locus-tag	class	description
EX353_RS00010	COG3433	isochorismatase activity
EX353_RS00010	COG2226	methyltransferase
EX353_RS00010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EX353_RS00025	COG1132	(ABC) transporter
EX353_RS00030	COG2814	Major facilitator Superfamily
EX353_RS00035	COG1169	isochorismate synthase
EX353_RS00040	COG0582	viral genome integration into host DNA
EX353_RS00060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EX353_RS00075	COG1418	mRNA catabolic process
EX353_RS00080	COG0270	DNA (cytosine-5-)-methyltransferase activity
EX353_RS00085	COG3727	T/G mismatch-specific endonuclease activity
EX353_RS00090	COG0697	spore germination
EX353_RS00095	COG2354	Protein conserved in bacteria
EX353_RS00125	COG0366	Alpha amylase catalytic
EX353_RS00130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS00140	COG0765	amino acid transport
EX353_RS00145	COG1126	abc transporter atp-binding protein
EX353_RS00150	COG2197	response regulator
EX353_RS00160	COG2197	response regulator
EX353_RS00195	COG3318	Belongs to the UPF0149 family
EX353_RS00195	COG3012	SEC-C Motif Domain Protein
EX353_RS00200	COG0814	amino acid
EX353_RS00210	COG1528	Iron-storage protein
EX353_RS00225	COG0477	Major facilitator Superfamily
EX353_RS00235	COG2211	Major facilitator Superfamily
EX353_RS00245	COG1528	Iron-storage protein
EX353_RS00255	COG1879	ABC-type sugar transport system periplasmic component
EX353_RS00265	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS00290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EX353_RS00300	COG3102	Protein conserved in bacteria
EX353_RS00320	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EX353_RS00325	COG1801	Protein of unknown function DUF72
EX353_RS00330	COG1335	isochorismatase
EX353_RS00340	COG0494	nUDIX hydrolase
EX353_RS00365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EX353_RS00375	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EX353_RS00380	COG0739	heme binding
EX353_RS00385	COG1560	Kdo2-lipid A biosynthetic process
EX353_RS00395	COG1737	Transcriptional regulator
EX353_RS00410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EX353_RS00415	COG0129	dihydroxy-acid dehydratase activity
EX353_RS00420	COG0800	Aldolase
EX353_RS00430	COG3141	response to X-ray
EX353_RS00435	COG2979	Protein of unknown function (DUF533)
EX353_RS00440	COG1770	oligopeptidase
EX353_RS00445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EX353_RS00455	COG2372	response to copper ion
EX353_RS00460	COG1276	copper resistance
EX353_RS00475	COG2990	Protein conserved in bacteria
EX353_RS00500	COG3008	intermembrane lipid transfer
EX353_RS00505	COG2995	paraquat-inducible protein a
EX353_RS00510	COG1956	GAF domain-containing protein
EX353_RS00530	COG2814	Major facilitator Superfamily
EX353_RS00540	COG1414	Transcriptional regulator
EX353_RS00580	COG0768	penicillin binding
EX353_RS00585	COG2226	methyltransferase
EX353_RS00600	COG3716	PTS system mannose fructose sorbose family IID component
EX353_RS00605	COG3715	PTS system
EX353_RS00610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS00610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS00615	COG1253	flavin adenine dinucleotide binding
EX353_RS00620	COG2200	EAL domain
EX353_RS00625	COG1760	l-serine dehydratase
EX353_RS00645	COG0251	oxidation-reduction process
EX353_RS00650	COG1199	ATP-dependent helicase activity
EX353_RS00660	COG3065	identical protein binding
EX353_RS00670	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EX353_RS00680	COG2894	cell division
EX353_RS00695	COG0179	Fumarylacetoacetate (FAA) hydrolase
EX353_RS00725	COG2719	SpoVR family
EX353_RS00745	COG1619	proteins homologs of microcin C7 resistance protein MccF
EX353_RS00755	COG4774	siderophore transport
EX353_RS00770	COG2308	Evidence 4 Homologs of previously reported genes of
EX353_RS00815	COG0583	DNA-binding transcription factor activity
EX353_RS00820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EX353_RS00835	COG1882	Formate acetyltransferase
EX353_RS00865	COG0583	DNA-binding transcription factor activity
EX353_RS00900	COG0582	viral genome integration into host DNA
EX353_RS00995	COG0305	Participates in initiation and elongation during chromosome replication
EX353_RS01090	COG3772	lysozyme
EX353_RS01105	COG5410	chromosome segregation
EX353_RS01170	COG3646	Phage regulatory protein
EX353_RS01180	COG1196	nuclear chromosome segregation
EX353_RS01180	COG0741	lytic transglycosylase activity
EX353_RS01180	COG0739	heme binding
EX353_RS01285	COG3122	Protein conserved in bacteria
EX353_RS01310	COG2885	chlorophyll binding
EX353_RS01335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EX353_RS01345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EX353_RS01410	COG0012	GTP binding
EX353_RS01430	COG0659	secondary active sulfate transmembrane transporter activity
EX353_RS01460	COG2890	protein-(glutamine-N5) methyltransferase activity
EX353_RS01480	COG0387	Pfam Sodium calcium exchanger
EX353_RS01485	COG4572	Cation transport regulator
EX353_RS01490	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EX353_RS01500	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EX353_RS01505	COG3707	response regulator
EX353_RS01510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EX353_RS01520	COG1116	anion transmembrane transporter activity
EX353_RS01525	COG2146	nitrite reductase [NAD(P)H] activity
EX353_RS01525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EX353_RS01530	COG0243	molybdopterin cofactor binding
EX353_RS01535	COG4932	domain protein
EX353_RS01540	COG2197	response regulator
EX353_RS01545	COG3850	Histidine kinase
EX353_RS01550	COG2223	nitrite transmembrane transporter activity
EX353_RS01555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EX353_RS01560	COG1140	nitrate reductase beta subunit
EX353_RS01565	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EX353_RS01570	COG2181	nitrate reductase activity
EX353_RS01580	COG1522	sequence-specific DNA binding
EX353_RS01615	COG0788	formyltetrahydrofolate deformylase activity
EX353_RS01625	COG1752	Esterase of the alpha-beta hydrolase superfamily
EX353_RS01630	COG0745	RESPONSE REGULATOR receiver
EX353_RS01635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EX353_RS01640	COG2916	Histone family protein nucleoid-structuring protein H-NS
EX353_RS01645	COG1435	thymidine kinase activity
EX353_RS01650	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS01650	COG1454	alcohol dehydrogenase
EX353_RS01660	COG2095	MarC family integral membrane protein
EX353_RS01665	COG4166	transmembrane transport
EX353_RS01670	COG0601	transmembrane transport
EX353_RS01675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS01680	COG0444	Belongs to the ABC transporter superfamily
EX353_RS01690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EX353_RS01710	COG2353	YceI-like domain
EX353_RS01715	COG2350	Protein conserved in bacteria
EX353_RS01725	COG3001	Fructosamine kinase
EX353_RS01735	COG1105	Belongs to the carbohydrate kinase PfkB family
EX353_RS01740	COG3137	Salt-induced outer membrane protein
EX353_RS01785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EX353_RS01785	COG0072	phenylalanine-tRNA ligase activity
EX353_RS01805	COG0583	DNA-binding transcription factor activity
EX353_RS01825	COG0386	Belongs to the glutathione peroxidase family
EX353_RS01835	COG0791	NLP P60 protein
EX353_RS01845	COG4256	Hemin uptake protein
EX353_RS01850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EX353_RS01860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EX353_RS01860	COG0574	Belongs to the PEP-utilizing enzyme family
EX353_RS01870	COG0628	permease
EX353_RS01875	COG0277	FAD linked oxidase domain protein
EX353_RS01875	COG0247	lactate metabolic process
EX353_RS01880	COG2050	protein possibly involved in aromatic compounds catabolism
EX353_RS01885	COG2261	transglycosylase associated protein
EX353_RS01915	COG1120	ATPase activity
EX353_RS01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS01930	COG0583	DNA-binding transcription factor activity
EX353_RS01955	COG1304	FMN binding
EX353_RS01960	COG1309	transcriptional regulator
EX353_RS01975	COG0316	Belongs to the HesB IscA family
EX353_RS01980	COG0719	Fe-S assembly protein
EX353_RS01985	COG0396	ATPase activity
EX353_RS01990	COG0719	Fe-S assembly protein
EX353_RS02005	COG1376	ErfK ybiS ycfS ynhG family protein
EX353_RS02030	COG1309	transcriptional regulator
EX353_RS02035	COG1082	Xylose isomerase domain protein TIM barrel
EX353_RS02035	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EX353_RS02040	COG2271	Major facilitator Superfamily
EX353_RS02045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EX353_RS02055	COG1120	ATPase activity
EX353_RS02060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS02065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EX353_RS02070	COG1414	Transcriptional regulator
EX353_RS02105	COG2814	Major facilitator Superfamily
EX353_RS02125	COG0583	DNA-binding transcription factor activity
EX353_RS02130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EX353_RS02150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EX353_RS02155	COG1116	anion transmembrane transporter activity
EX353_RS02160	COG4774	siderophore transport
EX353_RS02165	COG1120	ATPase activity
EX353_RS02170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS02175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS02195	COG0765	amino acid transport
EX353_RS02200	COG1126	abc transporter atp-binding protein
EX353_RS02230	COG1473	amidohydrolase
EX353_RS02235	COG3383	formate dehydrogenase (NAD+) activity
EX353_RS02240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EX353_RS02255	COG1175	transmembrane transport
EX353_RS02290	COG1857	crispr-associated protein
EX353_RS02300	COG1518	maintenance of DNA repeat elements
EX353_RS02305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EX353_RS02310	COG3157	Type VI secretion system effector, Hcp
EX353_RS02340	COG4133	protoheme IX ABC transporter activity
EX353_RS02345	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EX353_RS02350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EX353_RS02365	COG1138	Cytochrome C-type biogenesis protein
EX353_RS02370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EX353_RS02375	COG3088	subunit of a heme lyase
EX353_RS02375	COG4235	cytochrome complex assembly
EX353_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS02445	COG2610	gluconate transmembrane transporter activity
EX353_RS02450	COG1250	3-hydroxyacyl-CoA dehydrogenase
EX353_RS02460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EX353_RS02470	COG0583	DNA-binding transcription factor activity
EX353_RS02495	COG0277	FAD linked oxidase domain protein
EX353_RS02500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EX353_RS02525	COG0402	S-adenosylhomocysteine deaminase activity
EX353_RS02585	COG4608	Belongs to the ABC transporter superfamily
EX353_RS02590	COG0444	Belongs to the ABC transporter superfamily
EX353_RS02615	COG0346	lactoylglutathione lyase activity
EX353_RS02620	COG1349	DNA-binding transcription factor activity
EX353_RS02650	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EX353_RS02670	COG0300	oxidoreductase activity
EX353_RS02715	COG0307	riboflavin synthase, alpha
EX353_RS02720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EX353_RS02725	COG2814	Major facilitator Superfamily
EX353_RS02730	COG0583	DNA-binding transcription factor activity
EX353_RS02745	COG2814	Major facilitator Superfamily
EX353_RS02760	COG0791	NLP P60 protein
EX353_RS02765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EX353_RS02775	COG0346	lactoylglutathione lyase activity
EX353_RS02780	COG1902	pentaerythritol trinitrate reductase activity
EX353_RS02785	COG1309	transcriptional regulator
EX353_RS02790	COG3313	Fe-S protein
EX353_RS02795	COG4989	oxidoreductase activity
EX353_RS02800	COG2032	superoxide dismutase activity
EX353_RS02805	COG1289	transmembrane transporter activity
EX353_RS02810	COG1566	PFAM secretion protein HlyD family protein
EX353_RS02825	COG3706	GGDEF domain
EX353_RS02840	COG3895	Periplasmic Protein
EX353_RS02855	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EX353_RS02860	COG0625	glutathione transferase activity
EX353_RS02875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EX353_RS02885	COG4659	FMN binding
EX353_RS02920	COG2723	6-phospho-beta-galactosidase activity
EX353_RS02930	COG0673	inositol 2-dehydrogenase activity
EX353_RS02940	COG2814	Major facilitator Superfamily
EX353_RS02960	COG3038	cytochrome b561
EX353_RS02980	COG0583	DNA-binding transcription factor activity
EX353_RS02985	COG3485	protocatechuate 3,4-dioxygenase
EX353_RS02990	COG3485	protocatechuate 3,4-dioxygenase
EX353_RS02995	COG5383	Protein conserved in bacteria
EX353_RS03000	COG2272	Belongs to the type-B carboxylesterase lipase family
EX353_RS03015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EX353_RS03020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EX353_RS03025	COG1275	C4-dicarboxylate transporter malic acid transport protein
EX353_RS03030	COG0500	methyltransferase
EX353_RS03050	COG3708	Transcriptional regulator
EX353_RS03050	COG2207	Transcriptional regulator
EX353_RS03055	COG3135	benzoate transporter
EX353_RS03060	COG1396	sequence-specific DNA binding
EX353_RS03070	COG0826	peptidase U32
EX353_RS03090	COG1294	oxidase, subunit
EX353_RS03095	COG1271	oxidase subunit
EX353_RS03100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EX353_RS03105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EX353_RS03110	COG3842	ATPase activity
EX353_RS03115	COG1176	ABC-type spermidine putrescine transport system, permease component I
EX353_RS03120	COG1177	transmembrane transport
EX353_RS03125	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS03155	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS03160	COG0747	negative chemotaxis
EX353_RS03170	COG3238	Protein conserved in bacteria
EX353_RS03175	COG1247	-acetyltransferase
EX353_RS03185	COG2130	NADP-dependent
EX353_RS03200	COG3691	Protein conserved in bacteria
EX353_RS03205	COG1228	amidohydrolase
EX353_RS03210	COG4772	TonB-dependent receptor
EX353_RS03235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EX353_RS03240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EX353_RS03245	COG1473	amidohydrolase
EX353_RS03250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EX353_RS03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS03265	COG0765	amino acid transport
EX353_RS03270	COG1126	abc transporter atp-binding protein
EX353_RS03280	COG0625	glutathione transferase activity
EX353_RS03295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EX353_RS03300	COG3842	ATPase activity
EX353_RS03305	COG1840	ABC-type Fe3 transport system, periplasmic component
EX353_RS03310	COG1178	ABC-type Fe3 transport system permease component
EX353_RS03315	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EX353_RS03320	COG2181	nitrate reductase activity
EX353_RS03325	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EX353_RS03330	COG1140	nitrate reductase beta subunit
EX353_RS03335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EX353_RS03340	COG2223	nitrite transmembrane transporter activity
EX353_RS03355	COG1414	Transcriptional regulator
EX353_RS03360	COG4948	Mandelate Racemase Muconate Lactonizing
EX353_RS03365	COG4829	muconolactone delta-isomerase
EX353_RS03370	COG3485	protocatechuate 3,4-dioxygenase
EX353_RS03380	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EX353_RS03400	COG3383	formate dehydrogenase (NAD+) activity
EX353_RS03400	COG0243	molybdopterin cofactor binding
EX353_RS03405	COG3383	formate dehydrogenase (NAD+) activity
EX353_RS03405	COG0243	molybdopterin cofactor binding
EX353_RS03410	COG0437	4 iron, 4 sulfur cluster binding
EX353_RS03415	COG2864	formate dehydrogenase
EX353_RS03430	COG2326	polyphosphate kinase activity
EX353_RS03440	COG2814	Major facilitator Superfamily
EX353_RS03450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EX353_RS03460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS03470	COG0747	negative chemotaxis
EX353_RS03475	COG1064	alcohol dehydrogenase
EX353_RS03490	COG0488	(ABC) transporter
EX353_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS03530	COG3729	General stress protein
EX353_RS03550	COG3685	Protein conserved in bacteria
EX353_RS03560	COG0366	Alpha amylase catalytic
EX353_RS03570	COG2323	membrane
EX353_RS03580	COG3111	PFAM Bacterial OB fold (BOF) protein
EX353_RS03585	COG1764	response to oxidative stress
EX353_RS03610	COG3781	membrane
EX353_RS03615	COG0243	molybdopterin cofactor binding
EX353_RS03620	COG0583	DNA-binding transcription factor activity
EX353_RS03665	COG1447	Phosphotransferase system cellobiose-specific component IIA
EX353_RS03670	COG2814	Major facilitator Superfamily
EX353_RS03680	COG1285	pathogenesis
