter activity
C2D61_RS09905	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2D61_RS09910	COG1140	nitrate reductase beta subunit
C2D61_RS09915	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2D61_RS09920	COG2181	nitrate reductase activity
C2D61_RS09930	COG1522	sequence-specific DNA binding
C2D61_RS09955	COG0788	formyltetrahydrofolate deformylase activity
C2D61_RS09965	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2D61_RS09970	COG0745	RESPONSE REGULATOR receiver
C2D61_RS09975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2D61_RS09980	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D61_RS09985	COG1435	thymidine kinase activity
C2D61_RS09990	COG1454	alcohol dehydrogenase
C2D61_RS09990	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS09995	COG2095	MarC family integral membrane protein
C2D61_RS10000	COG4166	transmembrane transport
C2D61_RS10005	COG0601	transmembrane transport
C2D61_RS10010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D61_RS10015	COG0444	Belongs to the ABC transporter superfamily
C2D61_RS10025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2D61_RS10045	COG2353	YceI-like domain
C2D61_RS10050	COG2350	Protein conserved in bacteria
C2D61_RS10060	COG3001	Fructosamine kinase
C2D61_RS10070	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D61_RS10075	COG3137	Salt-induced outer membrane protein
C2D61_RS10115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2D61_RS10115	COG0072	phenylalanine-tRNA ligase activity
C2D61_RS10135	COG0583	DNA-binding transcription factor activity
C2D61_RS10155	COG0386	Belongs to the glutathione peroxidase family
C2D61_RS10165	COG0791	NLP P60 protein
C2D61_RS10175	COG4256	Hemin uptake protein
C2D61_RS10180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D61_RS10190	COG0574	Belongs to the PEP-utilizing enzyme family
C2D61_RS10190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2D61_RS10200	COG0628	permease
C2D61_RS10205	COG0247	lactate metabolic process
C2D61_RS10205	COG0277	FAD linked oxidase domain protein
C2D61_RS10210	COG2050	protein possibly involved in aromatic compounds catabolism
C2D61_RS10215	COG2261	transglycosylase associated protein
C2D61_RS10240	COG1120	ATPase activity
C2D61_RS10245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS10255	COG0583	DNA-binding transcription factor activity
C2D61_RS10280	COG1304	FMN binding
C2D61_RS10285	COG1309	transcriptional regulator
C2D61_RS10300	COG0316	Belongs to the HesB IscA family
C2D61_RS10305	COG0719	Fe-S assembly protein
C2D61_RS10310	COG0396	ATPase activity
C2D61_RS10315	COG0719	Fe-S assembly protein
C2D61_RS10330	COG1376	ErfK ybiS ycfS ynhG family protein
C2D61_RS10355	COG1309	transcriptional regulator
C2D61_RS10360	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2D61_RS10360	COG1082	Xylose isomerase domain protein TIM barrel
C2D61_RS10365	COG2271	Major facilitator Superfamily
C2D61_RS10370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2D61_RS10380	COG1120	ATPase activity
C2D61_RS10385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS10390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2D61_RS10395	COG1414	Transcriptional regulator
C2D61_RS10430	COG2814	Major facilitator Superfamily
C2D61_RS10450	COG0583	DNA-binding transcription factor activity
C2D61_RS10455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D61_RS10475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D61_RS10480	COG1116	anion transmembrane transporter activity
C2D61_RS10485	COG4774	siderophore transport
C2D61_RS10490	COG1120	ATPase activity
C2D61_RS10495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS10500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS10520	COG0765	amino acid transport
C2D61_RS10525	COG1126	abc transporter atp-binding protein
C2D61_RS10555	COG1473	amidohydrolase
C2D61_RS10560	COG3383	formate dehydrogenase (NAD+) activity
C2D61_RS10565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2D61_RS10575	COG1175	transmembrane transport
C2D61_RS10605	COG4133	protoheme IX ABC transporter activity
C2D61_RS10610	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2D61_RS10615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2D61_RS10630	COG1138	Cytochrome C-type biogenesis protein
C2D61_RS10635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2D61_RS10640	COG3088	subunit of a heme lyase
C2D61_RS10640	COG4235	cytochrome complex assembly
C2D61_RS10660	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2D61_RS10675	COG3850	Histidine kinase
C2D61_RS10675	COG5002	protein histidine kinase activity
C2D61_RS10680	COG0745	RESPONSE REGULATOR receiver
C2D61_RS10690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D61_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS10730	COG2610	gluconate transmembrane transporter activity
C2D61_RS10735	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2D61_RS10745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2D61_RS10755	COG0583	DNA-binding transcription factor activity
C2D61_RS10785	COG2814	Major facilitator Superfamily
C2D61_RS10800	COG0277	FAD linked oxidase domain protein
C2D61_RS10805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D61_RS10830	COG0402	S-adenosylhomocysteine deaminase activity
C2D61_RS10870	COG3321	synthase
C2D61_RS10870	COG0604	alcohol dehydrogenase
C2D61_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS10900	COG4608	Belongs to the ABC transporter superfamily
C2D61_RS10905	COG0444	Belongs to the ABC transporter superfamily
C2D61_RS10930	COG0346	lactoylglutathione lyase activity
C2D61_RS10935	COG1349	DNA-binding transcription factor activity
C2D61_RS10965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2D61_RS11020	COG0307	riboflavin synthase, alpha
C2D61_RS11025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2D61_RS11030	COG2814	Major facilitator Superfamily
C2D61_RS11035	COG0583	DNA-binding transcription factor activity
C2D61_RS11050	COG2814	Major facilitator Superfamily
C2D61_RS11065	COG0791	NLP P60 protein
C2D61_RS11070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2D61_RS11080	COG0346	lactoylglutathione lyase activity
C2D61_RS11085	COG1902	pentaerythritol trinitrate reductase activity
C2D61_RS11090	COG1309	transcriptional regulator
C2D61_RS11095	COG3313	Fe-S protein
C2D61_RS11100	COG4989	oxidoreductase activity
C2D61_RS11105	COG2032	superoxide dismutase activity
C2D61_RS11110	COG1289	transmembrane transporter activity
C2D61_RS11115	COG1566	PFAM secretion protein HlyD family protein
C2D61_RS11130	COG3706	GGDEF domain
C2D61_RS11145	COG3895	Periplasmic Protein
C2D61_RS11160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2D61_RS11165	COG0625	glutathione transferase activity
C2D61_RS11175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2D61_RS11185	COG4659	FMN binding
C2D61_RS11220	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS11230	COG0673	inositol 2-dehydrogenase activity
C2D61_RS11240	COG2814	Major facilitator Superfamily
C2D61_RS11260	COG3038	cytochrome b561
C2D61_RS11280	COG0583	DNA-binding transcription factor activity
C2D61_RS11285	COG3485	protocatechuate 3,4-dioxygenase
C2D61_RS11290	COG3485	protocatechuate 3,4-dioxygenase
C2D61_RS11295	COG5383	Protein conserved in bacteria
C2D61_RS11300	COG2272	Belongs to the type-B carboxylesterase lipase family
C2D61_RS11315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D61_RS11320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D61_RS11325	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2D61_RS11330	COG0500	methyltransferase
C2D61_RS11345	COG3708	Transcriptional regulator
C2D61_RS11345	COG2207	Transcriptional regulator
C2D61_RS11350	COG3135	benzoate transporter
C2D61_RS11355	COG1396	sequence-specific DNA binding
C2D61_RS11365	COG0826	peptidase U32
C2D61_RS11385	COG1294	oxidase, subunit
C2D61_RS11390	COG1271	oxidase subunit
C2D61_RS11395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D61_RS11400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2D61_RS11405	COG3842	ATPase activity
C2D61_RS11410	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2D61_RS11415	COG1177	transmembrane transport
C2D61_RS11420	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS11455	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS11460	COG0747	negative chemotaxis
C2D61_RS11470	COG3238	Protein conserved in bacteria
C2D61_RS11475	COG1247	-acetyltransferase
C2D61_RS11485	COG2130	NADP-dependent
C2D61_RS11495	COG3691	Protein conserved in bacteria
C2D61_RS11500	COG1228	amidohydrolase
C2D61_RS11505	COG4772	TonB-dependent receptor
C2D61_RS11530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2D61_RS11535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D61_RS11540	COG1473	amidohydrolase
C2D61_RS11545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D61_RS11550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS11560	COG0765	amino acid transport
C2D61_RS11565	COG1126	abc transporter atp-binding protein
C2D61_RS11575	COG0625	glutathione transferase activity
C2D61_RS11595	COG2211	Major facilitator Superfamily
C2D61_RS11610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D61_RS11615	COG3842	ATPase activity
C2D61_RS11620	COG1840	ABC-type Fe3 transport system, periplasmic component
C2D61_RS11625	COG1178	ABC-type Fe3 transport system permease component
C2D61_RS11630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2D61_RS11635	COG2181	nitrate reductase activity
C2D61_RS11640	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2D61_RS11645	COG1140	nitrate reductase beta subunit
C2D61_RS11650	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2D61_RS11670	COG1414	Transcriptional regulator
C2D61_RS11675	COG4948	Mandelate Racemase Muconate Lactonizing
C2D61_RS11680	COG4829	muconolactone delta-isomerase
C2D61_RS11685	COG3485	protocatechuate 3,4-dioxygenase
C2D61_RS11720	COG0437	4 iron, 4 sulfur cluster binding
C2D61_RS11725	COG2864	formate dehydrogenase
C2D61_RS11740	COG2326	polyphosphate kinase activity
C2D61_RS11750	COG2814	Major facilitator Superfamily
