locus-tag	class	description
ISA62_RS00005	COG0583	DNA-binding transcription factor activity
ISA62_RS00025	COG2116	formate transmembrane transporter activity
ISA62_RS00030	COG2853	Lipoprotein
ISA62_RS00040	COG3691	Protein conserved in bacteria
ISA62_RS00055	COG2062	phosphohistidine phosphatase, SixA
ISA62_RS00080	COG0730	response to heat
ISA62_RS00085	COG3101	peptidyl-lysine hydroxylation
ISA62_RS00100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA62_RS00120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA62_RS00130	COG0586	Pfam SNARE associated Golgi protein
ISA62_RS00140	COG0285	dihydrofolate synthase activity
ISA62_RS00145	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISA62_RS00150	COG1286	toxin biosynthetic process
ISA62_RS00155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISA62_RS00160	COG0163	prenyltransferase activity
ISA62_RS00185	COG4160	amino acid transport
ISA62_RS00190	COG4598	ABC transporter
ISA62_RS00205	COG1090	epimerase
ISA62_RS00210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA62_RS00215	COG0625	glutathione transferase activity
ISA62_RS00220	COG0625	glutathione transferase activity
ISA62_RS00225	COG0622	Phosphoesterase
ISA62_RS00230	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISA62_RS00235	COG0280	phosphate acetyltransferase
ISA62_RS00235	COG0857	belongs to the CobB CobQ family
ISA62_RS00255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA62_RS00260	COG0490	domain, Protein
ISA62_RS00260	COG0471	metal ion transport
ISA62_RS00270	COG0436	Aminotransferase
ISA62_RS00275	COG0583	DNA-binding transcription factor activity
ISA62_RS00320	COG0839	Belongs to the complex I subunit 6 family
ISA62_RS00335	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA62_RS00350	COG2153	protein acetylation
ISA62_RS00355	COG1169	isochorismate synthase
ISA62_RS00380	COG0318	PFAM AMP-dependent synthetase and ligase
ISA62_RS00390	COG5464	transposase or invertase
ISA62_RS00405	COG1414	Transcriptional regulator
ISA62_RS00415	COG2271	Major facilitator Superfamily
ISA62_RS00425	COG0247	lactate metabolic process
ISA62_RS00435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA62_RS00440	COG2271	Major facilitator Superfamily
ISA62_RS00445	COG0584	glycerophosphoryl diester phosphodiesterase
ISA62_RS00450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA62_RS00475	COG2205	protein histidine kinase activity
ISA62_RS00475	COG0784	Response regulator, receiver
ISA62_RS00485	COG2198	Histidine kinase
ISA62_RS00485	COG0642	Histidine kinase
ISA62_RS00500	COG2169	Transcriptional regulator
ISA62_RS00500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA62_RS00505	COG3145	DNA-N1-methyladenine dioxygenase activity
ISA62_RS00510	COG4615	Cyclic peptide transporter
ISA62_RS00515	COG2239	Acts as a magnesium transporter
ISA62_RS00520	COG0659	secondary active sulfate transmembrane transporter activity
ISA62_RS00535	COG0628	permease
ISA62_RS00560	COG1349	DNA-binding transcription factor activity
ISA62_RS00565	COG0494	nUDIX hydrolase
ISA62_RS00585	COG1061	Type III restriction enzyme res subunit
ISA62_RS00590	COG1187	pseudouridine synthase activity
ISA62_RS00595	COG2814	Major facilitator Superfamily
ISA62_RS00605	COG4172	Belongs to the ABC transporter superfamily
ISA62_RS00610	COG4239	(ABC) transporter, permease
ISA62_RS00615	COG4174	ABC transporter (Permease)
ISA62_RS00620	COG4166	transmembrane transport
ISA62_RS00625	COG2200	EAL domain
ISA62_RS00630	COG0791	NLP P60 protein
ISA62_RS00635	COG0671	phosphoesterase, PA-phosphatase related
ISA62_RS00640	COG0523	cobalamin synthesis protein
ISA62_RS00645	COG0246	Mannitol dehydrogenase
ISA62_RS00650	COG1312	Catalyzes the dehydration of D-mannonate
ISA62_RS00680	COG0497	DNA recombination
ISA62_RS00715	COG2814	Major facilitator Superfamily
ISA62_RS00720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS00720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS00725	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA62_RS00730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS00730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISA62_RS00730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS00740	COG2855	membrane
ISA62_RS00745	COG0583	DNA-binding transcription factor activity
ISA62_RS00750	COG0833	amino acid
ISA62_RS00755	COG4771	TonB-dependent receptor
ISA62_RS00770	COG2311	Membrane
ISA62_RS00785	COG1129	ABC transporter
ISA62_RS00795	COG2949	membrane
ISA62_RS00805	COG1346	cytolysis
ISA62_RS00815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA62_RS00820	COG3659	wide pore channel activity
ISA62_RS00835	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS00845	COG1538	Outer membrane efflux protein
ISA62_RS00850	COG0586	Pfam SNARE associated Golgi protein
ISA62_RS00860	COG1686	Belongs to the peptidase S11 family
ISA62_RS00875	COG0277	FAD linked oxidase domain protein
ISA62_RS00880	COG1472	Belongs to the glycosyl hydrolase 3 family
ISA62_RS00885	COG1732	Glycine betaine
ISA62_RS00890	COG1174	glycine betaine transport
ISA62_RS00895	COG1125	glycine betaine transport
ISA62_RS00900	COG1174	glycine betaine transport
ISA62_RS00910	COG3275	phosphorelay sensor kinase activity
ISA62_RS00920	COG4807	Protein conserved in bacteria
ISA62_RS00940	COG5455	response to cobalt ion
ISA62_RS00945	COG0583	DNA-binding transcription factor activity
ISA62_RS00950	COG2252	PERMEase
ISA62_RS00960	COG0583	DNA-binding transcription factor activity
ISA62_RS00975	COG0351	phosphomethylpyrimidine kinase
ISA62_RS00980	COG1830	Aldolase
ISA62_RS01015	COG1070	Carbohydrate kinase
ISA62_RS01025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA62_RS01035	COG0826	peptidase U32
ISA62_RS01040	COG0745	RESPONSE REGULATOR receiver
ISA62_RS01045	COG2205	protein histidine kinase activity
ISA62_RS01070	COG1301	dicarboxylic acid transport
ISA62_RS01090	COG5002	protein histidine kinase activity
ISA62_RS01095	COG0443	Heat shock 70 kDa protein
ISA62_RS01100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISA62_RS01115	COG2982	Protein involved in outer membrane biogenesis
ISA62_RS01120	COG1253	flavin adenine dinucleotide binding
ISA62_RS01155	COG0438	transferase activity, transferring glycosyl groups
ISA62_RS01160	COG1216	Glycosyl transferase, family 2
ISA62_RS01185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ISA62_RS01275	COG0438	transferase activity, transferring glycosyl groups
ISA62_RS01280	COG1215	transferase activity, transferring glycosyl groups
ISA62_RS01300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISA62_RS01330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA62_RS01335	COG0583	DNA-binding transcription factor activity
ISA62_RS01345	COG0531	amino acid
ISA62_RS01350	COG0640	Transcriptional regulator
ISA62_RS01355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISA62_RS01360	COG2925	Exonuclease
ISA62_RS01380	COG1289	transmembrane transporter activity
ISA62_RS01400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ISA62_RS01410	COG1942	4-Oxalocrotonate Tautomerase
ISA62_RS01415	COG0583	DNA-binding transcription factor activity
ISA62_RS01420	COG0095	Lipoate-protein ligase
ISA62_RS01425	COG0477	Major facilitator Superfamily
ISA62_RS01435	COG5001	Diguanylate cyclase
ISA62_RS01435	COG3300	MHYT domain
ISA62_RS01445	COG3615	Tellurite resistance protein tehB
ISA62_RS01470	COG3706	GGDEF domain
ISA62_RS01485	COG0534	Mate efflux family protein
ISA62_RS01495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISA62_RS01515	COG0604	alcohol dehydrogenase
ISA62_RS01520	COG1309	transcriptional regulator
ISA62_RS01525	COG0025	NhaP-type Na H and K H
ISA62_RS01560	COG0251	oxidation-reduction process
ISA62_RS01580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA62_RS01590	COG1418	mRNA catabolic process
ISA62_RS01595	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISA62_RS01600	COG3727	T/G mismatch-specific endonuclease activity
ISA62_RS01605	COG0697	spore germination
ISA62_RS01610	COG2354	Protein conserved in bacteria
ISA62_RS01640	COG0366	Alpha amylase catalytic
ISA62_RS01645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS01655	COG0765	amino acid transport
ISA62_RS01660	COG1126	abc transporter atp-binding protein
ISA62_RS01665	COG2197	response regulator
ISA62_RS01675	COG2197	response regulator
ISA62_RS01710	COG3318	Belongs to the UPF0149 family
ISA62_RS01710	COG3012	SEC-C Motif Domain Protein
ISA62_RS01715	COG0814	amino acid
ISA62_RS01725	COG1528	Iron-storage protein
ISA62_RS01740	COG0477	Major facilitator Superfamily
ISA62_RS01750	COG2211	Major facilitator Superfamily
ISA62_RS01760	COG1528	Iron-storage protein
ISA62_RS01770	COG1879	ABC-type sugar transport system periplasmic component
ISA62_RS01780	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS01805	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISA62_RS01815	COG3102	Protein conserved in bacteria
ISA62_RS01835	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISA62_RS01840	COG1801	Protein of unknown function DUF72
ISA62_RS01845	COG1335	isochorismatase
ISA62_RS01855	COG0494	nUDIX hydrolase
ISA62_RS01880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA62_RS01890	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISA62_RS01895	COG0739	heme binding
ISA62_RS01900	COG1560	Kdo2-lipid A biosynthetic process
ISA62_RS01910	COG1737	Transcriptional regulator
ISA62_RS01920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISA62_RS01925	COG0129	dihydroxy-acid dehydratase activity
ISA62_RS01930	COG0800	Aldolase
ISA62_RS01940	COG3141	response to X-ray
ISA62_RS01945	COG2979	Protein of unknown function (DUF533)
ISA62_RS01950	COG1770	oligopeptidase
ISA62_RS01955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA62_RS01965	COG2372	response to copper ion
ISA62_RS01970	COG1276	copper resistance
ISA62_RS01985	COG2990	Protein conserved in bacteria
ISA62_RS02010	COG3008	intermembrane lipid transfer
ISA62_RS02015	COG2995	paraquat-inducible protein a
ISA62_RS02020	COG1956	GAF domain-containing protein
ISA62_RS02040	COG2814	Major facilitator Superfamily
ISA62_RS02045	COG1414	Transcriptional regulator
ISA62_RS02080	COG2226	methyltransferase
ISA62_RS02095	COG3716	PTS system mannose fructose sorbose family IID component
ISA62_RS02100	COG3715	PTS system
ISA62_RS02105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS02105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA62_RS02110	COG1253	flavin adenine dinucleotide binding
ISA62_RS02115	COG2200	EAL domain
ISA62_RS02120	COG1760	l-serine dehydratase
ISA62_RS02140	COG0251	oxidation-reduction process
ISA62_RS02145	COG1199	ATP-dependent helicase activity
ISA62_RS02155	COG3065	identical protein binding
ISA62_RS02165	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISA62_RS02175	COG2894	cell division
ISA62_RS02190	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA62_RS02220	COG2719	SpoVR family
ISA62_RS02245	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISA62_RS02255	COG4774	siderophore transport
ISA62_RS02270	COG2308	Evidence 4 Homologs of previously reported genes of
ISA62_RS02310	COG0583	DNA-binding transcription factor activity
ISA62_RS02315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA62_RS02330	COG1882	Formate acetyltransferase
ISA62_RS02365	COG0583	DNA-binding transcription factor activity
ISA62_RS02395	COG0583	DNA-binding transcription factor activity
ISA62_RS02410	COG3122	Protein conserved in bacteria
ISA62_RS02430	COG2885	chlorophyll binding
ISA62_RS02445	COG1388	LysM domain
ISA62_RS02510	COG0012	GTP binding
ISA62_RS02530	COG0659	secondary active sulfate transmembrane transporter activity
ISA62_RS02560	COG2890	protein-(glutamine-N5) methyltransferase activity
ISA62_RS02580	COG0387	Pfam Sodium calcium exchanger
ISA62_RS02585	COG4572	Cation transport regulator
ISA62_RS02590	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ISA62_RS02600	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISA62_RS02605	COG3707	response regulator
ISA62_RS02610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA62_RS02620	COG1116	anion transmembrane transporter activity
ISA62_RS02625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA62_RS02625	COG2146	nitrite reductase [NAD(P)H] activity
ISA62_RS02630	COG0243	molybdopterin cofactor binding
ISA62_RS02635	COG4932	domain protein
ISA62_RS02640	COG2197	response regulator
ISA62_RS02645	COG3850	Histidine kinase
ISA62_RS02650	COG2223	nitrite transmembrane transporter activity
ISA62_RS02660	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA62_RS02665	COG1140	nitrate reductase beta subunit
ISA62_RS02670	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA62_RS02675	COG2181	nitrate reductase activity
ISA62_RS02685	COG1522	sequence-specific DNA binding
ISA62_RS02725	COG0788	formyltetrahydrofolate deformylase activity
ISA62_RS02735	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISA62_RS02740	COG0745	RESPONSE REGULATOR receiver
ISA62_RS02745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISA62_RS02750	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA62_RS02760	COG1435	thymidine kinase activity
ISA62_RS02765	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS02765	COG1454	alcohol dehydrogenase
ISA62_RS02775	COG2095	MarC family integral membrane protein
ISA62_RS02780	COG4166	transmembrane transport
ISA62_RS02785	COG0601	transmembrane transport
ISA62_RS02790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA62_RS02795	COG0444	Belongs to the ABC transporter superfamily
ISA62_RS02805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA62_RS02825	COG2353	YceI-like domain
ISA62_RS02835	COG2350	Protein conserved in bacteria
ISA62_RS02845	COG3001	Fructosamine kinase
ISA62_RS02855	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA62_RS02860	COG3137	Salt-induced outer membrane protein
ISA62_RS02900	COG0072	phenylalanine-tRNA ligase activity
ISA62_RS02900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISA62_RS02920	COG0583	DNA-binding transcription factor activity
ISA62_RS02940	COG0386	Belongs to the glutathione peroxidase family
ISA62_RS02950	COG0791	NLP P60 protein
ISA62_RS02960	COG4256	Hemin uptake protein
ISA62_RS02965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA62_RS02980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA62_RS02980	COG0574	Belongs to the PEP-utilizing enzyme family
ISA62_RS02990	COG0628	permease
ISA62_RS02995	COG0277	FAD linked oxidase domain protein
ISA62_RS02995	COG0247	lactate metabolic process
ISA62_RS03000	COG2050	protein possibly involved in aromatic compounds catabolism
ISA62_RS03005	COG2261	transglycosylase associated protein
ISA62_RS03030	COG1120	ATPase activity
ISA62_RS03035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS03045	COG0583	DNA-binding transcription factor activity
ISA62_RS03070	COG1304	FMN binding
ISA62_RS03075	COG1309	transcriptional regulator
ISA62_RS03095	COG0316	Belongs to the HesB IscA family
ISA62_RS03100	COG0719	Fe-S assembly protein
ISA62_RS03105	COG0396	ATPase activity
ISA62_RS03110	COG0719	Fe-S assembly protein
ISA62_RS03125	COG1376	ErfK ybiS ycfS ynhG family protein
ISA62_RS03155	COG1309	transcriptional regulator
ISA62_RS03160	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ISA62_RS03160	COG1082	Xylose isomerase domain protein TIM barrel
ISA62_RS03165	COG2271	Major facilitator Superfamily
ISA62_RS03170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA62_RS03180	COG1120	ATPase activity
ISA62_RS03185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS03190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA62_RS03195	COG1414	Transcriptional regulator
ISA62_RS03230	COG2814	Major facilitator Superfamily
ISA62_RS03250	COG0583	DNA-binding transcription factor activity
ISA62_RS03255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA62_RS03275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA62_RS03280	COG1116	anion transmembrane transporter activity
ISA62_RS03285	COG4774	siderophore transport
ISA62_RS03290	COG1120	ATPase activity
ISA62_RS03295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS03300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS03395	COG3383	formate dehydrogenase (NAD+) activity
