locus-tag	class	description
GTH21_RS00030	COG0842	Transport permease protein
GTH21_RS00035	COG1129	ABC transporter
GTH21_RS00035	COG0842	Transport permease protein
GTH21_RS00040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS00045	COG3706	GGDEF domain
GTH21_RS00070	COG4869	propanediol catabolic process
GTH21_RS00080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GTH21_RS00085	COG1882	Formate acetyltransferase
GTH21_RS00100	COG1454	alcohol dehydrogenase
GTH21_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS00135	COG2249	NAD(P)H dehydrogenase (quinone) activity
GTH21_RS00140	COG0583	DNA-binding transcription factor activity
GTH21_RS00155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTH21_RS00160	COG5457	Domain of unknown function (DUF1127)
GTH21_RS00170	COG1566	PFAM secretion protein HlyD family protein
GTH21_RS00185	COG1924	4 iron, 4 sulfur cluster binding
GTH21_RS00190	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GTH21_RS00205	COG2733	membrane
GTH21_RS00220	COG5464	transposase or invertase
GTH21_RS00225	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS00235	COG0523	cobalamin synthesis protein
GTH21_RS00240	COG2879	small protein
GTH21_RS00245	COG1966	Carbon starvation protein
GTH21_RS00250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GTH21_RS00255	COG2368	4-hydroxyphenylacetate
GTH21_RS00275	COG3971	2-oxopent-4-enoate hydratase activity
GTH21_RS00285	COG3384	dioxygenase
GTH21_RS00320	COG0179	Fumarylacetoacetate (FAA) hydrolase
GTH21_RS00330	COG1846	Transcriptional regulator
GTH21_RS00360	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GTH21_RS00375	COG3734	2-keto-3-deoxy-galactonokinase
GTH21_RS00380	COG0800	Aldolase
GTH21_RS00385	COG1737	Transcriptional regulator
GTH21_RS00395	COG1214	PFAM Peptidase M22, glycoprotease
GTH21_RS00395	COG0456	acetyltransferase
GTH21_RS00400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTH21_RS00400	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GTH21_RS00415	COG3715	PTS system
GTH21_RS00420	COG3716	PTS system mannose fructose sorbose family IID component
GTH21_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTH21_RS00435	COG5464	transposase or invertase
GTH21_RS00450	COG1484	DNA-dependent DNA replication
GTH21_RS00465	COG2966	Psort location CytoplasmicMembrane, score
GTH21_RS00480	COG2197	response regulator
GTH21_RS00485	COG2197	response regulator
GTH21_RS00490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTH21_RS00495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS00495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS00500	COG4114	ferric iron reductase
GTH21_RS00505	COG3706	GGDEF domain
GTH21_RS00540	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
GTH21_RS00545	COG0456	acetyltransferase
GTH21_RS00550	COG1011	Hydrolase
GTH21_RS00560	COG2823	Periplasmic or secreted lipoprotein
GTH21_RS00570	COG4667	esterase of the alpha-beta hydrolase superfamily
GTH21_RS00575	COG0084	hydrolase, TatD family'
GTH21_RS00580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTH21_RS00610	COG3726	membrane protein affecting hemolysin expression
GTH21_RS00615	COG0560	Phosphoserine phosphatase
GTH21_RS00620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GTH21_RS00630	COG0488	(ABC) transporter
GTH21_RS00635	COG0741	lytic transglycosylase activity
GTH21_RS00655	COG2207	Transcriptional regulator
GTH21_RS00655	COG3708	Transcriptional regulator
GTH21_RS00660	COG3045	CreA protein
GTH21_RS00665	COG0745	RESPONSE REGULATOR receiver
GTH21_RS00670	COG2205	protein histidine kinase activity
GTH21_RS00675	COG4452	Inner membrane protein CreD
GTH21_RS00680	COG0745	RESPONSE REGULATOR receiver
GTH21_RS00690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GTH21_RS00705	COG0460	homoserine dehydrogenase
GTH21_RS00705	COG0527	aspartate kinase activity
GTH21_RS00715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GTH21_RS00730	COG1115	amino acid carrier protein
GTH21_RS00735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GTH21_RS00740	COG0521	Mo-molybdopterin cofactor biosynthetic process
GTH21_RS00745	COG0477	Major facilitator Superfamily
GTH21_RS00750	COG1584	GPR1 FUN34 yaaH family protein
GTH21_RS00755	COG4735	regulation of single-species biofilm formation
GTH21_RS00780	COG0583	DNA-binding transcription factor activity
GTH21_RS00800	COG0196	riboflavin kinase activity
GTH21_RS00815	COG1047	Peptidyl-prolyl cis-trans
GTH21_RS00840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTH21_RS00910	COG0505	Belongs to the CarA family
GTH21_RS00955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GTH21_RS00965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GTH21_RS00970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GTH21_RS00985	COG3493	citrate carrier protein
GTH21_RS00995	COG0564	pseudouridine synthase activity
GTH21_RS01005	COG0417	DNA replication proofreading
GTH21_RS01010	COG0235	Class ii aldolase
GTH21_RS01035	COG0586	Pfam SNARE associated Golgi protein
GTH21_RS01045	COG1178	ABC-type Fe3 transport system permease component
GTH21_RS01070	COG2814	Major facilitator Superfamily
GTH21_RS01075	COG2271	Major facilitator Superfamily
GTH21_RS01080	COG0583	DNA-binding transcription factor activity
GTH21_RS01090	COG0738	Major facilitator superfamily
GTH21_RS01140	COG0028	Belongs to the TPP enzyme family
GTH21_RS01150	COG1609	Transcriptional regulator
GTH21_RS01170	COG0768	penicillin binding
GTH21_RS01175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTH21_RS01180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTH21_RS01195	COG0772	Belongs to the SEDS family
GTH21_RS01220	COG0849	cell division
GTH21_RS01225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTH21_RS01245	COG0494	nUDIX hydrolase
GTH21_RS01270	COG1459	type II secretion system
GTH21_RS01275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTH21_RS01280	COG4969	Belongs to the N-Me-Phe pilin family
GTH21_RS01290	COG3023	N-Acetylmuramoyl-L-alanine amidase
GTH21_RS01295	COG3725	Membrane protein required for beta-lactamase induction
GTH21_RS01300	COG3940	Belongs to the glycosyl hydrolase 43 family
GTH21_RS01305	COG2211	Major facilitator Superfamily
GTH21_RS01310	COG1113	amino acid transport
GTH21_RS01315	COG2186	Transcriptional regulator
GTH21_RS01320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GTH21_RS01325	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTH21_RS01330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTH21_RS01345	COG3064	Membrane
GTH21_RS01400	COG2132	Multicopper oxidase
GTH21_RS01405	COG4993	Dehydrogenase
GTH21_RS01420	COG0288	reversible hydration of carbon dioxide
GTH21_RS01425	COG1131	(ABC) transporter
GTH21_RS01430	COG0842	Transport permease protein
GTH21_RS01435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS01440	COG0726	polysaccharide deacetylase
GTH21_RS01460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTH21_RS01465	COG0617	tRNA 3'-terminal CCA addition
GTH21_RS01485	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GTH21_RS01490	COG1643	Atp-dependent helicase
GTH21_RS01585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTH21_RS01590	COG4774	siderophore transport
GTH21_RS01595	COG1120	ATPase activity
GTH21_RS01600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTH21_RS01605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS01625	COG2860	membrane
GTH21_RS01645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTH21_RS01650	COG3835	regulator
GTH21_RS01665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GTH21_RS01670	COG0024	Methionine aminopeptidase
GTH21_RS01695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GTH21_RS01705	COG0575	Belongs to the CDS family
GTH21_RS01710	COG0750	zinc metalloprotease
GTH21_RS01720	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GTH21_RS01765	COG0346	lactoylglutathione lyase activity
GTH21_RS01775	COG4568	rho-dependent transcription termination
GTH21_RS01790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GTH21_RS01795	COG3015	lipoprotein NlpE involved in copper resistance
GTH21_RS01800	COG0791	NLP P60 protein
GTH21_RS01810	COG1720	tRNA m6t6A37 methyltransferase activity
GTH21_RS01820	COG1464	Belongs to the NlpA lipoprotein family
GTH21_RS01825	COG2011	ABC-type metal ion transport system permease component
GTH21_RS01835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GTH21_RS01870	COG0656	L-ascorbic acid biosynthetic process
GTH21_RS01875	COG0583	DNA-binding transcription factor activity
GTH21_RS01880	COG2814	Major facilitator Superfamily
GTH21_RS01890	COG2226	methyltransferase
GTH21_RS01895	COG1388	LysM domain
GTH21_RS01895	COG0741	lytic transglycosylase activity
GTH21_RS01905	COG2226	methyltransferase
GTH21_RS01915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTH21_RS01925	COG0583	DNA-binding transcription factor activity
GTH21_RS01935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTH21_RS01940	COG1960	acyl-CoA dehydrogenase activity
GTH21_RS01950	COG0121	glutamine amidotransferase
GTH21_RS01955	COG3034	peptidoglycan biosynthetic process
GTH21_RS01970	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTH21_RS01975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTH21_RS01990	COG2991	Protein conserved in bacteria
GTH21_RS02005	COG0454	-acetyltransferase
GTH21_RS02010	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTH21_RS02030	COG1802	Transcriptional regulator
GTH21_RS02040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTH21_RS02045	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS02050	COG0579	oxidoreductase
GTH21_RS02065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GTH21_RS02070	COG0625	glutathione transferase activity
GTH21_RS02075	COG3775	system Galactitol-specific IIC component
GTH21_RS02080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTH21_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS02090	COG1070	Carbohydrate kinase
GTH21_RS02110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTH21_RS02115	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTH21_RS02120	COG0022	dehydrogenase e1 component
GTH21_RS02125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GTH21_RS02200	COG1192	Involved in chromosome partitioning
GTH21_RS02205	COG0582	viral genome integration into host DNA
GTH21_RS02230	COG0791	NLP P60 protein
GTH21_RS02250	COG3639	organic phosphonate transmembrane transporter activity
GTH21_RS02260	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GTH21_RS02285	COG3188	usher protein
GTH21_RS02300	COG0765	amino acid transport
GTH21_RS02305	COG0765	amino acid transport
GTH21_RS02310	COG1126	abc transporter atp-binding protein
GTH21_RS02315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS02355	COG4302	ethanolamine ammonia-lyase activity
GTH21_RS02360	COG4303	Ethanolamine ammonia lyase large subunit
GTH21_RS02375	COG0833	amino acid
GTH21_RS02380	COG2040	homocysteine
GTH21_RS02385	COG4521	taurine ABC transporter
GTH21_RS02390	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GTH21_RS02395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTH21_RS02400	COG2175	clavaminate synthase activity
GTH21_RS02410	COG1943	Transposase
GTH21_RS02415	COG0113	porphobilinogen synthase activity
GTH21_RS02420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTH21_RS02425	COG1335	isochorismatase
GTH21_RS02430	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GTH21_RS02470	COG1785	Belongs to the alkaline phosphatase family
GTH21_RS02480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTH21_RS02490	COG3416	Protein conserved in bacteria
GTH21_RS02495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GTH21_RS02505	COG4126	flavin adenine dinucleotide binding
GTH21_RS02520	COG1940	carbohydrate kinase activity
GTH21_RS02525	COG0419	ATPase involved in DNA repair
GTH21_RS02530	COG0420	3'-5' exonuclease activity
GTH21_RS02555	COG0366	Alpha amylase catalytic
GTH21_RS02560	COG0583	DNA-binding transcription factor activity
GTH21_RS02565	COG1335	isochorismatase
GTH21_RS02575	COG1228	amidohydrolase
GTH21_RS02585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS02600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS02610	COG0450	alkyl hydroperoxide reductase
GTH21_RS02635	COG1862	Preprotein translocase
GTH21_RS02640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTH21_RS02645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTH21_RS02665	COG4238	major outer membrane lipoprotein
GTH21_RS02675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTH21_RS02675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTH21_RS02695	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTH21_RS02700	COG0667	Aldo Keto reductase
GTH21_RS02710	COG0142	geranyltranstransferase activity
GTH21_RS02735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTH21_RS02745	COG2814	Major facilitator Superfamily
GTH21_RS02750	COG0673	inositol 2-dehydrogenase activity
GTH21_RS02765	COG1053	succinate dehydrogenase
GTH21_RS02775	COG1053	succinate dehydrogenase
GTH21_RS02780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GTH21_RS02785	COG1414	Transcriptional regulator
GTH21_RS02800	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GTH21_RS02805	COG1845	cytochrome c oxidase, subunit III
GTH21_RS02810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GTH21_RS02815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GTH21_RS02820	COG2223	nitrite transmembrane transporter activity
GTH21_RS02825	COG3056	Lipoprotein
GTH21_RS02830	COG0271	Belongs to the BolA IbaG family
GTH21_RS02855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GTH21_RS02860	COG0776	regulation of translation
GTH21_RS02865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTH21_RS02870	COG1555	photosystem II stabilization
GTH21_RS02875	COG0824	Thioesterase
GTH21_RS02885	COG4533	DNA binding
GTH21_RS02900	COG1522	sequence-specific DNA binding
GTH21_RS02905	COG1132	(ABC) transporter
GTH21_RS02910	COG1132	(ABC) transporter
GTH21_RS02915	COG0347	Belongs to the P(II) protein family
GTH21_RS02920	COG0004	ammonium transporteR
GTH21_RS02925	COG1946	Acyl-CoA thioesterase
GTH21_RS02930	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GTH21_RS02935	COG3695	enzyme binding
GTH21_RS02965	COG2364	Membrane
GTH21_RS02980	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GTH21_RS02995	COG2182	Extracellular solute-binding protein
GTH21_RS03000	COG1175	transmembrane transport
GTH21_RS03005	COG3833	ABC-type maltose transport systems, permease component
GTH21_RS03010	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GTH21_RS03015	COG1874	Beta-galactosidase
GTH21_RS03065	COG0110	maltose O-acetyltransferase activity
GTH21_RS03080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH21_RS03085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS03090	COG1309	transcriptional regulator
GTH21_RS03095	COG1196	nuclear chromosome segregation
GTH21_RS03095	COG3264	Mechanosensitive ion channel
GTH21_RS03100	COG5464	transposase or invertase
GTH21_RS03110	COG3923	Primosomal replication protein n
GTH21_RS03115	COG2832	Protein of unknown function (DUF454)
GTH21_RS03155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS03160	COG4651	solute:proton antiporter activity
GTH21_RS03160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTH21_RS03175	COG2223	nitrite transmembrane transporter activity
GTH21_RS03185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTH21_RS03190	COG3735	TraB family
GTH21_RS03205	COG1585	Membrane protein implicated in regulation of membrane protease activity
GTH21_RS03210	COG0330	HflC and HflK could
GTH21_RS03215	COG4619	ABC transporter
GTH21_RS03220	COG0390	transport system, permease component
GTH21_RS03225	COG3118	belongs to the thioredoxin family
GTH21_RS03230	COG0300	oxidoreductase activity
GTH21_RS03235	COG2755	lipolytic protein G-D-S-L family
GTH21_RS03240	COG4181	ATPase activity
GTH21_RS03245	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GTH21_RS03265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GTH21_RS03270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GTH21_RS03285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTH21_RS03295	COG2501	S4 domain
GTH21_RS03345	COG3539	Fimbrial protein
GTH21_RS03350	COG3121	Chaperone
GTH21_RS03355	COG3188	usher protein
GTH21_RS03370	COG1560	Kdo2-lipid A biosynthetic process
GTH21_RS03380	COG3710	Transcriptional regulator
GTH21_RS03385	COG0531	amino acid
GTH21_RS03390	COG1982	Orn Lys Arg decarboxylase major
