locus-tag	class	description
ISA71_RS00150	COG3179	chitinase
ISA71_RS00175	COG5484	DNA packaging
ISA71_RS00175	COG3728	DNA packaging
ISA71_RS00315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISA71_RS00335	COG2135	peptidase activity
ISA71_RS00365	COG1473	amidohydrolase
ISA71_RS00380	COG1842	Phage shock protein A
ISA71_RS00390	COG1983	PspC domain protein
ISA71_RS00400	COG3106	COG3106 Predicted ATPase
ISA71_RS00410	COG0583	DNA-binding transcription factor activity
ISA71_RS00415	COG1486	melibiose metabolic process
ISA71_RS00425	COG3180	Ammonia monooxygenase
ISA71_RS00430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISA71_RS00435	COG4948	Mandelate Racemase Muconate Lactonizing
ISA71_RS00440	COG2866	Carboxypeptidase
ISA71_RS00450	COG4166	transmembrane transport
ISA71_RS00480	COG0656	L-ascorbic acid biosynthetic process
ISA71_RS00485	COG3250	beta-galactosidase activity
ISA71_RS00550	COG0583	DNA-binding transcription factor activity
ISA71_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS00560	COG1078	dGTPase activity
ISA71_RS00565	COG0693	protein deglycase activity
ISA71_RS00590	COG2885	chlorophyll binding
ISA71_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS00700	COG1309	transcriptional regulator
ISA71_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS00725	COG0583	DNA-binding transcription factor activity
ISA71_RS00755	COG0604	alcohol dehydrogenase
ISA71_RS00760	COG0436	Aminotransferase
ISA71_RS00775	COG2011	ABC-type metal ion transport system permease component
ISA71_RS00790	COG0673	inositol 2-dehydrogenase activity
ISA71_RS00795	COG1349	DNA-binding transcription factor activity
ISA71_RS00805	COG0513	Belongs to the DEAD box helicase family
ISA71_RS00815	COG0589	response to stress
ISA71_RS00825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA71_RS00830	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISA71_RS00830	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISA71_RS00830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA71_RS00830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISA71_RS00835	COG3042	response to heat
ISA71_RS00840	COG3187	Heat shock protein
ISA71_RS00845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA71_RS00850	COG0586	Pfam SNARE associated Golgi protein
ISA71_RS00855	COG2911	Protein conserved in bacteria
ISA71_RS00865	COG3784	Protein of unknown function (DUF1318)
ISA71_RS00870	COG2207	Transcriptional regulator
ISA71_RS00875	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS00890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS00900	COG1126	abc transporter atp-binding protein
ISA71_RS00905	COG0583	DNA-binding transcription factor activity
ISA71_RS00910	COG2072	flavoprotein involved in K transport
ISA71_RS00945	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS00945	COG2030	dehydratase
ISA71_RS00950	COG3396	Phenylacetate-CoA oxygenase
ISA71_RS00955	COG3460	Phenylacetate-CoA oxygenase
ISA71_RS00960	COG3396	Phenylacetate-CoA oxygenase
ISA71_RS00965	COG2151	metal-sulfur cluster biosynthetic enzyme
ISA71_RS00970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA71_RS00975	COG1024	Enoyl-CoA hydratase
ISA71_RS00980	COG1024	Enoyl-CoA hydratase
ISA71_RS00985	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA71_RS00990	COG2050	protein possibly involved in aromatic compounds catabolism
ISA71_RS00995	COG0183	Belongs to the thiolase family
ISA71_RS01000	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISA71_RS01005	COG3327	negative regulation of DNA-templated transcription, initiation
ISA71_RS01010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA71_RS01025	COG1643	Atp-dependent helicase
ISA71_RS01030	COG4122	O-methyltransferase activity
ISA71_RS01055	COG0583	DNA-binding transcription factor activity
ISA71_RS01060	COG0667	Aldo Keto reductase
ISA71_RS01065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA71_RS01075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA71_RS01080	COG3138	arginine N-succinyltransferase
ISA71_RS01085	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS01090	COG3724	N-succinylarginine dihydrolase activity
ISA71_RS01095	COG2988	succinylglutamate desuccinylase activity
ISA71_RS01100	COG1113	amino acid transport
ISA71_RS01110	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA71_RS01120	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS01125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISA71_RS01130	COG0401	homolog of Blt101
ISA71_RS01135	COG5562	phage envelope protein
ISA71_RS01140	COG0425	Belongs to the sulfur carrier protein TusA family
ISA71_RS01145	COG2391	methyltransferase activity
ISA71_RS01170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISA71_RS01175	COG1263	PTS System
ISA71_RS01175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA71_RS01180	COG1609	Transcriptional regulator
ISA71_RS01185	COG5339	Protein conserved in bacteria
ISA71_RS01190	COG1482	cell wall glycoprotein biosynthetic process
ISA71_RS01195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA71_RS01195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA71_RS01200	COG0114	fumarate hydratase activity
ISA71_RS01210	COG2205	protein histidine kinase activity
ISA71_RS01220	COG0745	RESPONSE REGULATOR receiver
ISA71_RS01225	COG3136	membrane protein required for alginate biosynthesis
ISA71_RS01235	COG0531	amino acid
ISA71_RS01250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISA71_RS01255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISA71_RS01270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA71_RS01285	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISA71_RS01290	COG1473	amidohydrolase
ISA71_RS01300	COG0583	DNA-binding transcription factor activity
ISA71_RS01305	COG2840	Smr protein MutS2
ISA71_RS01310	COG1414	Transcriptional regulator
ISA71_RS01320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA71_RS01325	COG0183	Belongs to the thiolase family
ISA71_RS01335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISA71_RS01340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA71_RS01355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA71_RS01355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA71_RS01375	COG4565	transcriptional regulatory protein
ISA71_RS01380	COG3290	protein histidine kinase activity
ISA71_RS01405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA71_RS01415	COG0679	Auxin Efflux Carrier
ISA71_RS01445	COG0628	permease
ISA71_RS01465	COG3591	Belongs to the peptidase S1B family
ISA71_RS01475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISA71_RS01480	COG2814	Major facilitator Superfamily
ISA71_RS01485	COG0583	DNA-binding transcription factor activity
ISA71_RS01490	COG1940	carbohydrate kinase activity
ISA71_RS01495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISA71_RS01510	COG3302	dmso reductase anchor subunit
ISA71_RS01515	COG0437	4 iron, 4 sulfur cluster binding
ISA71_RS01520	COG0243	molybdopterin cofactor binding
ISA71_RS01535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA71_RS01550	COG2271	Major facilitator Superfamily
ISA71_RS01555	COG0246	Mannitol dehydrogenase
ISA71_RS01560	COG0589	response to stress
ISA71_RS01565	COG1802	Transcriptional regulator
ISA71_RS01570	COG4221	oxidoreductase activity
ISA71_RS01585	COG2207	Transcriptional regulator
ISA71_RS01590	COG2135	peptidase activity
ISA71_RS01605	COG2197	response regulator
ISA71_RS01625	COG0071	Belongs to the small heat shock protein (HSP20) family
ISA71_RS01630	COG1546	Belongs to the CinA family
ISA71_RS01635	COG2200	EAL domain
ISA71_RS01650	COG3708	Transcriptional regulator
ISA71_RS01650	COG2207	Transcriptional regulator
ISA71_RS01655	COG2610	gluconate transmembrane transporter activity
ISA71_RS01660	COG3622	Belongs to the hyi family
ISA71_RS01665	COG0235	Class ii aldolase
ISA71_RS01670	COG3395	kinase activity
ISA71_RS01675	COG2084	Dehydrogenase
ISA71_RS01680	COG1349	DNA-binding transcription factor activity
ISA71_RS01695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISA71_RS01700	COG2223	nitrite transmembrane transporter activity
ISA71_RS01735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISA71_RS01740	COG0683	leucine binding
ISA71_RS01770	COG2814	Major facilitator Superfamily
ISA71_RS01775	COG0697	spore germination
ISA71_RS01785	COG4977	sequence-specific DNA binding
ISA71_RS01815	COG2271	Major facilitator Superfamily
ISA71_RS01820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA71_RS01825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA71_RS01835	COG3395	kinase activity
ISA71_RS01840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA71_RS01845	COG1349	DNA-binding transcription factor activity
ISA71_RS01850	COG0039	L-malate dehydrogenase activity
ISA71_RS01860	COG0583	DNA-binding transcription factor activity
ISA71_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS01880	COG2199	diguanylate cyclase activity
ISA71_RS01950	COG0477	Major facilitator Superfamily
ISA71_RS01960	COG2070	2-Nitropropane dioxygenase
ISA71_RS01965	COG2011	ABC-type metal ion transport system permease component
ISA71_RS01985	COG4628	conserved protein (DUF2132)
ISA71_RS02000	COG2207	Transcriptional regulator
ISA71_RS02030	COG2233	PERMEase
ISA71_RS02035	COG3648	Uricase
ISA71_RS02035	COG3195	allantoin biosynthetic process
ISA71_RS02040	COG2351	hydroxyisourate hydrolase activity
ISA71_RS02045	COG1396	sequence-specific DNA binding
ISA71_RS02050	COG3550	peptidyl-serine autophosphorylation
ISA71_RS02055	COG1649	PFAM Uncharacterised BCR, COG1649
ISA71_RS02065	COG3188	usher protein
ISA71_RS02100	COG5001	Diguanylate cyclase
ISA71_RS02100	COG3300	MHYT domain
ISA71_RS02105	COG2819	hydrolase of the alpha beta superfamily
ISA71_RS02120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS02120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS02125	COG2814	Major facilitator Superfamily
ISA71_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA71_RS02135	COG1263	PTS System
ISA71_RS02140	COG2186	Transcriptional regulator
ISA71_RS02160	COG3835	regulator
ISA71_RS02165	COG1929	Belongs to the glycerate kinase type-1 family
ISA71_RS02210	COG0738	Major facilitator superfamily
ISA71_RS02215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA71_RS02220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA71_RS02225	COG1349	DNA-binding transcription factor activity
ISA71_RS02240	COG1349	DNA-binding transcription factor activity
ISA71_RS02265	COG3386	PFAM SMP-30 Gluconolaconase
ISA71_RS02270	COG0667	Aldo Keto reductase
ISA71_RS02275	COG0667	Aldo Keto reductase
ISA71_RS02285	COG0456	acetyltransferase
ISA71_RS02285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISA71_RS02310	COG1652	LysM domain
ISA71_RS02340	COG1609	Transcriptional regulator
ISA71_RS02350	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS02365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA71_RS02375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA71_RS02380	COG0583	DNA-binding transcription factor activity
ISA71_RS02400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS02405	COG1609	Transcriptional regulator
ISA71_RS02415	COG2223	nitrite transmembrane transporter activity
ISA71_RS02445	COG0477	Major facilitator Superfamily
ISA71_RS02450	COG4529	Protein conserved in bacteria
ISA71_RS02455	COG1902	pentaerythritol trinitrate reductase activity
ISA71_RS02465	COG0583	DNA-binding transcription factor activity
ISA71_RS02470	COG2070	2-Nitropropane dioxygenase
ISA71_RS02480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISA71_RS02490	COG0765	amino acid transport
ISA71_RS02535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA71_RS02560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA71_RS02575	COG2207	Transcriptional regulator
ISA71_RS02590	COG1335	isochorismatase
ISA71_RS02595	COG0406	alpha-ribazole phosphatase activity
ISA71_RS02635	COG1953	Uracil, thiamine, allantoin
ISA71_RS02640	COG0402	S-adenosylhomocysteine deaminase activity
ISA71_RS02645	COG3706	GGDEF domain
ISA71_RS02650	COG1609	Transcriptional regulator
ISA71_RS02660	COG0673	inositol 2-dehydrogenase activity
ISA71_RS02675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISA71_RS02680	COG1116	anion transmembrane transporter activity
ISA71_RS02685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA71_RS02690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA71_RS02695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA71_RS02700	COG0076	glutamate decarboxylase activity
ISA71_RS02720	COG2205	protein histidine kinase activity
ISA71_RS02730	COG0596	Alpha beta hydrolase
ISA71_RS02770	COG0519	Catalyzes the synthesis of GMP from XMP
ISA71_RS02770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISA71_RS02790	COG0583	DNA-binding transcription factor activity
ISA71_RS02800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA71_RS02805	COG1285	pathogenesis
ISA71_RS02810	COG2814	Major facilitator Superfamily
ISA71_RS02815	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA71_RS02820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS02845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS02855	COG0243	molybdopterin cofactor binding
ISA71_RS02860	COG3781	membrane
ISA71_RS02885	COG1764	response to oxidative stress
ISA71_RS02895	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA71_RS02905	COG2323	membrane
ISA71_RS02915	COG0366	Alpha amylase catalytic
ISA71_RS02925	COG3685	Protein conserved in bacteria
ISA71_RS02935	COG3729	General stress protein
ISA71_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS02980	COG0488	(ABC) transporter
ISA71_RS02995	COG1064	alcohol dehydrogenase
ISA71_RS03000	COG0747	negative chemotaxis
ISA71_RS03010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS03020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA71_RS03030	COG2814	Major facilitator Superfamily
ISA71_RS03040	COG2326	polyphosphate kinase activity
ISA71_RS03055	COG2864	formate dehydrogenase
ISA71_RS03060	COG0437	4 iron, 4 sulfur cluster binding
ISA71_RS03085	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ISA71_RS03095	COG3485	protocatechuate 3,4-dioxygenase
ISA71_RS03100	COG4829	muconolactone delta-isomerase
ISA71_RS03105	COG4948	Mandelate Racemase Muconate Lactonizing
ISA71_RS03110	COG1414	Transcriptional regulator
ISA71_RS03125	COG2223	nitrite transmembrane transporter activity
ISA71_RS03130	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA71_RS03135	COG1140	nitrate reductase beta subunit
ISA71_RS03140	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA71_RS03145	COG2181	nitrate reductase activity
ISA71_RS03150	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ISA71_RS03155	COG1178	ABC-type Fe3 transport system permease component
ISA71_RS03160	COG1840	ABC-type Fe3 transport system, periplasmic component
ISA71_RS03165	COG3842	ATPase activity
ISA71_RS03170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA71_RS03185	COG2211	Major facilitator Superfamily
ISA71_RS03210	COG0625	glutathione transferase activity
ISA71_RS03220	COG1126	abc transporter atp-binding protein
ISA71_RS03225	COG0765	amino acid transport
ISA71_RS03235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS03240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA71_RS03245	COG1473	amidohydrolase
ISA71_RS03250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA71_RS03255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA71_RS03280	COG4772	TonB-dependent receptor
ISA71_RS03285	COG1228	amidohydrolase
ISA71_RS03290	COG3691	Protein conserved in bacteria
ISA71_RS03305	COG2130	NADP-dependent
ISA71_RS03315	COG1247	-acetyltransferase
ISA71_RS03320	COG3238	Protein conserved in bacteria
ISA71_RS03330	COG0747	negative chemotaxis
ISA71_RS03335	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS03370	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS03375	COG1177	transmembrane transport
ISA71_RS03380	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA71_RS03385	COG3842	ATPase activity
ISA71_RS03390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA71_RS03395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA71_RS03400	COG1271	oxidase subunit
ISA71_RS03405	COG1294	oxidase, subunit
ISA71_RS03425	COG0826	peptidase U32
ISA71_RS03435	COG1396	sequence-specific DNA binding
ISA71_RS03440	COG3135	benzoate transporter
