locus-tag class description HC645_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HC645_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HC645_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC645_RS00025 ENOG410667J hydrolase HC645_RS00040 ENOG4105EMF GntR family transcriptional regulator HC645_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HC645_RS00050 ENOG4108RTU Aldolase HC645_RS00055 ENOG4105CXK mandelate racemase muconate lactonizing HC645_RS00060 ENOG4105DJB Major Facilitator Superfamily HC645_RS00065 ENOG4105D99 atp gtp-binding protein HC645_RS00070 ENOG4105R2A (LipO)protein HC645_RS00090 ENOG4105D0C transport protein HC645_RS00095 ENOG4105FDP GntR family transcriptional regulator HC645_RS00100 ENOG4105CI1 PTS System HC645_RS00105 ENOG4105F8D glycoside hydrolase family 4 HC645_RS00110 ENOG4105VG5 Membrane HC645_RS00115 ENOG4105JP4 Inner membrane protein yidG HC645_RS00140 ENOG4105W8I Transcriptional regulator HC645_RS00145 ENOG4105E5M Multidrug resistance protein D HC645_RS00175 ENOG4105C7K acetolactate synthase HC645_RS00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit HC645_RS00185 ENOG4108KX4 response regulator HC645_RS00190 ENOG4105BZU Histidine kinase HC645_RS00195 ENOG4105CXY transporter HC645_RS00200 ENOG4105CXY transporter HC645_RS00210 ENOG4108SAJ Protein of unknown function (DUF1198) HC645_RS00235 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HC645_RS00240 ENOG4107STF Involved in phosphonate degradation (By similarity) HC645_RS00245 ENOG4106S9K Transcriptional regulator HC645_RS00260 ENOG4108MP3 ABC transporter, permease HC645_RS00270 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HC645_RS00275 ENOG4105VCP PTS System HC645_RS00280 ENOG4105CK1 PTS System HC645_RS00285 ENOG4105VZJ PTS System HC645_RS00290 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS00295 ENOG4105D2S major facilitator superfamily HC645_RS00305 ENOG4107F9Y LysR family transcriptional regulator HC645_RS00315 ENOG4105JSC dimethylmenaquinone methyltransferase HC645_RS00330 ENOG4105T8A Uncharacterized protein YicS HC645_RS00335 ENOG4108UZ3 Transporter HC645_RS00340 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HC645_RS00345 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HC645_RS00350 ENOG4105C2C drug resistance transporter, Bcr CflA HC645_RS00355 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HC645_RS00360 ENOG4105BZS acriflavin resistance protein HC645_RS00365 ENOG4105C1P efflux transporter, rnd family, mfp subunit HC645_RS00385 ENOG410630P Transcriptional regulator HC645_RS00395 ENOG4105CR8 Transcriptional regulator HC645_RS00420 ENOG4105D01 (LipO)protein HC645_RS00435 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HC645_RS00445 ENOG4105DQ4 alcohol dehydrogenase HC645_RS00465 ENOG4105NI3 Protein of unknown function (DUF3237) HC645_RS00475 ENOG4105CT4 transporter HC645_RS00480 ENOG4105CJQ hydrolase, family 31 HC645_RS00490 ENOG4105F8D glycoside hydrolase family 4 HC645_RS00495 ENOG4105CI1 PTS System HC645_RS00500 ENOG4105JV1 AsmA family HC645_RS00505 ENOG4105C2W permease HC645_RS00510 ENOG4105D6U Sodium Glutamate Symporter HC645_RS00515 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HC645_RS00520 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HC645_RS00525 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HC645_RS00530 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HC645_RS00545 ENOG4105CP7 Triose-phosphate isomerase HC645_RS00550 ENOG4105EBK exported protein HC645_RS00555 ENOG4108VTS Membrane HC645_RS00560 ENOG4105DP0 ferredoxin-NADP reductase HC645_RS00565 ENOG4105CBT Fructose-1,6-bisphosphatase HC645_RS00570 ENOG4105CB5 ATP-dependent DNA helicase recG HC645_RS00575 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HC645_RS00580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HC645_RS00590 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HC645_RS00600 ENOG4105EN6 Membrane HC645_RS00610 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HC645_RS00615 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) HC645_RS00695 ENOG4105XB7 anti-repressor protein HC645_RS00720 ENOG4105DSJ YicC domain protein HC645_RS00745 ENOG4105CJ1 ABC, transporter HC645_RS00750 ENOG4107QWP ABC-2 type transporter HC645_RS00755 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HC645_RS00765 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HC645_RS00770 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HC645_RS00775 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HC645_RS00780 ENOG4105W5Q DNA repair protein (RadC HC645_RS00785 ENOG4105KDC 50s ribosomal protein l28 HC645_RS00790 ENOG4105W0E 50S ribosomal protein L33 HC645_RS00795 ENOG4108M24 von Willebrand factor, type A HC645_RS00820 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HC645_RS00825 ENOG4106WTF Glycosyl transferase, family 2 HC645_RS00830 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HC645_RS00835 ENOG4105K64 Glycosyl transferase, family 2 HC645_RS00840 ENOG4105CPK Glycosyl transferase (Group 1 HC645_RS00850 ENOG4105DKP glycosyl transferase, family 9 HC645_RS00865 ENOG41068PG O-Antigen polymerase HC645_RS00870 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HC645_RS00875 ENOG4105D16 lipopolysaccharide heptosyltransferase i HC645_RS00880 ENOG4105XA0 heptosyltransferase ii