C2D61_RS11760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D61_RS11770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D61_RS11780	COG0747	negative chemotaxis
C2D61_RS11785	COG1064	alcohol dehydrogenase
C2D61_RS11800	COG0488	(ABC) transporter
C2D61_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS11845	COG3729	General stress protein
C2D61_RS11855	COG3685	Protein conserved in bacteria
C2D61_RS11865	COG0366	Alpha amylase catalytic
C2D61_RS11875	COG2323	membrane
C2D61_RS11885	COG3111	PFAM Bacterial OB fold (BOF) protein
C2D61_RS11890	COG1764	response to oxidative stress
C2D61_RS11910	COG3781	membrane
C2D61_RS11915	COG0243	molybdopterin cofactor binding
C2D61_RS11920	COG0583	DNA-binding transcription factor activity
C2D61_RS11925	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D61_RS11930	COG2814	Major facilitator Superfamily
C2D61_RS11935	COG1285	pathogenesis
C2D61_RS11940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2D61_RS11950	COG0583	DNA-binding transcription factor activity
C2D61_RS11970	COG0519	Catalyzes the synthesis of GMP from XMP
C2D61_RS11970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2D61_RS12010	COG0596	Alpha beta hydrolase
C2D61_RS12020	COG2205	protein histidine kinase activity
C2D61_RS12035	COG0076	glutamate decarboxylase activity
C2D61_RS12040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D61_RS12045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D61_RS12050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D61_RS12055	COG1116	anion transmembrane transporter activity
C2D61_RS12060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2D61_RS12070	COG0673	inositol 2-dehydrogenase activity
C2D61_RS12085	COG3706	GGDEF domain
C2D61_RS12090	COG0402	S-adenosylhomocysteine deaminase activity
C2D61_RS12095	COG1953	Uracil, thiamine, allantoin
C2D61_RS12130	COG0406	alpha-ribazole phosphatase activity
C2D61_RS12140	COG1335	isochorismatase
C2D61_RS12160	COG2207	Transcriptional regulator
C2D61_RS12175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D61_RS12195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D61_RS12240	COG0765	amino acid transport
C2D61_RS12250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2D61_RS12260	COG2070	2-Nitropropane dioxygenase
C2D61_RS12265	COG0583	DNA-binding transcription factor activity
C2D61_RS12275	COG1902	pentaerythritol trinitrate reductase activity
C2D61_RS12280	COG4529	Protein conserved in bacteria
C2D61_RS12285	COG0477	Major facilitator Superfamily
C2D61_RS12330	COG2223	nitrite transmembrane transporter activity
C2D61_RS12340	COG1609	Transcriptional regulator
C2D61_RS12345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS12355	COG3037	sugar-specific permease SgaT UlaA
C2D61_RS12360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D61_RS12370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D61_RS12375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D61_RS12375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D61_RS12375	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2D61_RS12385	COG1652	LysM domain
C2D61_RS12410	COG0456	acetyltransferase
C2D61_RS12410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2D61_RS12420	COG0667	Aldo Keto reductase
C2D61_RS12425	COG0667	Aldo Keto reductase
C2D61_RS12430	COG3386	PFAM SMP-30 Gluconolaconase
C2D61_RS12435	COG0667	Aldo Keto reductase
C2D61_RS12455	COG4977	sequence-specific DNA binding
C2D61_RS12475	COG4977	sequence-specific DNA binding
C2D61_RS12480	COG1349	DNA-binding transcription factor activity
C2D61_RS12495	COG1349	DNA-binding transcription factor activity
C2D61_RS12500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D61_RS12505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D61_RS12510	COG0738	Major facilitator superfamily
C2D61_RS12555	COG1929	Belongs to the glycerate kinase type-1 family
C2D61_RS12560	COG3835	regulator
C2D61_RS12580	COG2186	Transcriptional regulator
C2D61_RS12585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS12585	COG1263	PTS System
C2D61_RS12595	COG2814	Major facilitator Superfamily
C2D61_RS12600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS12600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS12610	COG2819	hydrolase of the alpha beta superfamily
C2D61_RS12615	COG3300	MHYT domain
C2D61_RS12615	COG5001	Diguanylate cyclase
C2D61_RS12650	COG3188	usher protein
C2D61_RS12660	COG1649	PFAM Uncharacterised BCR, COG1649
C2D61_RS12665	COG3550	peptidyl-serine autophosphorylation
C2D61_RS12670	COG1396	sequence-specific DNA binding
C2D61_RS12675	COG2351	hydroxyisourate hydrolase activity
C2D61_RS12680	COG3195	allantoin biosynthetic process
C2D61_RS12680	COG3648	Uricase
C2D61_RS12685	COG2233	PERMEase
C2D61_RS12715	COG2207	Transcriptional regulator
C2D61_RS12730	COG4628	conserved protein (DUF2132)
C2D61_RS12750	COG2011	ABC-type metal ion transport system permease component
C2D61_RS12755	COG2070	2-Nitropropane dioxygenase
C2D61_RS12765	COG0477	Major facilitator Superfamily
C2D61_RS12835	COG2199	diguanylate cyclase activity
C2D61_RS12850	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS12855	COG0583	DNA-binding transcription factor activity
C2D61_RS12865	COG0039	L-malate dehydrogenase activity
C2D61_RS12870	COG1349	DNA-binding transcription factor activity
C2D61_RS12875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2D61_RS12880	COG3395	kinase activity
C2D61_RS12890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2D61_RS12895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D61_RS12900	COG2271	Major facilitator Superfamily
C2D61_RS12925	COG4977	sequence-specific DNA binding
C2D61_RS12940	COG2814	Major facilitator Superfamily
C2D61_RS12955	COG1129	ABC transporter
C2D61_RS12975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2D61_RS13015	COG2223	nitrite transmembrane transporter activity
C2D61_RS13020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2D61_RS13035	COG1349	DNA-binding transcription factor activity
C2D61_RS13040	COG2084	Dehydrogenase
C2D61_RS13045	COG3395	kinase activity
C2D61_RS13050	COG0235	Class ii aldolase
C2D61_RS13055	COG3622	Belongs to the hyi family
C2D61_RS13060	COG2610	gluconate transmembrane transporter activity
C2D61_RS13065	COG3708	Transcriptional regulator
C2D61_RS13065	COG2207	Transcriptional regulator
C2D61_RS13080	COG2200	EAL domain
C2D61_RS13085	COG1546	Belongs to the CinA family
C2D61_RS13090	COG0071	Belongs to the small heat shock protein (HSP20) family
C2D61_RS13100	COG2197	response regulator
C2D61_RS13110	COG2135	peptidase activity
C2D61_RS13115	COG2207	Transcriptional regulator
C2D61_RS13130	COG4221	oxidoreductase activity
C2D61_RS13135	COG1802	Transcriptional regulator
C2D61_RS13140	COG0589	response to stress
C2D61_RS13145	COG0246	Mannitol dehydrogenase
C2D61_RS13150	COG2271	Major facilitator Superfamily
C2D61_RS13165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D61_RS13180	COG0243	molybdopterin cofactor binding
C2D61_RS13185	COG0437	4 iron, 4 sulfur cluster binding
C2D61_RS13190	COG3302	dmso reductase anchor subunit
C2D61_RS13205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2D61_RS13210	COG1940	carbohydrate kinase activity
C2D61_RS13215	COG0583	DNA-binding transcription factor activity
C2D61_RS13220	COG2814	Major facilitator Superfamily
C2D61_RS13225	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2D61_RS13235	COG3591	Belongs to the peptidase S1B family
C2D61_RS13255	COG0628	permease
C2D61_RS13285	COG0679	Auxin Efflux Carrier
C2D61_RS13295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2D61_RS13330	COG3290	protein histidine kinase activity
C2D61_RS13335	COG4565	transcriptional regulatory protein
C2D61_RS13355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D61_RS13355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D61_RS13365	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D61_RS13370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2D61_RS13380	COG0183	Belongs to the thiolase family
C2D61_RS13385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2D61_RS13395	COG1414	Transcriptional regulator
C2D61_RS13400	COG2840	Smr protein MutS2
C2D61_RS13405	COG0583	DNA-binding transcription factor activity
C2D61_RS13415	COG1473	amidohydrolase
C2D61_RS13420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2D61_RS13435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2D61_RS13450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2D61_RS13455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2D61_RS13465	COG0531	amino acid
C2D61_RS13475	COG3136	membrane protein required for alginate biosynthesis
C2D61_RS13480	COG0745	RESPONSE REGULATOR receiver
C2D61_RS13490	COG2205	protein histidine kinase activity
C2D61_RS13500	COG0114	fumarate hydratase activity
C2D61_RS13505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D61_RS13505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D61_RS13510	COG1482	cell wall glycoprotein biosynthetic process
C2D61_RS13515	COG5339	Protein conserved in bacteria
C2D61_RS13520	COG1609	Transcriptional regulator
C2D61_RS13525	COG1263	PTS System
C2D61_RS13525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS13530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2D61_RS13555	COG2391	methyltransferase activity
C2D61_RS13560	COG0425	Belongs to the sulfur carrier protein TusA family
C2D61_RS13565	COG5562	phage envelope protein
C2D61_RS13570	COG0401	homolog of Blt101
C2D61_RS13575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2D61_RS13580	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS13585	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2D61_RS13590	COG0477	Major facilitator Superfamily
C2D61_RS13595	COG1113	amino acid transport
C2D61_RS13600	COG2988	succinylglutamate desuccinylase activity
C2D61_RS13605	COG3724	N-succinylarginine dihydrolase activity
C2D61_RS13610	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS13615	COG3138	arginine N-succinyltransferase
C2D61_RS13620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2D61_RS13625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2D61_RS13630	COG0667	Aldo Keto reductase
C2D61_RS13635	COG0583	DNA-binding transcription factor activity
