locus-tag class description G9174_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G9174_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G9174_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9174_RS00025 ENOG410667J hydrolase G9174_RS00040 ENOG4105EMF GntR family transcriptional regulator G9174_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 G9174_RS00050 ENOG4108RTU Aldolase G9174_RS00055 ENOG4105CXK mandelate racemase muconate lactonizing G9174_RS00060 ENOG4105DJB Major Facilitator Superfamily G9174_RS00065 ENOG4105D99 atp gtp-binding protein G9174_RS00070 ENOG4105R2A (LipO)protein G9174_RS00085 ENOG4105F5P DNA-damage-inducible protein d G9174_RS00090 ENOG4105D0C transport protein G9174_RS00095 ENOG4105FDP GntR family transcriptional regulator G9174_RS00100 ENOG4105CI1 PTS System G9174_RS00105 ENOG4105F8D glycoside hydrolase family 4 G9174_RS00110 ENOG4105VG5 Membrane G9174_RS00115 ENOG4105JP4 Inner membrane protein yidG G9174_RS00140 ENOG4105W8I Transcriptional regulator G9174_RS00145 ENOG4105E5M Multidrug resistance protein D G9174_RS00175 ENOG4105C7K acetolactate synthase G9174_RS00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit G9174_RS00185 ENOG4108KX4 response regulator G9174_RS00190 ENOG4105BZU Histidine kinase G9174_RS00195 ENOG4105CXY transporter G9174_RS00200 ENOG4105CXY transporter G9174_RS00205 ENOG4108SAJ Protein of unknown function (DUF1198) G9174_RS00225 ENOG4108KAZ Involved in phosphonate degradation (By similarity) G9174_RS00230 ENOG4107STF Involved in phosphonate degradation (By similarity) G9174_RS00235 ENOG4106S9K Transcriptional regulator G9174_RS00250 ENOG4108MP3 ABC transporter, permease G9174_RS00260 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G9174_RS00265 ENOG4105VCP PTS System G9174_RS00270 ENOG4105CK1 PTS System G9174_RS00280 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS00285 ENOG4105D2S major facilitator superfamily G9174_RS00295 ENOG4107F9Y LysR family transcriptional regulator G9174_RS00305 ENOG4105JSC dimethylmenaquinone methyltransferase G9174_RS00320 ENOG4105T8A Uncharacterized protein YicS G9174_RS00325 ENOG4108UZ3 Transporter G9174_RS00330 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) G9174_RS00335 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G9174_RS00340 ENOG4105C2C drug resistance transporter, Bcr CflA G9174_RS00345 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G9174_RS00350 ENOG4105BZS acriflavin resistance protein G9174_RS00355 ENOG4105C1P efflux transporter, rnd family, mfp subunit G9174_RS00375 ENOG410630P Transcriptional regulator G9174_RS00385 ENOG4105CR8 Transcriptional regulator G9174_RS00410 ENOG4105D01 (LipO)protein G9174_RS00425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein G9174_RS00435 ENOG4105DQ4 alcohol dehydrogenase G9174_RS00455 ENOG4105NI3 Protein of unknown function (DUF3237) G9174_RS00465 ENOG4105CT4 transporter G9174_RS00470 ENOG4105CJQ hydrolase, family 31 G9174_RS00480 ENOG4105F8D glycoside hydrolase family 4 G9174_RS00485 ENOG4105CI1 PTS System G9174_RS00490 ENOG4105JV1 AsmA family G9174_RS00495 ENOG4105C2W permease G9174_RS00500 ENOG4105D6U Sodium Glutamate Symporter G9174_RS00505 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G9174_RS00510 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9174_RS00515 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) G9174_RS00520 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G9174_RS00535 ENOG4105CP7 Triose-phosphate isomerase G9174_RS00540 ENOG4105EBK exported protein G9174_RS00545 ENOG4108VTS Membrane G9174_RS00550 ENOG4105DP0 ferredoxin-NADP reductase G9174_RS00555 ENOG4105CBT Fructose-1,6-bisphosphatase G9174_RS00560 ENOG4105CB5 ATP-dependent DNA helicase recG G9174_RS00565 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase G9174_RS00570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G9174_RS00580 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G9174_RS00585 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) G9174_RS00590 ENOG4105EN6 Membrane G9174_RS00600 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G9174_RS00605 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) G9174_RS00610 ENOG4105DSJ YicC domain protein G9174_RS00630 ENOG4105CJ1 ABC, transporter G9174_RS00635 ENOG4107QWP ABC-2 type transporter G9174_RS00640 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G9174_RS00650 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) G9174_RS00655 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G9174_RS00660 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G9174_RS00665 ENOG4105W5Q DNA repair protein (RadC G9174_RS00670 ENOG4105KDC 50s ribosomal protein l28 G9174_RS00675 ENOG4105W0E 50S ribosomal protein L33 G9174_RS00680 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G9174_RS00685 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G9174_RS00690 ENOG4106WTF Glycosyl transferase, family 2 G9174_RS00695 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G9174_RS00700 ENOG4105K64 Glycosyl transferase, family 2 G9174_RS00705 ENOG4105CPK Glycosyl transferase (Group 1 G9174_RS00715 ENOG4105DKP glycosyl transferase, family 9 G9174_RS00740 ENOG4105D16 lipopolysaccharide heptosyltransferase i G9174_RS00745 ENOG4105XA0 heptosyltransferase ii G9174_RS00750 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) G9174_RS00755 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G9174_RS00760 ENOG4105CPQ Dehydrogenase G9174_RS00765 ENOG4106WTF Glycosyl transferase, family 2 G9174_RS00770 ENOG4105PXI polysaccharide deacetylase G9174_RS00775 ENOG41063SB peptidase G9174_RS00785 ENOG4107YZP Rhodanese domain protein G9174_RS00790 ENOG4105VW4 glutaredoxin 3 G9174_RS00795 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) G9174_RS00800 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G9174_RS00805 ENOG4105D7W serine acetyltransferase G9174_RS00810 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G9174_RS00815 ENOG4105DMF Dehydrogenase G9174_RS00820 ENOG41073TP transcriptional regulator G9174_RS00825 ENOG4105DAA L-lactate G9174_RS00830 ENOG4108YYI Protein of unknown function (DUF2810) G9174_RS00840 ENOG4105E61 Mannitol repressor protein G9174_RS00845 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase G9174_RS00850 ENOG4105CTS PTS system mannitol-specific G9174_RS00855 ENOG4105FP6 Protein of unknown function (DUF3302) G9174_RS00860 ENOG4105EFX secretion protein, HlyD family G9174_RS00865 ENOG4108U78 Glutathione S-transferase G9174_RS00870 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) G9174_RS00875 ENOG4105EM7 Selenocysteine-specific translation elongation factor G9174_RS00880 ENOG4105J4Q Transcriptional regulator G9174_RS00885 ENOG4108RC0 Electron transport protein G9174_RS00890 ENOG4105JKW Valine--pyruvate aminotransferase G9174_RS00895 ENOG4107T9C Alpha amylase catalytic region G9174_RS00900 ENOG4108UR8 BAX protein G9174_RS00905 ENOG4105T16 Transcriptional regulator (AraC family) G9174_RS00910 ENOG4108HWW ABC transporter G9174_RS00920 ENOG4105DFW ABC transporter G9174_RS00930 ENOG4105CMG Carbohydrate kinase G9174_RS00935 ENOG410688U Inner membrane protein yiaB G9174_RS00940 ENOG4108Z12 YiaAB two helix domain-containing protein G9174_RS00945 ENOG4105MEV Acyl-transferase G9174_RS00955 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit G9174_RS00960 ENOG4105C38 Glycyl-tRNA synthetase beta subunit G9174_RS00980 ENOG41060TC Hok gef cell toxic protein G9174_RS00995 ENOG4105MVF Transcriptional regulator G9174_RS01000 ENOG4105D2S major facilitator superfamily G9174_RS01005 ENOG4106JH6 (LipO)protein G9174_RS01010 ENOG4105C5I Dehydrogenase G9174_RS01020 ENOG4105D7K pfkb domain protein G9174_RS01030 ENOG4108M60 Transcriptional regulator G9174_RS01035 ENOG4108ZG0 Ompa motb domain protein G9174_RS01040 ENOG4107QY8 reductase G9174_RS01045 ENOG4105HNP -acetyltransferase G9174_RS01050 ENOG4108R3E Dna-3-methyladenine glycosylase i G9174_RS01055 ENOG4105EAX Putative lipase G9174_RS01060 ENOG4105FCD Major Facilitator G9174_RS01065 ENOG4105DIJ Phosphoethanolamine transferase G9174_RS01090 ENOG4105DEF Extracellular solute-binding protein, family 5 G9174_RS01095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G9174_RS01100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9174_RS01105 ENOG4105C3U ABC transporter G9174_RS01110 ENOG4108JQ7 (ABC) transporter G9174_RS01130 ENOG4107QZ7 Cellulose synthase catalytic subunit G9174_RS01135 ENOG4107EEX Cellulose synthase regulator protein G9174_RS01140 ENOG4105EJG cellulose synthase G9174_RS01155 ENOG4105D1V cellulose synthase operon protein YhjU G9174_RS01160 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT G9174_RS01165 ENOG4105U74 cellulose biosynthesis protein BcsE G9174_RS01170 ENOG410661M cytoplasmic protein G9174_RS01175 ENOG4105UTS cellulose synthase operon protein YhjQ G9174_RS01180 ENOG4107QZ7 Cellulose synthase catalytic subunit G9174_RS01185 ENOG4107EEX Cellulose synthase regulator protein G9174_RS01190 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) G9174_RS01195 ENOG4105EJG cellulose synthase G9174_RS01200 ENOG4105BZU Histidine kinase G9174_RS01205 ENOG4105CK2 sodium dicarboxylate symporter G9174_RS01210 ENOG4105CS0 peptidase G9174_RS01220 ENOG41066T0 asmA family G9174_RS01225 ENOG4105CSH Transporter G9174_RS01230 ENOG4107H3J ribonuclease G9174_RS01235 ENOG4105CBN LysR family transcriptional regulator G9174_RS01240 ENOG4105CHR reductase G9174_RS01255 ENOG4105C0A alcohol dehydrogenase G9174_RS01265 ENOG4105DC8 reductase G9174_RS01270 ENOG4105D6S protein involved in catabolism of external DNA G9174_RS01275 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G9174_RS01280 ENOG4105DGW oligopeptidase A G9174_RS01285 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) G9174_RS01290 ENOG4105DUX Transporter G9174_RS01300 ENOG4108V6B universal stress protein B G9174_RS01305 ENOG4105CJ3 phosphate transporter G9174_RS01310 ENOG4105CBX hi0933 family G9174_RS01315 ENOG4105CJW magnesium transporter G9174_RS01325 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) G9174_RS01335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9174_RS01340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G9174_RS01345 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G9174_RS01355 ENOG4105PY6 Phenolic acid decarboxylase G9174_RS01360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G9174_RS01365 ENOG4105CKK Glycosyl transferase, family 2 G9174_RS01370 ENOG4105C3I Nad-dependent epimerase dehydratase G9174_RS01375 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G9174_RS01380 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G9174_RS01385 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G9174_RS01390 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G9174_RS01395 ENOG4105DSF transport protein G9174_RS01400 ENOG4105F9N Major Facilitator Superfamily G9174_RS01405 ENOG4108W1V Lipoprotein G9174_RS01410 ENOG4105EX9 Membrane G9174_RS01415 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G9174_RS01425 ENOG4107FS9 Membrane G9174_RS01435 ENOG4105MG3 Membrane G9174_RS01440 ENOG4106H78 methyltransferase G9174_RS01445 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G9174_RS01450 ENOG4105CAK Cell division ATP-binding protein ftsE G9174_RS01455 ENOG4105CRP Part of the ABC transporter FtsEX involved in G9174_RS01470 ENOG4108JPW Aminotransferase G9174_RS01480 ENOG4105CP9 extracellular ligand-binding receptor G9174_RS01485 ENOG4105U59 -acetyltransferase G9174_RS01490 ENOG4105CP9 extracellular ligand-binding receptor G9174_RS01495 ENOG4105C32 Amino acid ABC transporter (Permease) G9174_RS01500 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G9174_RS01505 ENOG4105C0Z ABC transporter G9174_RS01510 ENOG4108IV0 ABC, transporter G9174_RS01515 ENOG41060M8 Pfam:PhdYeFM G9174_RS01525 ENOG4105BZ7 extracellular solute-binding protein family 1 G9174_RS01530 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G9174_RS01545 ENOG4107T6V glycerophosphoryl diester phosphodiesterase G9174_RS01550 ENOG4105WC8 Conserved Protein G9174_RS01555 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G9174_RS01560 ENOG4105WCN acetyltransferase G9174_RS01570 ENOG4105D9R oxidoreductase G9174_RS01575 ENOG4105C2I pirin domain protein G9174_RS01580 ENOG4105DIQ Transcriptional regulator G9174_RS01585 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G9174_RS01590 ENOG4105C6Z Gluconate G9174_RS01600 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G9174_RS01605 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G9174_RS01610 ENOG4108IUM Glycogen debranching enzyme G9174_RS01615 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G9174_RS01620 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) G9174_RS01625 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G9174_RS01640 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G9174_RS01645 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) G9174_RS01650 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) G9174_RS01655 ENOG4105E98 transcriptional regulator DeoR family G9174_RS01660 ENOG41061ZR Transcriptional regulator G9174_RS01665 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G9174_RS01670 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) G9174_RS01675 ENOG4105C6Z Gluconate G9174_RS01680 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) G9174_RS01685 ENOG4105MJ2 Competence protein G9174_RS01690 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G9174_RS01700 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) G9174_RS01705 ENOG4105CE1 Ferrous iron transport protein b G9174_RS01710 ENOG4105XFK Ferrous iron transport protein A G9174_RS01715 ENOG4105BZM domain protein G9174_RS01720 ENOG4108RRZ Transcription elongation factor GreB G9174_RS01730 ENOG4105E0F Histidine kinase G9174_RS01745 ENOG4105VEJ Heat shock protein G9174_RS01750 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 G9174_RS01755 ENOG4105DQY intracellular growth attenuator G9174_RS01760 ENOG4107RK2 ADP-ribose diphosphatase NudE G9174_RS01765 ENOG4108JQC penicillin-binding protein 1A G9174_RS01790 ENOG4105E4G Type IV pilus G9174_RS01795 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G9174_RS01800 ENOG4105D49 3-dehydroquinate synthase G9174_RS01805 ENOG4105EGB membrane protein DamX G9174_RS01810 ENOG4105DFE Dna adenine methylase G9174_RS01815 ENOG4105DJV ribulose-phosphate 3-epimerase G9174_RS01825 ENOG4105C31 Tryptophanyl-tRNA synthetase G9174_RS01830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G9174_RS01835 ENOG4105WZK nitrite reductase NADPH small subunit G9174_RS01840 ENOG4107QZF nitrite reductase NADPH large subunit G9174_RS01845 ENOG4105DZC cytosine deaminase G9174_RS01850 ENOG4106DTQ Protein TsgA homolog G9174_RS01855 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G9174_RS01860 ENOG4106195 uncharacterized protein yhfG G9174_RS01865 ENOG4105MZU cell filamentation protein G9174_RS01875 ENOG4105C8Y Acetylornithine aminotransferase G9174_RS01880 ENOG410613R integral membrane protein, YccS YhfK family G9174_RS01885 ENOG4107RYR Transcriptional regulator, Crp Fnr family G9174_RS01890 ENOG4108UKZ OsmC family G9174_RS01895 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) G9174_RS01905 ENOG4105DNZ Alpha Beta Hydrolase G9174_RS01910 ENOG4105C5H ABC transporter G9174_RS01915 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G9174_RS01920 ENOG4105CKD glutathione-regulated potassium-efflux system protein G9174_RS01925 ENOG4105VKU nucleicacid-binding protein G9174_RS01930 ENOG4108YZY peptidylprolyl cis-trans isomerase G9174_RS01935 ENOG4105VRX Protein slyX homolog G9174_RS01940 ENOG4108V1T peptidylprolyl cis-trans isomerase G9174_RS01945 ENOG4105WWK YheO domain protein G9174_RS01950 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) G9174_RS01955 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) G9174_RS01960 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) G9174_RS01965 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G9174_RS01970 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G9174_RS01975 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G9174_RS01980 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G9174_RS01985 ENOG4105W53 bacterioferritin-associated ferredoxin G9174_RS01990 ENOG4108UQY Iron-storage protein G9174_RS02005 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G9174_RS02010 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G9174_RS02020 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G9174_RS02025 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G9174_RS02030 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G9174_RS02035 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G9174_RS02040 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G9174_RS02045 ENOG41083MP 50s ribosomal protein l29 G9174_RS02050 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G9174_RS02055 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G9174_RS02060 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G9174_RS02075 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G9174_RS02080 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G9174_RS02090 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G9174_RS02095 ENOG4105VPB 50S ribosomal protein L30 G9174_RS02100 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G9174_RS02105 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G9174_RS02110 ENOG41067V7 50S ribosomal protein L36 G9174_RS02115 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G9174_RS02120 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G9174_RS02125 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G9174_RS02130 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G9174_RS02135 ENOG4108ZT0 50S ribosomal protein l17 G9174_RS02140 ENOG4105VTS DnaJ-like, subfamily C G9174_RS02145 ENOG4105W1Y Transcriptional regulator G9174_RS02150 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system G9174_RS02155 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G9174_RS02160 ENOG4105C1A potassium transporter peripheral membrane G9174_RS02165 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G9174_RS02170 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G9174_RS02175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G9174_RS02180 ENOG4105C79 DNA protecting protein DprA G9174_RS02190 ENOG4108WI1 Dna topoisomerase G9174_RS02195 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G9174_RS02200 ENOG4105E2X shikimate dehydrogenase G9174_RS02205 ENOG4105SG3 Protein of unknown function (DUF1488) G9174_RS02210 ENOG4108Z0R Transferase G9174_RS02240 ENOG4105XCM membrane LIPOPROTEIN G9174_RS02245 ENOG4105BZS acriflavin resistance protein G9174_RS02250 ENOG4105C1P efflux transporter, rnd family, mfp subunit G9174_RS02255 ENOG4108XG4 DNA-binding transcriptional regulator G9174_RS02260 ENOG4105DFP Integrase G9174_RS02275 ENOG4105XB7 anti-repressor protein G9174_RS02360 ENOG4105CAR Terminase, large subunit G9174_RS02375 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G9174_RS02380 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G9174_RS02385 ENOG4108IA2 Sodium pantothenate symporter G9174_RS02390 ENOG4105RG0 Membrane G9174_RS02395 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G9174_RS02400 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G9174_RS02410 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) G9174_RS02425 ENOG41062P1 Diguanylate cyclase phosphodiesterase G9174_RS02435 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G9174_RS02440 ENOG4105VQ7 Rod shape-determining protein MreD G9174_RS02445 ENOG4108Z03 MAF-like protein G9174_RS02450 ENOG4105C03 ribonuclease G9174_RS02455 ENOG4105QD6 exported protein G9174_RS02460 ENOG4105D1U peptidase U62 modulator of DNA gyrase G9174_RS02465 ENOG4105CR8 Transcriptional regulator G9174_RS02480 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) G9174_RS02485 ENOG4105UNR (Barnase) inhibitor G9174_RS02490 ENOG4105RID UPF0379 protein yhcN G9174_RS02495 ENOG4105RID UPF0379 protein yhcN G9174_RS02500 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) G9174_RS02505 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G9174_RS02510 ENOG4105C0H protease G9174_RS02515 ENOG4105C0H protease G9174_RS02520 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III G9174_RS02525 ENOG4105D6Z AFG1 family ATPase G9174_RS02530 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G9174_RS02545 ENOG4107MKT Stringent starvation protein a G9174_RS02550 ENOG4105KB2 stringent starvation protein b G9174_RS02555 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) G9174_RS02560 ENOG4105BZ8 glutamate synthase G9174_RS02565 ENOG4105CBC glutamate synthase G9174_RS02570 ENOG4105N5T Radical SAM Protein G9174_RS02575 ENOG4108I5G Major Facilitator superfamily G9174_RS02580 ENOG4105CPQ Dehydrogenase G9174_RS02585 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) G9174_RS02590 ENOG4105BZU Histidine kinase G9174_RS02595 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain G9174_RS02605 ENOG41080Z8 PHOSPHOCARRIER protein G9174_RS02610 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G9174_RS02615 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN G9174_RS02620 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA G9174_RS02625 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9174_RS02630 ENOG4108IUZ ABC transporter G9174_RS02635 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G9174_RS02640 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) G9174_RS02645 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase G9174_RS02650 ENOG4105C2X Arabinose 5-phosphate isomerase G9174_RS02655 ENOG4105FEU K -dependent Na -Ca exchanger G9174_RS02660 ENOG4105DHJ ABC, transporter G9174_RS02665 ENOG4105CY3 ABC transporter, permease G9174_RS02670 ENOG4107PE3 Mammalian cell entry related domain protein G9174_RS02675 ENOG4105E3I toluene tolerance G9174_RS02680 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane G9174_RS02685 ENOG4105VFK BolA family G9174_RS02690 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G9174_RS02695 ENOG4105HVQ Regulatory factor of maltose metabolism G9174_RS02700 ENOG4105EAH synthase G9174_RS02705 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G9174_RS02710 ENOG4105K46 50S ribosomal protein l27 G9174_RS02715 ENOG4105QYV Membrane G9174_RS02720 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G9174_RS02725 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase G9174_RS02730 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G9174_RS02735 ENOG4105HBR Rna-binding protein G9174_RS02740 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) G9174_RS02745 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G9174_RS02750 ENOG4105EEI dihydropteroate synthase G9174_RS02755 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G9174_RS02760 ENOG4105NTZ Preprotein translocase subunit SecG G9174_RS02775 ENOG4108UII YfaZ family G9174_RS02780 ENOG4108PNB DNA-binding transcriptional regulator G9174_RS02785 ENOG4105CDH Citrulline--aspartate ligase G9174_RS02795 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G9174_RS02800 ENOG4105CHV Transcription elongation factor NusA G9174_RS02805 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G9174_RS02810 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G9174_RS02815 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G9174_RS02820 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G9174_RS02825 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G9174_RS02840 ENOG4105C1J atp-dependent rna helicase G9174_RS02845 ENOG4105CIC tryptophan-specific transport protein G9174_RS02850 ENOG4105DEN Luciferase family G9174_RS02870 ENOG4108YYD acetyltransferase G9174_RS02875 ENOG41082IR Excinuclease ABC C subunit domain protein G9174_RS02880 ENOG4108ZPB UPF0306 protein G9174_RS02885 ENOG4107R7Y intracellular protease Pfpi family G9174_RS02890 ENOG4105K4T epimerase G9174_RS02895 ENOG4107S21 permease G9174_RS02900 ENOG4105W4M Transport-associated protein G9174_RS02905 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G9174_RS02910 ENOG41082RQ UPF0102 protein G9174_RS02915 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) G9174_RS02920 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G9174_RS02925 ENOG4107R3N Filamentation induced by cAMP protein fic G9174_RS02935 ENOG4107WTH Galactitol-1-phosphate dehydrogenase G9174_RS02940 ENOG4105DT3 PTS system, galactitol-specific IIc component G9174_RS02945 ENOG41090UW