ISA71_RS03445	COG2207	Transcriptional regulator
ISA71_RS03445	COG3708	Transcriptional regulator
ISA71_RS03460	COG0500	methyltransferase
ISA71_RS03465	COG1275	C4-dicarboxylate transporter malic acid transport protein
ISA71_RS03470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA71_RS03475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA71_RS03490	COG2272	Belongs to the type-B carboxylesterase lipase family
ISA71_RS03495	COG5383	Protein conserved in bacteria
ISA71_RS03500	COG3485	protocatechuate 3,4-dioxygenase
ISA71_RS03505	COG3485	protocatechuate 3,4-dioxygenase
ISA71_RS03510	COG0583	DNA-binding transcription factor activity
ISA71_RS03530	COG3038	cytochrome b561
ISA71_RS03550	COG2814	Major facilitator Superfamily
ISA71_RS03560	COG0673	inositol 2-dehydrogenase activity
ISA71_RS03570	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS03605	COG4659	FMN binding
ISA71_RS03615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISA71_RS03625	COG0625	glutathione transferase activity
ISA71_RS03630	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISA71_RS03645	COG3895	Periplasmic Protein
ISA71_RS03660	COG3706	GGDEF domain
ISA71_RS03675	COG1566	PFAM secretion protein HlyD family protein
ISA71_RS03680	COG1289	transmembrane transporter activity
ISA71_RS03685	COG2032	superoxide dismutase activity
ISA71_RS03690	COG4989	oxidoreductase activity
ISA71_RS03695	COG3313	Fe-S protein
ISA71_RS03700	COG1309	transcriptional regulator
ISA71_RS03705	COG1902	pentaerythritol trinitrate reductase activity
ISA71_RS03710	COG0346	lactoylglutathione lyase activity
ISA71_RS03720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISA71_RS03725	COG0791	NLP P60 protein
ISA71_RS03740	COG2814	Major facilitator Superfamily
ISA71_RS03755	COG0583	DNA-binding transcription factor activity
ISA71_RS03760	COG2814	Major facilitator Superfamily
ISA71_RS03765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA71_RS03770	COG0307	riboflavin synthase, alpha
ISA71_RS03825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISA71_RS03860	COG1349	DNA-binding transcription factor activity
ISA71_RS03865	COG0346	lactoylglutathione lyase activity
ISA71_RS03890	COG0444	Belongs to the ABC transporter superfamily
ISA71_RS03895	COG4608	Belongs to the ABC transporter superfamily
ISA71_RS03925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA71_RS03935	COG1082	Xylose isomerase domain protein TIM barrel
ISA71_RS03940	COG2814	Major facilitator Superfamily
ISA71_RS03970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS03975	COG2205	protein histidine kinase activity
ISA71_RS03980	COG0745	RESPONSE REGULATOR receiver
ISA71_RS03990	COG2200	EAL domain
ISA71_RS04040	COG0402	S-adenosylhomocysteine deaminase activity
ISA71_RS04065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA71_RS04070	COG0277	FAD linked oxidase domain protein
ISA71_RS04095	COG0583	DNA-binding transcription factor activity
ISA71_RS04105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA71_RS04115	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA71_RS04120	COG2610	gluconate transmembrane transporter activity
ISA71_RS04125	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS04165	COG0656	L-ascorbic acid biosynthetic process
ISA71_RS04170	COG2207	Transcriptional regulator
ISA71_RS04185	COG3088	subunit of a heme lyase
ISA71_RS04185	COG4235	cytochrome complex assembly
ISA71_RS04190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA71_RS04195	COG1138	Cytochrome C-type biogenesis protein
ISA71_RS04210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA71_RS04215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA71_RS04220	COG4133	protoheme IX ABC transporter activity
ISA71_RS04250	COG3157	Type VI secretion system effector, Hcp
ISA71_RS04255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA71_RS04260	COG1518	maintenance of DNA repeat elements
ISA71_RS04270	COG1857	crispr-associated protein
ISA71_RS04300	COG1175	transmembrane transport
ISA71_RS04310	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ISA71_RS04315	COG3383	formate dehydrogenase (NAD+) activity
ISA71_RS04355	COG1126	abc transporter atp-binding protein
ISA71_RS04360	COG0765	amino acid transport
ISA71_RS04380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS04385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS04390	COG1120	ATPase activity
ISA71_RS04395	COG4774	siderophore transport
ISA71_RS04400	COG1116	anion transmembrane transporter activity
ISA71_RS04405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA71_RS04425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA71_RS04430	COG0583	DNA-binding transcription factor activity
ISA71_RS04450	COG2814	Major facilitator Superfamily
ISA71_RS04485	COG1414	Transcriptional regulator
ISA71_RS04490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA71_RS04495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS04500	COG1120	ATPase activity
ISA71_RS04510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA71_RS04515	COG2271	Major facilitator Superfamily
ISA71_RS04520	COG1082	Xylose isomerase domain protein TIM barrel
ISA71_RS04520	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ISA71_RS04525	COG1309	transcriptional regulator
ISA71_RS04555	COG1376	ErfK ybiS ycfS ynhG family protein
ISA71_RS04570	COG0719	Fe-S assembly protein
ISA71_RS04575	COG0396	ATPase activity
ISA71_RS04580	COG0719	Fe-S assembly protein
ISA71_RS04585	COG0316	Belongs to the HesB IscA family
ISA71_RS04605	COG1309	transcriptional regulator
ISA71_RS04610	COG1304	FMN binding
ISA71_RS04635	COG0583	DNA-binding transcription factor activity
ISA71_RS04645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS04650	COG1120	ATPase activity
ISA71_RS04675	COG2261	transglycosylase associated protein
ISA71_RS04680	COG2050	protein possibly involved in aromatic compounds catabolism
ISA71_RS04685	COG0247	lactate metabolic process
ISA71_RS04685	COG0277	FAD linked oxidase domain protein
ISA71_RS04690	COG0628	permease
ISA71_RS04700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA71_RS04700	COG0574	Belongs to the PEP-utilizing enzyme family
ISA71_RS04715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA71_RS04720	COG4256	Hemin uptake protein
ISA71_RS04730	COG0791	NLP P60 protein
ISA71_RS04740	COG0386	Belongs to the glutathione peroxidase family
ISA71_RS04760	COG0583	DNA-binding transcription factor activity
ISA71_RS04780	COG0072	phenylalanine-tRNA ligase activity
ISA71_RS04780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISA71_RS04820	COG3137	Salt-induced outer membrane protein
ISA71_RS04825	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA71_RS04835	COG3001	Fructosamine kinase
ISA71_RS04845	COG2350	Protein conserved in bacteria
ISA71_RS04855	COG2353	YceI-like domain
ISA71_RS04875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA71_RS04885	COG0444	Belongs to the ABC transporter superfamily
ISA71_RS04890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS04895	COG0601	transmembrane transport
ISA71_RS04900	COG4166	transmembrane transport
ISA71_RS04905	COG2095	MarC family integral membrane protein
ISA71_RS04915	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS04915	COG1454	alcohol dehydrogenase
ISA71_RS04920	COG1435	thymidine kinase activity
ISA71_RS04930	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA71_RS04935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISA71_RS04940	COG0745	RESPONSE REGULATOR receiver
ISA71_RS04945	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISA71_RS04955	COG0788	formyltetrahydrofolate deformylase activity
ISA71_RS04990	COG1522	sequence-specific DNA binding
ISA71_RS05000	COG2181	nitrate reductase activity
ISA71_RS05005	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA71_RS05010	COG1140	nitrate reductase beta subunit
ISA71_RS05015	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA71_RS05025	COG2223	nitrite transmembrane transporter activity
ISA71_RS05030	COG3850	Histidine kinase
ISA71_RS05035	COG2197	response regulator
ISA71_RS05040	COG4932	domain protein
ISA71_RS05045	COG0243	molybdopterin cofactor binding
ISA71_RS05050	COG2146	nitrite reductase [NAD(P)H] activity
ISA71_RS05050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA71_RS05055	COG1116	anion transmembrane transporter activity
ISA71_RS05065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA71_RS05070	COG3707	response regulator
ISA71_RS05075	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISA71_RS05085	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ISA71_RS05090	COG4572	Cation transport regulator
ISA71_RS05095	COG0387	Pfam Sodium calcium exchanger
ISA71_RS05115	COG2890	protein-(glutamine-N5) methyltransferase activity
ISA71_RS05145	COG0659	secondary active sulfate transmembrane transporter activity
ISA71_RS05165	COG0012	GTP binding
ISA71_RS05260	COG2885	chlorophyll binding
ISA71_RS05280	COG3122	Protein conserved in bacteria
ISA71_RS05295	COG0583	DNA-binding transcription factor activity
ISA71_RS05325	COG0583	DNA-binding transcription factor activity
ISA71_RS05360	COG1882	Formate acetyltransferase
ISA71_RS05375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA71_RS05380	COG0583	DNA-binding transcription factor activity
ISA71_RS05420	COG2308	Evidence 4 Homologs of previously reported genes of
ISA71_RS05435	COG4774	siderophore transport
ISA71_RS05445	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISA71_RS05470	COG2719	SpoVR family
ISA71_RS05500	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA71_RS05515	COG2894	cell division
ISA71_RS05525	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISA71_RS05535	COG3065	identical protein binding
ISA71_RS05545	COG1199	ATP-dependent helicase activity
ISA71_RS05550	COG0251	oxidation-reduction process
ISA71_RS05570	COG1760	l-serine dehydratase
ISA71_RS05575	COG2200	EAL domain
ISA71_RS05580	COG1253	flavin adenine dinucleotide binding
ISA71_RS05585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA71_RS05585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS05590	COG3715	PTS system
ISA71_RS05595	COG3716	PTS system mannose fructose sorbose family IID component
ISA71_RS05610	COG2226	methyltransferase
ISA71_RS05615	COG0768	penicillin binding
ISA71_RS05645	COG1414	Transcriptional regulator
ISA71_RS05650	COG2814	Major facilitator Superfamily
ISA71_RS05670	COG1956	GAF domain-containing protein
ISA71_RS05675	COG2995	paraquat-inducible protein a
ISA71_RS05680	COG3008	intermembrane lipid transfer
ISA71_RS05705	COG2990	Protein conserved in bacteria
ISA71_RS05720	COG1276	copper resistance
ISA71_RS05725	COG2372	response to copper ion
ISA71_RS05735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA71_RS05740	COG1770	oligopeptidase
ISA71_RS05745	COG2979	Protein of unknown function (DUF533)
ISA71_RS05750	COG3141	response to X-ray
ISA71_RS05760	COG0800	Aldolase
ISA71_RS05765	COG0129	dihydroxy-acid dehydratase activity
ISA71_RS05770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISA71_RS05780	COG1737	Transcriptional regulator
ISA71_RS05790	COG1560	Kdo2-lipid A biosynthetic process
ISA71_RS05795	COG0739	heme binding
ISA71_RS05800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISA71_RS05810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA71_RS05835	COG0494	nUDIX hydrolase
ISA71_RS05845	COG1335	isochorismatase
ISA71_RS05850	COG1801	Protein of unknown function DUF72
ISA71_RS05855	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISA71_RS05875	COG3102	Protein conserved in bacteria
ISA71_RS05885	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISA71_RS05910	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS05920	COG1879	ABC-type sugar transport system periplasmic component
ISA71_RS05930	COG1528	Iron-storage protein
ISA71_RS05940	COG2211	Major facilitator Superfamily
ISA71_RS05950	COG0477	Major facilitator Superfamily
ISA71_RS05965	COG1528	Iron-storage protein
ISA71_RS05975	COG0814	amino acid
ISA71_RS05980	COG3012	SEC-C Motif Domain Protein
ISA71_RS05980	COG3318	Belongs to the UPF0149 family
ISA71_RS06000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ISA71_RS06115	COG4626	Terminase
ISA71_RS06115	COG1802	Transcriptional regulator
ISA71_RS06185	COG1403	HNH endonuclease
ISA71_RS06190	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ISA71_RS06285	COG2197	response regulator
ISA71_RS06295	COG2197	response regulator
ISA71_RS06300	COG1126	abc transporter atp-binding protein
ISA71_RS06305	COG0765	amino acid transport
ISA71_RS06315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS06320	COG0366	Alpha amylase catalytic
ISA71_RS06350	COG2354	Protein conserved in bacteria
ISA71_RS06355	COG0697	spore germination
ISA71_RS06360	COG3727	T/G mismatch-specific endonuclease activity
ISA71_RS06365	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISA71_RS06370	COG1418	mRNA catabolic process
ISA71_RS06380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA71_RS06400	COG0251	oxidation-reduction process
ISA71_RS06430	COG0025	NhaP-type Na H and K H
ISA71_RS06435	COG1309	transcriptional regulator
ISA71_RS06440	COG0604	alcohol dehydrogenase
ISA71_RS06460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISA71_RS06485	COG2264	protein methyltransferase activity
ISA71_RS06515	COG2994	toxin metabolic process
ISA71_RS06550	COG0582	viral genome integration into host DNA
ISA71_RS06560	COG0534	Mate efflux family protein
ISA71_RS06575	COG3706	GGDEF domain
ISA71_RS06600	COG3615	Tellurite resistance protein tehB
ISA71_RS06610	COG5001	Diguanylate cyclase
ISA71_RS06610	COG3300	MHYT domain
ISA71_RS06620	COG0477	Major facilitator Superfamily
ISA71_RS06625	COG0095	Lipoate-protein ligase
ISA71_RS06630	COG0583	DNA-binding transcription factor activity
ISA71_RS06635	COG1942	4-Oxalocrotonate Tautomerase
ISA71_RS06645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ISA71_RS06665	COG1289	transmembrane transporter activity
ISA71_RS06680	COG2925	Exonuclease
ISA71_RS06685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISA71_RS06690	COG0640	Transcriptional regulator
ISA71_RS06695	COG0531	amino acid
ISA71_RS06705	COG0583	DNA-binding transcription factor activity
ISA71_RS06710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA71_RS06740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISA71_RS06760	COG1215	transferase activity, transferring glycosyl groups
ISA71_RS06765	COG0438	transferase activity, transferring glycosyl groups
ISA71_RS06840	COG0778	Nitroreductase
ISA71_RS06875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISA71_RS06905	COG1253	flavin adenine dinucleotide binding
ISA71_RS06910	COG2982	Protein involved in outer membrane biogenesis
ISA71_RS06925	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISA71_RS06930	COG0443	Heat shock 70 kDa protein
ISA71_RS06935	COG5002	protein histidine kinase activity
ISA71_RS06955	COG1301	dicarboxylic acid transport
ISA71_RS06980	COG2205	protein histidine kinase activity
ISA71_RS06985	COG0745	RESPONSE REGULATOR receiver
ISA71_RS06990	COG0826	peptidase U32
ISA71_RS07000	COG4608	Belongs to the ABC transporter superfamily
ISA71_RS07005	COG0444	Belongs to the ABC transporter superfamily
ISA71_RS07010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS07015	COG0601	transmembrane transport
ISA71_RS07020	COG0747	negative chemotaxis
ISA71_RS07025	COG4948	Mandelate Racemase Muconate Lactonizing
ISA71_RS07030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA71_RS07040	COG1070	Carbohydrate kinase
ISA71_RS07075	COG1830	Aldolase
ISA71_RS07080	COG0351	phosphomethylpyrimidine kinase
ISA71_RS07095	COG0583	DNA-binding transcription factor activity
ISA71_RS07105	COG2252	PERMEase
ISA71_RS07110	COG0583	DNA-binding transcription factor activity
ISA71_RS07115	COG5455	response to cobalt ion
ISA71_RS07135	COG4807	Protein conserved in bacteria
ISA71_RS07145	COG3275	phosphorelay sensor kinase activity
ISA71_RS07155	COG1174	glycine betaine transport
ISA71_RS07160	COG1125	glycine betaine transport
ISA71_RS07165	COG1174	glycine betaine transport
ISA71_RS07170	COG1732	Glycine betaine
ISA71_RS07175	COG1472	Belongs to the glycosyl hydrolase 3 family
ISA71_RS07180	COG0277	FAD linked oxidase domain protein
ISA71_RS07190	COG1686	Belongs to the peptidase S11 family
ISA71_RS07200	COG0586	Pfam SNARE associated Golgi protein
ISA71_RS07205	COG1538	Outer membrane efflux protein