HC645_RS00885 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HC645_RS00890 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HC645_RS00895 ENOG4105CPQ Dehydrogenase HC645_RS00900 ENOG4106WTF Glycosyl transferase, family 2 HC645_RS00905 ENOG4105PXI polysaccharide deacetylase HC645_RS00910 ENOG41063SB peptidase HC645_RS00920 ENOG4107YZP Rhodanese domain protein HC645_RS00925 ENOG4105VW4 glutaredoxin 3 HC645_RS00930 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HC645_RS00935 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HC645_RS00940 ENOG4105D7W serine acetyltransferase HC645_RS00945 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HC645_RS00950 ENOG4105DMF Dehydrogenase HC645_RS00955 ENOG41073TP transcriptional regulator HC645_RS00960 ENOG4105DAA L-lactate HC645_RS00965 ENOG4108YYI Protein of unknown function (DUF2810) HC645_RS00975 ENOG4105E61 Mannitol repressor protein HC645_RS00980 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HC645_RS00985 ENOG4105CTS PTS system mannitol-specific HC645_RS00990 ENOG4108U78 Glutathione S-transferase HC645_RS00995 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HC645_RS01000 ENOG4105EM7 Selenocysteine-specific translation elongation factor HC645_RS01005 ENOG4105J4Q Transcriptional regulator HC645_RS01010 ENOG4108RC0 Electron transport protein HC645_RS01015 ENOG4105JKW Valine--pyruvate aminotransferase HC645_RS01020 ENOG4107T9C Alpha amylase catalytic region HC645_RS01025 ENOG4108UR8 BAX protein HC645_RS01030 ENOG4105T16 Transcriptional regulator (AraC family) HC645_RS01035 ENOG4108HWW ABC transporter HC645_RS01045 ENOG4105DFW ABC transporter HC645_RS01050 ENOG4105C93 Xylose Isomerase HC645_RS01055 ENOG4105CMG Carbohydrate kinase HC645_RS01060 ENOG410688U Inner membrane protein yiaB HC645_RS01065 ENOG4108Z12 YiaAB two helix domain-containing protein HC645_RS01070 ENOG4105MEV Acyl-transferase HC645_RS01080 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HC645_RS01085 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HC645_RS01110 ENOG41060TC Hok gef cell toxic protein HC645_RS01125 ENOG4105MVF Transcriptional regulator HC645_RS01130 ENOG4105D2S major facilitator superfamily HC645_RS01135 ENOG4106JH6 (LipO)protein HC645_RS01140 ENOG4105C5I Dehydrogenase HC645_RS01150 ENOG4105D7K pfkb domain protein HC645_RS01160 ENOG4108M60 Transcriptional regulator HC645_RS01170 ENOG4108ZG0 Ompa motb domain protein HC645_RS01175 ENOG4107QY8 reductase HC645_RS01180 ENOG4105HNP -acetyltransferase HC645_RS01185 ENOG4108R3E Dna-3-methyladenine glycosylase i HC645_RS01190 ENOG4105EAX Putative lipase HC645_RS01195 ENOG4105FCD Major Facilitator HC645_RS01200 ENOG4105DIJ Phosphoethanolamine transferase HC645_RS01220 ENOG4105DEF Extracellular solute-binding protein, family 5 HC645_RS01225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC645_RS01230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS01235 ENOG4105C3U ABC transporter HC645_RS01240 ENOG4108JQ7 (ABC) transporter HC645_RS01255 ENOG4107U53 septum site-determining protein minD HC645_RS01260 ENOG4107QZ7 Cellulose synthase catalytic subunit HC645_RS01265 ENOG4107EEX Cellulose synthase regulator protein HC645_RS01270 ENOG4105EJG cellulose synthase HC645_RS01285 ENOG4105D1V cellulose synthase operon protein YhjU HC645_RS01290 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HC645_RS01295 ENOG4105U74 cellulose biosynthesis protein BcsE HC645_RS01300 ENOG410661M cytoplasmic protein HC645_RS01305 ENOG4105UTS cellulose synthase operon protein YhjQ HC645_RS01310 ENOG4107QZ7 Cellulose synthase catalytic subunit HC645_RS01315 ENOG4107EEX Cellulose synthase regulator protein HC645_RS01320 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HC645_RS01325 ENOG4105EJG cellulose synthase HC645_RS01330 ENOG4105BZU Histidine kinase HC645_RS01335 ENOG4105CK2 sodium dicarboxylate symporter HC645_RS01340 ENOG4105CS0 peptidase HC645_RS01355 ENOG41066T0 asmA family HC645_RS01360 ENOG4105CSH Transporter HC645_RS01365 ENOG4107H3J ribonuclease HC645_RS01370 ENOG4105CBN LysR family transcriptional regulator HC645_RS01375 ENOG4105CHR reductase HC645_RS01390 ENOG4105C0A alcohol dehydrogenase HC645_RS01400 ENOG4105DC8 reductase HC645_RS01405 ENOG4105D6S protein involved in catabolism of external DNA HC645_RS01410 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HC645_RS01415 ENOG4105DGW oligopeptidase A HC645_RS01420 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HC645_RS01425 ENOG4105DUX Transporter HC645_RS01435 ENOG4108V6B universal stress protein B HC645_RS01440 ENOG4105CJ3 phosphate transporter HC645_RS01445 ENOG4105CBX hi0933 family HC645_RS01450 ENOG4105CJW magnesium transporter HC645_RS01460 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HC645_RS01470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS01475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC645_RS01480 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HC645_RS01490 ENOG4105PY6 Phenolic acid decarboxylase HC645_RS01495 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HC645_RS01500 ENOG4105CKK Glycosyl transferase, family 2 HC645_RS01505 ENOG4105C3I Nad-dependent epimerase dehydratase HC645_RS01510 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HC645_RS01515 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HC645_RS01520 