PTS System G9174_RS02950 ENOG41082GB PTS system galactitol-specific transporter subunit IIA G9174_RS02955 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of G9174_RS02960 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein G9174_RS02965 ENOG4105DM4 PTS System G9174_RS02970 ENOG4105DE4 1-phosphofructokinase G9174_RS02975 ENOG4105D2N Aldolase G9174_RS02980 ENOG4105E98 transcriptional regulator DeoR family G9174_RS02985 ENOG4107UEK pfkb domain protein G9174_RS02990 ENOG4105CTX dehydratase G9174_RS02995 ENOG4105DJB Major Facilitator Superfamily G9174_RS03000 ENOG4105CNV Aldolase G9174_RS03005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G9174_RS03010 ENOG4105BZW Glycerate kinase G9174_RS03030 ENOG4106D80 Uncharacterized protein YhaL G9174_RS03035 ENOG4108CNN domain protein G9174_RS03040 ENOG4105CWB LysR family transcriptional Regulator G9174_RS03045 ENOG4105KAF membrAne G9174_RS03050 ENOG4105CHF Glutathione S-transferase G9174_RS03055 ENOG4108VBZ doxx family G9174_RS03060 ENOG4105YJD G9174_RS03065 ENOG41090KG Inner membrane protein YqjE G9174_RS03070 ENOG4105NE1 Conserved Protein G9174_RS03075 ENOG4105WAY exported protein G9174_RS03080 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) G9174_RS03085 ENOG4106W5V Membrane G9174_RS03090 ENOG4107YCY Transcriptional regulator G9174_RS03095 ENOG4105DPW Major facilitator superfamily MFS_1 G9174_RS03105 ENOG4105CTX dehydratase G9174_RS03110 ENOG4105P66 Membrane G9174_RS03115 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) G9174_RS03120 ENOG4105DU1 integral membrane protein, terc G9174_RS03125 ENOG4105EE0 oxidoreductase G9174_RS03130 ENOG4108VKG metal-dependent hydrolase G9174_RS03145 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G9174_RS03150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G9174_RS03155 ENOG4107RYS Autoinducer-2 (AI-2) kinase G9174_RS03160 ENOG4105DKT Transcriptional regulator G9174_RS03165 ENOG4105C2J ABC transporter G9174_RS03170 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane G9174_RS03175 ENOG4105F5R ABC transporter G9174_RS03180 ENOG4105D4B ABC, transporter G9174_RS03185 ENOG41061GT Aldolase G9174_RS03190 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound G9174_RS03195 ENOG4105C8Y Acetylornithine aminotransferase G9174_RS03200 ENOG4105NTW Transcriptional regulator G9174_RS03205 ENOG4105Q26 Siderophore-interacting protein G9174_RS03220 ENOG4108UTZ Dihydroxyacetone kinase G9174_RS03225 ENOG4105CMT Dihydroxyacetone kinase G9174_RS03255 ENOG4105C0A alcohol dehydrogenase G9174_RS03270 ENOG4105YCI dehydratase medium subunit G9174_RS03275 ENOG4108ZFT Dehydratase small subunit G9174_RS03280 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit G9174_RS03285 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9174_RS03290 ENOG4105XXV Acid-resistance protein G9174_RS03295 ENOG4108YK4 Acid-resistance membrane protein G9174_RS03300 ENOG4108V08 YfdX protein G9174_RS03305 ENOG4105BZU Histidine kinase G9174_RS03310 ENOG4108WQH regulatoR G9174_RS03350 ENOG410693A DNA-binding protein G9174_RS03355 ENOG4105JXR Protein of unknown function (DUF3296) G9174_RS03375 ENOG4108BUD transposase G9174_RS03395 ENOG4108BUD transposase G9174_RS03410 ENOG4105EUV Phenol 2-monooxygenase G9174_RS03440 ENOG4108BUD transposase G9174_RS03445 ENOG4105ECI YeeC-like protein G9174_RS03450 ENOG4105F6A helicase G9174_RS03455 ENOG4105D85 methylase G9174_RS03480 ENOG4105F4K antigen 43 G9174_RS03485 ENOG4106H6R UPF0380 protein G9174_RS03490 ENOG4105MFG Antirestriction protein G9174_RS03495 ENOG4108YGG dna repair protein G9174_RS03505 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G9174_RS03535 ENOG4108VCA G U mismatch-specific DNA glycosylase G9174_RS03540 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9174_RS03545 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G9174_RS03555 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G9174_RS03565 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) G9174_RS03575 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) G9174_RS03580 ENOG4105CQM Urea amidohydrolase subunit alpha G9174_RS03585 ENOG4105KI2 Urea amidohydrolase subunit beta G9174_RS03590 ENOG4108YZ9 Urea amidohydrolase subunit gamma G9174_RS03595 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G9174_RS03610 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G9174_RS03615 ENOG4107ZVW dihydroneopterin aldolase G9174_RS03620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G9174_RS03625 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G9174_RS03630 ENOG4106MWK domain protein G9174_RS03635 ENOG4105I7R Adenylate cyclase G9174_RS03640 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G9174_RS03645 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) G9174_RS03660 ENOG4105W0Z cytoplasmic protein G9174_RS03665 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G9174_RS03675 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G9174_RS03680 ENOG4106032 Glutathionylspermidine synthase G9174_RS03685 ENOG4105F1G UPF0441 protein G9174_RS03695 ENOG41087AY ADP-Ribose pyrophosphatase G9174_RS03700 ENOG4108SX3 cytoplasmic protein G9174_RS03705 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G9174_RS03710 ENOG4105IPS esterase G9174_RS03715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9174_RS03720 ENOG4105VRH Antibiotic biosynthesis monooxygenase G9174_RS03725 ENOG4105NF4 modulator of drug activity G9174_RS03730 ENOG4105DHQ Histidine kinase G9174_RS03735 ENOG4105XJC Two component transcriptional regulator (Winged helix family G9174_RS03740 ENOG4105H4F exported protein G9174_RS03745 ENOG4105F4I Transcriptional regulator G9174_RS03750 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9174_RS03755 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase G9174_RS03760 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) G9174_RS03765 ENOG4105CCT upf0313 protein G9174_RS03775 ENOG4105CV8 reductase G9174_RS03780 ENOG4108I6A alcohol dehydrogenase G9174_RS03785 ENOG4105CF7 AraC family transcriptional regulator G9174_RS03790 ENOG4108K81 inner membrane protein YghB G9174_RS03795 ENOG4105C28 cystathionine G9174_RS03800 ENOG4105CWK Biopolymer transport protein, ExbB G9174_RS03805 ENOG4108ZZF transport protein (ExbD) G9174_RS03810 ENOG4105CT4 transporter G9174_RS03815 ENOG4105E4I Glycoside hydrolase family 28 G9174_RS03820 ENOG4108TEB UPF0114 protein G9174_RS03830 ENOG410900S Protein of unknown function (DUF2623) G9174_RS03835 ENOG4105CYM Glutathione S-transferase G9174_RS03850 ENOG4106032 Glutathionylspermidine synthase G9174_RS03855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9174_RS03875 ENOG4105CC0 LysR family Transcriptional regulator G9174_RS03880 ENOG4105C28 cystathionine G9174_RS03920 ENOG4105CDU Replicative dna helicase G9174_RS04135 ENOG4105HVQ Regulatory factor of maltose metabolism G9174_RS04145 ENOG4105VEQ Cold shock protein G9174_RS04150 ENOG4105HVQ Regulatory factor of maltose metabolism G9174_RS04190 ENOG4105MFG Antirestriction protein G9174_RS04225 ENOG4108UQV Membrane G9174_RS04230 ENOG4105CXN decarboxylase G9174_RS04235 ENOG4105EAA nucleoside G9174_RS04240 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division G9174_RS04245 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) G9174_RS04250 ENOG4105CEN a g-specific adenine glycosylase G9174_RS04255 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G9174_RS04260 ENOG41090ED Protein with unknown function (DUF469) G9174_RS04265 ENOG4105K33 Periplasmic Protein G9174_RS04270 ENOG4105CSA Coproporphyrinogen iii oxidase G9174_RS04275 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G9174_RS04280 ENOG4105VZ9 UPF0235 protein G9174_RS04285 ENOG4108VIA integral membrane protein G9174_RS04290 ENOG4105DFA alanine racemase domain protein G9174_RS04295 ENOG4105CZX twitching motility protein G9174_RS04300 ENOG41086KC Transcriptional regulator G9174_RS04305 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G9174_RS04310 ENOG4108UJU UPF0301 protein G9174_RS04315 ENOG4105D7Z glutathione synthase G9174_RS04320 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G9174_RS04325 ENOG4105RWS endonuclease I G9174_RS04330 ENOG4105GPY SprT protein G9174_RS04335 ENOG4107QNK )-transporter G9174_RS04340 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G9174_RS04360 ENOG4105CYW agmatinase G9174_RS04385 ENOG4105CHR reductase G9174_RS04390 ENOG4108FUF Transcriptional regulator, IclR family G9174_RS04400 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase G9174_RS04420 ENOG4105CHR reductase G9174_RS04425 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) G9174_RS04440 ENOG4105J5J Outer membrane porin G9174_RS04445 ENOG4108K0D peptidase, M48 G9174_RS04450 ENOG4105CV1 Transketolase (EC 2.2.1.1) G9174_RS04455 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G9174_RS04465 ENOG4105D2N Aldolase G9174_RS04470 ENOG4105D64 Mechanosensitive ion channel G9174_RS04475 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G9174_RS04480 ENOG4105MPN Membrane G9174_RS04485 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G9174_RS04490 ENOG4105E66 phosphoriboisomerase A G9174_RS04495 ENOG4108JQ1 Dehydrogenase G9174_RS04500 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G9174_RS04510 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) G9174_RS04515 ENOG4105E07 UPF0149 protein G9174_RS04520 ENOG4107RAQ aminopeptidase G9174_RS04525 ENOG4105D0A hydroxylase G9174_RS04530 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G9174_RS04535 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G9174_RS04540 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G9174_RS04545 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G9174_RS04550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G9174_RS04555 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G9174_RS04575 ENOG4105CS2 ec 3.2.1.21 G9174_RS04580 ENOG4108Q3X Transcriptional regulator G9174_RS04585 ENOG4105N5Z UPF0267 protein G9174_RS04590 ENOG4108UT2 hemolysin iii G9174_RS04600 ENOG4105Y75 tpr repeat protein G9174_RS04605 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB G9174_RS04610 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) G9174_RS04615 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G9174_RS04620 ENOG4105T95 Thiol disulfide interChange protein G9174_RS04625 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G9174_RS04635 ENOG4105CRK lysyL-tRNA synthetase G9174_RS04640 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) G9174_RS04645 ENOG4108K5P (LipO)protein G9174_RS04655 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9174_RS04670 ENOG4105CPC Aldo Keto reductase G9174_RS04685 ENOG4105W7K Transcriptional regulator G9174_RS04705 ENOG4107R5R arsenical pump membrane protein G9174_RS04710 ENOG4105K89 arsenate reductase G9174_RS04715 ENOG4105DUX Transporter G9174_RS04720 ENOG4105V2F Uncharacterized protein yoac G9174_RS04725 ENOG4105ETP RND efflux system, outer membrane lipoprotein G9174_RS04730 ENOG4108MI0 Resistance protein G9174_RS04735 ENOG4105J12 Multidrug resistance protein mdtN G9174_RS04745 ENOG4105VR1 Pfam:DUF1271 G9174_RS04750 ENOG410830R acetyltransferase G9174_RS04760 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin G9174_RS04765 ENOG4108T65 Fimbrial G9174_RS04770 ENOG4108SQA Fimbrial G9174_RS04775 ENOG4105CW0 outer membrane usher protein G9174_RS04780 ENOG4108NAE Fimbrial chaperone protein G9174_RS04785 ENOG4108S54 Fimbrial protein G9174_RS04790 ENOG4108RQP Major type 1 subunit fimbrin G9174_RS04795 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off G9174_RS04800 ENOG4108W9T type 1 fimbriae regulatory protein G9174_RS04805 ENOG4105D7X high-affinity nickel-transporter G9174_RS04810 ENOG4108ZT1 Transcriptional regulator G9174_RS04815 ENOG4108KTG Membrane protein, drug metabolite transporter G9174_RS04825 ENOG4108T1W Fimbrial subunit type 3 G9174_RS04865 ENOG4107S5I aldo keto reductase G9174_RS04870 ENOG4108MHD transport protein G9174_RS04880 ENOG4105C5Q Transcriptional regulator G9174_RS04885 ENOG4105CHU acetyl-coa acetyltransferase G9174_RS04890 ENOG4108QGT oligogalacturonate-specific porin G9174_RS04895 ENOG4105CAZ oligogalacturonide lyase G9174_RS04900 ENOG4105CHR reductase G9174_RS04905 ENOG4107QNK )-transporter G9174_RS04910 ENOG4106NDP Transcriptional regulator G9174_RS04920 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G9174_RS04925 ENOG4108HKT sucrose-6-phosphate hydrolase G9174_RS04940 ENOG4108IJ9 (ABC) transporter G9174_RS04945 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G9174_RS04950 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G9174_RS04955 ENOG4105YKW G9174_RS04965 ENOG4105RQF LysR family Transcriptional regulator G9174_RS04975 ENOG4105DDV Transcriptional regulator (LacI family G9174_RS04980 ENOG4105CK1 PTS System G9174_RS04985 ENOG4105CS2 ec 3.2.1.21 G9174_RS04990 ENOG4107YCY Transcriptional regulator G9174_RS05000 ENOG41060NJ transcriptional regulator G9174_RS05005 ENOG4105CEY Amp-dependent synthetase and ligase G9174_RS05010 ENOG4107S74 Lysophospholipid transporter LplT G9174_RS05015 ENOG4105CPC Aldo Keto reductase G9174_RS05020 ENOG4105SUV lipoprotein YgdR G9174_RS05025 ENOG4105EE5 Membrane protein terC G9174_RS05030 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) G9174_RS05040 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G9174_RS05045 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase G9174_RS05050 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G9174_RS05055 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G9174_RS05060 ENOG4105IPU prepilin peptidase dependent protein A G9174_RS05065 ENOG4105JCS prepilin peptidase dependent protein G9174_RS05070 ENOG4105SEN Protein of unknown function (DUF2509) G9174_RS05075 ENOG4105RVB Prepilin peptidase dependent protein c G9174_RS05080 ENOG4105DSY exodeoxyribonuclease V, gamma G9174_RS05085 ENOG4107QXK peptidase G9174_RS05090 ENOG4107QKA exodeoxyribonuclease V beta G9174_RS05095 ENOG4107QYX exodeoxyribonuclease v alpha G9174_RS05105 ENOG4107QZM n-acetylglutamate synthase G9174_RS05110 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G9174_RS05115 ENOG4107QZB decarboxylase G9174_RS05120 ENOG4105JZC GHMP kinase G9174_RS05125 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G9174_RS05130 ENOG4105KTW ethanolamine utilization protein G9174_RS05135 ENOG4105M3W utilization protein G9174_RS05145 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) G9174_RS05150 ENOG4105C0A alcohol dehydrogenase G9174_RS05155 ENOG4108EKI Dehydrogenase G9174_RS05165 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml G9174_RS05180 ENOG4105KNY Microcompartments protein G9174_RS05185 ENOG4105KNY Microcompartments protein G9174_RS05195 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit G9174_RS05200 ENOG4108ZFT Dehydratase small subunit G9174_RS05205 ENOG4105YCI dehydratase medium subunit G9174_RS05210 ENOG4105DMB glycerol dehydratase G9174_RS05215 ENOG4105EHR propanediol utilization protein pduB G9174_RS05220 ENOG4105KNY Microcompartments protein G9174_RS05225 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9174_RS05230 ENOG4107XVH Transcriptional regulator G9174_RS05235 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G9174_RS05240 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G9174_RS05245 ENOG41081F0 Precorrin-8x methylmutase G9174_RS05250 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) G9174_RS05255 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase G9174_RS05260 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase G9174_RS05265 ENOG4105CIA precorrin-4 C(11)-methyltransferase G9174_RS05270 ENOG4108P62 biosynthesis protein (CbiG) G9174_RS05275 ENOG4105E4R Precorrin-3B C17-methyltransferase G9174_RS05280 ENOG4105QUC reductase G9174_RS05285 ENOG4107PPM cobalt chelatase G9174_RS05290 ENOG4105DVK Precorrin-2 c20-methyltransferase G9174_RS05295 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) G9174_RS05300 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) G9174_RS05305 ENOG4108V4M Cobalt abc transporter G9174_RS05315 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G9174_RS05320 ENOG4108YZT Adenosylcobinamide kinase G9174_RS05345 ENOG4105CA3 membrane-bound lytic murein transglycosylase G9174_RS05350 ENOG4105CUZ uba thif-type nad fad binding protein G9174_RS05355 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) G9174_RS05360 ENOG4105C9B Cysteine desulfurase G9174_RS05365 ENOG4105M5B (LipO)protein G9174_RS05370 ENOG4105ETT transcriptional Regulator, LysR family G9174_RS05375 ENOG4105M08 Membrane G9174_RS05385 ENOG4107EDW L-fucose operon activator G9174_RS05390 ENOG4105NWF RbsD or FucU transport G9174_RS05395 ENOG4105CMG Carbohydrate kinase G9174_RS05400 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) G9174_RS05405 ENOG4105EDR glucose galactose transporter G9174_RS05410 ENOG4107W7X Aldolase G9174_RS05415 ENOG4105C0A alcohol dehydrogenase G9174_RS05420 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease G9174_RS05425 ENOG4108JU7 Transcriptional regulator G9174_RS05435 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G9174_RS05450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G9174_RS05455 ENOG4108UMI ABC transporter, permease G9174_RS05460 ENOG4105D01 (LipO)protein G9174_RS05465 ENOG41079KZ Major Facilitator Superfamily G9174_RS05475 ENOG4105GVF (ABC) transporter G9174_RS05480 ENOG4105EJQ L-serine dehydratase G9174_RS05485 ENOG4105C44 Serine transporter G9174_RS05490 ENOG4105EWT decarboxylase family G9174_RS05495 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G9174_RS05500 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) G9174_RS05505 ENOG4105WP7 tRNA pseudouridine synthase C G9174_RS05510 ENOG4105DR9 pseudouridine synthase G9174_RS05515 ENOG4105QDK Flavodoxin G9174_RS05520 ENOG4105DJB Major Facilitator Superfamily G9174_RS05525 ENOG4105EQX glucarate dehydratase G9174_RS05530 ENOG4105EQX glucarate dehydratase G9174_RS05535 ENOG4105BZW Glycerate kinase G9174_RS05540 ENOG4105BZU Histidine kinase G9174_RS05545 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G9174_RS05550 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G9174_RS05555 ENOG4105DXN mazG family G9174_RS05560 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G9174_RS05565 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G9174_RS05575 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G9174_RS05580 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase G9174_RS05585 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G9174_RS05590 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G9174_RS05595 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G9174_RS05600 ENOG4108MXK alkaline phosphatase isozyme conversion G9174_RS05605 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G9174_RS05610 ENOG4105C11 sulfate adenylyltransferase), subunit 2 G9174_RS05620 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) G9174_RS05625 ENOG4105N0Z inner membrane protein ygbE G9174_RS05630 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G9174_RS05635 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G9174_RS05640 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G9174_RS05645 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) G9174_RS05655 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G9174_RS05660 ENOG4108K5P (LipO)protein G9174_RS05665 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9174_RS05690 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G9174_RS05695 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G9174_RS05700 ENOG4105KZM cytoplasmic protein G9174_RS05710 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G9174_RS05730 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G9174_RS05735 ENOG4105EHG Permease protein G9174_RS05740 ENOG4107R4I Periplasmic binding protein G9174_RS05745 ENOG4106QJH hemin transport protein G9174_RS05765 ENOG4108N2Y auxin Efflux G9174_RS05775 ENOG4105VXR cytoplasmic protein G9174_RS05780 ENOG4105CC5 ABC transporter G9174_RS05785 ENOG4105CC5 ABC transporter G9174_RS05790 ENOG4105DIK (ABC) transporter G9174_RS05795 ENOG4105DSE periplasmic solute binding protein G9174_RS05800 ENOG4105DDV Transcriptional regulator (LacI family G9174_RS05805 ENOG4105DKQ ROK family G9174_RS05810 ENOG4105VCP PTS System G9174_RS05815 ENOG4105CK1 PTS System G9174_RS05820 ENOG4105VZJ PTS System G9174_RS05825 ENOG4105CK1 PTS System G9174_RS05830 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G9174_RS05840 ENOG4105CS2 ec 3.2.1.21 G9174_RS05850 ENOG4105C45 hydrogenase expression formation protein (HypE) G9174_RS05855 ENOG4105CQS hydrogenase expression formation protein HypD G9174_RS05860 ENOG41083WG hydrogenase assembly chaperone G9174_RS05865 ENOG4107RSS Hydrogenase accessory protein HypB G9174_RS05870 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G9174_RS05875 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA G9174_RS05880 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) G9174_RS05885 ENOG4107R30 NADH dehydrogenase G9174_RS05890 ENOG4107TDF Formate hydrogenlyase subunit 4 G9174_RS05895 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9174_RS05900 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit G9174_RS05905 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit G9174_RS05910 ENOG4105I6X formate hydrogenlyase maturation G9174_RS05915 ENOG4108MG9 hydrogenase 3 maturation protease G9174_RS05925 ENOG4105CS2 ec 3.2.1.21 G9174_RS05930 ENOG4105C5Y PTS System G9174_RS05935 ENOG4105DDV Transcriptional regulator (LacI family G9174_RS05940 ENOG4108RC0 Electron transport protein G9174_RS05945 ENOG4105C8H hydrogenase maturation protein Hypf G9174_RS05955 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase G9174_RS05960 ENOG4105CNW domain protein G9174_RS05965 ENOG4108JUA Transcriptional regulator G9174_RS05975 ENOG410804X Transcriptional regulator G9174_RS05980 ENOG4105J92 DNA-binding transcriptional activator GutM G9174_RS05985 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase G9174_RS05990 ENOG4105VI0 Pts system, glucitol sorbitol-specific G9174_RS05995 ENOG4105DZY Pts system, glucitol sorbitol-specific G9174_RS06000 ENOG410787A Pts system, glucitol sorbitol-specific G9174_RS06005 ENOG4105CVE Lytic murein transglycosylase G9174_RS06015 ENOG4105CC5 ABC transporter G9174_RS06020 ENOG4105DSE periplasmic solute binding protein G9174_RS06025 ENOG4107TH8 cina domain protein G9174_RS06030 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G9174_RS06035 ENOG4105Y3E Modulates RecA activity (By similarity) G9174_RS06040 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G9174_RS06045 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) G9174_RS06075 ENOG4105K3G Periplasmic Protein G9174_RS06080 ENOG4107VXZ Hydrolase G9174_RS06085 ENOG4105W39 Membrane G9174_RS06090 ENOG4105D9M gamma-glutamylcysteine synthetase G9174_RS06105 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G9174_RS06110 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9174_RS06115 ENOG4105CW7 secretion protein, HlyD family G9174_RS06120 ENOG4105NTK Transcriptional repressor Mpra G9174_RS06125 ENOG4105ZED uncharacterized protein ygaH G9174_RS06130 ENOG4108UMN azlc family G9174_RS06135 ENOG4105GIJ Glycine betaine G9174_RS06140 ENOG4108HQS Glycine betaine G9174_RS06145 ENOG4108IJ7 Glycine betaine G9174_RS06150 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G9174_RS06155 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G9174_RS06160 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) G9174_RS06165 ENOG4105WAZ (Glutaredoxin-like protein) NrdH G9174_RS06170 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9174_RS06175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9174_RS06180 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) G9174_RS06185 ENOG4108WMJ Protein of unknown function (DUF2002) G9174_RS06190 ENOG4108RNS Exports L-alanine (By similarity) G9174_RS06195 ENOG4108X73 DNA- binding protein G9174_RS06210 ENOG4108V62 Rhodanese domain protein G9174_RS06215 ENOG41080HT Transcriptional regulator, arsr family G9174_RS06225 ENOG4105CC0 LysR family Transcriptional regulator G9174_RS06230 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G9174_RS06235 ENOG4105C26 Dehydrogenase G9174_RS06240 ENOG4105X0I Fimbrial G9174_RS06245 ENOG4108VCD Chaperone G9174_RS06250 ENOG4105CW0 outer membrane usher protein G9174_RS06265 ENOG4105CW0 outer membrane usher protein G9174_RS06270 ENOG4106P2F Pfam:Pili_assembly_C G9174_RS06275 ENOG4106EAR Fimbrial protein G9174_RS06280 ENOG4108WQH