ISA71_RS07210	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS07225	COG3659	wide pore channel activity
ISA71_RS07230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA71_RS07240	COG1346	cytolysis
ISA71_RS07250	COG2949	membrane
ISA71_RS07260	COG1129	ABC transporter
ISA71_RS07275	COG2311	Membrane
ISA71_RS07290	COG4771	TonB-dependent receptor
ISA71_RS07295	COG0833	amino acid
ISA71_RS07300	COG0583	DNA-binding transcription factor activity
ISA71_RS07305	COG2855	membrane
ISA71_RS07315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA71_RS07315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA71_RS07315	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISA71_RS07320	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA71_RS07325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS07325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS07345	COG1312	Catalyzes the dehydration of D-mannonate
ISA71_RS07350	COG0246	Mannitol dehydrogenase
ISA71_RS07355	COG0523	cobalamin synthesis protein
ISA71_RS07360	COG0671	phosphoesterase, PA-phosphatase related
ISA71_RS07365	COG0791	NLP P60 protein
ISA71_RS07370	COG2200	EAL domain
ISA71_RS07375	COG4166	transmembrane transport
ISA71_RS07380	COG4174	ABC transporter (Permease)
ISA71_RS07385	COG4239	(ABC) transporter, permease
ISA71_RS07390	COG4172	Belongs to the ABC transporter superfamily
ISA71_RS07400	COG2814	Major facilitator Superfamily
ISA71_RS07405	COG1187	pseudouridine synthase activity
ISA71_RS07410	COG1061	Type III restriction enzyme res subunit
ISA71_RS07430	COG0494	nUDIX hydrolase
ISA71_RS07435	COG1349	DNA-binding transcription factor activity
ISA71_RS07460	COG0628	permease
ISA71_RS07475	COG0659	secondary active sulfate transmembrane transporter activity
ISA71_RS07480	COG2239	Acts as a magnesium transporter
ISA71_RS07485	COG4615	Cyclic peptide transporter
ISA71_RS07490	COG3145	DNA-N1-methyladenine dioxygenase activity
ISA71_RS07495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA71_RS07495	COG2169	Transcriptional regulator
ISA71_RS07510	COG2198	Histidine kinase
ISA71_RS07510	COG0642	Histidine kinase
ISA71_RS07520	COG0784	Response regulator, receiver
ISA71_RS07520	COG2205	protein histidine kinase activity
ISA71_RS07545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA71_RS07550	COG0584	glycerophosphoryl diester phosphodiesterase
ISA71_RS07555	COG2271	Major facilitator Superfamily
ISA71_RS07560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA71_RS07570	COG0247	lactate metabolic process
ISA71_RS07580	COG2271	Major facilitator Superfamily
ISA71_RS07590	COG1414	Transcriptional regulator
ISA71_RS07605	COG5464	transposase or invertase
ISA71_RS07615	COG0318	PFAM AMP-dependent synthetase and ligase
ISA71_RS07640	COG1169	isochorismate synthase
ISA71_RS07645	COG2153	protein acetylation
ISA71_RS07660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA71_RS07665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISA71_RS07675	COG0839	Belongs to the complex I subunit 6 family
ISA71_RS07720	COG0583	DNA-binding transcription factor activity
ISA71_RS07725	COG0436	Aminotransferase
ISA71_RS07735	COG0490	domain, Protein
ISA71_RS07735	COG0471	metal ion transport
ISA71_RS07740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA71_RS07760	COG0857	belongs to the CobB CobQ family
ISA71_RS07760	COG0280	phosphate acetyltransferase
ISA71_RS07765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISA71_RS07770	COG0622	Phosphoesterase
ISA71_RS07775	COG0625	glutathione transferase activity
ISA71_RS07780	COG0625	glutathione transferase activity
ISA71_RS07785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA71_RS07790	COG1090	epimerase
ISA71_RS07805	COG4598	ABC transporter
ISA71_RS07810	COG4160	amino acid transport
ISA71_RS07835	COG0163	prenyltransferase activity
ISA71_RS07840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISA71_RS07845	COG1286	toxin biosynthetic process
ISA71_RS07850	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISA71_RS07855	COG0285	dihydrofolate synthase activity
ISA71_RS07865	COG0586	Pfam SNARE associated Golgi protein
ISA71_RS07875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA71_RS07895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA71_RS07910	COG3101	peptidyl-lysine hydroxylation
ISA71_RS07915	COG0730	response to heat
ISA71_RS07940	COG2062	phosphohistidine phosphatase, SixA
ISA71_RS07955	COG3691	Protein conserved in bacteria
ISA71_RS07965	COG2853	Lipoprotein
ISA71_RS07970	COG2116	formate transmembrane transporter activity
ISA71_RS07990	COG0583	DNA-binding transcription factor activity
ISA71_RS07995	COG0590	tRNA wobble adenosine to inosine editing
ISA71_RS08000	COG2807	transmembrane transport
ISA71_RS08010	COG0436	Aminotransferase
ISA71_RS08025	COG3275	phosphorelay sensor kinase activity
ISA71_RS08030	COG3279	Response regulator of the LytR AlgR family
ISA71_RS08045	COG3961	Belongs to the TPP enzyme family
ISA71_RS08050	COG0667	Aldo Keto reductase
ISA71_RS08065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA71_RS08070	COG2199	diguanylate cyclase activity
ISA71_RS08070	COG2200	EAL domain
ISA71_RS08085	COG3415	Transposase
ISA71_RS08090	COG3415	Transposase
ISA71_RS08125	COG0583	DNA-binding transcription factor activity
ISA71_RS08130	COG0385	Bile acid
ISA71_RS08135	COG3530	Putative quorum-sensing-regulated virulence factor
ISA71_RS08155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISA71_RS08190	COG4319	ketosteroid isomerase
ISA71_RS08200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISA71_RS08205	COG4208	sulfate ABC transporter
ISA71_RS08210	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISA71_RS08215	COG4150	thiosulfate binding
ISA71_RS08225	COG2837	iron assimilation
ISA71_RS08245	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA71_RS08335	COG4810	utilization protein
ISA71_RS08345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA71_RS08350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA71_RS08355	COG5342	invasion associated locus B
ISA71_RS08365	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA71_RS08365	COG0493	'glutamate synthase
ISA71_RS08370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA71_RS08380	COG1393	Belongs to the ArsC family
ISA71_RS08395	COG0400	carboxylic ester hydrolase activity
ISA71_RS08400	COG1444	tRNA N-acetyltransferase activity
ISA71_RS08405	COG2321	neutral zinc metallopeptidase
ISA71_RS08415	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISA71_RS08425	COG2716	regulation of RNA biosynthetic process
ISA71_RS08430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISA71_RS08435	COG0628	permease
ISA71_RS08445	COG4783	chaperone-mediated protein folding
ISA71_RS08450	COG1393	Belongs to the ArsC family
ISA71_RS08465	COG2233	PERMEase
ISA71_RS08475	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS08490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISA71_RS08525	COG0641	radical SAM
ISA71_RS08530	COG3119	arylsulfatase activity
ISA71_RS08540	COG0517	IMP dehydrogenase activity
ISA71_RS08540	COG0516	GMP reductase activity
ISA71_RS08550	COG1645	bacterial-type flagellum-dependent swarming motility
ISA71_RS08570	COG2976	Protein conserved in bacteria
ISA71_RS08600	COG4953	penicillin-binding protein 1C
ISA71_RS08605	COG2373	Large extracellular alpha-helical protein
ISA71_RS08610	COG2897	thiosulfate sulfurtransferase activity
ISA71_RS08630	COG2975	iron-sulfur cluster assembly
ISA71_RS08635	COG0633	Ferredoxin
ISA71_RS08655	COG0822	iron-sulfur transferase activity
ISA71_RS08685	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA71_RS08690	COG3683	transport system, periplasmic component
ISA71_RS08695	COG3711	transcriptional antiterminator
ISA71_RS08700	COG2814	Major facilitator Superfamily
ISA71_RS08705	COG2017	converts alpha-aldose to the beta-anomer
ISA71_RS08710	COG0477	Major facilitator Superfamily
ISA71_RS08710	COG2814	Major facilitator Superfamily
ISA71_RS08715	COG0457	Tetratricopeptide repeat
ISA71_RS08720	COG1940	carbohydrate kinase activity
ISA71_RS08725	COG2259	Doxx family
ISA71_RS08735	COG1017	nitric oxide dioxygenase activity
ISA71_RS08735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA71_RS08740	COG0347	Belongs to the P(II) protein family
ISA71_RS08745	COG2204	response regulator
ISA71_RS08750	COG3170	Tfp pilus assembly protein FimV
ISA71_RS08755	COG2205	protein histidine kinase activity
ISA71_RS08760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISA71_RS08760	COG0047	phosphoribosylformylglycinamidine synthase activity
ISA71_RS08775	COG0560	Phosphoserine phosphatase
ISA71_RS08780	COG1737	Transcriptional regulator
ISA71_RS08785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA71_RS08795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISA71_RS08815	COG0681	Belongs to the peptidase S26 family
ISA71_RS08825	COG3086	response to oxidative stress
ISA71_RS08830	COG3026	antisigma factor binding
ISA71_RS08835	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ISA71_RS08850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISA71_RS08860	COG0513	Belongs to the DEAD box helicase family
ISA71_RS08875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA71_RS08880	COG3118	belongs to the thioredoxin family
ISA71_RS08885	COG3148	PFAM DTW domain containing protein
ISA71_RS08895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA71_RS08900	COG5544	Lipoprotein
ISA71_RS08905	COG0477	Major facilitator Superfamily
ISA71_RS08930	COG0542	response to heat
ISA71_RS08945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA71_RS08950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA71_RS08960	COG1605	Chorismate mutase
ISA71_RS08960	COG0077	Prephenate dehydratase
ISA71_RS08970	COG0287	Prephenate dehydrogenase
ISA71_RS08970	COG1605	Chorismate mutase
ISA71_RS08975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA71_RS08985	COG2199	diguanylate cyclase activity
ISA71_RS08990	COG2885	chlorophyll binding
ISA71_RS09025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISA71_RS09030	COG4137	Cytochrome C assembly protein
ISA71_RS09035	COG4536	flavin adenine dinucleotide binding
ISA71_RS09050	COG0497	DNA recombination
ISA71_RS09065	COG2867	negative regulation of translational initiation
ISA71_RS09095	COG2207	Transcriptional regulator
ISA71_RS09095	COG3708	Transcriptional regulator
ISA71_RS09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS09135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS09145	COG0235	Class ii aldolase
ISA71_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS09170	COG2197	response regulator
ISA71_RS09175	COG3539	Fimbrial protein
ISA71_RS09185	COG3188	usher protein
ISA71_RS09205	COG3121	Chaperone
ISA71_RS09210	COG3539	Fimbrial protein
ISA71_RS09220	COG3284	Transcriptional regulator
ISA71_RS09225	COG0583	DNA-binding transcription factor activity
ISA71_RS09235	COG0640	Transcriptional regulator
ISA71_RS09240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA71_RS09255	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA71_RS09270	COG4575	ribosome binding
ISA71_RS09275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA71_RS09280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA71_RS09285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA71_RS09295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISA71_RS09310	COG4176	ABC-type proline glycine betaine transport system permease component
ISA71_RS09320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISA71_RS09330	COG1846	Transcriptional regulator
ISA71_RS09335	COG1566	PFAM secretion protein HlyD family protein
ISA71_RS09340	COG2814	Major facilitator Superfamily
ISA71_RS09345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISA71_RS09365	COG1238	metal cluster binding
ISA71_RS09370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA71_RS09375	COG2823	Periplasmic or secreted lipoprotein
ISA71_RS09405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISA71_RS09425	COG1546	Belongs to the CinA family
ISA71_RS09435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA71_RS09440	COG1121	(ABC) transporter
ISA71_RS09445	COG2951	lytic endotransglycosylase activity
ISA71_RS09450	COG3730	PTS system glucitol sorbitol-specific
ISA71_RS09455	COG3732	PTS system glucitol sorbitol-specific
ISA71_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS09470	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS09475	COG1349	DNA-binding transcription factor activity
ISA71_RS09500	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA71_RS09505	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ISA71_RS09510	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA71_RS09515	COG1609	Transcriptional regulator
ISA71_RS09520	COG1263	PTS System
ISA71_RS09520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA71_RS09525	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS09535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISA71_RS09545	COG3260	NADH ubiquinone oxidoreductase 20
ISA71_RS09550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA71_RS09555	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ISA71_RS09555	COG3261	NADH dehydrogenase
ISA71_RS09560	COG0650	Formate hydrogenlyase subunit 4
ISA71_RS09565	COG0651	ATP synthesis coupled electron transport
ISA71_RS09570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA71_RS09585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISA71_RS09590	COG0298	carbon dioxide binding
ISA71_RS09595	COG0409	Hydrogenase expression formation protein
ISA71_RS09600	COG0309	Hydrogenase expression formation protein (HypE)
ISA71_RS09610	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS09620	COG4580	involved in the transport of maltose and maltodextrins
ISA71_RS09625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS09630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS09635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS09640	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA71_RS09645	COG1940	carbohydrate kinase activity
ISA71_RS09650	COG1609	Transcriptional regulator
ISA71_RS09660	COG1121	(ABC) transporter
ISA71_RS09665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA71_RS09670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA71_RS09685	COG0679	Auxin Efflux Carrier
ISA71_RS09705	COG3720	iron ion transport
ISA71_RS09710	COG4558	Periplasmic binding protein
ISA71_RS09715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS09740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA71_RS09745	COG0163	prenyltransferase activity
ISA71_RS09770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA71_RS09775	COG1388	LysM domain
ISA71_RS09775	COG4942	peptidase
ISA71_RS09835	COG2234	aminopeptidase activity
ISA71_RS09855	COG0720	synthase
ISA71_RS09860	COG0602	queuosine metabolic process
ISA71_RS09880	COG3956	TIGRFAM MazG family protein
ISA71_RS09885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA71_RS09895	COG2205	protein histidine kinase activity
ISA71_RS09895	COG3437	response regulator, receiver
ISA71_RS09895	COG3850	Histidine kinase
ISA71_RS09895	COG4999	Histidine kinase
ISA71_RS09900	COG1929	Belongs to the glycerate kinase type-1 family
ISA71_RS09905	COG4948	Mandelate Racemase Muconate Lactonizing
ISA71_RS09910	COG4948	Mandelate Racemase Muconate Lactonizing
ISA71_RS09915	COG2271	Major facilitator Superfamily
ISA71_RS09920	COG0716	FMN binding
ISA71_RS09925	COG0564	pseudouridine synthase activity
ISA71_RS09930	COG3098	single-species biofilm formation
ISA71_RS09945	COG1611	Belongs to the LOG family
ISA71_RS09950	COG0814	amino acid
ISA71_RS09955	COG1760	l-serine dehydratase
ISA71_RS09960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA71_RS09970	COG0477	Major facilitator Superfamily
ISA71_RS09975	COG1464	Belongs to the NlpA lipoprotein family
ISA71_RS09980	COG2011	ABC-type metal ion transport system permease component
ISA71_RS09985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISA71_RS10000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA71_RS10020	COG1454	alcohol dehydrogenase
ISA71_RS10025	COG0235	Class ii aldolase
ISA71_RS10030	COG0738	Major facilitator superfamily
ISA71_RS10050	COG1349	DNA-binding transcription factor activity
ISA71_RS10060	COG2363	Small membrane protein
ISA71_RS10065	COG0583	DNA-binding transcription factor activity