GTH21_RS03395	COG3104	oligopeptide transport
GTH21_RS03425	COG0673	inositol 2-dehydrogenase activity
GTH21_RS03440	COG1129	ABC transporter
GTH21_RS03445	COG4211	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS03500	COG1566	PFAM secretion protein HlyD family protein
GTH21_RS03505	COG1120	ATPase activity
GTH21_RS03510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS03545	COG1473	amidohydrolase
GTH21_RS03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS03555	COG0667	Aldo Keto reductase
GTH21_RS03600	COG0531	amino acid
GTH21_RS03610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTH21_RS03615	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS03630	COG1113	amino acid transport
GTH21_RS03635	COG2211	Major facilitator Superfamily
GTH21_RS03645	COG0673	inositol 2-dehydrogenase activity
GTH21_RS03660	COG2771	luxR family
GTH21_RS03675	COG3188	usher protein
GTH21_RS03710	COG0668	transmembrane transport
GTH21_RS03715	COG0477	Major facilitator Superfamily
GTH21_RS03730	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GTH21_RS03730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTH21_RS03735	COG2222	sugar isomerase
GTH21_RS03740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTH21_RS03745	COG3716	PTS system mannose fructose sorbose family IID component
GTH21_RS03755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS03765	COG0778	Nitroreductase
GTH21_RS03770	COG2315	Protein conserved in bacteria
GTH21_RS03820	COG3698	Phosphodiester glycosidase
GTH21_RS03830	COG0697	spore germination
GTH21_RS03845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GTH21_RS03850	COG0765	amino acid transport
GTH21_RS03855	COG4215	(ABC) transporter
GTH21_RS03865	COG4221	oxidoreductase activity
GTH21_RS03875	COG4608	Belongs to the ABC transporter superfamily
GTH21_RS03880	COG0444	Belongs to the ABC transporter superfamily
GTH21_RS03885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH21_RS03890	COG0601	transmembrane transport
GTH21_RS03895	COG0747	negative chemotaxis
GTH21_RS03920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTH21_RS03930	COG0668	transmembrane transport
GTH21_RS03935	COG0583	DNA-binding transcription factor activity
GTH21_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS03960	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS03965	COG1129	ABC transporter
GTH21_RS03975	COG1879	ABC-type sugar transport system periplasmic component
GTH21_RS03980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GTH21_RS03985	COG2390	Transcriptional regulator
GTH21_RS03990	COG3959	Transketolase, thiamine diphosphate binding domain
GTH21_RS03995	COG3958	Transketolase
GTH21_RS04000	COG2977	Belongs to the P-Pant transferase superfamily
GTH21_RS04005	COG4771	TonB-dependent receptor
GTH21_RS04010	COG2382	esterase
GTH21_RS04015	COG3251	PFAM MbtH domain protein
GTH21_RS04020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTH21_RS04020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GTH21_RS04025	COG1120	ATPase activity
GTH21_RS04030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS04035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS04045	COG4592	Periplasmic binding protein
GTH21_RS04050	COG1169	isochorismate synthase
GTH21_RS04055	COG1021	2,3-dihydroxybenzoate-AMP ligase
GTH21_RS04060	COG1535	isochorismatase
GTH21_RS04060	COG3433	isochorismatase activity
GTH21_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS04075	COG1966	Carbon starvation protein
GTH21_RS04080	COG2879	small protein
GTH21_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS04100	COG0371	Dehydrogenase
GTH21_RS04105	COG1129	ABC transporter
GTH21_RS04110	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS04140	COG2271	Major facilitator Superfamily
GTH21_RS04145	COG0483	inositol monophosphate 1-phosphatase activity
GTH21_RS04155	COG0402	S-adenosylhomocysteine deaminase activity
GTH21_RS04165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GTH21_RS04180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTH21_RS04190	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS04195	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS04200	COG1129	ABC transporter
GTH21_RS04225	COG0436	Aminotransferase
GTH21_RS04230	COG1475	DNA binding
GTH21_RS04235	COG3969	phosphoadenosine phosphosulfate
GTH21_RS04240	COG0583	DNA-binding transcription factor activity
GTH21_RS04245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTH21_RS04265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTH21_RS04270	COG3719	Belongs to the RNase T2 family
GTH21_RS04275	COG3069	C4-dicarboxylate transmembrane transporter activity
GTH21_RS04295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTH21_RS04310	COG0583	DNA-binding transcription factor activity
GTH21_RS04325	COG1686	Belongs to the peptidase S11 family
GTH21_RS04330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTH21_RS04335	COG0772	Belongs to the SEDS family
GTH21_RS04340	COG0768	penicillin binding
GTH21_RS04350	COG0799	negative regulation of ribosome biogenesis
GTH21_RS04365	COG1466	dna polymerase III delta subunit
GTH21_RS04380	COG2888	peptidyl-tyrosine sulfation
GTH21_RS04395	COG1126	abc transporter atp-binding protein
GTH21_RS04400	COG0765	amino acid transport
GTH21_RS04405	COG0765	amino acid transport
GTH21_RS04420	COG4535	Mg2 and Co2 transporter CorC
GTH21_RS04430	COG1702	phosphate starvation-inducible protein PhoH
GTH21_RS04440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTH21_RS04480	COG0367	asparagine synthase
GTH21_RS04485	COG0647	UMP catabolic process
GTH21_RS04490	COG1846	Transcriptional regulator
GTH21_RS04490	COG1940	carbohydrate kinase activity
GTH21_RS04495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTH21_RS04535	COG0735	belongs to the Fur family
GTH21_RS04550	COG0596	Alpha beta hydrolase
GTH21_RS04560	COG0033	Phosphoglucomutase
GTH21_RS04575	COG2205	protein histidine kinase activity
GTH21_RS04605	COG0415	Belongs to the DNA photolyase family
GTH21_RS04620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GTH21_RS04625	COG1984	allophanate hydrolase subunit 2
GTH21_RS04660	COG2009	succinate dehydrogenase
GTH21_RS04665	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GTH21_RS04670	COG1053	succinate dehydrogenase
GTH21_RS04675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GTH21_RS04680	COG0567	Dehydrogenase, E1 component
GTH21_RS04685	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTH21_RS04695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GTH21_RS04705	COG1271	oxidase subunit
GTH21_RS04710	COG1294	oxidase, subunit
GTH21_RS04715	COG4890	Cyd operon protein YbgT
GTH21_RS04720	COG3790	cyd operon protein YbgE
GTH21_RS04725	COG0824	Thioesterase
GTH21_RS04730	COG0811	peptide transport
GTH21_RS04735	COG0848	biopolymer transport protein
GTH21_RS04740	COG3064	Membrane
GTH21_RS04750	COG2885	chlorophyll binding
GTH21_RS04755	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GTH21_RS04800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GTH21_RS04805	COG3201	nicotinamide mononucleotide transporter
GTH21_RS04820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTH21_RS04830	COG2017	converts alpha-aldose to the beta-anomer
GTH21_RS04840	COG1085	galactose-1-phosphate uridylyltransferase
GTH21_RS04855	COG1119	ATPase activity
GTH21_RS04865	COG2005	Transcriptional regulator
GTH21_RS04865	COG3585	molybdate ion transport
GTH21_RS04875	COG0725	ABC transporter, periplasmic molybdate-binding protein
GTH21_RS04880	COG4149	molybdate abc transporter
GTH21_RS04885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GTH21_RS04890	COG0561	phosphatase activity
GTH21_RS04915	COG2200	EAL domain
GTH21_RS04920	COG0789	Transcriptional regulator
GTH21_RS04955	COG4677	pectinesterase activity
GTH21_RS04995	COG1881	PFAM PEBP family protein
GTH21_RS05000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTH21_RS05015	COG2226	methyltransferase
GTH21_RS05040	COG0642	Histidine kinase
GTH21_RS05045	COG0745	RESPONSE REGULATOR receiver
GTH21_RS05065	COG0521	Mo-molybdopterin cofactor biosynthetic process
GTH21_RS05075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GTH21_RS05080	COG0314	molybdopterin synthase activity
GTH21_RS05085	COG0670	Belongs to the BI1 family
GTH21_RS05090	COG0392	lysyltransferase activity
GTH21_RS05095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTH21_RS05100	COG3568	Endonuclease Exonuclease Phosphatase
GTH21_RS05110	COG0842	Transport permease protein
GTH21_RS05115	COG0842	Transport permease protein
GTH21_RS05120	COG1131	(ABC) transporter
GTH21_RS05125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS05130	COG1309	transcriptional regulator
GTH21_RS05135	COG0583	DNA-binding transcription factor activity
GTH21_RS05145	COG2271	Major facilitator Superfamily
GTH21_RS05150	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS05155	COG3959	Transketolase, thiamine diphosphate binding domain
GTH21_RS05160	COG3958	Transketolase
GTH21_RS05165	COG0513	Belongs to the DEAD box helicase family
GTH21_RS05170	COG1199	ATP-dependent helicase activity
GTH21_RS05175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GTH21_RS05185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GTH21_RS05195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GTH21_RS05205	COG0668	transmembrane transport
GTH21_RS05210	COG1126	abc transporter atp-binding protein
GTH21_RS05215	COG0765	amino acid transport
GTH21_RS05220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS05240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GTH21_RS05245	COG2194	sulfuric ester hydrolase activity
GTH21_RS05255	COG1321	iron dependent repressor
GTH21_RS05260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTH21_RS05265	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS05270	COG2188	Transcriptional regulator
GTH21_RS05275	COG1376	ErfK ybiS ycfS ynhG family protein
GTH21_RS05280	COG2365	Tyrosine phosphatase family
GTH21_RS05285	COG0488	(ABC) transporter
GTH21_RS05295	COG2271	Major facilitator Superfamily
GTH21_RS05300	COG1609	Transcriptional regulator
GTH21_RS05310	COG0561	phosphatase activity
GTH21_RS05315	COG1882	Formate acetyltransferase
GTH21_RS05320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GTH21_RS05325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTH21_RS05330	COG0303	'Molybdopterin
GTH21_RS05345	COG0747	negative chemotaxis
GTH21_RS05365	COG2223	nitrite transmembrane transporter activity
GTH21_RS05375	COG2133	pyrroloquinoline quinone binding
GTH21_RS05380	COG0625	glutathione transferase activity
GTH21_RS05390	COG1686	Belongs to the peptidase S11 family
GTH21_RS05395	COG1349	DNA-binding transcription factor activity
GTH21_RS05400	COG0671	phosphoesterase, PA-phosphatase related
GTH21_RS05405	COG2814	Major facilitator Superfamily
GTH21_RS05410	COG0561	phosphatase activity
GTH21_RS05415	COG0738	Major facilitator superfamily
GTH21_RS05420	COG3226	Transcriptional regulator
GTH21_RS05425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GTH21_RS05455	COG4695	Portal protein
GTH21_RS05660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTH21_RS05665	COG3842	ATPase activity
GTH21_RS05670	COG1176	ABC-type spermidine putrescine transport system, permease component I
GTH21_RS05675	COG1177	transmembrane transport
GTH21_RS05690	COG0745	RESPONSE REGULATOR receiver
GTH21_RS05695	COG5002	protein histidine kinase activity
GTH21_RS05700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS05705	COG4160	amino acid transport
GTH21_RS05710	COG4215	(ABC) transporter
GTH21_RS05715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS05720	COG1126	abc transporter atp-binding protein
GTH21_RS05730	COG2203	Gaf domain
GTH21_RS05730	COG3706	GGDEF domain
GTH21_RS05730	COG4251	negative regulation of phosphorylation
GTH21_RS05730	COG5001	Diguanylate cyclase
GTH21_RS05735	COG3023	N-Acetylmuramoyl-L-alanine amidase
GTH21_RS05740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTH21_RS05745	COG0702	epimerase
GTH21_RS05750	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GTH21_RS05755	COG0028	Belongs to the TPP enzyme family
GTH21_RS05765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTH21_RS05775	COG2431	L-lysine efflux transmembrane transporter activity
GTH21_RS05785	COG3593	DNA synthesis involved in DNA repair
GTH21_RS05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS05800	COG1278	Cold shock
GTH21_RS05810	COG0542	response to heat
GTH21_RS05825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GTH21_RS05830	COG4988	ABC transporter
GTH21_RS05835	COG0492	ferredoxin-NADP+ reductase activity
GTH21_RS05850	COG1178	ABC-type Fe3 transport system permease component
GTH21_RS05850	COG1674	ftsk spoiiie
GTH21_RS05860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTH21_RS05870	COG0243	molybdopterin cofactor binding
GTH21_RS05875	COG0437	4 iron, 4 sulfur cluster binding
GTH21_RS05880	COG3302	dmso reductase anchor subunit
GTH21_RS05890	COG0477	Major facilitator Superfamily
GTH21_RS05895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GTH21_RS05900	COG1882	Formate acetyltransferase
GTH21_RS05905	COG2116	formate transmembrane transporter activity
GTH21_RS05910	COG1944	ATP diphosphatase activity
GTH21_RS05915	COG2323	membrane
GTH21_RS05935	COG0539	negative regulation of cytoplasmic translation
GTH21_RS05945	COG0658	competence protein
GTH21_RS05945	COG2333	competence protein COMEC
GTH21_RS05960	COG3214	Protein conserved in bacteria
GTH21_RS05975	COG3173	Aminoglycoside phosphotransferase
GTH21_RS05980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTH21_RS05985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTH21_RS05995	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GTH21_RS06005	COG2989	Protein conserved in bacteria
GTH21_RS06010	COG3108	Peptidase M15
GTH21_RS06015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTH21_RS06020	COG1448	Aminotransferase
GTH21_RS06045	COG0814	amino acid
GTH21_RS06055	COG1473	amidohydrolase
GTH21_RS06065	COG0308	aminopeptidase N
GTH21_RS06075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTH21_RS06080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTH21_RS06085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTH21_RS06090	COG0431	NADPH-dependent FMN reductase
GTH21_RS06105	COG0633	Ferredoxin
GTH21_RS06105	COG3217	Mosc domain protein beta barrel domain protein
GTH21_RS06115	COG0488	(ABC) transporter
GTH21_RS06120	COG2995	paraquat-inducible protein a
GTH21_RS06125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTH21_RS06125	COG3008	intermembrane lipid transfer
GTH21_RS06130	COG3009	Protein conserved in bacteria
GTH21_RS06135	COG3130	regulation of translation
GTH21_RS06145	COG1067	ATP-dependent peptidase activity
GTH21_RS06165	COG3070	regulator of competence-specific genes
GTH21_RS06170	COG1289	transmembrane transporter activity
GTH21_RS06175	COG3304	Inner membrane component domain
GTH21_RS06180	COG0210	DNA helicase
GTH21_RS06190	COG1832	CoA-binding protein
GTH21_RS06205	COG1881	PFAM PEBP family protein
GTH21_RS06210	COG2207	Transcriptional regulator
GTH21_RS06225	COG0670	Belongs to the BI1 family
GTH21_RS06240	COG2200	EAL domain
GTH21_RS06245	COG2200	EAL domain
GTH21_RS06255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTH21_RS06260	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS06265	COG4638	Rieske (2fe-2S)
GTH21_RS06270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTH21_RS06275	COG0473	3-isopropylmalate dehydrogenase activity
GTH21_RS06280	COG0583	DNA-binding transcription factor activity
GTH21_RS06285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTH21_RS06290	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS06295	COG1917	Cupin 2, conserved barrel domain protein
GTH21_RS06295	COG1396	sequence-specific DNA binding
GTH21_RS06300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GTH21_RS06305	COG0174	glutamine synthetase
GTH21_RS06310	COG0531	amino acid
GTH21_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS06355	COG3729	General stress protein
GTH21_RS06365	COG2233	PERMEase
GTH21_RS06400	COG1309	transcriptional regulator
GTH21_RS06415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTH21_RS06430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTH21_RS06450	COG1702	phosphate starvation-inducible protein PhoH
GTH21_RS06455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTH21_RS06475	COG0583	DNA-binding transcription factor activity
GTH21_RS06505	COG3381	protein complex oligomerization