regulatoR G9174_RS06295 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G9174_RS06300 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G9174_RS06305 ENOG4105MP9 class II Aldolase G9174_RS06315 ENOG4106TNF Periplasmic binding protein G9174_RS06330 ENOG4105CYW agmatinase G9174_RS06335 ENOG4105EVZ LysR family transcriptional regulator G9174_RS06350 ENOG4105C1P efflux transporter, rnd family, mfp subunit G9174_RS06355 ENOG4105UEI Transcriptional Regulator AraC Family G9174_RS06380 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G9174_RS06385 ENOG4108Z1B Cyclase dehydrase G9174_RS06395 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G9174_RS06400 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G9174_RS06405 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G9174_RS06410 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G9174_RS06415 ENOG4108JU6 CBS domain protein G9174_RS06420 ENOG4106KVJ cytochrome C assembly protein G9174_RS06425 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G9174_RS06430 ENOG4105K5M 30s ribosomal protein S16 G9174_RS06435 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G9174_RS06440 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G9174_RS06445 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G9174_RS06460 ENOG41090EK ompa motb domain protein G9174_RS06465 ENOG4108KHX Diguanylate cyclase G9174_RS06470 ENOG4108WS1 G9174_RS06475 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G9174_RS06480 ENOG4105EHE chorismate mutase- prephenate dehydrogenase G9174_RS06490 ENOG4105CQC Prephenate dehydratase G9174_RS06500 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA G9174_RS06505 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G9174_RS06510 ENOG4105C34 Pseudouridine synthase G9174_RS06515 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G9174_RS06520 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G9174_RS06545 ENOG4105CSH Transporter G9174_RS06550 ENOG4105T42 (LipO)protein G9174_RS06555 ENOG4105JIM Phosphatidylserine synthase G9174_RS06560 ENOG4105CD5 CoA-binding domain protein G9174_RS06565 ENOG4106IUH DTW domain containing protein G9174_RS06570 ENOG4105K63 Thioredoxin G9174_RS06575 ENOG4105EIB trna rrna methyltransferase G9174_RS06580 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G9174_RS06585 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) G9174_RS06590 ENOG4105C1J atp-dependent rna helicase G9174_RS06595 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) G9174_RS06600 ENOG4108IYU L-aspartate oxidase G9174_RS06615 ENOG41069PW sigma-e factor negative regulatory protein G9174_RS06620 ENOG4105VQK sigma E regulatory protein, MucB RseB G9174_RS06625 ENOG4105WMJ Positive regulator of sigma E, RseC MucC G9174_RS06630 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G9174_RS06635 ENOG4105C3F Signal peptidase i G9174_RS06640 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G9174_RS06645 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G9174_RS06650 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G9174_RS06655 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G9174_RS06660 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G9174_RS06665 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G9174_RS06670 ENOG4106G6Q Transcriptional regulator G9174_RS06675 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB G9174_RS06680 ENOG4108Z6B deaminase G9174_RS06685 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) G9174_RS06690 ENOG4108ETH Formylglycinamide ribotide synthetase G9174_RS06695 ENOG4107WP9 Histidine kinase G9174_RS06700 ENOG4108SKK alpha helix protein G9174_RS06705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G9174_RS06710 ENOG4108YZA Nitrogen regulatory protein pii G9174_RS06715 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9174_RS06720 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G9174_RS06725 ENOG4108SB3 DoxX Family G9174_RS06730 ENOG4108NZE NAGC-like transcriptional regulator G9174_RS06735 ENOG4107HQ7 repeat protein G9174_RS06740 ENOG4107QNK )-transporter G9174_RS06745 ENOG4108ZKT aldose 1-epimerase G9174_RS06750 ENOG4105D8G Major Facilitator superfamily G9174_RS06755 ENOG4108MN2 Stationary phase inducible protein CsiE G9174_RS06760 ENOG41065CD Exported protein G9174_RS06765 ENOG4105D7X high-affinity nickel-transporter G9174_RS06775 ENOG4105ECY inositol monophosphatase G9174_RS06780 ENOG4105CVS RNA methyltransferase TrmH family, group 1 G9174_RS06785 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G9174_RS06790 ENOG4105C3J Cysteine desulfurase G9174_RS06795 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G9174_RS06800 ENOG4108Z4V iron-sulfur cluster assembly G9174_RS06805 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) G9174_RS06810 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G9174_RS06815 ENOG4108ZIT Ferredoxin, 2FE-2S G9174_RS06820 ENOG4105WVQ Fe-S assembly protein IscX G9174_RS06825 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G9174_RS06830 ENOG4105YYA enhanced serine sensitivity protein SseB G9174_RS06840 ENOG4105KHC sulfurtransferase G9174_RS06845 ENOG4105DN3 alpha-2-macroglobulin domain protein G9174_RS06850 ENOG4108JQB penicillin-binding protein 1C G9174_RS06855 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G9174_RS06860 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G9174_RS06865 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) G9174_RS06870 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G9174_RS06880 ENOG4105N21 Membrane G9174_RS06885 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G9174_RS06890 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G9174_RS06900 ENOG4105VPD cellular component movement G9174_RS06905 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G9174_RS06910 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G9174_RS06915 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G9174_RS06925 ENOG4105C4X radical SAM domain protein G9174_RS06940 ENOG41062G3 Protein of unknown function (DUF2633) G9174_RS06945 ENOG4105BZU Histidine kinase G9174_RS06950 ENOG4105C9X ppx gppa phosphatase G9174_RS06955 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G9174_RS06960 ENOG4108V3E phosphoribosylglycinamide formyltransferase G9174_RS06965 ENOG4105CXB phosphoribosylaminoimidazole synthetase G9174_RS06970 ENOG41066F8 ROK family G9174_RS06975 ENOG4105CS2 ec 3.2.1.21 G9174_RS06980 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G9174_RS06985 ENOG4105C2W permease G9174_RS06990 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) G9174_RS07000 ENOG4105K89 arsenate reductase G9174_RS07005 ENOG4105ERG peptidase m48, ste24p G9174_RS07015 ENOG4105C02 permease G9174_RS07020 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G9174_RS07025 ENOG4105RH4 Glycine cleavage system transcriptional repressor G9174_RS07030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G9174_RS07035 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G9174_RS07040 ENOG4105C8V SAICAR synthetase G9174_RS07045 ENOG4105CGZ zinc metallopeptidase G9174_RS07050 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) G9174_RS07055 ENOG4106KED esterase YpfH G9174_RS07060 ENOG4105XYK UPF0370 protein G9174_RS07065 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G9174_RS07070 ENOG4105KUZ arsenate reductase G9174_RS07080 ENOG4105BZS acriflavin resistance protein G9174_RS07085 ENOG4105BZ8 glutamate synthase G9174_RS07090 ENOG4107VIJ nudix hydrolase G9174_RS07095 ENOG4108PVD exported protein G9174_RS07100 ENOG4105CV1 Transketolase (EC 2.2.1.1) G9174_RS07105 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G9174_RS07110 ENOG4105C6K Malic enzyme G9174_RS07115 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place G9174_RS07120 ENOG4106S4J ethanolamine utilization protein EutP G9174_RS07125 ENOG4105NDK ethanolamine utilization protein G9174_RS07130 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase G9174_RS07135 ENOG4108IJ2 phosphate acetyltransferase G9174_RS07140 ENOG4105KNY Microcompartments protein G9174_RS07145 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml G9174_RS07150 ENOG4108EKI Dehydrogenase G9174_RS07155 ENOG4107YMV ethanolamine utilization protein G9174_RS07160 ENOG4105C0A alcohol dehydrogenase G9174_RS07165 ENOG4105ENY Ethanolamine utilization protein eutH G9174_RS07170 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase G9174_RS07175 ENOG4105CPD ethanolamine ammonia-lyase G9174_RS07185 ENOG4106D67 ethanolamine utilization protein G9174_RS07190 ENOG4108X49 Ethanolamine utilization protein EutK G9174_RS07195 ENOG4108K3Z AraC family transcriptional regulator G9174_RS07200 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) G9174_RS07205 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase G9174_RS07210 ENOG4108R6G acetyltransferase G9174_RS07215 ENOG4105QZU Inner membrane protein YfeZ G9174_RS07220 ENOG4105E7K (LipO)protein G9174_RS07225 ENOG4105EZR dyp-type peroxidase family protein G9174_RS07235 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein G9174_RS07240 ENOG4108I5D sulfate abc transporter G9174_RS07245 ENOG4105ECW sulfate abc transporter G9174_RS07250 ENOG4108IJ6 ABC transporter G9174_RS07255 ENOG4105C6T cysteine synthase G9174_RS07260 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein G9174_RS07265 ENOG4105CSW GntR family transcriptional regulator G9174_RS07270 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) G9174_RS07280 ENOG4105C5Y PTS System G9174_RS07285 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G9174_RS07290 ENOG4105KZ7 phosphocarrier protein hpr G9174_RS07295 ENOG4105C6T cysteine synthase G9174_RS07300 ENOG4105EXN Sulfate transport protein CysZ G9174_RS07305 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) G9174_RS07310 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G9174_RS07315 ENOG4105VRT cytoplasmic protein G9174_RS07320 ENOG4105DHU Bile acid G9174_RS07325 ENOG4108M0I Transcriptional regulator G9174_RS07350 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G9174_RS07355 ENOG4105GXM Putative transcription regulator (DUF1323) G9174_RS07360 ENOG4105HZG regulatoR G9174_RS07375 ENOG4108KMM Diguanylate cyclase G9174_RS07380 ENOG4105D9N nucleoside G9174_RS07385 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G9174_RS07390 ENOG4109076 Conserved Protein G9174_RS07395 ENOG4105CPC Aldo Keto reductase G9174_RS07400 ENOG4107RA9 decarboxylase G9174_RS07410 ENOG4105CHC glucokinase (EC 2.7.1.2) G9174_RS07415 ENOG4105DY9 regulatoR G9174_RS07420 ENOG4108HRK Histidine kinase G9174_RS07435 ENOG4105CHM Aminotransferase G9174_RS07445 ENOG4105DJ2 Major Facilitator Superfamily G9174_RS07450 ENOG4107Y2X deaminase G9174_RS07455 ENOG4105DND Transcriptional regulator G9174_RS07560 ENOG4105CDU Replicative dna helicase G9174_RS07595 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi G9174_RS07600 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 G9174_RS07650 ENOG4108N0N Phage Terminase Large Subunit G9174_RS07655 ENOG4107ZQ5 Phage-associated protein, HI1409 family G9174_RS07730 ENOG4105E4C Lytic transglycosylase catalytic G9174_RS07785 ENOG410685N tail fiber protein G9174_RS07790 ENOG4105UZW Tail fiber assembly protein G9174_RS07805 ENOG4105DFP Integrase G9174_RS07815 ENOG4105S64 Formate nitrite transporter G9174_RS07820 ENOG410903C (LipO)protein G9174_RS07825 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation G9174_RS07830 ENOG4105KZW UPF0381 protein G9174_RS07835 ENOG4105CHU acetyl-coa acetyltransferase G9174_RS07840 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G9174_RS07845 ENOG4108BY2 phosphohistidine phosphatase G9174_RS07850 ENOG4108DG9 Smr protein MutS2 G9174_RS07855 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G9174_RS07860 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G9174_RS07865 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) G9174_RS07870 ENOG4105EJ9 Membrane G9174_RS07875 ENOG4108BPE -transporting atpase G9174_RS07880 ENOG4105MH2 YfcL protein G9174_RS07885 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G9174_RS07890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G9174_RS07895 ENOG4105F9N Major Facilitator Superfamily G9174_RS07900 ENOG4106WZ1 flagella biosynthesis regulator G9174_RS07910 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G9174_RS07915 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G9174_RS07920 ENOG4105DQR SNARE associated Golgi G9174_RS07925 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) G9174_RS07930 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G9174_RS07935 ENOG4108S3P Sporulation domain protein G9174_RS07940 ENOG4105E96 Colicin v production protein G9174_RS07945 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G9174_RS07950 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G9174_RS07960 ENOG4105E89 ABC transporter G9174_RS07965 ENOG4105E89 ABC transporter G9174_RS07970 ENOG4105DSP amino acid AbC transporter G9174_RS07975 ENOG4106YG3 ABC transporter G9174_RS07980 ENOG4108JEH abc transporter atp-binding protein G9174_RS07985 ENOG4105KNA -acetyltransferase G9174_RS07995 ENOG4105ECP epimerase G9174_RS08000 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase G9174_RS08005 ENOG4105CYM Glutathione S-transferase G9174_RS08010 ENOG4108SHQ Glutathione S-transferase G9174_RS08015 ENOG4108RE9 Phosphodiesterase G9174_RS08020 ENOG4105PTV Nudix Hydrolase G9174_RS08025 ENOG4105C6K Malic enzyme G9174_RS08030 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G9174_RS08035 ENOG4105PQ6 UPF0208 membrane protein G9174_RS08045 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 G9174_RS08050 ENOG4107QWE )-transporter G9174_RS08055 ENOG4105DK2 UPF0207 protein G9174_RS08060 ENOG4105CHM Aminotransferase G9174_RS08065 ENOG4107NQ8 LysR family Transcriptional regulator G9174_RS08070 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G9174_RS08075 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9174_RS08080 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9174_RS08085 ENOG4105GKE subunit e G9174_RS08090 ENOG4107QIZ NADH dehydrogenase G9174_RS08095 ENOG4108IEH NADH dehydrogenase subunit g G9174_RS08100 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G9174_RS08110 ENOG4107UFS subunit j G9174_RS08115 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9174_RS08120 ENOG4105D65 subunit l G9174_RS08125 ENOG4105C8S subunit m G9174_RS08130 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9174_RS08135 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G9174_RS08140 ENOG4107YB6 acetyltransferase, (GNAT) family G9174_RS08145 ENOG4105E4F Isochorismate synthase G9174_RS08150 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) G9174_RS08155 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) G9174_RS08160 ENOG4108IPT Naphthoate synthase G9174_RS08165 ENOG4105DNI Converts SHCHC to OSB (By similarity) G9174_RS08170 ENOG4105CEY Amp-dependent synthetase and ligase G9174_RS08180 ENOG4105DNE Transposase G9174_RS08185 ENOG4108UII YfaZ family G9174_RS08190 ENOG4108EWA cinA-like protein G9174_RS08195 ENOG4107258 Transcriptional regulator G9174_RS08205 ENOG4105EKQ RNA-directed DNA polymerase G9174_RS08215 ENOG4105CSP Major Facilitator Superfamily G9174_RS08220 ENOG4105CNV Aldolase G9174_RS08225 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G9174_RS08230 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B G9174_RS08235 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A G9174_RS08240 ENOG4105CXY transporter G9174_RS08245 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G9174_RS08250 ENOG4105XPH Ferredoxin G9174_RS08255 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G9174_RS08260 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G9174_RS08265 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G9174_RS08270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9174_RS08275 ENOG4105BZU Histidine kinase G9174_RS08280 ENOG41068CG regulatoR G9174_RS08285 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC G9174_RS08300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G9174_RS08305 ENOG4105CF1 Alkylated DNA repair protein G9174_RS08310 ENOG4105IBP Cyclic peptide transporter G9174_RS08315 ENOG4105CJW magnesium transporter G9174_RS08320 ENOG4105CHH sulfate transporter G9174_RS08335 ENOG4105F4G Membrane G9174_RS08345 ENOG4105E68 Sulfatase G9174_RS08350 ENOG4105PAN UPF0352 protein G9174_RS08355 ENOG4106V8H Nucleoid-associated protein G9174_RS08360 ENOG4105N2W Transcriptional regulator G9174_RS08365 ENOG4107VIJ nudix hydrolase G9174_RS08380 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G9174_RS08385 ENOG4105CFI type iii restriction protein res subunit G9174_RS08390 ENOG4105I08 Pseudouridine synthase G9174_RS08395 ENOG4105C2C drug resistance transporter, Bcr CflA G9174_RS08400 ENOG4105HG6 G9174_RS08405 ENOG4108JQ5 ABC transporter G9174_RS08410 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G9174_RS08415 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G9174_RS08420 ENOG4105E43 Extracellular solute-binding protein, family 5 G9174_RS08425 ENOG4105CXC rtn protein G9174_RS08430 ENOG4107TT5 NLP P60 protein G9174_RS08435 ENOG41076MN Phosphoesterase, PA-phosphatase related G9174_RS08440 ENOG4105CKI cobalamin synthesis protein G9174_RS08445 ENOG4105DEI Mannitol dehydrogenase G9174_RS08450 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) G9174_RS08460 ENOG4105KRS Proteinase inhibitor G9174_RS08465 ENOG4105S8Q sugar efflux transporter G9174_RS08470 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein G9174_RS08475 ENOG4105DE4 1-phosphofructokinase G9174_RS08480 ENOG4105DM4 PTS System G9174_RS08485 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) G9174_RS08490 ENOG4105HMI Membrane G9174_RS08495 ENOG4105DUM transcriptional regulator, lysR family G9174_RS08500 ENOG4108IQI permease G9174_RS08510 ENOG4105D05 Receptor G9174_RS08520 ENOG4105EUJ GTP cyclohydrolase i G9174_RS08525 ENOG4105DHF Membrane G9174_RS08530 ENOG41060NJ transcriptional regulator G9174_RS08540 ENOG4105C2J ABC transporter G9174_RS08545 ENOG4107SDZ Galactoside transport system permease protein mglC G9174_RS08550 ENOG4107GZ4 SanA protein G9174_RS08555 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) G9174_RS08560 ENOG41067MG lrgb family G9174_RS08565 ENOG4105VAW lrga family G9174_RS08570 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G9174_RS08580 ENOG4105TW1 Carbohydrate-selective porin OprB G9174_RS08595 ENOG4105CS2 ec 3.2.1.21 G9174_RS08605 ENOG4105KHU inner membrane protein YohD G9174_RS08610 ENOG41069YE inner membrane protein yohC G9174_RS08615 ENOG41061WM D-Alanyl-D-Alanine G9174_RS08625 ENOG4105CXG d-lactate dehydrogenase G9174_RS08630 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G9174_RS08635 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system G9174_RS08640 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component G9174_RS08645 ENOG4108IJ8 ABC transporter G9174_RS08650 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component G9174_RS08660 ENOG4108HRK Histidine kinase G9174_RS08665 ENOG4108NEV two component transcriptional regulator, LytTR family G9174_RS08670 ENOG4108W15 Protein of unknown function (DUF1456) G9174_RS08675 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G9174_RS08680 ENOG4105D1F ATP-binding protein G9174_RS08690 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly G9174_RS08695 ENOG4105EJC lysr family transcriptional regulator G9174_RS08700 ENOG4105C7N Xanthine uracil vitamin C permease G9174_RS08705 ENOG4105CPN adenine deaminase G9174_RS08710 ENOG4105DUM transcriptional regulator, lysR family G9174_RS08725 ENOG4105DWF phosphomethylpyrimidine kinase G9174_RS08730 ENOG4105EIE fructose-bisphosphate aldolase G9174_RS08735 ENOG4105IE8 Alpha-ketoglutarate permease G9174_RS08760 ENOG4105DEI Mannitol dehydrogenase G9174_RS08765 ENOG4105CMG Carbohydrate kinase G9174_RS08770 ENOG4105IE8 Alpha-ketoglutarate permease G9174_RS08775 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 G9174_RS08780 ENOG4105CXK mandelate racemase muconate lactonizing G9174_RS08785 ENOG4105DEF Extracellular solute-binding protein, family 5 G9174_RS08790 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G9174_RS08795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9174_RS08805 ENOG4108JQ7 (ABC) transporter G9174_RS08815 ENOG4105CFP Peptidase U32 G9174_RS08820 ENOG4105E3W Two component transcriptional regulator (Winged helix family G9174_RS08825 ENOG4105EB3 Histidine kinase G9174_RS08830 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9174_RS08835 ENOG4105BZS acriflavin resistance protein G9174_RS08840 ENOG4105BZS acriflavin resistance protein G9174_RS08845 ENOG4105ENT Efflux transporter rnd family, mfp subunit G9174_RS08850 ENOG4105CK2 sodium dicarboxylate symporter G9174_RS08870 ENOG4105BZU Histidine kinase G9174_RS08875 ENOG4105R8A Heat shock protein G9174_RS08880 ENOG4105D03 DNA-3-methyladenine glycosylase II G9174_RS08885 ENOG4105DBI uridine monophosphokinase G9174_RS08890 ENOG4105DHP deoxycytidine triphosphate deaminase G9174_RS08895 ENOG4108GAE asmA family G9174_RS08900 ENOG4105EE5 Membrane protein terC G9174_RS08905 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G9174_RS08910 ENOG4105MH5 phosphoesterase PA-phosphatase related protein G9174_RS08920 ENOG4108MRJ G9174_RS08925 ENOG4105DAY polysaccharide export protein G9174_RS08940 ENOG4105D3Q Sugar transferase G9174_RS08945 ENOG4108KBE Glycosyl transferase, family 2 G9174_RS08950 ENOG4108RT7 Glycosyl transferase, family 2 G9174_RS08975 ENOG4105PSV Polysaccharide Biosynthesis Protein G9174_RS08990 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G9174_RS08995 ENOG4105C1B dTDP-glucose 4-6-dehydratase G9174_RS09005 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G9174_RS09010 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase G9174_RS09055 ENOG4105CPK Glycosyl transferase (Group 1 G9174_RS09090 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G9174_RS09095 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G9174_RS09105 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G9174_RS09110 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G9174_RS09115 ENOG4105CIH Imidazole acetol-phosphate transaminase G9174_RS09125 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G9174_RS09135 ENOG4107SRH Nad-dependent epimerase dehydratase G9174_RS09140 ENOG4105EQ1 Transcriptional regulator G9174_RS09150 ENOG4105CUB amino acid G9174_RS09155 ENOG4105YVS arsR family transcriptional regulator G9174_RS09165 ENOG4105CJB Exodeoxyribonuclease I G9174_RS09170 ENOG4105DZ1 carboxypeptidase G9174_RS09180 ENOG4105DR8 Membrane G9174_RS09185 ENOG41090HJ UPF0265 protein G9174_RS09190 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G9174_RS09195 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G9174_RS09200 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G9174_RS09210 ENOG41090U3 tautomerase G9174_RS09215 ENOG4105HEI LysR family (Transcriptional regulator G9174_RS09220 ENOG4108KMH lipoate-protein ligase a G9174_RS09225 ENOG4105CSH Transporter G9174_RS09235 ENOG4105BZU Histidine kinase G9174_RS09245 ENOG4108YS1 cytoplasmic protein G9174_RS09250 ENOG4105YP6 Domain of unknown function (DUF1869) G9174_RS09255 ENOG4105ETT transcriptional Regulator, LysR family G9174_RS09270 ENOG4105BZU Histidine kinase G9174_RS09285 ENOG4105CVR type I restriction-modification system G9174_RS09350 ENOG4108PCE TRANSFER protein G9174_RS09380 ENOG4106D0Q Type IV secretion system protein VirB2 G9174_RS09425 ENOG4107ZSV Receptor G9174_RS09430 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G9174_RS09450 ENOG4105C0W non-ribosomal peptide synthetase G9174_RS09465 ENOG4105BZ1 (ABC) transporter G9174_RS09470 ENOG4105EYM Major Facilitator superfamily G9174_RS09490 ENOG4105UQX Mate efflux family protein G9174_RS09500 ENOG4105FYV Amp nucleosidase G9174_RS09520 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G9174_RS09525 ENOG4108WUH Transcriptional regulator, TetR family G9174_RS09530 ENOG4105EEQ Na H antiporter G9174_RS09545 ENOG4107R11 Transcriptional regulator G9174_RS09550 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G9174_RS09570 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) G9174_RS09580 ENOG4105FCK Membrane G9174_RS09585 ENOG4105Y0K Inner membrane protein YedR G9174_RS09590 ENOG4105EST Metal Dependent Phosphohydrolase G9174_RS09595 ENOG4105DVF Cytosine-specific methyltransferase G9174_RS09600 ENOG41090BB DNA mismatch endonuclease (vsr) G9174_RS09605 ENOG4105FDR