locus-tag class description FLM33_RS00015 ENOG4108MG9 hydrogenase 3 maturation protease FLM33_RS00020 ENOG4105I6X formate hydrogenlyase maturation FLM33_RS00025 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FLM33_RS00030 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit FLM33_RS00035 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FLM33_RS00040 ENOG4107TDF Formate hydrogenlyase subunit 4 FLM33_RS00045 ENOG4107R30 NADH dehydrogenase FLM33_RS00050 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FLM33_RS00055 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA FLM33_RS00060 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FLM33_RS00065 ENOG4107RSS Hydrogenase accessory protein HypB FLM33_RS00070 ENOG41083WG hydrogenase assembly chaperone FLM33_RS00075 ENOG4105CQS hydrogenase expression formation protein HypD FLM33_RS00080 ENOG4105C45 hydrogenase expression formation protein (HypE) FLM33_RS00090 ENOG4105CS2 ec 3.2.1.21 FLM33_RS00100 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FLM33_RS00105 ENOG4105CK1 PTS System FLM33_RS00110 ENOG4105VZJ PTS System FLM33_RS00115 ENOG4105CK1 PTS System FLM33_RS00120 ENOG4105VCP PTS System FLM33_RS00125 ENOG4105DKQ ROK family FLM33_RS00130 ENOG4105DDV Transcriptional regulator (LacI family FLM33_RS00135 ENOG4105DSE periplasmic solute binding protein FLM33_RS00140 ENOG4105DIK (ABC) transporter FLM33_RS00145 ENOG4105CC5 ABC transporter FLM33_RS00150 ENOG4105CC5 ABC transporter FLM33_RS00155 ENOG4105VXR cytoplasmic protein FLM33_RS00165 ENOG4108N2Y auxin Efflux FLM33_RS00185 ENOG4106QJH hemin transport protein FLM33_RS00190 ENOG4107R4I Periplasmic binding protein FLM33_RS00195 ENOG4105EHG Permease protein FLM33_RS00200 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS00220 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FLM33_RS00230 ENOG4105KZM cytoplasmic protein FLM33_RS00235 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FLM33_RS00240 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FLM33_RS00265 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLM33_RS00270 ENOG4108K5P (LipO)protein FLM33_RS00275 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FLM33_RS00285 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FLM33_RS00290 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FLM33_RS00295 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FLM33_RS00300 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FLM33_RS00305 ENOG4105N0Z inner membrane protein ygbE FLM33_RS00310 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FLM33_RS00320 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FLM33_RS00325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FLM33_RS00330 ENOG4108MXK alkaline phosphatase isozyme conversion FLM33_RS00335 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FLM33_RS00340 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FLM33_RS00345 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FLM33_RS00350 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FLM33_RS00355 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FLM33_RS00365 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FLM33_RS00370 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FLM33_RS00375 ENOG4105DXN mazG family FLM33_RS00380 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FLM33_RS00385 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FLM33_RS00390 ENOG4105BZU Histidine kinase FLM33_RS00395 ENOG4105BZW Glycerate kinase FLM33_RS00400 ENOG4105EQX glucarate dehydratase FLM33_RS00405 ENOG4105EQX glucarate dehydratase FLM33_RS00410 ENOG4105DJB Major Facilitator Superfamily FLM33_RS00415 ENOG4105QDK Flavodoxin FLM33_RS00420 ENOG4105DR9 pseudouridine synthase FLM33_RS00425 ENOG4105WP7 tRNA pseudouridine synthase C FLM33_RS00430 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FLM33_RS00435 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FLM33_RS00440 ENOG4105EWT decarboxylase family FLM33_RS00445 ENOG4105C44 Serine transporter FLM33_RS00450 ENOG4105EJQ L-serine dehydratase FLM33_RS00455 ENOG4105GVF (ABC) transporter FLM33_RS00465 ENOG41079KZ Major Facilitator Superfamily FLM33_RS00470 ENOG4105D01 (LipO)protein FLM33_RS00475 ENOG4108UMI ABC transporter, permease FLM33_RS00480 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS00495 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FLM33_RS00505 ENOG4108JU7 Transcriptional regulator FLM33_RS00510 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FLM33_RS00515 ENOG4105C0A alcohol dehydrogenase FLM33_RS00520 ENOG4107W7X Aldolase FLM33_RS00525 ENOG4105EDR glucose galactose transporter FLM33_RS00530 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) FLM33_RS00535 ENOG4105CMG Carbohydrate kinase FLM33_RS00540 ENOG4105NWF RbsD or FucU transport FLM33_RS00545 ENOG4107EDW L-fucose operon activator FLM33_RS00555 ENOG4105M08 Membrane FLM33_RS00560 ENOG4105ETT transcriptional Regulator, LysR family FLM33_RS00565 ENOG4105M5B (LipO)protein FLM33_RS00570 ENOG4105C9B Cysteine desulfurase FLM33_RS00575 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FLM33_RS00580 ENOG4105CUZ uba thif-type nad fad binding protein FLM33_RS00585 ENOG4105CA3 membrane-bound lytic murein transglycosylase FLM33_RS00605 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FLM33_RS00610 ENOG4108YZT Adenosylcobinamide kinase FLM33_RS00615 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FLM33_RS00625 ENOG4108V4M Cobalt abc transporter FLM33_RS00630 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FLM33_RS00635 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FLM33_RS00640 ENOG4105DVK Precorrin-2 c20-methyltransferase FLM33_RS00645 ENOG4107PPM cobalt chelatase FLM33_RS00650 ENOG4105QUC reductase FLM33_RS00655 ENOG4105E4R Precorrin-3B C17-methyltransferase FLM33_RS00660 ENOG4108P62 biosynthesis protein (CbiG) FLM33_RS00665 ENOG4105CIA precorrin-4 C(11)-methyltransferase FLM33_RS00670 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase FLM33_RS00675 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase FLM33_RS00680 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FLM33_RS00685 ENOG41081F0 Precorrin-8x methylmutase FLM33_RS00690 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FLM33_RS00695 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FLM33_RS00700 ENOG4107XVH Transcriptional regulator FLM33_RS00705 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FLM33_RS00710 ENOG4105KNY Microcompartments protein FLM33_RS00715 ENOG4105EHR propanediol utilization protein pduB FLM33_RS00720 ENOG4105DMB glycerol dehydratase FLM33_RS00725 ENOG4105YCI dehydratase medium subunit FLM33_RS00730 ENOG4108ZFT Dehydratase small subunit FLM33_RS00735 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit FLM33_RS00745 ENOG4105KNY Microcompartments protein FLM33_RS00750 ENOG4105KNY Microcompartments protein FLM33_RS00765 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FLM33_RS00775 ENOG4108EKI Dehydrogenase FLM33_RS00780 ENOG4105C0A alcohol dehydrogenase FLM33_RS00785 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) FLM33_RS00795 ENOG4105M3W utilization protein FLM33_RS00800 ENOG4105KTW ethanolamine utilization protein FLM33_RS00805 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FLM33_RS00810 ENOG4105JZC GHMP kinase FLM33_RS00815 ENOG4107QZB decarboxylase FLM33_RS00820 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLM33_RS00825 ENOG4107QZM n-acetylglutamate synthase FLM33_RS00835 ENOG4107QYX exodeoxyribonuclease v alpha FLM33_RS00840 ENOG4107QKA exodeoxyribonuclease V beta FLM33_RS00845 ENOG4107QXK peptidase FLM33_RS00850 ENOG4105DSY exodeoxyribonuclease V, gamma FLM33_RS00855 ENOG4105RVB Prepilin peptidase dependent protein c FLM33_RS00860 ENOG4105SEN Protein of unknown function (DUF2509) FLM33_RS00865 ENOG4105JCS prepilin peptidase dependent protein FLM33_RS00870 ENOG4105IPU prepilin peptidase dependent protein A FLM33_RS00875 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FLM33_RS00880 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FLM33_RS00885 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FLM33_RS00890 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FLM33_RS00900 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FLM33_RS00905 ENOG4105EE5 Membrane protein terC FLM33_RS00910 ENOG4105SUV lipoprotein YgdR FLM33_RS00915 ENOG4105CPC Aldo Keto reductase FLM33_RS00920 ENOG4107S74 Lysophospholipid transporter LplT FLM33_RS00925 ENOG4105CEY Amp-dependent synthetase and ligase FLM33_RS00930 ENOG41060NJ transcriptional regulator FLM33_RS00940 ENOG4107YCY Transcriptional regulator FLM33_RS00945 ENOG4105CS2 ec 3.2.1.21 FLM33_RS00950 ENOG4105CK1 PTS System FLM33_RS00955 ENOG4105DDV Transcriptional regulator (LacI family FLM33_RS00965 ENOG4105RQF LysR family Transcriptional regulator FLM33_RS00975 ENOG4105M5J Cupin 2, conserved barrel domain protein FLM33_RS00985 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FLM33_RS00990 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FLM33_RS00995 ENOG4108IJ9 (ABC) transporter FLM33_RS01010 ENOG4108HKT sucrose-6-phosphate hydrolase FLM33_RS01015 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FLM33_RS01025 ENOG4106NDP Transcriptional regulator FLM33_RS01030 ENOG4107QNK )-transporter FLM33_RS01035 ENOG4105CHR reductase FLM33_RS01040 ENOG4105CAZ oligogalacturonide lyase FLM33_RS01045 ENOG4108QGT oligogalacturonate-specific porin FLM33_RS01050 ENOG4105CHU acetyl-coa acetyltransferase FLM33_RS01055 ENOG4105C5Q Transcriptional regulator FLM33_RS01065 ENOG4108MHD transport protein FLM33_RS01070 ENOG4107S5I aldo keto reductase FLM33_RS01120 ENOG4108KTG Membrane protein, drug metabolite transporter FLM33_RS01125 ENOG4108ZT1 Transcriptional regulator FLM33_RS01130 ENOG4105D7X high-affinity nickel-transporter FLM33_RS01135 ENOG4108W9T type 1 fimbriae regulatory protein FLM33_RS01140 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off FLM33_RS01145 ENOG4108RQP Major type 1 subunit fimbrin FLM33_RS01150 ENOG4108S54 Fimbrial protein FLM33_RS01155 ENOG4108NAE Fimbrial chaperone protein FLM33_RS01160 ENOG4105CW0 outer membrane usher protein FLM33_RS01165 ENOG4108SQA Fimbrial FLM33_RS01170 ENOG4108T65 Fimbrial FLM33_RS01175 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin FLM33_RS01185 ENOG410830R acetyltransferase FLM33_RS01190 ENOG4105VR1 Pfam:DUF1271 FLM33_RS01200 ENOG4105J12 Multidrug resistance protein mdtN FLM33_RS01205 ENOG4108MI0 Resistance protein FLM33_RS01210 ENOG4105ETP RND efflux system, outer membrane lipoprotein FLM33_RS01215 ENOG4105V2F Uncharacterized protein yoac FLM33_RS01220 ENOG4105DUX Transporter FLM33_RS01225 ENOG4105K89 arsenate reductase FLM33_RS01230 ENOG4107R5R arsenical pump membrane protein FLM33_RS01250 ENOG4105W7K Transcriptional regulator FLM33_RS01265 ENOG4105CPC Aldo Keto reductase FLM33_RS01280 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLM33_RS01290 ENOG4108K5P (LipO)protein FLM33_RS01295 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FLM33_RS01300 ENOG4105CRK lysyL-tRNA synthetase FLM33_RS01310 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FLM33_RS01315 ENOG4105T95 Thiol disulfide interChange protein FLM33_RS01320 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FLM33_RS01325 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FLM33_RS01330 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB FLM33_RS01335 ENOG4105Y75 tpr repeat protein FLM33_RS01345 ENOG4108UT2 hemolysin iii FLM33_RS01350 ENOG4105N5Z UPF0267 protein FLM33_RS01355 ENOG4108Q3X Transcriptional regulator FLM33_RS01360 ENOG4105CS2 ec 3.2.1.21 FLM33_RS01380 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLM33_RS01385 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FLM33_RS01390 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FLM33_RS01395 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FLM33_RS01400 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FLM33_RS01405 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FLM33_RS01410 ENOG4105D0A hydroxylase FLM33_RS01415 ENOG4107RAQ aminopeptidase FLM33_RS01420 ENOG4105E07 UPF0149 protein FLM33_RS01425 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FLM33_RS01435 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FLM33_RS01440 ENOG4108JQ1 Dehydrogenase FLM33_RS01445 ENOG4105E66 phosphoriboisomerase A FLM33_RS01450 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FLM33_RS01455 ENOG4105MPN Membrane FLM33_RS01460 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FLM33_RS01465 ENOG4105D64 Mechanosensitive ion channel FLM33_RS01470 ENOG4105D2N Aldolase FLM33_RS01480 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FLM33_RS01485 ENOG4105CV1 Transketolase (EC 2.2.1.1) FLM33_RS01490 ENOG4108K0D peptidase, M48 FLM33_RS01495 ENOG4105J5J Outer membrane porin FLM33_RS01510 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) FLM33_RS01515 ENOG4105CHR reductase FLM33_RS01535 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FLM33_RS01545 ENOG4108FUF Transcriptional regulator, IclR family FLM33_RS01550 ENOG4105CHR reductase FLM33_RS01575 ENOG4105CYW agmatinase FLM33_RS01595 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FLM33_RS01600 ENOG4107QNK )-transporter FLM33_RS01605 ENOG4105GPY SprT protein FLM33_RS01610 ENOG4105RWS endonuclease I FLM33_RS01615 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FLM33_RS01620 ENOG4105D7Z glutathione synthase FLM33_RS01625 ENOG4108UJU UPF0301 protein FLM33_RS01630 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FLM33_RS01635 ENOG41086KC Transcriptional regulator FLM33_RS01640 ENOG4105CZX twitching motility protein FLM33_RS01645 ENOG4105DFA alanine racemase domain protein FLM33_RS01650 ENOG4108VIA integral membrane protein FLM33_RS01655 ENOG4105VZ9 UPF0235 protein FLM33_RS01660 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FLM33_RS01665 ENOG4105CSA Coproporphyrinogen iii oxidase FLM33_RS01670 ENOG4105K33 Periplasmic Protein FLM33_RS01675 ENOG41090ED Protein with unknown function (DUF469) FLM33_RS01680 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FLM33_RS01685 ENOG4105CEN a g-specific adenine glycosylase FLM33_RS01690 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FLM33_RS01695 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FLM33_RS01700 ENOG4105EAA nucleoside FLM33_RS01705 ENOG4105CXN decarboxylase FLM33_RS01710 ENOG4108UQV Membrane FLM33_RS01775 ENOG4105C28 cystathionine FLM33_RS01780 ENOG4105CC0 LysR family Transcriptional regulator FLM33_RS01800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLM33_RS01805 ENOG4106032 Glutathionylspermidine synthase FLM33_RS01820 ENOG4105CYM Glutathione S-transferase FLM33_RS01825 ENOG410900S Protein of unknown function (DUF2623) FLM33_RS01835 ENOG4108TEB UPF0114 protein FLM33_RS01840 ENOG4105E4I Glycoside hydrolase family 28 FLM33_RS01845 ENOG4105CT4 transporter FLM33_RS01850 ENOG4108ZZF transport protein (ExbD) FLM33_RS01855 ENOG4105CWK Biopolymer transport protein, ExbB FLM33_RS01860 ENOG4105C28 cystathionine FLM33_RS01865 ENOG4108K81 inner membrane protein YghB FLM33_RS01870 ENOG4105CF7 AraC family transcriptional regulator FLM33_RS01875 ENOG4108I6A alcohol dehydrogenase FLM33_RS01880 ENOG4105CV8 reductase FLM33_RS01890 ENOG4105CCT upf0313 protein FLM33_RS01895 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FLM33_RS01900 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FLM33_RS01905 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLM33_RS01910 ENOG4105F4I Transcriptional regulator FLM33_RS01915 ENOG4105H4F exported protein FLM33_RS01920 ENOG4105XJC Two component transcriptional regulator (Winged helix family FLM33_RS01925 ENOG4105DHQ Histidine kinase FLM33_RS01930 ENOG4105NF4 modulator of drug activity FLM33_RS01935 ENOG4105VRH Antibiotic biosynthesis monooxygenase FLM33_RS01940 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLM33_RS01945 ENOG4105IPS esterase FLM33_RS01950 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FLM33_RS01955 ENOG4108SX3 cytoplasmic protein FLM33_RS01960 ENOG41087AY ADP-Ribose pyrophosphatase FLM33_RS01970 ENOG4105F1G UPF0441 protein FLM33_RS01975 ENOG4106032 Glutathionylspermidine synthase FLM33_RS01980 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FLM33_RS01995 ENOG4105W0Z cytoplasmic protein FLM33_RS02010 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FLM33_RS02015 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FLM33_RS02020 ENOG4105I7R Adenylate cyclase FLM33_RS02025 ENOG4106MWK domain protein FLM33_RS02030 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FLM33_RS02035 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FLM33_RS02040 ENOG4107ZVW dihydroneopterin aldolase FLM33_RS02045 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FLM33_RS02060 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FLM33_RS02065 ENOG4108YZ9 Urea amidohydrolase subunit gamma FLM33_RS02070 ENOG4105KI2 Urea amidohydrolase subunit beta FLM33_RS02075 ENOG4105CQM Urea amidohydrolase subunit alpha FLM33_RS02080 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) FLM33_RS02085 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FLM33_RS02090 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FLM33_RS02100 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FLM33_RS02110 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FLM33_RS02115 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLM33_RS02120 ENOG4108VCA G U mismatch-specific DNA glycosylase FLM33_RS02140 ENOG4108WQH regulatoR FLM33_RS02145 ENOG4105BZU Histidine kinase FLM33_RS02150 ENOG4108V08 YfdX protein FLM33_RS02155 ENOG4108YK4 Acid-resistance membrane protein FLM33_RS02160 ENOG4105XXV Acid-resistance protein FLM33_RS02165 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FLM33_RS02170 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit FLM33_RS02175 ENOG4108ZFT Dehydratase small subunit FLM33_RS02180 ENOG4105YCI dehydratase medium subunit FLM33_RS02195 ENOG4105C0A alcohol dehydrogenase FLM33_RS02225 ENOG4105CMT Dihydroxyacetone kinase FLM33_RS02230 ENOG4108UTZ Dihydroxyacetone kinase FLM33_RS02245 ENOG4105Q26 Siderophore-interacting protein FLM33_RS02250 ENOG4105NTW Transcriptional regulator FLM33_RS02255 ENOG4105C8Y Acetylornithine aminotransferase FLM33_RS02260 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FLM33_RS02265 ENOG41061GT Aldolase FLM33_RS02270 ENOG4105D4B ABC, transporter FLM33_RS02275 ENOG4105F5R ABC transporter FLM33_RS02280 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FLM33_RS02285 ENOG4105C2J ABC transporter FLM33_RS02290 ENOG4105DKT Transcriptional regulator FLM33_RS02295 ENOG4107RYS Autoinducer-2 (AI-2) kinase FLM33_RS02300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLM33_RS02305 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FLM33_RS02320 ENOG4108VKG metal-dependent hydrolase FLM33_RS02325 ENOG4105EE0 oxidoreductase FLM33_RS02330 ENOG4105DU1 integral membrane protein, terc FLM33_RS02335 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FLM33_RS02340 ENOG4105P66 Membrane FLM33_RS02345 ENOG4105CTX dehydratase FLM33_RS02355 ENOG4105DPW Major facilitator superfamily MFS_1 FLM33_RS02360 ENOG4107YCY Transcriptional regulator FLM33_RS02365 ENOG4106W5V Membrane FLM33_RS02370 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) FLM33_RS02375 ENOG4105WAY exported protein FLM33_RS02380 ENOG4105NE1 Conserved Protein FLM33_RS02385 ENOG41090KG Inner membrane protein YqjE FLM33_RS02390 ENOG4105YJD FLM33_RS02395 ENOG4108VBZ doxx family FLM33_RS02400 ENOG4105CHF Glutathione S-transferase FLM33_RS02405 ENOG4105KAF membrAne FLM33_RS02410 ENOG4105CWB LysR family transcriptional Regulator FLM33_RS02415 ENOG4108CNN domain protein FLM33_RS02420 ENOG4106D80 Uncharacterized protein YhaL FLM33_RS02440 ENOG4105BZW Glycerate kinase FLM33_RS02445 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FLM33_RS02450 ENOG4105CNV Aldolase FLM33_RS02455 ENOG4105DJB Major Facilitator Superfamily FLM33_RS02460 ENOG4105CTX dehydratase FLM33_RS02465 ENOG4107UEK pfkb domain protein FLM33_RS02470 ENOG4105E98 transcriptional regulator DeoR family FLM33_RS02475 ENOG4105D2N Aldolase FLM33_RS02480 ENOG4105DE4 1-phosphofructokinase FLM33_RS02485 ENOG4105DM4 PTS System FLM33_RS02490 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FLM33_RS02495 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of FLM33_RS02500 ENOG41082GB PTS system galactitol-specific transporter subunit IIA FLM33_RS02505 ENOG41090UW PTS System FLM33_RS02510 ENOG4105DT3 PTS system, galactitol-specific IIc component FLM33_RS02515 ENOG4107WTH Galactitol-1-phosphate dehydrogenase FLM33_RS02535 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FLM33_RS02540 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FLM33_RS02545 ENOG41082RQ UPF0102 protein FLM33_RS02550 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FLM33_RS02555 ENOG4105W4M Transport-associated protein FLM33_RS02560 ENOG4107S21 permease FLM33_RS02565 ENOG4105K4T epimerase FLM33_RS02570 ENOG4107R7Y intracellular protease Pfpi family FLM33_RS02575 ENOG4108ZPB UPF0306 protein FLM33_RS02580 ENOG41082IR Excinuclease ABC C subunit domain protein FLM33_RS02585 ENOG4108YYD acetyltransferase FLM33_RS02605 ENOG4105DEN Luciferase family FLM33_RS02610 ENOG4105CIC tryptophan-specific transport protein FLM33_RS02615 ENOG4105C1J atp-dependent rna helicase FLM33_RS02630 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FLM33_RS02635 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FLM33_RS02640 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FLM33_RS02645 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FLM33_RS02650 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FLM33_RS02655 ENOG4105CHV Transcription elongation factor NusA FLM33_RS02660 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FLM33_RS02670 ENOG4105CDH Citrulline--aspartate ligase FLM33_RS02675 ENOG4108PNB DNA-binding transcriptional regulator FLM33_RS02680 ENOG4108UII YfaZ family FLM33_RS02695 ENOG4105NTZ Preprotein translocase subunit SecG FLM33_RS02700 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FLM33_RS02705 ENOG4105EEI dihydropteroate synthase FLM33_RS02710 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FLM33_RS02715 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FLM33_RS02720 ENOG4105HBR Rna-binding protein FLM33_RS02725 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FLM33_RS02730 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FLM33_RS02735 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FLM33_RS02740 ENOG4105QYV Membrane FLM33_RS02745 ENOG4105K46 50S ribosomal protein l27 FLM33_RS02750 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FLM33_RS02755 ENOG4105EAH synthase FLM33_RS02760 ENOG4105HVQ Regulatory factor of maltose metabolism FLM33_RS02765 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FLM33_RS02770 ENOG4105VFK BolA family FLM33_RS02775 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FLM33_RS02780 ENOG4105E3I toluene tolerance FLM33_RS02785 ENOG4107PE3 Mammalian cell entry related domain protein FLM33_RS02790 ENOG4105CY3 ABC transporter, permease FLM33_RS02795 ENOG4105DHJ ABC, transporter FLM33_RS02800 ENOG4105FEU K -dependent Na -Ca exchanger FLM33_RS02805 ENOG4105C2X Arabinose 5-phosphate isomerase FLM33_RS02810 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FLM33_RS02815 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FLM33_RS02820 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FLM33_RS02825 ENOG4108IUZ ABC transporter FLM33_RS02830 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLM33_RS02835 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FLM33_RS02840 