GTH21_RS06540	COG5645	(Lipo)protein
GTH21_RS06555	COG1560	Kdo2-lipid A biosynthetic process
GTH21_RS06615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH21_RS06635	COG2814	Major facilitator Superfamily
GTH21_RS06640	COG0583	DNA-binding transcription factor activity
GTH21_RS06645	COG1530	ribonuclease E activity
GTH21_RS06665	COG1399	metal-binding, possibly nucleic acid-binding protein
GTH21_RS06685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GTH21_RS06700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTH21_RS06705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTH21_RS06710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GTH21_RS06720	COG0470	DNA polymerase III
GTH21_RS06725	COG0084	hydrolase, TatD family'
GTH21_RS06735	COG0537	adenosine 5'-monophosphoramidase activity
GTH21_RS06740	COG5633	Lipoprotein
GTH21_RS06765	COG1252	NADH dehydrogenase
GTH21_RS06770	COG3134	Outer membrane lipoprotein
GTH21_RS06785	COG1309	transcriptional regulator
GTH21_RS06800	COG1388	LysM domain
GTH21_RS06800	COG1376	ErfK ybiS ycfS ynhG family protein
GTH21_RS06805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTH21_RS06815	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTH21_RS06825	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTH21_RS06835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTH21_RS06845	COG0318	PFAM AMP-dependent synthetase and ligase
GTH21_RS06860	COG1177	transmembrane transport
GTH21_RS06880	COG2850	peptidyl-arginine hydroxylation
GTH21_RS06885	COG2205	protein histidine kinase activity
GTH21_RS06905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTH21_RS06925	COG1187	pseudouridine synthase activity
GTH21_RS06930	COG0538	isocitrate dehydrogenase activity
GTH21_RS06935	COG0582	viral genome integration into host DNA
GTH21_RS06975	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GTH21_RS06980	COG5532	Uncharacterized conserved protein (DUF2303)
GTH21_RS06995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTH21_RS07000	COG4197	protein conserved in bacteria, prophage-related
GTH21_RS07015	COG4626	Terminase
GTH21_RS07015	COG1802	Transcriptional regulator
GTH21_RS07025	COG4725	Belongs to the MT-A70-like family
GTH21_RS07035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTH21_RS07050	COG1403	HNH endonuclease
GTH21_RS07055	COG0484	heat shock protein binding
GTH21_RS07095	COG3179	chitinase
GTH21_RS07235	COG3344	reverse transcriptase
GTH21_RS07270	COG0538	isocitrate dehydrogenase activity
GTH21_RS07275	COG0640	Transcriptional regulator
GTH21_RS07295	COG3813	Protein conserved in bacteria
GTH21_RS07300	COG1063	alcohol dehydrogenase
GTH21_RS07305	COG3729	General stress protein
GTH21_RS07310	COG3685	Protein conserved in bacteria
GTH21_RS07315	COG3685	Protein conserved in bacteria
GTH21_RS07320	COG3546	catalase activity
GTH21_RS07325	COG1271	oxidase subunit
GTH21_RS07330	COG1294	oxidase, subunit
GTH21_RS07360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GTH21_RS07370	COG3706	GGDEF domain
GTH21_RS07375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTH21_RS07390	COG1560	Kdo2-lipid A biosynthetic process
GTH21_RS07400	COG3182	Iron-regulated membrane protein
GTH21_RS07420	COG2199	diguanylate cyclase activity
GTH21_RS07420	COG2203	Gaf domain
GTH21_RS07425	COG3042	response to heat
GTH21_RS07430	COG3189	MarR family transcriptional regulator
GTH21_RS07435	COG1683	Conserved Protein
GTH21_RS07440	COG0504	CTP synthase activity
GTH21_RS07445	COG2807	transmembrane transport
GTH21_RS07450	COG2207	Transcriptional regulator
GTH21_RS07460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTH21_RS07465	COG0859	PFAM glycosyl transferase family 9
GTH21_RS07480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTH21_RS07485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTH21_RS07490	COG0583	DNA-binding transcription factor activity
GTH21_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS07520	COG0386	Belongs to the glutathione peroxidase family
GTH21_RS07535	COG2766	serine protein kinase
GTH21_RS07540	COG3713	MltA-interacting MipA family protein
GTH21_RS07545	COG0656	L-ascorbic acid biosynthetic process
GTH21_RS07565	COG3139	Protein of unknown function (DUF1315)
GTH21_RS07580	COG1063	alcohol dehydrogenase
GTH21_RS07585	COG2271	Major facilitator Superfamily
GTH21_RS07590	COG1063	alcohol dehydrogenase
GTH21_RS07595	COG0191	fructose-bisphosphate aldolase activity
GTH21_RS07600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS07605	COG0667	Aldo Keto reductase
GTH21_RS07610	COG1349	DNA-binding transcription factor activity
GTH21_RS07615	COG2814	Major facilitator Superfamily
GTH21_RS07620	COG1335	isochorismatase
GTH21_RS07625	COG0252	asparaginase activity
GTH21_RS07630	COG0616	signal peptide processing
GTH21_RS07635	COG0778	Nitroreductase
GTH21_RS07650	COG0709	Synthesizes selenophosphate from selenide and ATP
GTH21_RS07660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTH21_RS07665	COG3321	synthase
GTH21_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS07665	COG0604	alcohol dehydrogenase
GTH21_RS07670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GTH21_RS07675	COG0494	nUDIX hydrolase
GTH21_RS07680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTH21_RS07685	COG2897	thiosulfate sulfurtransferase activity
GTH21_RS07690	COG4136	ATPase activity
GTH21_RS07695	COG4135	transport system, permease component
GTH21_RS07700	COG4134	Bacterial extracellular solute-binding protein
GTH21_RS07705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTH21_RS07710	COG0398	Pfam SNARE associated Golgi protein
GTH21_RS07715	COG0398	Pfam SNARE associated Golgi protein
GTH21_RS07720	COG0708	Exodeoxyribonuclease III
GTH21_RS07730	COG3138	arginine N-succinyltransferase
GTH21_RS07740	COG3724	N-succinylarginine dihydrolase activity
GTH21_RS07750	COG3678	ATP-independent chaperone mediated protein folding
GTH21_RS07755	COG0322	excinuclease ABC activity
GTH21_RS07765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTH21_RS07770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS07795	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTH21_RS07800	COG2169	Transcriptional regulator
GTH21_RS07800	COG1917	Cupin 2, conserved barrel domain protein
GTH21_RS07805	COG1486	melibiose metabolic process
GTH21_RS07815	COG0753	catalase activity
GTH21_RS07830	COG1988	membrane-bound metal-dependent
GTH21_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS07840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH21_RS07870	COG0727	PFAM Uncharacterised protein family (UPF0153)
GTH21_RS07875	COG3047	cAMP biosynthetic process
GTH21_RS07885	COG4774	siderophore transport
GTH21_RS07940	COG0135	phosphoribosylanthranilate isomerase activity
GTH21_RS07940	COG0134	indole-3-glycerol-phosphate synthase activity
GTH21_RS07945	COG0512	Glutamine amidotransferase of anthranilate synthase
GTH21_RS07945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GTH21_RS07950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTH21_RS07960	COG0009	L-threonylcarbamoyladenylate synthase
GTH21_RS07970	COG0583	DNA-binding transcription factor activity
GTH21_RS07980	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GTH21_RS07985	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS07995	COG0616	signal peptide processing
GTH21_RS08020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GTH21_RS08030	COG0671	phosphoesterase, PA-phosphatase related
GTH21_RS08035	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GTH21_RS08040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GTH21_RS08050	COG0023	Translation Initiation Factor
GTH21_RS08065	COG1349	DNA-binding transcription factor activity
GTH21_RS08080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTH21_RS08080	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTH21_RS08085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTH21_RS08095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GTH21_RS08110	COG4171	peptide transport system, permease
GTH21_RS08180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTH21_RS08185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTH21_RS08195	COG2135	peptidase activity
GTH21_RS08210	COG0702	epimerase
GTH21_RS08225	COG1473	amidohydrolase
GTH21_RS08235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTH21_RS08240	COG1842	Phage shock protein A
GTH21_RS08250	COG1983	PspC domain protein
GTH21_RS08260	COG3106	COG3106 Predicted ATPase
GTH21_RS08270	COG0583	DNA-binding transcription factor activity
GTH21_RS08275	COG1486	melibiose metabolic process
GTH21_RS08285	COG3180	Ammonia monooxygenase
GTH21_RS08290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTH21_RS08295	COG4948	Mandelate Racemase Muconate Lactonizing
GTH21_RS08300	COG2866	Carboxypeptidase
GTH21_RS08310	COG4166	transmembrane transport
GTH21_RS08340	COG0656	L-ascorbic acid biosynthetic process
GTH21_RS08360	COG0583	DNA-binding transcription factor activity
GTH21_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS08370	COG1078	dGTPase activity
GTH21_RS08375	COG0693	protein deglycase activity
GTH21_RS08405	COG2885	chlorophyll binding
GTH21_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS08515	COG1309	transcriptional regulator
GTH21_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS08540	COG0583	DNA-binding transcription factor activity
GTH21_RS08570	COG0604	alcohol dehydrogenase
GTH21_RS08590	COG2011	ABC-type metal ion transport system permease component
GTH21_RS08595	COG1448	Aminotransferase
GTH21_RS08605	COG1522	sequence-specific DNA binding
GTH21_RS08610	COG1113	amino acid transport
GTH21_RS08625	COG0673	inositol 2-dehydrogenase activity
GTH21_RS08630	COG1349	DNA-binding transcription factor activity
GTH21_RS08640	COG0513	Belongs to the DEAD box helicase family
GTH21_RS08650	COG0589	response to stress
GTH21_RS08660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTH21_RS08665	COG1013	pyruvate-flavodoxin oxidoreductase activity
GTH21_RS08665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GTH21_RS08665	COG0674	pyruvate-flavodoxin oxidoreductase activity
GTH21_RS08665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTH21_RS08670	COG3042	response to heat
GTH21_RS08675	COG3187	Heat shock protein
GTH21_RS08680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTH21_RS08685	COG0586	Pfam SNARE associated Golgi protein
GTH21_RS08690	COG2911	Protein conserved in bacteria
GTH21_RS08700	COG3784	Protein of unknown function (DUF1318)
GTH21_RS08705	COG2207	Transcriptional regulator
GTH21_RS08710	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS08730	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS08730	COG2030	dehydratase
GTH21_RS08735	COG3396	Phenylacetate-CoA oxygenase
GTH21_RS08740	COG3460	Phenylacetate-CoA oxygenase
GTH21_RS08745	COG3396	Phenylacetate-CoA oxygenase
GTH21_RS08750	COG2151	metal-sulfur cluster biosynthetic enzyme
GTH21_RS08755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTH21_RS08760	COG1024	Enoyl-CoA hydratase
GTH21_RS08765	COG1024	Enoyl-CoA hydratase
GTH21_RS08770	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTH21_RS08775	COG2050	protein possibly involved in aromatic compounds catabolism
GTH21_RS08780	COG0183	Belongs to the thiolase family
GTH21_RS08785	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GTH21_RS08790	COG3327	negative regulation of DNA-templated transcription, initiation
GTH21_RS08795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTH21_RS08810	COG1643	Atp-dependent helicase
GTH21_RS08815	COG4122	O-methyltransferase activity
GTH21_RS08840	COG0583	DNA-binding transcription factor activity
GTH21_RS08845	COG0667	Aldo Keto reductase
GTH21_RS08850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GTH21_RS08860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTH21_RS08865	COG3138	arginine N-succinyltransferase
GTH21_RS08870	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS08875	COG3724	N-succinylarginine dihydrolase activity
GTH21_RS08880	COG2988	succinylglutamate desuccinylase activity
GTH21_RS08885	COG1113	amino acid transport
GTH21_RS08890	COG0477	Major facilitator Superfamily
GTH21_RS08895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTH21_RS08905	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS08910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTH21_RS08915	COG0401	homolog of Blt101
GTH21_RS08920	COG5562	phage envelope protein
GTH21_RS08925	COG0425	Belongs to the sulfur carrier protein TusA family
GTH21_RS08930	COG2391	methyltransferase activity
GTH21_RS08955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GTH21_RS08960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS08960	COG1263	PTS System
GTH21_RS08965	COG1609	Transcriptional regulator
GTH21_RS08970	COG5339	Protein conserved in bacteria
GTH21_RS08975	COG1482	cell wall glycoprotein biosynthetic process
GTH21_RS08980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GTH21_RS08980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GTH21_RS08985	COG0114	fumarate hydratase activity
GTH21_RS08995	COG2205	protein histidine kinase activity
GTH21_RS09005	COG0745	RESPONSE REGULATOR receiver
GTH21_RS09010	COG3136	membrane protein required for alginate biosynthesis
GTH21_RS09020	COG0531	amino acid
GTH21_RS09040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GTH21_RS09045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GTH21_RS09060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTH21_RS09075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GTH21_RS09080	COG1473	amidohydrolase
GTH21_RS09090	COG0583	DNA-binding transcription factor activity
GTH21_RS09095	COG2840	Smr protein MutS2
GTH21_RS09100	COG1414	Transcriptional regulator
GTH21_RS09110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GTH21_RS09115	COG0183	Belongs to the thiolase family
GTH21_RS09125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GTH21_RS09130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTH21_RS09140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GTH21_RS09140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GTH21_RS09160	COG4565	transcriptional regulatory protein
GTH21_RS09165	COG3290	protein histidine kinase activity
GTH21_RS09190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GTH21_RS09200	COG0679	Auxin Efflux Carrier
GTH21_RS09230	COG0628	permease
GTH21_RS09250	COG3591	Belongs to the peptidase S1B family
GTH21_RS09270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GTH21_RS09275	COG2814	Major facilitator Superfamily
GTH21_RS09280	COG0583	DNA-binding transcription factor activity
GTH21_RS09285	COG1940	carbohydrate kinase activity
GTH21_RS09290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GTH21_RS09305	COG3302	dmso reductase anchor subunit
GTH21_RS09310	COG0437	4 iron, 4 sulfur cluster binding
GTH21_RS09315	COG0243	molybdopterin cofactor binding
GTH21_RS09330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH21_RS09345	COG2271	Major facilitator Superfamily
GTH21_RS09350	COG0246	Mannitol dehydrogenase
GTH21_RS09355	COG0589	response to stress
GTH21_RS09360	COG1802	Transcriptional regulator
GTH21_RS09365	COG4221	oxidoreductase activity
GTH21_RS09380	COG2207	Transcriptional regulator
GTH21_RS09385	COG2135	peptidase activity
GTH21_RS09400	COG2197	response regulator
GTH21_RS09415	COG0071	Belongs to the small heat shock protein (HSP20) family
GTH21_RS09420	COG1546	Belongs to the CinA family
GTH21_RS09425	COG2200	EAL domain
GTH21_RS09440	COG2207	Transcriptional regulator
GTH21_RS09440	COG3708	Transcriptional regulator
GTH21_RS09445	COG2610	gluconate transmembrane transporter activity
GTH21_RS09450	COG3622	Belongs to the hyi family
GTH21_RS09455	COG0235	Class ii aldolase
GTH21_RS09460	COG3395	kinase activity
GTH21_RS09465	COG2084	Dehydrogenase
GTH21_RS09470	COG1349	DNA-binding transcription factor activity
GTH21_RS09485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTH21_RS09490	COG2223	nitrite transmembrane transporter activity
GTH21_RS09535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTH21_RS09540	COG0683	leucine binding
GTH21_RS09555	COG1129	ABC transporter
GTH21_RS09560	COG0410	ABC transporter
GTH21_RS09570	COG2814	Major facilitator Superfamily
GTH21_RS09575	COG0697	spore germination
GTH21_RS09585	COG4977	sequence-specific DNA binding
GTH21_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS09620	COG2731	YhcH YjgK YiaL family protein