ISA71_RS10075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISA71_RS10080	COG2166	iron-sulfur cluster assembly
ISA71_RS10085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISA71_RS10090	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISA71_RS10255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ISA71_RS10285	COG1454	alcohol dehydrogenase
ISA71_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS10290	COG4656	Part of a membrane complex involved in electron transport
ISA71_RS10320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISA71_RS10325	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA71_RS10330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISA71_RS10330	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISA71_RS10340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISA71_RS10345	COG1074	ATP-dependent DNA helicase activity
ISA71_RS10350	COG1025	Belongs to the peptidase M16 family
ISA71_RS10355	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISA71_RS10360	COG4967	type IV pilus modification protein PilV
ISA71_RS10370	COG4795	General secretion pathway protein
ISA71_RS10375	COG2165	general secretion pathway protein
ISA71_RS10410	COG0861	Integral membrane protein TerC family
ISA71_RS10420	COG0667	Aldo Keto reductase
ISA71_RS10440	COG1609	Transcriptional regulator
ISA71_RS10450	COG2186	Transcriptional regulator
ISA71_RS10455	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS10460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS10465	COG1609	Transcriptional regulator
ISA71_RS10475	COG0583	DNA-binding transcription factor activity
ISA71_RS10480	COG1794	racemase activity, acting on amino acids and derivatives
ISA71_RS10485	COG1917	Cupin 2, conserved barrel domain protein
ISA71_RS10490	COG1175	transmembrane transport
ISA71_RS10495	COG0395	ABC-type sugar transport system, permease component
ISA71_RS10500	COG3842	ATPase activity
ISA71_RS10535	COG2814	Major facilitator Superfamily
ISA71_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS10545	COG0823	Involved in the tonB-independent uptake of proteins
ISA71_RS10555	COG0183	Belongs to the thiolase family
ISA71_RS10570	COG0814	amino acid
ISA71_RS10575	COG0667	Aldo Keto reductase
ISA71_RS10625	COG0697	spore germination
ISA71_RS10630	COG1846	Transcriptional regulator
ISA71_RS10635	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA71_RS10640	COG0582	viral genome integration into host DNA
ISA71_RS10645	COG4974	Belongs to the 'phage' integrase family
ISA71_RS10655	COG3539	Fimbrial protein
ISA71_RS10660	COG3121	Chaperone
ISA71_RS10665	COG3188	usher protein
ISA71_RS10670	COG3539	Fimbrial protein
ISA71_RS10675	COG3539	Fimbrial protein
ISA71_RS10680	COG3539	Fimbrial protein
ISA71_RS10690	COG2388	GCN5-related N-acetyl-transferase
ISA71_RS10695	COG3592	Divergent 4Fe-4S mono-cluster
ISA71_RS10710	COG1289	transmembrane transporter activity
ISA71_RS10715	COG1538	Outer membrane efflux protein
ISA71_RS10730	COG1393	Belongs to the ArsC family
ISA71_RS10735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA71_RS10775	COG0667	Aldo Keto reductase
ISA71_RS10790	COG2200	EAL domain
ISA71_RS10815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS10815	COG2198	Histidine kinase
ISA71_RS10815	COG0784	Response regulator, receiver
ISA71_RS10815	COG2205	protein histidine kinase activity
ISA71_RS10820	COG2197	response regulator
ISA71_RS10825	COG1566	PFAM secretion protein HlyD family protein
ISA71_RS10830	COG0477	Major facilitator Superfamily
ISA71_RS10845	COG0004	ammonium transporteR
ISA71_RS10850	COG0831	urea catabolic process
ISA71_RS10855	COG0832	Belongs to the urease beta subunit family
ISA71_RS10875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISA71_RS10885	COG4413	Urea transporter
ISA71_RS10895	COG0601	transmembrane transport
ISA71_RS10900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS10940	COG3121	Chaperone
ISA71_RS10945	COG3121	Chaperone
ISA71_RS10960	COG3121	Chaperone
ISA71_RS10970	COG2197	response regulator
ISA71_RS10975	COG0784	Response regulator, receiver
ISA71_RS10975	COG2205	protein histidine kinase activity
ISA71_RS10975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS10975	COG2198	Histidine kinase
ISA71_RS10985	COG2197	response regulator
ISA71_RS11010	COG2814	Major facilitator Superfamily
ISA71_RS11020	COG4942	peptidase
ISA71_RS11040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISA71_RS11050	COG4974	Belongs to the 'phage' integrase family
ISA71_RS11055	COG0716	FMN binding
ISA71_RS11065	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISA71_RS11075	COG1272	protein, Hemolysin III
ISA71_RS11085	COG1737	Transcriptional regulator
ISA71_RS11090	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS11110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA71_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS11140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA71_RS11145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA71_RS11150	COG0006	proline dipeptidase activity
ISA71_RS11170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISA71_RS11175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA71_RS11190	COG2968	Membrane
ISA71_RS11200	COG0668	transmembrane transport
ISA71_RS11205	COG0191	fructose-bisphosphate aldolase activity
ISA71_RS11220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA71_RS11225	COG0501	Belongs to the peptidase M48B family
ISA71_RS11260	COG2814	Major facilitator Superfamily
ISA71_RS11270	COG2356	endonuclease I
ISA71_RS11275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISA71_RS11280	COG0189	ligase activity
ISA71_RS11300	COG2805	Type II/IV secretion system protein
ISA71_RS11305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISA71_RS11310	COG0762	integral membrane protein
ISA71_RS11325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA71_RS11340	COG4214	carbohydrate transport
ISA71_RS11350	COG3171	Protein conserved in bacteria
ISA71_RS11360	COG1194	a g-specific adenine glycosylase
ISA71_RS11375	COG2211	Major facilitator Superfamily
ISA71_RS11380	COG1982	Orn Lys Arg decarboxylase major
ISA71_RS11385	COG1811	Na channel or pump
ISA71_RS11420	COG0626	cystathionine gamma-synthase activity
ISA71_RS11425	COG0583	DNA-binding transcription factor activity
ISA71_RS11445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA71_RS11450	COG0754	glutathionylspermidine amidase activity
ISA71_RS11465	COG0625	glutathione transferase activity
ISA71_RS11490	COG2211	Major facilitator Superfamily
ISA71_RS11495	COG0848	biopolymer transport protein
ISA71_RS11505	COG0626	cystathionine gamma-synthase activity
ISA71_RS11510	COG0586	Pfam SNARE associated Golgi protein
ISA71_RS11515	COG2207	Transcriptional regulator
ISA71_RS11520	COG1979	alcohol dehydrogenase
ISA71_RS11525	COG0656	L-ascorbic acid biosynthetic process
ISA71_RS11535	COG1032	radical SAM domain protein
ISA71_RS11540	COG2132	Multicopper oxidase
ISA71_RS11545	COG0204	Acyl-transferase
ISA71_RS11550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISA71_RS11555	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ISA71_RS11560	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA71_RS11570	COG0642	Histidine kinase
ISA71_RS11575	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA71_RS11580	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISA71_RS11590	COG3150	esterase
ISA71_RS11595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA71_RS11600	COG3151	Protein conserved in bacteria
ISA71_RS11605	COG0494	nUDIX hydrolase
ISA71_RS11620	COG0754	glutathionylspermidine amidase activity
ISA71_RS11625	COG3384	dioxygenase
ISA71_RS11640	COG2960	long-chain fatty acid transporting porin activity
ISA71_RS11665	COG3025	triphosphatase activity
ISA71_RS11670	COG4991	sh3 domain protein
ISA71_RS11685	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA71_RS11750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISA71_RS11755	COG0358	DNA primase activity
ISA71_RS11760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA71_RS11785	COG2197	response regulator
ISA71_RS11790	COG0784	Response regulator, receiver
ISA71_RS11790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS11790	COG2205	protein histidine kinase activity
ISA71_RS11790	COG2198	Histidine kinase
ISA71_RS11800	COG3247	response to pH
ISA71_RS11870	COG2376	Dihydroxyacetone kinase
ISA71_RS11875	COG1461	Dihydroxyacetone kinase
ISA71_RS11890	COG2375	cellular response to nickel ion
ISA71_RS11895	COG1695	Transcriptional regulator
ISA71_RS11945	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISA71_RS11945	COG1902	pentaerythritol trinitrate reductase activity
ISA71_RS11965	COG1451	nucleotide metabolic process
ISA71_RS11970	COG0673	inositol 2-dehydrogenase activity
ISA71_RS11975	COG0861	Integral membrane protein TerC family
ISA71_RS11990	COG2721	sulfolactate sulfo-lyase activity
ISA71_RS12000	COG2271	Major facilitator Superfamily
ISA71_RS12005	COG2186	Transcriptional regulator
ISA71_RS12010	COG0586	Pfam SNARE associated Golgi protein
ISA71_RS12020	COG1422	Protein of unknown function (DUF1090)
ISA71_RS12025	COG4575	ribosome binding
ISA71_RS12030	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISA71_RS12040	COG2259	Doxx family
ISA71_RS12045	COG0435	Glutathione S-transferase
ISA71_RS12050	COG3152	Membrane
ISA71_RS12055	COG0583	DNA-binding transcription factor activity
ISA71_RS12060	COG1741	Belongs to the pirin family
ISA71_RS12085	COG1929	Belongs to the glycerate kinase type-1 family
ISA71_RS12090	COG2084	Dehydrogenase
ISA71_RS12100	COG2271	Major facilitator Superfamily
ISA71_RS12105	COG2721	sulfolactate sulfo-lyase activity
ISA71_RS12110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISA71_RS12130	COG2823	Periplasmic or secreted lipoprotein
ISA71_RS12135	COG0701	Predicted permease
ISA71_RS12140	COG0702	epimerase
ISA71_RS12145	COG0693	protein deglycase activity
ISA71_RS12160	COG3153	acetyltransferase
ISA71_RS12165	COG3154	lipid carrier protein
ISA71_RS12170	COG0826	peptidase U32
ISA71_RS12175	COG0826	peptidase U32
ISA71_RS12180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA71_RS12185	COG0814	amino acid
ISA71_RS12230	COG0195	Participates in both transcription termination and antitermination
ISA71_RS12270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISA71_RS12280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISA71_RS12285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISA71_RS12295	COG1534	Rna-binding protein
ISA71_RS12305	COG2027	D-alanyl-D-alanine carboxypeptidase
ISA71_RS12315	COG0697	spore germination
ISA71_RS12330	COG0142	geranyltranstransferase activity
ISA71_RS12335	COG3423	Transcriptional regulator
ISA71_RS12345	COG5007	Belongs to the BolA IbaG family
ISA71_RS12350	COG3113	response to antibiotic
ISA71_RS12355	COG2854	intermembrane phospholipid transfer
ISA71_RS12360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA71_RS12365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISA71_RS12370	COG1127	ABC transporter
ISA71_RS12375	COG0530	calcium, potassium:sodium antiporter activity
ISA71_RS12385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISA71_RS12390	COG3117	lipopolysaccharide transmembrane transporter activity
ISA71_RS12395	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISA71_RS12400	COG1137	ATPase activity
ISA71_RS12405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISA71_RS12410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA71_RS12415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS12425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS12430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA71_RS12435	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISA71_RS12440	COG0784	Response regulator, receiver
ISA71_RS12440	COG5002	protein histidine kinase activity
ISA71_RS12440	COG2198	Histidine kinase
ISA71_RS12445	COG1312	Catalyzes the dehydration of D-mannonate
ISA71_RS12450	COG1063	alcohol dehydrogenase
ISA71_RS12455	COG2271	Major facilitator Superfamily
ISA71_RS12460	COG1242	4 iron, 4 sulfur cluster binding
ISA71_RS12465	COG0067	glutamate synthase
ISA71_RS12465	COG0069	glutamate synthase activity
ISA71_RS12465	COG0070	glutamate synthase
ISA71_RS12470	COG0493	'glutamate synthase
ISA71_RS12480	COG2969	positive regulation of protein catabolic process
ISA71_RS12485	COG0625	glutathione transferase activity
ISA71_RS12505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA71_RS12510	COG3105	Protein conserved in bacteria
ISA71_RS12515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA71_RS12520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA71_RS12545	COG2732	(Barnase) inhibitor
ISA71_RS12550	COG1289	transmembrane transporter activity
ISA71_RS12565	COG0583	DNA-binding transcription factor activity
ISA71_RS12570	COG0312	modulator of DNA gyrase
ISA71_RS12575	COG3164	Protein of unknown function
ISA71_RS12580	COG1530	ribonuclease E activity
ISA71_RS12590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISA71_RS12595	COG1792	Involved in formation and maintenance of cell shape
ISA71_RS12600	COG1077	Cell shape determining protein MreB Mrl
ISA71_RS12605	COG2199	diguanylate cyclase activity
ISA71_RS12605	COG2200	EAL domain
ISA71_RS12630	COG0511	ligase activity, forming carbon-carbon bonds
ISA71_RS12635	COG0439	Biotin carboxylase
ISA71_RS12640	COG3924	membrane
ISA71_RS12645	COG4145	pantothenate transmembrane transporter activity
ISA71_RS12665	COG1309	transcriptional regulator
ISA71_RS12670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS12675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA71_RS12710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA71_RS12730	COG0551	DNA topoisomerase type I activity
ISA71_RS12740	COG0758	DNA mediated transformation
ISA71_RS12770	COG3036	rescue of stalled ribosome
ISA71_RS12775	COG0789	Transcriptional regulator
ISA71_RS12790	COG0202	RNA polymerase activity
ISA71_RS12815	COG0201	protein transport
ISA71_RS12880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISA71_RS12895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISA71_RS12920	COG0051	transcription antitermination factor activity, RNA binding
ISA71_RS12975	COG2964	Protein conserved in bacteria
ISA71_RS12980	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA71_RS12990	COG1047	Peptidyl-prolyl cis-trans
ISA71_RS12995	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISA71_RS13010	COG0488	(ABC) transporter
ISA71_RS13015	COG0429	hydrolase of the alpha beta-hydrolase fold
ISA71_RS13025	COG3954	Phosphoribulokinase
ISA71_RS13030	COG1765	OsmC-like protein
ISA71_RS13040	COG1289	transmembrane transporter activity
ISA71_RS13045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA71_RS13070	COG0738	Major facilitator superfamily
ISA71_RS13075	COG0402	S-adenosylhomocysteine deaminase activity
ISA71_RS13080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA71_RS13105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA71_RS13110	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ISA71_RS13115	COG3266	domain, Protein
ISA71_RS13130	COG4796	Type ii and iii secretion system protein
ISA71_RS13155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISA71_RS13160	COG0494	nUDIX hydrolase
ISA71_RS13170	COG1011	Hydrolase
ISA71_RS13175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISA71_RS13200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA71_RS13205	COG2183	response to ionizing radiation
ISA71_RS13210	COG1918	ferrous iron import across plasma membrane
ISA71_RS13235	COG1040	competence protein
ISA71_RS13245	COG2610	gluconate transmembrane transporter activity
ISA71_RS13250	COG1640	4-alpha-glucanotransferase
ISA71_RS13255	COG0058	SHG alpha-glucan phosphorylase activity
ISA71_RS13265	COG1349	DNA-binding transcription factor activity
ISA71_RS13280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA71_RS13295	COG0058	SHG alpha-glucan phosphorylase activity
ISA71_RS13320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA71_RS13330	COG2610	gluconate transmembrane transporter activity
ISA71_RS13335	COG3265	gluconokinase activity
ISA71_RS13340	COG1609	Transcriptional regulator
ISA71_RS13345	COG1741	Belongs to the pirin family
ISA71_RS13350	COG0673	inositol 2-dehydrogenase activity
ISA71_RS13360	COG1247	-acetyltransferase