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FLM33_RS02845 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FLM33_RS02850 ENOG41080Z8 PHOSPHOCARRIER protein FLM33_RS02860 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FLM33_RS02865 ENOG4105BZU Histidine kinase FLM33_RS02870 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FLM33_RS02875 ENOG4105CPQ Dehydrogenase FLM33_RS02880 ENOG4108I5G Major Facilitator superfamily FLM33_RS02885 ENOG4105N5T Radical SAM Protein FLM33_RS02890 ENOG4105CBC glutamate synthase FLM33_RS02895 ENOG4105BZ8 glutamate synthase FLM33_RS02900 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) FLM33_RS02905 ENOG4105KB2 stringent starvation protein b FLM33_RS02910 ENOG4107MKT Stringent starvation protein a FLM33_RS02920 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FLM33_RS02925 ENOG4105D6Z AFG1 family ATPase FLM33_RS02930 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FLM33_RS02935 ENOG4105C0H protease FLM33_RS02940 ENOG4105C0H protease FLM33_RS02945 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FLM33_RS02950 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FLM33_RS02955 ENOG4105RID UPF0379 protein yhcN FLM33_RS02960 ENOG4105RID UPF0379 protein yhcN FLM33_RS02965 ENOG4105UNR (Barnase) inhibitor FLM33_RS02970 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) FLM33_RS02985 ENOG4105CR8 Transcriptional regulator FLM33_RS02990 ENOG4105D1U peptidase U62 modulator of DNA gyrase FLM33_RS02995 ENOG4105QD6 exported protein FLM33_RS03000 ENOG4105C03 ribonuclease FLM33_RS03005 ENOG4108Z03 MAF-like protein FLM33_RS03010 ENOG4105VQ7 Rod shape-determining protein MreD FLM33_RS03015 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FLM33_RS03025 ENOG41062P1 Diguanylate cyclase phosphodiesterase FLM33_RS03040 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FLM33_RS03050 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FLM33_RS03055 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FLM33_RS03060 ENOG4105RG0 Membrane FLM33_RS03065 ENOG4108IA2 Sodium pantothenate symporter FLM33_RS03070 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FLM33_RS03075 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FLM33_RS03100 ENOG4108XG4 DNA-binding transcriptional regulator FLM33_RS03105 ENOG4105C1P efflux transporter, rnd family, mfp subunit FLM33_RS03110 ENOG4105BZS acriflavin resistance protein FLM33_RS03115 ENOG4105XCM membrane LIPOPROTEIN FLM33_RS03145 ENOG4108Z0R Transferase FLM33_RS03150 ENOG4105SG3 Protein of unknown function (DUF1488) FLM33_RS03155 ENOG4105E2X shikimate dehydrogenase FLM33_RS03160 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FLM33_RS03165 ENOG4108WI1 Dna topoisomerase FLM33_RS03175 ENOG4105C79 DNA protecting protein DprA FLM33_RS03180 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FLM33_RS03185 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FLM33_RS03190 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FLM33_RS03195 ENOG4105C1A potassium transporter peripheral membrane FLM33_RS03200 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FLM33_RS03205 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FLM33_RS03210 ENOG4105W1Y Transcriptional regulator FLM33_RS03215 ENOG4105VTS DnaJ-like, subfamily C FLM33_RS03220 ENOG4108ZT0 50S ribosomal protein l17 FLM33_RS03225 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLM33_RS03230 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FLM33_RS03235 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FLM33_RS03240 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FLM33_RS03245 ENOG41067V7 50S ribosomal protein L36 FLM33_RS03250 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FLM33_RS03255 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FLM33_RS03260 ENOG4105VPB 50S ribosomal protein L30 FLM33_RS03265 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FLM33_RS03275 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FLM33_RS03280 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FLM33_RS03295 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FLM33_RS03300 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FLM33_RS03305 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FLM33_RS03310 ENOG41083MP 50s ribosomal protein l29 FLM33_RS03315 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FLM33_RS03320 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FLM33_RS03325 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FLM33_RS03330 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FLM33_RS03335 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FLM33_RS03345 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FLM33_RS03350 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FLM33_RS03365 ENOG4108UQY Iron-storage protein FLM33_RS03370 ENOG4105W53 bacterioferritin-associated ferredoxin FLM33_RS03375 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FLM33_RS03380 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FLM33_RS03385 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FLM33_RS03390 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FLM33_RS03395 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FLM33_RS03400 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FLM33_RS03405 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FLM33_RS03410 ENOG4105WWK YheO domain protein FLM33_RS03415 ENOG4108V1T peptidylprolyl cis-trans isomerase FLM33_RS03420 ENOG4105VRX Protein slyX homolog FLM33_RS03425 ENOG4108YZY peptidylprolyl cis-trans isomerase FLM33_RS03430 ENOG4105VKU nucleicacid-binding protein FLM33_RS03435 ENOG4105CKD glutathione-regulated potassium-efflux system protein FLM33_RS03440 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FLM33_RS03445 ENOG4105C5H ABC transporter FLM33_RS03450 ENOG4105DNZ Alpha Beta Hydrolase FLM33_RS03455 ENOG4105YP7 UPF0270 protein FLM33_RS03460 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FLM33_RS03465 ENOG4108UKZ OsmC family FLM33_RS03470 ENOG4107RYR Transcriptional regulator, Crp Fnr family FLM33_RS03475 ENOG410613R integral membrane protein, YccS YhfK family FLM33_RS03480 ENOG4105C8Y Acetylornithine aminotransferase FLM33_RS03490 ENOG4105MZU cell filamentation protein FLM33_RS03495 ENOG4106195 uncharacterized protein yhfG FLM33_RS03500 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FLM33_RS03505 ENOG4106DTQ Protein TsgA homolog FLM33_RS03510 ENOG4105DZC cytosine deaminase FLM33_RS03515 ENOG4107QZF nitrite reductase NADPH large subunit FLM33_RS03520 ENOG4105WZK nitrite reductase NADPH small subunit FLM33_RS03525 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FLM33_RS03530 ENOG4105C31 Tryptophanyl-tRNA synthetase FLM33_RS03540 ENOG4105DJV ribulose-phosphate 3-epimerase FLM33_RS03545 ENOG4105DFE Dna adenine methylase FLM33_RS03550 ENOG4105EGB membrane protein DamX FLM33_RS03555 ENOG4105D49 3-dehydroquinate synthase FLM33_RS03560 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FLM33_RS03565 ENOG4105E4G Type IV pilus FLM33_RS03590 ENOG4108JQC penicillin-binding protein 1A FLM33_RS03595 ENOG4107RK2 ADP-ribose diphosphatase NudE FLM33_RS03600 ENOG4105DQY intracellular growth attenuator FLM33_RS03605 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FLM33_RS03610 ENOG4105VEJ Heat shock protein FLM33_RS03625 ENOG4105E0F Histidine kinase FLM33_RS03635 ENOG4108RRZ Transcription elongation factor GreB FLM33_RS03640 ENOG4105BZM domain protein FLM33_RS03645 ENOG4105XFK Ferrous iron transport protein A FLM33_RS03650 ENOG4105CE1 Ferrous iron transport protein b FLM33_RS03655 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) FLM33_RS03665 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FLM33_RS03670 ENOG4105MJ2 Competence protein FLM33_RS03675 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FLM33_RS03680 ENOG4105C6Z Gluconate FLM33_RS03685 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FLM33_RS03690 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FLM33_RS03695 ENOG41061ZR Transcriptional regulator FLM33_RS03700 ENOG4105E98 transcriptional regulator DeoR family FLM33_RS03705 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FLM33_RS03710 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FLM33_RS03715 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FLM33_RS03730 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FLM33_RS03735 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FLM33_RS03740 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FLM33_RS03745 ENOG4108IUM Glycogen debranching enzyme FLM33_RS03750 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FLM33_RS03755 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FLM33_RS03765 ENOG4105C6Z Gluconate FLM33_RS03770 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FLM33_RS03775 ENOG4105DIQ Transcriptional regulator FLM33_RS03780 ENOG4105C2I pirin domain protein FLM33_RS03785 ENOG4105D9R oxidoreductase FLM33_RS03795 ENOG4105WCN acetyltransferase FLM33_RS03800 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FLM33_RS03805 ENOG4105WC8 Conserved Protein FLM33_RS03810 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FLM33_RS03825 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FLM33_RS03830 ENOG4105BZ7 extracellular solute-binding protein family 1 FLM33_RS03840 ENOG41060M8 Pfam:PhdYeFM FLM33_RS03845 ENOG4108IV0 ABC, transporter FLM33_RS03850 ENOG4105C0Z ABC transporter FLM33_RS03855 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FLM33_RS03860 ENOG4105C32 Amino acid ABC transporter (Permease) FLM33_RS03865 ENOG4105CP9 extracellular ligand-binding receptor FLM33_RS03870 ENOG4105U59 -acetyltransferase FLM33_RS03875 ENOG4105CP9 extracellular ligand-binding receptor FLM33_RS03885 ENOG4108JPW Aminotransferase FLM33_RS03900 ENOG4105CRP Part of the ABC transporter FtsEX involved in FLM33_RS03905 ENOG4105CAK Cell division ATP-binding protein ftsE FLM33_RS03910 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FLM33_RS03915 ENOG4106H78 methyltransferase FLM33_RS03920 ENOG4105MG3 Membrane FLM33_RS03930 ENOG4107FS9 Membrane FLM33_RS03940 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FLM33_RS03945 ENOG4105EX9 Membrane FLM33_RS03950 ENOG4108W1V Lipoprotein FLM33_RS03955 ENOG4105F9N Major Facilitator Superfamily FLM33_RS03960 ENOG4105DSF transport protein FLM33_RS03965 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FLM33_RS03970 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FLM33_RS03975 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FLM33_RS03980 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FLM33_RS03985 ENOG4105C3I Nad-dependent epimerase dehydratase FLM33_RS03990 ENOG4105CKK Glycosyl transferase, family 2 FLM33_RS03995 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FLM33_RS04000 ENOG4105PY6 Phenolic acid decarboxylase FLM33_RS04010 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FLM33_RS04015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLM33_RS04020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLM33_RS04030 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS04040 ENOG4105CJW magnesium transporter FLM33_RS04045 ENOG4105CBX hi0933 family FLM33_RS04050 ENOG4105CJ3 phosphate transporter FLM33_RS04055 ENOG4108V6B universal stress protein B FLM33_RS04065 ENOG4105DUX Transporter FLM33_RS04070 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FLM33_RS04075 ENOG4105DGW oligopeptidase A FLM33_RS04085 ENOG4105D6S protein involved in catabolism of external DNA FLM33_RS04090 ENOG4105DC8 reductase FLM33_RS04100 ENOG4105C0A alcohol dehydrogenase FLM33_RS04115 ENOG4105CHR reductase FLM33_RS04120 ENOG4105CBN LysR family transcriptional regulator FLM33_RS04125 ENOG4107H3J ribonuclease FLM33_RS04130 ENOG4105CSH Transporter FLM33_RS04135 ENOG41066T0 asmA family FLM33_RS04145 ENOG4105CS0 peptidase FLM33_RS04150 ENOG4105CK2 sodium dicarboxylate symporter FLM33_RS04155 ENOG4105BZU Histidine kinase FLM33_RS04160 ENOG4105EJG cellulose synthase FLM33_RS04165 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FLM33_RS04170 ENOG4107EEX Cellulose synthase regulator protein FLM33_RS04175 ENOG4107QZ7 Cellulose synthase catalytic subunit FLM33_RS04180 ENOG4105UTS cellulose synthase operon protein YhjQ FLM33_RS04185 ENOG410661M cytoplasmic protein FLM33_RS04190 ENOG4105U74 cellulose biosynthesis protein BcsE FLM33_RS04195 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT FLM33_RS04200 ENOG4105D1V cellulose synthase operon protein YhjU FLM33_RS04215 ENOG4105EJG cellulose synthase FLM33_RS04220 ENOG4107EEX Cellulose synthase regulator protein FLM33_RS04230 ENOG4107U53 septum site-determining protein minD FLM33_RS04245 ENOG4108JQ7 (ABC) transporter FLM33_RS04250 ENOG4105C3U ABC transporter FLM33_RS04255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLM33_RS04260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLM33_RS04265 ENOG4105DEF Extracellular solute-binding protein, family 5 FLM33_RS04290 ENOG4105DIJ Phosphoethanolamine transferase FLM33_RS04295 ENOG4105FCD Major Facilitator FLM33_RS04300 ENOG4105EAX Putative lipase FLM33_RS04305 ENOG4108R3E Dna-3-methyladenine glycosylase i FLM33_RS04310 ENOG4105HNP -acetyltransferase FLM33_RS04315 ENOG4107QY8 reductase FLM33_RS04320 ENOG4108ZG0 Ompa motb domain protein FLM33_RS04325 ENOG4108M60 Transcriptional regulator FLM33_RS04335 ENOG4105D7K pfkb domain protein FLM33_RS04345 ENOG4105C5I Dehydrogenase FLM33_RS04350 ENOG4106JH6 (LipO)protein FLM33_RS04355 ENOG4105D2S major facilitator superfamily FLM33_RS04360 ENOG4105MVF Transcriptional regulator FLM33_RS04370 ENOG4105C5H ABC transporter FLM33_RS04375 ENOG41060TC Hok gef cell toxic protein FLM33_RS04380 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FLM33_RS04385 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FLM33_RS04395 ENOG4105MEV Acyl-transferase FLM33_RS04400 ENOG4108Z12 YiaAB two helix domain-containing protein FLM33_RS04405 ENOG410688U Inner membrane protein yiaB FLM33_RS04410 ENOG4105CMG Carbohydrate kinase FLM33_RS04415 ENOG4105C93 Xylose Isomerase FLM33_RS04420 ENOG4105DFW ABC transporter FLM33_RS04430 ENOG4108HWW ABC transporter FLM33_RS04435 ENOG4105T16 Transcriptional regulator (AraC family) FLM33_RS04440 ENOG4108UR8 BAX protein FLM33_RS04445 ENOG4107T9C Alpha amylase catalytic region FLM33_RS04450 ENOG4105JKW Valine--pyruvate aminotransferase FLM33_RS04455 ENOG4108RC0 Electron transport protein FLM33_RS04460 ENOG4105J4Q Transcriptional regulator FLM33_RS04465 ENOG4105EM7 Selenocysteine-specific translation elongation factor FLM33_RS04470 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FLM33_RS04475 ENOG4108U78 Glutathione S-transferase FLM33_RS04480 ENOG4105EFX secretion protein, HlyD family FLM33_RS04485 ENOG4105FP6 Protein of unknown function (DUF3302) FLM33_RS04490 ENOG4105CTS PTS system mannitol-specific FLM33_RS04495 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FLM33_RS04500 ENOG4105E61 Mannitol repressor protein FLM33_RS04510 ENOG4108YYI Protein of unknown function (DUF2810) FLM33_RS04515 ENOG4105DAA L-lactate FLM33_RS04520 ENOG41073TP transcriptional regulator FLM33_RS04525 ENOG4105DMF Dehydrogenase FLM33_RS04530 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FLM33_RS04535 ENOG4105D7W serine acetyltransferase FLM33_RS04540 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FLM33_RS04545 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FLM33_RS04550 ENOG4105VW4 glutaredoxin 3 FLM33_RS04555 ENOG4107YZP Rhodanese domain protein FLM33_RS04565 ENOG41063SB peptidase FLM33_RS04570 ENOG4105PXI polysaccharide deacetylase FLM33_RS04575 ENOG4106WTF Glycosyl transferase, family 2 FLM33_RS04580 ENOG4105CPQ Dehydrogenase FLM33_RS04585 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FLM33_RS04590 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FLM33_RS04595 ENOG4105XA0 heptosyltransferase ii FLM33_RS04600 ENOG4105D16 lipopolysaccharide heptosyltransferase i FLM33_RS04625 ENOG4105DKP glycosyl transferase, family 9 FLM33_RS04635 ENOG4105CPK Glycosyl transferase (Group 1 FLM33_RS04640 ENOG4105K64 Glycosyl transferase, family 2 FLM33_RS04645 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FLM33_RS04650 ENOG4106WTF Glycosyl transferase, family 2 FLM33_RS04655 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FLM33_RS04660 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FLM33_RS04665 ENOG4105W0E 50S ribosomal protein L33 FLM33_RS04670 ENOG4105KDC 50s ribosomal protein l28 FLM33_RS04675 ENOG4105W5Q DNA repair protein (RadC FLM33_RS04680 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FLM33_RS04685 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FLM33_RS04690 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FLM33_RS04700 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FLM33_RS04705 ENOG4107QWP ABC-2 type transporter FLM33_RS04710 ENOG4105CJ1 ABC, transporter FLM33_RS04730 ENOG4105DSJ YicC domain protein FLM33_RS04735 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) FLM33_RS04740 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FLM33_RS04750 ENOG4105EN6 Membrane FLM33_RS04755 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) FLM33_RS04760 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FLM33_RS04770 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FLM33_RS04775 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FLM33_RS04780 ENOG4105CB5 ATP-dependent DNA helicase recG FLM33_RS04785 ENOG4105CBT Fructose-1,6-bisphosphatase FLM33_RS04790 ENOG4105DP0 ferredoxin-NADP reductase FLM33_RS04795 ENOG4108VTS Membrane FLM33_RS04800 ENOG4105EBK exported protein FLM33_RS04805 ENOG4105CP7 Triose-phosphate isomerase FLM33_RS04820 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FLM33_RS04825 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FLM33_RS04830 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FLM33_RS04835 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FLM33_RS04840 ENOG4105D6U Sodium Glutamate Symporter FLM33_RS04845 ENOG4105C2W permease FLM33_RS04850 ENOG4105JV1 AsmA family FLM33_RS04855 ENOG4105CI1 PTS System FLM33_RS04860 ENOG4105F8D glycoside hydrolase family 4 FLM33_RS04870 ENOG4105CJQ hydrolase, family 31 FLM33_RS04875 ENOG4105CT4 transporter FLM33_RS04885 ENOG4105NI3 Protein of unknown function (DUF3237) FLM33_RS04905 ENOG4105DQ4 alcohol dehydrogenase FLM33_RS04915 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FLM33_RS04930 ENOG4105D01 (LipO)protein FLM33_RS04955 ENOG4105CR8 Transcriptional regulator FLM33_RS04965 ENOG410630P Transcriptional regulator FLM33_RS04985 ENOG4105C1P efflux transporter, rnd family, mfp subunit FLM33_RS04990 ENOG4105BZS acriflavin resistance protein FLM33_RS04995 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FLM33_RS05000 ENOG4105C2C drug resistance transporter, Bcr CflA FLM33_RS05005 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FLM33_RS05010 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) FLM33_RS05015 ENOG4108UZ3 Transporter FLM33_RS05020 ENOG4105T8A Uncharacterized protein YicS FLM33_RS05035 ENOG4105JSC dimethylmenaquinone methyltransferase FLM33_RS05045 ENOG4107F9Y LysR family transcriptional regulator FLM33_RS05055 ENOG4105D2S major facilitator superfamily FLM33_RS05060 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS05070 ENOG4105CK1 PTS System FLM33_RS05075 ENOG4105VCP PTS System FLM33_RS05080 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FLM33_RS05090 ENOG4108MP3 ABC transporter, permease FLM33_RS05105 ENOG4106S9K Transcriptional regulator FLM33_RS05110 ENOG4107STF Involved in phosphonate degradation (By similarity) FLM33_RS05115 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FLM33_RS05135 ENOG4108SAJ Protein of unknown function (DUF1198) FLM33_RS05140 ENOG4105CXY transporter FLM33_RS05145 ENOG4105CXY transporter FLM33_RS05150 ENOG4105BZU Histidine kinase FLM33_RS05155 ENOG4108KX4 response regulator FLM33_RS05160 ENOG4105M71 acetolactate synthase 1 regulatory subunit FLM33_RS05165 ENOG4105C7K acetolactate synthase FLM33_RS05195 ENOG4105E5M Multidrug resistance protein D FLM33_RS05200 ENOG4105W8I Transcriptional regulator FLM33_RS05225 ENOG4105JP4 Inner membrane protein yidG FLM33_RS05230 ENOG4105VG5 Membrane FLM33_RS05235 ENOG4105F8D glycoside hydrolase family 4 FLM33_RS05240 ENOG4105CI1 PTS System FLM33_RS05245 ENOG4105FDP GntR family transcriptional regulator FLM33_RS05250 ENOG4105D0C transport protein FLM33_RS05270 ENOG4105R2A (LipO)protein FLM33_RS05275 ENOG4105D99 atp gtp-binding protein FLM33_RS05280 ENOG4105DJB Major Facilitator Superfamily FLM33_RS05285 ENOG4105CXK mandelate racemase muconate lactonizing FLM33_RS05290 ENOG4108RTU Aldolase FLM33_RS05295 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FLM33_RS05300 ENOG4105EMF GntR family transcriptional regulator FLM33_RS05315 ENOG410667J hydrolase FLM33_RS05320 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLM33_RS05325 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FLM33_RS05330 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FLM33_RS05340 ENOG4105VG0 50S ribosomal protein l34 FLM33_RS05350 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FLM33_RS05355 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FLM33_RS05360 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FLM33_RS05370 ENOG4105C2C drug resistance transporter, Bcr CflA FLM33_RS05380 ENOG4105E8Q phosphopantetheinyl transferase FLM33_RS05385 ENOG4108YYH Nadph-dependent fmn reductase FLM33_RS05390 ENOG4105C7N Xanthine uracil vitamin C permease FLM33_RS05395 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FLM33_RS05400 ENOG4107VKM 6-phosphogluconolactonase FLM33_RS05405 ENOG4105DYC esterase FLM33_RS05420 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS05425 ENOG4105E2Z phosphate ABC transporter (Permease FLM33_RS05430 ENOG4105C8U phosphate abc transporter FLM33_RS05435 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FLM33_RS05440 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FLM33_RS05445 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FLM33_RS05450 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FLM33_RS05455 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FLM33_RS05460 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FLM33_RS05465 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FLM33_RS05470 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FLM33_RS05490 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FLM33_RS05495 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FLM33_RS05500 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FLM33_RS05505 ENOG4105QTB Flavodoxin FLM33_RS05510 ENOG4108VVK transcriptional Regulator, AsnC FLM33_RS05515 ENOG4105CU9 asparagine synthetase A FLM33_RS05530 ENOG4105DFH Transport of potassium into the cell (By similarity) FLM33_RS05540 ENOG4105C2J ABC transporter FLM33_RS05545 ENOG4105CNN ABC, transporter FLM33_RS05550 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FLM33_RS05555 ENOG4108RVA ribokinase FLM33_RS05560 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS05565 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLM33_RS05570 ENOG4107EJG GntR family transcriptional regulator FLM33_RS05595 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FLM33_RS05600 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FLM33_RS05605 ENOG4105PC1 Conserved Protein FLM33_RS05610 ENOG4105E27 serine threonine protein kinase FLM33_RS05615 ENOG4108Z33 Thiol disulfide Interchange Protein FLM33_RS05620 ENOG4106HNH Acyl-transferase FLM33_RS05625 ENOG4105C2M dna polymerase I FLM33_RS05630 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FLM33_RS05635 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FLM33_RS05640 ENOG4105D4P Coproporphyrinogen iii oxidase FLM33_RS05645 