ISA62_RS03400	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ISA62_RS03410	COG1175	transmembrane transport
ISA62_RS03445	COG4133	protoheme IX ABC transporter activity
ISA62_RS03450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA62_RS03455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA62_RS03470	COG1138	Cytochrome C-type biogenesis protein
ISA62_RS03475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA62_RS03480	COG4235	cytochrome complex assembly
ISA62_RS03480	COG3088	subunit of a heme lyase
ISA62_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS03540	COG2610	gluconate transmembrane transporter activity
ISA62_RS03545	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA62_RS03555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA62_RS03565	COG0583	DNA-binding transcription factor activity
ISA62_RS03585	COG0277	FAD linked oxidase domain protein
ISA62_RS03590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA62_RS03615	COG0402	S-adenosylhomocysteine deaminase activity
ISA62_RS03665	COG2200	EAL domain
ISA62_RS03675	COG0745	RESPONSE REGULATOR receiver
ISA62_RS03680	COG2205	protein histidine kinase activity
ISA62_RS03685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS03715	COG2814	Major facilitator Superfamily
ISA62_RS03720	COG1082	Xylose isomerase domain protein TIM barrel
ISA62_RS03730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS03765	COG4608	Belongs to the ABC transporter superfamily
ISA62_RS03770	COG0444	Belongs to the ABC transporter superfamily
ISA62_RS03795	COG0346	lactoylglutathione lyase activity
ISA62_RS03800	COG1349	DNA-binding transcription factor activity
ISA62_RS03835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISA62_RS03890	COG0307	riboflavin synthase, alpha
ISA62_RS03895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA62_RS03900	COG2814	Major facilitator Superfamily
ISA62_RS03905	COG0583	DNA-binding transcription factor activity
ISA62_RS03920	COG2814	Major facilitator Superfamily
ISA62_RS03935	COG0791	NLP P60 protein
ISA62_RS03940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISA62_RS03950	COG0346	lactoylglutathione lyase activity
ISA62_RS03955	COG1902	pentaerythritol trinitrate reductase activity
ISA62_RS03960	COG1309	transcriptional regulator
ISA62_RS03965	COG3313	Fe-S protein
ISA62_RS03970	COG4989	oxidoreductase activity
ISA62_RS03975	COG2032	superoxide dismutase activity
ISA62_RS03980	COG1289	transmembrane transporter activity
ISA62_RS03985	COG1566	PFAM secretion protein HlyD family protein
ISA62_RS04000	COG3706	GGDEF domain
ISA62_RS04015	COG3895	Periplasmic Protein
ISA62_RS04030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISA62_RS04035	COG0625	glutathione transferase activity
ISA62_RS04045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISA62_RS04055	COG4659	FMN binding
ISA62_RS04090	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS04100	COG0673	inositol 2-dehydrogenase activity
ISA62_RS04110	COG2814	Major facilitator Superfamily
ISA62_RS04130	COG3038	cytochrome b561
ISA62_RS04150	COG0583	DNA-binding transcription factor activity
ISA62_RS04155	COG3485	protocatechuate 3,4-dioxygenase
ISA62_RS04160	COG3485	protocatechuate 3,4-dioxygenase
ISA62_RS04165	COG5383	Protein conserved in bacteria
ISA62_RS04170	COG2272	Belongs to the type-B carboxylesterase lipase family
ISA62_RS04185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA62_RS04190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA62_RS04195	COG1275	C4-dicarboxylate transporter malic acid transport protein
ISA62_RS04200	COG0500	methyltransferase
ISA62_RS04215	COG3708	Transcriptional regulator
ISA62_RS04215	COG2207	Transcriptional regulator
ISA62_RS04220	COG3135	benzoate transporter
ISA62_RS04225	COG1396	sequence-specific DNA binding
ISA62_RS04235	COG0826	peptidase U32
ISA62_RS04255	COG1294	oxidase, subunit
ISA62_RS04260	COG1271	oxidase subunit
ISA62_RS04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA62_RS04270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA62_RS04275	COG3842	ATPase activity
ISA62_RS04280	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA62_RS04285	COG1177	transmembrane transport
ISA62_RS04290	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS04325	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS04330	COG0747	negative chemotaxis
ISA62_RS04340	COG3238	Protein conserved in bacteria
ISA62_RS04345	COG1247	-acetyltransferase
ISA62_RS04355	COG2130	NADP-dependent
ISA62_RS04370	COG3691	Protein conserved in bacteria
ISA62_RS04375	COG1228	amidohydrolase
ISA62_RS04380	COG4772	TonB-dependent receptor
ISA62_RS04405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA62_RS04410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA62_RS04415	COG1473	amidohydrolase
ISA62_RS04420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA62_RS04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS04435	COG0765	amino acid transport
ISA62_RS04440	COG1126	abc transporter atp-binding protein
ISA62_RS04450	COG0625	glutathione transferase activity
ISA62_RS04475	COG2211	Major facilitator Superfamily
ISA62_RS04490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA62_RS04495	COG3842	ATPase activity
ISA62_RS04500	COG1840	ABC-type Fe3 transport system, periplasmic component
ISA62_RS04505	COG1178	ABC-type Fe3 transport system permease component
ISA62_RS04510	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ISA62_RS04515	COG2181	nitrate reductase activity
ISA62_RS04520	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA62_RS04525	COG1140	nitrate reductase beta subunit
ISA62_RS04530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA62_RS04550	COG1414	Transcriptional regulator
ISA62_RS04555	COG4948	Mandelate Racemase Muconate Lactonizing
ISA62_RS04560	COG4829	muconolactone delta-isomerase
ISA62_RS04565	COG3485	protocatechuate 3,4-dioxygenase
ISA62_RS04575	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ISA62_RS04600	COG0437	4 iron, 4 sulfur cluster binding
ISA62_RS04605	COG2864	formate dehydrogenase
ISA62_RS04620	COG2326	polyphosphate kinase activity
ISA62_RS04630	COG2814	Major facilitator Superfamily
ISA62_RS04640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA62_RS04650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA62_RS04660	COG0747	negative chemotaxis
ISA62_RS04680	COG0488	(ABC) transporter
ISA62_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS04725	COG3729	General stress protein
ISA62_RS04735	COG3685	Protein conserved in bacteria
ISA62_RS04745	COG0366	Alpha amylase catalytic
ISA62_RS04755	COG2323	membrane
ISA62_RS04765	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA62_RS04775	COG1764	response to oxidative stress
ISA62_RS04800	COG3781	membrane
ISA62_RS04805	COG0243	molybdopterin cofactor binding
ISA62_RS04810	COG0583	DNA-binding transcription factor activity
ISA62_RS04815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS04840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS04845	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA62_RS04850	COG2814	Major facilitator Superfamily
ISA62_RS04855	COG1285	pathogenesis
ISA62_RS04860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA62_RS04870	COG0583	DNA-binding transcription factor activity
ISA62_RS04890	COG0519	Catalyzes the synthesis of GMP from XMP
ISA62_RS04890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISA62_RS04930	COG0596	Alpha beta hydrolase
ISA62_RS04940	COG2205	protein histidine kinase activity
ISA62_RS04955	COG0076	glutamate decarboxylase activity
ISA62_RS04960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA62_RS04965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA62_RS04970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA62_RS04975	COG1116	anion transmembrane transporter activity
ISA62_RS04980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISA62_RS04995	COG0673	inositol 2-dehydrogenase activity
ISA62_RS05005	COG1609	Transcriptional regulator
ISA62_RS05010	COG3706	GGDEF domain
ISA62_RS05015	COG0402	S-adenosylhomocysteine deaminase activity
ISA62_RS05020	COG1953	Uracil, thiamine, allantoin
ISA62_RS05060	COG0406	alpha-ribazole phosphatase activity
ISA62_RS05065	COG1335	isochorismatase
ISA62_RS05080	COG2207	Transcriptional regulator
ISA62_RS05095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA62_RS05165	COG0765	amino acid transport
ISA62_RS05175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISA62_RS05185	COG2070	2-Nitropropane dioxygenase
ISA62_RS05190	COG0583	DNA-binding transcription factor activity
ISA62_RS05200	COG1902	pentaerythritol trinitrate reductase activity
ISA62_RS05205	COG4529	Protein conserved in bacteria
ISA62_RS05210	COG0477	Major facilitator Superfamily
ISA62_RS05235	COG2223	nitrite transmembrane transporter activity
ISA62_RS05245	COG1609	Transcriptional regulator
ISA62_RS05250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS05260	COG3037	sugar-specific permease SgaT UlaA
ISA62_RS05265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA62_RS05275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS05280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS05280	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISA62_RS05280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS05290	COG2197	response regulator
ISA62_RS05315	COG3039	Transposase
ISA62_RS05345	COG0583	DNA-binding transcription factor activity
ISA62_RS05350	COG0583	DNA-binding transcription factor activity
ISA62_RS05355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA62_RS05365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA62_RS05380	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS05390	COG1609	Transcriptional regulator
ISA62_RS05420	COG1652	LysM domain
ISA62_RS05445	COG0456	acetyltransferase
ISA62_RS05445	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISA62_RS05455	COG0667	Aldo Keto reductase
ISA62_RS05460	COG0667	Aldo Keto reductase
ISA62_RS05465	COG3386	PFAM SMP-30 Gluconolaconase
ISA62_RS05470	COG0667	Aldo Keto reductase
ISA62_RS05480	COG1349	DNA-binding transcription factor activity
ISA62_RS05495	COG1349	DNA-binding transcription factor activity
ISA62_RS05500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA62_RS05505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS05510	COG0738	Major facilitator superfamily
ISA62_RS05555	COG1929	Belongs to the glycerate kinase type-1 family
ISA62_RS05560	COG3835	regulator
ISA62_RS05565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ISA62_RS05570	COG0583	DNA-binding transcription factor activity
ISA62_RS05580	COG2186	Transcriptional regulator
ISA62_RS05585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA62_RS05585	COG1263	PTS System
ISA62_RS05595	COG2814	Major facilitator Superfamily
ISA62_RS05600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS05600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS05615	COG2819	hydrolase of the alpha beta superfamily
ISA62_RS05620	COG5001	Diguanylate cyclase
ISA62_RS05620	COG3300	MHYT domain
ISA62_RS05655	COG3188	usher protein
ISA62_RS05665	COG1649	PFAM Uncharacterised BCR, COG1649
ISA62_RS05670	COG3550	peptidyl-serine autophosphorylation
ISA62_RS05675	COG1396	sequence-specific DNA binding
ISA62_RS05680	COG2351	hydroxyisourate hydrolase activity
ISA62_RS05685	COG3195	allantoin biosynthetic process
ISA62_RS05685	COG3648	Uricase
ISA62_RS05690	COG2233	PERMEase
ISA62_RS05720	COG2207	Transcriptional regulator
ISA62_RS05745	COG2842	Transposition protein
ISA62_RS05775	COG4382	Mu-like prophage protein Gp16
ISA62_RS05815	COG0640	Transcriptional regulator
ISA62_RS05830	COG4373	Mu-like prophage FluMu protein gp28
ISA62_RS05855	COG4397	Mu-like prophage major head subunit gpT
ISA62_RS05885	COG4386	tail sheath protein
ISA62_RS05895	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
ISA62_RS05915	COG4384	Bacteriophage Mu Gp45 protein
ISA62_RS05925	COG3299	homolog of phage Mu protein gp47
ISA62_RS05935	COG5301	cellulose 1,4-beta-cellobiosidase activity
ISA62_RS05940	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISA62_RS05960	COG4628	conserved protein (DUF2132)
ISA62_RS05980	COG2011	ABC-type metal ion transport system permease component
ISA62_RS05985	COG2070	2-Nitropropane dioxygenase
ISA62_RS05995	COG0477	Major facilitator Superfamily
ISA62_RS06060	COG2199	diguanylate cyclase activity
ISA62_RS06075	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS06080	COG0583	DNA-binding transcription factor activity
ISA62_RS06090	COG0039	L-malate dehydrogenase activity
ISA62_RS06095	COG1349	DNA-binding transcription factor activity
ISA62_RS06100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA62_RS06105	COG3395	kinase activity
ISA62_RS06115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA62_RS06120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA62_RS06125	COG2271	Major facilitator Superfamily
ISA62_RS06155	COG4977	sequence-specific DNA binding
ISA62_RS06165	COG0697	spore germination
ISA62_RS06170	COG2814	Major facilitator Superfamily
ISA62_RS06205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISA62_RS06240	COG2223	nitrite transmembrane transporter activity
ISA62_RS06245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISA62_RS06260	COG1349	DNA-binding transcription factor activity
ISA62_RS06265	COG2084	Dehydrogenase
ISA62_RS06270	COG3395	kinase activity
ISA62_RS06275	COG0235	Class ii aldolase
ISA62_RS06280	COG3622	Belongs to the hyi family
ISA62_RS06285	COG2610	gluconate transmembrane transporter activity
ISA62_RS06290	COG2207	Transcriptional regulator
ISA62_RS06290	COG3708	Transcriptional regulator
ISA62_RS06305	COG2200	EAL domain
ISA62_RS06310	COG1546	Belongs to the CinA family
ISA62_RS06315	COG0071	Belongs to the small heat shock protein (HSP20) family
ISA62_RS06330	COG2197	response regulator
ISA62_RS06345	COG2135	peptidase activity
ISA62_RS06350	COG2207	Transcriptional regulator
ISA62_RS06365	COG4221	oxidoreductase activity
ISA62_RS06370	COG1802	Transcriptional regulator
ISA62_RS06375	COG0589	response to stress
ISA62_RS06385	COG2271	Major facilitator Superfamily
ISA62_RS06400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA62_RS06415	COG0243	molybdopterin cofactor binding
ISA62_RS06420	COG0437	4 iron, 4 sulfur cluster binding
ISA62_RS06425	COG3302	dmso reductase anchor subunit
ISA62_RS06440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISA62_RS06445	COG1940	carbohydrate kinase activity
ISA62_RS06450	COG0583	DNA-binding transcription factor activity
ISA62_RS06455	COG2814	Major facilitator Superfamily
ISA62_RS06460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISA62_RS06470	COG3591	Belongs to the peptidase S1B family
ISA62_RS06490	COG0628	permease
ISA62_RS06520	COG0679	Auxin Efflux Carrier
ISA62_RS06530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA62_RS06555	COG3290	protein histidine kinase activity
ISA62_RS06560	COG4565	transcriptional regulatory protein
ISA62_RS06595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA62_RS06600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISA62_RS06610	COG0183	Belongs to the thiolase family
ISA62_RS06615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA62_RS06625	COG1414	Transcriptional regulator
ISA62_RS06630	COG2840	Smr protein MutS2
ISA62_RS06635	COG0583	DNA-binding transcription factor activity
ISA62_RS06645	COG1473	amidohydrolase
ISA62_RS06650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISA62_RS06665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA62_RS06680	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISA62_RS06685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISA62_RS06700	COG0531	amino acid
ISA62_RS06710	COG3136	membrane protein required for alginate biosynthesis
ISA62_RS06715	COG0745	RESPONSE REGULATOR receiver
ISA62_RS06725	COG2205	protein histidine kinase activity
ISA62_RS06735	COG0114	fumarate hydratase activity
ISA62_RS06740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA62_RS06740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA62_RS06745	COG1482	cell wall glycoprotein biosynthetic process
ISA62_RS06750	COG5339	Protein conserved in bacteria