ISA71_RS13365	COG0405	Gamma-glutamyltransferase
ISA71_RS13375	COG0584	glycerophosphoryl diester phosphodiesterase
ISA71_RS13425	COG0559	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS13430	COG0683	leucine binding
ISA71_RS13440	COG0683	leucine binding
ISA71_RS13450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA71_RS13465	COG2177	Part of the ABC transporter FtsEX involved in
ISA71_RS13470	COG2884	Cell division ATP-binding protein ftsE
ISA71_RS13475	COG0552	protein localization to endoplasmic reticulum
ISA71_RS13480	COG0742	ribosomal rna small subunit methyltransferase
ISA71_RS13485	COG3776	membrane
ISA71_RS13495	COG3714	YhhN family
ISA71_RS13510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISA71_RS13520	COG0477	Major facilitator Superfamily
ISA71_RS13525	COG0628	permease
ISA71_RS13565	COG3479	Phenolic acid decarboxylase
ISA71_RS13575	COG0747	negative chemotaxis
ISA71_RS13580	COG0601	transmembrane transport
ISA71_RS13585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS13595	COG1124	(ABC) transporter
ISA71_RS13610	COG2239	Acts as a magnesium transporter
ISA71_RS13615	COG2081	HI0933 family
ISA71_RS13620	COG0306	phosphate transporter
ISA71_RS13630	COG0589	response to stress
ISA71_RS13650	COG0671	phosphoesterase, PA-phosphatase related
ISA71_RS13655	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISA71_RS13660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA71_RS13670	COG1454	alcohol dehydrogenase
ISA71_RS13680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA71_RS13685	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS13690	COG0583	DNA-binding transcription factor activity
ISA71_RS13695	COG1295	ribonuclease BN
ISA71_RS13700	COG0477	Major facilitator Superfamily
ISA71_RS13705	COG2982	Protein involved in outer membrane biogenesis
ISA71_RS13715	COG0612	Peptidase, M16
ISA71_RS13725	COG2199	diguanylate cyclase activity
ISA71_RS13725	COG2200	EAL domain
ISA71_RS13730	COG0457	Tetratricopeptide repeat
ISA71_RS13730	COG3118	belongs to the thioredoxin family
ISA71_RS13735	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISA71_RS13740	COG1215	transferase activity, transferring glycosyl groups
ISA71_RS13770	COG2194	sulfuric ester hydrolase activity
ISA71_RS13785	COG0457	Tetratricopeptide repeat
ISA71_RS13790	COG1215	transferase activity, transferring glycosyl groups
ISA71_RS13800	COG2894	cell division
ISA71_RS13815	COG4608	Belongs to the ABC transporter superfamily
ISA71_RS13820	COG0444	Belongs to the ABC transporter superfamily
ISA71_RS13825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS13830	COG0601	transmembrane transport
ISA71_RS13835	COG0747	negative chemotaxis
ISA71_RS13855	COG2223	nitrite transmembrane transporter activity
ISA71_RS13860	COG5571	outer membrane autotransporter
ISA71_RS13865	COG2818	Glycosylase
ISA71_RS13870	COG0456	acetyltransferase
ISA71_RS13875	COG0243	molybdopterin cofactor binding
ISA71_RS13880	COG2885	chlorophyll binding
ISA71_RS13885	COG1609	Transcriptional regulator
ISA71_RS13895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA71_RS13915	COG2814	Major facilitator Superfamily
ISA71_RS13920	COG2944	sequence-specific DNA binding
ISA71_RS13925	COG1278	Cold shock
ISA71_RS13930	COG0488	(ABC) transporter
ISA71_RS13955	COG3274	enterobacterial common antigen metabolic process
ISA71_RS13960	COG4682	membrane
ISA71_RS13965	COG4682	membrane
ISA71_RS13980	COG4213	ABC transporter substrate-binding protein
ISA71_RS13990	COG4214	carbohydrate transport
ISA71_RS13995	COG1609	Transcriptional regulator
ISA71_RS13995	COG2207	Transcriptional regulator
ISA71_RS14000	COG2992	FlgJ-related protein
ISA71_RS14005	COG0366	Alpha amylase catalytic
ISA71_RS14010	COG3977	Valine--pyruvate aminotransferase
ISA71_RS14015	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA71_RS14020	COG1414	Transcriptional regulator
ISA71_RS14030	COG2731	YhcH YjgK YiaL family protein
ISA71_RS14040	COG2271	Major facilitator Superfamily
ISA71_RS14045	COG1070	Carbohydrate kinase
ISA71_RS14050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ISA71_RS14055	COG3623	hexulose-6-phosphate isomerase
ISA71_RS14060	COG0235	Class ii aldolase
ISA71_RS14065	COG3276	selenocysteine insertion sequence binding
ISA71_RS14075	COG0625	glutathione transferase activity
ISA71_RS14095	COG3722	fumarate hydratase activity
ISA71_RS14115	COG2186	Transcriptional regulator
ISA71_RS14125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISA71_RS14145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA71_RS14150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA71_RS14160	COG4942	peptidase
ISA71_RS14165	COG2861	carbohydrate metabolic process
ISA71_RS14170	COG0463	Glycosyl transferase, family 2
ISA71_RS14180	COG0156	8-amino-7-oxononanoate synthase activity
ISA71_RS14195	COG0859	PFAM glycosyl transferase family 9
ISA71_RS14220	COG0859	PFAM glycosyl transferase family 9
ISA71_RS14230	COG0438	transferase activity, transferring glycosyl groups
ISA71_RS14235	COG1216	Glycosyl transferase, family 2
ISA71_RS14240	COG1519	Transferase
ISA71_RS14275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISA71_RS14305	COG0842	Transport permease protein
ISA71_RS14310	COG1131	(ABC) transporter
ISA71_RS14330	COG1561	YicC-like family, N-terminal region
ISA71_RS14335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ISA71_RS14340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA71_RS14340	COG2169	Transcriptional regulator
ISA71_RS14350	COG2860	membrane
ISA71_RS14370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA71_RS14375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA71_RS14380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISA71_RS14385	COG1494	fructose-1,6-bisphosphatase
ISA71_RS14395	COG3152	Membrane
ISA71_RS14420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISA71_RS14440	COG0786	glutamate:sodium symporter activity
ISA71_RS14445	COG2233	PERMEase
ISA71_RS14450	COG2982	Protein involved in outer membrane biogenesis
ISA71_RS14455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA71_RS14455	COG1263	PTS System
ISA71_RS14460	COG1486	melibiose metabolic process
ISA71_RS14470	COG1501	Belongs to the glycosyl hydrolase 31 family
ISA71_RS14475	COG2211	Major facilitator Superfamily
ISA71_RS14505	COG1064	alcohol dehydrogenase
ISA71_RS14515	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISA71_RS14530	COG1464	Belongs to the NlpA lipoprotein family
ISA71_RS14555	COG0583	DNA-binding transcription factor activity
ISA71_RS14590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA71_RS14600	COG2814	Major facilitator Superfamily
ISA71_RS14610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA71_RS14610	COG1263	PTS System
ISA71_RS14615	COG0697	spore germination
ISA71_RS14630	COG2828	Protein conserved in bacteria
ISA71_RS14635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISA71_RS14640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISA71_RS14645	COG0583	DNA-binding transcription factor activity
ISA71_RS14650	COG3384	dioxygenase
ISA71_RS14660	COG1609	Transcriptional regulator
ISA71_RS14670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS14670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS14675	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA71_RS14680	COG4580	involved in the transport of maltose and maltodextrins
ISA71_RS14705	COG2188	Transcriptional regulator
ISA71_RS14745	COG2271	Major facilitator Superfamily
ISA71_RS14755	COG2197	response regulator
ISA71_RS14760	COG0440	acetolactate synthase activity
ISA71_RS14765	COG0028	Belongs to the TPP enzyme family
ISA71_RS14795	COG2814	Major facilitator Superfamily
ISA71_RS14800	COG0583	DNA-binding transcription factor activity
ISA71_RS14810	COG2610	gluconate transmembrane transporter activity
ISA71_RS14830	COG2149	membrane
ISA71_RS14845	COG2188	Transcriptional regulator
ISA71_RS14855	COG3645	SOS response
ISA71_RS14870	COG5645	(Lipo)protein
ISA71_RS14875	COG0823	Involved in the tonB-independent uptake of proteins
ISA71_RS14880	COG2271	Major facilitator Superfamily
ISA71_RS14890	COG0800	Aldolase
ISA71_RS14895	COG3734	2-keto-3-deoxy-galactonokinase
ISA71_RS14900	COG2186	Transcriptional regulator
ISA71_RS14915	COG0561	phosphatase activity
ISA71_RS14920	COG0187	DNA topoisomerase II activity
ISA71_RS14950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISA71_RS14980	COG2091	lysine biosynthetic process via aminoadipic acid
ISA71_RS14985	COG0431	NADPH-dependent FMN reductase
ISA71_RS14990	COG2252	PERMEase
ISA71_RS14995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA71_RS15000	COG0363	glucosamine-6-phosphate deaminase activity
ISA71_RS15005	COG2382	esterase
ISA71_RS15015	COG0704	Plays a role in the regulation of phosphate uptake
ISA71_RS15020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISA71_RS15025	COG0581	inorganic phosphate transmembrane transporter activity
ISA71_RS15030	COG0573	inorganic phosphate transmembrane transporter activity
ISA71_RS15035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISA71_RS15040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA71_RS15090	COG3312	ion transport
ISA71_RS15105	COG0716	FMN binding
ISA71_RS15110	COG1522	sequence-specific DNA binding
ISA71_RS15140	COG1129	ABC transporter
ISA71_RS15145	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS15155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA71_RS15160	COG1609	Transcriptional regulator
ISA71_RS15165	COG0477	Major facilitator Superfamily
ISA71_RS15170	COG2186	Transcriptional regulator
ISA71_RS15195	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISA71_RS15205	COG3084	Protein conserved in bacteria
ISA71_RS15210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISA71_RS15220	COG0204	Acyl-transferase
ISA71_RS15240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA71_RS15255	COG3852	Histidine kinase
ISA71_RS15270	COG1011	Hydrolase
ISA71_RS15285	COG0456	acetyltransferase
ISA71_RS15295	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISA71_RS15310	COG2864	formate dehydrogenase
ISA71_RS15315	COG0437	4 iron, 4 sulfur cluster binding
ISA71_RS15335	COG0205	6-phosphofructokinase activity
ISA71_RS15395	COG2211	Major facilitator Superfamily
ISA71_RS15405	COG1454	alcohol dehydrogenase
ISA71_RS15410	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS15415	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS15420	COG1129	ABC transporter
ISA71_RS15460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISA71_RS15465	COG2258	MOSC domain
ISA71_RS15470	COG2205	protein histidine kinase activity
ISA71_RS15475	COG0745	RESPONSE REGULATOR receiver
ISA71_RS15480	COG3678	ATP-independent chaperone mediated protein folding
ISA71_RS15500	COG1575	Belongs to the MenA family. Type 1 subfamily
ISA71_RS15515	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA71_RS15520	COG1609	Transcriptional regulator
ISA71_RS15525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISA71_RS15540	COG0626	cystathionine gamma-synthase activity
ISA71_RS15545	COG0527	aspartate kinase activity
ISA71_RS15545	COG0460	homoserine dehydrogenase
ISA71_RS15555	COG0737	Belongs to the 5'-nucleotidase family
ISA71_RS15565	COG0583	DNA-binding transcription factor activity
ISA71_RS15575	COG0697	spore germination
ISA71_RS15580	COG0371	Dehydrogenase
ISA71_RS15590	COG2207	Transcriptional regulator
ISA71_RS15595	COG3443	Belongs to the bacterial solute-binding protein 9 family
ISA71_RS15610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISA71_RS15625	COG0583	DNA-binding transcription factor activity
ISA71_RS15700	COG3085	chromosome segregation
ISA71_RS15720	COG3978	acetolactate synthase activity
ISA71_RS15735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA71_RS15740	COG0583	DNA-binding transcription factor activity
ISA71_RS15750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA71_RS15755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA71_RS15765	COG1811	Na channel or pump
ISA71_RS15790	COG3118	belongs to the thioredoxin family
ISA71_RS15795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISA71_RS15800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISA71_RS15810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISA71_RS15815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISA71_RS15820	COG1088	dTDP-glucose 4,6-dehydratase activity
ISA71_RS15825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISA71_RS15830	COG0456	acetyltransferase
ISA71_RS15835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISA71_RS15840	COG2244	polysaccharide biosynthetic process
ISA71_RS15885	COG3071	HemY protein
ISA71_RS15890	COG2959	enzyme of heme biosynthesis
ISA71_RS15905	COG3072	Adenylate cyclase
ISA71_RS15935	COG1011	Hydrolase
ISA71_RS15940	COG0210	DNA helicase
ISA71_RS15970	COG1280	lysine exporter protein (LysE YggA)
ISA71_RS15980	COG1280	lysine exporter protein (LysE YggA)
ISA71_RS15985	COG2267	carboxylic ester hydrolase activity
ISA71_RS15990	COG0561	phosphatase activity
ISA71_RS15995	COG0697	spore germination
ISA71_RS16000	COG0583	DNA-binding transcription factor activity
ISA71_RS16030	COG3165	ubiquinone biosynthetic process from chorismate
ISA71_RS16050	COG0805	protein transport
ISA71_RS16090	COG1739	Uncharacterized protein family UPF0029
ISA71_RS16100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISA71_RS16130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISA71_RS16175	COG0250	Participates in transcription elongation, termination and antitermination
ISA71_RS16210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA71_RS16215	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA71_RS16225	COG3706	GGDEF domain
ISA71_RS16240	COG2104	thiamine diphosphate biosynthetic process
ISA71_RS16245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA71_RS16260	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ISA71_RS16295	COG3678	ATP-independent chaperone mediated protein folding
ISA71_RS16300	COG4191	Histidine kinase
ISA71_RS16310	COG0151	Belongs to the GarS family
ISA71_RS16340	COG0456	acetyltransferase
ISA71_RS16350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISA71_RS16400	COG0527	aspartate kinase activity
ISA71_RS16410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISA71_RS16420	COG0251	oxidation-reduction process
ISA71_RS16490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISA71_RS16500	COG0534	Mate efflux family protein
ISA71_RS16510	COG3237	CsbD-like
ISA71_RS16515	COG0735	belongs to the Fur family
ISA71_RS16525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA71_RS16540	COG0305	Participates in initiation and elongation during chromosome replication
ISA71_RS16545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISA71_RS16560	COG0432	Pfam Uncharacterised protein family UPF0047
ISA71_RS16565	COG2315	Protein conserved in bacteria
ISA71_RS16580	COG0741	lytic transglycosylase activity
ISA71_RS16585	COG4771	TonB-dependent receptor
ISA71_RS16605	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA71_RS16615	COG0483	inositol monophosphate 1-phosphatase activity
ISA71_RS16620	COG1609	Transcriptional regulator
ISA71_RS16625	COG1234	tRNA 3'-trailer cleavage
ISA71_RS16655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA71_RS16665	COG0789	Transcriptional regulator
ISA71_RS16670	COG0625	glutathione transferase activity
ISA71_RS16675	COG2252	PERMEase
ISA71_RS16680	COG0025	NhaP-type Na H and K H
ISA71_RS16685	COG0583	DNA-binding transcription factor activity
ISA71_RS16690	COG1380	Effector of murein hydrolase LrgA
ISA71_RS16695	COG1346	cytolysis
ISA71_RS16700	COG3539	Fimbrial protein
ISA71_RS16730	COG3162	membrane
ISA71_RS16735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISA71_RS16745	COG1301	dicarboxylic acid transport
ISA71_RS16750	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ISA71_RS16775	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS16780	COG1129	ABC transporter
ISA71_RS16785	COG4191	Histidine kinase
ISA71_RS16785	COG0784	Response regulator, receiver
ISA71_RS16795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISA71_RS16805	COG3454	Phosphonate metabolism
ISA71_RS16810	COG4778	phosphonate C-P lyase system protein PhnL
ISA71_RS16815	COG4107	phosphonate C-P lyase system protein PhnK
ISA71_RS16820	COG3627	carbon phosphorus lyase activity
ISA71_RS16825	COG3626	phosphonate metabolism