ENOG4106FIY FLM33_RS05650 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FLM33_RS05655 ENOG4105CUX Signal transduction histidine kinase FLM33_RS05660 ENOG4105C5F glutamine synthetase FLM33_RS05665 ENOG4105CI3 gtp-binding protein typa FLM33_RS05670 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FLM33_RS05675 ENOG4107S2Z UPF0761 membrane protein FLM33_RS05680 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FLM33_RS05685 ENOG4105SUU thioesterase domain FLM33_RS05695 ENOG41068KX affects formate dehydrogenase-N FLM33_RS05705 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) FLM33_RS05710 ENOG4108MG3 formate dehydrogenase FLM33_RS05715 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FLM33_RS05725 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FLM33_RS05735 ENOG4105CTQ phosphohexokinase FLM33_RS05750 ENOG4105D2N Aldolase FLM33_RS05795 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FLM33_RS05805 ENOG4105C0A alcohol dehydrogenase FLM33_RS05810 ENOG4105CNN ABC, transporter FLM33_RS05815 ENOG4105CNN ABC, transporter FLM33_RS05820 ENOG4105C2J ABC transporter FLM33_RS05825 ENOG4105D4B ABC, transporter FLM33_RS05830 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FLM33_RS05835 ENOG4105DKG l-rhamnose isomerase FLM33_RS05840 ENOG4105DET Rhamnulokinase FLM33_RS05845 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FLM33_RS05850 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FLM33_RS05855 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) FLM33_RS05860 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FLM33_RS05865 ENOG4108RPX mosc domain containing protein FLM33_RS05870 ENOG4105E0F Histidine kinase FLM33_RS05875 ENOG4105E3W Two component transcriptional regulator (Winged helix family FLM33_RS05880 ENOG4105FMW periplasmic FLM33_RS05885 ENOG41076HS cation diffusion facilitator family transporter FLM33_RS05890 ENOG4105CTQ phosphohexokinase FLM33_RS05895 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FLM33_RS05900 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FLM33_RS05910 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FLM33_RS05915 ENOG41063M6 Cell Division Protein FLM33_RS05920 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS05925 ENOG4105C25 Primosomal protein n' FLM33_RS05930 ENOG4105VFB Binds the 23S rRNA (By similarity) FLM33_RS05935 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FLM33_RS05940 ENOG4105C28 cystathionine FLM33_RS05945 ENOG4105CFH Aspartokinase FLM33_RS05955 ENOG4105CGH 5'-nucleotidase FLM33_RS05960 ENOG4108Z8I decarboxylase FLM33_RS05965 ENOG4105CN8 Transcriptional regulator FLM33_RS05970 ENOG4105SYT Methylenetetrahydrofolate reductase FLM33_RS05975 ENOG4108Q5Y Membrane FLM33_RS05980 ENOG4105DCT glycerol dehydrogenase FLM33_RS05985 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FLM33_RS05990 ENOG4106R3P AraC family transcriptional regulator FLM33_RS05995 ENOG4108MEK Metal-binding protein YodA FLM33_RS06010 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FLM33_RS06015 ENOG4105CAS nag kinase FLM33_RS06020 ENOG4105CH7 arginosuccinase FLM33_RS06025 ENOG4105C5Q Transcriptional regulator FLM33_RS06030 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FLM33_RS06035 ENOG4105EJ2 Transcriptional regulator FLM33_RS06040 ENOG4108Y73 Membrane FLM33_RS06045 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FLM33_RS06100 ENOG4108WFC UPF0438 protein yifE FLM33_RS06105 ENOG4105C0P Mg chelatase subunit ChlI FLM33_RS06120 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FLM33_RS06125 ENOG4105CM2 brancheD-chain amino acid aminotransferase FLM33_RS06130 ENOG4105C01 Dihydroxy-acid dehydratase FLM33_RS06135 ENOG4105C7B Threonine dehydratase FLM33_RS06140 ENOG4105EMY transcriptional regulator FLM33_RS06145 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FLM33_RS06150 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FLM33_RS06155 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FLM33_RS06160 ENOG4105C4R Atp-dependent dna helicase FLM33_RS06165 ENOG4108UQV Membrane FLM33_RS06175 ENOG4105C9X ppx gppa phosphatase FLM33_RS06180 ENOG4105C1J atp-dependent rna helicase FLM33_RS06190 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FLM33_RS06195 ENOG4105ESV Glycosyl transferase, family 4 FLM33_RS06200 ENOG4105SFE lipopolysaccharide biosynthesis protein FLM33_RS06205 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FLM33_RS06210 ENOG4107QQG Dehydrogenase FLM33_RS06215 ENOG4105C1B dTDP-glucose 4-6-dehydratase FLM33_RS06220 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FLM33_RS06225 ENOG4108WJ1 acetyltransferase FLM33_RS06230 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FLM33_RS06235 ENOG4105EGZ biosynthesis protein FLM33_RS06240 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) FLM33_RS06245 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) FLM33_RS06250 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FLM33_RS06255 ENOG4105C85 amino acid FLM33_RS06280 ENOG410601J HemY protein FLM33_RS06285 ENOG4105ECF c-methyltransferase FLM33_RS06290 ENOG41076E6 Uroporphyrinogen-III Synthase FLM33_RS06295 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FLM33_RS06300 ENOG4107T0K Adenylate cyclase FLM33_RS06305 ENOG4105XQ6 frataxin-like protein FLM33_RS06310 ENOG4105S7Z (LipO)protein FLM33_RS06320 ENOG4105CT0 Protein of unknown function, DUF484 FLM33_RS06325 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FLM33_RS06330 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FLM33_RS06335 ENOG4105C4R Atp-dependent dna helicase FLM33_RS06340 ENOG4107QUT magnesium and cobalt transport protein CorA FLM33_RS06345 ENOG4105FR1 rard protein FLM33_RS06350 ENOG4108VUY thioesterase Superfamily protein FLM33_RS06355 ENOG4105HDD phospholipase FLM33_RS06360 ENOG4105C9U ATP-dependent DNA helicase RecQ FLM33_RS06365 ENOG4105CCF Lysine exporter protein (Lyse ygga) FLM33_RS06375 ENOG410829K Lysine exporter protein (Lyse ygga) FLM33_RS06380 ENOG4108EUD Lysophospholipase FLM33_RS06385 ENOG4105DQF Hydrolase FLM33_RS06390 ENOG4105EMK carboxylate amino acid amine transporter FLM33_RS06395 ENOG4105DZ2 Transcriptional regulator FLM33_RS06400 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FLM33_RS06405 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FLM33_RS06410 ENOG4107SXA Phosphorylase FLM33_RS06415 ENOG4105CGY Dna recombination protein FLM33_RS06420 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FLM33_RS06425 ENOG4105JC1 sterol-binding domain protein FLM33_RS06430 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FLM33_RS06435 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FLM33_RS06440 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FLM33_RS06445 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FLM33_RS06455 ENOG4105MDZ Transcriptional activator rfaH FLM33_RS06460 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FLM33_RS06465 ENOG4107QK7 reductase FLM33_RS06470 ENOG4105CHU acetyl-coa acetyltransferase FLM33_RS06475 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) FLM33_RS06480 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) FLM33_RS06485 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FLM33_RS06490 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FLM33_RS06495 ENOG4108RR8 protoporphyrinogen oxidase FLM33_RS06525 ENOG4105D4A Cell wall formation (By similarity) FLM33_RS06530 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FLM33_RS06535 ENOG4105CS9 pantothenic acid kinase FLM33_RS06560 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FLM33_RS06565 ENOG4105PM1 preprotein translocase subunit SecE FLM33_RS06570 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FLM33_RS06575 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FLM33_RS06580 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FLM33_RS06585 ENOG4108VZM 50s ribosomal protein L10 FLM33_RS06590 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FLM33_RS06595 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLM33_RS06600 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLM33_RS06605 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FLM33_RS06610 ENOG4105VCP PTS System FLM33_RS06620 ENOG4106TD9 Diguanylate cyclase FLM33_RS06625 ENOG4105D41 biosynthesis protein thiH FLM33_RS06630 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FLM33_RS06635 ENOG4105WHD thiamine biosynthesis protein ThiS FLM33_RS06640 ENOG4105D06 uba thif-type nad fad binding protein FLM33_RS06645 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FLM33_RS06650 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FLM33_RS06655 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) FLM33_RS06660 ENOG4105E09 nadh pyrophosphatase FLM33_RS06665 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FLM33_RS06670 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FLM33_RS06675 ENOG4105R2J Conserved Protein FLM33_RS06680 ENOG4105K70 DNA-binding protein FLM33_RS06685 ENOG4108T8B Protein of unknown function (DUF1481) FLM33_RS06690 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism FLM33_RS06695 ENOG4105BZU Histidine kinase FLM33_RS06705 ENOG4105C12 Phosphoribosylglycinamide synthetase FLM33_RS06710 ENOG4105DC1 bifunctional purine biosynthesis protein purh FLM33_RS06735 ENOG4105K5X acetyltransferase FLM33_RS06740 ENOG4105CVG Homoserine O-transsuccinylase FLM33_RS06745 ENOG4107QP3 malate synthase g FLM33_RS06750 ENOG4108I9X Isocitrate lyase FLM33_RS06755 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FLM33_RS06760 ENOG41069M3 Transcriptional regulator FLM33_RS06765 ENOG4105C3R Methionine synthase FLM33_RS06770 ENOG4105EAM Na Pi-cotransporter FLM33_RS06775 ENOG4105F9E Shikimate 5-dehydrogenase FLM33_RS06780 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FLM33_RS06785 ENOG4105F3R pts system mannose fructose sorbose family iid FLM33_RS06790 ENOG4105ETZ PTS System FLM33_RS06795 ENOG4105KPI PTS system sorbose subfamily IIB component FLM33_RS06800 ENOG4108XCU pts system FLM33_RS06805 ENOG4105CHR reductase FLM33_RS06810 ENOG4105DKT Transcriptional regulator FLM33_RS06815 ENOG4105FE9 pseudouridine synthase FLM33_RS06820 ENOG4108ZR5 Conserved Protein FLM33_RS06825 ENOG4105C09 Bile acid FLM33_RS06830 ENOG4105CFH Aspartokinase FLM33_RS06835 ENOG4107QP8 phosphohexose isomerase FLM33_RS06840 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FLM33_RS06850 ENOG4105KME endoribonuclease L-psp FLM33_RS06865 ENOG4105CEM UPF0597 protein FLM33_RS06870 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FLM33_RS06875 ENOG4105EG2 ABC transporter, permease FLM33_RS06880 ENOG4105D56 permease protein FLM33_RS06885 ENOG4107FKK extracellular solute-binding protein family 1 FLM33_RS06890 ENOG4108IJ9 (ABC) transporter FLM33_RS06895 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FLM33_RS06900 ENOG4107W52 maltose operon periplasmic protein FLM33_RS06905 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FLM33_RS06910 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FLM33_RS06915 ENOG4105E55 glycerol-3-phosphate acyltransferase FLM33_RS06920 ENOG41080IJ Diacylglycerol kinase FLM33_RS06925 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FLM33_RS06930 ENOG4107R73 Mate efflux family protein FLM33_RS06940 ENOG4105VDW Csbd family FLM33_RS06945 ENOG4105MYN Zinc uptake regulation protein FLM33_RS06955 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FLM33_RS06960 ENOG4105P4Z Phage shock protein G FLM33_RS06965 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FLM33_RS06970 ENOG4105CDU Replicative dna helicase FLM33_RS06975 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FLM33_RS06980 ENOG4105CGF Aromatic amino acid aminotransferase FLM33_RS06990 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FLM33_RS06995 ENOG4105MSB protein, conserved in bacteria FLM33_RS07000 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FLM33_RS07005 ENOG4108UUM single-stranded DNA-binding protein FLM33_RS07010 ENOG4105E4C Lytic transglycosylase catalytic FLM33_RS07015 ENOG4107RNH Outer membrane receptor FepA FLM33_RS07020 ENOG4108DMH HTH_ARAC FLM33_RS07035 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FLM33_RS07045 ENOG4105ECY inositol monophosphatase FLM33_RS07050 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS07055 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FLM33_RS07080 ENOG4105PMV Membrane FLM33_RS07085 ENOG4108M8H domain protein FLM33_RS07090 ENOG4108W3Q Transcriptional regulator FLM33_RS07095 ENOG4108Z4X TRANSCRIPTIONal FLM33_RS07100 ENOG4108K3A Glutathione S-transferase FLM33_RS07105 ENOG4105C7N Xanthine uracil vitamin C permease FLM33_RS07110 ENOG4105EEQ Na H antiporter FLM33_RS07115 ENOG4105CMU LysR family (Transcriptional regulator FLM33_RS07125 ENOG41067MG lrgb family FLM33_RS07130 ENOG4105MX3 Fimbrial FLM33_RS07135 ENOG4108VCD Chaperone FLM33_RS07140 ENOG4105CW0 outer membrane usher protein FLM33_RS07155 ENOG4107QN1 sodium solute FLM33_RS07160 ENOG41062QD Membrane FLM33_RS07165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FLM33_RS07175 ENOG4105CK2 sodium dicarboxylate symporter FLM33_RS07180 ENOG41082ND Uncharacterized protein yjcO FLM33_RS07210 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FLM33_RS07215 ENOG4105CNN ABC, transporter FLM33_RS07220 ENOG4105C2J ABC transporter FLM33_RS07225 ENOG4105BZU Histidine kinase FLM33_RS07235 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FLM33_RS07240 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FLM33_RS07245 ENOG4105FD8 phosphonate metabolism protein PhnM FLM33_RS07250 ENOG4105HRV phosphonate c-p lyase system protein phnl FLM33_RS07255 ENOG4105ENV phosphonate C-P lyase system protein PhnK FLM33_RS07260 ENOG4105FT8 Phosphonate metabolism FLM33_RS07265 ENOG4105EKV Phosphonate metabolism protein FLM33_RS07270 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FLM33_RS07275 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FLM33_RS07280 ENOG4107RJJ Transcriptional regulator FLM33_RS07285 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FLM33_RS07290 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FLM33_RS07295 ENOG4105CSH Transporter FLM33_RS07300 ENOG4108K2B transcriptional regulator FLM33_RS07305 ENOG4105F8D glycoside hydrolase family 4 FLM33_RS07310 ENOG4105CT4 transporter FLM33_RS07340 ENOG4105DVC DnaJ domain protein FLM33_RS07350 ENOG4108ZCF integral membrane protein FLM33_RS07365 ENOG4105CND Glycosyl transferase, family 2 FLM33_RS07370 ENOG4107BJW polysaccharide deacetylase FLM33_RS07375 ENOG4108TUY outer membrane protein PgaA FLM33_RS07410 ENOG4108SIC Transcriptional regulator FLM33_RS07415 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FLM33_RS07425 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FLM33_RS07430 ENOG4108IJ0 Aspartate ammonia-lyase FLM33_RS07435 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FLM33_RS07440 ENOG4105DVH amino acid FLM33_RS07450 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FLM33_RS07455 ENOG4108ZVF (LipO)protein FLM33_RS07465 ENOG4108JJA ABC, transporter FLM33_RS07470 ENOG4108MBX Secretion Protein FLM33_RS07485 ENOG4105CW0 outer membrane usher protein FLM33_RS07505 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FLM33_RS07510 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FLM33_RS07520 ENOG4106BSU Entericidin B FLM33_RS07525 ENOG4105KPY Small multidrug resistance protein FLM33_RS07535 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FLM33_RS07545 ENOG4105E33 succinate dehydrogenase FLM33_RS07550 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FLM33_RS07555 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FLM33_RS07560 ENOG4107SC7 Inner membrane transporter yjeM FLM33_RS07565 ENOG4105EGS Mechanosensitive ion channel FLM33_RS07570 ENOG4105DJ4 phosphatidylserine decarboxylase FLM33_RS07575 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FLM33_RS07580 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FLM33_RS07585 ENOG4106TNF Periplasmic binding protein FLM33_RS07605 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FLM33_RS07610 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FLM33_RS07615 ENOG4105K8N protein family UPF0079, ATPase FLM33_RS07620 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLM33_RS07625 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FLM33_RS07630 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FLM33_RS07640 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FLM33_RS07645 ENOG4107QJR hflk protein FLM33_RS07650 ENOG4105EPW hflc protein FLM33_RS07665 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FLM33_RS07670 ENOG4105KPV Transcriptional regulator FLM33_RS07675 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FLM33_RS07680 ENOG4105C2N RNA methyltransferase TrmH family group 3 FLM33_RS07685 ENOG4105CSU acyl-Coa dehydrogenase FLM33_RS07690 ENOG4105S17 UPF0379 protein yjfN FLM33_RS07695 ENOG4105WSB biofilm stress and motility protein A FLM33_RS07700 ENOG4108MXZ Esterase FLM33_RS07715 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FLM33_RS07725 ENOG4106ETB IIa component FLM33_RS07750 ENOG4105KIT UPF0379 protein yjfY FLM33_RS07755 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FLM33_RS07760 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) FLM33_RS07765 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FLM33_RS07770 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FLM33_RS07775 ENOG4105FHY Opacity-associated protein A FLM33_RS07780 ENOG4108V1T peptidylprolyl cis-trans isomerase FLM33_RS07790 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FLM33_RS07795 ENOG4105DXC membrane FLM33_RS07805 ENOG4105ECR NmrA family FLM33_RS07810 ENOG4105KVH Transcriptional regulator FLM33_RS07815 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FLM33_RS07820 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FLM33_RS07825 ENOG4108UUE Transcriptional regulator FLM33_RS07830 ENOG41061GZ Protein of unknown function (DUF1107) FLM33_RS07840 ENOG4105C37 (CBS) domain FLM33_RS07850 ENOG4105CFU surface antigen FLM33_RS07855 ENOG4105MA0 exported protein FLM33_RS07860 ENOG4108ZHD aig2 family FLM33_RS07875 ENOG4105F0N pyrophosphate phospho-hydrolase FLM33_RS07880 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FLM33_RS07885 ENOG4105C2J ABC transporter FLM33_RS07890 ENOG4107R9N ABC transporter FLM33_RS07895 ENOG41062B0 ABC transporter, permease FLM33_RS07900 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FLM33_RS07905 ENOG4105DFU Cell wall formation (By similarity) FLM33_RS07925 ENOG4105N42 UPF0307 protein FLM33_RS07930 ENOG4105CMS peptidase U62, modulator of DNA gyrase FLM33_RS07935 ENOG4108XVM Cytochrome b(562) FLM33_RS07965 ENOG41069H0 dihydroorotase EC 3.5.2.3 FLM33_RS07980 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FLM33_RS07985 ENOG4105EMD TRANSCRIPTIONal FLM33_RS07995 ENOG4105K4U addiction module toxin, RelE StbE family FLM33_RS08000 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FLM33_RS08005 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FLM33_RS08025 ENOG4105F8D glycoside hydrolase family 4 FLM33_RS08030 ENOG4105CK1 PTS System FLM33_RS08035 ENOG4105CG3 alpha amylase, catalytic region FLM33_RS08040 ENOG4105C5Y PTS System FLM33_RS08045 ENOG4105D4X repressor FLM33_RS08055 ENOG4105KME endoribonuclease L-psp FLM33_RS08060 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FLM33_RS08065 ENOG4105CXT aspartate transcarbamylase FLM33_RS08075 ENOG4105XEP YhcH YjgK YiaL family protein FLM33_RS08080 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FLM33_RS08085 ENOG4108KPW sugar kinase FLM33_RS08090 ENOG4105CI2 imidazolone-5-propionate hydrolase FLM33_RS08095 ENOG4105CSX c4-dicarboxylate anaerobic carrier FLM33_RS08100 ENOG4105FDP GntR family transcriptional regulator FLM33_RS08110 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FLM33_RS08115 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FLM33_RS08120 ENOG4108MJ3 acetyltransferase FLM33_RS08125 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FLM33_RS08130 ENOG4105MYG DNA polymerase iii, chi subunit FLM33_RS08135 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FLM33_RS08140 ENOG4108M8S permease YjgP YjgQ family protein FLM33_RS08145 ENOG4108K5H permease YjgP YjgQ family protein FLM33_RS08150 ENOG4105D7A ATP-binding protein FLM33_RS08160 ENOG4105C26 Dehydrogenase FLM33_RS08165 ENOG4105DH8 myo-inositol catabolism FLM33_RS08170 ENOG4105CHC glucokinase (EC 2.7.1.2) FLM33_RS08175 ENOG4105D7K pfkb domain protein FLM33_RS08180 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FLM33_RS08190 ENOG4105F0H myo-inositol catabolism protein FLM33_RS08195 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FLM33_RS08210 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FLM33_RS08215 ENOG4105DRS transport system, permease FLM33_RS08225 ENOG4105DQ4 alcohol dehydrogenase FLM33_RS08230 ENOG4105CHH sulfate transporter FLM33_RS08235 ENOG41077A9 carbonic anhydrase FLM33_RS08260 ENOG4105DSG hydrolase family 43 FLM33_RS08265 ENOG4105CT4 transporter FLM33_RS08270 ENOG4105C93 Xylose Isomerase FLM33_RS08275 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FLM33_RS08280 ENOG4107SEY Conserved Protein FLM33_RS08300 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FLM33_RS08315 ENOG4107FW0 short-chain dehydrogenase reductase FLM33_RS08325 ENOG4108XDN Transcriptional regulator FLM33_RS08330 ENOG4105QNF Outer membrane lipoprotein FLM33_RS08340 ENOG4108IJF Heavy metal efflux pump, CzcA FLM33_RS08345 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FLM33_RS08350 ENOG410624V efflux system protein FLM33_RS08355 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FLM33_RS08360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLM33_RS08365 ENOG4105GR3 Histidine kinase FLM33_RS08380 ENOG4105EZE Cupin 4 family protein FLM33_RS08410 ENOG4105CMI transporter FLM33_RS08415 ENOG4105CJ1 ABC, transporter FLM33_RS08420 ENOG4105D0S secretion protein (HlyD FLM33_RS08445 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FLM33_RS08450 ENOG41064T2 transcriptional regulator, lysR family FLM33_RS08460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLM33_RS08465 ENOG4106DIZ Domain of unknown function (DUF1127) FLM33_RS08475 ENOG4105EFX secretion protein, HlyD family FLM33_RS08490 ENOG4105CIZ coA-substrate-specific enzyme activase FLM33_RS08495 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase FLM33_RS08505 ENOG41083G8 Multidrug resistance protein MdtM FLM33_RS08510 ENOG4106BRA Membrane FLM33_RS08520 ENOG4106AXJ AraC family transcriptional regulator FLM33_RS08525 ENOG4105DNE Transposase FLM33_RS08530 ENOG4105C26 Dehydrogenase FLM33_RS08540 ENOG4105CKI cobalamin synthesis protein FLM33_RS08545 ENOG4105VCD cytoplasmic protein FLM33_RS08550 ENOG4105D22 carbon starvation protein FLM33_RS08565 ENOG4107UWN reductase FLM33_RS08570 ENOG4105EFA 4-hydroxyphenylacetate FLM33_RS08575 ENOG4108NKV transcriptional regulator FLM33_RS08585 ENOG4105CNV Aldolase FLM33_RS08600 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase FLM33_RS08605 ENOG4105C26 Dehydrogenase FLM33_RS08615 ENOG4105ERH Fumarylacetoacetate hydrolase FLM33_RS08625 ENOG4108V8F Transcriptional regulator, MarR family FLM33_RS08635 ENOG4105DG4 malate L-lactate dehydrogenase FLM33_RS08665 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FLM33_RS08670 ENOG4108RTU Aldolase FLM33_RS08675 ENOG4106KNT transcriptional regulator FLM33_RS08680 ENOG4105XYF acetyltransferase FLM33_RS08690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FLM33_RS08700 ENOG4105KPI PTS system sorbose subfamily IIB component FLM33_RS08705 ENOG4105ETZ PTS System FLM33_RS08710 ENOG4105F3R pts system mannose fructose sorbose family iid FLM33_RS08720 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FLM33_RS08725 ENOG4105DNE Transposase