EX353_RS03685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EX353_RS03695	COG0583	DNA-binding transcription factor activity
EX353_RS03715	COG0519	Catalyzes the synthesis of GMP from XMP
EX353_RS03715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EX353_RS03755	COG0596	Alpha beta hydrolase
EX353_RS03765	COG2205	protein histidine kinase activity
EX353_RS03780	COG0076	glutamate decarboxylase activity
EX353_RS03785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EX353_RS03790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EX353_RS03795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EX353_RS03800	COG1116	anion transmembrane transporter activity
EX353_RS03805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EX353_RS03820	COG0673	inositol 2-dehydrogenase activity
EX353_RS03830	COG1609	Transcriptional regulator
EX353_RS03845	COG2197	response regulator
EX353_RS03860	COG0071	Belongs to the small heat shock protein (HSP20) family
EX353_RS03865	COG1546	Belongs to the CinA family
EX353_RS03870	COG2200	EAL domain
EX353_RS03885	COG2207	Transcriptional regulator
EX353_RS03885	COG3708	Transcriptional regulator
EX353_RS03890	COG2610	gluconate transmembrane transporter activity
EX353_RS03895	COG3622	Belongs to the hyi family
EX353_RS03900	COG0235	Class ii aldolase
EX353_RS03905	COG3395	kinase activity
EX353_RS03910	COG2084	Dehydrogenase
EX353_RS03915	COG1349	DNA-binding transcription factor activity
EX353_RS03930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EX353_RS03935	COG2223	nitrite transmembrane transporter activity
EX353_RS03975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EX353_RS04010	COG2814	Major facilitator Superfamily
EX353_RS04015	COG0697	spore germination
EX353_RS04025	COG4977	sequence-specific DNA binding
EX353_RS04050	COG2271	Major facilitator Superfamily
EX353_RS04055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EX353_RS04060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EX353_RS04070	COG3395	kinase activity
EX353_RS04075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EX353_RS04080	COG1349	DNA-binding transcription factor activity
EX353_RS04085	COG0039	L-malate dehydrogenase activity
EX353_RS04095	COG0583	DNA-binding transcription factor activity
EX353_RS04100	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS04115	COG2199	diguanylate cyclase activity
EX353_RS04195	COG0477	Major facilitator Superfamily
EX353_RS04205	COG2070	2-Nitropropane dioxygenase
EX353_RS04210	COG2011	ABC-type metal ion transport system permease component
EX353_RS04245	COG2207	Transcriptional regulator
EX353_RS04275	COG2233	PERMEase
EX353_RS04280	COG3195	allantoin biosynthetic process
EX353_RS04280	COG3648	Uricase
EX353_RS04285	COG2351	hydroxyisourate hydrolase activity
EX353_RS04290	COG1396	sequence-specific DNA binding
EX353_RS04295	COG3550	peptidyl-serine autophosphorylation
EX353_RS04300	COG1649	PFAM Uncharacterised BCR, COG1649
EX353_RS04315	COG3188	usher protein
EX353_RS04350	COG3300	MHYT domain
EX353_RS04350	COG5001	Diguanylate cyclase
EX353_RS04355	COG2819	hydrolase of the alpha beta superfamily
EX353_RS04365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS04365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS04370	COG2814	Major facilitator Superfamily
EX353_RS04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS04380	COG1263	PTS System
EX353_RS04385	COG2186	Transcriptional regulator
EX353_RS04405	COG3835	regulator
EX353_RS04410	COG1929	Belongs to the glycerate kinase type-1 family
EX353_RS04455	COG0738	Major facilitator superfamily
EX353_RS04460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EX353_RS04465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EX353_RS04470	COG1349	DNA-binding transcription factor activity
EX353_RS04495	COG0667	Aldo Keto reductase
EX353_RS04500	COG3386	PFAM SMP-30 Gluconolaconase
EX353_RS04505	COG0667	Aldo Keto reductase
EX353_RS04510	COG0667	Aldo Keto reductase
EX353_RS04520	COG0456	acetyltransferase
EX353_RS04520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EX353_RS04545	COG1652	LysM domain
EX353_RS04575	COG1609	Transcriptional regulator
EX353_RS04585	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS04610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EX353_RS04615	COG0583	DNA-binding transcription factor activity
EX353_RS04620	COG0583	DNA-binding transcription factor activity
EX353_RS04635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EX353_RS04640	COG3037	sugar-specific permease SgaT UlaA
EX353_RS04650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS04655	COG1609	Transcriptional regulator
EX353_RS04665	COG2223	nitrite transmembrane transporter activity
EX353_RS04695	COG0477	Major facilitator Superfamily
EX353_RS04700	COG4529	Protein conserved in bacteria
EX353_RS04705	COG1902	pentaerythritol trinitrate reductase activity
EX353_RS04715	COG0583	DNA-binding transcription factor activity
EX353_RS04720	COG2070	2-Nitropropane dioxygenase
EX353_RS04730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EX353_RS04740	COG0765	amino acid transport
EX353_RS04785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EX353_RS04810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EX353_RS04830	COG2207	Transcriptional regulator
EX353_RS04845	COG0596	Alpha beta hydrolase
EX353_RS04880	COG1953	Uracil, thiamine, allantoin
EX353_RS04885	COG0402	S-adenosylhomocysteine deaminase activity
EX353_RS04900	COG2135	peptidase activity
EX353_RS04905	COG2207	Transcriptional regulator
EX353_RS04920	COG4221	oxidoreductase activity
EX353_RS04925	COG1802	Transcriptional regulator
EX353_RS04930	COG0589	response to stress
EX353_RS04935	COG0246	Mannitol dehydrogenase
EX353_RS04940	COG2271	Major facilitator Superfamily
EX353_RS04955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EX353_RS04980	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EX353_RS04985	COG1940	carbohydrate kinase activity
EX353_RS04990	COG0583	DNA-binding transcription factor activity
EX353_RS04995	COG2814	Major facilitator Superfamily
EX353_RS05000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EX353_RS05010	COG3591	Belongs to the peptidase S1B family
EX353_RS05030	COG0628	permease
EX353_RS05060	COG0679	Auxin Efflux Carrier
EX353_RS05070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EX353_RS05095	COG3290	protein histidine kinase activity
EX353_RS05100	COG4565	transcriptional regulatory protein
EX353_RS05125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EX353_RS05125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EX353_RS05140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EX353_RS05145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EX353_RS05155	COG0183	Belongs to the thiolase family
EX353_RS05160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EX353_RS05170	COG1414	Transcriptional regulator
EX353_RS05175	COG2840	Smr protein MutS2
EX353_RS05180	COG0583	DNA-binding transcription factor activity
EX353_RS05190	COG1473	amidohydrolase
EX353_RS05195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EX353_RS05210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EX353_RS05225	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EX353_RS05230	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EX353_RS05250	COG0531	amino acid
EX353_RS05260	COG3136	membrane protein required for alginate biosynthesis
EX353_RS05265	COG0745	RESPONSE REGULATOR receiver
EX353_RS05275	COG2205	protein histidine kinase activity
EX353_RS05285	COG0114	fumarate hydratase activity
EX353_RS05290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EX353_RS05290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EX353_RS05295	COG1482	cell wall glycoprotein biosynthetic process
EX353_RS05300	COG5339	Protein conserved in bacteria
EX353_RS05305	COG1609	Transcriptional regulator
EX353_RS05310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS05310	COG1263	PTS System
EX353_RS05315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EX353_RS05340	COG2391	methyltransferase activity
EX353_RS05345	COG0425	Belongs to the sulfur carrier protein TusA family
EX353_RS05350	COG5562	phage envelope protein
EX353_RS05355	COG0401	homolog of Blt101
EX353_RS05360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EX353_RS05365	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS05370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EX353_RS05375	COG0477	Major facilitator Superfamily
EX353_RS05380	COG1113	amino acid transport
EX353_RS05385	COG2988	succinylglutamate desuccinylase activity
EX353_RS05390	COG3724	N-succinylarginine dihydrolase activity
EX353_RS05395	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS05400	COG3138	arginine N-succinyltransferase
EX353_RS05405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EX353_RS05410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EX353_RS05415	COG0667	Aldo Keto reductase
EX353_RS05420	COG0583	DNA-binding transcription factor activity
EX353_RS05445	COG4122	O-methyltransferase activity
EX353_RS05450	COG1643	Atp-dependent helicase
EX353_RS05465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EX353_RS05470	COG3327	negative regulation of DNA-templated transcription, initiation
EX353_RS05475	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EX353_RS05480	COG0183	Belongs to the thiolase family
EX353_RS05485	COG2050	protein possibly involved in aromatic compounds catabolism
EX353_RS05490	COG1250	3-hydroxyacyl-CoA dehydrogenase
EX353_RS05495	COG1024	Enoyl-CoA hydratase
EX353_RS05500	COG1024	Enoyl-CoA hydratase
EX353_RS05505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EX353_RS05510	COG2151	metal-sulfur cluster biosynthetic enzyme
EX353_RS05515	COG3396	Phenylacetate-CoA oxygenase
EX353_RS05520	COG3460	Phenylacetate-CoA oxygenase
EX353_RS05525	COG3396	Phenylacetate-CoA oxygenase
EX353_RS05530	COG2030	dehydratase
EX353_RS05530	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS05560	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS05565	COG2207	Transcriptional regulator
EX353_RS05570	COG3784	Protein of unknown function (DUF1318)
EX353_RS05580	COG2911	Protein conserved in bacteria
EX353_RS05585	COG0586	Pfam SNARE associated Golgi protein
EX353_RS05590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EX353_RS05595	COG3187	Heat shock protein
EX353_RS05600	COG3042	response to heat
EX353_RS05610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EX353_RS05610	COG1013	pyruvate-flavodoxin oxidoreductase activity
EX353_RS05610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EX353_RS05610	COG0674	pyruvate-flavodoxin oxidoreductase activity
EX353_RS05615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EX353_RS05625	COG0589	response to stress
EX353_RS05635	COG0513	Belongs to the DEAD box helicase family
EX353_RS05650	COG1349	DNA-binding transcription factor activity
EX353_RS05655	COG0673	inositol 2-dehydrogenase activity
EX353_RS05670	COG1113	amino acid transport
EX353_RS05675	COG1522	sequence-specific DNA binding
EX353_RS05685	COG1448	Aminotransferase
EX353_RS05690	COG2011	ABC-type metal ion transport system permease component
EX353_RS05705	COG0436	Aminotransferase
EX353_RS05710	COG0604	alcohol dehydrogenase
EX353_RS05735	COG0583	DNA-binding transcription factor activity
EX353_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS05760	COG1309	transcriptional regulator
EX353_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS05845	COG2885	chlorophyll binding
EX353_RS05870	COG0693	protein deglycase activity
EX353_RS05875	COG1078	dGTPase activity
EX353_RS05880	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS05885	COG0583	DNA-binding transcription factor activity
EX353_RS05955	COG0656	L-ascorbic acid biosynthetic process
EX353_RS06030	COG4166	transmembrane transport
EX353_RS06035	COG2866	Carboxypeptidase
EX353_RS06040	COG4948	Mandelate Racemase Muconate Lactonizing
EX353_RS06045	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EX353_RS06050	COG3180	Ammonia monooxygenase
EX353_RS06060	COG1486	melibiose metabolic process
EX353_RS06065	COG0583	DNA-binding transcription factor activity
EX353_RS06075	COG3106	COG3106 Predicted ATPase
EX353_RS06085	COG1983	PspC domain protein
EX353_RS06095	COG1842	Phage shock protein A
EX353_RS06100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EX353_RS06110	COG1473	amidohydrolase
EX353_RS06125	COG0702	epimerase
EX353_RS06140	COG4171	peptide transport system, permease
EX353_RS06155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EX353_RS06165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EX353_RS06170	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EX353_RS06170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EX353_RS06185	COG1349	DNA-binding transcription factor activity
EX353_RS06195	COG0023	Translation Initiation Factor
EX353_RS06205	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EX353_RS06210	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EX353_RS06215	COG0671	phosphoesterase, PA-phosphatase related
EX353_RS06225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EX353_RS06255	COG0616	signal peptide processing
EX353_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS06270	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EX353_RS06280	COG0583	DNA-binding transcription factor activity
EX353_RS06290	COG0009	L-threonylcarbamoyladenylate synthase
EX353_RS06300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EX353_RS06305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EX353_RS06305	COG0512	Glutamine amidotransferase of anthranilate synthase
EX353_RS06310	COG0135	phosphoribosylanthranilate isomerase activity
EX353_RS06310	COG0134	indole-3-glycerol-phosphate synthase activity
EX353_RS06365	COG4774	siderophore transport
EX353_RS06375	COG3047	cAMP biosynthetic process
EX353_RS06380	COG0727	PFAM Uncharacterised protein family (UPF0153)
EX353_RS06410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EX353_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS06420	COG1988	membrane-bound metal-dependent
EX353_RS06425	COG1823	symporter activity
EX353_RS06435	COG0753	catalase activity
EX353_RS06445	COG1486	melibiose metabolic process
EX353_RS06450	COG1917	Cupin 2, conserved barrel domain protein
EX353_RS06450	COG2169	Transcriptional regulator
EX353_RS06455	COG1447	Phosphotransferase system cellobiose-specific component IIA
EX353_RS06460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS06465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS06470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EX353_RS06480	COG0322	excinuclease ABC activity
EX353_RS06485	COG3678	ATP-independent chaperone mediated protein folding
EX353_RS06495	COG3724	N-succinylarginine dihydrolase activity
EX353_RS06505	COG3138	arginine N-succinyltransferase
EX353_RS06515	COG0708	Exodeoxyribonuclease III
EX353_RS06520	COG0398	Pfam SNARE associated Golgi protein
EX353_RS06525	COG0398	Pfam SNARE associated Golgi protein
EX353_RS06530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EX353_RS06535	COG4134	Bacterial extracellular solute-binding protein
EX353_RS06545	COG4136	ATPase activity
EX353_RS06550	COG2897	thiosulfate sulfurtransferase activity
EX353_RS06555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EX353_RS06560	COG0494	nUDIX hydrolase
EX353_RS06565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EX353_RS06570	COG0604	alcohol dehydrogenase
EX353_RS06570	COG3321	synthase
EX353_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS06575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EX353_RS06580	COG0709	Synthesizes selenophosphate from selenide and ATP
EX353_RS06600	COG0778	Nitroreductase
EX353_RS06605	COG0616	signal peptide processing
EX353_RS06610	COG0252	asparaginase activity
EX353_RS06615	COG1335	isochorismatase
EX353_RS06630	COG3139	Protein of unknown function (DUF1315)
EX353_RS06650	COG0656	L-ascorbic acid biosynthetic process
EX353_RS06655	COG3713	MltA-interacting MipA family protein
EX353_RS06660	COG2766	serine protein kinase
EX353_RS06675	COG0386	Belongs to the glutathione peroxidase family
EX353_RS06695	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS06700	COG0583	DNA-binding transcription factor activity
EX353_RS06705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EX353_RS06710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EX353_RS06735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EX353_RS06745	COG2207	Transcriptional regulator
EX353_RS06750	COG2807	transmembrane transport
EX353_RS06755	COG0504	CTP synthase activity
EX353_RS06760	COG1683	Conserved Protein
EX353_RS06765	COG3189	MarR family transcriptional regulator
EX353_RS06770	COG3042	response to heat
EX353_RS06775	COG2203	Gaf domain
EX353_RS06775	COG2199	diguanylate cyclase activity