C2D61_RS13660	COG4122	O-methyltransferase activity
C2D61_RS13665	COG1643	Atp-dependent helicase
C2D61_RS13680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D61_RS13685	COG3327	negative regulation of DNA-templated transcription, initiation
C2D61_RS13690	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2D61_RS13695	COG0183	Belongs to the thiolase family
C2D61_RS13700	COG2050	protein possibly involved in aromatic compounds catabolism
C2D61_RS13705	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2D61_RS13710	COG1024	Enoyl-CoA hydratase
C2D61_RS13715	COG1024	Enoyl-CoA hydratase
C2D61_RS13720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D61_RS13725	COG2151	metal-sulfur cluster biosynthetic enzyme
C2D61_RS13730	COG3396	Phenylacetate-CoA oxygenase
C2D61_RS13735	COG3460	Phenylacetate-CoA oxygenase
C2D61_RS13740	COG3396	Phenylacetate-CoA oxygenase
C2D61_RS13745	COG2030	dehydratase
C2D61_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS13765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2D61_RS13780	COG2072	flavoprotein involved in K transport
C2D61_RS13785	COG0583	DNA-binding transcription factor activity
C2D61_RS13790	COG1126	abc transporter atp-binding protein
C2D61_RS13800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS13815	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS13820	COG2207	Transcriptional regulator
C2D61_RS13825	COG3784	Protein of unknown function (DUF1318)
C2D61_RS13835	COG2911	Protein conserved in bacteria
C2D61_RS13840	COG0586	Pfam SNARE associated Golgi protein
C2D61_RS13845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2D61_RS13850	COG3187	Heat shock protein
C2D61_RS13855	COG3042	response to heat
C2D61_RS13860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2D61_RS13860	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2D61_RS13860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D61_RS13860	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2D61_RS13865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D61_RS13875	COG0589	response to stress
C2D61_RS13885	COG0513	Belongs to the DEAD box helicase family
C2D61_RS13895	COG1349	DNA-binding transcription factor activity
C2D61_RS13900	COG0673	inositol 2-dehydrogenase activity
C2D61_RS13915	COG1113	amino acid transport
C2D61_RS13920	COG1522	sequence-specific DNA binding
C2D61_RS13930	COG1448	Aminotransferase
C2D61_RS13935	COG2011	ABC-type metal ion transport system permease component
C2D61_RS13950	COG0436	Aminotransferase
C2D61_RS13955	COG0604	alcohol dehydrogenase
C2D61_RS13980	COG0583	DNA-binding transcription factor activity
C2D61_RS14000	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS14005	COG1309	transcriptional regulator
C2D61_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS14095	COG2885	chlorophyll binding
C2D61_RS14120	COG0693	protein deglycase activity
C2D61_RS14125	COG1078	dGTPase activity
C2D61_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS14135	COG0583	DNA-binding transcription factor activity
C2D61_RS14155	COG0656	L-ascorbic acid biosynthetic process
C2D61_RS14185	COG4166	transmembrane transport
C2D61_RS14190	COG2866	Carboxypeptidase
C2D61_RS14195	COG4948	Mandelate Racemase Muconate Lactonizing
C2D61_RS14200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2D61_RS14205	COG3180	Ammonia monooxygenase
C2D61_RS14215	COG1486	melibiose metabolic process
C2D61_RS14220	COG0583	DNA-binding transcription factor activity
C2D61_RS14230	COG3106	COG3106 Predicted ATPase
C2D61_RS14240	COG1983	PspC domain protein
C2D61_RS14250	COG1842	Phage shock protein A
C2D61_RS14255	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D61_RS14265	COG1473	amidohydrolase
C2D61_RS14280	COG0702	epimerase
C2D61_RS14295	COG2135	peptidase activity
C2D61_RS14305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2D61_RS14310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2D61_RS14315	COG3344	reverse transcriptase
C2D61_RS14320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2D61_RS14360	COG1196	nuclear chromosome segregation
C2D61_RS14360	COG1196	nuclear chromosome segregation
C2D61_RS14490	COG0484	heat shock protein binding
C2D61_RS14495	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2D61_RS14555	COG1484	DNA-dependent DNA replication
C2D61_RS14620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D61_RS14640	COG4171	peptide transport system, permease
C2D61_RS14655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2D61_RS14665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2D61_RS14670	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D61_RS14670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D61_RS14685	COG1349	DNA-binding transcription factor activity
C2D61_RS14695	COG0023	Translation Initiation Factor
C2D61_RS14705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2D61_RS14710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2D61_RS14715	COG0671	phosphoesterase, PA-phosphatase related
C2D61_RS14725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2D61_RS14750	COG0616	signal peptide processing
C2D61_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS14765	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C2D61_RS14785	COG0653	protein targeting
C2D61_RS14795	COG0583	DNA-binding transcription factor activity
C2D61_RS14805	COG0009	L-threonylcarbamoyladenylate synthase
C2D61_RS14815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2D61_RS14820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2D61_RS14820	COG0512	Glutamine amidotransferase of anthranilate synthase
C2D61_RS14825	COG0135	phosphoribosylanthranilate isomerase activity
C2D61_RS14825	COG0134	indole-3-glycerol-phosphate synthase activity
C2D61_RS14860	COG4774	siderophore transport
C2D61_RS14870	COG3047	cAMP biosynthetic process
C2D61_RS14875	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2D61_RS14905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D61_RS14910	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS14915	COG1988	membrane-bound metal-dependent
C2D61_RS14920	COG1823	symporter activity
C2D61_RS14930	COG0753	catalase activity
C2D61_RS14940	COG1486	melibiose metabolic process
C2D61_RS14945	COG2169	Transcriptional regulator
C2D61_RS14945	COG1917	Cupin 2, conserved barrel domain protein
C2D61_RS14950	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D61_RS14955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS14960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS14965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D61_RS14975	COG0322	excinuclease ABC activity
C2D61_RS14980	COG3678	ATP-independent chaperone mediated protein folding
C2D61_RS14990	COG3724	N-succinylarginine dihydrolase activity
C2D61_RS15000	COG3138	arginine N-succinyltransferase
C2D61_RS15010	COG0708	Exodeoxyribonuclease III
C2D61_RS15015	COG0398	Pfam SNARE associated Golgi protein
C2D61_RS15020	COG0398	Pfam SNARE associated Golgi protein
C2D61_RS15025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D61_RS15030	COG4134	Bacterial extracellular solute-binding protein
C2D61_RS15035	COG4135	transport system, permease component
C2D61_RS15040	COG4136	ATPase activity
C2D61_RS15045	COG2897	thiosulfate sulfurtransferase activity
C2D61_RS15050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2D61_RS15055	COG0494	nUDIX hydrolase
C2D61_RS15060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2D61_RS15065	COG3321	synthase
C2D61_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS15065	COG0604	alcohol dehydrogenase
C2D61_RS15070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2D61_RS15075	COG0709	Synthesizes selenophosphate from selenide and ATP
C2D61_RS15085	COG0778	Nitroreductase
C2D61_RS15090	COG0616	signal peptide processing
C2D61_RS15095	COG0252	asparaginase activity
C2D61_RS15100	COG1335	isochorismatase
C2D61_RS15115	COG3139	Protein of unknown function (DUF1315)
C2D61_RS15135	COG0656	L-ascorbic acid biosynthetic process
C2D61_RS15140	COG3713	MltA-interacting MipA family protein
C2D61_RS15145	COG2766	serine protein kinase
C2D61_RS15160	COG0386	Belongs to the glutathione peroxidase family
C2D61_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS15185	COG0583	DNA-binding transcription factor activity
C2D61_RS15190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2D61_RS15195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2D61_RS15200	COG3344	reverse transcriptase
C2D61_RS15210	COG0859	PFAM glycosyl transferase family 9
C2D61_RS15215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D61_RS15225	COG2207	Transcriptional regulator
C2D61_RS15230	COG2807	transmembrane transport
C2D61_RS15235	COG0504	CTP synthase activity
C2D61_RS15240	COG1683	Conserved Protein
C2D61_RS15245	COG3189	MarR family transcriptional regulator
C2D61_RS15250	COG3042	response to heat
C2D61_RS15255	COG2203	Gaf domain
C2D61_RS15255	COG2199	diguanylate cyclase activity
C2D61_RS15275	COG3182	Iron-regulated membrane protein
C2D61_RS15285	COG1560	Kdo2-lipid A biosynthetic process
C2D61_RS15295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2D61_RS15300	COG3706	GGDEF domain
C2D61_RS15305	COG0583	DNA-binding transcription factor activity
C2D61_RS15310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2D61_RS15335	COG1294	oxidase, subunit
C2D61_RS15340	COG1271	oxidase subunit
C2D61_RS15350	COG3685	Protein conserved in bacteria
C2D61_RS15355	COG3685	Protein conserved in bacteria
C2D61_RS15360	COG3729	General stress protein
C2D61_RS15370	COG1063	alcohol dehydrogenase
C2D61_RS15375	COG3813	Protein conserved in bacteria
C2D61_RS15390	COG0640	Transcriptional regulator
C2D61_RS15395	COG0538	isocitrate dehydrogenase activity
C2D61_RS15400	COG1187	pseudouridine synthase activity
C2D61_RS15420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2D61_RS15440	COG2205	protein histidine kinase activity
C2D61_RS15445	COG2850	peptidyl-arginine hydroxylation
C2D61_RS15465	COG1177	transmembrane transport
C2D61_RS15480	COG0318	PFAM AMP-dependent synthetase and ligase
C2D61_RS15485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D61_RS15490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D61_RS15495	COG0698	ribose 5-phosphate isomerase