FLM33_RS08735 ENOG4105RI1 glycoprotein receptor FLM33_RS08740 ENOG4106CVF DNA replication protein FLM33_RS08745 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) FLM33_RS08750 ENOG4107XM3 UPF0442 protein FLM33_RS08755 ENOG4105DWK Membrane FLM33_RS08760 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FLM33_RS08770 ENOG4108N8T regulatoR FLM33_RS08775 ENOG4108T94 DNA-binding transcriptional activator BglJ FLM33_RS08780 ENOG4108UIN ybak prolyl-trna synthetase associated region FLM33_RS08785 ENOG4105CK1 PTS System FLM33_RS08790 ENOG4108819 ferric iron reductase FLM33_RS08795 ENOG4106TD9 Diguanylate cyclase FLM33_RS08805 ENOG4105YBH Protein of unknown function (DUF1435) FLM33_RS08825 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FLM33_RS08830 ENOG4108WPU DNA polymerase III subunit psi FLM33_RS08835 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FLM33_RS08840 ENOG4105PAD Hydrolase FLM33_RS08845 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FLM33_RS08850 ENOG4105K3G Periplasmic Protein FLM33_RS08855 ENOG41075IC Protein of unknown function (DUF1328) FLM33_RS08860 ENOG4108NRW Phospholipase, patatin family FLM33_RS08865 ENOG4105EYA deoxyribonuclease FLM33_RS08870 ENOG4105D9N nucleoside FLM33_RS08880 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FLM33_RS08895 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FLM33_RS08900 ENOG41062Z9 Membrane FLM33_RS08905 ENOG4105EAC phosphoserine phosphatase FLM33_RS08910 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FLM33_RS08915 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FLM33_RS08920 ENOG4105C5H ABC transporter FLM33_RS08925 ENOG4107SC1 transglycosylase FLM33_RS08940 ENOG4105CVJ phosphoglycerate mutase FLM33_RS08945 ENOG4105UEI Transcriptional Regulator AraC Family FLM33_RS08950 ENOG4108RH0 Crea protein FLM33_RS08955 ENOG4105E3W Two component transcriptional regulator (Winged helix family FLM33_RS08960 ENOG4105EB3 Histidine kinase FLM33_RS08965 ENOG4105CT7 inner membrane cred family protein FLM33_RS08970 ENOG41065U4 response regulator FLM33_RS08975 ENOG410759A FLM33_RS08980 ENOG4106FVC RNA methyltransferase FLM33_RS08990 ENOG4105CFH Aspartokinase FLM33_RS08995 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FLM33_RS09000 ENOG4105D98 threonine synthase FLM33_RS09010 ENOG4105D1Q UPF0246 protein FLM33_RS09015 ENOG4105BZG amino acid carrier protein FLM33_RS09020 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FLM33_RS09025 ENOG4108RIR Molybdenum cofactor biosynthesis protein FLM33_RS09030 ENOG4105CSH Transporter FLM33_RS09035 ENOG4106HK8 GPR1 FUN34 yaaH family protein FLM33_RS09040 ENOG4108QUJ UPF0174 protein YaaW FLM33_RS09045 ENOG4108WTA UPF0412 protein YaaI FLM33_RS09050 ENOG4105CFG Acts as a chaperone (By similarity) FLM33_RS09055 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FLM33_RS09060 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FLM33_RS09065 ENOG41063Z6 transcriptional regulator, lysR family FLM33_RS09075 ENOG4105DTN riboflavin biosynthesis protein ribF FLM33_RS09085 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FLM33_RS09090 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FLM33_RS09095 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FLM33_RS09100 ENOG4105DU0 nucleoside hydrolase FLM33_RS09110 ENOG4105EXG Transcriptional regulator FLM33_RS09115 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FLM33_RS09120 ENOG4106YYS transcriptional regulatory protein FLM33_RS09125 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FLM33_RS09130 ENOG4105D9Q decarboxylase (Beta subunit) FLM33_RS09135 ENOG4107QSA Oxaloacetate decarboxylase FLM33_RS09145 ENOG4105D2K citrate carrier protein FLM33_RS09150 ENOG4105DUA (citrate (pro-3S)-lyase ligase FLM33_RS09155 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) FLM33_RS09160 ENOG4105CI0 Citrate lyase FLM33_RS09165 ENOG4105CHY citrate lyase, alpha FLM33_RS09170 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FLM33_RS09175 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FLM33_RS09180 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FLM33_RS09185 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FLM33_RS09190 ENOG4105M5B (LipO)protein FLM33_RS09200 ENOG4105CKD glutathione-regulated potassium-efflux system protein FLM33_RS09205 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FLM33_RS09210 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FLM33_RS09220 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FLM33_RS09225 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FLM33_RS09235 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FLM33_RS09240 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FLM33_RS09245 ENOG4106YYS transcriptional regulatory protein FLM33_RS09250 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FLM33_RS09255 ENOG4105D2K citrate carrier protein FLM33_RS09265 ENOG4105D3G Pseudouridine synthase FLM33_RS09270 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FLM33_RS09275 ENOG4105CQ2 DNA polymerase FLM33_RS09280 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FLM33_RS09285 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FLM33_RS09290 ENOG4105EF1 ribulokinase FLM33_RS09295 ENOG41063TF transcriptional regulator (AraC FLM33_RS09300 ENOG4108KF1 Membrane FLM33_RS09310 ENOG4106SMU thiamine transporter membrane protein FLM33_RS09330 ENOG4105S8Q sugar efflux transporter FLM33_RS09335 ENOG4105DJB Major Facilitator Superfamily FLM33_RS09340 ENOG4105C5Q Transcriptional regulator FLM33_RS09345 ENOG4105FF2 Type I DHQase FLM33_RS09350 ENOG4105EMV Major Facilitator FLM33_RS09365 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FLM33_RS09370 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FLM33_RS09380 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FLM33_RS09390 ENOG41064T2 transcriptional regulator, lysR family FLM33_RS09395 ENOG4105C7K acetolactate synthase FLM33_RS09400 ENOG4108ZP8 Acetolactate synthase small subunit FLM33_RS09405 ENOG4107B7Y DNA-binding transcriptional regulator FruR FLM33_RS09415 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FLM33_RS09420 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FLM33_RS09425 ENOG4105CJN penicillin-binding protein FLM33_RS09430 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FLM33_RS09435 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FLM33_RS09440 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FLM33_RS09450 ENOG4105CNI cell division protein FtsW FLM33_RS09455 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FLM33_RS09460 ENOG4105DFU Cell wall formation (By similarity) FLM33_RS09470 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FLM33_RS09475 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FLM33_RS09480 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FLM33_RS09485 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FLM33_RS09490 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) FLM33_RS09495 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FLM33_RS09500 ENOG4105M6F mutator MutT protein FLM33_RS09505 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FLM33_RS09510 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FLM33_RS09515 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FLM33_RS09520 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FLM33_RS09525 ENOG4105D7Q type ii secretion system FLM33_RS09530 ENOG4107QHF type ii secretion system protein e FLM33_RS09535 ENOG4108ZUW Major pilin subunit FLM33_RS09540 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FLM33_RS09545 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FLM33_RS09550 ENOG4106A72 regulatory protein AmpE FLM33_RS09555 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) FLM33_RS09560 ENOG4105CT4 transporter FLM33_RS09565 ENOG4105C85 amino acid FLM33_RS09570 ENOG41073TP transcriptional regulator FLM33_RS09575 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FLM33_RS09580 ENOG4107QSN dihydrolipoamide acetyltransferase FLM33_RS09585 ENOG4107QN2 dihydrolipoyl dehydrogenase FLM33_RS09600 ENOG4108NST exported protein FLM33_RS09605 ENOG4107QIJ Aconitate hydratase 2 FLM33_RS09610 ENOG4108ZIG UPF0231 protein FLM33_RS09615 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FLM33_RS09620 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FLM33_RS09645 ENOG4108ZRK uncharacterized protein yacC FLM33_RS09650 ENOG4105E3B Multicopper oxidase FLM33_RS09655 ENOG4105DZG Dehydrogenase FLM33_RS09665 ENOG4108UGV hypoxanthine phosphoribosyltransferase FLM33_RS09670 ENOG41077A9 carbonic anhydrase FLM33_RS09675 ENOG4105DA5 (ABC) transporter FLM33_RS09680 ENOG4105E3A (ABC) transporter FLM33_RS09685 ENOG4108YTN IIa component FLM33_RS09690 ENOG4107BJW polysaccharide deacetylase FLM33_RS09695 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FLM33_RS09700 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FLM33_RS09705 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FLM33_RS09710 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FLM33_RS09715 ENOG4105DJ0 Poly(A) Polymerase FLM33_RS09720 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FLM33_RS09725 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FLM33_RS09730 ENOG4105PW4 Sugar fermentation stimulation protein homolog FLM33_RS09735 ENOG4107XID 2'-5' rna ligase FLM33_RS09740 ENOG4105CQ7 ATP-dependent helicase FLM33_RS09835 ENOG4105BZ4 penicillin-binding protein FLM33_RS09840 ENOG4105E0K tonB-dependent siderophore receptor FLM33_RS09845 ENOG4105E0A ABC, transporter FLM33_RS09850 ENOG4105J76 Periplasmic binding protein FLM33_RS09855 ENOG4105S6R Iron-hydroxamate transporter permease subunit FLM33_RS09860 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FLM33_RS09865 ENOG4105CMQ Chloride channel FLM33_RS09870 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FLM33_RS09875 ENOG4105EN6 Membrane FLM33_RS09880 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FLM33_RS09885 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FLM33_RS09890 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FLM33_RS09895 ENOG4105C0H protease FLM33_RS09900 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FLM33_RS09905 ENOG4108T8E UPF0325 protein FLM33_RS09910 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FLM33_RS09915 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FLM33_RS09920 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FLM33_RS09925 ENOG4105CE9 30S ribosomal protein S2 FLM33_RS09930 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FLM33_RS09935 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FLM33_RS09945 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FLM33_RS09955 ENOG4105KNE Phosphatidate cytidylyltransferase FLM33_RS09960 ENOG4105DZP Membrane-associated zinc metalloprotease FLM33_RS09965 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FLM33_RS09970 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FLM33_RS09975 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FLM33_RS09980 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FLM33_RS09985 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FLM33_RS09990 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FLM33_RS09995 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FLM33_RS10000 ENOG4105C0B DNA polymerase III (alpha subunit) FLM33_RS10005 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FLM33_RS10010 ENOG4105CXN decarboxylase FLM33_RS10015 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FLM33_RS10020 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FLM33_RS10025 ENOG4105M1T rho-binding antiterminator FLM33_RS10030 ENOG4105W1I UPF0253 protein FLM33_RS10035 ENOG4108VWS Yaeq family FLM33_RS10040 ENOG4108YZN class I peptide chain release factor FLM33_RS10045 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FLM33_RS10050 ENOG4108UY0 (LipO)protein FLM33_RS10055 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FLM33_RS10060 ENOG4108R96 Methyltransferase, YaeB family FLM33_RS10065 ENOG4108R8X outer membrane lipoprotein FLM33_RS10070 ENOG4105D01 (LipO)protein FLM33_RS10075 ENOG4108UMI ABC transporter, permease FLM33_RS10080 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS10085 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FLM33_RS10120 ENOG4105CV8 reductase FLM33_RS10125 ENOG4105HEI LysR family (Transcriptional regulator FLM33_RS10130 ENOG4105F27 Major Facilitator FLM33_RS10140 ENOG4105F2W methyltransferase FLM33_RS10145 ENOG4105E9H Lytic Murein transglycosylase FLM33_RS10150 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FLM33_RS10155 ENOG4105D1A Methyltransferase FLM33_RS10160 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FLM33_RS10165 ENOG4107RZZ dna polymerase iii epsilon subunit FLM33_RS10175 ENOG41090KR LysR family transcriptional Regulator FLM33_RS10180 ENOG4108VP3 Lysine exporter protein (LysE YggA) FLM33_RS10185 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FLM33_RS10190 ENOG4107QPN acyl-Coa dehydrogenase FLM33_RS10195 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FLM33_RS10200 ENOG4105E7A Glutamine amidotransferase FLM33_RS10205 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FLM33_RS10210 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FLM33_RS10215 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FLM33_RS10220 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FLM33_RS10225 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FLM33_RS10230 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FLM33_RS10235 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FLM33_RS10250 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FLM33_RS10255 ENOG4108HYG acetyltransferase FLM33_RS10260 ENOG4105CIN aminoacyl-histidine dipeptidase FLM33_RS10265 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FLM33_RS10270 ENOG4105V1F Fermentation respiration switch protein FLM33_RS10275 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FLM33_RS10280 ENOG4108PVQ transcriptional regulator FLM33_RS10285 ENOG4105C85 amino acid FLM33_RS10290 ENOG4108JPW Aminotransferase FLM33_RS10295 ENOG4105C26 Dehydrogenase FLM33_RS10300 ENOG4105D5U fad dependent oxidoreductase FLM33_RS10310 ENOG4105YCT UPF0386 protein FLM33_RS10315 ENOG4105DTA methyltransferase FLM33_RS10325 ENOG4105DT3 PTS system, galactitol-specific IIc component FLM33_RS10330 ENOG4108JQ1 Dehydrogenase FLM33_RS10335 ENOG4105CHR reductase FLM33_RS10340 ENOG4105CMG Carbohydrate kinase FLM33_RS10350 ENOG41061GT Aldolase FLM33_RS10360 ENOG4107QN2 dihydrolipoyl dehydrogenase FLM33_RS10370 ENOG4105CPP Dehydrogenase, E1 component FLM33_RS10375 ENOG4107R0V Pyruvate dehydrogenase FLM33_RS10380 ENOG41061ZR Transcriptional regulator FLM33_RS10415 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FLM33_RS10420 ENOG4105FCK Membrane FLM33_RS10425 ENOG4108QBX (LipO)protein FLM33_RS10445 ENOG4105S7S phosphonate abc transporter FLM33_RS10455 ENOG4105EHI Phosphonate ABC transporter, periplasmic FLM33_RS10465 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon FLM33_RS10470 ENOG4108GWT fimbrillin MatB FLM33_RS10475 ENOG4108NN8 Fimbrial protein FLM33_RS10480 ENOG4108N3D putative enzyme FLM33_RS10485 ENOG4106PYX Receptor FLM33_RS10495 ENOG4105DRP amino acid AbC transporter FLM33_RS10500 ENOG4105EZ7 amino acid ABC transporter FLM33_RS10505 ENOG4105CDA abc transporter atp-binding protein FLM33_RS10510 ENOG4105CT1 (ABC) transporter FLM33_RS10520 ENOG4108IV0 ABC, transporter FLM33_RS10525 ENOG4105C0Z ABC transporter FLM33_RS10530 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FLM33_RS10535 ENOG4105C32 Amino acid ABC transporter (Permease) FLM33_RS10550 ENOG4107FQ9 ethanolamine ammonia-lyase FLM33_RS10555 ENOG4105CPD ethanolamine ammonia-lyase FLM33_RS10560 ENOG4105C85 amino acid FLM33_RS10570 ENOG4108IQI permease FLM33_RS10575 ENOG4107QK5 Homocysteine s-methyltransferase FLM33_RS10580 ENOG4106FTQ Taurine ABC transporter, periplasmic FLM33_RS10585 ENOG4108ETV ABC transporter FLM33_RS10590 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FLM33_RS10595 ENOG4105E2B Taurine dioxygenase FLM33_RS10605 ENOG4105D52 delta-aminolevulinic acid dehydratase FLM33_RS10610 ENOG4107R6D beta-lactam binding protein AmpH FLM33_RS10615 ENOG4108RWI nicotinamidase FLM33_RS10620 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 FLM33_RS10625 ENOG4107QS8 (LipO)protein FLM33_RS10630 ENOG4105FR5 inner membrane protein YaiY FLM33_RS10635 ENOG4105UNH Membrane FLM33_RS10640 ENOG4105CPF Cell wall formation (By similarity) FLM33_RS10660 ENOG4105G6Z alkaline phosphatase FLM33_RS10665 ENOG4105VIF phosphate starvation-inducible protein FLM33_RS10670 ENOG4105II7 pyrroline-5-carboxylate reductase FLM33_RS10675 ENOG4108UPT UPF0178 protein FLM33_RS10680 ENOG4105G4C Periplasmic ligand-binding sensor protein FLM33_RS10685 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FLM33_RS10690 ENOG4105SS3 FLM33_RS10695 ENOG4105HBA AroM protein FLM33_RS10700 ENOG4105NBK UPF0345 protein FLM33_RS10705 ENOG4105DH7 May be involved in recombination (By similarity) FLM33_RS10710 ENOG4105DKQ ROK family FLM33_RS10715 ENOG4105EYH Exonuclease FLM33_RS10720 ENOG4107RH8 nuclease SbcCD subunit D FLM33_RS10725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLM33_RS10730 ENOG4105BZU Histidine kinase FLM33_RS10735 ENOG4105CWM branched-chain amino acid transport system II carrier protein FLM33_RS10740 ENOG4105C85 amino acid FLM33_RS10745 ENOG4107R28 alpha amylase, catalytic region FLM33_RS10750 ENOG4105EQ1 Transcriptional regulator FLM33_RS10755 ENOG4105CHJ isochorismatase hydrolase FLM33_RS10765 ENOG4105CI2 imidazolone-5-propionate hydrolase FLM33_RS10775 ENOG4108MGF sugar kinase FLM33_RS10790 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FLM33_RS10800 ENOG4105D3R alkyl hydroperoxide reductase FLM33_RS10805 ENOG4108ZYK Acyl carrier protein phosphodiesterase FLM33_RS10815 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FLM33_RS10820 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FLM33_RS10825 ENOG4105VIE preprotein translocase, subunit YajC FLM33_RS10830 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FLM33_RS10835 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FLM33_RS10850 ENOG4105DRB nucleoside-specific channel-forming protein FLM33_RS10855 ENOG4108KIC (LipO)protein FLM33_RS10860 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FLM33_RS10865 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FLM33_RS10870 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FLM33_RS10875 ENOG4107YIM Involved in the transcription termination process (By similarity) FLM33_RS10880 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FLM33_RS10885 ENOG4108ZAI phosphatidylglycerophosphatase a FLM33_RS10890 ENOG4105CPC Aldo Keto reductase FLM33_RS10895 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FLM33_RS10900 ENOG4105CTB Polyprenyl synthetase FLM33_RS10905 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FLM33_RS10910 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FLM33_RS10920 ENOG4107S0N DJ-1 family FLM33_RS10925 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FLM33_RS10935 ENOG4107RDB Major Facilitator FLM33_RS10940 ENOG4105CIB oxidoreductase Domain protein FLM33_RS10945 ENOG4105D2S major facilitator superfamily FLM33_RS10955 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FLM33_RS10965 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FLM33_RS10970 ENOG4105E2X shikimate dehydrogenase FLM33_RS10975 ENOG4107HP6 Transcriptional regulator FLM33_RS10985 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FLM33_RS10990 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FLM33_RS10995 ENOG4105CCU oxidase (Subunit III) FLM33_RS11000 ENOG4105BZ9 Cytochrome C oxidase, subunit I FLM33_RS11005 ENOG4105E2S oxidase) subunit II FLM33_RS11010 ENOG4105EYM Major Facilitator superfamily FLM33_RS11015 ENOG4105IEY (LipO)protein FLM33_RS11020 ENOG4105M85 Bola protein FLM33_RS11025 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FLM33_RS11035 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FLM33_RS11040 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FLM33_RS11045 ENOG4105K70 DNA-binding protein FLM33_RS11050 ENOG4105EIN peptidylprolyl cis-trans isomerase FLM33_RS11055 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FLM33_RS11060 ENOG4108TGP Thioesterase superfamily protein FLM33_RS11065 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FLM33_RS11070 ENOG4108NFA extracellular solute-binding protein FLM33_RS11075 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) FLM33_RS11085 ENOG4108XM1 transcriptional regulator AsnC family FLM33_RS11090 ENOG4105BZ1 (ABC) transporter FLM33_RS11095 ENOG4105BZ1 (ABC) transporter FLM33_RS11100 ENOG4108YZA Nitrogen regulatory protein pii FLM33_RS11105 ENOG4105BZU Histidine kinase FLM33_RS11110 ENOG4105C29 acyl-CoA thioesterase FLM33_RS11115 ENOG4108MNP Glycoprotein polysaccharide metabolism FLM33_RS11120 ENOG41080UX Methyltransferase FLM33_RS11150 ENOG4108VW9 Membrane FLM33_RS11155 ENOG41061MD high-affinity nickel-transporter FLM33_RS11160 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter FLM33_RS11165 ENOG41066DG (EAL) domain protein FLM33_RS11175 ENOG4107FKK extracellular solute-binding protein family 1 FLM33_RS11185 ENOG4105EG2 ABC transporter, permease FLM33_RS11195 ENOG4105C4C beta-galactosidase FLM33_RS11200 ENOG4105CI1 PTS System FLM33_RS11205 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FLM33_RS11210 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS11220 ENOG4105YK5 50S ribosomal protein L36 FLM33_RS11235 ENOG4105GSJ Inner membrane protein ylaC FLM33_RS11245 ENOG4108UW5 maltose o-acetyltransferase FLM33_RS11255 ENOG4108UKR Biofilm formation regulator YbaJ FLM33_RS11260 ENOG4105BZS acriflavin resistance protein FLM33_RS11265 ENOG4105C1P efflux transporter, rnd family, mfp subunit FLM33_RS11270 ENOG4107XI7 Tetr family transcriptional regulator FLM33_RS11275 ENOG4105EGS Mechanosensitive ion channel FLM33_RS11280 ENOG4105DNE Transposase FLM33_RS11285 ENOG4106428 Protein of unknown function (DUF2496) FLM33_RS11290 ENOG4108URS primosomal replication protein n'' FLM33_RS11295 ENOG4105WD1 Membrane FLM33_RS11300 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FLM33_RS11305 ENOG4107QMP dna polymerase iii subunits gamma and tau FLM33_RS11310 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FLM33_RS11315 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FLM33_RS11320 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FLM33_RS11325 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FLM33_RS11335 ENOG4107RE1 Inosine-guanosine kinase FLM33_RS11340 ENOG4105CKD glutathione-regulated potassium-efflux system protein FLM33_RS11345 ENOG4105EU0 Major facilitator Superfamily FLM33_RS11350 ENOG4105CGH 5'-nucleotidase FLM33_RS11355 ENOG4108Z66 YbaK ebsC protein FLM33_RS11360 ENOG4105MBR gumn family FLM33_RS11365 ENOG4105C59 p-type ATPase FLM33_RS11370 ENOG4108Z6Z Transcriptional regulator FLM33_RS11375 ENOG4105G5H Membrane FLM33_RS11380 ENOG4107QX8 SPFH domain, Band 7 family protein FLM33_RS11385 ENOG41083J0 (ABC) transporter FLM33_RS11390 ENOG4105C4B ABC transporter, permease FLM33_RS11395 ENOG4107QR8 Thioredoxin FLM33_RS11400 ENOG4105E1F short-chain dehydrogenase reductase FLM33_RS11405 ENOG4108UJV acyl-CoA thioesterase i FLM33_RS11410 ENOG4108I0Y (ABC) transporter FLM33_RS11415 ENOG4105CV6 ABC transporter, permease FLM33_RS11435 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FLM33_RS11440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FLM33_RS11450 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FLM33_RS11455 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FLM33_RS11460 ENOG4105C8N cysteinyl-tRNA synthetase FLM33_RS11465 ENOG4105WQ3 