ISA62_RS06755	COG1609	Transcriptional regulator
ISA62_RS06760	COG1263	PTS System
ISA62_RS06760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA62_RS06765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISA62_RS06795	COG0425	Belongs to the sulfur carrier protein TusA family
ISA62_RS06800	COG5562	phage envelope protein
ISA62_RS06805	COG0401	homolog of Blt101
ISA62_RS06810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISA62_RS06815	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS06825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA62_RS06830	COG0477	Major facilitator Superfamily
ISA62_RS06835	COG1113	amino acid transport
ISA62_RS06840	COG2988	succinylglutamate desuccinylase activity
ISA62_RS06845	COG3724	N-succinylarginine dihydrolase activity
ISA62_RS06850	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS06855	COG3138	arginine N-succinyltransferase
ISA62_RS06860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA62_RS06870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA62_RS06875	COG0667	Aldo Keto reductase
ISA62_RS06880	COG0583	DNA-binding transcription factor activity
ISA62_RS06905	COG4122	O-methyltransferase activity
ISA62_RS06910	COG1643	Atp-dependent helicase
ISA62_RS06925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA62_RS06930	COG3327	negative regulation of DNA-templated transcription, initiation
ISA62_RS06935	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISA62_RS06940	COG0183	Belongs to the thiolase family
ISA62_RS06945	COG2050	protein possibly involved in aromatic compounds catabolism
ISA62_RS06950	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA62_RS06955	COG1024	Enoyl-CoA hydratase
ISA62_RS06960	COG1024	Enoyl-CoA hydratase
ISA62_RS06965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA62_RS06970	COG2151	metal-sulfur cluster biosynthetic enzyme
ISA62_RS06975	COG3396	Phenylacetate-CoA oxygenase
ISA62_RS06980	COG3460	Phenylacetate-CoA oxygenase
ISA62_RS06985	COG3396	Phenylacetate-CoA oxygenase
ISA62_RS06990	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS06990	COG2030	dehydratase
ISA62_RS07010	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS07015	COG2207	Transcriptional regulator
ISA62_RS07020	COG3784	Protein of unknown function (DUF1318)
ISA62_RS07030	COG2911	Protein conserved in bacteria
ISA62_RS07035	COG0586	Pfam SNARE associated Golgi protein
ISA62_RS07040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA62_RS07045	COG3187	Heat shock protein
ISA62_RS07050	COG3042	response to heat
ISA62_RS07055	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISA62_RS07055	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISA62_RS07055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISA62_RS07055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA62_RS07060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA62_RS07070	COG0589	response to stress
ISA62_RS07080	COG0513	Belongs to the DEAD box helicase family
ISA62_RS07090	COG1349	DNA-binding transcription factor activity
ISA62_RS07095	COG0673	inositol 2-dehydrogenase activity
ISA62_RS07110	COG1113	amino acid transport
ISA62_RS07115	COG1522	sequence-specific DNA binding
ISA62_RS07125	COG1448	Aminotransferase
ISA62_RS07130	COG2011	ABC-type metal ion transport system permease component
ISA62_RS07145	COG0436	Aminotransferase
ISA62_RS07150	COG0604	alcohol dehydrogenase
ISA62_RS07180	COG0583	DNA-binding transcription factor activity
ISA62_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS07205	COG1309	transcriptional regulator
ISA62_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS07295	COG2885	chlorophyll binding
ISA62_RS07320	COG0693	protein deglycase activity
ISA62_RS07325	COG1078	dGTPase activity
ISA62_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS07335	COG0583	DNA-binding transcription factor activity
ISA62_RS07395	COG0784	Response regulator, receiver
ISA62_RS07395	COG2205	protein histidine kinase activity
ISA62_RS07395	COG5002	protein histidine kinase activity
ISA62_RS07400	COG3250	beta-galactosidase activity
ISA62_RS07405	COG0656	L-ascorbic acid biosynthetic process
ISA62_RS07435	COG4166	transmembrane transport
ISA62_RS07445	COG2866	Carboxypeptidase
ISA62_RS07450	COG4948	Mandelate Racemase Muconate Lactonizing
ISA62_RS07455	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISA62_RS07460	COG3180	Ammonia monooxygenase
ISA62_RS07470	COG1486	melibiose metabolic process
ISA62_RS07475	COG0583	DNA-binding transcription factor activity
ISA62_RS07485	COG3106	COG3106 Predicted ATPase
ISA62_RS07495	COG1983	PspC domain protein
ISA62_RS07505	COG1842	Phage shock protein A
ISA62_RS07510	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA62_RS07520	COG1473	amidohydrolase
ISA62_RS07535	COG0702	epimerase
ISA62_RS07550	COG4171	peptide transport system, permease
ISA62_RS07565	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA62_RS07575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISA62_RS07580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA62_RS07580	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA62_RS07595	COG1349	DNA-binding transcription factor activity
ISA62_RS07605	COG0023	Translation Initiation Factor
ISA62_RS07615	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISA62_RS07620	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISA62_RS07625	COG0671	phosphoesterase, PA-phosphatase related
ISA62_RS07635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISA62_RS07660	COG0616	signal peptide processing
ISA62_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS07675	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISA62_RS07700	COG0583	DNA-binding transcription factor activity
ISA62_RS07710	COG0009	L-threonylcarbamoyladenylate synthase
ISA62_RS07720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISA62_RS07725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA62_RS07725	COG0512	Glutamine amidotransferase of anthranilate synthase
ISA62_RS07730	COG0135	phosphoribosylanthranilate isomerase activity
ISA62_RS07730	COG0134	indole-3-glycerol-phosphate synthase activity
ISA62_RS07795	COG3047	cAMP biosynthetic process
ISA62_RS07800	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISA62_RS07830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA62_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS07840	COG1988	membrane-bound metal-dependent
ISA62_RS07845	COG1823	symporter activity
ISA62_RS07855	COG0753	catalase activity
ISA62_RS07865	COG1486	melibiose metabolic process
ISA62_RS07870	COG2169	Transcriptional regulator
ISA62_RS07870	COG1917	Cupin 2, conserved barrel domain protein
ISA62_RS07875	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA62_RS07880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS07890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS07895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA62_RS07905	COG0322	excinuclease ABC activity
ISA62_RS07910	COG3678	ATP-independent chaperone mediated protein folding
ISA62_RS07920	COG3724	N-succinylarginine dihydrolase activity
ISA62_RS07930	COG3138	arginine N-succinyltransferase
ISA62_RS07940	COG0708	Exodeoxyribonuclease III
ISA62_RS07945	COG0398	Pfam SNARE associated Golgi protein
ISA62_RS07950	COG0398	Pfam SNARE associated Golgi protein
ISA62_RS07955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA62_RS07960	COG4134	Bacterial extracellular solute-binding protein
ISA62_RS07965	COG4135	transport system, permease component
ISA62_RS07970	COG4136	ATPase activity
ISA62_RS07975	COG2897	thiosulfate sulfurtransferase activity
ISA62_RS07980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISA62_RS07985	COG0494	nUDIX hydrolase
ISA62_RS07990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA62_RS07995	COG0604	alcohol dehydrogenase
ISA62_RS07995	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS07995	COG3321	synthase
ISA62_RS08000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISA62_RS08005	COG0709	Synthesizes selenophosphate from selenide and ATP
ISA62_RS08015	COG0778	Nitroreductase
ISA62_RS08020	COG0616	signal peptide processing
ISA62_RS08025	COG0252	asparaginase activity
ISA62_RS08030	COG1335	isochorismatase
ISA62_RS08045	COG3139	Protein of unknown function (DUF1315)
ISA62_RS08065	COG0656	L-ascorbic acid biosynthetic process
ISA62_RS08070	COG3713	MltA-interacting MipA family protein
ISA62_RS08220	COG2199	diguanylate cyclase activity
ISA62_RS08220	COG2200	EAL domain
ISA62_RS08270	COG2766	serine protein kinase
ISA62_RS08285	COG0386	Belongs to the glutathione peroxidase family
ISA62_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS08315	COG0583	DNA-binding transcription factor activity
ISA62_RS08320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISA62_RS08325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISA62_RS08340	COG0859	PFAM glycosyl transferase family 9
ISA62_RS08345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA62_RS08355	COG2207	Transcriptional regulator
ISA62_RS08360	COG2807	transmembrane transport
ISA62_RS08365	COG0504	CTP synthase activity
ISA62_RS08370	COG1683	Conserved Protein
ISA62_RS08375	COG3189	MarR family transcriptional regulator
ISA62_RS08380	COG3042	response to heat
ISA62_RS08385	COG2199	diguanylate cyclase activity
ISA62_RS08385	COG2203	Gaf domain
ISA62_RS08405	COG3182	Iron-regulated membrane protein
ISA62_RS08415	COG1560	Kdo2-lipid A biosynthetic process
ISA62_RS08425	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISA62_RS08430	COG3706	GGDEF domain
ISA62_RS08435	COG0583	DNA-binding transcription factor activity
ISA62_RS08440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA62_RS08470	COG1294	oxidase, subunit
ISA62_RS08475	COG1271	oxidase subunit
ISA62_RS08480	COG3546	catalase activity
ISA62_RS08485	COG3685	Protein conserved in bacteria
ISA62_RS08490	COG3685	Protein conserved in bacteria
ISA62_RS08495	COG3729	General stress protein
ISA62_RS08505	COG1063	alcohol dehydrogenase
ISA62_RS08510	COG3813	Protein conserved in bacteria
ISA62_RS08530	COG0640	Transcriptional regulator
ISA62_RS08535	COG0538	isocitrate dehydrogenase activity
ISA62_RS08540	COG1187	pseudouridine synthase activity
ISA62_RS08560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISA62_RS08580	COG2205	protein histidine kinase activity
ISA62_RS08585	COG2850	peptidyl-arginine hydroxylation
ISA62_RS08590	COG1943	Transposase
ISA62_RS08610	COG1177	transmembrane transport
ISA62_RS08625	COG0318	PFAM AMP-dependent synthetase and ligase
ISA62_RS08630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA62_RS08635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA62_RS08640	COG0698	ribose 5-phosphate isomerase
ISA62_RS08655	COG3395	kinase activity
ISA62_RS08670	COG2390	Transcriptional regulator
ISA62_RS08680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISA62_RS08690	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA62_RS08700	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA62_RS08710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISA62_RS08715	COG1376	ErfK ybiS ycfS ynhG family protein
ISA62_RS08715	COG1388	LysM domain
ISA62_RS08730	COG1309	transcriptional regulator
ISA62_RS08745	COG3134	Outer membrane lipoprotein
ISA62_RS08750	COG1252	NADH dehydrogenase
ISA62_RS08775	COG5633	Lipoprotein
ISA62_RS08780	COG0537	adenosine 5'-monophosphoramidase activity
ISA62_RS08790	COG0084	hydrolase, TatD family'
ISA62_RS08795	COG0470	DNA polymerase III
ISA62_RS08805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISA62_RS08810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISA62_RS08815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA62_RS08830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA62_RS08850	COG1399	metal-binding, possibly nucleic acid-binding protein
ISA62_RS08870	COG1530	ribonuclease E activity
ISA62_RS08875	COG0583	DNA-binding transcription factor activity
ISA62_RS08880	COG2814	Major facilitator Superfamily
ISA62_RS08900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA62_RS08945	COG1560	Kdo2-lipid A biosynthetic process
ISA62_RS08960	COG5645	(Lipo)protein
ISA62_RS08995	COG3381	protein complex oligomerization
ISA62_RS09015	COG0583	DNA-binding transcription factor activity
ISA62_RS09025	COG1335	isochorismatase
ISA62_RS09035	COG1702	phosphate starvation-inducible protein PhoH
ISA62_RS09055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA62_RS09065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISA62_RS09080	COG1309	transcriptional regulator
ISA62_RS09115	COG2233	PERMEase
ISA62_RS09125	COG3729	General stress protein
ISA62_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS09170	COG0531	amino acid
ISA62_RS09175	COG0174	glutamine synthetase
ISA62_RS09180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISA62_RS09185	COG1396	sequence-specific DNA binding
ISA62_RS09185	COG1917	Cupin 2, conserved barrel domain protein
ISA62_RS09190	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS09195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA62_RS09200	COG0583	DNA-binding transcription factor activity
ISA62_RS09205	COG0473	3-isopropylmalate dehydrogenase activity
ISA62_RS09210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA62_RS09215	COG4638	Rieske (2fe-2S)
ISA62_RS09220	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS09225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA62_RS09230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS09230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS09230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA62_RS09235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS09240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS09245	COG1882	Formate acetyltransferase
ISA62_RS09250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA62_RS09255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA62_RS09265	COG2207	Transcriptional regulator
ISA62_RS09290	COG2200	EAL domain
ISA62_RS09300	COG0058	SHG alpha-glucan phosphorylase activity
ISA62_RS09315	COG0670	Belongs to the BI1 family
ISA62_RS09330	COG2207	Transcriptional regulator
ISA62_RS09335	COG1881	PFAM PEBP family protein
ISA62_RS09360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS09365	COG2274	protein secretion by the type I secretion system
ISA62_RS09380	COG1832	CoA-binding protein
ISA62_RS09390	COG0210	DNA helicase
ISA62_RS09395	COG3304	Inner membrane component domain
ISA62_RS09400	COG1289	transmembrane transporter activity
ISA62_RS09405	COG3070	regulator of competence-specific genes
ISA62_RS09425	COG1067	ATP-dependent peptidase activity
ISA62_RS09435	COG3130	regulation of translation
ISA62_RS09440	COG3009	Protein conserved in bacteria
ISA62_RS09445	COG3008	intermembrane lipid transfer
ISA62_RS09445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA62_RS09450	COG2995	paraquat-inducible protein a
ISA62_RS09455	COG0488	(ABC) transporter
ISA62_RS09465	COG3217	Mosc domain protein beta barrel domain protein
ISA62_RS09465	COG0633	Ferredoxin
ISA62_RS09480	COG0431	NADPH-dependent FMN reductase
ISA62_RS09485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA62_RS09490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA62_RS09495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA62_RS09505	COG0308	aminopeptidase N
ISA62_RS09515	COG1473	amidohydrolase
ISA62_RS09525	COG0814	amino acid
ISA62_RS09545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA62_RS09550	COG1448	Aminotransferase
ISA62_RS09555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA62_RS09560	COG3108	Peptidase M15
ISA62_RS09575	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ISA62_RS09585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISA62_RS09590	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA62_RS09595	COG3173	Aminoglycoside phosphotransferase
ISA62_RS09610	COG3214	Protein conserved in bacteria
ISA62_RS09625	COG2333	competence protein COMEC
ISA62_RS09625	COG0658	competence protein
ISA62_RS09635	COG0539	negative regulation of cytoplasmic translation
ISA62_RS09655	COG2323	membrane
ISA62_RS09660	COG1944	ATP diphosphatase activity
ISA62_RS09665	COG2116	formate transmembrane transporter activity