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HC645_RS01525 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HC645_RS01530 ENOG4105DSF transport protein HC645_RS01535 ENOG4105F9N Major Facilitator Superfamily HC645_RS01540 ENOG4108W1V Lipoprotein HC645_RS01545 ENOG4105EX9 Membrane HC645_RS01550 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HC645_RS01560 ENOG4107FS9 Membrane HC645_RS01570 ENOG4105MG3 Membrane HC645_RS01575 ENOG4106H78 methyltransferase HC645_RS01580 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HC645_RS01585 ENOG4105CAK Cell division ATP-binding protein ftsE HC645_RS01590 ENOG4105CRP Part of the ABC transporter FtsEX involved in HC645_RS01605 ENOG4108JPW Aminotransferase HC645_RS01615 ENOG4105CP9 extracellular ligand-binding receptor HC645_RS01620 ENOG4105U59 -acetyltransferase HC645_RS01625 ENOG4105CP9 extracellular ligand-binding receptor HC645_RS01630 ENOG4105C32 Amino acid ABC transporter (Permease) HC645_RS01635 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HC645_RS01640 ENOG4105C0Z ABC transporter HC645_RS01645 ENOG4108IV0 ABC, transporter HC645_RS01650 ENOG41060M8 Pfam:PhdYeFM HC645_RS01660 ENOG4105BZ7 extracellular solute-binding protein family 1 HC645_RS01665 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HC645_RS01680 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HC645_RS01685 ENOG4105WC8 Conserved Protein HC645_RS01690 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HC645_RS01695 ENOG4105WCN acetyltransferase HC645_RS01705 ENOG4105D9R oxidoreductase HC645_RS01710 ENOG4105C2I pirin domain protein HC645_RS01715 ENOG4105DIQ Transcriptional regulator HC645_RS01720 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HC645_RS01725 ENOG4105C6Z Gluconate HC645_RS01735 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HC645_RS01740 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HC645_RS01745 ENOG4108IUM Glycogen debranching enzyme HC645_RS01750 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HC645_RS01755 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HC645_RS01760 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HC645_RS01775 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HC645_RS01780 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HC645_RS01785 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HC645_RS01790 ENOG4105E98 transcriptional regulator DeoR family HC645_RS01795 ENOG41061ZR Transcriptional regulator HC645_RS01800 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HC645_RS01805 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HC645_RS01810 ENOG4105C6Z Gluconate HC645_RS01815 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HC645_RS01820 ENOG4105MJ2 Competence protein HC645_RS01825 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HC645_RS01835 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HC645_RS01840 ENOG4105CE1 Ferrous iron transport protein b HC645_RS01845 ENOG4105XFK Ferrous iron transport protein A HC645_RS01850 ENOG4105BZM domain protein HC645_RS01855 ENOG4108RRZ Transcription elongation factor GreB HC645_RS01865 ENOG4105E0F Histidine kinase HC645_RS01880 ENOG4105VEJ Heat shock protein HC645_RS01885 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HC645_RS01890 ENOG4105DQY intracellular growth attenuator HC645_RS01895 ENOG4107RK2 ADP-ribose diphosphatase NudE HC645_RS01900 ENOG4108JQC penicillin-binding protein 1A HC645_RS01925 ENOG4105E4G Type IV pilus HC645_RS01930 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HC645_RS01935 ENOG4105D49 3-dehydroquinate synthase HC645_RS01940 ENOG4105EGB membrane protein DamX HC645_RS01945 ENOG4105DFE Dna adenine methylase HC645_RS01950 ENOG4105DJV ribulose-phosphate 3-epimerase HC645_RS01960 ENOG4105C31 Tryptophanyl-tRNA synthetase HC645_RS01965 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HC645_RS01970 ENOG4105WZK nitrite reductase NADPH small subunit HC645_RS01975 ENOG4107QZF nitrite reductase NADPH large subunit HC645_RS01985 ENOG4105DZC cytosine deaminase HC645_RS01990 ENOG4106DTQ Protein TsgA homolog HC645_RS01995 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HC645_RS02000 ENOG4106195 uncharacterized protein yhfG HC645_RS02005 ENOG4105MZU cell filamentation protein HC645_RS02015 ENOG4105C8Y Acetylornithine aminotransferase HC645_RS02020 ENOG410613R integral membrane protein, YccS YhfK family HC645_RS02025 ENOG4107RYR Transcriptional regulator, Crp Fnr family HC645_RS02030 ENOG4108UKZ OsmC family HC645_RS02035 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HC645_RS02040 ENOG4105YP7 UPF0270 protein HC645_RS02045 ENOG4105DNZ Alpha Beta Hydrolase HC645_RS02055 ENOG4105C5H ABC transporter HC645_RS02060 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HC645_RS02065 ENOG4105CKD glutathione-regulated potassium-efflux system protein HC645_RS02070 ENOG4105VKU nucleicacid-binding protein HC645_RS02075 ENOG4108YZY peptidylprolyl cis-trans isomerase HC645_RS02080 ENOG4105VRX Protein slyX homolog HC645_RS02085 ENOG4108V1T peptidylprolyl cis-trans isomerase HC645_RS02090 ENOG4105WWK YheO domain protein HC645_RS02095 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HC645_RS02100 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HC645_RS02105 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HC645_RS02110 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HC645_RS02115 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HC645_RS02120 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HC645_RS02125 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HC645_RS02130 ENOG4105W53 bacterioferritin-associated ferredoxin HC645_RS02135 ENOG4108UQY Iron-storage protein HC645_RS02150 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HC645_RS02155 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HC645_RS02165 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HC645_RS02170 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HC645_RS02175 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HC645_RS02180 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HC645_RS02185 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HC645_RS02190 ENOG41083MP 50s ribosomal protein l29 HC645_RS02195 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HC645_RS02200 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HC645_RS02205 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HC645_RS02220 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HC645_RS02225 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HC645_RS02235 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HC645_RS02240 ENOG4105VPB 50S ribosomal protein L30 HC645_RS02245 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HC645_RS02250 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HC645_RS02255 ENOG41067V7 50S ribosomal protein L36 HC645_RS02260 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HC645_RS02265 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HC645_RS02270 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HC645_RS02275 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC645_RS02280 ENOG4108ZT0 50S ribosomal protein l17 HC645_RS02285 ENOG4105VTS DnaJ-like, subfamily C HC645_RS02290 ENOG4105W1Y Transcriptional regulator HC645_RS02295 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HC645_RS02300 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HC645_RS02305 ENOG4105C1A potassium transporter peripheral membrane HC645_RS02310 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HC645_RS02315 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HC645_RS02320 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HC645_RS02325 ENOG4105C79 DNA protecting protein DprA HC645_RS02335 ENOG4108WI1 Dna topoisomerase HC645_RS02340 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HC645_RS02345 ENOG4105E2X shikimate dehydrogenase HC645_RS02350 ENOG4105SG3 Protein of unknown function (DUF1488) HC645_RS02355 ENOG4108Z0R Transferase HC645_RS02385 ENOG4105XCM membrane LIPOPROTEIN HC645_RS02390 ENOG4105BZS acriflavin resistance protein HC645_RS02395 ENOG4105C1P efflux transporter, rnd family, mfp subunit HC645_RS02400 ENOG4108XG4 DNA-binding transcriptional regulator HC645_RS02410 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HC645_RS02415 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HC645_RS02420 ENOG4108IA2 Sodium pantothenate symporter HC645_RS02425 ENOG4105RG0 Membrane HC645_RS02430 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HC645_RS02435 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HC645_RS02445 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HC645_RS02460 ENOG41062P1 Diguanylate cyclase phosphodiesterase HC645_RS02470 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HC645_RS02475 ENOG4105VQ7 Rod shape-determining protein MreD HC645_RS02480 ENOG4108Z03 MAF-like protein HC645_RS02485 ENOG4105C03 ribonuclease HC645_RS02490 ENOG4105QD6 exported protein HC645_RS02495 ENOG4105D1U peptidase U62 modulator of DNA gyrase HC645_RS02500 ENOG4105CR8 Transcriptional regulator HC645_RS02515 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HC645_RS02520 ENOG4105UNR (Barnase) inhibitor HC645_RS02525 ENOG4105RID UPF0379 protein yhcN HC645_RS02530 ENOG4105RID UPF0379 protein yhcN HC645_RS02535 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HC645_RS02540 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HC645_RS02545 ENOG4105C0H protease HC645_RS02550 ENOG4105C0H protease HC645_RS02555 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HC645_RS02560 ENOG4105D6Z AFG1 family ATPase HC645_RS02565 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HC645_RS02580 ENOG4107MKT Stringent starvation protein a HC645_RS02585 ENOG4105KB2 stringent starvation protein b HC645_RS02590 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HC645_RS02595 ENOG4105BZ8 glutamate synthase HC645_RS02600 ENOG4105CBC glutamate synthase HC645_RS02605 ENOG4105N5T Radical SAM Protein HC645_RS02610 ENOG4108I5G Major Facilitator superfamily HC645_RS02615 ENOG4105CPQ Dehydrogenase HC645_RS02625 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HC645_RS02630 ENOG4105BZU Histidine kinase HC645_RS02635 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HC645_RS02645 ENOG41080Z8 PHOSPHOCARRIER protein HC645_RS02650 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HC645_RS02655 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HC645_RS02660 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HC645_RS02665 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC645_RS02670 ENOG4108IUZ ABC transporter HC645_RS02675 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HC645_RS02680 