locus-tag class description GTH21_RS00030 ENOG4105CMI transporter GTH21_RS00035 ENOG4105CJ1 ABC, transporter GTH21_RS00040 ENOG4105D0S secretion protein (HlyD GTH21_RS00045 ENOG4105BZU Histidine kinase GTH21_RS00070 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) GTH21_RS00075 ENOG4105KNY Microcompartments protein GTH21_RS00080 ENOG4105F1A Pyruvate formate-lyase GTH21_RS00085 ENOG4105C6N Formate acetyltransferase GTH21_RS00100 ENOG4105C0A alcohol dehydrogenase GTH21_RS00105 ENOG4105KNY Microcompartments protein GTH21_RS00110 ENOG4105KNY Microcompartments protein GTH21_RS00115 ENOG4105KNY Microcompartments protein GTH21_RS00135 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GTH21_RS00140 ENOG41064T2 transcriptional regulator, lysR family GTH21_RS00155 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GTH21_RS00160 ENOG4106DIZ Domain of unknown function (DUF1127) GTH21_RS00170 ENOG4105EFX secretion protein, HlyD family GTH21_RS00185 ENOG4105CIZ coA-substrate-specific enzyme activase GTH21_RS00190 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GTH21_RS00200 ENOG41083G8 Multidrug resistance protein MdtM GTH21_RS00205 ENOG4106BRA Membrane GTH21_RS00220 ENOG4105DNE Transposase GTH21_RS00225 ENOG4105C26 Dehydrogenase GTH21_RS00235 ENOG4105CKI cobalamin synthesis protein GTH21_RS00240 ENOG4105VCD cytoplasmic protein GTH21_RS00245 ENOG4105D22 carbon starvation protein GTH21_RS00250 ENOG4107UWN reductase GTH21_RS00255 ENOG4105EFA 4-hydroxyphenylacetate GTH21_RS00260 ENOG4108NKV transcriptional regulator GTH21_RS00270 ENOG4105CNV Aldolase GTH21_RS00285 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase GTH21_RS00320 ENOG4105ERH Fumarylacetoacetate hydrolase GTH21_RS00330 ENOG4108V8F Transcriptional regulator, MarR family GTH21_RS00345 ENOG4105DG4 malate L-lactate dehydrogenase GTH21_RS00375 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GTH21_RS00380 ENOG4108RTU Aldolase GTH21_RS00385 ENOG4106KNT transcriptional regulator GTH21_RS00390 ENOG4105XYF acetyltransferase GTH21_RS00400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GTH21_RS00410 ENOG4105KPI PTS system sorbose subfamily IIB component GTH21_RS00415 ENOG4105ETZ PTS System GTH21_RS00420 ENOG4105F3R pts system mannose fructose sorbose family iid GTH21_RS00435 ENOG4105DNE Transposase GTH21_RS00445 ENOG4105RI1 glycoprotein receptor GTH21_RS00450 ENOG4106CVF DNA replication protein GTH21_RS00455 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) GTH21_RS00460 ENOG4107XM3 UPF0442 protein GTH21_RS00465 ENOG4105DWK Membrane GTH21_RS00470 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase GTH21_RS00480 ENOG4108N8T regulatoR GTH21_RS00485 ENOG4108T94 DNA-binding transcriptional activator BglJ GTH21_RS00490 ENOG4108UIN ybak prolyl-trna synthetase associated region GTH21_RS00495 ENOG4105CK1 PTS System GTH21_RS00500 ENOG4108819 ferric iron reductase GTH21_RS00505 ENOG4106TD9 Diguanylate cyclase GTH21_RS00515 ENOG4105YBH Protein of unknown function (DUF1435) GTH21_RS00535 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GTH21_RS00540 ENOG4108WPU DNA polymerase III subunit psi GTH21_RS00545 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GTH21_RS00550 ENOG4105PAD Hydrolase GTH21_RS00555 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GTH21_RS00560 ENOG4105K3G Periplasmic Protein GTH21_RS00565 ENOG41075IC Protein of unknown function (DUF1328) GTH21_RS00570 ENOG4108NRW Phospholipase, patatin family GTH21_RS00575 ENOG4105EYA deoxyribonuclease GTH21_RS00580 ENOG4105D9N nucleoside GTH21_RS00590 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GTH21_RS00605 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GTH21_RS00610 ENOG41062Z9 Membrane GTH21_RS00615 ENOG4105EAC phosphoserine phosphatase GTH21_RS00620 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GTH21_RS00625 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase GTH21_RS00630 ENOG4105C5H ABC transporter GTH21_RS00635 ENOG4107SC1 transglycosylase GTH21_RS00640 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GTH21_RS00645 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GTH21_RS00650 ENOG4105CVJ phosphoglycerate mutase GTH21_RS00655 ENOG4105UEI Transcriptional Regulator AraC Family GTH21_RS00660 ENOG4108RH0 Crea protein GTH21_RS00665 ENOG4105E3W Two component transcriptional regulator (Winged helix family GTH21_RS00670 ENOG4105EB3 Histidine kinase GTH21_RS00675 ENOG4105CT7 inner membrane cred family protein GTH21_RS00680 ENOG41065U4 response regulator GTH21_RS00685 ENOG410759A GTH21_RS00690 ENOG4106FVC RNA methyltransferase GTH21_RS00705 ENOG4105CFH Aspartokinase GTH21_RS00710 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GTH21_RS00715 ENOG4105D98 threonine synthase GTH21_RS00725 ENOG4105D1Q UPF0246 protein GTH21_RS00730 ENOG4105BZG amino acid carrier protein GTH21_RS00735 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GTH21_RS00740 ENOG4108RIR Molybdenum cofactor biosynthesis protein GTH21_RS00745 ENOG4105CSH Transporter GTH21_RS00750 ENOG4106HK8 GPR1 FUN34 yaaH family protein GTH21_RS00755 ENOG4108QUJ UPF0174 protein YaaW GTH21_RS00760 ENOG4108WTA UPF0412 protein YaaI GTH21_RS00765 ENOG4105CFG Acts as a chaperone (By similarity) GTH21_RS00770 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GTH21_RS00775 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GTH21_RS00780 ENOG41063Z6 transcriptional regulator, lysR family GTH21_RS00800 ENOG4105DTN riboflavin biosynthesis protein ribF GTH21_RS00810 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GTH21_RS00815 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GTH21_RS00820 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GTH21_RS00825 ENOG4105DU0 nucleoside hydrolase GTH21_RS00835 ENOG4105EXG Transcriptional regulator GTH21_RS00840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GTH21_RS00845 ENOG4106YYS transcriptional regulatory protein GTH21_RS00850 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GTH21_RS00855 ENOG4105D9Q decarboxylase (Beta subunit) GTH21_RS00860 ENOG4107QSA Oxaloacetate decarboxylase GTH21_RS00870 ENOG4105D2K citrate carrier protein GTH21_RS00875 ENOG4105DUA (citrate (pro-3S)-lyase ligase GTH21_RS00880 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) GTH21_RS00885 ENOG4105CI0 Citrate lyase GTH21_RS00890 ENOG4105CHY citrate lyase, alpha GTH21_RS00895 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GTH21_RS00900 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GTH21_RS00910 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GTH21_RS00915 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GTH21_RS00920 ENOG4105M5B (LipO)protein GTH21_RS00930 ENOG4105CKD glutathione-regulated potassium-efflux system protein GTH21_RS00935 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GTH21_RS00940 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GTH21_RS00950 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GTH21_RS00955 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GTH21_RS00965 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GTH21_RS00970 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GTH21_RS00975 ENOG4106YYS transcriptional regulatory protein GTH21_RS00980 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GTH21_RS00985 ENOG4105D2K citrate carrier protein GTH21_RS00995 ENOG4105D3G Pseudouridine synthase GTH21_RS01000 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GTH21_RS01005 ENOG4105CQ2 DNA polymerase GTH21_RS01010 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GTH21_RS01015 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GTH21_RS01020 ENOG4105EF1 ribulokinase GTH21_RS01030 ENOG41063TF transcriptional regulator (AraC GTH21_RS01035 ENOG4108KF1 Membrane GTH21_RS01045 ENOG4106SMU thiamine transporter membrane protein GTH21_RS01070 ENOG4105S8Q sugar efflux transporter GTH21_RS01075 ENOG4105DJB Major Facilitator Superfamily GTH21_RS01080 ENOG4105C5Q Transcriptional regulator GTH21_RS01085 ENOG4105FF2 Type I DHQase GTH21_RS01090 ENOG4105EMV Major Facilitator GTH21_RS01105 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GTH21_RS01110 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GTH21_RS01120 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GTH21_RS01135 ENOG41064T2 transcriptional regulator, lysR family GTH21_RS01140 ENOG4105C7K acetolactate synthase GTH21_RS01145 ENOG4108ZP8 Acetolactate synthase small subunit GTH21_RS01150 ENOG4107B7Y DNA-binding transcriptional regulator FruR GTH21_RS01160 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GTH21_RS01165 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GTH21_RS01170 ENOG4105CJN penicillin-binding protein GTH21_RS01175 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GTH21_RS01180 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GTH21_RS01185 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GTH21_RS01195 ENOG4105CNI cell division protein FtsW GTH21_RS01200 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GTH21_RS01205 ENOG4105DFU Cell wall formation (By similarity) GTH21_RS01215 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GTH21_RS01220 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GTH21_RS01225 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GTH21_RS01230 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GTH21_RS01235 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) GTH21_RS01240 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GTH21_RS01245 ENOG4105M6F mutator MutT protein GTH21_RS01250 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GTH21_RS01255 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GTH21_RS01260 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GTH21_RS01265 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GTH21_RS01270 ENOG4105D7Q type ii secretion system GTH21_RS01275 ENOG4107QHF type ii secretion system protein e GTH21_RS01280 ENOG4108ZUW Major pilin subunit GTH21_RS01285 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GTH21_RS01290 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GTH21_RS01295 ENOG4106A72 regulatory protein AmpE GTH21_RS01300 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GTH21_RS01305 ENOG4105CT4 transporter GTH21_RS01310 ENOG4105C85 amino acid GTH21_RS01315 ENOG41073TP transcriptional regulator GTH21_RS01320 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GTH21_RS01325 ENOG4107QSN dihydrolipoamide acetyltransferase GTH21_RS01330 ENOG4107QN2 dihydrolipoyl dehydrogenase GTH21_RS01345 ENOG4108NST exported protein GTH21_RS01355 ENOG4107QIJ Aconitate hydratase 2 GTH21_RS01360 ENOG4108ZIG UPF0231 protein GTH21_RS01365 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GTH21_RS01370 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GTH21_RS01395 ENOG4108ZRK uncharacterized protein yacC GTH21_RS01400 ENOG4105E3B Multicopper oxidase GTH21_RS01405 ENOG4105DZG Dehydrogenase GTH21_RS01415 ENOG4108UGV hypoxanthine phosphoribosyltransferase GTH21_RS01420 ENOG41077A9 carbonic anhydrase GTH21_RS01425 ENOG4105DA5 (ABC) transporter GTH21_RS01430 ENOG4105E3A (ABC) transporter GTH21_RS01435 ENOG4108YTN IIa component GTH21_RS01440 ENOG4107BJW polysaccharide deacetylase GTH21_RS01445 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GTH21_RS01450 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GTH21_RS01455 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GTH21_RS01460 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GTH21_RS01465 ENOG4105DJ0 Poly(A) Polymerase GTH21_RS01470 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GTH21_RS01475 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GTH21_RS01480 ENOG4105PW4 Sugar fermentation stimulation protein homolog GTH21_RS01485 ENOG4107XID 2'-5' rna ligase GTH21_RS01490 ENOG4105CQ7 ATP-dependent helicase GTH21_RS01585 ENOG4105BZ4 penicillin-binding protein GTH21_RS01590 ENOG4105E0K tonB-dependent siderophore receptor GTH21_RS01595 ENOG4105E0A ABC, transporter GTH21_RS01600 ENOG4105J76 Periplasmic binding protein GTH21_RS01605 ENOG4105S6R Iron-hydroxamate transporter permease subunit GTH21_RS01610 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GTH21_RS01615 ENOG4105CMQ Chloride channel GTH21_RS01620 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GTH21_RS01625 ENOG4105EN6 Membrane GTH21_RS01630 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GTH21_RS01635 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GTH21_RS01640 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GTH21_RS01645 ENOG4105C0H protease GTH21_RS01650 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GTH21_RS01655 ENOG4108T8E UPF0325 protein GTH21_RS01660 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GTH21_RS01665 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GTH21_RS01670 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GTH21_RS01675 ENOG4105CE9 30S ribosomal protein S2 GTH21_RS01680 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GTH21_RS01685 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GTH21_RS01695 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GTH21_RS01705 ENOG4105KNE Phosphatidate cytidylyltransferase GTH21_RS01710 ENOG4105DZP Membrane-associated zinc metalloprotease GTH21_RS01720 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GTH21_RS01725 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GTH21_RS01730 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GTH21_RS01735 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GTH21_RS01740 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GTH21_RS01745 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GTH21_RS01750 ENOG4105C0B DNA polymerase III (alpha subunit) GTH21_RS01755 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GTH21_RS01760 ENOG4105CXN decarboxylase GTH21_RS01765 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GTH21_RS01770 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GTH21_RS01775 ENOG4105M1T rho-binding antiterminator GTH21_RS01780 ENOG4105W1I UPF0253 protein GTH21_RS01785 ENOG4108VWS Yaeq family GTH21_RS01790 ENOG4108YZN class I peptide chain release factor GTH21_RS01795 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GTH21_RS01800 ENOG4108UY0 (LipO)protein GTH21_RS01805 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GTH21_RS01810 ENOG4108R96 Methyltransferase, YaeB family GTH21_RS01815 ENOG4108R8X outer membrane lipoprotein GTH21_RS01820 ENOG4105D01 (LipO)protein GTH21_RS01825 ENOG4108UMI ABC transporter, permease GTH21_RS01830 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS01835 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GTH21_RS01870 ENOG4105CV8 reductase GTH21_RS01875 ENOG4105HEI LysR family (Transcriptional regulator GTH21_RS01880 ENOG4105F27 Major Facilitator GTH21_RS01890 ENOG4105F2W methyltransferase GTH21_RS01895 ENOG4105E9H Lytic Murein transglycosylase GTH21_RS01900 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GTH21_RS01905 ENOG4105D1A Methyltransferase GTH21_RS01910 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GTH21_RS01915 ENOG4107RZZ dna polymerase iii epsilon subunit GTH21_RS01925 ENOG41090KR LysR family transcriptional Regulator GTH21_RS01930 ENOG4108VP3 Lysine exporter protein (LysE YggA) GTH21_RS01935 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GTH21_RS01940 ENOG4107QPN acyl-Coa dehydrogenase GTH21_RS01945 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GTH21_RS01950 ENOG4105E7A Glutamine amidotransferase GTH21_RS01955 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GTH21_RS01960 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GTH21_RS01965 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GTH21_RS01970 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GTH21_RS01975 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GTH21_RS01980 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GTH21_RS01985 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GTH21_RS02000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GTH21_RS02005 ENOG4108HYG acetyltransferase GTH21_RS02010 ENOG4105CIN aminoacyl-histidine dipeptidase GTH21_RS02015 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GTH21_RS02020 ENOG4105V1F Fermentation respiration switch protein GTH21_RS02025 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GTH21_RS02030 ENOG4108PVQ transcriptional regulator GTH21_RS02040 ENOG4108JPW Aminotransferase GTH21_RS02045 ENOG4105C26 Dehydrogenase GTH21_RS02050 ENOG4105D5U fad dependent oxidoreductase GTH21_RS02060 ENOG4105YCT UPF0386 protein GTH21_RS02065 ENOG4105DTA methyltransferase GTH21_RS02070 ENOG4108TGY Glutathione S-transferase GTH21_RS02075 ENOG4105DT3 PTS system, galactitol-specific IIc component GTH21_RS02080 ENOG4108JQ1 Dehydrogenase GTH21_RS02085 ENOG4105CHR reductase GTH21_RS02090 ENOG4105CMG Carbohydrate kinase GTH21_RS02100 ENOG41061GT Aldolase GTH21_RS02120 ENOG4105CPP Dehydrogenase, E1 component GTH21_RS02125 ENOG4107R0V Pyruvate dehydrogenase GTH21_RS02180 ENOG4105ZTC transcriptional activator, Ogr delta GTH21_RS02200 ENOG4107QJE Chromosome Partitioning Protein GTH21_RS02205 ENOG4105DFP Integrase GTH21_RS02215 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GTH21_RS02220 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GTH21_RS02225 ENOG4105FCK Membrane GTH21_RS02230 ENOG4108QBX (LipO)protein GTH21_RS02250 ENOG4105S7S phosphonate abc transporter GTH21_RS02260 ENOG4105EHI Phosphonate ABC transporter, periplasmic GTH21_RS02270 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon GTH21_RS02275 ENOG4108GWT fimbrillin MatB GTH21_RS02280 ENOG4108NN8 Fimbrial protein GTH21_RS02285 ENOG4108N3D putative enzyme GTH21_RS02290 ENOG4106PYX Receptor GTH21_RS02300 ENOG4105DRP amino acid AbC transporter GTH21_RS02305 ENOG4105E5Q amino acid AbC transporter GTH21_RS02310 ENOG4105CDA abc transporter atp-binding protein GTH21_RS02315 ENOG4105CT1 (ABC) transporter GTH21_RS02325 ENOG4108IV0 ABC, transporter GTH21_RS02330 ENOG4105C0Z ABC transporter GTH21_RS02335 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GTH21_RS02340 ENOG4105C32 Amino acid ABC transporter (Permease) GTH21_RS02355 ENOG4107FQ9 ethanolamine ammonia-lyase GTH21_RS02360 ENOG4105CPD ethanolamine ammonia-lyase GTH21_RS02365 ENOG4105C85 amino acid GTH21_RS02375 ENOG4108IQI permease GTH21_RS02380 ENOG4107QK5 Homocysteine s-methyltransferase GTH21_RS02385 ENOG4106FTQ Taurine ABC transporter, periplasmic GTH21_RS02390 ENOG4108ETV ABC transporter GTH21_RS02395 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GTH21_RS02400 ENOG4105E2B Taurine dioxygenase GTH21_RS02410 ENOG4108UK5 Transposase GTH21_RS02415 ENOG4105D52 delta-aminolevulinic acid dehydratase GTH21_RS02420 ENOG4107R6D beta-lactam binding protein AmpH GTH21_RS02425 ENOG4108RWI nicotinamidase GTH21_RS02430 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 GTH21_RS02435 ENOG4107QS8 (LipO)protein GTH21_RS02440 ENOG4105FR5 inner membrane protein YaiY GTH21_RS02445 ENOG4105UNH Membrane GTH21_RS02450 ENOG4105CPF Cell wall formation (By similarity) GTH21_RS02470 ENOG4105G6Z alkaline phosphatase GTH21_RS02475 ENOG4105VIF phosphate starvation-inducible protein GTH21_RS02480 ENOG4105II7 pyrroline-5-carboxylate reductase GTH21_RS02485 ENOG4108UPT UPF0178 protein GTH21_RS02490 ENOG4105G4C Periplasmic ligand-binding sensor protein GTH21_RS02495 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GTH21_RS02500 ENOG4105SS3 GTH21_RS02505 ENOG4105HBA AroM protein GTH21_RS02510 ENOG4105NBK UPF0345 protein GTH21_RS02515 ENOG4105DH7 May be involved in recombination (By similarity) GTH21_RS02520 ENOG4105DKQ ROK family GTH21_RS02525 ENOG4105EYH Exonuclease GTH21_RS02530 ENOG4107RH8 nuclease SbcCD subunit D GTH21_RS02535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GTH21_RS02540 ENOG4105BZU Histidine kinase GTH21_RS02545 ENOG4105CWM branched-chain amino acid transport system II carrier protein GTH21_RS02550 ENOG4105C85 amino acid GTH21_RS02555 ENOG4107R28 alpha amylase, catalytic region GTH21_RS02560 ENOG4105EQ1 Transcriptional regulator GTH21_RS02565 ENOG4105CHJ isochorismatase hydrolase GTH21_RS02575 ENOG4105CI2 imidazolone-5-propionate hydrolase GTH21_RS02585 ENOG4108MGF sugar kinase GTH21_RS02600 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GTH21_RS02610 ENOG4105D3R alkyl hydroperoxide reductase GTH21_RS02615 ENOG4108ZYK Acyl carrier protein phosphodiesterase GTH21_RS02625 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GTH21_RS02630 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GTH21_RS02635 ENOG4105VIE preprotein translocase, subunit YajC GTH21_RS02640 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GTH21_RS02645 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GTH21_RS02660 ENOG4105DRB nucleoside-specific channel-forming protein GTH21_RS02665 ENOG4108KIC (LipO)protein GTH21_RS02670 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GTH21_RS02675 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GTH21_RS02680 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GTH21_RS02685 ENOG4107YIM Involved in the transcription termination process (By similarity) GTH21_RS02690 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GTH21_RS02695 ENOG4108ZAI phosphatidylglycerophosphatase a GTH21_RS02700 ENOG4105CPC Aldo Keto reductase GTH21_RS02705 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GTH21_RS02710 ENOG4105CTB Polyprenyl synthetase GTH21_RS02715 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GTH21_RS02720 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GTH21_RS02730 ENOG4107S0N DJ-1 family GTH21_RS02735 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GTH21_RS02745 ENOG4107RDB Major Facilitator GTH21_RS02750 ENOG4105CIB oxidoreductase Domain protein GTH21_RS02755 ENOG4105D2S major facilitator superfamily GTH21_RS02765 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein GTH21_RS02775 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein GTH21_RS02780 ENOG4105E2X shikimate dehydrogenase GTH21_RS02785 ENOG4107HP6 Transcriptional regulator GTH21_RS02795 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GTH21_RS02800 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GTH21_RS02805 ENOG4105CCU oxidase (Subunit III) GTH21_RS02810 ENOG4105BZ9 Cytochrome C oxidase, subunit I GTH21_RS02815 ENOG4105E2S oxidase) subunit II GTH21_RS02820 ENOG4105EYM Major Facilitator superfamily GTH21_RS02825 ENOG4105IEY (LipO)protein GTH21_RS02830 ENOG4105M85 Bola protein GTH21_RS02840 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GTH21_RS02850 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GTH21_RS02855 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GTH21_RS02860 ENOG4105K70 DNA-binding protein GTH21_RS02865 ENOG4105EIN peptidylprolyl cis-trans isomerase GTH21_RS02870 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GTH21_RS02875 ENOG4108TGP Thioesterase superfamily protein GTH21_RS02880 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GTH21_RS02885 ENOG4108NFA extracellular solute-binding protein GTH21_RS02890 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) GTH21_RS02900 ENOG4108XM1 transcriptional regulator AsnC family GTH21_RS02905 ENOG4105BZ1 (ABC) transporter GTH21_RS02910 ENOG4105BZ1 (ABC) transporter GTH21_RS02915 ENOG4108YZA Nitrogen regulatory protein pii GTH21_RS02920 ENOG4105BZU Histidine kinase GTH21_RS02925 ENOG4105C29 acyl-CoA thioesterase GTH21_RS02930 ENOG4108MNP Glycoprotein polysaccharide metabolism GTH21_RS02935 ENOG41080UX Methyltransferase GTH21_RS02965 ENOG4108VW9 Membrane GTH21_RS02970 ENOG41061MD high-affinity nickel-transporter GTH21_RS02975 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter GTH21_RS02980 ENOG41066DG (EAL) domain protein GTH21_RS02995 ENOG4107FKK extracellular solute-binding protein family 1 GTH21_RS03005 ENOG4105EG2 ABC transporter, permease GTH21_RS03015 ENOG4105C4C beta-galactosidase GTH21_RS03020 ENOG4105CI1 PTS System GTH21_RS03025 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GTH21_RS03030 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS03040 ENOG4105YK5 50S ribosomal protein L36 GTH21_RS03055 ENOG4105GSJ Inner membrane protein ylaC GTH21_RS03065 ENOG4108UW5 maltose o-acetyltransferase GTH21_RS03075 ENOG4108UKR Biofilm formation regulator YbaJ GTH21_RS03080 ENOG4105BZS acriflavin resistance protein GTH21_RS03085 ENOG4105C1P efflux transporter, rnd family, mfp subunit GTH21_RS03090 ENOG4107XI7 Tetr family transcriptional regulator GTH21_RS03095 ENOG4105EGS Mechanosensitive ion channel GTH21_RS03100 ENOG4105DNE Transposase GTH21_RS03105 ENOG4106428 Protein of unknown function (DUF2496) GTH21_RS03110 ENOG4108URS