ISA62_RS09670	COG1882	Formate acetyltransferase
ISA62_RS09675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA62_RS09680	COG0477	Major facilitator Superfamily
ISA62_RS09685	COG3302	dmso reductase anchor subunit
ISA62_RS09690	COG0437	4 iron, 4 sulfur cluster binding
ISA62_RS09695	COG0243	molybdopterin cofactor binding
ISA62_RS09705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISA62_RS09715	COG1178	ABC-type Fe3 transport system permease component
ISA62_RS09715	COG1674	ftsk spoiiie
ISA62_RS09725	COG0492	ferredoxin-NADP+ reductase activity
ISA62_RS09730	COG4988	ABC transporter
ISA62_RS09735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISA62_RS09750	COG0542	response to heat
ISA62_RS09760	COG1278	Cold shock
ISA62_RS09770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS09775	COG3593	DNA synthesis involved in DNA repair
ISA62_RS09785	COG2431	L-lysine efflux transmembrane transporter activity
ISA62_RS09795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA62_RS09805	COG0028	Belongs to the TPP enzyme family
ISA62_RS09810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISA62_RS09815	COG0702	epimerase
ISA62_RS09820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA62_RS09825	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA62_RS09830	COG5001	Diguanylate cyclase
ISA62_RS09830	COG4251	negative regulation of phosphorylation
ISA62_RS09830	COG3706	GGDEF domain
ISA62_RS09830	COG2203	Gaf domain
ISA62_RS09840	COG1126	abc transporter atp-binding protein
ISA62_RS09845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS09850	COG4215	(ABC) transporter
ISA62_RS09855	COG4160	amino acid transport
ISA62_RS09860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS09865	COG5002	protein histidine kinase activity
ISA62_RS09870	COG0745	RESPONSE REGULATOR receiver
ISA62_RS09885	COG1177	transmembrane transport
ISA62_RS09890	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA62_RS09895	COG3842	ATPase activity
ISA62_RS09900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA62_RS09915	COG0778	Nitroreductase
ISA62_RS09940	COG3226	Transcriptional regulator
ISA62_RS09945	COG0738	Major facilitator superfamily
ISA62_RS09950	COG0561	phosphatase activity
ISA62_RS09955	COG2814	Major facilitator Superfamily
ISA62_RS09960	COG0671	phosphoesterase, PA-phosphatase related
ISA62_RS09965	COG1349	DNA-binding transcription factor activity
ISA62_RS09970	COG1686	Belongs to the peptidase S11 family
ISA62_RS09980	COG0625	glutathione transferase activity
ISA62_RS09995	COG2223	nitrite transmembrane transporter activity
ISA62_RS10015	COG0747	negative chemotaxis
ISA62_RS10030	COG0303	'Molybdopterin
ISA62_RS10035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA62_RS10040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA62_RS10045	COG1882	Formate acetyltransferase
ISA62_RS10050	COG0561	phosphatase activity
ISA62_RS10060	COG1609	Transcriptional regulator
ISA62_RS10065	COG2271	Major facilitator Superfamily
ISA62_RS10075	COG0488	(ABC) transporter
ISA62_RS10080	COG2365	Tyrosine phosphatase family
ISA62_RS10085	COG1376	ErfK ybiS ycfS ynhG family protein
ISA62_RS10090	COG2188	Transcriptional regulator
ISA62_RS10095	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS10100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA62_RS10115	COG2194	sulfuric ester hydrolase activity
ISA62_RS10120	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISA62_RS10135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS10140	COG0765	amino acid transport
ISA62_RS10145	COG1126	abc transporter atp-binding protein
ISA62_RS10150	COG0668	transmembrane transport
ISA62_RS10160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA62_RS10170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISA62_RS10180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA62_RS10185	COG1199	ATP-dependent helicase activity
ISA62_RS10190	COG0513	Belongs to the DEAD box helicase family
ISA62_RS10195	COG3958	Transketolase
ISA62_RS10200	COG3959	Transketolase, thiamine diphosphate binding domain
ISA62_RS10205	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS10210	COG2271	Major facilitator Superfamily
ISA62_RS10220	COG0583	DNA-binding transcription factor activity
ISA62_RS10225	COG1309	transcriptional regulator
ISA62_RS10230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS10235	COG1131	(ABC) transporter
ISA62_RS10240	COG0842	Transport permease protein
ISA62_RS10245	COG0842	Transport permease protein
ISA62_RS10255	COG3568	Endonuclease Exonuclease Phosphatase
ISA62_RS10260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA62_RS10265	COG0392	lysyltransferase activity
ISA62_RS10270	COG0670	Belongs to the BI1 family
ISA62_RS10275	COG0314	molybdopterin synthase activity
ISA62_RS10280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISA62_RS10290	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA62_RS10310	COG0745	RESPONSE REGULATOR receiver
ISA62_RS10315	COG0642	Histidine kinase
ISA62_RS10340	COG2226	methyltransferase
ISA62_RS10355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA62_RS10360	COG1881	PFAM PEBP family protein
ISA62_RS10400	COG4677	pectinesterase activity
ISA62_RS10410	COG0589	response to stress
ISA62_RS10415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS10450	COG0789	Transcriptional regulator
ISA62_RS10455	COG2200	EAL domain
ISA62_RS10480	COG0561	phosphatase activity
ISA62_RS10490	COG4149	molybdate abc transporter
ISA62_RS10495	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISA62_RS10505	COG2005	Transcriptional regulator
ISA62_RS10505	COG3585	molybdate ion transport
ISA62_RS10510	COG1119	ATPase activity
ISA62_RS10520	COG1085	galactose-1-phosphate uridylyltransferase
ISA62_RS10530	COG2017	converts alpha-aldose to the beta-anomer
ISA62_RS10540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA62_RS10555	COG3201	nicotinamide mononucleotide transporter
ISA62_RS10560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISA62_RS10605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISA62_RS10610	COG2885	chlorophyll binding
ISA62_RS10620	COG3064	Membrane
ISA62_RS10625	COG0848	biopolymer transport protein
ISA62_RS10630	COG0811	peptide transport
ISA62_RS10635	COG0824	Thioesterase
ISA62_RS10640	COG3790	cyd operon protein YbgE
ISA62_RS10645	COG4890	Cyd operon protein YbgT
ISA62_RS10650	COG1294	oxidase, subunit
ISA62_RS10655	COG1271	oxidase subunit
ISA62_RS10660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISA62_RS10670	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA62_RS10675	COG0567	Dehydrogenase, E1 component
ISA62_RS10680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA62_RS10685	COG1053	succinate dehydrogenase
ISA62_RS10690	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISA62_RS10695	COG2009	succinate dehydrogenase
ISA62_RS10730	COG1984	allophanate hydrolase subunit 2
ISA62_RS10735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISA62_RS10750	COG0415	Belongs to the DNA photolyase family
ISA62_RS10780	COG2205	protein histidine kinase activity
ISA62_RS10785	COG0745	RESPONSE REGULATOR receiver
ISA62_RS10795	COG0033	Phosphoglucomutase
ISA62_RS10805	COG0596	Alpha beta hydrolase
ISA62_RS10820	COG0735	belongs to the Fur family
ISA62_RS10860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISA62_RS10865	COG1846	Transcriptional regulator
ISA62_RS10865	COG1940	carbohydrate kinase activity
ISA62_RS10870	COG0647	UMP catabolic process
ISA62_RS10875	COG0367	asparagine synthase
ISA62_RS10915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA62_RS10925	COG1702	phosphate starvation-inducible protein PhoH
ISA62_RS10950	COG0765	amino acid transport
ISA62_RS10955	COG0765	amino acid transport
ISA62_RS10960	COG1126	abc transporter atp-binding protein
ISA62_RS10975	COG2888	peptidyl-tyrosine sulfation
ISA62_RS11005	COG0799	negative regulation of ribosome biogenesis
ISA62_RS11015	COG0768	penicillin binding
ISA62_RS11020	COG0772	Belongs to the SEDS family
ISA62_RS11025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA62_RS11030	COG1686	Belongs to the peptidase S11 family
ISA62_RS11045	COG0583	DNA-binding transcription factor activity
ISA62_RS11060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA62_RS11080	COG3069	C4-dicarboxylate transmembrane transporter activity
ISA62_RS11085	COG3719	Belongs to the RNase T2 family
ISA62_RS11090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA62_RS11110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISA62_RS11115	COG0583	DNA-binding transcription factor activity
ISA62_RS11120	COG3969	phosphoadenosine phosphosulfate
ISA62_RS11125	COG1475	DNA binding
ISA62_RS11130	COG0436	Aminotransferase
ISA62_RS11155	COG1129	ABC transporter
ISA62_RS11160	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS11165	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS11175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA62_RS11190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA62_RS11210	COG0483	inositol monophosphate 1-phosphatase activity
ISA62_RS11215	COG2271	Major facilitator Superfamily
ISA62_RS11245	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS11250	COG1129	ABC transporter
ISA62_RS11255	COG0371	Dehydrogenase
ISA62_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS11275	COG2879	small protein
ISA62_RS11280	COG1966	Carbon starvation protein
ISA62_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS11295	COG3433	isochorismatase activity
ISA62_RS11295	COG1535	isochorismatase
ISA62_RS11300	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISA62_RS11305	COG1169	isochorismate synthase
ISA62_RS11310	COG4592	Periplasmic binding protein
ISA62_RS11320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS11325	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS11330	COG1120	ATPase activity
ISA62_RS11335	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ISA62_RS11335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISA62_RS11340	COG3251	PFAM MbtH domain protein
ISA62_RS11345	COG2382	esterase
ISA62_RS11350	COG4771	TonB-dependent receptor
ISA62_RS11355	COG2977	Belongs to the P-Pant transferase superfamily
ISA62_RS11360	COG3958	Transketolase
ISA62_RS11365	COG3959	Transketolase, thiamine diphosphate binding domain
ISA62_RS11370	COG2390	Transcriptional regulator
ISA62_RS11375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISA62_RS11380	COG1879	ABC-type sugar transport system periplasmic component
ISA62_RS11390	COG1129	ABC transporter
ISA62_RS11395	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS11415	COG0583	DNA-binding transcription factor activity
ISA62_RS11420	COG0668	transmembrane transport
ISA62_RS11430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA62_RS11455	COG0747	negative chemotaxis
ISA62_RS11460	COG0601	transmembrane transport
ISA62_RS11465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA62_RS11470	COG0444	Belongs to the ABC transporter superfamily
ISA62_RS11475	COG4608	Belongs to the ABC transporter superfamily
ISA62_RS11485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA62_RS11490	COG4221	oxidoreductase activity
ISA62_RS11500	COG4215	(ABC) transporter
ISA62_RS11505	COG0765	amino acid transport
ISA62_RS11510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ISA62_RS11525	COG0697	spore germination
ISA62_RS11540	COG4608	Belongs to the ABC transporter superfamily
ISA62_RS11545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA62_RS11565	COG3698	Phosphodiester glycosidase
ISA62_RS11605	COG2315	Protein conserved in bacteria
ISA62_RS11610	COG0778	Nitroreductase
ISA62_RS11635	COG0477	Major facilitator Superfamily
ISA62_RS11640	COG0668	transmembrane transport
ISA62_RS11645	COG1609	Transcriptional regulator
ISA62_RS11655	COG0673	inositol 2-dehydrogenase activity
ISA62_RS11665	COG2211	Major facilitator Superfamily
ISA62_RS11670	COG1113	amino acid transport
ISA62_RS11685	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS11690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA62_RS11705	COG0531	amino acid
ISA62_RS11750	COG0667	Aldo Keto reductase
ISA62_RS11755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS11760	COG1473	amidohydrolase
ISA62_RS11790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS11795	COG1120	ATPase activity
ISA62_RS11800	COG1566	PFAM secretion protein HlyD family protein
ISA62_RS11845	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS11850	COG1129	ABC transporter
ISA62_RS11865	COG0673	inositol 2-dehydrogenase activity
ISA62_RS11895	COG3104	oligopeptide transport
ISA62_RS11900	COG1982	Orn Lys Arg decarboxylase major
ISA62_RS11905	COG0531	amino acid
ISA62_RS11910	COG3710	Transcriptional regulator
ISA62_RS11920	COG1560	Kdo2-lipid A biosynthetic process
ISA62_RS11935	COG3188	usher protein
ISA62_RS11940	COG3121	Chaperone
ISA62_RS11945	COG3539	Fimbrial protein
ISA62_RS12115	COG3772	lysozyme
ISA62_RS12315	COG2501	S4 domain
ISA62_RS12325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISA62_RS12340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISA62_RS12345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISA62_RS12365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISA62_RS12370	COG4181	ATPase activity
ISA62_RS12375	COG2755	lipolytic protein G-D-S-L family
ISA62_RS12380	COG0300	oxidoreductase activity
ISA62_RS12385	COG3118	belongs to the thioredoxin family
ISA62_RS12390	COG0390	transport system, permease component
ISA62_RS12395	COG4619	ABC transporter
ISA62_RS12400	COG0330	HflC and HflK could
ISA62_RS12405	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISA62_RS12420	COG3735	TraB family
ISA62_RS12425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA62_RS12435	COG2223	nitrite transmembrane transporter activity
ISA62_RS12440	COG4651	solute:proton antiporter activity
ISA62_RS12440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISA62_RS12445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS12485	COG2832	Protein of unknown function (DUF454)
ISA62_RS12490	COG3923	Primosomal replication protein n
ISA62_RS12505	COG3264	Mechanosensitive ion channel
ISA62_RS12505	COG1196	nuclear chromosome segregation
ISA62_RS12510	COG1309	transcriptional regulator
ISA62_RS12515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS12520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA62_RS12535	COG0110	maltose O-acetyltransferase activity
ISA62_RS12585	COG1874	Beta-galactosidase
ISA62_RS12590	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISA62_RS12595	COG3833	ABC-type maltose transport systems, permease component
ISA62_RS12600	COG1175	transmembrane transport
ISA62_RS12605	COG2182	Extracellular solute-binding protein
ISA62_RS12615	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA62_RS12630	COG2364	Membrane
ISA62_RS12660	COG3695	enzyme binding
ISA62_RS12665	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISA62_RS12670	COG1946	Acyl-CoA thioesterase
ISA62_RS12675	COG0004	ammonium transporteR
ISA62_RS12680	COG0347	Belongs to the P(II) protein family
ISA62_RS12685	COG1132	(ABC) transporter
ISA62_RS12690	COG1132	(ABC) transporter
ISA62_RS12695	COG1522	sequence-specific DNA binding
ISA62_RS12710	COG4533	DNA binding
ISA62_RS12720	COG0824	Thioesterase
ISA62_RS12725	COG1555	photosystem II stabilization
ISA62_RS12730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA62_RS12735	COG0776	regulation of translation
ISA62_RS12740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISA62_RS12760	COG0271	Belongs to the BolA IbaG family
ISA62_RS12765	COG3056	Lipoprotein
ISA62_RS12770	COG2223	nitrite transmembrane transporter activity
ISA62_RS12775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISA62_RS12780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISA62_RS12785	COG1845	cytochrome c oxidase, subunit III
ISA62_RS12790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISA62_RS12805	COG1414	Transcriptional regulator
ISA62_RS12810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA62_RS12815	COG1053	succinate dehydrogenase
ISA62_RS12825	COG1053	succinate dehydrogenase
ISA62_RS12840	COG0673	inositol 2-dehydrogenase activity