Membrane G9174_RS09610 ENOG4105CKW Inner membrane protein yedI G9174_RS09620 ENOG4105YX3 cellular response to acidity G9174_RS09635 ENOG4105JCU Inherit from NOG: (Lipo)protein G9174_RS09640 ENOG4105E5K Alpha-amylase G9174_RS09645 ENOG4105EAB amino acid AbC transporter G9174_RS09650 ENOG4105K6H D-cysteine desulfhydrase G9174_RS09655 ENOG4105E5Q amino acid AbC transporter G9174_RS09660 ENOG4105CDA abc transporter atp-binding protein G9174_RS09665 ENOG4105VJY transcriptional regulator G9174_RS09670 ENOG4105XVG cytoplasmic protein G9174_RS09675 ENOG4105WH1 Two component transcriptional regulator luxr family G9174_RS09710 ENOG4106RHG Yeca family G9174_RS09715 ENOG4105E0U tyrosine-specific transport protein G9174_RS09720 ENOG4105VVZ metal-binding protein G9174_RS09725 ENOG41090A1 ferritin G9174_RS09740 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9174_RS09745 ENOG4105N4N Protein of unknown function (DUF2766) G9174_RS09760 ENOG4108UEC Ferritin-like protein G9174_RS09770 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator G9174_RS09780 ENOG4105CNN ABC, transporter G9174_RS09790 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G9174_RS09795 ENOG4108VA4 Universal stress protein G9174_RS09800 ENOG4105CT4 transporter G9174_RS09805 ENOG4105F5H Glycosyl Hydrolase Family 88 G9174_RS09810 ENOG4105C75 arginyL-tRNA synthetase G9174_RS09815 ENOG4106ZCM YecM protein G9174_RS09820 ENOG4106N3A copper homeostasis protein cutc G9174_RS09825 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) G9174_RS09830 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) G9174_RS09835 ENOG4105WJG Glutathione G9174_RS09840 ENOG41081XQ Conserved Protein G9174_RS09845 ENOG4105D3W isochorismatase G9174_RS09850 ENOG4105C9M aspartyl-trna synthetase G9174_RS09855 ENOG4108TIT dATP pyrophosphohydrolase G9174_RS09860 ENOG4105CDY transcriptional regulatory protein G9174_RS09865 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) G9174_RS09870 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G9174_RS09875 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G9174_RS09880 ENOG4105FAV ABC, transporter G9174_RS09890 ENOG4105NXV High-affinity zinc uptake system protein G9174_RS09895 ENOG4105DR5 peptidase G9174_RS09900 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase G9174_RS09905 ENOG4105CA9 Pyruvate kinase G9174_RS09910 ENOG4106KNT transcriptional regulator G9174_RS09920 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G9174_RS09925 ENOG4105C01 Dihydroxy-acid dehydratase G9174_RS09930 ENOG4108UHU Aldolase G9174_RS09940 ENOG4105X2V dna damage-inducible protein G9174_RS09945 ENOG4108Q2J Inner membrane protein YebE G9174_RS09950 ENOG4105CUG Oligopeptidase b G9174_RS09955 ENOG4105UMD exodeoxyribonuclease X G9174_RS09960 ENOG4105MPK DNA polymerase III subunit theta G9174_RS09965 ENOG4105FXM Copper resistance protein G9174_RS09970 ENOG4108PNC copper resistance G9174_RS09975 ENOG4105NKT exported protein G9174_RS09985 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 G9174_RS10010 ENOG4108MJ5 VirK protein G9174_RS10015 ENOG4108R1E Serine threonine protein phosphatase 1 G9174_RS10020 ENOG4105UVW uncharacterized protein yebW G9174_RS10025 ENOG4105WT8 Protein of unknown function (DUF1480) G9174_RS10030 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G9174_RS10035 ENOG4105DY2 Paraquat-inducible protein b G9174_RS10040 ENOG4105H2K paraquat-inducible protein a G9174_RS10045 ENOG4108ZGC gaf domain protein G9174_RS10050 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) G9174_RS10055 ENOG4105CN1 protease G9174_RS10060 ENOG4105D0M Protease HtpX homolog G9174_RS10065 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9174_RS10070 ENOG4105J4Q Transcriptional regulator G9174_RS10075 ENOG4105TIK G9174_RS10085 ENOG4105Q3Y exported protein G9174_RS10100 ENOG4105CJN penicillin-binding protein G9174_RS10105 ENOG4105DHI Methyltransferase G9174_RS10110 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) G9174_RS10115 ENOG4108NK4 UPF0266 membrane protein G9174_RS10120 ENOG4105F3R pts system mannose fructose sorbose family iid G9174_RS10125 ENOG4105ETZ PTS System G9174_RS10130 ENOG4105DAS pts system G9174_RS10135 ENOG4105EE5 Membrane protein terC G9174_RS10140 ENOG4107XTP (EAL) domain protein G9174_RS10145 ENOG4105EJQ L-serine dehydratase G9174_RS10150 ENOG4105P8F nudix hydrolase G9174_RS10160 ENOG4105X5C UPF0181 protein G9174_RS10165 ENOG4105M4H endoribonuclease L-psp G9174_RS10170 ENOG4105DVT helicase G9174_RS10175 ENOG41072GX Peptidase M22 Glycoprotease G9174_RS10180 ENOG4105Y4Z Outer Membrane Lipoprotein G9174_RS10185 ENOG4105CEY Amp-dependent synthetase and ligase G9174_RS10190 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) G9174_RS10195 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) G9174_RS10200 ENOG4107QMS site-determining protein G9174_RS10205 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G9174_RS10210 ENOG4105VNG YcgL domain-containing protein G9174_RS10215 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G9174_RS10220 ENOG4108ZZ3 UPF0260 protein G9174_RS10230 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) G9174_RS10235 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G9174_RS10240 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) G9174_RS10245 ENOG4105ED1 spovr family G9174_RS10255 ENOG4105MWK D-amino acid dehydrogenase, small subunit G9174_RS10265 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) G9174_RS10270 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G9174_RS10275 ENOG4106JQ5 Transglycosylase SLT domain G9174_RS10280 ENOG4105E0K tonB-dependent siderophore receptor G9174_RS10290 ENOG4105CT4 transporter G9174_RS10340 ENOG410811B TRANSCRIPTIONal G9174_RS10345 ENOG4105C7B Threonine dehydratase G9174_RS10350 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) G9174_RS10360 ENOG4105C6N Formate acetyltransferase G9174_RS10375 ENOG4105C32 Amino acid ABC transporter (Permease) G9174_RS10380 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G9174_RS10385 ENOG4105C0Z ABC transporter G9174_RS10390 ENOG4108IV0 ABC, transporter G9174_RS10395 ENOG4107YNJ LysR family Transcriptional regulator G9174_RS10415 ENOG4105CSH Transporter G9174_RS10425 ENOG4105F04 LysR family Transcriptional regulator G9174_RS10435 ENOG4105D3G Pseudouridine synthase G9174_RS10440 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme G9174_RS10460 ENOG4108ZG0 Ompa motb domain protein G9174_RS10470 ENOG4105CS6 Rhs element vgr protein G9174_RS10525 ENOG4105E6M Sulphatase-modifying factor protein G9174_RS10615 ENOG4105C3G gtp-binding protein G9174_RS10620 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G9174_RS10625 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria G9174_RS10635 ENOG4105CHH sulfate transporter G9174_RS10640 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G9174_RS10645 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G9174_RS10655 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G9174_RS10660 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G9174_RS10665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G9174_RS10670 ENOG4108YY7 Invasion gene expression up-regulator SirB G9174_RS10675 ENOG41063JG Transcriptional regulator G9174_RS10680 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G9174_RS10685 ENOG4105EWV Sodium calcium exchanger membrane region G9174_RS10690 ENOG4105WS7 Cation transport regulator G9174_RS10695 ENOG4108NH8 Cation transport protein G9174_RS10705 ENOG41090EX DsrE family G9174_RS10715 ENOG4105I5W Transporter G9174_RS10725 ENOG4105D7T ABC transporter G9174_RS10730 ENOG4107QZF nitrite reductase NADPH large subunit G9174_RS10740 ENOG4105ID0 Putative invasin G9174_RS10745 ENOG4105WH1 Two component transcriptional regulator luxr family G9174_RS10750 ENOG4105BZU Histidine kinase G9174_RS10755 ENOG4105DQQ Major facilitator superfamily MFS_1 G9174_RS10765 ENOG4105CRU nitrate reductase, alpha subunit G9174_RS10770 ENOG4108IUE nitrate reductase beta subunit G9174_RS10775 ENOG4105R3A Nitrate reductase G9174_RS10780 ENOG41076YT nitrate reductase, gamma subunit G9174_RS10825 ENOG4105CIY formyltetrahydrofolate deformylase G9174_RS10835 ENOG4105D78 K07001 NTE family protein G9174_RS10840 ENOG4105I93 response regulator G9174_RS10845 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G9174_RS10860 ENOG4107104 thymidine kinase G9174_RS10865 ENOG4105C0A alcohol dehydrogenase G9174_RS10875 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G9174_RS10880 ENOG4108J59 Extracellular solute-binding protein, family 5 G9174_RS10885 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G9174_RS10890 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9174_RS10895 ENOG4105C3U ABC transporter G9174_RS10900 ENOG4108JQ7 (ABC) transporter G9174_RS10905 ENOG4105EYW Ion transport protein G9174_RS10910 ENOG4108W5H UPF0263 protein G9174_RS10915 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G9174_RS10925 ENOG4108YYC ycei family G9174_RS10935 ENOG4105K9H YciI-like protein G9174_RS10940 ENOG410822N TonB family G9174_RS10950 ENOG4105P10 Uncharacterized protein ydiZ G9174_RS10955 ENOG4105DE4 1-phosphofructokinase G9174_RS10960 ENOG4108NE3 Salt-induced outer membrane protein G9174_RS10975 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G9174_RS10980 ENOG41082NX 50s ribosomal protein l35 G9174_RS10995 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G9174_RS11000 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G9174_RS11005 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G9174_RS11015 ENOG4105MWK D-amino acid dehydrogenase, small subunit G9174_RS11020 ENOG4105RQF LysR family Transcriptional regulator G9174_RS11030 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) G9174_RS11035 ENOG4105D01 (LipO)protein G9174_RS11040 ENOG4108V06 Glutathione peroxidase G9174_RS11050 ENOG4108QBX (LipO)protein G9174_RS11055 ENOG4105CNG UPF0061 protein G9174_RS11065 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G9174_RS11080 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G9174_RS11090 ENOG4105IPI Membrane G9174_RS11095 ENOG4105CQB FAD linked oxidase domain protein G9174_RS11100 ENOG4105KA0 thioesterase Superfamily protein G9174_RS11105 ENOG4105Y3U Transglycosylase-associated protein G9174_RS11120 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G9174_RS11130 ENOG4105E0A ABC, transporter G9174_RS11135 ENOG4105EHG Permease protein G9174_RS11145 ENOG4106KR7 LysR family Transcriptional regulator G9174_RS11170 ENOG4105DMF Dehydrogenase G9174_RS11175 ENOG4105KBX Transcriptional regulator, TetR family G9174_RS11195 ENOG4108Z4V iron-sulfur cluster assembly G9174_RS11200 ENOG4105DIW FeS assembly protein SUFB G9174_RS11205 ENOG4105C3K feS assembly ATPase SufC G9174_RS11210 ENOG4105JRK feS assembly protein SufD G9174_RS11215 ENOG4105C9B Cysteine desulfurase G9174_RS11220 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) G9174_RS11225 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G9174_RS11235 ENOG4105CA9 Pyruvate kinase G9174_RS11250 ENOG4105RFR Protein of unknown function (DUF2767) G9174_RS11265 ENOG4105DJB Major Facilitator Superfamily G9174_RS11270 ENOG4105E2X shikimate dehydrogenase G9174_RS11275 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein G9174_RS11280 ENOG4108W0P ABC transporter G9174_RS11285 ENOG4105EHG Permease protein G9174_RS11290 ENOG4105S10 periplasmic binding protein G9174_RS11295 ENOG4108K2P TRANSCRIPTIONal G9174_RS11300 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G9174_RS11310 ENOG4107UB2 Alpha beta hydrolase fold G9174_RS11315 ENOG4105IKQ hydratase G9174_RS11325 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G9174_RS11330 ENOG4108SC4 )-transporter G9174_RS11345 ENOG4108T2C cysteine dioxygenase type I G9174_RS11350 ENOG4105CR8 Transcriptional regulator G9174_RS11355 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G9174_RS11375 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G9174_RS11380 ENOG4108IY8 ABC, transporter G9174_RS11390 ENOG4105E0A ABC, transporter G9174_RS11395 ENOG4105DQ5 transport system permease protein G9174_RS11415 ENOG4106PMH Extracellular solute-binding protein family 3 G9174_RS11420 ENOG4105E5Q amino acid AbC transporter G9174_RS11425 ENOG4105CDA abc transporter atp-binding protein G9174_RS11430 ENOG4105KZM cytoplasmic protein G9174_RS11440 ENOG41083G8 Multidrug resistance protein MdtM G9174_RS11465 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G9174_RS11470 ENOG4105DG4 malate L-lactate dehydrogenase G9174_RS11475 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC G9174_RS11480 ENOG4107Z33 ABC transporter, permease G9174_RS11510 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) G9174_RS11515 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) G9174_RS11520 ENOG41060IM Heme exporter protein G9174_RS11530 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) G9174_RS11535 ENOG4105DA4 cytochrome c-type biogenesis protein G9174_RS11540 ENOG4107QX9 Thiol disulfide interChange protein G9174_RS11545 ENOG4105KWW Biogenesis protein G9174_RS11550 ENOG4108M1T Cytochrome c-type biogenesis protein G9174_RS11565 ENOG410822N TonB family G9174_RS11580 ENOG41062D9 Histidine kinase G9174_RS11585 ENOG4105E3W Two component transcriptional regulator (Winged helix family G9174_RS11600 ENOG4105BZS acriflavin resistance protein G9174_RS11615 ENOG4105CHR reductase G9174_RS11620 ENOG4105C7K acetolactate synthase G9174_RS11635 ENOG4105DTD Dehydrogenase G9174_RS11640 ENOG4105CY2 Citrate transporter G9174_RS11645 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G9174_RS11655 ENOG4107QNJ CoA-transferase subunit B G9174_RS11665 ENOG4106NZI LysR family Transcriptional regulator G9174_RS11690 ENOG4105CQB FAD linked oxidase domain protein G9174_RS11695 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G9174_RS11715 ENOG4105KME endoribonuclease L-psp G9174_RS11720 ENOG4107TTD cytosine deaminase G9174_RS11730 ENOG4105EMY transcriptional regulator G9174_RS11790 ENOG4108JQ7 (ABC) transporter G9174_RS11795 ENOG4105C3U ABC transporter G9174_RS11820 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase G9174_RS11825 ENOG4105E98 transcriptional regulator DeoR family G9174_RS11835 ENOG4107B2H carbonic anhydrase G9174_RS11860 ENOG4105CY0 Metallo-Beta-Lactamase G9174_RS11895 ENOG4108URH decarboxylase G9174_RS11905 ENOG4107QI1 Mate efflux family protein G9174_RS11910 ENOG4108R6K riboflavin synthase, subunit alpha G9174_RS11915 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G9174_RS11920 ENOG4105CZQ inner membrane transport protein YdhC G9174_RS11925 ENOG4105F52 Transcriptional regulator G9174_RS11930 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS11940 ENOG4105F27 Major Facilitator G9174_RS11945 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G9174_RS11955 ENOG4105K4H Nlp p60 protein G9174_RS11960 ENOG4105M2J Glutaredoxin G9174_RS11965 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) G9174_RS11970 ENOG4108UYE Lactoylglutathione lyase G9174_RS11975 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G9174_RS11980 ENOG4108WUH Transcriptional regulator, TetR family G9174_RS11985 ENOG4105XZD Fe-S protein G9174_RS11990 ENOG4107RGM aldo keto reductase G9174_RS11995 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G9174_RS12000 ENOG4105DSW Fusaric acid resistance protein G9174_RS12005 ENOG4105Y49 secretion protein, HlyD family G9174_RS12020 ENOG4105BZU Histidine kinase G9174_RS12025 ENOG4108XTF Outer Membrane Lipoprotein G9174_RS12030 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G9174_RS12035 ENOG410642K Lysozyme inhibitor G9174_RS12040 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G9174_RS12045 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G9174_RS12050 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) G9174_RS12055 ENOG4108K3A Glutathione S-transferase G9174_RS12065 ENOG4105CSM endonuclease III G9174_RS12075 ENOG4108UQQ Electron transport complex G9174_RS12100 ENOG4105M9B inner membrane protein ydgK G9174_RS12110 ENOG4105CS2 ec 3.2.1.21 G9174_RS12120 ENOG4105D9R oxidoreductase G9174_RS12125 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G9174_RS12130 ENOG4105EQ0 Major Facilitator superfamily G9174_RS12150 ENOG4105CPW cytochrome b561 G9174_RS12170 ENOG4105DDW LysR family Transcriptional regulator G9174_RS12175 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha G9174_RS12180 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta G9174_RS12185 ENOG4105E32 cytoplasmic protein G9174_RS12190 ENOG4105EBR Carboxylesterase G9174_RS12205 ENOG4108Z9I -acetyltransferase G9174_RS12210 ENOG4107WE3 acetyltransferase YdcK G9174_RS12215 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein G9174_RS12220 ENOG41088CC tellurite resistance protein tehB G9174_RS12225 ENOG4108KKZ (LipO)protein G9174_RS12235 ENOG4105UEI Transcriptional Regulator AraC Family G9174_RS12240 ENOG4105DKK Benzoate G9174_RS12245 ENOG4108JCI Transcriptional regulator G9174_RS12255 ENOG4105CFP Peptidase U32 G9174_RS12275 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G9174_RS12280 ENOG4105C4M (Ubiquinol oxidase) subunit I G9174_RS12285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9174_RS12290 ENOG4107TYH extracellular solute-binding protein family 1 G9174_RS12295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9174_RS12300 ENOG4105D81 ABC transporter, permease G9174_RS12305 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component G9174_RS12310 ENOG4105C26 Dehydrogenase G9174_RS12340 ENOG410654E Membrane G9174_RS12345 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 G9174_RS12355 ENOG4105DEF Extracellular solute-binding protein, family 5 G9174_RS12360 ENOG4105R71 cytoplasmic protein G9174_RS12365 ENOG4108T9Y Inner membrane protein ydcZ G9174_RS12370 ENOG4108Z7F N-acetyltransferase G9174_RS12380 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G9174_RS12385 ENOG4105DU0 nucleoside hydrolase G9174_RS12395 ENOG41065TG regulatoR G9174_RS12400 ENOG4105CI2 imidazolone-5-propionate hydrolase G9174_RS12405 ENOG4105CHB tonB-dependent Receptor G9174_RS12410 ENOG4108NS2 receptor G9174_RS12420 ENOG4105C85 amino acid G9174_RS12450 ENOG4105EAB amino acid AbC transporter G9174_RS12460 ENOG4105DRP amino acid AbC transporter G9174_RS12465 ENOG4105CDA abc transporter atp-binding protein G9174_RS12475 ENOG4108N27 Glutathione S-transferase G9174_RS12510 ENOG4108MEJ flavin reductase domain protein G9174_RS12515 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9174_RS12520 ENOG4105C4Y ABC transporter G9174_RS12525 ENOG4107RCV ABC transporter, permease G9174_RS12530 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G9174_RS12535 ENOG4105D0D Nitrate reductase 2, gamma subunit G9174_RS12540 ENOG4108NZN Respiratory nitrate reductase 2 delta chain G9174_RS12545 ENOG4108IUE nitrate reductase beta subunit G9174_RS12550 ENOG4105CRU nitrate reductase, alpha subunit G9174_RS12555 ENOG4107QND Nitrite extrusion protein G9174_RS12570 ENOG4107HP6 Transcriptional regulator G9174_RS12575 ENOG4105DTQ mandelate racemase muconate lactonizing G9174_RS12580 ENOG4105NN7 muconolactone delta-isomerase G9174_RS12585 ENOG410626B catechol 1,2-dioxygenase G9174_RS12595 ENOG4108UKV benzoate 1,2-dioxygenase G9174_RS12620 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G9174_RS12625 ENOG4108MG3 formate dehydrogenase G9174_RS12640 ENOG4105CSR polyphosphate kinase 2 G9174_RS12650 ENOG4105F27 Major Facilitator G9174_RS12665 ENOG4108JQ6 ABC transporter G9174_RS12670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9174_RS12685 ENOG4105DQ4 alcohol dehydrogenase G9174_RS12700 ENOG4105C5H ABC transporter G9174_RS12715 ENOG4107R1I NAD-dependent malic enzyme G9174_RS12735 ENOG4105EQ2 LysR family Transcriptional regulator G9174_RS12740 ENOG4105N0E Protein of unknown function (DUF2543) G9174_RS12745 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G9174_RS12760 ENOG4108N8X transition metal ion binding G9174_RS12770 ENOG4105CG3 alpha amylase, catalytic region G9174_RS12790 ENOG4108YDI single-species biofilm formation on inanimate substrate G9174_RS12800 ENOG4108Z9K Osmotically inducible protein G9174_RS12825 ENOG4105FFC UPF0187 protein G9174_RS12830 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit G9174_RS12835 ENOG4105C5Q Transcriptional regulator G9174_RS12840 ENOG4105CK1 PTS System G9174_RS12865 ENOG4105VZJ PTS System G9174_RS12870 ENOG4105VCP PTS System G9174_RS12875 ENOG4108KUU Inner membrane metabolite transport protein ydjE G9174_RS12880 ENOG4105KT7 mgtC SapB transporter G9174_RS12885 ENOG4105D6Z AFG1 family ATPase G9174_RS12890 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) G9174_RS12895 ENOG4106KR7 LysR family Transcriptional regulator G9174_RS12915 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G9174_RS12920 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF G9174_RS12925 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E G9174_RS12935 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) G9174_RS12940 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) G9174_RS12950 ENOG4108IGT Dipeptidase G9174_RS12955 ENOG4108J2P Alpha beta hydrolase fold G9174_RS12965 ENOG4105E0F Histidine kinase G9174_RS12980 ENOG4105DY8 decarboxylase G9174_RS12985 ENOG4108JPW Aminotransferase G9174_RS12990 ENOG4107Z6I Thiamine biosynthesis protein G9174_RS12995 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component G9174_RS13000 ENOG4108YI8 ABC transporter G9174_RS13005 ENOG4105ETU transcriptional activator (TenA G9174_RS13020 ENOG4105CIB oxidoreductase Domain protein G9174_RS13030 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS13035 ENOG4105BZU Histidine kinase G9174_RS13040 ENOG4107QUY Guanine deaminase G9174_RS13045 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G9174_RS13085 ENOG4105CVJ phosphoglycerate mutase G9174_RS13090 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G9174_RS13100 ENOG41089BK Glutamine amido-transferase G9174_RS13120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G9174_RS13145 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G9174_RS13170 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G9174_RS13190 ENOG4105E5Q amino acid AbC transporter G9174_RS13200 ENOG4105C5R Aminotransferase G9174_RS13215 ENOG4105CBN LysR family transcriptional regulator G9174_RS13225 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G9174_RS13230 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain G9174_RS13235 ENOG4105CSH Transporter G9174_RS13265 ENOG4105FCD Major Facilitator G9174_RS13275 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS13280 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia G9174_RS13290 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC G9174_RS13295 ENOG4105UP7 3-epimerase G9174_RS13305 ENOG4108YRF PTS System G9174_RS13310 ENOG4105DM4 PTS System G9174_RS13315 ENOG410829K Lysine exporter protein (Lyse ygga) G9174_RS13325 ENOG4105CBN LysR family transcriptional regulator G9174_RS13330 ENOG4105HEI LysR family (Transcriptional regulator G9174_RS13345 ENOG4107PP3 Acetylornithine deacetylase G9174_RS13360 ENOG4105CNN ABC, transporter G9174_RS13365 ENOG4105C2J ABC transporter G9174_RS13370 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS13400 ENOG4109066 lysm domain bon superfamily protein G9174_RS13415 ENOG4105CNW domain protein G9174_RS13425 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC G9174_RS13435 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta G9174_RS13440 ENOG4105RHY Pfam:UPF0157 G9174_RS13445 ENOG4105EQ2 LysR family Transcriptional regulator G9174_RS13450 ENOG4105CPC Aldo Keto reductase G9174_RS13455 ENOG4107SET aldo keto reductase G9174_RS13465 ENOG4105CPC Aldo Keto reductase G9174_RS13520 ENOG4105MVE transcriptional regulator G9174_RS13525 ENOG4105CMG Carbohydrate kinase G9174_RS13530 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G9174_RS13535 ENOG4105E98 transcriptional regulator DeoR family G9174_RS13540 ENOG4105UP7 3-epimerase G9174_RS13545 ENOG4108RVA ribokinase G9174_RS13550 ENOG4105EDR glucose galactose transporter G9174_RS13565 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G9174_RS13570 ENOG4105CHR reductase G9174_RS13575 ENOG4105CHU acetyl-coa acetyltransferase G9174_RS13595 ENOG4105BZW Glycerate kinase G9174_RS13600 ENOG4107VHA regulatoR G9174_RS13610 ENOG4105JQN Transcriptional regulator G9174_RS13620 ENOG4107YCY Transcriptional regulator G9174_RS13625 ENOG4105CI1 PTS System G9174_RS13630 ENOG4105F8D glycoside hydrolase family 4 G9174_RS13635 ENOG4105C54 Major Facilitator superfamily