ISA71_RS16830	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISA71_RS16835	COG3624	Phosphonate C-P lyase system protein PhnG
ISA71_RS16840	COG2188	Transcriptional regulator
ISA71_RS16845	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ISA71_RS16850	COG2824	Alkylphosphonate utilization operon protein PhnA
ISA71_RS16860	COG2169	Transcriptional regulator
ISA71_RS16865	COG1486	melibiose metabolic process
ISA71_RS16905	COG0861	Integral membrane protein TerC family
ISA71_RS16920	COG1215	transferase activity, transferring glycosyl groups
ISA71_RS16925	COG1649	PFAM Uncharacterised BCR, COG1649
ISA71_RS16925	COG0726	polysaccharide deacetylase
ISA71_RS16930	COG0457	Tetratricopeptide repeat
ISA71_RS16960	COG1309	transcriptional regulator
ISA71_RS16975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA71_RS16980	COG1027	Aspartate ammonia-lyase
ISA71_RS16985	COG3030	protein affecting phage T7 exclusion by the F plasmid
ISA71_RS16990	COG0531	amino acid
ISA71_RS17055	COG1509	lysine 2,3-aminomutase activity
ISA71_RS17070	COG5510	response to toxic substance
ISA71_RS17075	COG2076	Multidrug Resistance protein
ISA71_RS17095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA71_RS17100	COG1053	succinate dehydrogenase
ISA71_RS17115	COG3264	Mechanosensitive ion channel
ISA71_RS17115	COG1511	domain protein
ISA71_RS17135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS17155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISA71_RS17160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISA71_RS17160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISA71_RS17165	COG0802	atpase or kinase
ISA71_RS17170	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA71_RS17190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISA71_RS17195	COG0330	HflC and HflK could
ISA71_RS17200	COG0330	HflC and HflK could
ISA71_RS17210	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISA71_RS17225	COG0557	exoribonuclease II activity
ISA71_RS17230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA71_RS17235	COG1960	acyl-CoA dehydrogenase activity
ISA71_RS17245	COG3650	response to hydrogen peroxide
ISA71_RS17250	COG1073	alpha beta
ISA71_RS17310	COG2965	DNA replication, synthesis of RNA primer
ISA71_RS17315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISA71_RS17325	COG3061	Opacity-associated protein A
ISA71_RS17330	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA71_RS17335	COG1113	amino acid transport
ISA71_RS17345	COG0697	spore germination
ISA71_RS17355	COG0702	epimerase
ISA71_RS17360	COG1733	regulation of RNA biosynthetic process
ISA71_RS17375	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISA71_RS17400	COG1253	flavin adenine dinucleotide binding
ISA71_RS17410	COG0729	surface antigen
ISA71_RS17415	COG2911	Protein conserved in bacteria
ISA71_RS17420	COG2105	PFAM AIG2 family protein
ISA71_RS17435	COG1879	ABC-type sugar transport system periplasmic component
ISA71_RS17440	COG1129	ABC transporter
ISA71_RS17445	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS17450	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS17460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISA71_RS17485	COG0312	modulator of DNA gyrase
ISA71_RS17525	COG3964	amidohydrolase
ISA71_RS17540	COG2706	6-phosphogluconolactonase activity
ISA71_RS17545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS17545	COG3711	transcriptional antiterminator
ISA71_RS17550	COG3077	Addiction module antitoxin, RelB DinJ family
ISA71_RS17555	COG2026	Addiction module toxin, RelE StbE family
ISA71_RS17560	COG0602	queuosine metabolic process
ISA71_RS17585	COG1486	melibiose metabolic process
ISA71_RS17590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS17595	COG0366	Alpha amylase catalytic
ISA71_RS17600	COG1263	PTS System
ISA71_RS17600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA71_RS17635	COG2731	YhcH YjgK YiaL family protein
ISA71_RS17660	COG0525	valine-tRNA ligase activity
ISA71_RS17665	COG2927	DNA polymerase III (CHI subunit)
ISA71_RS17675	COG0795	lipopolysaccharide-transporting ATPase activity
ISA71_RS17680	COG0795	lipopolysaccharide-transporting ATPase activity
ISA71_RS17685	COG0433	COG0433 Predicted ATPase
ISA71_RS17700	COG3718	enzyme involved in inositol metabolism
ISA71_RS17705	COG0837	glucose binding
ISA71_RS17705	COG1737	Transcriptional regulator
ISA71_RS17710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA71_RS17715	COG3962	Belongs to the TPP enzyme family
ISA71_RS17725	COG1082	Xylose isomerase domain protein TIM barrel
ISA71_RS17740	COG3842	ATPase activity
ISA71_RS17745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA71_RS17750	COG0395	ABC-type sugar transport system, permease component
ISA71_RS17755	COG1175	transmembrane transport
ISA71_RS17760	COG1064	alcohol dehydrogenase
ISA71_RS17765	COG0659	secondary active sulfate transmembrane transporter activity
ISA71_RS17770	COG0288	reversible hydration of carbon dioxide
ISA71_RS17780	COG0582	viral genome integration into host DNA
ISA71_RS17885	COG0084	hydrolase, TatD family'
ISA71_RS17915	COG1216	Glycosyl transferase, family 2
ISA71_RS17935	COG3507	Belongs to the glycosyl hydrolase 43 family
ISA71_RS17940	COG2211	Major facilitator Superfamily
ISA71_RS17945	COG2115	Belongs to the xylose isomerase family
ISA71_RS17950	COG4580	involved in the transport of maltose and maltodextrins
ISA71_RS17955	COG3272	Protein of unknown function (DUF1722)
ISA71_RS17975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA71_RS17990	COG0300	oxidoreductase activity
ISA71_RS17995	COG3631	Ketosteroid isomerase-related protein
ISA71_RS18000	COG0789	Transcriptional regulator
ISA71_RS18005	COG3040	lipid binding
ISA71_RS18015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA71_RS18020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS18025	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS18030	COG1538	Outer membrane efflux protein
ISA71_RS18035	COG0745	RESPONSE REGULATOR receiver
ISA71_RS18040	COG5002	protein histidine kinase activity
ISA71_RS18055	COG2850	peptidyl-arginine hydroxylation
ISA71_RS18085	COG0842	Transport permease protein
ISA71_RS18090	COG0842	Transport permease protein
ISA71_RS18090	COG1129	ABC transporter
ISA71_RS18095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS18100	COG3706	GGDEF domain
ISA71_RS18110	COG1879	ABC-type sugar transport system periplasmic component
ISA71_RS18115	COG1129	ABC transporter
ISA71_RS18120	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS18130	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA71_RS18135	COG0583	DNA-binding transcription factor activity
ISA71_RS18145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA71_RS18150	COG5457	Domain of unknown function (DUF1127)
ISA71_RS18160	COG1566	PFAM secretion protein HlyD family protein
ISA71_RS18175	COG1924	4 iron, 4 sulfur cluster binding
ISA71_RS18180	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ISA71_RS18195	COG2733	membrane
ISA71_RS18205	COG2207	Transcriptional regulator
ISA71_RS18205	COG1917	Cupin 2, conserved barrel domain protein
ISA71_RS18210	COG5464	transposase or invertase
ISA71_RS18215	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS18225	COG0523	cobalamin synthesis protein
ISA71_RS18230	COG2879	small protein
ISA71_RS18235	COG1966	Carbon starvation protein
ISA71_RS18250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA71_RS18255	COG2368	4-hydroxyphenylacetate
ISA71_RS18275	COG3971	2-oxopent-4-enoate hydratase activity
ISA71_RS18285	COG3384	dioxygenase
ISA71_RS18290	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS18300	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA71_RS18310	COG1846	Transcriptional regulator
ISA71_RS18340	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ISA71_RS18355	COG3734	2-keto-3-deoxy-galactonokinase
ISA71_RS18360	COG0800	Aldolase
ISA71_RS18365	COG1737	Transcriptional regulator
ISA71_RS18375	COG1214	PFAM Peptidase M22, glycoprotease
ISA71_RS18375	COG0456	acetyltransferase
ISA71_RS18380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA71_RS18380	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISA71_RS18395	COG3715	PTS system
ISA71_RS18400	COG3716	PTS system mannose fructose sorbose family IID component
ISA71_RS18405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA71_RS18410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA71_RS18415	COG5464	transposase or invertase
ISA71_RS18430	COG1484	DNA-dependent DNA replication
ISA71_RS18445	COG2966	Psort location CytoplasmicMembrane, score
ISA71_RS18460	COG2197	response regulator
ISA71_RS18465	COG2197	response regulator
ISA71_RS18470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA71_RS18475	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS18475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS18480	COG4114	ferric iron reductase
ISA71_RS18485	COG3706	GGDEF domain
ISA71_RS18520	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISA71_RS18525	COG0456	acetyltransferase
ISA71_RS18530	COG1011	Hydrolase
ISA71_RS18540	COG2823	Periplasmic or secreted lipoprotein
ISA71_RS18545	COG5487	UPF0391 membrane protein
ISA71_RS18550	COG4667	esterase of the alpha-beta hydrolase superfamily
ISA71_RS18555	COG0084	hydrolase, TatD family'
ISA71_RS18560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA71_RS18590	COG3726	membrane protein affecting hemolysin expression
ISA71_RS18595	COG0560	Phosphoserine phosphatase
ISA71_RS18600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISA71_RS18610	COG0488	(ABC) transporter
ISA71_RS18615	COG0741	lytic transglycosylase activity
ISA71_RS18635	COG2207	Transcriptional regulator
ISA71_RS18635	COG3708	Transcriptional regulator
ISA71_RS18640	COG3045	CreA protein
ISA71_RS18645	COG0745	RESPONSE REGULATOR receiver
ISA71_RS18650	COG2205	protein histidine kinase activity
ISA71_RS18655	COG4452	Inner membrane protein CreD
ISA71_RS18660	COG0745	RESPONSE REGULATOR receiver
ISA71_RS18670	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ISA71_RS18680	COG0460	homoserine dehydrogenase
ISA71_RS18680	COG0527	aspartate kinase activity
ISA71_RS18690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISA71_RS18705	COG1115	amino acid carrier protein
ISA71_RS18710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA71_RS18715	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA71_RS18720	COG0477	Major facilitator Superfamily
ISA71_RS18725	COG1584	GPR1 FUN34 yaaH family protein
ISA71_RS18730	COG4735	regulation of single-species biofilm formation
ISA71_RS18755	COG0583	DNA-binding transcription factor activity
ISA71_RS18765	COG0196	riboflavin kinase activity
ISA71_RS18780	COG1047	Peptidyl-prolyl cis-trans
ISA71_RS18795	COG3152	Membrane
ISA71_RS18805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISA71_RS18815	COG0505	Belongs to the CarA family
ISA71_RS18860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA71_RS18870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISA71_RS18875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISA71_RS18890	COG3493	citrate carrier protein
ISA71_RS18900	COG0564	pseudouridine synthase activity
ISA71_RS18910	COG0417	DNA replication proofreading
ISA71_RS18915	COG0235	Class ii aldolase
ISA71_RS18935	COG0586	Pfam SNARE associated Golgi protein
ISA71_RS18945	COG1178	ABC-type Fe3 transport system permease component
ISA71_RS18965	COG2814	Major facilitator Superfamily
ISA71_RS18970	COG2271	Major facilitator Superfamily
ISA71_RS18975	COG0583	DNA-binding transcription factor activity
ISA71_RS18985	COG0738	Major facilitator superfamily
ISA71_RS19030	COG0028	Belongs to the TPP enzyme family
ISA71_RS19040	COG1609	Transcriptional regulator
ISA71_RS19060	COG0768	penicillin binding
ISA71_RS19065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISA71_RS19070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISA71_RS19085	COG0772	Belongs to the SEDS family
ISA71_RS19110	COG0849	cell division
ISA71_RS19115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISA71_RS19135	COG0494	nUDIX hydrolase
ISA71_RS19160	COG1459	type II secretion system
ISA71_RS19165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISA71_RS19170	COG4969	Belongs to the N-Me-Phe pilin family
ISA71_RS19180	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA71_RS19185	COG3725	Membrane protein required for beta-lactamase induction
ISA71_RS19190	COG3940	Belongs to the glycosyl hydrolase 43 family
ISA71_RS19195	COG2211	Major facilitator Superfamily
ISA71_RS19200	COG1113	amino acid transport
ISA71_RS19205	COG2186	Transcriptional regulator
ISA71_RS19210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISA71_RS19215	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA71_RS19220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA71_RS19235	COG3064	Membrane
ISA71_RS19280	COG2132	Multicopper oxidase
ISA71_RS19285	COG4993	Dehydrogenase
ISA71_RS19300	COG0288	reversible hydration of carbon dioxide
ISA71_RS19305	COG1131	(ABC) transporter
ISA71_RS19310	COG0842	Transport permease protein
ISA71_RS19315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS19320	COG0726	polysaccharide deacetylase
ISA71_RS19340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISA71_RS19345	COG0617	tRNA 3'-terminal CCA addition
ISA71_RS19365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISA71_RS19370	COG1643	Atp-dependent helicase
ISA71_RS19465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA71_RS19470	COG4774	siderophore transport
ISA71_RS19475	COG1120	ATPase activity
ISA71_RS19480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA71_RS19485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS19505	COG2860	membrane
ISA71_RS19525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA71_RS19530	COG3835	regulator
ISA71_RS19545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ISA71_RS19550	COG0024	Methionine aminopeptidase
ISA71_RS19575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISA71_RS19585	COG0575	Belongs to the CDS family
ISA71_RS19590	COG0750	zinc metalloprotease
ISA71_RS19600	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ISA71_RS19630	COG0587	DNA-directed DNA polymerase activity
ISA71_RS19640	COG1982	Orn Lys Arg decarboxylase major
ISA71_RS19645	COG0346	lactoylglutathione lyase activity
ISA71_RS19655	COG4568	rho-dependent transcription termination
ISA71_RS19670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ISA71_RS19675	COG3015	lipoprotein NlpE involved in copper resistance
ISA71_RS19680	COG0791	NLP P60 protein
ISA71_RS19690	COG1720	tRNA m6t6A37 methyltransferase activity
ISA71_RS19700	COG1464	Belongs to the NlpA lipoprotein family
ISA71_RS19705	COG2011	ABC-type metal ion transport system permease component
ISA71_RS19715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISA71_RS19750	COG0656	L-ascorbic acid biosynthetic process
ISA71_RS19755	COG0583	DNA-binding transcription factor activity
ISA71_RS19760	COG2814	Major facilitator Superfamily
ISA71_RS19770	COG2226	methyltransferase
ISA71_RS19775	COG0741	lytic transglycosylase activity
ISA71_RS19775	COG1388	LysM domain
ISA71_RS19785	COG2226	methyltransferase
ISA71_RS19795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA71_RS19805	COG0583	DNA-binding transcription factor activity
ISA71_RS19815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA71_RS19820	COG1960	acyl-CoA dehydrogenase activity
ISA71_RS19830	COG0121	glutamine amidotransferase
ISA71_RS19835	COG3034	peptidoglycan biosynthetic process
ISA71_RS19850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA71_RS19855	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA71_RS19870	COG2991	Protein conserved in bacteria
ISA71_RS19885	COG0454	-acetyltransferase
ISA71_RS19890	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISA71_RS19920	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS19930	COG0583	DNA-binding transcription factor activity
ISA71_RS19940	COG1802	Transcriptional regulator
ISA71_RS19945	COG1113	amino acid transport
ISA71_RS19950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA71_RS19955	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS19960	COG0579	oxidoreductase
ISA71_RS19975	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISA71_RS19980	COG0625	glutathione transferase activity
ISA71_RS19985	COG3775	system Galactitol-specific IIC component