EX353_RS06795	COG3182	Iron-regulated membrane protein
EX353_RS06805	COG1560	Kdo2-lipid A biosynthetic process
EX353_RS06820	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EX353_RS06825	COG3706	GGDEF domain
EX353_RS06830	COG0583	DNA-binding transcription factor activity
EX353_RS06835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EX353_RS06860	COG1294	oxidase, subunit
EX353_RS06865	COG1271	oxidase subunit
EX353_RS06870	COG3546	catalase activity
EX353_RS06875	COG3685	Protein conserved in bacteria
EX353_RS06880	COG3685	Protein conserved in bacteria
EX353_RS06885	COG3729	General stress protein
EX353_RS06890	COG1063	alcohol dehydrogenase
EX353_RS06895	COG3813	Protein conserved in bacteria
EX353_RS06915	COG0640	Transcriptional regulator
EX353_RS06920	COG0538	isocitrate dehydrogenase activity
EX353_RS06930	COG3300	MHYT domain
EX353_RS06930	COG5001	Diguanylate cyclase
EX353_RS06935	COG3706	GGDEF domain
EX353_RS07025	COG0616	signal peptide processing
EX353_RS07080	COG3772	lysozyme
EX353_RS07190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EX353_RS07200	COG0582	viral genome integration into host DNA
EX353_RS07205	COG0538	isocitrate dehydrogenase activity
EX353_RS07210	COG1187	pseudouridine synthase activity
EX353_RS07230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EX353_RS07250	COG2205	protein histidine kinase activity
EX353_RS07255	COG2850	peptidyl-arginine hydroxylation
EX353_RS07260	COG1943	Transposase
EX353_RS07285	COG1177	transmembrane transport
EX353_RS07300	COG0318	PFAM AMP-dependent synthetase and ligase
EX353_RS07305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EX353_RS07310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EX353_RS07315	COG0698	ribose 5-phosphate isomerase
EX353_RS07330	COG3395	kinase activity
EX353_RS07345	COG2390	Transcriptional regulator
EX353_RS07355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EX353_RS07365	COG4591	ABC-type transport system involved in lipoprotein release permease component
EX353_RS07375	COG4591	ABC-type transport system involved in lipoprotein release permease component
EX353_RS07380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EX353_RS07390	COG1309	transcriptional regulator
EX353_RS07400	COG3134	Outer membrane lipoprotein
EX353_RS07405	COG1252	NADH dehydrogenase
EX353_RS07430	COG5633	Lipoprotein
EX353_RS07435	COG0537	adenosine 5'-monophosphoramidase activity
EX353_RS07445	COG0084	hydrolase, TatD family'
EX353_RS07450	COG0470	DNA polymerase III
EX353_RS07460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EX353_RS07465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EX353_RS07470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EX353_RS07485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EX353_RS07505	COG1399	metal-binding, possibly nucleic acid-binding protein
EX353_RS07525	COG1530	ribonuclease E activity
EX353_RS07530	COG0583	DNA-binding transcription factor activity
EX353_RS07535	COG2814	Major facilitator Superfamily
EX353_RS07555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EX353_RS07605	COG1560	Kdo2-lipid A biosynthetic process
EX353_RS07625	COG5645	(Lipo)protein
EX353_RS07665	COG3381	protein complex oligomerization
EX353_RS07690	COG0583	DNA-binding transcription factor activity
EX353_RS07700	COG1335	isochorismatase
EX353_RS07710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EX353_RS07715	COG1702	phosphate starvation-inducible protein PhoH
EX353_RS07735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EX353_RS07745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EX353_RS07760	COG1309	transcriptional regulator
EX353_RS07795	COG2233	PERMEase
EX353_RS07805	COG3729	General stress protein
EX353_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS07845	COG0531	amino acid
EX353_RS07855	COG0174	glutamine synthetase
EX353_RS07860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EX353_RS07865	COG1917	Cupin 2, conserved barrel domain protein
EX353_RS07865	COG1396	sequence-specific DNA binding
EX353_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS07875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EX353_RS07880	COG0583	DNA-binding transcription factor activity
EX353_RS07885	COG0473	3-isopropylmalate dehydrogenase activity
EX353_RS07895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EX353_RS07900	COG4638	Rieske (2fe-2S)
EX353_RS07905	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS07910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EX353_RS07915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS07915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS07915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EX353_RS07920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EX353_RS07925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EX353_RS07930	COG1882	Formate acetyltransferase
EX353_RS07935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EX353_RS07940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EX353_RS07950	COG2207	Transcriptional regulator
EX353_RS07955	COG3706	GGDEF domain
EX353_RS07985	COG0058	SHG alpha-glucan phosphorylase activity
EX353_RS08000	COG0670	Belongs to the BI1 family
EX353_RS08015	COG2207	Transcriptional regulator
EX353_RS08020	COG1881	PFAM PEBP family protein
EX353_RS08035	COG1832	CoA-binding protein
EX353_RS08045	COG0210	DNA helicase
EX353_RS08050	COG3304	Inner membrane component domain
EX353_RS08055	COG1289	transmembrane transporter activity
EX353_RS08060	COG3070	regulator of competence-specific genes
EX353_RS08085	COG1067	ATP-dependent peptidase activity
EX353_RS08095	COG3130	regulation of translation
EX353_RS08100	COG3009	Protein conserved in bacteria
EX353_RS08105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EX353_RS08105	COG3008	intermembrane lipid transfer
EX353_RS08110	COG2995	paraquat-inducible protein a
EX353_RS08115	COG0488	(ABC) transporter
EX353_RS08125	COG3217	Mosc domain protein beta barrel domain protein
EX353_RS08125	COG0633	Ferredoxin
EX353_RS08140	COG0431	NADPH-dependent FMN reductase
EX353_RS08145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EX353_RS08150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EX353_RS08155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EX353_RS08165	COG0308	aminopeptidase N
EX353_RS08175	COG1473	amidohydrolase
EX353_RS08185	COG0814	amino acid
EX353_RS08195	COG1522	sequence-specific DNA binding
EX353_RS08205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EX353_RS08210	COG1448	Aminotransferase
EX353_RS08215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EX353_RS08220	COG3108	Peptidase M15
EX353_RS08225	COG2989	Protein conserved in bacteria
EX353_RS08235	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EX353_RS08245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EX353_RS08250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EX353_RS08255	COG3173	Aminoglycoside phosphotransferase
EX353_RS08270	COG3214	Protein conserved in bacteria
EX353_RS08285	COG0658	competence protein
EX353_RS08285	COG2333	competence protein COMEC
EX353_RS08295	COG0539	negative regulation of cytoplasmic translation
EX353_RS08315	COG2323	membrane
EX353_RS08320	COG1944	ATP diphosphatase activity
EX353_RS08325	COG2116	formate transmembrane transporter activity
EX353_RS08330	COG1882	Formate acetyltransferase
EX353_RS08335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EX353_RS08340	COG0477	Major facilitator Superfamily
EX353_RS08350	COG3302	dmso reductase anchor subunit
EX353_RS08355	COG0437	4 iron, 4 sulfur cluster binding
EX353_RS08360	COG0243	molybdopterin cofactor binding
EX353_RS08370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EX353_RS08380	COG1178	ABC-type Fe3 transport system permease component
EX353_RS08380	COG1674	ftsk spoiiie
EX353_RS08390	COG0492	ferredoxin-NADP+ reductase activity
EX353_RS08395	COG4988	ABC transporter
EX353_RS08400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EX353_RS08415	COG0542	response to heat
EX353_RS08425	COG1278	Cold shock
EX353_RS08435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS08440	COG3593	DNA synthesis involved in DNA repair
EX353_RS08450	COG2431	L-lysine efflux transmembrane transporter activity
EX353_RS08460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EX353_RS08470	COG0028	Belongs to the TPP enzyme family
EX353_RS08475	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EX353_RS08480	COG0702	epimerase
EX353_RS08485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EX353_RS08490	COG3023	N-Acetylmuramoyl-L-alanine amidase
EX353_RS08495	COG5001	Diguanylate cyclase
EX353_RS08495	COG4251	negative regulation of phosphorylation
EX353_RS08495	COG3706	GGDEF domain
EX353_RS08495	COG2203	Gaf domain
EX353_RS08510	COG1126	abc transporter atp-binding protein
EX353_RS08515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS08520	COG4215	(ABC) transporter
EX353_RS08525	COG4160	amino acid transport
EX353_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS08535	COG5002	protein histidine kinase activity
EX353_RS08540	COG0745	RESPONSE REGULATOR receiver
EX353_RS08555	COG1177	transmembrane transport
EX353_RS08560	COG1176	ABC-type spermidine putrescine transport system, permease component I
EX353_RS08565	COG3842	ATPase activity
EX353_RS08570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EX353_RS08585	COG0778	Nitroreductase
EX353_RS08610	COG3226	Transcriptional regulator
EX353_RS08615	COG0738	Major facilitator superfamily
EX353_RS08620	COG0561	phosphatase activity
EX353_RS08625	COG2814	Major facilitator Superfamily
EX353_RS08635	COG0671	phosphoesterase, PA-phosphatase related
EX353_RS08640	COG1349	DNA-binding transcription factor activity
EX353_RS08645	COG1686	Belongs to the peptidase S11 family
EX353_RS08650	COG0625	glutathione transferase activity
EX353_RS08655	COG2133	pyrroloquinoline quinone binding
EX353_RS08665	COG2223	nitrite transmembrane transporter activity
EX353_RS08685	COG0747	negative chemotaxis
EX353_RS08700	COG0303	'Molybdopterin
EX353_RS08705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EX353_RS08710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EX353_RS08715	COG1882	Formate acetyltransferase
EX353_RS08720	COG0561	phosphatase activity
EX353_RS08730	COG1609	Transcriptional regulator
EX353_RS08735	COG2271	Major facilitator Superfamily
EX353_RS08745	COG0488	(ABC) transporter
EX353_RS08750	COG2365	Tyrosine phosphatase family
EX353_RS08755	COG1376	ErfK ybiS ycfS ynhG family protein
EX353_RS08760	COG2188	Transcriptional regulator
EX353_RS08765	COG2723	6-phospho-beta-galactosidase activity
EX353_RS08775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EX353_RS08790	COG2194	sulfuric ester hydrolase activity
EX353_RS08795	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EX353_RS08810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS08815	COG0765	amino acid transport
EX353_RS08820	COG1126	abc transporter atp-binding protein
EX353_RS08825	COG0668	transmembrane transport
EX353_RS08835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EX353_RS08845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EX353_RS08855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EX353_RS08860	COG1199	ATP-dependent helicase activity
EX353_RS08865	COG0513	Belongs to the DEAD box helicase family
EX353_RS08870	COG3958	Transketolase
EX353_RS08875	COG3959	Transketolase, thiamine diphosphate binding domain
EX353_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS08885	COG2271	Major facilitator Superfamily
EX353_RS08890	COG0583	DNA-binding transcription factor activity
EX353_RS08895	COG1309	transcriptional regulator
EX353_RS08900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS08905	COG1131	(ABC) transporter
EX353_RS08910	COG0842	Transport permease protein
EX353_RS08915	COG0842	Transport permease protein
EX353_RS08925	COG3568	Endonuclease Exonuclease Phosphatase
EX353_RS08930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EX353_RS08935	COG0392	lysyltransferase activity
EX353_RS08940	COG0670	Belongs to the BI1 family
EX353_RS08945	COG0314	molybdopterin synthase activity
EX353_RS08950	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EX353_RS08960	COG0521	Mo-molybdopterin cofactor biosynthetic process
EX353_RS08985	COG0745	RESPONSE REGULATOR receiver
EX353_RS08990	COG0642	Histidine kinase
EX353_RS09030	COG2226	methyltransferase
EX353_RS09045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EX353_RS09050	COG1881	PFAM PEBP family protein
EX353_RS09090	COG4677	pectinesterase activity
EX353_RS09100	COG0589	response to stress
EX353_RS09105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS09135	COG0789	Transcriptional regulator
EX353_RS09140	COG2200	EAL domain
EX353_RS09165	COG0561	phosphatase activity
EX353_RS09170	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EX353_RS09175	COG4149	molybdate abc transporter
EX353_RS09180	COG0725	ABC transporter, periplasmic molybdate-binding protein
EX353_RS09190	COG3585	molybdate ion transport
EX353_RS09190	COG2005	Transcriptional regulator
EX353_RS09195	COG1119	ATPase activity
EX353_RS09205	COG1085	galactose-1-phosphate uridylyltransferase
EX353_RS09215	COG2017	converts alpha-aldose to the beta-anomer
EX353_RS09225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EX353_RS09240	COG3201	nicotinamide mononucleotide transporter
EX353_RS09245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EX353_RS09285	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EX353_RS09290	COG2885	chlorophyll binding
EX353_RS09300	COG3064	Membrane
EX353_RS09305	COG0848	biopolymer transport protein
EX353_RS09310	COG0811	peptide transport
EX353_RS09315	COG0824	Thioesterase
EX353_RS09320	COG3790	cyd operon protein YbgE
EX353_RS09325	COG4890	Cyd operon protein YbgT
EX353_RS09330	COG1294	oxidase, subunit
EX353_RS09335	COG1271	oxidase subunit
EX353_RS09345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EX353_RS09360	COG0508	dehydrogenase complex catalyzes the overall conversion of
EX353_RS09365	COG0567	Dehydrogenase, E1 component
EX353_RS09370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EX353_RS09375	COG1053	succinate dehydrogenase
EX353_RS09380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EX353_RS09385	COG2009	succinate dehydrogenase
EX353_RS09420	COG1984	allophanate hydrolase subunit 2
EX353_RS09425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EX353_RS09440	COG0415	Belongs to the DNA photolyase family
EX353_RS09470	COG2205	protein histidine kinase activity
EX353_RS09475	COG0745	RESPONSE REGULATOR receiver
EX353_RS09485	COG0033	Phosphoglucomutase
EX353_RS09495	COG0596	Alpha beta hydrolase
EX353_RS09510	COG0735	belongs to the Fur family
EX353_RS09550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EX353_RS09555	COG1940	carbohydrate kinase activity
EX353_RS09555	COG1846	Transcriptional regulator
EX353_RS09560	COG0647	UMP catabolic process
EX353_RS09565	COG0367	asparagine synthase
EX353_RS09610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EX353_RS09620	COG1702	phosphate starvation-inducible protein PhoH
EX353_RS09645	COG0765	amino acid transport
EX353_RS09650	COG0765	amino acid transport
EX353_RS09655	COG1126	abc transporter atp-binding protein
EX353_RS09670	COG2888	peptidyl-tyrosine sulfation
EX353_RS09685	COG1466	dna polymerase III delta subunit
EX353_RS09700	COG0799	negative regulation of ribosome biogenesis
EX353_RS09710	COG0768	penicillin binding
EX353_RS09715	COG0772	Belongs to the SEDS family
EX353_RS09720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EX353_RS09725	COG1686	Belongs to the peptidase S11 family
EX353_RS09740	COG0583	DNA-binding transcription factor activity
EX353_RS09755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EX353_RS09780	COG3069	C4-dicarboxylate transmembrane transporter activity
EX353_RS09785	COG3719	Belongs to the RNase T2 family
EX353_RS09790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EX353_RS09810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EX353_RS09815	COG0583	DNA-binding transcription factor activity
EX353_RS09820	COG3969	phosphoadenosine phosphosulfate
EX353_RS09825	COG1475	DNA binding
EX353_RS09830	COG0436	Aminotransferase
EX353_RS09855	COG1129	ABC transporter
EX353_RS09860	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS09865	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS09875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EX353_RS09890	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EX353_RS09900	COG0402	S-adenosylhomocysteine deaminase activity
EX353_RS09910	COG0483	inositol monophosphate 1-phosphatase activity
EX353_RS09915	COG2271	Major facilitator Superfamily
EX353_RS09945	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS09950	COG1129	ABC transporter
EX353_RS09955	COG0371	Dehydrogenase