GTH21_RS09635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTH21_RS09645	COG3395	kinase activity
GTH21_RS09650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GTH21_RS09655	COG1349	DNA-binding transcription factor activity
GTH21_RS09660	COG0039	L-malate dehydrogenase activity
GTH21_RS09670	COG0583	DNA-binding transcription factor activity
GTH21_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS09690	COG2199	diguanylate cyclase activity
GTH21_RS09760	COG0477	Major facilitator Superfamily
GTH21_RS09775	COG2070	2-Nitropropane dioxygenase
GTH21_RS09780	COG2011	ABC-type metal ion transport system permease component
GTH21_RS09800	COG4628	conserved protein (DUF2132)
GTH21_RS09815	COG2207	Transcriptional regulator
GTH21_RS09845	COG2233	PERMEase
GTH21_RS09850	COG3195	allantoin biosynthetic process
GTH21_RS09850	COG3648	Uricase
GTH21_RS09855	COG2351	hydroxyisourate hydrolase activity
GTH21_RS09860	COG1396	sequence-specific DNA binding
GTH21_RS09865	COG3550	peptidyl-serine autophosphorylation
GTH21_RS09880	COG3188	usher protein
GTH21_RS09915	COG3300	MHYT domain
GTH21_RS09915	COG5001	Diguanylate cyclase
GTH21_RS09920	COG2819	hydrolase of the alpha beta superfamily
GTH21_RS09940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS09940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS09945	COG2814	Major facilitator Superfamily
GTH21_RS09960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS09960	COG1263	PTS System
GTH21_RS09965	COG2186	Transcriptional regulator
GTH21_RS09985	COG3835	regulator
GTH21_RS09990	COG1929	Belongs to the glycerate kinase type-1 family
GTH21_RS10035	COG0738	Major facilitator superfamily
GTH21_RS10040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS10045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTH21_RS10050	COG1349	DNA-binding transcription factor activity
GTH21_RS10065	COG1349	DNA-binding transcription factor activity
GTH21_RS10070	COG4977	sequence-specific DNA binding
GTH21_RS10090	COG4977	sequence-specific DNA binding
GTH21_RS10105	COG2801	Transposase and inactivated derivatives
GTH21_RS10120	COG0667	Aldo Keto reductase
GTH21_RS10130	COG0667	Aldo Keto reductase
GTH21_RS10135	COG0667	Aldo Keto reductase
GTH21_RS10145	COG0456	acetyltransferase
GTH21_RS10145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GTH21_RS10170	COG0426	domain, Protein
GTH21_RS10170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GTH21_RS10185	COG1652	LysM domain
GTH21_RS10215	COG1609	Transcriptional regulator
GTH21_RS10225	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS10240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTH21_RS10250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTH21_RS10255	COG0583	DNA-binding transcription factor activity
GTH21_RS10260	COG0583	DNA-binding transcription factor activity
GTH21_RS10275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GTH21_RS10275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH21_RS10275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH21_RS10280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH21_RS10290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTH21_RS10295	COG3037	sugar-specific permease SgaT UlaA
GTH21_RS10305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS10310	COG1609	Transcriptional regulator
GTH21_RS10320	COG2223	nitrite transmembrane transporter activity
GTH21_RS10350	COG0477	Major facilitator Superfamily
GTH21_RS10355	COG4529	Protein conserved in bacteria
GTH21_RS10360	COG1902	pentaerythritol trinitrate reductase activity
GTH21_RS10370	COG0583	DNA-binding transcription factor activity
GTH21_RS10375	COG2070	2-Nitropropane dioxygenase
GTH21_RS10385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTH21_RS10465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTH21_RS10510	COG1335	isochorismatase
GTH21_RS10555	COG1953	Uracil, thiamine, allantoin
GTH21_RS10560	COG0402	S-adenosylhomocysteine deaminase activity
GTH21_RS10565	COG3706	GGDEF domain
GTH21_RS10570	COG1609	Transcriptional regulator
GTH21_RS10580	COG0673	inositol 2-dehydrogenase activity
GTH21_RS10595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GTH21_RS10600	COG1116	anion transmembrane transporter activity
GTH21_RS10605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTH21_RS10610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTH21_RS10615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTH21_RS10620	COG0076	glutamate decarboxylase activity
GTH21_RS10635	COG2205	protein histidine kinase activity
GTH21_RS10640	COG0745	RESPONSE REGULATOR receiver
GTH21_RS10645	COG0596	Alpha beta hydrolase
GTH21_RS10690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GTH21_RS10690	COG0519	Catalyzes the synthesis of GMP from XMP
GTH21_RS10710	COG0583	DNA-binding transcription factor activity
GTH21_RS10720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GTH21_RS10725	COG1285	pathogenesis
GTH21_RS10730	COG2814	Major facilitator Superfamily
GTH21_RS10735	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTH21_RS10740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS10765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS10770	COG0583	DNA-binding transcription factor activity
GTH21_RS10775	COG0243	molybdopterin cofactor binding
GTH21_RS10780	COG3781	membrane
GTH21_RS10805	COG1764	response to oxidative stress
GTH21_RS10815	COG3111	PFAM Bacterial OB fold (BOF) protein
GTH21_RS10825	COG2323	membrane
GTH21_RS10835	COG0366	Alpha amylase catalytic
GTH21_RS10845	COG3685	Protein conserved in bacteria
GTH21_RS10855	COG3729	General stress protein
GTH21_RS10860	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS10905	COG0488	(ABC) transporter
GTH21_RS10920	COG1064	alcohol dehydrogenase
GTH21_RS10925	COG0747	negative chemotaxis
GTH21_RS10945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTH21_RS10955	COG2814	Major facilitator Superfamily
GTH21_RS10965	COG2326	polyphosphate kinase activity
GTH21_RS10980	COG2864	formate dehydrogenase
GTH21_RS10985	COG0437	4 iron, 4 sulfur cluster binding
GTH21_RS11010	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GTH21_RS11020	COG3485	protocatechuate 3,4-dioxygenase
GTH21_RS11025	COG4829	muconolactone delta-isomerase
GTH21_RS11030	COG4948	Mandelate Racemase Muconate Lactonizing
GTH21_RS11035	COG1414	Transcriptional regulator
GTH21_RS11055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GTH21_RS11060	COG1140	nitrate reductase beta subunit
GTH21_RS11065	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GTH21_RS11070	COG2181	nitrate reductase activity
GTH21_RS11075	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GTH21_RS11080	COG1178	ABC-type Fe3 transport system permease component
GTH21_RS11085	COG1840	ABC-type Fe3 transport system, periplasmic component
GTH21_RS11090	COG3842	ATPase activity
GTH21_RS11095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GTH21_RS11130	COG0625	glutathione transferase activity
GTH21_RS11140	COG1126	abc transporter atp-binding protein
GTH21_RS11145	COG0765	amino acid transport
GTH21_RS11160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTH21_RS11165	COG1473	amidohydrolase
GTH21_RS11170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTH21_RS11175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GTH21_RS11200	COG4772	TonB-dependent receptor
GTH21_RS11205	COG1228	amidohydrolase
GTH21_RS11210	COG3691	Protein conserved in bacteria
GTH21_RS11225	COG2130	NADP-dependent
GTH21_RS11235	COG1247	-acetyltransferase
GTH21_RS11240	COG3238	Protein conserved in bacteria
GTH21_RS11250	COG0747	negative chemotaxis
GTH21_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS11295	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS11300	COG1177	transmembrane transport
GTH21_RS11305	COG1176	ABC-type spermidine putrescine transport system, permease component I
GTH21_RS11310	COG3842	ATPase activity
GTH21_RS11315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTH21_RS11320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTH21_RS11325	COG1271	oxidase subunit
GTH21_RS11330	COG1294	oxidase, subunit
GTH21_RS11350	COG0826	peptidase U32
GTH21_RS11360	COG1396	sequence-specific DNA binding
GTH21_RS11365	COG3135	benzoate transporter
GTH21_RS11370	COG3708	Transcriptional regulator
GTH21_RS11370	COG2207	Transcriptional regulator
GTH21_RS11385	COG0500	methyltransferase
GTH21_RS11390	COG1275	C4-dicarboxylate transporter malic acid transport protein
GTH21_RS11395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTH21_RS11400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH21_RS11415	COG2272	Belongs to the type-B carboxylesterase lipase family
GTH21_RS11420	COG5383	Protein conserved in bacteria
GTH21_RS11425	COG3485	protocatechuate 3,4-dioxygenase
GTH21_RS11430	COG3485	protocatechuate 3,4-dioxygenase
GTH21_RS11435	COG0583	DNA-binding transcription factor activity
GTH21_RS11455	COG3038	cytochrome b561
GTH21_RS11475	COG2814	Major facilitator Superfamily
GTH21_RS11485	COG0673	inositol 2-dehydrogenase activity
GTH21_RS11495	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS11530	COG4659	FMN binding
GTH21_RS11540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTH21_RS11550	COG0625	glutathione transferase activity
GTH21_RS11555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GTH21_RS11570	COG3895	Periplasmic Protein
GTH21_RS11585	COG3706	GGDEF domain
GTH21_RS11600	COG1566	PFAM secretion protein HlyD family protein
GTH21_RS11605	COG1289	transmembrane transporter activity
GTH21_RS11610	COG2032	superoxide dismutase activity
GTH21_RS11615	COG4989	oxidoreductase activity
GTH21_RS11620	COG3313	Fe-S protein
GTH21_RS11625	COG1309	transcriptional regulator
GTH21_RS11630	COG1902	pentaerythritol trinitrate reductase activity
GTH21_RS11635	COG0346	lactoylglutathione lyase activity
GTH21_RS11645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GTH21_RS11650	COG0791	NLP P60 protein
GTH21_RS11665	COG2814	Major facilitator Superfamily
GTH21_RS11680	COG0583	DNA-binding transcription factor activity
GTH21_RS11685	COG2814	Major facilitator Superfamily
GTH21_RS11690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTH21_RS11695	COG0307	riboflavin synthase, alpha
GTH21_RS11755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GTH21_RS11795	COG1349	DNA-binding transcription factor activity
GTH21_RS11800	COG0346	lactoylglutathione lyase activity
GTH21_RS11825	COG0444	Belongs to the ABC transporter superfamily
GTH21_RS11830	COG4608	Belongs to the ABC transporter superfamily
GTH21_RS11860	COG0604	alcohol dehydrogenase
GTH21_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS11860	COG3321	synthase
GTH21_RS11900	COG0402	S-adenosylhomocysteine deaminase activity
GTH21_RS11925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTH21_RS11930	COG0277	FAD linked oxidase domain protein
GTH21_RS11955	COG0583	DNA-binding transcription factor activity
GTH21_RS11965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GTH21_RS11975	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTH21_RS11980	COG2610	gluconate transmembrane transporter activity
GTH21_RS11985	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS12020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH21_RS12035	COG0745	RESPONSE REGULATOR receiver
GTH21_RS12040	COG3850	Histidine kinase
GTH21_RS12040	COG5002	protein histidine kinase activity
GTH21_RS12055	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GTH21_RS12080	COG4235	cytochrome complex assembly
GTH21_RS12080	COG3088	subunit of a heme lyase
GTH21_RS12085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTH21_RS12090	COG1138	Cytochrome C-type biogenesis protein
GTH21_RS12105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTH21_RS12110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTH21_RS12115	COG4133	protoheme IX ABC transporter activity
GTH21_RS12145	COG1175	transmembrane transport
GTH21_RS12160	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GTH21_RS12165	COG3383	formate dehydrogenase (NAD+) activity
GTH21_RS12205	COG1126	abc transporter atp-binding protein
GTH21_RS12210	COG0765	amino acid transport
GTH21_RS12230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS12235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS12240	COG1120	ATPase activity
GTH21_RS12245	COG4774	siderophore transport
GTH21_RS12250	COG1116	anion transmembrane transporter activity
GTH21_RS12255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTH21_RS12275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTH21_RS12280	COG0583	DNA-binding transcription factor activity
GTH21_RS12300	COG2814	Major facilitator Superfamily
GTH21_RS12335	COG1414	Transcriptional regulator
GTH21_RS12360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GTH21_RS12365	COG2271	Major facilitator Superfamily
GTH21_RS12375	COG1309	transcriptional regulator
GTH21_RS12405	COG1376	ErfK ybiS ycfS ynhG family protein
GTH21_RS12420	COG0719	Fe-S assembly protein
GTH21_RS12425	COG0396	ATPase activity
GTH21_RS12430	COG0719	Fe-S assembly protein
GTH21_RS12435	COG0316	Belongs to the HesB IscA family
GTH21_RS12455	COG1309	transcriptional regulator
GTH21_RS12460	COG1304	FMN binding
GTH21_RS12485	COG0583	DNA-binding transcription factor activity
GTH21_RS12495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS12500	COG1120	ATPase activity
GTH21_RS12525	COG2261	transglycosylase associated protein
GTH21_RS12530	COG2050	protein possibly involved in aromatic compounds catabolism
GTH21_RS12535	COG0277	FAD linked oxidase domain protein
GTH21_RS12535	COG0247	lactate metabolic process
GTH21_RS12540	COG0628	permease
GTH21_RS12550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GTH21_RS12550	COG0574	Belongs to the PEP-utilizing enzyme family
GTH21_RS12565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTH21_RS12570	COG4256	Hemin uptake protein
GTH21_RS12580	COG0791	NLP P60 protein
GTH21_RS12590	COG0386	Belongs to the glutathione peroxidase family
GTH21_RS12610	COG0583	DNA-binding transcription factor activity
GTH21_RS12630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTH21_RS12630	COG0072	phenylalanine-tRNA ligase activity
GTH21_RS12670	COG3137	Salt-induced outer membrane protein
GTH21_RS12675	COG1105	Belongs to the carbohydrate kinase PfkB family
GTH21_RS12685	COG3001	Fructosamine kinase
GTH21_RS12695	COG2350	Protein conserved in bacteria
GTH21_RS12705	COG2353	YceI-like domain
GTH21_RS12730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTH21_RS12740	COG0444	Belongs to the ABC transporter superfamily
GTH21_RS12745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH21_RS12750	COG0601	transmembrane transport
GTH21_RS12755	COG4166	transmembrane transport
GTH21_RS12765	COG2095	MarC family integral membrane protein
GTH21_RS12775	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS12775	COG1454	alcohol dehydrogenase
GTH21_RS12780	COG1435	thymidine kinase activity
GTH21_RS12790	COG2916	Histone family protein nucleoid-structuring protein H-NS
GTH21_RS12795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTH21_RS12800	COG0745	RESPONSE REGULATOR receiver
GTH21_RS12805	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTH21_RS12815	COG0788	formyltetrahydrofolate deformylase activity
GTH21_RS12850	COG1522	sequence-specific DNA binding
GTH21_RS12860	COG2181	nitrate reductase activity
GTH21_RS12865	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GTH21_RS12870	COG1140	nitrate reductase beta subunit
GTH21_RS12875	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GTH21_RS12885	COG2223	nitrite transmembrane transporter activity
GTH21_RS12890	COG3850	Histidine kinase
GTH21_RS12895	COG2197	response regulator
GTH21_RS12900	COG4932	domain protein
GTH21_RS12905	COG0243	molybdopterin cofactor binding
GTH21_RS12910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GTH21_RS12910	COG2146	nitrite reductase [NAD(P)H] activity
GTH21_RS12915	COG1116	anion transmembrane transporter activity
GTH21_RS12925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTH21_RS12935	COG3707	response regulator
GTH21_RS12940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GTH21_RS12950	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GTH21_RS12955	COG4572	Cation transport regulator
GTH21_RS12960	COG0387	Pfam Sodium calcium exchanger
GTH21_RS12980	COG2890	protein-(glutamine-N5) methyltransferase activity
GTH21_RS13010	COG0659	secondary active sulfate transmembrane transporter activity
GTH21_RS13030	COG0012	GTP binding
GTH21_RS13115	COG1388	LysM domain