primosomal replication protein n'' GTH21_RS03115 ENOG4105WD1 Membrane GTH21_RS03120 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GTH21_RS03125 ENOG4107QMP dna polymerase iii subunits gamma and tau GTH21_RS03130 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GTH21_RS03135 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GTH21_RS03140 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GTH21_RS03145 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GTH21_RS03155 ENOG4107RE1 Inosine-guanosine kinase GTH21_RS03160 ENOG4105CKD glutathione-regulated potassium-efflux system protein GTH21_RS03175 ENOG4105EU0 Major facilitator Superfamily GTH21_RS03180 ENOG4105CGH 5'-nucleotidase GTH21_RS03185 ENOG4108Z66 YbaK ebsC protein GTH21_RS03190 ENOG4105MBR gumn family GTH21_RS03195 ENOG4105C59 p-type ATPase GTH21_RS03200 ENOG4108Z6Z Transcriptional regulator GTH21_RS03205 ENOG4105G5H Membrane GTH21_RS03210 ENOG4107QX8 SPFH domain, Band 7 family protein GTH21_RS03215 ENOG41083J0 (ABC) transporter GTH21_RS03220 ENOG4105C4B ABC transporter, permease GTH21_RS03225 ENOG4107QR8 Thioredoxin GTH21_RS03230 ENOG4105E1F short-chain dehydrogenase reductase GTH21_RS03235 ENOG4108UJV acyl-CoA thioesterase i GTH21_RS03240 ENOG4108I0Y (ABC) transporter GTH21_RS03245 ENOG4105CV6 ABC transporter, permease GTH21_RS03265 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GTH21_RS03270 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GTH21_RS03280 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GTH21_RS03285 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GTH21_RS03290 ENOG4105C8N cysteinyl-tRNA synthetase GTH21_RS03295 ENOG4105WQ3 Rna-binding protein GTH21_RS03300 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GTH21_RS03330 ENOG4105BZN citrate synthase GTH21_RS03345 ENOG4105X0I Fimbrial GTH21_RS03350 ENOG4105GQR Chaperone GTH21_RS03355 ENOG4105CW0 outer membrane usher protein GTH21_RS03370 ENOG4105D1S lipid A biosynthesis GTH21_RS03380 ENOG4108M3R transcriptional activator CadC GTH21_RS03385 ENOG4105D5Q Arginine ornithine antiporter GTH21_RS03390 ENOG4105CXN decarboxylase GTH21_RS03395 ENOG4105DUX Transporter GTH21_RS03400 ENOG4105CRK lysyL-tRNA synthetase GTH21_RS03440 ENOG4105C2J ABC transporter GTH21_RS03445 ENOG4108HWV )-transporter GTH21_RS03460 ENOG4105WBN Transcriptional regulator (LacI family GTH21_RS03465 ENOG4108HKT sucrose-6-phosphate hydrolase GTH21_RS03470 ENOG4105C5Y PTS System GTH21_RS03475 ENOG4108M0B Sucrose porin GTH21_RS03480 ENOG4105D7K pfkb domain protein GTH21_RS03495 ENOG4105KK7 inner membrane protein YiaW GTH21_RS03500 ENOG4105EFX secretion protein, HlyD family GTH21_RS03505 ENOG4105E0A ABC, transporter GTH21_RS03510 ENOG4105EHG Permease protein GTH21_RS03545 ENOG4105CH2 amidohydrolase GTH21_RS03550 ENOG4105E89 ABC transporter GTH21_RS03555 ENOG4105CPC Aldo Keto reductase GTH21_RS03570 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GTH21_RS03580 ENOG4108UAJ Transcriptional regulator GTH21_RS03590 ENOG4105DGU Histone deacetylase GTH21_RS03600 ENOG4105CUB amino acid GTH21_RS03610 ENOG4105CJP fad dependent oxidoreductase GTH21_RS03615 ENOG4105C26 Dehydrogenase GTH21_RS03620 ENOG4108NS2 receptor GTH21_RS03630 ENOG4105C85 amino acid GTH21_RS03635 ENOG4105EAA nucleoside GTH21_RS03645 ENOG4105CK5 oxidoreductase GTH21_RS03660 ENOG4105ISV protein with bipartite regulator domain GTH21_RS03670 ENOG4106PYX Receptor GTH21_RS03675 ENOG4108N3D putative enzyme GTH21_RS03685 ENOG4108GWT fimbrillin MatB GTH21_RS03710 ENOG4105CUY Mechanosensitive ion channel GTH21_RS03730 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GTH21_RS03735 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GTH21_RS03740 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GTH21_RS03745 ENOG4105F3R pts system mannose fructose sorbose family iid GTH21_RS03755 ENOG4108IQ3 PTS system GTH21_RS03765 ENOG4108RCM Nitroreductase GTH21_RS03770 ENOG4105MSB protein, conserved in bacteria GTH21_RS03775 ENOG410630P Transcriptional regulator GTH21_RS03785 ENOG4105HFT AraC family transcriptional regulator GTH21_RS03790 ENOG4105WQ6 Membrane GTH21_RS03820 ENOG4108T58 Mg2 transport protein CorA GTH21_RS03825 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) GTH21_RS03830 ENOG4105T38 integral membrane protein GTH21_RS03835 ENOG4105CHM Aminotransferase GTH21_RS03845 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GTH21_RS03850 ENOG4105DRP amino acid AbC transporter GTH21_RS03855 ENOG4105GBT ABC transporter GTH21_RS03865 ENOG4105EMU Dehydrogenase GTH21_RS03870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GTH21_RS03875 ENOG4108JQ7 (ABC) transporter GTH21_RS03880 ENOG4105C3U ABC transporter GTH21_RS03885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GTH21_RS03890 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GTH21_RS03895 ENOG4105DEF Extracellular solute-binding protein, family 5 GTH21_RS03905 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GTH21_RS03920 ENOG4105C94 Transporter GTH21_RS03925 ENOG4108WN0 inhibitor of vertebrate lysozyme GTH21_RS03930 ENOG4105CUY Mechanosensitive ion channel GTH21_RS03935 ENOG410810E transcriptional regulator, lysR family GTH21_RS03950 ENOG4108R85 Short chain dehydrogenase GTH21_RS03960 ENOG4105CNN ABC, transporter GTH21_RS03965 ENOG4105C2J ABC transporter GTH21_RS03975 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GTH21_RS03980 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GTH21_RS03985 ENOG4105DKT Transcriptional regulator GTH21_RS03990 ENOG4108HHA Transketolase GTH21_RS03995 ENOG4108IUS Transketolase GTH21_RS04000 ENOG4108TSE Transferase GTH21_RS04005 ENOG4107RNH Outer membrane receptor FepA GTH21_RS04010 ENOG4105E93 esterase GTH21_RS04015 ENOG41085A6 mbth domain-containing protein GTH21_RS04020 ENOG4105C0W non-ribosomal peptide synthetase GTH21_RS04025 ENOG4105E0A ABC, transporter GTH21_RS04030 ENOG4105TVJ transport system, permease GTH21_RS04035 ENOG4105DQ5 transport system permease protein GTH21_RS04040 ENOG4105E8G Major facilitator Superfamily GTH21_RS04045 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GTH21_RS04050 ENOG4105E4F Isochorismate synthase GTH21_RS04055 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GTH21_RS04060 ENOG4105WQI isochorismatase GTH21_RS04065 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GTH21_RS04070 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) GTH21_RS04075 ENOG4105D22 carbon starvation protein GTH21_RS04080 ENOG4105VCD cytoplasmic protein GTH21_RS04095 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GTH21_RS04100 ENOG4107SCQ Iron-containing alcohol dehydrogenase GTH21_RS04105 ENOG4105C2J ABC transporter GTH21_RS04110 ENOG4105CNN ABC, transporter GTH21_RS04125 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GTH21_RS04130 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GTH21_RS04135 ENOG4105D6F Phosphatase GTH21_RS04140 ENOG4105CXY transporter GTH21_RS04145 ENOG4105ECY inositol monophosphatase GTH21_RS04155 ENOG4105DZC cytosine deaminase GTH21_RS04165 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GTH21_RS04170 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GTH21_RS04180 ENOG4108M3J Dehydrogenase GTH21_RS04190 ENOG4105CNN ABC, transporter GTH21_RS04200 ENOG4105C2J ABC transporter GTH21_RS04215 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GTH21_RS04220 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) GTH21_RS04225 ENOG4105CHM Aminotransferase GTH21_RS04230 ENOG4105GTN ParB Domain Protein Nuclease GTH21_RS04235 ENOG4105BZV Phosphoadenosine phosphosulfate reductase GTH21_RS04240 ENOG4105DQS Transcriptional regulator GTH21_RS04245 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GTH21_RS04250 ENOG4105D3R alkyl hydroperoxide reductase GTH21_RS04255 ENOG4108JU3 Alkyl hydroperoxide reductase GTH21_RS04260 ENOG4108U51 Universal stress protein GTH21_RS04265 ENOG4105NXH GreA GreB family elongation factor GTH21_RS04270 ENOG4105KTS ribonuclease GTH21_RS04275 ENOG4105CEE C4-dicarboxylate transporter GTH21_RS04280 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) GTH21_RS04300 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) GTH21_RS04305 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GTH21_RS04310 ENOG41064T2 transcriptional regulator, lysR family GTH21_RS04315 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GTH21_RS04320 ENOG4108Z43 UPF0250 protein GTH21_RS04325 ENOG4105DZ1 carboxypeptidase GTH21_RS04330 ENOG4105K6T rare lipoprotein A GTH21_RS04335 ENOG4105CNI cell division protein FtsW GTH21_RS04340 ENOG4105CJN penicillin-binding protein GTH21_RS04345 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GTH21_RS04350 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GTH21_RS04355 ENOG4108TGR phosphatase GTH21_RS04360 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GTH21_RS04365 ENOG4105DJF DNA polymerase III, delta' subunit GTH21_RS04375 ENOG4105C8T Leucyl-tRNA synthetase GTH21_RS04380 ENOG4107PAI alpha helical protein GTH21_RS04395 ENOG4105CDA abc transporter atp-binding protein GTH21_RS04400 ENOG4105DRP amino acid AbC transporter GTH21_RS04405 ENOG4105EAD ABC transporter GTH21_RS04410 ENOG4107RP9 extracellular solute-binding protein, family 3 GTH21_RS04415 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GTH21_RS04420 ENOG4108JU5 Magnesium and cobalt efflux protein GTH21_RS04425 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GTH21_RS04430 ENOG4105C9A Phoh family GTH21_RS04435 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GTH21_RS04440 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GTH21_RS04480 ENOG4105CAQ asparagine synthetase GTH21_RS04485 ENOG4105D4U had-superfamily hydrolase, subfamily iia GTH21_RS04490 ENOG4105E2R ROK family GTH21_RS04495 ENOG4105CE4 GlcNAc 6-P deacetylase GTH21_RS04500 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GTH21_RS04505 ENOG4105CI1 PTS System GTH21_RS04510 ENOG4105CX6 glutaminyL-tRNA synthetase GTH21_RS04520 ENOG4105J5J Outer membrane porin GTH21_RS04525 ENOG4105GX6 (LipO)protein GTH21_RS04535 ENOG41090R7 Ferric uptake GTH21_RS04540 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GTH21_RS04545 ENOG4105NNH LexA regulated protein GTH21_RS04550 ENOG4105EV9 Alpha Beta Hydrolase GTH21_RS04555 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GTH21_RS04560 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GTH21_RS04575 ENOG4105C08 Histidine kinase GTH21_RS04580 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GTH21_RS04585 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GTH21_RS04590 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GTH21_RS04600 ENOG4105XIQ Protein of unknown function (DUF2517) GTH21_RS04605 ENOG4105CVP deoxyribo-dipyrimidine photolyase GTH21_RS04610 ENOG4105DUX Transporter GTH21_RS04615 ENOG4107QNR UPF0135 protein GTH21_RS04620 ENOG4105P4J Allophanate hydrolase, subunit 1 GTH21_RS04625 ENOG4107R7A Allophanate hydrolase subunit 2 GTH21_RS04630 ENOG4105E7W lamb ycsf family protein GTH21_RS04650 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GTH21_RS04655 ENOG4105BZN citrate synthase GTH21_RS04660 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GTH21_RS04665 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GTH21_RS04670 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GTH21_RS04675 ENOG4105E33 succinate dehydrogenase GTH21_RS04680 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GTH21_RS04685 ENOG4105C7S Dehydrogenase GTH21_RS04690 ENOG4105CMV Succinyl-CoA synthetase subunit beta GTH21_RS04695 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GTH21_RS04705 ENOG4105C4M (Ubiquinol oxidase) subunit I GTH21_RS04710 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GTH21_RS04720 ENOG4105KJB cyd operon protein YbgE GTH21_RS04725 ENOG4107YD3 Thioesterase GTH21_RS04730 ENOG4105E02 MotA TolQ exbB proton channel GTH21_RS04740 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GTH21_RS04750 ENOG4105KCK Peptidoglycan-associated lipoprotein GTH21_RS04755 ENOG4105UFD tol-pal system protein YbgF GTH21_RS04800 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GTH21_RS04805 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GTH21_RS04810 ENOG4105PGM cation diffusion facilitator family transporter GTH21_RS04815 ENOG4105JND homeobox protein GTH21_RS04820 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GTH21_RS04825 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GTH21_RS04830 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GTH21_RS04835 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GTH21_RS04840 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GTH21_RS04845 ENOG4105CMR udp-glucose 4-epimerase GTH21_RS04855 ENOG4105DKW ABC transporter GTH21_RS04865 ENOG4105F4R Transcriptional regulator mode GTH21_RS04875 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GTH21_RS04880 ENOG4105E0C molybdate abc transporter GTH21_RS04885 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS04890 ENOG4108K4B hydrolase GTH21_RS04895 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GTH21_RS04910 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component GTH21_RS04915 ENOG4105BZU Histidine kinase GTH21_RS04920 ENOG4108XDN Transcriptional regulator GTH21_RS04955 ENOG4105NBR Pectinesterase GTH21_RS04960 ENOG4105CI2 imidazolone-5-propionate hydrolase GTH21_RS04965 ENOG41088SP formiminoglutamate hydrolase GTH21_RS04980 ENOG4105CGP Urocanate hydratase GTH21_RS04985 ENOG4105C84 Histidine ammonia-lyase GTH21_RS04990 ENOG4105C85 amino acid GTH21_RS04995 ENOG4108V1U phospholipid-binding protein GTH21_RS05000 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GTH21_RS05005 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GTH21_RS05010 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GTH21_RS05015 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GTH21_RS05025 ENOG4108IV0 ABC, transporter GTH21_RS05035 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GTH21_RS05040 ENOG4105ECM Sensor protein basS pmrB GTH21_RS05045 ENOG4105XJC Two component transcriptional regulator (Winged helix family GTH21_RS05050 ENOG4105DIJ Phosphoethanolamine transferase GTH21_RS05055 ENOG4105CHW UPF0052 protein GTH21_RS05060 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GTH21_RS05065 ENOG4108RIR Molybdenum cofactor biosynthesis protein GTH21_RS05070 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GTH21_RS05075 ENOG4105M00 molybdopterin converting factor, subunit 1 GTH21_RS05080 ENOG4108ZAF Molybdopterin GTH21_RS05085 ENOG4105HFZ Membrane GTH21_RS05090 ENOG4107UXM Membrane GTH21_RS05095 ENOG4105DZQ phospholipase D Transphosphatidylase GTH21_RS05100 ENOG4105X23 Endonuclease Exonuclease phosphatase GTH21_RS05105 ENOG4105I9U inner membrane protein ybhQ GTH21_RS05110 ENOG4107QWP ABC-2 type transporter GTH21_RS05115 ENOG4107QWP ABC-2 type transporter GTH21_RS05120 ENOG4105CJ1 ABC, transporter GTH21_RS05125 ENOG4105D0S secretion protein (HlyD GTH21_RS05130 ENOG4107MVR Transcriptional regulator GTH21_RS05135 ENOG4108PZW LysR family Transcriptional regulator GTH21_RS05145 ENOG4105DJB Major Facilitator Superfamily GTH21_RS05165 ENOG4105C1J atp-dependent rna helicase GTH21_RS05170 ENOG4105DVT helicase GTH21_RS05175 ENOG4108MTB glycosyl transferase family GTH21_RS05180 ENOG4105VR4 UPF0379 protein ybiJ GTH21_RS05185 ENOG4105KSC Transcriptional regulator, TraR DksA family GTH21_RS05195 ENOG4105EW6 flavin reductase domain protein, FMN-binding GTH21_RS05200 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GTH21_RS05205 ENOG4105D8X mechanosensitive ion channel GTH21_RS05210 ENOG4105CDA abc transporter atp-binding protein GTH21_RS05215 ENOG4105E5Q amino acid AbC transporter GTH21_RS05220 ENOG4107R0W ABC transporter GTH21_RS05225 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GTH21_RS05240 ENOG4108T1M outer membrane protein x GTH21_RS05245 ENOG4108I6E Sulfatase GTH21_RS05255 ENOG4105KST dependent repressor GTH21_RS05260 ENOG4105F4P )-transporter GTH21_RS05265 ENOG4105CS2 ec 3.2.1.21 GTH21_RS05270 ENOG4108TZY GntR Family Transcriptional Regulator GTH21_RS05275 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GTH21_RS05280 ENOG4105M2Z protein tyrosine serine phosphatase GTH21_RS05285 ENOG4105C5H ABC transporter GTH21_RS05295 ENOG4105DPW Major facilitator superfamily MFS_1 GTH21_RS05300 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS05305 ENOG41072TH Protein of unknown function (DUF1479) GTH21_RS05310 ENOG4108HCJ Hydrolase GTH21_RS05320 ENOG4105F1A Pyruvate formate-lyase GTH21_RS05325 ENOG4105D06 uba thif-type nad fad binding protein GTH21_RS05330 ENOG4105CVM Molybdenum cofactor synthesis domain protein GTH21_RS05335 ENOG4105D44 asparaginase GTH21_RS05340 ENOG4108JQ6 ABC transporter GTH21_RS05345 ENOG4105DEF Extracellular solute-binding protein, family 5 GTH21_RS05350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GTH21_RS05355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GTH21_RS05360 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GTH21_RS05365 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GTH21_RS05370 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway GTH21_RS05375 ENOG4105D8V Glucose sorbosone dehydrogenase GTH21_RS05380 ENOG4108TGY Glutathione S-transferase GTH21_RS05390 ENOG4105DZ1 carboxypeptidase GTH21_RS05395 ENOG4107FB0 transcriptional regulator DeoR family GTH21_RS05400 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GTH21_RS05405 ENOG4107QF7 multi-drug GTH21_RS05410 ENOG4108HCJ Hydrolase GTH21_RS05415 ENOG4106UW1 Major Facilitator superfamily GTH21_RS05420 ENOG4108RFG Tetr family transcriptional regulator GTH21_RS05425 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GTH21_RS05455 ENOG4105ED4 portal protein GTH21_RS05615 ENOG4105ZTC transcriptional activator, Ogr delta GTH21_RS05625 ENOG4105D0C transport protein GTH21_RS05630 ENOG4105GWF inner membrane protein YbjM GTH21_RS05635 ENOG41090BQ Glutaredoxin GTH21_RS05640 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress GTH21_RS05655 ENOG4108RMJ sensory transduction regulator GTH21_RS05660 ENOG4107RUE extracellular solute-binding protein family 1 GTH21_RS05665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS05670 ENOG4105F38 ABC transporter, permease GTH21_RS05675 ENOG4105D38 putrescine abc transporter GTH21_RS05680 ENOG4105RBQ inner membrane protein ybjO GTH21_RS05685 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GTH21_RS05690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GTH21_RS05695 ENOG4105BZU Histidine kinase GTH21_RS05700 ENOG4106TNF Periplasmic binding protein GTH21_RS05705 ENOG4105DMR ABC, transporter GTH21_RS05710 ENOG4105GBT ABC transporter GTH21_RS05715 ENOG4106PMH Extracellular solute-binding protein family 3 GTH21_RS05720 ENOG4105E5Z arginine transporter ATP-binding subunit GTH21_RS05725 ENOG41064MM (LipO)protein GTH21_RS05735 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GTH21_RS05740 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GTH21_RS05745 ENOG4105CGD Nad-dependent epimerase dehydratase GTH21_RS05750 ENOG4105C5W Aldolase GTH21_RS05755 ENOG4105C7K acetolactate synthase GTH21_RS05765 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GTH21_RS05775 ENOG4105DWU Membrane GTH21_RS05780 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GTH21_RS05785 ENOG4105CPB ATP-dependent endonuclease of the OLD family GTH21_RS05790 ENOG4105DJY efflux transporter, rnd family, mfp subunit GTH21_RS05800 ENOG4105VEQ Cold shock protein GTH21_RS05805 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GTH21_RS05810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GTH21_RS05815 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GTH21_RS05820 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GTH21_RS05825 ENOG4108JJ8 (ABC) transporter GTH21_RS05830 ENOG4108JJ9 ABC, transporter GTH21_RS05835 ENOG4105C3M thioredoxin reductase GTH21_RS05845 ENOG4105EW9 transcriptional regulator AsnC family GTH21_RS05850 ENOG4105CNU cell division protein FtsK GTH21_RS05855 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GTH21_RS05860 ENOG4105D1H recombination factor protein RarA GTH21_RS05865 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GTH21_RS05870 ENOG4107QY8 reductase GTH21_RS05875 ENOG4105QAX Iron-sulfur GTH21_RS05880 ENOG4107KGK dmso reductase anchor subunit GTH21_RS05890 ENOG4108ISG Major Facilitator GTH21_RS05895 ENOG4105F1A Pyruvate formate-lyase GTH21_RS05900 ENOG4105C6N Formate acetyltransferase GTH21_RS05905 ENOG4105TMB Formate nitrite transporter GTH21_RS05910 ENOG4105DDY UPF0142 protein ycaO GTH21_RS05915 ENOG4107VMU Membrane GTH21_RS05920 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GTH21_RS05925 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GTH21_RS05930 ENOG4105CAT Cytidine monophosphate kinase GTH21_RS05935 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GTH21_RS05940 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GTH21_RS05945 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GTH21_RS05950 ENOG4105BZ1 (ABC) transporter GTH21_RS05955 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GTH21_RS05960 ENOG4105T0Z Conserved Protein GTH21_RS05965 ENOG4105W49 UPF0434 protein GTH21_RS05970 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GTH21_RS05975 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups GTH21_RS05980 ENOG4107S90 membrAne GTH21_RS05985 ENOG4106371 Methyltransferase GTH21_RS05990 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GTH21_RS05995 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GTH21_RS06000 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GTH21_RS06005 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GTH21_RS06010 ENOG4105EAQ (twin-arginine translocation) pathway signal GTH21_RS06015 ENOG4105C5X domain protein GTH21_RS06020 ENOG4105CGF Aromatic amino acid aminotransferase GTH21_RS06030 ENOG4105C5S asparaginyl-tRNA synthetase GTH21_RS06040 ENOG4107RCH Diaminopropionate ammonia-lyase GTH21_RS06045 ENOG4105C44 Serine transporter GTH21_RS06050 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GTH21_RS06055 ENOG4105CH2 amidohydrolase GTH21_RS06060 ENOG4107RH7 Nicotinate phosphoribosyltransferase GTH21_RS06065 ENOG4105CD8 aminopeptidase N GTH21_RS06075 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GTH21_RS06080 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GTH21_RS06085 ENOG4105GVF (ABC) transporter GTH21_RS06090 ENOG4108UZX fmn reductase GTH21_RS06100 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GTH21_RS06105 ENOG4105QVC MOSC domain-containing protein GTH21_RS06110 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GTH21_RS06115 ENOG4105C5H ABC transporter GTH21_RS06120 ENOG4105F1S paraquat-inducible protein a GTH21_RS06125 ENOG4105DY2 Paraquat-inducible protein b GTH21_RS06130 ENOG4108Q2G (LipO)protein GTH21_RS06135 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) GTH21_RS06140 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GTH21_RS06145 ENOG4105DAN ATP-dependent protease GTH21_RS06150 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GTH21_RS06155 ENOG4105UYK outer membrane protein a GTH21_RS06160 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) GTH21_RS06165 ENOG4108RZ1 DNA transformation protein GTH21_RS06170 ENOG4105EM2 membrane GTH21_RS06175 ENOG410901E Membrane GTH21_RS06180 ENOG41088T4 Helicase IV GTH21_RS06190 ENOG4105K4P CoA-binding domain protein GTH21_RS06195 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) GTH21_RS06200 ENOG4105DR4 Methyltransferase GTH21_RS06205 ENOG4108V1U phospholipid-binding protein GTH21_RS06210 ENOG4108UQN AraC family transcriptional regulator GTH21_RS06215 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GTH21_RS06225 ENOG4108MN8 Membrane GTH21_RS06230 ENOG4107QSI ABC, transporter GTH21_RS06240 ENOG4105BZU Histidine kinase GTH21_RS06245 ENOG4105BZU Histidine kinase GTH21_RS06255 ENOG4105E3J oxidoreductase GTH21_RS06260 ENOG4105C26 Dehydrogenase GTH21_RS06265 ENOG4105DVW rieske (2Fe-2S) GTH21_RS06270 ENOG4105C94 Transporter GTH21_RS06275 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GTH21_RS06280 ENOG4105EJC lysr family transcriptional regulator GTH21_RS06285 ENOG4105CJP fad dependent oxidoreductase GTH21_RS06290 ENOG4105C26 Dehydrogenase GTH21_RS06295 ENOG4107VRI Transcriptional regulator GTH21_RS06300 ENOG4108Z86 Glutamine amidotransferase GTH21_RS06305 ENOG4105CFQ glutamine synthetase GTH21_RS06310 ENOG4105CUB amino acid GTH21_RS06325 ENOG4105CHR reductase GTH21_RS06335 ENOG4105D6F Phosphatase GTH21_RS06340 ENOG4105XH3 GTH21_RS06355 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 GTH21_RS06365 ENOG4105C2W permease GTH21_RS06370 