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HC645_RS02685 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HC645_RS02690 ENOG4105C2X Arabinose 5-phosphate isomerase HC645_RS02695 ENOG4105FEU K -dependent Na -Ca exchanger HC645_RS02700 ENOG4105DHJ ABC, transporter HC645_RS02705 ENOG4105CY3 ABC transporter, permease HC645_RS02710 ENOG4107PE3 Mammalian cell entry related domain protein HC645_RS02715 ENOG4105E3I toluene tolerance HC645_RS02720 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HC645_RS02725 ENOG4105VFK BolA family HC645_RS02730 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HC645_RS02735 ENOG4105HVQ Regulatory factor of maltose metabolism HC645_RS02740 ENOG4105EAH synthase HC645_RS02745 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HC645_RS02750 ENOG4105K46 50S ribosomal protein l27 HC645_RS02755 ENOG4105QYV Membrane HC645_RS02760 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HC645_RS02765 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HC645_RS02770 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HC645_RS02775 ENOG4105HBR Rna-binding protein HC645_RS02780 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HC645_RS02785 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HC645_RS02790 ENOG4105EEI dihydropteroate synthase HC645_RS02795 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HC645_RS02800 ENOG4105NTZ Preprotein translocase subunit SecG HC645_RS02815 ENOG4108UII YfaZ family HC645_RS02820 ENOG4108PNB DNA-binding transcriptional regulator HC645_RS02825 ENOG4105CDH Citrulline--aspartate ligase HC645_RS02840 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HC645_RS02845 ENOG4105CHV Transcription elongation factor NusA HC645_RS02850 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HC645_RS02855 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HC645_RS02860 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HC645_RS02865 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HC645_RS02870 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HC645_RS02885 ENOG4105C1J atp-dependent rna helicase HC645_RS02890 ENOG4105CIC tryptophan-specific transport protein HC645_RS02895 ENOG4105DEN Luciferase family HC645_RS02915 ENOG4108YYD acetyltransferase HC645_RS02920 ENOG41082IR Excinuclease ABC C subunit domain protein HC645_RS02925 ENOG4108ZPB UPF0306 protein HC645_RS02930 ENOG4107R7Y intracellular protease Pfpi family HC645_RS02935 ENOG4105K4T epimerase HC645_RS02940 ENOG4107S21 permease HC645_RS02945 ENOG4105W4M Transport-associated protein HC645_RS02950 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HC645_RS02955 ENOG41082RQ UPF0102 protein HC645_RS02960 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HC645_RS02965 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HC645_RS02970 ENOG4105CTX dehydratase HC645_RS02980 ENOG4105DJB Major Facilitator Superfamily HC645_RS02985 ENOG4105CNV Aldolase HC645_RS02990 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HC645_RS02995 ENOG4105BZW Glycerate kinase HC645_RS03020 ENOG4106D80 Uncharacterized protein YhaL HC645_RS03025 ENOG4108CNN domain protein HC645_RS03030 ENOG4105CWB LysR family transcriptional Regulator HC645_RS03035 ENOG4105KAF membrAne HC645_RS03040 ENOG4105CHF Glutathione S-transferase HC645_RS03045 ENOG4108VBZ doxx family HC645_RS03050 ENOG4105YJD HC645_RS03055 ENOG41090KG Inner membrane protein YqjE HC645_RS03060 ENOG4105NE1 Conserved Protein HC645_RS03065 ENOG4105WAY exported protein HC645_RS03070 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HC645_RS03075 ENOG4106W5V Membrane HC645_RS03080 ENOG4107YCY Transcriptional regulator HC645_RS03085 ENOG4105DPW Major facilitator superfamily MFS_1 HC645_RS03095 ENOG4105CTX dehydratase HC645_RS03100 ENOG4105P66 Membrane HC645_RS03105 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HC645_RS03110 ENOG4105DU1 integral membrane protein, terc HC645_RS03115 ENOG4105EE0 oxidoreductase HC645_RS03120 ENOG4108VKG metal-dependent hydrolase HC645_RS03140 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HC645_RS03145 ENOG4107RYS Autoinducer-2 (AI-2) kinase HC645_RS03150 ENOG4105DKT Transcriptional regulator HC645_RS03155 ENOG4105C2J ABC transporter HC645_RS03160 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HC645_RS03165 ENOG4105F5R ABC transporter HC645_RS03170 ENOG4105D4B ABC, transporter HC645_RS03175 ENOG41061GT Aldolase HC645_RS03180 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HC645_RS03185 ENOG4105C8Y Acetylornithine aminotransferase HC645_RS03190 ENOG4105NTW Transcriptional regulator HC645_RS03200 ENOG4105Q26 Siderophore-interacting protein HC645_RS03215 ENOG4108UTZ Dihydroxyacetone kinase HC645_RS03220 ENOG4105CMT Dihydroxyacetone kinase HC645_RS03250 ENOG4105C0A alcohol dehydrogenase HC645_RS03265 ENOG4105YCI dehydratase medium subunit HC645_RS03270 ENOG4108ZFT Dehydratase small subunit HC645_RS03275 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HC645_RS03280 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HC645_RS03285 ENOG4105XXV Acid-resistance protein HC645_RS03290 ENOG4108YK4 Acid-resistance membrane protein HC645_RS03295 ENOG4108V08 YfdX protein HC645_RS03300 ENOG4105BZU Histidine kinase HC645_RS03305 ENOG4108WQH regulatoR HC645_RS03325 ENOG4108VCA G U mismatch-specific