Rna-binding protein FLM33_RS11470 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FLM33_RS11555 ENOG4105BZN citrate synthase FLM33_RS11570 ENOG4105X0I Fimbrial FLM33_RS11575 ENOG4105GQR Chaperone FLM33_RS11580 ENOG4105CW0 outer membrane usher protein FLM33_RS11595 ENOG4105D1S lipid A biosynthesis FLM33_RS11605 ENOG4108M3R transcriptional activator CadC FLM33_RS11610 ENOG4105D5Q Arginine ornithine antiporter FLM33_RS11615 ENOG4105CXN decarboxylase FLM33_RS11620 ENOG4105DUX Transporter FLM33_RS11625 ENOG4105CRK lysyL-tRNA synthetase FLM33_RS11665 ENOG4105C2J ABC transporter FLM33_RS11670 ENOG4108HWV )-transporter FLM33_RS11680 ENOG4105WBN Transcriptional regulator (LacI family FLM33_RS11685 ENOG4108HKT sucrose-6-phosphate hydrolase FLM33_RS11690 ENOG4105C5Y PTS System FLM33_RS11695 ENOG4108M0B Sucrose porin FLM33_RS11700 ENOG4105D7K pfkb domain protein FLM33_RS11710 ENOG4105KK7 inner membrane protein YiaW FLM33_RS11715 ENOG4105EFX secretion protein, HlyD family FLM33_RS11720 ENOG4105E0A ABC, transporter FLM33_RS11725 ENOG4105EHG Permease protein FLM33_RS11755 ENOG4105CH2 amidohydrolase FLM33_RS11760 ENOG4105E89 ABC transporter FLM33_RS11765 ENOG4105CPC Aldo Keto reductase FLM33_RS11780 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FLM33_RS11790 ENOG4108UAJ Transcriptional regulator FLM33_RS11800 ENOG4105DGU Histone deacetylase FLM33_RS11810 ENOG4105CUB amino acid FLM33_RS11820 ENOG4105CJP fad dependent oxidoreductase FLM33_RS11825 ENOG4105C26 Dehydrogenase FLM33_RS11830 ENOG4108NS2 receptor FLM33_RS11840 ENOG4105C85 amino acid FLM33_RS11845 ENOG4105EAA nucleoside FLM33_RS11855 ENOG4105CK5 oxidoreductase FLM33_RS11885 ENOG4105CUY Mechanosensitive ion channel FLM33_RS11905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FLM33_RS11910 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FLM33_RS11915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FLM33_RS11920 ENOG4105F3R pts system mannose fructose sorbose family iid FLM33_RS11930 ENOG4108IQ3 PTS system FLM33_RS11940 ENOG4108RCM Nitroreductase FLM33_RS11945 ENOG4105MSB protein, conserved in bacteria FLM33_RS11965 ENOG4105HFT AraC family transcriptional regulator FLM33_RS11970 ENOG4105WQ6 Membrane FLM33_RS11995 ENOG4108T58 Mg2 transport protein CorA FLM33_RS12000 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FLM33_RS12005 ENOG4105T38 integral membrane protein FLM33_RS12010 ENOG4105CHM Aminotransferase FLM33_RS12020 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FLM33_RS12025 ENOG4105E5Q amino acid AbC transporter FLM33_RS12030 ENOG4105GBT ABC transporter FLM33_RS12040 ENOG4105EMU Dehydrogenase FLM33_RS12045 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FLM33_RS12050 ENOG4108JQ7 (ABC) transporter FLM33_RS12055 ENOG4105C3U ABC transporter FLM33_RS12060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLM33_RS12065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLM33_RS12070 ENOG4105DEF Extracellular solute-binding protein, family 5 FLM33_RS12080 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FLM33_RS12095 ENOG4105C94 Transporter FLM33_RS12100 ENOG4108WN0 inhibitor of vertebrate lysozyme FLM33_RS12105 ENOG4105CUY Mechanosensitive ion channel FLM33_RS12110 ENOG410810E transcriptional regulator, lysR family FLM33_RS12120 ENOG4108R85 Short chain dehydrogenase FLM33_RS12130 ENOG4105CNN ABC, transporter FLM33_RS12135 ENOG4105C2J ABC transporter FLM33_RS12145 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FLM33_RS12155 ENOG4105DKT Transcriptional regulator FLM33_RS12160 ENOG4108HHA Transketolase FLM33_RS12165 ENOG4108IUS Transketolase FLM33_RS12170 ENOG4108TSE Transferase FLM33_RS12175 ENOG4107RNH Outer membrane receptor FepA FLM33_RS12180 ENOG4105E93 esterase FLM33_RS12185 ENOG41085A6 mbth domain-containing protein FLM33_RS12190 ENOG4105C0W non-ribosomal peptide synthetase FLM33_RS12195 ENOG4105E0A ABC, transporter FLM33_RS12200 ENOG4105TVJ transport system, permease FLM33_RS12205 ENOG4105DQ5 transport system permease protein FLM33_RS12210 ENOG4105E8G Major facilitator Superfamily FLM33_RS12215 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FLM33_RS12220 ENOG4105E4F Isochorismate synthase FLM33_RS12225 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FLM33_RS12230 ENOG4105WQI isochorismatase FLM33_RS12235 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FLM33_RS12240 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FLM33_RS12245 ENOG4105D22 carbon starvation protein FLM33_RS12250 ENOG4105VCD cytoplasmic protein FLM33_RS12265 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FLM33_RS12270 ENOG4107SCQ Iron-containing alcohol dehydrogenase FLM33_RS12275 ENOG4105C2J ABC transporter FLM33_RS12280 ENOG4105CNN ABC, transporter FLM33_RS12295 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FLM33_RS12300 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FLM33_RS12305 ENOG4105D6F Phosphatase FLM33_RS12310 ENOG4105CXY transporter FLM33_RS12315 ENOG4105ECY inositol monophosphatase FLM33_RS12325 ENOG4105DZC cytosine deaminase FLM33_RS12335 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FLM33_RS12340 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FLM33_RS12350 ENOG4108M3J Dehydrogenase FLM33_RS12360 ENOG4105CNN ABC, transporter FLM33_RS12365 ENOG4105CNN ABC, transporter FLM33_RS12370 ENOG4105C2J ABC transporter FLM33_RS12385 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FLM33_RS12390 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FLM33_RS12395 ENOG4105CHM Aminotransferase FLM33_RS12400 ENOG4105GTN ParB Domain Protein Nuclease FLM33_RS12405 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FLM33_RS12410 ENOG4105DQS Transcriptional regulator FLM33_RS12415 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FLM33_RS12420 ENOG4105D3R alkyl hydroperoxide reductase FLM33_RS12425 ENOG4108JU3 Alkyl hydroperoxide reductase FLM33_RS12430 ENOG4108U51 Universal stress protein FLM33_RS12435 ENOG4105NXH GreA GreB family elongation factor FLM33_RS12440 ENOG4105KTS ribonuclease FLM33_RS12445 ENOG4105CEE C4-dicarboxylate transporter FLM33_RS12450 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FLM33_RS12470 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FLM33_RS12475 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FLM33_RS12480 ENOG41064T2 transcriptional regulator, lysR family FLM33_RS12485 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FLM33_RS12490 ENOG4108Z43 UPF0250 protein FLM33_RS12495 ENOG4105DZ1 carboxypeptidase FLM33_RS12500 ENOG4105K6T rare lipoprotein A FLM33_RS12505 ENOG4105CNI cell division protein FtsW FLM33_RS12510 ENOG4105CJN penicillin-binding protein FLM33_RS12515 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FLM33_RS12520 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FLM33_RS12525 ENOG4108TGR phosphatase FLM33_RS12530 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FLM33_RS12535 ENOG4105DJF DNA polymerase III, delta' subunit FLM33_RS12545 ENOG4105C8T Leucyl-tRNA synthetase FLM33_RS12550 ENOG4107PAI alpha helical protein FLM33_RS12565 ENOG4105CDA abc transporter atp-binding protein FLM33_RS12570 ENOG4105DRP amino acid AbC transporter FLM33_RS12575 ENOG4105EAD ABC transporter FLM33_RS12580 ENOG4107RP9 extracellular solute-binding protein, family 3 FLM33_RS12585 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FLM33_RS12590 ENOG4108JU5 Magnesium and cobalt efflux protein FLM33_RS12595 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FLM33_RS12600 ENOG4105C9A Phoh family FLM33_RS12605 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FLM33_RS12610 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FLM33_RS12650 ENOG4105CAQ asparagine synthetase FLM33_RS12655 ENOG4105D4U had-superfamily hydrolase, subfamily iia FLM33_RS12660 ENOG4105E2R ROK family FLM33_RS12665 ENOG4105CE4 GlcNAc 6-P deacetylase FLM33_RS12670 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FLM33_RS12675 ENOG4105CI1 PTS System FLM33_RS12680 ENOG4105CX6 glutaminyL-tRNA synthetase FLM33_RS12690 ENOG4105J5J Outer membrane porin FLM33_RS12695 ENOG4105GX6 (LipO)protein FLM33_RS12700 ENOG4105CSH Transporter FLM33_RS12705 ENOG41090R7 Ferric uptake FLM33_RS12710 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FLM33_RS12715 ENOG4105NNH LexA regulated protein FLM33_RS12720 ENOG4105EV9 Alpha Beta Hydrolase FLM33_RS12725 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FLM33_RS12730 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FLM33_RS12740 ENOG4105EEX Two component transcriptional regulator (Winged helix family FLM33_RS12745 ENOG4105C08 Histidine kinase FLM33_RS12750 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FLM33_RS12755 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FLM33_RS12760 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FLM33_RS12770 ENOG4105XIQ Protein of unknown function (DUF2517) FLM33_RS12775 ENOG4105CVP deoxyribo-dipyrimidine photolyase FLM33_RS12780 ENOG4105DUX Transporter FLM33_RS12785 ENOG4107QNR UPF0135 protein FLM33_RS12790 ENOG4105P4J Allophanate hydrolase, subunit 1 FLM33_RS12795 ENOG4107R7A Allophanate hydrolase subunit 2 FLM33_RS12800 ENOG4105E7W lamb ycsf family protein FLM33_RS12820 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FLM33_RS12825 ENOG4105BZN citrate synthase FLM33_RS12830 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FLM33_RS12835 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FLM33_RS12840 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FLM33_RS12845 ENOG4105E33 succinate dehydrogenase FLM33_RS12850 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FLM33_RS12855 ENOG4105C7S Dehydrogenase FLM33_RS12860 ENOG4105CMV Succinyl-CoA synthetase subunit beta FLM33_RS12865 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FLM33_RS12870 ENOG4105C4M (Ubiquinol oxidase) subunit I FLM33_RS12875 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FLM33_RS12885 ENOG4105KJB cyd operon protein YbgE FLM33_RS12890 ENOG4107YD3 Thioesterase FLM33_RS12895 ENOG4105E02 MotA TolQ exbB proton channel FLM33_RS12905 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FLM33_RS12905 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FLM33_RS12915 ENOG4105KCK Peptidoglycan-associated lipoprotein FLM33_RS12920 ENOG4105UFD tol-pal system protein YbgF FLM33_RS12965 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FLM33_RS12970 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FLM33_RS12975 ENOG4105PGM cation diffusion facilitator family transporter FLM33_RS12980 ENOG4105JND homeobox protein FLM33_RS12985 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FLM33_RS12990 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FLM33_RS12995 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FLM33_RS13000 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FLM33_RS13005 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FLM33_RS13010 ENOG4105CMR udp-glucose 4-epimerase FLM33_RS13015 ENOG4105DKW ABC transporter FLM33_RS13020 ENOG4105F4R Transcriptional regulator mode FLM33_RS13030 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FLM33_RS13035 ENOG4105E0C molybdate abc transporter FLM33_RS13045 ENOG4108K4B hydrolase FLM33_RS13050 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FLM33_RS13065 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FLM33_RS13070 ENOG4105BZU Histidine kinase FLM33_RS13075 ENOG4108XDN Transcriptional regulator FLM33_RS13110 ENOG4105NBR Pectinesterase FLM33_RS13115 ENOG4105CI2 imidazolone-5-propionate hydrolase FLM33_RS13120 ENOG41088SP formiminoglutamate hydrolase FLM33_RS13135 ENOG4105CGP Urocanate hydratase FLM33_RS13140 ENOG4105C84 Histidine ammonia-lyase FLM33_RS13145 ENOG4105C85 amino acid FLM33_RS13150 ENOG4108V1U phospholipid-binding protein FLM33_RS13155 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FLM33_RS13160 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FLM33_RS13165 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FLM33_RS13170 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FLM33_RS13180 ENOG4108IV0 ABC, transporter FLM33_RS13190 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FLM33_RS13195 ENOG4105ECM Sensor protein basS pmrB FLM33_RS13200 ENOG4105XJC Two component transcriptional regulator (Winged helix family FLM33_RS13205 ENOG4105DIJ Phosphoethanolamine transferase FLM33_RS13210 ENOG4105CHW UPF0052 protein FLM33_RS13215 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FLM33_RS13220 ENOG4108RIR Molybdenum cofactor biosynthesis protein FLM33_RS13225 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FLM33_RS13230 ENOG4105M00 molybdopterin converting factor, subunit 1 FLM33_RS13235 ENOG4108ZAF Molybdopterin FLM33_RS13240 ENOG4105HFZ Membrane FLM33_RS13245 ENOG4107UXM Membrane FLM33_RS13250 ENOG4105DZQ phospholipase D Transphosphatidylase FLM33_RS13255 ENOG4105X23 Endonuclease Exonuclease phosphatase FLM33_RS13260 ENOG4105I9U inner membrane protein ybhQ FLM33_RS13265 ENOG4107QWP ABC-2 type transporter FLM33_RS13270 ENOG4107QWP ABC-2 type transporter FLM33_RS13275 ENOG4105CJ1 ABC, transporter FLM33_RS13280 ENOG4105D0S secretion protein (HlyD FLM33_RS13285 ENOG4107MVR Transcriptional regulator FLM33_RS13290 ENOG4108PZW LysR family Transcriptional regulator FLM33_RS13300 ENOG4105DJB Major Facilitator Superfamily FLM33_RS13320 ENOG4105C1J atp-dependent rna helicase FLM33_RS13325 ENOG4105DVT helicase FLM33_RS13330 ENOG4108MTB glycosyl transferase family FLM33_RS13335 ENOG4105VR4 UPF0379 protein ybiJ FLM33_RS13340 ENOG4105KSC Transcriptional regulator, TraR DksA family FLM33_RS13350 ENOG4105EW6 flavin reductase domain protein, FMN-binding FLM33_RS13355 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FLM33_RS13360 ENOG4105D8X mechanosensitive ion channel FLM33_RS13365 ENOG4105CDA abc transporter atp-binding protein FLM33_RS13370 ENOG4105E5Q amino acid AbC transporter FLM33_RS13375 ENOG4107R0W ABC transporter FLM33_RS13380 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FLM33_RS13390 ENOG4108T1M outer membrane protein x FLM33_RS13395 ENOG4108I6E Sulfatase FLM33_RS13405 ENOG4105KST dependent repressor FLM33_RS13410 ENOG4105F4P )-transporter FLM33_RS13415 ENOG4105CS2 ec 3.2.1.21 FLM33_RS13420 ENOG4108TZY GntR Family Transcriptional Regulator FLM33_RS13425 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FLM33_RS13430 ENOG4105M2Z protein tyrosine serine phosphatase FLM33_RS13435 ENOG4105C5H ABC transporter FLM33_RS13445 ENOG4105DPW Major facilitator superfamily MFS_1 FLM33_RS13450 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS13455 ENOG41072TH Protein of unknown function (DUF1479) FLM33_RS13460 ENOG4108HCJ Hydrolase FLM33_RS13470 ENOG4105F1A Pyruvate formate-lyase FLM33_RS13475 ENOG4105D06 uba thif-type nad fad binding protein FLM33_RS13480 ENOG4105CVM Molybdenum cofactor synthesis domain protein FLM33_RS13485 ENOG4105D44 asparaginase FLM33_RS13490 ENOG4108JQ6 ABC transporter FLM33_RS13495 ENOG4105DEF Extracellular solute-binding protein, family 5 FLM33_RS13500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLM33_RS13505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLM33_RS13510 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FLM33_RS13515 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FLM33_RS13520 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway FLM33_RS13525 ENOG4105D8V Glucose sorbosone dehydrogenase FLM33_RS13530 ENOG4108TGY Glutathione S-transferase FLM33_RS13540 ENOG4105DZ1 carboxypeptidase FLM33_RS13545 ENOG4107FB0 transcriptional regulator DeoR family FLM33_RS13550 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FLM33_RS13555 ENOG4107QF7 multi-drug FLM33_RS13560 ENOG4108HCJ Hydrolase FLM33_RS13565 ENOG4106UW1 Major Facilitator superfamily FLM33_RS13570 ENOG4108RFG Tetr family transcriptional regulator FLM33_RS13575 ENOG4105EKQ RNA-directed DNA polymerase FLM33_RS13620 ENOG4105GWF inner membrane protein YbjM FLM33_RS13625 ENOG41090BQ Glutaredoxin FLM33_RS13630 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FLM33_RS13635 ENOG4108DBC nitroreductase FLM33_RS13645 ENOG4108RMJ sensory transduction regulator FLM33_RS13650 ENOG4107RUE extracellular solute-binding protein family 1 FLM33_RS13655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS13660 ENOG4105F38 ABC transporter, permease FLM33_RS13665 ENOG4105D38 putrescine abc transporter FLM33_RS13670 ENOG4105RBQ inner membrane protein ybjO FLM33_RS13675 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) FLM33_RS13680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLM33_RS13685 ENOG4105BZU Histidine kinase FLM33_RS13690 ENOG4106TNF Periplasmic binding protein FLM33_RS13695 ENOG4105DMR ABC, transporter FLM33_RS13700 ENOG4105GBT ABC transporter FLM33_RS13705 ENOG4106PMH Extracellular solute-binding protein family 3 FLM33_RS13710 ENOG4105E5Z arginine transporter ATP-binding subunit FLM33_RS13715 ENOG41064MM (LipO)protein FLM33_RS13725 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FLM33_RS13730 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FLM33_RS13735 ENOG4105CGD Nad-dependent epimerase dehydratase FLM33_RS13740 ENOG4105C5W Aldolase FLM33_RS13745 ENOG4105C7K acetolactate synthase FLM33_RS13755 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FLM33_RS13765 ENOG4105DWU Membrane FLM33_RS13770 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FLM33_RS13775 ENOG4105CPB ATP-dependent endonuclease of the OLD family FLM33_RS13780 ENOG4105DJY efflux transporter, rnd family, mfp subunit FLM33_RS13790 ENOG4105VEQ Cold shock protein FLM33_RS13795 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FLM33_RS13800 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FLM33_RS13805 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FLM33_RS13810 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FLM33_RS13815 ENOG4108JJ8 (ABC) transporter FLM33_RS13820 ENOG4108JJ9 ABC, transporter FLM33_RS13825 ENOG4105C3M thioredoxin reductase FLM33_RS13830 ENOG4105EW9 transcriptional regulator AsnC family FLM33_RS13835 ENOG4105CNU cell division protein FtsK FLM33_RS13840 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FLM33_RS13845 ENOG4105D1H recombination factor protein RarA FLM33_RS13850 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FLM33_RS13855 ENOG4107QY8 reductase FLM33_RS13860 ENOG4105QAX Iron-sulfur FLM33_RS13865 ENOG4107KGK dmso reductase anchor subunit FLM33_RS13870 ENOG4108ISG Major Facilitator FLM33_RS13875 ENOG4105F1A Pyruvate formate-lyase FLM33_RS13880 ENOG4105C6N Formate acetyltransferase FLM33_RS13885 ENOG4105TMB Formate nitrite transporter FLM33_RS13890 ENOG4105DDY UPF0142 protein ycaO FLM33_RS13895 ENOG4107VMU Membrane FLM33_RS13900 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FLM33_RS13905 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FLM33_RS13910 ENOG4105CAT Cytidine monophosphate kinase FLM33_RS13915 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FLM33_RS13920 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FLM33_RS13925 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FLM33_RS13930 ENOG4105BZ1 (ABC) transporter FLM33_RS13935 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FLM33_RS13940 ENOG4105T0Z Conserved Protein FLM33_RS13945 ENOG4105W49 UPF0434 protein FLM33_RS13950 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FLM33_RS13955 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FLM33_RS13960 ENOG4107S90 membrAne FLM33_RS13965 ENOG4106371 Methyltransferase FLM33_RS13970 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FLM33_RS13975 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FLM33_RS13980 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FLM33_RS13985 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FLM33_RS13990 ENOG4105EAQ (twin-arginine translocation) pathway signal FLM33_RS13995 ENOG4105C5X domain protein FLM33_RS14000 ENOG4105CGF Aromatic amino acid aminotransferase FLM33_RS14005 ENOG4105ZIT Porin Gram-negative type FLM33_RS14010 ENOG4105C5S asparaginyl-tRNA synthetase FLM33_RS14020 ENOG4107RCH Diaminopropionate ammonia-lyase FLM33_RS14025 ENOG4105C44 Serine transporter FLM33_RS14030 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FLM33_RS14035 ENOG4105CH2 amidohydrolase FLM33_RS14040 ENOG4107RH7 Nicotinate phosphoribosyltransferase FLM33_RS14045 ENOG4105CD8 aminopeptidase N FLM33_RS14055 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FLM33_RS14060 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FLM33_RS14065 ENOG4105GVF (ABC) transporter FLM33_RS14070 ENOG4108UZX fmn reductase FLM33_RS14080 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FLM33_RS14085 ENOG4105QVC MOSC domain-containing protein FLM33_RS14090 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FLM33_RS14095 ENOG4105C5H ABC transporter FLM33_RS14100 ENOG4105F1S paraquat-inducible protein a FLM33_RS14105 ENOG4105DY2 Paraquat-inducible protein b FLM33_RS14110 ENOG4108Q2G (LipO)protein FLM33_RS14115 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FLM33_RS14120 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FLM33_RS14125 ENOG4105DAN ATP-dependent protease FLM33_RS14130 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FLM33_RS14135 ENOG4105UYK outer membrane protein a FLM33_RS14140 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) FLM33_RS14145 ENOG4108RZ1 DNA transformation protein FLM33_RS14150 ENOG4105EM2 membrane FLM33_RS14155 ENOG410901E Membrane FLM33_RS14160 ENOG41088T4 Helicase IV FLM33_RS14170 ENOG4105K4P CoA-binding domain protein FLM33_RS14175 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) FLM33_RS14180 ENOG4105DR4 Methyltransferase FLM33_RS14185 ENOG4108V1U phospholipid-binding protein FLM33_RS14190 ENOG4108UQN AraC family transcriptional regulator FLM33_RS14195 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FLM33_RS14205 ENOG4108MN8 Membrane FLM33_RS14210 ENOG4107QSI ABC, transporter FLM33_RS14230 ENOG4105E3J oxidoreductase FLM33_RS14235 ENOG4105C26 Dehydrogenase FLM33_RS14240 ENOG4105DVW rieske (2Fe-2S) FLM33_RS14245 ENOG4105C94 Transporter FLM33_RS14250 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FLM33_RS14255 ENOG4105EJC lysr family transcriptional regulator FLM33_RS14260 ENOG4105CJP fad dependent oxidoreductase FLM33_RS14265 ENOG4105C26 Dehydrogenase FLM33_RS14270 ENOG4107VRI Transcriptional regulator FLM33_RS14275 ENOG4108Z86 Glutamine amidotransferase FLM33_RS14280 ENOG4105CFQ glutamine synthetase FLM33_RS14285 ENOG4105CUB amino acid FLM33_RS14300 ENOG4105CHR reductase FLM33_RS14310 ENOG4105D6F Phosphatase FLM33_RS14315 ENOG4105XH3 FLM33_RS14330 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FLM33_RS14340 ENOG4105C2W permease FLM33_RS14345 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FLM33_RS14350 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FLM33_RS14355 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FLM33_RS14360 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) FLM33_RS14370 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FLM33_RS14375 ENOG4108R86 Transcriptional regulator FLM33_RS14385 ENOG4105C26 Dehydrogenase FLM33_RS14390 ENOG4105CK7 Sodium proline symporter FLM33_RS14400 ENOG4105D9N nucleoside FLM33_RS14410 ENOG410650H (LipO)protein FLM33_RS14415 ENOG4105DBE peroxidase FLM33_RS14420 ENOG4105D5M phosphate starvation-inducible protein FLM33_RS14430 ENOG4105CHJ isochorismatase hydrolase FLM33_RS14435 ENOG4105EUB pirin domain protein FLM33_RS14440 ENOG4105HEI LysR family (Transcriptional regulator FLM33_RS14455 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FLM33_RS14465 ENOG4107XHZ cytoplasmic chaperone TorD family protein FLM33_RS14470 ENOG4108UQ5 membrane protein YcdZ FLM33_RS14485 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) FLM33_RS14495 