G9174_RS13640 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein G9174_RS13655 ENOG4105NIV Esterase G9174_RS13660 ENOG4105BZU Histidine kinase G9174_RS13675 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G9174_RS13690 ENOG4108VCD Chaperone G9174_RS13695 ENOG4105CW0 outer membrane usher protein G9174_RS13705 ENOG4105F32 YngK protein G9174_RS13710 ENOG4105CAF HipA N-terminal domain protein G9174_RS13715 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein G9174_RS13720 ENOG4105VT2 5-hydroxyisourate hydrolase G9174_RS13725 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) G9174_RS13730 ENOG4105C2W permease G9174_RS13735 ENOG41061H0 Monooxygenase G9174_RS13740 ENOG4108KSA LysR family transcriptional regulator G9174_RS13760 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions G9174_RS13775 ENOG4105VYA Uncharacterized conserved protein (DUF2132) G9174_RS13785 ENOG4105D01 (LipO)protein G9174_RS13795 ENOG4108UMI ABC transporter, permease G9174_RS13800 ENOG4105EA8 2-Nitropropane dioxygenase G9174_RS13805 ENOG4105EGI Transcriptional regulator G9174_RS13810 ENOG4105CBP Major Facilitator G9174_RS13820 ENOG4105F9N Major Facilitator Superfamily G9174_RS13870 ENOG4107QZW Altronate oxidoreductase G9174_RS13880 ENOG4105BZU Histidine kinase G9174_RS13885 ENOG4105M0C cytoplasmic protein G9174_RS13890 ENOG4105CSV Glutaminase G9174_RS13895 ENOG4105C26 Dehydrogenase G9174_RS13900 ENOG4105EGI Transcriptional regulator G9174_RS13910 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G9174_RS13915 ENOG4105MVE transcriptional regulator G9174_RS13920 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G9174_RS13925 ENOG4107S2N Type III effector Hrp-dependent G9174_RS13930 ENOG4105C0A alcohol dehydrogenase G9174_RS13935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G9174_RS13950 ENOG4108R66 Conserved Protein G9174_RS13955 ENOG4105CHR reductase G9174_RS13960 ENOG4105JAB phenazine biosynthesis protein, phzf family G9174_RS13965 ENOG4105F27 Major Facilitator G9174_RS13970 ENOG41082NP Multiple antibiotic resistance G9174_RS13980 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G9174_RS13985 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF G9174_RS13990 ENOG4106DNR multiple antibiotic resistance protein G9174_RS13995 ENOG4108594 Permease of the drug metabolite transporter G9174_RS14000 ENOG4105E5W Transporter G9174_RS14010 ENOG4108IV0 ABC, transporter G9174_RS14015 ENOG4105C0Z ABC transporter G9174_RS14020 ENOG4105CNN ABC, transporter G9174_RS14025 ENOG4105C32 Amino acid ABC transporter (Permease) G9174_RS14030 ENOG41083Z3 extracellular ligand-binding receptor G9174_RS14045 ENOG4105ECQ AraC Family Transcriptional Regulator G9174_RS14060 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS14065 ENOG4105CNT hydrolase family 2 G9174_RS14070 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G9174_RS14075 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G9174_RS14085 ENOG4108J4B Beta-lactamase G9174_RS14090 ENOG4105MVE transcriptional regulator G9174_RS14100 ENOG4105G63 Type III effector Hrp-dependent G9174_RS14105 ENOG4105FB2 class II Aldolase G9174_RS14110 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G9174_RS14115 ENOG4105C6Z Gluconate G9174_RS14135 ENOG4105BZU Histidine kinase G9174_RS14140 ENOG4108WTK competence damage-inducible protein G9174_RS14145 ENOG4108ZNX Heat shock protein G9174_RS14160 ENOG4108WQH regulatoR G9174_RS14175 ENOG4108RAV Conserved protein G9174_RS14180 ENOG4105R1U AraC Family Transcriptional Regulator G9174_RS14190 ENOG4105DGW oligopeptidase A G9174_RS14195 ENOG4105EMU Dehydrogenase G9174_RS14200 ENOG4107XBN GntR Family Transcriptional Regulator G9174_RS14205 ENOG4108U51 Universal stress protein G9174_RS14210 ENOG4105DEI Mannitol dehydrogenase G9174_RS14215 ENOG4108I5G Major Facilitator superfamily G9174_RS14220 ENOG4105KK4 UPF0060 membrane protein G9174_RS14225 ENOG4105M5Q UPF0482 protein G9174_RS14230 ENOG4108MK9 spermidine N(1)-acetyltransferase G9174_RS14240 ENOG4105KBG Protein of unknown function (DUF1161) G9174_RS14245 ENOG4107QY8 reductase G9174_RS14250 ENOG4105QAX Iron-sulfur G9174_RS14255 ENOG4107KGK dmso reductase anchor subunit G9174_RS14260 ENOG4108NEM leader-binding protein dmsD G9174_RS14265 ENOG4105CMQ Chloride channel G9174_RS14270 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G9174_RS14275 ENOG4105DAG ROK family G9174_RS14280 ENOG4106NZI LysR family Transcriptional regulator G9174_RS14285 ENOG4105D94 Major Facilitator Superfamily G9174_RS14290 ENOG4105CTD carboxy-peptidase G9174_RS14300 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap G9174_RS14310 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) G9174_RS14315 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) G9174_RS14320 ENOG4105DSF transport protein G9174_RS14350 ENOG4107TT2 Auxin Efflux Carrier G9174_RS14355 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase G9174_RS14360 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G9174_RS14365 ENOG4108K70 Transcriptional regulator G9174_RS14370 ENOG4105DWT malate dehydrogenase (quinone) G9174_RS14375 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G9174_RS14385 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G9174_RS14390 ENOG4108MRH transcriptional regulatory protein G9174_RS14410 ENOG4107GFK fumarate G9174_RS14420 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G9174_RS14425 ENOG4105F2Z 3-oxoadipate enol-lactonase G9174_RS14430 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G9174_RS14435 ENOG4105CHU acetyl-coa acetyltransferase G9174_RS14440 ENOG4107QNJ CoA-transferase subunit B G9174_RS14450 ENOG4107HP6 Transcriptional regulator G9174_RS14455 ENOG4108DG9 Smr protein MutS2 G9174_RS14460 ENOG4106KR7 LysR family Transcriptional regulator G9174_RS14470 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B G9174_RS14475 ENOG4105CFC Transporter G9174_RS14485 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G9174_RS14490 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G9174_RS14495 ENOG4105Q9Y Universal stress protein G9174_RS14500 ENOG410671Z uncharacterized protein ydiH G9174_RS14505 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G9174_RS14510 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G9174_RS14520 ENOG4105C5D exported protein G9174_RS14525 ENOG4105D5Q Arginine ornithine antiporter G9174_RS14530 ENOG410642E Short chain dehydrogenase G9174_RS14535 ENOG4105RA2 Membrane G9174_RS14540 ENOG4107EXC regulatoR G9174_RS14550 ENOG4105JJR Histidine kinase G9174_RS14560 ENOG4105C9Q fumarate hydratase class II G9174_RS14570 ENOG4107GFK fumarate G9174_RS14575 ENOG4105EIP mannose-6-phosphate isomerase G9174_RS14580 ENOG4106J39 exported protein G9174_RS14585 ENOG4107P2S Transcriptional regulator G9174_RS14590 ENOG4105CI1 PTS System G9174_RS14595 ENOG4105C87 Aminotransferase class I and II G9174_RS14605 ENOG41061EV selenium-binding protein YdfZ G9174_RS14620 ENOG41066VF YeeE YedE family protein G9174_RS14630 ENOG41064WM Uncharacterized protein YcgX G9174_RS14635 ENOG4105VPI YqaE family transport protein G9174_RS14640 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G9174_RS14645 ENOG4105C26 Dehydrogenase G9174_RS14655 ENOG4107DB1 DUF218 domain G9174_RS14660 ENOG4105CSH Transporter G9174_RS14670 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) G9174_RS14675 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) G9174_RS14680 ENOG4105C26 Dehydrogenase G9174_RS14685 ENOG4105F4X arginine G9174_RS14690 ENOG4105C8Y Acetylornithine aminotransferase G9174_RS14700 ENOG4105D82 Glutamate dehydrogenase G9174_RS14705 ENOG4108FN7 Aldo keto reductase G9174_RS14710 ENOG410642W LysR family Transcriptional regulator G9174_RS14730 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G9174_RS14740 ENOG4105CQ7 ATP-dependent helicase G9174_RS14745 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G9174_RS14755 ENOG4108Z0R Transferase G9174_RS14760 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein G9174_RS14765 ENOG4105DZS Phenylacetate-CoA ligase G9174_RS14770 ENOG4105CHU acetyl-coa acetyltransferase G9174_RS14775 ENOG4108ZJI phenylacetic acid degradation protein G9174_RS14780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G9174_RS14785 ENOG4108UKI Enoyl-CoA hydratase G9174_RS14790 ENOG4105E39 Enoyl-CoA hydratase G9174_RS14795 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9174_RS14800 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G9174_RS14805 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G9174_RS14810 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G9174_RS14815 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G9174_RS14820 ENOG4105DXM phenylacetic acid degradation protein G9174_RS14825 ENOG4105F11 amine oxidase G9174_RS14840 ENOG4105C26 Dehydrogenase G9174_RS14845 ENOG4108WFR AraC Family Transcriptional Regulator G9174_RS14850 ENOG4105WXT Conserved Protein G9174_RS14855 ENOG410689M (LipO)protein G9174_RS14860 ENOG4107H52 Dicarboxylate transport G9174_RS14865 ENOG4108KF1 Membrane G9174_RS14870 ENOG4105C5I Dehydrogenase G9174_RS14875 ENOG41090X5 Heat shock protein hslJ G9174_RS14880 ENOG4105IKK cytoplasmic protein G9174_RS14885 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) G9174_RS14890 ENOG4105FCK Membrane G9174_RS14900 ENOG4108RW8 Universal stress protein F G9174_RS14910 ENOG4105C1J atp-dependent rna helicase G9174_RS14915 ENOG4107RX3 Mg2 transporter protein cora family protein G9174_RS14920 ENOG4105E98 transcriptional regulator DeoR family G9174_RS14925 ENOG4105D9R oxidoreductase G9174_RS14940 ENOG4105C85 amino acid G9174_RS14945 ENOG4105F7P transcriptional regulator AsnC family G9174_RS14955 ENOG4105CGF Aromatic amino acid aminotransferase G9174_RS14960 ENOG4108UMI ABC transporter, permease G9174_RS14970 ENOG4105D01 (LipO)protein G9174_RS15010 ENOG4105HEI LysR family (Transcriptional regulator G9174_RS15035 ENOG4108XFH Transcriptional regulator G9174_RS15040 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G9174_RS15125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G9174_RS15135 ENOG4108ZG0 Ompa motb domain protein G9174_RS15160 ENOG4106FE3 DNA repair G9174_RS15170 ENOG4105EKQ RNA-directed DNA polymerase G9174_RS15255 ENOG4105E4C Lytic transglycosylase catalytic G9174_RS15325 ENOG4107ZQ5 Phage-associated protein, HI1409 family G9174_RS15330 ENOG4108N0N Phage Terminase Large Subunit G9174_RS15360 ENOG4105HGD Antitermination protein G9174_RS15465 ENOG4105DFP Integrase G9174_RS15470 ENOG4108Z0Z intracellular protease Pfpi family G9174_RS15485 ENOG4105CBN LysR family transcriptional regulator G9174_RS15510 ENOG4107RTG Major Facilitator superfamily G9174_RS15515 ENOG4105ENX hydrolase G9174_RS15520 ENOG4105EQ2 LysR family Transcriptional regulator G9174_RS15535 ENOG4107QSI ABC, transporter G9174_RS15545 ENOG4105KXI murein peptide amidase A G9174_RS15550 ENOG4107S8C mandelate racemase muconate lactonizing G9174_RS15555 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) G9174_RS15560 ENOG4108KK1 membrane protein AbrB duplication G9174_RS15565 ENOG4108JU8 Transcriptional regulator G9174_RS15570 ENOG4105F8D glycoside hydrolase family 4 G9174_RS15575 ENOG4105W8I Transcriptional regulator G9174_RS15580 ENOG4106K28 UPF0283 membrane protein G9174_RS15585 ENOG4105CM6 amino acid regulated cytosolic protein G9174_RS15590 ENOG4105NNG Peripheral inner membrane phage-shock protein G9174_RS15595 ENOG4105FM1 phage shock protein C G9174_RS15600 ENOG4105YYT phage shock protein B G9174_RS15605 ENOG41087YS Phage shock protein A G9174_RS15610 ENOG4105E51 psp operon transcriptional activator G9174_RS15620 ENOG4105CH2 amidohydrolase G9174_RS15625 ENOG41063ZK Transcriptional Regulator AraC Family G9174_RS15645 ENOG4108EKA peptide transport system, permease G9174_RS15650 ENOG4108RAV Conserved protein G9174_RS15660 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G9174_RS15665 ENOG4105KT5 UmuD protein G9174_RS15670 ENOG4105EKQ RNA-directed DNA polymerase G9174_RS15680 ENOG4108BUD transposase G9174_RS15685 ENOG4108BUD transposase G9174_RS15720 ENOG4108BUD transposase G9174_RS15875 ENOG4108TFU terminase (Small subunit) G9174_RS15925 ENOG4108R1E Serine threonine protein phosphatase 1 G9174_RS15930 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 G9174_RS16040 ENOG4108EU3 peptide transport system, permease G9174_RS16045 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein G9174_RS16050 ENOG4108JQ2 peptide transport system atp-binding protein G9174_RS16055 ENOG4105ETS cytosine purines uracil thiamine allantoin G9174_RS16065 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G9174_RS16070 ENOG4105Q4T oxidoreductase G9174_RS16075 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) G9174_RS16085 ENOG4105N2W Transcriptional regulator G9174_RS16090 ENOG41061RM osmotically inducible lipoprotein G9174_RS16095 ENOG4108ZJT translation initiation factor, Sui1 G9174_RS16105 ENOG4105CFV Tetratricopeptide repeat protein G9174_RS16110 ENOG4105Q4A inner membrane protein yciS G9174_RS16115 ENOG4105EYK Phosphatidylglycerophosphatase B G9174_RS16120 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) G9174_RS16125 ENOG4107QM5 aconitate hydratase G9174_RS16135 ENOG4107R11 Transcriptional regulator G9174_RS16140 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G9174_RS16145 ENOG4105RKX Protein of unknown function (DUF2498) G9174_RS16150 ENOG4105ERU peptidase G9174_RS16160 ENOG4105UBK short-chain dehydrogenase reductase G9174_RS16165 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G9174_RS16175 ENOG4105ETT transcriptional Regulator, LysR family G9174_RS16185 ENOG4107RTD sua5 ycio yrdc ywlc family protein G9174_RS16190 ENOG4105DB7 PHP domain protein G9174_RS16195 ENOG4105CRQ synthase (Component I) G9174_RS16200 ENOG4108EFP Anthranilate synthase component II G9174_RS16205 ENOG4105DK0 Indole-3-glycerol phosphate synthase G9174_RS16210 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G9174_RS16215 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G9174_RS16260 ENOG4108IU3 tonb-dependent siderophore receptor G9174_RS16265 ENOG4107E2E PKHD-type hydroxylase G9174_RS16270 ENOG4105EIF outer membrane protein W G9174_RS16275 ENOG4105PI0 Ferredoxin G9174_RS16280 ENOG4108S3I UPF0259 membrane protein G9174_RS16285 ENOG4107835 probably involved in intracellular septation (By similarity) G9174_RS16290 ENOG4107RNH Outer membrane receptor FepA G9174_RS16295 ENOG4105NAU thioesterase Superfamily protein G9174_RS16300 ENOG4107PN8 YfeABCD locus regulator G9174_RS16305 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 G9174_RS16310 ENOG4105CHR reductase G9174_RS16315 ENOG4107K5X Membrane-bound metal-dependent hydrolase G9174_RS16320 ENOG4108ETY sodium dicarboxylate symporter G9174_RS16325 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) G9174_RS16330 ENOG4105CH6 catalase G9174_RS16335 ENOG410901P UPF0249 protein G9174_RS16340 ENOG4105F8D glycoside hydrolase family 4 G9174_RS16345 ENOG4105EZV Transcriptional regulator G9174_RS16350 ENOG4105VCP PTS System G9174_RS16355 ENOG4105CK1 PTS System G9174_RS16365 ENOG4105VZJ PTS System G9174_RS16370 ENOG4105KKI DNA-binding transcriptional activator OsmE G9174_RS16380 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) G9174_RS16385 ENOG4108SPG Periplasmic Protein G9174_RS16395 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) G9174_RS16400 ENOG4105C26 Dehydrogenase G9174_RS16405 ENOG4105F4X arginine G9174_RS16415 ENOG4105CGK Exodeoxyribonuclease III G9174_RS16420 ENOG4108RSN SNARE associated Golgi G9174_RS16425 ENOG4108N5C SNARE associated Golgi protein-related protein G9174_RS16430 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9174_RS16435 ENOG4105VNH ABC transporter solute-binding protein G9174_RS16440 ENOG4105CXZ ABC transporter, permease G9174_RS16445 ENOG4108VGW abc transporter atp-binding protein G9174_RS16450 ENOG4107RM6 sulfurtransferase G9174_RS16455 ENOG4108T9J Cdp-alcohol phosphatidyltransferase G9174_RS16460 ENOG4105M6F mutator MutT protein G9174_RS16465 ENOG4105D82 Glutamate dehydrogenase G9174_RS16475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G9174_RS16480 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) G9174_RS16485 ENOG4105SBG acid phosphatase G9174_RS16495 ENOG41069NU Nitroreductase G9174_RS16500 ENOG4105D07 Signal peptide peptidase, SppA G9174_RS16505 ENOG4105HDK L-asparaginase G9174_RS16510 ENOG4108RWI nicotinamidase G9174_RS16515 ENOG4108KUU Inner membrane metabolite transport protein ydjE G9174_RS16520 ENOG4105E98 transcriptional regulator DeoR family G9174_RS16525 ENOG4105CPC Aldo Keto reductase G9174_RS16530 ENOG4107UH8 sugar kinase G9174_RS16535 ENOG4105D2N Aldolase G9174_RS16540 ENOG4105CPQ Dehydrogenase G9174_RS16545 ENOG4107TE1 transport protein G9174_RS16550 ENOG4105CPQ Dehydrogenase G9174_RS16560 ENOG4105N1F Hnh endonuclease G9174_RS16565 ENOG4105VUT cytoplasmic protein G9174_RS16570 ENOG4105E0X reductase G9174_RS16575 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G9174_RS16580 ENOG4105DSB aldose 1-epimerase G9174_RS16585 ENOG4105CV8 reductase G9174_RS16590 ENOG4105GNX MltA-interacting MipA family protein G9174_RS16595 ENOG4105CYN Serine protein kinase G9174_RS16600 ENOG4106AKX UPF0229 protein G9174_RS16610 ENOG4108V06 Glutathione peroxidase G9174_RS16635 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G9174_RS16640 ENOG4105CBN LysR family transcriptional regulator G9174_RS16645 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G9174_RS16650 ENOG4105KT5 UmuD protein G9174_RS16655 ENOG4105EKQ RNA-directed DNA polymerase G9174_RS16660 ENOG4105Y50 Virulence Protein G9174_RS16665 ENOG4108XNZ glycosyl transferase G9174_RS16670 ENOG4108KXH Ybak prolyl-tRNA synthetase associated G9174_RS16675 ENOG4108VMM UPF0756 membrane protein G9174_RS16680 ENOG4105R1U AraC Family Transcriptional Regulator G9174_RS16685 ENOG4105DJ2 Major Facilitator Superfamily G9174_RS16690 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G9174_RS16695 ENOG4105EWC Purine nucleoside phosphorylase G9174_RS16700 ENOG4105K78 MarR family Transcriptional regulator G9174_RS16705 ENOG4105UCG Domain of unknown function (DUF333) G9174_RS16710 ENOG410620I Diguanylate cyclase G9174_RS16715 ENOG4106G4W G9174_RS16730 ENOG4105S5I Membrane G9174_RS16735 ENOG4108NIW Leucine export protein LeuE G9174_RS16740 ENOG4105D1S lipid A biosynthesis G9174_RS16750 ENOG4105DHT Metal Dependent Phosphohydrolase G9174_RS16755 ENOG4106TD9 Diguanylate cyclase G9174_RS16760 ENOG4107RSM transcriptional regulator G9174_RS16765 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G9174_RS16795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G9174_RS16800 ENOG4105C4M (Ubiquinol oxidase) subunit I G9174_RS16805 ENOG4105WEF catalase G9174_RS16810 ENOG4108N8X transition metal ion binding G9174_RS16815 ENOG4108Z9Z response to DNA damage stimulus G9174_RS16825 ENOG4105E2A Dehydrogenase G9174_RS16830 ENOG4105XDF Protein of unknown function (DUF1272) G9174_RS16850 ENOG4108ZHR arsR family transcriptional regulator G9174_RS16855 ENOG4108HMX isocitrate dehydrogenase (NADP) G9174_RS16870 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G9174_RS16875 ENOG41075W9 High frequency lysogenization protein HflD homolog G9174_RS16880 ENOG4107QTF adenylosuccinate lyase G9174_RS16900 ENOG4105IFJ Histidine kinase G9174_RS16905 ENOG4105EZE Cupin 4 family protein G9174_RS16925 ENOG4105D38 putrescine abc transporter G9174_RS16930 ENOG4108HM4 ABC transporter G9174_RS16940 ENOG4105CEY Amp-dependent synthetase and ligase G9174_RS16950 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G9174_RS16955 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) G9174_RS16960 ENOG4105D60 lipoprotein releasing system transmembrane protein G9174_RS16965 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G9174_RS16970 ENOG4105D60 lipoprotein releasing system transmembrane protein G9174_RS16980 ENOG4108JA2 transcriptioN-repair coupling factor G9174_RS16985 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G9174_RS16990 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction G9174_RS17000 ENOG4108IND Tetr family transcriptional regulator G9174_RS17015 ENOG4107MBR 17 kDa surface antigen G9174_RS17020 ENOG4105CEP NADH dehydrogenase G9174_RS17025 ENOG4105D0Y UPF0227 protein G9174_RS17040 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) G9174_RS17045 ENOG41090DQ Lipoprotein G9174_RS17050 ENOG4105K59 histidine triad (HIT) protein G9174_RS17055 ENOG4105CI1 PTS System G9174_RS17060 ENOG4105F8V Hydrolase, tatD family G9174_RS17065 ENOG4107QRG dna polymerase iii G9174_RS17070 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G9174_RS17075 ENOG4105HHA aminodeoxychorismate lyase G9174_RS17080 ENOG4105YAZ 4-amino-4-deoxychorismate lyase G9174_RS17085 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G9174_RS17090 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G9174_RS17095 ENOG4105CHR reductase G9174_RS17100 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G9174_RS17105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G9174_RS17110 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) G9174_RS17115 ENOG4105VGS 50s ribosomal protein l32 G9174_RS17120 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G9174_RS17125 ENOG4108UHJ MAF-like protein G9174_RS17130 ENOG4105EI2 Pseudouridine synthase G9174_RS17140 ENOG4107QQB Ribonuclease E G9174_RS17145 ENOG4105CR8 Transcriptional regulator G9174_RS17150 ENOG4105EQ0 Major Facilitator superfamily G9174_RS17155 ENOG4105CJR Integral membrane protein (MviN G9174_RS17160 ENOG4105EP9 oxidoreductase G9174_RS17165 ENOG4108YXG UPF0502 protein G9174_RS17170 ENOG4105D9U N-acetyltransferase G9174_RS17175 ENOG4105EV4 Multidrug resistance protein mdtH G9174_RS17180 ENOG4105F3T (LipO)protein G9174_RS17185 ENOG4105EKE dihydroorotase G9174_RS17190 ENOG4105MEA DNA damage-inducible protein i G9174_RS17195 ENOG4105PVA Biofilm formation regulatory protein BssS G9174_RS17205 ENOG4106974 biofilm formation G9174_RS17215 ENOG4105D1S lipid A biosynthesis G9174_RS17225 ENOG4108W47 Acidic protein msyB G9174_RS17230 ENOG4105NAC (LipO)protein G9174_RS17235 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) G9174_RS17245 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) G9174_RS17260 ENOG4108UQ5 membrane protein YcdZ G9174_RS17265 ENOG4107XHZ cytoplasmic chaperone TorD family protein G9174_RS17275 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G9174_RS17295 ENOG4105HEI LysR family (Transcriptional regulator G9174_RS17300 ENOG4105EUB pirin domain protein G9174_RS17305 ENOG4105CHJ isochorismatase hydrolase G9174_RS17315 ENOG4108Z33 Thiol disulfide Interchange Protein G9174_RS17320 ENOG4105D5M phosphate starvation-inducible protein G9174_RS17325 ENOG4105DBE peroxidase G9174_RS17330 ENOG410650H (LipO)protein G9174_RS17340 ENOG4105D9N nucleoside G9174_RS17350 ENOG4105CK7 Sodium proline symporter G9174_RS17355 ENOG4105C26 Dehydrogenase G9174_RS17365 ENOG4108R86 Transcriptional regulator G9174_RS17370 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) G9174_RS17375 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G9174_RS17380 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) G9174_RS17385 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G9174_RS17390 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) G9174_RS17395 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) G9174_RS17400 ENOG4105C2W permease G9174_RS17410 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 G9174_RS17425 ENOG4105XH3 G9174_RS17430 ENOG4105D6F Phosphatase G9174_RS17440 ENOG4105CHR reductase G9174_RS17455 ENOG4105CUB amino acid G9174_RS17460 ENOG4105CFQ glutamine synthetase G9174_RS17465 ENOG4108Z86 Glutamine amidotransferase G9174_RS17470 ENOG4107VRI Transcriptional regulator G9174_RS17475 ENOG4105C26 Dehydrogenase G9174_RS17480 ENOG4105CJP fad dependent oxidoreductase G9174_RS17485 ENOG4105EJC lysr family transcriptional regulator G9174_RS17490 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G9174_RS17495 ENOG4105C94 Transporter G9174_RS17500 ENOG4105DVW rieske (2Fe-2S) G9174_RS17505 ENOG4105C26 Dehydrogenase G9174_RS17510 ENOG4105E3J oxidoreductase G9174_RS17530 ENOG4107QSI ABC, transporter G9174_RS17535 ENOG4108MN8 Membrane G9174_RS17545 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 G9174_RS17550 ENOG4108UQN AraC family transcriptional regulator G9174_RS17555 ENOG4108V1U phospholipid-binding protein G9174_RS17560 ENOG4105DR4 Methyltransferase G9174_RS17565 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) G9174_RS17570 ENOG4105K4P CoA-binding domain protein G9174_RS17580 ENOG41088T4 Helicase IV G9174_RS17585 ENOG410901E Membrane G9174_RS17590 ENOG4105EM2 membrane G9174_RS17595 ENOG4108RZ1 DNA transformation protein G9174_RS17600 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) G9174_RS17605 ENOG4105UYK outer membrane protein a G9174_RS17610 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) G9174_RS17615 ENOG4105DAN ATP-dependent protease G9174_RS17620 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) G9174_RS17625 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) G9174_RS17630 ENOG4108Q2G (LipO)protein G9174_RS17635 ENOG4105DY2 Paraquat-inducible protein b G9174_RS17640 ENOG4105F1S paraquat-inducible protein a G9174_RS17645 ENOG4105C5H ABC transporter G9174_RS17650 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G9174_RS17655 ENOG4105QVC MOSC domain-containing protein G9174_RS17660 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) G9174_RS17670 ENOG4108UZX fmn reductase G9174_RS17675 ENOG4105GVF (ABC) transporter G9174_RS17680 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G9174_RS17685 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G9174_RS17695 ENOG4105CD8 aminopeptidase N G9174_RS17700 ENOG4107RH7 Nicotinate phosphoribosyltransferase G9174_RS17705 ENOG4105CH2 amidohydrolase G9174_RS17710 ENOG4105CE7 Amidase, hydantoinase carbamoylase family G9174_RS17715 ENOG4105C44 Serine transporter G9174_RS17720 ENOG4107RCH Diaminopropionate ammonia-lyase G9174_RS17730 ENOG4105C5S asparaginyl-tRNA synthetase G9174_RS17735 ENOG4105ZIT Porin Gram-negative type G9174_RS17740 ENOG4105CGF Aromatic amino acid aminotransferase G9174_RS17745 ENOG4105C5X domain protein G9174_RS17750 ENOG4105EAQ (twin-arginine translocation) pathway signal G9174_RS17755 ENOG4105DIT ErfK YbiS YcfS YnhG family protein G9174_RS17760 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) G9174_RS17765 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) G9174_RS17770 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) G9174_RS17775 ENOG4106371 Methyltransferase G9174_RS17780 ENOG4107S90 membrAne G9174_RS17785 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups G9174_RS17790 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G9174_RS17795 ENOG4105W49 UPF0434 protein G9174_RS17800 ENOG4105T0Z Conserved Protein G9174_RS17805 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G9174_RS17810 ENOG4105BZ1 (ABC) transporter G9174_RS17815 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 G9174_RS17820 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G9174_RS17825 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G9174_RS17830 ENOG4105CAT Cytidine monophosphate kinase G9174_RS17835 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G9174_RS17840 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G9174_RS17845 ENOG4107VMU Membrane G9174_RS17850 ENOG4105DDY UPF0142 protein ycaO G9174_RS17855 ENOG4105TMB Formate nitrite transporter G9174_RS17860 ENOG4105C6N Formate acetyltransferase G9174_RS17865 ENOG4105F1A Pyruvate formate-lyase G9174_RS17870 ENOG4108ISG Major Facilitator G9174_RS17875 ENOG4107KGK dmso reductase anchor subunit G9174_RS17880 ENOG4105QAX Iron-sulfur G9174_RS17885 ENOG4107QY8 reductase G9174_RS17890 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G9174_RS17895 ENOG4105D1H recombination factor protein RarA G9174_RS17900 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) G9174_RS17905 ENOG4105CNU cell division protein FtsK G9174_RS17910 ENOG4105EW9 transcriptional regulator AsnC family G9174_RS17915 ENOG4105C3M thioredoxin reductase G9174_RS17920 ENOG4108JJ9 ABC, transporter G9174_RS17925 ENOG4108JJ8 (ABC) transporter G9174_RS17930 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G9174_RS17935 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G9174_RS17940 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G9174_RS17945 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G9174_RS17950 ENOG4105VEQ Cold shock protein G9174_RS17960 ENOG4105DJY efflux transporter, rnd family, mfp subunit G9174_RS17965 ENOG4105CPB ATP-dependent endonuclease of the OLD family G9174_RS17970 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9174_RS17975 ENOG4105DWU Membrane G9174_RS17985 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9174_RS17995 ENOG4105C7K acetolactate synthase G9174_RS18000 ENOG4105C5W Aldolase G9174_RS18005 ENOG4105CGD Nad-dependent epimerase dehydratase G9174_RS18010 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase G9174_RS18015 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G9174_RS18025 ENOG41064MM (LipO)protein G9174_RS18030 ENOG4105E5Z arginine transporter ATP-binding subunit G9174_RS18035 ENOG4106PMH Extracellular solute-binding protein family 3 G9174_RS18040 ENOG4105GBT ABC transporter G9174_RS18045 ENOG4105DMR ABC, transporter G9174_RS18050 ENOG4106TNF Periplasmic binding protein G9174_RS18055 ENOG4105BZU Histidine kinase G9174_RS18060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9174_RS18065 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) G9174_RS18070 ENOG4105RBQ inner membrane protein ybjO G9174_RS18075 ENOG4105D38 putrescine abc transporter G9174_RS18080 ENOG4105F38 ABC transporter, permease G9174_RS18085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9174_RS18090 ENOG4107RUE extracellular solute-binding protein family 1 G9174_RS18095 ENOG4108RMJ sensory transduction regulator G9174_RS18110 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress G9174_RS18115 ENOG41090BQ Glutaredoxin G9174_RS18120 ENOG4105GWF inner membrane protein YbjM G9174_RS18125 ENOG4105D0C transport protein G9174_RS18130 ENOG4105ZTC transcriptional activator, Ogr delta G9174_RS18285 ENOG4105ED4 portal protein G9174_RS18310 ENOG4105EKQ RNA-directed DNA polymerase G9174_RS18315 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G9174_RS18320 ENOG4108RFG Tetr family transcriptional regulator G9174_RS18325 ENOG4106UW1 Major Facilitator superfamily G9174_RS18330 ENOG4108HCJ Hydrolase G9174_RS18335 ENOG4107QF7 multi-drug G9174_RS18340 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G9174_RS18345 ENOG4107FB0 transcriptional regulator DeoR family G9174_RS18350 ENOG4105DZ1 carboxypeptidase G9174_RS18360 ENOG4108TGY Glutathione S-transferase G9174_RS18365 ENOG4105D8V Glucose sorbosone dehydrogenase G9174_RS18370 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway G9174_RS18375 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G9174_RS18380 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) G9174_RS18385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9174_RS18390 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G9174_RS18395 ENOG4105DEF Extracellular solute-binding protein, family 5 G9174_RS18400 ENOG4108JQ6 ABC transporter G9174_RS18405 ENOG4105D44 asparaginase G9174_RS18410 ENOG4105CVM Molybdenum cofactor synthesis domain protein G9174_RS18415 ENOG4105D06 uba thif-type nad fad binding protein G9174_RS18420 ENOG4105F1A Pyruvate formate-lyase G9174_RS18430 ENOG4108HCJ Hydrolase G9174_RS18435 ENOG41072TH Protein of unknown function (DUF1479) G9174_RS18440 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS18445 ENOG4105DPW Major facilitator superfamily MFS_1 G9174_RS18455 ENOG4105C5H ABC transporter G9174_RS18460 ENOG4105M2Z protein tyrosine serine phosphatase G9174_RS18465 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G9174_RS18470 ENOG4108TZY GntR Family Transcriptional Regulator G9174_RS18475 ENOG4105CS2 ec 3.2.1.21 G9174_RS18480 ENOG4105F4P )-transporter G9174_RS18485 ENOG4105KST dependent repressor G9174_RS18495 ENOG4108I6E Sulfatase G9174_RS18500 ENOG4108T1M outer membrane protein x G9174_RS18510 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G9174_RS18515 ENOG4107R0W ABC transporter G9174_RS18520 ENOG4105E5Q amino acid AbC transporter G9174_RS18525 ENOG4105CDA abc transporter atp-binding protein G9174_RS18530 ENOG4105D8X mechanosensitive ion channel G9174_RS18535 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) G9174_RS18540 ENOG4105EW6 flavin reductase domain protein, FMN-binding G9174_RS18550 ENOG4105KSC Transcriptional regulator, TraR DksA family G9174_RS18555 ENOG4105VR4 UPF0379 protein ybiJ G9174_RS18560 ENOG4108MTB glycosyl transferase family G9174_RS18565 ENOG4105DVT helicase G9174_RS18570 ENOG4105C1J atp-dependent rna helicase G9174_RS18590 ENOG4105DJB Major Facilitator Superfamily G9174_RS18600 ENOG4108PZW LysR family Transcriptional regulator G9174_RS18605 ENOG4107MVR Transcriptional regulator G9174_RS18610 ENOG4105D0S secretion protein (HlyD G9174_RS18615 ENOG4105CJ1 ABC, transporter G9174_RS18620 ENOG4107QWP ABC-2 type transporter G9174_RS18625 ENOG4107QWP ABC-2 type transporter G9174_RS18630 ENOG4105I9U inner membrane protein ybhQ G9174_RS18635 ENOG4105X23 Endonuclease Exonuclease phosphatase G9174_RS18640 ENOG4105DZQ phospholipase D Transphosphatidylase G9174_RS18645 ENOG4107UXM Membrane G9174_RS18650 ENOG4105HFZ Membrane G9174_RS18655 ENOG4108ZAF Molybdopterin G9174_RS18660 ENOG4105M00 molybdopterin converting factor, subunit 1 G9174_RS18665 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G9174_RS18670 ENOG4108RIR Molybdenum cofactor biosynthesis protein G9174_RS18675 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G9174_RS18680 ENOG4105CHW UPF0052 protein G9174_RS18685 ENOG4105DIJ Phosphoethanolamine transferase G9174_RS18690 ENOG4105XJC Two component transcriptional regulator (Winged helix family G9174_RS18695 ENOG4105ECM Sensor protein basS pmrB G9174_RS18700 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G9174_RS18705 ENOG4105EKQ RNA-directed DNA polymerase G9174_RS18715 ENOG4108IV0 ABC, transporter G9174_RS18725 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G9174_RS18730 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G9174_RS18735 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G9174_RS18740 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G9174_RS18745 ENOG4108V1U phospholipid-binding protein G9174_RS18750 ENOG4105C85 amino acid G9174_RS18755 ENOG4105C84 Histidine ammonia-lyase G9174_RS18760 ENOG4105CGP Urocanate hydratase G9174_RS18775 ENOG41088SP formiminoglutamate hydrolase G9174_RS18780 ENOG4105CI2 imidazolone-5-propionate hydrolase G9174_RS18785 ENOG4105NBR Pectinesterase G9174_RS18820 ENOG4108XDN Transcriptional regulator G9174_RS18825 ENOG4105BZU Histidine kinase G9174_RS18830 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component G9174_RS18845 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G9174_RS18850 ENOG4108K4B hydrolase G9174_RS18855 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G9174_RS18860 ENOG4105E0C molybdate abc transporter G9174_RS18865 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G9174_RS18875 ENOG4105F4R Transcriptional regulator mode G9174_RS18880 ENOG4105DKW ABC transporter G9174_RS18885 ENOG4105CMR udp-glucose 4-epimerase G9174_RS18890 ENOG4105F0Z galactose-1-phosphate uridylyltransferase G9174_RS18895 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G9174_RS18900 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G9174_RS18905 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G9174_RS18910 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G9174_RS18915 ENOG4105JND homeobox protein G9174_RS18920 ENOG4105PGM cation diffusion facilitator family transporter G9174_RS18925 ENOG4106Z1T Nicotinamide Mononucleotide Transporter G9174_RS18930 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G9174_RS18975 ENOG4105UFD tol-pal system protein YbgF G9174_RS18980 ENOG4105KCK Peptidoglycan-associated lipoprotein G9174_RS18990 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA G9174_RS19000 ENOG4105E02 MotA TolQ exbB proton channel G9174_RS19005 ENOG4107YD3 Thioesterase G9174_RS19010 ENOG4105KJB cyd operon protein YbgE G9174_RS19020 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G9174_RS19025 ENOG4105C4M (Ubiquinol oxidase) subunit I G9174_RS19030 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G9174_RS19035 ENOG4105CMV Succinyl-CoA synthetase subunit beta G9174_RS19040 ENOG4105C7S Dehydrogenase G9174_RS19045 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G9174_RS19050 ENOG4105E33 succinate dehydrogenase G9174_RS19055 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G9174_RS19060 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein G9174_RS19065 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit G9174_RS19070 ENOG4105BZN citrate synthase G9174_RS19075 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) G9174_RS19095 ENOG4105E7W lamb ycsf family protein G9174_RS19100 ENOG4107R7A Allophanate hydrolase subunit 2 G9174_RS19105 ENOG4105P4J Allophanate hydrolase, subunit 1 G9174_RS19110 ENOG4107QNR UPF0135 protein G9174_RS19115 ENOG4105DUX Transporter G9174_RS19120 ENOG4105CVP deoxyribo-dipyrimidine photolyase G9174_RS19125 ENOG4105XIQ Protein of unknown function (DUF2517) G9174_RS19135 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G9174_RS19140 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G9174_RS19145 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G9174_RS19150 ENOG4105C08 Histidine kinase G9174_RS19155 ENOG4105EEX Two component transcriptional regulator (Winged helix family G9174_RS19165 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 G9174_RS19170 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) G9174_RS19175 ENOG4105EV9 Alpha Beta Hydrolase G9174_RS19180 ENOG4105NNH LexA regulated protein G9174_RS19185 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) G9174_RS19190 ENOG41090R7 Ferric uptake G9174_RS19200 ENOG4105GX6 (LipO)protein G9174_RS19205 ENOG4105J5J Outer membrane porin G9174_RS19215 ENOG4105CX6 glutaminyL-tRNA synthetase G9174_RS19220 ENOG4105CI1 PTS System G9174_RS19225 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G9174_RS19230 ENOG4105CE4 GlcNAc 6-P deacetylase G9174_RS19235 ENOG4105E2R ROK family G9174_RS19240 ENOG4105D4U had-superfamily hydrolase, subfamily iia G9174_RS19245 ENOG4105CAQ asparagine synthetase G9174_RS19285 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G9174_RS19290 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G9174_RS19295 ENOG4105C9A Phoh family G9174_RS19300 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G9174_RS19305 ENOG4108JU5 Magnesium and cobalt efflux protein G9174_RS19310 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G9174_RS19315 ENOG4107RP9 extracellular solute-binding protein, family 3 G9174_RS19320 ENOG4105EAD ABC transporter G9174_RS19325 ENOG4105DRP amino acid AbC transporter G9174_RS19330 ENOG4105CDA abc transporter atp-binding protein G9174_RS19345 ENOG4107PAI alpha helical protein G9174_RS19350 ENOG4105C8T Leucyl-tRNA synthetase G9174_RS19360 ENOG4105DJF DNA polymerase III, delta' subunit G9174_RS19365 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G9174_RS19370 ENOG4108TGR phosphatase G9174_RS19375 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G9174_RS19380 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G9174_RS19385 ENOG4105CJN penicillin-binding protein G9174_RS19390 ENOG4105CNI cell division protein FtsW G9174_RS19395 ENOG4105K6T rare lipoprotein A G9174_RS19400 ENOG4105DZ1 carboxypeptidase G9174_RS19405 ENOG4108Z43 UPF0250 protein G9174_RS19410 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G9174_RS19415 ENOG41064T2 transcriptional regulator, lysR family G9174_RS19420 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G9174_RS19425 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) G9174_RS19445 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) G9174_RS19450 ENOG4105CEE C4-dicarboxylate transporter G9174_RS19455 ENOG4105KTS ribonuclease G9174_RS19460 ENOG4105NXH GreA GreB family elongation factor G9174_RS19465 ENOG4108U51 Universal stress protein G9174_RS19470 ENOG4108JU3 Alkyl hydroperoxide reductase G9174_RS19475 ENOG4105D3R alkyl hydroperoxide reductase G9174_RS19480 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase G9174_RS19485 ENOG4105DQS Transcriptional regulator G9174_RS19490 ENOG4105BZV Phosphoadenosine phosphosulfate reductase G9174_RS19495 ENOG4105GTN ParB Domain Protein Nuclease G9174_RS19500 ENOG4105CHM Aminotransferase G9174_RS19505 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) G9174_RS19510 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) G9174_RS19525 ENOG4105C2J ABC transporter G9174_RS19535 ENOG4105CNN ABC, transporter G9174_RS19545 ENOG4108M3J Dehydrogenase G9174_RS19555 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) G9174_RS19560 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin G9174_RS19570 ENOG4105DZC cytosine deaminase G9174_RS19580 ENOG4105ECY inositol monophosphatase G9174_RS19585 ENOG4105CXY transporter G9174_RS19590 ENOG4105D6F Phosphatase G9174_RS19595 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G9174_RS19600 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) G9174_RS19615 ENOG4105CNN ABC, transporter G9174_RS19620 ENOG4105C2J ABC transporter G9174_RS19625 ENOG4107SCQ Iron-containing alcohol dehydrogenase G9174_RS19630 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G9174_RS19645 ENOG4105VCD cytoplasmic protein G9174_RS19650 ENOG4105D22 carbon starvation protein G9174_RS19655 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) G9174_RS19660 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G9174_RS19665 ENOG4105WQI isochorismatase G9174_RS19670 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G9174_RS19675 ENOG4105E4F Isochorismate synthase G9174_RS19680 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein G9174_RS19685 ENOG4105E8G Major facilitator Superfamily G9174_RS19690 ENOG4105DQ5 transport system permease protein G9174_RS19695 ENOG4105TVJ transport system, permease G9174_RS19700 ENOG4105E0A ABC, transporter G9174_RS19705 ENOG4105C0W non-ribosomal peptide synthetase G9174_RS19710 ENOG41085A6 mbth domain-containing protein G9174_RS19715 ENOG4105E93 esterase G9174_RS19720 ENOG4107RNH Outer membrane receptor FepA G9174_RS19725 ENOG4108TSE Transferase G9174_RS19730 ENOG4108IUS Transketolase G9174_RS19735 ENOG4108HHA Transketolase G9174_RS19740 ENOG4105DKT Transcriptional regulator G9174_RS19745 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G9174_RS19750 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9174_RS19760 ENOG4105C2J ABC transporter G9174_RS19765 ENOG4105CNN ABC, transporter G9174_RS19775 ENOG4108R85 Short chain dehydrogenase G9174_RS19785 ENOG410810E transcriptional regulator, lysR family G9174_RS19790 ENOG4105CUY Mechanosensitive ion channel G9174_RS19795 ENOG4108WN0 inhibitor of vertebrate lysozyme G9174_RS19800 ENOG4105C94 Transporter G9174_RS19815 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G9174_RS19825 ENOG4105DEF Extracellular solute-binding protein, family 5 G9174_RS19830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G9174_RS19835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9174_RS19840 ENOG4105C3U ABC transporter G9174_RS19845 ENOG4108JQ7 (ABC) transporter G9174_RS19850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G9174_RS19855 ENOG4105EMU Dehydrogenase G9174_RS19865 ENOG4105GBT ABC transporter G9174_RS19870 ENOG4105DRP amino acid AbC transporter G9174_RS19875 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) G9174_RS19885 ENOG4105CHM Aminotransferase G9174_RS19890 ENOG4105T38 integral membrane protein G9174_RS19895 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) G9174_RS19900 ENOG4108T58 Mg2 transport protein CorA G9174_RS19935 ENOG4105MSB protein, conserved in bacteria G9174_RS19940 ENOG4108RCM Nitroreductase G9174_RS19950 ENOG4108IQ3 PTS system G9174_RS19960 ENOG4105F3R pts system mannose fructose sorbose family iid G9174_RS19965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G9174_RS19970 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine G9174_RS19975 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G9174_RS19995 ENOG4105CUY Mechanosensitive ion channel G9174_RS20015 ENOG4108GWT fimbrillin MatB G9174_RS20025 ENOG4108N3D putative enzyme G9174_RS20030 ENOG4106PYX Receptor G9174_RS20040 ENOG4105ISV protein with bipartite regulator domain G9174_RS20050 ENOG4105CK5 oxidoreductase G9174_RS20060 ENOG4105EAA nucleoside G9174_RS20065 ENOG4105C85 amino acid G9174_RS20075 ENOG4108NS2 receptor G9174_RS20080 ENOG4105C26 Dehydrogenase G9174_RS20085 ENOG4105CJP fad dependent oxidoreductase G9174_RS20095 ENOG4105CUB amino acid G9174_RS20105 ENOG4105DGU Histone deacetylase G9174_RS20115 ENOG4108UAJ Transcriptional regulator G9174_RS20125 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G9174_RS20140 ENOG4105CPC Aldo Keto reductase G9174_RS20145 ENOG4105E89 ABC transporter G9174_RS20150 ENOG4105CH2 amidohydrolase G9174_RS20180 ENOG4105EHG Permease protein G9174_RS20185 ENOG4105E0A ABC, transporter G9174_RS20190 ENOG4105EFX secretion protein, HlyD family G9174_RS20195 ENOG4105KK7 inner membrane protein YiaW G9174_RS20205 ENOG4105D7K pfkb domain protein G9174_RS20210 ENOG4108M0B Sucrose porin G9174_RS20215 ENOG4105C5Y PTS System G9174_RS20220 ENOG4108HKT sucrose-6-phosphate hydrolase G9174_RS20225 ENOG4105WBN Transcriptional regulator (LacI family G9174_RS20235 ENOG4108HWV )-transporter G9174_RS20240 ENOG4105C2J ABC transporter G9174_RS20280 ENOG4105CRK lysyL-tRNA synthetase G9174_RS20285 ENOG4105DUX Transporter G9174_RS20290 ENOG4105CXN decarboxylase G9174_RS20295 ENOG4105D5Q Arginine ornithine antiporter G9174_RS20300 ENOG4108M3R transcriptional activator CadC G9174_RS20310 ENOG4105D1S lipid A biosynthesis G9174_RS20325 ENOG4105CW0 outer membrane usher protein G9174_RS20330 ENOG4105GQR Chaperone G9174_RS20335 ENOG4105X0I Fimbrial G9174_RS20350 ENOG4105BZN citrate synthase G9174_RS20380 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G9174_RS20385 ENOG4105WQ3 Rna-binding protein G9174_RS20390 ENOG4105C8N cysteinyl-tRNA synthetase G9174_RS20395 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G9174_RS20400 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G9174_RS20410 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G9174_RS20415 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G9174_RS20435 ENOG4105CV6 ABC transporter, permease G9174_RS20440 ENOG4108I0Y (ABC) transporter G9174_RS20445 ENOG4108UJV acyl-CoA thioesterase i G9174_RS20450 ENOG4105E1F short-chain dehydrogenase reductase G9174_RS20455 ENOG4107QR8 Thioredoxin G9174_RS20460 ENOG4105C4B ABC transporter, permease G9174_RS20465 ENOG41083J0 (ABC) transporter G9174_RS20470 ENOG4107QX8 SPFH domain, Band 7 family protein G9174_RS20475 ENOG4105G5H Membrane G9174_RS20480 ENOG4108Z6Z Transcriptional regulator G9174_RS20485 ENOG4105C59 p-type ATPase G9174_RS20490 ENOG4105MBR gumn family G9174_RS20495 ENOG4108Z66 YbaK ebsC protein G9174_RS20500 ENOG4105CGH 5'-nucleotidase G9174_RS20505 ENOG4105EU0 Major facilitator Superfamily G9174_RS20510 ENOG4105CKD glutathione-regulated potassium-efflux system protein G9174_RS20515 ENOG4107RE1 Inosine-guanosine kinase G9174_RS20525 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G9174_RS20530 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G9174_RS20535 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G9174_RS20540 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G9174_RS20545 ENOG4107QMP dna polymerase iii subunits gamma and tau G9174_RS20550 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G9174_RS20555 ENOG4105WD1 Membrane G9174_RS20560 ENOG4108URS primosomal replication protein n'' G9174_RS20565 ENOG4106428 Protein of unknown function (DUF2496) G9174_RS20570 ENOG4105DNE Transposase G9174_RS20575 ENOG4105EGS Mechanosensitive ion channel G9174_RS20580 ENOG4107XI7 Tetr family transcriptional regulator G9174_RS20585 ENOG4105C1P efflux transporter, rnd family, mfp subunit G9174_RS20590 ENOG4105BZS acriflavin resistance protein G9174_RS20595 ENOG4108UKR Biofilm formation regulator YbaJ G9174_RS20605 ENOG4108UW5 maltose o-acetyltransferase G9174_RS20615 ENOG4105GSJ Inner membrane protein ylaC G9174_RS20630 ENOG4105YK5 50S ribosomal protein L36 G9174_RS20640 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS20645 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G9174_RS20650 ENOG4105CI1 PTS System G9174_RS20655 ENOG4105C4C beta-galactosidase G9174_RS20665 ENOG4105EG2 ABC transporter, permease G9174_RS20675 ENOG4107FKK extracellular solute-binding protein family 1 G9174_RS20685 ENOG41066DG (EAL) domain protein G9174_RS20690 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter G9174_RS20695 ENOG41061MD high-affinity nickel-transporter G9174_RS20700 ENOG4108VW9 Membrane G9174_RS20730 ENOG41080UX Methyltransferase G9174_RS20735 ENOG4108MNP Glycoprotein polysaccharide metabolism G9174_RS20740 ENOG4105C29 acyl-CoA thioesterase G9174_RS20745 ENOG4105BZU Histidine kinase G9174_RS20750 ENOG4108YZA Nitrogen regulatory protein pii G9174_RS20755 ENOG4105BZ1 (ABC) transporter G9174_RS20760 ENOG4105BZ1 (ABC) transporter G9174_RS20765 ENOG4108XM1 transcriptional regulator AsnC family G9174_RS20775 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) G9174_RS20780 ENOG4108NFA extracellular solute-binding protein G9174_RS20785 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G9174_RS20790 ENOG4108TGP Thioesterase superfamily protein G9174_RS20795 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G9174_RS20800 ENOG4105EIN peptidylprolyl cis-trans isomerase G9174_RS20805 ENOG4105K70 DNA-binding protein G9174_RS20810 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G9174_RS20815 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G9174_RS20825 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G9174_RS20830 ENOG4105M85 Bola protein G9174_RS20835 ENOG4105IEY (LipO)protein G9174_RS20840 ENOG4105EYM Major Facilitator superfamily G9174_RS20845 ENOG4105E2S oxidase) subunit II G9174_RS20850 ENOG4105BZ9 Cytochrome C oxidase, subunit I G9174_RS20855 ENOG4105CCU oxidase (Subunit III) G9174_RS20860 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G9174_RS20865 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G9174_RS20875 ENOG4107HP6 Transcriptional regulator G9174_RS20880 ENOG4105E2X shikimate dehydrogenase G9174_RS20885 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G9174_RS20895 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G9174_RS20905 ENOG4105D2S major facilitator superfamily G9174_RS20910 ENOG4105CIB oxidoreductase Domain protein G9174_RS20915 ENOG4107RDB Major Facilitator G9174_RS20925 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G9174_RS20930 ENOG4107S0N DJ-1 family G9174_RS20940 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) G9174_RS20945 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G9174_RS20950 ENOG4105CTB Polyprenyl synthetase G9174_RS20955 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G9174_RS20960 ENOG4105CPC Aldo Keto reductase G9174_RS20965 ENOG4108ZAI phosphatidylglycerophosphatase a G9174_RS20970 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G9174_RS20975 ENOG4107YIM Involved in the transcription termination process (By similarity) G9174_RS20980 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G9174_RS20985 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G9174_RS20990 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G9174_RS20995 ENOG4108KIC (LipO)protein G9174_RS21000 ENOG4105DRB nucleoside-specific channel-forming protein G9174_RS21015 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G9174_RS21020 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G9174_RS21025 ENOG4105VIE preprotein translocase, subunit YajC G9174_RS21030 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) G9174_RS21035 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G9174_RS21045 ENOG4108ZYK Acyl carrier protein phosphodiesterase G9174_RS21050 ENOG4105D3R alkyl hydroperoxide reductase G9174_RS21060 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia G9174_RS21075 ENOG4108MGF sugar kinase G9174_RS21085 ENOG4105CI2 imidazolone-5-propionate hydrolase G9174_RS21095 ENOG4105CHJ isochorismatase hydrolase G9174_RS21100 ENOG4105EQ1 Transcriptional regulator G9174_RS21105 ENOG4107R28 alpha amylase, catalytic region G9174_RS21110 ENOG4105C85 amino acid G9174_RS21115 ENOG4105CWM branched-chain amino acid transport system II carrier protein G9174_RS21120 ENOG4105BZU Histidine kinase G9174_RS21125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9174_RS21130 ENOG4107RH8 nuclease SbcCD subunit D G9174_RS21135 ENOG4105EYH Exonuclease G9174_RS21140 ENOG4105DKQ ROK family G9174_RS21145 ENOG4105DH7 May be involved in recombination (By similarity) G9174_RS21150 ENOG4105NBK UPF0345 protein G9174_RS21155 ENOG4105HBA AroM protein G9174_RS21160 ENOG4105SS3 G9174_RS21165 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G9174_RS21170 ENOG4105G4C Periplasmic ligand-binding sensor protein G9174_RS21175 ENOG4108UPT UPF0178 protein G9174_RS21180 ENOG4105II7 pyrroline-5-carboxylate reductase G9174_RS21185 ENOG4105VIF phosphate starvation-inducible protein G9174_RS21190 ENOG4105G6Z alkaline phosphatase G9174_RS21210 ENOG4105CPF Cell wall formation (By similarity) G9174_RS21215 ENOG4105UNH Membrane G9174_RS21220 ENOG4105FR5 inner membrane protein YaiY G9174_RS21225 ENOG4107QS8 (LipO)protein G9174_RS21230 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 G9174_RS21235 ENOG4108RWI nicotinamidase G9174_RS21240 ENOG4107R6D beta-lactam binding protein AmpH G9174_RS21245 ENOG4105D52 delta-aminolevulinic acid dehydratase G9174_RS21255 ENOG4105E2B Taurine dioxygenase G9174_RS21260 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G9174_RS21265 ENOG4108ETV ABC transporter G9174_RS21270 ENOG4106FTQ Taurine ABC transporter, periplasmic G9174_RS21275 ENOG4107QK5 Homocysteine s-methyltransferase G9174_RS21280 ENOG4108IQI permease G9174_RS21290 ENOG4105C85 amino acid G9174_RS21295 ENOG4105CPD ethanolamine ammonia-lyase G9174_RS21300 ENOG4107FQ9 ethanolamine ammonia-lyase G9174_RS21315 ENOG4105C32 Amino acid ABC transporter (Permease) G9174_RS21320 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G9174_RS21325 ENOG4105C0Z ABC transporter G9174_RS21330 ENOG4108IV0 ABC, transporter G9174_RS21340 ENOG4105CT1 (ABC) transporter G9174_RS21345 ENOG4105CDA abc transporter atp-binding protein G9174_RS21350 ENOG4105E5Q amino acid AbC transporter G9174_RS21355 ENOG4105DRP amino acid AbC transporter G9174_RS21365 ENOG4106PYX Receptor G9174_RS21370 ENOG4108N3D putative enzyme G9174_RS21375 ENOG4108NN8 Fimbrial protein G9174_RS21380 ENOG4108GWT fimbrillin MatB G9174_RS21385 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon G9174_RS21395 ENOG4105EHI Phosphonate ABC transporter, periplasmic G9174_RS21405 ENOG4105S7S phosphonate abc transporter G9174_RS21425 ENOG4108QBX (LipO)protein G9174_RS21430 ENOG4105FCK Membrane G9174_RS21435 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G9174_RS21440 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G9174_RS21450 ENOG4105DFP Integrase G9174_RS21455 ENOG4107QJE Chromosome Partitioning Protein G9174_RS21470 ENOG4105ZTC transcriptional activator, Ogr delta G9174_RS21515 ENOG4107R0V Pyruvate dehydrogenase G9174_RS21520 ENOG4105CPP Dehydrogenase, E1 component G9174_RS21540 ENOG41061GT Aldolase G9174_RS21550 ENOG4105CMG Carbohydrate kinase G9174_RS21555 ENOG4105CHR reductase G9174_RS21560 ENOG4108JQ1 Dehydrogenase G9174_RS21565 ENOG4105DT3 PTS system, galactitol-specific IIc component G9174_RS21570 ENOG4108TGY Glutathione S-transferase G9174_RS21575 ENOG4105DTA methyltransferase G9174_RS21580 ENOG4105YCT UPF0386 protein G9174_RS21590 ENOG4105D5U fad dependent oxidoreductase G9174_RS21595 ENOG4105C26 Dehydrogenase G9174_RS21600 ENOG4108JPW Aminotransferase G9174_RS21605 ENOG4105C85 amino acid G9174_RS21610 ENOG4108PVQ transcriptional regulator G9174_RS21615 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) G9174_RS21620 ENOG4105V1F Fermentation respiration switch protein G9174_RS21625 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) G9174_RS21630 ENOG4105CIN aminoacyl-histidine dipeptidase G9174_RS21635 ENOG4108HYG acetyltransferase G9174_RS21640 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G9174_RS21655 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) G9174_RS21660 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G9174_RS21665 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G9174_RS21670 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G9174_RS21675 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G9174_RS21680 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G9174_RS21685 ENOG4105F7V ErfK ybiS ycfS ynhG family protein G9174_RS21690 ENOG4105E7A Glutamine amidotransferase G9174_RS21695 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G9174_RS21700 ENOG4107QPN acyl-Coa dehydrogenase G9174_RS21705 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G9174_RS21710 ENOG4108VP3 Lysine exporter protein (LysE YggA) G9174_RS21715 ENOG41090KR LysR family transcriptional Regulator G9174_RS21725 ENOG4107RZZ dna polymerase iii epsilon subunit G9174_RS21730 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G9174_RS21735 ENOG4105D1A Methyltransferase G9174_RS21740 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G9174_RS21745 ENOG4105E9H Lytic Murein transglycosylase G9174_RS21750 ENOG4105F2W methyltransferase G9174_RS21760 ENOG4105F27 Major Facilitator G9174_RS21765 ENOG4105HEI LysR family (Transcriptional regulator G9174_RS21770 ENOG4105CV8 reductase G9174_RS21805 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G9174_RS21810 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G9174_RS21815 ENOG4108UMI ABC transporter, permease G9174_RS21820 ENOG4105D01 (LipO)protein G9174_RS21825 ENOG4108R8X outer membrane lipoprotein G9174_RS21830 ENOG4108R96 Methyltransferase, YaeB family G9174_RS21835 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G9174_RS21840 ENOG4108UY0 (LipO)protein G9174_RS21845 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion G9174_RS21850 ENOG4108YZN class I peptide chain release factor G9174_RS21855 ENOG4108VWS Yaeq family G9174_RS21860 ENOG4105W1I UPF0253 protein G9174_RS21865 ENOG4105M1T rho-binding antiterminator G9174_RS21870 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G9174_RS21875 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase G9174_RS21880 ENOG4105CXN decarboxylase G9174_RS21885 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G9174_RS21890 ENOG4105C0B DNA polymerase III (alpha subunit) G9174_RS21895 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G9174_RS21900 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G9174_RS21905 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G9174_RS21910 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G9174_RS21915 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G9174_RS21920 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) G9174_RS21930 ENOG4105DZP Membrane-associated zinc metalloprotease G9174_RS21935 ENOG4105KNE Phosphatidate cytidylyltransferase G9174_RS21945 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G9174_RS21955 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G9174_RS21960 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G9174_RS21965 ENOG4105CE9 30S ribosomal protein S2 G9174_RS21970 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G9174_RS21975 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G9174_RS21980 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) G9174_RS21985 ENOG4108T8E UPF0325 protein G9174_RS21990 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR G9174_RS21995 ENOG4105C0H protease G9174_RS22000 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G9174_RS22005 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G9174_RS22010 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G9174_RS22015 ENOG4105EN6 Membrane G9174_RS22020 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G9174_RS22025 ENOG4105CMQ Chloride channel G9174_RS22030 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G9174_RS22035 ENOG4105S6R Iron-hydroxamate transporter permease subunit G9174_RS22040 ENOG4105J76 Periplasmic binding protein G9174_RS22045 ENOG4105E0A ABC, transporter G9174_RS22050 ENOG4105E0K tonB-dependent siderophore receptor G9174_RS22055 ENOG4105BZ4 penicillin-binding protein G9174_RS22150 ENOG4105CQ7 ATP-dependent helicase G9174_RS22155 ENOG4107XID 2'-5' rna ligase G9174_RS22160 ENOG4105PW4 Sugar fermentation stimulation protein homolog G9174_RS22165 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters G9174_RS22170 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G9174_RS22175 ENOG4105DJ0 Poly(A) Polymerase G9174_RS22180 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G9174_RS22185 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G9174_RS22190 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G9174_RS22195 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G9174_RS22200 ENOG4107BJW polysaccharide deacetylase G9174_RS22205 ENOG4108YTN IIa component G9174_RS22210 ENOG4105E3A (ABC) transporter G9174_RS22215 ENOG4105DA5 (ABC) transporter G9174_RS22220 ENOG41077A9 carbonic anhydrase G9174_RS22225 ENOG4108UGV hypoxanthine phosphoribosyltransferase G9174_RS22235 ENOG4105DZG Dehydrogenase G9174_RS22240 ENOG4105E3B Multicopper oxidase G9174_RS22245 ENOG4108ZRK uncharacterized protein yacC G9174_RS22270 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G9174_RS22275 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G9174_RS22280 ENOG4108ZIG UPF0231 protein G9174_RS22285 ENOG4107QIJ Aconitate hydratase 2 G9174_RS22290 ENOG4108NST exported protein G9174_RS22305 ENOG4107QN2 dihydrolipoyl dehydrogenase G9174_RS22310 ENOG4107QSN dihydrolipoamide acetyltransferase G9174_RS22315 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G9174_RS22320 ENOG41073TP transcriptional regulator G9174_RS22325 ENOG4105C85 amino acid G9174_RS22330 ENOG4105CT4 transporter G9174_RS22335 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) G9174_RS22340 ENOG4106A72 regulatory protein AmpE G9174_RS22345 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G9174_RS22350 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G9174_RS22355 ENOG4108ZUW Major pilin subunit G9174_RS22360 ENOG4107QHF type ii secretion system protein e G9174_RS22365 ENOG4105D7Q type ii secretion system G9174_RS22370 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G9174_RS22375 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G9174_RS22380 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) G9174_RS22385 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G9174_RS22390 ENOG4105M6F mutator MutT protein G9174_RS22395 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G9174_RS22400 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) G9174_RS22405 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G9174_RS22410 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G9174_RS22415 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G9174_RS22420 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G9174_RS22430 ENOG4105DFU Cell wall formation (By similarity) G9174_RS22435 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G9174_RS22440 ENOG4105CNI cell division protein FtsW G9174_RS22450 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G9174_RS22455 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G9174_RS22460 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G9174_RS22465 ENOG4105CJN penicillin-binding protein G9174_RS22470 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G9174_RS22475 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G9174_RS22485 ENOG4107B7Y DNA-binding transcriptional regulator FruR G9174_RS22490 ENOG4108ZP8 Acetolactate synthase small subunit G9174_RS22495 ENOG4105C7K acetolactate synthase G9174_RS22500 ENOG41064T2 transcriptional regulator, lysR family G9174_RS22510 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G9174_RS22520 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G9174_RS22525 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G9174_RS22540 ENOG4105EMV Major Facilitator G9174_RS22545 ENOG4105FF2 Type I DHQase G9174_RS22550 ENOG4105C5Q Transcriptional regulator G9174_RS22555 ENOG4105DJB Major Facilitator Superfamily G9174_RS22560 ENOG4105S8Q sugar efflux transporter G9174_RS22580 ENOG4106SMU thiamine transporter membrane protein G9174_RS22590 ENOG4108KF1 Membrane G9174_RS22595 ENOG41063TF transcriptional regulator (AraC G9174_RS22600 ENOG4105EF1 ribulokinase G9174_RS22605 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) G9174_RS22610 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G9174_RS22615 ENOG4105CQ2 DNA polymerase G9174_RS22620 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) G9174_RS22625 ENOG4105D3G Pseudouridine synthase G9174_RS22635 ENOG4105D2K citrate carrier protein G9174_RS22640 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G9174_RS22645 ENOG4106YYS transcriptional regulatory protein G9174_RS22650 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) G9174_RS22655 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G9174_RS22665 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G9174_RS22670 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G9174_RS22680 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G9174_RS22685 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G9174_RS22690 ENOG4105CKD glutathione-regulated potassium-efflux system protein G9174_RS22700 ENOG4105M5B (LipO)protein G9174_RS22705 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G9174_RS22710 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G9174_RS22715 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G9174_RS22720 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase G9174_RS22725 ENOG4105CHY citrate lyase, alpha G9174_RS22730 ENOG4105CI0 Citrate lyase G9174_RS22735 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) G9174_RS22740 ENOG4105DUA (citrate (pro-3S)-lyase ligase G9174_RS22745 ENOG4105D2K citrate carrier protein G9174_RS22755 ENOG4107QSA Oxaloacetate decarboxylase G9174_RS22760 ENOG4105D9Q decarboxylase (Beta subunit) G9174_RS22765 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G9174_RS22770 ENOG4106YYS transcriptional regulatory protein G9174_RS22775 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G9174_RS22780 ENOG4105EXG Transcriptional regulator G9174_RS22790 ENOG4105DU0 nucleoside hydrolase G9174_RS22795 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G9174_RS22800 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G9174_RS22805 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G9174_RS22815 ENOG4105DTN riboflavin biosynthesis protein ribF G9174_RS22825 ENOG41063Z6 transcriptional regulator, lysR family G9174_RS22830 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G9174_RS22835 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G9174_RS22840 ENOG4105CFG Acts as a chaperone (By similarity) G9174_RS22845 ENOG4108WTA UPF0412 protein YaaI G9174_RS22850 ENOG4108QUJ UPF0174 protein YaaW G9174_RS22855 ENOG4106HK8 GPR1 FUN34 yaaH family protein G9174_RS22860 ENOG4105CSH Transporter G9174_RS22865 ENOG4108RIR Molybdenum cofactor biosynthesis protein G9174_RS22870 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G9174_RS22875 ENOG4105BZG amino acid carrier protein G9174_RS22880 ENOG4105D1Q UPF0246 protein G9174_RS22890 ENOG4105D98 threonine synthase G9174_RS22895 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G9174_RS22900 ENOG4105CFH Aspartokinase G9174_RS22910 ENOG4106FVC RNA methyltransferase G9174_RS22915 ENOG410759A G9174_RS22920 ENOG41065U4 response regulator G9174_RS22925 ENOG4105CT7 inner membrane cred family protein G9174_RS22930 ENOG4105EB3 Histidine kinase G9174_RS22935 ENOG4105E3W Two component transcriptional regulator (Winged helix family G9174_RS22940 ENOG4108RH0 Crea protein G9174_RS22945 ENOG4105UEI Transcriptional Regulator AraC Family G9174_RS22950 ENOG4105CVJ phosphoglycerate mutase G9174_RS22955 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G9174_RS22960 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) G9174_RS22965 ENOG4107SC1 transglycosylase G9174_RS22970 ENOG4105C5H ABC transporter G9174_RS22975 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase G9174_RS22980 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G9174_RS22985 ENOG4105EAC phosphoserine phosphatase G9174_RS22990 ENOG41062Z9 Membrane G9174_RS22995 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) G9174_RS23010 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) G9174_RS23020 ENOG4105D9N nucleoside G9174_RS23025 ENOG4105EYA deoxyribonuclease G9174_RS23030 ENOG4108NRW Phospholipase, patatin family G9174_RS23035 ENOG41075IC Protein of unknown function (DUF1328) G9174_RS23040 ENOG4105K3G Periplasmic Protein G9174_RS23045 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G9174_RS23050 ENOG4105PAD Hydrolase G9174_RS23055 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G9174_RS23060 ENOG4108WPU DNA polymerase III subunit psi G9174_RS23065 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G9174_RS23085 ENOG4105YBH Protein of unknown function (DUF1435) G9174_RS23095 ENOG4106TD9 Diguanylate cyclase G9174_RS23100 ENOG4108819 ferric iron reductase G9174_RS23105 ENOG4105CK1 PTS System G9174_RS23110 ENOG4108UIN ybak prolyl-trna synthetase associated region G9174_RS23115 ENOG4108T94 DNA-binding transcriptional activator BglJ G9174_RS23120 ENOG4108N8T regulatoR G9174_RS23130 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G9174_RS23135 ENOG4105DWK Membrane G9174_RS23140 ENOG4107XM3 UPF0442 protein G9174_RS23145 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) G9174_RS23150 ENOG4106CVF DNA replication protein G9174_RS23155 ENOG4105RI1 glycoprotein receptor G9174_RS23165 ENOG4105DNE Transposase G9174_RS23180 ENOG4105F3R pts system mannose fructose sorbose family iid G9174_RS23185 ENOG4105ETZ PTS System G9174_RS23210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G9174_RS23215 ENOG4107QZW Altronate oxidoreductase G9174_RS23220 ENOG4105CPQ Dehydrogenase G9174_RS23230 ENOG4108I5G Major Facilitator superfamily G9174_RS23240 ENOG4105XYF acetyltransferase G9174_RS23245 ENOG4106KNT transcriptional regulator G9174_RS23250 ENOG4108RTU Aldolase G9174_RS23255 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 G9174_RS23285 ENOG4105DG4 malate L-lactate dehydrogenase G9174_RS23300 ENOG4108V8F Transcriptional regulator, MarR family G9174_RS23310 ENOG4105ERH Fumarylacetoacetate hydrolase G9174_RS23320 ENOG4105C26 Dehydrogenase G9174_RS23325 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase G9174_RS23340 ENOG4105CNV Aldolase G9174_RS23350 ENOG4108NKV transcriptional regulator G9174_RS23355 ENOG4105EFA 4-hydroxyphenylacetate G9174_RS23360 ENOG4107UWN reductase G9174_RS23375 ENOG4105D22 carbon starvation protein G9174_RS23380 ENOG4105VCD cytoplasmic protein G9174_RS23385 ENOG4105CKI cobalamin synthesis protein G9174_RS23395 ENOG4105C26 Dehydrogenase G9174_RS23400 ENOG4105DNE Transposase G9174_RS23405 ENOG4106AXJ AraC family transcriptional regulator G9174_RS23415 ENOG4106BRA Membrane G9174_RS23420 ENOG41083G8 Multidrug resistance protein MdtM G9174_RS23430 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase G9174_RS23435 ENOG4105CIZ coA-substrate-specific enzyme activase G9174_RS23450 ENOG4105EFX secretion protein, HlyD family G9174_RS23460 ENOG4106DIZ Domain of unknown function (DUF1127) G9174_RS23465 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9174_RS23475 ENOG41064T2 transcriptional regulator, lysR family G9174_RS23480 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G9174_RS23485 ENOG4105CNN ABC, transporter G9174_RS23490 ENOG4105CNN ABC, transporter G9174_RS23495 ENOG4105C2J ABC transporter G9174_RS23500 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9174_RS23510 ENOG4105D0S secretion protein (HlyD G9174_RS23515 ENOG4105CJ1 ABC, transporter G9174_RS23520 ENOG4105CMI transporter G9174_RS23550 ENOG4105EZE Cupin 4 family protein G9174_RS23565 ENOG4105GR3 Histidine kinase G9174_RS23570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9174_RS23575 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G9174_RS23580 ENOG410624V efflux system protein G9174_RS23585 ENOG4105EP1 Efflux transporter rnd family, mfp subunit G9174_RS23590 ENOG4108IJF Heavy metal efflux pump, CzcA G9174_RS23600 ENOG4105QNF Outer membrane lipoprotein G9174_RS23605 ENOG4108XDN Transcriptional regulator G9174_RS23615 ENOG4107FW0 short-chain dehydrogenase reductase G9174_RS23630 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G9174_RS23650 ENOG4107SEY Conserved Protein G9174_RS23655 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G9174_RS23660 ENOG4105C93 Xylose Isomerase G9174_RS23665 ENOG4105CT4 transporter G9174_RS23670 ENOG4105DSG hydrolase family 43 G9174_RS23735 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G9174_RS23745 ENOG4108YGG dna repair protein G9174_RS23750 ENOG4105MFG Antirestriction protein G9174_RS23755 ENOG4106H6R UPF0380 protein G9174_RS23770 ENOG4108PZQ Inner membrane protein YeeR G9174_RS23775 ENOG4105F4K antigen 43 G9174_RS23880 ENOG41077A9 carbonic anhydrase G9174_RS23885 ENOG4105CHH sulfate transporter G9174_RS23890 ENOG4105DQ4 alcohol dehydrogenase G9174_RS23900 ENOG4105DRS transport system, permease G9174_RS23905 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G9174_RS23910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9174_RS23915 ENOG4108IJG ABC transporter substrate-binding protein G9174_RS23920 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) G9174_RS23925 ENOG4105F0H myo-inositol catabolism protein G9174_RS23935 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G9174_RS23940 ENOG4105D7K pfkb domain protein G9174_RS23945 ENOG4105CHC glucokinase (EC 2.7.1.2) G9174_RS23950 ENOG4105DH8 myo-inositol catabolism G9174_RS23955 ENOG4105C26 Dehydrogenase G9174_RS23965 ENOG4105D7A ATP-binding protein G9174_RS23970 ENOG4108K5H permease YjgP YjgQ family protein G9174_RS23975 ENOG4108M8S permease YjgP YjgQ family protein G9174_RS23980 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G9174_RS23985 ENOG4105MYG DNA polymerase iii, chi subunit G9174_RS23990 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G9174_RS23995 ENOG4108MJ3 acetyltransferase G9174_RS24000 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase G9174_RS24005 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) G9174_RS24015 ENOG4105FDP GntR family transcriptional regulator G9174_RS24020 ENOG4105CSX c4-dicarboxylate anaerobic carrier G9174_RS24025 ENOG4105CI2 imidazolone-5-propionate hydrolase G9174_RS24030 ENOG4108KPW sugar kinase G9174_RS24035 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine G9174_RS24040 ENOG4105XEP YhcH YjgK YiaL family protein G9174_RS24050 ENOG4105CXT aspartate transcarbamylase G9174_RS24055 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) G9174_RS24060 ENOG4105KME endoribonuclease L-psp G9174_RS24070 ENOG4105D4X repressor G9174_RS24075 ENOG4105C5Y PTS System G9174_RS24080 ENOG4105CG3 alpha amylase, catalytic region G9174_RS24085 ENOG4105CK1 PTS System G9174_RS24090 ENOG4105F8D glycoside hydrolase family 4 G9174_RS24110 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase G9174_RS24115 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) G9174_RS24120 ENOG4105K4U addiction module toxin, RelE StbE family G9174_RS24130 ENOG4105EMD TRANSCRIPTIONal G9174_RS24135 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G9174_RS24150 ENOG41069H0 dihydroorotase EC 3.5.2.3 G9174_RS24185 ENOG4108XVM Cytochrome b(562) G9174_RS24190 ENOG4105CMS peptidase U62, modulator of DNA gyrase G9174_RS24195 ENOG4105N42 UPF0307 protein G9174_RS24220 ENOG4105DFU Cell wall formation (By similarity) G9174_RS24225 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 G9174_RS24230 ENOG41062B0 ABC transporter, permease G9174_RS24235 ENOG4107R9N ABC transporter G9174_RS24240 ENOG4105C2J ABC transporter G9174_RS24245 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator G9174_RS24250 ENOG4105F0N pyrophosphate phospho-hydrolase G9174_RS24265 ENOG4108ZHD aig2 family G9174_RS24270 ENOG4105MA0 exported protein G9174_RS24275 ENOG4105CFU surface antigen G9174_RS24285 ENOG4105C37 (CBS) domain G9174_RS24295 ENOG41061GZ Protein of unknown function (DUF1107) G9174_RS24300 ENOG4108UUE Transcriptional regulator G9174_RS24305 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase G9174_RS24310 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic G9174_RS24315 ENOG4105KVH Transcriptional regulator G9174_RS24320 ENOG4105ECR NmrA family G9174_RS24330 ENOG4105DXC membrane G9174_RS24335 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) G9174_RS24345 ENOG4108V1T peptidylprolyl cis-trans isomerase G9174_RS24350 ENOG4105FHY Opacity-associated protein A G9174_RS24355 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G9174_RS24360 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G9174_RS24365 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) G9174_RS24370 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) G9174_RS24375 ENOG4105KIT UPF0379 protein yjfY G9174_RS24400 ENOG4106ETB IIa component G9174_RS24410 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC G9174_RS24425 ENOG4108MXZ Esterase G9174_RS24430 ENOG4105WSB biofilm stress and motility protein A G9174_RS24435 ENOG4105S17 UPF0379 protein yjfN G9174_RS24440 ENOG4105CSU acyl-Coa dehydrogenase G9174_RS24445 ENOG4105C2N RNA methyltransferase TrmH family group 3 G9174_RS24450 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G9174_RS24455 ENOG4105KPV Transcriptional regulator G9174_RS24460 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G9174_RS24475 ENOG4105EPW hflc protein G9174_RS24480 ENOG4107QJR hflk protein G9174_RS24485 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G9174_RS24495 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G9174_RS24500 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G9174_RS24505 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G9174_RS24510 ENOG4105K8N protein family UPF0079, ATPase G9174_RS24515 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G9174_RS24520 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G9174_RS24540 ENOG4106TNF Periplasmic binding protein G9174_RS24545 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G9174_RS24550 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G9174_RS24555 ENOG4105DJ4 phosphatidylserine decarboxylase G9174_RS24560 ENOG4105EGS Mechanosensitive ion channel G9174_RS24565 ENOG4107SC7 Inner membrane transporter yjeM G9174_RS24570 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) G9174_RS24575 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G9174_RS24580 ENOG4105E33 succinate dehydrogenase G9174_RS24590 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) G9174_RS24600 ENOG4105KPY Small multidrug resistance protein G9174_RS24605 ENOG4106BSU Entericidin B G9174_RS24615 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G9174_RS24620 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G9174_RS24640 ENOG4105CW0 outer membrane usher protein G9174_RS24660 ENOG4108MBX Secretion Protein G9174_RS24665 ENOG4108JJA ABC, transporter G9174_RS24675 ENOG4108ZVF (LipO)protein G9174_RS24680 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G9174_RS24690 ENOG4105DVH amino acid G9174_RS24695 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 G9174_RS24700 ENOG4108IJ0 Aspartate ammonia-lyase G9174_RS24705 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G9174_RS24715 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G9174_RS24720 ENOG4108SIC Transcriptional regulator G9174_RS24750 ENOG4108TUY outer membrane protein PgaA G9174_RS24755 ENOG4107BJW polysaccharide deacetylase G9174_RS24760 ENOG4105CND Glycosyl transferase, family 2 G9174_RS24775 ENOG4108ZCF integral membrane protein G9174_RS24785 ENOG4105DVC DnaJ domain protein G9174_RS24815 ENOG4105CT4 transporter G9174_RS24820 ENOG4105F8D glycoside hydrolase family 4 G9174_RS24825 ENOG4108K2B transcriptional regulator G9174_RS24830 ENOG4105CSH Transporter G9174_RS24835 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G9174_RS24840 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase G9174_RS24845 ENOG4107RJJ Transcriptional regulator G9174_RS24850 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG G9174_RS24855 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH G9174_RS24860 ENOG4105EKV Phosphonate metabolism protein G9174_RS24865 ENOG4105FT8 Phosphonate metabolism G9174_RS24870 ENOG4105ENV phosphonate C-P lyase system protein PhnK G9174_RS24875 ENOG4105HRV phosphonate c-p lyase system protein phnl G9174_RS24880 ENOG4105FD8 phosphonate metabolism protein PhnM G9174_RS24885 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) G9174_RS24890 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein G9174_RS24900 ENOG4105BZU Histidine kinase G9174_RS24905 ENOG4105C2J ABC transporter G9174_RS24910 ENOG4105CNN ABC, transporter G9174_RS24915 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9174_RS24945 ENOG41082ND Uncharacterized protein yjcO G9174_RS24950 ENOG4105CK2 sodium dicarboxylate symporter G9174_RS24960 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G9174_RS24965 ENOG41062QD Membrane G9174_RS24970 ENOG4107QN1 sodium solute G9174_RS24985 ENOG4105CW0 outer membrane usher protein G9174_RS24990 ENOG4108VCD Chaperone G9174_RS24995 ENOG4105MX3 Fimbrial G9174_RS25000 ENOG41067MG lrgb family G9174_RS25010 ENOG4105CMU LysR family (Transcriptional regulator G9174_RS25015 ENOG4105EEQ Na H antiporter G9174_RS25020 ENOG4105C7N Xanthine uracil vitamin C permease G9174_RS25025 ENOG4108K3A Glutathione S-transferase G9174_RS25030 ENOG4108Z4X TRANSCRIPTIONal G9174_RS25035 ENOG4108W3Q Transcriptional regulator G9174_RS25040 ENOG4108M8H domain protein G9174_RS25045 ENOG4105PMV Membrane G9174_RS25070 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G9174_RS25075 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS25080 ENOG4105ECY inositol monophosphatase G9174_RS25090 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G9174_RS25105 ENOG4108DMH HTH_ARAC G9174_RS25110 ENOG4107RNH Outer membrane receptor FepA G9174_RS25115 ENOG4105E4C Lytic transglycosylase catalytic G9174_RS25120 ENOG4108UUM single-stranded DNA-binding protein G9174_RS25125 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G9174_RS25130 ENOG4105MSB protein, conserved in bacteria G9174_RS25135 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme G9174_RS25145 ENOG4105CGF Aromatic amino acid aminotransferase G9174_RS25150 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G9174_RS25155 ENOG4105CDU Replicative dna helicase G9174_RS25160 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G9174_RS25165 ENOG4105P4Z Phage shock protein G G9174_RS25170 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G9174_RS25180 ENOG4105MYN Zinc uptake regulation protein G9174_RS25185 ENOG4105VDW Csbd family G9174_RS25195 ENOG4107R73 Mate efflux family protein G9174_RS25200 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G9174_RS25205 ENOG41080IJ Diacylglycerol kinase G9174_RS25210 ENOG4105E55 glycerol-3-phosphate acyltransferase G9174_RS25215 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G9174_RS25220 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) G9174_RS25225 ENOG4107W52 maltose operon periplasmic protein G9174_RS25230 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) G9174_RS25235 ENOG4108IJ9 (ABC) transporter G9174_RS25240 ENOG4107FKK extracellular solute-binding protein family 1 G9174_RS25245 ENOG4105D56 permease protein G9174_RS25250 ENOG4105EG2 ABC transporter, permease G9174_RS25255 ENOG4108VY7 phosphate-starvation-inducible protein PsiE G9174_RS25260 ENOG4105CEM UPF0597 protein G9174_RS25275 ENOG4105KME endoribonuclease L-psp G9174_RS25285 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G9174_RS25290 ENOG4107QP8 phosphohexose isomerase G9174_RS25295 ENOG4105CFH Aspartokinase G9174_RS25300 ENOG4105C09 Bile acid G9174_RS25305 ENOG4108ZR5 Conserved Protein G9174_RS25310 ENOG4105FE9 pseudouridine synthase G9174_RS25315 ENOG4105DKT Transcriptional regulator G9174_RS25320 ENOG4105CHR reductase G9174_RS25325 ENOG4108XCU pts system G9174_RS25330 ENOG4105KPI PTS system sorbose subfamily IIB component G9174_RS25335 ENOG4105ETZ PTS System G9174_RS25340 ENOG4105F3R pts system mannose fructose sorbose family iid G9174_RS25345 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein G9174_RS25350 ENOG4105F9E Shikimate 5-dehydrogenase G9174_RS25355 ENOG4105EAM Na Pi-cotransporter G9174_RS25360 ENOG4105C3R Methionine synthase G9174_RS25365 ENOG41069M3 Transcriptional regulator G9174_RS25370 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) G9174_RS25375 ENOG4108I9X Isocitrate lyase G9174_RS25380 ENOG4107QP3 malate synthase g G9174_RS25385 ENOG4105CVG Homoserine O-transsuccinylase G9174_RS25390 ENOG4105K5X acetyltransferase G9174_RS25415 ENOG4105DC1 bifunctional purine biosynthesis protein purh G9174_RS25420 ENOG4105C12 Phosphoribosylglycinamide synthetase G9174_RS25430 ENOG4105BZU Histidine kinase G9174_RS25435 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism G9174_RS25440 ENOG4108T8B Protein of unknown function (DUF1481) G9174_RS25445 ENOG4105K70 DNA-binding protein G9174_RS25450 ENOG4105R2J Conserved Protein G9174_RS25455 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) G9174_RS25460 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G9174_RS25465 ENOG4105E09 nadh pyrophosphatase G9174_RS25470 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) G9174_RS25475 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G9174_RS25480 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G9174_RS25485 ENOG4105D06 uba thif-type nad fad binding protein G9174_RS25490 ENOG4105WHD thiamine biosynthesis protein ThiS G9174_RS25495 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G9174_RS25500 ENOG4105D41 biosynthesis protein thiH G9174_RS25505 ENOG4106TD9 Diguanylate cyclase G9174_RS25515 ENOG4105VCP PTS System G9174_RS25520 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G9174_RS25525 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G9174_RS25530 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G9174_RS25535 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G9174_RS25540 ENOG4108VZM 50s ribosomal protein L10 G9174_RS25545 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G9174_RS25550 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G9174_RS25555 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G9174_RS25560 ENOG4105PM1 preprotein translocase subunit SecE G9174_RS25565 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G9174_RS25590 ENOG4105CS9 pantothenic acid kinase G9174_RS25595 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G9174_RS25600 ENOG4105D4A Cell wall formation (By similarity) G9174_RS25630 ENOG4108RR8 protoporphyrinogen oxidase G9174_RS25635 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) G9174_RS25640 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G9174_RS25645 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) G9174_RS25650 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) G9174_RS25655 ENOG4105CHU acetyl-coa acetyltransferase G9174_RS25660 ENOG4107QK7 reductase G9174_RS25665 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G9174_RS25670 ENOG4105MDZ Transcriptional activator rfaH G9174_RS25680 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G9174_RS25685 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G9174_RS25690 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G9174_RS25695 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) G9174_RS25700 ENOG4105JC1 sterol-binding domain protein G9174_RS25705 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9174_RS25710 ENOG4105CGY Dna recombination protein G9174_RS25715 ENOG4107SXA Phosphorylase G9174_RS25720 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) G9174_RS25725 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G9174_RS25730 ENOG4105DZ2 Transcriptional regulator G9174_RS25735 ENOG4105EMK carboxylate amino acid amine transporter G9174_RS25740 ENOG4105DQF Hydrolase G9174_RS25745 ENOG4108EUD Lysophospholipase G9174_RS25750 ENOG410829K Lysine exporter protein (Lyse ygga) G9174_RS25760 ENOG4105CCF Lysine exporter protein (Lyse ygga) G9174_RS25765 ENOG4105C9U ATP-dependent DNA helicase RecQ G9174_RS25770 ENOG4105HDD phospholipase G9174_RS25775 ENOG4108VUY thioesterase Superfamily protein G9174_RS25780 ENOG4105FR1 rard protein G9174_RS25785 ENOG4107QUT magnesium and cobalt transport protein CorA G9174_RS25790 ENOG4105C4R Atp-dependent dna helicase G9174_RS25795 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant G9174_RS25800 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G9174_RS25805 ENOG4105CT0 Protein of unknown function, DUF484 G9174_RS25815 ENOG4105S7Z (LipO)protein G9174_RS25820 ENOG4105XQ6 frataxin-like protein G9174_RS25825 ENOG4107T0K Adenylate cyclase G9174_RS25830 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G9174_RS25835 ENOG41076E6 Uroporphyrinogen-III Synthase G9174_RS25840 ENOG4105ECF c-methyltransferase G9174_RS25845 ENOG410601J HemY protein G9174_RS25870 ENOG4105C85 amino acid G9174_RS25875 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family G9174_RS25880 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) G9174_RS25885 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) G9174_RS25890 ENOG4105EGZ biosynthesis protein G9174_RS25895 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G9174_RS25900 ENOG4108WJ1 acetyltransferase G9174_RS25905 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G9174_RS25910 ENOG4105C1B dTDP-glucose 4-6-dehydratase G9174_RS25915 ENOG4107QQG Dehydrogenase G9174_RS25920 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G9174_RS25925 ENOG4105SFE lipopolysaccharide biosynthesis protein G9174_RS25930 ENOG4105ESV Glycosyl transferase, family 4 G9174_RS25935 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G9174_RS25945 ENOG4105C1J atp-dependent rna helicase G9174_RS25950 ENOG4105C9X ppx gppa phosphatase G9174_RS25965 ENOG4108UQV Membrane G9174_RS25970 ENOG4105C4R Atp-dependent dna helicase G9174_RS25975 ENOG4105KQ5 peptidylprolyl cis-trans isomerase G9174_RS25980 ENOG4105KQ5 peptidylprolyl cis-trans isomerase G9174_RS25985 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G9174_RS25990 ENOG4105EMY transcriptional regulator G9174_RS25995 ENOG4105C7B Threonine dehydratase G9174_RS26000 ENOG4105C01 Dihydroxy-acid dehydratase G9174_RS26005 ENOG4105CM2 brancheD-chain amino acid aminotransferase G9174_RS26010 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit G9174_RS26025 ENOG4105C0P Mg chelatase subunit ChlI G9174_RS26030 ENOG4108WFC UPF0438 protein yifE G9174_RS26085 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) G9174_RS26090 ENOG4108Y73 Membrane G9174_RS26095 ENOG4105EJ2 Transcriptional regulator G9174_RS26100 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) G9174_RS26105 ENOG4105C5Q Transcriptional regulator G9174_RS26110 ENOG4105CH7 arginosuccinase G9174_RS26115 ENOG4105CAS nag kinase G9174_RS26120 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G9174_RS26135 ENOG4108MEK Metal-binding protein YodA G9174_RS26140 ENOG4106R3P AraC family transcriptional regulator G9174_RS26145 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G9174_RS26150 ENOG4105DCT glycerol dehydrogenase G9174_RS26155 ENOG4108Q5Y Membrane G9174_RS26160 ENOG4105SYT Methylenetetrahydrofolate reductase G9174_RS26165 ENOG4105CN8 Transcriptional regulator G9174_RS26170 ENOG4108Z8I decarboxylase G9174_RS26175 ENOG4105CGH 5'-nucleotidase G9174_RS26185 ENOG4105CFH Aspartokinase G9174_RS26190 ENOG4105C28 cystathionine G9174_RS26195 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) G9174_RS26200 ENOG4105VFB Binds the 23S rRNA (By similarity) G9174_RS26205 ENOG4105C25 Primosomal protein n' G9174_RS26210 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS26215 ENOG41063M6 Cell Division Protein G9174_RS26220 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G9174_RS26230 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase G9174_RS26235 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G9174_RS26240 ENOG4105CTQ phosphohexokinase G9174_RS26245 ENOG41076HS cation diffusion facilitator family transporter G9174_RS26250 ENOG4105FMW periplasmic G9174_RS26255 ENOG4105E3W Two component transcriptional regulator (Winged helix family G9174_RS26260 ENOG4105E0F Histidine kinase G9174_RS26265 ENOG4108RPX mosc domain containing protein G9174_RS26270 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G9174_RS26275 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) G9174_RS26280 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) G9174_RS26285 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) G9174_RS26290 ENOG4105DET Rhamnulokinase G9174_RS26295 ENOG4105DKG l-rhamnose isomerase G9174_RS26300 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) G9174_RS26305 ENOG4105D4B ABC, transporter G9174_RS26310 ENOG4105C2J ABC transporter G9174_RS26315 ENOG4105CNN ABC, transporter G9174_RS26320 ENOG4105CNN ABC, transporter G9174_RS26325 ENOG4105C0A alcohol dehydrogenase G9174_RS26335 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G9174_RS26380 ENOG4105D2N Aldolase G9174_RS26395 ENOG4105CTQ phosphohexokinase G9174_RS26405 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G9174_RS26415 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G9174_RS26420 ENOG4108MG3 formate dehydrogenase G9174_RS26425 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) G9174_RS26435 ENOG41068KX affects formate dehydrogenase-N G9174_RS26445 ENOG4105SUU thioesterase domain G9174_RS26450 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G9174_RS26455 ENOG4107S2Z UPF0761 membrane protein G9174_RS26460 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 G9174_RS26465 ENOG4105CI3 gtp-binding protein typa G9174_RS26470 ENOG4105C5F glutamine synthetase G9174_RS26475 ENOG4105CUX Signal transduction histidine kinase G9174_RS26480 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G9174_RS26485 ENOG4106FIY G9174_RS26490 ENOG4105D4P Coproporphyrinogen iii oxidase G9174_RS26495 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) G9174_RS26500 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) G9174_RS26505 ENOG4105C2M dna polymerase I G9174_RS26510 ENOG4106HNH Acyl-transferase G9174_RS26515 ENOG4108Z33 Thiol disulfide Interchange Protein G9174_RS26520 ENOG4105E27 serine threonine protein kinase G9174_RS26525 ENOG4105PC1 Conserved Protein G9174_RS26530 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G9174_RS26535 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b G9174_RS26560 ENOG4107EJG GntR family transcriptional regulator G9174_RS26565 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9174_RS26570 ENOG4105ETE Transcriptional regulator (LacI family G9174_RS26575 ENOG4108RVA ribokinase G9174_RS26580 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9174_RS26585 ENOG4105CNN ABC, transporter G9174_RS26590 ENOG4105C2J ABC transporter G9174_RS26600 ENOG4105DFH Transport of potassium into the cell (By similarity) G9174_RS26615 ENOG4105CU9 asparagine synthetase A G9174_RS26620 ENOG4108VVK transcriptional Regulator, AsnC G9174_RS26625 ENOG4105QTB Flavodoxin G9174_RS26630 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G9174_RS26635 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G9174_RS26640 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation G9174_RS26660 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G9174_RS26665 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G9174_RS26670 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G9174_RS26675 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G9174_RS26680 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G9174_RS26685 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G9174_RS26690 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G9174_RS26695 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G9174_RS26705 ENOG4105C8U phosphate abc transporter G9174_RS26710 ENOG4105E2Z phosphate ABC transporter (Permease G9174_RS26715 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G9174_RS26730 ENOG4105DYC esterase G9174_RS26735 ENOG4107VKM 6-phosphogluconolactonase G9174_RS26740 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 G9174_RS26745 ENOG4105C7N Xanthine uracil vitamin C permease G9174_RS26750 ENOG4108YYH Nadph-dependent fmn reductase G9174_RS26755 ENOG4105E8Q phosphopantetheinyl transferase G9174_RS26765 ENOG4105C2C drug resistance transporter, Bcr CflA G9174_RS26775 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G9174_RS26780 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G9174_RS26785 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G9174_RS26795 ENOG4105VG0 50S ribosomal protein l34 G9174_RS26850 ENOG4105HEI LysR family (Transcriptional regulator G9174_RS27000 ENOG4108XS9 dna repair protein G9174_RS27040 ENOG4105KF5 hemolysin expression-modulating protein G9174_RS27075 ENOG4108UUM single-stranded DNA-binding protein G9174_RS27295 ENOG4105EKQ RNA-directed DNA polymerase G9174_RS27360 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A G9174_RS27385 ENOG4108BUD transposase G9174_RS27405 ENOG4108BUD transposase G9174_RS27415 ENOG4105VUN Transcriptional regulator