EX353_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS09975	COG2879	small protein
EX353_RS09980	COG1966	Carbon starvation protein
EX353_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS09995	COG3433	isochorismatase activity
EX353_RS09995	COG1535	isochorismatase
EX353_RS10000	COG1021	2,3-dihydroxybenzoate-AMP ligase
EX353_RS10005	COG1169	isochorismate synthase
EX353_RS10010	COG4592	Periplasmic binding protein
EX353_RS10020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS10025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS10030	COG1120	ATPase activity
EX353_RS10035	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EX353_RS10035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EX353_RS10040	COG3251	PFAM MbtH domain protein
EX353_RS10045	COG2382	esterase
EX353_RS10055	COG4771	TonB-dependent receptor
EX353_RS10060	COG2977	Belongs to the P-Pant transferase superfamily
EX353_RS10065	COG3958	Transketolase
EX353_RS10070	COG3959	Transketolase, thiamine diphosphate binding domain
EX353_RS10080	COG2390	Transcriptional regulator
EX353_RS10085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EX353_RS10100	COG1129	ABC transporter
EX353_RS10105	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS10125	COG0583	DNA-binding transcription factor activity
EX353_RS10130	COG0668	transmembrane transport
EX353_RS10140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EX353_RS10165	COG0747	negative chemotaxis
EX353_RS10170	COG0601	transmembrane transport
EX353_RS10175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS10180	COG0444	Belongs to the ABC transporter superfamily
EX353_RS10185	COG4608	Belongs to the ABC transporter superfamily
EX353_RS10200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EX353_RS10205	COG4221	oxidoreductase activity
EX353_RS10215	COG4215	(ABC) transporter
EX353_RS10225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EX353_RS10240	COG0697	spore germination
EX353_RS10255	COG4608	Belongs to the ABC transporter superfamily
EX353_RS10260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS10280	COG3698	Phosphodiester glycosidase
EX353_RS10325	COG3344	reverse transcriptase
EX353_RS10335	COG2315	Protein conserved in bacteria
EX353_RS10340	COG0778	Nitroreductase
EX353_RS10350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS10360	COG3716	PTS system mannose fructose sorbose family IID component
EX353_RS10365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EX353_RS10370	COG2222	sugar isomerase
EX353_RS10375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EX353_RS10375	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EX353_RS10395	COG0477	Major facilitator Superfamily
EX353_RS10400	COG0668	transmembrane transport
EX353_RS10405	COG1609	Transcriptional regulator
EX353_RS10415	COG0673	inositol 2-dehydrogenase activity
EX353_RS10425	COG2211	Major facilitator Superfamily
EX353_RS10430	COG1113	amino acid transport
EX353_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS10450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EX353_RS10460	COG0531	amino acid
EX353_RS10515	COG0667	Aldo Keto reductase
EX353_RS10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS10525	COG1473	amidohydrolase
EX353_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS10550	COG1120	ATPase activity
EX353_RS10555	COG1566	PFAM secretion protein HlyD family protein
EX353_RS10600	COG4211	Belongs to the binding-protein-dependent transport system permease family
EX353_RS10605	COG1129	ABC transporter
EX353_RS10620	COG0673	inositol 2-dehydrogenase activity
EX353_RS10650	COG3104	oligopeptide transport
EX353_RS10655	COG1982	Orn Lys Arg decarboxylase major
EX353_RS10660	COG0531	amino acid
EX353_RS10670	COG3710	Transcriptional regulator
EX353_RS10685	COG1560	Kdo2-lipid A biosynthetic process
EX353_RS10700	COG3188	usher protein
EX353_RS10705	COG3121	Chaperone
EX353_RS10710	COG3539	Fimbrial protein
EX353_RS10765	COG2501	S4 domain
EX353_RS10770	COG1988	membrane-bound metal-dependent
EX353_RS10790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EX353_RS10805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EX353_RS10810	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EX353_RS10815	COG0549	Belongs to the carbamate kinase family
EX353_RS10825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EX353_RS10830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EX353_RS10835	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EX353_RS10840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EX353_RS10845	COG3257	ureidoglycine aminohydrolase activity
EX353_RS10850	COG1929	Belongs to the glycerate kinase type-1 family
EX353_RS10855	COG2233	PERMEase
EX353_RS10865	COG1953	Uracil, thiamine, allantoin
EX353_RS10880	COG3622	Belongs to the hyi family
EX353_RS10885	COG3960	tartronate-semialdehyde synthase activity
EX353_RS10920	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EX353_RS10925	COG4181	ATPase activity
EX353_RS10930	COG2755	lipolytic protein G-D-S-L family
EX353_RS10935	COG0300	oxidoreductase activity
EX353_RS10940	COG3118	belongs to the thioredoxin family
EX353_RS10950	COG0390	transport system, permease component
EX353_RS10955	COG4619	ABC transporter
EX353_RS10960	COG0330	HflC and HflK could
EX353_RS10965	COG1585	Membrane protein implicated in regulation of membrane protease activity
EX353_RS10980	COG3735	TraB family
EX353_RS10985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EX353_RS10995	COG2223	nitrite transmembrane transporter activity
EX353_RS11000	COG4651	solute:proton antiporter activity
EX353_RS11000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EX353_RS11005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EX353_RS11045	COG2832	Protein of unknown function (DUF454)
EX353_RS11050	COG3923	Primosomal replication protein n
EX353_RS11065	COG1196	nuclear chromosome segregation
EX353_RS11065	COG3264	Mechanosensitive ion channel
EX353_RS11070	COG1309	transcriptional regulator
EX353_RS11075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS11080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EX353_RS11095	COG0110	maltose O-acetyltransferase activity
EX353_RS11140	COG1874	Beta-galactosidase
EX353_RS11145	COG3867	Arabinogalactan endo-beta-1,4-galactanase
EX353_RS11150	COG3833	ABC-type maltose transport systems, permease component
EX353_RS11155	COG1175	transmembrane transport
EX353_RS11160	COG2182	Extracellular solute-binding protein
EX353_RS11170	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EX353_RS11185	COG2364	Membrane
EX353_RS11215	COG3695	enzyme binding
EX353_RS11220	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EX353_RS11225	COG1946	Acyl-CoA thioesterase
EX353_RS11230	COG0004	ammonium transporteR
EX353_RS11235	COG0347	Belongs to the P(II) protein family
EX353_RS11240	COG1132	(ABC) transporter
EX353_RS11245	COG1132	(ABC) transporter
EX353_RS11250	COG1522	sequence-specific DNA binding
EX353_RS11265	COG4533	DNA binding
EX353_RS11275	COG0824	Thioesterase
EX353_RS11280	COG1555	photosystem II stabilization
EX353_RS11285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EX353_RS11290	COG0776	regulation of translation
EX353_RS11295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EX353_RS11325	COG0271	Belongs to the BolA IbaG family
EX353_RS11330	COG3056	Lipoprotein
EX353_RS11335	COG2223	nitrite transmembrane transporter activity
EX353_RS11340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EX353_RS11345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EX353_RS11350	COG1845	cytochrome c oxidase, subunit III
EX353_RS11355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EX353_RS11370	COG1414	Transcriptional regulator
EX353_RS11375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EX353_RS11380	COG1053	succinate dehydrogenase
EX353_RS11390	COG1053	succinate dehydrogenase
EX353_RS11405	COG0673	inositol 2-dehydrogenase activity
EX353_RS11410	COG2814	Major facilitator Superfamily
EX353_RS11420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EX353_RS11425	COG0693	protein deglycase activity
EX353_RS11445	COG0142	geranyltranstransferase activity
EX353_RS11455	COG0667	Aldo Keto reductase
EX353_RS11460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EX353_RS11480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EX353_RS11480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EX353_RS11490	COG4238	major outer membrane lipoprotein
EX353_RS11510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EX353_RS11515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EX353_RS11520	COG1862	Preprotein translocase
EX353_RS11540	COG0450	alkyl hydroperoxide reductase
EX353_RS11545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS11560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EX353_RS11570	COG1228	amidohydrolase
EX353_RS11580	COG1335	isochorismatase
EX353_RS11585	COG0583	DNA-binding transcription factor activity
EX353_RS11590	COG0366	Alpha amylase catalytic
EX353_RS11615	COG0420	3'-5' exonuclease activity
EX353_RS11620	COG0419	ATPase involved in DNA repair
EX353_RS11625	COG1940	carbohydrate kinase activity
EX353_RS11640	COG4126	flavin adenine dinucleotide binding
EX353_RS11650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EX353_RS11655	COG3416	Protein conserved in bacteria
EX353_RS11665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EX353_RS11675	COG1785	Belongs to the alkaline phosphatase family
EX353_RS11715	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EX353_RS11720	COG1335	isochorismatase
EX353_RS11725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EX353_RS11730	COG0113	porphobilinogen synthase activity
EX353_RS11740	COG2175	clavaminate synthase activity
EX353_RS11745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EX353_RS11750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EX353_RS11755	COG4521	taurine ABC transporter
EX353_RS11760	COG2040	homocysteine
EX353_RS11765	COG0833	amino acid
EX353_RS11775	COG4303	Ethanolamine ammonia lyase large subunit
EX353_RS11780	COG4302	ethanolamine ammonia-lyase activity
EX353_RS11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS11825	COG1126	abc transporter atp-binding protein
EX353_RS11830	COG4597	amino acid ABC transporter
EX353_RS11835	COG0765	amino acid transport
EX353_RS11850	COG3188	usher protein
EX353_RS11875	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EX353_RS11885	COG3639	organic phosphonate transmembrane transporter activity
EX353_RS11915	COG0791	NLP P60 protein
EX353_RS11975	COG2909	trisaccharide binding
EX353_RS11980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EX353_RS11985	COG0022	dehydrogenase e1 component
EX353_RS11990	COG0508	dehydrogenase complex catalyzes the overall conversion of
EX353_RS11995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EX353_RS12020	COG1070	Carbohydrate kinase
EX353_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS12030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EX353_RS12035	COG3775	system Galactitol-specific IIC component
EX353_RS12040	COG0625	glutathione transferase activity
EX353_RS12045	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EX353_RS12065	COG0579	oxidoreductase
EX353_RS12070	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS12075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EX353_RS12080	COG1113	amino acid transport
EX353_RS12085	COG1802	Transcriptional regulator
EX353_RS12105	COG2195	Cleaves the N-terminal amino acid of tripeptides
EX353_RS12110	COG0454	-acetyltransferase
EX353_RS12125	COG2991	Protein conserved in bacteria
EX353_RS12140	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EX353_RS12145	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EX353_RS12165	COG3034	peptidoglycan biosynthetic process
EX353_RS12170	COG0121	glutamine amidotransferase
EX353_RS12180	COG1960	acyl-CoA dehydrogenase activity
EX353_RS12185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EX353_RS12195	COG0583	DNA-binding transcription factor activity
EX353_RS12205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EX353_RS12215	COG2226	methyltransferase
EX353_RS12225	COG0741	lytic transglycosylase activity
EX353_RS12225	COG1388	LysM domain
EX353_RS12230	COG2226	methyltransferase
EX353_RS12240	COG2814	Major facilitator Superfamily
EX353_RS12245	COG0583	DNA-binding transcription factor activity
EX353_RS12250	COG0656	L-ascorbic acid biosynthetic process
EX353_RS12285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EX353_RS12295	COG2011	ABC-type metal ion transport system permease component
EX353_RS12300	COG1464	Belongs to the NlpA lipoprotein family
EX353_RS12310	COG1720	tRNA m6t6A37 methyltransferase activity
EX353_RS12320	COG0791	NLP P60 protein
EX353_RS12325	COG3015	lipoprotein NlpE involved in copper resistance
EX353_RS12330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EX353_RS12345	COG4568	rho-dependent transcription termination
EX353_RS12355	COG0346	lactoylglutathione lyase activity
EX353_RS12370	COG0587	DNA-directed DNA polymerase activity
EX353_RS12400	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EX353_RS12410	COG0750	zinc metalloprotease
EX353_RS12415	COG0575	Belongs to the CDS family
EX353_RS12430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EX353_RS12455	COG0024	Methionine aminopeptidase
EX353_RS12460	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EX353_RS12475	COG3835	regulator
EX353_RS12480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EX353_RS12500	COG2860	membrane
EX353_RS12520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS12525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EX353_RS12530	COG1120	ATPase activity
EX353_RS12535	COG4774	siderophore transport
EX353_RS12540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EX353_RS12625	COG1643	Atp-dependent helicase
EX353_RS12630	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EX353_RS12650	COG0617	tRNA 3'-terminal CCA addition
EX353_RS12655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EX353_RS12680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS12685	COG0842	Transport permease protein
EX353_RS12690	COG1131	(ABC) transporter
EX353_RS12695	COG0288	reversible hydration of carbon dioxide
EX353_RS12705	COG4993	Dehydrogenase
EX353_RS12710	COG2132	Multicopper oxidase
EX353_RS12755	COG3064	Membrane
EX353_RS12770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EX353_RS12775	COG0508	dehydrogenase complex catalyzes the overall conversion of
EX353_RS12780	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EX353_RS12785	COG2186	Transcriptional regulator
EX353_RS12790	COG1113	amino acid transport
EX353_RS12795	COG2211	Major facilitator Superfamily
EX353_RS12800	COG3940	Belongs to the glycosyl hydrolase 43 family
EX353_RS12810	COG3023	N-Acetylmuramoyl-L-alanine amidase
EX353_RS12820	COG4969	Belongs to the N-Me-Phe pilin family
EX353_RS12825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EX353_RS12830	COG1459	type II secretion system
EX353_RS12855	COG0494	nUDIX hydrolase
EX353_RS12875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EX353_RS12880	COG0849	cell division
EX353_RS12905	COG0772	Belongs to the SEDS family
EX353_RS12920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EX353_RS12925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EX353_RS12930	COG0768	penicillin binding
EX353_RS12960	COG1609	Transcriptional regulator
EX353_RS12970	COG0028	Belongs to the TPP enzyme family
EX353_RS13020	COG0738	Major facilitator superfamily
EX353_RS13030	COG0583	DNA-binding transcription factor activity
EX353_RS13040	COG2814	Major facilitator Superfamily
EX353_RS13065	COG1178	ABC-type Fe3 transport system permease component
EX353_RS13075	COG0586	Pfam SNARE associated Golgi protein
EX353_RS13095	COG0235	Class ii aldolase
EX353_RS13100	COG0417	DNA replication proofreading
EX353_RS13110	COG0564	pseudouridine synthase activity
EX353_RS13125	COG3493	citrate carrier protein
EX353_RS13140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EX353_RS13145	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EX353_RS13155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EX353_RS13205	COG0505	Belongs to the CarA family
EX353_RS13215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EX353_RS13240	COG1047	Peptidyl-prolyl cis-trans
EX353_RS13255	COG0196	riboflavin kinase activity
EX353_RS13270	COG0583	DNA-binding transcription factor activity
EX353_RS13295	COG4735	regulation of single-species biofilm formation
EX353_RS13300	COG1584	GPR1 FUN34 yaaH family protein
EX353_RS13305	COG0477	Major facilitator Superfamily
EX353_RS13310	COG0521	Mo-molybdopterin cofactor biosynthetic process
EX353_RS13315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EX353_RS13320	COG1115	amino acid carrier protein
EX353_RS13335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EX353_RS13345	COG0460	homoserine dehydrogenase
EX353_RS13345	COG0527	aspartate kinase activity
EX353_RS13355	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EX353_RS13365	COG0745	RESPONSE REGULATOR receiver
EX353_RS13370	COG4452	Inner membrane protein CreD
EX353_RS13375	COG2205	protein histidine kinase activity
EX353_RS13380	COG0745	RESPONSE REGULATOR receiver
EX353_RS13385	COG3045	CreA protein
EX353_RS13390	COG2207	Transcriptional regulator
EX353_RS13390	COG3708	Transcriptional regulator
EX353_RS13410	COG0741	lytic transglycosylase activity
EX353_RS13415	COG0488	(ABC) transporter
EX353_RS13425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EX353_RS13430	COG0560	Phosphoserine phosphatase
EX353_RS13440	COG3726	membrane protein affecting hemolysin expression
EX353_RS13470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EX353_RS13475	COG0084	hydrolase, TatD family'
EX353_RS13480	COG4667	esterase of the alpha-beta hydrolase superfamily
EX353_RS13490	COG2823	Periplasmic or secreted lipoprotein
EX353_RS13500	COG1011	Hydrolase
EX353_RS13505	COG0456	acetyltransferase
EX353_RS13510	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
EX353_RS13540	COG3706	GGDEF domain
EX353_RS13545	COG4114	ferric iron reductase
EX353_RS13550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS13550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS13555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EX353_RS13560	COG2197	response regulator
EX353_RS13565	COG2197	response regulator
EX353_RS13585	COG2966	Psort location CytoplasmicMembrane, score
EX353_RS13600	COG1484	DNA-dependent DNA replication
EX353_RS13615	COG5464	transposase or invertase
EX353_RS13625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EX353_RS13630	COG3716	PTS system mannose fructose sorbose family IID component
EX353_RS13635	COG3715	PTS system
EX353_RS13650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EX353_RS13650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EX353_RS13655	COG0456	acetyltransferase
EX353_RS13655	COG1214	PFAM Peptidase M22, glycoprotease
EX353_RS13665	COG1737	Transcriptional regulator
EX353_RS13670	COG0800	Aldolase
EX353_RS13675	COG3734	2-keto-3-deoxy-galactonokinase
EX353_RS13690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EX353_RS13715	COG1846	Transcriptional regulator
EX353_RS13720	COG0179	Fumarylacetoacetate (FAA) hydrolase
EX353_RS13730	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS13735	COG3384	dioxygenase
EX353_RS13745	COG3971	2-oxopent-4-enoate hydratase activity
EX353_RS13765	COG2368	4-hydroxyphenylacetate
EX353_RS13770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EX353_RS13785	COG1966	Carbon starvation protein
EX353_RS13790	COG2879	small protein
EX353_RS13795	COG0523	cobalamin synthesis protein
EX353_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS13810	COG5464	transposase or invertase
EX353_RS13815	COG1917	Cupin 2, conserved barrel domain protein
EX353_RS13815	COG2207	Transcriptional regulator
EX353_RS13825	COG2733	membrane
EX353_RS13840	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
EX353_RS13845	COG1924	4 iron, 4 sulfur cluster binding
EX353_RS13860	COG1566	PFAM secretion protein HlyD family protein
EX353_RS13870	COG5457	Domain of unknown function (DUF1127)
EX353_RS13875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EX353_RS13885	COG0583	DNA-binding transcription factor activity
EX353_RS13890	COG2249	NAD(P)H dehydrogenase (quinone) activity
EX353_RS13900	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS13905	COG1129	ABC transporter
EX353_RS13910	COG1879	ABC-type sugar transport system periplasmic component
EX353_RS13920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS13925	COG1129	ABC transporter
EX353_RS13925	COG0842	Transport permease protein
EX353_RS13930	COG0842	Transport permease protein
EX353_RS13960	COG2850	peptidyl-arginine hydroxylation
EX353_RS13975	COG5002	protein histidine kinase activity
EX353_RS13980	COG0745	RESPONSE REGULATOR receiver
EX353_RS13990	COG1538	Outer membrane efflux protein
EX353_RS13995	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS14000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS14005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EX353_RS14015	COG3040	lipid binding
EX353_RS14020	COG0789	Transcriptional regulator
EX353_RS14025	COG3631	Ketosteroid isomerase-related protein
EX353_RS14030	COG0300	oxidoreductase activity
EX353_RS14045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EX353_RS14065	COG3272	Protein of unknown function (DUF1722)
EX353_RS14070	COG4580	involved in the transport of maltose and maltodextrins
EX353_RS14075	COG2115	Belongs to the xylose isomerase family
EX353_RS14085	COG3507	Belongs to the glycosyl hydrolase 43 family
EX353_RS14105	COG1216	Glycosyl transferase, family 2
EX353_RS14235	COG0071	Belongs to the small heat shock protein (HSP20) family
EX353_RS14350	COG3423	Transcriptional regulator
EX353_RS14365	COG3732	PTS system glucitol sorbitol-specific
EX353_RS14370	COG0673	inositol 2-dehydrogenase activity
EX353_RS14390	COG3121	Chaperone
EX353_RS14400	COG0582	viral genome integration into host DNA
EX353_RS14490	COG0582	viral genome integration into host DNA
EX353_RS14505	COG0288	reversible hydration of carbon dioxide
EX353_RS14510	COG0659	secondary active sulfate transmembrane transporter activity
EX353_RS14515	COG1064	alcohol dehydrogenase
EX353_RS14520	COG1175	transmembrane transport
EX353_RS14525	COG0395	ABC-type sugar transport system, permease component
EX353_RS14530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EX353_RS14535	COG3842	ATPase activity
EX353_RS14550	COG1082	Xylose isomerase domain protein TIM barrel
EX353_RS14560	COG3962	Belongs to the TPP enzyme family
EX353_RS14565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EX353_RS14570	COG0837	glucose binding
EX353_RS14570	COG1737	Transcriptional regulator
EX353_RS14585	COG3718	enzyme involved in inositol metabolism
EX353_RS14600	COG0433	COG0433 Predicted ATPase
EX353_RS14605	COG0795	lipopolysaccharide-transporting ATPase activity
EX353_RS14610	COG0795	lipopolysaccharide-transporting ATPase activity
EX353_RS14625	COG2927	DNA polymerase III (CHI subunit)
EX353_RS14630	COG0525	valine-tRNA ligase activity
EX353_RS14655	COG2731	YhcH YjgK YiaL family protein
EX353_RS14700	COG1263	PTS System
EX353_RS14700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS14705	COG0366	Alpha amylase catalytic
EX353_RS14710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS14715	COG1486	melibiose metabolic process
EX353_RS14735	COG0602	queuosine metabolic process
EX353_RS14740	COG2026	Addiction module toxin, RelE StbE family
EX353_RS14745	COG3077	Addiction module antitoxin, RelB DinJ family
EX353_RS14750	COG3711	transcriptional antiterminator
EX353_RS14750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS14755	COG2706	6-phosphogluconolactonase activity
EX353_RS14770	COG3964	amidohydrolase
EX353_RS14805	COG0312	modulator of DNA gyrase
EX353_RS14825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EX353_RS14835	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS14840	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS14845	COG1129	ABC transporter
EX353_RS14850	COG1879	ABC-type sugar transport system periplasmic component
EX353_RS14865	COG2105	PFAM AIG2 family protein
EX353_RS14870	COG2911	Protein conserved in bacteria
EX353_RS14875	COG0729	surface antigen
EX353_RS14885	COG1253	flavin adenine dinucleotide binding
EX353_RS14900	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EX353_RS14915	COG1733	regulation of RNA biosynthetic process
EX353_RS14920	COG0702	epimerase
EX353_RS14930	COG0697	spore germination
EX353_RS14940	COG1113	amino acid transport
EX353_RS14945	COG0545	Peptidyl-prolyl cis-trans isomerase
EX353_RS14950	COG3061	Opacity-associated protein A
EX353_RS14960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EX353_RS14965	COG2965	DNA replication, synthesis of RNA primer
EX353_RS15025	COG1073	alpha beta
EX353_RS15030	COG3650	response to hydrogen peroxide
EX353_RS15040	COG1960	acyl-CoA dehydrogenase activity
EX353_RS15045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EX353_RS15050	COG0557	exoribonuclease II activity
EX353_RS15065	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EX353_RS15075	COG0330	HflC and HflK could
EX353_RS15080	COG0330	HflC and HflK could
EX353_RS15085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EX353_RS15105	COG0860	N-Acetylmuramoyl-L-alanine amidase
EX353_RS15110	COG0802	atpase or kinase
EX353_RS15115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EX353_RS15115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EX353_RS15120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EX353_RS15145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS15170	COG3264	Mechanosensitive ion channel
EX353_RS15170	COG1511	domain protein
EX353_RS15185	COG1053	succinate dehydrogenase
EX353_RS15190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EX353_RS15210	COG2076	Multidrug Resistance protein
EX353_RS15215	COG5510	response to toxic substance
EX353_RS15230	COG1509	lysine 2,3-aminomutase activity
EX353_RS15305	COG0531	amino acid
EX353_RS15310	COG3030	protein affecting phage T7 exclusion by the F plasmid
EX353_RS15320	COG1027	Aspartate ammonia-lyase
EX353_RS15325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EX353_RS15340	COG1309	transcriptional regulator
EX353_RS15370	COG0457	Tetratricopeptide repeat
EX353_RS15375	COG1649	PFAM Uncharacterised BCR, COG1649
EX353_RS15375	COG0726	polysaccharide deacetylase
EX353_RS15380	COG1215	transferase activity, transferring glycosyl groups
EX353_RS15400	COG0861	Integral membrane protein TerC family
EX353_RS15435	COG1486	melibiose metabolic process
EX353_RS15445	COG2169	Transcriptional regulator
EX353_RS15460	COG2824	Alkylphosphonate utilization operon protein PhnA
EX353_RS15465	COG2764	glyoxalase bleomycin resistance protein dioxygenase
EX353_RS15470	COG2188	Transcriptional regulator
EX353_RS15475	COG3624	Phosphonate C-P lyase system protein PhnG
EX353_RS15480	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EX353_RS15485	COG3626	phosphonate metabolism
EX353_RS15490	COG3627	carbon phosphorus lyase activity
EX353_RS15495	COG4107	phosphonate C-P lyase system protein PhnK
EX353_RS15500	COG4778	phosphonate C-P lyase system protein PhnL
EX353_RS15505	COG3454	Phosphonate metabolism
EX353_RS15515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EX353_RS15525	COG4191	Histidine kinase
EX353_RS15525	COG0784	Response regulator, receiver
EX353_RS15530	COG1129	ABC transporter
EX353_RS15535	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS15560	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EX353_RS15565	COG1301	dicarboxylic acid transport
EX353_RS15575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EX353_RS15585	COG3162	membrane
EX353_RS15615	COG3539	Fimbrial protein
EX353_RS15620	COG1346	cytolysis
EX353_RS15625	COG1380	Effector of murein hydrolase LrgA
EX353_RS15630	COG0583	DNA-binding transcription factor activity
EX353_RS15635	COG0025	NhaP-type Na H and K H
EX353_RS15640	COG2252	PERMEase
EX353_RS15645	COG0625	glutathione transferase activity
EX353_RS15650	COG0789	Transcriptional regulator
EX353_RS15660	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EX353_RS15695	COG1234	tRNA 3'-trailer cleavage
EX353_RS15700	COG1609	Transcriptional regulator
EX353_RS15705	COG0483	inositol monophosphate 1-phosphatase activity
EX353_RS15720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EX353_RS15740	COG4771	TonB-dependent receptor
EX353_RS15745	COG0741	lytic transglycosylase activity
EX353_RS15765	COG2315	Protein conserved in bacteria
EX353_RS15770	COG0432	Pfam Uncharacterised protein family UPF0047
EX353_RS15785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EX353_RS15790	COG0305	Participates in initiation and elongation during chromosome replication
EX353_RS15805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EX353_RS15815	COG0735	belongs to the Fur family
EX353_RS15820	COG3237	CsbD-like
EX353_RS15825	COG0534	Mate efflux family protein
EX353_RS15835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EX353_RS15910	COG0251	oxidation-reduction process
EX353_RS15920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EX353_RS15940	COG0527	aspartate kinase activity
EX353_RS15990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EX353_RS16000	COG0456	acetyltransferase
EX353_RS16035	COG0151	Belongs to the GarS family
EX353_RS16045	COG4191	Histidine kinase
EX353_RS16050	COG3678	ATP-independent chaperone mediated protein folding
EX353_RS16085	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EX353_RS16100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EX353_RS16105	COG2104	thiamine diphosphate biosynthetic process
EX353_RS16120	COG3706	GGDEF domain
EX353_RS16130	COG1447	Phosphotransferase system cellobiose-specific component IIA
EX353_RS16135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EX353_RS16170	COG0250	Participates in transcription elongation, termination and antitermination
EX353_RS16250	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EX353_RS16260	COG1739	Uncharacterized protein family UPF0029
EX353_RS16305	COG0805	protein transport
EX353_RS16325	COG3165	ubiquinone biosynthetic process from chorismate
EX353_RS16355	COG0583	DNA-binding transcription factor activity
EX353_RS16360	COG0697	spore germination
EX353_RS16365	COG0561	phosphatase activity
EX353_RS16370	COG2267	carboxylic ester hydrolase activity
EX353_RS16375	COG1280	lysine exporter protein (LysE YggA)
EX353_RS16395	COG1280	lysine exporter protein (LysE YggA)
EX353_RS16425	COG0210	DNA helicase
EX353_RS16430	COG1011	Hydrolase
EX353_RS16460	COG3072	Adenylate cyclase
EX353_RS16475	COG2959	enzyme of heme biosynthesis
EX353_RS16480	COG3071	HemY protein
EX353_RS16525	COG2244	polysaccharide biosynthetic process
EX353_RS16530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EX353_RS16535	COG0456	acetyltransferase
EX353_RS16540	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EX353_RS16545	COG1088	dTDP-glucose 4,6-dehydratase activity
EX353_RS16550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EX353_RS16555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EX353_RS16565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EX353_RS16570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EX353_RS16580	COG3118	belongs to the thioredoxin family
EX353_RS16610	COG1811	Na channel or pump
EX353_RS16620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EX353_RS16625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EX353_RS16635	COG0583	DNA-binding transcription factor activity
EX353_RS16640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EX353_RS16655	COG3978	acetolactate synthase activity
EX353_RS16675	COG3085	chromosome segregation
EX353_RS16750	COG0583	DNA-binding transcription factor activity
EX353_RS16775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EX353_RS16790	COG3443	Belongs to the bacterial solute-binding protein 9 family
EX353_RS16795	COG2207	Transcriptional regulator
EX353_RS16805	COG0371	Dehydrogenase
EX353_RS16810	COG0697	spore germination
EX353_RS16820	COG0583	DNA-binding transcription factor activity
EX353_RS16830	COG0737	Belongs to the 5'-nucleotidase family
EX353_RS16840	COG0460	homoserine dehydrogenase
EX353_RS16840	COG0527	aspartate kinase activity
EX353_RS16845	COG0626	cystathionine gamma-synthase activity
EX353_RS16860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EX353_RS16865	COG1609	Transcriptional regulator
EX353_RS16870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EX353_RS16885	COG1575	Belongs to the MenA family. Type 1 subfamily
EX353_RS16905	COG3678	ATP-independent chaperone mediated protein folding
EX353_RS16910	COG0745	RESPONSE REGULATOR receiver
EX353_RS16915	COG2205	protein histidine kinase activity
EX353_RS16920	COG2258	MOSC domain
EX353_RS16925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EX353_RS16970	COG1129	ABC transporter
EX353_RS16975	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS16980	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS16985	COG1454	alcohol dehydrogenase
EX353_RS16995	COG2211	Major facilitator Superfamily
EX353_RS17050	COG3383	formate dehydrogenase (NAD+) activity
EX353_RS17050	COG0243	molybdopterin cofactor binding
EX353_RS17055	COG0243	molybdopterin cofactor binding
EX353_RS17055	COG3383	formate dehydrogenase (NAD+) activity
EX353_RS17060	COG0437	4 iron, 4 sulfur cluster binding
EX353_RS17065	COG2864	formate dehydrogenase
EX353_RS17080	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EX353_RS17090	COG0456	acetyltransferase
EX353_RS17105	COG1011	Hydrolase