ISA62_RS12845	COG2814	Major facilitator Superfamily
ISA62_RS12855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISA62_RS12880	COG0142	geranyltranstransferase activity
ISA62_RS12890	COG0667	Aldo Keto reductase
ISA62_RS12895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISA62_RS12915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA62_RS12915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA62_RS12925	COG4238	major outer membrane lipoprotein
ISA62_RS12945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA62_RS12950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA62_RS12955	COG1862	Preprotein translocase
ISA62_RS12980	COG0450	alkyl hydroperoxide reductase
ISA62_RS12990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS13005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS13015	COG1228	amidohydrolase
ISA62_RS13025	COG1335	isochorismatase
ISA62_RS13030	COG0583	DNA-binding transcription factor activity
ISA62_RS13035	COG0366	Alpha amylase catalytic
ISA62_RS13060	COG0420	3'-5' exonuclease activity
ISA62_RS13065	COG0419	ATPase involved in DNA repair
ISA62_RS13070	COG1940	carbohydrate kinase activity
ISA62_RS13085	COG4126	flavin adenine dinucleotide binding
ISA62_RS13095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA62_RS13100	COG3416	Protein conserved in bacteria
ISA62_RS13110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISA62_RS13120	COG1785	Belongs to the alkaline phosphatase family
ISA62_RS13160	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ISA62_RS13165	COG1335	isochorismatase
ISA62_RS13170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISA62_RS13175	COG0113	porphobilinogen synthase activity
ISA62_RS13180	COG1943	Transposase
ISA62_RS13190	COG2175	clavaminate synthase activity
ISA62_RS13195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA62_RS13200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ISA62_RS13205	COG4521	taurine ABC transporter
ISA62_RS13210	COG2040	homocysteine
ISA62_RS13215	COG0833	amino acid
ISA62_RS13225	COG0531	amino acid
ISA62_RS13230	COG4303	Ethanolamine ammonia lyase large subunit
ISA62_RS13235	COG4302	ethanolamine ammonia-lyase activity
ISA62_RS13275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS13280	COG1126	abc transporter atp-binding protein
ISA62_RS13285	COG4597	amino acid ABC transporter
ISA62_RS13290	COG0765	amino acid transport
ISA62_RS13305	COG3188	usher protein
ISA62_RS13330	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISA62_RS13340	COG3639	organic phosphonate transmembrane transporter activity
ISA62_RS13360	COG0791	NLP P60 protein
ISA62_RS13415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISA62_RS13420	COG0022	dehydrogenase e1 component
ISA62_RS13425	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA62_RS13430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA62_RS13450	COG1070	Carbohydrate kinase
ISA62_RS13455	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS13460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA62_RS13465	COG3775	system Galactitol-specific IIC component
ISA62_RS13470	COG0625	glutathione transferase activity
ISA62_RS13475	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISA62_RS13490	COG0579	oxidoreductase
ISA62_RS13495	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS13500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA62_RS13505	COG1113	amino acid transport
ISA62_RS13510	COG1802	Transcriptional regulator
ISA62_RS13530	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISA62_RS13535	COG0454	-acetyltransferase
ISA62_RS13550	COG2991	Protein conserved in bacteria
ISA62_RS13565	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA62_RS13570	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA62_RS13585	COG3034	peptidoglycan biosynthetic process
ISA62_RS13590	COG0121	glutamine amidotransferase
ISA62_RS13600	COG1960	acyl-CoA dehydrogenase activity
ISA62_RS13605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA62_RS13615	COG0583	DNA-binding transcription factor activity
ISA62_RS13625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA62_RS13635	COG2226	methyltransferase
ISA62_RS13645	COG1388	LysM domain
ISA62_RS13645	COG0741	lytic transglycosylase activity
ISA62_RS13650	COG2226	methyltransferase
ISA62_RS13660	COG2814	Major facilitator Superfamily
ISA62_RS13665	COG0583	DNA-binding transcription factor activity
ISA62_RS13670	COG0656	L-ascorbic acid biosynthetic process
ISA62_RS13705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISA62_RS13715	COG2011	ABC-type metal ion transport system permease component
ISA62_RS13720	COG1464	Belongs to the NlpA lipoprotein family
ISA62_RS13730	COG1720	tRNA m6t6A37 methyltransferase activity
ISA62_RS13740	COG0791	NLP P60 protein
ISA62_RS13745	COG3015	lipoprotein NlpE involved in copper resistance
ISA62_RS13750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ISA62_RS13765	COG4568	rho-dependent transcription termination
ISA62_RS13775	COG0346	lactoylglutathione lyase activity
ISA62_RS13780	COG1982	Orn Lys Arg decarboxylase major
ISA62_RS13790	COG0587	DNA-directed DNA polymerase activity
ISA62_RS13820	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ISA62_RS13830	COG0750	zinc metalloprotease
ISA62_RS13835	COG0575	Belongs to the CDS family
ISA62_RS13845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISA62_RS13870	COG0024	Methionine aminopeptidase
ISA62_RS13875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ISA62_RS13890	COG3835	regulator
ISA62_RS13895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA62_RS13915	COG2860	membrane
ISA62_RS13935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS13940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA62_RS13945	COG1120	ATPase activity
ISA62_RS13955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA62_RS14050	COG1643	Atp-dependent helicase
ISA62_RS14055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISA62_RS14075	COG0617	tRNA 3'-terminal CCA addition
ISA62_RS14080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISA62_RS14100	COG0726	polysaccharide deacetylase
ISA62_RS14105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS14110	COG0842	Transport permease protein
ISA62_RS14115	COG1131	(ABC) transporter
ISA62_RS14120	COG0288	reversible hydration of carbon dioxide
ISA62_RS14135	COG4993	Dehydrogenase
ISA62_RS14140	COG2132	Multicopper oxidase
ISA62_RS14185	COG3064	Membrane
ISA62_RS14200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA62_RS14205	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA62_RS14210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISA62_RS14215	COG2186	Transcriptional regulator
ISA62_RS14220	COG1113	amino acid transport
ISA62_RS14225	COG2211	Major facilitator Superfamily
ISA62_RS14230	COG3940	Belongs to the glycosyl hydrolase 43 family
ISA62_RS14235	COG3725	Membrane protein required for beta-lactamase induction
ISA62_RS14240	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA62_RS14250	COG4969	Belongs to the N-Me-Phe pilin family
ISA62_RS14255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISA62_RS14260	COG1459	type II secretion system
ISA62_RS14285	COG0494	nUDIX hydrolase
ISA62_RS14305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISA62_RS14310	COG0849	cell division
ISA62_RS14335	COG0772	Belongs to the SEDS family
ISA62_RS14350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISA62_RS14355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISA62_RS14360	COG0768	penicillin binding
ISA62_RS14380	COG1609	Transcriptional regulator
ISA62_RS14390	COG0028	Belongs to the TPP enzyme family
ISA62_RS14435	COG0738	Major facilitator superfamily
ISA62_RS14445	COG0583	DNA-binding transcription factor activity
ISA62_RS14450	COG2271	Major facilitator Superfamily
ISA62_RS14455	COG2814	Major facilitator Superfamily
ISA62_RS14475	COG1178	ABC-type Fe3 transport system permease component
ISA62_RS14485	COG0586	Pfam SNARE associated Golgi protein
ISA62_RS14505	COG0235	Class ii aldolase
ISA62_RS14510	COG0417	DNA replication proofreading
ISA62_RS14520	COG0564	pseudouridine synthase activity
ISA62_RS14530	COG3493	citrate carrier protein
ISA62_RS14545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISA62_RS14550	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISA62_RS14560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA62_RS14605	COG0505	Belongs to the CarA family
ISA62_RS14640	COG1047	Peptidyl-prolyl cis-trans
ISA62_RS14655	COG0196	riboflavin kinase activity
ISA62_RS14665	COG0583	DNA-binding transcription factor activity
ISA62_RS14690	COG4735	regulation of single-species biofilm formation
ISA62_RS14695	COG1584	GPR1 FUN34 yaaH family protein
ISA62_RS14700	COG0477	Major facilitator Superfamily
ISA62_RS14705	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA62_RS14710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA62_RS14715	COG1115	amino acid carrier protein
ISA62_RS14730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISA62_RS14740	COG0527	aspartate kinase activity
ISA62_RS14740	COG0460	homoserine dehydrogenase
ISA62_RS14750	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ISA62_RS14760	COG0745	RESPONSE REGULATOR receiver
ISA62_RS14765	COG4452	Inner membrane protein CreD
ISA62_RS14770	COG2205	protein histidine kinase activity
ISA62_RS14775	COG0745	RESPONSE REGULATOR receiver
ISA62_RS14780	COG3045	CreA protein
ISA62_RS14785	COG3708	Transcriptional regulator
ISA62_RS14785	COG2207	Transcriptional regulator
ISA62_RS14805	COG0741	lytic transglycosylase activity
ISA62_RS14810	COG0488	(ABC) transporter
ISA62_RS14820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISA62_RS14825	COG0560	Phosphoserine phosphatase
ISA62_RS14830	COG3726	membrane protein affecting hemolysin expression
ISA62_RS14860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA62_RS14865	COG0084	hydrolase, TatD family'
ISA62_RS14870	COG4667	esterase of the alpha-beta hydrolase superfamily
ISA62_RS14880	COG2823	Periplasmic or secreted lipoprotein
ISA62_RS14890	COG1011	Hydrolase
ISA62_RS14895	COG0456	acetyltransferase
ISA62_RS14900	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISA62_RS14935	COG3706	GGDEF domain
ISA62_RS14940	COG4114	ferric iron reductase
ISA62_RS14945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS14950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA62_RS14955	COG2197	response regulator
ISA62_RS14975	COG2966	Psort location CytoplasmicMembrane, score
ISA62_RS14990	COG1484	DNA-dependent DNA replication
ISA62_RS15005	COG5464	transposase or invertase
ISA62_RS15015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA62_RS15020	COG3716	PTS system mannose fructose sorbose family IID component
ISA62_RS15025	COG3715	PTS system
ISA62_RS15040	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISA62_RS15040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA62_RS15050	COG1063	alcohol dehydrogenase
ISA62_RS15055	COG1802	Transcriptional regulator
ISA62_RS15060	COG2271	Major facilitator Superfamily
ISA62_RS15065	COG1214	PFAM Peptidase M22, glycoprotease
ISA62_RS15065	COG0456	acetyltransferase
ISA62_RS15075	COG1737	Transcriptional regulator
ISA62_RS15080	COG0800	Aldolase
ISA62_RS15085	COG3734	2-keto-3-deoxy-galactonokinase
ISA62_RS15100	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ISA62_RS15130	COG1846	Transcriptional regulator
ISA62_RS15140	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA62_RS15150	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS15155	COG3384	dioxygenase
ISA62_RS15165	COG3971	2-oxopent-4-enoate hydratase activity
ISA62_RS15185	COG2368	4-hydroxyphenylacetate
ISA62_RS15190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA62_RS15205	COG1966	Carbon starvation protein
ISA62_RS15210	COG2879	small protein
ISA62_RS15215	COG0523	cobalamin synthesis protein
ISA62_RS15225	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS15230	COG5464	transposase or invertase
ISA62_RS15235	COG2207	Transcriptional regulator
ISA62_RS15235	COG1917	Cupin 2, conserved barrel domain protein
ISA62_RS15245	COG2733	membrane
ISA62_RS15260	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ISA62_RS15265	COG1924	4 iron, 4 sulfur cluster binding
ISA62_RS15280	COG1566	PFAM secretion protein HlyD family protein
ISA62_RS15290	COG5457	Domain of unknown function (DUF1127)
ISA62_RS15295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA62_RS15305	COG0583	DNA-binding transcription factor activity
ISA62_RS15310	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA62_RS15320	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS15325	COG1129	ABC transporter
ISA62_RS15330	COG1879	ABC-type sugar transport system periplasmic component
ISA62_RS15340	COG3706	GGDEF domain
ISA62_RS15345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS15350	COG1129	ABC transporter
ISA62_RS15350	COG0842	Transport permease protein
ISA62_RS15355	COG0842	Transport permease protein
ISA62_RS15385	COG2850	peptidyl-arginine hydroxylation
ISA62_RS15400	COG5002	protein histidine kinase activity
ISA62_RS15405	COG0745	RESPONSE REGULATOR receiver
ISA62_RS15410	COG1538	Outer membrane efflux protein
ISA62_RS15415	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS15425	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA62_RS15435	COG3040	lipid binding
ISA62_RS15440	COG0789	Transcriptional regulator
ISA62_RS15450	COG0300	oxidoreductase activity
ISA62_RS15465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA62_RS15485	COG3272	Protein of unknown function (DUF1722)
ISA62_RS15490	COG4580	involved in the transport of maltose and maltodextrins
ISA62_RS15495	COG2115	Belongs to the xylose isomerase family
ISA62_RS15500	COG2211	Major facilitator Superfamily
ISA62_RS15505	COG3507	Belongs to the glycosyl hydrolase 43 family
ISA62_RS15525	COG1216	Glycosyl transferase, family 2
ISA62_RS15565	COG1715	Restriction endonuclease
ISA62_RS15570	COG1196	nuclear chromosome segregation
ISA62_RS15590	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ISA62_RS15595	COG0582	viral genome integration into host DNA
ISA62_RS15605	COG0288	reversible hydration of carbon dioxide
ISA62_RS15610	COG0659	secondary active sulfate transmembrane transporter activity
ISA62_RS15615	COG1064	alcohol dehydrogenase
ISA62_RS15620	COG1175	transmembrane transport
ISA62_RS15625	COG0395	ABC-type sugar transport system, permease component
ISA62_RS15630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA62_RS15635	COG3842	ATPase activity
ISA62_RS15650	COG1082	Xylose isomerase domain protein TIM barrel
ISA62_RS15660	COG3962	Belongs to the TPP enzyme family
ISA62_RS15665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS15670	COG1737	Transcriptional regulator
ISA62_RS15670	COG0837	glucose binding
ISA62_RS15675	COG3718	enzyme involved in inositol metabolism
ISA62_RS15690	COG0433	COG0433 Predicted ATPase
ISA62_RS15695	COG0795	lipopolysaccharide-transporting ATPase activity
ISA62_RS15700	COG0795	lipopolysaccharide-transporting ATPase activity
ISA62_RS15710	COG2927	DNA polymerase III (CHI subunit)
ISA62_RS15715	COG0525	valine-tRNA ligase activity
ISA62_RS15740	COG2188	Transcriptional regulator
ISA62_RS15745	COG1288	antiporter activity
ISA62_RS15750	COG1228	amidohydrolase
ISA62_RS15755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS15760	COG2222	sugar isomerase
ISA62_RS15765	COG2731	YhcH YjgK YiaL family protein
ISA62_RS15800	COG1263	PTS System
ISA62_RS15800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA62_RS15805	COG0366	Alpha amylase catalytic
ISA62_RS15810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS15815	COG1486	melibiose metabolic process
ISA62_RS15840	COG0602	queuosine metabolic process
ISA62_RS15845	COG2026	Addiction module toxin, RelE StbE family
ISA62_RS15850	COG3077	Addiction module antitoxin, RelB DinJ family
ISA62_RS15855	COG3711	transcriptional antiterminator
ISA62_RS15855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS15860	COG2706	6-phosphogluconolactonase activity
ISA62_RS15875	COG3964	amidohydrolase
ISA62_RS15915	COG0312	modulator of DNA gyrase