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) GTH21_RS06375 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GTH21_RS06380 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GTH21_RS06385 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) GTH21_RS06390 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GTH21_RS06395 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GTH21_RS06400 ENOG4108R86 Transcriptional regulator GTH21_RS06410 ENOG4105C26 Dehydrogenase GTH21_RS06415 ENOG4105CK7 Sodium proline symporter GTH21_RS06430 ENOG4105D9N nucleoside GTH21_RS06440 ENOG410650H (LipO)protein GTH21_RS06445 ENOG4105DBE peroxidase GTH21_RS06450 ENOG4105D5M phosphate starvation-inducible protein GTH21_RS06455 ENOG4108Z33 Thiol disulfide Interchange Protein GTH21_RS06470 ENOG4105EUB pirin domain protein GTH21_RS06475 ENOG4105HEI LysR family (Transcriptional regulator GTH21_RS06495 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GTH21_RS06505 ENOG4107XHZ cytoplasmic chaperone TorD family protein GTH21_RS06510 ENOG4108UQ5 membrane protein YcdZ GTH21_RS06525 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) GTH21_RS06535 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) GTH21_RS06540 ENOG4105NAC (LipO)protein GTH21_RS06545 ENOG4108W47 Acidic protein msyB GTH21_RS06555 ENOG4105D1S lipid A biosynthesis GTH21_RS06570 ENOG4106974 biofilm formation GTH21_RS06580 ENOG4105PVA Biofilm formation regulatory protein BssS GTH21_RS06585 ENOG4105MEA DNA damage-inducible protein i GTH21_RS06600 ENOG4105EKE dihydroorotase GTH21_RS06605 ENOG4105F3T (LipO)protein GTH21_RS06610 ENOG4105EV4 Multidrug resistance protein mdtH GTH21_RS06615 ENOG4105D9U N-acetyltransferase GTH21_RS06620 ENOG4108YXG UPF0502 protein GTH21_RS06625 ENOG4105EP9 oxidoreductase GTH21_RS06630 ENOG4105CJR Integral membrane protein (MviN GTH21_RS06635 ENOG4105EQ0 Major Facilitator superfamily GTH21_RS06640 ENOG4105CR8 Transcriptional regulator GTH21_RS06645 ENOG4107QQB Ribonuclease E GTH21_RS06655 ENOG4105EI2 Pseudouridine synthase GTH21_RS06660 ENOG4108UHJ MAF-like protein GTH21_RS06665 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GTH21_RS06670 ENOG4105VGS 50s ribosomal protein l32 GTH21_RS06675 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GTH21_RS06680 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GTH21_RS06685 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GTH21_RS06690 ENOG4105CHR reductase GTH21_RS06695 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GTH21_RS06700 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GTH21_RS06705 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GTH21_RS06710 ENOG4105HHA aminodeoxychorismate lyase GTH21_RS06715 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GTH21_RS06720 ENOG4107QRG dna polymerase iii GTH21_RS06725 ENOG4105F8V Hydrolase, tatD family GTH21_RS06730 ENOG4105CI1 PTS System GTH21_RS06735 ENOG4105K59 histidine triad (HIT) protein GTH21_RS06740 ENOG41090DQ Lipoprotein GTH21_RS06745 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) GTH21_RS06760 ENOG4105D0Y UPF0227 protein GTH21_RS06765 ENOG4105CEP NADH dehydrogenase GTH21_RS06770 ENOG4107MBR 17 kDa surface antigen GTH21_RS06785 ENOG4108IND Tetr family transcriptional regulator GTH21_RS06795 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction GTH21_RS06800 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GTH21_RS06805 ENOG4108JA2 transcriptioN-repair coupling factor GTH21_RS06815 ENOG4105D60 lipoprotein releasing system transmembrane protein GTH21_RS06820 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GTH21_RS06825 ENOG4105D60 lipoprotein releasing system transmembrane protein GTH21_RS06830 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GTH21_RS06835 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GTH21_RS06845 ENOG4105CEY Amp-dependent synthetase and ligase GTH21_RS06855 ENOG4108HM4 ABC transporter GTH21_RS06860 ENOG4105D38 putrescine abc transporter GTH21_RS06880 ENOG4105EZE Cupin 4 family protein GTH21_RS06885 ENOG4105IFJ Histidine kinase GTH21_RS06905 ENOG4107QTF adenylosuccinate lyase GTH21_RS06910 ENOG41075W9 High frequency lysogenization protein HflD homolog GTH21_RS06915 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GTH21_RS06930 ENOG4108HMX isocitrate dehydrogenase (NADP) GTH21_RS06935 ENOG4108I1J Integrase GTH21_RS06975 ENOG4108R7K Metal Dependent Phosphohydrolase GTH21_RS06980 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) GTH21_RS06985 ENOG4105H40 GTH21_RS06995 ENOG4105RDA repressor GTH21_RS07000 ENOG41078CG DNA-binding transcriptional regulator GTH21_RS07005 ENOG4108S1U GTH21_RS07015 ENOG4105CAR Terminase, large subunit GTH21_RS07035 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GTH21_RS07050 ENOG4108MXB Protein of unknown function (DUF968) GTH21_RS07055 ENOG4105HGD Antitermination protein GTH21_RS07095 ENOG4105NVB glycoside hydrolase, family 19 GTH21_RS07235 ENOG4105EKQ RNA-directed DNA polymerase GTH21_RS07270 ENOG4108HMX isocitrate dehydrogenase (NADP) GTH21_RS07275 ENOG4108ZHR arsR family transcriptional regulator GTH21_RS07295 ENOG4105XDF Protein of unknown function (DUF1272) GTH21_RS07300 ENOG4105E2A Dehydrogenase GTH21_RS07310 ENOG4108Z9Z response to DNA damage stimulus GTH21_RS07315 ENOG4108N8X transition metal ion binding GTH21_RS07320 ENOG4105WEF catalase GTH21_RS07325 ENOG4105C4M (Ubiquinol oxidase) subunit I GTH21_RS07330 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GTH21_RS07360 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GTH21_RS07370 ENOG4106TD9 Diguanylate cyclase GTH21_RS07375 ENOG4105DHT Metal Dependent Phosphohydrolase GTH21_RS07390 ENOG4105D1S lipid A biosynthesis GTH21_RS07395 ENOG4108NIW Leucine export protein LeuE GTH21_RS07400 ENOG4105S5I Membrane GTH21_RS07415 ENOG4106G4W GTH21_RS07420 ENOG410620I Diguanylate cyclase GTH21_RS07425 ENOG4105UCG Domain of unknown function (DUF333) GTH21_RS07430 ENOG4105K78 MarR family Transcriptional regulator GTH21_RS07435 ENOG4105EWC Purine nucleoside phosphorylase GTH21_RS07440 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GTH21_RS07445 ENOG4105DJ2 Major Facilitator Superfamily GTH21_RS07450 ENOG4105R1U AraC Family Transcriptional Regulator GTH21_RS07455 ENOG4108VMM UPF0756 membrane protein GTH21_RS07460 ENOG4108KXH Ybak prolyl-tRNA synthetase associated GTH21_RS07465 ENOG4108XNZ glycosyl transferase GTH21_RS07470 ENOG4105Y50 Virulence Protein GTH21_RS07480 ENOG4105KT5 UmuD protein GTH21_RS07485 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GTH21_RS07490 ENOG4105CBN LysR family transcriptional regulator GTH21_RS07495 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GTH21_RS07520 ENOG4108V06 Glutathione peroxidase GTH21_RS07530 ENOG4106AKX UPF0229 protein GTH21_RS07535 ENOG4105CYN Serine protein kinase GTH21_RS07540 ENOG4105GNX MltA-interacting MipA family protein GTH21_RS07545 ENOG4105CV8 reductase GTH21_RS07550 ENOG4105DSB aldose 1-epimerase GTH21_RS07555 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GTH21_RS07560 ENOG4105E0X reductase GTH21_RS07565 ENOG4105VUT cytoplasmic protein GTH21_RS07570 ENOG4105N1F Hnh endonuclease GTH21_RS07580 ENOG4105CPQ Dehydrogenase GTH21_RS07585 ENOG4107TE1 transport protein GTH21_RS07590 ENOG4105CPQ Dehydrogenase GTH21_RS07595 ENOG4105D2N Aldolase GTH21_RS07600 ENOG4107UH8 sugar kinase GTH21_RS07605 ENOG4105CPC Aldo Keto reductase GTH21_RS07610 ENOG4105E98 transcriptional regulator DeoR family GTH21_RS07615 ENOG4108KUU Inner membrane metabolite transport protein ydjE GTH21_RS07620 ENOG4108RWI nicotinamidase GTH21_RS07625 ENOG4105HDK L-asparaginase GTH21_RS07630 ENOG4105D07 Signal peptide peptidase, SppA GTH21_RS07635 ENOG41069NU Nitroreductase GTH21_RS07645 ENOG4105SBG acid phosphatase GTH21_RS07650 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GTH21_RS07660 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GTH21_RS07670 ENOG4105D82 Glutamate dehydrogenase GTH21_RS07675 ENOG4105M6F mutator MutT protein GTH21_RS07680 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GTH21_RS07685 ENOG4107RM6 sulfurtransferase GTH21_RS07690 ENOG4108VGW abc transporter atp-binding protein GTH21_RS07695 ENOG4105CXZ ABC transporter, permease GTH21_RS07700 ENOG4105VNH ABC transporter solute-binding protein GTH21_RS07705 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GTH21_RS07710 ENOG4108N5C SNARE associated Golgi protein-related protein GTH21_RS07715 ENOG4108RSN SNARE associated Golgi GTH21_RS07720 ENOG4105CGK Exodeoxyribonuclease III GTH21_RS07730 ENOG4105F4X arginine GTH21_RS07735 ENOG4105C26 Dehydrogenase GTH21_RS07740 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) GTH21_RS07750 ENOG4108SPG Periplasmic Protein GTH21_RS07755 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) GTH21_RS07765 ENOG4105KKI DNA-binding transcriptional activator OsmE GTH21_RS07770 ENOG4105VZJ PTS System GTH21_RS07795 ENOG4105VCP PTS System GTH21_RS07800 ENOG4105EZV Transcriptional regulator GTH21_RS07805 ENOG4105F8D glycoside hydrolase family 4 GTH21_RS07810 ENOG410901P UPF0249 protein GTH21_RS07815 ENOG4105CH6 catalase GTH21_RS07820 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) GTH21_RS07825 ENOG4108ETY sodium dicarboxylate symporter GTH21_RS07830 ENOG4107K5X Membrane-bound metal-dependent hydrolase GTH21_RS07835 ENOG4105CHR reductase GTH21_RS07840 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GTH21_RS07845 ENOG4107PN8 YfeABCD locus regulator GTH21_RS07850 ENOG4105NAU thioesterase Superfamily protein GTH21_RS07855 ENOG4107RNH Outer membrane receptor FepA GTH21_RS07860 ENOG4107835 probably involved in intracellular septation (By similarity) GTH21_RS07865 ENOG4108S3I UPF0259 membrane protein GTH21_RS07870 ENOG4105PI0 Ferredoxin GTH21_RS07875 ENOG4105EIF outer membrane protein W GTH21_RS07880 ENOG4107E2E PKHD-type hydroxylase GTH21_RS07885 ENOG4108IU3 tonb-dependent siderophore receptor GTH21_RS07930 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GTH21_RS07935 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GTH21_RS07940 ENOG4105DK0 Indole-3-glycerol phosphate synthase GTH21_RS07945 ENOG4108EFP Anthranilate synthase component II GTH21_RS07950 ENOG4105CRQ synthase (Component I) GTH21_RS07955 ENOG4105DB7 PHP domain protein GTH21_RS07960 ENOG4107RTD sua5 ycio yrdc ywlc family protein GTH21_RS07970 ENOG4105ETT transcriptional Regulator, LysR family GTH21_RS07980 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GTH21_RS07985 ENOG4105UBK short-chain dehydrogenase reductase GTH21_RS07995 ENOG4105ERU peptidase GTH21_RS08000 ENOG4105RKX Protein of unknown function (DUF2498) GTH21_RS08005 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GTH21_RS08010 ENOG4107R11 Transcriptional regulator GTH21_RS08020 ENOG4107QM5 aconitate hydratase GTH21_RS08025 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GTH21_RS08030 ENOG4105EYK Phosphatidylglycerophosphatase B GTH21_RS08035 ENOG4105Q4A inner membrane protein yciS GTH21_RS08040 ENOG4105CFV Tetratricopeptide repeat protein GTH21_RS08050 ENOG4108ZJT translation initiation factor, Sui1 GTH21_RS08055 ENOG41061RM osmotically inducible lipoprotein GTH21_RS08065 ENOG4105N2W Transcriptional regulator GTH21_RS08075 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GTH21_RS08080 ENOG4105Q4T oxidoreductase GTH21_RS08085 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GTH21_RS08095 ENOG4105ETS cytosine purines uracil thiamine allantoin GTH21_RS08100 ENOG4108JQ2 peptide transport system atp-binding protein GTH21_RS08105 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GTH21_RS08110 ENOG4108EU3 peptide transport system, permease GTH21_RS08180 ENOG4105KT5 UmuD protein GTH21_RS08185 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GTH21_RS08195 ENOG4108RAV Conserved protein GTH21_RS08200 ENOG4108EKA peptide transport system, permease GTH21_RS08205 ENOG4108J59 Extracellular solute-binding protein, family 5 GTH21_RS08220 ENOG41063ZK Transcriptional Regulator AraC Family GTH21_RS08225 ENOG4105CH2 amidohydrolase GTH21_RS08235 ENOG4105E51 psp operon transcriptional activator GTH21_RS08240 ENOG41087YS Phage shock protein A GTH21_RS08245 ENOG4105YYT phage shock protein B GTH21_RS08250 ENOG4105FM1 phage shock protein C GTH21_RS08255 ENOG4105NNG Peripheral inner membrane phage-shock protein GTH21_RS08260 ENOG4105CM6 amino acid regulated cytosolic protein GTH21_RS08265 ENOG4106K28 UPF0283 membrane protein GTH21_RS08270 ENOG4105W8I Transcriptional regulator GTH21_RS08275 ENOG4105F8D glycoside hydrolase family 4 GTH21_RS08280 ENOG4108JU8 Transcriptional regulator GTH21_RS08285 ENOG4108KK1 membrane protein AbrB duplication GTH21_RS08290 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GTH21_RS08295 ENOG4107S8C mandelate racemase muconate lactonizing GTH21_RS08300 ENOG4105KXI murein peptide amidase A GTH21_RS08310 ENOG4107QSI ABC, transporter GTH21_RS08325 ENOG4105EQ2 LysR family Transcriptional regulator GTH21_RS08330 ENOG4105ENX hydrolase GTH21_RS08335 ENOG4107RTG Major Facilitator superfamily GTH21_RS08360 ENOG4105CBN LysR family transcriptional regulator GTH21_RS08375 ENOG4108Z0Z intracellular protease Pfpi family GTH21_RS08405 ENOG4108ZG0 Ompa motb domain protein GTH21_RS08415 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GTH21_RS08510 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GTH21_RS08515 ENOG4108XFH Transcriptional regulator GTH21_RS08540 ENOG4105HEI LysR family (Transcriptional regulator GTH21_RS08580 ENOG4105D01 (LipO)protein GTH21_RS08590 ENOG4108UMI ABC transporter, permease GTH21_RS08595 ENOG4105CGF Aromatic amino acid aminotransferase GTH21_RS08605 ENOG4105F7P transcriptional regulator AsnC family GTH21_RS08610 ENOG4105C85 amino acid GTH21_RS08625 ENOG4105D9R oxidoreductase GTH21_RS08630 ENOG4105E98 transcriptional regulator DeoR family GTH21_RS08635 ENOG4107RX3 Mg2 transporter protein cora family protein GTH21_RS08640 ENOG4105C1J atp-dependent rna helicase GTH21_RS08650 ENOG4108RW8 Universal stress protein F GTH21_RS08660 ENOG4105FCK Membrane GTH21_RS08665 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GTH21_RS08670 ENOG4105IKK cytoplasmic protein GTH21_RS08675 ENOG41090X5 Heat shock protein hslJ GTH21_RS08680 ENOG4105C5I Dehydrogenase GTH21_RS08685 ENOG4108KF1 Membrane GTH21_RS08690 ENOG4107H52 Dicarboxylate transport GTH21_RS08695 ENOG410689M (LipO)protein GTH21_RS08700 ENOG4105WXT Conserved Protein GTH21_RS08705 ENOG4108WFR AraC Family Transcriptional Regulator GTH21_RS08710 ENOG4105C26 Dehydrogenase GTH21_RS08725 ENOG4105F11 amine oxidase GTH21_RS08730 ENOG4105DXM phenylacetic acid degradation protein GTH21_RS08735 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GTH21_RS08740 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GTH21_RS08745 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GTH21_RS08750 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GTH21_RS08755 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GTH21_RS08760 ENOG4105E39 Enoyl-CoA hydratase GTH21_RS08765 ENOG4108UKI Enoyl-CoA hydratase GTH21_RS08770 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GTH21_RS08775 ENOG4108ZJI phenylacetic acid degradation protein GTH21_RS08780 ENOG4105CHU acetyl-coa acetyltransferase GTH21_RS08785 ENOG4105DZS Phenylacetate-CoA ligase GTH21_RS08790 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein GTH21_RS08795 ENOG4108Z0R Transferase GTH21_RS08805 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GTH21_RS08810 ENOG4105CQ7 ATP-dependent helicase GTH21_RS08820 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GTH21_RS08840 ENOG410642W LysR family Transcriptional regulator GTH21_RS08845 ENOG4108FN7 Aldo keto reductase GTH21_RS08850 ENOG4105D82 Glutamate dehydrogenase GTH21_RS08860 ENOG4105C8Y Acetylornithine aminotransferase GTH21_RS08865 ENOG4105F4X arginine GTH21_RS08870 ENOG4105C26 Dehydrogenase GTH21_RS08875 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) GTH21_RS08880 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) GTH21_RS08890 ENOG4105CSH Transporter GTH21_RS08895 ENOG4107DB1 DUF218 domain GTH21_RS08905 ENOG4105C26 Dehydrogenase GTH21_RS08910 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GTH21_RS08915 ENOG4105VPI YqaE family transport protein GTH21_RS08920 ENOG41064WM Uncharacterized protein YcgX GTH21_RS08930 ENOG41066VF YeeE YedE family protein GTH21_RS08945 ENOG41061EV selenium-binding protein YdfZ GTH21_RS08955 ENOG4105C87 Aminotransferase class I and II GTH21_RS08960 ENOG4105CI1 PTS System GTH21_RS08965 ENOG4107P2S Transcriptional regulator GTH21_RS08970 ENOG4106J39 exported protein GTH21_RS08975 ENOG4105EIP mannose-6-phosphate isomerase GTH21_RS08980 ENOG4107GFK fumarate GTH21_RS08985 ENOG4105C9Q fumarate hydratase class II GTH21_RS08995 ENOG4105JJR Histidine kinase GTH21_RS09005 ENOG4107EXC regulatoR GTH21_RS09010 ENOG4105RA2 Membrane GTH21_RS09015 ENOG410642E Short chain dehydrogenase GTH21_RS09020 ENOG4105D5Q Arginine ornithine antiporter GTH21_RS09025 ENOG4105C5D exported protein GTH21_RS09040 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GTH21_RS09045 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GTH21_RS09050 ENOG410671Z uncharacterized protein ydiH GTH21_RS09055 ENOG4105Q9Y Universal stress protein GTH21_RS09060 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GTH21_RS09065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GTH21_RS09075 ENOG4105CFC Transporter GTH21_RS09080 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GTH21_RS09090 ENOG4106KR7 LysR family Transcriptional regulator GTH21_RS09095 ENOG4108DG9 Smr protein MutS2 GTH21_RS09100 ENOG4107HP6 Transcriptional regulator GTH21_RS09110 ENOG4107QNJ CoA-transferase subunit B GTH21_RS09115 ENOG4105CHU acetyl-coa acetyltransferase GTH21_RS09120 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GTH21_RS09125 ENOG4105F2Z 3-oxoadipate enol-lactonase GTH21_RS09130 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GTH21_RS09140 ENOG4107GFK fumarate GTH21_RS09160 ENOG4108MRH transcriptional regulatory protein GTH21_RS09165 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GTH21_RS09175 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GTH21_RS09180 ENOG4105DWT malate dehydrogenase (quinone) GTH21_RS09185 ENOG4108K70 Transcriptional regulator GTH21_RS09190 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GTH21_RS09195 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase GTH21_RS09200 ENOG4107TT2 Auxin Efflux Carrier GTH21_RS09230 ENOG4105DSF transport protein GTH21_RS09235 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) GTH21_RS09240 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) GTH21_RS09250 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap GTH21_RS09270 ENOG4105CTD carboxy-peptidase GTH21_RS09275 ENOG4105D94 Major Facilitator Superfamily GTH21_RS09280 ENOG4106NZI LysR family Transcriptional regulator GTH21_RS09285 ENOG4105DAG ROK family GTH21_RS09290 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GTH21_RS09295 ENOG4105CMQ Chloride channel GTH21_RS09300 ENOG4108NEM leader-binding protein dmsD GTH21_RS09305 ENOG4107KGK dmso reductase anchor subunit GTH21_RS09310 ENOG4105QAX Iron-sulfur GTH21_RS09315 ENOG4107QY8 reductase GTH21_RS09320 ENOG4105KBG Protein of unknown function (DUF1161) GTH21_RS09330 ENOG4108MK9 spermidine N(1)-acetyltransferase GTH21_RS09335 ENOG4105M5Q UPF0482 protein GTH21_RS09340 ENOG4105KK4 UPF0060 membrane protein GTH21_RS09345 ENOG4108I5G Major Facilitator superfamily GTH21_RS09350 ENOG4105DEI Mannitol dehydrogenase GTH21_RS09355 ENOG4108U51 Universal stress protein GTH21_RS09360 ENOG4107XBN GntR Family Transcriptional Regulator GTH21_RS09365 ENOG4105EMU Dehydrogenase GTH21_RS09370 ENOG4105DGW oligopeptidase A GTH21_RS09380 ENOG4105R1U AraC Family Transcriptional Regulator GTH21_RS09385 ENOG4108RAV Conserved protein GTH21_RS09400 ENOG4108WQH regulatoR GTH21_RS09415 ENOG4108ZNX Heat shock protein GTH21_RS09420 ENOG4108WTK competence damage-inducible protein GTH21_RS09425 ENOG4105BZU Histidine kinase GTH21_RS09445 ENOG4105C6Z Gluconate GTH21_RS09450 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GTH21_RS09455 ENOG4105FB2 class II Aldolase GTH21_RS09460 ENOG4105G63 Type III effector Hrp-dependent GTH21_RS09470 ENOG4105MVE transcriptional regulator GTH21_RS09475 ENOG4108J4B Beta-lactamase GTH21_RS09485 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GTH21_RS09490 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GTH21_RS09495 ENOG4105CNT hydrolase family 2 GTH21_RS09505 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS09525 ENOG4105ECQ AraC Family Transcriptional Regulator GTH21_RS09540 ENOG41083Z3 extracellular ligand-binding receptor GTH21_RS09545 ENOG4105C32 Amino acid ABC transporter (Permease) GTH21_RS09550 ENOG4105CNN ABC, transporter GTH21_RS09560 ENOG4108IV0 ABC, transporter GTH21_RS09570 ENOG4105E5W Transporter GTH21_RS09575 ENOG4108594 Permease of the drug metabolite transporter GTH21_RS09580 ENOG4106DNR multiple antibiotic resistance protein GTH21_RS09585 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF GTH21_RS09590 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GTH21_RS09600 ENOG41082NP Multiple antibiotic resistance GTH21_RS09605 ENOG4105F27 Major Facilitator GTH21_RS09610 ENOG4105JAB phenazine biosynthesis protein, phzf family GTH21_RS09615 ENOG4105CHR reductase GTH21_RS09620 ENOG4108R66 Conserved Protein GTH21_RS09635 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GTH21_RS09640 ENOG4105C0A alcohol dehydrogenase GTH21_RS09645 ENOG4107S2N Type III effector Hrp-dependent GTH21_RS09650 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GTH21_RS09655 ENOG4105MVE transcriptional regulator GTH21_RS09660 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GTH21_RS09670 ENOG4105EGI Transcriptional regulator GTH21_RS09675 ENOG4105C26 Dehydrogenase GTH21_RS09680 ENOG4105CSV Glutaminase GTH21_RS09685 ENOG4105M0C cytoplasmic protein GTH21_RS09690 ENOG4105BZU Histidine kinase GTH21_RS09700 ENOG4107QZW Altronate oxidoreductase GTH21_RS09750 ENOG4105F9N Major Facilitator Superfamily GTH21_RS09760 ENOG4105CBP Major Facilitator GTH21_RS09765 ENOG4105EGI Transcriptional regulator GTH21_RS09775 ENOG4105EA8 2-Nitropropane dioxygenase GTH21_RS09780 ENOG4108UMI ABC transporter, permease GTH21_RS09790 ENOG4105D01 (LipO)protein GTH21_RS09800 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GTH21_RS09815 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions GTH21_RS09835 ENOG4108KSA LysR family transcriptional regulator GTH21_RS09840 ENOG41061H0 Monooxygenase GTH21_RS09845 ENOG4105C2W permease GTH21_RS09850 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) GTH21_RS09855 ENOG4105VT2 5-hydroxyisourate hydrolase GTH21_RS09860 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein GTH21_RS09865 ENOG4105CAF HipA N-terminal domain protein GTH21_RS09870 ENOG4105F32 YngK protein GTH21_RS09880 ENOG4105CW0 outer membrane usher protein GTH21_RS09885 ENOG4108VCD Chaperone GTH21_RS09900 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GTH21_RS09915 ENOG4105BZU Histidine kinase GTH21_RS09920 ENOG4105NIV Esterase GTH21_RS09940 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GTH21_RS09945 ENOG4105C54 Major Facilitator superfamily GTH21_RS09955 ENOG4105F8D glycoside hydrolase family 4 GTH21_RS09960 ENOG4105CI1 PTS System GTH21_RS09965 ENOG4107YCY Transcriptional regulator GTH21_RS09975 ENOG4105JQN Transcriptional regulator GTH21_RS09985 ENOG4107VHA regulatoR GTH21_RS09990 ENOG4105BZW Glycerate kinase GTH21_RS10010 ENOG4105CHU acetyl-coa acetyltransferase GTH21_RS10015 ENOG4105CHR reductase GTH21_RS10020 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) GTH21_RS10035 ENOG4105EDR glucose galactose transporter GTH21_RS10040 ENOG4108RVA ribokinase GTH21_RS10045 ENOG4105UP7 3-epimerase GTH21_RS10050 ENOG4105E98 transcriptional regulator DeoR family GTH21_RS10055 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GTH21_RS10060 ENOG4105CMG Carbohydrate kinase GTH21_RS10065 ENOG4105MVE transcriptional regulator GTH21_RS10080 ENOG4105ENX hydrolase GTH21_RS10120 ENOG4105CPC Aldo Keto reductase GTH21_RS10130 ENOG4107SET aldo keto reductase GTH21_RS10135 ENOG4105CPC Aldo Keto reductase GTH21_RS10140 ENOG4105EQ2 LysR family Transcriptional regulator GTH21_RS10145 ENOG4105RHY Pfam:UPF0157 GTH21_RS10150 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta GTH21_RS10160 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GTH21_RS10165 ENOG4105CXY transporter GTH21_RS10170 ENOG4105CNW domain protein GTH21_RS10185 ENOG4109066 lysm domain bon superfamily protein GTH21_RS10215 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS10220 