GTH21_RS13130	COG2885	chlorophyll binding
GTH21_RS13155	COG3122	Protein conserved in bacteria
GTH21_RS13170	COG0583	DNA-binding transcription factor activity
GTH21_RS13200	COG0583	DNA-binding transcription factor activity
GTH21_RS13235	COG1882	Formate acetyltransferase
GTH21_RS13250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GTH21_RS13255	COG0583	DNA-binding transcription factor activity
GTH21_RS13295	COG2308	Evidence 4 Homologs of previously reported genes of
GTH21_RS13310	COG4774	siderophore transport
GTH21_RS13320	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTH21_RS13345	COG2719	SpoVR family
GTH21_RS13375	COG0179	Fumarylacetoacetate (FAA) hydrolase
GTH21_RS13390	COG2894	cell division
GTH21_RS13400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GTH21_RS13410	COG3065	identical protein binding
GTH21_RS13420	COG1199	ATP-dependent helicase activity
GTH21_RS13425	COG0251	oxidation-reduction process
GTH21_RS13445	COG1760	l-serine dehydratase
GTH21_RS13455	COG2200	EAL domain
GTH21_RS13460	COG1253	flavin adenine dinucleotide binding
GTH21_RS13465	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS13465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS13470	COG3715	PTS system
GTH21_RS13475	COG3716	PTS system mannose fructose sorbose family IID component
GTH21_RS13490	COG2226	methyltransferase
GTH21_RS13495	COG0768	penicillin binding
GTH21_RS13530	COG1414	Transcriptional regulator
GTH21_RS13535	COG2814	Major facilitator Superfamily
GTH21_RS13555	COG1956	GAF domain-containing protein
GTH21_RS13560	COG2995	paraquat-inducible protein a
GTH21_RS13565	COG3008	intermembrane lipid transfer
GTH21_RS13590	COG2990	Protein conserved in bacteria
GTH21_RS13605	COG1276	copper resistance
GTH21_RS13610	COG2372	response to copper ion
GTH21_RS13620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTH21_RS13625	COG1770	oligopeptidase
GTH21_RS13630	COG2979	Protein of unknown function (DUF533)
GTH21_RS13635	COG3141	response to X-ray
GTH21_RS13645	COG0800	Aldolase
GTH21_RS13650	COG0129	dihydroxy-acid dehydratase activity
GTH21_RS13655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GTH21_RS13665	COG1737	Transcriptional regulator
GTH21_RS13675	COG1560	Kdo2-lipid A biosynthetic process
GTH21_RS13680	COG0739	heme binding
GTH21_RS13685	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GTH21_RS13695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTH21_RS13720	COG0494	nUDIX hydrolase
GTH21_RS13730	COG1335	isochorismatase
GTH21_RS13735	COG1801	Protein of unknown function DUF72
GTH21_RS13740	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GTH21_RS13760	COG3102	Protein conserved in bacteria
GTH21_RS13770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GTH21_RS13795	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS13805	COG1879	ABC-type sugar transport system periplasmic component
GTH21_RS13815	COG1528	Iron-storage protein
GTH21_RS13825	COG2211	Major facilitator Superfamily
GTH21_RS13835	COG0477	Major facilitator Superfamily
GTH21_RS13850	COG1528	Iron-storage protein
GTH21_RS13860	COG0814	amino acid
GTH21_RS13865	COG3318	Belongs to the UPF0149 family
GTH21_RS13865	COG3012	SEC-C Motif Domain Protein
GTH21_RS13900	COG2197	response regulator
GTH21_RS13910	COG2197	response regulator
GTH21_RS13935	COG0366	Alpha amylase catalytic
GTH21_RS13965	COG2354	Protein conserved in bacteria
GTH21_RS13970	COG0697	spore germination
GTH21_RS13975	COG3727	T/G mismatch-specific endonuclease activity
GTH21_RS13980	COG0270	DNA (cytosine-5-)-methyltransferase activity
GTH21_RS13985	COG1418	mRNA catabolic process
GTH21_RS14000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTH21_RS14055	COG0025	NhaP-type Na H and K H
GTH21_RS14060	COG1309	transcriptional regulator
GTH21_RS14065	COG0604	alcohol dehydrogenase
GTH21_RS14085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GTH21_RS14095	COG0534	Mate efflux family protein
GTH21_RS14120	COG3706	GGDEF domain
GTH21_RS14145	COG3615	Tellurite resistance protein tehB
GTH21_RS14155	COG3300	MHYT domain
GTH21_RS14155	COG5001	Diguanylate cyclase
GTH21_RS14165	COG0477	Major facilitator Superfamily
GTH21_RS14170	COG0095	Lipoate-protein ligase
GTH21_RS14175	COG0583	DNA-binding transcription factor activity
GTH21_RS14180	COG1942	4-Oxalocrotonate Tautomerase
GTH21_RS14190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GTH21_RS14210	COG1289	transmembrane transporter activity
GTH21_RS14225	COG2925	Exonuclease
GTH21_RS14230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTH21_RS14235	COG0640	Transcriptional regulator
GTH21_RS14240	COG0531	amino acid
GTH21_RS14250	COG0583	DNA-binding transcription factor activity
GTH21_RS14255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTH21_RS14285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GTH21_RS14310	COG0463	Glycosyl transferase, family 2
GTH21_RS14320	COG1216	Glycosyl transferase, family 2
GTH21_RS14320	COG1442	glycosyl transferase family 8
GTH21_RS14325	COG0438	transferase activity, transferring glycosyl groups
GTH21_RS14375	COG2244	polysaccharide biosynthetic process
GTH21_RS14405	COG1215	transferase activity, transferring glycosyl groups
GTH21_RS14415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTH21_RS14455	COG1253	flavin adenine dinucleotide binding
GTH21_RS14460	COG2982	Protein involved in outer membrane biogenesis
GTH21_RS14475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GTH21_RS14480	COG0443	Heat shock 70 kDa protein
GTH21_RS14485	COG5002	protein histidine kinase activity
GTH21_RS14505	COG1301	dicarboxylic acid transport
GTH21_RS14530	COG2205	protein histidine kinase activity
GTH21_RS14535	COG0745	RESPONSE REGULATOR receiver
GTH21_RS14550	COG4608	Belongs to the ABC transporter superfamily
GTH21_RS14555	COG0444	Belongs to the ABC transporter superfamily
GTH21_RS14565	COG0601	transmembrane transport
GTH21_RS14570	COG0747	negative chemotaxis
GTH21_RS14575	COG4948	Mandelate Racemase Muconate Lactonizing
GTH21_RS14580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH21_RS14590	COG1070	Carbohydrate kinase
GTH21_RS14625	COG1830	Aldolase
GTH21_RS14630	COG0351	phosphomethylpyrimidine kinase
GTH21_RS14645	COG0583	DNA-binding transcription factor activity
GTH21_RS14655	COG2252	PERMEase
GTH21_RS14660	COG0583	DNA-binding transcription factor activity
GTH21_RS14665	COG5455	response to cobalt ion
GTH21_RS14685	COG4807	Protein conserved in bacteria
GTH21_RS14695	COG3275	phosphorelay sensor kinase activity
GTH21_RS14705	COG1174	glycine betaine transport
GTH21_RS14710	COG1125	glycine betaine transport
GTH21_RS14715	COG1174	glycine betaine transport
GTH21_RS14720	COG1732	Glycine betaine
GTH21_RS14725	COG1472	Belongs to the glycosyl hydrolase 3 family
GTH21_RS14730	COG0277	FAD linked oxidase domain protein
GTH21_RS14740	COG1686	Belongs to the peptidase S11 family
GTH21_RS14750	COG0586	Pfam SNARE associated Golgi protein
GTH21_RS14755	COG1538	Outer membrane efflux protein
GTH21_RS14765	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS14780	COG3659	wide pore channel activity
GTH21_RS14785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTH21_RS14795	COG1346	cytolysis
GTH21_RS14805	COG2949	membrane
GTH21_RS14815	COG1129	ABC transporter
GTH21_RS14830	COG2311	Membrane
GTH21_RS14845	COG4771	TonB-dependent receptor
GTH21_RS14850	COG0833	amino acid
GTH21_RS14855	COG0583	DNA-binding transcription factor activity
GTH21_RS14860	COG2855	membrane
GTH21_RS14870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH21_RS14870	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GTH21_RS14870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH21_RS14875	COG1105	Belongs to the carbohydrate kinase PfkB family
GTH21_RS14880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS14880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS14900	COG1312	Catalyzes the dehydration of D-mannonate
GTH21_RS14905	COG0246	Mannitol dehydrogenase
GTH21_RS14910	COG0523	cobalamin synthesis protein
GTH21_RS14915	COG0671	phosphoesterase, PA-phosphatase related
GTH21_RS14920	COG0791	NLP P60 protein
GTH21_RS14925	COG2200	EAL domain
GTH21_RS14930	COG4166	transmembrane transport
GTH21_RS14935	COG4174	ABC transporter (Permease)
GTH21_RS14940	COG4239	(ABC) transporter, permease
GTH21_RS14945	COG4172	Belongs to the ABC transporter superfamily
GTH21_RS14955	COG2814	Major facilitator Superfamily
GTH21_RS14960	COG1187	pseudouridine synthase activity
GTH21_RS14965	COG1061	Type III restriction enzyme res subunit
GTH21_RS14985	COG0494	nUDIX hydrolase
GTH21_RS14990	COG1349	DNA-binding transcription factor activity
GTH21_RS15015	COG0628	permease
GTH21_RS15030	COG0659	secondary active sulfate transmembrane transporter activity
GTH21_RS15035	COG2239	Acts as a magnesium transporter
GTH21_RS15040	COG4615	Cyclic peptide transporter
GTH21_RS15045	COG3145	DNA-N1-methyladenine dioxygenase activity
GTH21_RS15050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTH21_RS15050	COG2169	Transcriptional regulator
GTH21_RS15065	COG2198	Histidine kinase
GTH21_RS15065	COG0642	Histidine kinase
GTH21_RS15075	COG0784	Response regulator, receiver
GTH21_RS15075	COG2205	protein histidine kinase activity
GTH21_RS15100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTH21_RS15105	COG0584	glycerophosphoryl diester phosphodiesterase
GTH21_RS15110	COG2271	Major facilitator Superfamily
GTH21_RS15115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTH21_RS15125	COG0247	lactate metabolic process
GTH21_RS15135	COG2271	Major facilitator Superfamily
GTH21_RS15155	COG1414	Transcriptional regulator
GTH21_RS15175	COG5464	transposase or invertase
GTH21_RS15185	COG0318	PFAM AMP-dependent synthetase and ligase
GTH21_RS15210	COG1169	isochorismate synthase
GTH21_RS15215	COG2153	protein acetylation
GTH21_RS15230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTH21_RS15235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTH21_RS15245	COG0839	Belongs to the complex I subunit 6 family
GTH21_RS15295	COG0583	DNA-binding transcription factor activity
GTH21_RS15300	COG0436	Aminotransferase
GTH21_RS15310	COG0490	domain, Protein
GTH21_RS15310	COG0471	metal ion transport
GTH21_RS15315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH21_RS15335	COG0280	phosphate acetyltransferase
GTH21_RS15335	COG0857	belongs to the CobB CobQ family
GTH21_RS15340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GTH21_RS15345	COG0622	Phosphoesterase
GTH21_RS15350	COG0625	glutathione transferase activity
GTH21_RS15355	COG0625	glutathione transferase activity
GTH21_RS15360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTH21_RS15365	COG1090	epimerase
GTH21_RS15380	COG4598	ABC transporter
GTH21_RS15385	COG4160	amino acid transport
GTH21_RS15410	COG0163	prenyltransferase activity
GTH21_RS15415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GTH21_RS15420	COG1286	toxin biosynthetic process
GTH21_RS15425	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GTH21_RS15430	COG0285	dihydrofolate synthase activity
GTH21_RS15440	COG0586	Pfam SNARE associated Golgi protein
GTH21_RS15450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTH21_RS15470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTH21_RS15485	COG3101	peptidyl-lysine hydroxylation
GTH21_RS15490	COG0730	response to heat
GTH21_RS15515	COG2062	phosphohistidine phosphatase, SixA
GTH21_RS15530	COG3691	Protein conserved in bacteria
GTH21_RS15540	COG2853	Lipoprotein
GTH21_RS15545	COG2116	formate transmembrane transporter activity
GTH21_RS15555	COG0582	viral genome integration into host DNA
GTH21_RS15615	COG0583	DNA-binding transcription factor activity
GTH21_RS15620	COG0590	tRNA wobble adenosine to inosine editing
GTH21_RS15625	COG2807	transmembrane transport
GTH21_RS15635	COG0436	Aminotransferase
GTH21_RS15650	COG3275	phosphorelay sensor kinase activity
GTH21_RS15655	COG3279	Response regulator of the LytR AlgR family
GTH21_RS15670	COG3961	Belongs to the TPP enzyme family
GTH21_RS15675	COG0667	Aldo Keto reductase
GTH21_RS15690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTH21_RS15695	COG2199	diguanylate cyclase activity
GTH21_RS15695	COG2200	EAL domain
GTH21_RS15710	COG3415	Transposase
GTH21_RS15715	COG3415	Transposase
GTH21_RS15745	COG0583	DNA-binding transcription factor activity
GTH21_RS15750	COG0385	Bile acid
GTH21_RS15755	COG3530	Putative quorum-sensing-regulated virulence factor
GTH21_RS15775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTH21_RS15815	COG4319	ketosteroid isomerase
GTH21_RS15825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GTH21_RS15830	COG4208	sulfate ABC transporter
GTH21_RS15835	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GTH21_RS15840	COG4150	thiosulfate binding
GTH21_RS15850	COG2837	iron assimilation
GTH21_RS15870	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTH21_RS15960	COG4810	utilization protein
GTH21_RS15970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GTH21_RS15975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTH21_RS15980	COG5342	invasion associated locus B
GTH21_RS15990	COG0493	'glutamate synthase
GTH21_RS15990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTH21_RS15995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH21_RS16005	COG1393	Belongs to the ArsC family
GTH21_RS16020	COG0400	carboxylic ester hydrolase activity
GTH21_RS16025	COG1444	tRNA N-acetyltransferase activity
GTH21_RS16030	COG2321	neutral zinc metallopeptidase
GTH21_RS16040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GTH21_RS16050	COG2716	regulation of RNA biosynthetic process
GTH21_RS16055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GTH21_RS16060	COG0628	permease
GTH21_RS16070	COG4783	chaperone-mediated protein folding
GTH21_RS16075	COG1393	Belongs to the ArsC family
GTH21_RS16090	COG2233	PERMEase
GTH21_RS16100	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS16115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GTH21_RS16130	COG2200	EAL domain
GTH21_RS16150	COG0641	radical SAM
GTH21_RS16155	COG3119	arylsulfatase activity
GTH21_RS16165	COG0516	GMP reductase activity
GTH21_RS16165	COG0517	IMP dehydrogenase activity
GTH21_RS16175	COG1645	bacterial-type flagellum-dependent swarming motility
GTH21_RS16195	COG2976	Protein conserved in bacteria
GTH21_RS16225	COG4953	penicillin-binding protein 1C
GTH21_RS16230	COG2373	Large extracellular alpha-helical protein
GTH21_RS16235	COG2897	thiosulfate sulfurtransferase activity
GTH21_RS16255	COG2975	iron-sulfur cluster assembly
GTH21_RS16260	COG0633	Ferredoxin
GTH21_RS16280	COG0822	iron-sulfur transferase activity
GTH21_RS16310	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GTH21_RS16315	COG3683	transport system, periplasmic component
GTH21_RS16320	COG3711	transcriptional antiterminator
GTH21_RS16325	COG2814	Major facilitator Superfamily
GTH21_RS16330	COG2017	converts alpha-aldose to the beta-anomer
GTH21_RS16335	COG2814	Major facilitator Superfamily
GTH21_RS16335	COG0477	Major facilitator Superfamily
GTH21_RS16340	COG0457	Tetratricopeptide repeat
GTH21_RS16345	COG1940	carbohydrate kinase activity
GTH21_RS16350	COG2259	Doxx family
GTH21_RS16360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTH21_RS16360	COG1017	nitric oxide dioxygenase activity
GTH21_RS16365	COG0347	Belongs to the P(II) protein family
GTH21_RS16370	COG2204	response regulator
GTH21_RS16375	COG3170	Tfp pilus assembly protein FimV
GTH21_RS16380	COG2205	protein histidine kinase activity
GTH21_RS16385	COG0047	phosphoribosylformylglycinamidine synthase activity
GTH21_RS16385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTH21_RS16400	COG0560	Phosphoserine phosphatase
GTH21_RS16405	COG1737	Transcriptional regulator
GTH21_RS16410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTH21_RS16420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GTH21_RS16440	COG0681	Belongs to the peptidase S26 family
GTH21_RS16450	COG3086	response to oxidative stress
GTH21_RS16455	COG3026	antisigma factor binding
GTH21_RS16460	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GTH21_RS16475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GTH21_RS16485	COG0513	Belongs to the DEAD box helicase family
GTH21_RS16500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTH21_RS16505	COG3118	belongs to the thioredoxin family
GTH21_RS16520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTH21_RS16525	COG5544	Lipoprotein
GTH21_RS16530	COG0477	Major facilitator Superfamily
