locus-tag	class	description
AM445_RS00005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM445_RS00015	COG1120	ATPase activity
AM445_RS00020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS00025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM445_RS00030	COG1414	Transcriptional regulator
AM445_RS00065	COG2814	Major facilitator Superfamily
AM445_RS00085	COG0583	DNA-binding transcription factor activity
AM445_RS00090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM445_RS00110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM445_RS00115	COG1116	anion transmembrane transporter activity
AM445_RS00120	COG4774	siderophore transport
AM445_RS00125	COG1120	ATPase activity
AM445_RS00130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS00135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS00155	COG0765	amino acid transport
AM445_RS00160	COG1126	abc transporter atp-binding protein
AM445_RS00190	COG1473	amidohydrolase
AM445_RS00195	COG3383	formate dehydrogenase (NAD+) activity
AM445_RS00200	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AM445_RS00215	COG1175	transmembrane transport
AM445_RS00250	COG1857	crispr-associated protein
AM445_RS00260	COG1518	maintenance of DNA repeat elements
AM445_RS00265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM445_RS00275	COG3157	Type VI secretion system effector, Hcp
AM445_RS00305	COG4133	protoheme IX ABC transporter activity
AM445_RS00310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM445_RS00315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM445_RS00330	COG1138	Cytochrome C-type biogenesis protein
AM445_RS00335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM445_RS00340	COG4235	cytochrome complex assembly
AM445_RS00340	COG3088	subunit of a heme lyase
AM445_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS00395	COG2610	gluconate transmembrane transporter activity
AM445_RS00400	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM445_RS00410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM445_RS00420	COG0583	DNA-binding transcription factor activity
AM445_RS00440	COG0277	FAD linked oxidase domain protein
AM445_RS00445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM445_RS00470	COG0402	S-adenosylhomocysteine deaminase activity
AM445_RS00595	COG2814	Major facilitator Superfamily
AM445_RS00600	COG1082	Xylose isomerase domain protein TIM barrel
AM445_RS00610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM445_RS00640	COG4608	Belongs to the ABC transporter superfamily
AM445_RS00645	COG0444	Belongs to the ABC transporter superfamily
AM445_RS00670	COG0346	lactoylglutathione lyase activity
AM445_RS00675	COG1349	DNA-binding transcription factor activity
AM445_RS00705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AM445_RS00725	COG0300	oxidoreductase activity
AM445_RS00770	COG0307	riboflavin synthase, alpha
AM445_RS00775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM445_RS00780	COG2814	Major facilitator Superfamily
AM445_RS00785	COG0583	DNA-binding transcription factor activity
AM445_RS00800	COG2814	Major facilitator Superfamily
AM445_RS00815	COG0791	NLP P60 protein
AM445_RS00820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM445_RS00830	COG0346	lactoylglutathione lyase activity
AM445_RS00835	COG1902	pentaerythritol trinitrate reductase activity
AM445_RS00840	COG1309	transcriptional regulator
AM445_RS00845	COG3313	Fe-S protein
AM445_RS00850	COG4989	oxidoreductase activity
AM445_RS00855	COG2032	superoxide dismutase activity
AM445_RS00860	COG1289	transmembrane transporter activity
AM445_RS00865	COG1566	PFAM secretion protein HlyD family protein
AM445_RS00895	COG3895	Periplasmic Protein
AM445_RS00910	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AM445_RS00915	COG0625	glutathione transferase activity
AM445_RS00930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM445_RS00940	COG4659	FMN binding
AM445_RS00975	COG2723	6-phospho-beta-galactosidase activity
AM445_RS00985	COG0673	inositol 2-dehydrogenase activity
AM445_RS00995	COG2814	Major facilitator Superfamily
AM445_RS01015	COG3038	cytochrome b561
AM445_RS01035	COG0583	DNA-binding transcription factor activity
AM445_RS01040	COG3485	protocatechuate 3,4-dioxygenase
AM445_RS01045	COG3485	protocatechuate 3,4-dioxygenase
AM445_RS01050	COG5383	Protein conserved in bacteria
AM445_RS01055	COG2272	Belongs to the type-B carboxylesterase lipase family
AM445_RS01070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM445_RS01075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM445_RS01080	COG1275	C4-dicarboxylate transporter malic acid transport protein
AM445_RS01085	COG0500	methyltransferase
AM445_RS01095	COG0697	spore germination
AM445_RS01100	COG2207	Transcriptional regulator
AM445_RS01100	COG3708	Transcriptional regulator
AM445_RS01105	COG3135	benzoate transporter
AM445_RS01110	COG1396	sequence-specific DNA binding
AM445_RS01120	COG0826	peptidase U32
AM445_RS01140	COG1294	oxidase, subunit
AM445_RS01145	COG1271	oxidase subunit
AM445_RS01150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM445_RS01155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM445_RS01160	COG3842	ATPase activity
AM445_RS01165	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM445_RS01170	COG1177	transmembrane transport
AM445_RS01175	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS01205	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS01210	COG0747	negative chemotaxis
AM445_RS01220	COG3238	Protein conserved in bacteria
AM445_RS01225	COG1247	-acetyltransferase
AM445_RS01235	COG2130	NADP-dependent
AM445_RS01250	COG3691	Protein conserved in bacteria
AM445_RS01255	COG1228	amidohydrolase
AM445_RS01260	COG4772	TonB-dependent receptor
AM445_RS01285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AM445_RS01290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM445_RS01295	COG1473	amidohydrolase
AM445_RS01300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM445_RS01305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS01315	COG0765	amino acid transport
AM445_RS01320	COG1126	abc transporter atp-binding protein
AM445_RS01330	COG0625	glutathione transferase activity
AM445_RS01360	COG2211	Major facilitator Superfamily
AM445_RS01375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM445_RS01380	COG3842	ATPase activity
AM445_RS01385	COG1840	ABC-type Fe3 transport system, periplasmic component
AM445_RS01390	COG1178	ABC-type Fe3 transport system permease component
AM445_RS01395	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AM445_RS01400	COG2181	nitrate reductase activity
AM445_RS01405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AM445_RS01410	COG1140	nitrate reductase beta subunit
AM445_RS01415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AM445_RS01435	COG1414	Transcriptional regulator
AM445_RS01440	COG4948	Mandelate Racemase Muconate Lactonizing
AM445_RS01445	COG4829	muconolactone delta-isomerase
AM445_RS01450	COG3485	protocatechuate 3,4-dioxygenase
AM445_RS01460	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM445_RS01480	COG0243	molybdopterin cofactor binding
AM445_RS01480	COG3383	formate dehydrogenase (NAD+) activity
AM445_RS01485	COG0243	molybdopterin cofactor binding
AM445_RS01485	COG3383	formate dehydrogenase (NAD+) activity
AM445_RS01490	COG0437	4 iron, 4 sulfur cluster binding
AM445_RS01495	COG2864	formate dehydrogenase
AM445_RS01510	COG2326	polyphosphate kinase activity
AM445_RS01520	COG2814	Major facilitator Superfamily
AM445_RS01530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM445_RS01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS01550	COG0747	negative chemotaxis
AM445_RS01555	COG1064	alcohol dehydrogenase
AM445_RS01570	COG0488	(ABC) transporter
AM445_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS01610	COG3729	General stress protein
AM445_RS01630	COG3685	Protein conserved in bacteria
AM445_RS01640	COG0366	Alpha amylase catalytic
AM445_RS01650	COG2323	membrane
AM445_RS01660	COG3111	PFAM Bacterial OB fold (BOF) protein
AM445_RS01665	COG1764	response to oxidative stress
AM445_RS01690	COG3781	membrane
AM445_RS01695	COG0243	molybdopterin cofactor binding
AM445_RS01700	COG0583	DNA-binding transcription factor activity
AM445_RS01705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS01730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS01735	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM445_RS01740	COG2814	Major facilitator Superfamily
AM445_RS01750	COG1285	pathogenesis
AM445_RS01755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM445_RS01775	COG0519	Catalyzes the synthesis of GMP from XMP
AM445_RS01775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM445_RS01815	COG0596	Alpha beta hydrolase
AM445_RS01825	COG2205	protein histidine kinase activity
AM445_RS01840	COG0076	glutamate decarboxylase activity
AM445_RS01845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM445_RS01850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM445_RS01855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM445_RS01860	COG1116	anion transmembrane transporter activity
AM445_RS01865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM445_RS01880	COG0673	inositol 2-dehydrogenase activity
AM445_RS01890	COG1609	Transcriptional regulator
AM445_RS01895	COG3706	GGDEF domain
AM445_RS01900	COG0402	S-adenosylhomocysteine deaminase activity
AM445_RS01905	COG1953	Uracil, thiamine, allantoin
AM445_RS01940	COG0596	Alpha beta hydrolase
AM445_RS01955	COG2207	Transcriptional regulator
AM445_RS01970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM445_RS01990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM445_RS02035	COG0765	amino acid transport
AM445_RS02045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM445_RS02055	COG2070	2-Nitropropane dioxygenase
AM445_RS02060	COG0583	DNA-binding transcription factor activity
AM445_RS02070	COG1902	pentaerythritol trinitrate reductase activity
AM445_RS02075	COG4529	Protein conserved in bacteria
AM445_RS02080	COG0477	Major facilitator Superfamily
AM445_RS02110	COG2223	nitrite transmembrane transporter activity
AM445_RS02120	COG1609	Transcriptional regulator
AM445_RS02125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS02135	COG3037	sugar-specific permease SgaT UlaA
AM445_RS02140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM445_RS02150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS02155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS02155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS02155	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM445_RS02170	COG0583	DNA-binding transcription factor activity
AM445_RS02175	COG0583	DNA-binding transcription factor activity
AM445_RS02180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM445_RS02190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM445_RS02205	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS02215	COG1609	Transcriptional regulator
AM445_RS02245	COG1652	LysM domain
AM445_RS02275	COG0456	acetyltransferase
AM445_RS02275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AM445_RS02285	COG0667	Aldo Keto reductase
AM445_RS02290	COG0667	Aldo Keto reductase
AM445_RS02295	COG3386	PFAM SMP-30 Gluconolaconase
AM445_RS02300	COG0667	Aldo Keto reductase
AM445_RS02330	COG0251	oxidation-reduction process
AM445_RS02335	COG0583	DNA-binding transcription factor activity
AM445_RS02340	COG0626	cystathionine gamma-synthase activity
AM445_RS02345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM445_RS02350	COG0814	amino acid
AM445_RS02355	COG0583	DNA-binding transcription factor activity
AM445_RS02365	COG1294	oxidase, subunit
AM445_RS02370	COG1271	oxidase subunit
AM445_RS02380	COG3118	belongs to the thioredoxin family
AM445_RS02410	COG0583	DNA-binding transcription factor activity
AM445_RS02450	COG1929	Belongs to the glycerate kinase type-1 family
AM445_RS02455	COG3835	regulator
AM445_RS02465	COG0583	DNA-binding transcription factor activity
AM445_RS02475	COG2186	Transcriptional regulator
AM445_RS02480	COG1263	PTS System
AM445_RS02480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM445_RS02490	COG2814	Major facilitator Superfamily
AM445_RS02495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS02495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS02515	COG2819	hydrolase of the alpha beta superfamily
AM445_RS02520	COG3300	MHYT domain
AM445_RS02520	COG5001	Diguanylate cyclase
AM445_RS02555	COG3188	usher protein
AM445_RS02570	COG1649	PFAM Uncharacterised BCR, COG1649
AM445_RS02575	COG3550	peptidyl-serine autophosphorylation
AM445_RS02580	COG1396	sequence-specific DNA binding
AM445_RS02585	COG2351	hydroxyisourate hydrolase activity
AM445_RS02590	COG3195	allantoin biosynthetic process
AM445_RS02590	COG3648	Uricase
AM445_RS02595	COG2233	PERMEase
AM445_RS02625	COG2207	Transcriptional regulator
AM445_RS02640	COG4628	conserved protein (DUF2132)
AM445_RS02660	COG2011	ABC-type metal ion transport system permease component
AM445_RS02665	COG2070	2-Nitropropane dioxygenase
AM445_RS02675	COG0477	Major facilitator Superfamily
AM445_RS02750	COG2199	diguanylate cyclase activity
AM445_RS02765	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS02770	COG0583	DNA-binding transcription factor activity
AM445_RS02780	COG0039	L-malate dehydrogenase activity
AM445_RS02785	COG1349	DNA-binding transcription factor activity
AM445_RS02790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM445_RS02795	COG3395	kinase activity
AM445_RS02805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM445_RS02810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM445_RS02815	COG2271	Major facilitator Superfamily
AM445_RS02840	COG4977	sequence-specific DNA binding
AM445_RS02850	COG0697	spore germination
AM445_RS02855	COG2814	Major facilitator Superfamily
AM445_RS02885	COG0683	leucine binding
AM445_RS02890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM445_RS02925	COG2223	nitrite transmembrane transporter activity
AM445_RS02930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM445_RS02945	COG1349	DNA-binding transcription factor activity
AM445_RS02950	COG2084	Dehydrogenase
AM445_RS02955	COG3395	kinase activity
AM445_RS02960	COG0235	Class ii aldolase
AM445_RS02965	COG3622	Belongs to the hyi family
AM445_RS02970	COG2610	gluconate transmembrane transporter activity
AM445_RS02975	COG2207	Transcriptional regulator
AM445_RS02975	COG3708	Transcriptional regulator
AM445_RS02990	COG2200	EAL domain
AM445_RS02995	COG1546	Belongs to the CinA family
AM445_RS03000	COG0071	Belongs to the small heat shock protein (HSP20) family
AM445_RS03015	COG2197	response regulator
AM445_RS03020	COG2135	peptidase activity
AM445_RS03025	COG2207	Transcriptional regulator
AM445_RS03040	COG4221	oxidoreductase activity
AM445_RS03045	COG1802	Transcriptional regulator
AM445_RS03050	COG0589	response to stress
AM445_RS03055	COG0246	Mannitol dehydrogenase
AM445_RS03060	COG2271	Major facilitator Superfamily
AM445_RS03075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM445_RS03090	COG0243	molybdopterin cofactor binding
AM445_RS03095	COG0437	4 iron, 4 sulfur cluster binding
AM445_RS03100	COG3302	dmso reductase anchor subunit
AM445_RS03115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AM445_RS03120	COG1940	carbohydrate kinase activity
AM445_RS03125	COG0583	DNA-binding transcription factor activity
AM445_RS03130	COG2814	Major facilitator Superfamily
AM445_RS03135	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AM445_RS03145	COG3591	Belongs to the peptidase S1B family
AM445_RS03165	COG0628	permease
AM445_RS03195	COG0679	Auxin Efflux Carrier
AM445_RS03205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM445_RS03230	COG3290	protein histidine kinase activity
AM445_RS03235	COG4565	transcriptional regulatory protein
AM445_RS03260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM445_RS03260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM445_RS03280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM445_RS03285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM445_RS03295	COG0183	Belongs to the thiolase family
AM445_RS03300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM445_RS03310	COG1414	Transcriptional regulator
AM445_RS03315	COG2840	Smr protein MutS2
AM445_RS03320	COG0583	DNA-binding transcription factor activity
AM445_RS03330	COG1473	amidohydrolase
AM445_RS03335	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AM445_RS03350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM445_RS03365	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM445_RS03370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM445_RS03390	COG0531	amino acid
AM445_RS03400	COG3136	membrane protein required for alginate biosynthesis
AM445_RS03405	COG0745	RESPONSE REGULATOR receiver
AM445_RS03415	COG2205	protein histidine kinase activity
AM445_RS03425	COG0114	fumarate hydratase activity
AM445_RS03430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM445_RS03430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM445_RS03435	COG1482	cell wall glycoprotein biosynthetic process
AM445_RS03440	COG5339	Protein conserved in bacteria
AM445_RS03445	COG1609	Transcriptional regulator
AM445_RS03450	COG1263	PTS System
AM445_RS03450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM445_RS03455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AM445_RS03480	COG2391	methyltransferase activity
AM445_RS03485	COG0425	Belongs to the sulfur carrier protein TusA family
AM445_RS03490	COG5562	phage envelope protein
AM445_RS03495	COG0401	homolog of Blt101
AM445_RS03500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM445_RS03505	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS03510	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AM445_RS03515	COG0477	Major facilitator Superfamily
AM445_RS03520	COG1113	amino acid transport
AM445_RS03525	COG2988	succinylglutamate desuccinylase activity
AM445_RS03530	COG3724	N-succinylarginine dihydrolase activity
AM445_RS03535	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS03540	COG3138	arginine N-succinyltransferase
AM445_RS03545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM445_RS03550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM445_RS03555	COG0667	Aldo Keto reductase
AM445_RS03560	COG0583	DNA-binding transcription factor activity
AM445_RS03585	COG4122	O-methyltransferase activity
AM445_RS03590	COG1643	Atp-dependent helicase
AM445_RS03605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM445_RS03610	COG3327	negative regulation of DNA-templated transcription, initiation
AM445_RS03615	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AM445_RS03620	COG0183	Belongs to the thiolase family
AM445_RS03625	COG2050	protein possibly involved in aromatic compounds catabolism
AM445_RS03630	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM445_RS03635	COG1024	Enoyl-CoA hydratase
AM445_RS03640	COG1024	Enoyl-CoA hydratase
AM445_RS03645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM445_RS03650	COG2151	metal-sulfur cluster biosynthetic enzyme
AM445_RS03655	COG3396	Phenylacetate-CoA oxygenase
AM445_RS03660	COG3460	Phenylacetate-CoA oxygenase
AM445_RS03665	COG3396	Phenylacetate-CoA oxygenase
AM445_RS03670	COG2030	dehydratase
AM445_RS03670	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS03695	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS03700	COG2207	Transcriptional regulator
AM445_RS03705	COG3784	Protein of unknown function (DUF1318)
AM445_RS03715	COG2911	Protein conserved in bacteria
AM445_RS03720	COG0586	Pfam SNARE associated Golgi protein
AM445_RS03725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM445_RS03730	COG3187	Heat shock protein
AM445_RS03735	COG3042	response to heat
AM445_RS03745	COG1013	pyruvate-flavodoxin oxidoreductase activity
AM445_RS03745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AM445_RS03745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM445_RS03745	COG0674	pyruvate-flavodoxin oxidoreductase activity
AM445_RS03750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM445_RS03760	COG0589	response to stress
AM445_RS03770	COG0513	Belongs to the DEAD box helicase family
AM445_RS03795	COG1349	DNA-binding transcription factor activity
AM445_RS03800	COG0673	inositol 2-dehydrogenase activity
AM445_RS03815	COG1113	amino acid transport
AM445_RS03820	COG1522	sequence-specific DNA binding
AM445_RS03830	COG1448	Aminotransferase
AM445_RS03835	COG2011	ABC-type metal ion transport system permease component
AM445_RS03845	COG1464	Belongs to the NlpA lipoprotein family
AM445_RS03850	COG0436	Aminotransferase
AM445_RS03855	COG0604	alcohol dehydrogenase
AM445_RS03880	COG0583	DNA-binding transcription factor activity
AM445_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS03905	COG1309	transcriptional regulator
AM445_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS04030	COG2885	chlorophyll binding
AM445_RS04055	COG0693	protein deglycase activity
AM445_RS04060	COG1078	dGTPase activity
AM445_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS04070	COG0583	DNA-binding transcription factor activity
AM445_RS04130	COG5002	protein histidine kinase activity
AM445_RS04130	COG2205	protein histidine kinase activity
AM445_RS04130	COG0784	Response regulator, receiver
AM445_RS04135	COG3250	beta-galactosidase activity
AM445_RS04140	COG0656	L-ascorbic acid biosynthetic process
AM445_RS04170	COG4166	transmembrane transport
AM445_RS04175	COG2866	Carboxypeptidase
AM445_RS04180	COG4948	Mandelate Racemase Muconate Lactonizing
AM445_RS04185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AM445_RS04190	COG3180	Ammonia monooxygenase
AM445_RS04200	COG1486	melibiose metabolic process
AM445_RS04205	COG0583	DNA-binding transcription factor activity
AM445_RS04215	COG3106	COG3106 Predicted ATPase
AM445_RS04225	COG1983	PspC domain protein
AM445_RS04235	COG1842	Phage shock protein A
AM445_RS04240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AM445_RS04250	COG1473	amidohydrolase
AM445_RS04265	COG0702	epimerase
AM445_RS04280	COG4171	peptide transport system, permease
AM445_RS04295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM445_RS04305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AM445_RS04310	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM445_RS04310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM445_RS04325	COG1349	DNA-binding transcription factor activity
AM445_RS04335	COG0023	Translation Initiation Factor
AM445_RS04345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AM445_RS04350	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AM445_RS04355	COG0671	phosphoesterase, PA-phosphatase related
AM445_RS04365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM445_RS04395	COG0616	signal peptide processing
AM445_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS04410	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AM445_RS04440	COG0583	DNA-binding transcription factor activity
AM445_RS04450	COG0009	L-threonylcarbamoyladenylate synthase
AM445_RS04460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM445_RS04465	COG0512	Glutamine amidotransferase of anthranilate synthase
AM445_RS04465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM445_RS04470	COG0134	indole-3-glycerol-phosphate synthase activity
AM445_RS04470	COG0135	phosphoribosylanthranilate isomerase activity
AM445_RS04525	COG4774	siderophore transport
AM445_RS04535	COG3047	cAMP biosynthetic process
AM445_RS04540	COG0727	PFAM Uncharacterised protein family (UPF0153)
AM445_RS04570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM445_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS04580	COG1988	membrane-bound metal-dependent
AM445_RS04585	COG1823	symporter activity
AM445_RS04595	COG0753	catalase activity
AM445_RS04605	COG1486	melibiose metabolic process
AM445_RS04610	COG1917	Cupin 2, conserved barrel domain protein
AM445_RS04610	COG2169	Transcriptional regulator
AM445_RS04615	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM445_RS04620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS04625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS04630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM445_RS04640	COG0322	excinuclease ABC activity
AM445_RS04645	COG3678	ATP-independent chaperone mediated protein folding
AM445_RS04655	COG3724	N-succinylarginine dihydrolase activity
AM445_RS04665	COG3138	arginine N-succinyltransferase
AM445_RS04675	COG0708	Exodeoxyribonuclease III
AM445_RS04680	COG0398	Pfam SNARE associated Golgi protein
AM445_RS04685	COG0398	Pfam SNARE associated Golgi protein
AM445_RS04690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM445_RS04695	COG4134	Bacterial extracellular solute-binding protein
AM445_RS04700	COG4135	transport system, permease component
AM445_RS04705	COG4136	ATPase activity
AM445_RS04710	COG2897	thiosulfate sulfurtransferase activity
AM445_RS04715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM445_RS04720	COG0494	nUDIX hydrolase
AM445_RS04725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM445_RS04730	COG0604	alcohol dehydrogenase
AM445_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS04730	COG3321	synthase
AM445_RS04735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM445_RS04740	COG0709	Synthesizes selenophosphate from selenide and ATP
AM445_RS04760	COG0778	Nitroreductase
AM445_RS04765	COG0616	signal peptide processing
AM445_RS04770	COG0252	asparaginase activity
AM445_RS04775	COG1335	isochorismatase
AM445_RS04790	COG3139	Protein of unknown function (DUF1315)
AM445_RS04810	COG0656	L-ascorbic acid biosynthetic process
AM445_RS04815	COG3713	MltA-interacting MipA family protein
AM445_RS04820	COG2766	serine protein kinase
AM445_RS04835	COG0386	Belongs to the glutathione peroxidase family
AM445_RS04855	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS04860	COG0583	DNA-binding transcription factor activity
AM445_RS04865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM445_RS04870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM445_RS04875	COG3344	reverse transcriptase
AM445_RS04890	COG0859	PFAM glycosyl transferase family 9
AM445_RS04895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM445_RS04905	COG2207	Transcriptional regulator
AM445_RS04910	COG2807	transmembrane transport
AM445_RS04915	COG0504	CTP synthase activity
AM445_RS04920	COG1683	Conserved Protein
AM445_RS04925	COG3189	MarR family transcriptional regulator
AM445_RS04930	COG3042	response to heat
AM445_RS05065	COG4695	Portal protein
AM445_RS05085	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AM445_RS05130	COG4974	Belongs to the 'phage' integrase family
AM445_RS05135	COG2203	Gaf domain
AM445_RS05135	COG2199	diguanylate cyclase activity
AM445_RS05155	COG3182	Iron-regulated membrane protein
AM445_RS05165	COG1560	Kdo2-lipid A biosynthetic process
AM445_RS05180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AM445_RS05185	COG3706	GGDEF domain
AM445_RS05190	COG0583	DNA-binding transcription factor activity
AM445_RS05195	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM445_RS05220	COG1294	oxidase, subunit
AM445_RS05225	COG1271	oxidase subunit
AM445_RS05230	COG3546	catalase activity
AM445_RS05235	COG3685	Protein conserved in bacteria
AM445_RS05240	COG3685	Protein conserved in bacteria
AM445_RS05245	COG3729	General stress protein
AM445_RS05250	COG1063	alcohol dehydrogenase
AM445_RS05255	COG3813	Protein conserved in bacteria
AM445_RS05275	COG0640	Transcriptional regulator
AM445_RS05280	COG0538	isocitrate dehydrogenase activity
AM445_RS05285	COG1187	pseudouridine synthase activity
AM445_RS05305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM445_RS05325	COG2205	protein histidine kinase activity
AM445_RS05330	COG2850	peptidyl-arginine hydroxylation
AM445_RS05350	COG1177	transmembrane transport
AM445_RS05365	COG0318	PFAM AMP-dependent synthetase and ligase
AM445_RS05370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM445_RS05375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM445_RS05380	COG0698	ribose 5-phosphate isomerase
AM445_RS05395	COG3395	kinase activity
AM445_RS05410	COG2390	Transcriptional regulator
AM445_RS05420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM445_RS05430	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM445_RS05440	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM445_RS05445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM445_RS05450	COG1376	ErfK ybiS ycfS ynhG family protein
AM445_RS05450	COG1388	LysM domain
AM445_RS05460	COG1309	transcriptional regulator
AM445_RS05470	COG3134	Outer membrane lipoprotein
AM445_RS05475	COG1252	NADH dehydrogenase
AM445_RS05500	COG5633	Lipoprotein
AM445_RS05505	COG0537	adenosine 5'-monophosphoramidase activity
AM445_RS05515	COG0084	hydrolase, TatD family'
AM445_RS05520	COG0470	DNA polymerase III
AM445_RS05530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM445_RS05535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM445_RS05540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM445_RS05555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM445_RS05575	COG1399	metal-binding, possibly nucleic acid-binding protein
AM445_RS05595	COG1530	ribonuclease E activity
AM445_RS05600	COG0583	DNA-binding transcription factor activity
AM445_RS05605	COG2814	Major facilitator Superfamily
AM445_RS05625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM445_RS05675	COG1560	Kdo2-lipid A biosynthetic process
AM445_RS05695	COG5645	(Lipo)protein
AM445_RS05735	COG3381	protein complex oligomerization
AM445_RS05760	COG0583	DNA-binding transcription factor activity
AM445_RS05770	COG1335	isochorismatase
AM445_RS05780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM445_RS05785	COG1702	phosphate starvation-inducible protein PhoH
AM445_RS05805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM445_RS05815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM445_RS05835	COG1309	transcriptional regulator
AM445_RS05870	COG2233	PERMEase
AM445_RS05880	COG3729	General stress protein
AM445_RS05905	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS05920	COG0531	amino acid
AM445_RS05930	COG0174	glutamine synthetase
AM445_RS05935	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AM445_RS05940	COG1396	sequence-specific DNA binding
AM445_RS05940	COG1917	Cupin 2, conserved barrel domain protein
AM445_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS05950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM445_RS05955	COG0583	DNA-binding transcription factor activity
AM445_RS05960	COG0473	3-isopropylmalate dehydrogenase activity
AM445_RS05965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM445_RS05970	COG4638	Rieske (2fe-2S)
AM445_RS05975	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS05980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM445_RS05985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS05985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS05985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM445_RS05990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS05995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS06000	COG1882	Formate acetyltransferase
AM445_RS06005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM445_RS06010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS06020	COG2207	Transcriptional regulator
AM445_RS06025	COG3706	GGDEF domain
AM445_RS06045	COG2200	EAL domain
AM445_RS06055	COG0058	SHG alpha-glucan phosphorylase activity
AM445_RS06070	COG0670	Belongs to the BI1 family
AM445_RS06085	COG2207	Transcriptional regulator
AM445_RS06090	COG1881	PFAM PEBP family protein
AM445_RS06115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS06120	COG2274	protein secretion by the type I secretion system
AM445_RS06145	COG1832	CoA-binding protein
AM445_RS06155	COG0210	DNA helicase
AM445_RS06160	COG3304	Inner membrane component domain
AM445_RS06165	COG1289	transmembrane transporter activity
AM445_RS06170	COG3070	regulator of competence-specific genes
AM445_RS06195	COG1067	ATP-dependent peptidase activity
AM445_RS06205	COG3130	regulation of translation
AM445_RS06215	COG3009	Protein conserved in bacteria
AM445_RS06220	COG3008	intermembrane lipid transfer
AM445_RS06220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM445_RS06225	COG2995	paraquat-inducible protein a
AM445_RS06230	COG0488	(ABC) transporter
AM445_RS06240	COG0633	Ferredoxin
AM445_RS06240	COG3217	Mosc domain protein beta barrel domain protein
AM445_RS06255	COG0431	NADPH-dependent FMN reductase
AM445_RS06260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM445_RS06265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM445_RS06270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM445_RS06280	COG0308	aminopeptidase N
AM445_RS06295	COG1473	amidohydrolase
AM445_RS06305	COG0814	amino acid
AM445_RS06315	COG1522	sequence-specific DNA binding
AM445_RS06330	COG1448	Aminotransferase
AM445_RS06335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM445_RS06340	COG3108	Peptidase M15
AM445_RS06350	COG2989	Protein conserved in bacteria
AM445_RS06360	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AM445_RS06370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM445_RS06375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AM445_RS06380	COG3173	Aminoglycoside phosphotransferase
AM445_RS06395	COG3214	Protein conserved in bacteria
AM445_RS06410	COG2333	competence protein COMEC
AM445_RS06410	COG0658	competence protein
AM445_RS06420	COG0539	negative regulation of cytoplasmic translation
AM445_RS06440	COG2323	membrane
AM445_RS06445	COG1944	ATP diphosphatase activity
AM445_RS06450	COG2116	formate transmembrane transporter activity
AM445_RS06455	COG1882	Formate acetyltransferase
AM445_RS06460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM445_RS06465	COG0477	Major facilitator Superfamily
AM445_RS06475	COG3302	dmso reductase anchor subunit
AM445_RS06480	COG0437	4 iron, 4 sulfur cluster binding
AM445_RS06485	COG0243	molybdopterin cofactor binding
AM445_RS06495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM445_RS06505	COG1674	ftsk spoiiie
AM445_RS06505	COG1178	ABC-type Fe3 transport system permease component
AM445_RS06515	COG0492	ferredoxin-NADP+ reductase activity
AM445_RS06520	COG4988	ABC transporter
AM445_RS06525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AM445_RS06540	COG0542	response to heat
AM445_RS06550	COG1278	Cold shock
AM445_RS06565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS06570	COG3593	DNA synthesis involved in DNA repair
AM445_RS06580	COG2431	L-lysine efflux transmembrane transporter activity
AM445_RS06590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM445_RS06605	COG0028	Belongs to the TPP enzyme family
AM445_RS06610	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AM445_RS06615	COG0702	epimerase
AM445_RS06620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM445_RS06625	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM445_RS06630	COG4251	negative regulation of phosphorylation
AM445_RS06630	COG2203	Gaf domain
AM445_RS06630	COG3706	GGDEF domain
AM445_RS06630	COG5001	Diguanylate cyclase
AM445_RS06645	COG1126	abc transporter atp-binding protein
AM445_RS06650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS06655	COG4215	(ABC) transporter
AM445_RS06660	COG4160	amino acid transport
AM445_RS06665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS06670	COG5002	protein histidine kinase activity
AM445_RS06675	COG0745	RESPONSE REGULATOR receiver
AM445_RS06690	COG1177	transmembrane transport
AM445_RS06695	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM445_RS06700	COG3842	ATPase activity
AM445_RS06705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM445_RS06720	COG0778	Nitroreductase
AM445_RS06745	COG3226	Transcriptional regulator
AM445_RS06750	COG0738	Major facilitator superfamily
AM445_RS06755	COG0561	phosphatase activity
AM445_RS06760	COG2814	Major facilitator Superfamily
AM445_RS06770	COG0671	phosphoesterase, PA-phosphatase related
AM445_RS06775	COG1349	DNA-binding transcription factor activity
AM445_RS06780	COG1686	Belongs to the peptidase S11 family
AM445_RS06785	COG0625	glutathione transferase activity
AM445_RS06790	COG2133	pyrroloquinoline quinone binding
AM445_RS06800	COG2223	nitrite transmembrane transporter activity
AM445_RS06825	COG0747	negative chemotaxis
AM445_RS06840	COG0303	'Molybdopterin
AM445_RS06845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM445_RS06850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM445_RS06855	COG1882	Formate acetyltransferase
AM445_RS06860	COG0561	phosphatase activity
AM445_RS06870	COG1609	Transcriptional regulator
AM445_RS06875	COG2271	Major facilitator Superfamily
AM445_RS06890	COG0488	(ABC) transporter
AM445_RS06895	COG2365	Tyrosine phosphatase family
AM445_RS06900	COG1376	ErfK ybiS ycfS ynhG family protein
AM445_RS06905	COG2188	Transcriptional regulator
AM445_RS06910	COG2723	6-phospho-beta-galactosidase activity
AM445_RS06915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM445_RS06930	COG2194	sulfuric ester hydrolase activity
AM445_RS06935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM445_RS06950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS06955	COG0765	amino acid transport
AM445_RS06960	COG1126	abc transporter atp-binding protein
AM445_RS06965	COG0668	transmembrane transport
AM445_RS06975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM445_RS06985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM445_RS06995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM445_RS07000	COG1199	ATP-dependent helicase activity
AM445_RS07005	COG0513	Belongs to the DEAD box helicase family
AM445_RS07010	COG3958	Transketolase
AM445_RS07015	COG3959	Transketolase, thiamine diphosphate binding domain
AM445_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS07025	COG2271	Major facilitator Superfamily
AM445_RS07030	COG0583	DNA-binding transcription factor activity
AM445_RS07035	COG1309	transcriptional regulator
AM445_RS07040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS07045	COG1131	(ABC) transporter
AM445_RS07050	COG0842	Transport permease protein
AM445_RS07055	COG0842	Transport permease protein
AM445_RS07070	COG3568	Endonuclease Exonuclease Phosphatase
AM445_RS07075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM445_RS07080	COG0392	lysyltransferase activity
AM445_RS07100	COG0670	Belongs to the BI1 family
AM445_RS07105	COG0314	molybdopterin synthase activity
AM445_RS07110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AM445_RS07120	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM445_RS07145	COG0745	RESPONSE REGULATOR receiver
AM445_RS07150	COG0642	Histidine kinase
AM445_RS07185	COG2226	methyltransferase
AM445_RS07205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AM445_RS07210	COG1881	PFAM PEBP family protein
AM445_RS07245	COG4677	pectinesterase activity
AM445_RS07255	COG0589	response to stress
AM445_RS07260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS07290	COG0789	Transcriptional regulator
AM445_RS07295	COG2200	EAL domain
AM445_RS07320	COG0561	phosphatase activity
AM445_RS07330	COG4149	molybdate abc transporter
AM445_RS07335	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM445_RS07345	COG3585	molybdate ion transport
AM445_RS07345	COG2005	Transcriptional regulator
AM445_RS07350	COG1119	ATPase activity
AM445_RS07360	COG1085	galactose-1-phosphate uridylyltransferase
AM445_RS07370	COG2017	converts alpha-aldose to the beta-anomer
AM445_RS07380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM445_RS07395	COG3201	nicotinamide mononucleotide transporter
AM445_RS07400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM445_RS07445	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AM445_RS07450	COG2885	chlorophyll binding
AM445_RS07460	COG3064	Membrane
AM445_RS07465	COG0848	biopolymer transport protein
AM445_RS07470	COG0811	peptide transport
AM445_RS07475	COG0824	Thioesterase
AM445_RS07480	COG3790	cyd operon protein YbgE
AM445_RS07485	COG4890	Cyd operon protein YbgT
AM445_RS07490	COG1294	oxidase, subunit
AM445_RS07495	COG1271	oxidase subunit
AM445_RS07505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AM445_RS07515	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM445_RS07520	COG0567	Dehydrogenase, E1 component
AM445_RS07525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM445_RS07530	COG1053	succinate dehydrogenase
AM445_RS07535	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM445_RS07540	COG2009	succinate dehydrogenase
AM445_RS07585	COG1984	allophanate hydrolase subunit 2
AM445_RS07590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AM445_RS07605	COG0415	Belongs to the DNA photolyase family
AM445_RS07635	COG2205	protein histidine kinase activity
AM445_RS07640	COG0745	RESPONSE REGULATOR receiver
AM445_RS07650	COG0033	Phosphoglucomutase
AM445_RS07660	COG0596	Alpha beta hydrolase
AM445_RS07675	COG0735	belongs to the Fur family
AM445_RS07720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AM445_RS07725	COG1846	Transcriptional regulator
AM445_RS07725	COG1940	carbohydrate kinase activity
AM445_RS07730	COG0647	UMP catabolic process
AM445_RS07735	COG0367	asparagine synthase
AM445_RS07780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM445_RS07790	COG1702	phosphate starvation-inducible protein PhoH
AM445_RS07815	COG0765	amino acid transport
AM445_RS07820	COG0765	amino acid transport
AM445_RS07825	COG1126	abc transporter atp-binding protein
AM445_RS07840	COG2888	peptidyl-tyrosine sulfation
AM445_RS07855	COG1466	dna polymerase III delta subunit
AM445_RS07875	COG0799	negative regulation of ribosome biogenesis
AM445_RS07885	COG0768	penicillin binding
AM445_RS07890	COG0772	Belongs to the SEDS family
AM445_RS07895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM445_RS07900	COG1686	Belongs to the peptidase S11 family
AM445_RS07915	COG0583	DNA-binding transcription factor activity
AM445_RS07925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM445_RS07930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM445_RS07950	COG3069	C4-dicarboxylate transmembrane transporter activity
AM445_RS07955	COG3719	Belongs to the RNase T2 family
AM445_RS07960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM445_RS07980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM445_RS07985	COG0583	DNA-binding transcription factor activity
AM445_RS07990	COG3969	phosphoadenosine phosphosulfate
AM445_RS07995	COG1475	DNA binding
AM445_RS08000	COG0436	Aminotransferase
AM445_RS08025	COG1129	ABC transporter
AM445_RS08030	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS08035	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS08045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM445_RS08060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM445_RS08070	COG0402	S-adenosylhomocysteine deaminase activity
AM445_RS08080	COG0483	inositol monophosphate 1-phosphatase activity
AM445_RS08085	COG2271	Major facilitator Superfamily
AM445_RS08115	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS08120	COG1129	ABC transporter
AM445_RS08125	COG0371	Dehydrogenase
AM445_RS08130	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS08145	COG2879	small protein
AM445_RS08150	COG1966	Carbon starvation protein
AM445_RS08160	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS08165	COG3433	isochorismatase activity
AM445_RS08165	COG1535	isochorismatase
AM445_RS08170	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM445_RS08175	COG1169	isochorismate synthase
AM445_RS08180	COG4592	Periplasmic binding protein
AM445_RS08190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS08195	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS08200	COG1120	ATPase activity
AM445_RS08205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM445_RS08205	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AM445_RS08210	COG3251	PFAM MbtH domain protein
AM445_RS08215	COG2382	esterase
AM445_RS08220	COG4771	TonB-dependent receptor
AM445_RS08230	COG1879	ABC-type sugar transport system periplasmic component
AM445_RS08240	COG1129	ABC transporter
AM445_RS08245	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS08250	COG5464	transposase or invertase
AM445_RS08255	COG2390	Transcriptional regulator
AM445_RS08260	COG3959	Transketolase, thiamine diphosphate binding domain
AM445_RS08265	COG3958	Transketolase
AM445_RS08275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM445_RS08285	COG0583	DNA-binding transcription factor activity
AM445_RS08290	COG0668	transmembrane transport
AM445_RS08300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM445_RS08330	COG0747	negative chemotaxis
AM445_RS08335	COG0601	transmembrane transport
AM445_RS08340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS08345	COG0444	Belongs to the ABC transporter superfamily
AM445_RS08350	COG4608	Belongs to the ABC transporter superfamily
AM445_RS08370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AM445_RS08375	COG4221	oxidoreductase activity
AM445_RS08385	COG4215	(ABC) transporter
AM445_RS08390	COG0765	amino acid transport
AM445_RS08395	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AM445_RS08410	COG0697	spore germination
AM445_RS08425	COG4608	Belongs to the ABC transporter superfamily
AM445_RS08430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS08440	COG4166	transmembrane transport
AM445_RS08450	COG3698	Phosphodiester glycosidase
AM445_RS08495	COG2315	Protein conserved in bacteria
AM445_RS08530	COG0477	Major facilitator Superfamily
AM445_RS08535	COG0668	transmembrane transport
AM445_RS08540	COG1609	Transcriptional regulator
AM445_RS08550	COG0673	inositol 2-dehydrogenase activity
AM445_RS08560	COG2211	Major facilitator Superfamily
AM445_RS08565	COG1113	amino acid transport
AM445_RS08580	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS08585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM445_RS08595	COG0531	amino acid
AM445_RS08610	COG4680	protein conserved in bacteria
AM445_RS08665	COG0667	Aldo Keto reductase
AM445_RS08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS08675	COG1473	amidohydrolase
AM445_RS08695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS08700	COG1120	ATPase activity
AM445_RS08705	COG1566	PFAM secretion protein HlyD family protein
AM445_RS08750	COG4211	Belongs to the binding-protein-dependent transport system permease family
AM445_RS08755	COG1129	ABC transporter
AM445_RS08770	COG0673	inositol 2-dehydrogenase activity
AM445_RS08805	COG3104	oligopeptide transport
AM445_RS08810	COG1982	Orn Lys Arg decarboxylase major
AM445_RS08815	COG0531	amino acid
AM445_RS08820	COG3710	Transcriptional regulator
AM445_RS08830	COG1560	Kdo2-lipid A biosynthetic process
AM445_RS08885	COG2501	S4 domain
AM445_RS08895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM445_RS08915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM445_RS08920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM445_RS08935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AM445_RS08940	COG4181	ATPase activity
AM445_RS08945	COG2755	lipolytic protein G-D-S-L family
AM445_RS08950	COG0300	oxidoreductase activity
AM445_RS08955	COG3118	belongs to the thioredoxin family
AM445_RS08965	COG0390	transport system, permease component
AM445_RS08970	COG4619	ABC transporter
AM445_RS08975	COG0330	HflC and HflK could
AM445_RS08980	COG1585	Membrane protein implicated in regulation of membrane protease activity
AM445_RS08995	COG3735	TraB family
AM445_RS09000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM445_RS09010	COG2223	nitrite transmembrane transporter activity
AM445_RS09015	COG4651	solute:proton antiporter activity
AM445_RS09015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM445_RS09020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM445_RS09065	COG2832	Protein of unknown function (DUF454)
AM445_RS09070	COG3923	Primosomal replication protein n
AM445_RS09080	COG5464	transposase or invertase
AM445_RS09085	COG1196	nuclear chromosome segregation
AM445_RS09085	COG3264	Mechanosensitive ion channel
AM445_RS09090	COG1309	transcriptional regulator
AM445_RS09095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS09100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM445_RS09115	COG0110	maltose O-acetyltransferase activity
AM445_RS09160	COG1874	Beta-galactosidase
AM445_RS09165	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AM445_RS09170	COG3833	ABC-type maltose transport systems, permease component
AM445_RS09175	COG1175	transmembrane transport
AM445_RS09180	COG2182	Extracellular solute-binding protein
AM445_RS09190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM445_RS09205	COG2364	Membrane
AM445_RS09235	COG3695	enzyme binding
AM445_RS09240	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AM445_RS09245	COG1946	Acyl-CoA thioesterase
AM445_RS09250	COG0004	ammonium transporteR
AM445_RS09255	COG0347	Belongs to the P(II) protein family
AM445_RS09260	COG1132	(ABC) transporter
AM445_RS09265	COG1132	(ABC) transporter
AM445_RS09270	COG1522	sequence-specific DNA binding
AM445_RS09285	COG4533	DNA binding
AM445_RS09295	COG0824	Thioesterase
AM445_RS09300	COG1555	photosystem II stabilization
AM445_RS09305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM445_RS09310	COG0776	regulation of translation
AM445_RS09315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AM445_RS09345	COG0271	Belongs to the BolA IbaG family
AM445_RS09350	COG3056	Lipoprotein
AM445_RS09355	COG2223	nitrite transmembrane transporter activity
AM445_RS09360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM445_RS09365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM445_RS09370	COG1845	cytochrome c oxidase, subunit III
AM445_RS09375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AM445_RS09390	COG1414	Transcriptional regulator
AM445_RS09395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM445_RS09400	COG1053	succinate dehydrogenase
AM445_RS09410	COG1053	succinate dehydrogenase
AM445_RS09425	COG0673	inositol 2-dehydrogenase activity
AM445_RS09430	COG2814	Major facilitator Superfamily
AM445_RS09440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AM445_RS09445	COG0693	protein deglycase activity
AM445_RS09465	COG0142	geranyltranstransferase activity
AM445_RS09475	COG0667	Aldo Keto reductase
AM445_RS09480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AM445_RS09500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM445_RS09500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM445_RS09510	COG4238	major outer membrane lipoprotein
AM445_RS09530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM445_RS09535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM445_RS09540	COG1862	Preprotein translocase
AM445_RS09560	COG0450	alkyl hydroperoxide reductase
AM445_RS09565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS09580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM445_RS09590	COG1228	amidohydrolase
AM445_RS09600	COG1335	isochorismatase
AM445_RS09605	COG0583	DNA-binding transcription factor activity
AM445_RS09610	COG0366	Alpha amylase catalytic
AM445_RS09635	COG0420	3'-5' exonuclease activity
AM445_RS09640	COG0419	ATPase involved in DNA repair
AM445_RS09645	COG1940	carbohydrate kinase activity
AM445_RS09660	COG4126	flavin adenine dinucleotide binding
AM445_RS09670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AM445_RS09675	COG3416	Protein conserved in bacteria
AM445_RS09685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AM445_RS09695	COG1785	Belongs to the alkaline phosphatase family
AM445_RS09735	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AM445_RS09740	COG1335	isochorismatase
AM445_RS09745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AM445_RS09750	COG0113	porphobilinogen synthase activity
AM445_RS09755	COG1943	Transposase
AM445_RS09765	COG2175	clavaminate synthase activity
AM445_RS09770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM445_RS09775	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AM445_RS09780	COG4521	taurine ABC transporter
AM445_RS09785	COG2040	homocysteine
AM445_RS09790	COG0833	amino acid
AM445_RS09800	COG4303	Ethanolamine ammonia lyase large subunit
AM445_RS09805	COG4302	ethanolamine ammonia-lyase activity
AM445_RS09845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS09850	COG1126	abc transporter atp-binding protein
AM445_RS09855	COG4597	amino acid ABC transporter
AM445_RS09860	COG0765	amino acid transport
AM445_RS09875	COG3188	usher protein
AM445_RS09900	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AM445_RS09910	COG3639	organic phosphonate transmembrane transporter activity
AM445_RS09935	COG0791	NLP P60 protein
AM445_RS09960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM445_RS09995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM445_RS10000	COG0022	dehydrogenase e1 component
AM445_RS10005	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM445_RS10010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM445_RS10035	COG1070	Carbohydrate kinase
AM445_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS10045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM445_RS10050	COG3775	system Galactitol-specific IIC component
AM445_RS10055	COG0625	glutathione transferase activity
AM445_RS10060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AM445_RS10080	COG0579	oxidoreductase
AM445_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS10090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM445_RS10095	COG1113	amino acid transport
AM445_RS10100	COG1802	Transcriptional regulator
AM445_RS10120	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM445_RS10125	COG0454	-acetyltransferase
AM445_RS10140	COG2991	Protein conserved in bacteria
AM445_RS10155	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM445_RS10160	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM445_RS10180	COG3034	peptidoglycan biosynthetic process
AM445_RS10185	COG0121	glutamine amidotransferase
AM445_RS10195	COG1960	acyl-CoA dehydrogenase activity
AM445_RS10200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM445_RS10210	COG0583	DNA-binding transcription factor activity
AM445_RS10225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM445_RS10235	COG2226	methyltransferase
AM445_RS10245	COG0741	lytic transglycosylase activity
AM445_RS10245	COG1388	LysM domain
AM445_RS10250	COG2226	methyltransferase
AM445_RS10265	COG0583	DNA-binding transcription factor activity
AM445_RS10270	COG0656	L-ascorbic acid biosynthetic process
AM445_RS10310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AM445_RS10320	COG2011	ABC-type metal ion transport system permease component
AM445_RS10325	COG1464	Belongs to the NlpA lipoprotein family
AM445_RS10335	COG1720	tRNA m6t6A37 methyltransferase activity
AM445_RS10345	COG0791	NLP P60 protein
AM445_RS10350	COG3015	lipoprotein NlpE involved in copper resistance
AM445_RS10355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AM445_RS10370	COG4568	rho-dependent transcription termination
AM445_RS10380	COG0346	lactoylglutathione lyase activity
AM445_RS10385	COG1982	Orn Lys Arg decarboxylase major
AM445_RS10395	COG0587	DNA-directed DNA polymerase activity
AM445_RS10425	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AM445_RS10435	COG0750	zinc metalloprotease
AM445_RS10440	COG0575	Belongs to the CDS family
AM445_RS10455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM445_RS10480	COG0024	Methionine aminopeptidase
AM445_RS10485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AM445_RS10500	COG3835	regulator
AM445_RS10505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM445_RS10525	COG2860	membrane
AM445_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS10550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM445_RS10555	COG1120	ATPase activity
AM445_RS10560	COG4774	siderophore transport
AM445_RS10565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM445_RS10655	COG1643	Atp-dependent helicase
AM445_RS10660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AM445_RS10680	COG0617	tRNA 3'-terminal CCA addition
AM445_RS10685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AM445_RS10705	COG0726	polysaccharide deacetylase
AM445_RS10710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS10715	COG0842	Transport permease protein
AM445_RS10720	COG1131	(ABC) transporter
AM445_RS10725	COG0288	reversible hydration of carbon dioxide
AM445_RS10735	COG4993	Dehydrogenase
AM445_RS10740	COG2132	Multicopper oxidase
AM445_RS10785	COG3064	Membrane
AM445_RS10800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM445_RS10805	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM445_RS10810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AM445_RS10815	COG2186	Transcriptional regulator
AM445_RS10820	COG1113	amino acid transport
AM445_RS10825	COG2211	Major facilitator Superfamily
AM445_RS10830	COG3940	Belongs to the glycosyl hydrolase 43 family
AM445_RS10835	COG3725	Membrane protein required for beta-lactamase induction
AM445_RS10840	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM445_RS10850	COG4969	Belongs to the N-Me-Phe pilin family
AM445_RS10855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM445_RS10860	COG1459	type II secretion system
AM445_RS10885	COG0494	nUDIX hydrolase
AM445_RS10905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM445_RS10910	COG0849	cell division
AM445_RS10935	COG0772	Belongs to the SEDS family
AM445_RS10950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM445_RS10955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM445_RS10960	COG0768	penicillin binding
AM445_RS10985	COG1609	Transcriptional regulator
AM445_RS10995	COG0028	Belongs to the TPP enzyme family
AM445_RS11045	COG0738	Major facilitator superfamily
AM445_RS11055	COG0583	DNA-binding transcription factor activity
AM445_RS11060	COG2271	Major facilitator Superfamily
AM445_RS11065	COG2814	Major facilitator Superfamily
AM445_RS11085	COG1178	ABC-type Fe3 transport system permease component
AM445_RS11095	COG0586	Pfam SNARE associated Golgi protein
AM445_RS11115	COG0235	Class ii aldolase
AM445_RS11120	COG0417	DNA replication proofreading
AM445_RS11130	COG0564	pseudouridine synthase activity
AM445_RS11145	COG3493	citrate carrier protein
AM445_RS11160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AM445_RS11165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AM445_RS11175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM445_RS11225	COG0505	Belongs to the CarA family
AM445_RS11240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AM445_RS11250	COG3152	Membrane
AM445_RS11265	COG1047	Peptidyl-prolyl cis-trans
AM445_RS11280	COG0196	riboflavin kinase activity
AM445_RS11295	COG0583	DNA-binding transcription factor activity
AM445_RS11320	COG4735	regulation of single-species biofilm formation
AM445_RS11325	COG1584	GPR1 FUN34 yaaH family protein
AM445_RS11330	COG0477	Major facilitator Superfamily
AM445_RS11335	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM445_RS11340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM445_RS11345	COG1115	amino acid carrier protein
AM445_RS11360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM445_RS11370	COG0527	aspartate kinase activity
AM445_RS11370	COG0460	homoserine dehydrogenase
AM445_RS11380	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AM445_RS11395	COG0745	RESPONSE REGULATOR receiver
AM445_RS11400	COG4452	Inner membrane protein CreD
AM445_RS11405	COG2205	protein histidine kinase activity
AM445_RS11410	COG0745	RESPONSE REGULATOR receiver
AM445_RS11415	COG3045	CreA protein
AM445_RS11420	COG2207	Transcriptional regulator
AM445_RS11420	COG3708	Transcriptional regulator
AM445_RS11440	COG0741	lytic transglycosylase activity
AM445_RS11450	COG0488	(ABC) transporter
AM445_RS11460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AM445_RS11465	COG0560	Phosphoserine phosphatase
AM445_RS11475	COG3726	membrane protein affecting hemolysin expression
AM445_RS11505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM445_RS11510	COG0084	hydrolase, TatD family'
AM445_RS11515	COG4667	esterase of the alpha-beta hydrolase superfamily
AM445_RS11520	COG5487	UPF0391 membrane protein
AM445_RS11525	COG2823	Periplasmic or secreted lipoprotein
AM445_RS11535	COG1011	Hydrolase
AM445_RS11540	COG0456	acetyltransferase
AM445_RS11545	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AM445_RS11575	COG3706	GGDEF domain
AM445_RS11580	COG4114	ferric iron reductase
AM445_RS11585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS11585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS11590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM445_RS11595	COG2197	response regulator
AM445_RS11600	COG2197	response regulator
AM445_RS11615	COG2966	Psort location CytoplasmicMembrane, score
AM445_RS11630	COG1484	DNA-dependent DNA replication
AM445_RS11645	COG5464	transposase or invertase
AM445_RS11655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM445_RS11660	COG3716	PTS system mannose fructose sorbose family IID component
AM445_RS11665	COG3715	PTS system
AM445_RS11680	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AM445_RS11680	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AM445_RS11685	COG1214	PFAM Peptidase M22, glycoprotease
AM445_RS11685	COG0456	acetyltransferase
AM445_RS11695	COG1737	Transcriptional regulator
AM445_RS11700	COG0800	Aldolase
AM445_RS11705	COG3734	2-keto-3-deoxy-galactonokinase
AM445_RS11720	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AM445_RS11750	COG1846	Transcriptional regulator
AM445_RS11755	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM445_RS11765	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS11770	COG3384	dioxygenase
AM445_RS11780	COG3971	2-oxopent-4-enoate hydratase activity
AM445_RS11800	COG2368	4-hydroxyphenylacetate
AM445_RS11805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM445_RS11820	COG1966	Carbon starvation protein
AM445_RS11825	COG2879	small protein
AM445_RS11830	COG0523	cobalamin synthesis protein
AM445_RS11840	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS11845	COG5464	transposase or invertase
AM445_RS11850	COG1917	Cupin 2, conserved barrel domain protein
AM445_RS11850	COG2207	Transcriptional regulator
AM445_RS11860	COG2733	membrane
AM445_RS11875	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AM445_RS11880	COG1924	4 iron, 4 sulfur cluster binding
AM445_RS11895	COG1566	PFAM secretion protein HlyD family protein
AM445_RS11905	COG5457	Domain of unknown function (DUF1127)
AM445_RS11910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM445_RS11920	COG0583	DNA-binding transcription factor activity
AM445_RS11925	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM445_RS11935	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS11940	COG1129	ABC transporter
AM445_RS11945	COG1879	ABC-type sugar transport system periplasmic component
AM445_RS11955	COG3706	GGDEF domain
AM445_RS11960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS11965	COG1129	ABC transporter
AM445_RS11965	COG0842	Transport permease protein
AM445_RS11970	COG0842	Transport permease protein
AM445_RS12005	COG2850	peptidyl-arginine hydroxylation
AM445_RS12020	COG5002	protein histidine kinase activity
AM445_RS12025	COG0745	RESPONSE REGULATOR receiver
AM445_RS12035	COG1538	Outer membrane efflux protein
AM445_RS12040	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS12045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS12050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM445_RS12060	COG3040	lipid binding
AM445_RS12065	COG0789	Transcriptional regulator
AM445_RS12070	COG3631	Ketosteroid isomerase-related protein
AM445_RS12075	COG0300	oxidoreductase activity
AM445_RS12090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM445_RS12110	COG3272	Protein of unknown function (DUF1722)
AM445_RS12115	COG4580	involved in the transport of maltose and maltodextrins
AM445_RS12120	COG2115	Belongs to the xylose isomerase family
AM445_RS12125	COG2211	Major facilitator Superfamily
AM445_RS12130	COG3507	Belongs to the glycosyl hydrolase 43 family
AM445_RS12150	COG1216	Glycosyl transferase, family 2
AM445_RS12210	COG1715	Restriction endonuclease
AM445_RS12215	COG1196	nuclear chromosome segregation
AM445_RS12235	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AM445_RS12240	COG0582	viral genome integration into host DNA
AM445_RS12255	COG0288	reversible hydration of carbon dioxide
AM445_RS12260	COG0659	secondary active sulfate transmembrane transporter activity
AM445_RS12265	COG1064	alcohol dehydrogenase
AM445_RS12270	COG1175	transmembrane transport
AM445_RS12275	COG0395	ABC-type sugar transport system, permease component
AM445_RS12280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM445_RS12285	COG3842	ATPase activity
AM445_RS12300	COG1082	Xylose isomerase domain protein TIM barrel
AM445_RS12310	COG3962	Belongs to the TPP enzyme family
AM445_RS12315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM445_RS12320	COG0837	glucose binding
AM445_RS12320	COG1737	Transcriptional regulator
AM445_RS12345	COG3718	enzyme involved in inositol metabolism
AM445_RS12360	COG0433	COG0433 Predicted ATPase
AM445_RS12365	COG0795	lipopolysaccharide-transporting ATPase activity
AM445_RS12370	COG0795	lipopolysaccharide-transporting ATPase activity
AM445_RS12385	COG2927	DNA polymerase III (CHI subunit)
AM445_RS12390	COG0525	valine-tRNA ligase activity
AM445_RS12415	COG2731	YhcH YjgK YiaL family protein
AM445_RS12455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM445_RS12455	COG1263	PTS System
AM445_RS12460	COG0366	Alpha amylase catalytic
AM445_RS12465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS12470	COG1486	melibiose metabolic process
AM445_RS12490	COG0602	queuosine metabolic process
AM445_RS12495	COG2026	Addiction module toxin, RelE StbE family
AM445_RS12500	COG3077	Addiction module antitoxin, RelB DinJ family
AM445_RS12505	COG3711	transcriptional antiterminator
AM445_RS12505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS12510	COG2706	6-phosphogluconolactonase activity
AM445_RS12525	COG3964	amidohydrolase
AM445_RS12560	COG0312	modulator of DNA gyrase
AM445_RS12580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM445_RS12590	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS12595	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS12600	COG1129	ABC transporter
AM445_RS12605	COG1879	ABC-type sugar transport system periplasmic component
AM445_RS12620	COG2105	PFAM AIG2 family protein
AM445_RS12625	COG2911	Protein conserved in bacteria
AM445_RS12630	COG0729	surface antigen
AM445_RS12640	COG1253	flavin adenine dinucleotide binding
AM445_RS12665	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AM445_RS12680	COG1733	regulation of RNA biosynthetic process
AM445_RS12685	COG0702	epimerase
AM445_RS12695	COG0697	spore germination
AM445_RS12705	COG1113	amino acid transport
AM445_RS12710	COG0545	Peptidyl-prolyl cis-trans isomerase
AM445_RS12715	COG3061	Opacity-associated protein A
AM445_RS12725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AM445_RS12730	COG2965	DNA replication, synthesis of RNA primer
AM445_RS12790	COG1073	alpha beta
AM445_RS12795	COG3650	response to hydrogen peroxide
AM445_RS12805	COG1960	acyl-CoA dehydrogenase activity
AM445_RS12810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM445_RS12815	COG0557	exoribonuclease II activity
AM445_RS12830	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AM445_RS12840	COG0330	HflC and HflK could
AM445_RS12845	COG0330	HflC and HflK could
AM445_RS12850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AM445_RS12870	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM445_RS12875	COG0802	atpase or kinase
AM445_RS12880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM445_RS12880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM445_RS12885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM445_RS12910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS12935	COG3264	Mechanosensitive ion channel
AM445_RS12935	COG1511	domain protein
AM445_RS12950	COG1053	succinate dehydrogenase
AM445_RS12955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM445_RS12975	COG2076	Multidrug Resistance protein
AM445_RS12980	COG5510	response to toxic substance
AM445_RS12995	COG1509	lysine 2,3-aminomutase activity
AM445_RS13060	COG0531	amino acid
AM445_RS13065	COG3030	protein affecting phage T7 exclusion by the F plasmid
AM445_RS13075	COG1027	Aspartate ammonia-lyase
AM445_RS13080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AM445_RS13095	COG1309	transcriptional regulator
AM445_RS13125	COG0457	Tetratricopeptide repeat
AM445_RS13130	COG1649	PFAM Uncharacterised BCR, COG1649
AM445_RS13130	COG0726	polysaccharide deacetylase
AM445_RS13135	COG1215	transferase activity, transferring glycosyl groups
AM445_RS13155	COG0861	Integral membrane protein TerC family
AM445_RS13185	COG1486	melibiose metabolic process
AM445_RS13195	COG2169	Transcriptional regulator
AM445_RS13210	COG2824	Alkylphosphonate utilization operon protein PhnA
AM445_RS13215	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AM445_RS13220	COG2188	Transcriptional regulator
AM445_RS13225	COG3624	Phosphonate C-P lyase system protein PhnG
AM445_RS13230	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AM445_RS13235	COG3626	phosphonate metabolism
AM445_RS13240	COG3627	carbon phosphorus lyase activity
AM445_RS13245	COG4107	phosphonate C-P lyase system protein PhnK
AM445_RS13250	COG4778	phosphonate C-P lyase system protein PhnL
AM445_RS13255	COG3454	Phosphonate metabolism
AM445_RS13265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AM445_RS13275	COG0784	Response regulator, receiver
AM445_RS13275	COG4191	Histidine kinase
AM445_RS13280	COG1129	ABC transporter
AM445_RS13285	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS13320	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AM445_RS13325	COG1301	dicarboxylic acid transport
AM445_RS13335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM445_RS13345	COG3162	membrane
AM445_RS13375	COG3539	Fimbrial protein
AM445_RS13380	COG1346	cytolysis
AM445_RS13385	COG1380	Effector of murein hydrolase LrgA
AM445_RS13390	COG0583	DNA-binding transcription factor activity
AM445_RS13395	COG0025	NhaP-type Na H and K H
AM445_RS13400	COG2252	PERMEase
AM445_RS13405	COG0625	glutathione transferase activity
AM445_RS13410	COG0789	Transcriptional regulator
AM445_RS13420	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM445_RS13455	COG1234	tRNA 3'-trailer cleavage
AM445_RS13460	COG1609	Transcriptional regulator
AM445_RS13465	COG0483	inositol monophosphate 1-phosphatase activity
AM445_RS13480	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM445_RS13500	COG4771	TonB-dependent receptor
AM445_RS13505	COG0741	lytic transglycosylase activity
AM445_RS13525	COG2315	Protein conserved in bacteria
AM445_RS13530	COG0432	Pfam Uncharacterised protein family UPF0047
AM445_RS13545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM445_RS13550	COG0305	Participates in initiation and elongation during chromosome replication
AM445_RS13565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM445_RS13575	COG0735	belongs to the Fur family
AM445_RS13580	COG3237	CsbD-like
AM445_RS13585	COG0534	Mate efflux family protein
AM445_RS13595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AM445_RS13670	COG0251	oxidation-reduction process
AM445_RS13680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM445_RS13700	COG0527	aspartate kinase activity
AM445_RS13750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM445_RS13760	COG0456	acetyltransferase
AM445_RS13805	COG0151	Belongs to the GarS family
AM445_RS13815	COG4191	Histidine kinase
AM445_RS13820	COG3678	ATP-independent chaperone mediated protein folding
AM445_RS13855	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AM445_RS13870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM445_RS13875	COG2104	thiamine diphosphate biosynthetic process
AM445_RS13895	COG3706	GGDEF domain
AM445_RS13905	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM445_RS13910	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AM445_RS13950	COG0250	Participates in transcription elongation, termination and antitermination
AM445_RS14000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM445_RS14035	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AM445_RS14045	COG1739	Uncharacterized protein family UPF0029
AM445_RS14090	COG0805	protein transport
AM445_RS14110	COG3165	ubiquinone biosynthetic process from chorismate
AM445_RS14140	COG0583	DNA-binding transcription factor activity
AM445_RS14145	COG0697	spore germination
AM445_RS14150	COG0561	phosphatase activity
AM445_RS14155	COG2267	carboxylic ester hydrolase activity
AM445_RS14160	COG1280	lysine exporter protein (LysE YggA)
AM445_RS14170	COG1280	lysine exporter protein (LysE YggA)
AM445_RS14205	COG0210	DNA helicase
AM445_RS14210	COG1011	Hydrolase
AM445_RS14240	COG3072	Adenylate cyclase
AM445_RS14255	COG2959	enzyme of heme biosynthesis
AM445_RS14260	COG3071	HemY protein
AM445_RS14305	COG2244	polysaccharide biosynthetic process
AM445_RS14310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM445_RS14315	COG0456	acetyltransferase
AM445_RS14320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AM445_RS14325	COG1088	dTDP-glucose 4,6-dehydratase activity
AM445_RS14330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM445_RS14335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AM445_RS14345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM445_RS14350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AM445_RS14360	COG3118	belongs to the thioredoxin family
AM445_RS14390	COG1811	Na channel or pump
AM445_RS14400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM445_RS14405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM445_RS14415	COG0583	DNA-binding transcription factor activity
AM445_RS14420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM445_RS14435	COG3978	acetolactate synthase activity
AM445_RS14455	COG3085	chromosome segregation
AM445_RS14530	COG0583	DNA-binding transcription factor activity
AM445_RS14555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AM445_RS14570	COG3443	Belongs to the bacterial solute-binding protein 9 family
AM445_RS14575	COG2207	Transcriptional regulator
AM445_RS14585	COG0371	Dehydrogenase
AM445_RS14590	COG0697	spore germination
AM445_RS14600	COG0583	DNA-binding transcription factor activity
AM445_RS14610	COG0737	Belongs to the 5'-nucleotidase family
AM445_RS14620	COG0460	homoserine dehydrogenase
AM445_RS14620	COG0527	aspartate kinase activity
AM445_RS14625	COG0626	cystathionine gamma-synthase activity
AM445_RS14640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM445_RS14645	COG1609	Transcriptional regulator
AM445_RS14650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM445_RS14665	COG1575	Belongs to the MenA family. Type 1 subfamily
AM445_RS14685	COG3678	ATP-independent chaperone mediated protein folding
AM445_RS14690	COG0745	RESPONSE REGULATOR receiver
AM445_RS14695	COG2205	protein histidine kinase activity
AM445_RS14700	COG2258	MOSC domain
AM445_RS14705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM445_RS14750	COG1129	ABC transporter
AM445_RS14755	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS14760	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS14765	COG1454	alcohol dehydrogenase
AM445_RS14775	COG2211	Major facilitator Superfamily
AM445_RS14820	COG3383	formate dehydrogenase (NAD+) activity
AM445_RS14820	COG0243	molybdopterin cofactor binding
AM445_RS14825	COG0243	molybdopterin cofactor binding
AM445_RS14825	COG3383	formate dehydrogenase (NAD+) activity
AM445_RS14830	COG0437	4 iron, 4 sulfur cluster binding
AM445_RS14835	COG2864	formate dehydrogenase
AM445_RS14850	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM445_RS14860	COG0456	acetyltransferase
AM445_RS14875	COG1011	Hydrolase
AM445_RS14895	COG3852	Histidine kinase
AM445_RS14905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM445_RS14935	COG0204	Acyl-transferase
AM445_RS14945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM445_RS14950	COG3084	Protein conserved in bacteria
AM445_RS14960	COG1763	Mo-molybdopterin cofactor biosynthetic process
AM445_RS14990	COG2186	Transcriptional regulator
AM445_RS14995	COG0477	Major facilitator Superfamily
AM445_RS15000	COG1609	Transcriptional regulator
AM445_RS15005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM445_RS15015	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS15020	COG1129	ABC transporter
AM445_RS15050	COG1522	sequence-specific DNA binding
AM445_RS15055	COG0716	FMN binding
AM445_RS15070	COG3312	ion transport
AM445_RS15120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM445_RS15215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM445_RS15220	COG0573	inorganic phosphate transmembrane transporter activity
AM445_RS15225	COG0581	inorganic phosphate transmembrane transporter activity
AM445_RS15230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM445_RS15235	COG0704	Plays a role in the regulation of phosphate uptake
AM445_RS15250	COG2382	esterase
AM445_RS15255	COG0363	glucosamine-6-phosphate deaminase activity
AM445_RS15260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM445_RS15270	COG2252	PERMEase
AM445_RS15275	COG0431	NADPH-dependent FMN reductase
AM445_RS15280	COG2091	lysine biosynthetic process via aminoadipic acid
AM445_RS15315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM445_RS15350	COG0187	DNA topoisomerase II activity
AM445_RS15355	COG0561	phosphatase activity
AM445_RS15370	COG2186	Transcriptional regulator
AM445_RS15375	COG3734	2-keto-3-deoxy-galactonokinase
AM445_RS15380	COG0800	Aldolase
AM445_RS15390	COG2271	Major facilitator Superfamily
AM445_RS15395	COG0823	Involved in the tonB-independent uptake of proteins
AM445_RS15400	COG5645	(Lipo)protein
AM445_RS15415	COG3645	SOS response
AM445_RS15425	COG2188	Transcriptional regulator
AM445_RS15440	COG2149	membrane
AM445_RS15460	COG2610	gluconate transmembrane transporter activity
AM445_RS15465	COG0583	DNA-binding transcription factor activity
AM445_RS15470	COG2814	Major facilitator Superfamily
AM445_RS15495	COG0028	Belongs to the TPP enzyme family
AM445_RS15500	COG0440	acetolactate synthase activity
AM445_RS15505	COG2197	response regulator
AM445_RS15515	COG2271	Major facilitator Superfamily
AM445_RS15560	COG2188	Transcriptional regulator
AM445_RS15585	COG4580	involved in the transport of maltose and maltodextrins
AM445_RS15590	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM445_RS15595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS15595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS15605	COG1609	Transcriptional regulator
AM445_RS15620	COG0583	DNA-binding transcription factor activity
AM445_RS15625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AM445_RS15630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM445_RS15635	COG2828	Protein conserved in bacteria
AM445_RS15650	COG0697	spore germination
AM445_RS15655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM445_RS15655	COG1263	PTS System
AM445_RS15665	COG2814	Major facilitator Superfamily
AM445_RS15675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM445_RS15710	COG0583	DNA-binding transcription factor activity
AM445_RS15735	COG1464	Belongs to the NlpA lipoprotein family
AM445_RS15750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AM445_RS15760	COG1064	alcohol dehydrogenase
AM445_RS15790	COG2211	Major facilitator Superfamily
AM445_RS15795	COG1501	Belongs to the glycosyl hydrolase 31 family
AM445_RS15805	COG1486	melibiose metabolic process
AM445_RS15810	COG1263	PTS System
AM445_RS15810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM445_RS15815	COG2982	Protein involved in outer membrane biogenesis
AM445_RS15820	COG2233	PERMEase
AM445_RS15825	COG0786	glutamate:sodium symporter activity
AM445_RS15845	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM445_RS15870	COG3152	Membrane
AM445_RS15880	COG1494	fructose-1,6-bisphosphatase
AM445_RS15885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM445_RS15890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM445_RS15895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM445_RS15915	COG2860	membrane
AM445_RS15925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM445_RS15925	COG2169	Transcriptional regulator
AM445_RS15930	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AM445_RS15935	COG1561	YicC-like family, N-terminal region
AM445_RS15955	COG1131	(ABC) transporter
AM445_RS15960	COG0842	Transport permease protein
AM445_RS15990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM445_RS16025	COG1519	Transferase
AM445_RS16030	COG1216	Glycosyl transferase, family 2
AM445_RS16035	COG0438	transferase activity, transferring glycosyl groups
AM445_RS16045	COG0859	PFAM glycosyl transferase family 9
AM445_RS16070	COG0859	PFAM glycosyl transferase family 9
AM445_RS16085	COG0156	8-amino-7-oxononanoate synthase activity
AM445_RS16095	COG0463	Glycosyl transferase, family 2
AM445_RS16100	COG2861	carbohydrate metabolic process
AM445_RS16105	COG4942	peptidase
AM445_RS16115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AM445_RS16120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM445_RS16140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM445_RS16150	COG2186	Transcriptional regulator
AM445_RS16170	COG3722	fumarate hydratase activity
AM445_RS16190	COG0625	glutathione transferase activity
AM445_RS16200	COG3276	selenocysteine insertion sequence binding
AM445_RS16205	COG1414	Transcriptional regulator
AM445_RS16210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM445_RS16215	COG3977	Valine--pyruvate aminotransferase
AM445_RS16220	COG0366	Alpha amylase catalytic
AM445_RS16230	COG2992	FlgJ-related protein
AM445_RS16235	COG1609	Transcriptional regulator
AM445_RS16235	COG2207	Transcriptional regulator
AM445_RS16240	COG4214	carbohydrate transport
AM445_RS16250	COG4213	ABC transporter substrate-binding protein
AM445_RS16270	COG4682	membrane
AM445_RS16275	COG4682	membrane
AM445_RS16280	COG3274	enterobacterial common antigen metabolic process
AM445_RS16320	COG1278	Cold shock
AM445_RS16325	COG2944	sequence-specific DNA binding
AM445_RS16330	COG2814	Major facilitator Superfamily
AM445_RS16355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM445_RS16365	COG1609	Transcriptional regulator
AM445_RS16370	COG2885	chlorophyll binding
AM445_RS16375	COG0243	molybdopterin cofactor binding
AM445_RS16380	COG0456	acetyltransferase
AM445_RS16385	COG2818	Glycosylase
AM445_RS16390	COG5571	outer membrane autotransporter
AM445_RS16395	COG2223	nitrite transmembrane transporter activity
AM445_RS16425	COG0747	negative chemotaxis
AM445_RS16430	COG0601	transmembrane transport
AM445_RS16435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS16440	COG0444	Belongs to the ABC transporter superfamily
AM445_RS16445	COG4608	Belongs to the ABC transporter superfamily
AM445_RS16460	COG2894	cell division
AM445_RS16470	COG1215	transferase activity, transferring glycosyl groups
AM445_RS16475	COG0457	Tetratricopeptide repeat
AM445_RS16490	COG2194	sulfuric ester hydrolase activity
AM445_RS16520	COG1215	transferase activity, transferring glycosyl groups
AM445_RS16525	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AM445_RS16530	COG0457	Tetratricopeptide repeat
AM445_RS16530	COG3118	belongs to the thioredoxin family
AM445_RS16535	COG2199	diguanylate cyclase activity
AM445_RS16535	COG2200	EAL domain
AM445_RS16550	COG0612	Peptidase, M16
AM445_RS16565	COG2982	Protein involved in outer membrane biogenesis
AM445_RS16570	COG0477	Major facilitator Superfamily
AM445_RS16580	COG1295	ribonuclease BN
AM445_RS16585	COG0583	DNA-binding transcription factor activity
AM445_RS16590	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS16595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM445_RS16605	COG1454	alcohol dehydrogenase
AM445_RS16615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM445_RS16620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AM445_RS16625	COG0671	phosphoesterase, PA-phosphatase related
AM445_RS16645	COG0589	response to stress
AM445_RS16655	COG0306	phosphate transporter
AM445_RS16660	COG2081	HI0933 family
AM445_RS16690	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AM445_RS16695	COG1196	nuclear chromosome segregation
AM445_RS16725	COG2239	Acts as a magnesium transporter
AM445_RS16740	COG1124	(ABC) transporter
AM445_RS16750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS16755	COG0601	transmembrane transport
AM445_RS16760	COG0747	negative chemotaxis
AM445_RS16775	COG3479	Phenolic acid decarboxylase
AM445_RS16815	COG0628	permease
AM445_RS16820	COG0477	Major facilitator Superfamily
AM445_RS16830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AM445_RS16845	COG3714	YhhN family
AM445_RS16855	COG3776	membrane
AM445_RS16860	COG0742	ribosomal rna small subunit methyltransferase
AM445_RS16865	COG0552	protein localization to endoplasmic reticulum
AM445_RS16870	COG2884	Cell division ATP-binding protein ftsE
AM445_RS16875	COG2177	Part of the ABC transporter FtsEX involved in
AM445_RS16890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM445_RS16900	COG0683	leucine binding
AM445_RS16915	COG0683	leucine binding
AM445_RS16920	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM445_RS16970	COG0584	glycerophosphoryl diester phosphodiesterase
AM445_RS16980	COG0405	Gamma-glutamyltransferase
AM445_RS16985	COG1247	-acetyltransferase
AM445_RS16995	COG0673	inositol 2-dehydrogenase activity
AM445_RS17000	COG1741	Belongs to the pirin family
AM445_RS17005	COG1609	Transcriptional regulator
AM445_RS17010	COG3265	gluconokinase activity
AM445_RS17015	COG2610	gluconate transmembrane transporter activity
AM445_RS17025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM445_RS17050	COG0058	SHG alpha-glucan phosphorylase activity
AM445_RS17055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM445_RS17070	COG1349	DNA-binding transcription factor activity
AM445_RS17085	COG0058	SHG alpha-glucan phosphorylase activity
AM445_RS17090	COG1640	4-alpha-glucanotransferase
AM445_RS17095	COG2610	gluconate transmembrane transporter activity
AM445_RS17105	COG1040	competence protein
AM445_RS17130	COG1918	ferrous iron import across plasma membrane
AM445_RS17135	COG2183	response to ionizing radiation
AM445_RS17140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM445_RS17165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AM445_RS17170	COG1011	Hydrolase
AM445_RS17180	COG0494	nUDIX hydrolase
AM445_RS17185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AM445_RS17210	COG4796	Type ii and iii secretion system protein
AM445_RS17230	COG3266	domain, Protein
AM445_RS17235	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AM445_RS17240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM445_RS17265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM445_RS17270	COG0402	S-adenosylhomocysteine deaminase activity
AM445_RS17275	COG0738	Major facilitator superfamily
AM445_RS17300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM445_RS17305	COG1289	transmembrane transporter activity
AM445_RS17320	COG1765	OsmC-like protein
AM445_RS17325	COG3954	Phosphoribulokinase
AM445_RS17335	COG0429	hydrolase of the alpha beta-hydrolase fold
AM445_RS17345	COG0488	(ABC) transporter
AM445_RS17365	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AM445_RS17370	COG1047	Peptidyl-prolyl cis-trans
AM445_RS17380	COG0545	Peptidyl-prolyl cis-trans isomerase
AM445_RS17385	COG2964	Protein conserved in bacteria
AM445_RS17445	COG0051	transcription antitermination factor activity, RNA binding
AM445_RS17470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AM445_RS17485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AM445_RS17550	COG0201	protein transport
AM445_RS17575	COG0202	RNA polymerase activity
AM445_RS17590	COG0789	Transcriptional regulator
AM445_RS17595	COG3036	rescue of stalled ribosome
AM445_RS17625	COG0758	DNA mediated transformation
AM445_RS17635	COG0551	DNA topoisomerase type I activity
AM445_RS17655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM445_RS17695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM445_RS17700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS17705	COG1309	transcriptional regulator
AM445_RS17730	COG4145	pantothenate transmembrane transporter activity
AM445_RS17735	COG3924	membrane
AM445_RS17740	COG0439	Biotin carboxylase
AM445_RS17745	COG0511	ligase activity, forming carbon-carbon bonds
AM445_RS17775	COG2199	diguanylate cyclase activity
AM445_RS17775	COG2200	EAL domain
AM445_RS17785	COG1077	Cell shape determining protein MreB Mrl
AM445_RS17790	COG1792	Involved in formation and maintenance of cell shape
AM445_RS17795	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AM445_RS17805	COG1530	ribonuclease E activity
AM445_RS17810	COG3164	Protein of unknown function
AM445_RS17815	COG0312	modulator of DNA gyrase
AM445_RS17820	COG0583	DNA-binding transcription factor activity
AM445_RS17835	COG1289	transmembrane transporter activity
AM445_RS17840	COG2732	(Barnase) inhibitor
AM445_RS17875	COG0471	metal ion transport
AM445_RS17880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM445_RS17885	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM445_RS17910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM445_RS17915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM445_RS17920	COG3105	Protein conserved in bacteria
AM445_RS17925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM445_RS17945	COG0625	glutathione transferase activity
AM445_RS17950	COG2969	positive regulation of protein catabolic process
AM445_RS17960	COG0493	'glutamate synthase
AM445_RS17965	COG0067	glutamate synthase
AM445_RS17965	COG0069	glutamate synthase activity
AM445_RS17965	COG0070	glutamate synthase
AM445_RS17975	COG1242	4 iron, 4 sulfur cluster binding
AM445_RS17980	COG2271	Major facilitator Superfamily
AM445_RS17985	COG1063	alcohol dehydrogenase
AM445_RS17990	COG1312	Catalyzes the dehydration of D-mannonate
AM445_RS17995	COG5002	protein histidine kinase activity
AM445_RS17995	COG0784	Response regulator, receiver
AM445_RS17995	COG2198	Histidine kinase
AM445_RS18000	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AM445_RS18005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM445_RS18010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS18020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS18025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM445_RS18030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AM445_RS18035	COG1137	ATPase activity
AM445_RS18040	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AM445_RS18045	COG3117	lipopolysaccharide transmembrane transporter activity
AM445_RS18050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AM445_RS18060	COG0530	calcium, potassium:sodium antiporter activity
AM445_RS18070	COG1127	ABC transporter
AM445_RS18075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM445_RS18080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM445_RS18085	COG2854	intermembrane phospholipid transfer
AM445_RS18090	COG3113	response to antibiotic
AM445_RS18095	COG5007	Belongs to the BolA IbaG family
AM445_RS18105	COG3423	Transcriptional regulator
AM445_RS18110	COG0142	geranyltranstransferase activity
AM445_RS18125	COG0697	spore germination
AM445_RS18135	COG2027	D-alanyl-D-alanine carboxypeptidase
AM445_RS18145	COG1534	Rna-binding protein
AM445_RS18155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM445_RS18160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM445_RS18170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AM445_RS18210	COG0195	Participates in both transcription termination and antitermination
AM445_RS18260	COG0814	amino acid
AM445_RS18265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM445_RS18270	COG0826	peptidase U32
AM445_RS18275	COG0826	peptidase U32
AM445_RS18280	COG3154	lipid carrier protein
AM445_RS18285	COG3153	acetyltransferase
AM445_RS18300	COG0693	protein deglycase activity
AM445_RS18305	COG0702	epimerase
AM445_RS18310	COG0701	Predicted permease
AM445_RS18315	COG2823	Periplasmic or secreted lipoprotein
AM445_RS18335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AM445_RS18340	COG2721	sulfolactate sulfo-lyase activity
AM445_RS18345	COG2271	Major facilitator Superfamily
AM445_RS18355	COG2084	Dehydrogenase
AM445_RS18360	COG1929	Belongs to the glycerate kinase type-1 family
AM445_RS18380	COG1741	Belongs to the pirin family
AM445_RS18385	COG0583	DNA-binding transcription factor activity
AM445_RS18390	COG3152	Membrane
AM445_RS18395	COG0435	Glutathione S-transferase
AM445_RS18400	COG2259	Doxx family
AM445_RS18410	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AM445_RS18415	COG4575	ribosome binding
AM445_RS18420	COG1422	Protein of unknown function (DUF1090)
AM445_RS18430	COG0586	Pfam SNARE associated Golgi protein
AM445_RS18440	COG2186	Transcriptional regulator
AM445_RS18445	COG2271	Major facilitator Superfamily
AM445_RS18455	COG2721	sulfolactate sulfo-lyase activity
AM445_RS18470	COG0861	Integral membrane protein TerC family
AM445_RS18475	COG0673	inositol 2-dehydrogenase activity
AM445_RS18480	COG1451	nucleotide metabolic process
AM445_RS18500	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM445_RS18500	COG1902	pentaerythritol trinitrate reductase activity
AM445_RS18555	COG1695	Transcriptional regulator
AM445_RS18560	COG2375	cellular response to nickel ion
AM445_RS18575	COG1461	Dihydroxyacetone kinase
AM445_RS18580	COG2376	Dihydroxyacetone kinase
AM445_RS18650	COG3247	response to pH
AM445_RS18660	COG2198	Histidine kinase
AM445_RS18660	COG2205	protein histidine kinase activity
AM445_RS18660	COG0784	Response regulator, receiver
AM445_RS18660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS18665	COG2197	response regulator
AM445_RS18680	COG0582	viral genome integration into host DNA
AM445_RS18715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM445_RS18770	COG4695	Portal protein
AM445_RS18930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM445_RS18935	COG0358	DNA primase activity
AM445_RS18940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM445_RS19010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM445_RS19025	COG4991	sh3 domain protein
AM445_RS19030	COG3025	triphosphatase activity
AM445_RS19050	COG2960	long-chain fatty acid transporting porin activity
AM445_RS19065	COG3384	dioxygenase
AM445_RS19070	COG0754	glutathionylspermidine amidase activity
AM445_RS19085	COG0494	nUDIX hydrolase
AM445_RS19090	COG3151	Protein conserved in bacteria
AM445_RS19095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM445_RS19100	COG3150	esterase
AM445_RS19110	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM445_RS19115	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM445_RS19120	COG0642	Histidine kinase
AM445_RS19130	COG3111	PFAM Bacterial OB fold (BOF) protein
AM445_RS19135	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AM445_RS19145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AM445_RS19150	COG0204	Acyl-transferase
AM445_RS19155	COG2132	Multicopper oxidase
AM445_RS19160	COG1032	radical SAM domain protein
AM445_RS19170	COG0656	L-ascorbic acid biosynthetic process
AM445_RS19175	COG1979	alcohol dehydrogenase
AM445_RS19180	COG2207	Transcriptional regulator
AM445_RS19185	COG0586	Pfam SNARE associated Golgi protein
AM445_RS19190	COG0626	cystathionine gamma-synthase activity
AM445_RS19205	COG0848	biopolymer transport protein
AM445_RS19210	COG2211	Major facilitator Superfamily
AM445_RS19235	COG0625	glutathione transferase activity
AM445_RS19245	COG0754	glutathionylspermidine amidase activity
AM445_RS19250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM445_RS19270	COG0583	DNA-binding transcription factor activity
AM445_RS19275	COG0626	cystathionine gamma-synthase activity
AM445_RS19290	COG3121	Chaperone
AM445_RS19305	COG3121	Chaperone
AM445_RS19310	COG3121	Chaperone
AM445_RS19315	COG3188	usher protein
AM445_RS19345	COG1811	Na channel or pump
AM445_RS19355	COG1982	Orn Lys Arg decarboxylase major
AM445_RS19360	COG2211	Major facilitator Superfamily
AM445_RS19375	COG1194	a g-specific adenine glycosylase
AM445_RS19385	COG3171	Protein conserved in bacteria
AM445_RS19395	COG4214	carbohydrate transport
AM445_RS19410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM445_RS19425	COG0762	integral membrane protein
AM445_RS19430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AM445_RS19435	COG2805	Type II/IV secretion system protein
AM445_RS19455	COG0189	ligase activity
AM445_RS19460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM445_RS19465	COG2356	endonuclease I
AM445_RS19475	COG2814	Major facilitator Superfamily
AM445_RS19510	COG0501	Belongs to the peptidase M48B family
AM445_RS19515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM445_RS19530	COG0191	fructose-bisphosphate aldolase activity
AM445_RS19535	COG0668	transmembrane transport
AM445_RS19545	COG2968	Membrane
AM445_RS19560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM445_RS19565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM445_RS19585	COG0006	proline dipeptidase activity
AM445_RS19590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM445_RS19595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM445_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS19620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM445_RS19640	COG2723	6-phospho-beta-galactosidase activity
AM445_RS19645	COG1737	Transcriptional regulator
AM445_RS19655	COG1272	protein, Hemolysin III
AM445_RS19665	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AM445_RS19675	COG0716	FMN binding
AM445_RS19680	COG4974	Belongs to the 'phage' integrase family
AM445_RS19690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM445_RS19710	COG1811	Na channel or pump
AM445_RS19720	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM445_RS19725	COG0583	DNA-binding transcription factor activity
AM445_RS19730	COG4942	peptidase
AM445_RS19740	COG2814	Major facilitator Superfamily
AM445_RS19755	COG0667	Aldo Keto reductase
AM445_RS19795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM445_RS19800	COG1393	Belongs to the ArsC family
AM445_RS19815	COG1538	Outer membrane efflux protein
AM445_RS19820	COG1289	transmembrane transporter activity
AM445_RS19835	COG3592	Divergent 4Fe-4S mono-cluster
AM445_RS19840	COG2388	GCN5-related N-acetyl-transferase
AM445_RS19850	COG3539	Fimbrial protein
AM445_RS19855	COG3539	Fimbrial protein
AM445_RS19860	COG3539	Fimbrial protein
AM445_RS19865	COG3188	usher protein
AM445_RS19870	COG3121	Chaperone
AM445_RS19875	COG3539	Fimbrial protein
AM445_RS19885	COG4974	Belongs to the 'phage' integrase family
AM445_RS19890	COG0582	viral genome integration into host DNA
AM445_RS19900	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AM445_RS19905	COG1846	Transcriptional regulator
AM445_RS19910	COG0697	spore germination
AM445_RS19960	COG0667	Aldo Keto reductase
AM445_RS19965	COG0814	amino acid
AM445_RS19980	COG0183	Belongs to the thiolase family
AM445_RS19995	COG0823	Involved in the tonB-independent uptake of proteins
AM445_RS20000	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS20005	COG2814	Major facilitator Superfamily
AM445_RS20035	COG3842	ATPase activity