ISA62_RS15940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISA62_RS15950	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS15955	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS15960	COG1129	ABC transporter
ISA62_RS15965	COG1879	ABC-type sugar transport system periplasmic component
ISA62_RS15985	COG2105	PFAM AIG2 family protein
ISA62_RS15990	COG2911	Protein conserved in bacteria
ISA62_RS15995	COG0729	surface antigen
ISA62_RS16005	COG1253	flavin adenine dinucleotide binding
ISA62_RS16030	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISA62_RS16045	COG1733	regulation of RNA biosynthetic process
ISA62_RS16050	COG0702	epimerase
ISA62_RS16060	COG0697	spore germination
ISA62_RS16070	COG1113	amino acid transport
ISA62_RS16075	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA62_RS16080	COG3061	Opacity-associated protein A
ISA62_RS16090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISA62_RS16095	COG2965	DNA replication, synthesis of RNA primer
ISA62_RS16155	COG1073	alpha beta
ISA62_RS16160	COG3650	response to hydrogen peroxide
ISA62_RS16170	COG1960	acyl-CoA dehydrogenase activity
ISA62_RS16175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA62_RS16180	COG0557	exoribonuclease II activity
ISA62_RS16195	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISA62_RS16205	COG0330	HflC and HflK could
ISA62_RS16210	COG0330	HflC and HflK could
ISA62_RS16215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISA62_RS16235	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA62_RS16240	COG0802	atpase or kinase
ISA62_RS16245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISA62_RS16245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISA62_RS16250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISA62_RS16270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS16290	COG1511	domain protein
ISA62_RS16290	COG3264	Mechanosensitive ion channel
ISA62_RS16305	COG1053	succinate dehydrogenase
ISA62_RS16310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA62_RS16330	COG2076	Multidrug Resistance protein
ISA62_RS16335	COG5510	response to toxic substance
ISA62_RS16350	COG1509	lysine 2,3-aminomutase activity
ISA62_RS16415	COG0531	amino acid
ISA62_RS16420	COG3030	protein affecting phage T7 exclusion by the F plasmid
ISA62_RS16425	COG1027	Aspartate ammonia-lyase
ISA62_RS16430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA62_RS16445	COG1309	transcriptional regulator
ISA62_RS16485	COG1649	PFAM Uncharacterised BCR, COG1649
ISA62_RS16485	COG0726	polysaccharide deacetylase
ISA62_RS16490	COG1215	transferase activity, transferring glycosyl groups
ISA62_RS16505	COG0861	Integral membrane protein TerC family
ISA62_RS16545	COG1486	melibiose metabolic process
ISA62_RS16550	COG2169	Transcriptional regulator
ISA62_RS16560	COG2824	Alkylphosphonate utilization operon protein PhnA
ISA62_RS16565	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ISA62_RS16570	COG2188	Transcriptional regulator
ISA62_RS16575	COG3624	Phosphonate C-P lyase system protein PhnG
ISA62_RS16580	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISA62_RS16585	COG3626	phosphonate metabolism
ISA62_RS16590	COG3627	carbon phosphorus lyase activity
ISA62_RS16595	COG4107	phosphonate C-P lyase system protein PhnK
ISA62_RS16600	COG4778	phosphonate C-P lyase system protein PhnL
ISA62_RS16605	COG3454	Phosphonate metabolism
ISA62_RS16615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISA62_RS16625	COG0784	Response regulator, receiver
ISA62_RS16625	COG4191	Histidine kinase
ISA62_RS16630	COG1129	ABC transporter
ISA62_RS16635	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS16675	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ISA62_RS16680	COG1301	dicarboxylic acid transport
ISA62_RS16690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISA62_RS16695	COG3162	membrane
ISA62_RS16725	COG3539	Fimbrial protein
ISA62_RS16730	COG1346	cytolysis
ISA62_RS16735	COG1380	Effector of murein hydrolase LrgA
ISA62_RS16740	COG0583	DNA-binding transcription factor activity
ISA62_RS16745	COG0025	NhaP-type Na H and K H
ISA62_RS16750	COG2252	PERMEase
ISA62_RS16755	COG0625	glutathione transferase activity
ISA62_RS16760	COG0789	Transcriptional regulator
ISA62_RS16770	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA62_RS16800	COG1234	tRNA 3'-trailer cleavage
ISA62_RS16805	COG1609	Transcriptional regulator
ISA62_RS16810	COG0483	inositol monophosphate 1-phosphatase activity
ISA62_RS16820	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA62_RS16840	COG4771	TonB-dependent receptor
ISA62_RS16845	COG0741	lytic transglycosylase activity
ISA62_RS16860	COG2315	Protein conserved in bacteria
ISA62_RS16865	COG0432	Pfam Uncharacterised protein family UPF0047
ISA62_RS16880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISA62_RS16885	COG0305	Participates in initiation and elongation during chromosome replication
ISA62_RS16900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA62_RS16910	COG0735	belongs to the Fur family
ISA62_RS16915	COG3237	CsbD-like
ISA62_RS16925	COG0534	Mate efflux family protein
ISA62_RS16935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISA62_RS17005	COG0251	oxidation-reduction process
ISA62_RS17015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISA62_RS17025	COG0527	aspartate kinase activity
ISA62_RS17075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISA62_RS17085	COG0456	acetyltransferase
ISA62_RS17115	COG0151	Belongs to the GarS family
ISA62_RS17125	COG4191	Histidine kinase
ISA62_RS17130	COG3678	ATP-independent chaperone mediated protein folding
ISA62_RS17165	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ISA62_RS17180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA62_RS17185	COG2104	thiamine diphosphate biosynthetic process
ISA62_RS17200	COG3706	GGDEF domain
ISA62_RS17210	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA62_RS17215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA62_RS17250	COG0250	Participates in transcription elongation, termination and antitermination
ISA62_RS17325	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISA62_RS17335	COG1739	Uncharacterized protein family UPF0029
ISA62_RS17375	COG0805	protein transport
ISA62_RS17395	COG3165	ubiquinone biosynthetic process from chorismate
ISA62_RS17425	COG0583	DNA-binding transcription factor activity
ISA62_RS17430	COG0697	spore germination
ISA62_RS17435	COG0561	phosphatase activity
ISA62_RS17440	COG2267	carboxylic ester hydrolase activity
ISA62_RS17445	COG1280	lysine exporter protein (LysE YggA)
ISA62_RS17455	COG1280	lysine exporter protein (LysE YggA)
ISA62_RS17485	COG0210	DNA helicase
ISA62_RS17490	COG1011	Hydrolase
ISA62_RS17520	COG3072	Adenylate cyclase
ISA62_RS17535	COG2959	enzyme of heme biosynthesis
ISA62_RS17540	COG3071	HemY protein
ISA62_RS17585	COG2244	polysaccharide biosynthetic process
ISA62_RS17590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISA62_RS17595	COG0456	acetyltransferase
ISA62_RS17600	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISA62_RS17605	COG1088	dTDP-glucose 4,6-dehydratase activity
ISA62_RS17610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISA62_RS17615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISA62_RS17625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISA62_RS17630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISA62_RS17635	COG3118	belongs to the thioredoxin family
ISA62_RS17660	COG1811	Na channel or pump
ISA62_RS17670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA62_RS17675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA62_RS17685	COG0583	DNA-binding transcription factor activity
ISA62_RS17690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA62_RS17705	COG3978	acetolactate synthase activity
ISA62_RS17725	COG3085	chromosome segregation
ISA62_RS17800	COG0583	DNA-binding transcription factor activity
ISA62_RS17815	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISA62_RS17830	COG3443	Belongs to the bacterial solute-binding protein 9 family
ISA62_RS17835	COG2207	Transcriptional regulator
ISA62_RS17845	COG0371	Dehydrogenase
ISA62_RS17850	COG0697	spore germination
ISA62_RS17860	COG0583	DNA-binding transcription factor activity
ISA62_RS17870	COG0737	Belongs to the 5'-nucleotidase family
ISA62_RS17880	COG0527	aspartate kinase activity
ISA62_RS17880	COG0460	homoserine dehydrogenase
ISA62_RS17885	COG0626	cystathionine gamma-synthase activity
ISA62_RS17900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISA62_RS17905	COG1609	Transcriptional regulator
ISA62_RS17910	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA62_RS17945	COG3678	ATP-independent chaperone mediated protein folding
ISA62_RS17950	COG0745	RESPONSE REGULATOR receiver
ISA62_RS17955	COG2205	protein histidine kinase activity
ISA62_RS17960	COG2258	MOSC domain
ISA62_RS17965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISA62_RS18005	COG1129	ABC transporter
ISA62_RS18010	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS18015	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS18020	COG1454	alcohol dehydrogenase
ISA62_RS18035	COG2211	Major facilitator Superfamily
ISA62_RS18040	COG1609	Transcriptional regulator
ISA62_RS18045	COG2211	Major facilitator Superfamily
ISA62_RS18105	COG0205	6-phosphofructokinase activity
ISA62_RS18125	COG0437	4 iron, 4 sulfur cluster binding
ISA62_RS18130	COG2864	formate dehydrogenase
ISA62_RS18145	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISA62_RS18155	COG0456	acetyltransferase
ISA62_RS18170	COG1011	Hydrolase
ISA62_RS18185	COG3852	Histidine kinase
ISA62_RS18200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA62_RS18220	COG0204	Acyl-transferase
ISA62_RS18230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISA62_RS18235	COG3084	Protein conserved in bacteria
ISA62_RS18245	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISA62_RS18270	COG2186	Transcriptional regulator
ISA62_RS18275	COG0477	Major facilitator Superfamily
ISA62_RS18280	COG1609	Transcriptional regulator
ISA62_RS18285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS18295	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS18300	COG1129	ABC transporter
ISA62_RS18330	COG1522	sequence-specific DNA binding
ISA62_RS18335	COG0716	FMN binding
ISA62_RS18350	COG3312	ion transport
ISA62_RS18400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA62_RS18405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISA62_RS18410	COG0573	inorganic phosphate transmembrane transporter activity
ISA62_RS18415	COG0581	inorganic phosphate transmembrane transporter activity
ISA62_RS18420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISA62_RS18425	COG0704	Plays a role in the regulation of phosphate uptake
ISA62_RS18435	COG2382	esterase
ISA62_RS18440	COG0363	glucosamine-6-phosphate deaminase activity
ISA62_RS18445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA62_RS18450	COG2252	PERMEase
ISA62_RS18455	COG0431	NADPH-dependent FMN reductase
ISA62_RS18460	COG2091	lysine biosynthetic process via aminoadipic acid
ISA62_RS18490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISA62_RS18525	COG0561	phosphatase activity
ISA62_RS18545	COG2186	Transcriptional regulator
ISA62_RS18550	COG3734	2-keto-3-deoxy-galactonokinase
ISA62_RS18555	COG0800	Aldolase
ISA62_RS18565	COG2271	Major facilitator Superfamily
ISA62_RS18570	COG0823	Involved in the tonB-independent uptake of proteins
ISA62_RS18575	COG5645	(Lipo)protein
ISA62_RS18590	COG3645	SOS response
ISA62_RS18600	COG2188	Transcriptional regulator
ISA62_RS18615	COG2149	membrane
ISA62_RS18635	COG2610	gluconate transmembrane transporter activity
ISA62_RS18645	COG0583	DNA-binding transcription factor activity
ISA62_RS18650	COG2814	Major facilitator Superfamily
ISA62_RS18680	COG0028	Belongs to the TPP enzyme family
ISA62_RS18685	COG0440	acetolactate synthase activity
ISA62_RS18690	COG2197	response regulator
ISA62_RS18700	COG2271	Major facilitator Superfamily
ISA62_RS18740	COG2188	Transcriptional regulator
ISA62_RS18765	COG4580	involved in the transport of maltose and maltodextrins
ISA62_RS18770	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA62_RS18775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS18775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS18785	COG1609	Transcriptional regulator
ISA62_RS18795	COG3384	dioxygenase
ISA62_RS18800	COG0583	DNA-binding transcription factor activity
ISA62_RS18805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISA62_RS18810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISA62_RS18815	COG2828	Protein conserved in bacteria
ISA62_RS18830	COG0697	spore germination
ISA62_RS18835	COG1263	PTS System
ISA62_RS18835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA62_RS18845	COG2814	Major facilitator Superfamily
ISA62_RS18855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA62_RS18890	COG0583	DNA-binding transcription factor activity
ISA62_RS18915	COG1464	Belongs to the NlpA lipoprotein family
ISA62_RS18930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISA62_RS18940	COG1064	alcohol dehydrogenase
ISA62_RS18970	COG2211	Major facilitator Superfamily
ISA62_RS18975	COG1501	Belongs to the glycosyl hydrolase 31 family
ISA62_RS18985	COG1486	melibiose metabolic process
ISA62_RS18990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA62_RS18990	COG1263	PTS System
ISA62_RS18995	COG2982	Protein involved in outer membrane biogenesis
ISA62_RS19000	COG2233	PERMEase
ISA62_RS19005	COG0786	glutamate:sodium symporter activity
ISA62_RS19025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISA62_RS19050	COG3152	Membrane
ISA62_RS19060	COG1494	fructose-1,6-bisphosphatase
ISA62_RS19065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISA62_RS19070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA62_RS19075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA62_RS19095	COG2860	membrane
ISA62_RS19105	COG2169	Transcriptional regulator
ISA62_RS19105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA62_RS19110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ISA62_RS19115	COG1561	YicC-like family, N-terminal region
ISA62_RS19135	COG1131	(ABC) transporter
ISA62_RS19140	COG0842	Transport permease protein
ISA62_RS19170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISA62_RS19205	COG1519	Transferase
ISA62_RS19210	COG1216	Glycosyl transferase, family 2
ISA62_RS19215	COG0438	transferase activity, transferring glycosyl groups
ISA62_RS19225	COG0859	PFAM glycosyl transferase family 9
ISA62_RS19250	COG0859	PFAM glycosyl transferase family 9
ISA62_RS19265	COG0156	8-amino-7-oxononanoate synthase activity
ISA62_RS19275	COG0463	Glycosyl transferase, family 2
ISA62_RS19280	COG2861	carbohydrate metabolic process
ISA62_RS19285	COG4942	peptidase
ISA62_RS19295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA62_RS19300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA62_RS19320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISA62_RS19330	COG2186	Transcriptional regulator
ISA62_RS19350	COG3722	fumarate hydratase activity
ISA62_RS19370	COG0625	glutathione transferase activity
ISA62_RS19380	COG3276	selenocysteine insertion sequence binding
ISA62_RS19385	COG1414	Transcriptional regulator
ISA62_RS19390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA62_RS19395	COG3977	Valine--pyruvate aminotransferase
ISA62_RS19400	COG0366	Alpha amylase catalytic
ISA62_RS19405	COG2992	FlgJ-related protein
ISA62_RS19410	COG1609	Transcriptional regulator
ISA62_RS19410	COG2207	Transcriptional regulator
ISA62_RS19415	COG4214	carbohydrate transport
ISA62_RS19425	COG4213	ABC transporter substrate-binding protein
ISA62_RS19440	COG4682	membrane
ISA62_RS19445	COG4682	membrane
ISA62_RS19450	COG3274	enterobacterial common antigen metabolic process
ISA62_RS19480	COG1278	Cold shock
ISA62_RS19485	COG2944	sequence-specific DNA binding
ISA62_RS19490	COG2814	Major facilitator Superfamily
ISA62_RS19510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA62_RS19520	COG1609	Transcriptional regulator
ISA62_RS19525	COG2885	chlorophyll binding
ISA62_RS19530	COG0243	molybdopterin cofactor binding
ISA62_RS19535	COG0456	acetyltransferase
ISA62_RS19540	COG2818	Glycosylase