ENOG4105C2J ABC transporter GTH21_RS10225 ENOG4105CNN ABC, transporter GTH21_RS10240 ENOG4107PP3 Acetylornithine deacetylase GTH21_RS10255 ENOG4105HEI LysR family (Transcriptional regulator GTH21_RS10260 ENOG4105CBN LysR family transcriptional regulator GTH21_RS10270 ENOG410829K Lysine exporter protein (Lyse ygga) GTH21_RS10275 ENOG4105DM4 PTS System GTH21_RS10280 ENOG4108YRF PTS System GTH21_RS10290 ENOG4105UP7 3-epimerase GTH21_RS10295 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GTH21_RS10305 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GTH21_RS10310 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS10320 ENOG4105FCD Major Facilitator GTH21_RS10350 ENOG4105CSH Transporter GTH21_RS10355 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain GTH21_RS10360 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GTH21_RS10370 ENOG4105CBN LysR family transcriptional regulator GTH21_RS10385 ENOG4105C5R Aminotransferase GTH21_RS10395 ENOG4105E5Q amino acid AbC transporter GTH21_RS10415 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GTH21_RS10440 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GTH21_RS10465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GTH21_RS10495 ENOG41089BK Glutamine amido-transferase GTH21_RS10510 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GTH21_RS10555 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GTH21_RS10560 ENOG4107QUY Guanine deaminase GTH21_RS10565 ENOG4105BZU Histidine kinase GTH21_RS10570 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS10580 ENOG4105CIB oxidoreductase Domain protein GTH21_RS10595 ENOG4105ETU transcriptional activator (TenA GTH21_RS10600 ENOG4108YI8 ABC transporter GTH21_RS10605 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GTH21_RS10610 ENOG4107Z6I Thiamine biosynthesis protein GTH21_RS10615 ENOG4108JPW Aminotransferase GTH21_RS10620 ENOG4105DY8 decarboxylase GTH21_RS10635 ENOG4105E0F Histidine kinase GTH21_RS10645 ENOG4108J2P Alpha beta hydrolase fold GTH21_RS10650 ENOG4108IGT Dipeptidase GTH21_RS10660 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) GTH21_RS10665 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) GTH21_RS10685 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF GTH21_RS10690 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GTH21_RS10710 ENOG4106KR7 LysR family Transcriptional regulator GTH21_RS10715 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GTH21_RS10720 ENOG4105D6Z AFG1 family ATPase GTH21_RS10725 ENOG4105KT7 mgtC SapB transporter GTH21_RS10730 ENOG4108KUU Inner membrane metabolite transport protein ydjE GTH21_RS10735 ENOG4105VCP PTS System GTH21_RS10740 ENOG4105VZJ PTS System GTH21_RS10765 ENOG4105CK1 PTS System GTH21_RS10770 ENOG4105C5Q Transcriptional regulator GTH21_RS10775 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GTH21_RS10780 ENOG4105FFC UPF0187 protein GTH21_RS10805 ENOG4108Z9K Osmotically inducible protein GTH21_RS10815 ENOG4108YDI single-species biofilm formation on inanimate substrate GTH21_RS10835 ENOG4105CG3 alpha amylase, catalytic region GTH21_RS10845 ENOG4108N8X transition metal ion binding GTH21_RS10860 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GTH21_RS10865 ENOG4105N0E Protein of unknown function (DUF2543) GTH21_RS10870 ENOG4105EQ2 LysR family Transcriptional regulator GTH21_RS10890 ENOG4107R1I NAD-dependent malic enzyme GTH21_RS10905 ENOG4105C5H ABC transporter GTH21_RS10920 ENOG4105DQ4 alcohol dehydrogenase GTH21_RS10935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GTH21_RS10940 ENOG4108JQ6 ABC transporter GTH21_RS10955 ENOG4105F27 Major Facilitator GTH21_RS10965 ENOG4105CSR polyphosphate kinase 2 GTH21_RS10980 ENOG4108MG3 formate dehydrogenase GTH21_RS10985 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GTH21_RS11010 ENOG4108UKV benzoate 1,2-dioxygenase GTH21_RS11020 ENOG410626B catechol 1,2-dioxygenase GTH21_RS11025 ENOG4105NN7 muconolactone delta-isomerase GTH21_RS11030 ENOG4105DTQ mandelate racemase muconate lactonizing GTH21_RS11035 ENOG4107HP6 Transcriptional regulator GTH21_RS11050 ENOG4107QND Nitrite extrusion protein GTH21_RS11055 ENOG4105CRU nitrate reductase, alpha subunit GTH21_RS11060 ENOG4108IUE nitrate reductase beta subunit GTH21_RS11065 ENOG4108NZN Respiratory nitrate reductase 2 delta chain GTH21_RS11070 ENOG4105D0D Nitrate reductase 2, gamma subunit GTH21_RS11075 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GTH21_RS11080 ENOG4107RCV ABC transporter, permease GTH21_RS11085 ENOG4105C4Y ABC transporter GTH21_RS11090 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS11095 ENOG4108MEJ flavin reductase domain protein GTH21_RS11130 ENOG4108N27 Glutathione S-transferase GTH21_RS11140 ENOG4105CDA abc transporter atp-binding protein GTH21_RS11145 ENOG4105DRP amino acid AbC transporter GTH21_RS11155 ENOG4105EAB amino acid AbC transporter GTH21_RS11170 ENOG4105DEN Luciferase family GTH21_RS11185 ENOG4105C85 amino acid GTH21_RS11195 ENOG4108NS2 receptor GTH21_RS11200 ENOG4105CHB tonB-dependent Receptor GTH21_RS11205 ENOG4105CI2 imidazolone-5-propionate hydrolase GTH21_RS11210 ENOG41065TG regulatoR GTH21_RS11220 ENOG4105DU0 nucleoside hydrolase GTH21_RS11225 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GTH21_RS11235 ENOG4108Z7F N-acetyltransferase GTH21_RS11240 ENOG4108T9Y Inner membrane protein ydcZ GTH21_RS11245 ENOG4105R71 cytoplasmic protein GTH21_RS11250 ENOG4105DEF Extracellular solute-binding protein, family 5 GTH21_RS11265 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GTH21_RS11270 ENOG410654E Membrane GTH21_RS11295 ENOG4105C26 Dehydrogenase GTH21_RS11300 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GTH21_RS11305 ENOG4105D81 ABC transporter, permease GTH21_RS11310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS11315 ENOG4107TYH extracellular solute-binding protein family 1 GTH21_RS11320 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GTH21_RS11325 ENOG4105C4M (Ubiquinol oxidase) subunit I GTH21_RS11330 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GTH21_RS11350 ENOG4105CFP Peptidase U32 GTH21_RS11360 ENOG4108JCI Transcriptional regulator GTH21_RS11365 ENOG4105DKK Benzoate GTH21_RS11370 ENOG4105UEI Transcriptional Regulator AraC Family GTH21_RS11380 ENOG4108KKZ (LipO)protein GTH21_RS11385 ENOG41088CC tellurite resistance protein tehB GTH21_RS11390 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein GTH21_RS11395 ENOG4107WE3 acetyltransferase YdcK GTH21_RS11400 ENOG4108Z9I -acetyltransferase GTH21_RS11415 ENOG4105EBR Carboxylesterase GTH21_RS11420 ENOG4105E32 cytoplasmic protein GTH21_RS11425 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta GTH21_RS11430 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GTH21_RS11435 ENOG4105DDW LysR family Transcriptional regulator GTH21_RS11455 ENOG4105CPW cytochrome b561 GTH21_RS11475 ENOG4105EQ0 Major Facilitator superfamily GTH21_RS11480 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GTH21_RS11485 ENOG4105D9R oxidoreductase GTH21_RS11495 ENOG4105CS2 ec 3.2.1.21 GTH21_RS11505 ENOG4105M9B inner membrane protein ydgK GTH21_RS11530 ENOG4108UQQ Electron transport complex GTH21_RS11540 ENOG4105CSM endonuclease III GTH21_RS11550 ENOG4108K3A Glutathione S-transferase GTH21_RS11555 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GTH21_RS11560 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GTH21_RS11565 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GTH21_RS11570 ENOG410642K Lysozyme inhibitor GTH21_RS11575 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GTH21_RS11580 ENOG4108XTF Outer Membrane Lipoprotein GTH21_RS11585 ENOG4105BZU Histidine kinase GTH21_RS11600 ENOG4105Y49 secretion protein, HlyD family GTH21_RS11605 ENOG4105DSW Fusaric acid resistance protein GTH21_RS11610 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GTH21_RS11615 ENOG4107RGM aldo keto reductase GTH21_RS11620 ENOG4105XZD Fe-S protein GTH21_RS11625 ENOG4108WUH Transcriptional regulator, TetR family GTH21_RS11630 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GTH21_RS11635 ENOG4108UYE Lactoylglutathione lyase GTH21_RS11640 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GTH21_RS11645 ENOG4105M2J Glutaredoxin GTH21_RS11650 ENOG4105K4H Nlp p60 protein GTH21_RS11660 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GTH21_RS11665 ENOG4105F27 Major Facilitator GTH21_RS11675 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS11680 ENOG4105F52 Transcriptional regulator GTH21_RS11685 ENOG4105CZQ inner membrane transport protein YdhC GTH21_RS11690 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GTH21_RS11695 ENOG4108R6K riboflavin synthase, subunit alpha GTH21_RS11700 ENOG4107QI1 Mate efflux family protein GTH21_RS11710 ENOG4108URH decarboxylase GTH21_RS11755 ENOG4105CY0 Metallo-Beta-Lactamase GTH21_RS11785 ENOG4107B2H carbonic anhydrase GTH21_RS11795 ENOG4105E98 transcriptional regulator DeoR family GTH21_RS11800 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GTH21_RS11825 ENOG4105C3U ABC transporter GTH21_RS11830 ENOG4108JQ7 (ABC) transporter GTH21_RS11890 ENOG4105EMY transcriptional regulator GTH21_RS11900 ENOG4107TTD cytosine deaminase GTH21_RS11905 ENOG4105KME endoribonuclease L-psp GTH21_RS11925 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GTH21_RS11930 ENOG4105CQB FAD linked oxidase domain protein GTH21_RS11955 ENOG4106NZI LysR family Transcriptional regulator GTH21_RS11965 ENOG4107QNJ CoA-transferase subunit B GTH21_RS11975 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GTH21_RS11980 ENOG4105CY2 Citrate transporter GTH21_RS11985 ENOG4105DTD Dehydrogenase GTH21_RS12000 ENOG4105C7K acetolactate synthase GTH21_RS12005 ENOG4105CHR reductase GTH21_RS12020 ENOG4105BZS acriflavin resistance protein GTH21_RS12035 ENOG4105E3W Two component transcriptional regulator (Winged helix family GTH21_RS12040 ENOG41062D9 Histidine kinase GTH21_RS12055 ENOG410822N TonB family GTH21_RS12080 ENOG4105KWW Biogenesis protein GTH21_RS12085 ENOG4107QX9 Thiol disulfide interChange protein GTH21_RS12090 ENOG4105DA4 cytochrome c-type biogenesis protein GTH21_RS12095 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GTH21_RS12105 ENOG41060IM Heme exporter protein GTH21_RS12110 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GTH21_RS12115 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GTH21_RS12145 ENOG4107Z33 ABC transporter, permease GTH21_RS12150 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GTH21_RS12160 ENOG4105DG4 malate L-lactate dehydrogenase GTH21_RS12165 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GTH21_RS12190 ENOG41083G8 Multidrug resistance protein MdtM GTH21_RS12200 ENOG4105KZM cytoplasmic protein GTH21_RS12205 ENOG4105CDA abc transporter atp-binding protein GTH21_RS12210 ENOG4105E5Q amino acid AbC transporter GTH21_RS12215 ENOG4106PMH Extracellular solute-binding protein family 3 GTH21_RS12235 ENOG4105DQ5 transport system permease protein GTH21_RS12240 ENOG4105E0A ABC, transporter GTH21_RS12250 ENOG4108IY8 ABC, transporter GTH21_RS12255 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GTH21_RS12275 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GTH21_RS12280 ENOG4105CR8 Transcriptional regulator GTH21_RS12285 ENOG4108T2C cysteine dioxygenase type I GTH21_RS12300 ENOG4108SC4 )-transporter GTH21_RS12305 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GTH21_RS12315 ENOG4105IKQ hydratase GTH21_RS12320 ENOG4107UB2 Alpha beta hydrolase fold GTH21_RS12330 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GTH21_RS12335 ENOG4108K2P TRANSCRIPTIONal GTH21_RS12340 ENOG4105S10 periplasmic binding protein GTH21_RS12345 ENOG4105EHG Permease protein GTH21_RS12350 ENOG4108W0P ABC transporter GTH21_RS12355 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein GTH21_RS12360 ENOG4105E2X shikimate dehydrogenase GTH21_RS12365 ENOG4105DJB Major Facilitator Superfamily GTH21_RS12380 ENOG4105RFR Protein of unknown function (DUF2767) GTH21_RS12395 ENOG4105CA9 Pyruvate kinase GTH21_RS12405 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GTH21_RS12410 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GTH21_RS12415 ENOG4105C9B Cysteine desulfurase GTH21_RS12420 ENOG4105JRK feS assembly protein SufD GTH21_RS12425 ENOG4105C3K feS assembly ATPase SufC GTH21_RS12430 ENOG4105DIW FeS assembly protein SUFB GTH21_RS12435 ENOG4108Z4V iron-sulfur cluster assembly GTH21_RS12455 ENOG4105KBX Transcriptional regulator, TetR family GTH21_RS12460 ENOG4105DMF Dehydrogenase GTH21_RS12485 ENOG4106KR7 LysR family Transcriptional regulator GTH21_RS12495 ENOG4105EHG Permease protein GTH21_RS12500 ENOG4105E0A ABC, transporter GTH21_RS12510 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GTH21_RS12525 ENOG4105Y3U Transglycosylase-associated protein GTH21_RS12530 ENOG4105KA0 thioesterase Superfamily protein GTH21_RS12535 ENOG4105CQB FAD linked oxidase domain protein GTH21_RS12540 ENOG4105IPI Membrane GTH21_RS12550 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GTH21_RS12565 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GTH21_RS12575 ENOG4105CNG UPF0061 protein GTH21_RS12580 ENOG4108QBX (LipO)protein GTH21_RS12590 ENOG4108V06 Glutathione peroxidase GTH21_RS12595 ENOG4105D01 (LipO)protein GTH21_RS12610 ENOG4105RQF LysR family Transcriptional regulator GTH21_RS12615 ENOG4105MWK D-amino acid dehydrogenase, small subunit GTH21_RS12625 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GTH21_RS12630 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GTH21_RS12635 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GTH21_RS12650 ENOG41082NX 50s ribosomal protein l35 GTH21_RS12655 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GTH21_RS12670 ENOG4108NE3 Salt-induced outer membrane protein GTH21_RS12675 ENOG4105DE4 1-phosphofructokinase GTH21_RS12680 ENOG4105P10 Uncharacterized protein ydiZ GTH21_RS12690 ENOG410822N TonB family GTH21_RS12695 ENOG4105K9H YciI-like protein GTH21_RS12705 ENOG4108YYC ycei family GTH21_RS12720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GTH21_RS12725 ENOG4108W5H UPF0263 protein GTH21_RS12730 ENOG4105EYW Ion transport protein GTH21_RS12735 ENOG4108JQ7 (ABC) transporter GTH21_RS12740 ENOG4105C3U ABC transporter GTH21_RS12745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GTH21_RS12750 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GTH21_RS12755 ENOG4108J59 Extracellular solute-binding protein, family 5 GTH21_RS12765 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GTH21_RS12775 ENOG4105C0A alcohol dehydrogenase GTH21_RS12780 ENOG4107104 thymidine kinase GTH21_RS12795 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GTH21_RS12800 ENOG4105I93 response regulator GTH21_RS12805 ENOG4105D78 K07001 NTE family protein GTH21_RS12815 ENOG4105CIY formyltetrahydrofolate deformylase GTH21_RS12860 ENOG41076YT nitrate reductase, gamma subunit GTH21_RS12865 ENOG4105R3A Nitrate reductase GTH21_RS12870 ENOG4108IUE nitrate reductase beta subunit GTH21_RS12875 ENOG4105CRU nitrate reductase, alpha subunit GTH21_RS12885 ENOG4105DQQ Major facilitator superfamily MFS_1 GTH21_RS12890 ENOG4105BZU Histidine kinase GTH21_RS12895 ENOG4105WH1 Two component transcriptional regulator luxr family GTH21_RS12900 ENOG4105ID0 Putative invasin GTH21_RS12910 ENOG4107QZF nitrite reductase NADPH large subunit GTH21_RS12915 ENOG4105D7T ABC transporter GTH21_RS12925 ENOG4105I5W Transporter GTH21_RS12940 ENOG41090EX DsrE family GTH21_RS12950 ENOG4108NH8 Cation transport protein GTH21_RS12955 ENOG4105WS7 Cation transport regulator GTH21_RS12960 ENOG4105EWV Sodium calcium exchanger membrane region GTH21_RS12965 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GTH21_RS12970 ENOG41063JG Transcriptional regulator GTH21_RS12975 ENOG4108YY7 Invasion gene expression up-regulator SirB GTH21_RS12980 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GTH21_RS12985 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GTH21_RS12990 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GTH21_RS12995 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GTH21_RS13000 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GTH21_RS13005 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GTH21_RS13010 ENOG4105CHH sulfate transporter GTH21_RS13020 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria GTH21_RS13025 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GTH21_RS13030 ENOG4105C3G gtp-binding protein GTH21_RS13115 ENOG4106678 morphogenetic protein associated with SpoVID GTH21_RS13130 ENOG4108ZG0 Ompa motb domain protein GTH21_RS13155 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GTH21_RS13160 ENOG4105D3G Pseudouridine synthase GTH21_RS13170 ENOG4105F04 LysR family Transcriptional regulator GTH21_RS13180 ENOG4105CSH Transporter GTH21_RS13200 ENOG4107YNJ LysR family Transcriptional regulator GTH21_RS13205 ENOG4108IV0 ABC, transporter GTH21_RS13210 ENOG4105C0Z ABC transporter GTH21_RS13215 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GTH21_RS13220 ENOG4105C32 Amino acid ABC transporter (Permease) GTH21_RS13235 ENOG4105C6N Formate acetyltransferase GTH21_RS13245 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) GTH21_RS13250 ENOG4105C7B Threonine dehydratase GTH21_RS13255 ENOG410811B TRANSCRIPTIONal GTH21_RS13310 ENOG4105E0K tonB-dependent siderophore receptor GTH21_RS13315 ENOG4106JQ5 Transglycosylase SLT domain GTH21_RS13320 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GTH21_RS13325 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GTH21_RS13335 ENOG4105MWK D-amino acid dehydrogenase, small subunit GTH21_RS13345 ENOG4105ED1 spovr family GTH21_RS13350 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GTH21_RS13355 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GTH21_RS13360 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GTH21_RS13370 ENOG4108ZZ3 UPF0260 protein GTH21_RS13375 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GTH21_RS13380 ENOG4105VNG YcgL domain-containing protein GTH21_RS13385 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GTH21_RS13390 ENOG4107QMS site-determining protein GTH21_RS13395 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GTH21_RS13400 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GTH21_RS13405 ENOG4105CEY Amp-dependent synthetase and ligase GTH21_RS13410 ENOG4105Y4Z Outer Membrane Lipoprotein GTH21_RS13415 ENOG41072GX Peptidase M22 Glycoprotease GTH21_RS13420 ENOG4105DVT helicase GTH21_RS13425 ENOG4105M4H endoribonuclease L-psp GTH21_RS13430 ENOG4105X5C UPF0181 protein GTH21_RS13440 ENOG4105P8F nudix hydrolase GTH21_RS13445 ENOG4105EJQ L-serine dehydratase GTH21_RS13455 ENOG4107XTP (EAL) domain protein GTH21_RS13460 ENOG4105EE5 Membrane protein terC GTH21_RS13465 ENOG4105DAS pts system GTH21_RS13470 ENOG4105ETZ PTS System GTH21_RS13475 ENOG4105F3R pts system mannose fructose sorbose family iid GTH21_RS13480 ENOG4108NK4 UPF0266 membrane protein GTH21_RS13485 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) GTH21_RS13490 ENOG4105DHI Methyltransferase GTH21_RS13495 ENOG4105CJN penicillin-binding protein GTH21_RS13515 ENOG4105Q3Y exported protein GTH21_RS13525 ENOG4105TIK GTH21_RS13530 ENOG4105J4Q Transcriptional regulator GTH21_RS13535 ENOG4105C0R drug resistance transporter emrb qaca subfamily GTH21_RS13540 ENOG4105D0M Protease HtpX homolog GTH21_RS13545 ENOG4105CN1 protease GTH21_RS13550 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GTH21_RS13555 ENOG4108ZGC gaf domain protein GTH21_RS13560 ENOG4105H2K paraquat-inducible protein a GTH21_RS13565 ENOG4105DY2 Paraquat-inducible protein b GTH21_RS13570 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GTH21_RS13575 ENOG4105WT8 Protein of unknown function (DUF1480) GTH21_RS13580 ENOG4105UVW uncharacterized protein yebW GTH21_RS13585 ENOG4108R1E Serine threonine protein phosphatase 1 GTH21_RS13590 ENOG4108MJ5 VirK protein GTH21_RS13600 ENOG4105NKT exported protein GTH21_RS13605 ENOG4108PNC copper resistance GTH21_RS13610 ENOG4105FXM Copper resistance protein GTH21_RS13615 ENOG4105MPK DNA polymerase III subunit theta GTH21_RS13620 ENOG4105UMD exodeoxyribonuclease X GTH21_RS13625 ENOG4105CUG Oligopeptidase b GTH21_RS13630 ENOG4108Q2J Inner membrane protein YebE GTH21_RS13635 ENOG4105X2V dna damage-inducible protein GTH21_RS13645 ENOG4108UHU Aldolase GTH21_RS13650 ENOG4105C01 Dihydroxy-acid dehydratase GTH21_RS13655 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GTH21_RS13665 ENOG4106KNT transcriptional regulator GTH21_RS13670 ENOG4105CA9 Pyruvate kinase GTH21_RS13675 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GTH21_RS13680 ENOG4105DR5 peptidase GTH21_RS13685 ENOG4105NXV High-affinity zinc uptake system protein GTH21_RS13695 ENOG4105FAV ABC, transporter GTH21_RS13700 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GTH21_RS13705 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GTH21_RS13710 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GTH21_RS13715 ENOG4105CDY transcriptional regulatory protein GTH21_RS13720 ENOG4108TIT dATP pyrophosphohydrolase GTH21_RS13725 ENOG4105C9M aspartyl-trna synthetase GTH21_RS13730 ENOG4105D3W isochorismatase GTH21_RS13735 ENOG41081XQ Conserved Protein GTH21_RS13740 ENOG4105WJG Glutathione GTH21_RS13745 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GTH21_RS13750 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GTH21_RS13755 ENOG4106N3A copper homeostasis protein cutc GTH21_RS13760 ENOG4106ZCM YecM protein GTH21_RS13765 ENOG4105C75 arginyL-tRNA synthetase GTH21_RS13770 ENOG4105F5H Glycosyl Hydrolase Family 88 GTH21_RS13775 ENOG4105CT4 transporter GTH21_RS13780 ENOG4108VA4 Universal stress protein GTH21_RS13785 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GTH21_RS13795 ENOG4105CNN ABC, transporter GTH21_RS13805 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GTH21_RS13815 ENOG4108UEC Ferritin-like protein GTH21_RS13830 ENOG4105N4N Protein of unknown function (DUF2766) GTH21_RS13835 ENOG4105C0R drug resistance transporter emrb qaca subfamily GTH21_RS13850 ENOG41090A1 ferritin GTH21_RS13855 ENOG4105VVZ metal-binding protein GTH21_RS13860 ENOG4105E0U tyrosine-specific transport protein GTH21_RS13865 ENOG4106RHG Yeca family GTH21_RS13900 ENOG4105WH1 Two component transcriptional regulator luxr family GTH21_RS13905 ENOG4105XVG cytoplasmic protein GTH21_RS13910 ENOG4105VJY transcriptional regulator GTH21_RS13915 ENOG4105CDA abc transporter atp-binding protein GTH21_RS13920 ENOG4105E5Q amino acid AbC transporter GTH21_RS13925 ENOG4105K6H D-cysteine desulfhydrase GTH21_RS13930 ENOG4105EAB amino acid AbC transporter GTH21_RS13935 ENOG4105E5K Alpha-amylase GTH21_RS13940 ENOG4105JCU Inherit from NOG: (Lipo)protein GTH21_RS13955 ENOG4105YX3 cellular response to acidity GTH21_RS13965 ENOG4105CKW Inner membrane protein yedI GTH21_RS13970 ENOG4105FDR Membrane GTH21_RS13975 ENOG41090BB DNA mismatch endonuclease (vsr) GTH21_RS13980 ENOG4105DVF Cytosine-specific methyltransferase GTH21_RS13985 ENOG4105EST Metal Dependent Phosphohydrolase GTH21_RS13990 ENOG4105Y0K Inner membrane protein YedR GTH21_RS14000 ENOG4105FCK Membrane GTH21_RS14010 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) GTH21_RS14030 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GTH21_RS14035 ENOG4107R11 Transcriptional regulator GTH21_RS14055 ENOG4105EEQ Na H antiporter GTH21_RS14060 ENOG4108WUH Transcriptional regulator, TetR family GTH21_RS14065 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GTH21_RS14085 ENOG4105FYV Amp nucleosidase GTH21_RS14095 ENOG4105UQX Mate efflux family protein GTH21_RS14120 ENOG4105BZU Histidine kinase GTH21_RS14135 ENOG4105ETT transcriptional Regulator, LysR family GTH21_RS14140 ENOG4105YP6 Domain of unknown function (DUF1869) GTH21_RS14145 ENOG4108YS1 cytoplasmic protein GTH21_RS14155 ENOG4105BZU Histidine kinase GTH21_RS14165 ENOG4105CSH Transporter GTH21_RS14170 ENOG4108KMH lipoate-protein ligase a GTH21_RS14175 ENOG4105HEI LysR family (Transcriptional regulator GTH21_RS14180 ENOG41090U3 tautomerase GTH21_RS14190 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GTH21_RS14195 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GTH21_RS14200 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GTH21_RS14205 ENOG41090HJ UPF0265 protein GTH21_RS14210 ENOG4105DR8 Membrane GTH21_RS14220 ENOG4105DZ1 carboxypeptidase GTH21_RS14225 ENOG4105CJB Exodeoxyribonuclease I GTH21_RS14230 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GTH21_RS14235 ENOG4105YVS arsR family transcriptional regulator GTH21_RS14240 ENOG4105CUB amino acid GTH21_RS14250 ENOG4105EQ1 Transcriptional regulator GTH21_RS14255 ENOG4107SRH Nad-dependent epimerase dehydratase GTH21_RS14265 