EX353_RS17120	COG3852	Histidine kinase
EX353_RS17130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EX353_RS17165	COG0204	Acyl-transferase
EX353_RS17175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EX353_RS17180	COG3084	Protein conserved in bacteria
EX353_RS17190	COG1763	Mo-molybdopterin cofactor biosynthetic process
EX353_RS17215	COG2186	Transcriptional regulator
EX353_RS17220	COG0477	Major facilitator Superfamily
EX353_RS17225	COG1609	Transcriptional regulator
EX353_RS17230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EX353_RS17240	COG1172	Belongs to the binding-protein-dependent transport system permease family
EX353_RS17245	COG1129	ABC transporter
EX353_RS17275	COG1522	sequence-specific DNA binding
EX353_RS17280	COG0716	FMN binding
EX353_RS17295	COG3312	ion transport
EX353_RS17355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EX353_RS17360	COG0573	inorganic phosphate transmembrane transporter activity
EX353_RS17365	COG0581	inorganic phosphate transmembrane transporter activity
EX353_RS17370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EX353_RS17375	COG0704	Plays a role in the regulation of phosphate uptake
EX353_RS17390	COG2382	esterase
EX353_RS17395	COG0363	glucosamine-6-phosphate deaminase activity
EX353_RS17400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EX353_RS17410	COG2252	PERMEase
EX353_RS17415	COG0431	NADPH-dependent FMN reductase
EX353_RS17420	COG2091	lysine biosynthetic process via aminoadipic acid
EX353_RS17450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EX353_RS17480	COG0187	DNA topoisomerase II activity
EX353_RS17485	COG0561	phosphatase activity
EX353_RS17500	COG2186	Transcriptional regulator
EX353_RS17505	COG3734	2-keto-3-deoxy-galactonokinase
EX353_RS17510	COG0800	Aldolase
EX353_RS17525	COG2271	Major facilitator Superfamily
EX353_RS17530	COG0823	Involved in the tonB-independent uptake of proteins
EX353_RS17535	COG5645	(Lipo)protein
EX353_RS17560	COG2188	Transcriptional regulator
EX353_RS17575	COG2149	membrane
EX353_RS17595	COG2610	gluconate transmembrane transporter activity
EX353_RS17600	COG0583	DNA-binding transcription factor activity
EX353_RS17605	COG2814	Major facilitator Superfamily
EX353_RS17630	COG0028	Belongs to the TPP enzyme family
EX353_RS17635	COG0440	acetolactate synthase activity
EX353_RS17640	COG2197	response regulator
EX353_RS17650	COG2271	Major facilitator Superfamily
EX353_RS17695	COG2188	Transcriptional regulator
EX353_RS17720	COG4580	involved in the transport of maltose and maltodextrins
EX353_RS17725	COG1447	Phosphotransferase system cellobiose-specific component IIA
EX353_RS17730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS17730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS17740	COG1609	Transcriptional regulator
EX353_RS17750	COG3384	dioxygenase
EX353_RS17755	COG0583	DNA-binding transcription factor activity
EX353_RS17760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EX353_RS17765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EX353_RS17770	COG2828	Protein conserved in bacteria
EX353_RS17785	COG0697	spore germination
EX353_RS17790	COG1263	PTS System
EX353_RS17790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS17800	COG2814	Major facilitator Superfamily
EX353_RS17810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EX353_RS17840	COG0583	DNA-binding transcription factor activity
EX353_RS17865	COG1464	Belongs to the NlpA lipoprotein family
EX353_RS17880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EX353_RS17890	COG1064	alcohol dehydrogenase
EX353_RS17930	COG0582	viral genome integration into host DNA
EX353_RS17940	COG2211	Major facilitator Superfamily
EX353_RS17945	COG1501	Belongs to the glycosyl hydrolase 31 family
EX353_RS17955	COG1486	melibiose metabolic process
EX353_RS17960	COG1263	PTS System
EX353_RS17960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS17965	COG2982	Protein involved in outer membrane biogenesis
EX353_RS17970	COG2233	PERMEase
EX353_RS17975	COG0786	glutamate:sodium symporter activity
EX353_RS17995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EX353_RS18020	COG3152	Membrane
EX353_RS18030	COG1494	fructose-1,6-bisphosphatase
EX353_RS18035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EX353_RS18040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EX353_RS18045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EX353_RS18065	COG2860	membrane
EX353_RS18075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EX353_RS18075	COG2169	Transcriptional regulator
EX353_RS18080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EX353_RS18085	COG1561	YicC-like family, N-terminal region
EX353_RS18105	COG1131	(ABC) transporter
EX353_RS18110	COG0842	Transport permease protein
EX353_RS18140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EX353_RS18175	COG1519	Transferase
EX353_RS18180	COG1216	Glycosyl transferase, family 2
EX353_RS18185	COG0438	transferase activity, transferring glycosyl groups
EX353_RS18195	COG0859	PFAM glycosyl transferase family 9
EX353_RS18220	COG0859	PFAM glycosyl transferase family 9
EX353_RS18235	COG0156	8-amino-7-oxononanoate synthase activity
EX353_RS18245	COG0463	Glycosyl transferase, family 2
EX353_RS18250	COG2861	carbohydrate metabolic process
EX353_RS18255	COG4942	peptidase
EX353_RS18265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EX353_RS18270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EX353_RS18290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EX353_RS18300	COG2186	Transcriptional regulator
EX353_RS18320	COG3722	fumarate hydratase activity
EX353_RS18340	COG0625	glutathione transferase activity
EX353_RS18350	COG3276	selenocysteine insertion sequence binding
EX353_RS18355	COG1414	Transcriptional regulator
EX353_RS18360	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EX353_RS18365	COG3977	Valine--pyruvate aminotransferase
EX353_RS18370	COG0366	Alpha amylase catalytic
EX353_RS18375	COG2992	FlgJ-related protein
EX353_RS18380	COG1609	Transcriptional regulator
EX353_RS18380	COG2207	Transcriptional regulator
EX353_RS18385	COG4214	carbohydrate transport
EX353_RS18395	COG4213	ABC transporter substrate-binding protein
EX353_RS18415	COG4682	membrane
EX353_RS18420	COG4682	membrane
EX353_RS18425	COG3274	enterobacterial common antigen metabolic process
EX353_RS18455	COG0488	(ABC) transporter
EX353_RS18460	COG1278	Cold shock
EX353_RS18465	COG2944	sequence-specific DNA binding
EX353_RS18470	COG2814	Major facilitator Superfamily
EX353_RS18495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EX353_RS18505	COG1609	Transcriptional regulator
EX353_RS18510	COG2885	chlorophyll binding
EX353_RS18515	COG0243	molybdopterin cofactor binding
EX353_RS18520	COG0456	acetyltransferase
EX353_RS18525	COG2818	Glycosylase
EX353_RS18530	COG5571	outer membrane autotransporter
EX353_RS18535	COG2223	nitrite transmembrane transporter activity
EX353_RS18565	COG0747	negative chemotaxis
EX353_RS18570	COG0601	transmembrane transport
EX353_RS18575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS18580	COG0444	Belongs to the ABC transporter superfamily
EX353_RS18585	COG4608	Belongs to the ABC transporter superfamily
EX353_RS18600	COG2894	cell division
EX353_RS18610	COG1215	transferase activity, transferring glycosyl groups
EX353_RS18615	COG0457	Tetratricopeptide repeat
EX353_RS18630	COG2194	sulfuric ester hydrolase activity
EX353_RS18660	COG1215	transferase activity, transferring glycosyl groups
EX353_RS18665	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EX353_RS18670	COG3118	belongs to the thioredoxin family
EX353_RS18670	COG0457	Tetratricopeptide repeat
EX353_RS18675	COG2200	EAL domain
EX353_RS18675	COG2199	diguanylate cyclase activity
EX353_RS18685	COG0612	Peptidase, M16
EX353_RS18700	COG2982	Protein involved in outer membrane biogenesis
EX353_RS18705	COG0477	Major facilitator Superfamily
EX353_RS18710	COG1295	ribonuclease BN
EX353_RS18715	COG0583	DNA-binding transcription factor activity
EX353_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS18725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EX353_RS18735	COG1454	alcohol dehydrogenase
EX353_RS18745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EX353_RS18750	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EX353_RS18755	COG0671	phosphoesterase, PA-phosphatase related
EX353_RS18775	COG0589	response to stress
EX353_RS18785	COG0306	phosphate transporter
EX353_RS18790	COG2081	HI0933 family
EX353_RS18795	COG2239	Acts as a magnesium transporter
EX353_RS18810	COG1124	(ABC) transporter
EX353_RS18820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS18825	COG0601	transmembrane transport
EX353_RS18830	COG0747	negative chemotaxis
EX353_RS18845	COG3479	Phenolic acid decarboxylase
EX353_RS18885	COG0628	permease
EX353_RS18890	COG0477	Major facilitator Superfamily
EX353_RS18900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EX353_RS18915	COG3714	YhhN family
EX353_RS18925	COG3776	membrane
EX353_RS18930	COG0742	ribosomal rna small subunit methyltransferase
EX353_RS18935	COG0552	protein localization to endoplasmic reticulum
EX353_RS18940	COG2884	Cell division ATP-binding protein ftsE
EX353_RS18945	COG2177	Part of the ABC transporter FtsEX involved in
EX353_RS18960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EX353_RS18975	COG0683	leucine binding
EX353_RS18990	COG0683	leucine binding
EX353_RS18995	COG0559	Belongs to the binding-protein-dependent transport system permease family
EX353_RS19045	COG0584	glycerophosphoryl diester phosphodiesterase
EX353_RS19055	COG0405	Gamma-glutamyltransferase
EX353_RS19060	COG1247	-acetyltransferase
EX353_RS19070	COG0673	inositol 2-dehydrogenase activity
EX353_RS19075	COG1741	Belongs to the pirin family
EX353_RS19080	COG1609	Transcriptional regulator
EX353_RS19085	COG3265	gluconokinase activity
EX353_RS19090	COG2610	gluconate transmembrane transporter activity
EX353_RS19100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EX353_RS19125	COG0058	SHG alpha-glucan phosphorylase activity
EX353_RS19130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EX353_RS19145	COG1349	DNA-binding transcription factor activity
EX353_RS19160	COG0058	SHG alpha-glucan phosphorylase activity
EX353_RS19165	COG1640	4-alpha-glucanotransferase
EX353_RS19170	COG2610	gluconate transmembrane transporter activity
EX353_RS19180	COG1040	competence protein
EX353_RS19205	COG1918	ferrous iron import across plasma membrane
EX353_RS19210	COG2183	response to ionizing radiation
EX353_RS19215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EX353_RS19240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EX353_RS19245	COG1011	Hydrolase
EX353_RS19255	COG0494	nUDIX hydrolase
EX353_RS19260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EX353_RS19285	COG4796	Type ii and iii secretion system protein
EX353_RS19305	COG3266	domain, Protein
EX353_RS19310	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EX353_RS19315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EX353_RS19340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EX353_RS19345	COG0402	S-adenosylhomocysteine deaminase activity
EX353_RS19350	COG0738	Major facilitator superfamily
EX353_RS19375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EX353_RS19380	COG1289	transmembrane transporter activity
EX353_RS19390	COG1765	OsmC-like protein
EX353_RS19395	COG3954	Phosphoribulokinase
EX353_RS19405	COG0429	hydrolase of the alpha beta-hydrolase fold
EX353_RS19415	COG0488	(ABC) transporter
EX353_RS19430	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EX353_RS19435	COG1047	Peptidyl-prolyl cis-trans
EX353_RS19445	COG0545	Peptidyl-prolyl cis-trans isomerase
EX353_RS19450	COG2964	Protein conserved in bacteria
EX353_RS19505	COG0051	transcription antitermination factor activity, RNA binding
EX353_RS19530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EX353_RS19545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EX353_RS19610	COG0201	protein transport
EX353_RS19635	COG0202	RNA polymerase activity
EX353_RS19650	COG0789	Transcriptional regulator
EX353_RS19655	COG3036	rescue of stalled ribosome
EX353_RS19685	COG0758	DNA mediated transformation
EX353_RS19695	COG0551	DNA topoisomerase type I activity
EX353_RS19715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EX353_RS19750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EX353_RS19755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS19760	COG1309	transcriptional regulator
EX353_RS19785	COG4145	pantothenate transmembrane transporter activity
EX353_RS19790	COG3924	membrane
EX353_RS19795	COG0439	Biotin carboxylase
EX353_RS19800	COG0511	ligase activity, forming carbon-carbon bonds
EX353_RS19825	COG2199	diguanylate cyclase activity
EX353_RS19825	COG2200	EAL domain
EX353_RS19830	COG1077	Cell shape determining protein MreB Mrl
EX353_RS19835	COG1792	Involved in formation and maintenance of cell shape
EX353_RS19840	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EX353_RS19850	COG1530	ribonuclease E activity
EX353_RS19855	COG3164	Protein of unknown function
EX353_RS19860	COG0312	modulator of DNA gyrase
EX353_RS19865	COG0583	DNA-binding transcription factor activity
EX353_RS19880	COG1289	transmembrane transporter activity
EX353_RS19885	COG2732	(Barnase) inhibitor
EX353_RS19900	COG3344	reverse transcriptase
EX353_RS19925	COG0471	metal ion transport
EX353_RS19930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EX353_RS19935	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EX353_RS19960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EX353_RS19965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EX353_RS19970	COG3105	Protein conserved in bacteria
EX353_RS19975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EX353_RS19995	COG0625	glutathione transferase activity
EX353_RS20000	COG2969	positive regulation of protein catabolic process
EX353_RS20010	COG0493	'glutamate synthase
EX353_RS20015	COG0067	glutamate synthase
EX353_RS20015	COG0070	glutamate synthase
EX353_RS20015	COG0069	glutamate synthase activity
EX353_RS20020	COG1242	4 iron, 4 sulfur cluster binding
EX353_RS20025	COG2271	Major facilitator Superfamily
EX353_RS20030	COG1063	alcohol dehydrogenase
EX353_RS20035	COG1312	Catalyzes the dehydration of D-mannonate
EX353_RS20040	COG5002	protein histidine kinase activity
EX353_RS20040	COG0784	Response regulator, receiver
EX353_RS20040	COG2198	Histidine kinase
EX353_RS20045	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EX353_RS20050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EX353_RS20055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS20065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS20070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EX353_RS20075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EX353_RS20080	COG1137	ATPase activity
EX353_RS20085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EX353_RS20090	COG3117	lipopolysaccharide transmembrane transporter activity
EX353_RS20095	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EX353_RS20105	COG0530	calcium, potassium:sodium antiporter activity
EX353_RS20115	COG1127	ABC transporter
EX353_RS20120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EX353_RS20125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EX353_RS20130	COG2854	intermembrane phospholipid transfer
EX353_RS20135	COG3113	response to antibiotic
EX353_RS20140	COG5007	Belongs to the BolA IbaG family
EX353_RS20150	COG3423	Transcriptional regulator
EX353_RS20155	COG0142	geranyltranstransferase activity
EX353_RS20170	COG0697	spore germination
EX353_RS20180	COG2027	D-alanyl-D-alanine carboxypeptidase
EX353_RS20190	COG1534	Rna-binding protein
EX353_RS20200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EX353_RS20205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EX353_RS20215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EX353_RS20255	COG0195	Participates in both transcription termination and antitermination
EX353_RS20305	COG0814	amino acid
EX353_RS20310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EX353_RS20315	COG0826	peptidase U32
EX353_RS20320	COG0826	peptidase U32
EX353_RS20325	COG3154	lipid carrier protein
EX353_RS20330	COG3153	acetyltransferase
EX353_RS20345	COG0693	protein deglycase activity
EX353_RS20350	COG0702	epimerase
EX353_RS20355	COG0701	Predicted permease
EX353_RS20360	COG2823	Periplasmic or secreted lipoprotein
EX353_RS20380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EX353_RS20395	COG1063	alcohol dehydrogenase
EX353_RS20400	COG3775	system Galactitol-specific IIC component
EX353_RS20405	COG3414	Phosphotransferase system galactitol-specific IIB component
EX353_RS20410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS20420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS20420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS20425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EX353_RS20425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EX353_RS20425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS20430	COG1105	Belongs to the carbohydrate kinase PfkB family
EX353_RS20440	COG1349	DNA-binding transcription factor activity
EX353_RS20445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EX353_RS20450	COG2721	sulfolactate sulfo-lyase activity
EX353_RS20460	COG2271	Major facilitator Superfamily
EX353_RS20470	COG2084	Dehydrogenase
EX353_RS20475	COG1929	Belongs to the glycerate kinase type-1 family
EX353_RS20495	COG1741	Belongs to the pirin family
EX353_RS20500	COG0583	DNA-binding transcription factor activity
EX353_RS20505	COG3152	Membrane
EX353_RS20510	COG0435	Glutathione S-transferase
EX353_RS20515	COG2259	Doxx family
EX353_RS20525	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
EX353_RS20530	COG4575	ribosome binding
EX353_RS20535	COG1422	Protein of unknown function (DUF1090)
EX353_RS20545	COG0586	Pfam SNARE associated Golgi protein
EX353_RS20555	COG2271	Major facilitator Superfamily
EX353_RS20565	COG2721	sulfolactate sulfo-lyase activity
EX353_RS20580	COG0861	Integral membrane protein TerC family
EX353_RS20585	COG0673	inositol 2-dehydrogenase activity
EX353_RS20590	COG1451	nucleotide metabolic process
EX353_RS20610	COG1902	pentaerythritol trinitrate reductase activity
EX353_RS20610	COG0446	pyridine nucleotide-disulphide oxidoreductase
EX353_RS20660	COG1695	Transcriptional regulator
EX353_RS20665	COG2375	cellular response to nickel ion
EX353_RS20680	COG1461	Dihydroxyacetone kinase
EX353_RS20685	COG2376	Dihydroxyacetone kinase
EX353_RS20760	COG3247	response to pH
EX353_RS20770	COG2205	protein histidine kinase activity
EX353_RS20770	COG2198	Histidine kinase
EX353_RS20770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS20770	COG0784	Response regulator, receiver
EX353_RS20775	COG2197	response regulator
EX353_RS20800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EX353_RS20805	COG0358	DNA primase activity
EX353_RS20810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EX353_RS20875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EX353_RS20890	COG4991	sh3 domain protein
EX353_RS20895	COG3025	triphosphatase activity
EX353_RS20915	COG2960	long-chain fatty acid transporting porin activity
EX353_RS20930	COG3384	dioxygenase
EX353_RS20935	COG0754	glutathionylspermidine amidase activity
EX353_RS20950	COG0494	nUDIX hydrolase
EX353_RS20955	COG3151	Protein conserved in bacteria
EX353_RS20960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EX353_RS20965	COG3150	esterase
EX353_RS20975	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EX353_RS20980	COG2249	NAD(P)H dehydrogenase (quinone) activity
EX353_RS20985	COG0642	Histidine kinase
EX353_RS20995	COG3111	PFAM Bacterial OB fold (BOF) protein
EX353_RS21000	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EX353_RS21005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EX353_RS21010	COG0204	Acyl-transferase
EX353_RS21015	COG2132	Multicopper oxidase
EX353_RS21020	COG1032	radical SAM domain protein
EX353_RS21030	COG0656	L-ascorbic acid biosynthetic process
EX353_RS21035	COG1979	alcohol dehydrogenase
EX353_RS21040	COG2207	Transcriptional regulator
EX353_RS21045	COG0586	Pfam SNARE associated Golgi protein
EX353_RS21050	COG0626	cystathionine gamma-synthase activity
EX353_RS21060	COG0848	biopolymer transport protein
EX353_RS21065	COG2211	Major facilitator Superfamily
EX353_RS21090	COG0625	glutathione transferase activity
EX353_RS21100	COG0754	glutathionylspermidine amidase activity
EX353_RS21105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EX353_RS21130	COG0626	cystathionine gamma-synthase activity
EX353_RS21175	COG1811	Na channel or pump
EX353_RS21190	COG2211	Major facilitator Superfamily
EX353_RS21205	COG1194	a g-specific adenine glycosylase
EX353_RS21215	COG3171	Protein conserved in bacteria
EX353_RS21225	COG4214	carbohydrate transport
EX353_RS21240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EX353_RS21255	COG0762	integral membrane protein
EX353_RS21260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EX353_RS21265	COG2805	Type II/IV secretion system protein
EX353_RS21285	COG0189	ligase activity
EX353_RS21290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EX353_RS21295	COG2356	endonuclease I
EX353_RS21305	COG2814	Major facilitator Superfamily
EX353_RS21340	COG0501	Belongs to the peptidase M48B family
EX353_RS21360	COG0191	fructose-bisphosphate aldolase activity
EX353_RS21365	COG0668	transmembrane transport
EX353_RS21375	COG2968	Membrane
EX353_RS21390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EX353_RS21395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EX353_RS21415	COG0006	proline dipeptidase activity
EX353_RS21420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EX353_RS21425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EX353_RS21445	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS21450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EX353_RS21470	COG2723	6-phospho-beta-galactosidase activity
EX353_RS21475	COG1737	Transcriptional regulator
EX353_RS21485	COG1272	protein, Hemolysin III
EX353_RS21495	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EX353_RS21505	COG0716	FMN binding
EX353_RS21510	COG4974	Belongs to the 'phage' integrase family
EX353_RS21520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EX353_RS21545	COG4942	peptidase
EX353_RS21555	COG2814	Major facilitator Superfamily
EX353_RS21570	COG0667	Aldo Keto reductase
EX353_RS21610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EX353_RS21615	COG1393	Belongs to the ArsC family
EX353_RS21630	COG1538	Outer membrane efflux protein
EX353_RS21635	COG1289	transmembrane transporter activity
EX353_RS21650	COG3592	Divergent 4Fe-4S mono-cluster
EX353_RS21655	COG2388	GCN5-related N-acetyl-transferase
EX353_RS21665	COG3539	Fimbrial protein
EX353_RS21670	COG3539	Fimbrial protein
EX353_RS21675	COG3539	Fimbrial protein
EX353_RS21680	COG3188	usher protein
EX353_RS21685	COG3121	Chaperone
EX353_RS21690	COG3539	Fimbrial protein
EX353_RS21700	COG4974	Belongs to the 'phage' integrase family
EX353_RS21705	COG0582	viral genome integration into host DNA
EX353_RS21715	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EX353_RS21720	COG1846	Transcriptional regulator
EX353_RS21725	COG0697	spore germination
EX353_RS21785	COG0667	Aldo Keto reductase
EX353_RS21790	COG0814	amino acid
EX353_RS21805	COG0183	Belongs to the thiolase family
EX353_RS21815	COG0823	Involved in the tonB-independent uptake of proteins
EX353_RS21820	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS21825	COG2814	Major facilitator Superfamily
EX353_RS21855	COG3842	ATPase activity
EX353_RS21860	COG0395	ABC-type sugar transport system, permease component
EX353_RS21865	COG1175	transmembrane transport
EX353_RS21870	COG1917	Cupin 2, conserved barrel domain protein
EX353_RS21875	COG1794	racemase activity, acting on amino acids and derivatives
EX353_RS21880	COG0583	DNA-binding transcription factor activity
EX353_RS21890	COG1609	Transcriptional regulator
EX353_RS21895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS21900	COG2723	6-phospho-beta-galactosidase activity
EX353_RS21905	COG2186	Transcriptional regulator
EX353_RS21915	COG1609	Transcriptional regulator
EX353_RS21940	COG0667	Aldo Keto reductase
EX353_RS21950	COG0861	Integral membrane protein TerC family
EX353_RS21985	COG2165	general secretion pathway protein
EX353_RS21990	COG4795	General secretion pathway protein
EX353_RS22000	COG4967	type IV pilus modification protein PilV
EX353_RS22005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EX353_RS22010	COG1025	Belongs to the peptidase M16 family
EX353_RS22015	COG1074	ATP-dependent DNA helicase activity
EX353_RS22020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EX353_RS22030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EX353_RS22030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EX353_RS22035	COG0860	N-Acetylmuramoyl-L-alanine amidase
EX353_RS22040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EX353_RS22070	COG4656	Part of a membrane complex involved in electron transport
EX353_RS22075	COG1454	alcohol dehydrogenase
EX353_RS22075	COG1012	belongs to the aldehyde dehydrogenase family
EX353_RS22105	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
EX353_RS22270	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EX353_RS22275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EX353_RS22280	COG2166	iron-sulfur cluster assembly
EX353_RS22285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EX353_RS22295	COG0583	DNA-binding transcription factor activity
EX353_RS22300	COG2363	Small membrane protein
EX353_RS22310	COG1349	DNA-binding transcription factor activity
EX353_RS22330	COG0738	Major facilitator superfamily
EX353_RS22335	COG0235	Class ii aldolase
EX353_RS22340	COG1454	alcohol dehydrogenase
EX353_RS22355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EX353_RS22375	COG2011	ABC-type metal ion transport system permease component
EX353_RS22380	COG1464	Belongs to the NlpA lipoprotein family
EX353_RS22390	COG0477	Major facilitator Superfamily
EX353_RS22400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EX353_RS22405	COG1760	l-serine dehydratase
EX353_RS22410	COG0814	amino acid
EX353_RS22415	COG1611	Belongs to the LOG family
EX353_RS22430	COG3098	single-species biofilm formation
EX353_RS22435	COG0564	pseudouridine synthase activity
EX353_RS22440	COG0716	FMN binding
EX353_RS22450	COG2271	Major facilitator Superfamily
EX353_RS22455	COG4948	Mandelate Racemase Muconate Lactonizing
EX353_RS22460	COG4948	Mandelate Racemase Muconate Lactonizing
EX353_RS22465	COG1929	Belongs to the glycerate kinase type-1 family
EX353_RS22475	COG3850	Histidine kinase
EX353_RS22475	COG3437	response regulator, receiver
EX353_RS22475	COG2205	protein histidine kinase activity
EX353_RS22475	COG4999	Histidine kinase
EX353_RS22485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EX353_RS22490	COG3956	TIGRFAM MazG family protein
EX353_RS22510	COG0602	queuosine metabolic process
EX353_RS22515	COG0720	synthase
EX353_RS22535	COG2234	aminopeptidase activity
EX353_RS22595	COG1388	LysM domain
EX353_RS22595	COG4942	peptidase
EX353_RS22600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EX353_RS22625	COG0163	prenyltransferase activity
EX353_RS22630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EX353_RS22660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS22665	COG4558	Periplasmic binding protein
EX353_RS22670	COG3720	iron ion transport
EX353_RS22715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EX353_RS22720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EX353_RS22725	COG1121	(ABC) transporter
EX353_RS22735	COG1609	Transcriptional regulator
EX353_RS22740	COG1940	carbohydrate kinase activity
EX353_RS22745	COG1447	Phosphotransferase system cellobiose-specific component IIA
EX353_RS22750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS22755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS22760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EX353_RS22770	COG4580	involved in the transport of maltose and maltodextrins
EX353_RS22780	COG2723	6-phospho-beta-galactosidase activity
EX353_RS22790	COG0309	Hydrogenase expression formation protein (HypE)
EX353_RS22795	COG0409	Hydrogenase expression formation protein
EX353_RS22800	COG0298	carbon dioxide binding
EX353_RS22805	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EX353_RS22825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EX353_RS22830	COG0651	ATP synthesis coupled electron transport
EX353_RS22835	COG0650	Formate hydrogenlyase subunit 4
EX353_RS22840	COG3261	NADH dehydrogenase
EX353_RS22840	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EX353_RS22845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EX353_RS22850	COG3260	NADH ubiquinone oxidoreductase 20
EX353_RS22860	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EX353_RS22870	COG2723	6-phospho-beta-galactosidase activity
EX353_RS22875	COG1263	PTS System
EX353_RS22875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EX353_RS22880	COG1609	Transcriptional regulator
EX353_RS22885	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EX353_RS22890	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EX353_RS22895	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EX353_RS22925	COG1349	DNA-binding transcription factor activity
EX353_RS22930	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS22935	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS22945	COG3732	PTS system glucitol sorbitol-specific
EX353_RS22950	COG3730	PTS system glucitol sorbitol-specific
EX353_RS22955	COG2951	lytic endotransglycosylase activity
EX353_RS22965	COG1121	(ABC) transporter
EX353_RS22970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EX353_RS22980	COG1546	Belongs to the CinA family
EX353_RS23005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EX353_RS23035	COG2823	Periplasmic or secreted lipoprotein
EX353_RS23040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EX353_RS23045	COG1238	metal cluster binding
EX353_RS23065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EX353_RS23070	COG2814	Major facilitator Superfamily
EX353_RS23075	COG1566	PFAM secretion protein HlyD family protein
EX353_RS23080	COG1846	Transcriptional regulator
EX353_RS23090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EX353_RS23100	COG4176	ABC-type proline glycine betaine transport system permease component
EX353_RS23115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EX353_RS23125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EX353_RS23130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EX353_RS23135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EX353_RS23140	COG4575	ribosome binding
EX353_RS23165	COG2916	Histone family protein nucleoid-structuring protein H-NS
EX353_RS23180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EX353_RS23185	COG0640	Transcriptional regulator
EX353_RS23195	COG0583	DNA-binding transcription factor activity
EX353_RS23200	COG3284	Transcriptional regulator
EX353_RS23230	COG2197	response regulator
EX353_RS23245	COG3188	usher protein
EX353_RS23265	COG3121	Chaperone
EX353_RS23270	COG3539	Fimbrial protein
EX353_RS23305	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS23315	COG0235	Class ii aldolase
EX353_RS23325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EX353_RS23355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EX353_RS23405	COG0431	NADPH-dependent FMN reductase
EX353_RS23420	COG2271	Major facilitator Superfamily
EX353_RS23435	COG3622	Belongs to the hyi family
EX353_RS23460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EX353_RS23465	COG3708	Transcriptional regulator
EX353_RS23465	COG2207	Transcriptional regulator
EX353_RS23570	COG1484	DNA-dependent DNA replication
EX353_RS23575	COG0305	Participates in initiation and elongation during chromosome replication
EX353_RS23580	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
EX353_RS23605	COG3179	chitinase
EX353_RS23795	COG2867	negative regulation of translational initiation
EX353_RS23810	COG0497	DNA recombination
EX353_RS23830	COG4536	flavin adenine dinucleotide binding
EX353_RS23835	COG4137	Cytochrome C assembly protein
EX353_RS23840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EX353_RS23875	COG2885	chlorophyll binding
EX353_RS23880	COG2199	diguanylate cyclase activity
EX353_RS23890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EX353_RS23895	COG0287	Prephenate dehydrogenase
EX353_RS23895	COG1605	Chorismate mutase
EX353_RS23905	COG1605	Chorismate mutase
EX353_RS23905	COG0077	Prephenate dehydratase
EX353_RS23915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EX353_RS23920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EX353_RS23935	COG0542	response to heat
EX353_RS23960	COG0477	Major facilitator Superfamily
EX353_RS23965	COG5544	Lipoprotein
EX353_RS23970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EX353_RS23980	COG3148	PFAM DTW domain containing protein
EX353_RS23985	COG3118	belongs to the thioredoxin family
EX353_RS23990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EX353_RS24005	COG0513	Belongs to the DEAD box helicase family
EX353_RS24015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EX353_RS24030	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
EX353_RS24035	COG3026	antisigma factor binding
EX353_RS24040	COG3086	response to oxidative stress
EX353_RS24050	COG0681	Belongs to the peptidase S26 family
EX353_RS24070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EX353_RS24080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EX353_RS24085	COG1737	Transcriptional regulator