ISA62_RS19545	COG5571	outer membrane autotransporter
ISA62_RS19550	COG2223	nitrite transmembrane transporter activity
ISA62_RS19575	COG0747	negative chemotaxis
ISA62_RS19580	COG0601	transmembrane transport
ISA62_RS19585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA62_RS19590	COG0444	Belongs to the ABC transporter superfamily
ISA62_RS19595	COG4608	Belongs to the ABC transporter superfamily
ISA62_RS19610	COG2894	cell division
ISA62_RS19620	COG1215	transferase activity, transferring glycosyl groups
ISA62_RS19625	COG0457	Tetratricopeptide repeat
ISA62_RS19640	COG2194	sulfuric ester hydrolase activity
ISA62_RS19670	COG1215	transferase activity, transferring glycosyl groups
ISA62_RS19675	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISA62_RS19680	COG0457	Tetratricopeptide repeat
ISA62_RS19680	COG3118	belongs to the thioredoxin family
ISA62_RS19685	COG2200	EAL domain
ISA62_RS19685	COG2199	diguanylate cyclase activity
ISA62_RS19695	COG0612	Peptidase, M16
ISA62_RS19705	COG2982	Protein involved in outer membrane biogenesis
ISA62_RS19710	COG0477	Major facilitator Superfamily
ISA62_RS19715	COG1295	ribonuclease BN
ISA62_RS19720	COG0583	DNA-binding transcription factor activity
ISA62_RS19725	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS19730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA62_RS19740	COG1454	alcohol dehydrogenase
ISA62_RS19750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA62_RS19755	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISA62_RS19760	COG0671	phosphoesterase, PA-phosphatase related
ISA62_RS19780	COG0589	response to stress
ISA62_RS19790	COG0306	phosphate transporter
ISA62_RS19795	COG2081	HI0933 family
ISA62_RS19800	COG2239	Acts as a magnesium transporter
ISA62_RS19815	COG1124	(ABC) transporter
ISA62_RS19825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA62_RS19830	COG0601	transmembrane transport
ISA62_RS19835	COG0747	negative chemotaxis
ISA62_RS19845	COG3479	Phenolic acid decarboxylase
ISA62_RS19885	COG0628	permease
ISA62_RS19890	COG0477	Major facilitator Superfamily
ISA62_RS19900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISA62_RS19915	COG3714	YhhN family
ISA62_RS19925	COG3776	membrane
ISA62_RS19930	COG0742	ribosomal rna small subunit methyltransferase
ISA62_RS19935	COG0552	protein localization to endoplasmic reticulum
ISA62_RS19940	COG2884	Cell division ATP-binding protein ftsE
ISA62_RS19945	COG2177	Part of the ABC transporter FtsEX involved in
ISA62_RS19960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA62_RS19970	COG0683	leucine binding
ISA62_RS19980	COG1704	LemA family
ISA62_RS19990	COG0683	leucine binding
ISA62_RS19995	COG0559	Belongs to the binding-protein-dependent transport system permease family
ISA62_RS20045	COG0584	glycerophosphoryl diester phosphodiesterase
ISA62_RS20055	COG0405	Gamma-glutamyltransferase
ISA62_RS20060	COG1247	-acetyltransferase
ISA62_RS20070	COG0673	inositol 2-dehydrogenase activity
ISA62_RS20075	COG1741	Belongs to the pirin family
ISA62_RS20080	COG1609	Transcriptional regulator
ISA62_RS20085	COG3265	gluconokinase activity
ISA62_RS20090	COG2610	gluconate transmembrane transporter activity
ISA62_RS20100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA62_RS20125	COG0058	SHG alpha-glucan phosphorylase activity
ISA62_RS20130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA62_RS20145	COG1349	DNA-binding transcription factor activity
ISA62_RS20155	COG0058	SHG alpha-glucan phosphorylase activity
ISA62_RS20160	COG1640	4-alpha-glucanotransferase
ISA62_RS20165	COG2610	gluconate transmembrane transporter activity
ISA62_RS20175	COG1040	competence protein
ISA62_RS20200	COG1918	ferrous iron import across plasma membrane
ISA62_RS20205	COG2183	response to ionizing radiation
ISA62_RS20210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA62_RS20235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISA62_RS20240	COG1011	Hydrolase
ISA62_RS20250	COG0494	nUDIX hydrolase
ISA62_RS20255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISA62_RS20280	COG4796	Type ii and iii secretion system protein
ISA62_RS20295	COG3266	domain, Protein
ISA62_RS20300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ISA62_RS20305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA62_RS20330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA62_RS20335	COG0402	S-adenosylhomocysteine deaminase activity
ISA62_RS20340	COG0738	Major facilitator superfamily
ISA62_RS20370	COG1289	transmembrane transporter activity
ISA62_RS20380	COG1765	OsmC-like protein
ISA62_RS20385	COG3954	Phosphoribulokinase
ISA62_RS20395	COG0429	hydrolase of the alpha beta-hydrolase fold
ISA62_RS20400	COG0488	(ABC) transporter
ISA62_RS20415	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISA62_RS20420	COG1047	Peptidyl-prolyl cis-trans
ISA62_RS20430	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA62_RS20435	COG2964	Protein conserved in bacteria
ISA62_RS20490	COG0051	transcription antitermination factor activity, RNA binding
ISA62_RS20515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISA62_RS20530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISA62_RS20595	COG0201	protein transport
ISA62_RS20620	COG0202	RNA polymerase activity
ISA62_RS20635	COG0789	Transcriptional regulator
ISA62_RS20640	COG3036	rescue of stalled ribosome
ISA62_RS20670	COG0758	DNA mediated transformation
ISA62_RS20680	COG0551	DNA topoisomerase type I activity
ISA62_RS20700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA62_RS20735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA62_RS20740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS20745	COG1309	transcriptional regulator
ISA62_RS20765	COG4145	pantothenate transmembrane transporter activity
ISA62_RS20770	COG3924	membrane
ISA62_RS20775	COG0439	Biotin carboxylase
ISA62_RS20780	COG0511	ligase activity, forming carbon-carbon bonds
ISA62_RS20805	COG2200	EAL domain
ISA62_RS20805	COG2199	diguanylate cyclase activity
ISA62_RS20810	COG1077	Cell shape determining protein MreB Mrl
ISA62_RS20815	COG1792	Involved in formation and maintenance of cell shape
ISA62_RS20820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISA62_RS20830	COG1530	ribonuclease E activity
ISA62_RS20835	COG3164	Protein of unknown function
ISA62_RS20840	COG0312	modulator of DNA gyrase
ISA62_RS20845	COG0583	DNA-binding transcription factor activity
ISA62_RS20860	COG1289	transmembrane transporter activity
ISA62_RS20865	COG2732	(Barnase) inhibitor
ISA62_RS20890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA62_RS20895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA62_RS20900	COG3105	Protein conserved in bacteria
ISA62_RS20905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA62_RS20925	COG0625	glutathione transferase activity
ISA62_RS20930	COG2969	positive regulation of protein catabolic process
ISA62_RS20940	COG0493	'glutamate synthase
ISA62_RS20945	COG0070	glutamate synthase
ISA62_RS20945	COG0069	glutamate synthase activity
ISA62_RS20945	COG0067	glutamate synthase
ISA62_RS20950	COG1242	4 iron, 4 sulfur cluster binding
ISA62_RS20955	COG2271	Major facilitator Superfamily
ISA62_RS20960	COG1063	alcohol dehydrogenase
ISA62_RS20965	COG1312	Catalyzes the dehydration of D-mannonate
ISA62_RS20970	COG5002	protein histidine kinase activity
ISA62_RS20970	COG2198	Histidine kinase
ISA62_RS20970	COG0784	Response regulator, receiver
ISA62_RS20975	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISA62_RS20980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA62_RS20985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS20995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS21000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA62_RS21005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISA62_RS21010	COG1137	ATPase activity
ISA62_RS21015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISA62_RS21020	COG3117	lipopolysaccharide transmembrane transporter activity
ISA62_RS21025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISA62_RS21035	COG0530	calcium, potassium:sodium antiporter activity
ISA62_RS21040	COG1127	ABC transporter
ISA62_RS21045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISA62_RS21050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA62_RS21055	COG2854	intermembrane phospholipid transfer
ISA62_RS21060	COG3113	response to antibiotic
ISA62_RS21065	COG5007	Belongs to the BolA IbaG family
ISA62_RS21075	COG3423	Transcriptional regulator
ISA62_RS21080	COG0142	geranyltranstransferase activity
ISA62_RS21095	COG0697	spore germination
ISA62_RS21105	COG2027	D-alanyl-D-alanine carboxypeptidase
ISA62_RS21115	COG1534	Rna-binding protein
ISA62_RS21125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISA62_RS21130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISA62_RS21140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISA62_RS21180	COG0195	Participates in both transcription termination and antitermination
ISA62_RS21225	COG0814	amino acid
ISA62_RS21230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA62_RS21235	COG0826	peptidase U32
ISA62_RS21240	COG0826	peptidase U32
ISA62_RS21245	COG3154	lipid carrier protein
ISA62_RS21250	COG3153	acetyltransferase
ISA62_RS21265	COG0693	protein deglycase activity
ISA62_RS21270	COG0702	epimerase
ISA62_RS21275	COG0701	Predicted permease
ISA62_RS21280	COG2823	Periplasmic or secreted lipoprotein
ISA62_RS21300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISA62_RS21305	COG2721	sulfolactate sulfo-lyase activity
ISA62_RS21310	COG2271	Major facilitator Superfamily
ISA62_RS21320	COG2084	Dehydrogenase
ISA62_RS21325	COG1929	Belongs to the glycerate kinase type-1 family
ISA62_RS21350	COG1741	Belongs to the pirin family
ISA62_RS21355	COG0583	DNA-binding transcription factor activity
ISA62_RS21360	COG3152	Membrane
ISA62_RS21365	COG0435	Glutathione S-transferase
ISA62_RS21370	COG2259	Doxx family
ISA62_RS21380	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISA62_RS21385	COG4575	ribosome binding
ISA62_RS21390	COG1422	Protein of unknown function (DUF1090)
ISA62_RS21400	COG0586	Pfam SNARE associated Golgi protein
ISA62_RS21405	COG2186	Transcriptional regulator
ISA62_RS21410	COG2271	Major facilitator Superfamily
ISA62_RS21420	COG2721	sulfolactate sulfo-lyase activity
ISA62_RS21435	COG0861	Integral membrane protein TerC family
ISA62_RS21440	COG0673	inositol 2-dehydrogenase activity
ISA62_RS21445	COG1451	nucleotide metabolic process
ISA62_RS21465	COG1902	pentaerythritol trinitrate reductase activity
ISA62_RS21465	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISA62_RS21515	COG1695	Transcriptional regulator
ISA62_RS21520	COG2375	cellular response to nickel ion
ISA62_RS21535	COG1461	Dihydroxyacetone kinase
ISA62_RS21540	COG2376	Dihydroxyacetone kinase
ISA62_RS21610	COG3247	response to pH
ISA62_RS21620	COG0784	Response regulator, receiver
ISA62_RS21620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS21620	COG2198	Histidine kinase
ISA62_RS21620	COG2205	protein histidine kinase activity
ISA62_RS21625	COG2197	response regulator
ISA62_RS21650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA62_RS21655	COG0358	DNA primase activity
ISA62_RS21660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISA62_RS21725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA62_RS21740	COG4991	sh3 domain protein
ISA62_RS21745	COG3025	triphosphatase activity
ISA62_RS21770	COG2960	long-chain fatty acid transporting porin activity
ISA62_RS21785	COG3384	dioxygenase
ISA62_RS21790	COG0754	glutathionylspermidine amidase activity
ISA62_RS21805	COG0494	nUDIX hydrolase
ISA62_RS21810	COG3151	Protein conserved in bacteria
ISA62_RS21815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA62_RS21820	COG3150	esterase
ISA62_RS21830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISA62_RS21835	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA62_RS21840	COG0642	Histidine kinase
ISA62_RS21850	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA62_RS21855	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ISA62_RS21860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISA62_RS21865	COG0204	Acyl-transferase
ISA62_RS21870	COG2132	Multicopper oxidase
ISA62_RS21875	COG1032	radical SAM domain protein
ISA62_RS21885	COG0656	L-ascorbic acid biosynthetic process
ISA62_RS21890	COG1979	alcohol dehydrogenase
ISA62_RS21895	COG2207	Transcriptional regulator
ISA62_RS21900	COG0586	Pfam SNARE associated Golgi protein
ISA62_RS21905	COG0626	cystathionine gamma-synthase activity
ISA62_RS21915	COG0848	biopolymer transport protein
ISA62_RS21920	COG2211	Major facilitator Superfamily
ISA62_RS21945	COG0625	glutathione transferase activity
ISA62_RS21960	COG0754	glutathionylspermidine amidase activity
ISA62_RS21965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA62_RS21985	COG0583	DNA-binding transcription factor activity
ISA62_RS21990	COG0626	cystathionine gamma-synthase activity
ISA62_RS22025	COG1811	Na channel or pump
ISA62_RS22030	COG1982	Orn Lys Arg decarboxylase major
ISA62_RS22035	COG2211	Major facilitator Superfamily
ISA62_RS22050	COG1194	a g-specific adenine glycosylase
ISA62_RS22060	COG3171	Protein conserved in bacteria
ISA62_RS22070	COG4214	carbohydrate transport
ISA62_RS22085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA62_RS22100	COG0762	integral membrane protein
ISA62_RS22105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISA62_RS22110	COG2805	Type II/IV secretion system protein
ISA62_RS22130	COG0189	ligase activity
ISA62_RS22135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISA62_RS22140	COG2356	endonuclease I
ISA62_RS22150	COG2814	Major facilitator Superfamily
ISA62_RS22185	COG0501	Belongs to the peptidase M48B family
ISA62_RS22190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA62_RS22205	COG0191	fructose-bisphosphate aldolase activity
ISA62_RS22210	COG0668	transmembrane transport
ISA62_RS22220	COG2968	Membrane
ISA62_RS22235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA62_RS22240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISA62_RS22260	COG0006	proline dipeptidase activity
ISA62_RS22265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA62_RS22270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA62_RS22290	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS22295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA62_RS22315	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS22320	COG1737	Transcriptional regulator
ISA62_RS22330	COG1272	protein, Hemolysin III
ISA62_RS22340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISA62_RS22350	COG0716	FMN binding
ISA62_RS22355	COG4974	Belongs to the 'phage' integrase family
ISA62_RS22365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISA62_RS22390	COG4942	peptidase
ISA62_RS22400	COG2814	Major facilitator Superfamily
ISA62_RS22415	COG0667	Aldo Keto reductase
ISA62_RS22455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA62_RS22460	COG1393	Belongs to the ArsC family
ISA62_RS22480	COG1538	Outer membrane efflux protein
ISA62_RS22485	COG1289	transmembrane transporter activity
ISA62_RS22500	COG3592	Divergent 4Fe-4S mono-cluster
ISA62_RS22505	COG2388	GCN5-related N-acetyl-transferase
ISA62_RS22515	COG3539	Fimbrial protein
ISA62_RS22520	COG3539	Fimbrial protein
ISA62_RS22525	COG3539	Fimbrial protein
ISA62_RS22530	COG3188	usher protein
ISA62_RS22535	COG3121	Chaperone
ISA62_RS22540	COG3539	Fimbrial protein
ISA62_RS22550	COG4974	Belongs to the 'phage' integrase family
ISA62_RS22555	COG0582	viral genome integration into host DNA
ISA62_RS22560	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA62_RS22565	COG1846	Transcriptional regulator
ISA62_RS22570	COG0697	spore germination
ISA62_RS22620	COG0667	Aldo Keto reductase
ISA62_RS22625	COG0814	amino acid
ISA62_RS22640	COG0183	Belongs to the thiolase family
ISA62_RS22650	COG0823	Involved in the tonB-independent uptake of proteins
ISA62_RS22655	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS22660	COG2814	Major facilitator Superfamily
ISA62_RS22695	COG3842	ATPase activity
ISA62_RS22700	COG0395	ABC-type sugar transport system, permease component