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FLM33_RS14500 ENOG4105NAC (LipO)protein FLM33_RS14505 ENOG4108W47 Acidic protein msyB FLM33_RS14515 ENOG4105D1S lipid A biosynthesis FLM33_RS14525 ENOG4106974 biofilm formation FLM33_RS14540 ENOG4105PVA Biofilm formation regulatory protein BssS FLM33_RS14545 ENOG4105MEA DNA damage-inducible protein i FLM33_RS14550 ENOG4105EKE dihydroorotase FLM33_RS14555 ENOG4105F3T (LipO)protein FLM33_RS14560 ENOG4105EV4 Multidrug resistance protein mdtH FLM33_RS14565 ENOG4105D9U N-acetyltransferase FLM33_RS14570 ENOG4108YXG UPF0502 protein FLM33_RS14575 ENOG4105EP9 oxidoreductase FLM33_RS14580 ENOG4105CJR Integral membrane protein (MviN FLM33_RS14585 ENOG4105EQ0 Major Facilitator superfamily FLM33_RS14590 ENOG4105CR8 Transcriptional regulator FLM33_RS14595 ENOG4107QQB Ribonuclease E FLM33_RS14605 ENOG4105EI2 Pseudouridine synthase FLM33_RS14610 ENOG4108UHJ MAF-like protein FLM33_RS14615 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FLM33_RS14620 ENOG4105VGS 50s ribosomal protein l32 FLM33_RS14625 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FLM33_RS14630 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FLM33_RS14635 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FLM33_RS14640 ENOG4105CHR reductase FLM33_RS14645 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FLM33_RS14650 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FLM33_RS14655 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FLM33_RS14660 ENOG4105HHA aminodeoxychorismate lyase FLM33_RS14665 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FLM33_RS14670 ENOG4107QRG dna polymerase iii FLM33_RS14675 ENOG4105F8V Hydrolase, tatD family FLM33_RS14680 ENOG4105CI1 PTS System FLM33_RS14685 ENOG4105K59 histidine triad (HIT) protein FLM33_RS14690 ENOG41090DQ Lipoprotein FLM33_RS14695 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FLM33_RS14710 ENOG4105D0Y UPF0227 protein FLM33_RS14715 ENOG4105CEP NADH dehydrogenase FLM33_RS14720 ENOG4107MBR 17 kDa surface antigen FLM33_RS14735 ENOG4108IND Tetr family transcriptional regulator FLM33_RS14745 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FLM33_RS14750 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FLM33_RS14755 ENOG4108JA2 transcriptioN-repair coupling factor FLM33_RS14765 ENOG4105D60 lipoprotein releasing system transmembrane protein FLM33_RS14770 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FLM33_RS14775 ENOG4105D60 lipoprotein releasing system transmembrane protein FLM33_RS14780 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FLM33_RS14785 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FLM33_RS14795 ENOG4105CEY Amp-dependent synthetase and ligase FLM33_RS14805 ENOG4108HM4 ABC transporter FLM33_RS14810 ENOG4105D38 putrescine abc transporter FLM33_RS14830 ENOG4105EZE Cupin 4 family protein FLM33_RS14835 ENOG4105IFJ Histidine kinase FLM33_RS14855 ENOG4107QTF adenylosuccinate lyase FLM33_RS14860 ENOG41075W9 High frequency lysogenization protein HflD homolog FLM33_RS14865 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FLM33_RS14880 ENOG4108HMX isocitrate dehydrogenase (NADP) FLM33_RS14885 ENOG4108ZHR arsR family transcriptional regulator FLM33_RS14905 ENOG4105XDF Protein of unknown function (DUF1272) FLM33_RS14910 ENOG4105E2A Dehydrogenase FLM33_RS14920 ENOG4108Z9Z response to DNA damage stimulus FLM33_RS14925 ENOG4108N8X transition metal ion binding FLM33_RS14930 ENOG4105WEF catalase FLM33_RS14935 ENOG4105C4M (Ubiquinol oxidase) subunit I FLM33_RS14940 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FLM33_RS14970 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FLM33_RS14975 ENOG4107RSM transcriptional regulator FLM33_RS14980 ENOG4106TD9 Diguanylate cyclase FLM33_RS14985 ENOG4105DHT Metal Dependent Phosphohydrolase FLM33_RS14995 ENOG4105D1S lipid A biosynthesis FLM33_RS15000 ENOG4108NIW Leucine export protein LeuE FLM33_RS15005 ENOG4105S5I Membrane FLM33_RS15020 ENOG4106G4W FLM33_RS15025 ENOG410620I Diguanylate cyclase FLM33_RS15030 ENOG4105UCG Domain of unknown function (DUF333) FLM33_RS15035 ENOG4105K78 MarR family Transcriptional regulator FLM33_RS15040 ENOG4105EWC Purine nucleoside phosphorylase FLM33_RS15045 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FLM33_RS15050 ENOG4105DJ2 Major Facilitator Superfamily FLM33_RS15055 ENOG4105R1U AraC Family Transcriptional Regulator FLM33_RS15060 ENOG4108VMM UPF0756 membrane protein FLM33_RS15065 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FLM33_RS15070 ENOG4108XNZ glycosyl transferase FLM33_RS15075 ENOG4105Y50 Virulence Protein FLM33_RS15080 ENOG4105EKQ RNA-directed DNA polymerase FLM33_RS15085 ENOG4105KT5 UmuD protein FLM33_RS15090 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FLM33_RS15095 ENOG4105CBN LysR family transcriptional regulator FLM33_RS15100 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FLM33_RS15105 ENOG4105F27 Major Facilitator FLM33_RS15125 ENOG4108V06 Glutathione peroxidase FLM33_RS15135 ENOG4106AKX UPF0229 protein FLM33_RS15140 ENOG4105CYN Serine protein kinase FLM33_RS15145 ENOG4105GNX MltA-interacting MipA family protein FLM33_RS15150 ENOG4105CV8 reductase FLM33_RS15155 ENOG4105DSB aldose 1-epimerase FLM33_RS15160 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FLM33_RS15165 ENOG4105E0X reductase FLM33_RS15170 ENOG4105VUT cytoplasmic protein FLM33_RS15175 ENOG4105N1F Hnh endonuclease FLM33_RS15185 ENOG4108RWI nicotinamidase FLM33_RS15190 ENOG4105HDK L-asparaginase FLM33_RS15195 ENOG4105D07 Signal peptide peptidase, SppA FLM33_RS15200 ENOG41069NU Nitroreductase FLM33_RS15210 ENOG4105SBG acid phosphatase FLM33_RS15215 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FLM33_RS15220 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FLM33_RS15230 ENOG4105D82 Glutamate dehydrogenase FLM33_RS15235 ENOG4105M6F mutator MutT protein FLM33_RS15240 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FLM33_RS15245 ENOG4107RM6 sulfurtransferase FLM33_RS15250 ENOG4108VGW abc transporter atp-binding protein FLM33_RS15260 ENOG4105VNH ABC transporter solute-binding protein FLM33_RS15265 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FLM33_RS15270 ENOG4108N5C SNARE associated Golgi protein-related protein FLM33_RS15275 ENOG4108RSN SNARE associated Golgi FLM33_RS15280 ENOG4105CGK Exodeoxyribonuclease III FLM33_RS15290 ENOG4105F4X arginine FLM33_RS15295 ENOG4105C26 Dehydrogenase FLM33_RS15300 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FLM33_RS15310 ENOG4108SPG Periplasmic Protein FLM33_RS15315 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FLM33_RS15325 ENOG4105KKI DNA-binding transcriptional activator OsmE FLM33_RS15330 ENOG4105VZJ PTS System FLM33_RS15340 ENOG4105CK1 PTS System FLM33_RS15345 ENOG4105VCP PTS System FLM33_RS15350 ENOG4105EZV Transcriptional regulator FLM33_RS15355 ENOG4105F8D glycoside hydrolase family 4 FLM33_RS15360 ENOG410901P UPF0249 protein FLM33_RS15365 ENOG4105CH6 catalase FLM33_RS15370 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) FLM33_RS15375 ENOG4108ETY sodium dicarboxylate symporter FLM33_RS15380 ENOG4107K5X Membrane-bound metal-dependent hydrolase FLM33_RS15385 ENOG4105CHR reductase FLM33_RS15390 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FLM33_RS15395 ENOG4107PN8 YfeABCD locus regulator FLM33_RS15400 ENOG4105NAU thioesterase Superfamily protein FLM33_RS15405 ENOG4107RNH Outer membrane receptor FepA FLM33_RS15410 ENOG4107835 probably involved in intracellular septation (By similarity) FLM33_RS15415 ENOG4108S3I UPF0259 membrane protein FLM33_RS15420 ENOG4105PI0 Ferredoxin FLM33_RS15425 ENOG4105EIF outer membrane protein W FLM33_RS15430 ENOG4107E2E PKHD-type hydroxylase FLM33_RS15435 ENOG4108IU3 tonb-dependent siderophore receptor FLM33_RS15460 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FLM33_RS15465 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FLM33_RS15470 ENOG4105DK0 Indole-3-glycerol phosphate synthase FLM33_RS15475 ENOG4108EFP Anthranilate synthase component II FLM33_RS15480 ENOG4105CRQ synthase (Component I) FLM33_RS15485 ENOG4105DB7 PHP domain protein FLM33_RS15490 ENOG4107RTD sua5 ycio yrdc ywlc family protein FLM33_RS15500 ENOG4105ETT transcriptional Regulator, LysR family FLM33_RS15510 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FLM33_RS15515 ENOG4105UBK short-chain dehydrogenase reductase FLM33_RS15525 ENOG4105ERU peptidase FLM33_RS15530 ENOG4105RKX Protein of unknown function (DUF2498) FLM33_RS15535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FLM33_RS15540 ENOG4107R11 Transcriptional regulator FLM33_RS15550 ENOG4107QM5 aconitate hydratase FLM33_RS15555 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FLM33_RS15560 ENOG4105EYK Phosphatidylglycerophosphatase B FLM33_RS15565 ENOG4105Q4A inner membrane protein yciS FLM33_RS15570 ENOG4105CFV Tetratricopeptide repeat protein FLM33_RS15580 ENOG4108ZJT translation initiation factor, Sui1 FLM33_RS15585 ENOG41061RM osmotically inducible lipoprotein FLM33_RS15590 ENOG4105N2W Transcriptional regulator FLM33_RS15600 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FLM33_RS15605 ENOG4105Q4T oxidoreductase FLM33_RS15610 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FLM33_RS15620 ENOG4105ETS cytosine purines uracil thiamine allantoin FLM33_RS15625 ENOG4108JQ2 peptide transport system atp-binding protein FLM33_RS15630 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FLM33_RS15635 ENOG4108EU3 peptide transport system, permease FLM33_RS15640 ENOG4108EKA peptide transport system, permease FLM33_RS15645 ENOG4108J59 Extracellular solute-binding protein, family 5 FLM33_RS15660 ENOG41063ZK Transcriptional Regulator AraC Family FLM33_RS15665 ENOG4105CH2 amidohydrolase FLM33_RS15675 ENOG4105E51 psp operon transcriptional activator FLM33_RS15680 ENOG41087YS Phage shock protein A FLM33_RS15685 ENOG4105YYT phage shock protein B FLM33_RS15690 ENOG4105FM1 phage shock protein C FLM33_RS15695 ENOG4105NNG Peripheral inner membrane phage-shock protein FLM33_RS15700 ENOG4105CM6 amino acid regulated cytosolic protein FLM33_RS15705 ENOG4106K28 UPF0283 membrane protein FLM33_RS15710 ENOG4105W8I Transcriptional regulator FLM33_RS15720 ENOG4108JU8 Transcriptional regulator FLM33_RS15725 ENOG4108KK1 membrane protein AbrB duplication FLM33_RS15730 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FLM33_RS15735 ENOG4107S8C mandelate racemase muconate lactonizing FLM33_RS15740 ENOG4105KXI murein peptide amidase A FLM33_RS15750 ENOG4107QSI ABC, transporter FLM33_RS15765 ENOG4105EQ2 LysR family Transcriptional regulator FLM33_RS15770 ENOG4105ENX hydrolase FLM33_RS15775 ENOG4107RTG Major Facilitator superfamily FLM33_RS15795 ENOG4105CBN LysR family transcriptional regulator FLM33_RS15810 ENOG4108Z0Z intracellular protease Pfpi family FLM33_RS15890 ENOG4108ZG0 Ompa motb domain protein FLM33_RS15900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FLM33_RS15985 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FLM33_RS15990 ENOG4108XFH Transcriptional regulator FLM33_RS16015 ENOG4105HEI LysR family (Transcriptional regulator FLM33_RS16055 ENOG4105D01 (LipO)protein FLM33_RS16065 ENOG4108UMI ABC transporter, permease FLM33_RS16070 ENOG4105CGF Aromatic amino acid aminotransferase FLM33_RS16080 ENOG4105F7P transcriptional regulator AsnC family FLM33_RS16085 ENOG4105C85 amino acid FLM33_RS16100 ENOG4105D9R oxidoreductase FLM33_RS16105 ENOG4105E98 transcriptional regulator DeoR family FLM33_RS16110 ENOG4107RX3 Mg2 transporter protein cora family protein FLM33_RS16115 ENOG4105C1J atp-dependent rna helicase FLM33_RS16125 ENOG4108RW8 Universal stress protein F FLM33_RS16135 ENOG4105FCK Membrane FLM33_RS16140 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FLM33_RS16145 ENOG4105IKK cytoplasmic protein FLM33_RS16150 ENOG41090X5 Heat shock protein hslJ FLM33_RS16155 ENOG4105C5I Dehydrogenase FLM33_RS16160 ENOG4108KF1 Membrane FLM33_RS16165 ENOG4107H52 Dicarboxylate transport FLM33_RS16170 ENOG410689M (LipO)protein FLM33_RS16175 ENOG4105WXT Conserved Protein FLM33_RS16180 ENOG4108WFR AraC Family Transcriptional Regulator FLM33_RS16185 ENOG4105C26 Dehydrogenase FLM33_RS16200 ENOG4105F11 amine oxidase FLM33_RS16205 ENOG4105DXM phenylacetic acid degradation protein FLM33_RS16210 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FLM33_RS16215 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FLM33_RS16220 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FLM33_RS16225 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FLM33_RS16230 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FLM33_RS16235 ENOG4105E39 Enoyl-CoA hydratase FLM33_RS16240 ENOG4108UKI Enoyl-CoA hydratase FLM33_RS16245 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FLM33_RS16250 ENOG4108ZJI phenylacetic acid degradation protein FLM33_RS16255 ENOG4105CHU acetyl-coa acetyltransferase FLM33_RS16260 ENOG4105DZS Phenylacetate-CoA ligase FLM33_RS16265 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FLM33_RS16270 ENOG4108Z0R Transferase FLM33_RS16280 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FLM33_RS16285 ENOG4105CQ7 ATP-dependent helicase FLM33_RS16295 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FLM33_RS16315 ENOG410642W LysR family Transcriptional regulator FLM33_RS16320 ENOG4108FN7 Aldo keto reductase FLM33_RS16325 ENOG4105D82 Glutamate dehydrogenase FLM33_RS16335 ENOG4105C8Y Acetylornithine aminotransferase FLM33_RS16340 ENOG4105F4X arginine FLM33_RS16345 ENOG4105C26 Dehydrogenase FLM33_RS16350 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FLM33_RS16355 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FLM33_RS16365 ENOG4105CSH Transporter FLM33_RS16370 ENOG4107DB1 DUF218 domain FLM33_RS16380 ENOG4105C26 Dehydrogenase FLM33_RS16385 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FLM33_RS16390 ENOG4105VPI YqaE family transport protein FLM33_RS16395 ENOG41064WM Uncharacterized protein YcgX FLM33_RS16405 ENOG41066VF YeeE YedE family protein FLM33_RS16420 ENOG41061EV selenium-binding protein YdfZ FLM33_RS16430 ENOG4105C87 Aminotransferase class I and II FLM33_RS16435 ENOG4105CI1 PTS System FLM33_RS16440 ENOG4107P2S Transcriptional regulator FLM33_RS16445 ENOG4106J39 exported protein FLM33_RS16450 ENOG4105EIP mannose-6-phosphate isomerase FLM33_RS16455 ENOG4107GFK fumarate FLM33_RS16460 ENOG4105C9Q fumarate hydratase class II FLM33_RS16470 ENOG4105JJR Histidine kinase FLM33_RS16480 ENOG4107EXC regulatoR FLM33_RS16485 ENOG4105RA2 Membrane FLM33_RS16490 ENOG410642E Short chain dehydrogenase FLM33_RS16495 ENOG4105D5Q Arginine ornithine antiporter FLM33_RS16500 ENOG4105C5D exported protein FLM33_RS16510 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FLM33_RS16515 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FLM33_RS16520 ENOG410671Z uncharacterized protein ydiH FLM33_RS16525 ENOG4105Q9Y Universal stress protein FLM33_RS16530 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FLM33_RS16535 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FLM33_RS16545 ENOG4105CFC Transporter FLM33_RS16550 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FLM33_RS16560 ENOG4106KR7 LysR family Transcriptional regulator FLM33_RS16565 ENOG4108DG9 Smr protein MutS2 FLM33_RS16570 ENOG4107HP6 Transcriptional regulator FLM33_RS16580 ENOG4107QNJ CoA-transferase subunit B FLM33_RS16585 ENOG4105CHU acetyl-coa acetyltransferase FLM33_RS16590 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FLM33_RS16595 ENOG4105F2Z 3-oxoadipate enol-lactonase FLM33_RS16600 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FLM33_RS16610 ENOG4107GFK fumarate FLM33_RS16630 ENOG4108MRH transcriptional regulatory protein FLM33_RS16635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FLM33_RS16645 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FLM33_RS16650 ENOG4105DWT malate dehydrogenase (quinone) FLM33_RS16655 ENOG4108K70 Transcriptional regulator FLM33_RS16660 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FLM33_RS16665 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase FLM33_RS16670 ENOG4107TT2 Auxin Efflux Carrier FLM33_RS16700 ENOG4105DSF transport protein FLM33_RS16705 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FLM33_RS16710 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) FLM33_RS16720 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FLM33_RS16730 ENOG4105CTD carboxy-peptidase FLM33_RS16735 ENOG4105D94 Major Facilitator Superfamily FLM33_RS16740 ENOG4106NZI LysR family Transcriptional regulator FLM33_RS16745 ENOG4105DAG ROK family FLM33_RS16750 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FLM33_RS16755 ENOG4105CMQ Chloride channel FLM33_RS16765 ENOG4107KGK dmso reductase anchor subunit FLM33_RS16770 ENOG4105QAX Iron-sulfur FLM33_RS16775 ENOG4107QY8 reductase FLM33_RS16780 ENOG4105KBG Protein of unknown function (DUF1161) FLM33_RS16790 ENOG4108MK9 spermidine N(1)-acetyltransferase FLM33_RS16795 ENOG4105M5Q UPF0482 protein FLM33_RS16800 ENOG4105KK4 UPF0060 membrane protein FLM33_RS16805 ENOG4108I5G Major Facilitator superfamily FLM33_RS16810 ENOG4105DEI Mannitol dehydrogenase FLM33_RS16815 ENOG4108U51 Universal stress protein FLM33_RS16820 ENOG4107XBN GntR Family Transcriptional Regulator FLM33_RS16825 ENOG4105EMU Dehydrogenase FLM33_RS16830 ENOG4105DGW oligopeptidase A FLM33_RS16840 ENOG4105R1U AraC Family Transcriptional Regulator FLM33_RS16845 ENOG4108RAV Conserved protein FLM33_RS16860 ENOG4105C6Z Gluconate FLM33_RS16865 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FLM33_RS16870 ENOG4105FB2 class II Aldolase FLM33_RS16875 ENOG4105G63 Type III effector Hrp-dependent FLM33_RS16885 ENOG4105MVE transcriptional regulator FLM33_RS16900 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FLM33_RS16905 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FLM33_RS16910 ENOG4105CNT hydrolase family 2 FLM33_RS16915 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS16930 ENOG4105ECQ AraC Family Transcriptional Regulator FLM33_RS16950 ENOG4105C32 Amino acid ABC transporter (Permease) FLM33_RS16955 ENOG4105CNN ABC, transporter FLM33_RS16960 ENOG4105C0Z ABC transporter FLM33_RS16965 ENOG4108IV0 ABC, transporter FLM33_RS16975 ENOG4105E5W Transporter FLM33_RS16980 ENOG4108594 Permease of the drug metabolite transporter FLM33_RS16985 ENOG4106DNR multiple antibiotic resistance protein FLM33_RS16990 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FLM33_RS16995 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FLM33_RS17005 ENOG41082NP Multiple antibiotic resistance FLM33_RS17010 ENOG4105F27 Major Facilitator FLM33_RS17015 ENOG4105JAB phenazine biosynthesis protein, phzf family FLM33_RS17025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FLM33_RS17030 ENOG4105C0A alcohol dehydrogenase FLM33_RS17035 ENOG4107S2N Type III effector Hrp-dependent FLM33_RS17040 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FLM33_RS17045 ENOG4105MVE transcriptional regulator FLM33_RS17050 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FLM33_RS17060 ENOG4105EGI Transcriptional regulator FLM33_RS17065 ENOG4105C26 Dehydrogenase FLM33_RS17070 ENOG4105CSV Glutaminase FLM33_RS17075 ENOG4105M0C cytoplasmic protein FLM33_RS17080 ENOG4105BZU Histidine kinase FLM33_RS17090 ENOG4107QZW Altronate oxidoreductase FLM33_RS17140 ENOG4105F9N Major Facilitator Superfamily FLM33_RS17155 ENOG4105EGI Transcriptional regulator FLM33_RS17160 ENOG4105EA8 2-Nitropropane dioxygenase FLM33_RS17165 ENOG4108UMI ABC transporter, permease FLM33_RS17175 ENOG4105D01 (LipO)protein FLM33_RS17185 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FLM33_RS17200 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions FLM33_RS17220 ENOG4108KSA LysR family transcriptional regulator FLM33_RS17225 ENOG41061H0 Monooxygenase FLM33_RS17230 ENOG4105C2W permease FLM33_RS17235 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) FLM33_RS17240 ENOG4105VT2 5-hydroxyisourate hydrolase FLM33_RS17245 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FLM33_RS17250 ENOG4105CAF HipA N-terminal domain protein FLM33_RS17255 ENOG4105F32 YngK protein FLM33_RS17265 ENOG4105CW0 outer membrane usher protein FLM33_RS17270 ENOG4108VCD Chaperone FLM33_RS17285 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FLM33_RS17300 ENOG4105BZU Histidine kinase FLM33_RS17305 ENOG4105NIV Esterase FLM33_RS17320 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FLM33_RS17325 ENOG4105C54 Major Facilitator superfamily FLM33_RS17330 ENOG4105F8D glycoside hydrolase family 4 FLM33_RS17335 ENOG4105CI1 PTS System FLM33_RS17340 ENOG4107YCY Transcriptional regulator FLM33_RS17350 ENOG4105JQN Transcriptional regulator FLM33_RS17360 ENOG4107VHA regulatoR FLM33_RS17365 ENOG4105BZW Glycerate kinase FLM33_RS17385 ENOG4105CHU acetyl-coa acetyltransferase FLM33_RS17390 ENOG4105CHR reductase FLM33_RS17395 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FLM33_RS17410 ENOG4105EDR glucose galactose transporter FLM33_RS17415 ENOG4108RVA ribokinase FLM33_RS17420 ENOG4105UP7 3-epimerase FLM33_RS17425 ENOG4105E98 transcriptional regulator DeoR family FLM33_RS17430 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FLM33_RS17435 ENOG4105CMG Carbohydrate kinase FLM33_RS17440 ENOG4105MVE transcriptional regulator FLM33_RS17455 ENOG4105CPC Aldo Keto reductase FLM33_RS17460 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis FLM33_RS17465 ENOG4107SET aldo keto reductase FLM33_RS17470 ENOG4105CPC Aldo Keto reductase FLM33_RS17475 ENOG4105EQ2 LysR family Transcriptional regulator FLM33_RS17480 ENOG4105RHY Pfam:UPF0157 FLM33_RS17485 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta FLM33_RS17495 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FLM33_RS17500 ENOG4105CXY transporter FLM33_RS17505 ENOG4109066 lysm domain bon superfamily protein FLM33_RS17535 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS17540 ENOG4105C2J ABC transporter FLM33_RS17545 ENOG4105CNN ABC, transporter FLM33_RS17560 ENOG4107PP3 Acetylornithine deacetylase FLM33_RS17575 ENOG4105HEI LysR family (Transcriptional regulator FLM33_RS17580 ENOG4105CBN LysR family transcriptional regulator FLM33_RS17590 ENOG410829K Lysine exporter protein (Lyse ygga) FLM33_RS17595 ENOG4105DM4 PTS System FLM33_RS17600 ENOG4108YRF PTS System FLM33_RS17615 ENOG4105UP7 3-epimerase FLM33_RS17620 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FLM33_RS17630 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FLM33_RS17635 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS17645 ENOG4105FCD Major Facilitator FLM33_RS17675 ENOG4105CSH Transporter FLM33_RS17680 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FLM33_RS17685 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLM33_RS17695 ENOG4105CBN LysR family transcriptional regulator FLM33_RS17710 ENOG4105C5R Aminotransferase FLM33_RS17720 ENOG4105E5Q amino acid AbC transporter FLM33_RS17740 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FLM33_RS17765 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FLM33_RS17785 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FLM33_RS17800 ENOG4105R1U AraC Family Transcriptional Regulator FLM33_RS17805 ENOG41089BK Glutamine amido-transferase FLM33_RS17850 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FLM33_RS17855 ENOG4107QUY Guanine deaminase FLM33_RS17860 ENOG4105BZU Histidine kinase FLM33_RS17865 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS17875 ENOG4105CIB oxidoreductase Domain protein FLM33_RS17890 ENOG4105ETU transcriptional activator (TenA FLM33_RS17895 ENOG4108YI8 ABC transporter FLM33_RS17900 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FLM33_RS17905 ENOG4107Z6I Thiamine biosynthesis protein FLM33_RS17910 ENOG4108JPW Aminotransferase FLM33_RS17915 ENOG4105DY8 decarboxylase FLM33_RS17930 ENOG4105E0F Histidine kinase FLM33_RS17940 ENOG4108J2P Alpha beta hydrolase fold FLM33_RS17945 ENOG4108IGT Dipeptidase FLM33_RS17955 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FLM33_RS17970 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FLM33_RS17975 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF FLM33_RS17980 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FLM33_RS18000 ENOG4106KR7 LysR family Transcriptional regulator FLM33_RS18005 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FLM33_RS18010 ENOG4105D6Z AFG1 family ATPase FLM33_RS18015 ENOG4105KT7 mgtC SapB transporter FLM33_RS18020 ENOG4108KUU Inner membrane metabolite transport protein ydjE FLM33_RS18025 ENOG4105C5Q Transcriptional regulator FLM33_RS18030 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FLM33_RS18035 ENOG4105FFC UPF0187 protein FLM33_RS18060 ENOG4108Z9K Osmotically inducible protein FLM33_RS18070 ENOG4108YDI single-species biofilm formation on inanimate substrate FLM33_RS18095 ENOG4105CG3 alpha amylase, catalytic region FLM33_RS18105 ENOG4108N8X transition metal ion binding FLM33_RS18120 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FLM33_RS18125 ENOG4105N0E Protein of unknown function (DUF2543) FLM33_RS18130 ENOG4105EQ2 LysR family Transcriptional regulator FLM33_RS18150 ENOG4107R1I NAD-dependent malic enzyme FLM33_RS18160 ENOG4105C5H ABC transporter FLM33_RS18175 ENOG4105DQ4 alcohol dehydrogenase FLM33_RS18190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLM33_RS18195 ENOG4108JQ6 ABC transporter FLM33_RS18210 ENOG4105F27 Major Facilitator FLM33_RS18220 ENOG4105CSR polyphosphate kinase 2 FLM33_RS18235 ENOG4108MG3 formate dehydrogenase FLM33_RS18240 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FLM33_RS18265 ENOG4108UKV benzoate 1,2-dioxygenase FLM33_RS18275 ENOG410626B catechol 1,2-dioxygenase FLM33_RS18280 ENOG4105NN7 muconolactone delta-isomerase FLM33_RS18285 ENOG4105DTQ mandelate racemase muconate lactonizing FLM33_RS18290 ENOG4107HP6 Transcriptional regulator FLM33_RS18305 ENOG4107QND Nitrite extrusion protein FLM33_RS18310 ENOG4105CRU nitrate reductase, alpha subunit FLM33_RS18315 ENOG4108IUE nitrate reductase beta subunit FLM33_RS18320 ENOG4108NZN Respiratory nitrate reductase 2 delta chain FLM33_RS18325 ENOG4105D0D Nitrate reductase 2, gamma subunit FLM33_RS18330 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FLM33_RS18335 ENOG4107RCV ABC transporter, permease FLM33_RS18340 ENOG4105C4Y ABC transporter FLM33_RS18345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS18350 ENOG4108MEJ flavin reductase domain protein FLM33_RS18365 ENOG4105CT4 transporter FLM33_RS18380 ENOG4108N27 Glutathione S-transferase FLM33_RS18390 ENOG4105CDA abc transporter atp-binding protein FLM33_RS18395 ENOG4105DRP amino acid AbC transporter FLM33_RS18405 ENOG4105EAB amino acid AbC transporter FLM33_RS18420 ENOG4105DEN Luciferase family FLM33_RS18430 ENOG4105EQ2 LysR family Transcriptional regulator FLM33_RS18435 ENOG4105C85 amino acid FLM33_RS18445 ENOG4108NS2 receptor FLM33_RS18450 ENOG4105CHB tonB-dependent Receptor FLM33_RS18455 ENOG4105CI2 imidazolone-5-propionate hydrolase FLM33_RS18460 ENOG41065TG regulatoR FLM33_RS18470 ENOG4105DU0 nucleoside hydrolase FLM33_RS18475 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FLM33_RS18485 ENOG4108Z7F N-acetyltransferase FLM33_RS18490 ENOG4108T9Y Inner membrane protein ydcZ FLM33_RS18495 ENOG4105R71 cytoplasmic protein FLM33_RS18500 ENOG4105DEF Extracellular solute-binding protein, family 5 FLM33_RS18510 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FLM33_RS18515 ENOG410654E Membrane FLM33_RS18540 ENOG4105C26 Dehydrogenase FLM33_RS18545 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FLM33_RS18550 ENOG4105D81 ABC transporter, permease FLM33_RS18555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FLM33_RS18560 ENOG4107TYH extracellular solute-binding protein family 1 FLM33_RS18565 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLM33_RS18570 ENOG4105C4M (Ubiquinol oxidase) subunit I FLM33_RS18575 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FLM33_RS18595 ENOG4105CFP Peptidase U32 FLM33_RS18605 ENOG4108JCI Transcriptional regulator FLM33_RS18610 ENOG4105DKK Benzoate FLM33_RS18615 ENOG4105UEI Transcriptional Regulator AraC Family FLM33_RS18625 ENOG4108KKZ (LipO)protein FLM33_RS18630 ENOG41088CC tellurite resistance protein tehB FLM33_RS18635 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein FLM33_RS18640 ENOG4107WE3 acetyltransferase YdcK FLM33_RS18645 ENOG4108Z9I -acetyltransferase FLM33_RS18660 ENOG4105EBR Carboxylesterase FLM33_RS18665 ENOG4105E32 cytoplasmic protein FLM33_RS18670 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FLM33_RS18675 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FLM33_RS18680 ENOG4105DDW LysR family Transcriptional regulator FLM33_RS18700 ENOG4105CPW cytochrome b561 FLM33_RS18720 ENOG4105EQ0 Major Facilitator superfamily FLM33_RS18725 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FLM33_RS18730 ENOG4105D9R oxidoreductase FLM33_RS18740 ENOG4105CS2 ec 3.2.1.21 FLM33_RS18750 ENOG4105M9B inner membrane protein ydgK FLM33_RS18775 ENOG4108UQQ Electron transport complex FLM33_RS18785 ENOG4105CSM endonuclease III FLM33_RS18795 ENOG4108K3A Glutathione S-transferase FLM33_RS18800 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FLM33_RS18805 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FLM33_RS18810 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FLM33_RS18815 ENOG410642K Lysozyme inhibitor FLM33_RS18820 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FLM33_RS18825 ENOG4108XTF Outer Membrane Lipoprotein FLM33_RS18830 ENOG4105BZU Histidine kinase FLM33_RS18845 ENOG4105Y49 secretion protein, HlyD family FLM33_RS18850 ENOG4105DSW Fusaric acid resistance protein FLM33_RS18855 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FLM33_RS18860 ENOG4107RGM aldo keto reductase FLM33_RS18865 ENOG4105XZD Fe-S protein FLM33_RS18870 ENOG4108WUH Transcriptional regulator, TetR family FLM33_RS18875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLM33_RS18880 ENOG4108UYE Lactoylglutathione lyase FLM33_RS18885 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FLM33_RS18890 ENOG4105M2J Glutaredoxin FLM33_RS18895 ENOG4105K4H Nlp p60 protein FLM33_RS18905 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FLM33_RS18910 ENOG4105F27 Major Facilitator FLM33_RS18920 ENOG4105ETE Transcriptional regulator (LacI family FLM33_RS18925 ENOG4105F52 Transcriptional regulator FLM33_RS18930 ENOG4105CZQ inner membrane transport protein YdhC FLM33_RS18935 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FLM33_RS18940 ENOG4108R6K riboflavin synthase, subunit alpha FLM33_RS18945 ENOG4107QI1 Mate efflux family protein FLM33_RS18955 ENOG4108URH decarboxylase FLM33_RS18990 ENOG4105CY0 Metallo-Beta-Lactamase FLM33_RS19015 ENOG4107B2H carbonic anhydrase FLM33_RS19025 ENOG4105E98 transcriptional regulator DeoR family FLM33_RS19030 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FLM33_RS19055 ENOG4105C3U ABC transporter FLM33_RS19060 ENOG4108JQ7 (ABC) transporter FLM33_RS19105 ENOG4105EMY transcriptional regulator FLM33_RS19115 ENOG4107TTD cytosine deaminase FLM33_RS19120 ENOG4105KME endoribonuclease L-psp FLM33_RS19140 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FLM33_RS19145 ENOG4105CQB FAD linked oxidase domain protein FLM33_RS19170 ENOG4106NZI LysR family Transcriptional regulator FLM33_RS19180 ENOG4107QNJ CoA-transferase subunit B FLM33_RS19185 ENOG4105CHU acetyl-coa acetyltransferase FLM33_RS19190 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FLM33_RS19195 ENOG4105CY2 Citrate transporter FLM33_RS19200 ENOG4105DTD Dehydrogenase FLM33_RS19215 ENOG4105C7K acetolactate synthase FLM33_RS19220 ENOG4105CHR reductase FLM33_RS19230 ENOG4105BZS acriflavin resistance protein FLM33_RS19250 ENOG4105E3W Two component transcriptional regulator (Winged helix family FLM33_RS19255 ENOG41062D9 Histidine kinase FLM33_RS19270 ENOG410822N TonB family FLM33_RS19285 ENOG4108M1T Cytochrome c-type biogenesis protein FLM33_RS19290 ENOG4105KWW Biogenesis protein FLM33_RS19295 ENOG4107QX9 Thiol disulfide interChange protein FLM33_RS19300 ENOG4105DA4 cytochrome c-type biogenesis protein FLM33_RS19305 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FLM33_RS19315 ENOG41060IM Heme exporter protein FLM33_RS19320 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FLM33_RS19325 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FLM33_RS19355 ENOG4107Z33 ABC transporter, permease FLM33_RS19360 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FLM33_RS19365 ENOG4105DG4 malate L-lactate dehydrogenase FLM33_RS19370 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FLM33_RS19395 ENOG41083G8 Multidrug resistance protein MdtM FLM33_RS19405 ENOG4105KZM cytoplasmic protein FLM33_RS19410 ENOG4105CDA abc transporter atp-binding protein FLM33_RS19415 ENOG4105E5Q amino acid AbC transporter FLM33_RS19420 ENOG4106PMH Extracellular solute-binding protein family 3 FLM33_RS19440 ENOG4105DQ5 transport system permease protein FLM33_RS19445 ENOG4105E0A ABC, transporter FLM33_RS19455 ENOG4108IY8 ABC, transporter FLM33_RS19460 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FLM33_RS19480 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FLM33_RS19485 ENOG4106KR7 LysR family Transcriptional regulator FLM33_RS19490 ENOG4108T2C cysteine dioxygenase type I FLM33_RS19505 ENOG4108SC4 )-transporter FLM33_RS19510 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) FLM33_RS19515 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) FLM33_RS19520 ENOG4105IKQ hydratase FLM33_RS19525 ENOG4107UB2 Alpha beta hydrolase fold FLM33_RS19530 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FLM33_RS19535 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FLM33_RS19540 ENOG4108K2P TRANSCRIPTIONal FLM33_RS19545 ENOG4105S10 periplasmic binding protein FLM33_RS19550 ENOG4105EHG Permease protein FLM33_RS19555 ENOG4108W0P ABC transporter FLM33_RS19560 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein FLM33_RS19565 ENOG4105E2X shikimate dehydrogenase FLM33_RS19570 ENOG4105DJB Major Facilitator Superfamily FLM33_RS19585 ENOG4105RFR Protein of unknown function (DUF2767) FLM33_RS19600 ENOG4105CA9 Pyruvate kinase FLM33_RS19610 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FLM33_RS19615 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FLM33_RS19620 ENOG4105C9B Cysteine desulfurase FLM33_RS19625 ENOG4105JRK feS assembly protein SufD FLM33_RS19630 ENOG4105C3K feS assembly ATPase SufC FLM33_RS19635 ENOG4105DIW FeS assembly protein SUFB FLM33_RS19640 ENOG4108Z4V iron-sulfur cluster assembly FLM33_RS19660 ENOG4105KBX Transcriptional regulator, TetR family FLM33_RS19665 ENOG4105DMF Dehydrogenase FLM33_RS19690 ENOG4106KR7 LysR family Transcriptional regulator FLM33_RS19700 ENOG4105EHG Permease protein FLM33_RS19705 ENOG4105E0A ABC, transporter FLM33_RS19715 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FLM33_RS19730 ENOG4105KA0 thioesterase Superfamily protein FLM33_RS19735 ENOG4105CQB FAD linked oxidase domain protein FLM33_RS19740 ENOG4105IPI Membrane FLM33_RS19750 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FLM33_RS19765 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FLM33_RS19775 ENOG4105CNG UPF0061 protein FLM33_RS19780 ENOG4108QBX (LipO)protein FLM33_RS19790 ENOG4108V06 Glutathione peroxidase FLM33_RS19795 ENOG4105D01 (LipO)protein FLM33_RS19800 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) FLM33_RS19810 ENOG4105RQF LysR family Transcriptional regulator FLM33_RS19815 ENOG4105MWK D-amino acid dehydrogenase, small subunit FLM33_RS19825 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FLM33_RS19830 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FLM33_RS19835 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FLM33_RS19850 ENOG41082NX 50s ribosomal protein l35 FLM33_RS19855 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FLM33_RS19870 ENOG4108NE3 Salt-induced outer membrane protein FLM33_RS19875 ENOG4105DE4 1-phosphofructokinase FLM33_RS19880 ENOG4105P10 Uncharacterized protein ydiZ FLM33_RS19890 ENOG410822N TonB family FLM33_RS19895 ENOG4105K9H YciI-like protein FLM33_RS19905 ENOG4108YYC ycei family FLM33_RS19915 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FLM33_RS19920 ENOG4108W5H UPF0263 protein FLM33_RS19925 ENOG4105EYW Ion transport protein FLM33_RS19930 ENOG4108JQ7 (ABC) transporter FLM33_RS19935 ENOG4105C3U ABC transporter FLM33_RS19940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLM33_RS19945 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLM33_RS19950 ENOG4108J59 Extracellular solute-binding protein, family 5 FLM33_RS19955 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FLM33_RS19965 ENOG4105C0A alcohol dehydrogenase FLM33_RS19970 ENOG4107104 thymidine kinase FLM33_RS19985 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FLM33_RS19990 ENOG4105I93 response regulator FLM33_RS19995 ENOG4105D78 K07001 NTE family protein FLM33_RS20005 ENOG4105CIY formyltetrahydrofolate deformylase FLM33_RS20050 ENOG41076YT nitrate reductase, gamma subunit FLM33_RS20055 ENOG4105R3A Nitrate reductase FLM33_RS20060 ENOG4108IUE nitrate reductase beta subunit FLM33_RS20065 ENOG4105CRU nitrate reductase, alpha subunit FLM33_RS20075 ENOG4105DQQ Major facilitator superfamily MFS_1 FLM33_RS20080 ENOG4105BZU Histidine kinase FLM33_RS20085 ENOG4105WH1 Two component transcriptional regulator luxr family FLM33_RS20090 ENOG4105ID0 Putative invasin FLM33_RS20100 ENOG4107QZF nitrite reductase NADPH large subunit FLM33_RS20105 ENOG4105D7T ABC transporter FLM33_RS20115 ENOG4105I5W Transporter FLM33_RS20125 ENOG41090EX DsrE family FLM33_RS20135 ENOG4108NH8 Cation transport protein FLM33_RS20140 ENOG4105WS7 Cation transport regulator FLM33_RS20145 ENOG4105EWV Sodium calcium exchanger membrane region FLM33_RS20150 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FLM33_RS20155 ENOG41063JG Transcriptional regulator FLM33_RS20160 ENOG4108YY7 Invasion gene expression up-regulator SirB FLM33_RS20165 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FLM33_RS20170 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FLM33_RS20175 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FLM33_RS20185 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FLM33_RS20190 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FLM33_RS20195 ENOG4105CHH sulfate transporter FLM33_RS20205 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FLM33_RS20210 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FLM33_RS20215 ENOG4105C3G gtp-binding protein FLM33_RS20280 ENOG4108ZG0 Ompa motb domain protein FLM33_RS20300 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FLM33_RS20305 ENOG4105D3G Pseudouridine synthase FLM33_RS20315 ENOG4105F04 LysR family Transcriptional regulator FLM33_RS20325 ENOG4105CSH Transporter FLM33_RS20345 ENOG4107YNJ LysR family Transcriptional regulator FLM33_RS20350 ENOG4108IV0 ABC, transporter FLM33_RS20355 ENOG4105C0Z ABC transporter FLM33_RS20360 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FLM33_RS20365 ENOG4105C32 Amino acid ABC transporter (Permease) FLM33_RS20380 ENOG4105C6N Formate acetyltransferase FLM33_RS20390 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) FLM33_RS20395 ENOG4105C7B Threonine dehydratase FLM33_RS20400 ENOG410811B TRANSCRIPTIONal FLM33_RS20455 ENOG4105E0K tonB-dependent siderophore receptor FLM33_RS20460 ENOG4106JQ5 Transglycosylase SLT domain FLM33_RS20465 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FLM33_RS20470 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FLM33_RS20480 ENOG4105MWK D-amino acid dehydrogenase, small subunit FLM33_RS20490 ENOG4105ED1 spovr family FLM33_RS20495 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FLM33_RS20500 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FLM33_RS20505 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FLM33_RS20515 ENOG4108ZZ3 UPF0260 protein FLM33_RS20520 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FLM33_RS20525 ENOG4105VNG YcgL domain-containing protein FLM33_RS20530 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FLM33_RS20535 ENOG4107QMS site-determining protein FLM33_RS20540 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FLM33_RS20545 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FLM33_RS20550 ENOG4105CEY Amp-dependent synthetase and ligase FLM33_RS20555 ENOG4105Y4Z Outer Membrane Lipoprotein FLM33_RS20560 ENOG41072GX Peptidase M22 Glycoprotease FLM33_RS20565 ENOG4105DVT helicase FLM33_RS20570 ENOG4105M4H endoribonuclease L-psp FLM33_RS20575 ENOG4105X5C UPF0181 protein FLM33_RS20585 ENOG4105P8F nudix hydrolase FLM33_RS20590 ENOG4105EJQ L-serine dehydratase FLM33_RS20595 ENOG4107XTP (EAL) domain protein FLM33_RS20600 ENOG4105EE5 Membrane protein terC FLM33_RS20605 ENOG4105DAS pts system FLM33_RS20610 ENOG4105ETZ PTS System FLM33_RS20615 ENOG4105F3R pts system mannose fructose sorbose family iid FLM33_RS20620 ENOG4108NK4 UPF0266 membrane protein FLM33_RS20625 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) FLM33_RS20630 ENOG4105DHI Methyltransferase FLM33_RS20635 ENOG4105CJN penicillin-binding protein FLM33_RS20650 ENOG4105Q3Y exported protein FLM33_RS20660 ENOG4105TIK FLM33_RS20665 ENOG4105J4Q Transcriptional regulator FLM33_RS20670 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLM33_RS20675 ENOG4105D0M Protease HtpX homolog FLM33_RS20680 ENOG4105CN1 protease FLM33_RS20685 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FLM33_RS20690 ENOG4108ZGC gaf domain protein FLM33_RS20695 ENOG4105H2K paraquat-inducible protein a FLM33_RS20700 ENOG4105DY2 Paraquat-inducible protein b FLM33_RS20705 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FLM33_RS20710 ENOG4105WT8 Protein of unknown function (DUF1480) FLM33_RS20715 ENOG4105UVW uncharacterized protein yebW FLM33_RS20720 ENOG4108R1E Serine threonine protein phosphatase 1 FLM33_RS20725 ENOG4108MJ5 VirK protein FLM33_RS20735 ENOG4105NKT exported protein FLM33_RS20740 ENOG4108PNC copper resistance FLM33_RS20745 ENOG4105FXM Copper resistance protein FLM33_RS20750 ENOG4105MPK DNA polymerase III subunit theta FLM33_RS20755 ENOG4105UMD exodeoxyribonuclease X FLM33_RS20760 ENOG4105CUG Oligopeptidase b FLM33_RS20765 ENOG4108Q2J Inner membrane protein YebE FLM33_RS20770 ENOG4105X2V dna damage-inducible protein FLM33_RS20780 ENOG4108UHU Aldolase FLM33_RS20785 ENOG4105C01 Dihydroxy-acid dehydratase FLM33_RS20790 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FLM33_RS20800 ENOG4106KNT transcriptional regulator FLM33_RS20805 ENOG4105CA9 Pyruvate kinase FLM33_RS20810 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FLM33_RS20815 ENOG4105DR5 peptidase FLM33_RS20820 ENOG4105NXV High-affinity zinc uptake system protein FLM33_RS20830 ENOG4105FAV ABC, transporter FLM33_RS20835 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FLM33_RS20840 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FLM33_RS20845 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FLM33_RS20850 ENOG4105CDY transcriptional regulatory protein FLM33_RS20855 ENOG4108TIT dATP pyrophosphohydrolase FLM33_RS20860 ENOG4105C9M aspartyl-trna synthetase FLM33_RS20865 ENOG4105D3W isochorismatase FLM33_RS20870 ENOG41081XQ Conserved Protein FLM33_RS20875 ENOG4105WJG Glutathione FLM33_RS20880 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FLM33_RS20885 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FLM33_RS20890 ENOG4106N3A copper homeostasis protein cutc FLM33_RS20895 ENOG4106ZCM YecM protein FLM33_RS20900 ENOG4105C75 arginyL-tRNA synthetase FLM33_RS20905 ENOG4105F5H Glycosyl Hydrolase Family 88 FLM33_RS20910 ENOG4105CT4 transporter FLM33_RS20915 ENOG4108VA4 Universal stress protein FLM33_RS20920 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FLM33_RS20930 ENOG4105CNN ABC, transporter FLM33_RS20940 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FLM33_RS20950 ENOG4108UEC Ferritin-like protein FLM33_RS20965 ENOG4105N4N Protein of unknown function (DUF2766) FLM33_RS20970 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLM33_RS20985 ENOG41090A1 ferritin FLM33_RS20990 ENOG4105VVZ metal-binding protein FLM33_RS20995 ENOG4105E0U tyrosine-specific transport protein FLM33_RS21000 ENOG4106RHG Yeca family FLM33_RS21035 ENOG4105WH1 Two component transcriptional regulator luxr family FLM33_RS21040 ENOG4105XVG cytoplasmic protein FLM33_RS21045 ENOG4105VJY transcriptional regulator FLM33_RS21050 ENOG4105CDA abc transporter atp-binding protein FLM33_RS21055 ENOG4105E5Q amino acid AbC transporter FLM33_RS21060 ENOG4105K6H D-cysteine desulfhydrase FLM33_RS21065 ENOG4105EAB amino acid AbC transporter FLM33_RS21070 ENOG4105E5K Alpha-amylase FLM33_RS21075 ENOG4105JCU Inherit from NOG: (Lipo)protein FLM33_RS21090 ENOG4105YX3 cellular response to acidity FLM33_RS21100 ENOG4105CKW Inner membrane protein yedI FLM33_RS21105 ENOG4105FDR Membrane FLM33_RS21110 ENOG41090BB DNA mismatch endonuclease (vsr) FLM33_RS21115 ENOG4105DVF Cytosine-specific methyltransferase FLM33_RS21120 ENOG4105EST Metal Dependent Phosphohydrolase FLM33_RS21125 ENOG4105Y0K Inner membrane protein YedR FLM33_RS21130 ENOG4105FCK Membrane FLM33_RS21140 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FLM33_RS21150 ENOG4108UQ8 endoribonuclease L-psp FLM33_RS21160 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FLM33_RS21165 ENOG4107R11 Transcriptional regulator FLM33_RS21180 ENOG4105EEQ Na H antiporter FLM33_RS21185 ENOG4108WUH Transcriptional regulator, TetR family FLM33_RS21190 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FLM33_RS21210 ENOG4105FYV Amp nucleosidase FLM33_RS21285 ENOG4105W5Q DNA repair protein (RadC FLM33_RS21330 ENOG4108PCE TRANSFER protein FLM33_RS21360 ENOG4106D0Q Type IV secretion system protein VirB2 FLM33_RS21405 ENOG4107ZSV Receptor FLM33_RS21410 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FLM33_RS21430 ENOG4105C0W non-ribosomal peptide synthetase FLM33_RS21445 ENOG4105BZ1 (ABC) transporter FLM33_RS21450 ENOG4105EYM Major Facilitator superfamily FLM33_RS21470 ENOG4105UQX Mate efflux family protein FLM33_RS21505 ENOG4105BZU Histidine kinase FLM33_RS21520 ENOG4105ETT transcriptional Regulator, LysR family FLM33_RS21525 ENOG4105YP6 Domain of unknown function (DUF1869) FLM33_RS21530 ENOG4108YS1 cytoplasmic protein FLM33_RS21540 ENOG4105BZU Histidine kinase FLM33_RS21550 ENOG4105CSH Transporter FLM33_RS21555 ENOG4108KMH lipoate-protein ligase a FLM33_RS21560 ENOG4105HEI LysR family (Transcriptional regulator FLM33_RS21565 ENOG41090U3 tautomerase FLM33_RS21575 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FLM33_RS21580 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FLM33_RS21585 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FLM33_RS21590 ENOG41090HJ UPF0265 protein FLM33_RS21595 ENOG4105DR8 Membrane FLM33_RS21605 ENOG4105EKQ RNA-directed DNA polymerase FLM33_RS21610 ENOG4105DZ1 carboxypeptidase FLM33_RS21615 ENOG4105CJB Exodeoxyribonuclease I FLM33_RS21625 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FLM33_RS21630 ENOG4105YVS arsR family transcriptional regulator FLM33_RS21635 ENOG4105CUB amino acid FLM33_RS21645 ENOG4105EQ1 Transcriptional regulator FLM33_RS21650 ENOG4107SRH Nad-dependent epimerase dehydratase FLM33_RS21660 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FLM33_RS21670 ENOG4105CIH Imidazole acetol-phosphate transaminase FLM33_RS21675 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FLM33_RS21680 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FLM33_RS21690 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FLM33_RS21695 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FLM33_RS21720 