C2D61_RS15510	COG3395	kinase activity
C2D61_RS15525	COG2390	Transcriptional regulator
C2D61_RS15535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2D61_RS15545	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2D61_RS15555	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2D61_RS15560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2D61_RS15565	COG1388	LysM domain
C2D61_RS15565	COG1376	ErfK ybiS ycfS ynhG family protein
C2D61_RS15575	COG1309	transcriptional regulator
C2D61_RS15585	COG3134	Outer membrane lipoprotein
C2D61_RS15590	COG1252	NADH dehydrogenase
C2D61_RS15615	COG5633	Lipoprotein
C2D61_RS15620	COG0537	adenosine 5'-monophosphoramidase activity
C2D61_RS15630	COG0084	hydrolase, TatD family'
C2D61_RS15635	COG0470	DNA polymerase III
C2D61_RS15645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2D61_RS15650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2D61_RS15655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D61_RS15670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2D61_RS15690	COG1399	metal-binding, possibly nucleic acid-binding protein
C2D61_RS15705	COG1530	ribonuclease E activity
C2D61_RS15710	COG0583	DNA-binding transcription factor activity
C2D61_RS15715	COG2814	Major facilitator Superfamily
C2D61_RS15735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D61_RS15780	COG1560	Kdo2-lipid A biosynthetic process
C2D61_RS15795	COG5645	(Lipo)protein
C2D61_RS15830	COG3381	protein complex oligomerization
C2D61_RS15860	COG1309	transcriptional regulator
C2D61_RS15865	COG0583	DNA-binding transcription factor activity
C2D61_RS15875	COG1335	isochorismatase
C2D61_RS15885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2D61_RS15890	COG1702	phosphate starvation-inducible protein PhoH
C2D61_RS15910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D61_RS15920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2D61_RS15935	COG1309	transcriptional regulator
C2D61_RS15970	COG2233	PERMEase
C2D61_RS15980	COG3729	General stress protein
C2D61_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS16020	COG0531	amino acid
C2D61_RS16025	COG0174	glutamine synthetase
C2D61_RS16030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2D61_RS16035	COG1396	sequence-specific DNA binding
C2D61_RS16035	COG1917	Cupin 2, conserved barrel domain protein
C2D61_RS16040	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS16045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2D61_RS16050	COG0583	DNA-binding transcription factor activity
C2D61_RS16055	COG0473	3-isopropylmalate dehydrogenase activity
C2D61_RS16060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2D61_RS16065	COG4638	Rieske (2fe-2S)
C2D61_RS16070	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS16075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D61_RS16105	COG0670	Belongs to the BI1 family
C2D61_RS16120	COG2207	Transcriptional regulator
C2D61_RS16125	COG1881	PFAM PEBP family protein
C2D61_RS16140	COG1832	CoA-binding protein
C2D61_RS16150	COG0210	DNA helicase
C2D61_RS16155	COG3304	Inner membrane component domain
C2D61_RS16160	COG1289	transmembrane transporter activity
C2D61_RS16165	COG3070	regulator of competence-specific genes
C2D61_RS16185	COG1067	ATP-dependent peptidase activity
C2D61_RS16195	COG3130	regulation of translation
C2D61_RS16200	COG3009	Protein conserved in bacteria
C2D61_RS16205	COG3008	intermembrane lipid transfer
C2D61_RS16205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2D61_RS16210	COG2995	paraquat-inducible protein a
C2D61_RS16215	COG0488	(ABC) transporter
C2D61_RS16225	COG0633	Ferredoxin
C2D61_RS16225	COG3217	Mosc domain protein beta barrel domain protein
C2D61_RS16240	COG0431	NADPH-dependent FMN reductase
C2D61_RS16245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D61_RS16250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D61_RS16255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D61_RS16265	COG0308	aminopeptidase N
C2D61_RS16275	COG1473	amidohydrolase
C2D61_RS16285	COG0814	amino acid
C2D61_RS16295	COG1522	sequence-specific DNA binding
C2D61_RS16305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D61_RS16310	COG1448	Aminotransferase
C2D61_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2D61_RS16320	COG3108	Peptidase M15
C2D61_RS16325	COG2989	Protein conserved in bacteria
C2D61_RS16335	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2D61_RS16345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2D61_RS16350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2D61_RS16355	COG3173	Aminoglycoside phosphotransferase
C2D61_RS16370	COG3214	Protein conserved in bacteria
C2D61_RS16385	COG2333	competence protein COMEC
C2D61_RS16385	COG0658	competence protein
C2D61_RS16395	COG0539	negative regulation of cytoplasmic translation
C2D61_RS16415	COG2323	membrane
C2D61_RS16420	COG1944	ATP diphosphatase activity
C2D61_RS16425	COG2116	formate transmembrane transporter activity
C2D61_RS16430	COG1882	Formate acetyltransferase
C2D61_RS16435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D61_RS16440	COG0477	Major facilitator Superfamily
C2D61_RS16450	COG3302	dmso reductase anchor subunit
C2D61_RS16455	COG0437	4 iron, 4 sulfur cluster binding
C2D61_RS16460	COG0243	molybdopterin cofactor binding
C2D61_RS16470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2D61_RS16480	COG1674	ftsk spoiiie
C2D61_RS16480	COG1178	ABC-type Fe3 transport system permease component
C2D61_RS16490	COG0492	ferredoxin-NADP+ reductase activity
C2D61_RS16495	COG4988	ABC transporter
C2D61_RS16500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2D61_RS16515	COG0542	response to heat
C2D61_RS16525	COG1278	Cold shock
C2D61_RS16535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS16540	COG3593	DNA synthesis involved in DNA repair
C2D61_RS16550	COG2431	L-lysine efflux transmembrane transporter activity
C2D61_RS16560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D61_RS16570	COG0028	Belongs to the TPP enzyme family
C2D61_RS16575	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2D61_RS16580	COG0702	epimerase
C2D61_RS16585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D61_RS16590	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2D61_RS16595	COG2203	Gaf domain
C2D61_RS16595	COG3706	GGDEF domain
C2D61_RS16595	COG5001	Diguanylate cyclase
C2D61_RS16595	COG4251	negative regulation of phosphorylation
C2D61_RS16605	COG1126	abc transporter atp-binding protein
C2D61_RS16610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS16615	COG4215	(ABC) transporter
C2D61_RS16620	COG4160	amino acid transport
C2D61_RS16625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS16630	COG5002	protein histidine kinase activity
C2D61_RS16635	COG0745	RESPONSE REGULATOR receiver
C2D61_RS16650	COG1177	transmembrane transport
C2D61_RS16655	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2D61_RS16660	COG3842	ATPase activity
C2D61_RS16665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2D61_RS16680	COG0778	Nitroreductase
C2D61_RS16705	COG3226	Transcriptional regulator
C2D61_RS16710	COG0738	Major facilitator superfamily
C2D61_RS16715	COG0561	phosphatase activity
C2D61_RS16720	COG2814	Major facilitator Superfamily
C2D61_RS16725	COG0671	phosphoesterase, PA-phosphatase related
C2D61_RS16730	COG1349	DNA-binding transcription factor activity
C2D61_RS16735	COG1686	Belongs to the peptidase S11 family
C2D61_RS16740	COG0625	glutathione transferase activity
C2D61_RS16745	COG2133	pyrroloquinoline quinone binding
C2D61_RS16755	COG2223	nitrite transmembrane transporter activity
C2D61_RS16775	COG0747	negative chemotaxis
C2D61_RS16790	COG0303	'Molybdopterin
C2D61_RS16795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2D61_RS16800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D61_RS16805	COG1882	Formate acetyltransferase
C2D61_RS16810	COG0561	phosphatase activity
C2D61_RS16820	COG1609	Transcriptional regulator
C2D61_RS16825	COG2271	Major facilitator Superfamily
C2D61_RS16835	COG0488	(ABC) transporter
C2D61_RS16840	COG2365	Tyrosine phosphatase family
C2D61_RS16845	COG1376	ErfK ybiS ycfS ynhG family protein
C2D61_RS16850	COG2188	Transcriptional regulator
C2D61_RS16855	COG2723	6-phospho-beta-galactosidase activity
C2D61_RS16860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2D61_RS16875	COG2194	sulfuric ester hydrolase activity
C2D61_RS16880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2D61_RS16895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS16900	COG0765	amino acid transport
C2D61_RS16905	COG1126	abc transporter atp-binding protein
C2D61_RS16910	COG0668	transmembrane transport
C2D61_RS16920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D61_RS16930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2D61_RS16940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2D61_RS16945	COG1199	ATP-dependent helicase activity
C2D61_RS16950	COG0513	Belongs to the DEAD box helicase family
C2D61_RS16955	COG3958	Transketolase
C2D61_RS16960	COG3959	Transketolase, thiamine diphosphate binding domain
C2D61_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS16970	COG2271	Major facilitator Superfamily
C2D61_RS16975	COG0583	DNA-binding transcription factor activity
C2D61_RS16980	COG1309	transcriptional regulator
C2D61_RS16985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS16990	COG1131	(ABC) transporter
C2D61_RS16995	COG0842	Transport permease protein
C2D61_RS17000	COG0842	Transport permease protein
C2D61_RS17010	COG3568	Endonuclease Exonuclease Phosphatase
C2D61_RS17015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2D61_RS17020	COG0392	lysyltransferase activity
C2D61_RS17025	COG0670	Belongs to the BI1 family
C2D61_RS17030	COG0314	molybdopterin synthase activity
C2D61_RS17035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2D61_RS17045	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2D61_RS17065	COG0745	RESPONSE REGULATOR receiver
C2D61_RS17070	COG0642	Histidine kinase
C2D61_RS17100	COG2226	methyltransferase
C2D61_RS17115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2D61_RS17120	COG1881	PFAM PEBP family protein
C2D61_RS17155	COG4677	pectinesterase activity
C2D61_RS17165	COG0589	response to stress
C2D61_RS17170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS17200	COG0789	Transcriptional regulator
C2D61_RS17205	COG2200	EAL domain
C2D61_RS17230	COG0561	phosphatase activity
C2D61_RS17240	COG4149	molybdate abc transporter
C2D61_RS17245	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2D61_RS17255	COG3585	molybdate ion transport
C2D61_RS17255	COG2005	Transcriptional regulator
C2D61_RS17260	COG1119	ATPase activity
C2D61_RS17270	COG1085	galactose-1-phosphate uridylyltransferase
C2D61_RS17280	COG2017	converts alpha-aldose to the beta-anomer
C2D61_RS17290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D61_RS17305	COG3201	nicotinamide mononucleotide transporter
C2D61_RS17310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2D61_RS17355	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2D61_RS17360	COG2885	chlorophyll binding
C2D61_RS17370	COG3064	Membrane
C2D61_RS17375	COG0848	biopolymer transport protein
C2D61_RS17380	COG0811	peptide transport
C2D61_RS17385	COG0824	Thioesterase
C2D61_RS17390	COG3790	cyd operon protein YbgE
C2D61_RS17395	COG4890	Cyd operon protein YbgT
C2D61_RS17400	COG1294	oxidase, subunit
C2D61_RS17405	COG1271	oxidase subunit
C2D61_RS17415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2D61_RS17425	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D61_RS17430	COG0567	Dehydrogenase, E1 component
C2D61_RS17435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2D61_RS17440	COG1053	succinate dehydrogenase
C2D61_RS17445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2D61_RS17450	COG2009	succinate dehydrogenase
C2D61_RS17485	COG1984	allophanate hydrolase subunit 2
C2D61_RS17490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2D61_RS17505	COG0415	Belongs to the DNA photolyase family
C2D61_RS17535	COG2205	protein histidine kinase activity
C2D61_RS17540	COG0745	RESPONSE REGULATOR receiver
C2D61_RS17550	COG0033	Phosphoglucomutase
C2D61_RS17560	COG0596	Alpha beta hydrolase
C2D61_RS17575	COG0735	belongs to the Fur family
C2D61_RS17615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2D61_RS17620	COG1940	carbohydrate kinase activity
C2D61_RS17620	COG1846	Transcriptional regulator
C2D61_RS17625	COG0647	UMP catabolic process
C2D61_RS17630	COG0367	asparagine synthase
C2D61_RS17670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D61_RS17680	COG1702	phosphate starvation-inducible protein PhoH
C2D61_RS17705	COG0765	amino acid transport
C2D61_RS17710	COG0765	amino acid transport
C2D61_RS17715	COG1126	abc transporter atp-binding protein
C2D61_RS17730	COG2888	peptidyl-tyrosine sulfation
C2D61_RS17745	COG1466	dna polymerase III delta subunit
C2D61_RS17760	COG0799	negative regulation of ribosome biogenesis
C2D61_RS17770	COG0768	penicillin binding
C2D61_RS17775	COG0772	Belongs to the SEDS family
C2D61_RS17780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2D61_RS17785	COG1686	Belongs to the peptidase S11 family
C2D61_RS17800	COG0583	DNA-binding transcription factor activity
C2D61_RS17815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2D61_RS17835	COG3069	C4-dicarboxylate transmembrane transporter activity
C2D61_RS17840	COG3719	Belongs to the RNase T2 family
C2D61_RS17845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2D61_RS17865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2D61_RS17870	COG0583	DNA-binding transcription factor activity
C2D61_RS17875	COG3969	phosphoadenosine phosphosulfate
C2D61_RS17880	COG1475	DNA binding
C2D61_RS17885	COG0436	Aminotransferase
C2D61_RS17910	COG1129	ABC transporter
C2D61_RS17915	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS17920	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS17930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D61_RS17945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2D61_RS17955	COG0402	S-adenosylhomocysteine deaminase activity
C2D61_RS17965	COG0483	inositol monophosphate 1-phosphatase activity
C2D61_RS17970	COG2271	Major facilitator Superfamily
C2D61_RS18000	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS18005	COG1129	ABC transporter
C2D61_RS18010	COG0371	Dehydrogenase
C2D61_RS18015	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS18030	COG2879	small protein
C2D61_RS18035	COG1966	Carbon starvation protein
C2D61_RS18045	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS18050	COG1535	isochorismatase
C2D61_RS18050	COG3433	isochorismatase activity
C2D61_RS18055	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2D61_RS18060	COG1169	isochorismate synthase
C2D61_RS18065	COG4592	Periplasmic binding protein
C2D61_RS18075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS18080	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS18085	COG1120	ATPase activity
C2D61_RS18090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2D61_RS18090	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2D61_RS18095	COG3251	PFAM MbtH domain protein
C2D61_RS18100	COG2382	esterase
C2D61_RS18105	COG4771	TonB-dependent receptor
C2D61_RS18115	COG1879	ABC-type sugar transport system periplasmic component
C2D61_RS18125	COG1129	ABC transporter
C2D61_RS18130	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS18135	COG5464	transposase or invertase
C2D61_RS18140	COG2390	Transcriptional regulator
C2D61_RS18145	COG3959	Transketolase, thiamine diphosphate binding domain
C2D61_RS18150	COG3958	Transketolase
C2D61_RS18160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2D61_RS18170	COG0583	DNA-binding transcription factor activity
C2D61_RS18175	COG0668	transmembrane transport
C2D61_RS18185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2D61_RS18210	COG0747	negative chemotaxis
C2D61_RS18215	COG0601	transmembrane transport
C2D61_RS18220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D61_RS18225	COG0444	Belongs to the ABC transporter superfamily
C2D61_RS18230	COG4608	Belongs to the ABC transporter superfamily
C2D61_RS18235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2D61_RS18240	COG4221	oxidoreductase activity
C2D61_RS18250	COG4215	(ABC) transporter
C2D61_RS18255	COG0765	amino acid transport
C2D61_RS18260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2D61_RS18275	COG0697	spore germination
C2D61_RS18290	COG4608	Belongs to the ABC transporter superfamily
C2D61_RS18295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D61_RS18305	COG4166	transmembrane transport
C2D61_RS18315	COG3698	Phosphodiester glycosidase
C2D61_RS18360	COG2315	Protein conserved in bacteria
C2D61_RS18365	COG0778	Nitroreductase
C2D61_RS18375	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS18385	COG3716	PTS system mannose fructose sorbose family IID component
C2D61_RS18390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2D61_RS18395	COG2222	sugar isomerase
C2D61_RS18400	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2D61_RS18400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D61_RS18415	COG0477	Major facilitator Superfamily
C2D61_RS18420	COG0668	transmembrane transport
C2D61_RS18425	COG1609	Transcriptional regulator
C2D61_RS18435	COG0673	inositol 2-dehydrogenase activity
C2D61_RS18445	COG2211	Major facilitator Superfamily
C2D61_RS18450	COG1113	amino acid transport
C2D61_RS18465	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS18470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2D61_RS18480	COG0531	amino acid
C2D61_RS18495	COG4680	protein conserved in bacteria
C2D61_RS18535	COG0667	Aldo Keto reductase
C2D61_RS18540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS18545	COG1473	amidohydrolase
C2D61_RS18565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS18570	COG1120	ATPase activity
C2D61_RS18575	COG1566	PFAM secretion protein HlyD family protein
C2D61_RS18620	COG4211	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS18625	COG1129	ABC transporter
C2D61_RS18640	COG0673	inositol 2-dehydrogenase activity
C2D61_RS18670	COG3104	oligopeptide transport
C2D61_RS18675	COG1982	Orn Lys Arg decarboxylase major
C2D61_RS18680	COG0531	amino acid
C2D61_RS18685	COG3710	Transcriptional regulator
C2D61_RS18695	COG1560	Kdo2-lipid A biosynthetic process
C2D61_RS18710	COG3188	usher protein
C2D61_RS18715	COG3121	Chaperone
C2D61_RS18720	COG3539	Fimbrial protein
C2D61_RS18765	COG2501	S4 domain
C2D61_RS18775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2D61_RS18790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2D61_RS18795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2D61_RS18810	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2D61_RS18815	COG4181	ATPase activity
C2D61_RS18820	COG2755	lipolytic protein G-D-S-L family
C2D61_RS18825	COG0300	oxidoreductase activity
C2D61_RS18830	COG3118	belongs to the thioredoxin family
C2D61_RS18835	COG0390	transport system, permease component
C2D61_RS18840	COG4619	ABC transporter
C2D61_RS18845	COG0330	HflC and HflK could
C2D61_RS18850	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2D61_RS18865	COG3735	TraB family
C2D61_RS18870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D61_RS18880	COG2223	nitrite transmembrane transporter activity
C2D61_RS18885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2D61_RS18885	COG4651	solute:proton antiporter activity
C2D61_RS18890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D61_RS18930	COG2832	Protein of unknown function (DUF454)
C2D61_RS18935	COG3923	Primosomal replication protein n
C2D61_RS18945	COG5464	transposase or invertase
C2D61_RS18950	COG1196	nuclear chromosome segregation
C2D61_RS18950	COG3264	Mechanosensitive ion channel
C2D61_RS18955	COG1309	transcriptional regulator
C2D61_RS18960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS18965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D61_RS18980	COG0110	maltose O-acetyltransferase activity
C2D61_RS19025	COG1874	Beta-galactosidase
C2D61_RS19030	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2D61_RS19035	COG3833	ABC-type maltose transport systems, permease component
C2D61_RS19040	COG1175	transmembrane transport
C2D61_RS19045	COG2182	Extracellular solute-binding protein
C2D61_RS19055	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2D61_RS19070	COG2364	Membrane
C2D61_RS19100	COG3695	enzyme binding
C2D61_RS19105	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2D61_RS19110	COG1946	Acyl-CoA thioesterase
C2D61_RS19115	COG0004	ammonium transporteR
C2D61_RS19120	COG0347	Belongs to the P(II) protein family
C2D61_RS19125	COG1132	(ABC) transporter
C2D61_RS19130	COG1132	(ABC) transporter
C2D61_RS19135	COG1522	sequence-specific DNA binding
C2D61_RS19150	COG4533	DNA binding
C2D61_RS19160	COG0824	Thioesterase
C2D61_RS19165	COG1555	photosystem II stabilization
C2D61_RS19170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D61_RS19175	COG0776	regulation of translation
C2D61_RS19180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2D61_RS19205	COG0271	Belongs to the BolA IbaG family
C2D61_RS19210	COG3056	Lipoprotein
C2D61_RS19215	COG2223	nitrite transmembrane transporter activity
C2D61_RS19220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2D61_RS19225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2D61_RS19230	COG1845	cytochrome c oxidase, subunit III
C2D61_RS19235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2D61_RS19250	COG1414	Transcriptional regulator
C2D61_RS19255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2D61_RS19260	COG1053	succinate dehydrogenase
C2D61_RS19270	COG1053	succinate dehydrogenase
C2D61_RS19285	COG0673	inositol 2-dehydrogenase activity
C2D61_RS19290	COG2814	Major facilitator Superfamily
C2D61_RS19300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2D61_RS19305	COG0693	protein deglycase activity
C2D61_RS19325	COG0142	geranyltranstransferase activity
C2D61_RS19335	COG0667	Aldo Keto reductase
C2D61_RS19340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2D61_RS19360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2D61_RS19360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2D61_RS19370	COG4238	major outer membrane lipoprotein
C2D61_RS19390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2D61_RS19395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2D61_RS19400	COG1862	Preprotein translocase
C2D61_RS19420	COG0450	alkyl hydroperoxide reductase
C2D61_RS19425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS19440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D61_RS19450	COG1228	amidohydrolase
C2D61_RS19460	COG1335	isochorismatase
C2D61_RS19465	COG0583	DNA-binding transcription factor activity
C2D61_RS19470	COG0366	Alpha amylase catalytic
C2D61_RS19495	COG0420	3'-5' exonuclease activity
C2D61_RS19500	COG0419	ATPase involved in DNA repair
C2D61_RS19505	COG1940	carbohydrate kinase activity
C2D61_RS19520	COG4126	flavin adenine dinucleotide binding
C2D61_RS19530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2D61_RS19535	COG3416	Protein conserved in bacteria
C2D61_RS19545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2D61_RS19555	COG1785	Belongs to the alkaline phosphatase family
C2D61_RS19595	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2D61_RS19600	COG1335	isochorismatase
C2D61_RS19605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2D61_RS19610	COG0113	porphobilinogen synthase activity
C2D61_RS19615	COG1943	Transposase
C2D61_RS19625	COG2175	clavaminate synthase activity
C2D61_RS19630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D61_RS19635	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2D61_RS19640	COG4521	taurine ABC transporter
C2D61_RS19645	COG2040	homocysteine
C2D61_RS19650	COG0833	amino acid
C2D61_RS19660	COG4303	Ethanolamine ammonia lyase large subunit
C2D61_RS19665	COG4302	ethanolamine ammonia-lyase activity
C2D61_RS19700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS19705	COG1126	abc transporter atp-binding protein
C2D61_RS19710	COG4597	amino acid ABC transporter
C2D61_RS19715	COG0765	amino acid transport
C2D61_RS19730	COG3188	usher protein
C2D61_RS19755	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2D61_RS19765	COG3639	organic phosphonate transmembrane transporter activity
C2D61_RS19790	COG0791	NLP P60 protein
C2D61_RS19895	COG0582	viral genome integration into host DNA
C2D61_RS19935	COG3121	Chaperone
C2D61_RS19940	COG3188	usher protein
C2D61_RS19970	COG2909	trisaccharide binding
C2D61_RS19975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2D61_RS19980	COG0022	dehydrogenase e1 component
C2D61_RS19985	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D61_RS19990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D61_RS20010	COG1070	Carbohydrate kinase
C2D61_RS20015	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS20020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D61_RS20025	COG3775	system Galactitol-specific IIC component
C2D61_RS20030	COG0625	glutathione transferase activity
C2D61_RS20035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2D61_RS20050	COG0579	oxidoreductase
C2D61_RS20055	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS20060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D61_RS20065	COG1113	amino acid transport
C2D61_RS20070	COG1802	Transcriptional regulator
C2D61_RS20090	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2D61_RS20095	COG0454	-acetyltransferase
C2D61_RS20110	COG2991	Protein conserved in bacteria
C2D61_RS20125	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2D61_RS20130	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2D61_RS20145	COG3034	peptidoglycan biosynthetic process
C2D61_RS20150	COG0121	glutamine amidotransferase
C2D61_RS20160	COG1960	acyl-CoA dehydrogenase activity
C2D61_RS20165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2D61_RS20175	COG0583	DNA-binding transcription factor activity
C2D61_RS20185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D61_RS20195	COG2226	methyltransferase
C2D61_RS20205	COG0741	lytic transglycosylase activity
C2D61_RS20205	COG1388	LysM domain
C2D61_RS20210	COG2226	methyltransferase
C2D61_RS20220	COG2814	Major facilitator Superfamily
C2D61_RS20225	COG0583	DNA-binding transcription factor activity
C2D61_RS20230	COG0656	L-ascorbic acid biosynthetic process
C2D61_RS20265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2D61_RS20275	COG2011	ABC-type metal ion transport system permease component
C2D61_RS20280	COG1464	Belongs to the NlpA lipoprotein family
C2D61_RS20290	COG1720	tRNA m6t6A37 methyltransferase activity
C2D61_RS20300	COG0791	NLP P60 protein
C2D61_RS20305	COG3015	lipoprotein NlpE involved in copper resistance
C2D61_RS20310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2D61_RS20325	COG4568	rho-dependent transcription termination
C2D61_RS20335	COG0346	lactoylglutathione lyase activity
C2D61_RS20340	COG1982	Orn Lys Arg decarboxylase major
C2D61_RS20350	COG0587	DNA-directed DNA polymerase activity
C2D61_RS20380	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2D61_RS20390	COG0750	zinc metalloprotease
C2D61_RS20395	COG0575	Belongs to the CDS family
C2D61_RS20405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2D61_RS20430	COG0024	Methionine aminopeptidase
C2D61_RS20435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2D61_RS20450	COG3835	regulator
C2D61_RS20455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D61_RS20475	COG2860	membrane
C2D61_RS20500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D61_RS20505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2D61_RS20510	COG1120	ATPase activity
C2D61_RS20515	COG4774	siderophore transport
C2D61_RS20520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2D61_RS20610	COG1643	Atp-dependent helicase
C2D61_RS20615	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2D61_RS20635	COG0617	tRNA 3'-terminal CCA addition
C2D61_RS20640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2D61_RS20660	COG0726	polysaccharide deacetylase
C2D61_RS20665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS20670	COG0842	Transport permease protein
C2D61_RS20675	COG1131	(ABC) transporter
C2D61_RS20680	COG0288	reversible hydration of carbon dioxide
C2D61_RS20690	COG4993	Dehydrogenase
C2D61_RS20695	COG2132	Multicopper oxidase
C2D61_RS20740	COG3064	Membrane
C2D61_RS20755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D61_RS20760	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D61_RS20765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2D61_RS20770	COG2186	Transcriptional regulator
C2D61_RS20775	COG1113	amino acid transport
C2D61_RS20780	COG2211	Major facilitator Superfamily
C2D61_RS20785	COG3940	Belongs to the glycosyl hydrolase 43 family
C2D61_RS20795	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2D61_RS20805	COG4969	Belongs to the N-Me-Phe pilin family
C2D61_RS20810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2D61_RS20815	COG1459	type II secretion system
C2D61_RS20840	COG0494	nUDIX hydrolase
C2D61_RS20860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2D61_RS20865	COG0849	cell division
C2D61_RS20890	COG0772	Belongs to the SEDS family
C2D61_RS20905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2D61_RS20910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2D61_RS20915	COG0768	penicillin binding
C2D61_RS20935	COG1609	Transcriptional regulator
C2D61_RS20945	COG0028	Belongs to the TPP enzyme family
C2D61_RS20990	COG0738	Major facilitator superfamily
C2D61_RS21000	COG0583	DNA-binding transcription factor activity
C2D61_RS21005	COG2271	Major facilitator Superfamily
C2D61_RS21010	COG2814	Major facilitator Superfamily
C2D61_RS21030	COG1178	ABC-type Fe3 transport system permease component
C2D61_RS21040	COG0586	Pfam SNARE associated Golgi protein
C2D61_RS21060	COG0235	Class ii aldolase
C2D61_RS21065	COG0417	DNA replication proofreading
C2D61_RS21075	COG0564	pseudouridine synthase activity
C2D61_RS21085	COG3493	citrate carrier protein
C2D61_RS21100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2D61_RS21105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2D61_RS21115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2D61_RS21160	COG0505	Belongs to the CarA family
C2D61_RS21225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2D61_RS21250	COG1047	Peptidyl-prolyl cis-trans
C2D61_RS21265	COG0196	riboflavin kinase activity
C2D61_RS21280	COG0583	DNA-binding transcription factor activity
C2D61_RS21305	COG4735	regulation of single-species biofilm formation
C2D61_RS21310	COG1584	GPR1 FUN34 yaaH family protein
C2D61_RS21315	COG0477	Major facilitator Superfamily
C2D61_RS21320	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2D61_RS21325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D61_RS21330	COG1115	amino acid carrier protein
C2D61_RS21345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2D61_RS21355	COG0460	homoserine dehydrogenase
C2D61_RS21355	COG0527	aspartate kinase activity
C2D61_RS21365	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2D61_RS21375	COG0745	RESPONSE REGULATOR receiver
C2D61_RS21380	COG4452	Inner membrane protein CreD
C2D61_RS21385	COG2205	protein histidine kinase activity
C2D61_RS21390	COG0745	RESPONSE REGULATOR receiver
C2D61_RS21395	COG3045	CreA protein
C2D61_RS21400	COG3708	Transcriptional regulator
C2D61_RS21400	COG2207	Transcriptional regulator
C2D61_RS21420	COG0741	lytic transglycosylase activity
C2D61_RS21425	COG0488	(ABC) transporter
C2D61_RS21435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2D61_RS21440	COG0560	Phosphoserine phosphatase
C2D61_RS21445	COG3726	membrane protein affecting hemolysin expression
C2D61_RS21475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D61_RS21480	COG0084	hydrolase, TatD family'
C2D61_RS21485	COG4667	esterase of the alpha-beta hydrolase superfamily
C2D61_RS21495	COG2823	Periplasmic or secreted lipoprotein
C2D61_RS21505	COG1011	Hydrolase
C2D61_RS21510	COG0456	acetyltransferase
C2D61_RS21515	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2D61_RS21545	COG3706	GGDEF domain
C2D61_RS21550	COG4114	ferric iron reductase
C2D61_RS21555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS21555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS21560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D61_RS21565	COG2197	response regulator
C2D61_RS21570	COG2197	response regulator
C2D61_RS21585	COG2966	Psort location CytoplasmicMembrane, score
C2D61_RS21600	COG1484	DNA-dependent DNA replication
C2D61_RS21615	COG5464	transposase or invertase
C2D61_RS21625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2D61_RS21630	COG3716	PTS system mannose fructose sorbose family IID component
C2D61_RS21635	COG3715	PTS system
C2D61_RS21650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2D61_RS21650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D61_RS21655	COG1214	PFAM Peptidase M22, glycoprotease
C2D61_RS21655	COG0456	acetyltransferase
C2D61_RS21665	COG1737	Transcriptional regulator
C2D61_RS21670	COG0800	Aldolase
C2D61_RS21675	COG3734	2-keto-3-deoxy-galactonokinase
C2D61_RS21690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2D61_RS21705	COG0531	amino acid
C2D61_RS21710	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS21715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2D61_RS21730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2D61_RS21730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2D61_RS21745	COG1846	Transcriptional regulator
C2D61_RS21750	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2D61_RS21760	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS21765	COG3384	dioxygenase
C2D61_RS21775	COG3971	2-oxopent-4-enoate hydratase activity
C2D61_RS21795	COG2368	4-hydroxyphenylacetate
C2D61_RS21800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D61_RS21815	COG1966	Carbon starvation protein
C2D61_RS21820	COG2879	small protein
C2D61_RS21825	COG0523	cobalamin synthesis protein
C2D61_RS21835	COG1012	belongs to the aldehyde dehydrogenase family
C2D61_RS21840	COG5464	transposase or invertase
C2D61_RS21845	COG2207	Transcriptional regulator
C2D61_RS21845	COG1917	Cupin 2, conserved barrel domain protein
C2D61_RS21855	COG2733	membrane
C2D61_RS21870	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2D61_RS21875	COG1924	4 iron, 4 sulfur cluster binding
C2D61_RS21890	COG1566	PFAM secretion protein HlyD family protein
C2D61_RS21900	COG5457	Domain of unknown function (DUF1127)
C2D61_RS21905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D61_RS21940	COG0583	DNA-binding transcription factor activity
C2D61_RS21945	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2D61_RS21955	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS21960	COG1129	ABC transporter
C2D61_RS21965	COG1879	ABC-type sugar transport system periplasmic component
C2D61_RS21975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS21980	COG1129	ABC transporter
C2D61_RS21980	COG0842	Transport permease protein
C2D61_RS21985	COG0842	Transport permease protein
C2D61_RS22015	COG2850	peptidyl-arginine hydroxylation
C2D61_RS22030	COG5002	protein histidine kinase activity
C2D61_RS22035	COG0745	RESPONSE REGULATOR receiver
C2D61_RS22040	COG1538	Outer membrane efflux protein
C2D61_RS22045	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS22050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D61_RS22055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D61_RS22065	COG3040	lipid binding
C2D61_RS22070	COG0789	Transcriptional regulator
C2D61_RS22080	COG0300	oxidoreductase activity
C2D61_RS22095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2D61_RS22115	COG3272	Protein of unknown function (DUF1722)
C2D61_RS22120	COG4580	involved in the transport of maltose and maltodextrins
C2D61_RS22125	COG2115	Belongs to the xylose isomerase family
C2D61_RS22130	COG2211	Major facilitator Superfamily
C2D61_RS22135	COG3507	Belongs to the glycosyl hydrolase 43 family
C2D61_RS22225	COG1715	Restriction endonuclease
C2D61_RS22230	COG1196	nuclear chromosome segregation
C2D61_RS22250	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C2D61_RS22255	COG0582	viral genome integration into host DNA
C2D61_RS22265	COG0288	reversible hydration of carbon dioxide
C2D61_RS22270	COG0659	secondary active sulfate transmembrane transporter activity
C2D61_RS22275	COG1064	alcohol dehydrogenase
C2D61_RS22280	COG1175	transmembrane transport
C2D61_RS22285	COG0395	ABC-type sugar transport system, permease component
C2D61_RS22290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2D61_RS22295	COG3842	ATPase activity
C2D61_RS22310	COG1082	Xylose isomerase domain protein TIM barrel
C2D61_RS22320	COG3962	Belongs to the TPP enzyme family
C2D61_RS22325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D61_RS22330	COG1737	Transcriptional regulator
C2D61_RS22330	COG0837	glucose binding
C2D61_RS22335	COG3718	enzyme involved in inositol metabolism
C2D61_RS22350	COG0433	COG0433 Predicted ATPase
C2D61_RS22355	COG0795	lipopolysaccharide-transporting ATPase activity
C2D61_RS22360	COG0795	lipopolysaccharide-transporting ATPase activity
C2D61_RS22370	COG2927	DNA polymerase III (CHI subunit)
C2D61_RS22375	COG0525	valine-tRNA ligase activity
C2D61_RS22400	COG2731	YhcH YjgK YiaL family protein
C2D61_RS22440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D61_RS22440	COG1263	PTS System
C2D61_RS22445	COG0366	Alpha amylase catalytic
C2D61_RS22450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D61_RS22455	COG1486	melibiose metabolic process
C2D61_RS22475	COG0602	queuosine metabolic process
C2D61_RS22480	COG2026	Addiction module toxin, RelE StbE family
C2D61_RS22485	COG3077	Addiction module antitoxin, RelB DinJ family
C2D61_RS22490	COG3711	transcriptional antiterminator
C2D61_RS22490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D61_RS22495	COG2706	6-phosphogluconolactonase activity
C2D61_RS22510	COG3964	amidohydrolase
C2D61_RS22545	COG0312	modulator of DNA gyrase
C2D61_RS22565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2D61_RS22575	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS22580	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS22585	COG1129	ABC transporter
C2D61_RS22590	COG1879	ABC-type sugar transport system periplasmic component
C2D61_RS22610	COG2105	PFAM AIG2 family protein
C2D61_RS22615	COG2911	Protein conserved in bacteria
C2D61_RS22620	COG0729	surface antigen
C2D61_RS22630	COG1253	flavin adenine dinucleotide binding
C2D61_RS22645	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2D61_RS22660	COG1733	regulation of RNA biosynthetic process
C2D61_RS22665	COG0702	epimerase
C2D61_RS22675	COG0697	spore germination
C2D61_RS22685	COG1113	amino acid transport
C2D61_RS22690	COG0545	Peptidyl-prolyl cis-trans isomerase
C2D61_RS22695	COG3061	Opacity-associated protein A
C2D61_RS22705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2D61_RS22710	COG2965	DNA replication, synthesis of RNA primer
C2D61_RS22770	COG1073	alpha beta
C2D61_RS22775	COG3650	response to hydrogen peroxide
C2D61_RS22785	COG1960	acyl-CoA dehydrogenase activity
C2D61_RS22790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D61_RS22795	COG0557	exoribonuclease II activity
C2D61_RS22810	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2D61_RS22820	COG0330	HflC and HflK could
C2D61_RS22825	COG0330	HflC and HflK could
C2D61_RS22830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2D61_RS22850	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D61_RS22855	COG0802	atpase or kinase
C2D61_RS22860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2D61_RS22860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2D61_RS22865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2D61_RS22885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D61_RS22905	COG1511	domain protein
C2D61_RS22905	COG3264	Mechanosensitive ion channel
C2D61_RS22920	COG1053	succinate dehydrogenase
C2D61_RS22925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2D61_RS22945	COG2076	Multidrug Resistance protein
C2D61_RS22950	COG5510	response to toxic substance
C2D61_RS22965	COG1509	lysine 2,3-aminomutase activity
C2D61_RS23030	COG0531	amino acid
C2D61_RS23035	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2D61_RS23040	COG1027	Aspartate ammonia-lyase
C2D61_RS23045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2D61_RS23060	COG1309	transcriptional regulator