ISA62_RS22705	COG1175	transmembrane transport
ISA62_RS22710	COG1917	Cupin 2, conserved barrel domain protein
ISA62_RS22715	COG1794	racemase activity, acting on amino acids and derivatives
ISA62_RS22720	COG0583	DNA-binding transcription factor activity
ISA62_RS22730	COG1609	Transcriptional regulator
ISA62_RS22735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS22740	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS22745	COG2186	Transcriptional regulator
ISA62_RS22755	COG1609	Transcriptional regulator
ISA62_RS22775	COG0667	Aldo Keto reductase
ISA62_RS22785	COG0861	Integral membrane protein TerC family
ISA62_RS22820	COG2165	general secretion pathway protein
ISA62_RS22825	COG4795	General secretion pathway protein
ISA62_RS22835	COG4967	type IV pilus modification protein PilV
ISA62_RS22840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISA62_RS22845	COG1025	Belongs to the peptidase M16 family
ISA62_RS22850	COG1074	ATP-dependent DNA helicase activity
ISA62_RS22855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISA62_RS22865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISA62_RS22865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISA62_RS22870	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA62_RS22875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISA62_RS22905	COG4656	Part of a membrane complex involved in electron transport
ISA62_RS22910	COG1012	belongs to the aldehyde dehydrogenase family
ISA62_RS22910	COG1454	alcohol dehydrogenase
ISA62_RS22940	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ISA62_RS23145	COG2885	chlorophyll binding
ISA62_RS23180	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISA62_RS23185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISA62_RS23190	COG2166	iron-sulfur cluster assembly
ISA62_RS23195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISA62_RS23205	COG0583	DNA-binding transcription factor activity
ISA62_RS23210	COG2363	Small membrane protein
ISA62_RS23220	COG1349	DNA-binding transcription factor activity
ISA62_RS23240	COG0738	Major facilitator superfamily
ISA62_RS23245	COG0235	Class ii aldolase
ISA62_RS23250	COG1454	alcohol dehydrogenase
ISA62_RS23270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA62_RS23285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISA62_RS23290	COG2011	ABC-type metal ion transport system permease component
ISA62_RS23295	COG1464	Belongs to the NlpA lipoprotein family
ISA62_RS23300	COG0477	Major facilitator Superfamily
ISA62_RS23310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA62_RS23315	COG1760	l-serine dehydratase
ISA62_RS23320	COG0814	amino acid
ISA62_RS23325	COG1611	Belongs to the LOG family
ISA62_RS23340	COG3098	single-species biofilm formation
ISA62_RS23345	COG0564	pseudouridine synthase activity
ISA62_RS23350	COG0716	FMN binding
ISA62_RS23355	COG2271	Major facilitator Superfamily
ISA62_RS23360	COG4948	Mandelate Racemase Muconate Lactonizing
ISA62_RS23365	COG4948	Mandelate Racemase Muconate Lactonizing
ISA62_RS23370	COG1929	Belongs to the glycerate kinase type-1 family
ISA62_RS23375	COG3850	Histidine kinase
ISA62_RS23375	COG4999	Histidine kinase
ISA62_RS23375	COG3437	response regulator, receiver
ISA62_RS23375	COG2205	protein histidine kinase activity
ISA62_RS23385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA62_RS23390	COG3956	TIGRFAM MazG family protein
ISA62_RS23410	COG0602	queuosine metabolic process
ISA62_RS23415	COG0720	synthase
ISA62_RS23435	COG2234	aminopeptidase activity
ISA62_RS23495	COG4942	peptidase
ISA62_RS23495	COG1388	LysM domain
ISA62_RS23500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA62_RS23525	COG0163	prenyltransferase activity
ISA62_RS23530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA62_RS23555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA62_RS23560	COG4558	Periplasmic binding protein
ISA62_RS23565	COG3720	iron ion transport
ISA62_RS23585	COG0679	Auxin Efflux Carrier
ISA62_RS23600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA62_RS23605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA62_RS23610	COG1121	(ABC) transporter
ISA62_RS23615	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISA62_RS23620	COG1609	Transcriptional regulator
ISA62_RS23625	COG1940	carbohydrate kinase activity
ISA62_RS23630	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA62_RS23635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS23640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS23645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA62_RS23650	COG4580	involved in the transport of maltose and maltodextrins
ISA62_RS23660	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS23670	COG0309	Hydrogenase expression formation protein (HypE)
ISA62_RS23675	COG0409	Hydrogenase expression formation protein
ISA62_RS23680	COG0298	carbon dioxide binding
ISA62_RS23685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISA62_RS23700	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA62_RS23705	COG0651	ATP synthesis coupled electron transport
ISA62_RS23710	COG0650	Formate hydrogenlyase subunit 4
ISA62_RS23715	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ISA62_RS23715	COG3261	NADH dehydrogenase
ISA62_RS23720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA62_RS23725	COG3260	NADH ubiquinone oxidoreductase 20
ISA62_RS23735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISA62_RS23745	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS23750	COG1263	PTS System
ISA62_RS23750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA62_RS23755	COG1609	Transcriptional regulator
ISA62_RS23760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA62_RS23765	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ISA62_RS23770	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA62_RS23795	COG1349	DNA-binding transcription factor activity
ISA62_RS23800	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA62_RS23805	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS23815	COG3732	PTS system glucitol sorbitol-specific
ISA62_RS23820	COG3730	PTS system glucitol sorbitol-specific
ISA62_RS23825	COG2951	lytic endotransglycosylase activity
ISA62_RS23830	COG1121	(ABC) transporter
ISA62_RS23835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA62_RS23845	COG1546	Belongs to the CinA family
ISA62_RS23865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISA62_RS23900	COG2823	Periplasmic or secreted lipoprotein
ISA62_RS23905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA62_RS23910	COG1238	metal cluster binding
ISA62_RS23930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISA62_RS23935	COG2814	Major facilitator Superfamily
ISA62_RS23940	COG1566	PFAM secretion protein HlyD family protein
ISA62_RS23945	COG1846	Transcriptional regulator
ISA62_RS23955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISA62_RS23965	COG4176	ABC-type proline glycine betaine transport system permease component
ISA62_RS23980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISA62_RS23990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA62_RS23995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA62_RS24000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA62_RS24005	COG4575	ribosome binding
ISA62_RS24020	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA62_RS24035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA62_RS24040	COG0640	Transcriptional regulator
ISA62_RS24050	COG0583	DNA-binding transcription factor activity
ISA62_RS24055	COG3284	Transcriptional regulator
ISA62_RS24065	COG3539	Fimbrial protein
ISA62_RS24070	COG3121	Chaperone
ISA62_RS24090	COG3188	usher protein
ISA62_RS24100	COG3539	Fimbrial protein
ISA62_RS24105	COG2197	response regulator
ISA62_RS24120	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS24130	COG0235	Class ii aldolase
ISA62_RS24140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA62_RS24170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA62_RS24220	COG0431	NADPH-dependent FMN reductase
ISA62_RS24235	COG2271	Major facilitator Superfamily
ISA62_RS24240	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ISA62_RS24245	COG0477	Major facilitator Superfamily
ISA62_RS24250	COG3622	Belongs to the hyi family
ISA62_RS24275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA62_RS24280	COG3708	Transcriptional regulator
ISA62_RS24280	COG2207	Transcriptional regulator
ISA62_RS24320	COG1204	response to ionizing radiation
ISA62_RS24355	COG2003	Belongs to the UPF0758 family
ISA62_RS24395	COG4735	regulation of single-species biofilm formation
ISA62_RS24405	COG3311	Transcriptional regulator
ISA62_RS24415	COG0582	viral genome integration into host DNA
ISA62_RS24425	COG0582	viral genome integration into host DNA
ISA62_RS24510	COG3179	chitinase
ISA62_RS24550	COG4626	Terminase
ISA62_RS24550	COG1802	Transcriptional regulator
ISA62_RS24660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ISA62_RS24685	COG2867	negative regulation of translational initiation
ISA62_RS24700	COG0497	DNA recombination
ISA62_RS24715	COG4536	flavin adenine dinucleotide binding
ISA62_RS24720	COG4137	Cytochrome C assembly protein
ISA62_RS24725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISA62_RS24760	COG2885	chlorophyll binding
ISA62_RS24765	COG2199	diguanylate cyclase activity
ISA62_RS24775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA62_RS24780	COG0287	Prephenate dehydrogenase
ISA62_RS24780	COG1605	Chorismate mutase
ISA62_RS24790	COG1605	Chorismate mutase
ISA62_RS24790	COG0077	Prephenate dehydratase
ISA62_RS24800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA62_RS24805	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA62_RS24820	COG0542	response to heat
ISA62_RS24845	COG0477	Major facilitator Superfamily
ISA62_RS24850	COG5544	Lipoprotein
ISA62_RS24855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA62_RS24865	COG3148	PFAM DTW domain containing protein
ISA62_RS24870	COG3118	belongs to the thioredoxin family
ISA62_RS24875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA62_RS24890	COG0513	Belongs to the DEAD box helicase family
ISA62_RS24900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISA62_RS24915	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ISA62_RS24920	COG3026	antisigma factor binding
ISA62_RS24925	COG3086	response to oxidative stress
ISA62_RS24935	COG0681	Belongs to the peptidase S26 family
ISA62_RS24955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISA62_RS24965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA62_RS24970	COG1737	Transcriptional regulator
ISA62_RS24975	COG0560	Phosphoserine phosphatase
ISA62_RS24990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISA62_RS24990	COG0047	phosphoribosylformylglycinamidine synthase activity
ISA62_RS24995	COG2205	protein histidine kinase activity
ISA62_RS25000	COG3170	Tfp pilus assembly protein FimV
ISA62_RS25005	COG2204	response regulator
ISA62_RS25010	COG0347	Belongs to the P(II) protein family
ISA62_RS25015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA62_RS25015	COG1017	nitric oxide dioxygenase activity
ISA62_RS25025	COG2259	Doxx family
ISA62_RS25030	COG1940	carbohydrate kinase activity
ISA62_RS25035	COG0457	Tetratricopeptide repeat
ISA62_RS25040	COG0477	Major facilitator Superfamily
ISA62_RS25040	COG2814	Major facilitator Superfamily
ISA62_RS25045	COG2017	converts alpha-aldose to the beta-anomer
ISA62_RS25050	COG2814	Major facilitator Superfamily
ISA62_RS25055	COG3711	transcriptional antiterminator
ISA62_RS25060	COG3683	transport system, periplasmic component
ISA62_RS25065	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA62_RS25095	COG0822	iron-sulfur transferase activity
ISA62_RS25115	COG0633	Ferredoxin
ISA62_RS25120	COG2975	iron-sulfur cluster assembly
ISA62_RS25140	COG2897	thiosulfate sulfurtransferase activity
ISA62_RS25145	COG2373	Large extracellular alpha-helical protein
ISA62_RS25150	COG4953	penicillin-binding protein 1C
ISA62_RS25180	COG2976	Protein conserved in bacteria
ISA62_RS25210	COG1645	bacterial-type flagellum-dependent swarming motility
ISA62_RS25220	COG0516	GMP reductase activity
ISA62_RS25220	COG0517	IMP dehydrogenase activity
ISA62_RS25275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA62_RS25305	COG3756	Protein conserved in bacteria
ISA62_RS25445	COG3344	reverse transcriptase
ISA62_RS25470	COG3179	chitinase
ISA62_RS25480	COG3119	arylsulfatase activity
ISA62_RS25485	COG0641	radical SAM
ISA62_RS25505	COG2200	EAL domain
ISA62_RS25520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISA62_RS25535	COG2723	6-phospho-beta-galactosidase activity
ISA62_RS25545	COG2233	PERMEase
ISA62_RS25560	COG1393	Belongs to the ArsC family
ISA62_RS25565	COG4783	chaperone-mediated protein folding
ISA62_RS25575	COG0628	permease
ISA62_RS25580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISA62_RS25585	COG2716	regulation of RNA biosynthetic process
ISA62_RS25595	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISA62_RS25605	COG2321	neutral zinc metallopeptidase
ISA62_RS25610	COG1444	tRNA N-acetyltransferase activity
ISA62_RS25615	COG0400	carboxylic ester hydrolase activity
ISA62_RS25630	COG1393	Belongs to the ArsC family
ISA62_RS25640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA62_RS25645	COG0493	'glutamate synthase
ISA62_RS25645	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA62_RS25655	COG5342	invasion associated locus B
ISA62_RS25660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA62_RS25665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA62_RS25675	COG4810	utilization protein
ISA62_RS25765	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA62_RS25785	COG2837	iron assimilation
ISA62_RS25795	COG4150	thiosulfate binding
ISA62_RS25800	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISA62_RS25805	COG4208	sulfate ABC transporter
ISA62_RS25810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISA62_RS25820	COG4319	ketosteroid isomerase
ISA62_RS25855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISA62_RS25875	COG3530	Putative quorum-sensing-regulated virulence factor
ISA62_RS25880	COG0385	Bile acid
ISA62_RS25885	COG0583	DNA-binding transcription factor activity
ISA62_RS25915	COG3415	Transposase
ISA62_RS25920	COG3415	Transposase
ISA62_RS25935	COG2200	EAL domain
ISA62_RS25935	COG2199	diguanylate cyclase activity
ISA62_RS25940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA62_RS25955	COG0667	Aldo Keto reductase
ISA62_RS25960	COG3961	Belongs to the TPP enzyme family
ISA62_RS25975	COG3279	Response regulator of the LytR AlgR family
ISA62_RS25980	COG3275	phosphorelay sensor kinase activity
ISA62_RS25995	COG0436	Aminotransferase
ISA62_RS26005	COG2807	transmembrane transport
ISA62_RS26010	COG0590	tRNA wobble adenosine to inosine editing
ISA62_RS26065	COG3012	SEC-C Motif Domain Protein
ISA62_RS26065	COG3318	Belongs to the UPF0149 family
ISA62_RS26300	COG5499	transcription regulator containing HTH domain
ISA62_RS26370	COG1475	DNA binding
ISA62_RS26545	COG2197	response regulator
ISA62_RS26590	COG3039	Transposase
ISA62_RS26600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA62_RS26605	COG0501	Belongs to the peptidase M48B family
ISA62_RS26645	COG0071	Belongs to the small heat shock protein (HSP20) family
ISA62_RS26665	COG0542	response to heat
ISA62_RS26670	COG0071	Belongs to the small heat shock protein (HSP20) family
ISA62_RS26705	COG3436	PFAM IS66 Orf2 family protein
ISA62_RS27020	COG0444	Belongs to the ABC transporter superfamily
ISA62_RS27025	COG4608	Belongs to the ABC transporter superfamily
ISA62_RS27030	COG2188	Transcriptional regulator
ISA62_RS27035	COG1363	Peptidase, m42
ISA62_RS27130	COG1028	Short-chain dehydrogenase reductase Sdr
ISA62_RS27135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISA62_RS27140	COG1902	pentaerythritol trinitrate reductase activity
ISA62_RS27150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA62_RS27180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA62_RS27190	COG3039	Transposase
ISA62_RS27275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISA62_RS27305	COG4644	lycopene metabolic process
ISA62_RS27365	COG0747	negative chemotaxis