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GTH21_RS14275 ENOG4105CIH Imidazole acetol-phosphate transaminase GTH21_RS14280 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GTH21_RS14285 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GTH21_RS14295 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GTH21_RS14300 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GTH21_RS14325 ENOG4105CPK Glycosyl transferase (Group 1 GTH21_RS14370 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GTH21_RS14375 ENOG4105PSV Polysaccharide Biosynthesis Protein GTH21_RS14390 ENOG4105CG5 Glycosyl transferase (Group 1 GTH21_RS14400 ENOG4108RYC glycosyltransferase GTH21_RS14405 ENOG4105K64 Glycosyl transferase, family 2 GTH21_RS14415 ENOG4105D3Q Sugar transferase GTH21_RS14430 ENOG4105DAY polysaccharide export protein GTH21_RS14435 ENOG4108MRJ GTH21_RS14445 ENOG4105MH5 phosphoesterase PA-phosphatase related protein GTH21_RS14450 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GTH21_RS14455 ENOG4105EE5 Membrane protein terC GTH21_RS14460 ENOG4108GAE asmA family GTH21_RS14465 ENOG4105DHP deoxycytidine triphosphate deaminase GTH21_RS14470 ENOG4105DBI uridine monophosphokinase GTH21_RS14475 ENOG4105D03 DNA-3-methyladenine glycosylase II GTH21_RS14480 ENOG4105R8A Heat shock protein GTH21_RS14485 ENOG4105BZU Histidine kinase GTH21_RS14505 ENOG4105CK2 sodium dicarboxylate symporter GTH21_RS14510 ENOG4105ENT Efflux transporter rnd family, mfp subunit GTH21_RS14515 ENOG4105BZS acriflavin resistance protein GTH21_RS14520 ENOG4105BZS acriflavin resistance protein GTH21_RS14525 ENOG4105C0R drug resistance transporter emrb qaca subfamily GTH21_RS14530 ENOG4105EB3 Histidine kinase GTH21_RS14535 ENOG4105E3W Two component transcriptional regulator (Winged helix family GTH21_RS14540 ENOG4105CFP Peptidase U32 GTH21_RS14550 ENOG4108JQ7 (ABC) transporter GTH21_RS14560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GTH21_RS14565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GTH21_RS14570 ENOG4105DEF Extracellular solute-binding protein, family 5 GTH21_RS14575 ENOG4105CXK mandelate racemase muconate lactonizing GTH21_RS14580 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GTH21_RS14585 ENOG4105IE8 Alpha-ketoglutarate permease GTH21_RS14590 ENOG4105CMG Carbohydrate kinase GTH21_RS14595 ENOG4105DEI Mannitol dehydrogenase GTH21_RS14620 ENOG4105IE8 Alpha-ketoglutarate permease GTH21_RS14625 ENOG4105EIE fructose-bisphosphate aldolase GTH21_RS14630 ENOG4105DWF phosphomethylpyrimidine kinase GTH21_RS14645 ENOG4105DUM transcriptional regulator, lysR family GTH21_RS14650 ENOG4105CPN adenine deaminase GTH21_RS14655 ENOG4105C7N Xanthine uracil vitamin C permease GTH21_RS14660 ENOG4105EJC lysr family transcriptional regulator GTH21_RS14665 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly GTH21_RS14675 ENOG4105D1F ATP-binding protein GTH21_RS14680 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GTH21_RS14685 ENOG4108W15 Protein of unknown function (DUF1456) GTH21_RS14690 ENOG4108NEV two component transcriptional regulator, LytTR family GTH21_RS14695 ENOG4108HRK Histidine kinase GTH21_RS14705 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component GTH21_RS14710 ENOG4108IJ8 ABC transporter GTH21_RS14715 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GTH21_RS14720 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GTH21_RS14725 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GTH21_RS14730 ENOG4105CXG d-lactate dehydrogenase GTH21_RS14740 ENOG41061WM D-Alanyl-D-Alanine GTH21_RS14745 ENOG41069YE inner membrane protein yohC GTH21_RS14750 ENOG4105KHU inner membrane protein YohD GTH21_RS14765 ENOG4105CS2 ec 3.2.1.21 GTH21_RS14780 ENOG4105TW1 Carbohydrate-selective porin OprB GTH21_RS14785 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GTH21_RS14790 ENOG4105VAW lrga family GTH21_RS14795 ENOG41067MG lrgb family GTH21_RS14800 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GTH21_RS14805 ENOG4107GZ4 SanA protein GTH21_RS14810 ENOG4107SDZ Galactoside transport system permease protein mglC GTH21_RS14815 ENOG4105C2J ABC transporter GTH21_RS14825 ENOG41060NJ transcriptional regulator GTH21_RS14830 ENOG4105DHF Membrane GTH21_RS14835 ENOG4105EUJ GTP cyclohydrolase i GTH21_RS14845 ENOG4105D05 Receptor GTH21_RS14850 ENOG4108IQI permease GTH21_RS14855 ENOG4105DUM transcriptional regulator, lysR family GTH21_RS14860 ENOG4105HMI Membrane GTH21_RS14865 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GTH21_RS14870 ENOG4105DM4 PTS System GTH21_RS14875 ENOG4105DE4 1-phosphofructokinase GTH21_RS14880 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GTH21_RS14885 ENOG4105S8Q sugar efflux transporter GTH21_RS14890 ENOG4105KRS Proteinase inhibitor GTH21_RS14900 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GTH21_RS14905 ENOG4105DEI Mannitol dehydrogenase GTH21_RS14910 ENOG4105CKI cobalamin synthesis protein GTH21_RS14915 ENOG41076MN Phosphoesterase, PA-phosphatase related GTH21_RS14920 ENOG4107TT5 NLP P60 protein GTH21_RS14925 ENOG4105CXC rtn protein GTH21_RS14930 ENOG4105E43 Extracellular solute-binding protein, family 5 GTH21_RS14935 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GTH21_RS14940 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GTH21_RS14945 ENOG4108JQ5 ABC transporter GTH21_RS14950 ENOG4105HG6 GTH21_RS14955 ENOG4105C2C drug resistance transporter, Bcr CflA GTH21_RS14960 ENOG4105I08 Pseudouridine synthase GTH21_RS14965 ENOG4105CFI type iii restriction protein res subunit GTH21_RS14970 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GTH21_RS14985 ENOG4107VIJ nudix hydrolase GTH21_RS14990 ENOG4105N2W Transcriptional regulator GTH21_RS14995 ENOG4106V8H Nucleoid-associated protein GTH21_RS15000 ENOG4105PAN UPF0352 protein GTH21_RS15005 ENOG4105E68 Sulfatase GTH21_RS15015 ENOG4105F4G Membrane GTH21_RS15030 ENOG4105CHH sulfate transporter GTH21_RS15035 ENOG4105CJW magnesium transporter GTH21_RS15040 ENOG4105IBP Cyclic peptide transporter GTH21_RS15045 ENOG4105CF1 Alkylated DNA repair protein GTH21_RS15050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GTH21_RS15065 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GTH21_RS15070 ENOG41068CG regulatoR GTH21_RS15075 ENOG4105BZU Histidine kinase GTH21_RS15080 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GTH21_RS15085 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GTH21_RS15090 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GTH21_RS15095 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GTH21_RS15100 ENOG4105XPH Ferredoxin GTH21_RS15105 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GTH21_RS15110 ENOG4105CXY transporter GTH21_RS15115 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GTH21_RS15120 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B GTH21_RS15125 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GTH21_RS15130 ENOG4105CNV Aldolase GTH21_RS15135 ENOG4105CSP Major Facilitator Superfamily GTH21_RS15150 ENOG4105CXK mandelate racemase muconate lactonizing GTH21_RS15155 ENOG4107258 Transcriptional regulator GTH21_RS15160 ENOG4108EWA cinA-like protein GTH21_RS15165 ENOG4108UII YfaZ family GTH21_RS15175 ENOG4105DNE Transposase GTH21_RS15185 ENOG4105CEY Amp-dependent synthetase and ligase GTH21_RS15190 ENOG4105DNI Converts SHCHC to OSB (By similarity) GTH21_RS15195 ENOG4108IPT Naphthoate synthase GTH21_RS15200 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GTH21_RS15205 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GTH21_RS15210 ENOG4105E4F Isochorismate synthase GTH21_RS15215 ENOG4107YB6 acetyltransferase, (GNAT) family GTH21_RS15220 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GTH21_RS15225 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GTH21_RS15230 ENOG4105C8S subunit m GTH21_RS15235 ENOG4105D65 subunit l GTH21_RS15240 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GTH21_RS15245 ENOG4107UFS subunit j GTH21_RS15255 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GTH21_RS15260 ENOG4108IEH NADH dehydrogenase subunit g GTH21_RS15265 ENOG4107QIZ NADH dehydrogenase GTH21_RS15270 ENOG4105GKE subunit e GTH21_RS15275 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GTH21_RS15280 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GTH21_RS15285 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GTH21_RS15295 ENOG4107NQ8 LysR family Transcriptional regulator GTH21_RS15300 ENOG4105CHM Aminotransferase GTH21_RS15305 ENOG4105DK2 UPF0207 protein GTH21_RS15310 ENOG4107QWE )-transporter GTH21_RS15315 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GTH21_RS15325 ENOG4105PQ6 UPF0208 membrane protein GTH21_RS15330 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GTH21_RS15335 ENOG4105C6K Malic enzyme GTH21_RS15340 ENOG4105PTV Nudix Hydrolase GTH21_RS15345 ENOG4108RE9 Phosphodiesterase GTH21_RS15350 ENOG4108SHQ Glutathione S-transferase GTH21_RS15355 ENOG4105CYM Glutathione S-transferase GTH21_RS15360 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase GTH21_RS15365 ENOG4105ECP epimerase GTH21_RS15375 ENOG4105KNA -acetyltransferase GTH21_RS15380 ENOG4108JEH abc transporter atp-binding protein GTH21_RS15385 ENOG4106YG3 ABC transporter GTH21_RS15390 ENOG4105DSP amino acid AbC transporter GTH21_RS15395 ENOG4105E89 ABC transporter GTH21_RS15400 ENOG4105E89 ABC transporter GTH21_RS15410 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GTH21_RS15415 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GTH21_RS15420 ENOG4105E96 Colicin v production protein GTH21_RS15425 ENOG4108S3P Sporulation domain protein GTH21_RS15430 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GTH21_RS15435 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GTH21_RS15440 ENOG4105DQR SNARE associated Golgi GTH21_RS15445 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GTH21_RS15450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GTH21_RS15460 ENOG4106WZ1 flagella biosynthesis regulator GTH21_RS15465 ENOG4105F9N Major Facilitator Superfamily GTH21_RS15470 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GTH21_RS15475 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GTH21_RS15480 ENOG4105MH2 YfcL protein GTH21_RS15485 ENOG4108BPE -transporting atpase GTH21_RS15490 ENOG4105EJ9 Membrane GTH21_RS15495 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) GTH21_RS15500 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GTH21_RS15505 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GTH21_RS15510 ENOG4108DG9 Smr protein MutS2 GTH21_RS15515 ENOG4108BY2 phosphohistidine phosphatase GTH21_RS15520 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GTH21_RS15525 ENOG4105CHU acetyl-coa acetyltransferase GTH21_RS15530 ENOG4105KZW UPF0381 protein GTH21_RS15535 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GTH21_RS15540 ENOG410903C (LipO)protein GTH21_RS15545 ENOG4105S64 Formate nitrite transporter GTH21_RS15615 ENOG4105DND Transcriptional regulator GTH21_RS15620 ENOG4107Y2X deaminase GTH21_RS15625 ENOG4105DJ2 Major Facilitator Superfamily GTH21_RS15635 ENOG4105CHM Aminotransferase GTH21_RS15650 ENOG4108HRK Histidine kinase GTH21_RS15655 ENOG4105DY9 regulatoR GTH21_RS15660 ENOG4105CHC glucokinase (EC 2.7.1.2) GTH21_RS15670 ENOG4107RA9 decarboxylase GTH21_RS15675 ENOG4105CPC Aldo Keto reductase GTH21_RS15680 ENOG4109076 Conserved Protein GTH21_RS15685 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GTH21_RS15690 ENOG4105D9N nucleoside GTH21_RS15695 ENOG4108KMM Diguanylate cyclase GTH21_RS15710 ENOG4105HZG regulatoR GTH21_RS15715 ENOG4105GXM Putative transcription regulator (DUF1323) GTH21_RS15720 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GTH21_RS15745 ENOG4108M0I Transcriptional regulator GTH21_RS15750 ENOG4105DHU Bile acid GTH21_RS15755 ENOG4105VRT cytoplasmic protein GTH21_RS15760 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GTH21_RS15765 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GTH21_RS15770 ENOG4105EXN Sulfate transport protein CysZ GTH21_RS15775 ENOG4105C6T cysteine synthase GTH21_RS15785 ENOG4105KZ7 phosphocarrier protein hpr GTH21_RS15790 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GTH21_RS15795 ENOG4105C5Y PTS System GTH21_RS15805 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GTH21_RS15810 ENOG4105CSW GntR family transcriptional regulator GTH21_RS15815 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein GTH21_RS15820 ENOG4105C6T cysteine synthase GTH21_RS15825 ENOG4108IJ6 ABC transporter GTH21_RS15830 ENOG4105ECW sulfate abc transporter GTH21_RS15835 ENOG4108I5D sulfate abc transporter GTH21_RS15840 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GTH21_RS15850 ENOG4105EZR dyp-type peroxidase family protein GTH21_RS15855 ENOG4105E7K (LipO)protein GTH21_RS15860 ENOG4105QZU Inner membrane protein YfeZ GTH21_RS15865 ENOG4108R6G acetyltransferase GTH21_RS15870 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase GTH21_RS15875 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GTH21_RS15880 ENOG4108K3Z AraC family transcriptional regulator GTH21_RS15885 ENOG4108X49 Ethanolamine utilization protein EutK GTH21_RS15890 ENOG4106D67 ethanolamine utilization protein GTH21_RS15900 ENOG4105CPD ethanolamine ammonia-lyase GTH21_RS15905 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase GTH21_RS15910 ENOG4105ENY Ethanolamine utilization protein eutH GTH21_RS15915 ENOG4105C0A alcohol dehydrogenase GTH21_RS15920 ENOG4107YMV ethanolamine utilization protein GTH21_RS15925 ENOG4108EKI Dehydrogenase GTH21_RS15930 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GTH21_RS15935 ENOG4105KNY Microcompartments protein GTH21_RS15940 ENOG4108IJ2 phosphate acetyltransferase GTH21_RS15945 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase GTH21_RS15950 ENOG4105NDK ethanolamine utilization protein GTH21_RS15955 ENOG4106S4J ethanolamine utilization protein EutP GTH21_RS15960 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place GTH21_RS15965 ENOG4105C6K Malic enzyme GTH21_RS15970 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GTH21_RS15975 ENOG4105CV1 Transketolase (EC 2.2.1.1) GTH21_RS15980 ENOG4108PVD exported protein GTH21_RS15985 ENOG4107VIJ nudix hydrolase GTH21_RS15990 ENOG4105BZ8 glutamate synthase GTH21_RS15995 ENOG4105BZS acriflavin resistance protein GTH21_RS16005 ENOG4105KUZ arsenate reductase GTH21_RS16010 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GTH21_RS16015 ENOG4105XYK UPF0370 protein GTH21_RS16020 ENOG4106KED esterase YpfH GTH21_RS16025 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GTH21_RS16030 ENOG4105CGZ zinc metallopeptidase GTH21_RS16035 ENOG4105C8V SAICAR synthetase GTH21_RS16040 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GTH21_RS16045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GTH21_RS16050 ENOG4105RH4 Glycine cleavage system transcriptional repressor GTH21_RS16055 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GTH21_RS16060 ENOG4105C02 permease GTH21_RS16070 ENOG4105ERG peptidase m48, ste24p GTH21_RS16075 ENOG4105K89 arsenate reductase GTH21_RS16085 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) GTH21_RS16090 ENOG4105C2W permease GTH21_RS16095 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GTH21_RS16100 ENOG4105CS2 ec 3.2.1.21 GTH21_RS16105 ENOG41066F8 ROK family GTH21_RS16110 ENOG4105CXB phosphoribosylaminoimidazole synthetase GTH21_RS16115 ENOG4108V3E phosphoribosylglycinamide formyltransferase GTH21_RS16120 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GTH21_RS16125 ENOG4105C9X ppx gppa phosphatase GTH21_RS16130 ENOG4105BZU Histidine kinase GTH21_RS16135 ENOG41062G3 Protein of unknown function (DUF2633) GTH21_RS16150 ENOG4105C4X radical SAM domain protein GTH21_RS16160 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GTH21_RS16165 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GTH21_RS16170 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GTH21_RS16175 ENOG4105VPD cellular component movement GTH21_RS16185 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GTH21_RS16190 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GTH21_RS16195 ENOG4105N21 Membrane GTH21_RS16205 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GTH21_RS16210 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) GTH21_RS16215 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GTH21_RS16220 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GTH21_RS16225 ENOG4108JQB penicillin-binding protein 1C GTH21_RS16230 ENOG4105DN3 alpha-2-macroglobulin domain protein GTH21_RS16235 ENOG4105KHC sulfurtransferase GTH21_RS16245 ENOG4105YYA enhanced serine sensitivity protein SseB GTH21_RS16250 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GTH21_RS16255 ENOG4105WVQ Fe-S assembly protein IscX GTH21_RS16260 ENOG4108ZIT Ferredoxin, 2FE-2S GTH21_RS16265 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GTH21_RS16270 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) GTH21_RS16275 ENOG4108Z4V iron-sulfur cluster assembly GTH21_RS16280 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GTH21_RS16285 ENOG4105C3J Cysteine desulfurase GTH21_RS16290 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GTH21_RS16295 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GTH21_RS16300 ENOG4105ECY inositol monophosphatase GTH21_RS16310 ENOG4105D7X high-affinity nickel-transporter GTH21_RS16315 ENOG41065CD Exported protein GTH21_RS16320 ENOG4108MN2 Stationary phase inducible protein CsiE GTH21_RS16325 ENOG4105D8G Major Facilitator superfamily GTH21_RS16330 ENOG4108ZKT aldose 1-epimerase GTH21_RS16335 ENOG4107QNK )-transporter GTH21_RS16340 ENOG4107HQ7 repeat protein GTH21_RS16345 ENOG4108NZE NAGC-like transcriptional regulator GTH21_RS16350 ENOG4108SB3 DoxX Family GTH21_RS16355 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GTH21_RS16360 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GTH21_RS16365 ENOG4108YZA Nitrogen regulatory protein pii GTH21_RS16370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GTH21_RS16375 ENOG4108SKK alpha helix protein GTH21_RS16380 ENOG4107WP9 Histidine kinase GTH21_RS16385 ENOG4108ETH Formylglycinamide ribotide synthetase GTH21_RS16390 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GTH21_RS16395 ENOG4108Z6B deaminase GTH21_RS16400 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB GTH21_RS16405 ENOG4106G6Q Transcriptional regulator GTH21_RS16410 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GTH21_RS16415 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GTH21_RS16420 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GTH21_RS16425 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GTH21_RS16430 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GTH21_RS16435 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GTH21_RS16440 ENOG4105C3F Signal peptidase i GTH21_RS16445 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GTH21_RS16450 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GTH21_RS16455 ENOG4105VQK sigma E regulatory protein, MucB RseB GTH21_RS16460 ENOG41069PW sigma-e factor negative regulatory protein GTH21_RS16475 ENOG4108IYU L-aspartate oxidase GTH21_RS16480 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GTH21_RS16485 ENOG4105C1J atp-dependent rna helicase GTH21_RS16490 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GTH21_RS16495 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GTH21_RS16500 ENOG4105EIB trna rrna methyltransferase GTH21_RS16505 ENOG4105K63 Thioredoxin GTH21_RS16510 ENOG4106IUH DTW domain containing protein GTH21_RS16515 ENOG4105CD5 CoA-binding domain protein GTH21_RS16520 ENOG4105JIM Phosphatidylserine synthase GTH21_RS16525 ENOG4105T42 (LipO)protein GTH21_RS16530 ENOG4105CSH Transporter GTH21_RS16555 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GTH21_RS16560 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GTH21_RS16565 ENOG4105C34 Pseudouridine synthase GTH21_RS16570 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GTH21_RS16575 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GTH21_RS16585 ENOG4105CQC Prephenate dehydratase GTH21_RS16595 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GTH21_RS16600 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GTH21_RS16605 ENOG4108WS1 GTH21_RS16610 ENOG4108KHX Diguanylate cyclase GTH21_RS16615 ENOG41090EK ompa motb domain protein GTH21_RS16690 ENOG4105VZ1 Replication Protein GTH21_RS16710 ENOG4105ED4 portal protein GTH21_RS16840 ENOG4105ZTC transcriptional activator, Ogr delta GTH21_RS16845 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GTH21_RS16850 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GTH21_RS16855 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GTH21_RS16860 ENOG4105K5M 30s ribosomal protein S16 GTH21_RS16865 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GTH21_RS16870 ENOG4106KVJ cytochrome C assembly protein GTH21_RS16875 ENOG4108JU6 CBS domain protein GTH21_RS16880 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GTH21_RS16885 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GTH21_RS16890 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GTH21_RS16900 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GTH21_RS16910 ENOG4108Z1B Cyclase dehydrase GTH21_RS16915 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GTH21_RS16940 ENOG4105UEI Transcriptional Regulator AraC Family GTH21_RS16945 ENOG4105C1P efflux transporter, rnd family, mfp subunit GTH21_RS16960 ENOG4105EVZ LysR family transcriptional regulator GTH21_RS16965 ENOG4105CYW agmatinase GTH21_RS16980 ENOG4106TNF Periplasmic binding protein GTH21_RS16990 ENOG4105MP9 class II Aldolase GTH21_RS16995 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GTH21_RS17000 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GTH21_RS17015 ENOG4108WQH regulatoR GTH21_RS17020 ENOG4106EAR Fimbrial protein GTH21_RS17025 ENOG4106P2F Pfam:Pili_assembly_C GTH21_RS17030 ENOG4105CW0 outer membrane usher protein GTH21_RS17045 ENOG4105CW0 outer membrane usher protein GTH21_RS17055 ENOG4105X0I Fimbrial GTH21_RS17060 ENOG4105C26 Dehydrogenase GTH21_RS17065 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GTH21_RS17070 ENOG4105CC0 LysR family Transcriptional regulator GTH21_RS17080 ENOG41080HT Transcriptional regulator, arsr family GTH21_RS17085 ENOG4108V62 Rhodanese domain protein GTH21_RS17100 ENOG4108X73 DNA- binding protein GTH21_RS17110 ENOG4108RNS Exports L-alanine (By similarity) GTH21_RS17115 ENOG4108WMJ Protein of unknown function (DUF2002) GTH21_RS17120 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) GTH21_RS17125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GTH21_RS17130 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GTH21_RS17135 ENOG4105WAZ (Glutaredoxin-like protein) NrdH GTH21_RS17140 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GTH21_RS17145 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GTH21_RS17150 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GTH21_RS17155 ENOG4108IJ7 Glycine betaine GTH21_RS17160 ENOG4108HQS Glycine betaine GTH21_RS17165 ENOG4105GIJ Glycine betaine GTH21_RS17170 ENOG4108UMN azlc family GTH21_RS17175 ENOG4105ZED uncharacterized protein ygaH GTH21_RS17185 ENOG4105NTK Transcriptional repressor Mpra GTH21_RS17195 ENOG4105CW7 secretion protein, HlyD family GTH21_RS17200 ENOG4105C0R drug resistance transporter emrb qaca subfamily GTH21_RS17205 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GTH21_RS17220 ENOG4105D9M gamma-glutamylcysteine synthetase GTH21_RS17225 ENOG4105W39 Membrane GTH21_RS17230 ENOG4107VXZ Hydrolase GTH21_RS17235 ENOG4105K3G Periplasmic Protein GTH21_RS17270 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GTH21_RS17275 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GTH21_RS17280 ENOG4105Y3E Modulates RecA activity (By similarity) GTH21_RS17285 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GTH21_RS17290 ENOG4107TH8 cina domain protein GTH21_RS17295 ENOG4105DSE periplasmic solute binding protein GTH21_RS17300 ENOG4105CC5 ABC transporter GTH21_RS17310 ENOG4105CVE Lytic murein transglycosylase GTH21_RS17315 ENOG410787A Pts system, glucitol sorbitol-specific GTH21_RS17320 ENOG4105DZY Pts system, glucitol sorbitol-specific GTH21_RS17325 ENOG4105VI0 Pts system, glucitol sorbitol-specific GTH21_RS17330 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GTH21_RS17335 ENOG4105J92 DNA-binding transcriptional activator GutM GTH21_RS17340 ENOG410804X Transcriptional regulator GTH21_RS17350 ENOG4108JUA Transcriptional regulator GTH21_RS17360 ENOG4105CNW domain protein GTH21_RS17365 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase GTH21_RS17375 ENOG4105C8H hydrogenase