ISA71_RS19990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA71_RS19995	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS20000	COG1070	Carbohydrate kinase
ISA71_RS20020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA71_RS20025	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA71_RS20030	COG0022	dehydrogenase e1 component
ISA71_RS20035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISA71_RS20040	COG2909	trisaccharide binding
ISA71_RS20055	COG4581	dead DEAH box helicase
ISA71_RS20130	COG0582	viral genome integration into host DNA
ISA71_RS20155	COG0791	NLP P60 protein
ISA71_RS20170	COG2801	Transposase and inactivated derivatives
ISA71_RS20180	COG3639	organic phosphonate transmembrane transporter activity
ISA71_RS20190	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISA71_RS20215	COG3188	usher protein
ISA71_RS20230	COG0765	amino acid transport
ISA71_RS20235	COG4597	amino acid ABC transporter
ISA71_RS20240	COG1126	abc transporter atp-binding protein
ISA71_RS20245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS20285	COG4302	ethanolamine ammonia-lyase activity
ISA71_RS20290	COG4303	Ethanolamine ammonia lyase large subunit
ISA71_RS20305	COG0833	amino acid
ISA71_RS20310	COG2040	homocysteine
ISA71_RS20315	COG4521	taurine ABC transporter
ISA71_RS20320	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ISA71_RS20325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA71_RS20330	COG2175	clavaminate synthase activity
ISA71_RS20340	COG1943	Transposase
ISA71_RS20345	COG0113	porphobilinogen synthase activity
ISA71_RS20350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISA71_RS20355	COG1335	isochorismatase
ISA71_RS20360	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ISA71_RS20400	COG1785	Belongs to the alkaline phosphatase family
ISA71_RS20410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISA71_RS20420	COG3416	Protein conserved in bacteria
ISA71_RS20425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA71_RS20435	COG4126	flavin adenine dinucleotide binding
ISA71_RS20450	COG1940	carbohydrate kinase activity
ISA71_RS20455	COG0419	ATPase involved in DNA repair
ISA71_RS20460	COG0420	3'-5' exonuclease activity
ISA71_RS20485	COG0366	Alpha amylase catalytic
ISA71_RS20490	COG0583	DNA-binding transcription factor activity
ISA71_RS20495	COG1335	isochorismatase
ISA71_RS20505	COG1228	amidohydrolase
ISA71_RS20515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA71_RS20530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS20540	COG0450	alkyl hydroperoxide reductase
ISA71_RS20565	COG1862	Preprotein translocase
ISA71_RS20570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA71_RS20575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA71_RS20595	COG4238	major outer membrane lipoprotein
ISA71_RS20605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA71_RS20605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA71_RS20620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISA71_RS20625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISA71_RS20630	COG0667	Aldo Keto reductase
ISA71_RS20640	COG0142	geranyltranstransferase activity
ISA71_RS20660	COG0693	protein deglycase activity
ISA71_RS20665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISA71_RS20675	COG2814	Major facilitator Superfamily
ISA71_RS20680	COG0673	inositol 2-dehydrogenase activity
ISA71_RS20695	COG1053	succinate dehydrogenase
ISA71_RS20705	COG1053	succinate dehydrogenase
ISA71_RS20710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA71_RS20715	COG1414	Transcriptional regulator
ISA71_RS20730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISA71_RS20735	COG1845	cytochrome c oxidase, subunit III
ISA71_RS20740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISA71_RS20745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISA71_RS20750	COG2223	nitrite transmembrane transporter activity
ISA71_RS20755	COG3056	Lipoprotein
ISA71_RS20760	COG0271	Belongs to the BolA IbaG family
ISA71_RS20780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISA71_RS20785	COG0776	regulation of translation
ISA71_RS20790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA71_RS20795	COG1555	photosystem II stabilization
ISA71_RS20800	COG0824	Thioesterase
ISA71_RS20810	COG4533	DNA binding
ISA71_RS20825	COG1522	sequence-specific DNA binding
ISA71_RS20830	COG1132	(ABC) transporter
ISA71_RS20835	COG1132	(ABC) transporter
ISA71_RS20840	COG0347	Belongs to the P(II) protein family
ISA71_RS20845	COG0004	ammonium transporteR
ISA71_RS20850	COG1946	Acyl-CoA thioesterase
ISA71_RS20855	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISA71_RS20860	COG3695	enzyme binding
ISA71_RS20890	COG2364	Membrane
ISA71_RS20905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA71_RS20915	COG2182	Extracellular solute-binding protein
ISA71_RS20920	COG1175	transmembrane transport
ISA71_RS20925	COG3833	ABC-type maltose transport systems, permease component
ISA71_RS20930	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISA71_RS20935	COG1874	Beta-galactosidase
ISA71_RS20985	COG0110	maltose O-acetyltransferase activity
ISA71_RS21000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA71_RS21005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS21010	COG1309	transcriptional regulator
ISA71_RS21015	COG3264	Mechanosensitive ion channel
ISA71_RS21015	COG1196	nuclear chromosome segregation
ISA71_RS21030	COG3923	Primosomal replication protein n
ISA71_RS21035	COG2832	Protein of unknown function (DUF454)
ISA71_RS21075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA71_RS21080	COG4651	solute:proton antiporter activity
ISA71_RS21080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISA71_RS21085	COG2223	nitrite transmembrane transporter activity
ISA71_RS21095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA71_RS21100	COG3735	TraB family
ISA71_RS21115	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISA71_RS21120	COG0330	HflC and HflK could
ISA71_RS21125	COG4619	ABC transporter
ISA71_RS21130	COG0390	transport system, permease component
ISA71_RS21135	COG3118	belongs to the thioredoxin family
ISA71_RS21140	COG0300	oxidoreductase activity
ISA71_RS21145	COG2755	lipolytic protein G-D-S-L family
ISA71_RS21150	COG4181	ATPase activity
ISA71_RS21155	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISA71_RS21175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISA71_RS21180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISA71_RS21195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISA71_RS21205	COG2501	S4 domain
ISA71_RS21255	COG3539	Fimbrial protein
ISA71_RS21260	COG3121	Chaperone
ISA71_RS21265	COG3188	usher protein
ISA71_RS21280	COG1560	Kdo2-lipid A biosynthetic process
ISA71_RS21290	COG3710	Transcriptional regulator
ISA71_RS21295	COG0531	amino acid
ISA71_RS21300	COG1982	Orn Lys Arg decarboxylase major
ISA71_RS21305	COG3104	oligopeptide transport
ISA71_RS21335	COG0673	inositol 2-dehydrogenase activity
ISA71_RS21350	COG1129	ABC transporter
ISA71_RS21355	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS21400	COG1566	PFAM secretion protein HlyD family protein
ISA71_RS21405	COG1120	ATPase activity
ISA71_RS21410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS21440	COG1473	amidohydrolase
ISA71_RS21445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS21450	COG0667	Aldo Keto reductase
ISA71_RS21500	COG0531	amino acid
ISA71_RS21515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA71_RS21520	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS21535	COG1113	amino acid transport
ISA71_RS21540	COG2211	Major facilitator Superfamily
ISA71_RS21550	COG0673	inositol 2-dehydrogenase activity
ISA71_RS21560	COG1609	Transcriptional regulator
ISA71_RS21565	COG0668	transmembrane transport
ISA71_RS21570	COG0477	Major facilitator Superfamily
ISA71_RS21595	COG0778	Nitroreductase
ISA71_RS21600	COG2315	Protein conserved in bacteria
ISA71_RS21640	COG3698	Phosphodiester glycosidase
ISA71_RS21660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS21665	COG4608	Belongs to the ABC transporter superfamily
ISA71_RS21680	COG0697	spore germination
ISA71_RS21695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ISA71_RS21700	COG0765	amino acid transport
ISA71_RS21705	COG4215	(ABC) transporter
ISA71_RS21715	COG4221	oxidoreductase activity
ISA71_RS21720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA71_RS21730	COG4608	Belongs to the ABC transporter superfamily
ISA71_RS21735	COG0444	Belongs to the ABC transporter superfamily
ISA71_RS21740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA71_RS21745	COG0601	transmembrane transport
ISA71_RS21750	COG0747	negative chemotaxis
ISA71_RS21775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA71_RS21785	COG0668	transmembrane transport
ISA71_RS21790	COG0583	DNA-binding transcription factor activity
ISA71_RS21800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISA71_RS21810	COG3958	Transketolase
ISA71_RS21815	COG3959	Transketolase, thiamine diphosphate binding domain
ISA71_RS21820	COG2390	Transcriptional regulator
ISA71_RS21830	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS21835	COG1129	ABC transporter
ISA71_RS21845	COG1879	ABC-type sugar transport system periplasmic component
ISA71_RS21855	COG4771	TonB-dependent receptor
ISA71_RS21860	COG2382	esterase
ISA71_RS21865	COG3251	PFAM MbtH domain protein
ISA71_RS21870	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ISA71_RS21870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISA71_RS21875	COG1120	ATPase activity
ISA71_RS21880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS21885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA71_RS21895	COG4592	Periplasmic binding protein
ISA71_RS21900	COG1169	isochorismate synthase
ISA71_RS21905	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISA71_RS21910	COG3433	isochorismatase activity
ISA71_RS21910	COG1535	isochorismatase
ISA71_RS21915	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS21925	COG1966	Carbon starvation protein
ISA71_RS21930	COG2879	small protein
ISA71_RS21945	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS21950	COG0371	Dehydrogenase
ISA71_RS21955	COG1129	ABC transporter
ISA71_RS21960	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS21990	COG2271	Major facilitator Superfamily
ISA71_RS21995	COG0483	inositol monophosphate 1-phosphatase activity
ISA71_RS22005	COG0402	S-adenosylhomocysteine deaminase activity
ISA71_RS22015	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA71_RS22030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA71_RS22040	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS22045	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA71_RS22050	COG1129	ABC transporter
ISA71_RS22075	COG0436	Aminotransferase
ISA71_RS22080	COG1475	DNA binding
ISA71_RS22085	COG3969	phosphoadenosine phosphosulfate
ISA71_RS22090	COG0583	DNA-binding transcription factor activity
ISA71_RS22095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISA71_RS22115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA71_RS22120	COG3719	Belongs to the RNase T2 family
ISA71_RS22125	COG3069	C4-dicarboxylate transmembrane transporter activity
ISA71_RS22145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA71_RS22160	COG0583	DNA-binding transcription factor activity
ISA71_RS22175	COG1686	Belongs to the peptidase S11 family
ISA71_RS22180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA71_RS22185	COG0772	Belongs to the SEDS family
ISA71_RS22190	COG0768	penicillin binding
ISA71_RS22200	COG0799	negative regulation of ribosome biogenesis
ISA71_RS22215	COG1466	dna polymerase III delta subunit
ISA71_RS22230	COG2888	peptidyl-tyrosine sulfation
ISA71_RS22245	COG1126	abc transporter atp-binding protein
ISA71_RS22250	COG0765	amino acid transport
ISA71_RS22255	COG0765	amino acid transport
ISA71_RS22280	COG1702	phosphate starvation-inducible protein PhoH
ISA71_RS22290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA71_RS22330	COG0367	asparagine synthase
ISA71_RS22335	COG0647	UMP catabolic process
ISA71_RS22340	COG1846	Transcriptional regulator
ISA71_RS22340	COG1940	carbohydrate kinase activity
ISA71_RS22345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISA71_RS22385	COG0735	belongs to the Fur family
ISA71_RS22400	COG0596	Alpha beta hydrolase
ISA71_RS22410	COG0033	Phosphoglucomutase
ISA71_RS22420	COG0745	RESPONSE REGULATOR receiver
ISA71_RS22425	COG2205	protein histidine kinase activity
ISA71_RS22455	COG0415	Belongs to the DNA photolyase family
ISA71_RS22470	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISA71_RS22475	COG1984	allophanate hydrolase subunit 2
ISA71_RS22510	COG2009	succinate dehydrogenase
ISA71_RS22515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISA71_RS22520	COG1053	succinate dehydrogenase
ISA71_RS22525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA71_RS22530	COG0567	Dehydrogenase, E1 component
ISA71_RS22535	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA71_RS22545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISA71_RS22550	COG1271	oxidase subunit
ISA71_RS22555	COG1294	oxidase, subunit
ISA71_RS22560	COG4890	Cyd operon protein YbgT
ISA71_RS22565	COG3790	cyd operon protein YbgE
ISA71_RS22570	COG0824	Thioesterase
ISA71_RS22575	COG0811	peptide transport
ISA71_RS22580	COG0848	biopolymer transport protein
ISA71_RS22585	COG3064	Membrane
ISA71_RS22595	COG2885	chlorophyll binding
ISA71_RS22600	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISA71_RS22640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISA71_RS22645	COG3201	nicotinamide mononucleotide transporter
ISA71_RS22660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA71_RS22670	COG2017	converts alpha-aldose to the beta-anomer
ISA71_RS22680	COG1085	galactose-1-phosphate uridylyltransferase
ISA71_RS22690	COG1119	ATPase activity
ISA71_RS22695	COG3585	molybdate ion transport
ISA71_RS22695	COG2005	Transcriptional regulator
ISA71_RS22705	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISA71_RS22710	COG4149	molybdate abc transporter
ISA71_RS22720	COG0561	phosphatase activity
ISA71_RS22745	COG2200	EAL domain
ISA71_RS22750	COG0789	Transcriptional regulator
ISA71_RS22785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS22790	COG0589	response to stress
ISA71_RS22800	COG4677	pectinesterase activity
ISA71_RS22840	COG1881	PFAM PEBP family protein
ISA71_RS22845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA71_RS22860	COG2226	methyltransferase
ISA71_RS22885	COG0642	Histidine kinase
ISA71_RS22890	COG0745	RESPONSE REGULATOR receiver
ISA71_RS22910	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA71_RS22920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISA71_RS22925	COG0314	molybdopterin synthase activity
ISA71_RS22930	COG0670	Belongs to the BI1 family
ISA71_RS22935	COG0392	lysyltransferase activity
ISA71_RS22940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA71_RS22945	COG3568	Endonuclease Exonuclease Phosphatase
ISA71_RS22955	COG0842	Transport permease protein
ISA71_RS22960	COG0842	Transport permease protein
ISA71_RS22965	COG1131	(ABC) transporter
ISA71_RS22970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS22975	COG1309	transcriptional regulator
ISA71_RS22980	COG0583	DNA-binding transcription factor activity
ISA71_RS22990	COG2271	Major facilitator Superfamily
ISA71_RS22995	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS23000	COG3959	Transketolase, thiamine diphosphate binding domain
ISA71_RS23005	COG3958	Transketolase
ISA71_RS23010	COG0513	Belongs to the DEAD box helicase family
ISA71_RS23015	COG1199	ATP-dependent helicase activity
ISA71_RS23020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA71_RS23030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISA71_RS23040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA71_RS23050	COG0668	transmembrane transport
ISA71_RS23055	COG1126	abc transporter atp-binding protein
ISA71_RS23060	COG0765	amino acid transport
ISA71_RS23065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS23080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISA71_RS23085	COG2194	sulfuric ester hydrolase activity
ISA71_RS23100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA71_RS23105	COG2723	6-phospho-beta-galactosidase activity