C2D61_RS23110	COG0457	Tetratricopeptide repeat
C2D61_RS23115	COG1649	PFAM Uncharacterised BCR, COG1649
C2D61_RS23115	COG0726	polysaccharide deacetylase
C2D61_RS23120	COG1215	transferase activity, transferring glycosyl groups
C2D61_RS23135	COG0861	Integral membrane protein TerC family
C2D61_RS23170	COG1486	melibiose metabolic process
C2D61_RS23175	COG2169	Transcriptional regulator
C2D61_RS23185	COG2824	Alkylphosphonate utilization operon protein PhnA
C2D61_RS23190	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C2D61_RS23195	COG2188	Transcriptional regulator
C2D61_RS23200	COG3624	Phosphonate C-P lyase system protein PhnG
C2D61_RS23205	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2D61_RS23210	COG3626	phosphonate metabolism
C2D61_RS23215	COG3627	carbon phosphorus lyase activity
C2D61_RS23220	COG4107	phosphonate C-P lyase system protein PhnK
C2D61_RS23225	COG4778	phosphonate C-P lyase system protein PhnL
C2D61_RS23230	COG3454	Phosphonate metabolism
C2D61_RS23240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2D61_RS23250	COG4191	Histidine kinase
C2D61_RS23250	COG0784	Response regulator, receiver
C2D61_RS23255	COG1129	ABC transporter
C2D61_RS23260	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS23295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2D61_RS23300	COG1301	dicarboxylic acid transport
C2D61_RS23310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2D61_RS23315	COG3162	membrane
C2D61_RS23345	COG3539	Fimbrial protein
C2D61_RS23350	COG1346	cytolysis
C2D61_RS23355	COG1380	Effector of murein hydrolase LrgA
C2D61_RS23360	COG0583	DNA-binding transcription factor activity
C2D61_RS23365	COG0025	NhaP-type Na H and K H
C2D61_RS23370	COG2252	PERMEase
C2D61_RS23375	COG0625	glutathione transferase activity
C2D61_RS23380	COG0789	Transcriptional regulator
C2D61_RS23390	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2D61_RS23420	COG1234	tRNA 3'-trailer cleavage
C2D61_RS23425	COG1609	Transcriptional regulator
C2D61_RS23430	COG0483	inositol monophosphate 1-phosphatase activity
C2D61_RS23440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D61_RS23460	COG4771	TonB-dependent receptor
C2D61_RS23465	COG0741	lytic transglycosylase activity
C2D61_RS23480	COG2315	Protein conserved in bacteria
C2D61_RS23485	COG0432	Pfam Uncharacterised protein family UPF0047
C2D61_RS23500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2D61_RS23505	COG0305	Participates in initiation and elongation during chromosome replication
C2D61_RS23520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2D61_RS23530	COG0735	belongs to the Fur family
C2D61_RS23535	COG3237	CsbD-like
C2D61_RS23540	COG0534	Mate efflux family protein
C2D61_RS23550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2D61_RS23620	COG0251	oxidation-reduction process
C2D61_RS23630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2D61_RS23640	COG0527	aspartate kinase activity
C2D61_RS23695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2D61_RS23725	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2D61_RS23735	COG0456	acetyltransferase
C2D61_RS23765	COG0151	Belongs to the GarS family
C2D61_RS23775	COG4191	Histidine kinase
C2D61_RS23780	COG3678	ATP-independent chaperone mediated protein folding
C2D61_RS23815	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2D61_RS23830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2D61_RS23835	COG2104	thiamine diphosphate biosynthetic process
C2D61_RS23850	COG3706	GGDEF domain
C2D61_RS23860	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D61_RS23865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2D61_RS23900	COG0250	Participates in transcription elongation, termination and antitermination
C2D61_RS23975	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2D61_RS23985	COG1739	Uncharacterized protein family UPF0029
C2D61_RS24025	COG0805	protein transport
C2D61_RS24045	COG3165	ubiquinone biosynthetic process from chorismate
C2D61_RS24075	COG0583	DNA-binding transcription factor activity
C2D61_RS24080	COG0697	spore germination
C2D61_RS24085	COG0561	phosphatase activity
C2D61_RS24090	COG2267	carboxylic ester hydrolase activity
C2D61_RS24095	COG1280	lysine exporter protein (LysE YggA)
C2D61_RS24105	COG1280	lysine exporter protein (LysE YggA)
C2D61_RS24135	COG0210	DNA helicase
C2D61_RS24140	COG1011	Hydrolase
C2D61_RS24170	COG3072	Adenylate cyclase
C2D61_RS24185	COG2959	enzyme of heme biosynthesis
C2D61_RS24190	COG3071	HemY protein
C2D61_RS24235	COG2244	polysaccharide biosynthetic process
C2D61_RS24240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2D61_RS24245	COG0456	acetyltransferase
C2D61_RS24250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2D61_RS24255	COG1088	dTDP-glucose 4,6-dehydratase activity
C2D61_RS24260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2D61_RS24265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2D61_RS24275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2D61_RS24280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2D61_RS24285	COG3118	belongs to the thioredoxin family
C2D61_RS24310	COG1811	Na channel or pump
C2D61_RS24320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D61_RS24325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D61_RS24335	COG0583	DNA-binding transcription factor activity
C2D61_RS24340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2D61_RS24355	COG3978	acetolactate synthase activity
C2D61_RS24375	COG3085	chromosome segregation
C2D61_RS24450	COG0583	DNA-binding transcription factor activity
C2D61_RS24465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2D61_RS24480	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2D61_RS24485	COG2207	Transcriptional regulator
C2D61_RS24495	COG0371	Dehydrogenase
C2D61_RS24500	COG0697	spore germination
C2D61_RS24510	COG0583	DNA-binding transcription factor activity
C2D61_RS24520	COG0737	Belongs to the 5'-nucleotidase family
C2D61_RS24530	COG0460	homoserine dehydrogenase
C2D61_RS24530	COG0527	aspartate kinase activity
C2D61_RS24535	COG0626	cystathionine gamma-synthase activity
C2D61_RS24550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2D61_RS24555	COG1609	Transcriptional regulator
C2D61_RS24560	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2D61_RS24575	COG1575	Belongs to the MenA family. Type 1 subfamily
C2D61_RS24595	COG3678	ATP-independent chaperone mediated protein folding
C2D61_RS24600	COG0745	RESPONSE REGULATOR receiver
C2D61_RS24605	COG2205	protein histidine kinase activity
C2D61_RS24610	COG2258	MOSC domain
C2D61_RS24615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2D61_RS24655	COG1129	ABC transporter
C2D61_RS24660	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS24665	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS24670	COG1454	alcohol dehydrogenase
C2D61_RS24680	COG2211	Major facilitator Superfamily
C2D61_RS24740	COG0205	6-phosphofructokinase activity
C2D61_RS24760	COG0437	4 iron, 4 sulfur cluster binding
C2D61_RS24765	COG2864	formate dehydrogenase
C2D61_RS24780	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2D61_RS24790	COG0456	acetyltransferase
C2D61_RS24805	COG1011	Hydrolase
C2D61_RS24820	COG3852	Histidine kinase
C2D61_RS24835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2D61_RS24855	COG0204	Acyl-transferase
C2D61_RS24865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2D61_RS24870	COG3084	Protein conserved in bacteria
C2D61_RS24880	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2D61_RS24905	COG2186	Transcriptional regulator
C2D61_RS24910	COG0477	Major facilitator Superfamily
C2D61_RS24915	COG1609	Transcriptional regulator
C2D61_RS24920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D61_RS24930	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D61_RS24935	COG1129	ABC transporter
C2D61_RS24965	COG1522	sequence-specific DNA binding
C2D61_RS24970	COG0716	FMN binding
C2D61_RS24985	COG3312	ion transport
C2D61_RS25035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2D61_RS25040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2D61_RS25045	COG0573	inorganic phosphate transmembrane transporter activity
C2D61_RS25050	COG0581	inorganic phosphate transmembrane transporter activity
C2D61_RS25055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2D61_RS25060	COG0704	Plays a role in the regulation of phosphate uptake
C2D61_RS25070	COG2382	esterase
C2D61_RS25075	COG0363	glucosamine-6-phosphate deaminase activity
C2D61_RS25080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D61_RS25085	COG2252	PERMEase
C2D61_RS25090	COG0431	NADPH-dependent FMN reductase
C2D61_RS25095	COG2091	lysine biosynthetic process via aminoadipic acid
C2D61_RS25115	COG0454	-acetyltransferase
C2D61_RS25155	COG0717	Belongs to the dCTP deaminase family
C2D61_RS25170	COG0582	viral genome integration into host DNA
C2D61_RS25185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2D61_RS25315	COG1660	Displays ATPase and GTPase activities
C2D61_RS25380	COG1028	Short-chain dehydrogenase reductase Sdr
C2D61_RS25555	COG0789	Transcriptional regulator
C2D61_RS25580	COG3344	reverse transcriptase
C2D61_RS25800	COG0633	Ferredoxin
C2D61_RS26130	COG2084	Dehydrogenase
C2D61_RS26135	COG1349	DNA-binding transcription factor activity
C2D61_RS26150	COG3173	Aminoglycoside phosphotransferase
C2D61_RS26170	COG1695	Transcriptional regulator
C2D61_RS26210	COG1357	PFAM Pentapeptide repeats (8 copies)
C2D61_RS26305	COG3344	reverse transcriptase
C2D61_RS26485	COG3385	transposase activity
C2D61_RS26505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2D61_RS26550	COG0025	NhaP-type Na H and K H
C2D61_RS26570	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D61_RS26640	COG3039	Transposase
C2D61_RS26680	COG3039	Transposase
C2D61_RS26720	COG3039	Transposase
C2D61_RS26790	COG1358	cellular component organization or biogenesis
C2D61_RS26820	COG0789	Transcriptional regulator
C2D61_RS27125	COG0210	DNA helicase
C2D61_RS27350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2D61_RS27500	COG0484	heat shock protein binding
C2D61_RS27535	COG2894	cell division