AM445_RS20040	COG0395	ABC-type sugar transport system, permease component
AM445_RS20045	COG1175	transmembrane transport
AM445_RS20050	COG1917	Cupin 2, conserved barrel domain protein
AM445_RS20055	COG1794	racemase activity, acting on amino acids and derivatives
AM445_RS20060	COG0583	DNA-binding transcription factor activity
AM445_RS20070	COG1609	Transcriptional regulator
AM445_RS20075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS20080	COG2723	6-phospho-beta-galactosidase activity
AM445_RS20085	COG2186	Transcriptional regulator
AM445_RS20095	COG1609	Transcriptional regulator
AM445_RS20120	COG0667	Aldo Keto reductase
AM445_RS20130	COG0861	Integral membrane protein TerC family
AM445_RS20165	COG2165	general secretion pathway protein
AM445_RS20170	COG4795	General secretion pathway protein
AM445_RS20180	COG4967	type IV pilus modification protein PilV
AM445_RS20185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AM445_RS20190	COG1025	Belongs to the peptidase M16 family
AM445_RS20195	COG1074	ATP-dependent DNA helicase activity
AM445_RS20200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM445_RS20210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM445_RS20210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AM445_RS20215	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM445_RS20220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AM445_RS20250	COG4656	Part of a membrane complex involved in electron transport
AM445_RS20255	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS20255	COG1454	alcohol dehydrogenase
AM445_RS20285	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM445_RS20485	COG2885	chlorophyll binding
AM445_RS20520	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AM445_RS20525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM445_RS20530	COG2166	iron-sulfur cluster assembly
AM445_RS20535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM445_RS20545	COG0583	DNA-binding transcription factor activity
AM445_RS20550	COG2363	Small membrane protein
AM445_RS20560	COG1349	DNA-binding transcription factor activity
AM445_RS20580	COG0738	Major facilitator superfamily
AM445_RS20585	COG0235	Class ii aldolase
AM445_RS20590	COG1454	alcohol dehydrogenase
AM445_RS20605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM445_RS20620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM445_RS20625	COG2011	ABC-type metal ion transport system permease component
AM445_RS20630	COG1464	Belongs to the NlpA lipoprotein family
AM445_RS20640	COG0477	Major facilitator Superfamily
AM445_RS20650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM445_RS20655	COG1760	l-serine dehydratase
AM445_RS20660	COG0814	amino acid
AM445_RS20665	COG1611	Belongs to the LOG family
AM445_RS20680	COG3098	single-species biofilm formation
AM445_RS20685	COG0564	pseudouridine synthase activity
AM445_RS20690	COG0716	FMN binding
AM445_RS20695	COG2271	Major facilitator Superfamily
AM445_RS20700	COG4948	Mandelate Racemase Muconate Lactonizing
AM445_RS20705	COG4948	Mandelate Racemase Muconate Lactonizing
AM445_RS20710	COG1929	Belongs to the glycerate kinase type-1 family
AM445_RS20715	COG2205	protein histidine kinase activity
AM445_RS20715	COG3437	response regulator, receiver
AM445_RS20715	COG4999	Histidine kinase
AM445_RS20715	COG3850	Histidine kinase
AM445_RS20725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM445_RS20730	COG3956	TIGRFAM MazG family protein
AM445_RS20750	COG0602	queuosine metabolic process
AM445_RS20755	COG0720	synthase
AM445_RS20775	COG2234	aminopeptidase activity
AM445_RS20835	COG4942	peptidase
AM445_RS20835	COG1388	LysM domain
AM445_RS20840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM445_RS20865	COG0163	prenyltransferase activity
AM445_RS20870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM445_RS20915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS20920	COG4558	Periplasmic binding protein
AM445_RS20925	COG3720	iron ion transport
AM445_RS20945	COG0679	Auxin Efflux Carrier
AM445_RS20960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM445_RS20965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM445_RS20970	COG1121	(ABC) transporter
AM445_RS20975	COG0803	Belongs to the bacterial solute-binding protein 9 family
AM445_RS20980	COG1609	Transcriptional regulator
AM445_RS20985	COG1940	carbohydrate kinase activity
AM445_RS20990	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM445_RS20995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS21000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS21005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM445_RS21015	COG4580	involved in the transport of maltose and maltodextrins
AM445_RS21025	COG2723	6-phospho-beta-galactosidase activity
AM445_RS21035	COG0309	Hydrogenase expression formation protein (HypE)
AM445_RS21040	COG0409	Hydrogenase expression formation protein
AM445_RS21045	COG0298	carbon dioxide binding
AM445_RS21050	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AM445_RS21070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM445_RS21075	COG0651	ATP synthesis coupled electron transport
AM445_RS21080	COG0650	Formate hydrogenlyase subunit 4
AM445_RS21085	COG3261	NADH dehydrogenase
AM445_RS21085	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AM445_RS21090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM445_RS21095	COG3260	NADH ubiquinone oxidoreductase 20
AM445_RS21105	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AM445_RS21115	COG2723	6-phospho-beta-galactosidase activity
AM445_RS21120	COG1263	PTS System
AM445_RS21120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM445_RS21125	COG1609	Transcriptional regulator
AM445_RS21130	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM445_RS21135	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AM445_RS21140	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AM445_RS21170	COG1349	DNA-binding transcription factor activity
AM445_RS21175	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS21180	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS21190	COG3732	PTS system glucitol sorbitol-specific
AM445_RS21195	COG3730	PTS system glucitol sorbitol-specific
AM445_RS21200	COG2951	lytic endotransglycosylase activity
AM445_RS21210	COG1121	(ABC) transporter
AM445_RS21215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM445_RS21225	COG1546	Belongs to the CinA family
AM445_RS21250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AM445_RS21280	COG2823	Periplasmic or secreted lipoprotein
AM445_RS21285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM445_RS21290	COG1238	metal cluster binding
AM445_RS21310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM445_RS21315	COG2814	Major facilitator Superfamily
AM445_RS21320	COG1566	PFAM secretion protein HlyD family protein
AM445_RS21325	COG1846	Transcriptional regulator
AM445_RS21335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM445_RS21345	COG4176	ABC-type proline glycine betaine transport system permease component
AM445_RS21360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM445_RS21370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM445_RS21375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM445_RS21380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM445_RS21385	COG4575	ribosome binding
AM445_RS21410	COG2916	Histone family protein nucleoid-structuring protein H-NS
AM445_RS21425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AM445_RS21430	COG0640	Transcriptional regulator
AM445_RS21440	COG0583	DNA-binding transcription factor activity
AM445_RS21445	COG3284	Transcriptional regulator
AM445_RS21455	COG3539	Fimbrial protein
AM445_RS21460	COG3121	Chaperone
AM445_RS21480	COG3188	usher protein
AM445_RS21490	COG3539	Fimbrial protein
AM445_RS21495	COG2197	response regulator
AM445_RS21510	COG1028	Short-chain dehydrogenase reductase Sdr
AM445_RS21520	COG0235	Class ii aldolase
AM445_RS21530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS21565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS21570	COG3708	Transcriptional regulator
AM445_RS21570	COG2207	Transcriptional regulator
AM445_RS21600	COG2867	negative regulation of translational initiation
AM445_RS21615	COG0497	DNA recombination
AM445_RS21635	COG4536	flavin adenine dinucleotide binding
AM445_RS21640	COG4137	Cytochrome C assembly protein
AM445_RS21645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM445_RS21680	COG2885	chlorophyll binding
AM445_RS21685	COG2199	diguanylate cyclase activity
AM445_RS21695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM445_RS21700	COG1605	Chorismate mutase
AM445_RS21700	COG0287	Prephenate dehydrogenase
AM445_RS21710	COG1605	Chorismate mutase
AM445_RS21710	COG0077	Prephenate dehydratase
AM445_RS21720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM445_RS21725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM445_RS21740	COG0542	response to heat
AM445_RS21765	COG0477	Major facilitator Superfamily
AM445_RS21770	COG5544	Lipoprotein
AM445_RS21775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM445_RS21785	COG3148	PFAM DTW domain containing protein
AM445_RS21790	COG3118	belongs to the thioredoxin family
AM445_RS21795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM445_RS21810	COG0513	Belongs to the DEAD box helicase family
AM445_RS21820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AM445_RS21830	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AM445_RS21835	COG3026	antisigma factor binding
AM445_RS21840	COG3086	response to oxidative stress
AM445_RS21880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM445_RS21935	COG1484	DNA-dependent DNA replication
AM445_RS21990	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
AM445_RS21995	COG0484	heat shock protein binding
AM445_RS22015	COG3179	chitinase
AM445_RS22050	COG3728	DNA packaging
AM445_RS22050	COG5484	DNA packaging
AM445_RS22140	COG1196	nuclear chromosome segregation
AM445_RS22200	COG0681	Belongs to the peptidase S26 family
AM445_RS22220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM445_RS22230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM445_RS22235	COG1737	Transcriptional regulator
AM445_RS22240	COG0560	Phosphoserine phosphatase
AM445_RS22255	COG0047	phosphoribosylformylglycinamidine synthase activity
AM445_RS22255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM445_RS22265	COG2205	protein histidine kinase activity
AM445_RS22270	COG3170	Tfp pilus assembly protein FimV
AM445_RS22275	COG2204	response regulator
AM445_RS22280	COG0347	Belongs to the P(II) protein family
AM445_RS22285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM445_RS22285	COG1017	nitric oxide dioxygenase activity
AM445_RS22300	COG2259	Doxx family
AM445_RS22305	COG1940	carbohydrate kinase activity
AM445_RS22310	COG0457	Tetratricopeptide repeat
AM445_RS22315	COG2814	Major facilitator Superfamily
AM445_RS22315	COG0477	Major facilitator Superfamily
AM445_RS22320	COG2017	converts alpha-aldose to the beta-anomer
AM445_RS22325	COG2814	Major facilitator Superfamily
AM445_RS22330	COG3711	transcriptional antiterminator
AM445_RS22335	COG3683	transport system, periplasmic component
AM445_RS22340	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AM445_RS22370	COG0822	iron-sulfur transferase activity
AM445_RS22390	COG0633	Ferredoxin
AM445_RS22395	COG2975	iron-sulfur cluster assembly
AM445_RS22415	COG2897	thiosulfate sulfurtransferase activity
AM445_RS22420	COG2373	Large extracellular alpha-helical protein
AM445_RS22425	COG4953	penicillin-binding protein 1C
AM445_RS22460	COG2976	Protein conserved in bacteria
AM445_RS22580	COG0758	DNA mediated transformation
AM445_RS22580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM445_RS22605	COG1645	bacterial-type flagellum-dependent swarming motility
AM445_RS22615	COG0517	IMP dehydrogenase activity
AM445_RS22615	COG0516	GMP reductase activity
AM445_RS22625	COG3119	arylsulfatase activity
AM445_RS22630	COG0641	radical SAM
AM445_RS22650	COG2200	EAL domain
AM445_RS22665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM445_RS22680	COG2723	6-phospho-beta-galactosidase activity
AM445_RS22690	COG2233	PERMEase
AM445_RS22705	COG1393	Belongs to the ArsC family
AM445_RS22710	COG4783	chaperone-mediated protein folding
AM445_RS22715	COG0628	permease
AM445_RS22720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM445_RS22725	COG2716	regulation of RNA biosynthetic process
AM445_RS22735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AM445_RS22745	COG2321	neutral zinc metallopeptidase
AM445_RS22750	COG1444	tRNA N-acetyltransferase activity
AM445_RS22755	COG0400	carboxylic ester hydrolase activity
AM445_RS22770	COG1393	Belongs to the ArsC family
AM445_RS22780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM445_RS22790	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM445_RS22790	COG0493	'glutamate synthase
AM445_RS22800	COG5342	invasion associated locus B
AM445_RS22805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM445_RS22810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM445_RS22820	COG4810	utilization protein
AM445_RS22910	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM445_RS22930	COG2837	iron assimilation
AM445_RS22940	COG4150	thiosulfate binding
AM445_RS22945	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AM445_RS22950	COG4208	sulfate ABC transporter
AM445_RS22955	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM445_RS22965	COG4319	ketosteroid isomerase
AM445_RS23000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM445_RS23020	COG3530	Putative quorum-sensing-regulated virulence factor
AM445_RS23025	COG0385	Bile acid
AM445_RS23030	COG0583	DNA-binding transcription factor activity
AM445_RS23065	COG3415	Transposase
AM445_RS23070	COG3415	Transposase
AM445_RS23080	COG2200	EAL domain
AM445_RS23080	COG2199	diguanylate cyclase activity
AM445_RS23085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM445_RS23100	COG0667	Aldo Keto reductase
AM445_RS23105	COG3961	Belongs to the TPP enzyme family
AM445_RS23120	COG3279	Response regulator of the LytR AlgR family
AM445_RS23125	COG3275	phosphorelay sensor kinase activity
AM445_RS23135	COG0436	Aminotransferase
AM445_RS23145	COG2807	transmembrane transport
AM445_RS23150	COG0590	tRNA wobble adenosine to inosine editing
AM445_RS23155	COG0583	DNA-binding transcription factor activity
AM445_RS23175	COG0582	viral genome integration into host DNA
AM445_RS23270	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
AM445_RS23275	COG1403	HNH endonuclease
AM445_RS23320	COG3179	chitinase
AM445_RS23475	COG3344	reverse transcriptase
AM445_RS23490	COG2116	formate transmembrane transporter activity
AM445_RS23495	COG2853	Lipoprotein
AM445_RS23510	COG3691	Protein conserved in bacteria
AM445_RS23525	COG2062	phosphohistidine phosphatase, SixA
AM445_RS23550	COG0730	response to heat
AM445_RS23555	COG3101	peptidyl-lysine hydroxylation
AM445_RS23570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM445_RS23590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM445_RS23600	COG0586	Pfam SNARE associated Golgi protein
AM445_RS23610	COG0285	dihydrofolate synthase activity
AM445_RS23615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AM445_RS23620	COG1286	toxin biosynthetic process
AM445_RS23625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AM445_RS23630	COG0163	prenyltransferase activity
AM445_RS23650	COG4160	amino acid transport
AM445_RS23655	COG4598	ABC transporter
AM445_RS23665	COG1090	epimerase
AM445_RS23670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM445_RS23675	COG0625	glutathione transferase activity
AM445_RS23680	COG0625	glutathione transferase activity
AM445_RS23685	COG0622	Phosphoesterase
AM445_RS23690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AM445_RS23695	COG0280	phosphate acetyltransferase
AM445_RS23695	COG0857	belongs to the CobB CobQ family
AM445_RS23715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM445_RS23720	COG0490	domain, Protein
AM445_RS23720	COG0471	metal ion transport
AM445_RS23730	COG0436	Aminotransferase
AM445_RS23735	COG0583	DNA-binding transcription factor activity
AM445_RS23790	COG0839	Belongs to the complex I subunit 6 family
AM445_RS23800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM445_RS23805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM445_RS23820	COG2153	protein acetylation
AM445_RS23825	COG1169	isochorismate synthase
AM445_RS23850	COG0318	PFAM AMP-dependent synthetase and ligase
AM445_RS23860	COG5464	transposase or invertase
AM445_RS23880	COG1414	Transcriptional regulator
AM445_RS23890	COG2271	Major facilitator Superfamily
AM445_RS23900	COG0247	lactate metabolic process
AM445_RS23910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM445_RS23915	COG2271	Major facilitator Superfamily
AM445_RS23930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM445_RS23960	COG2205	protein histidine kinase activity
AM445_RS23960	COG0784	Response regulator, receiver
AM445_RS23970	COG2198	Histidine kinase
AM445_RS23970	COG0642	Histidine kinase
AM445_RS23985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM445_RS23985	COG2169	Transcriptional regulator
AM445_RS23990	COG3145	DNA-N1-methyladenine dioxygenase activity
AM445_RS23995	COG4615	Cyclic peptide transporter
AM445_RS24000	COG2239	Acts as a magnesium transporter
AM445_RS24005	COG0659	secondary active sulfate transmembrane transporter activity
AM445_RS24020	COG0628	permease
AM445_RS24045	COG1349	DNA-binding transcription factor activity
AM445_RS24050	COG0494	nUDIX hydrolase
AM445_RS24070	COG1061	Type III restriction enzyme res subunit
AM445_RS24075	COG1187	pseudouridine synthase activity
AM445_RS24080	COG2814	Major facilitator Superfamily
AM445_RS24090	COG4172	Belongs to the ABC transporter superfamily
AM445_RS24095	COG4239	(ABC) transporter, permease
AM445_RS24100	COG4174	ABC transporter (Permease)
AM445_RS24105	COG4166	transmembrane transport
AM445_RS24110	COG2200	EAL domain
AM445_RS24115	COG0791	NLP P60 protein
AM445_RS24120	COG0671	phosphoesterase, PA-phosphatase related
AM445_RS24125	COG0523	cobalamin synthesis protein
AM445_RS24130	COG0246	Mannitol dehydrogenase
AM445_RS24135	COG1312	Catalyzes the dehydration of D-mannonate
AM445_RS24160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS24160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS24165	COG1105	Belongs to the carbohydrate kinase PfkB family
AM445_RS24170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS24170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM445_RS24170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM445_RS24180	COG2855	membrane
AM445_RS24190	COG0583	DNA-binding transcription factor activity
AM445_RS24195	COG0833	amino acid
AM445_RS24205	COG4771	TonB-dependent receptor
AM445_RS24220	COG2311	Membrane
AM445_RS24235	COG1129	ABC transporter
AM445_RS24245	COG2949	membrane
AM445_RS24260	COG1346	cytolysis
AM445_RS24270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM445_RS24275	COG3659	wide pore channel activity
AM445_RS24290	COG2723	6-phospho-beta-galactosidase activity
AM445_RS24300	COG1538	Outer membrane efflux protein
AM445_RS24305	COG0586	Pfam SNARE associated Golgi protein
AM445_RS24315	COG1686	Belongs to the peptidase S11 family
AM445_RS24325	COG0277	FAD linked oxidase domain protein
AM445_RS24330	COG1472	Belongs to the glycosyl hydrolase 3 family
AM445_RS24335	COG1732	Glycine betaine
AM445_RS24340	COG1174	glycine betaine transport
AM445_RS24345	COG1125	glycine betaine transport
AM445_RS24350	COG1174	glycine betaine transport
AM445_RS24360	COG3275	phosphorelay sensor kinase activity
AM445_RS24370	COG4807	Protein conserved in bacteria
AM445_RS24390	COG5455	response to cobalt ion
AM445_RS24395	COG0583	DNA-binding transcription factor activity
AM445_RS24400	COG2252	PERMEase
AM445_RS24410	COG0583	DNA-binding transcription factor activity
AM445_RS24425	COG0351	phosphomethylpyrimidine kinase
AM445_RS24430	COG1830	Aldolase
AM445_RS24465	COG1070	Carbohydrate kinase
AM445_RS24475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM445_RS24480	COG4948	Mandelate Racemase Muconate Lactonizing
AM445_RS24490	COG0601	transmembrane transport
AM445_RS24495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS24500	COG0444	Belongs to the ABC transporter superfamily
AM445_RS24505	COG4608	Belongs to the ABC transporter superfamily
AM445_RS24515	COG0826	peptidase U32
AM445_RS24520	COG0745	RESPONSE REGULATOR receiver
AM445_RS24525	COG2205	protein histidine kinase activity
AM445_RS24550	COG1301	dicarboxylic acid transport
AM445_RS24565	COG5002	protein histidine kinase activity
AM445_RS24570	COG0443	Heat shock 70 kDa protein
AM445_RS24580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AM445_RS24595	COG2982	Protein involved in outer membrane biogenesis
AM445_RS24600	COG1253	flavin adenine dinucleotide binding
AM445_RS24745	COG1215	transferase activity, transferring glycosyl groups
AM445_RS24765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM445_RS24795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM445_RS24800	COG0583	DNA-binding transcription factor activity
AM445_RS24810	COG0531	amino acid
AM445_RS24815	COG0640	Transcriptional regulator
AM445_RS24820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM445_RS24825	COG2925	Exonuclease
AM445_RS24840	COG3344	reverse transcriptase
AM445_RS24850	COG1289	transmembrane transporter activity
AM445_RS24870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM445_RS24880	COG1942	4-Oxalocrotonate Tautomerase
AM445_RS24885	COG0583	DNA-binding transcription factor activity
AM445_RS24890	COG0095	Lipoate-protein ligase
AM445_RS24895	COG0477	Major facilitator Superfamily
AM445_RS24910	COG5001	Diguanylate cyclase
AM445_RS24910	COG3300	MHYT domain
AM445_RS24920	COG3615	Tellurite resistance protein tehB
AM445_RS24945	COG3706	GGDEF domain
AM445_RS24975	COG3621	Patatin-like phospholipase
AM445_RS25065	COG3504	Conjugal transfer protein
AM445_RS25140	COG4771	TonB-dependent receptor
AM445_RS25145	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM445_RS25165	COG2226	methyltransferase
AM445_RS25165	COG3433	isochorismatase activity
AM445_RS25165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM445_RS25180	COG1132	(ABC) transporter
AM445_RS25185	COG2814	Major facilitator Superfamily
AM445_RS25190	COG1169	isochorismate synthase
AM445_RS25195	COG0582	viral genome integration into host DNA
AM445_RS25205	COG0534	Mate efflux family protein
AM445_RS25215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM445_RS25235	COG0604	alcohol dehydrogenase
AM445_RS25240	COG1309	transcriptional regulator
AM445_RS25245	COG0025	NhaP-type Na H and K H
AM445_RS25295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM445_RS25305	COG1418	mRNA catabolic process
AM445_RS25310	COG0270	DNA (cytosine-5-)-methyltransferase activity
AM445_RS25315	COG3727	T/G mismatch-specific endonuclease activity
AM445_RS25320	COG0697	spore germination
AM445_RS25325	COG2354	Protein conserved in bacteria
AM445_RS25355	COG0366	Alpha amylase catalytic
AM445_RS25360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM445_RS25370	COG0765	amino acid transport
AM445_RS25375	COG1126	abc transporter atp-binding protein
AM445_RS25380	COG2197	response regulator
AM445_RS25390	COG2197	response regulator
AM445_RS25425	COG3012	SEC-C Motif Domain Protein
AM445_RS25425	COG3318	Belongs to the UPF0149 family
AM445_RS25430	COG0814	amino acid
AM445_RS25440	COG1528	Iron-storage protein
AM445_RS25455	COG0477	Major facilitator Superfamily
AM445_RS25465	COG2211	Major facilitator Superfamily
AM445_RS25475	COG1528	Iron-storage protein
AM445_RS25485	COG1879	ABC-type sugar transport system periplasmic component
AM445_RS25495	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM445_RS25520	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AM445_RS25530	COG3102	Protein conserved in bacteria
AM445_RS25550	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AM445_RS25555	COG1801	Protein of unknown function DUF72
AM445_RS25560	COG0582	viral genome integration into host DNA
AM445_RS25725	COG3772	lysozyme
AM445_RS25885	COG3344	reverse transcriptase
AM445_RS25900	COG1335	isochorismatase
AM445_RS25910	COG0494	nUDIX hydrolase
AM445_RS25935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM445_RS25945	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AM445_RS25950	COG0739	heme binding
AM445_RS25955	COG1560	Kdo2-lipid A biosynthetic process
AM445_RS25965	COG1737	Transcriptional regulator
AM445_RS25980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM445_RS25985	COG0129	dihydroxy-acid dehydratase activity
AM445_RS25990	COG0800	Aldolase
AM445_RS26000	COG3141	response to X-ray
AM445_RS26005	COG2979	Protein of unknown function (DUF533)
AM445_RS26010	COG1770	oligopeptidase
AM445_RS26015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM445_RS26025	COG2372	response to copper ion
AM445_RS26030	COG1276	copper resistance
AM445_RS26045	COG2990	Protein conserved in bacteria
AM445_RS26070	COG3008	intermembrane lipid transfer
AM445_RS26075	COG2995	paraquat-inducible protein a
AM445_RS26080	COG1956	GAF domain-containing protein
AM445_RS26110	COG1414	Transcriptional regulator
AM445_RS26150	COG0768	penicillin binding
AM445_RS26155	COG2226	methyltransferase
AM445_RS26170	COG3716	PTS system mannose fructose sorbose family IID component
AM445_RS26175	COG3715	PTS system
AM445_RS26180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM445_RS26180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM445_RS26185	COG1253	flavin adenine dinucleotide binding
AM445_RS26190	COG2200	EAL domain
AM445_RS26195	COG1760	l-serine dehydratase
AM445_RS26215	COG0251	oxidation-reduction process
AM445_RS26220	COG1199	ATP-dependent helicase activity
AM445_RS26240	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AM445_RS26250	COG2894	cell division
AM445_RS26265	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM445_RS26295	COG2719	SpoVR family
AM445_RS26315	COG1619	proteins homologs of microcin C7 resistance protein MccF
AM445_RS26325	COG4774	siderophore transport
AM445_RS26340	COG2308	Evidence 4 Homologs of previously reported genes of
AM445_RS26390	COG0583	DNA-binding transcription factor activity
AM445_RS26395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM445_RS26410	COG1882	Formate acetyltransferase
AM445_RS26440	COG0583	DNA-binding transcription factor activity
AM445_RS26470	COG0583	DNA-binding transcription factor activity
AM445_RS26485	COG3122	Protein conserved in bacteria
AM445_RS26515	COG2885	chlorophyll binding
AM445_RS26535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM445_RS26610	COG0012	GTP binding
AM445_RS26630	COG0659	secondary active sulfate transmembrane transporter activity
AM445_RS26665	COG2890	protein-(glutamine-N5) methyltransferase activity
AM445_RS26685	COG0387	Pfam Sodium calcium exchanger
AM445_RS26690	COG4572	Cation transport regulator
AM445_RS26695	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AM445_RS26705	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AM445_RS26710	COG3707	response regulator
AM445_RS26715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM445_RS26725	COG1116	anion transmembrane transporter activity
AM445_RS26730	COG2146	nitrite reductase [NAD(P)H] activity
AM445_RS26730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM445_RS26735	COG0243	molybdopterin cofactor binding
AM445_RS26740	COG4932	domain protein
AM445_RS26745	COG2197	response regulator
AM445_RS26750	COG3850	Histidine kinase
AM445_RS26755	COG2223	nitrite transmembrane transporter activity
AM445_RS26760	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AM445_RS26765	COG1140	nitrate reductase beta subunit
AM445_RS26770	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AM445_RS26775	COG2181	nitrate reductase activity
AM445_RS26785	COG1522	sequence-specific DNA binding
AM445_RS26830	COG0788	formyltetrahydrofolate deformylase activity
AM445_RS26840	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM445_RS26845	COG0745	RESPONSE REGULATOR receiver
AM445_RS26850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM445_RS26855	COG2916	Histone family protein nucleoid-structuring protein H-NS
AM445_RS26860	COG1435	thymidine kinase activity
AM445_RS26865	COG1454	alcohol dehydrogenase
AM445_RS26865	COG1012	belongs to the aldehyde dehydrogenase family
AM445_RS26875	COG2095	MarC family integral membrane protein
AM445_RS26880	COG4166	transmembrane transport
AM445_RS26885	COG0601	transmembrane transport
AM445_RS26890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS26895	COG0444	Belongs to the ABC transporter superfamily
AM445_RS26905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM445_RS26925	COG2353	YceI-like domain
AM445_RS26930	COG2350	Protein conserved in bacteria
AM445_RS26940	COG3001	Fructosamine kinase
AM445_RS26950	COG1105	Belongs to the carbohydrate kinase PfkB family
AM445_RS26955	COG3137	Salt-induced outer membrane protein
AM445_RS26995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM445_RS26995	COG0072	phenylalanine-tRNA ligase activity
AM445_RS27015	COG0583	DNA-binding transcription factor activity
AM445_RS27035	COG0386	Belongs to the glutathione peroxidase family
AM445_RS27045	COG0791	NLP P60 protein
AM445_RS27055	COG4256	Hemin uptake protein
AM445_RS27060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM445_RS27070	COG0574	Belongs to the PEP-utilizing enzyme family
AM445_RS27070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM445_RS27080	COG0628	permease
AM445_RS27085	COG0247	lactate metabolic process
AM445_RS27085	COG0277	FAD linked oxidase domain protein
AM445_RS27090	COG2050	protein possibly involved in aromatic compounds catabolism
AM445_RS27095	COG2261	transglycosylase associated protein
AM445_RS27125	COG1120	ATPase activity
AM445_RS27130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS27140	COG0583	DNA-binding transcription factor activity
AM445_RS27165	COG1304	FMN binding
AM445_RS27170	COG1309	transcriptional regulator
AM445_RS27185	COG0316	Belongs to the HesB IscA family
AM445_RS27190	COG0719	Fe-S assembly protein
AM445_RS27195	COG0396	ATPase activity
AM445_RS27200	COG0719	Fe-S assembly protein
AM445_RS27215	COG1376	ErfK ybiS ycfS ynhG family protein
AM445_RS27240	COG1309	transcriptional regulator
AM445_RS27245	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AM445_RS27245	COG1082	Xylose isomerase domain protein TIM barrel
AM445_RS27250	COG2271	Major facilitator Superfamily
AM445_RS27280	COG3436	PFAM IS66 Orf2 family protein
AM445_RS27285	COG1120	ATPase activity
AM445_RS27290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS27295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM445_RS27300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AM445_RS27305	COG4772	TonB-dependent receptor
AM445_RS27310	COG3712	iron ion homeostasis
AM445_RS27315	COG1595	DNA-templated transcription, initiation
AM445_RS27345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM445_RS27350	COG0601	transmembrane transport
AM445_RS27365	COG4172	Belongs to the ABC transporter superfamily
AM445_RS27485	COG0071	Belongs to the small heat shock protein (HSP20) family
AM445_RS27490	COG0542	response to heat
AM445_RS27510	COG0501	Belongs to the peptidase M48B family
AM445_RS27520	COG2801	Transposase and inactivated derivatives
AM445_RS27585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM445_RS27615	COG0431	NADPH-dependent FMN reductase
AM445_RS27630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AM445_RS27660	COG3436	PFAM IS66 Orf2 family protein
AM445_RS27665	COG4372	Transposase
AM445_RS27670	COG2205	protein histidine kinase activity
AM445_RS27675	COG0745	RESPONSE REGULATOR receiver
AM445_RS27680	COG1276	copper resistance
AM445_RS27685	COG2372	response to copper ion
AM445_RS27690	COG3667	copper resistance
AM445_RS27695	COG2132	Multicopper oxidase
AM445_RS27705	COG0739	heme binding
AM445_RS27735	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM445_RS27770	COG3436	PFAM IS66 Orf2 family protein
AM445_RS27775	COG4372	Transposase
AM445_RS27805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM445_RS27815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM445_RS27835	COG1716	ATPase activity
AM445_RS27835	COG5001	Diguanylate cyclase
AM445_RS27840	COG2203	Gaf domain
AM445_RS27840	COG2199	diguanylate cyclase activity
AM445_RS27905	COG3344	reverse transcriptase
AM445_RS28065	COG5499	transcription regulator containing HTH domain
AM445_RS28290	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AM445_RS28315	COG3012	SEC-C Motif Domain Protein
AM445_RS28315	COG3318	Belongs to the UPF0149 family
AM445_RS28320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AM445_RS28375	COG3436	PFAM IS66 Orf2 family protein
AM445_RS28380	COG4372	Transposase
AM445_RS28440	COG2223	nitrite transmembrane transporter activity
AM445_RS28450	COG1609	Transcriptional regulator
AM445_RS28645	COG0789	Transcriptional regulator
AM445_RS28675	COG3344	reverse transcriptase
AM445_RS28830	COG1660	Displays ATPase and GTPase activities
AM445_RS28855	COG1349	DNA-binding transcription factor activity