ISA71_RS23110	COG2188	Transcriptional regulator
ISA71_RS23115	COG1376	ErfK ybiS ycfS ynhG family protein
ISA71_RS23120	COG2365	Tyrosine phosphatase family
ISA71_RS23125	COG0488	(ABC) transporter
ISA71_RS23135	COG2271	Major facilitator Superfamily
ISA71_RS23150	COG0561	phosphatase activity
ISA71_RS23155	COG1882	Formate acetyltransferase
ISA71_RS23160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA71_RS23165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA71_RS23170	COG0303	'Molybdopterin
ISA71_RS23185	COG0747	negative chemotaxis
ISA71_RS23205	COG2223	nitrite transmembrane transporter activity
ISA71_RS23215	COG2133	pyrroloquinoline quinone binding
ISA71_RS23220	COG0625	glutathione transferase activity
ISA71_RS23230	COG1686	Belongs to the peptidase S11 family
ISA71_RS23235	COG1349	DNA-binding transcription factor activity
ISA71_RS23240	COG0671	phosphoesterase, PA-phosphatase related
ISA71_RS23245	COG2814	Major facilitator Superfamily
ISA71_RS23250	COG0561	phosphatase activity
ISA71_RS23255	COG0738	Major facilitator superfamily
ISA71_RS23260	COG3226	Transcriptional regulator
ISA71_RS23285	COG0778	Nitroreductase
ISA71_RS23300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA71_RS23305	COG3842	ATPase activity
ISA71_RS23310	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA71_RS23315	COG1177	transmembrane transport
ISA71_RS23330	COG0745	RESPONSE REGULATOR receiver
ISA71_RS23335	COG5002	protein histidine kinase activity
ISA71_RS23340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS23345	COG4160	amino acid transport
ISA71_RS23350	COG4215	(ABC) transporter
ISA71_RS23355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA71_RS23360	COG1126	abc transporter atp-binding protein
ISA71_RS23370	COG5001	Diguanylate cyclase
ISA71_RS23370	COG2203	Gaf domain
ISA71_RS23370	COG4251	negative regulation of phosphorylation
ISA71_RS23370	COG3706	GGDEF domain
ISA71_RS23375	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA71_RS23380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA71_RS23385	COG0702	epimerase
ISA71_RS23390	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISA71_RS23395	COG0028	Belongs to the TPP enzyme family
ISA71_RS23405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA71_RS23415	COG2431	L-lysine efflux transmembrane transporter activity
ISA71_RS23425	COG3593	DNA synthesis involved in DNA repair
ISA71_RS23430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS23440	COG1278	Cold shock
ISA71_RS23450	COG0542	response to heat
ISA71_RS23465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISA71_RS23470	COG4988	ABC transporter
ISA71_RS23475	COG0492	ferredoxin-NADP+ reductase activity
ISA71_RS23485	COG1674	ftsk spoiiie
ISA71_RS23485	COG1178	ABC-type Fe3 transport system permease component
ISA71_RS23495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISA71_RS23505	COG0243	molybdopterin cofactor binding
ISA71_RS23510	COG0437	4 iron, 4 sulfur cluster binding
ISA71_RS23515	COG3302	dmso reductase anchor subunit
ISA71_RS23520	COG0477	Major facilitator Superfamily
ISA71_RS23525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA71_RS23530	COG1882	Formate acetyltransferase
ISA71_RS23535	COG2116	formate transmembrane transporter activity
ISA71_RS23540	COG1944	ATP diphosphatase activity
ISA71_RS23545	COG2323	membrane
ISA71_RS23565	COG0539	negative regulation of cytoplasmic translation
ISA71_RS23575	COG0658	competence protein
ISA71_RS23575	COG2333	competence protein COMEC
ISA71_RS23590	COG3214	Protein conserved in bacteria
ISA71_RS23605	COG3173	Aminoglycoside phosphotransferase
ISA71_RS23610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA71_RS23615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISA71_RS23625	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ISA71_RS23635	COG2989	Protein conserved in bacteria
ISA71_RS23640	COG3108	Peptidase M15
ISA71_RS23645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA71_RS23650	COG1448	Aminotransferase
ISA71_RS23655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA71_RS23675	COG0814	amino acid
ISA71_RS23685	COG1473	amidohydrolase
ISA71_RS23695	COG0308	aminopeptidase N
ISA71_RS23705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA71_RS23710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA71_RS23715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA71_RS23720	COG0431	NADPH-dependent FMN reductase
ISA71_RS23735	COG3217	Mosc domain protein beta barrel domain protein
ISA71_RS23735	COG0633	Ferredoxin
ISA71_RS23745	COG0488	(ABC) transporter
ISA71_RS23750	COG2995	paraquat-inducible protein a
ISA71_RS23755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA71_RS23755	COG3008	intermembrane lipid transfer
ISA71_RS23760	COG3009	Protein conserved in bacteria
ISA71_RS23765	COG3130	regulation of translation
ISA71_RS23775	COG1067	ATP-dependent peptidase activity
ISA71_RS23795	COG3070	regulator of competence-specific genes
ISA71_RS23800	COG1289	transmembrane transporter activity
ISA71_RS23805	COG3304	Inner membrane component domain
ISA71_RS23810	COG0210	DNA helicase
ISA71_RS23820	COG1832	CoA-binding protein
ISA71_RS23835	COG2274	protein secretion by the type I secretion system
ISA71_RS23840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA71_RS23865	COG1881	PFAM PEBP family protein
ISA71_RS23870	COG2207	Transcriptional regulator
ISA71_RS23885	COG0670	Belongs to the BI1 family
ISA71_RS23900	COG0058	SHG alpha-glucan phosphorylase activity
ISA71_RS23910	COG2200	EAL domain
ISA71_RS23930	COG3706	GGDEF domain
ISA71_RS23935	COG2207	Transcriptional regulator
ISA71_RS23945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA71_RS23950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA71_RS23955	COG1882	Formate acetyltransferase
ISA71_RS23960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA71_RS23965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA71_RS23970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS23970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA71_RS23970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA71_RS23975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA71_RS23980	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS23985	COG4638	Rieske (2fe-2S)
ISA71_RS23990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA71_RS23995	COG0473	3-isopropylmalate dehydrogenase activity
ISA71_RS24000	COG0583	DNA-binding transcription factor activity
ISA71_RS24005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA71_RS24010	COG1012	belongs to the aldehyde dehydrogenase family
ISA71_RS24015	COG1917	Cupin 2, conserved barrel domain protein
ISA71_RS24015	COG1396	sequence-specific DNA binding
ISA71_RS24020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISA71_RS24025	COG0174	glutamine synthetase
ISA71_RS24030	COG0531	amino acid
ISA71_RS24045	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS24075	COG3729	General stress protein
ISA71_RS24085	COG2233	PERMEase
ISA71_RS24120	COG1309	transcriptional regulator
ISA71_RS24135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISA71_RS24145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA71_RS24165	COG1702	phosphate starvation-inducible protein PhoH
ISA71_RS24175	COG1335	isochorismatase
ISA71_RS24185	COG0583	DNA-binding transcription factor activity
ISA71_RS24205	COG3381	protein complex oligomerization
ISA71_RS24240	COG5645	(Lipo)protein
ISA71_RS24255	COG1560	Kdo2-lipid A biosynthetic process
ISA71_RS24300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA71_RS24320	COG2814	Major facilitator Superfamily
ISA71_RS24325	COG0583	DNA-binding transcription factor activity
ISA71_RS24330	COG1530	ribonuclease E activity
ISA71_RS24350	COG1399	metal-binding, possibly nucleic acid-binding protein
ISA71_RS24370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA71_RS24385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA71_RS24390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISA71_RS24395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISA71_RS24405	COG0470	DNA polymerase III
ISA71_RS24410	COG0084	hydrolase, TatD family'
ISA71_RS24420	COG0537	adenosine 5'-monophosphoramidase activity
ISA71_RS24425	COG5633	Lipoprotein
ISA71_RS24450	COG1252	NADH dehydrogenase
ISA71_RS24455	COG3134	Outer membrane lipoprotein
ISA71_RS24470	COG1309	transcriptional regulator
ISA71_RS24485	COG1376	ErfK ybiS ycfS ynhG family protein
ISA71_RS24485	COG1388	LysM domain
ISA71_RS24490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISA71_RS24500	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA71_RS24510	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA71_RS24520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISA71_RS24530	COG2390	Transcriptional regulator
ISA71_RS24545	COG3395	kinase activity
ISA71_RS24560	COG0698	ribose 5-phosphate isomerase
ISA71_RS24565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA71_RS24570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA71_RS24575	COG0318	PFAM AMP-dependent synthetase and ligase
ISA71_RS24590	COG1177	transmembrane transport
ISA71_RS24610	COG2850	peptidyl-arginine hydroxylation
ISA71_RS24615	COG2205	protein histidine kinase activity
ISA71_RS24635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISA71_RS24655	COG1187	pseudouridine synthase activity
ISA71_RS24660	COG0538	isocitrate dehydrogenase activity
ISA71_RS24665	COG0582	viral genome integration into host DNA
ISA71_RS24675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA71_RS24740	COG1403	HNH endonuclease
ISA71_RS24765	COG3772	lysozyme
ISA71_RS24810	COG1802	Transcriptional regulator
ISA71_RS24810	COG4626	Terminase
ISA71_RS24825	COG0616	signal peptide processing
ISA71_RS24910	COG3706	GGDEF domain
ISA71_RS24915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA71_RS24920	COG0538	isocitrate dehydrogenase activity
ISA71_RS24925	COG0640	Transcriptional regulator
ISA71_RS24945	COG3813	Protein conserved in bacteria
ISA71_RS24950	COG1063	alcohol dehydrogenase
ISA71_RS24955	COG3729	General stress protein
ISA71_RS24960	COG3685	Protein conserved in bacteria
ISA71_RS24965	COG3685	Protein conserved in bacteria
ISA71_RS24970	COG3546	catalase activity
ISA71_RS24975	COG1271	oxidase subunit
ISA71_RS24980	COG1294	oxidase, subunit
ISA71_RS25010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA71_RS25015	COG0583	DNA-binding transcription factor activity
ISA71_RS25020	COG3706	GGDEF domain
ISA71_RS25025	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISA71_RS25035	COG1560	Kdo2-lipid A biosynthetic process
ISA71_RS25045	COG3182	Iron-regulated membrane protein
ISA71_RS25065	COG2199	diguanylate cyclase activity
ISA71_RS25065	COG2203	Gaf domain
ISA71_RS25070	COG3042	response to heat
ISA71_RS25075	COG3189	MarR family transcriptional regulator
ISA71_RS25080	COG1683	Conserved Protein
ISA71_RS25085	COG0504	CTP synthase activity
ISA71_RS25090	COG2807	transmembrane transport
ISA71_RS25095	COG2207	Transcriptional regulator
ISA71_RS25105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA71_RS25110	COG0859	PFAM glycosyl transferase family 9
ISA71_RS25120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISA71_RS25125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISA71_RS25130	COG0583	DNA-binding transcription factor activity
ISA71_RS25135	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS25160	COG0386	Belongs to the glutathione peroxidase family
ISA71_RS25175	COG2766	serine protein kinase
ISA71_RS25180	COG3713	MltA-interacting MipA family protein
ISA71_RS25185	COG0656	L-ascorbic acid biosynthetic process
ISA71_RS25205	COG3139	Protein of unknown function (DUF1315)
ISA71_RS25220	COG1335	isochorismatase
ISA71_RS25225	COG0252	asparaginase activity
ISA71_RS25230	COG0616	signal peptide processing
ISA71_RS25235	COG0778	Nitroreductase
ISA71_RS25250	COG0709	Synthesizes selenophosphate from selenide and ATP
ISA71_RS25255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISA71_RS25260	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS25260	COG0604	alcohol dehydrogenase
ISA71_RS25260	COG3321	synthase
ISA71_RS25265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA71_RS25270	COG0494	nUDIX hydrolase
ISA71_RS25275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISA71_RS25280	COG2897	thiosulfate sulfurtransferase activity
ISA71_RS25285	COG4136	ATPase activity
ISA71_RS25290	COG4135	transport system, permease component
ISA71_RS25295	COG4134	Bacterial extracellular solute-binding protein
ISA71_RS25300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA71_RS25305	COG0398	Pfam SNARE associated Golgi protein
ISA71_RS25310	COG0398	Pfam SNARE associated Golgi protein
ISA71_RS25315	COG0708	Exodeoxyribonuclease III
ISA71_RS25325	COG3138	arginine N-succinyltransferase
ISA71_RS25335	COG3724	N-succinylarginine dihydrolase activity
ISA71_RS25345	COG3678	ATP-independent chaperone mediated protein folding
ISA71_RS25350	COG0322	excinuclease ABC activity
ISA71_RS25360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA71_RS25365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS25375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA71_RS25380	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA71_RS25385	COG1917	Cupin 2, conserved barrel domain protein
ISA71_RS25385	COG2169	Transcriptional regulator
ISA71_RS25390	COG1486	melibiose metabolic process
ISA71_RS25400	COG0753	catalase activity
ISA71_RS25410	COG1823	symporter activity
ISA71_RS25415	COG1988	membrane-bound metal-dependent
ISA71_RS25420	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS25425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA71_RS25455	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISA71_RS25460	COG3047	cAMP biosynthetic process
ISA71_RS25470	COG4774	siderophore transport
ISA71_RS25525	COG0134	indole-3-glycerol-phosphate synthase activity
ISA71_RS25525	COG0135	phosphoribosylanthranilate isomerase activity
ISA71_RS25530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA71_RS25530	COG0512	Glutamine amidotransferase of anthranilate synthase
ISA71_RS25535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISA71_RS25545	COG0009	L-threonylcarbamoyladenylate synthase
ISA71_RS25555	COG0583	DNA-binding transcription factor activity
ISA71_RS25565	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISA71_RS25570	COG1028	Short-chain dehydrogenase reductase Sdr
ISA71_RS25580	COG0616	signal peptide processing
ISA71_RS25605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISA71_RS25615	COG0671	phosphoesterase, PA-phosphatase related
ISA71_RS25620	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISA71_RS25625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISA71_RS25635	COG0023	Translation Initiation Factor
ISA71_RS25645	COG1349	DNA-binding transcription factor activity
ISA71_RS25660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA71_RS25660	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA71_RS25665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISA71_RS25675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA71_RS25690	COG4171	peptide transport system, permease
ISA71_RS25760	COG3756	Protein conserved in bacteria
ISA71_RS25845	COG3179	chitinase
ISA71_RS25870	COG5484	DNA packaging
ISA71_RS25870	COG3728	DNA packaging
ISA71_RS25960	COG1196	nuclear chromosome segregation
ISA71_RS26020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISA71_RS26040	COG2135	peptidase activity
ISA71_RS26415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISA71_RS26430	COG0741	lytic transglycosylase activity
ISA71_RS26475	COG2805	Type II/IV secretion system protein
ISA71_RS26565	COG0840	transmembrane signaling receptor activity
ISA71_RS26690	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ISA71_RS26890	COG3328	transposase activity
ISA71_RS26895	COG5499	transcription regulator containing HTH domain
ISA71_RS26965	COG1475	DNA binding
ISA71_RS27060	COG3344	reverse transcriptase
ISA71_RS27080	COG1192	Involved in chromosome partitioning
ISA71_RS27145	COG5290	Psort location Cytoplasmic, score
ISA71_RS27185	COG2801	Transposase and inactivated derivatives
ISA71_RS27195	COG3064	Membrane
ISA71_RS27210	COG3477	response to acidic pH
ISA71_RS27225	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISA71_RS27230	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins