locus-tag	class	description
ISA64_RS00020	COG0494	nUDIX hydrolase
ISA64_RS00040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISA64_RS00045	COG0849	cell division
ISA64_RS00070	COG0772	Belongs to the SEDS family
ISA64_RS00085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISA64_RS00090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISA64_RS00095	COG0768	penicillin binding
ISA64_RS00115	COG1609	Transcriptional regulator
ISA64_RS00125	COG0028	Belongs to the TPP enzyme family
ISA64_RS00170	COG0738	Major facilitator superfamily
ISA64_RS00180	COG0583	DNA-binding transcription factor activity
ISA64_RS00185	COG2271	Major facilitator Superfamily
ISA64_RS00190	COG2814	Major facilitator Superfamily
ISA64_RS00210	COG1178	ABC-type Fe3 transport system permease component
ISA64_RS00220	COG0586	Pfam SNARE associated Golgi protein
ISA64_RS00240	COG0235	Class ii aldolase
ISA64_RS00245	COG0417	DNA replication proofreading
ISA64_RS00255	COG0564	pseudouridine synthase activity
ISA64_RS00265	COG3493	citrate carrier protein
ISA64_RS00280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISA64_RS00285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISA64_RS00295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA64_RS00340	COG0505	Belongs to the CarA family
ISA64_RS00350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISA64_RS00375	COG1047	Peptidyl-prolyl cis-trans
ISA64_RS00390	COG0196	riboflavin kinase activity
ISA64_RS00400	COG0583	DNA-binding transcription factor activity
ISA64_RS00425	COG4735	regulation of single-species biofilm formation
ISA64_RS00430	COG1584	GPR1 FUN34 yaaH family protein
ISA64_RS00435	COG0477	Major facilitator Superfamily
ISA64_RS00440	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA64_RS00445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA64_RS00450	COG1115	amino acid carrier protein
ISA64_RS00465	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISA64_RS00475	COG0460	homoserine dehydrogenase
ISA64_RS00475	COG0527	aspartate kinase activity
ISA64_RS00485	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ISA64_RS00495	COG0745	RESPONSE REGULATOR receiver
ISA64_RS00500	COG4452	Inner membrane protein CreD
ISA64_RS00505	COG2205	protein histidine kinase activity
ISA64_RS00510	COG0745	RESPONSE REGULATOR receiver
ISA64_RS00515	COG3045	CreA protein
ISA64_RS00520	COG3708	Transcriptional regulator
ISA64_RS00520	COG2207	Transcriptional regulator
ISA64_RS00540	COG0741	lytic transglycosylase activity
ISA64_RS00545	COG0488	(ABC) transporter
ISA64_RS00555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISA64_RS00560	COG0560	Phosphoserine phosphatase
ISA64_RS00565	COG3726	membrane protein affecting hemolysin expression
ISA64_RS00595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA64_RS00600	COG0084	hydrolase, TatD family'
ISA64_RS00605	COG4667	esterase of the alpha-beta hydrolase superfamily
ISA64_RS00615	COG2823	Periplasmic or secreted lipoprotein
ISA64_RS00625	COG1011	Hydrolase
ISA64_RS00630	COG0456	acetyltransferase
ISA64_RS00635	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISA64_RS00670	COG3706	GGDEF domain
ISA64_RS00675	COG4114	ferric iron reductase
ISA64_RS00680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS00680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS00685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA64_RS00690	COG2197	response regulator
ISA64_RS00695	COG2197	response regulator
ISA64_RS00710	COG2966	Psort location CytoplasmicMembrane, score
ISA64_RS00725	COG1484	DNA-dependent DNA replication
ISA64_RS00740	COG5464	transposase or invertase
ISA64_RS00750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA64_RS00755	COG3716	PTS system mannose fructose sorbose family IID component
ISA64_RS00760	COG3715	PTS system
ISA64_RS00775	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA64_RS00775	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISA64_RS00780	COG1214	PFAM Peptidase M22, glycoprotease
ISA64_RS00780	COG0456	acetyltransferase
ISA64_RS00790	COG1737	Transcriptional regulator
ISA64_RS00795	COG0800	Aldolase
ISA64_RS00800	COG3734	2-keto-3-deoxy-galactonokinase
ISA64_RS00805	COG4145	pantothenate transmembrane transporter activity
ISA64_RS00815	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ISA64_RS00835	COG0531	amino acid
ISA64_RS00840	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS00845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA64_RS00860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA64_RS00860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISA64_RS00875	COG1846	Transcriptional regulator
ISA64_RS00885	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA64_RS00895	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS00900	COG3384	dioxygenase
ISA64_RS00910	COG3971	2-oxopent-4-enoate hydratase activity
ISA64_RS00930	COG2368	4-hydroxyphenylacetate
ISA64_RS00935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA64_RS00950	COG1966	Carbon starvation protein
ISA64_RS00955	COG2879	small protein
ISA64_RS00960	COG0523	cobalamin synthesis protein
ISA64_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS00975	COG5464	transposase or invertase
ISA64_RS00980	COG2207	Transcriptional regulator
ISA64_RS00980	COG1917	Cupin 2, conserved barrel domain protein
ISA64_RS00990	COG2733	membrane
ISA64_RS01005	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ISA64_RS01010	COG1924	4 iron, 4 sulfur cluster binding
ISA64_RS01025	COG1566	PFAM secretion protein HlyD family protein
ISA64_RS01035	COG5457	Domain of unknown function (DUF1127)
ISA64_RS01040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA64_RS01050	COG0583	DNA-binding transcription factor activity
ISA64_RS01055	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA64_RS01065	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS01070	COG1129	ABC transporter
ISA64_RS01075	COG1879	ABC-type sugar transport system periplasmic component
ISA64_RS01085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS01090	COG1129	ABC transporter
ISA64_RS01090	COG0842	Transport permease protein
ISA64_RS01095	COG0842	Transport permease protein
ISA64_RS01125	COG2850	peptidyl-arginine hydroxylation
ISA64_RS01140	COG5002	protein histidine kinase activity
ISA64_RS01145	COG0745	RESPONSE REGULATOR receiver
ISA64_RS01150	COG1538	Outer membrane efflux protein
ISA64_RS01155	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS01160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS01165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA64_RS01175	COG3040	lipid binding
ISA64_RS01180	COG0789	Transcriptional regulator
ISA64_RS01190	COG0300	oxidoreductase activity
ISA64_RS01205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA64_RS01225	COG3272	Protein of unknown function (DUF1722)
ISA64_RS01230	COG4580	involved in the transport of maltose and maltodextrins
ISA64_RS01235	COG2115	Belongs to the xylose isomerase family
ISA64_RS01240	COG2211	Major facilitator Superfamily
ISA64_RS01245	COG3507	Belongs to the glycosyl hydrolase 43 family
ISA64_RS01295	COG3157	Type VI secretion system effector, Hcp
ISA64_RS01320	COG2003	Belongs to the UPF0758 family
ISA64_RS01340	COG2378	regulation of single-species biofilm formation
ISA64_RS01345	COG3596	GTP binding
ISA64_RS01405	COG0582	viral genome integration into host DNA
ISA64_RS01415	COG0288	reversible hydration of carbon dioxide
ISA64_RS01420	COG0659	secondary active sulfate transmembrane transporter activity
ISA64_RS01425	COG1064	alcohol dehydrogenase
ISA64_RS01430	COG1175	transmembrane transport
ISA64_RS01435	COG0395	ABC-type sugar transport system, permease component
ISA64_RS01440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA64_RS01445	COG3842	ATPase activity
ISA64_RS01460	COG1082	Xylose isomerase domain protein TIM barrel
ISA64_RS01470	COG3962	Belongs to the TPP enzyme family
ISA64_RS01475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA64_RS01480	COG1737	Transcriptional regulator
ISA64_RS01480	COG0837	glucose binding
ISA64_RS01485	COG3718	enzyme involved in inositol metabolism
ISA64_RS01500	COG0433	COG0433 Predicted ATPase
ISA64_RS01505	COG0795	lipopolysaccharide-transporting ATPase activity
ISA64_RS01510	COG0795	lipopolysaccharide-transporting ATPase activity
ISA64_RS01520	COG2927	DNA polymerase III (CHI subunit)
ISA64_RS01525	COG0525	valine-tRNA ligase activity
ISA64_RS01550	COG2731	YhcH YjgK YiaL family protein
ISA64_RS01585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS01585	COG1263	PTS System
ISA64_RS01590	COG0366	Alpha amylase catalytic
ISA64_RS01595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS01600	COG1486	melibiose metabolic process
ISA64_RS01625	COG0602	queuosine metabolic process
ISA64_RS01630	COG2026	Addiction module toxin, RelE StbE family
ISA64_RS01635	COG3077	Addiction module antitoxin, RelB DinJ family
ISA64_RS01640	COG3711	transcriptional antiterminator
ISA64_RS01640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS01645	COG2706	6-phosphogluconolactonase activity
ISA64_RS01660	COG3964	amidohydrolase
ISA64_RS01700	COG0312	modulator of DNA gyrase
ISA64_RS01725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISA64_RS01735	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS01740	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS01745	COG1129	ABC transporter
ISA64_RS01750	COG1879	ABC-type sugar transport system periplasmic component
ISA64_RS01770	COG2105	PFAM AIG2 family protein
ISA64_RS01775	COG2911	Protein conserved in bacteria
ISA64_RS01780	COG0729	surface antigen
ISA64_RS01790	COG1253	flavin adenine dinucleotide binding
ISA64_RS01815	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISA64_RS01830	COG1733	regulation of RNA biosynthetic process
ISA64_RS01835	COG0702	epimerase
ISA64_RS01845	COG0697	spore germination
ISA64_RS01855	COG1113	amino acid transport
ISA64_RS01860	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA64_RS01865	COG3061	Opacity-associated protein A
ISA64_RS01875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISA64_RS01880	COG2965	DNA replication, synthesis of RNA primer
ISA64_RS01940	COG1073	alpha beta
ISA64_RS01945	COG3650	response to hydrogen peroxide
ISA64_RS01955	COG1960	acyl-CoA dehydrogenase activity
ISA64_RS01960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA64_RS01965	COG0557	exoribonuclease II activity
ISA64_RS01980	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISA64_RS01990	COG0330	HflC and HflK could
ISA64_RS01995	COG0330	HflC and HflK could
ISA64_RS02000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISA64_RS02020	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA64_RS02025	COG0802	atpase or kinase
ISA64_RS02030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISA64_RS02030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISA64_RS02035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISA64_RS02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS02090	COG1053	succinate dehydrogenase
ISA64_RS02095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA64_RS02115	COG2076	Multidrug Resistance protein
ISA64_RS02120	COG5510	response to toxic substance
ISA64_RS02135	COG1509	lysine 2,3-aminomutase activity
ISA64_RS02200	COG0531	amino acid
ISA64_RS02205	COG3030	protein affecting phage T7 exclusion by the F plasmid
ISA64_RS02210	COG1027	Aspartate ammonia-lyase
ISA64_RS02215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA64_RS02230	COG1309	transcriptional regulator
ISA64_RS02280	COG1649	PFAM Uncharacterised BCR, COG1649
ISA64_RS02280	COG0726	polysaccharide deacetylase
ISA64_RS02285	COG1215	transferase activity, transferring glycosyl groups
ISA64_RS02300	COG0861	Integral membrane protein TerC family
ISA64_RS02340	COG1486	melibiose metabolic process
ISA64_RS02345	COG2169	Transcriptional regulator
ISA64_RS02355	COG2824	Alkylphosphonate utilization operon protein PhnA
ISA64_RS02360	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ISA64_RS02365	COG2188	Transcriptional regulator
ISA64_RS02370	COG3624	Phosphonate C-P lyase system protein PhnG
ISA64_RS02375	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISA64_RS02380	COG3626	phosphonate metabolism
ISA64_RS02385	COG3627	carbon phosphorus lyase activity
ISA64_RS02390	COG4107	phosphonate C-P lyase system protein PhnK
ISA64_RS02395	COG4778	phosphonate C-P lyase system protein PhnL
ISA64_RS02400	COG3454	Phosphonate metabolism
ISA64_RS02410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISA64_RS02420	COG4191	Histidine kinase
ISA64_RS02420	COG0784	Response regulator, receiver
ISA64_RS02425	COG1129	ABC transporter
ISA64_RS02430	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS02465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ISA64_RS02470	COG1301	dicarboxylic acid transport
ISA64_RS02480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISA64_RS02485	COG3162	membrane
ISA64_RS02515	COG3539	Fimbrial protein
ISA64_RS02520	COG1346	cytolysis
ISA64_RS02525	COG1380	Effector of murein hydrolase LrgA
ISA64_RS02530	COG0583	DNA-binding transcription factor activity
ISA64_RS02535	COG0025	NhaP-type Na H and K H
ISA64_RS02540	COG2252	PERMEase
ISA64_RS02545	COG0625	glutathione transferase activity
ISA64_RS02550	COG0789	Transcriptional regulator
ISA64_RS02560	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA64_RS02590	COG1234	tRNA 3'-trailer cleavage
ISA64_RS02595	COG1609	Transcriptional regulator
ISA64_RS02600	COG0483	inositol monophosphate 1-phosphatase activity
ISA64_RS02610	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA64_RS02635	COG4771	TonB-dependent receptor
ISA64_RS02640	COG0741	lytic transglycosylase activity
ISA64_RS02655	COG2315	Protein conserved in bacteria
ISA64_RS02660	COG0432	Pfam Uncharacterised protein family UPF0047
ISA64_RS02675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISA64_RS02680	COG0305	Participates in initiation and elongation during chromosome replication
ISA64_RS02695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA64_RS02705	COG0735	belongs to the Fur family
ISA64_RS02710	COG3237	CsbD-like
ISA64_RS02720	COG0534	Mate efflux family protein
ISA64_RS02730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISA64_RS02800	COG0251	oxidation-reduction process
ISA64_RS02810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISA64_RS02820	COG0527	aspartate kinase activity
ISA64_RS02870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISA64_RS02880	COG0456	acetyltransferase
ISA64_RS02910	COG0151	Belongs to the GarS family
ISA64_RS02920	COG4191	Histidine kinase
ISA64_RS02925	COG3678	ATP-independent chaperone mediated protein folding
ISA64_RS02960	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ISA64_RS02975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA64_RS02980	COG2104	thiamine diphosphate biosynthetic process
ISA64_RS02995	COG3706	GGDEF domain
ISA64_RS03005	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA64_RS03010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA64_RS03045	COG0250	Participates in transcription elongation, termination and antitermination
ISA64_RS03120	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISA64_RS03130	COG1739	Uncharacterized protein family UPF0029
ISA64_RS03170	COG0805	protein transport
ISA64_RS03190	COG3165	ubiquinone biosynthetic process from chorismate
ISA64_RS03220	COG0583	DNA-binding transcription factor activity
ISA64_RS03225	COG0697	spore germination
ISA64_RS03230	COG0561	phosphatase activity
ISA64_RS03235	COG2267	carboxylic ester hydrolase activity
ISA64_RS03240	COG1280	lysine exporter protein (LysE YggA)
ISA64_RS03250	COG1280	lysine exporter protein (LysE YggA)
ISA64_RS03280	COG0210	DNA helicase
ISA64_RS03285	COG1011	Hydrolase
ISA64_RS03315	COG3072	Adenylate cyclase
ISA64_RS03330	COG2959	enzyme of heme biosynthesis
ISA64_RS03335	COG3071	HemY protein
ISA64_RS03380	COG2244	polysaccharide biosynthetic process
ISA64_RS03385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISA64_RS03390	COG0456	acetyltransferase
ISA64_RS03395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISA64_RS03400	COG1088	dTDP-glucose 4,6-dehydratase activity
ISA64_RS03405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISA64_RS03410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISA64_RS03420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISA64_RS03425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISA64_RS03430	COG3118	belongs to the thioredoxin family
ISA64_RS03455	COG1811	Na channel or pump
ISA64_RS03465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA64_RS03470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA64_RS03480	COG0583	DNA-binding transcription factor activity
ISA64_RS03485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA64_RS03500	COG3978	acetolactate synthase activity
ISA64_RS03520	COG3085	chromosome segregation
ISA64_RS03595	COG0583	DNA-binding transcription factor activity
ISA64_RS03610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISA64_RS03625	COG3443	Belongs to the bacterial solute-binding protein 9 family
ISA64_RS03630	COG2207	Transcriptional regulator
ISA64_RS03640	COG0371	Dehydrogenase
ISA64_RS03645	COG0697	spore germination
ISA64_RS03655	COG0583	DNA-binding transcription factor activity
ISA64_RS03665	COG0737	Belongs to the 5'-nucleotidase family
ISA64_RS03675	COG0527	aspartate kinase activity
ISA64_RS03675	COG0460	homoserine dehydrogenase
ISA64_RS03680	COG0626	cystathionine gamma-synthase activity
ISA64_RS03695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISA64_RS03700	COG1609	Transcriptional regulator
ISA64_RS03705	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA64_RS03720	COG1575	Belongs to the MenA family. Type 1 subfamily
ISA64_RS03740	COG3678	ATP-independent chaperone mediated protein folding
ISA64_RS03745	COG0745	RESPONSE REGULATOR receiver
ISA64_RS03750	COG2205	protein histidine kinase activity
ISA64_RS03755	COG2258	MOSC domain
ISA64_RS03760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISA64_RS03800	COG1129	ABC transporter
ISA64_RS03805	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS03810	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS03815	COG1454	alcohol dehydrogenase
ISA64_RS03825	COG2211	Major facilitator Superfamily
ISA64_RS03885	COG0205	6-phosphofructokinase activity
ISA64_RS03905	COG0437	4 iron, 4 sulfur cluster binding
ISA64_RS03910	COG2864	formate dehydrogenase
ISA64_RS03925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISA64_RS03935	COG0456	acetyltransferase
ISA64_RS03950	COG1011	Hydrolase
ISA64_RS03965	COG3852	Histidine kinase
ISA64_RS03980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA64_RS04000	COG0204	Acyl-transferase
ISA64_RS04010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISA64_RS04015	COG3084	Protein conserved in bacteria
ISA64_RS04025	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISA64_RS04050	COG2186	Transcriptional regulator
ISA64_RS04055	COG0477	Major facilitator Superfamily
ISA64_RS04060	COG1609	Transcriptional regulator
ISA64_RS04065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA64_RS04075	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS04080	COG1129	ABC transporter
ISA64_RS04110	COG1522	sequence-specific DNA binding
ISA64_RS04115	COG0716	FMN binding
ISA64_RS04130	COG3312	ion transport
ISA64_RS04180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA64_RS04185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISA64_RS04190	COG0573	inorganic phosphate transmembrane transporter activity
ISA64_RS04195	COG0581	inorganic phosphate transmembrane transporter activity
ISA64_RS04200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISA64_RS04205	COG0704	Plays a role in the regulation of phosphate uptake
ISA64_RS04215	COG2382	esterase
ISA64_RS04220	COG0363	glucosamine-6-phosphate deaminase activity
ISA64_RS04225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA64_RS04230	COG2252	PERMEase
ISA64_RS04235	COG0431	NADPH-dependent FMN reductase
ISA64_RS04240	COG2091	lysine biosynthetic process via aminoadipic acid
ISA64_RS04270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISA64_RS04300	COG0187	DNA topoisomerase II activity
ISA64_RS04305	COG0561	phosphatase activity
ISA64_RS04320	COG2186	Transcriptional regulator
ISA64_RS04325	COG3734	2-keto-3-deoxy-galactonokinase
ISA64_RS04330	COG0800	Aldolase
ISA64_RS04340	COG2271	Major facilitator Superfamily
ISA64_RS04345	COG0823	Involved in the tonB-independent uptake of proteins
ISA64_RS04350	COG5645	(Lipo)protein
ISA64_RS04365	COG3645	SOS response
ISA64_RS04375	COG2188	Transcriptional regulator
ISA64_RS04390	COG2149	membrane
ISA64_RS04410	COG2610	gluconate transmembrane transporter activity
ISA64_RS04420	COG0583	DNA-binding transcription factor activity
ISA64_RS04425	COG2814	Major facilitator Superfamily
ISA64_RS04455	COG0028	Belongs to the TPP enzyme family
ISA64_RS04460	COG0440	acetolactate synthase activity
ISA64_RS04465	COG2197	response regulator
ISA64_RS04475	COG2271	Major facilitator Superfamily
ISA64_RS04515	COG2188	Transcriptional regulator
ISA64_RS04540	COG4580	involved in the transport of maltose and maltodextrins
ISA64_RS04545	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA64_RS04550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS04550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS04560	COG1609	Transcriptional regulator
ISA64_RS04570	COG3384	dioxygenase
ISA64_RS04575	COG0583	DNA-binding transcription factor activity
ISA64_RS04580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISA64_RS04585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISA64_RS04590	COG2828	Protein conserved in bacteria
ISA64_RS04605	COG0697	spore germination
ISA64_RS04610	COG1263	PTS System
ISA64_RS04610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS04620	COG2814	Major facilitator Superfamily
ISA64_RS04630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA64_RS04665	COG0583	DNA-binding transcription factor activity
ISA64_RS04690	COG1464	Belongs to the NlpA lipoprotein family
ISA64_RS04705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISA64_RS04715	COG1064	alcohol dehydrogenase
ISA64_RS04745	COG2211	Major facilitator Superfamily
ISA64_RS04750	COG1501	Belongs to the glycosyl hydrolase 31 family
ISA64_RS04760	COG1486	melibiose metabolic process
ISA64_RS04765	COG1263	PTS System
ISA64_RS04765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS04770	COG2982	Protein involved in outer membrane biogenesis
ISA64_RS04775	COG2233	PERMEase
ISA64_RS04780	COG0786	glutamate:sodium symporter activity
ISA64_RS04800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISA64_RS04825	COG3152	Membrane
ISA64_RS04835	COG1494	fructose-1,6-bisphosphatase
ISA64_RS04840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISA64_RS04845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA64_RS04850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA64_RS04870	COG2860	membrane
ISA64_RS04880	COG2169	Transcriptional regulator
ISA64_RS04880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA64_RS04885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ISA64_RS04890	COG1561	YicC-like family, N-terminal region
ISA64_RS04910	COG1131	(ABC) transporter
ISA64_RS04915	COG0842	Transport permease protein
ISA64_RS04940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISA64_RS04975	COG1519	Transferase
ISA64_RS04980	COG1216	Glycosyl transferase, family 2
ISA64_RS04985	COG0438	transferase activity, transferring glycosyl groups
ISA64_RS04995	COG0859	PFAM glycosyl transferase family 9
ISA64_RS05020	COG0859	PFAM glycosyl transferase family 9
ISA64_RS05035	COG0156	8-amino-7-oxononanoate synthase activity
ISA64_RS05045	COG0463	Glycosyl transferase, family 2
ISA64_RS05050	COG2861	carbohydrate metabolic process
ISA64_RS05055	COG4942	peptidase
ISA64_RS05065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA64_RS05070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA64_RS05090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISA64_RS05100	COG2186	Transcriptional regulator
ISA64_RS05120	COG3722	fumarate hydratase activity
ISA64_RS05140	COG0625	glutathione transferase activity
ISA64_RS05150	COG3276	selenocysteine insertion sequence binding
ISA64_RS05155	COG1414	Transcriptional regulator
ISA64_RS05160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA64_RS05165	COG3977	Valine--pyruvate aminotransferase
ISA64_RS05170	COG0366	Alpha amylase catalytic
ISA64_RS05175	COG2992	FlgJ-related protein
ISA64_RS05180	COG1609	Transcriptional regulator
ISA64_RS05180	COG2207	Transcriptional regulator
ISA64_RS05185	COG4214	carbohydrate transport
ISA64_RS05195	COG4213	ABC transporter substrate-binding protein
ISA64_RS05210	COG4682	membrane
ISA64_RS05215	COG4682	membrane
ISA64_RS05220	COG3274	enterobacterial common antigen metabolic process
ISA64_RS05245	COG0488	(ABC) transporter
ISA64_RS05250	COG1278	Cold shock
ISA64_RS05255	COG2944	sequence-specific DNA binding
ISA64_RS05260	COG2814	Major facilitator Superfamily
ISA64_RS05280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA64_RS05290	COG1609	Transcriptional regulator
ISA64_RS05295	COG2885	chlorophyll binding
ISA64_RS05300	COG0243	molybdopterin cofactor binding
ISA64_RS05305	COG0456	acetyltransferase
ISA64_RS05310	COG2818	Glycosylase
ISA64_RS05315	COG5571	outer membrane autotransporter
ISA64_RS05320	COG2223	nitrite transmembrane transporter activity
ISA64_RS05345	COG0747	negative chemotaxis
ISA64_RS05350	COG0601	transmembrane transport
ISA64_RS05355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA64_RS05360	COG0444	Belongs to the ABC transporter superfamily
ISA64_RS05365	COG4608	Belongs to the ABC transporter superfamily
ISA64_RS05380	COG2894	cell division
ISA64_RS05390	COG1215	transferase activity, transferring glycosyl groups
ISA64_RS05395	COG0457	Tetratricopeptide repeat
ISA64_RS05410	COG2194	sulfuric ester hydrolase activity
ISA64_RS05440	COG1215	transferase activity, transferring glycosyl groups
ISA64_RS05445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISA64_RS05450	COG3118	belongs to the thioredoxin family
ISA64_RS05450	COG0457	Tetratricopeptide repeat
ISA64_RS05455	COG2199	diguanylate cyclase activity
ISA64_RS05455	COG2200	EAL domain
ISA64_RS05465	COG0612	Peptidase, M16
ISA64_RS05475	COG2982	Protein involved in outer membrane biogenesis
ISA64_RS05480	COG0477	Major facilitator Superfamily
ISA64_RS05485	COG1295	ribonuclease BN
ISA64_RS05490	COG0583	DNA-binding transcription factor activity
ISA64_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS05510	COG1454	alcohol dehydrogenase
ISA64_RS05520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA64_RS05525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISA64_RS05530	COG0671	phosphoesterase, PA-phosphatase related
ISA64_RS05550	COG0589	response to stress
ISA64_RS05560	COG0306	phosphate transporter
ISA64_RS05565	COG2081	HI0933 family
ISA64_RS05570	COG2239	Acts as a magnesium transporter
ISA64_RS05580	COG1124	(ABC) transporter
ISA64_RS05590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA64_RS05595	COG0601	transmembrane transport
ISA64_RS05600	COG0747	negative chemotaxis
ISA64_RS05610	COG3479	Phenolic acid decarboxylase
ISA64_RS05650	COG0628	permease
ISA64_RS05655	COG0477	Major facilitator Superfamily
ISA64_RS05665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISA64_RS05680	COG3714	YhhN family
ISA64_RS05690	COG3776	membrane
ISA64_RS05695	COG0742	ribosomal rna small subunit methyltransferase
ISA64_RS05700	COG0552	protein localization to endoplasmic reticulum
ISA64_RS05705	COG2884	Cell division ATP-binding protein ftsE
ISA64_RS05710	COG2177	Part of the ABC transporter FtsEX involved in
ISA64_RS05725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA64_RS05735	COG0683	leucine binding
ISA64_RS05745	COG0683	leucine binding
ISA64_RS05750	COG0559	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS05800	COG0584	glycerophosphoryl diester phosphodiesterase
ISA64_RS05810	COG0405	Gamma-glutamyltransferase
ISA64_RS05815	COG1247	-acetyltransferase
ISA64_RS05825	COG0673	inositol 2-dehydrogenase activity
ISA64_RS05830	COG1741	Belongs to the pirin family
ISA64_RS05835	COG1609	Transcriptional regulator
ISA64_RS05840	COG3265	gluconokinase activity
ISA64_RS05845	COG2610	gluconate transmembrane transporter activity
ISA64_RS05855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA64_RS05880	COG0058	SHG alpha-glucan phosphorylase activity
ISA64_RS05895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA64_RS05910	COG1349	DNA-binding transcription factor activity
ISA64_RS05920	COG0058	SHG alpha-glucan phosphorylase activity
ISA64_RS05925	COG1640	4-alpha-glucanotransferase
ISA64_RS05930	COG2610	gluconate transmembrane transporter activity
ISA64_RS05940	COG1040	competence protein
ISA64_RS05965	COG1918	ferrous iron import across plasma membrane
ISA64_RS05970	COG2183	response to ionizing radiation
ISA64_RS05975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA64_RS06000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISA64_RS06005	COG1011	Hydrolase
ISA64_RS06015	COG0494	nUDIX hydrolase
ISA64_RS06020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISA64_RS06045	COG4796	Type ii and iii secretion system protein
ISA64_RS06060	COG3266	domain, Protein
ISA64_RS06065	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ISA64_RS06070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA64_RS06095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA64_RS06100	COG0402	S-adenosylhomocysteine deaminase activity
ISA64_RS06105	COG0738	Major facilitator superfamily
ISA64_RS06130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA64_RS06135	COG1289	transmembrane transporter activity
ISA64_RS06145	COG1765	OsmC-like protein
ISA64_RS06150	COG3954	Phosphoribulokinase
ISA64_RS06160	COG0429	hydrolase of the alpha beta-hydrolase fold
ISA64_RS06165	COG0488	(ABC) transporter
ISA64_RS06180	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISA64_RS06185	COG1047	Peptidyl-prolyl cis-trans
ISA64_RS06195	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA64_RS06200	COG2964	Protein conserved in bacteria
ISA64_RS06255	COG0051	transcription antitermination factor activity, RNA binding
ISA64_RS06280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISA64_RS06295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISA64_RS06360	COG0201	protein transport
ISA64_RS06385	COG0202	RNA polymerase activity
ISA64_RS06400	COG0789	Transcriptional regulator
ISA64_RS06405	COG3036	rescue of stalled ribosome
ISA64_RS06435	COG0758	DNA mediated transformation
ISA64_RS06445	COG0551	DNA topoisomerase type I activity
ISA64_RS06465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA64_RS06500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA64_RS06505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS06510	COG1309	transcriptional regulator
ISA64_RS06530	COG4145	pantothenate transmembrane transporter activity
ISA64_RS06535	COG3924	membrane
ISA64_RS06540	COG0439	Biotin carboxylase
ISA64_RS06545	COG0511	ligase activity, forming carbon-carbon bonds
ISA64_RS06570	COG2200	EAL domain
ISA64_RS06570	COG2199	diguanylate cyclase activity
ISA64_RS06575	COG1077	Cell shape determining protein MreB Mrl
ISA64_RS06580	COG1792	Involved in formation and maintenance of cell shape
ISA64_RS06585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISA64_RS06595	COG1530	ribonuclease E activity
ISA64_RS06600	COG3164	Protein of unknown function
ISA64_RS06605	COG0312	modulator of DNA gyrase
ISA64_RS06610	COG0583	DNA-binding transcription factor activity
ISA64_RS06625	COG1289	transmembrane transporter activity
ISA64_RS06630	COG2732	(Barnase) inhibitor
ISA64_RS06655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA64_RS06660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA64_RS06665	COG3105	Protein conserved in bacteria
ISA64_RS06670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA64_RS06690	COG0625	glutathione transferase activity
ISA64_RS06695	COG2969	positive regulation of protein catabolic process
ISA64_RS06705	COG0493	'glutamate synthase
ISA64_RS06710	COG0070	glutamate synthase
ISA64_RS06710	COG0069	glutamate synthase activity
ISA64_RS06710	COG0067	glutamate synthase
ISA64_RS06715	COG1242	4 iron, 4 sulfur cluster binding
ISA64_RS06720	COG2271	Major facilitator Superfamily
ISA64_RS06725	COG1063	alcohol dehydrogenase
ISA64_RS06730	COG1312	Catalyzes the dehydration of D-mannonate
ISA64_RS06735	COG0784	Response regulator, receiver
ISA64_RS06735	COG2198	Histidine kinase
ISA64_RS06735	COG5002	protein histidine kinase activity
ISA64_RS06740	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISA64_RS06745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA64_RS06750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS06760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS06765	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA64_RS06770	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISA64_RS06775	COG1137	ATPase activity
ISA64_RS06780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISA64_RS06785	COG3117	lipopolysaccharide transmembrane transporter activity
ISA64_RS06790	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISA64_RS06800	COG0530	calcium, potassium:sodium antiporter activity
ISA64_RS06805	COG1127	ABC transporter
ISA64_RS06810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISA64_RS06815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA64_RS06820	COG2854	intermembrane phospholipid transfer
ISA64_RS06825	COG3113	response to antibiotic
ISA64_RS06830	COG5007	Belongs to the BolA IbaG family
ISA64_RS06840	COG3423	Transcriptional regulator
ISA64_RS06845	COG0142	geranyltranstransferase activity
ISA64_RS06860	COG0697	spore germination
ISA64_RS06870	COG2027	D-alanyl-D-alanine carboxypeptidase
ISA64_RS06880	COG1534	Rna-binding protein
ISA64_RS06890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISA64_RS06895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISA64_RS06905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISA64_RS06945	COG0195	Participates in both transcription termination and antitermination
ISA64_RS06990	COG0814	amino acid
ISA64_RS06995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA64_RS07000	COG0826	peptidase U32
ISA64_RS07005	COG0826	peptidase U32
ISA64_RS07010	COG3154	lipid carrier protein
ISA64_RS07015	COG3153	acetyltransferase
ISA64_RS07030	COG0693	protein deglycase activity
ISA64_RS07035	COG0702	epimerase
ISA64_RS07040	COG0701	Predicted permease
ISA64_RS07045	COG2823	Periplasmic or secreted lipoprotein
ISA64_RS07065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISA64_RS07070	COG2721	sulfolactate sulfo-lyase activity
ISA64_RS07075	COG2271	Major facilitator Superfamily
ISA64_RS07085	COG2084	Dehydrogenase
ISA64_RS07090	COG1929	Belongs to the glycerate kinase type-1 family
ISA64_RS07115	COG1741	Belongs to the pirin family
ISA64_RS07120	COG0583	DNA-binding transcription factor activity
ISA64_RS07125	COG3152	Membrane
ISA64_RS07130	COG0435	Glutathione S-transferase
ISA64_RS07135	COG2259	Doxx family
ISA64_RS07145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISA64_RS07150	COG4575	ribosome binding
ISA64_RS07155	COG1422	Protein of unknown function (DUF1090)
ISA64_RS07165	COG0586	Pfam SNARE associated Golgi protein
ISA64_RS07170	COG2186	Transcriptional regulator
ISA64_RS07175	COG2271	Major facilitator Superfamily
ISA64_RS07185	COG2721	sulfolactate sulfo-lyase activity
ISA64_RS07200	COG0861	Integral membrane protein TerC family
ISA64_RS07205	COG0673	inositol 2-dehydrogenase activity
ISA64_RS07210	COG1451	nucleotide metabolic process
ISA64_RS07230	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISA64_RS07230	COG1902	pentaerythritol trinitrate reductase activity
ISA64_RS07280	COG1695	Transcriptional regulator
ISA64_RS07285	COG2375	cellular response to nickel ion
ISA64_RS07300	COG1461	Dihydroxyacetone kinase
ISA64_RS07305	COG2376	Dihydroxyacetone kinase
ISA64_RS07375	COG3247	response to pH
ISA64_RS07385	COG0784	Response regulator, receiver
ISA64_RS07385	COG2198	Histidine kinase
ISA64_RS07385	COG2205	protein histidine kinase activity
ISA64_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS07390	COG2197	response regulator
ISA64_RS07415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA64_RS07420	COG0358	DNA primase activity
ISA64_RS07425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISA64_RS07490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA64_RS07505	COG4991	sh3 domain protein
ISA64_RS07510	COG3025	triphosphatase activity
ISA64_RS07535	COG2960	long-chain fatty acid transporting porin activity
ISA64_RS07550	COG3384	dioxygenase
ISA64_RS07555	COG0754	glutathionylspermidine amidase activity
ISA64_RS07570	COG0494	nUDIX hydrolase
ISA64_RS07575	COG3151	Protein conserved in bacteria
ISA64_RS07580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA64_RS07585	COG3150	esterase
ISA64_RS07595	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISA64_RS07600	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA64_RS07605	COG0642	Histidine kinase
ISA64_RS07615	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA64_RS07620	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ISA64_RS07625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISA64_RS07630	COG0204	Acyl-transferase
ISA64_RS07635	COG2132	Multicopper oxidase
ISA64_RS07640	COG1032	radical SAM domain protein
ISA64_RS07650	COG0656	L-ascorbic acid biosynthetic process
ISA64_RS07655	COG1979	alcohol dehydrogenase
ISA64_RS07660	COG2207	Transcriptional regulator
ISA64_RS07665	COG0586	Pfam SNARE associated Golgi protein
ISA64_RS07670	COG0626	cystathionine gamma-synthase activity
ISA64_RS07680	COG0848	biopolymer transport protein
ISA64_RS07685	COG2211	Major facilitator Superfamily
ISA64_RS07710	COG0625	glutathione transferase activity
ISA64_RS07725	COG0754	glutathionylspermidine amidase activity
ISA64_RS07730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA64_RS07755	COG0626	cystathionine gamma-synthase activity
ISA64_RS07770	COG1811	Na channel or pump
ISA64_RS07775	COG1982	Orn Lys Arg decarboxylase major
ISA64_RS07780	COG2211	Major facilitator Superfamily
ISA64_RS07795	COG1194	a g-specific adenine glycosylase
ISA64_RS07805	COG3171	Protein conserved in bacteria
ISA64_RS07815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA64_RS07830	COG0762	integral membrane protein
ISA64_RS07835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISA64_RS07840	COG2805	Type II/IV secretion system protein
ISA64_RS07860	COG0189	ligase activity
ISA64_RS07865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISA64_RS07870	COG2356	endonuclease I
ISA64_RS07880	COG2814	Major facilitator Superfamily
ISA64_RS07915	COG2146	nitrite reductase [NAD(P)H] activity
ISA64_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS07935	COG1414	Transcriptional regulator
ISA64_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS07970	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ISA64_RS07990	COG0501	Belongs to the peptidase M48B family
ISA64_RS07995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA64_RS08010	COG0191	fructose-bisphosphate aldolase activity
ISA64_RS08015	COG0668	transmembrane transport
ISA64_RS08025	COG2968	Membrane
ISA64_RS08040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA64_RS08045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISA64_RS08065	COG0006	proline dipeptidase activity
ISA64_RS08070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA64_RS08075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA64_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS08100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA64_RS08120	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS08125	COG1737	Transcriptional regulator
ISA64_RS08135	COG1272	protein, Hemolysin III
ISA64_RS08145	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISA64_RS08155	COG0716	FMN binding
ISA64_RS08160	COG4974	Belongs to the 'phage' integrase family
ISA64_RS08170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISA64_RS08190	COG4942	peptidase
ISA64_RS08200	COG2814	Major facilitator Superfamily
ISA64_RS08215	COG0667	Aldo Keto reductase
ISA64_RS08255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA64_RS08260	COG1393	Belongs to the ArsC family
ISA64_RS08275	COG1538	Outer membrane efflux protein
ISA64_RS08280	COG1289	transmembrane transporter activity
ISA64_RS08295	COG3592	Divergent 4Fe-4S mono-cluster
ISA64_RS08300	COG2388	GCN5-related N-acetyl-transferase
ISA64_RS08310	COG3539	Fimbrial protein
ISA64_RS08315	COG3539	Fimbrial protein
ISA64_RS08320	COG3539	Fimbrial protein
ISA64_RS08325	COG3188	usher protein
ISA64_RS08330	COG3121	Chaperone
ISA64_RS08335	COG3539	Fimbrial protein
ISA64_RS08345	COG4974	Belongs to the 'phage' integrase family
ISA64_RS08350	COG0582	viral genome integration into host DNA
ISA64_RS08355	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA64_RS08360	COG1846	Transcriptional regulator
ISA64_RS08365	COG0697	spore germination
ISA64_RS08415	COG0667	Aldo Keto reductase
ISA64_RS08420	COG0814	amino acid
ISA64_RS08435	COG0183	Belongs to the thiolase family
ISA64_RS08445	COG0823	Involved in the tonB-independent uptake of proteins
ISA64_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS08455	COG2814	Major facilitator Superfamily
ISA64_RS08490	COG3842	ATPase activity
ISA64_RS08495	COG0395	ABC-type sugar transport system, permease component
ISA64_RS08500	COG1175	transmembrane transport
ISA64_RS08505	COG1917	Cupin 2, conserved barrel domain protein
ISA64_RS08510	COG1794	racemase activity, acting on amino acids and derivatives
ISA64_RS08515	COG0583	DNA-binding transcription factor activity
ISA64_RS08525	COG1609	Transcriptional regulator
ISA64_RS08530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS08535	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS08540	COG2186	Transcriptional regulator
ISA64_RS08550	COG1609	Transcriptional regulator
ISA64_RS08570	COG0667	Aldo Keto reductase
ISA64_RS08580	COG0861	Integral membrane protein TerC family
ISA64_RS08615	COG2165	general secretion pathway protein
ISA64_RS08620	COG4795	General secretion pathway protein
ISA64_RS08630	COG4967	type IV pilus modification protein PilV
ISA64_RS08635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISA64_RS08640	COG1025	Belongs to the peptidase M16 family
ISA64_RS08645	COG1074	ATP-dependent DNA helicase activity
ISA64_RS08650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISA64_RS08660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISA64_RS08660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISA64_RS08665	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA64_RS08670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISA64_RS08700	COG4656	Part of a membrane complex involved in electron transport
ISA64_RS08705	COG1454	alcohol dehydrogenase
ISA64_RS08705	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS08735	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ISA64_RS08945	COG2885	chlorophyll binding
ISA64_RS08975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISA64_RS08980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISA64_RS08985	COG2166	iron-sulfur cluster assembly
ISA64_RS08990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISA64_RS09000	COG0583	DNA-binding transcription factor activity
ISA64_RS09005	COG2363	Small membrane protein
ISA64_RS09015	COG1349	DNA-binding transcription factor activity
ISA64_RS09035	COG0738	Major facilitator superfamily
ISA64_RS09040	COG0235	Class ii aldolase
ISA64_RS09045	COG1454	alcohol dehydrogenase
ISA64_RS09065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA64_RS09080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISA64_RS09085	COG2011	ABC-type metal ion transport system permease component
ISA64_RS09090	COG1464	Belongs to the NlpA lipoprotein family
ISA64_RS09095	COG0477	Major facilitator Superfamily
ISA64_RS09105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA64_RS09110	COG1760	l-serine dehydratase
ISA64_RS09115	COG0814	amino acid
ISA64_RS09120	COG1611	Belongs to the LOG family
ISA64_RS09135	COG3098	single-species biofilm formation
ISA64_RS09140	COG0564	pseudouridine synthase activity
ISA64_RS09145	COG0716	FMN binding
ISA64_RS09150	COG2271	Major facilitator Superfamily
ISA64_RS09155	COG4948	Mandelate Racemase Muconate Lactonizing
ISA64_RS09160	COG4948	Mandelate Racemase Muconate Lactonizing
ISA64_RS09165	COG1929	Belongs to the glycerate kinase type-1 family
ISA64_RS09170	COG3850	Histidine kinase
ISA64_RS09170	COG4999	Histidine kinase
ISA64_RS09170	COG2205	protein histidine kinase activity
ISA64_RS09170	COG3437	response regulator, receiver
ISA64_RS09180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA64_RS09185	COG3956	TIGRFAM MazG family protein
ISA64_RS09205	COG0602	queuosine metabolic process
ISA64_RS09210	COG0720	synthase
ISA64_RS09230	COG1203	CRISPR-associated helicase, Cas3
ISA64_RS09245	COG1857	crispr-associated protein
ISA64_RS09260	COG1518	maintenance of DNA repeat elements
ISA64_RS09265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA64_RS09280	COG2234	aminopeptidase activity
ISA64_RS09340	COG4942	peptidase
ISA64_RS09340	COG1388	LysM domain
ISA64_RS09345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA64_RS09370	COG0163	prenyltransferase activity
ISA64_RS09375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA64_RS09415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS09420	COG4558	Periplasmic binding protein
ISA64_RS09425	COG3720	iron ion transport
ISA64_RS09445	COG0679	Auxin Efflux Carrier
ISA64_RS09460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA64_RS09465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA64_RS09470	COG1121	(ABC) transporter
ISA64_RS09480	COG1609	Transcriptional regulator
ISA64_RS09485	COG1940	carbohydrate kinase activity
ISA64_RS09490	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA64_RS09495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS09500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS09505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS09510	COG4580	involved in the transport of maltose and maltodextrins
ISA64_RS09520	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS09530	COG0309	Hydrogenase expression formation protein (HypE)
ISA64_RS09535	COG0409	Hydrogenase expression formation protein
ISA64_RS09540	COG0298	carbon dioxide binding
ISA64_RS09545	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISA64_RS09560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA64_RS09565	COG0651	ATP synthesis coupled electron transport
ISA64_RS09570	COG0650	Formate hydrogenlyase subunit 4
ISA64_RS09575	COG3261	NADH dehydrogenase
ISA64_RS09575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ISA64_RS09580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA64_RS09585	COG3260	NADH ubiquinone oxidoreductase 20
ISA64_RS09595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISA64_RS09605	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS09610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS09610	COG1263	PTS System
ISA64_RS09615	COG1609	Transcriptional regulator
ISA64_RS09620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA64_RS09625	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ISA64_RS09630	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA64_RS09655	COG1349	DNA-binding transcription factor activity
ISA64_RS09660	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS09675	COG3732	PTS system glucitol sorbitol-specific
ISA64_RS09680	COG3730	PTS system glucitol sorbitol-specific
ISA64_RS09685	COG2951	lytic endotransglycosylase activity
ISA64_RS09690	COG1121	(ABC) transporter
ISA64_RS09695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA64_RS09700	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISA64_RS09705	COG1546	Belongs to the CinA family
ISA64_RS09725	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISA64_RS09755	COG2823	Periplasmic or secreted lipoprotein
ISA64_RS09760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA64_RS09765	COG1238	metal cluster binding
ISA64_RS09785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISA64_RS09790	COG2814	Major facilitator Superfamily
ISA64_RS09795	COG1566	PFAM secretion protein HlyD family protein
ISA64_RS09800	COG1846	Transcriptional regulator
ISA64_RS09810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISA64_RS09820	COG4176	ABC-type proline glycine betaine transport system permease component
ISA64_RS09835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISA64_RS09845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA64_RS09850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA64_RS09855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA64_RS09860	COG4575	ribosome binding
ISA64_RS09875	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA64_RS09890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA64_RS09895	COG0640	Transcriptional regulator
ISA64_RS09905	COG0583	DNA-binding transcription factor activity
ISA64_RS09910	COG3284	Transcriptional regulator
ISA64_RS09925	COG3121	Chaperone
ISA64_RS09945	COG3188	usher protein
ISA64_RS09955	COG3539	Fimbrial protein
ISA64_RS09960	COG2197	response regulator
ISA64_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS09985	COG0235	Class ii aldolase
ISA64_RS09995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS10030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS10035	COG3708	Transcriptional regulator
ISA64_RS10035	COG2207	Transcriptional regulator
ISA64_RS10065	COG2867	negative regulation of translational initiation
ISA64_RS10080	COG0497	DNA recombination
ISA64_RS10095	COG4536	flavin adenine dinucleotide binding
ISA64_RS10100	COG4137	Cytochrome C assembly protein
ISA64_RS10105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISA64_RS10140	COG2885	chlorophyll binding
ISA64_RS10145	COG2199	diguanylate cyclase activity
ISA64_RS10155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA64_RS10160	COG0287	Prephenate dehydrogenase
ISA64_RS10160	COG1605	Chorismate mutase
ISA64_RS10170	COG0077	Prephenate dehydratase
ISA64_RS10170	COG1605	Chorismate mutase
ISA64_RS10185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA64_RS10200	COG0542	response to heat
ISA64_RS10225	COG0477	Major facilitator Superfamily
ISA64_RS10230	COG5544	Lipoprotein
ISA64_RS10235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA64_RS10245	COG3148	PFAM DTW domain containing protein
ISA64_RS10250	COG3118	belongs to the thioredoxin family
ISA64_RS10255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA64_RS10270	COG0513	Belongs to the DEAD box helicase family
ISA64_RS10280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISA64_RS10295	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ISA64_RS10300	COG3026	antisigma factor binding
ISA64_RS10305	COG3086	response to oxidative stress
ISA64_RS10315	COG0681	Belongs to the peptidase S26 family
ISA64_RS10335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISA64_RS10345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA64_RS10350	COG1737	Transcriptional regulator
ISA64_RS10355	COG0560	Phosphoserine phosphatase
ISA64_RS10370	COG0047	phosphoribosylformylglycinamidine synthase activity
ISA64_RS10370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISA64_RS10375	COG2205	protein histidine kinase activity
ISA64_RS10380	COG3170	Tfp pilus assembly protein FimV
ISA64_RS10385	COG2204	response regulator
ISA64_RS10390	COG0347	Belongs to the P(II) protein family
ISA64_RS10395	COG1017	nitric oxide dioxygenase activity
ISA64_RS10395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA64_RS10405	COG2259	Doxx family
ISA64_RS10410	COG1940	carbohydrate kinase activity
ISA64_RS10415	COG0457	Tetratricopeptide repeat
ISA64_RS10420	COG2814	Major facilitator Superfamily
ISA64_RS10420	COG0477	Major facilitator Superfamily
ISA64_RS10425	COG2017	converts alpha-aldose to the beta-anomer
ISA64_RS10430	COG2814	Major facilitator Superfamily
ISA64_RS10435	COG3711	transcriptional antiterminator
ISA64_RS10440	COG3683	transport system, periplasmic component
ISA64_RS10445	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA64_RS10475	COG0822	iron-sulfur transferase activity
ISA64_RS10495	COG0633	Ferredoxin
ISA64_RS10500	COG2975	iron-sulfur cluster assembly
ISA64_RS10520	COG2897	thiosulfate sulfurtransferase activity
ISA64_RS10525	COG2373	Large extracellular alpha-helical protein
ISA64_RS10530	COG4953	penicillin-binding protein 1C
ISA64_RS10560	COG2976	Protein conserved in bacteria
ISA64_RS10590	COG1645	bacterial-type flagellum-dependent swarming motility
ISA64_RS10600	COG0517	IMP dehydrogenase activity
ISA64_RS10600	COG0516	GMP reductase activity
ISA64_RS10610	COG3119	arylsulfatase activity
ISA64_RS10615	COG0641	radical SAM
ISA64_RS10635	COG2200	EAL domain
ISA64_RS10650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISA64_RS10665	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS10675	COG2233	PERMEase
ISA64_RS10690	COG1393	Belongs to the ArsC family
ISA64_RS10695	COG4783	chaperone-mediated protein folding
ISA64_RS10705	COG0628	permease
ISA64_RS10710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISA64_RS10715	COG2716	regulation of RNA biosynthetic process
ISA64_RS10725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISA64_RS10735	COG2321	neutral zinc metallopeptidase
ISA64_RS10740	COG1444	tRNA N-acetyltransferase activity
ISA64_RS10745	COG0400	carboxylic ester hydrolase activity
ISA64_RS10760	COG1393	Belongs to the ArsC family
ISA64_RS10770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA64_RS10775	COG0493	'glutamate synthase
ISA64_RS10775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA64_RS10785	COG5342	invasion associated locus B
ISA64_RS10790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA64_RS10795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA64_RS10805	COG4810	utilization protein
ISA64_RS10895	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA64_RS10915	COG2837	iron assimilation
ISA64_RS10925	COG4150	thiosulfate binding
ISA64_RS10930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISA64_RS10935	COG4208	sulfate ABC transporter
ISA64_RS10940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISA64_RS10950	COG4319	ketosteroid isomerase
ISA64_RS10985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISA64_RS11005	COG3530	Putative quorum-sensing-regulated virulence factor
ISA64_RS11010	COG0385	Bile acid
ISA64_RS11015	COG0583	DNA-binding transcription factor activity
ISA64_RS11050	COG3415	Transposase
ISA64_RS11055	COG3415	Transposase
ISA64_RS11070	COG2199	diguanylate cyclase activity
ISA64_RS11070	COG2200	EAL domain
ISA64_RS11075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA64_RS11090	COG0667	Aldo Keto reductase
ISA64_RS11095	COG3961	Belongs to the TPP enzyme family
ISA64_RS11110	COG3279	Response regulator of the LytR AlgR family
ISA64_RS11115	COG3275	phosphorelay sensor kinase activity
ISA64_RS11130	COG0436	Aminotransferase
ISA64_RS11140	COG2807	transmembrane transport
ISA64_RS11145	COG0590	tRNA wobble adenosine to inosine editing
ISA64_RS11150	COG0583	DNA-binding transcription factor activity
ISA64_RS11170	COG2116	formate transmembrane transporter activity
ISA64_RS11175	COG2853	Lipoprotein
ISA64_RS11185	COG3691	Protein conserved in bacteria
ISA64_RS11200	COG2062	phosphohistidine phosphatase, SixA
ISA64_RS11225	COG0730	response to heat
ISA64_RS11230	COG3101	peptidyl-lysine hydroxylation
ISA64_RS11245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA64_RS11265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA64_RS11275	COG0586	Pfam SNARE associated Golgi protein
ISA64_RS11285	COG0285	dihydrofolate synthase activity
ISA64_RS11290	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISA64_RS11295	COG1286	toxin biosynthetic process
ISA64_RS11300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISA64_RS11305	COG0163	prenyltransferase activity
ISA64_RS11330	COG4160	amino acid transport
ISA64_RS11335	COG4598	ABC transporter
ISA64_RS11350	COG1090	epimerase
ISA64_RS11355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA64_RS11360	COG0625	glutathione transferase activity
ISA64_RS11365	COG0625	glutathione transferase activity
ISA64_RS11370	COG0622	Phosphoesterase
ISA64_RS11375	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISA64_RS11380	COG0857	belongs to the CobB CobQ family
ISA64_RS11380	COG0280	phosphate acetyltransferase
ISA64_RS11400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA64_RS11405	COG0490	domain, Protein
ISA64_RS11405	COG0471	metal ion transport
ISA64_RS11415	COG0436	Aminotransferase
ISA64_RS11420	COG0583	DNA-binding transcription factor activity
ISA64_RS11465	COG0839	Belongs to the complex I subunit 6 family
ISA64_RS11475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISA64_RS11480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA64_RS11495	COG2153	protein acetylation
ISA64_RS11500	COG1169	isochorismate synthase
ISA64_RS11525	COG0318	PFAM AMP-dependent synthetase and ligase
ISA64_RS11535	COG5464	transposase or invertase
ISA64_RS11550	COG1414	Transcriptional regulator
ISA64_RS11560	COG2271	Major facilitator Superfamily
ISA64_RS11570	COG0247	lactate metabolic process
ISA64_RS11580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA64_RS11585	COG2271	Major facilitator Superfamily
ISA64_RS11590	COG0584	glycerophosphoryl diester phosphodiesterase
ISA64_RS11595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA64_RS11620	COG2205	protein histidine kinase activity
ISA64_RS11620	COG0784	Response regulator, receiver
ISA64_RS11630	COG2198	Histidine kinase
ISA64_RS11630	COG0642	Histidine kinase
ISA64_RS11645	COG2169	Transcriptional regulator
ISA64_RS11645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA64_RS11650	COG3145	DNA-N1-methyladenine dioxygenase activity
ISA64_RS11655	COG4615	Cyclic peptide transporter
ISA64_RS11660	COG2239	Acts as a magnesium transporter
ISA64_RS11665	COG0659	secondary active sulfate transmembrane transporter activity
ISA64_RS11680	COG0628	permease
ISA64_RS11705	COG1349	DNA-binding transcription factor activity
ISA64_RS11710	COG0494	nUDIX hydrolase
ISA64_RS11730	COG1061	Type III restriction enzyme res subunit
ISA64_RS11735	COG1187	pseudouridine synthase activity
ISA64_RS11740	COG2814	Major facilitator Superfamily
ISA64_RS11750	COG4172	Belongs to the ABC transporter superfamily
ISA64_RS11755	COG4239	(ABC) transporter, permease
ISA64_RS11760	COG4174	ABC transporter (Permease)
ISA64_RS11765	COG4166	transmembrane transport
ISA64_RS11770	COG2200	EAL domain
ISA64_RS11775	COG0791	NLP P60 protein
ISA64_RS11780	COG0671	phosphoesterase, PA-phosphatase related
ISA64_RS11785	COG0523	cobalamin synthesis protein
ISA64_RS11790	COG0246	Mannitol dehydrogenase
ISA64_RS11795	COG1312	Catalyzes the dehydration of D-mannonate
ISA64_RS11810	COG2814	Major facilitator Superfamily
ISA64_RS11815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS11815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS11820	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA64_RS11825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA64_RS11825	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISA64_RS11825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA64_RS11835	COG2855	membrane
ISA64_RS11840	COG0583	DNA-binding transcription factor activity
ISA64_RS11845	COG0833	amino acid
ISA64_RS11850	COG4771	TonB-dependent receptor
ISA64_RS11865	COG2311	Membrane
ISA64_RS11880	COG1129	ABC transporter
ISA64_RS11890	COG2949	membrane
ISA64_RS11900	COG1346	cytolysis
ISA64_RS11910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA64_RS11915	COG3659	wide pore channel activity
ISA64_RS11930	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS11935	COG1538	Outer membrane efflux protein
ISA64_RS11940	COG0586	Pfam SNARE associated Golgi protein
ISA64_RS11950	COG1686	Belongs to the peptidase S11 family
ISA64_RS11960	COG0277	FAD linked oxidase domain protein
ISA64_RS11965	COG1472	Belongs to the glycosyl hydrolase 3 family
ISA64_RS11970	COG1732	Glycine betaine
ISA64_RS11975	COG1174	glycine betaine transport
ISA64_RS11980	COG1125	glycine betaine transport
ISA64_RS11985	COG1174	glycine betaine transport
ISA64_RS11995	COG3275	phosphorelay sensor kinase activity
ISA64_RS12005	COG4807	Protein conserved in bacteria
ISA64_RS12025	COG5455	response to cobalt ion
ISA64_RS12030	COG0583	DNA-binding transcription factor activity
ISA64_RS12035	COG2252	PERMEase
ISA64_RS12045	COG0583	DNA-binding transcription factor activity
ISA64_RS12060	COG0351	phosphomethylpyrimidine kinase
ISA64_RS12065	COG1830	Aldolase
ISA64_RS12075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISA64_RS12100	COG1070	Carbohydrate kinase
ISA64_RS12110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA64_RS12115	COG4948	Mandelate Racemase Muconate Lactonizing
ISA64_RS12120	COG0747	negative chemotaxis
ISA64_RS12125	COG0601	transmembrane transport
ISA64_RS12130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA64_RS12135	COG0444	Belongs to the ABC transporter superfamily
ISA64_RS12140	COG4608	Belongs to the ABC transporter superfamily
ISA64_RS12150	COG0826	peptidase U32
ISA64_RS12155	COG0745	RESPONSE REGULATOR receiver
ISA64_RS12160	COG2205	protein histidine kinase activity
ISA64_RS12185	COG1301	dicarboxylic acid transport
ISA64_RS12205	COG5002	protein histidine kinase activity
ISA64_RS12210	COG0443	Heat shock 70 kDa protein
ISA64_RS12215	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISA64_RS12230	COG2982	Protein involved in outer membrane biogenesis
ISA64_RS12235	COG1253	flavin adenine dinucleotide binding
ISA64_RS12280	COG0463	Glycosyl transferase, family 2
ISA64_RS12320	COG2327	Polysaccharide pyruvyl transferase
ISA64_RS12385	COG0438	transferase activity, transferring glycosyl groups
ISA64_RS12410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISA64_RS12440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA64_RS12455	COG0531	amino acid
ISA64_RS12460	COG0640	Transcriptional regulator
ISA64_RS12465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISA64_RS12475	COG2925	Exonuclease
ISA64_RS12490	COG1289	transmembrane transporter activity
ISA64_RS12510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ISA64_RS12520	COG1942	4-Oxalocrotonate Tautomerase
ISA64_RS12525	COG0583	DNA-binding transcription factor activity
ISA64_RS12530	COG0095	Lipoate-protein ligase
ISA64_RS12535	COG0477	Major facilitator Superfamily
ISA64_RS12545	COG5001	Diguanylate cyclase
ISA64_RS12545	COG3300	MHYT domain
ISA64_RS12555	COG3615	Tellurite resistance protein tehB
ISA64_RS12580	COG3706	GGDEF domain
ISA64_RS12630	COG3423	Transcriptional regulator
ISA64_RS12650	COG0534	Mate efflux family protein
ISA64_RS12660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISA64_RS12680	COG0604	alcohol dehydrogenase
ISA64_RS12685	COG1309	transcriptional regulator
ISA64_RS12690	COG0025	NhaP-type Na H and K H
ISA64_RS12740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA64_RS12750	COG1418	mRNA catabolic process
ISA64_RS12755	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISA64_RS12760	COG3727	T/G mismatch-specific endonuclease activity
ISA64_RS12765	COG0697	spore germination
ISA64_RS12770	COG2354	Protein conserved in bacteria
ISA64_RS12800	COG0366	Alpha amylase catalytic
ISA64_RS12805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS12815	COG0765	amino acid transport
ISA64_RS12820	COG1126	abc transporter atp-binding protein
ISA64_RS12825	COG2197	response regulator
ISA64_RS12835	COG2197	response regulator
ISA64_RS12920	COG1403	HNH endonuclease
ISA64_RS12940	COG1724	mRNA binding
ISA64_RS12945	COG1598	PFAM Uncharacterised protein family UPF0150
ISA64_RS12955	COG3772	lysozyme
ISA64_RS12990	COG4626	Terminase
ISA64_RS12990	COG1802	Transcriptional regulator
ISA64_RS13005	COG0616	signal peptide processing
ISA64_RS13105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA64_RS13135	COG0431	NADPH-dependent FMN reductase
ISA64_RS13150	COG3318	Belongs to the UPF0149 family
ISA64_RS13150	COG3012	SEC-C Motif Domain Protein
ISA64_RS13155	COG0814	amino acid
ISA64_RS13165	COG1528	Iron-storage protein
ISA64_RS13180	COG0477	Major facilitator Superfamily
ISA64_RS13190	COG2211	Major facilitator Superfamily
ISA64_RS13200	COG1528	Iron-storage protein
ISA64_RS13210	COG1879	ABC-type sugar transport system periplasmic component
ISA64_RS13220	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS13245	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISA64_RS13255	COG3102	Protein conserved in bacteria
ISA64_RS13275	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISA64_RS13280	COG1801	Protein of unknown function DUF72
ISA64_RS13285	COG1335	isochorismatase
ISA64_RS13295	COG0494	nUDIX hydrolase
ISA64_RS13320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA64_RS13330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISA64_RS13335	COG0739	heme binding
ISA64_RS13340	COG1560	Kdo2-lipid A biosynthetic process
ISA64_RS13350	COG1737	Transcriptional regulator
ISA64_RS13360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISA64_RS13365	COG0129	dihydroxy-acid dehydratase activity
ISA64_RS13370	COG0800	Aldolase
ISA64_RS13380	COG3141	response to X-ray
ISA64_RS13385	COG2979	Protein of unknown function (DUF533)
ISA64_RS13390	COG1770	oligopeptidase
ISA64_RS13395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA64_RS13405	COG2372	response to copper ion
ISA64_RS13410	COG1276	copper resistance
ISA64_RS13425	COG2990	Protein conserved in bacteria
ISA64_RS13450	COG3008	intermembrane lipid transfer
ISA64_RS13455	COG2995	paraquat-inducible protein a
ISA64_RS13460	COG1956	GAF domain-containing protein
ISA64_RS13480	COG2814	Major facilitator Superfamily
ISA64_RS13485	COG1414	Transcriptional regulator
ISA64_RS13515	COG0768	penicillin binding
ISA64_RS13520	COG2226	methyltransferase
ISA64_RS13535	COG3716	PTS system mannose fructose sorbose family IID component
ISA64_RS13540	COG3715	PTS system
ISA64_RS13545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS13545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS13550	COG1253	flavin adenine dinucleotide binding
ISA64_RS13555	COG2200	EAL domain
ISA64_RS13560	COG1760	l-serine dehydratase
ISA64_RS13580	COG0251	oxidation-reduction process
ISA64_RS13585	COG1199	ATP-dependent helicase activity
ISA64_RS13595	COG3065	identical protein binding
ISA64_RS13605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISA64_RS13615	COG2894	cell division
ISA64_RS13630	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA64_RS13660	COG2719	SpoVR family
ISA64_RS13685	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISA64_RS13695	COG4774	siderophore transport
ISA64_RS13710	COG2308	Evidence 4 Homologs of previously reported genes of
ISA64_RS13750	COG0583	DNA-binding transcription factor activity
ISA64_RS13755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA64_RS13770	COG1882	Formate acetyltransferase
ISA64_RS13805	COG0583	DNA-binding transcription factor activity
ISA64_RS13835	COG0583	DNA-binding transcription factor activity
ISA64_RS13850	COG3122	Protein conserved in bacteria
ISA64_RS13870	COG2885	chlorophyll binding
ISA64_RS13935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISA64_RS14025	COG0012	GTP binding
ISA64_RS14045	COG0659	secondary active sulfate transmembrane transporter activity
ISA64_RS14075	COG2890	protein-(glutamine-N5) methyltransferase activity
ISA64_RS14095	COG0387	Pfam Sodium calcium exchanger
ISA64_RS14100	COG4572	Cation transport regulator
ISA64_RS14105	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ISA64_RS14115	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISA64_RS14120	COG3707	response regulator
ISA64_RS14125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA64_RS14135	COG1116	anion transmembrane transporter activity
ISA64_RS14140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA64_RS14140	COG2146	nitrite reductase [NAD(P)H] activity
ISA64_RS14145	COG0243	molybdopterin cofactor binding
ISA64_RS14150	COG4932	domain protein
ISA64_RS14155	COG2197	response regulator
ISA64_RS14160	COG3850	Histidine kinase
ISA64_RS14165	COG2223	nitrite transmembrane transporter activity
ISA64_RS14175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA64_RS14180	COG1140	nitrate reductase beta subunit
ISA64_RS14185	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA64_RS14190	COG2181	nitrate reductase activity
ISA64_RS14200	COG1522	sequence-specific DNA binding
ISA64_RS14245	COG0788	formyltetrahydrofolate deformylase activity
ISA64_RS14255	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISA64_RS14260	COG0745	RESPONSE REGULATOR receiver
ISA64_RS14265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISA64_RS14270	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA64_RS14280	COG1435	thymidine kinase activity
ISA64_RS14285	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS14285	COG1454	alcohol dehydrogenase
ISA64_RS14295	COG2095	MarC family integral membrane protein
ISA64_RS14300	COG4166	transmembrane transport
ISA64_RS14305	COG0601	transmembrane transport
ISA64_RS14310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA64_RS14315	COG0444	Belongs to the ABC transporter superfamily
ISA64_RS14325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA64_RS14345	COG2353	YceI-like domain
ISA64_RS14355	COG2350	Protein conserved in bacteria
ISA64_RS14365	COG3001	Fructosamine kinase
ISA64_RS14375	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA64_RS14380	COG3137	Salt-induced outer membrane protein
ISA64_RS14420	COG0072	phenylalanine-tRNA ligase activity
ISA64_RS14420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISA64_RS14440	COG0583	DNA-binding transcription factor activity
ISA64_RS14460	COG0386	Belongs to the glutathione peroxidase family
ISA64_RS14470	COG0791	NLP P60 protein
ISA64_RS14480	COG4256	Hemin uptake protein
ISA64_RS14485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA64_RS14500	COG0574	Belongs to the PEP-utilizing enzyme family
ISA64_RS14500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA64_RS14510	COG0628	permease
ISA64_RS14515	COG0247	lactate metabolic process
ISA64_RS14515	COG0277	FAD linked oxidase domain protein
ISA64_RS14520	COG2050	protein possibly involved in aromatic compounds catabolism
ISA64_RS14525	COG2261	transglycosylase associated protein
ISA64_RS14550	COG1120	ATPase activity
ISA64_RS14555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS14565	COG0583	DNA-binding transcription factor activity
ISA64_RS14590	COG1304	FMN binding
ISA64_RS14595	COG1309	transcriptional regulator
ISA64_RS14615	COG0316	Belongs to the HesB IscA family
ISA64_RS14620	COG0719	Fe-S assembly protein
ISA64_RS14625	COG0396	ATPase activity
ISA64_RS14630	COG0719	Fe-S assembly protein
ISA64_RS14645	COG1376	ErfK ybiS ycfS ynhG family protein
ISA64_RS14675	COG1309	transcriptional regulator
ISA64_RS14680	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ISA64_RS14680	COG1082	Xylose isomerase domain protein TIM barrel
ISA64_RS14685	COG2271	Major facilitator Superfamily
ISA64_RS14690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA64_RS14700	COG1120	ATPase activity
ISA64_RS14705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS14710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA64_RS14715	COG1414	Transcriptional regulator
ISA64_RS14750	COG2814	Major facilitator Superfamily
ISA64_RS14770	COG0583	DNA-binding transcription factor activity
ISA64_RS14775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA64_RS14795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA64_RS14800	COG1116	anion transmembrane transporter activity
ISA64_RS14805	COG4774	siderophore transport
ISA64_RS14810	COG1120	ATPase activity
ISA64_RS14815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS14820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS14840	COG0765	amino acid transport
ISA64_RS14845	COG1126	abc transporter atp-binding protein
ISA64_RS14885	COG3383	formate dehydrogenase (NAD+) activity
ISA64_RS14890	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ISA64_RS14900	COG1175	transmembrane transport
ISA64_RS14930	COG4133	protoheme IX ABC transporter activity
ISA64_RS14935	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA64_RS14940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA64_RS14955	COG1138	Cytochrome C-type biogenesis protein
ISA64_RS14960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA64_RS14965	COG4235	cytochrome complex assembly
ISA64_RS14965	COG3088	subunit of a heme lyase
ISA64_RS14995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA64_RS15000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISA64_RS15015	COG3850	Histidine kinase
ISA64_RS15015	COG5002	protein histidine kinase activity
ISA64_RS15020	COG0745	RESPONSE REGULATOR receiver
ISA64_RS15035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA64_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS15070	COG2610	gluconate transmembrane transporter activity
ISA64_RS15075	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA64_RS15085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA64_RS15095	COG0583	DNA-binding transcription factor activity
ISA64_RS15125	COG2814	Major facilitator Superfamily
ISA64_RS15140	COG0277	FAD linked oxidase domain protein
ISA64_RS15145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA64_RS15170	COG0402	S-adenosylhomocysteine deaminase activity
ISA64_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS15210	COG0604	alcohol dehydrogenase
ISA64_RS15210	COG3321	synthase
ISA64_RS15240	COG4608	Belongs to the ABC transporter superfamily
ISA64_RS15245	COG0444	Belongs to the ABC transporter superfamily
ISA64_RS15270	COG0346	lactoylglutathione lyase activity
ISA64_RS15275	COG1349	DNA-binding transcription factor activity
ISA64_RS15310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISA64_RS15365	COG0307	riboflavin synthase, alpha
ISA64_RS15370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA64_RS15375	COG2814	Major facilitator Superfamily
ISA64_RS15380	COG0583	DNA-binding transcription factor activity
ISA64_RS15395	COG2814	Major facilitator Superfamily
ISA64_RS15410	COG0791	NLP P60 protein
ISA64_RS15415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISA64_RS15425	COG0346	lactoylglutathione lyase activity
ISA64_RS15430	COG1902	pentaerythritol trinitrate reductase activity
ISA64_RS15435	COG1309	transcriptional regulator
ISA64_RS15440	COG3313	Fe-S protein
ISA64_RS15445	COG4989	oxidoreductase activity
ISA64_RS15450	COG2032	superoxide dismutase activity
ISA64_RS15455	COG1289	transmembrane transporter activity
ISA64_RS15460	COG1566	PFAM secretion protein HlyD family protein
ISA64_RS15475	COG3706	GGDEF domain
ISA64_RS15490	COG3895	Periplasmic Protein
ISA64_RS15505	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISA64_RS15510	COG0625	glutathione transferase activity
ISA64_RS15520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISA64_RS15530	COG4659	FMN binding
ISA64_RS15565	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS15575	COG0673	inositol 2-dehydrogenase activity
ISA64_RS15585	COG3038	cytochrome b561
ISA64_RS15605	COG0583	DNA-binding transcription factor activity
ISA64_RS15610	COG3485	protocatechuate 3,4-dioxygenase
ISA64_RS15615	COG3485	protocatechuate 3,4-dioxygenase
ISA64_RS15620	COG5383	Protein conserved in bacteria
ISA64_RS15625	COG2272	Belongs to the type-B carboxylesterase lipase family
ISA64_RS15640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA64_RS15645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA64_RS15650	COG1275	C4-dicarboxylate transporter malic acid transport protein
ISA64_RS15675	COG0500	methyltransferase
ISA64_RS15690	COG3708	Transcriptional regulator
ISA64_RS15690	COG2207	Transcriptional regulator
ISA64_RS15695	COG3135	benzoate transporter
ISA64_RS15700	COG1396	sequence-specific DNA binding
ISA64_RS15710	COG0826	peptidase U32
ISA64_RS15730	COG1294	oxidase, subunit
ISA64_RS15735	COG1271	oxidase subunit
ISA64_RS15740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA64_RS15745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA64_RS15750	COG3842	ATPase activity
ISA64_RS15755	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA64_RS15760	COG1177	transmembrane transport
ISA64_RS15765	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS15800	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS15805	COG0747	negative chemotaxis
ISA64_RS15815	COG3238	Protein conserved in bacteria
ISA64_RS15820	COG1247	-acetyltransferase
ISA64_RS15830	COG2130	NADP-dependent
ISA64_RS15845	COG3691	Protein conserved in bacteria
ISA64_RS15850	COG1228	amidohydrolase
ISA64_RS15855	COG4772	TonB-dependent receptor
ISA64_RS15880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA64_RS15885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA64_RS15890	COG1473	amidohydrolase
ISA64_RS15895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA64_RS15900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS15910	COG0765	amino acid transport
ISA64_RS15915	COG1126	abc transporter atp-binding protein
ISA64_RS15925	COG0625	glutathione transferase activity
ISA64_RS15945	COG2211	Major facilitator Superfamily
ISA64_RS15960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA64_RS15965	COG3842	ATPase activity
ISA64_RS15970	COG1840	ABC-type Fe3 transport system, periplasmic component
ISA64_RS15975	COG1178	ABC-type Fe3 transport system permease component
ISA64_RS15980	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ISA64_RS15985	COG2181	nitrate reductase activity
ISA64_RS15990	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA64_RS15995	COG1140	nitrate reductase beta subunit
ISA64_RS16000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA64_RS16005	COG2223	nitrite transmembrane transporter activity
ISA64_RS16020	COG1414	Transcriptional regulator
ISA64_RS16025	COG4948	Mandelate Racemase Muconate Lactonizing
ISA64_RS16030	COG4829	muconolactone delta-isomerase
ISA64_RS16035	COG3485	protocatechuate 3,4-dioxygenase
ISA64_RS16045	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ISA64_RS16070	COG0437	4 iron, 4 sulfur cluster binding
ISA64_RS16075	COG2864	formate dehydrogenase
ISA64_RS16090	COG2326	polyphosphate kinase activity
ISA64_RS16100	COG2814	Major facilitator Superfamily
ISA64_RS16110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA64_RS16120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA64_RS16130	COG0747	negative chemotaxis
ISA64_RS16135	COG1064	alcohol dehydrogenase
ISA64_RS16150	COG0488	(ABC) transporter
ISA64_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS16195	COG3729	General stress protein
ISA64_RS16205	COG3685	Protein conserved in bacteria
ISA64_RS16215	COG0366	Alpha amylase catalytic
ISA64_RS16225	COG2323	membrane
ISA64_RS16235	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA64_RS16245	COG1764	response to oxidative stress
ISA64_RS16270	COG3781	membrane
ISA64_RS16275	COG0243	molybdopterin cofactor binding
ISA64_RS16280	COG0583	DNA-binding transcription factor activity
ISA64_RS16285	COG2814	Major facilitator Superfamily
ISA64_RS16290	COG1285	pathogenesis
ISA64_RS16295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA64_RS16305	COG0583	DNA-binding transcription factor activity
ISA64_RS16325	COG0519	Catalyzes the synthesis of GMP from XMP
ISA64_RS16325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISA64_RS16365	COG0596	Alpha beta hydrolase
ISA64_RS16375	COG2205	protein histidine kinase activity
ISA64_RS16390	COG0076	glutamate decarboxylase activity
ISA64_RS16395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA64_RS16400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA64_RS16405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA64_RS16410	COG1116	anion transmembrane transporter activity
ISA64_RS16415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISA64_RS16445	COG3706	GGDEF domain
ISA64_RS16465	COG0402	S-adenosylhomocysteine deaminase activity
ISA64_RS16470	COG1953	Uracil, thiamine, allantoin
ISA64_RS16505	COG1715	Restriction endonuclease
ISA64_RS16520	COG2207	Transcriptional regulator
ISA64_RS16535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA64_RS16560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA64_RS16605	COG0765	amino acid transport
ISA64_RS16615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISA64_RS16625	COG2070	2-Nitropropane dioxygenase
ISA64_RS16630	COG0583	DNA-binding transcription factor activity
ISA64_RS16640	COG1902	pentaerythritol trinitrate reductase activity
ISA64_RS16645	COG4529	Protein conserved in bacteria
ISA64_RS16650	COG0477	Major facilitator Superfamily
ISA64_RS16690	COG1609	Transcriptional regulator
ISA64_RS16695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS16705	COG3037	sugar-specific permease SgaT UlaA
ISA64_RS16710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA64_RS16720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA64_RS16725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA64_RS16725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISA64_RS16725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA64_RS16740	COG0583	DNA-binding transcription factor activity
ISA64_RS16745	COG0583	DNA-binding transcription factor activity
ISA64_RS16750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA64_RS16760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA64_RS16775	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS16785	COG1609	Transcriptional regulator
ISA64_RS16815	COG1652	LysM domain
ISA64_RS16840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISA64_RS16840	COG0456	acetyltransferase
ISA64_RS16850	COG0667	Aldo Keto reductase
ISA64_RS16855	COG0667	Aldo Keto reductase
ISA64_RS16860	COG3386	PFAM SMP-30 Gluconolaconase
ISA64_RS16865	COG0667	Aldo Keto reductase
ISA64_RS16880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA64_RS16900	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS16920	COG4977	sequence-specific DNA binding
ISA64_RS16940	COG4977	sequence-specific DNA binding
ISA64_RS16960	COG1349	DNA-binding transcription factor activity
ISA64_RS16965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA64_RS16970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA64_RS16975	COG0738	Major facilitator superfamily
ISA64_RS17000	COG0183	Belongs to the thiolase family
ISA64_RS17020	COG1929	Belongs to the glycerate kinase type-1 family
ISA64_RS17025	COG3835	regulator
ISA64_RS17045	COG2186	Transcriptional regulator
ISA64_RS17050	COG1263	PTS System
ISA64_RS17050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS17060	COG2814	Major facilitator Superfamily
ISA64_RS17065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS17065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS17080	COG2819	hydrolase of the alpha beta superfamily
ISA64_RS17085	COG3300	MHYT domain
ISA64_RS17085	COG5001	Diguanylate cyclase
ISA64_RS17120	COG3188	usher protein
ISA64_RS17130	COG1649	PFAM Uncharacterised BCR, COG1649
ISA64_RS17135	COG3550	peptidyl-serine autophosphorylation
ISA64_RS17140	COG1396	sequence-specific DNA binding
ISA64_RS17145	COG2351	hydroxyisourate hydrolase activity
ISA64_RS17150	COG3195	allantoin biosynthetic process
ISA64_RS17150	COG3648	Uricase
ISA64_RS17155	COG2233	PERMEase
ISA64_RS17185	COG2207	Transcriptional regulator
ISA64_RS17200	COG4628	conserved protein (DUF2132)
ISA64_RS17220	COG2011	ABC-type metal ion transport system permease component
ISA64_RS17225	COG2070	2-Nitropropane dioxygenase
ISA64_RS17235	COG0477	Major facilitator Superfamily
ISA64_RS17285	COG2199	diguanylate cyclase activity
ISA64_RS17300	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS17305	COG0583	DNA-binding transcription factor activity
ISA64_RS17315	COG0039	L-malate dehydrogenase activity
ISA64_RS17355	COG4977	sequence-specific DNA binding
ISA64_RS17365	COG0697	spore germination
ISA64_RS17370	COG2814	Major facilitator Superfamily
ISA64_RS17400	COG0683	leucine binding
ISA64_RS17405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISA64_RS17440	COG2223	nitrite transmembrane transporter activity
ISA64_RS17445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISA64_RS17460	COG1349	DNA-binding transcription factor activity
ISA64_RS17465	COG2084	Dehydrogenase
ISA64_RS17470	COG3395	kinase activity
ISA64_RS17475	COG0235	Class ii aldolase
ISA64_RS17480	COG3622	Belongs to the hyi family
ISA64_RS17485	COG2610	gluconate transmembrane transporter activity
ISA64_RS17490	COG2207	Transcriptional regulator
ISA64_RS17490	COG3708	Transcriptional regulator
ISA64_RS17505	COG2200	EAL domain
ISA64_RS17510	COG1546	Belongs to the CinA family
ISA64_RS17515	COG0071	Belongs to the small heat shock protein (HSP20) family
ISA64_RS17550	COG2135	peptidase activity
ISA64_RS17555	COG2207	Transcriptional regulator
ISA64_RS17570	COG4221	oxidoreductase activity
ISA64_RS17575	COG1802	Transcriptional regulator
ISA64_RS17580	COG0589	response to stress
ISA64_RS17585	COG0246	Mannitol dehydrogenase
ISA64_RS17590	COG2271	Major facilitator Superfamily
ISA64_RS17605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA64_RS17620	COG0243	molybdopterin cofactor binding
ISA64_RS17625	COG0437	4 iron, 4 sulfur cluster binding
ISA64_RS17630	COG3302	dmso reductase anchor subunit
ISA64_RS17645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISA64_RS17650	COG1940	carbohydrate kinase activity
ISA64_RS17655	COG0583	DNA-binding transcription factor activity
ISA64_RS17660	COG2814	Major facilitator Superfamily
ISA64_RS17665	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISA64_RS17675	COG3591	Belongs to the peptidase S1B family
ISA64_RS17695	COG0628	permease
ISA64_RS17725	COG0679	Auxin Efflux Carrier
ISA64_RS17735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA64_RS17765	COG3290	protein histidine kinase activity
ISA64_RS17770	COG4565	transcriptional regulatory protein
ISA64_RS17790	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA64_RS17790	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA64_RS17800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA64_RS17805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISA64_RS17815	COG0183	Belongs to the thiolase family
ISA64_RS17820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA64_RS17830	COG1414	Transcriptional regulator
ISA64_RS17835	COG2840	Smr protein MutS2
ISA64_RS17850	COG1473	amidohydrolase
ISA64_RS17855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISA64_RS17870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA64_RS17885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISA64_RS17890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISA64_RS17905	COG0531	amino acid
ISA64_RS17915	COG3136	membrane protein required for alginate biosynthesis
ISA64_RS17920	COG0745	RESPONSE REGULATOR receiver
ISA64_RS17930	COG2205	protein histidine kinase activity
ISA64_RS17940	COG0114	fumarate hydratase activity
ISA64_RS17950	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA64_RS17950	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA64_RS17955	COG1482	cell wall glycoprotein biosynthetic process
ISA64_RS17960	COG5339	Protein conserved in bacteria
ISA64_RS17965	COG1609	Transcriptional regulator
ISA64_RS17970	COG1263	PTS System
ISA64_RS17970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS17975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISA64_RS18000	COG2391	methyltransferase activity
ISA64_RS18005	COG0425	Belongs to the sulfur carrier protein TusA family
ISA64_RS18010	COG5562	phage envelope protein
ISA64_RS18015	COG0401	homolog of Blt101
ISA64_RS18020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISA64_RS18025	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS18035	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA64_RS18040	COG0477	Major facilitator Superfamily
ISA64_RS18045	COG1113	amino acid transport
ISA64_RS18050	COG2988	succinylglutamate desuccinylase activity
ISA64_RS18055	COG3724	N-succinylarginine dihydrolase activity
ISA64_RS18060	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS18065	COG3138	arginine N-succinyltransferase
ISA64_RS18070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA64_RS18080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA64_RS18085	COG0667	Aldo Keto reductase
ISA64_RS18090	COG0583	DNA-binding transcription factor activity
ISA64_RS18115	COG4122	O-methyltransferase activity
ISA64_RS18120	COG1643	Atp-dependent helicase
ISA64_RS18135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA64_RS18140	COG3327	negative regulation of DNA-templated transcription, initiation
ISA64_RS18145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISA64_RS18150	COG0183	Belongs to the thiolase family
ISA64_RS18155	COG2050	protein possibly involved in aromatic compounds catabolism
ISA64_RS18160	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA64_RS18165	COG1024	Enoyl-CoA hydratase
ISA64_RS18170	COG1024	Enoyl-CoA hydratase
ISA64_RS18175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA64_RS18180	COG2151	metal-sulfur cluster biosynthetic enzyme
ISA64_RS18185	COG3396	Phenylacetate-CoA oxygenase
ISA64_RS18190	COG3460	Phenylacetate-CoA oxygenase
ISA64_RS18195	COG3396	Phenylacetate-CoA oxygenase
ISA64_RS18200	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS18200	COG2030	dehydratase
ISA64_RS18220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA64_RS18235	COG2072	flavoprotein involved in K transport
ISA64_RS18250	COG1126	abc transporter atp-binding protein
ISA64_RS18260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS18275	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS18280	COG2207	Transcriptional regulator
ISA64_RS18285	COG3784	Protein of unknown function (DUF1318)
ISA64_RS18295	COG2911	Protein conserved in bacteria
ISA64_RS18300	COG0586	Pfam SNARE associated Golgi protein
ISA64_RS18305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA64_RS18310	COG3187	Heat shock protein
ISA64_RS18315	COG3042	response to heat
ISA64_RS18320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA64_RS18320	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISA64_RS18320	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISA64_RS18320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISA64_RS18325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA64_RS18335	COG0589	response to stress
ISA64_RS18340	COG2135	peptidase activity
ISA64_RS18355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISA64_RS18360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISA64_RS18375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ISA64_RS18415	COG1196	nuclear chromosome segregation
ISA64_RS18515	COG5484	DNA packaging
ISA64_RS18515	COG3728	DNA packaging
ISA64_RS18590	COG1484	DNA-dependent DNA replication
ISA64_RS18640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA64_RS18660	COG0582	viral genome integration into host DNA
ISA64_RS18670	COG0513	Belongs to the DEAD box helicase family
ISA64_RS18680	COG1349	DNA-binding transcription factor activity
ISA64_RS18685	COG0673	inositol 2-dehydrogenase activity
ISA64_RS18700	COG1113	amino acid transport
ISA64_RS18705	COG1522	sequence-specific DNA binding
ISA64_RS18715	COG1448	Aminotransferase
ISA64_RS18720	COG2011	ABC-type metal ion transport system permease component
ISA64_RS18735	COG0436	Aminotransferase
ISA64_RS18740	COG0604	alcohol dehydrogenase
ISA64_RS18770	COG0583	DNA-binding transcription factor activity
ISA64_RS18790	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS18795	COG1309	transcriptional regulator
ISA64_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS18915	COG2885	chlorophyll binding
ISA64_RS18940	COG0693	protein deglycase activity
ISA64_RS18945	COG1078	dGTPase activity
ISA64_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS18955	COG0583	DNA-binding transcription factor activity
ISA64_RS18970	COG0656	L-ascorbic acid biosynthetic process
ISA64_RS19000	COG4166	transmembrane transport
ISA64_RS19010	COG2866	Carboxypeptidase
ISA64_RS19015	COG4948	Mandelate Racemase Muconate Lactonizing
ISA64_RS19020	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISA64_RS19025	COG3180	Ammonia monooxygenase
ISA64_RS19035	COG1486	melibiose metabolic process
ISA64_RS19040	COG0583	DNA-binding transcription factor activity
ISA64_RS19050	COG3106	COG3106 Predicted ATPase
ISA64_RS19060	COG1983	PspC domain protein
ISA64_RS19070	COG1842	Phage shock protein A
ISA64_RS19075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA64_RS19085	COG1473	amidohydrolase
ISA64_RS19100	COG0702	epimerase
ISA64_RS19115	COG4171	peptide transport system, permease
ISA64_RS19130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA64_RS19140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISA64_RS19145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA64_RS19145	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA64_RS19160	COG1349	DNA-binding transcription factor activity
ISA64_RS19170	COG0023	Translation Initiation Factor
ISA64_RS19180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISA64_RS19185	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISA64_RS19190	COG0671	phosphoesterase, PA-phosphatase related
ISA64_RS19200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISA64_RS19225	COG0616	signal peptide processing
ISA64_RS19235	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS19240	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISA64_RS19265	COG0583	DNA-binding transcription factor activity
ISA64_RS19275	COG0009	L-threonylcarbamoyladenylate synthase
ISA64_RS19285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISA64_RS19290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA64_RS19290	COG0512	Glutamine amidotransferase of anthranilate synthase
ISA64_RS19295	COG0134	indole-3-glycerol-phosphate synthase activity
ISA64_RS19295	COG0135	phosphoribosylanthranilate isomerase activity
ISA64_RS19350	COG4774	siderophore transport
ISA64_RS19360	COG3047	cAMP biosynthetic process
ISA64_RS19365	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISA64_RS19395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA64_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS19405	COG1988	membrane-bound metal-dependent
ISA64_RS19410	COG1823	symporter activity
ISA64_RS19420	COG0753	catalase activity
ISA64_RS19430	COG1486	melibiose metabolic process
ISA64_RS19435	COG1917	Cupin 2, conserved barrel domain protein
ISA64_RS19435	COG2169	Transcriptional regulator
ISA64_RS19440	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA64_RS19445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS19455	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA64_RS19460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA64_RS19470	COG0322	excinuclease ABC activity
ISA64_RS19475	COG3678	ATP-independent chaperone mediated protein folding
ISA64_RS19485	COG3724	N-succinylarginine dihydrolase activity
ISA64_RS19495	COG3138	arginine N-succinyltransferase
ISA64_RS19505	COG0708	Exodeoxyribonuclease III
ISA64_RS19510	COG0398	Pfam SNARE associated Golgi protein
ISA64_RS19515	COG0398	Pfam SNARE associated Golgi protein
ISA64_RS19520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA64_RS19525	COG4134	Bacterial extracellular solute-binding protein
ISA64_RS19530	COG4135	transport system, permease component
ISA64_RS19535	COG4136	ATPase activity
ISA64_RS19540	COG2897	thiosulfate sulfurtransferase activity
ISA64_RS19545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISA64_RS19550	COG0494	nUDIX hydrolase
ISA64_RS19555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA64_RS19560	COG0604	alcohol dehydrogenase
ISA64_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS19560	COG3321	synthase
ISA64_RS19565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISA64_RS19570	COG0709	Synthesizes selenophosphate from selenide and ATP
ISA64_RS19580	COG0778	Nitroreductase
ISA64_RS19585	COG0616	signal peptide processing
ISA64_RS19590	COG0252	asparaginase activity
ISA64_RS19595	COG1335	isochorismatase
ISA64_RS19610	COG3139	Protein of unknown function (DUF1315)
ISA64_RS19630	COG0656	L-ascorbic acid biosynthetic process
ISA64_RS19635	COG3713	MltA-interacting MipA family protein
ISA64_RS19640	COG2766	serine protein kinase
ISA64_RS19655	COG0386	Belongs to the glutathione peroxidase family
ISA64_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS19685	COG0583	DNA-binding transcription factor activity
ISA64_RS19690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISA64_RS19695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISA64_RS19705	COG0859	PFAM glycosyl transferase family 9
ISA64_RS19710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA64_RS19720	COG2207	Transcriptional regulator
ISA64_RS19725	COG2807	transmembrane transport
ISA64_RS19730	COG0504	CTP synthase activity
ISA64_RS19735	COG1683	Conserved Protein
ISA64_RS19740	COG3189	MarR family transcriptional regulator
ISA64_RS19745	COG3042	response to heat
ISA64_RS19750	COG2199	diguanylate cyclase activity
ISA64_RS19750	COG2203	Gaf domain
ISA64_RS19770	COG3182	Iron-regulated membrane protein
ISA64_RS19780	COG1560	Kdo2-lipid A biosynthetic process
ISA64_RS19790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISA64_RS19795	COG3706	GGDEF domain
ISA64_RS19800	COG0583	DNA-binding transcription factor activity
ISA64_RS19805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA64_RS19835	COG1294	oxidase, subunit
ISA64_RS19840	COG1271	oxidase subunit
ISA64_RS19845	COG3546	catalase activity
ISA64_RS19850	COG3685	Protein conserved in bacteria
ISA64_RS19855	COG3685	Protein conserved in bacteria
ISA64_RS19860	COG3729	General stress protein
ISA64_RS19870	COG1063	alcohol dehydrogenase
ISA64_RS19875	COG3813	Protein conserved in bacteria
ISA64_RS19900	COG0640	Transcriptional regulator
ISA64_RS19905	COG0538	isocitrate dehydrogenase activity
ISA64_RS19910	COG1187	pseudouridine synthase activity
ISA64_RS19930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISA64_RS19950	COG2205	protein histidine kinase activity
ISA64_RS19955	COG2850	peptidyl-arginine hydroxylation
ISA64_RS19975	COG1177	transmembrane transport
ISA64_RS19995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA64_RS20000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA64_RS20005	COG0698	ribose 5-phosphate isomerase
ISA64_RS20020	COG3395	kinase activity
ISA64_RS20035	COG2390	Transcriptional regulator
ISA64_RS20045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISA64_RS20055	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA64_RS20065	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA64_RS20075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISA64_RS20080	COG1388	LysM domain
ISA64_RS20080	COG1376	ErfK ybiS ycfS ynhG family protein
ISA64_RS20095	COG1309	transcriptional regulator
ISA64_RS20110	COG3134	Outer membrane lipoprotein
ISA64_RS20115	COG1252	NADH dehydrogenase
ISA64_RS20140	COG5633	Lipoprotein
ISA64_RS20145	COG0537	adenosine 5'-monophosphoramidase activity
ISA64_RS20155	COG0084	hydrolase, TatD family'
ISA64_RS20160	COG0470	DNA polymerase III
ISA64_RS20170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISA64_RS20175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISA64_RS20180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA64_RS20195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA64_RS20215	COG1399	metal-binding, possibly nucleic acid-binding protein
ISA64_RS20235	COG1530	ribonuclease E activity
ISA64_RS20240	COG0583	DNA-binding transcription factor activity
ISA64_RS20245	COG2814	Major facilitator Superfamily
ISA64_RS20265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA64_RS20310	COG1560	Kdo2-lipid A biosynthetic process
ISA64_RS20325	COG5645	(Lipo)protein
ISA64_RS20360	COG3381	protein complex oligomerization
ISA64_RS20385	COG1309	transcriptional regulator
ISA64_RS20390	COG0583	DNA-binding transcription factor activity
ISA64_RS20400	COG1335	isochorismatase
ISA64_RS20415	COG1702	phosphate starvation-inducible protein PhoH
ISA64_RS20435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA64_RS20445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISA64_RS20460	COG1309	transcriptional regulator
ISA64_RS20495	COG2233	PERMEase
ISA64_RS20505	COG3729	General stress protein
ISA64_RS20535	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS20550	COG0531	amino acid
ISA64_RS20555	COG0174	glutamine synthetase
ISA64_RS20560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISA64_RS20565	COG1396	sequence-specific DNA binding
ISA64_RS20565	COG1917	Cupin 2, conserved barrel domain protein
ISA64_RS20570	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS20575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA64_RS20580	COG0583	DNA-binding transcription factor activity
ISA64_RS20585	COG0473	3-isopropylmalate dehydrogenase activity
ISA64_RS20590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA64_RS20595	COG4638	Rieske (2fe-2S)
ISA64_RS20600	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS20605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA64_RS20630	COG0670	Belongs to the BI1 family
ISA64_RS20645	COG2207	Transcriptional regulator
ISA64_RS20650	COG1881	PFAM PEBP family protein
ISA64_RS20665	COG1832	CoA-binding protein
ISA64_RS20675	COG0210	DNA helicase
ISA64_RS20680	COG3304	Inner membrane component domain
ISA64_RS20685	COG1289	transmembrane transporter activity
ISA64_RS20690	COG3070	regulator of competence-specific genes
ISA64_RS20710	COG1067	ATP-dependent peptidase activity
ISA64_RS20720	COG3130	regulation of translation
ISA64_RS20725	COG3009	Protein conserved in bacteria
ISA64_RS20730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA64_RS20730	COG3008	intermembrane lipid transfer
ISA64_RS20735	COG2995	paraquat-inducible protein a
ISA64_RS20740	COG0488	(ABC) transporter
ISA64_RS20750	COG0633	Ferredoxin
ISA64_RS20750	COG3217	Mosc domain protein beta barrel domain protein
ISA64_RS20765	COG0431	NADPH-dependent FMN reductase
ISA64_RS20770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA64_RS20775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA64_RS20780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA64_RS20790	COG0308	aminopeptidase N
ISA64_RS20800	COG1473	amidohydrolase
ISA64_RS20810	COG0814	amino acid
ISA64_RS20830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA64_RS20835	COG1448	Aminotransferase
ISA64_RS20840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA64_RS20845	COG3108	Peptidase M15
ISA64_RS20850	COG2989	Protein conserved in bacteria
ISA64_RS20860	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ISA64_RS20870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISA64_RS20875	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA64_RS20880	COG3173	Aminoglycoside phosphotransferase
ISA64_RS20895	COG3214	Protein conserved in bacteria
ISA64_RS20910	COG0658	competence protein
ISA64_RS20910	COG2333	competence protein COMEC
ISA64_RS20920	COG0539	negative regulation of cytoplasmic translation
ISA64_RS20940	COG2323	membrane
ISA64_RS20945	COG1944	ATP diphosphatase activity
ISA64_RS20950	COG2116	formate transmembrane transporter activity
ISA64_RS20955	COG1882	Formate acetyltransferase
ISA64_RS20960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA64_RS20965	COG0477	Major facilitator Superfamily
ISA64_RS20970	COG3302	dmso reductase anchor subunit
ISA64_RS20975	COG0437	4 iron, 4 sulfur cluster binding
ISA64_RS20980	COG0243	molybdopterin cofactor binding
ISA64_RS20990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISA64_RS21000	COG1178	ABC-type Fe3 transport system permease component
ISA64_RS21000	COG1674	ftsk spoiiie
ISA64_RS21010	COG0492	ferredoxin-NADP+ reductase activity
ISA64_RS21015	COG4988	ABC transporter
ISA64_RS21020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISA64_RS21035	COG0542	response to heat
ISA64_RS21045	COG1278	Cold shock
ISA64_RS21055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS21060	COG3593	DNA synthesis involved in DNA repair
ISA64_RS21070	COG2431	L-lysine efflux transmembrane transporter activity
ISA64_RS21080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA64_RS21105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA64_RS21110	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA64_RS21115	COG5001	Diguanylate cyclase
ISA64_RS21115	COG4251	negative regulation of phosphorylation
ISA64_RS21115	COG3706	GGDEF domain
ISA64_RS21115	COG2203	Gaf domain
ISA64_RS21125	COG1126	abc transporter atp-binding protein
ISA64_RS21130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS21135	COG4215	(ABC) transporter
ISA64_RS21140	COG4160	amino acid transport
ISA64_RS21145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS21150	COG5002	protein histidine kinase activity
ISA64_RS21155	COG0745	RESPONSE REGULATOR receiver
ISA64_RS21170	COG1177	transmembrane transport
ISA64_RS21175	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA64_RS21180	COG3842	ATPase activity
ISA64_RS21185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA64_RS21200	COG0778	Nitroreductase
ISA64_RS21225	COG3226	Transcriptional regulator
ISA64_RS21230	COG0738	Major facilitator superfamily
ISA64_RS21235	COG0561	phosphatase activity
ISA64_RS21240	COG2814	Major facilitator Superfamily
ISA64_RS21245	COG0671	phosphoesterase, PA-phosphatase related
ISA64_RS21250	COG1349	DNA-binding transcription factor activity
ISA64_RS21255	COG1686	Belongs to the peptidase S11 family
ISA64_RS21265	COG0625	glutathione transferase activity
ISA64_RS21270	COG2133	pyrroloquinoline quinone binding
ISA64_RS21280	COG2223	nitrite transmembrane transporter activity
ISA64_RS21300	COG0747	negative chemotaxis
ISA64_RS21315	COG0303	'Molybdopterin
ISA64_RS21320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA64_RS21325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA64_RS21330	COG1882	Formate acetyltransferase
ISA64_RS21335	COG0561	phosphatase activity
ISA64_RS21345	COG1609	Transcriptional regulator
ISA64_RS21350	COG2271	Major facilitator Superfamily
ISA64_RS21360	COG0488	(ABC) transporter
ISA64_RS21365	COG2365	Tyrosine phosphatase family
ISA64_RS21370	COG1376	ErfK ybiS ycfS ynhG family protein
ISA64_RS21375	COG2188	Transcriptional regulator
ISA64_RS21380	COG2723	6-phospho-beta-galactosidase activity
ISA64_RS21385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA64_RS21400	COG2194	sulfuric ester hydrolase activity
ISA64_RS21405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISA64_RS21420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS21425	COG0765	amino acid transport
ISA64_RS21430	COG1126	abc transporter atp-binding protein
ISA64_RS21435	COG0668	transmembrane transport
ISA64_RS21445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA64_RS21455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISA64_RS21465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA64_RS21470	COG1199	ATP-dependent helicase activity
ISA64_RS21475	COG0513	Belongs to the DEAD box helicase family
ISA64_RS21480	COG3958	Transketolase
ISA64_RS21485	COG3959	Transketolase, thiamine diphosphate binding domain
ISA64_RS21490	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS21495	COG2271	Major facilitator Superfamily
ISA64_RS21505	COG0583	DNA-binding transcription factor activity
ISA64_RS21510	COG1309	transcriptional regulator
ISA64_RS21515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS21520	COG1131	(ABC) transporter
ISA64_RS21525	COG0842	Transport permease protein
ISA64_RS21530	COG0842	Transport permease protein
ISA64_RS21540	COG3568	Endonuclease Exonuclease Phosphatase
ISA64_RS21545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA64_RS21550	COG0392	lysyltransferase activity
ISA64_RS21555	COG0670	Belongs to the BI1 family
ISA64_RS21560	COG0314	molybdopterin synthase activity
ISA64_RS21565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISA64_RS21575	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA64_RS21595	COG0745	RESPONSE REGULATOR receiver
ISA64_RS21600	COG0642	Histidine kinase
ISA64_RS21625	COG2226	methyltransferase
ISA64_RS21640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA64_RS21645	COG1881	PFAM PEBP family protein
ISA64_RS21685	COG4677	pectinesterase activity
ISA64_RS21720	COG0789	Transcriptional regulator
ISA64_RS21725	COG2200	EAL domain
ISA64_RS21750	COG0561	phosphatase activity
ISA64_RS21760	COG4149	molybdate abc transporter
ISA64_RS21765	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISA64_RS21775	COG2005	Transcriptional regulator
ISA64_RS21775	COG3585	molybdate ion transport
ISA64_RS21780	COG1119	ATPase activity
ISA64_RS21790	COG1085	galactose-1-phosphate uridylyltransferase
ISA64_RS21800	COG2017	converts alpha-aldose to the beta-anomer
ISA64_RS21830	COG0471	metal ion transport
ISA64_RS21830	COG0490	domain, Protein
ISA64_RS21835	COG0583	DNA-binding transcription factor activity
ISA64_RS21850	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA64_RS21850	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA64_RS21855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA64_RS21870	COG3201	nicotinamide mononucleotide transporter
ISA64_RS21875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISA64_RS21925	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISA64_RS21930	COG2885	chlorophyll binding
ISA64_RS21940	COG3064	Membrane
ISA64_RS21945	COG0848	biopolymer transport protein
ISA64_RS21950	COG0811	peptide transport
ISA64_RS21955	COG0824	Thioesterase
ISA64_RS21960	COG3790	cyd operon protein YbgE
ISA64_RS21965	COG4890	Cyd operon protein YbgT
ISA64_RS21970	COG1294	oxidase, subunit
ISA64_RS21975	COG1271	oxidase subunit
ISA64_RS21980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISA64_RS21990	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA64_RS21995	COG0567	Dehydrogenase, E1 component
ISA64_RS22000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA64_RS22005	COG1053	succinate dehydrogenase
ISA64_RS22010	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISA64_RS22015	COG2009	succinate dehydrogenase
ISA64_RS22050	COG1984	allophanate hydrolase subunit 2
ISA64_RS22055	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISA64_RS22070	COG0415	Belongs to the DNA photolyase family
ISA64_RS22100	COG2205	protein histidine kinase activity
ISA64_RS22105	COG0745	RESPONSE REGULATOR receiver
ISA64_RS22115	COG0033	Phosphoglucomutase
ISA64_RS22125	COG0596	Alpha beta hydrolase
ISA64_RS22140	COG0735	belongs to the Fur family
ISA64_RS22180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISA64_RS22185	COG1846	Transcriptional regulator
ISA64_RS22185	COG1940	carbohydrate kinase activity
ISA64_RS22190	COG0647	UMP catabolic process
ISA64_RS22195	COG0367	asparagine synthase
ISA64_RS22235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA64_RS22245	COG1702	phosphate starvation-inducible protein PhoH
ISA64_RS22270	COG0765	amino acid transport
ISA64_RS22275	COG0765	amino acid transport
ISA64_RS22280	COG1126	abc transporter atp-binding protein
ISA64_RS22295	COG2888	peptidyl-tyrosine sulfation
ISA64_RS22310	COG1466	dna polymerase III delta subunit
ISA64_RS22325	COG0799	negative regulation of ribosome biogenesis
ISA64_RS22335	COG0768	penicillin binding
ISA64_RS22340	COG0772	Belongs to the SEDS family
ISA64_RS22345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA64_RS22350	COG1686	Belongs to the peptidase S11 family
ISA64_RS22365	COG0583	DNA-binding transcription factor activity
ISA64_RS22380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA64_RS22400	COG3069	C4-dicarboxylate transmembrane transporter activity
ISA64_RS22405	COG3719	Belongs to the RNase T2 family
ISA64_RS22410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA64_RS22430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISA64_RS22435	COG0583	DNA-binding transcription factor activity
ISA64_RS22440	COG3969	phosphoadenosine phosphosulfate
ISA64_RS22445	COG1475	DNA binding
ISA64_RS22450	COG0436	Aminotransferase
ISA64_RS22475	COG1129	ABC transporter
ISA64_RS22480	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS22485	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS22495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA64_RS22510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA64_RS22520	COG0402	S-adenosylhomocysteine deaminase activity
ISA64_RS22530	COG0483	inositol monophosphate 1-phosphatase activity
ISA64_RS22535	COG2271	Major facilitator Superfamily
ISA64_RS22570	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS22575	COG1129	ABC transporter
ISA64_RS22580	COG0371	Dehydrogenase
ISA64_RS22585	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS22600	COG2879	small protein
ISA64_RS22605	COG1966	Carbon starvation protein
ISA64_RS22615	COG1028	Short-chain dehydrogenase reductase Sdr
ISA64_RS22620	COG3433	isochorismatase activity
ISA64_RS22620	COG1535	isochorismatase
ISA64_RS22625	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISA64_RS22630	COG1169	isochorismate synthase
ISA64_RS22635	COG4592	Periplasmic binding protein
ISA64_RS22645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS22650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS22655	COG1120	ATPase activity
ISA64_RS22660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISA64_RS22660	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ISA64_RS22665	COG3251	PFAM MbtH domain protein
ISA64_RS22670	COG2382	esterase
ISA64_RS22675	COG4771	TonB-dependent receptor
ISA64_RS22685	COG1879	ABC-type sugar transport system periplasmic component
ISA64_RS22695	COG1129	ABC transporter
ISA64_RS22700	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS22705	COG5464	transposase or invertase
ISA64_RS22710	COG2390	Transcriptional regulator
ISA64_RS22715	COG3959	Transketolase, thiamine diphosphate binding domain
ISA64_RS22720	COG3958	Transketolase
ISA64_RS22730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISA64_RS22740	COG0583	DNA-binding transcription factor activity
ISA64_RS22745	COG0668	transmembrane transport
ISA64_RS22755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA64_RS22780	COG0747	negative chemotaxis
ISA64_RS22785	COG0601	transmembrane transport
ISA64_RS22790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA64_RS22795	COG0444	Belongs to the ABC transporter superfamily
ISA64_RS22800	COG4608	Belongs to the ABC transporter superfamily
ISA64_RS22805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA64_RS22810	COG4221	oxidoreductase activity
ISA64_RS22820	COG4215	(ABC) transporter
ISA64_RS22825	COG0765	amino acid transport
ISA64_RS22830	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ISA64_RS22845	COG0697	spore germination
ISA64_RS22860	COG4608	Belongs to the ABC transporter superfamily
ISA64_RS22865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA64_RS22875	COG4166	transmembrane transport
ISA64_RS22885	COG3698	Phosphodiester glycosidase
ISA64_RS22925	COG2315	Protein conserved in bacteria
ISA64_RS22930	COG0778	Nitroreductase
ISA64_RS22940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA64_RS22950	COG3716	PTS system mannose fructose sorbose family IID component
ISA64_RS22955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA64_RS22960	COG2222	sugar isomerase
ISA64_RS22965	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA64_RS22965	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISA64_RS22980	COG0477	Major facilitator Superfamily
ISA64_RS22985	COG0668	transmembrane transport
ISA64_RS22990	COG1609	Transcriptional regulator
ISA64_RS23000	COG0673	inositol 2-dehydrogenase activity
ISA64_RS23010	COG2211	Major facilitator Superfamily
ISA64_RS23015	COG1113	amino acid transport
ISA64_RS23030	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS23035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA64_RS23045	COG0531	amino acid
ISA64_RS23060	COG4680	protein conserved in bacteria
ISA64_RS23100	COG0667	Aldo Keto reductase
ISA64_RS23105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS23110	COG1473	amidohydrolase
ISA64_RS23140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS23145	COG1120	ATPase activity
ISA64_RS23150	COG1566	PFAM secretion protein HlyD family protein
ISA64_RS23195	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISA64_RS23200	COG1129	ABC transporter
ISA64_RS23215	COG0673	inositol 2-dehydrogenase activity
ISA64_RS23245	COG3104	oligopeptide transport
ISA64_RS23250	COG1982	Orn Lys Arg decarboxylase major
ISA64_RS23255	COG0531	amino acid
ISA64_RS23260	COG3710	Transcriptional regulator
ISA64_RS23270	COG1560	Kdo2-lipid A biosynthetic process
ISA64_RS23285	COG3188	usher protein
ISA64_RS23290	COG3121	Chaperone
ISA64_RS23295	COG3539	Fimbrial protein
ISA64_RS23460	COG0582	viral genome integration into host DNA
ISA64_RS23475	COG2501	S4 domain
ISA64_RS23485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISA64_RS23500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISA64_RS23505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISA64_RS23525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISA64_RS23530	COG4181	ATPase activity
ISA64_RS23535	COG2755	lipolytic protein G-D-S-L family
ISA64_RS23540	COG0300	oxidoreductase activity
ISA64_RS23545	COG3118	belongs to the thioredoxin family
ISA64_RS23550	COG0390	transport system, permease component
ISA64_RS23555	COG4619	ABC transporter
ISA64_RS23560	COG0330	HflC and HflK could
ISA64_RS23565	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISA64_RS23580	COG3735	TraB family
ISA64_RS23585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA64_RS23595	COG2223	nitrite transmembrane transporter activity
ISA64_RS23600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISA64_RS23600	COG4651	solute:proton antiporter activity
ISA64_RS23605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA64_RS23645	COG2832	Protein of unknown function (DUF454)
ISA64_RS23650	COG3923	Primosomal replication protein n
ISA64_RS23665	COG3264	Mechanosensitive ion channel
ISA64_RS23665	COG1196	nuclear chromosome segregation
ISA64_RS23670	COG1309	transcriptional regulator
ISA64_RS23675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA64_RS23680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA64_RS23695	COG0110	maltose O-acetyltransferase activity
ISA64_RS23745	COG1874	Beta-galactosidase
ISA64_RS23750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISA64_RS23755	COG3833	ABC-type maltose transport systems, permease component
ISA64_RS23760	COG1175	transmembrane transport
ISA64_RS23765	COG2182	Extracellular solute-binding protein
ISA64_RS23775	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA64_RS23790	COG2364	Membrane
ISA64_RS23820	COG3695	enzyme binding
ISA64_RS23825	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISA64_RS23830	COG1946	Acyl-CoA thioesterase
ISA64_RS23835	COG0004	ammonium transporteR
ISA64_RS23840	COG0347	Belongs to the P(II) protein family
ISA64_RS23845	COG1132	(ABC) transporter
ISA64_RS23850	COG1132	(ABC) transporter
ISA64_RS23855	COG1522	sequence-specific DNA binding
ISA64_RS23870	COG4533	DNA binding
ISA64_RS23880	COG0824	Thioesterase
ISA64_RS23885	COG1555	photosystem II stabilization
ISA64_RS23890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA64_RS23895	COG0776	regulation of translation
ISA64_RS23900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISA64_RS23920	COG0271	Belongs to the BolA IbaG family
ISA64_RS23925	COG3056	Lipoprotein
ISA64_RS23930	COG2223	nitrite transmembrane transporter activity
ISA64_RS23935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISA64_RS23940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISA64_RS23945	COG1845	cytochrome c oxidase, subunit III
ISA64_RS23950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISA64_RS23965	COG1414	Transcriptional regulator
ISA64_RS23970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA64_RS23975	COG1053	succinate dehydrogenase
ISA64_RS23985	COG1053	succinate dehydrogenase
ISA64_RS24000	COG0673	inositol 2-dehydrogenase activity
ISA64_RS24005	COG2814	Major facilitator Superfamily
ISA64_RS24015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISA64_RS24020	COG0693	protein deglycase activity
ISA64_RS24040	COG0142	geranyltranstransferase activity
ISA64_RS24050	COG0667	Aldo Keto reductase
ISA64_RS24055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISA64_RS24075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA64_RS24075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA64_RS24085	COG4238	major outer membrane lipoprotein
ISA64_RS24105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA64_RS24110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA64_RS24115	COG1862	Preprotein translocase
ISA64_RS24140	COG0450	alkyl hydroperoxide reductase
ISA64_RS24145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS24160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA64_RS24170	COG1228	amidohydrolase
ISA64_RS24180	COG1335	isochorismatase
ISA64_RS24185	COG0583	DNA-binding transcription factor activity
ISA64_RS24190	COG0366	Alpha amylase catalytic
ISA64_RS24215	COG0420	3'-5' exonuclease activity
ISA64_RS24220	COG0419	ATPase involved in DNA repair
ISA64_RS24225	COG1940	carbohydrate kinase activity
ISA64_RS24240	COG4126	flavin adenine dinucleotide binding
ISA64_RS24250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA64_RS24255	COG3416	Protein conserved in bacteria
ISA64_RS24265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISA64_RS24275	COG1785	Belongs to the alkaline phosphatase family
ISA64_RS24315	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ISA64_RS24320	COG1335	isochorismatase
ISA64_RS24325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISA64_RS24330	COG0113	porphobilinogen synthase activity
ISA64_RS24335	COG1943	Transposase
ISA64_RS24345	COG2175	clavaminate synthase activity
ISA64_RS24350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA64_RS24355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ISA64_RS24360	COG4521	taurine ABC transporter
ISA64_RS24365	COG2040	homocysteine
ISA64_RS24370	COG0833	amino acid
ISA64_RS24385	COG4303	Ethanolamine ammonia lyase large subunit
ISA64_RS24390	COG4302	ethanolamine ammonia-lyase activity
ISA64_RS24430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA64_RS24435	COG1126	abc transporter atp-binding protein
ISA64_RS24440	COG4597	amino acid ABC transporter
ISA64_RS24445	COG0765	amino acid transport
ISA64_RS24460	COG3188	usher protein
ISA64_RS24485	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISA64_RS24495	COG3639	organic phosphonate transmembrane transporter activity
ISA64_RS24515	COG0791	NLP P60 protein
ISA64_RS24550	COG3188	usher protein
ISA64_RS24555	COG3121	Chaperone
ISA64_RS24560	COG3539	Fimbrial protein
ISA64_RS24575	COG3710	Transcriptional regulator
ISA64_RS24605	COG2200	EAL domain
ISA64_RS24625	COG3121	Chaperone
ISA64_RS24630	COG3188	usher protein
ISA64_RS24650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISA64_RS24665	COG0579	oxidoreductase
ISA64_RS24670	COG1012	belongs to the aldehyde dehydrogenase family
ISA64_RS24675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA64_RS24680	COG1113	amino acid transport
ISA64_RS24685	COG1802	Transcriptional regulator
ISA64_RS24705	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISA64_RS24710	COG0454	-acetyltransferase
ISA64_RS24725	COG2991	Protein conserved in bacteria
ISA64_RS24740	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA64_RS24745	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA64_RS24760	COG3034	peptidoglycan biosynthetic process
ISA64_RS24765	COG0121	glutamine amidotransferase
ISA64_RS24775	COG1960	acyl-CoA dehydrogenase activity
ISA64_RS24780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA64_RS24790	COG0583	DNA-binding transcription factor activity
ISA64_RS24800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA64_RS24810	COG2226	methyltransferase
ISA64_RS24820	COG0741	lytic transglycosylase activity
ISA64_RS24820	COG1388	LysM domain
ISA64_RS24825	COG2226	methyltransferase
ISA64_RS24835	COG2814	Major facilitator Superfamily
ISA64_RS24840	COG0583	DNA-binding transcription factor activity
ISA64_RS24845	COG0656	L-ascorbic acid biosynthetic process
ISA64_RS24880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISA64_RS24890	COG2011	ABC-type metal ion transport system permease component
ISA64_RS24895	COG1464	Belongs to the NlpA lipoprotein family
ISA64_RS24905	COG1720	tRNA m6t6A37 methyltransferase activity
ISA64_RS24915	COG0791	NLP P60 protein
ISA64_RS24920	COG3015	lipoprotein NlpE involved in copper resistance
ISA64_RS24925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ISA64_RS24940	COG4568	rho-dependent transcription termination
ISA64_RS24950	COG0346	lactoylglutathione lyase activity
ISA64_RS24955	COG1982	Orn Lys Arg decarboxylase major
ISA64_RS24965	COG0587	DNA-directed DNA polymerase activity
ISA64_RS24995	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ISA64_RS25005	COG0750	zinc metalloprotease
ISA64_RS25010	COG0575	Belongs to the CDS family
ISA64_RS25020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISA64_RS25045	COG0024	Methionine aminopeptidase
ISA64_RS25050	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ISA64_RS25065	COG3835	regulator
ISA64_RS25070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA64_RS25090	COG2860	membrane
ISA64_RS25110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA64_RS25115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA64_RS25120	COG1120	ATPase activity
ISA64_RS25125	COG4774	siderophore transport
ISA64_RS25130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA64_RS25220	COG1643	Atp-dependent helicase
ISA64_RS25225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISA64_RS25245	COG0617	tRNA 3'-terminal CCA addition
ISA64_RS25250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISA64_RS25270	COG0726	polysaccharide deacetylase
ISA64_RS25275	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA64_RS25280	COG0842	Transport permease protein
ISA64_RS25285	COG1131	(ABC) transporter
ISA64_RS25290	COG0288	reversible hydration of carbon dioxide
ISA64_RS25305	COG4993	Dehydrogenase
ISA64_RS25310	COG2132	Multicopper oxidase
ISA64_RS25355	COG3064	Membrane
ISA64_RS25370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA64_RS25375	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA64_RS25380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISA64_RS25385	COG2186	Transcriptional regulator
ISA64_RS25390	COG1113	amino acid transport
ISA64_RS25395	COG2211	Major facilitator Superfamily
ISA64_RS25400	COG3940	Belongs to the glycosyl hydrolase 43 family
ISA64_RS25405	COG3725	Membrane protein required for beta-lactamase induction
ISA64_RS25410	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA64_RS25420	COG4969	Belongs to the N-Me-Phe pilin family
ISA64_RS25425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISA64_RS25430	COG1459	type II secretion system
ISA64_RS25520	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ISA64_RS25550	COG0697	spore germination
ISA64_RS25580	COG0840	transmembrane signaling receptor activity
ISA64_RS25620	COG0583	DNA-binding transcription factor activity
ISA64_RS25635	COG0024	Methionine aminopeptidase
ISA64_RS25645	COG2267	carboxylic ester hydrolase activity
ISA64_RS25650	COG0583	DNA-binding transcription factor activity
ISA64_RS25900	COG1475	DNA binding
ISA64_RS25970	COG5499	transcription regulator containing HTH domain