GTH21_RS16555	COG0542	response to heat
GTH21_RS16570	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTH21_RS16575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTH21_RS16585	COG1605	Chorismate mutase
GTH21_RS16585	COG0077	Prephenate dehydratase
GTH21_RS16595	COG0287	Prephenate dehydrogenase
GTH21_RS16595	COG1605	Chorismate mutase
GTH21_RS16600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTH21_RS16610	COG2199	diguanylate cyclase activity
GTH21_RS16615	COG2885	chlorophyll binding
GTH21_RS16710	COG4695	Portal protein
GTH21_RS16865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTH21_RS16870	COG4137	Cytochrome C assembly protein
GTH21_RS16875	COG4536	flavin adenine dinucleotide binding
GTH21_RS16890	COG0497	DNA recombination
GTH21_RS16910	COG2867	negative regulation of translational initiation
GTH21_RS16940	COG2207	Transcriptional regulator
GTH21_RS16940	COG3708	Transcriptional regulator
GTH21_RS16945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS16980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS16990	COG0235	Class ii aldolase
GTH21_RS17000	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS17015	COG2197	response regulator
GTH21_RS17020	COG3539	Fimbrial protein
GTH21_RS17030	COG3188	usher protein
GTH21_RS17055	COG3539	Fimbrial protein
GTH21_RS17060	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS17065	COG3284	Transcriptional regulator
GTH21_RS17070	COG0583	DNA-binding transcription factor activity
GTH21_RS17080	COG0640	Transcriptional regulator
GTH21_RS17085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTH21_RS17100	COG2916	Histone family protein nucleoid-structuring protein H-NS
GTH21_RS17120	COG4575	ribosome binding
GTH21_RS17125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTH21_RS17130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTH21_RS17135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTH21_RS17145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTH21_RS17160	COG4176	ABC-type proline glycine betaine transport system permease component
GTH21_RS17170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GTH21_RS17185	COG1846	Transcriptional regulator
GTH21_RS17195	COG1566	PFAM secretion protein HlyD family protein
GTH21_RS17200	COG2814	Major facilitator Superfamily
GTH21_RS17205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GTH21_RS17225	COG1238	metal cluster binding
GTH21_RS17230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH21_RS17235	COG2823	Periplasmic or secreted lipoprotein
GTH21_RS17270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GTH21_RS17290	COG1546	Belongs to the CinA family
GTH21_RS17295	COG0803	Belongs to the bacterial solute-binding protein 9 family
GTH21_RS17300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTH21_RS17305	COG1121	(ABC) transporter
GTH21_RS17310	COG2951	lytic endotransglycosylase activity
GTH21_RS17315	COG3730	PTS system glucitol sorbitol-specific
GTH21_RS17320	COG3732	PTS system glucitol sorbitol-specific
GTH21_RS17330	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS17335	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS17340	COG1349	DNA-binding transcription factor activity
GTH21_RS17370	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GTH21_RS17375	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GTH21_RS17380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTH21_RS17385	COG1609	Transcriptional regulator
GTH21_RS17395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS17395	COG1263	PTS System
GTH21_RS17400	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS17410	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GTH21_RS17420	COG3260	NADH ubiquinone oxidoreductase 20
GTH21_RS17425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTH21_RS17430	COG3261	NADH dehydrogenase
GTH21_RS17430	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GTH21_RS17435	COG0650	Formate hydrogenlyase subunit 4
GTH21_RS17440	COG0651	ATP synthesis coupled electron transport
GTH21_RS17445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTH21_RS17460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GTH21_RS17465	COG0298	carbon dioxide binding
GTH21_RS17470	COG0409	Hydrogenase expression formation protein
GTH21_RS17475	COG0309	Hydrogenase expression formation protein (HypE)
GTH21_RS17485	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS17495	COG4580	involved in the transport of maltose and maltodextrins
GTH21_RS17500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS17505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS17510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS17515	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTH21_RS17520	COG1940	carbohydrate kinase activity
GTH21_RS17525	COG1609	Transcriptional regulator
GTH21_RS17530	COG0803	Belongs to the bacterial solute-binding protein 9 family
GTH21_RS17535	COG1121	(ABC) transporter
GTH21_RS17540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTH21_RS17545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTH21_RS17560	COG0679	Auxin Efflux Carrier
GTH21_RS17580	COG3720	iron ion transport
GTH21_RS17585	COG4558	Periplasmic binding protein
GTH21_RS17590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH21_RS17630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GTH21_RS17635	COG0163	prenyltransferase activity
GTH21_RS17660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTH21_RS17665	COG1388	LysM domain
GTH21_RS17665	COG4942	peptidase
GTH21_RS17725	COG2234	aminopeptidase activity
GTH21_RS17745	COG0720	synthase
GTH21_RS17750	COG0602	queuosine metabolic process
GTH21_RS17775	COG3956	TIGRFAM MazG family protein
GTH21_RS17780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTH21_RS17790	COG3850	Histidine kinase
GTH21_RS17790	COG3437	response regulator, receiver
GTH21_RS17790	COG4999	Histidine kinase
GTH21_RS17790	COG2205	protein histidine kinase activity
GTH21_RS17795	COG1929	Belongs to the glycerate kinase type-1 family
GTH21_RS17800	COG4948	Mandelate Racemase Muconate Lactonizing
GTH21_RS17805	COG4948	Mandelate Racemase Muconate Lactonizing
GTH21_RS17810	COG2271	Major facilitator Superfamily
GTH21_RS17815	COG0716	FMN binding
GTH21_RS17820	COG0564	pseudouridine synthase activity
GTH21_RS17825	COG3098	single-species biofilm formation
GTH21_RS17840	COG1611	Belongs to the LOG family
GTH21_RS17845	COG0814	amino acid
GTH21_RS17850	COG1760	l-serine dehydratase
GTH21_RS17855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTH21_RS17865	COG0477	Major facilitator Superfamily
GTH21_RS17870	COG1464	Belongs to the NlpA lipoprotein family
GTH21_RS17875	COG2011	ABC-type metal ion transport system permease component
GTH21_RS17880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTH21_RS17895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTH21_RS17915	COG1454	alcohol dehydrogenase
GTH21_RS17920	COG0235	Class ii aldolase
GTH21_RS17930	COG0738	Major facilitator superfamily
GTH21_RS17950	COG1349	DNA-binding transcription factor activity
GTH21_RS17960	COG2363	Small membrane protein
GTH21_RS17965	COG0583	DNA-binding transcription factor activity
GTH21_RS17975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTH21_RS17980	COG2166	iron-sulfur cluster assembly
GTH21_RS17985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GTH21_RS17990	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GTH21_RS18185	COG1454	alcohol dehydrogenase
GTH21_RS18185	COG1012	belongs to the aldehyde dehydrogenase family
GTH21_RS18190	COG4656	Part of a membrane complex involved in electron transport
GTH21_RS18220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GTH21_RS18225	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTH21_RS18230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GTH21_RS18230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GTH21_RS18240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTH21_RS18250	COG1025	Belongs to the peptidase M16 family
GTH21_RS18255	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GTH21_RS18260	COG4967	type IV pilus modification protein PilV
GTH21_RS18270	COG4795	General secretion pathway protein
GTH21_RS18275	COG2165	general secretion pathway protein
GTH21_RS18310	COG0861	Integral membrane protein TerC family
GTH21_RS18320	COG0667	Aldo Keto reductase
GTH21_RS18335	COG1609	Transcriptional regulator
GTH21_RS18345	COG2186	Transcriptional regulator
GTH21_RS18350	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS18355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS18360	COG1609	Transcriptional regulator
GTH21_RS18370	COG0583	DNA-binding transcription factor activity
GTH21_RS18375	COG1794	racemase activity, acting on amino acids and derivatives
GTH21_RS18380	COG1917	Cupin 2, conserved barrel domain protein
GTH21_RS18385	COG1175	transmembrane transport
GTH21_RS18390	COG0395	ABC-type sugar transport system, permease component
GTH21_RS18395	COG3842	ATPase activity
GTH21_RS18430	COG2814	Major facilitator Superfamily
GTH21_RS18435	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS18445	COG0823	Involved in the tonB-independent uptake of proteins
GTH21_RS18455	COG0183	Belongs to the thiolase family
GTH21_RS18470	COG0814	amino acid
GTH21_RS18475	COG0667	Aldo Keto reductase
GTH21_RS18525	COG0697	spore germination
GTH21_RS18530	COG1846	Transcriptional regulator
GTH21_RS18535	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GTH21_RS18540	COG0582	viral genome integration into host DNA
GTH21_RS18545	COG4974	Belongs to the 'phage' integrase family
GTH21_RS18560	COG3539	Fimbrial protein
GTH21_RS18565	COG3121	Chaperone
GTH21_RS18570	COG3188	usher protein
GTH21_RS18575	COG3539	Fimbrial protein
GTH21_RS18580	COG3539	Fimbrial protein
GTH21_RS18585	COG3539	Fimbrial protein
GTH21_RS18595	COG2388	GCN5-related N-acetyl-transferase
GTH21_RS18600	COG3592	Divergent 4Fe-4S mono-cluster
GTH21_RS18615	COG1289	transmembrane transporter activity
GTH21_RS18620	COG1538	Outer membrane efflux protein
GTH21_RS18630	COG3104	oligopeptide transport
GTH21_RS18635	COG1393	Belongs to the ArsC family
GTH21_RS18640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTH21_RS18675	COG0667	Aldo Keto reductase
GTH21_RS18690	COG2814	Major facilitator Superfamily
GTH21_RS18765	COG3561	AntA/AntB antirepressor
GTH21_RS18785	COG0582	viral genome integration into host DNA
GTH21_RS18795	COG4942	peptidase
GTH21_RS18820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTH21_RS18830	COG4974	Belongs to the 'phage' integrase family
GTH21_RS18835	COG0716	FMN binding
GTH21_RS18845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GTH21_RS18855	COG1272	protein, Hemolysin III
GTH21_RS18865	COG1737	Transcriptional regulator
GTH21_RS18870	COG2723	6-phospho-beta-galactosidase activity
GTH21_RS18890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTH21_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS18915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTH21_RS18920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTH21_RS18925	COG0006	proline dipeptidase activity
GTH21_RS18945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTH21_RS18950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTH21_RS18970	COG2968	Membrane
GTH21_RS18980	COG0668	transmembrane transport
GTH21_RS18985	COG0191	fructose-bisphosphate aldolase activity
GTH21_RS19000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTH21_RS19005	COG0501	Belongs to the peptidase M48B family
GTH21_RS19025	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
GTH21_RS19030	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS19060	COG1414	Transcriptional regulator
GTH21_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS19080	COG2146	nitrite reductase [NAD(P)H] activity
GTH21_RS19115	COG2814	Major facilitator Superfamily
GTH21_RS19125	COG2356	endonuclease I
GTH21_RS19130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GTH21_RS19135	COG0189	ligase activity
GTH21_RS19160	COG2805	Type II/IV secretion system protein
GTH21_RS19170	COG0762	integral membrane protein
GTH21_RS19185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTH21_RS19195	COG3171	Protein conserved in bacteria
GTH21_RS19205	COG1194	a g-specific adenine glycosylase
GTH21_RS19220	COG2211	Major facilitator Superfamily
GTH21_RS19225	COG1982	Orn Lys Arg decarboxylase major
GTH21_RS19230	COG1811	Na channel or pump
GTH21_RS19240	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GTH21_RS19295	COG3423	Transcriptional regulator
GTH21_RS19300	COG1278	Cold shock
GTH21_RS19310	COG3423	Transcriptional regulator
GTH21_RS19590	COG0626	cystathionine gamma-synthase activity
GTH21_RS19595	COG0583	DNA-binding transcription factor activity
GTH21_RS19615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTH21_RS19620	COG0754	glutathionylspermidine amidase activity
GTH21_RS19635	COG0625	glutathione transferase activity
GTH21_RS19660	COG2211	Major facilitator Superfamily
GTH21_RS19665	COG0848	biopolymer transport protein
GTH21_RS19675	COG0626	cystathionine gamma-synthase activity
GTH21_RS19680	COG0586	Pfam SNARE associated Golgi protein
GTH21_RS19685	COG2207	Transcriptional regulator
GTH21_RS19690	COG1979	alcohol dehydrogenase
GTH21_RS19695	COG0656	L-ascorbic acid biosynthetic process
GTH21_RS19705	COG1032	radical SAM domain protein
GTH21_RS19710	COG2132	Multicopper oxidase
GTH21_RS19715	COG0204	Acyl-transferase
GTH21_RS19720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTH21_RS19725	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GTH21_RS19730	COG3111	PFAM Bacterial OB fold (BOF) protein
GTH21_RS19740	COG0642	Histidine kinase
GTH21_RS19745	COG2249	NAD(P)H dehydrogenase (quinone) activity
GTH21_RS19750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GTH21_RS19760	COG3150	esterase
GTH21_RS19765	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GTH21_RS19770	COG3151	Protein conserved in bacteria
GTH21_RS19775	COG0494	nUDIX hydrolase
GTH21_RS19790	COG0754	glutathionylspermidine amidase activity
GTH21_RS19795	COG3384	dioxygenase
GTH21_RS19810	COG2960	long-chain fatty acid transporting porin activity
GTH21_RS19835	COG3025	triphosphatase activity
GTH21_RS19840	COG4991	sh3 domain protein
GTH21_RS19855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTH21_RS19920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTH21_RS19925	COG0358	DNA primase activity
GTH21_RS19930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTH21_RS19975	COG2003	Belongs to the UPF0758 family
GTH21_RS19990	COG3468	outer membrane autotransporter barrel domain protein
GTH21_RS20020	COG1002	Type II restriction enzyme, methylase subunits
GTH21_RS20025	COG1061	Type III restriction enzyme res subunit
GTH21_RS20030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTH21_RS20085	COG0482	sulfurtransferase activity
GTH21_RS20105	COG3173	Aminoglycoside phosphotransferase
GTH21_RS20155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GTH21_RS20195	COG2197	response regulator
GTH21_RS20200	COG2198	Histidine kinase
GTH21_RS20200	COG2205	protein histidine kinase activity
GTH21_RS20200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS20200	COG0784	Response regulator, receiver
GTH21_RS20210	COG3247	response to pH
GTH21_RS20280	COG2376	Dihydroxyacetone kinase
GTH21_RS20285	COG1461	Dihydroxyacetone kinase
GTH21_RS20300	COG2375	cellular response to nickel ion
GTH21_RS20310	COG1695	Transcriptional regulator
GTH21_RS20360	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTH21_RS20360	COG1902	pentaerythritol trinitrate reductase activity
GTH21_RS20380	COG1451	nucleotide metabolic process
GTH21_RS20385	COG0673	inositol 2-dehydrogenase activity
GTH21_RS20390	COG0861	Integral membrane protein TerC family
GTH21_RS20405	COG2721	sulfolactate sulfo-lyase activity
GTH21_RS20415	COG2271	Major facilitator Superfamily
GTH21_RS20420	COG2186	Transcriptional regulator
GTH21_RS20425	COG0586	Pfam SNARE associated Golgi protein
GTH21_RS20435	COG1422	Protein of unknown function (DUF1090)
GTH21_RS20440	COG4575	ribosome binding
GTH21_RS20445	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
GTH21_RS20455	COG2259	Doxx family
GTH21_RS20460	COG0435	Glutathione S-transferase
GTH21_RS20465	COG3152	Membrane
GTH21_RS20470	COG0583	DNA-binding transcription factor activity
GTH21_RS20475	COG1741	Belongs to the pirin family
GTH21_RS20505	COG1929	Belongs to the glycerate kinase type-1 family
GTH21_RS20510	COG2084	Dehydrogenase
GTH21_RS20520	COG2271	Major facilitator Superfamily