EX353_RS24090	COG0560	Phosphoserine phosphatase
EX353_RS24105	COG0047	phosphoribosylformylglycinamidine synthase activity
EX353_RS24105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EX353_RS24110	COG2205	protein histidine kinase activity
EX353_RS24115	COG3170	Tfp pilus assembly protein FimV
EX353_RS24120	COG2204	response regulator
EX353_RS24125	COG0347	Belongs to the P(II) protein family
EX353_RS24130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EX353_RS24130	COG1017	nitric oxide dioxygenase activity
EX353_RS24140	COG2259	Doxx family
EX353_RS24145	COG1940	carbohydrate kinase activity
EX353_RS24150	COG0457	Tetratricopeptide repeat
EX353_RS24155	COG0477	Major facilitator Superfamily
EX353_RS24155	COG2814	Major facilitator Superfamily
EX353_RS24160	COG2017	converts alpha-aldose to the beta-anomer
EX353_RS24165	COG2814	Major facilitator Superfamily
EX353_RS24170	COG3711	transcriptional antiterminator
EX353_RS24175	COG3683	transport system, periplasmic component
EX353_RS24180	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EX353_RS24210	COG0822	iron-sulfur transferase activity
EX353_RS24230	COG0633	Ferredoxin
EX353_RS24235	COG2975	iron-sulfur cluster assembly
EX353_RS24255	COG2897	thiosulfate sulfurtransferase activity
EX353_RS24260	COG2373	Large extracellular alpha-helical protein
EX353_RS24265	COG4953	penicillin-binding protein 1C
EX353_RS24300	COG2976	Protein conserved in bacteria
EX353_RS24320	COG1645	bacterial-type flagellum-dependent swarming motility
EX353_RS24330	COG0517	IMP dehydrogenase activity
EX353_RS24330	COG0516	GMP reductase activity
EX353_RS24340	COG3119	arylsulfatase activity
EX353_RS24345	COG0641	radical SAM
EX353_RS24365	COG2200	EAL domain
EX353_RS24380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EX353_RS24395	COG2723	6-phospho-beta-galactosidase activity
EX353_RS24405	COG2233	PERMEase
EX353_RS24420	COG1393	Belongs to the ArsC family
EX353_RS24425	COG4783	chaperone-mediated protein folding
EX353_RS24430	COG0628	permease
EX353_RS24435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EX353_RS24440	COG2716	regulation of RNA biosynthetic process
EX353_RS24450	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EX353_RS24460	COG2321	neutral zinc metallopeptidase
EX353_RS24465	COG1444	tRNA N-acetyltransferase activity
EX353_RS24470	COG0400	carboxylic ester hydrolase activity
EX353_RS24485	COG1393	Belongs to the ArsC family
EX353_RS24495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EX353_RS24505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EX353_RS24505	COG0493	'glutamate synthase
EX353_RS24515	COG5342	invasion associated locus B
EX353_RS24520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EX353_RS24525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EX353_RS24535	COG4810	utilization protein
EX353_RS24625	COG0860	N-Acetylmuramoyl-L-alanine amidase
EX353_RS24645	COG2837	iron assimilation
EX353_RS24655	COG4150	thiosulfate binding
EX353_RS24660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EX353_RS24665	COG4208	sulfate ABC transporter
EX353_RS24670	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EX353_RS24680	COG4319	ketosteroid isomerase
EX353_RS24715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EX353_RS24735	COG3530	Putative quorum-sensing-regulated virulence factor
EX353_RS24740	COG0385	Bile acid
EX353_RS24745	COG0583	DNA-binding transcription factor activity
EX353_RS24785	COG3415	Transposase
EX353_RS24790	COG3415	Transposase
EX353_RS24805	COG2199	diguanylate cyclase activity
EX353_RS24805	COG2200	EAL domain
EX353_RS24810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EX353_RS24825	COG0667	Aldo Keto reductase
EX353_RS24830	COG3961	Belongs to the TPP enzyme family
EX353_RS24845	COG3279	Response regulator of the LytR AlgR family
EX353_RS24850	COG3275	phosphorelay sensor kinase activity
EX353_RS24860	COG0436	Aminotransferase
EX353_RS24870	COG2807	transmembrane transport
EX353_RS24875	COG0590	tRNA wobble adenosine to inosine editing
EX353_RS24880	COG0583	DNA-binding transcription factor activity
EX353_RS24990	COG0305	Participates in initiation and elongation during chromosome replication
EX353_RS25235	COG0582	viral genome integration into host DNA
EX353_RS25245	COG2116	formate transmembrane transporter activity
EX353_RS25250	COG2853	Lipoprotein
EX353_RS25260	COG3691	Protein conserved in bacteria
EX353_RS25275	COG2062	phosphohistidine phosphatase, SixA
EX353_RS25300	COG0730	response to heat
EX353_RS25305	COG3101	peptidyl-lysine hydroxylation
EX353_RS25320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EX353_RS25340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EX353_RS25350	COG0586	Pfam SNARE associated Golgi protein
EX353_RS25360	COG0285	dihydrofolate synthase activity
EX353_RS25365	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EX353_RS25370	COG1286	toxin biosynthetic process
EX353_RS25375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EX353_RS25380	COG0163	prenyltransferase activity
EX353_RS25400	COG4160	amino acid transport
EX353_RS25405	COG4598	ABC transporter
EX353_RS25415	COG1090	epimerase
EX353_RS25420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EX353_RS25425	COG0625	glutathione transferase activity
EX353_RS25430	COG0625	glutathione transferase activity
EX353_RS25435	COG0622	Phosphoesterase
EX353_RS25440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EX353_RS25445	COG0857	belongs to the CobB CobQ family
EX353_RS25445	COG0280	phosphate acetyltransferase
EX353_RS25465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EX353_RS25470	COG0471	metal ion transport
EX353_RS25470	COG0490	domain, Protein
EX353_RS25480	COG0436	Aminotransferase
EX353_RS25485	COG0583	DNA-binding transcription factor activity
EX353_RS25535	COG0839	Belongs to the complex I subunit 6 family
EX353_RS25545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EX353_RS25550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EX353_RS25565	COG2153	protein acetylation
EX353_RS25570	COG1169	isochorismate synthase
EX353_RS25595	COG0318	PFAM AMP-dependent synthetase and ligase
EX353_RS25605	COG5464	transposase or invertase
EX353_RS25620	COG1414	Transcriptional regulator
EX353_RS25630	COG2271	Major facilitator Superfamily
EX353_RS25640	COG0247	lactate metabolic process
EX353_RS25650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EX353_RS25655	COG2271	Major facilitator Superfamily
EX353_RS25660	COG0584	glycerophosphoryl diester phosphodiesterase
EX353_RS25670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EX353_RS25700	COG0784	Response regulator, receiver
EX353_RS25700	COG2205	protein histidine kinase activity
EX353_RS25710	COG0642	Histidine kinase
EX353_RS25710	COG2198	Histidine kinase
EX353_RS25725	COG2169	Transcriptional regulator
EX353_RS25725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EX353_RS25730	COG3145	DNA-N1-methyladenine dioxygenase activity
EX353_RS25735	COG4615	Cyclic peptide transporter
EX353_RS25740	COG2239	Acts as a magnesium transporter
EX353_RS25745	COG0659	secondary active sulfate transmembrane transporter activity
EX353_RS25760	COG0628	permease
EX353_RS25785	COG1349	DNA-binding transcription factor activity
EX353_RS25790	COG0494	nUDIX hydrolase
EX353_RS25810	COG1061	Type III restriction enzyme res subunit
EX353_RS25815	COG1187	pseudouridine synthase activity
EX353_RS25820	COG2814	Major facilitator Superfamily
EX353_RS25830	COG4172	Belongs to the ABC transporter superfamily
EX353_RS25835	COG4239	(ABC) transporter, permease
EX353_RS25840	COG4174	ABC transporter (Permease)
EX353_RS25845	COG4166	transmembrane transport
EX353_RS25850	COG2200	EAL domain
EX353_RS25855	COG0791	NLP P60 protein
EX353_RS25860	COG0671	phosphoesterase, PA-phosphatase related
EX353_RS25870	COG0246	Mannitol dehydrogenase
EX353_RS25875	COG1312	Catalyzes the dehydration of D-mannonate
EX353_RS25890	COG2814	Major facilitator Superfamily
EX353_RS25900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS25900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EX353_RS25905	COG1105	Belongs to the carbohydrate kinase PfkB family
EX353_RS25910	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EX353_RS25910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EX353_RS25910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EX353_RS25920	COG2855	membrane
EX353_RS25930	COG0583	DNA-binding transcription factor activity
EX353_RS25935	COG0833	amino acid
EX353_RS25965	COG2311	Membrane
EX353_RS25980	COG1129	ABC transporter
EX353_RS25990	COG2949	membrane
EX353_RS26005	COG1346	cytolysis
EX353_RS26015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EX353_RS26020	COG3659	wide pore channel activity
EX353_RS26035	COG2723	6-phospho-beta-galactosidase activity
EX353_RS26045	COG1538	Outer membrane efflux protein
EX353_RS26050	COG0586	Pfam SNARE associated Golgi protein
EX353_RS26060	COG1686	Belongs to the peptidase S11 family
EX353_RS26070	COG0277	FAD linked oxidase domain protein
EX353_RS26075	COG1472	Belongs to the glycosyl hydrolase 3 family
EX353_RS26080	COG1732	Glycine betaine
EX353_RS26085	COG1174	glycine betaine transport
EX353_RS26090	COG1125	glycine betaine transport
EX353_RS26095	COG1174	glycine betaine transport
EX353_RS26105	COG3275	phosphorelay sensor kinase activity
EX353_RS26115	COG4807	Protein conserved in bacteria
EX353_RS26135	COG5455	response to cobalt ion
EX353_RS26140	COG0583	DNA-binding transcription factor activity
EX353_RS26145	COG2252	PERMEase
EX353_RS26195	COG0351	phosphomethylpyrimidine kinase
EX353_RS26200	COG1830	Aldolase
EX353_RS26235	COG1070	Carbohydrate kinase
EX353_RS26245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EX353_RS26250	COG4948	Mandelate Racemase Muconate Lactonizing
EX353_RS26255	COG0747	negative chemotaxis
EX353_RS26260	COG0601	transmembrane transport
EX353_RS26265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS26270	COG0444	Belongs to the ABC transporter superfamily
EX353_RS26275	COG4608	Belongs to the ABC transporter superfamily
EX353_RS26285	COG0826	peptidase U32
EX353_RS26290	COG0745	RESPONSE REGULATOR receiver
EX353_RS26295	COG2205	protein histidine kinase activity
EX353_RS26320	COG1301	dicarboxylic acid transport
EX353_RS26335	COG5002	protein histidine kinase activity
EX353_RS26340	COG0443	Heat shock 70 kDa protein
EX353_RS26345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EX353_RS26360	COG2982	Protein involved in outer membrane biogenesis
EX353_RS26365	COG1253	flavin adenine dinucleotide binding
EX353_RS26420	COG0110	maltose O-acetyltransferase activity
EX353_RS26425	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EX353_RS26430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EX353_RS26435	COG1051	belongs to the nudix hydrolase family
EX353_RS26440	COG0297	glycogen (starch) synthase activity
EX353_RS26570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EX353_RS26600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EX353_RS26605	COG0583	DNA-binding transcription factor activity
EX353_RS26615	COG0531	amino acid
EX353_RS26620	COG0640	Transcriptional regulator
EX353_RS26625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EX353_RS26630	COG2925	Exonuclease
EX353_RS26645	COG1289	transmembrane transporter activity
EX353_RS26665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EX353_RS26675	COG1942	4-Oxalocrotonate Tautomerase
EX353_RS26680	COG0583	DNA-binding transcription factor activity
EX353_RS26685	COG0095	Lipoate-protein ligase
EX353_RS26690	COG0477	Major facilitator Superfamily
EX353_RS26720	COG3615	Tellurite resistance protein tehB
EX353_RS26745	COG3706	GGDEF domain
EX353_RS26765	COG0534	Mate efflux family protein
EX353_RS26775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EX353_RS26795	COG0604	alcohol dehydrogenase
EX353_RS26800	COG1309	transcriptional regulator
EX353_RS26805	COG0025	NhaP-type Na H and K H
EX353_RS26825	COG1376	ErfK ybiS ycfS ynhG family protein
EX353_RS26840	COG0251	oxidation-reduction process
EX353_RS26890	COG2003	Belongs to the UPF0758 family
EX353_RS26945	COG3504	Conjugal transfer protein
EX353_RS27025	COG4771	TonB-dependent receptor
EX353_RS27030	COG1021	2,3-dihydroxybenzoate-AMP ligase
EX353_RS27065	COG2382	esterase
EX353_RS27085	COG1475	DNA binding
EX353_RS27115	COG1595	DNA-templated transcription, initiation
EX353_RS27125	COG4772	TonB-dependent receptor
EX353_RS27130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EX353_RS27145	COG5642	Protein of unknown function (DUF2384)
EX353_RS27150	COG5654	RES domain protein
EX353_RS27180	COG0656	L-ascorbic acid biosynthetic process
EX353_RS27205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EX353_RS27250	COG0735	belongs to the Fur family
EX353_RS27255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EX353_RS27260	COG0523	cobalamin synthesis protein
EX353_RS27290	COG0523	cobalamin synthesis protein
EX353_RS27330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EX353_RS27425	COG4680	protein conserved in bacteria
EX353_RS27430	COG5499	transcription regulator containing HTH domain
EX353_RS27465	COG2205	protein histidine kinase activity
EX353_RS27470	COG0745	RESPONSE REGULATOR receiver
EX353_RS27475	COG1276	copper resistance
EX353_RS27480	COG2372	response to copper ion
EX353_RS27485	COG3667	copper resistance
EX353_RS27490	COG2132	Multicopper oxidase
EX353_RS27500	COG0739	heme binding
EX353_RS27805	COG0789	Transcriptional regulator
EX353_RS27845	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
EX353_RS27865	COG4245	von Willebrand factor, type A
EX353_RS27870	COG4245	von Willebrand factor, type A
EX353_RS27880	COG4245	von Willebrand factor, type A
EX353_RS27900	COG1358	cellular component organization or biogenesis
EX353_RS27995	COG0604	alcohol dehydrogenase
EX353_RS27995	COG1028	Short-chain dehydrogenase reductase Sdr
EX353_RS27995	COG3321	synthase
EX353_RS28010	COG1522	sequence-specific DNA binding
EX353_RS28090	COG1956	GAF domain-containing protein
EX353_RS28095	COG1956	GAF domain-containing protein
EX353_RS28200	COG0523	cobalamin synthesis protein
EX353_RS28205	COG0500	methyltransferase
EX353_RS28220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EX353_RS28230	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EX353_RS28265	COG0500	methyltransferase
EX353_RS28495	COG0616	signal peptide processing
EX353_RS28540	COG1525	nuclease
EX353_RS28615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EX353_RS28700	COG1192	Involved in chromosome partitioning
EX353_RS28780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EX353_RS28895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EX353_RS28920	COG5001	Diguanylate cyclase
EX353_RS28955	COG0714	Associated with various cellular activities
EX353_RS28965	COG0629	single-stranded DNA binding
EX353_RS29015	COG0633	Ferredoxin
EX353_RS29375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EX353_RS29380	COG3041	Addiction module toxin RelE StbE family
EX353_RS29445	COG0110	maltose O-acetyltransferase activity
EX353_RS29570	COG2801	Transposase and inactivated derivatives
EX353_RS29655	COG3436	PFAM IS66 Orf2 family protein
EX353_RS29660	COG4372	Transposase
EX353_RS29665	COG1196	nuclear chromosome segregation
EX353_RS29875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EX353_RS30200	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EX353_RS30225	COG3318	Belongs to the UPF0149 family
EX353_RS30225	COG3012	SEC-C Motif Domain Protein
EX353_RS30230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EX353_RS30280	COG3436	PFAM IS66 Orf2 family protein
EX353_RS30285	COG4372	Transposase
EX353_RS30410	COG1702	phosphate starvation-inducible protein PhoH
EX353_RS30420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EX353_RS30505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EX353_RS30575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EX353_RS30580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EX353_RS30590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EX353_RS30605	COG0237	dephospho-CoA kinase activity
EX353_RS30635	COG0328	RNA-DNA hybrid ribonuclease activity
EX353_RS30790	COG1475	DNA binding
EX353_RS30795	COG1475	DNA binding
EX353_RS30800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EX353_RS30890	COG3941	tape measure
EX353_RS31035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EX353_RS31040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EX353_RS31150	COG3754	Rhamnan synthesis protein F
EX353_RS31175	COG1091	dTDP-4-dehydrorhamnose reductase activity
EX353_RS31215	COG3173	Aminoglycoside phosphotransferase
EX353_RS31220	COG0488	(ABC) transporter
EX353_RS31235	COG0482	sulfurtransferase activity
EX353_RS31295	COG1192	Involved in chromosome partitioning
EX353_RS31335	COG0484	heat shock protein binding