DNA glycosylase HC645_RS03330 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC645_RS03335 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HC645_RS03345 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HC645_RS03355 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HC645_RS03365 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HC645_RS03370 ENOG4105CQM Urea amidohydrolase subunit alpha HC645_RS03375 ENOG4105KI2 Urea amidohydrolase subunit beta HC645_RS03380 ENOG4108YZ9 Urea amidohydrolase subunit gamma HC645_RS03385 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HC645_RS03400 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HC645_RS03405 ENOG4107ZVW dihydroneopterin aldolase HC645_RS03410 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HC645_RS03415 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HC645_RS03420 ENOG4106MWK domain protein HC645_RS03425 ENOG4105I7R Adenylate cyclase HC645_RS03430 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HC645_RS03435 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HC645_RS03450 ENOG4105W0Z cytoplasmic protein HC645_RS03455 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HC645_RS03465 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HC645_RS03470 ENOG4106032 Glutathionylspermidine synthase HC645_RS03475 ENOG4105F1G UPF0441 protein HC645_RS03485 ENOG41087AY ADP-Ribose pyrophosphatase HC645_RS03490 ENOG4108SX3 cytoplasmic protein HC645_RS03495 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HC645_RS03500 ENOG4105IPS esterase HC645_RS03505 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC645_RS03510 ENOG4105VRH Antibiotic biosynthesis monooxygenase HC645_RS03515 ENOG4105NF4 modulator of drug activity HC645_RS03520 ENOG4105DHQ Histidine kinase HC645_RS03525 ENOG4105XJC Two component transcriptional regulator (Winged helix family HC645_RS03530 ENOG4105H4F exported protein HC645_RS03535 ENOG4105F4I Transcriptional regulator HC645_RS03540 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC645_RS03545 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HC645_RS03550 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HC645_RS03555 ENOG4105CCT upf0313 protein HC645_RS03565 ENOG4105CV8 reductase HC645_RS03570 ENOG4108I6A alcohol dehydrogenase HC645_RS03575 ENOG4105CF7 AraC family transcriptional regulator HC645_RS03580 ENOG4108K81 inner membrane protein YghB HC645_RS03585 ENOG4105C28 cystathionine HC645_RS03595 ENOG4105CWK Biopolymer transport protein, ExbB HC645_RS03600 ENOG4108ZZF transport protein (ExbD) HC645_RS03605 ENOG4105CT4 transporter HC645_RS03610 ENOG4105E4I Glycoside hydrolase family 28 HC645_RS03615 ENOG4108TEB UPF0114 protein HC645_RS03625 ENOG410900S Protein of unknown function (DUF2623) HC645_RS03630 ENOG4105CYM Glutathione S-transferase HC645_RS03645 ENOG4106032 Glutathionylspermidine synthase HC645_RS03650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC645_RS03670 ENOG4105CC0 LysR family Transcriptional regulator HC645_RS03675 ENOG4105C28 cystathionine HC645_RS03690 ENOG4108UQV Membrane HC645_RS03695 ENOG4105CXN decarboxylase HC645_RS03700 ENOG4105EAA nucleoside HC645_RS03705 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HC645_RS03710 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HC645_RS03715 ENOG4105CEN a g-specific adenine glycosylase HC645_RS03720 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HC645_RS03725 ENOG41090ED Protein with unknown function (DUF469) HC645_RS03730 ENOG4105K33 Periplasmic Protein HC645_RS03735 ENOG4108HWW ABC transporter HC645_RS03740 ENOG4105C2J ABC transporter HC645_RS03750 ENOG4105CSA Coproporphyrinogen iii oxidase HC645_RS03755 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HC645_RS03760 ENOG4105VZ9 UPF0235 protein HC645_RS03765 ENOG4108VIA integral membrane protein HC645_RS03770 ENOG4105DFA alanine racemase domain protein HC645_RS03775 ENOG4105CZX twitching motility protein HC645_RS03785 ENOG41086KC Transcriptional regulator HC645_RS03790 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HC645_RS03795 ENOG4108UJU UPF0301 protein HC645_RS03800 ENOG4105D7Z glutathione synthase HC645_RS03805 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HC645_RS03810 ENOG4105RWS endonuclease I HC645_RS03815 ENOG4105GPY SprT protein HC645_RS03820 ENOG4107QNK )-transporter HC645_RS03825 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HC645_RS03845 ENOG4105CYW agmatinase HC645_RS03850 ENOG41090KI Outer membrane porin HC645_RS03860 ENOG4108K0D peptidase, M48 HC645_RS03865 ENOG4105CV1 Transketolase (EC 2.2.1.1) HC645_RS03870 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HC645_RS03880 ENOG4105D2N Aldolase HC645_RS03885 ENOG4105D64 Mechanosensitive ion channel HC645_RS03890 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HC645_RS03895 ENOG4105MPN Membrane HC645_RS03900 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HC645_RS03905 ENOG4105E66 phosphoriboisomerase A HC645_RS03915 ENOG4108JQ1 Dehydrogenase HC645_RS03920 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HC645_RS03930 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HC645_RS03935 ENOG4105E07 UPF0149 protein HC645_RS03940 ENOG4107RAQ aminopeptidase HC645_RS03945 ENOG4105D0A hydroxylase HC645_RS03950 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HC645_RS03955 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HC645_RS03960 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HC645_RS03965 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HC645_RS03970 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC645_RS03975 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC645_RS03995 ENOG4105CS2 ec 3.2.1.21 HC645_RS04000 ENOG4108Q3X Transcriptional regulator HC645_RS04005 ENOG4105N5Z UPF0267 protein HC645_RS04010 ENOG4108UT2 hemolysin iii HC645_RS04020 ENOG4105Y75 tpr repeat protein HC645_RS04025 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HC645_RS04030 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HC645_RS04035 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HC645_RS04040 ENOG4105T95 Thiol disulfide interChange protein HC645_RS04045 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HC645_RS04055 ENOG4105CRK lysyL-tRNA synthetase HC645_RS04060 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HC645_RS04070 ENOG4108K5P (LipO)protein HC645_RS04080 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC645_RS04095 ENOG4105CPC Aldo Keto reductase HC645_RS04110 ENOG4105W7K Transcriptional regulator HC645_RS04135 ENOG4107R5R arsenical pump membrane protein HC645_RS04140 ENOG4105K89 arsenate reductase HC645_RS04145 ENOG4105DUX Transporter HC645_RS04150 ENOG4105V2F Uncharacterized protein yoac HC645_RS04155 ENOG4105ETP RND efflux system, outer membrane lipoprotein HC645_RS04160 ENOG4108MI0 Resistance protein HC645_RS04165 ENOG4105J12 Multidrug resistance protein mdtN HC645_RS04175 ENOG4105VR1 Pfam:DUF1271 HC645_RS04180 ENOG410830R acetyltransferase HC645_RS04190 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HC645_RS04195 ENOG4108T65 Fimbrial HC645_RS04200 ENOG4108SQA Fimbrial HC645_RS04205 ENOG4105CW0 outer membrane usher protein HC645_RS04210 ENOG4108NAE Fimbrial chaperone protein HC645_RS04215 ENOG4108S54 Fimbrial protein HC645_RS04220 ENOG4108RQP Major type 1 subunit fimbrin HC645_RS04230 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HC645_RS04235 ENOG4108W9T type 1 fimbriae regulatory protein HC645_RS04240 ENOG4105D7X high-affinity nickel-transporter HC645_RS04245 ENOG4108ZT1 Transcriptional regulator HC645_RS04250 ENOG4108KTG Membrane protein, drug metabolite transporter HC645_RS04260 ENOG4108T1W Fimbrial subunit type 3 HC645_RS04300 ENOG4107S5I aldo keto reductase HC645_RS04305 ENOG4108MHD transport protein HC645_RS04315 ENOG4105C5Q Transcriptional regulator HC645_RS04320 ENOG4105CHU acetyl-coa acetyltransferase HC645_RS04325 ENOG4108QGT oligogalacturonate-specific porin HC645_RS04330 ENOG4105CAZ oligogalacturonide lyase HC645_RS04340 ENOG4105CHR reductase HC645_RS04345 ENOG4107QNK )-transporter HC645_RS04350 ENOG4106NDP Transcriptional regulator HC645_RS04360 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HC645_RS04365 ENOG4108HKT sucrose-6-phosphate hydrolase HC645_RS04380 ENOG4108IJ9 (ABC) transporter HC645_RS04385 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HC645_RS04390 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HC645_RS04395 ENOG4105YKW HC645_RS04405 ENOG4105RQF LysR family Transcriptional regulator HC645_RS04415 ENOG4105DDV Transcriptional regulator (LacI family HC645_RS04420 ENOG4105CK1 PTS System HC645_RS04425 ENOG4105CS2 ec 3.2.1.21 HC645_RS04430 ENOG4105C6F GntR Family Transcriptional Regulator HC645_RS04440 ENOG41060NJ transcriptional regulator HC645_RS04445 ENOG4105CEY Amp-dependent synthetase and ligase HC645_RS04450 ENOG4107S74 Lysophospholipid transporter LplT HC645_RS04455 ENOG4105CPC Aldo Keto reductase HC645_RS04460 ENOG4105SUV lipoprotein YgdR HC645_RS04465 ENOG4105EE5 Membrane protein terC HC645_RS04470 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HC645_RS04480 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HC645_RS04485 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HC645_RS04490 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HC645_RS04495 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HC645_RS04500 ENOG4105IPU prepilin peptidase dependent protein A HC645_RS04505 ENOG4105JCS prepilin peptidase dependent protein HC645_RS04510 ENOG4105SEN Protein of unknown function (DUF2509) HC645_RS04515 ENOG4105RVB Prepilin peptidase dependent protein c HC645_RS04520 ENOG4105DSY exodeoxyribonuclease V, gamma HC645_RS04525 ENOG4107QXK peptidase HC645_RS04535 ENOG4107QYX exodeoxyribonuclease v alpha HC645_RS04545 ENOG4107QZM n-acetylglutamate synthase HC645_RS04550 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC645_RS04555 ENOG4107QZB decarboxylase HC645_RS04560 ENOG4105JZC GHMP kinase HC645_RS04565 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HC645_RS04570 ENOG4105KTW ethanolamine utilization protein HC645_RS04575 ENOG4105M3W utilization protein HC645_RS04585 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HC645_RS04590 ENOG4105C0A alcohol dehydrogenase HC645_RS04595 ENOG4108EKI Dehydrogenase HC645_RS04605 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HC645_RS04620 ENOG4105KNY Microcompartments protein HC645_RS04625 ENOG4105KNY Microcompartments protein HC645_RS04635 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HC645_RS04640 ENOG4108ZFT Dehydratase small subunit HC645_RS04645 ENOG4105YCI dehydratase medium subunit HC645_RS04650 ENOG4105DMB glycerol dehydratase