GTH21_RS20530	COG2721	sulfolactate sulfo-lyase activity
GTH21_RS20535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS20540	COG1349	DNA-binding transcription factor activity
GTH21_RS20555	COG1105	Belongs to the carbohydrate kinase PfkB family
GTH21_RS20560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH21_RS20560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH21_RS20560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS20565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS20565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS20575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS20580	COG3414	Phosphotransferase system galactitol-specific IIB component
GTH21_RS20585	COG3775	system Galactitol-specific IIC component
GTH21_RS20590	COG1063	alcohol dehydrogenase
GTH21_RS20605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GTH21_RS20625	COG2823	Periplasmic or secreted lipoprotein
GTH21_RS20630	COG0701	Predicted permease
GTH21_RS20635	COG0702	epimerase
GTH21_RS20640	COG0693	protein deglycase activity
GTH21_RS20655	COG3153	acetyltransferase
GTH21_RS20660	COG3154	lipid carrier protein
GTH21_RS20665	COG0826	peptidase U32
GTH21_RS20670	COG0826	peptidase U32
GTH21_RS20675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTH21_RS20720	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GTH21_RS20745	COG0814	amino acid
GTH21_RS20790	COG0195	Participates in both transcription termination and antitermination
GTH21_RS20835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTH21_RS20845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GTH21_RS20850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GTH21_RS20860	COG1534	Rna-binding protein
GTH21_RS20870	COG2027	D-alanyl-D-alanine carboxypeptidase
GTH21_RS20880	COG0697	spore germination
GTH21_RS20895	COG0142	geranyltranstransferase activity
GTH21_RS20900	COG3423	Transcriptional regulator
GTH21_RS20910	COG5007	Belongs to the BolA IbaG family
GTH21_RS20915	COG3113	response to antibiotic
GTH21_RS20920	COG2854	intermembrane phospholipid transfer
GTH21_RS20925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTH21_RS20930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GTH21_RS20935	COG1127	ABC transporter
GTH21_RS20940	COG0530	calcium, potassium:sodium antiporter activity
GTH21_RS20950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GTH21_RS20955	COG3117	lipopolysaccharide transmembrane transporter activity
GTH21_RS20960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GTH21_RS20965	COG1137	ATPase activity
GTH21_RS20970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GTH21_RS20975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTH21_RS20980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS20990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS20995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTH21_RS21000	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GTH21_RS21005	COG0784	Response regulator, receiver
GTH21_RS21005	COG2198	Histidine kinase
GTH21_RS21005	COG5002	protein histidine kinase activity
GTH21_RS21010	COG1312	Catalyzes the dehydration of D-mannonate
GTH21_RS21020	COG1063	alcohol dehydrogenase
GTH21_RS21025	COG2271	Major facilitator Superfamily
GTH21_RS21030	COG1242	4 iron, 4 sulfur cluster binding
GTH21_RS21035	COG0067	glutamate synthase
GTH21_RS21035	COG0069	glutamate synthase activity
GTH21_RS21035	COG0070	glutamate synthase
GTH21_RS21040	COG0493	'glutamate synthase
GTH21_RS21050	COG2969	positive regulation of protein catabolic process
GTH21_RS21055	COG0625	glutathione transferase activity
GTH21_RS21075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GTH21_RS21080	COG3105	Protein conserved in bacteria
GTH21_RS21085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTH21_RS21090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTH21_RS21115	COG2732	(Barnase) inhibitor
GTH21_RS21120	COG1289	transmembrane transporter activity
GTH21_RS21135	COG0583	DNA-binding transcription factor activity
GTH21_RS21140	COG0312	modulator of DNA gyrase
GTH21_RS21145	COG3164	Protein of unknown function
GTH21_RS21150	COG1530	ribonuclease E activity
GTH21_RS21160	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GTH21_RS21165	COG1792	Involved in formation and maintenance of cell shape
GTH21_RS21170	COG1077	Cell shape determining protein MreB Mrl
GTH21_RS21175	COG2200	EAL domain
GTH21_RS21175	COG2199	diguanylate cyclase activity
GTH21_RS21200	COG0511	ligase activity, forming carbon-carbon bonds
GTH21_RS21205	COG0439	Biotin carboxylase
GTH21_RS21210	COG3924	membrane
GTH21_RS21215	COG4145	pantothenate transmembrane transporter activity
GTH21_RS21235	COG1309	transcriptional regulator
GTH21_RS21240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS21245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH21_RS21280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTH21_RS21300	COG0551	DNA topoisomerase type I activity
GTH21_RS21310	COG0758	DNA mediated transformation
GTH21_RS21340	COG3036	rescue of stalled ribosome
GTH21_RS21345	COG0789	Transcriptional regulator
GTH21_RS21360	COG0202	RNA polymerase activity
GTH21_RS21385	COG0201	protein transport
GTH21_RS21450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTH21_RS21465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GTH21_RS21490	COG0051	transcription antitermination factor activity, RNA binding
GTH21_RS21550	COG2964	Protein conserved in bacteria
GTH21_RS21555	COG0545	Peptidyl-prolyl cis-trans isomerase
GTH21_RS21565	COG1047	Peptidyl-prolyl cis-trans
GTH21_RS21570	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GTH21_RS21585	COG0488	(ABC) transporter
GTH21_RS21595	COG0429	hydrolase of the alpha beta-hydrolase fold
GTH21_RS21605	COG3954	Phosphoribulokinase
GTH21_RS21610	COG1765	OsmC-like protein
GTH21_RS21620	COG1289	transmembrane transporter activity
GTH21_RS21625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTH21_RS21650	COG0738	Major facilitator superfamily
GTH21_RS21655	COG0402	S-adenosylhomocysteine deaminase activity
GTH21_RS21665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GTH21_RS21690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTH21_RS21695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GTH21_RS21700	COG3266	domain, Protein
GTH21_RS21715	COG4796	Type ii and iii secretion system protein
GTH21_RS21740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GTH21_RS21745	COG0494	nUDIX hydrolase
GTH21_RS21755	COG1011	Hydrolase
GTH21_RS21760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTH21_RS21780	COG0745	RESPONSE REGULATOR receiver
GTH21_RS21785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTH21_RS21790	COG2183	response to ionizing radiation
GTH21_RS21795	COG1918	ferrous iron import across plasma membrane
GTH21_RS21820	COG1040	competence protein
GTH21_RS21830	COG2610	gluconate transmembrane transporter activity
GTH21_RS21835	COG1640	4-alpha-glucanotransferase
GTH21_RS21840	COG0058	SHG alpha-glucan phosphorylase activity
GTH21_RS21850	COG1349	DNA-binding transcription factor activity
GTH21_RS21865	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTH21_RS21880	COG0058	SHG alpha-glucan phosphorylase activity
GTH21_RS21905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTH21_RS21915	COG2610	gluconate transmembrane transporter activity
GTH21_RS21920	COG3265	gluconokinase activity
GTH21_RS21925	COG1609	Transcriptional regulator
GTH21_RS21930	COG1741	Belongs to the pirin family
GTH21_RS21935	COG0673	inositol 2-dehydrogenase activity
GTH21_RS21945	COG1247	-acetyltransferase
GTH21_RS21950	COG0405	Gamma-glutamyltransferase
GTH21_RS21960	COG0584	glycerophosphoryl diester phosphodiesterase
GTH21_RS22010	COG0559	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS22015	COG0683	leucine binding
GTH21_RS22025	COG0683	leucine binding
GTH21_RS22035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTH21_RS22050	COG2177	Part of the ABC transporter FtsEX involved in
GTH21_RS22055	COG2884	Cell division ATP-binding protein ftsE
GTH21_RS22060	COG0552	protein localization to endoplasmic reticulum
GTH21_RS22065	COG0742	ribosomal rna small subunit methyltransferase
GTH21_RS22070	COG3776	membrane
GTH21_RS22080	COG3714	YhhN family
GTH21_RS22095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GTH21_RS22105	COG0477	Major facilitator Superfamily
GTH21_RS22110	COG0628	permease
GTH21_RS22150	COG3479	Phenolic acid decarboxylase
GTH21_RS22160	COG0747	negative chemotaxis
GTH21_RS22165	COG0601	transmembrane transport
GTH21_RS22170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH21_RS22180	COG1124	(ABC) transporter
GTH21_RS22190	COG2239	Acts as a magnesium transporter
GTH21_RS22195	COG2081	HI0933 family
GTH21_RS22200	COG0306	phosphate transporter
GTH21_RS22210	COG0589	response to stress
GTH21_RS22230	COG0671	phosphoesterase, PA-phosphatase related
GTH21_RS22235	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GTH21_RS22240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTH21_RS22250	COG1454	alcohol dehydrogenase
GTH21_RS22260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH21_RS22265	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS22270	COG0583	DNA-binding transcription factor activity
GTH21_RS22275	COG1295	ribonuclease BN
GTH21_RS22280	COG0477	Major facilitator Superfamily
GTH21_RS22285	COG2982	Protein involved in outer membrane biogenesis
GTH21_RS22300	COG0612	Peptidase, M16
GTH21_RS22310	COG2200	EAL domain
GTH21_RS22310	COG2199	diguanylate cyclase activity
GTH21_RS22315	COG0457	Tetratricopeptide repeat
GTH21_RS22315	COG3118	belongs to the thioredoxin family
GTH21_RS22320	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GTH21_RS22325	COG1215	transferase activity, transferring glycosyl groups
GTH21_RS22355	COG2194	sulfuric ester hydrolase activity
GTH21_RS22370	COG0457	Tetratricopeptide repeat
GTH21_RS22375	COG1215	transferase activity, transferring glycosyl groups
GTH21_RS22385	COG2894	cell division
GTH21_RS22400	COG4608	Belongs to the ABC transporter superfamily
GTH21_RS22405	COG0444	Belongs to the ABC transporter superfamily
GTH21_RS22410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH21_RS22415	COG0601	transmembrane transport
GTH21_RS22420	COG0747	negative chemotaxis
GTH21_RS22455	COG2223	nitrite transmembrane transporter activity
GTH21_RS22460	COG5571	outer membrane autotransporter
GTH21_RS22465	COG2818	Glycosylase
GTH21_RS22470	COG0456	acetyltransferase
GTH21_RS22475	COG0243	molybdopterin cofactor binding
GTH21_RS22480	COG2885	chlorophyll binding
GTH21_RS22490	COG1609	Transcriptional regulator
GTH21_RS22500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS22520	COG2814	Major facilitator Superfamily
GTH21_RS22525	COG2944	sequence-specific DNA binding
GTH21_RS22530	COG1278	Cold shock
GTH21_RS22565	COG3274	enterobacterial common antigen metabolic process
GTH21_RS22570	COG4682	membrane
GTH21_RS22575	COG4682	membrane
GTH21_RS22590	COG4213	ABC transporter substrate-binding protein
GTH21_RS22600	COG4214	carbohydrate transport
GTH21_RS22605	COG2207	Transcriptional regulator
GTH21_RS22605	COG1609	Transcriptional regulator
GTH21_RS22610	COG2992	FlgJ-related protein
GTH21_RS22615	COG0366	Alpha amylase catalytic
GTH21_RS22620	COG3977	Valine--pyruvate aminotransferase
GTH21_RS22625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTH21_RS22630	COG1414	Transcriptional regulator
GTH21_RS22635	COG3276	selenocysteine insertion sequence binding
GTH21_RS22645	COG0625	glutathione transferase activity
GTH21_RS22665	COG3722	fumarate hydratase activity
GTH21_RS22685	COG2186	Transcriptional regulator
GTH21_RS22695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GTH21_RS22720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTH21_RS22725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTH21_RS22735	COG4942	peptidase
GTH21_RS22740	COG2861	carbohydrate metabolic process
GTH21_RS22745	COG0463	Glycosyl transferase, family 2
GTH21_RS22755	COG0156	8-amino-7-oxononanoate synthase activity
GTH21_RS22770	COG0859	PFAM glycosyl transferase family 9
GTH21_RS22775	COG0438	transferase activity, transferring glycosyl groups
GTH21_RS22780	COG3307	-O-antigen
GTH21_RS22785	COG1442	glycosyl transferase family 8
GTH21_RS22785	COG1216	Glycosyl transferase, family 2
GTH21_RS22795	COG0859	PFAM glycosyl transferase family 9
GTH21_RS22805	COG0438	transferase activity, transferring glycosyl groups
GTH21_RS22810	COG1216	Glycosyl transferase, family 2
GTH21_RS22815	COG1519	Transferase
GTH21_RS22850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTH21_RS22875	COG0842	Transport permease protein
GTH21_RS22880	COG1131	(ABC) transporter
GTH21_RS22905	COG1561	YicC-like family, N-terminal region
GTH21_RS22915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GTH21_RS22920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTH21_RS22920	COG2169	Transcriptional regulator
GTH21_RS22930	COG2860	membrane
GTH21_RS22950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTH21_RS22955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTH21_RS22960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTH21_RS22965	COG1494	fructose-1,6-bisphosphatase
GTH21_RS22975	COG3152	Membrane
GTH21_RS23000	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GTH21_RS23020	COG0786	glutamate:sodium symporter activity
GTH21_RS23025	COG2233	PERMEase
GTH21_RS23030	COG2982	Protein involved in outer membrane biogenesis
GTH21_RS23035	COG1263	PTS System
GTH21_RS23035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS23040	COG1486	melibiose metabolic process
GTH21_RS23050	COG1501	Belongs to the glycosyl hydrolase 31 family
GTH21_RS23055	COG2211	Major facilitator Superfamily
GTH21_RS23115	COG1064	alcohol dehydrogenase
GTH21_RS23125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GTH21_RS23140	COG1464	Belongs to the NlpA lipoprotein family
GTH21_RS23165	COG0583	DNA-binding transcription factor activity
GTH21_RS23200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH21_RS23210	COG2814	Major facilitator Superfamily
GTH21_RS23220	COG1263	PTS System
GTH21_RS23220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS23225	COG0697	spore germination
GTH21_RS23240	COG2828	Protein conserved in bacteria
GTH21_RS23245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTH21_RS23250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GTH21_RS23255	COG0583	DNA-binding transcription factor activity
GTH21_RS23260	COG3384	dioxygenase
GTH21_RS23270	COG1609	Transcriptional regulator
GTH21_RS23280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS23280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS23285	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTH21_RS23290	COG4580	involved in the transport of maltose and maltodextrins
GTH21_RS23315	COG2188	Transcriptional regulator
GTH21_RS23355	COG2271	Major facilitator Superfamily
GTH21_RS23365	COG2197	response regulator
GTH21_RS23370	COG0440	acetolactate synthase activity
GTH21_RS23375	COG0028	Belongs to the TPP enzyme family
GTH21_RS23405	COG2814	Major facilitator Superfamily
GTH21_RS23410	COG0583	DNA-binding transcription factor activity
GTH21_RS23420	COG2610	gluconate transmembrane transporter activity
GTH21_RS23440	COG2149	membrane
GTH21_RS23455	COG2188	Transcriptional regulator
GTH21_RS23480	COG5645	(Lipo)protein
GTH21_RS23485	COG0823	Involved in the tonB-independent uptake of proteins
GTH21_RS23490	COG2271	Major facilitator Superfamily
GTH21_RS23500	COG0800	Aldolase
GTH21_RS23505	COG3734	2-keto-3-deoxy-galactonokinase
GTH21_RS23510	COG2186	Transcriptional regulator
GTH21_RS23525	COG0561	phosphatase activity
GTH21_RS23530	COG0187	DNA topoisomerase II activity
GTH21_RS23560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GTH21_RS23590	COG2091	lysine biosynthetic process via aminoadipic acid
GTH21_RS23595	COG0431	NADPH-dependent FMN reductase
GTH21_RS23600	COG2252	PERMEase
GTH21_RS23610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH21_RS23615	COG0363	glucosamine-6-phosphate deaminase activity
GTH21_RS23620	COG2382	esterase
GTH21_RS23635	COG0704	Plays a role in the regulation of phosphate uptake
GTH21_RS23640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTH21_RS23645	COG0581	inorganic phosphate transmembrane transporter activity
GTH21_RS23650	COG0573	inorganic phosphate transmembrane transporter activity
GTH21_RS23655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTH21_RS23660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTH21_RS23725	COG3312	ion transport
GTH21_RS23740	COG0716	FMN binding
GTH21_RS23745	COG1522	sequence-specific DNA binding
GTH21_RS23775	COG1129	ABC transporter
GTH21_RS23780	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS23790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS23795	COG1609	Transcriptional regulator
GTH21_RS23800	COG0477	Major facilitator Superfamily
GTH21_RS23805	COG2186	Transcriptional regulator
GTH21_RS23830	COG1763	Mo-molybdopterin cofactor biosynthetic process
GTH21_RS23840	COG3084	Protein conserved in bacteria
GTH21_RS23845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTH21_RS23855	COG0204	Acyl-transferase
GTH21_RS23875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTH21_RS23890	COG3852	Histidine kinase
GTH21_RS23905	COG1011	Hydrolase
GTH21_RS23920	COG0456	acetyltransferase
GTH21_RS23930	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GTH21_RS23945	COG2864	formate dehydrogenase
GTH21_RS23950	COG0437	4 iron, 4 sulfur cluster binding
GTH21_RS23970	COG0205	6-phosphofructokinase activity
GTH21_RS24030	COG2211	Major facilitator Superfamily
GTH21_RS24040	COG1454	alcohol dehydrogenase
GTH21_RS24045	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS24050	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS24055	COG1129	ABC transporter
GTH21_RS24095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GTH21_RS24100	COG2258	MOSC domain
GTH21_RS24105	COG2205	protein histidine kinase activity
GTH21_RS24110	COG0745	RESPONSE REGULATOR receiver
GTH21_RS24115	COG3678	ATP-independent chaperone mediated protein folding
GTH21_RS24135	COG1575	Belongs to the MenA family. Type 1 subfamily
GTH21_RS24150	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTH21_RS24155	COG1609	Transcriptional regulator
GTH21_RS24160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTH21_RS24175	COG0626	cystathionine gamma-synthase activity
GTH21_RS24180	COG0527	aspartate kinase activity
GTH21_RS24180	COG0460	homoserine dehydrogenase
GTH21_RS24190	COG0737	Belongs to the 5'-nucleotidase family
GTH21_RS24200	COG0583	DNA-binding transcription factor activity
GTH21_RS24210	COG0697	spore germination
GTH21_RS24215	COG0371	Dehydrogenase
GTH21_RS24225	COG2207	Transcriptional regulator
GTH21_RS24230	COG3443	Belongs to the bacterial solute-binding protein 9 family
GTH21_RS24245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GTH21_RS24260	COG0583	DNA-binding transcription factor activity
GTH21_RS24335	COG3085	chromosome segregation
GTH21_RS24355	COG3978	acetolactate synthase activity
GTH21_RS24370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GTH21_RS24375	COG0583	DNA-binding transcription factor activity
GTH21_RS24385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTH21_RS24390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTH21_RS24400	COG1811	Na channel or pump
GTH21_RS24425	COG3118	belongs to the thioredoxin family
GTH21_RS24430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GTH21_RS24435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTH21_RS24445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTH21_RS24450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GTH21_RS24455	COG1088	dTDP-glucose 4,6-dehydratase activity
GTH21_RS24460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GTH21_RS24465	COG0456	acetyltransferase
GTH21_RS24470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GTH21_RS24475	COG2244	polysaccharide biosynthetic process
GTH21_RS24525	COG3071	HemY protein
GTH21_RS24530	COG2959	enzyme of heme biosynthesis
GTH21_RS24545	COG3072	Adenylate cyclase
GTH21_RS24575	COG1011	Hydrolase
GTH21_RS24580	COG0210	DNA helicase
GTH21_RS24610	COG1280	lysine exporter protein (LysE YggA)
GTH21_RS24620	COG1280	lysine exporter protein (LysE YggA)
GTH21_RS24625	COG2267	carboxylic ester hydrolase activity
GTH21_RS24630	COG0561	phosphatase activity
GTH21_RS24635	COG0697	spore germination
GTH21_RS24640	COG0583	DNA-binding transcription factor activity
GTH21_RS24670	COG3165	ubiquinone biosynthetic process from chorismate
GTH21_RS24690	COG0805	protein transport
GTH21_RS24735	COG1739	Uncharacterized protein family UPF0029
GTH21_RS24745	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GTH21_RS24775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTH21_RS24820	COG0250	Participates in transcription elongation, termination and antitermination
GTH21_RS24855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTH21_RS24860	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTH21_RS24870	COG3706	GGDEF domain
GTH21_RS24885	COG2104	thiamine diphosphate biosynthetic process
GTH21_RS24890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTH21_RS24905	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GTH21_RS24940	COG3678	ATP-independent chaperone mediated protein folding
GTH21_RS24945	COG4191	Histidine kinase
GTH21_RS24955	COG0151	Belongs to the GarS family
GTH21_RS24985	COG0456	acetyltransferase
GTH21_RS24995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GTH21_RS25045	COG0527	aspartate kinase activity
GTH21_RS25055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTH21_RS25065	COG0251	oxidation-reduction process
GTH21_RS25110	COG4580	involved in the transport of maltose and maltodextrins
GTH21_RS25135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GTH21_RS25145	COG0534	Mate efflux family protein
GTH21_RS25155	COG3237	CsbD-like
GTH21_RS25160	COG0735	belongs to the Fur family
GTH21_RS25170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTH21_RS25185	COG0305	Participates in initiation and elongation during chromosome replication
GTH21_RS25190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTH21_RS25205	COG0432	Pfam Uncharacterised protein family UPF0047
GTH21_RS25210	COG2315	Protein conserved in bacteria
GTH21_RS25225	COG0741	lytic transglycosylase activity
GTH21_RS25235	COG4771	TonB-dependent receptor
GTH21_RS25260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTH21_RS25270	COG0483	inositol monophosphate 1-phosphatase activity
GTH21_RS25275	COG1609	Transcriptional regulator
GTH21_RS25280	COG1234	tRNA 3'-trailer cleavage
GTH21_RS25310	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GTH21_RS25320	COG0789	Transcriptional regulator
GTH21_RS25325	COG0625	glutathione transferase activity
GTH21_RS25330	COG2252	PERMEase
GTH21_RS25335	COG0025	NhaP-type Na H and K H
GTH21_RS25340	COG0583	DNA-binding transcription factor activity
GTH21_RS25345	COG1380	Effector of murein hydrolase LrgA
GTH21_RS25350	COG1346	cytolysis
GTH21_RS25360	COG3539	Fimbrial protein
GTH21_RS25390	COG3162	membrane
GTH21_RS25395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTH21_RS25405	COG1301	dicarboxylic acid transport
GTH21_RS25410	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GTH21_RS25445	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS25450	COG1129	ABC transporter
GTH21_RS25455	COG4191	Histidine kinase
GTH21_RS25455	COG0784	Response regulator, receiver
GTH21_RS25465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GTH21_RS25475	COG3454	Phosphonate metabolism
GTH21_RS25480	COG4778	phosphonate C-P lyase system protein PhnL
GTH21_RS25485	COG4107	phosphonate C-P lyase system protein PhnK
GTH21_RS25490	COG3627	carbon phosphorus lyase activity
GTH21_RS25495	COG3626	phosphonate metabolism
GTH21_RS25500	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GTH21_RS25505	COG3624	Phosphonate C-P lyase system protein PhnG
GTH21_RS25510	COG2188	Transcriptional regulator
GTH21_RS25515	COG2764	glyoxalase bleomycin resistance protein dioxygenase
GTH21_RS25520	COG2824	Alkylphosphonate utilization operon protein PhnA
GTH21_RS25530	COG2169	Transcriptional regulator
GTH21_RS25535	COG1486	melibiose metabolic process
GTH21_RS25580	COG0861	Integral membrane protein TerC family
GTH21_RS25600	COG1215	transferase activity, transferring glycosyl groups
GTH21_RS25605	COG1649	PFAM Uncharacterised BCR, COG1649
GTH21_RS25605	COG0726	polysaccharide deacetylase
GTH21_RS25610	COG0457	Tetratricopeptide repeat
GTH21_RS25660	COG1309	transcriptional regulator
GTH21_RS25675	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTH21_RS25680	COG1027	Aspartate ammonia-lyase
GTH21_RS25685	COG3030	protein affecting phage T7 exclusion by the F plasmid
GTH21_RS25690	COG0531	amino acid
GTH21_RS25710	COG3539	Fimbrial protein
GTH21_RS25715	COG3188	usher protein
GTH21_RS25750	COG0745	RESPONSE REGULATOR receiver
GTH21_RS25755	COG1509	lysine 2,3-aminomutase activity
GTH21_RS25770	COG5510	response to toxic substance
GTH21_RS25775	COG2076	Multidrug Resistance protein
GTH21_RS25795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GTH21_RS25800	COG1053	succinate dehydrogenase
GTH21_RS25815	COG3264	Mechanosensitive ion channel
GTH21_RS25815	COG1511	domain protein
GTH21_RS25835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH21_RS25855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GTH21_RS25860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTH21_RS25860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GTH21_RS25865	COG0802	atpase or kinase
GTH21_RS25870	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTH21_RS25895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTH21_RS25900	COG0330	HflC and HflK could
GTH21_RS25905	COG0330	HflC and HflK could
GTH21_RS25915	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GTH21_RS25930	COG0557	exoribonuclease II activity
GTH21_RS25935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTH21_RS25940	COG1960	acyl-CoA dehydrogenase activity
GTH21_RS25950	COG3650	response to hydrogen peroxide
GTH21_RS25955	COG1073	alpha beta
GTH21_RS26015	COG2965	DNA replication, synthesis of RNA primer
GTH21_RS26020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTH21_RS26030	COG3061	Opacity-associated protein A
GTH21_RS26035	COG0545	Peptidyl-prolyl cis-trans isomerase
GTH21_RS26040	COG1113	amino acid transport
GTH21_RS26050	COG0697	spore germination
GTH21_RS26060	COG0702	epimerase
GTH21_RS26065	COG1733	regulation of RNA biosynthetic process
GTH21_RS26080	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GTH21_RS26105	COG1253	flavin adenine dinucleotide binding
GTH21_RS26115	COG0729	surface antigen
GTH21_RS26120	COG2911	Protein conserved in bacteria
GTH21_RS26125	COG2105	PFAM AIG2 family protein
GTH21_RS26140	COG1879	ABC-type sugar transport system periplasmic component
GTH21_RS26145	COG1129	ABC transporter
GTH21_RS26150	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS26155	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH21_RS26165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTH21_RS26190	COG0312	modulator of DNA gyrase
GTH21_RS26230	COG3964	amidohydrolase
GTH21_RS26245	COG2706	6-phosphogluconolactonase activity
GTH21_RS26250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH21_RS26250	COG3711	transcriptional antiterminator
GTH21_RS26255	COG3077	Addiction module antitoxin, RelB DinJ family
GTH21_RS26260	COG2026	Addiction module toxin, RelE StbE family
GTH21_RS26265	COG0602	queuosine metabolic process
GTH21_RS26290	COG1486	melibiose metabolic process
GTH21_RS26295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH21_RS26300	COG0366	Alpha amylase catalytic
GTH21_RS26305	COG1263	PTS System
GTH21_RS26305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH21_RS26345	COG2731	YhcH YjgK YiaL family protein
GTH21_RS26355	COG2222	sugar isomerase
GTH21_RS26360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS26365	COG1228	amidohydrolase
GTH21_RS26370	COG1288	antiporter activity
GTH21_RS26375	COG2188	Transcriptional regulator
GTH21_RS26400	COG0525	valine-tRNA ligase activity
GTH21_RS26405	COG2927	DNA polymerase III (CHI subunit)
GTH21_RS26415	COG0795	lipopolysaccharide-transporting ATPase activity
GTH21_RS26420	COG0795	lipopolysaccharide-transporting ATPase activity
GTH21_RS26425	COG0433	COG0433 Predicted ATPase
GTH21_RS26440	COG3718	enzyme involved in inositol metabolism
GTH21_RS26450	COG0837	glucose binding
GTH21_RS26450	COG1737	Transcriptional regulator
GTH21_RS26455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH21_RS26465	COG3962	Belongs to the TPP enzyme family
GTH21_RS26475	COG1082	Xylose isomerase domain protein TIM barrel
GTH21_RS26490	COG3842	ATPase activity
GTH21_RS26495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GTH21_RS26500	COG0395	ABC-type sugar transport system, permease component
GTH21_RS26505	COG1175	transmembrane transport
GTH21_RS26510	COG1064	alcohol dehydrogenase
GTH21_RS26515	COG0659	secondary active sulfate transmembrane transporter activity
GTH21_RS26520	COG0288	reversible hydration of carbon dioxide
GTH21_RS26530	COG0582	viral genome integration into host DNA
GTH21_RS26575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GTH21_RS26595	COG3596	GTP binding
GTH21_RS26610	COG2003	Belongs to the UPF0758 family
GTH21_RS26725	COG3507	Belongs to the glycosyl hydrolase 43 family
GTH21_RS26730	COG2211	Major facilitator Superfamily
GTH21_RS26735	COG2115	Belongs to the xylose isomerase family
GTH21_RS26745	COG4580	involved in the transport of maltose and maltodextrins
GTH21_RS26750	COG3272	Protein of unknown function (DUF1722)
GTH21_RS26770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTH21_RS26785	COG0300	oxidoreductase activity
GTH21_RS26790	COG3631	Ketosteroid isomerase-related protein
GTH21_RS26795	COG0789	Transcriptional regulator
GTH21_RS26800	COG3040	lipid binding
GTH21_RS26810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH21_RS26815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS26820	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS26825	COG1538	Outer membrane efflux protein
GTH21_RS26830	COG0745	RESPONSE REGULATOR receiver
GTH21_RS26835	COG5002	protein histidine kinase activity
GTH21_RS26850	COG2850	peptidyl-arginine hydroxylation
GTH21_RS27045	COG2199	diguanylate cyclase activity
GTH21_RS27045	COG2203	Gaf domain
GTH21_RS27050	COG1716	ATPase activity
GTH21_RS27050	COG5001	Diguanylate cyclase
GTH21_RS27065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GTH21_RS27075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTH21_RS27120	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH21_RS27150	COG0739	heme binding
GTH21_RS27160	COG2132	Multicopper oxidase
GTH21_RS27165	COG3667	copper resistance
GTH21_RS27170	COG2372	response to copper ion
GTH21_RS27175	COG1276	copper resistance
GTH21_RS27180	COG0745	RESPONSE REGULATOR receiver
GTH21_RS27185	COG2205	protein histidine kinase activity
GTH21_RS27205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTH21_RS27220	COG0431	NADPH-dependent FMN reductase
GTH21_RS27250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTH21_RS27315	COG2801	Transposase and inactivated derivatives
GTH21_RS27325	COG2801	Transposase and inactivated derivatives
GTH21_RS27335	COG0501	Belongs to the peptidase M48B family
GTH21_RS27350	COG0542	response to heat
GTH21_RS27355	COG0071	Belongs to the small heat shock protein (HSP20) family
GTH21_RS27450	COG3173	Aminoglycoside phosphotransferase
GTH21_RS27475	COG1695	Transcriptional regulator
GTH21_RS27510	COG5499	transcription regulator containing HTH domain
GTH21_RS27805	COG2135	peptidase activity
GTH21_RS27845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTH21_RS27860	COG3655	Transcriptional regulator
GTH21_RS27875	COG2205	protein histidine kinase activity
GTH21_RS27890	COG2194	sulfuric ester hydrolase activity
GTH21_RS28010	COG3344	reverse transcriptase
GTH21_RS28085	COG1475	DNA binding
GTH21_RS28240	COG3173	Aminoglycoside phosphotransferase
GTH21_RS28265	COG1695	Transcriptional regulator
GTH21_RS28320	COG1983	PspC domain protein
GTH21_RS28330	COG1842	Phage shock protein A
GTH21_RS28335	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTH21_RS28345	COG1028	Short-chain dehydrogenase reductase Sdr
GTH21_RS28350	COG1546	Belongs to the CinA family
GTH21_RS28365	COG3111	PFAM Bacterial OB fold (BOF) protein
GTH21_RS28455	COG3344	reverse transcriptase
GTH21_RS28470	COG1192	Involved in chromosome partitioning
GTH21_RS28935	COG5499	transcription regulator containing HTH domain
GTH21_RS29045	COG4221	oxidoreductase activity
GTH21_RS29100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GTH21_RS29130	COG3344	reverse transcriptase
GTH21_RS29370	COG1192	Involved in chromosome partitioning
GTH21_RS29380	COG1192	Involved in chromosome partitioning
GTH21_RS29410	COG2026	Addiction module toxin, RelE StbE family