ENOG4105CPK Glycosyl transferase (Group 1 FLM33_RS21765 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FLM33_RS21775 ENOG4108MRJ FLM33_RS21785 ENOG4105MH5 phosphoesterase PA-phosphatase related protein FLM33_RS21790 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FLM33_RS21795 ENOG4105EE5 Membrane protein terC FLM33_RS21800 ENOG4108GAE asmA family FLM33_RS21805 ENOG4105DHP deoxycytidine triphosphate deaminase FLM33_RS21810 ENOG4105DBI uridine monophosphokinase FLM33_RS21815 ENOG4105D03 DNA-3-methyladenine glycosylase II FLM33_RS21820 ENOG4105R8A Heat shock protein FLM33_RS21825 ENOG4105BZU Histidine kinase FLM33_RS21845 ENOG4105CK2 sodium dicarboxylate symporter FLM33_RS21850 ENOG4105ENT Efflux transporter rnd family, mfp subunit FLM33_RS21855 ENOG4105BZS acriflavin resistance protein FLM33_RS21860 ENOG4105BZS acriflavin resistance protein FLM33_RS21865 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLM33_RS21870 ENOG4105EB3 Histidine kinase FLM33_RS21875 ENOG4105E3W Two component transcriptional regulator (Winged helix family FLM33_RS21880 ENOG4105CFP Peptidase U32 FLM33_RS21890 ENOG4108JQ7 (ABC) transporter FLM33_RS21900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLM33_RS21905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLM33_RS21910 ENOG4105DEF Extracellular solute-binding protein, family 5 FLM33_RS21915 ENOG4105CXK mandelate racemase muconate lactonizing FLM33_RS21920 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FLM33_RS21930 ENOG4105CMG Carbohydrate kinase FLM33_RS21935 ENOG4105DEI Mannitol dehydrogenase FLM33_RS21960 ENOG4105IE8 Alpha-ketoglutarate permease FLM33_RS21965 ENOG4105EIE fructose-bisphosphate aldolase FLM33_RS21970 ENOG4105DWF phosphomethylpyrimidine kinase FLM33_RS21985 ENOG4105DUM transcriptional regulator, lysR family FLM33_RS21990 ENOG4105CPN adenine deaminase FLM33_RS21995 ENOG4105C7N Xanthine uracil vitamin C permease FLM33_RS22000 ENOG4105EJC lysr family transcriptional regulator FLM33_RS22005 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly FLM33_RS22015 ENOG4105D1F ATP-binding protein FLM33_RS22020 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FLM33_RS22025 ENOG4108W15 Protein of unknown function (DUF1456) FLM33_RS22030 ENOG4108NEV two component transcriptional regulator, LytTR family FLM33_RS22035 ENOG4108HRK Histidine kinase FLM33_RS22045 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FLM33_RS22050 ENOG4108IJ8 ABC transporter FLM33_RS22055 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FLM33_RS22060 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FLM33_RS22065 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FLM33_RS22070 ENOG4105CXG d-lactate dehydrogenase FLM33_RS22080 ENOG41061WM D-Alanyl-D-Alanine FLM33_RS22085 ENOG41069YE inner membrane protein yohC FLM33_RS22090 ENOG4105KHU inner membrane protein YohD FLM33_RS22100 ENOG4105CS2 ec 3.2.1.21 FLM33_RS22115 ENOG4105TW1 Carbohydrate-selective porin OprB FLM33_RS22120 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FLM33_RS22125 ENOG4105VAW lrga family FLM33_RS22130 ENOG41067MG lrgb family FLM33_RS22135 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FLM33_RS22140 ENOG4107GZ4 SanA protein FLM33_RS22145 ENOG4107SDZ Galactoside transport system permease protein mglC FLM33_RS22150 ENOG4105C2J ABC transporter FLM33_RS22160 ENOG41060NJ transcriptional regulator FLM33_RS22165 ENOG4105DHF Membrane FLM33_RS22170 ENOG4105EUJ GTP cyclohydrolase i FLM33_RS22180 ENOG4105D05 Receptor FLM33_RS22185 ENOG4108IQI permease FLM33_RS22190 ENOG4105DUM transcriptional regulator, lysR family FLM33_RS22195 ENOG4105HMI Membrane FLM33_RS22200 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FLM33_RS22205 ENOG4105DM4 PTS System FLM33_RS22210 ENOG4105DE4 1-phosphofructokinase FLM33_RS22215 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FLM33_RS22220 ENOG4105S8Q sugar efflux transporter FLM33_RS22230 ENOG4105KRS Proteinase inhibitor FLM33_RS22240 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FLM33_RS22245 ENOG4105DEI Mannitol dehydrogenase FLM33_RS22250 ENOG4105CKI cobalamin synthesis protein FLM33_RS22255 ENOG41076MN Phosphoesterase, PA-phosphatase related FLM33_RS22260 ENOG4107TT5 NLP P60 protein FLM33_RS22265 ENOG4105CXC rtn protein FLM33_RS22270 ENOG4105E43 Extracellular solute-binding protein, family 5 FLM33_RS22275 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FLM33_RS22280 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FLM33_RS22285 ENOG4108JQ5 ABC transporter FLM33_RS22290 ENOG4105HG6 FLM33_RS22295 ENOG4105C2C drug resistance transporter, Bcr CflA FLM33_RS22300 ENOG4105I08 Pseudouridine synthase FLM33_RS22305 ENOG4105CFI type iii restriction protein res subunit FLM33_RS22310 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FLM33_RS22325 ENOG4107VIJ nudix hydrolase FLM33_RS22330 ENOG4105N2W Transcriptional regulator FLM33_RS22335 ENOG4106V8H Nucleoid-associated protein FLM33_RS22340 ENOG4105PAN UPF0352 protein FLM33_RS22345 ENOG4105E68 Sulfatase FLM33_RS22355 ENOG4105F4G Membrane FLM33_RS22370 ENOG4105CHH sulfate transporter FLM33_RS22375 ENOG4105CJW magnesium transporter FLM33_RS22380 ENOG4105IBP Cyclic peptide transporter FLM33_RS22385 ENOG4105CF1 Alkylated DNA repair protein FLM33_RS22390 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FLM33_RS22405 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FLM33_RS22410 ENOG41068CG regulatoR FLM33_RS22415 ENOG4105BZU Histidine kinase FLM33_RS22420 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLM33_RS22425 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FLM33_RS22430 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLM33_RS22435 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLM33_RS22440 ENOG4105XPH Ferredoxin FLM33_RS22445 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FLM33_RS22450 ENOG4105CXY transporter FLM33_RS22455 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FLM33_RS22460 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FLM33_RS22465 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FLM33_RS22470 ENOG4105CNV Aldolase FLM33_RS22475 ENOG4105CSP Major Facilitator Superfamily FLM33_RS22480 ENOG4105CXK mandelate racemase muconate lactonizing FLM33_RS22485 ENOG4107258 Transcriptional regulator FLM33_RS22490 ENOG4108EWA cinA-like protein FLM33_RS22495 ENOG4108UII YfaZ family FLM33_RS22500 ENOG4105DNE Transposase FLM33_RS22510 ENOG4105CEY Amp-dependent synthetase and ligase FLM33_RS22515 ENOG4105DNI Converts SHCHC to OSB (By similarity) FLM33_RS22520 ENOG4108IPT Naphthoate synthase FLM33_RS22525 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FLM33_RS22530 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FLM33_RS22535 ENOG4105E4F Isochorismate synthase FLM33_RS22540 ENOG4107YB6 acetyltransferase, (GNAT) family FLM33_RS22545 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FLM33_RS22550 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FLM33_RS22555 ENOG4105C8S subunit m FLM33_RS22560 ENOG4105D65 subunit l FLM33_RS22565 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FLM33_RS22570 ENOG4107UFS subunit j FLM33_RS22580 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FLM33_RS22585 ENOG4108IEH NADH dehydrogenase subunit g FLM33_RS22590 ENOG4107QIZ NADH dehydrogenase FLM33_RS22595 ENOG4105GKE subunit e FLM33_RS22600 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FLM33_RS22605 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FLM33_RS22610 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FLM33_RS22615 ENOG4107NQ8 LysR family Transcriptional regulator FLM33_RS22620 ENOG4105CHM Aminotransferase FLM33_RS22625 ENOG4105DK2 UPF0207 protein FLM33_RS22630 ENOG4107QWE )-transporter FLM33_RS22635 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FLM33_RS22645 ENOG4105PQ6 UPF0208 membrane protein FLM33_RS22650 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FLM33_RS22655 ENOG4105C6K Malic enzyme FLM33_RS22660 ENOG4105PTV Nudix Hydrolase FLM33_RS22665 ENOG4108RE9 Phosphodiesterase FLM33_RS22670 ENOG4108SHQ Glutathione S-transferase FLM33_RS22675 ENOG4105CYM Glutathione S-transferase FLM33_RS22680 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase FLM33_RS22685 ENOG4105ECP epimerase FLM33_RS22695 ENOG4105KNA -acetyltransferase FLM33_RS22700 ENOG4108JEH abc transporter atp-binding protein FLM33_RS22705 ENOG4106YG3 ABC transporter FLM33_RS22710 ENOG4105DSP amino acid AbC transporter FLM33_RS22715 ENOG4105E89 ABC transporter FLM33_RS22720 ENOG4105E89 ABC transporter FLM33_RS22730 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FLM33_RS22735 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FLM33_RS22740 ENOG4105E96 Colicin v production protein FLM33_RS22745 ENOG4108S3P Sporulation domain protein FLM33_RS22750 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FLM33_RS22755 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FLM33_RS22760 ENOG4105DQR SNARE associated Golgi FLM33_RS22765 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FLM33_RS22770 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FLM33_RS22780 ENOG4106WZ1 flagella biosynthesis regulator FLM33_RS22785 ENOG4105F9N Major Facilitator Superfamily FLM33_RS22790 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FLM33_RS22795 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FLM33_RS22800 ENOG4105MH2 YfcL protein FLM33_RS22805 ENOG4108BPE -transporting atpase FLM33_RS22810 ENOG4105EJ9 Membrane FLM33_RS22815 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) FLM33_RS22820 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FLM33_RS22825 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FLM33_RS22830 ENOG4108DG9 Smr protein MutS2 FLM33_RS22835 ENOG4108BY2 phosphohistidine phosphatase FLM33_RS22840 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FLM33_RS22845 ENOG4105CHU acetyl-coa acetyltransferase FLM33_RS22850 ENOG4105KZW UPF0381 protein FLM33_RS22855 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FLM33_RS22860 ENOG410903C (LipO)protein FLM33_RS22865 ENOG4105S64 Formate nitrite transporter FLM33_RS22885 ENOG4105DND Transcriptional regulator FLM33_RS22890 ENOG4107Y2X deaminase FLM33_RS22895 ENOG4105DJ2 Major Facilitator Superfamily FLM33_RS22905 ENOG4105CHM Aminotransferase FLM33_RS22920 ENOG4108HRK Histidine kinase FLM33_RS22925 ENOG4105DY9 regulatoR FLM33_RS22930 ENOG4105CHC glucokinase (EC 2.7.1.2) FLM33_RS22940 ENOG4107RA9 decarboxylase FLM33_RS22945 ENOG4105CPC Aldo Keto reductase FLM33_RS22950 ENOG4109076 Conserved Protein FLM33_RS22955 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FLM33_RS22960 ENOG4105D9N nucleoside FLM33_RS22965 ENOG4108KMM Diguanylate cyclase FLM33_RS22980 ENOG4105HZG regulatoR FLM33_RS22985 ENOG4105GXM Putative transcription regulator (DUF1323) FLM33_RS22990 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FLM33_RS23015 ENOG4108M0I Transcriptional regulator FLM33_RS23020 ENOG4105DHU Bile acid FLM33_RS23030 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FLM33_RS23035 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FLM33_RS23040 ENOG4105EXN Sulfate transport protein CysZ FLM33_RS23045 ENOG4105C6T cysteine synthase FLM33_RS23050 ENOG4105KZ7 phosphocarrier protein hpr FLM33_RS23055 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FLM33_RS23060 ENOG4105C5Y PTS System FLM33_RS23070 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FLM33_RS23075 ENOG4105CSW GntR family transcriptional regulator FLM33_RS23080 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein FLM33_RS23085 ENOG4105C6T cysteine synthase FLM33_RS23090 ENOG4108IJ6 ABC transporter FLM33_RS23095 ENOG4105ECW sulfate abc transporter FLM33_RS23100 ENOG4108I5D sulfate abc transporter FLM33_RS23105 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FLM33_RS23115 ENOG4105EZR dyp-type peroxidase family protein FLM33_RS23120 ENOG4105E7K (LipO)protein FLM33_RS23125 ENOG4105QZU Inner membrane protein YfeZ FLM33_RS23130 ENOG4108R6G acetyltransferase FLM33_RS23135 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FLM33_RS23140 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FLM33_RS23145 ENOG4108K3Z AraC family transcriptional regulator FLM33_RS23150 ENOG4108X49 Ethanolamine utilization protein EutK FLM33_RS23155 ENOG4106D67 ethanolamine utilization protein FLM33_RS23165 ENOG4105CPD ethanolamine ammonia-lyase FLM33_RS23170 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FLM33_RS23175 ENOG4105ENY Ethanolamine utilization protein eutH FLM33_RS23180 ENOG4105C0A alcohol dehydrogenase FLM33_RS23185 ENOG4107YMV ethanolamine utilization protein FLM33_RS23190 ENOG4108EKI Dehydrogenase FLM33_RS23195 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FLM33_RS23200 ENOG4105KNY Microcompartments protein FLM33_RS23205 ENOG4108IJ2 phosphate acetyltransferase FLM33_RS23210 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase FLM33_RS23215 ENOG4105NDK ethanolamine utilization protein FLM33_RS23220 ENOG4106S4J ethanolamine utilization protein EutP FLM33_RS23225 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place FLM33_RS23230 ENOG4105C6K Malic enzyme FLM33_RS23235 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FLM33_RS23240 ENOG4105CV1 Transketolase (EC 2.2.1.1) FLM33_RS23245 ENOG4108PVD exported protein FLM33_RS23250 ENOG4107VIJ nudix hydrolase FLM33_RS23255 ENOG4105BZ8 glutamate synthase FLM33_RS23260 ENOG4105BZS acriflavin resistance protein FLM33_RS23270 ENOG4105KUZ arsenate reductase FLM33_RS23275 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FLM33_RS23280 ENOG4105XYK UPF0370 protein FLM33_RS23285 ENOG4106KED esterase YpfH FLM33_RS23290 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FLM33_RS23295 ENOG4105CGZ zinc metallopeptidase FLM33_RS23300 ENOG4105C8V SAICAR synthetase FLM33_RS23305 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FLM33_RS23310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FLM33_RS23315 ENOG4105RH4 Glycine cleavage system transcriptional repressor FLM33_RS23320 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLM33_RS23325 ENOG4105C02 permease FLM33_RS23335 ENOG4105ERG peptidase m48, ste24p FLM33_RS23340 ENOG4105K89 arsenate reductase FLM33_RS23350 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FLM33_RS23355 ENOG4105C2W permease FLM33_RS23360 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FLM33_RS23365 ENOG4105CS2 ec 3.2.1.21 FLM33_RS23370 ENOG41066F8 ROK family FLM33_RS23375 ENOG4105CXB phosphoribosylaminoimidazole synthetase FLM33_RS23380 ENOG4108V3E phosphoribosylglycinamide formyltransferase FLM33_RS23385 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FLM33_RS23390 ENOG4105C9X ppx gppa phosphatase FLM33_RS23395 ENOG4105BZU Histidine kinase FLM33_RS23400 ENOG41062G3 Protein of unknown function (DUF2633) FLM33_RS23415 ENOG4105C4X radical SAM domain protein FLM33_RS23425 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FLM33_RS23430 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FLM33_RS23435 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FLM33_RS23440 ENOG4105VPD cellular component movement FLM33_RS23450 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FLM33_RS23455 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FLM33_RS23460 ENOG4105N21 Membrane FLM33_RS23470 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FLM33_RS23475 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FLM33_RS23480 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FLM33_RS23485 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FLM33_RS23490 ENOG4108JQB penicillin-binding protein 1C FLM33_RS23495 ENOG4105DN3 alpha-2-macroglobulin domain protein FLM33_RS23500 ENOG4105KHC sulfurtransferase FLM33_RS23510 ENOG4105YYA enhanced serine sensitivity protein SseB FLM33_RS23515 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FLM33_RS23520 ENOG4105WVQ Fe-S assembly protein IscX FLM33_RS23525 ENOG4108ZIT Ferredoxin, 2FE-2S FLM33_RS23530 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FLM33_RS23535 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FLM33_RS23540 ENOG4108Z4V iron-sulfur cluster assembly FLM33_RS23545 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FLM33_RS23550 ENOG4105C3J Cysteine desulfurase FLM33_RS23555 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FLM33_RS23560 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FLM33_RS23565 ENOG4105ECY inositol monophosphatase FLM33_RS23575 ENOG4105D7X high-affinity nickel-transporter FLM33_RS23580 ENOG41065CD Exported protein FLM33_RS23585 ENOG4108MN2 Stationary phase inducible protein CsiE FLM33_RS23590 ENOG4105D8G Major Facilitator superfamily FLM33_RS23595 ENOG4108ZKT aldose 1-epimerase FLM33_RS23600 ENOG4107QNK )-transporter FLM33_RS23605 ENOG4107HQ7 repeat protein FLM33_RS23610 ENOG4108NZE NAGC-like transcriptional regulator FLM33_RS23615 ENOG4108SB3 DoxX Family FLM33_RS23620 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FLM33_RS23625 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FLM33_RS23630 ENOG4108YZA Nitrogen regulatory protein pii FLM33_RS23635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FLM33_RS23640 ENOG4108SKK alpha helix protein FLM33_RS23645 ENOG4107WP9 Histidine kinase FLM33_RS23650 ENOG4108ETH Formylglycinamide ribotide synthetase FLM33_RS23655 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FLM33_RS23660 ENOG4108Z6B deaminase FLM33_RS23665 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FLM33_RS23670 ENOG4106G6Q Transcriptional regulator FLM33_RS23675 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FLM33_RS23680 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FLM33_RS23685 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FLM33_RS23690 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FLM33_RS23695 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FLM33_RS23700 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FLM33_RS23705 ENOG4105C3F Signal peptidase i FLM33_RS23710 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FLM33_RS23715 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FLM33_RS23720 ENOG4105VQK sigma E regulatory protein, MucB RseB FLM33_RS23725 ENOG41069PW sigma-e factor negative regulatory protein FLM33_RS23740 ENOG4108IYU L-aspartate oxidase FLM33_RS23745 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FLM33_RS23750 ENOG4105C1J atp-dependent rna helicase FLM33_RS23755 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) FLM33_RS23760 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FLM33_RS23765 ENOG4105EIB trna rrna methyltransferase FLM33_RS23770 ENOG4105K63 Thioredoxin FLM33_RS23775 ENOG4106IUH DTW domain containing protein FLM33_RS23780 ENOG4105CD5 CoA-binding domain protein FLM33_RS23785 ENOG4105JIM Phosphatidylserine synthase FLM33_RS23790 ENOG4105T42 (LipO)protein FLM33_RS23795 ENOG4105CSH Transporter FLM33_RS23820 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FLM33_RS23825 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FLM33_RS23830 ENOG4105C34 Pseudouridine synthase FLM33_RS23835 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FLM33_RS23840 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FLM33_RS23850 ENOG4105CQC Prephenate dehydratase FLM33_RS23860 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FLM33_RS23865 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FLM33_RS23870 ENOG4108WS1 FLM33_RS23875 ENOG4108KHX Diguanylate cyclase FLM33_RS23880 ENOG41090EK ompa motb domain protein FLM33_RS23895 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FLM33_RS23900 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FLM33_RS23905 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FLM33_RS23910 ENOG4105K5M 30s ribosomal protein S16 FLM33_RS23915 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FLM33_RS23920 ENOG4106KVJ cytochrome C assembly protein FLM33_RS23925 ENOG4108JU6 CBS domain protein FLM33_RS23930 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FLM33_RS23935 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FLM33_RS23940 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FLM33_RS23945 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FLM33_RS23955 ENOG4108Z1B Cyclase dehydrase FLM33_RS23960 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FLM33_RS23990 ENOG4105UEI Transcriptional Regulator AraC Family FLM33_RS23995 ENOG4105C1P efflux transporter, rnd family, mfp subunit FLM33_RS24010 ENOG4105EVZ LysR family transcriptional regulator FLM33_RS24015 ENOG4105CYW agmatinase FLM33_RS24030 ENOG4106TNF Periplasmic binding protein FLM33_RS24040 ENOG4105MP9 class II Aldolase FLM33_RS24045 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FLM33_RS24050 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FLM33_RS24065 ENOG4108WQH regulatoR FLM33_RS24070 ENOG4106EAR Fimbrial protein FLM33_RS24075 ENOG4106P2F Pfam:Pili_assembly_C FLM33_RS24080 ENOG4105CW0 outer membrane usher protein FLM33_RS24095 ENOG4105CW0 outer membrane usher protein FLM33_RS24100 ENOG4108VCD Chaperone FLM33_RS24105 ENOG4105X0I Fimbrial FLM33_RS24110 ENOG4105C26 Dehydrogenase FLM33_RS24115 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FLM33_RS24120 ENOG4105CC0 LysR family Transcriptional regulator FLM33_RS24130 ENOG41080HT Transcriptional regulator, arsr family FLM33_RS24150 ENOG4108X73 DNA- binding protein FLM33_RS24155 ENOG4108RNS Exports L-alanine (By similarity) FLM33_RS24160 ENOG4108WMJ Protein of unknown function (DUF2002) FLM33_RS24165 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) FLM33_RS24170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLM33_RS24175 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FLM33_RS24180 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FLM33_RS24185 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FLM33_RS24190 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLM33_RS24195 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLM33_RS24200 ENOG4108IJ7 Glycine betaine FLM33_RS24205 ENOG4108HQS Glycine betaine FLM33_RS24210 ENOG4105GIJ Glycine betaine FLM33_RS24215 ENOG4108UMN azlc family FLM33_RS24220 ENOG4105ZED uncharacterized protein ygaH FLM33_RS24225 ENOG4105NTK Transcriptional repressor Mpra FLM33_RS24230 ENOG4105CW7 secretion protein, HlyD family FLM33_RS24235 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLM33_RS24240 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FLM33_RS24255 ENOG4105D9M gamma-glutamylcysteine synthetase FLM33_RS24260 ENOG4105W39 Membrane FLM33_RS24265 ENOG4107VXZ Hydrolase FLM33_RS24270 ENOG4105K3G Periplasmic Protein FLM33_RS24300 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FLM33_RS24305 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FLM33_RS24310 ENOG4105Y3E Modulates RecA activity (By similarity) FLM33_RS24315 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FLM33_RS24320 ENOG4107TH8 cina domain protein FLM33_RS24330 ENOG4105CC5 ABC transporter FLM33_RS24340 ENOG4105CVE Lytic murein transglycosylase FLM33_RS24345 ENOG410787A Pts system, glucitol sorbitol-specific FLM33_RS24350 ENOG4105DZY Pts system, glucitol sorbitol-specific FLM33_RS24355 ENOG4105VI0 Pts system, glucitol sorbitol-specific FLM33_RS24360 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FLM33_RS24365 ENOG4105J92 DNA-binding transcriptional activator GutM FLM33_RS24370 ENOG410804X Transcriptional regulator FLM33_RS24380 ENOG4108JUA Transcriptional regulator FLM33_RS24385 ENOG4105CNW domain protein FLM33_RS24390 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FLM33_RS24400 ENOG4105C8H hydrogenase maturation protein Hypf FLM33_RS24405 ENOG4108RC0 Electron transport protein FLM33_RS24410 ENOG4105DDV Transcriptional regulator (LacI family FLM33_RS24415 ENOG4105C5Y PTS System