maturation protein Hypf GTH21_RS17380 ENOG4108RC0 Electron transport protein GTH21_RS17385 ENOG4105DDV Transcriptional regulator (LacI family GTH21_RS17395 ENOG4105C5Y PTS System GTH21_RS17400 ENOG4105CS2 ec 3.2.1.21 GTH21_RS17410 ENOG4108MG9 hydrogenase 3 maturation protease GTH21_RS17415 ENOG4105I6X formate hydrogenlyase maturation GTH21_RS17420 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GTH21_RS17425 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit GTH21_RS17430 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GTH21_RS17435 ENOG4107TDF Formate hydrogenlyase subunit 4 GTH21_RS17440 ENOG4107R30 NADH dehydrogenase GTH21_RS17445 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) GTH21_RS17450 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA GTH21_RS17455 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GTH21_RS17460 ENOG4107RSS Hydrogenase accessory protein HypB GTH21_RS17465 ENOG41083WG hydrogenase assembly chaperone GTH21_RS17470 ENOG4105CQS hydrogenase expression formation protein HypD GTH21_RS17475 ENOG4105C45 hydrogenase expression formation protein (HypE) GTH21_RS17485 ENOG4105CS2 ec 3.2.1.21 GTH21_RS17495 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GTH21_RS17500 ENOG4105CK1 PTS System GTH21_RS17505 ENOG4105VZJ PTS System GTH21_RS17510 ENOG4105CK1 PTS System GTH21_RS17515 ENOG4105VCP PTS System GTH21_RS17520 ENOG4105DKQ ROK family GTH21_RS17525 ENOG4105DDV Transcriptional regulator (LacI family GTH21_RS17530 ENOG4105DSE periplasmic solute binding protein GTH21_RS17535 ENOG4105DIK (ABC) transporter GTH21_RS17540 ENOG4105CC5 ABC transporter GTH21_RS17545 ENOG4105CC5 ABC transporter GTH21_RS17550 ENOG4105VXR cytoplasmic protein GTH21_RS17560 ENOG4108N2Y auxin Efflux GTH21_RS17580 ENOG4106QJH hemin transport protein GTH21_RS17585 ENOG4107R4I Periplasmic binding protein GTH21_RS17590 ENOG4105EHG Permease protein GTH21_RS17595 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS17615 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GTH21_RS17625 ENOG4105KZM cytoplasmic protein GTH21_RS17630 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GTH21_RS17635 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GTH21_RS17660 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GTH21_RS17665 ENOG4108K5P (LipO)protein GTH21_RS17670 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GTH21_RS17680 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GTH21_RS17685 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GTH21_RS17690 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GTH21_RS17695 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GTH21_RS17700 ENOG4105N0Z inner membrane protein ygbE GTH21_RS17705 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GTH21_RS17715 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GTH21_RS17720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GTH21_RS17725 ENOG4108MXK alkaline phosphatase isozyme conversion GTH21_RS17730 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GTH21_RS17735 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GTH21_RS17740 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GTH21_RS17745 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GTH21_RS17750 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GTH21_RS17765 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GTH21_RS17770 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GTH21_RS17775 ENOG4105DXN mazG family GTH21_RS17780 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GTH21_RS17785 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GTH21_RS17790 ENOG4105BZU Histidine kinase GTH21_RS17795 ENOG4105BZW Glycerate kinase GTH21_RS17800 ENOG4105EQX glucarate dehydratase GTH21_RS17805 ENOG4105EQX glucarate dehydratase GTH21_RS17810 ENOG4105DJB Major Facilitator Superfamily GTH21_RS17815 ENOG4105QDK Flavodoxin GTH21_RS17820 ENOG4105DR9 pseudouridine synthase GTH21_RS17825 ENOG4105WP7 tRNA pseudouridine synthase C GTH21_RS17830 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GTH21_RS17835 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GTH21_RS17840 ENOG4105EWT decarboxylase family GTH21_RS17845 ENOG4105C44 Serine transporter GTH21_RS17850 ENOG4105EJQ L-serine dehydratase GTH21_RS17855 ENOG4105GVF (ABC) transporter GTH21_RS17865 ENOG41079KZ Major Facilitator Superfamily GTH21_RS17870 ENOG4105D01 (LipO)protein GTH21_RS17875 ENOG4108UMI ABC transporter, permease GTH21_RS17880 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS17895 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GTH21_RS17905 ENOG4108JU7 Transcriptional regulator GTH21_RS17910 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GTH21_RS17915 ENOG4105C0A alcohol dehydrogenase GTH21_RS17920 ENOG4107W7X Aldolase GTH21_RS17930 ENOG4105EDR glucose galactose transporter GTH21_RS17935 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) GTH21_RS17940 ENOG4105CMG Carbohydrate kinase GTH21_RS17945 ENOG4105NWF RbsD or FucU transport GTH21_RS17950 ENOG4107EDW L-fucose operon activator GTH21_RS17960 ENOG4105M08 Membrane GTH21_RS17965 ENOG4105ETT transcriptional Regulator, LysR family GTH21_RS17970 ENOG4105M5B (LipO)protein GTH21_RS17975 ENOG4105C9B Cysteine desulfurase GTH21_RS17980 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GTH21_RS17985 ENOG4105CUZ uba thif-type nad fad binding protein GTH21_RS17990 ENOG4105CA3 membrane-bound lytic murein transglycosylase GTH21_RS18015 ENOG4108YZT Adenosylcobinamide kinase GTH21_RS18020 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GTH21_RS18030 ENOG4108V4M Cobalt abc transporter GTH21_RS18035 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GTH21_RS18040 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GTH21_RS18045 ENOG4105DVK Precorrin-2 c20-methyltransferase GTH21_RS18050 ENOG4107PPM cobalt chelatase GTH21_RS18055 ENOG4105QUC reductase GTH21_RS18060 ENOG4105E4R Precorrin-3B C17-methyltransferase GTH21_RS18065 ENOG4108P62 biosynthesis protein (CbiG) GTH21_RS18070 ENOG4105CIA precorrin-4 C(11)-methyltransferase GTH21_RS18075 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase GTH21_RS18080 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase GTH21_RS18085 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GTH21_RS18090 ENOG41081F0 Precorrin-8x methylmutase GTH21_RS18095 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GTH21_RS18100 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GTH21_RS18105 ENOG4107XVH Transcriptional regulator GTH21_RS18110 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GTH21_RS18115 ENOG4105KNY Microcompartments protein GTH21_RS18120 ENOG4105EHR propanediol utilization protein pduB GTH21_RS18125 ENOG4105DMB glycerol dehydratase GTH21_RS18130 ENOG4105YCI dehydratase medium subunit GTH21_RS18135 ENOG4108ZFT Dehydratase small subunit GTH21_RS18140 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit GTH21_RS18150 ENOG4105KNY Microcompartments protein GTH21_RS18155 ENOG4105KNY Microcompartments protein GTH21_RS18170 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GTH21_RS18180 ENOG4108EKI Dehydrogenase GTH21_RS18185 ENOG4105C0A alcohol dehydrogenase GTH21_RS18190 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GTH21_RS18200 ENOG4105M3W utilization protein GTH21_RS18205 ENOG4105KTW ethanolamine utilization protein GTH21_RS18210 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GTH21_RS18215 ENOG4105JZC GHMP kinase GTH21_RS18220 ENOG4107QZB decarboxylase GTH21_RS18225 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GTH21_RS18230 ENOG4107QZM n-acetylglutamate synthase GTH21_RS18240 ENOG4107QYX exodeoxyribonuclease v alpha GTH21_RS18250 ENOG4107QXK peptidase GTH21_RS18255 ENOG4105DSY exodeoxyribonuclease V, gamma GTH21_RS18260 ENOG4105RVB Prepilin peptidase dependent protein c GTH21_RS18265 ENOG4105SEN Protein of unknown function (DUF2509) GTH21_RS18270 ENOG4105JCS prepilin peptidase dependent protein GTH21_RS18275 ENOG4105IPU prepilin peptidase dependent protein A GTH21_RS18280 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GTH21_RS18285 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GTH21_RS18290 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GTH21_RS18295 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GTH21_RS18305 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GTH21_RS18310 ENOG4105EE5 Membrane protein terC GTH21_RS18315 ENOG4105SUV lipoprotein YgdR GTH21_RS18320 ENOG4105CPC Aldo Keto reductase GTH21_RS18325 ENOG4107S74 Lysophospholipid transporter LplT GTH21_RS18330 ENOG4105CEY Amp-dependent synthetase and ligase GTH21_RS18335 ENOG41060NJ transcriptional regulator GTH21_RS18345 ENOG4107YCY Transcriptional regulator GTH21_RS18350 ENOG4105CS2 ec 3.2.1.21 GTH21_RS18355 ENOG4105CK1 PTS System GTH21_RS18360 ENOG4105DDV Transcriptional regulator (LacI family GTH21_RS18370 ENOG4105RQF LysR family Transcriptional regulator GTH21_RS18380 ENOG4105YKW GTH21_RS18385 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GTH21_RS18390 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GTH21_RS18395 ENOG4108IJ9 (ABC) transporter GTH21_RS18410 ENOG4108HKT sucrose-6-phosphate hydrolase GTH21_RS18415 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GTH21_RS18425 ENOG4106NDP Transcriptional regulator GTH21_RS18430 ENOG4107QNK )-transporter GTH21_RS18435 ENOG4105CHR reductase GTH21_RS18445 ENOG4105CAZ oligogalacturonide lyase GTH21_RS18450 ENOG4108QGT oligogalacturonate-specific porin GTH21_RS18455 ENOG4105CHU acetyl-coa acetyltransferase GTH21_RS18460 ENOG4105C5Q Transcriptional regulator GTH21_RS18470 ENOG4108MHD transport protein GTH21_RS18475 ENOG4107S5I aldo keto reductase GTH21_RS18515 ENOG4108T1W Fimbrial subunit type 3 GTH21_RS18525 ENOG4108KTG Membrane protein, drug metabolite transporter GTH21_RS18530 ENOG4108ZT1 Transcriptional regulator GTH21_RS18535 ENOG4105D7X high-affinity nickel-transporter GTH21_RS18540 ENOG4108W9T type 1 fimbriae regulatory protein GTH21_RS18545 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off GTH21_RS18555 ENOG4108RQP Major type 1 subunit fimbrin GTH21_RS18560 ENOG4108S54 Fimbrial protein GTH21_RS18565 ENOG4108NAE Fimbrial chaperone protein GTH21_RS18570 ENOG4105CW0 outer membrane usher protein GTH21_RS18575 ENOG4108SQA Fimbrial GTH21_RS18580 ENOG4108T65 Fimbrial GTH21_RS18585 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin GTH21_RS18595 ENOG410830R acetyltransferase GTH21_RS18600 ENOG4105VR1 Pfam:DUF1271 GTH21_RS18610 ENOG4105J12 Multidrug resistance protein mdtN GTH21_RS18615 ENOG4108MI0 Resistance protein GTH21_RS18620 ENOG4105ETP RND efflux system, outer membrane lipoprotein GTH21_RS18625 ENOG4105V2F Uncharacterized protein yoac GTH21_RS18630 ENOG4105DUX Transporter GTH21_RS18635 ENOG4105K89 arsenate reductase GTH21_RS18640 ENOG4107R5R arsenical pump membrane protein GTH21_RS18660 ENOG4105W7K Transcriptional regulator GTH21_RS18675 ENOG4105CPC Aldo Keto reductase GTH21_RS18690 ENOG4105C0R drug resistance transporter emrb qaca subfamily GTH21_RS18765 ENOG4105XB7 anti-repressor protein GTH21_RS18785 ENOG4105DFP Integrase GTH21_RS18795 ENOG4108K5P (LipO)protein GTH21_RS18805 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GTH21_RS18810 ENOG4105CRK lysyL-tRNA synthetase GTH21_RS18820 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GTH21_RS18825 ENOG4105T95 Thiol disulfide interChange protein GTH21_RS18830 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GTH21_RS18835 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GTH21_RS18840 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB GTH21_RS18845 ENOG4105Y75 tpr repeat protein GTH21_RS18855 ENOG4108UT2 hemolysin iii GTH21_RS18860 ENOG4105N5Z UPF0267 protein GTH21_RS18865 ENOG4108Q3X Transcriptional regulator GTH21_RS18870 ENOG4105CS2 ec 3.2.1.21 GTH21_RS18890 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GTH21_RS18895 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GTH21_RS18900 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GTH21_RS18905 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GTH21_RS18910 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GTH21_RS18915 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GTH21_RS18920 ENOG4105D0A hydroxylase GTH21_RS18925 ENOG4107RAQ aminopeptidase GTH21_RS18930 ENOG4105E07 UPF0149 protein GTH21_RS18935 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GTH21_RS18945 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GTH21_RS18950 ENOG4108JQ1 Dehydrogenase GTH21_RS18960 ENOG4105E66 phosphoriboisomerase A GTH21_RS18965 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GTH21_RS18970 ENOG4105MPN Membrane GTH21_RS18975 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GTH21_RS18980 ENOG4105D64 Mechanosensitive ion channel GTH21_RS18985 ENOG4105D2N Aldolase GTH21_RS18995 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GTH21_RS19000 ENOG4105CV1 Transketolase (EC 2.2.1.1) GTH21_RS19005 ENOG4108K0D peptidase, M48 GTH21_RS19010 ENOG4105J5J Outer membrane porin GTH21_RS19025 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) GTH21_RS19030 ENOG4105CHR reductase GTH21_RS19050 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase GTH21_RS19060 ENOG4108FUF Transcriptional regulator, IclR family GTH21_RS19065 ENOG4105CHR reductase GTH21_RS19090 ENOG4105CYW agmatinase GTH21_RS19110 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GTH21_RS19115 ENOG4107QNK )-transporter GTH21_RS19120 ENOG4105GPY SprT protein GTH21_RS19125 ENOG4105RWS endonuclease I GTH21_RS19130 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GTH21_RS19135 ENOG4105D7Z glutathione synthase GTH21_RS19140 ENOG4108UJU UPF0301 protein GTH21_RS19145 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GTH21_RS19150 ENOG41086KC Transcriptional regulator GTH21_RS19160 ENOG4105CZX twitching motility protein GTH21_RS19170 ENOG4108VIA integral membrane protein GTH21_RS19175 ENOG4105VZ9 UPF0235 protein GTH21_RS19180 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GTH21_RS19185 ENOG4105CSA Coproporphyrinogen iii oxidase GTH21_RS19190 ENOG4105K33 Periplasmic Protein GTH21_RS19195 ENOG41090ED Protein with unknown function (DUF469) GTH21_RS19200 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GTH21_RS19205 ENOG4105CEN a g-specific adenine glycosylase GTH21_RS19210 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GTH21_RS19215 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GTH21_RS19220 ENOG4105EAA nucleoside GTH21_RS19225 ENOG4105CXN decarboxylase GTH21_RS19230 ENOG4108UQV Membrane GTH21_RS19265 ENOG4105MFG Antirestriction protein GTH21_RS19295 ENOG4105HVQ Regulatory factor of maltose metabolism GTH21_RS19300 ENOG4105VEQ Cold shock protein GTH21_RS19310 ENOG4105HVQ Regulatory factor of maltose metabolism GTH21_RS19550 ENOG4105CDU Replicative dna helicase GTH21_RS19590 ENOG4105C28 cystathionine GTH21_RS19595 ENOG4105CC0 LysR family Transcriptional regulator GTH21_RS19615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GTH21_RS19620 ENOG4106032 Glutathionylspermidine synthase GTH21_RS19635 ENOG4105CYM Glutathione S-transferase GTH21_RS19640 ENOG410900S Protein of unknown function (DUF2623) GTH21_RS19650 ENOG4108TEB UPF0114 protein GTH21_RS19655 ENOG4105E4I Glycoside hydrolase family 28 GTH21_RS19660 ENOG4105CT4 transporter GTH21_RS19665 ENOG4108ZZF transport protein (ExbD) GTH21_RS19670 ENOG4105CWK Biopolymer transport protein, ExbB GTH21_RS19675 ENOG4105C28 cystathionine GTH21_RS19680 ENOG4108K81 inner membrane protein YghB GTH21_RS19685 ENOG4105CF7 AraC family transcriptional regulator GTH21_RS19690 ENOG4108I6A alcohol dehydrogenase GTH21_RS19695 ENOG4105CV8 reductase GTH21_RS19705 ENOG4105CCT upf0313 protein GTH21_RS19710 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) GTH21_RS19715 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GTH21_RS19720 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GTH21_RS19725 ENOG4105F4I Transcriptional regulator GTH21_RS19730 ENOG4105H4F exported protein GTH21_RS19735 ENOG4105XJC Two component transcriptional regulator (Winged helix family GTH21_RS19740 ENOG4105DHQ Histidine kinase GTH21_RS19745 ENOG4105NF4 modulator of drug activity GTH21_RS19750 ENOG4105VRH Antibiotic biosynthesis monooxygenase GTH21_RS19755 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GTH21_RS19760 ENOG4105IPS esterase GTH21_RS19765 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GTH21_RS19770 ENOG4108SX3 cytoplasmic protein GTH21_RS19775 ENOG41087AY ADP-Ribose pyrophosphatase GTH21_RS19785 ENOG4105F1G UPF0441 protein GTH21_RS19790 ENOG4106032 Glutathionylspermidine synthase GTH21_RS19795 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GTH21_RS19805 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GTH21_RS19810 ENOG4105W0Z cytoplasmic protein GTH21_RS19825 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GTH21_RS19830 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GTH21_RS19835 ENOG4105I7R Adenylate cyclase GTH21_RS19840 ENOG4106MWK domain protein GTH21_RS19845 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GTH21_RS19850 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GTH21_RS19855 ENOG4107ZVW dihydroneopterin aldolase GTH21_RS19860 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GTH21_RS19875 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GTH21_RS19880 ENOG4108YZ9 Urea amidohydrolase subunit gamma GTH21_RS19885 ENOG4105KI2 Urea amidohydrolase subunit beta GTH21_RS19890 ENOG4105CQM Urea amidohydrolase subunit alpha GTH21_RS19895 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) GTH21_RS19905 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GTH21_RS19915 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GTH21_RS19925 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GTH21_RS19930 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GTH21_RS19935 ENOG4108VCA G U mismatch-specific DNA glycosylase GTH21_RS19965 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles GTH21_RS19975 ENOG4108YGG dna repair protein GTH21_RS19980 ENOG4105MFG Antirestriction protein GTH21_RS19985 ENOG4106H6R UPF0380 protein GTH21_RS19990 ENOG4105F4K antigen 43 GTH21_RS20020 ENOG4105D85 methylase GTH21_RS20025 ENOG4105F6A helicase GTH21_RS20030 ENOG4105ECI YeeC-like protein GTH21_RS20085 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GTH21_RS20150 ENOG4105JXR Protein of unknown function (DUF3296) GTH21_RS20155 ENOG410693A DNA-binding protein GTH21_RS20195 ENOG4108WQH regulatoR GTH21_RS20200 ENOG4105BZU Histidine kinase GTH21_RS20205 ENOG4108V08 YfdX protein GTH21_RS20210 ENOG4108YK4 Acid-resistance membrane protein GTH21_RS20215 ENOG4105XXV Acid-resistance protein GTH21_RS20220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GTH21_RS20225 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit GTH21_RS20230 ENOG4108ZFT Dehydratase small subunit GTH21_RS20235 ENOG4105YCI dehydratase medium subunit GTH21_RS20250 ENOG4105C0A alcohol dehydrogenase GTH21_RS20280 ENOG4105CMT Dihydroxyacetone kinase GTH21_RS20285 ENOG4108UTZ Dihydroxyacetone kinase GTH21_RS20300 ENOG4105Q26 Siderophore-interacting protein GTH21_RS20310 ENOG4105NTW Transcriptional regulator GTH21_RS20315 ENOG4105C8Y Acetylornithine aminotransferase GTH21_RS20320 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound GTH21_RS20325 ENOG41061GT Aldolase GTH21_RS20330 ENOG4105D4B ABC, transporter GTH21_RS20335 ENOG4105F5R ABC transporter GTH21_RS20340 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GTH21_RS20345 ENOG4105C2J ABC transporter GTH21_RS20350 ENOG4105DKT Transcriptional regulator GTH21_RS20355 ENOG4107RYS Autoinducer-2 (AI-2) kinase GTH21_RS20360 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GTH21_RS20365 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GTH21_RS20380 ENOG4108VKG metal-dependent hydrolase GTH21_RS20385 ENOG4105EE0 oxidoreductase GTH21_RS20390 ENOG4105DU1 integral membrane protein, terc GTH21_RS20395 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GTH21_RS20400 ENOG4105P66 Membrane GTH21_RS20405 ENOG4105CTX dehydratase GTH21_RS20415 ENOG4105DPW Major facilitator superfamily MFS_1 GTH21_RS20420 ENOG4107YCY Transcriptional regulator GTH21_RS20425 ENOG4106W5V Membrane GTH21_RS20430 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) GTH21_RS20435 ENOG4105WAY exported protein GTH21_RS20440 ENOG4105NE1 Conserved Protein GTH21_RS20445 ENOG41090KG Inner membrane protein YqjE GTH21_RS20450 ENOG4105YJD GTH21_RS20455 ENOG4108VBZ doxx family GTH21_RS20460 ENOG4105CHF Glutathione S-transferase GTH21_RS20465 ENOG4105KAF membrAne GTH21_RS20470 ENOG4105CWB LysR family transcriptional Regulator GTH21_RS20475 ENOG4108CNN domain protein GTH21_RS20480 ENOG4106D80 Uncharacterized protein YhaL GTH21_RS20505 ENOG4105BZW Glycerate kinase GTH21_RS20510 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GTH21_RS20515 ENOG4105CNV Aldolase GTH21_RS20520 ENOG4105DJB Major Facilitator Superfamily GTH21_RS20530 ENOG4105CTX dehydratase GTH21_RS20535 ENOG4107UEK pfkb domain protein GTH21_RS20540 ENOG4105E98 transcriptional regulator DeoR family GTH21_RS20550 ENOG4105D2N Aldolase GTH21_RS20555 ENOG4105DE4 1-phosphofructokinase GTH21_RS20560 ENOG4105DM4 PTS System GTH21_RS20565 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GTH21_RS20570 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GTH21_RS20575 ENOG41082GB PTS system galactitol-specific transporter subunit IIA GTH21_RS20580 ENOG41090UW PTS System GTH21_RS20585 ENOG4105DT3 PTS system, galactitol-specific IIc component GTH21_RS20590 ENOG4107WTH Galactitol-1-phosphate dehydrogenase GTH21_RS20600 ENOG4107R3N Filamentation induced by cAMP protein fic GTH21_RS20605 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GTH21_RS20610 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) GTH21_RS20615 ENOG41082RQ UPF0102 protein GTH21_RS20620 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GTH21_RS20625 ENOG4105W4M Transport-associated protein GTH21_RS20630 ENOG4107S21 permease GTH21_RS20635 ENOG4105K4T epimerase GTH21_RS20640 ENOG4107R7Y intracellular protease Pfpi family GTH21_RS20645 ENOG4108ZPB UPF0306 protein GTH21_RS20650 ENOG41082IR Excinuclease ABC C subunit domain protein GTH21_RS20655 ENOG4108YYD acetyltransferase GTH21_RS20675 ENOG4105DEN Luciferase family GTH21_RS20720 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GTH21_RS20740 ENOG4108K70 Transcriptional regulator GTH21_RS20745 ENOG4105CIC tryptophan-specific transport protein GTH21_RS20750 ENOG4105C1J atp-dependent rna helicase GTH21_RS20765 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GTH21_RS20770 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GTH21_RS20775 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GTH21_RS20780 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GTH21_RS20785 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GTH21_RS20790 ENOG4105CHV Transcription elongation factor NusA GTH21_RS20795 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GTH21_RS20810 ENOG4105CDH Citrulline--aspartate ligase GTH21_RS20815 ENOG4108PNB DNA-binding transcriptional regulator GTH21_RS20820 ENOG4108UII YfaZ family GTH21_RS20835 ENOG4105NTZ Preprotein translocase subunit SecG GTH21_RS20840 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GTH21_RS20845 ENOG4105EEI dihydropteroate synthase GTH21_RS20850 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GTH21_RS20855 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GTH21_RS20860 ENOG4105HBR Rna-binding protein GTH21_RS20865 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GTH21_RS20870 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GTH21_RS20875 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GTH21_RS20880 ENOG4105QYV Membrane GTH21_RS20885 ENOG4105K46 50S ribosomal protein l27 GTH21_RS20890 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GTH21_RS20895 ENOG4105EAH synthase GTH21_RS20900 ENOG4105HVQ Regulatory factor of maltose metabolism GTH21_RS20905 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GTH21_RS20910 ENOG4105VFK BolA family GTH21_RS20915 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GTH21_RS20920 ENOG4105E3I toluene tolerance GTH21_RS20925 ENOG4107PE3 Mammalian cell entry related domain protein GTH21_RS20930 ENOG4105CY3 ABC transporter, permease GTH21_RS20935 ENOG4105DHJ ABC, transporter GTH21_RS20940 ENOG4105FEU K -dependent Na -Ca exchanger GTH21_RS20945 ENOG4105C2X Arabinose 5-phosphate isomerase GTH21_RS20950 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GTH21_RS20955 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) GTH21_RS20960 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GTH21_RS20965 ENOG4108IUZ ABC transporter GTH21_RS20970 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GTH21_RS20975 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GTH21_RS20980 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GTH21_RS20985 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GTH21_RS20990 ENOG41080Z8 PHOSPHOCARRIER protein GTH21_RS21000 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GTH21_RS21005 ENOG4105BZU Histidine kinase GTH21_RS21010 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GTH21_RS21020 ENOG4105CPQ Dehydrogenase GTH21_RS21025 ENOG4108I5G Major Facilitator superfamily GTH21_RS21030 ENOG4105N5T Radical SAM Protein GTH21_RS21035 ENOG4105CBC glutamate synthase GTH21_RS21040 ENOG4105BZ8 glutamate synthase GTH21_RS21050 ENOG4105KB2 stringent starvation protein b GTH21_RS21055 ENOG4107MKT Stringent starvation protein a GTH21_RS21070 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GTH21_RS21075 ENOG4105D6Z AFG1 family ATPase GTH21_RS21080 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GTH21_RS21085 ENOG4105C0H protease GTH21_RS21090 ENOG4105C0H protease GTH21_RS21095 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GTH21_RS21100 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GTH21_RS21105 ENOG4105RID UPF0379 protein yhcN GTH21_RS21110 ENOG4105RID UPF0379 protein yhcN GTH21_RS21115 ENOG4105UNR (Barnase) inhibitor GTH21_RS21120 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) GTH21_RS21135 ENOG4105CR8 Transcriptional regulator GTH21_RS21140 ENOG4105D1U peptidase U62 modulator of DNA gyrase GTH21_RS21145 ENOG4105QD6 exported protein GTH21_RS21150 ENOG4105C03 ribonuclease GTH21_RS21155 ENOG4108Z03 MAF-like protein GTH21_RS21160 ENOG4105VQ7 Rod shape-determining protein MreD GTH21_RS21165 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GTH21_RS21175 ENOG41062P1 Diguanylate cyclase phosphodiesterase GTH21_RS21190 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) GTH21_RS21200 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GTH21_RS21205 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GTH21_RS21210 ENOG4105RG0 Membrane GTH21_RS21215 ENOG4108IA2 Sodium pantothenate symporter GTH21_RS21220 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GTH21_RS21225 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GTH21_RS21235 ENOG4108XG4 DNA-binding transcriptional regulator GTH21_RS21240 ENOG4105C1P efflux transporter, rnd family, mfp subunit GTH21_RS21245 ENOG4105BZS acriflavin resistance protein GTH21_RS21250 ENOG4105XCM membrane LIPOPROTEIN GTH21_RS21280 ENOG4108Z0R Transferase GTH21_RS21285 ENOG4105SG3 Protein of unknown function (DUF1488) GTH21_RS21290 ENOG4105E2X shikimate dehydrogenase GTH21_RS21295 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GTH21_RS21300 ENOG4108WI1 Dna topoisomerase GTH21_RS21310 ENOG4105C79 DNA protecting protein DprA GTH21_RS21315 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GTH21_RS21320 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GTH21_RS21325 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GTH21_RS21330 ENOG4105C1A potassium transporter peripheral membrane GTH21_RS21335 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GTH21_RS21340 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GTH21_RS21345 ENOG4105W1Y Transcriptional regulator GTH21_RS21350 ENOG4105VTS DnaJ-like, subfamily C GTH21_RS21355 ENOG4108ZT0 50S ribosomal protein l17 GTH21_RS21360 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GTH21_RS21365 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GTH21_RS21370 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GTH21_RS21375 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GTH21_RS21380 ENOG41067V7 50S ribosomal protein L36 GTH21_RS21385 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GTH21_RS21390 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GTH21_RS21395 ENOG4105VPB 50S ribosomal protein L30 GTH21_RS21400 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GTH21_RS21410 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GTH21_RS21415 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GTH21_RS21430 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GTH21_RS21435 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GTH21_RS21440 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GTH21_RS21445 ENOG41083MP 50s ribosomal protein l29 GTH21_RS21450 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GTH21_RS21455 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GTH21_RS21460 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GTH21_RS21465 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GTH21_RS21470 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GTH21_RS21480 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GTH21_RS21485 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GTH21_RS21500 ENOG4108UQY Iron-storage protein GTH21_RS21505 ENOG4105W53 bacterioferritin-associated ferredoxin GTH21_RS21510 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GTH21_RS21515 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GTH21_RS21520 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GTH21_RS21525 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GTH21_RS21530 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GTH21_RS21535 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GTH21_RS21540 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GTH21_RS21545 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GTH21_RS21550 ENOG4105WWK YheO domain protein GTH21_RS21555 ENOG4108V1T peptidylprolyl cis-trans isomerase GTH21_RS21560 ENOG4105VRX Protein slyX homolog GTH21_RS21565 ENOG4108YZY peptidylprolyl cis-trans isomerase GTH21_RS21570 ENOG4105VKU nucleicacid-binding protein GTH21_RS21575 ENOG4105CKD glutathione-regulated potassium-efflux system protein GTH21_RS21580 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GTH21_RS21585 ENOG4105C5H ABC transporter GTH21_RS21595 ENOG4105DNZ Alpha Beta Hydrolase GTH21_RS21605 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GTH21_RS21610 ENOG4108UKZ OsmC family GTH21_RS21615 ENOG4107RYR Transcriptional regulator, Crp Fnr family GTH21_RS21620 ENOG410613R integral membrane protein, YccS YhfK family GTH21_RS21625 ENOG4105C8Y Acetylornithine aminotransferase GTH21_RS21635 ENOG4105MZU cell filamentation protein GTH21_RS21640 ENOG4106195 uncharacterized protein yhfG GTH21_RS21645 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GTH21_RS21650 ENOG4106DTQ Protein TsgA homolog GTH21_RS21655 ENOG4105DZC cytosine deaminase GTH21_RS21665 ENOG4107QZF nitrite reductase NADPH large subunit GTH21_RS21670 ENOG4105WZK nitrite reductase NADPH small subunit GTH21_RS21675 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GTH21_RS21680 ENOG4105C31 Tryptophanyl-tRNA synthetase GTH21_RS21690 ENOG4105DJV ribulose-phosphate 3-epimerase GTH21_RS21695 ENOG4105DFE Dna adenine methylase GTH21_RS21700 ENOG4105EGB membrane protein DamX GTH21_RS21705 ENOG4105D49 3-dehydroquinate synthase GTH21_RS21710 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GTH21_RS21715 ENOG4105E4G Type IV pilus GTH21_RS21740 ENOG4108JQC penicillin-binding protein 1A GTH21_RS21745 ENOG4107RK2 ADP-ribose diphosphatase NudE GTH21_RS21750 ENOG4105DQY intracellular growth attenuator GTH21_RS21755 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 GTH21_RS21760 ENOG4105VEJ Heat shock protein GTH21_RS21775 ENOG4105E0F Histidine kinase GTH21_RS21785 ENOG4108RRZ Transcription elongation factor GreB GTH21_RS21790 ENOG4105BZM domain protein GTH21_RS21795 ENOG4105XFK Ferrous iron transport protein A GTH21_RS21800 ENOG4105CE1 Ferrous iron transport protein b GTH21_RS21805 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) GTH21_RS21815 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GTH21_RS21820 ENOG4105MJ2 Competence protein GTH21_RS21825 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) GTH21_RS21830 ENOG4105C6Z Gluconate GTH21_RS21835 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GTH21_RS21840 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GTH21_RS21845 ENOG41061ZR Transcriptional regulator GTH21_RS21850 ENOG4105E98 transcriptional regulator DeoR family GTH21_RS21855 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GTH21_RS21860 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GTH21_RS21865 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GTH21_RS21880 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GTH21_RS21885 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GTH21_RS21890 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GTH21_RS21895 ENOG4108IUM Glycogen debranching enzyme GTH21_RS21900 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GTH21_RS21905 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GTH21_RS21915 ENOG4105C6Z Gluconate GTH21_RS21920 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GTH21_RS21925 ENOG4105DIQ Transcriptional regulator GTH21_RS21930 ENOG4105C2I pirin domain protein GTH21_RS21935 ENOG4105D9R oxidoreductase GTH21_RS21945 ENOG4105WCN acetyltransferase GTH21_RS21950 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GTH21_RS21955 ENOG4105WC8 Conserved Protein GTH21_RS21960 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GTH21_RS21975 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GTH21_RS21980 ENOG4105BZ7 extracellular solute-binding protein family 1 GTH21_RS21990 ENOG41060M8 Pfam:PhdYeFM GTH21_RS21995 ENOG4108IV0 ABC, transporter GTH21_RS22000 ENOG4105C0Z ABC transporter GTH21_RS22005 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GTH21_RS22010 ENOG4105C32 Amino acid ABC transporter (Permease) GTH21_RS22015 ENOG4105CP9 extracellular ligand-binding receptor GTH21_RS22020 ENOG4105U59 -acetyltransferase GTH21_RS22025 ENOG4105CP9 extracellular ligand-binding receptor GTH21_RS22035 ENOG4108JPW Aminotransferase GTH21_RS22050 ENOG4105CRP Part of the ABC transporter FtsEX involved in GTH21_RS22055 ENOG4105CAK Cell division ATP-binding protein ftsE GTH21_RS22060 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GTH21_RS22065 ENOG4106H78 methyltransferase GTH21_RS22070 ENOG4105MG3 Membrane GTH21_RS22080 ENOG4107FS9 Membrane GTH21_RS22090 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GTH21_RS22095 ENOG4105EX9 Membrane GTH21_RS22100 ENOG4108W1V Lipoprotein GTH21_RS22105 ENOG4105F9N Major Facilitator Superfamily GTH21_RS22110 ENOG4105DSF transport protein GTH21_RS22115 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GTH21_RS22120 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GTH21_RS22125 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GTH21_RS22130 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GTH21_RS22135 ENOG4105C3I Nad-dependent epimerase dehydratase GTH21_RS22140 ENOG4105CKK Glycosyl transferase, family 2 GTH21_RS22145 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GTH21_RS22150 ENOG4105PY6 Phenolic acid decarboxylase GTH21_RS22160 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GTH21_RS22165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GTH21_RS22170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GTH21_RS22180 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS22190 ENOG4105CJW magnesium transporter GTH21_RS22195 ENOG4105CBX hi0933 family GTH21_RS22200 ENOG4105CJ3 phosphate transporter GTH21_RS22205 ENOG4108V6B universal stress protein B GTH21_RS22215 ENOG4105DUX Transporter GTH21_RS22220 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GTH21_RS22225 ENOG4105DGW oligopeptidase A GTH21_RS22230 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GTH21_RS22235 ENOG4105D6S protein involved in catabolism of external DNA GTH21_RS22240 ENOG4105DC8 reductase GTH21_RS22250 ENOG4105C0A alcohol dehydrogenase GTH21_RS22265 ENOG4105CHR reductase GTH21_RS22270 ENOG4105CBN LysR family transcriptional regulator GTH21_RS22275 ENOG4107H3J ribonuclease GTH21_RS22280 ENOG4105CSH Transporter GTH21_RS22285 ENOG41066T0 asmA family GTH21_RS22300 ENOG4105CS0 peptidase GTH21_RS22305 ENOG4105CK2 sodium dicarboxylate symporter GTH21_RS22310 ENOG4105BZU Histidine kinase GTH21_RS22315 ENOG4105EJG cellulose synthase GTH21_RS22320 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GTH21_RS22325 ENOG4107EEX Cellulose synthase regulator protein GTH21_RS22330 ENOG4107QZ7 Cellulose synthase catalytic subunit GTH21_RS22335 ENOG4105UTS cellulose synthase operon protein YhjQ GTH21_RS22340 ENOG410661M cytoplasmic protein GTH21_RS22345 ENOG4105U74 cellulose biosynthesis protein BcsE GTH21_RS22350 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT GTH21_RS22355 ENOG4105D1V cellulose synthase operon protein YhjU GTH21_RS22370 ENOG4105EJG cellulose synthase GTH21_RS22375 ENOG4107EEX Cellulose synthase regulator protein GTH21_RS22380 ENOG4107QZ7 Cellulose synthase catalytic subunit GTH21_RS22385 ENOG4107U53 septum site-determining protein minD GTH21_RS22400 ENOG4108JQ7 (ABC) transporter GTH21_RS22405 ENOG4105C3U ABC transporter GTH21_RS22410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GTH21_RS22415 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GTH21_RS22420 ENOG4105DEF Extracellular solute-binding protein, family 5 GTH21_RS22450 ENOG4105DIJ Phosphoethanolamine transferase GTH21_RS22455 ENOG4105FCD Major Facilitator GTH21_RS22460 ENOG4105EAX Putative lipase GTH21_RS22465 ENOG4108R3E Dna-3-methyladenine glycosylase i GTH21_RS22470 ENOG4105HNP -acetyltransferase GTH21_RS22475 ENOG4107QY8 reductase GTH21_RS22480 ENOG4108ZG0 Ompa motb domain protein GTH21_RS22490 ENOG4108M60 Transcriptional regulator GTH21_RS22500 ENOG4105D7K pfkb domain protein GTH21_RS22510 ENOG4105C5I Dehydrogenase GTH21_RS22515 ENOG4106JH6 (LipO)protein GTH21_RS22520 ENOG4105D2S major facilitator superfamily GTH21_RS22525 ENOG4105MVF Transcriptional regulator GTH21_RS22540 ENOG41060TC Hok gef cell toxic protein GTH21_RS22550 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GTH21_RS22555 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GTH21_RS22565 ENOG4105MEV Acyl-transferase GTH21_RS22570 ENOG4108Z12 YiaAB two helix domain-containing protein GTH21_RS22575 ENOG410688U Inner membrane protein yiaB GTH21_RS22580 ENOG4105CMG Carbohydrate kinase GTH21_RS22585 ENOG4105C93 Xylose Isomerase GTH21_RS22590 ENOG4105DFW ABC transporter GTH21_RS22600 ENOG4108HWW ABC transporter GTH21_RS22605 ENOG4105T16 Transcriptional regulator (AraC family) GTH21_RS22610 ENOG4108UR8 BAX protein GTH21_RS22615 ENOG4107T9C Alpha amylase catalytic region GTH21_RS22620 ENOG4105JKW Valine--pyruvate aminotransferase GTH21_RS22625 ENOG4108RC0 Electron transport protein GTH21_RS22630 ENOG4105J4Q Transcriptional regulator GTH21_RS22635 ENOG4105EM7 Selenocysteine-specific translation elongation factor GTH21_RS22640 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GTH21_RS22645 ENOG4108U78 Glutathione S-transferase GTH21_RS22655 ENOG4105CTS PTS system mannitol-specific GTH21_RS22660 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GTH21_RS22665 ENOG4105E61 Mannitol repressor protein GTH21_RS22675 ENOG4108YYI Protein of unknown function (DUF2810) GTH21_RS22680 ENOG4105DAA L-lactate GTH21_RS22685 ENOG41073TP transcriptional regulator GTH21_RS22690 ENOG4105DMF Dehydrogenase GTH21_RS22695 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GTH21_RS22705 ENOG4105D7W serine acetyltransferase GTH21_RS22710 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GTH21_RS22715 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GTH21_RS22720 ENOG4105VW4 glutaredoxin 3 GTH21_RS22725 ENOG4107YZP Rhodanese domain protein GTH21_RS22735 ENOG41063SB peptidase GTH21_RS22740 ENOG4105PXI polysaccharide deacetylase GTH21_RS22745 ENOG4106WTF Glycosyl transferase, family 2 GTH21_RS22750 ENOG4105CPQ Dehydrogenase GTH21_RS22755 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GTH21_RS22760 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GTH21_RS22765 ENOG4105XA0 heptosyltransferase ii GTH21_RS22770 ENOG4105D16 lipopolysaccharide heptosyltransferase i GTH21_RS22775 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GTH21_RS22780 ENOG41068PG O-Antigen polymerase GTH21_RS22795 ENOG4105DKP glycosyl transferase, family 9 GTH21_RS22805 ENOG4105CPK Glycosyl transferase (Group 1 GTH21_RS22810 ENOG4105K64 Glycosyl transferase, family 2 GTH21_RS22815 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GTH21_RS22820 ENOG4106WTF Glycosyl transferase, family 2 GTH21_RS22825 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GTH21_RS22830 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GTH21_RS22835 ENOG4105W0E 50S ribosomal protein L33 GTH21_RS22840 ENOG4105KDC 50s ribosomal protein l28 GTH21_RS22845 ENOG4105W5Q DNA repair protein (RadC GTH21_RS22850 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GTH21_RS22855 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GTH21_RS22860 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GTH21_RS22870 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GTH21_RS22875 ENOG4107QWP ABC-2 type transporter GTH21_RS22880 ENOG4105CJ1 ABC, transporter GTH21_RS22905 ENOG4105DSJ YicC domain protein GTH21_RS22915 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) GTH21_RS22920 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GTH21_RS22930 ENOG4105EN6 Membrane GTH21_RS22935 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) GTH21_RS22940 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GTH21_RS22950 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GTH21_RS22955 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GTH21_RS22960 ENOG4105CB5 ATP-dependent DNA helicase recG GTH21_RS22965 ENOG4105CBT Fructose-1,6-bisphosphatase GTH21_RS22970 ENOG4105DP0 ferredoxin-NADP reductase GTH21_RS22975 ENOG4108VTS Membrane GTH21_RS22980 ENOG4105EBK exported protein GTH21_RS22985 ENOG4105CP7 Triose-phosphate isomerase GTH21_RS23000 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GTH21_RS23005 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GTH21_RS23010 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GTH21_RS23015 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GTH21_RS23020 ENOG4105D6U Sodium Glutamate Symporter GTH21_RS23025 ENOG4105C2W permease GTH21_RS23030 ENOG4105JV1 AsmA family GTH21_RS23035 ENOG4105CI1 PTS System GTH21_RS23040 ENOG4105F8D glycoside hydrolase family 4 GTH21_RS23050 ENOG4105CJQ hydrolase, family 31 GTH21_RS23055 ENOG4105CT4 transporter GTH21_RS23095 ENOG4105NI3 Protein of unknown function (DUF3237) GTH21_RS23115 ENOG4105DQ4 alcohol dehydrogenase GTH21_RS23125 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GTH21_RS23140 ENOG4105D01 (LipO)protein GTH21_RS23165 ENOG4105CR8 Transcriptional regulator GTH21_RS23175 ENOG410630P Transcriptional regulator GTH21_RS23195 ENOG4105C1P efflux transporter, rnd family, mfp subunit GTH21_RS23200 ENOG4105BZS acriflavin resistance protein GTH21_RS23205 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GTH21_RS23210 ENOG4105C2C drug resistance transporter, Bcr CflA GTH21_RS23215 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GTH21_RS23220 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) GTH21_RS23225 ENOG4108UZ3 Transporter GTH21_RS23230 ENOG4105T8A Uncharacterized protein YicS GTH21_RS23245 ENOG4105JSC dimethylmenaquinone methyltransferase GTH21_RS23255 ENOG4107F9Y LysR family transcriptional regulator GTH21_RS23265 ENOG4105D2S major facilitator superfamily GTH21_RS23270 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS23280 ENOG4105CK1 PTS System GTH21_RS23285 ENOG4105VCP PTS System GTH21_RS23290 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GTH21_RS23300 ENOG4108MP3 ABC transporter, permease GTH21_RS23315 ENOG4106S9K Transcriptional regulator GTH21_RS23320 ENOG4107STF Involved in phosphonate degradation (By similarity) GTH21_RS23325 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GTH21_RS23345 ENOG4108SAJ Protein of unknown function (DUF1198) GTH21_RS23350 ENOG4105CXY transporter GTH21_RS23355 ENOG4105CXY transporter GTH21_RS23360 ENOG4105BZU Histidine kinase GTH21_RS23365 ENOG4108KX4 response regulator GTH21_RS23370 ENOG4105M71 acetolactate synthase 1 regulatory subunit GTH21_RS23375 ENOG4105C7K acetolactate synthase GTH21_RS23405 ENOG4105E5M Multidrug resistance protein D GTH21_RS23410 ENOG4105W8I Transcriptional regulator GTH21_RS23435 ENOG4105JP4 Inner membrane protein yidG GTH21_RS23440 ENOG4105VG5 Membrane GTH21_RS23445 ENOG4105F8D glycoside hydrolase family 4 GTH21_RS23450 ENOG4105CI1 PTS System GTH21_RS23455 ENOG4105FDP GntR family transcriptional regulator GTH21_RS23460 ENOG4105D0C transport protein GTH21_RS23480 ENOG4105R2A (LipO)protein GTH21_RS23485 ENOG4105D99 atp gtp-binding protein GTH21_RS23490 ENOG4105DJB Major Facilitator Superfamily GTH21_RS23495 ENOG4105CXK mandelate racemase muconate lactonizing GTH21_RS23500 ENOG4108RTU Aldolase GTH21_RS23505 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GTH21_RS23510 ENOG4105EMF GntR family transcriptional regulator GTH21_RS23525 ENOG410667J hydrolase GTH21_RS23530 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GTH21_RS23535 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GTH21_RS23540 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GTH21_RS23550 ENOG4105VG0 50S ribosomal protein l34 GTH21_RS23560 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GTH21_RS23565 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GTH21_RS23570 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GTH21_RS23580 ENOG4105C2C drug resistance transporter, Bcr CflA GTH21_RS23590 ENOG4105E8Q phosphopantetheinyl transferase GTH21_RS23595 ENOG4108YYH Nadph-dependent fmn reductase GTH21_RS23600 ENOG4105C7N Xanthine uracil vitamin C permease GTH21_RS23610 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GTH21_RS23615 ENOG4107VKM 6-phosphogluconolactonase GTH21_RS23620 ENOG4105DYC esterase GTH21_RS23640 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS23645 ENOG4105E2Z phosphate ABC transporter (Permease GTH21_RS23650 ENOG4105C8U phosphate abc transporter GTH21_RS23655 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GTH21_RS23660 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GTH21_RS23665 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GTH21_RS23685 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GTH21_RS23690 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GTH21_RS23695 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GTH21_RS23700 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GTH21_RS23705 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GTH21_RS23725 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation GTH21_RS23730 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GTH21_RS23735 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GTH21_RS23740 ENOG4105QTB Flavodoxin GTH21_RS23745 ENOG4108VVK transcriptional Regulator, AsnC GTH21_RS23750 ENOG4105CU9 asparagine synthetase A GTH21_RS23765 ENOG4105DFH Transport of potassium into the cell (By similarity) GTH21_RS23775 ENOG4105C2J ABC transporter GTH21_RS23780 ENOG4105CNN ABC, transporter GTH21_RS23785 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GTH21_RS23790 ENOG4108RVA ribokinase GTH21_RS23795 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS23800 ENOG4105C0R drug resistance transporter emrb qaca subfamily GTH21_RS23805 ENOG4107EJG GntR family transcriptional regulator GTH21_RS23830 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GTH21_RS23835 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GTH21_RS23840 ENOG4105PC1 Conserved Protein GTH21_RS23845 ENOG4105E27 serine threonine protein kinase GTH21_RS23850 ENOG4108Z33 Thiol disulfide Interchange Protein GTH21_RS23855 ENOG4106HNH Acyl-transferase GTH21_RS23860 ENOG4105C2M dna polymerase I GTH21_RS23865 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GTH21_RS23870 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GTH21_RS23875 ENOG4105D4P Coproporphyrinogen iii oxidase GTH21_RS23880 ENOG4106FIY GTH21_RS23885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GTH21_RS23890 ENOG4105CUX Signal transduction histidine kinase GTH21_RS23895 ENOG4105C5F glutamine synthetase GTH21_RS23900 ENOG4105CI3 gtp-binding protein typa GTH21_RS23905 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GTH21_RS23910 ENOG4107S2Z UPF0761 membrane protein GTH21_RS23915 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GTH21_RS23920 ENOG4105SUU thioesterase domain GTH21_RS23930 ENOG41068KX affects formate dehydrogenase-N GTH21_RS23940 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) GTH21_RS23945 ENOG4108MG3 formate dehydrogenase GTH21_RS23950 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GTH21_RS23960 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GTH21_RS23970 ENOG4105CTQ phosphohexokinase GTH21_RS23985 ENOG4105D2N Aldolase GTH21_RS24030 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GTH21_RS24040 ENOG4105C0A alcohol dehydrogenase GTH21_RS24045 ENOG4105CNN ABC, transporter GTH21_RS24050 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GTH21_RS24055 ENOG4105C2J ABC transporter GTH21_RS24060 ENOG4105D4B ABC, transporter GTH21_RS24065 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) GTH21_RS24070 ENOG4105DKG l-rhamnose isomerase GTH21_RS24075 ENOG4105DET Rhamnulokinase GTH21_RS24080 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GTH21_RS24085 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) GTH21_RS24090 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) GTH21_RS24095 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GTH21_RS24100 ENOG4108RPX mosc domain containing protein GTH21_RS24105 ENOG4105E0F Histidine kinase GTH21_RS24110 ENOG4105E3W Two component transcriptional regulator (Winged helix family GTH21_RS24115 ENOG4105FMW periplasmic GTH21_RS24120 ENOG41076HS cation diffusion facilitator family transporter GTH21_RS24125 ENOG4105CTQ phosphohexokinase GTH21_RS24130 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GTH21_RS24135 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GTH21_RS24145 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GTH21_RS24150 ENOG41063M6 Cell Division Protein GTH21_RS24155 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS24160 ENOG4105C25 Primosomal protein n' GTH21_RS24165 ENOG4105VFB Binds the 23S rRNA (By similarity) GTH21_RS24170 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GTH21_RS24175 ENOG4105C28 cystathionine GTH21_RS24180 ENOG4105CFH Aspartokinase GTH21_RS24190 ENOG4105CGH 5'-nucleotidase GTH21_RS24195 ENOG4108Z8I decarboxylase GTH21_RS24200 ENOG4105CN8 Transcriptional regulator GTH21_RS24205 ENOG4105SYT Methylenetetrahydrofolate reductase GTH21_RS24210 ENOG4108Q5Y Membrane GTH21_RS24215 ENOG4105DCT glycerol dehydrogenase GTH21_RS24220 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GTH21_RS24225 ENOG4106R3P AraC family transcriptional regulator GTH21_RS24230 ENOG4108MEK Metal-binding protein YodA GTH21_RS24245 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GTH21_RS24250 ENOG4105CAS nag kinase GTH21_RS24255 ENOG4105CH7 arginosuccinase GTH21_RS24260 ENOG4105C5Q Transcriptional regulator GTH21_RS24265 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GTH21_RS24270 ENOG4105EJ2 Transcriptional regulator GTH21_RS24275 ENOG4108Y73 Membrane GTH21_RS24280 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) GTH21_RS24335 ENOG4108WFC UPF0438 protein yifE GTH21_RS24340 ENOG4105C0P Mg chelatase subunit ChlI GTH21_RS24355 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GTH21_RS24360 ENOG4105CM2 brancheD-chain amino acid aminotransferase GTH21_RS24365 ENOG4105C01 Dihydroxy-acid dehydratase GTH21_RS24370 ENOG4105C7B Threonine dehydratase GTH21_RS24375 ENOG4105EMY transcriptional regulator GTH21_RS24380 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GTH21_RS24385 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GTH21_RS24390 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GTH21_RS24395 ENOG4105C4R Atp-dependent dna helicase GTH21_RS24400 ENOG4108UQV Membrane GTH21_RS24415 ENOG4105C9X ppx gppa phosphatase GTH21_RS24420 ENOG4105C1J atp-dependent rna helicase GTH21_RS24430 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GTH21_RS24435 ENOG4105ESV Glycosyl transferase, family 4 GTH21_RS24440 ENOG4105SFE lipopolysaccharide biosynthesis protein GTH21_RS24445 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GTH21_RS24450 ENOG4107QQG Dehydrogenase GTH21_RS24455 ENOG4105C1B dTDP-glucose 4-6-dehydratase GTH21_RS24460 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GTH21_RS24465 ENOG4108WJ1 acetyltransferase GTH21_RS24470 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GTH21_RS24475 ENOG4105EGZ biosynthesis protein GTH21_RS24480 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) GTH21_RS24485 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) GTH21_RS24490 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family GTH21_RS24495 ENOG4105C85 amino acid GTH21_RS24525 ENOG410601J HemY protein GTH21_RS24530 ENOG4105ECF c-methyltransferase GTH21_RS24535 ENOG41076E6 Uroporphyrinogen-III Synthase GTH21_RS24540 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GTH21_RS24545 ENOG4107T0K Adenylate cyclase GTH21_RS24550 ENOG4105XQ6 frataxin-like protein GTH21_RS24555 ENOG4105S7Z (LipO)protein GTH21_RS24565 ENOG4105CT0 Protein of unknown function, DUF484 GTH21_RS24570 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GTH21_RS24575 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GTH21_RS24580 ENOG4105C4R Atp-dependent dna helicase GTH21_RS24585 ENOG4107QUT magnesium and cobalt transport protein CorA GTH21_RS24590 ENOG4105FR1 rard protein GTH21_RS24595 ENOG4108VUY thioesterase Superfamily protein GTH21_RS24600 ENOG4105HDD phospholipase GTH21_RS24605 ENOG4105C9U ATP-dependent DNA helicase RecQ GTH21_RS24610 ENOG4105CCF Lysine exporter protein (Lyse ygga) GTH21_RS24620 ENOG410829K Lysine exporter protein (Lyse ygga) GTH21_RS24625 ENOG4108EUD Lysophospholipase GTH21_RS24630 ENOG4105DQF Hydrolase GTH21_RS24635 ENOG4105EMK carboxylate amino acid amine transporter GTH21_RS24640 ENOG4105DZ2 Transcriptional regulator GTH21_RS24645 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GTH21_RS24650 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GTH21_RS24655 ENOG4107SXA Phosphorylase GTH21_RS24660 ENOG4105CGY Dna recombination protein GTH21_RS24665 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GTH21_RS24670 ENOG4105JC1 sterol-binding domain protein GTH21_RS24675 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GTH21_RS24680 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GTH21_RS24685 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GTH21_RS24690 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GTH21_RS24700 ENOG4105MDZ Transcriptional activator rfaH GTH21_RS24710 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GTH21_RS24715 ENOG4107QK7 reductase GTH21_RS24720 ENOG4105CHU acetyl-coa acetyltransferase GTH21_RS24725 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) GTH21_RS24730 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) GTH21_RS24735 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GTH21_RS24740 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GTH21_RS24745 ENOG4108RR8 protoporphyrinogen oxidase GTH21_RS24775 ENOG4105D4A Cell wall formation (By similarity) GTH21_RS24780 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GTH21_RS24785 ENOG4105CS9 pantothenic acid kinase GTH21_RS24810 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GTH21_RS24815 ENOG4105PM1 preprotein translocase subunit SecE GTH21_RS24820 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GTH21_RS24825 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GTH21_RS24830 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GTH21_RS24835 ENOG4108VZM 50s ribosomal protein L10 GTH21_RS24840 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GTH21_RS24845 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GTH21_RS24850 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GTH21_RS24855 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GTH21_RS24860 ENOG4105VCP PTS System GTH21_RS24870 ENOG4106TD9 Diguanylate cyclase GTH21_RS24875 ENOG4105D41 biosynthesis protein thiH GTH21_RS24880 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GTH21_RS24885 ENOG4105WHD thiamine biosynthesis protein ThiS GTH21_RS24890 ENOG4105D06 uba thif-type nad fad binding protein GTH21_RS24895 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GTH21_RS24900 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GTH21_RS24905 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) GTH21_RS24910 ENOG4105E09 nadh pyrophosphatase GTH21_RS24915 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GTH21_RS24920 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GTH21_RS24925 ENOG4105R2J Conserved Protein GTH21_RS24930 ENOG4105K70 DNA-binding protein GTH21_RS24935 ENOG4108T8B Protein of unknown function (DUF1481) GTH21_RS24940 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism GTH21_RS24945 ENOG4105BZU Histidine kinase GTH21_RS24955 ENOG4105C12 Phosphoribosylglycinamide synthetase GTH21_RS24960 ENOG4105DC1 bifunctional purine biosynthesis protein purh GTH21_RS24985 ENOG4105K5X acetyltransferase GTH21_RS24990 ENOG4105CVG Homoserine O-transsuccinylase GTH21_RS24995 ENOG4107QP3 malate synthase g GTH21_RS25000 ENOG4108I9X Isocitrate lyase GTH21_RS25005 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) GTH21_RS25010 ENOG41069M3 Transcriptional regulator GTH21_RS25015 ENOG4105C3R Methionine synthase GTH21_RS25020 ENOG4105EAM Na Pi-cotransporter GTH21_RS25030 ENOG4105FE9 pseudouridine synthase GTH21_RS25035 ENOG4108ZR5 Conserved Protein GTH21_RS25040 ENOG4105C09 Bile acid GTH21_RS25045 ENOG4105CFH Aspartokinase GTH21_RS25050 ENOG4107QP8 phosphohexose isomerase GTH21_RS25055 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GTH21_RS25065 ENOG4105KME endoribonuclease L-psp GTH21_RS25080 ENOG4105CEM UPF0597 protein GTH21_RS25085 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GTH21_RS25090 ENOG4105EG2 ABC transporter, permease GTH21_RS25095 ENOG4105D56 permease protein GTH21_RS25100 ENOG4107FKK extracellular solute-binding protein family 1 GTH21_RS25105 ENOG4108IJ9 (ABC) transporter GTH21_RS25110 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GTH21_RS25115 ENOG4107W52 maltose operon periplasmic protein GTH21_RS25120 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GTH21_RS25125 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GTH21_RS25130 ENOG4105E55 glycerol-3-phosphate acyltransferase GTH21_RS25135 ENOG41080IJ Diacylglycerol kinase GTH21_RS25140 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GTH21_RS25145 ENOG4107R73 Mate efflux family protein GTH21_RS25155 ENOG4105VDW Csbd family GTH21_RS25160 ENOG4105MYN Zinc uptake regulation protein GTH21_RS25170 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GTH21_RS25175 ENOG4105P4Z Phage shock protein G GTH21_RS25180 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GTH21_RS25185 ENOG4105CDU Replicative dna helicase GTH21_RS25190 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GTH21_RS25195 ENOG4105CGF Aromatic amino acid aminotransferase GTH21_RS25205 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GTH21_RS25210 ENOG4105MSB protein, conserved in bacteria GTH21_RS25215 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GTH21_RS25220 ENOG4108UUM single-stranded DNA-binding protein GTH21_RS25225 ENOG4105E4C Lytic transglycosylase catalytic GTH21_RS25235 ENOG4107RNH Outer membrane receptor FepA GTH21_RS25240 ENOG4108DMH HTH_ARAC GTH21_RS25260 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GTH21_RS25270 ENOG4105ECY inositol monophosphatase GTH21_RS25275 ENOG4105ETE Transcriptional regulator (LacI family GTH21_RS25280 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GTH21_RS25305 ENOG4105PMV Membrane GTH21_RS25310 ENOG4108M8H domain protein GTH21_RS25315 ENOG4108W3Q Transcriptional regulator GTH21_RS25320 ENOG4108Z4X TRANSCRIPTIONal GTH21_RS25325 ENOG4108K3A Glutathione S-transferase GTH21_RS25330 ENOG4105C7N Xanthine uracil vitamin C permease GTH21_RS25335 ENOG4105EEQ Na H antiporter GTH21_RS25340 ENOG4105CMU LysR family (Transcriptional regulator GTH21_RS25350 ENOG41067MG lrgb family GTH21_RS25360 ENOG4105MX3 Fimbrial GTH21_RS25365 ENOG4108VCD Chaperone GTH21_RS25370 ENOG4105CW0 outer membrane usher protein GTH21_RS25385 ENOG4107QN1 sodium solute GTH21_RS25390 ENOG41062QD Membrane GTH21_RS25395 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GTH21_RS25405 ENOG4105CK2 sodium dicarboxylate symporter GTH21_RS25410 ENOG41082ND Uncharacterized protein yjcO GTH21_RS25440 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GTH21_RS25445 ENOG4105CNN ABC, transporter GTH21_RS25450 ENOG4105C2J ABC transporter GTH21_RS25455 ENOG4105BZU Histidine kinase GTH21_RS25465 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein GTH21_RS25470 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) GTH21_RS25475 ENOG4105FD8 phosphonate metabolism protein PhnM GTH21_RS25480 ENOG4105HRV phosphonate c-p lyase system protein phnl GTH21_RS25485 ENOG4105ENV phosphonate C-P lyase system protein PhnK GTH21_RS25490 ENOG4105FT8 Phosphonate metabolism GTH21_RS25495 ENOG4105EKV Phosphonate metabolism protein GTH21_RS25500 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH GTH21_RS25505 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG GTH21_RS25510 ENOG4107RJJ Transcriptional regulator GTH21_RS25515 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase GTH21_RS25520 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GTH21_RS25525 ENOG4105CSH Transporter GTH21_RS25530 ENOG4108K2B transcriptional regulator GTH21_RS25535 ENOG4105F8D glycoside hydrolase family 4 GTH21_RS25540 ENOG4105CT4 transporter GTH21_RS25570 ENOG4105DVC DnaJ domain protein GTH21_RS25580 ENOG4108ZCF integral membrane protein GTH21_RS25600 ENOG4105CND Glycosyl transferase, family 2 GTH21_RS25605 ENOG4107BJW polysaccharide deacetylase GTH21_RS25610 ENOG4108TUY outer membrane protein PgaA GTH21_RS25660 ENOG4108SIC Transcriptional regulator GTH21_RS25665 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GTH21_RS25675 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GTH21_RS25680 ENOG4108IJ0 Aspartate ammonia-lyase GTH21_RS25685 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GTH21_RS25690 ENOG4105DVH amino acid GTH21_RS25700 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GTH21_RS25710 ENOG4105MX3 Fimbrial GTH21_RS25715 ENOG4105CW0 outer membrane usher protein GTH21_RS25720 ENOG4108VCD Chaperone GTH21_RS25730 ENOG4108ZVF (LipO)protein GTH21_RS25740 ENOG4108JJA ABC, transporter GTH21_RS25745 ENOG4108MBX Secretion Protein GTH21_RS25750 ENOG4105CJZ response regulator GTH21_RS25755 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GTH21_RS25760 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GTH21_RS25770 ENOG4106BSU Entericidin B GTH21_RS25775 ENOG4105KPY Small multidrug resistance protein GTH21_RS25785 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GTH21_RS25795 ENOG4105E33 succinate dehydrogenase GTH21_RS25800 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GTH21_RS25805 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GTH21_RS25810 ENOG4107SC7 Inner membrane transporter yjeM GTH21_RS25815 ENOG4105EGS Mechanosensitive ion channel GTH21_RS25820 ENOG4105DJ4 phosphatidylserine decarboxylase GTH21_RS25825 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GTH21_RS25830 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GTH21_RS25835 ENOG4106TNF Periplasmic binding protein GTH21_RS25855 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GTH21_RS25860 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GTH21_RS25865 ENOG4105K8N protein family UPF0079, ATPase GTH21_RS25870 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GTH21_RS25880 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GTH21_RS25885 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GTH21_RS25895 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GTH21_RS25900 ENOG4107QJR hflk protein GTH21_RS25905 ENOG4105EPW hflc protein GTH21_RS25920 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GTH21_RS25925 ENOG4105KPV Transcriptional regulator GTH21_RS25930 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GTH21_RS25935 ENOG4105C2N RNA methyltransferase TrmH family group 3 GTH21_RS25940 ENOG4105CSU acyl-Coa dehydrogenase GTH21_RS25945 ENOG4105S17 UPF0379 protein yjfN GTH21_RS25950 ENOG4105WSB biofilm stress and motility protein A GTH21_RS25955 ENOG4108MXZ Esterase GTH21_RS25970 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GTH21_RS25980 ENOG4106ETB IIa component GTH21_RS26005 ENOG4105KIT UPF0379 protein yjfY GTH21_RS26010 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GTH21_RS26015 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GTH21_RS26020 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GTH21_RS26025 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GTH21_RS26030 ENOG4105FHY Opacity-associated protein A GTH21_RS26035 ENOG4108V1T peptidylprolyl cis-trans isomerase GTH21_RS26045 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GTH21_RS26050 ENOG4105DXC membrane GTH21_RS26060 ENOG4105ECR NmrA family GTH21_RS26065 ENOG4105KVH Transcriptional regulator GTH21_RS26070 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GTH21_RS26075 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GTH21_RS26080 ENOG4108UUE Transcriptional regulator GTH21_RS26085 ENOG41061GZ Protein of unknown function (DUF1107) GTH21_RS26095 ENOG4105C4C beta-galactosidase GTH21_RS26105 ENOG4105C37 (CBS) domain GTH21_RS26115 ENOG4105CFU surface antigen GTH21_RS26120 ENOG4105MA0 exported protein GTH21_RS26125 ENOG4108ZHD aig2 family GTH21_RS26135 ENOG4105F0N pyrophosphate phospho-hydrolase GTH21_RS26140 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GTH21_RS26145 ENOG4105C2J ABC transporter GTH21_RS26150 ENOG4107R9N ABC transporter GTH21_RS26155 ENOG41062B0 ABC transporter, permease GTH21_RS26160 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GTH21_RS26165 ENOG4105DFU Cell wall formation (By similarity) GTH21_RS26185 ENOG4105N42 UPF0307 protein GTH21_RS26190 ENOG4105CMS peptidase U62, modulator of DNA gyrase GTH21_RS26195 ENOG4108XVM Cytochrome b(562) GTH21_RS26230 ENOG41069H0 dihydroorotase EC 3.5.2.3 GTH21_RS26245 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GTH21_RS26250 ENOG4105EMD TRANSCRIPTIONal GTH21_RS26260 ENOG4105K4U addiction module toxin, RelE StbE family GTH21_RS26265 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GTH21_RS26270 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GTH21_RS26290 ENOG4105F8D glycoside hydrolase family 4 GTH21_RS26295 ENOG4105CK1 PTS System GTH21_RS26300 ENOG4105CG3 alpha amylase, catalytic region GTH21_RS26305 ENOG4105C5Y PTS System GTH21_RS26310 ENOG4105D4X repressor GTH21_RS26320 ENOG4105KME endoribonuclease L-psp GTH21_RS26325 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GTH21_RS26330 ENOG4105CXT aspartate transcarbamylase GTH21_RS26345 ENOG4105XEP YhcH YjgK YiaL family protein GTH21_RS26355 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GTH21_RS26360 ENOG4108KPW sugar kinase GTH21_RS26365 ENOG4105CI2 imidazolone-5-propionate hydrolase GTH21_RS26370 ENOG4105CSX c4-dicarboxylate anaerobic carrier GTH21_RS26375 ENOG4105FDP GntR family transcriptional regulator GTH21_RS26385 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) GTH21_RS26390 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GTH21_RS26395 ENOG4108MJ3 acetyltransferase GTH21_RS26400 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GTH21_RS26405 ENOG4105MYG DNA polymerase iii, chi subunit GTH21_RS26410 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GTH21_RS26415 ENOG4108M8S permease YjgP YjgQ family protein GTH21_RS26420 ENOG4108K5H permease YjgP YjgQ family protein GTH21_RS26425 ENOG4105D7A ATP-binding protein GTH21_RS26435 ENOG4105C26 Dehydrogenase GTH21_RS26440 ENOG4105DH8 myo-inositol catabolism GTH21_RS26450 ENOG4105CHC glucokinase (EC 2.7.1.2) GTH21_RS26455 ENOG4105D7K pfkb domain protein GTH21_RS26465 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GTH21_RS26470 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GTH21_RS26475 ENOG4105F0H myo-inositol catabolism protein GTH21_RS26480 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GTH21_RS26490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GTH21_RS26495 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GTH21_RS26500 ENOG4105DRS transport system, permease GTH21_RS26510 ENOG4105DQ4 alcohol dehydrogenase GTH21_RS26515 ENOG4105CHH sulfate transporter GTH21_RS26520 ENOG41077A9 carbonic anhydrase GTH21_RS26575 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GTH21_RS26595 ENOG4105TS0 gtp-binding protein GTH21_RS26605 ENOG4106549 Antirestriction protein GTH21_RS26610 ENOG4108XS9 dna repair protein GTH21_RS26615 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles GTH21_RS26620 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures GTH21_RS26725 ENOG4105DSG hydrolase family 43 GTH21_RS26730 ENOG4105CT4 transporter GTH21_RS26735 ENOG4105C93 Xylose Isomerase GTH21_RS26745 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GTH21_RS26750 ENOG4107SEY Conserved Protein GTH21_RS26770 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GTH21_RS26785 ENOG4107FW0 short-chain dehydrogenase reductase GTH21_RS26795 ENOG4108XDN Transcriptional regulator GTH21_RS26800 ENOG4105QNF Outer membrane lipoprotein GTH21_RS26810 ENOG4108IJF Heavy metal efflux pump, CzcA GTH21_RS26815 ENOG4105EP1 Efflux transporter rnd family, mfp subunit GTH21_RS26820 ENOG410624V efflux system protein GTH21_RS26825 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GTH21_RS26830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GTH21_RS26835 ENOG4105GR3 Histidine kinase GTH21_RS26850 ENOG4105EZE Cupin 4 family protein GTH21_RS26900 ENOG41074AV Hok/gef family GTH21_RS27045 ENOG410620I Diguanylate cyclase GTH21_RS27065 ENOG4108M8H domain protein GTH21_RS27075 ENOG4105C94 Transporter GTH21_RS27120 ENOG410624V efflux system protein GTH21_RS27150 ENOG4105DR5 peptidase GTH21_RS27160 ENOG4105E3B Multicopper oxidase GTH21_RS27165 ENOG4105VR0 copper resistance GTH21_RS27170 ENOG4105JDN Copper resistance protein GTH21_RS27175 ENOG4108PG2 copper resistance GTH21_RS27180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GTH21_RS27185 ENOG4105GR3 Histidine kinase GTH21_RS27205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GTH21_RS27220 ENOG4105CAU Arsenical resistance protein, ArsH GTH21_RS27290 ENOG4105KF5 hemolysin expression-modulating protein GTH21_RS27335 ENOG4105D0M Protease HtpX homolog GTH21_RS27350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GTH21_RS27355 ENOG4105VN1 Heat shock protein GTH21_RS27465 ENOG4108BUD transposase GTH21_RS27475 ENOG4105VUN Transcriptional regulator GTH21_RS27510 ENOG4108Z3N Transcriptional regulator GTH21_RS27750 ENOG4107CBI conjugal transfer fertility inhibition protein GTH21_RS27780 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) GTH21_RS27790 ENOG4106CQM replication GTH21_RS27805 ENOG4108RAV Conserved protein GTH21_RS27835 ENOG41066YJ Beta-lactamase GTH21_RS27845 ENOG4105FQP Beta-lactamase GTH21_RS27860 ENOG4105VMP Transcriptional regulator GTH21_RS27870 ENOG41080IJ Diacylglycerol kinase GTH21_RS27875 ENOG4106F60 Histidine kinase GTH21_RS27890 ENOG4105DIJ Phosphoethanolamine transferase GTH21_RS28010 ENOG4105EKQ RNA-directed DNA polymerase GTH21_RS28025 ENOG4105MPK DNA polymerase III subunit theta GTH21_RS28085 ENOG4105FEQ ParB domain protein nuclease GTH21_RS28110 ENOG41074AV Hok/gef family GTH21_RS28255 ENOG4108BUD transposase GTH21_RS28265 ENOG4105VUN Transcriptional regulator GTH21_RS28315 ENOG4105NNG Peripheral inner membrane phage-shock protein GTH21_RS28320 ENOG4105FM1 phage shock protein C GTH21_RS28325 ENOG4105YYT phage shock protein B GTH21_RS28330 ENOG41087YS Phage shock protein A GTH21_RS28335 ENOG4105E51 psp operon transcriptional activator GTH21_RS28345 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GTH21_RS28350 ENOG4108WTK competence damage-inducible protein GTH21_RS28365 ENOG4108YDI single-species biofilm formation on inanimate substrate GTH21_RS28370 ENOG4108J59 Extracellular solute-binding protein, family 5 GTH21_RS28375 ENOG4108EKA peptide transport system, permease GTH21_RS28455 ENOG4105EKQ RNA-directed DNA polymerase GTH21_RS28470 ENOG4107SKI cobyrinic Acid a,c-diamide synthase GTH21_RS28580 ENOG4108BUD transposase GTH21_RS28685 ENOG4106CQM replication GTH21_RS28710 ENOG4108MA7 Inherit from COG: YD repeat protein GTH21_RS28935 ENOG4108Z3N Transcriptional regulator GTH21_RS29045 ENOG4105EMU Dehydrogenase GTH21_RS29075 ENOG4108BUD transposase GTH21_RS29100 ENOG4108C33 Resolvase GTH21_RS29130 ENOG4105EKQ RNA-directed DNA polymerase GTH21_RS29140 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A GTH21_RS29380 ENOG4105C2U cobyrinic Acid a,c-diamide synthase GTH21_RS29410 ENOG4105K4U addiction module toxin, RelE StbE family GTH21_RS29420 ENOG410607W Transposase