HC645_RS04655 ENOG4105EHR propanediol utilization protein pduB HC645_RS04660 ENOG4105KNY Microcompartments protein HC645_RS04665 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HC645_RS04670 ENOG4107XVH Transcriptional regulator HC645_RS04675 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HC645_RS04680 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HC645_RS04685 ENOG41081F0 Precorrin-8x methylmutase HC645_RS04690 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HC645_RS04695 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HC645_RS04700 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HC645_RS04705 ENOG4105CIA precorrin-4 C(11)-methyltransferase HC645_RS04710 ENOG4108P62 biosynthesis protein (CbiG) HC645_RS04715 ENOG4105E4R Precorrin-3B C17-methyltransferase HC645_RS04720 ENOG4105QUC reductase HC645_RS04725 ENOG4107PPM cobalt chelatase HC645_RS04730 ENOG4105DVK Precorrin-2 c20-methyltransferase HC645_RS04735 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HC645_RS04740 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HC645_RS04745 ENOG4108V4M Cobalt abc transporter HC645_RS04755 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HC645_RS04760 ENOG4108YZT Adenosylcobinamide kinase HC645_RS04765 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HC645_RS04785 ENOG4105CA3 membrane-bound lytic murein transglycosylase HC645_RS04790 ENOG4105CUZ uba thif-type nad fad binding protein HC645_RS04795 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HC645_RS04800 ENOG4105C9B Cysteine desulfurase HC645_RS04805 ENOG4105M5B (LipO)protein HC645_RS04810 ENOG4105ETT transcriptional Regulator, LysR family HC645_RS04815 ENOG4105M08 Membrane HC645_RS04825 ENOG4107EDW L-fucose operon activator HC645_RS04830 ENOG4105NWF RbsD or FucU transport HC645_RS04835 ENOG4105CMG Carbohydrate kinase HC645_RS04845 ENOG4105EDR glucose galactose transporter HC645_RS04855 ENOG4107W7X Aldolase HC645_RS04860 ENOG4105C0A alcohol dehydrogenase HC645_RS04865 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HC645_RS04870 ENOG4108JU7 Transcriptional regulator HC645_RS04880 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HC645_RS04895 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HC645_RS04900 ENOG4108UMI ABC transporter, permease HC645_RS04905 ENOG4105D01 (LipO)protein HC645_RS04910 ENOG41079KZ Major Facilitator Superfamily HC645_RS04920 ENOG4105GVF (ABC) transporter HC645_RS04925 ENOG4105EJQ L-serine dehydratase HC645_RS04930 ENOG4105C44 Serine transporter HC645_RS04935 ENOG4105EWT decarboxylase family HC645_RS04940 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HC645_RS04945 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HC645_RS04950 ENOG4105WP7 tRNA pseudouridine synthase C HC645_RS04955 ENOG4105DR9 pseudouridine synthase HC645_RS04960 ENOG4105QDK Flavodoxin HC645_RS04965 ENOG4105DJB Major Facilitator Superfamily HC645_RS04970 ENOG4105EQX glucarate dehydratase HC645_RS04975 ENOG4105EQX glucarate dehydratase HC645_RS04980 ENOG4105BZW Glycerate kinase HC645_RS04985 ENOG4105BZU Histidine kinase HC645_RS04990 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HC645_RS04995 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HC645_RS05000 ENOG4105DXN mazG family HC645_RS05005 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HC645_RS05010 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HC645_RS05025 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HC645_RS05030 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HC645_RS05035 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HC645_RS05040 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HC645_RS05045 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HC645_RS05050 ENOG4108MXK alkaline phosphatase isozyme conversion HC645_RS05055 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HC645_RS05060 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HC645_RS05070 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HC645_RS05075 ENOG4105N0Z inner membrane protein ygbE HC645_RS05080 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HC645_RS05085 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HC645_RS05090 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HC645_RS05095 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HC645_RS05105 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HC645_RS05110 ENOG4108K5P (LipO)protein HC645_RS05115 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC645_RS05140 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HC645_RS05145 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HC645_RS05150 ENOG4105KZM cytoplasmic protein HC645_RS05160 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HC645_RS05180 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HC645_RS05185 ENOG4105EHG Permease protein HC645_RS05190 ENOG4107R4I Periplasmic binding protein HC645_RS05195 ENOG4106QJH hemin transport protein HC645_RS05215 ENOG4108N2Y auxin Efflux HC645_RS05225 ENOG4105VXR cytoplasmic protein HC645_RS05230 ENOG4105CC5 ABC transporter HC645_RS05235 ENOG4105CC5 ABC transporter HC645_RS05240 ENOG4105DIK (ABC) transporter HC645_RS05250 ENOG4105DDV Transcriptional regulator (LacI family HC645_RS05255 ENOG4105DKQ ROK family HC645_RS05260 ENOG4105VCP PTS System HC645_RS05265 ENOG4105CK1 PTS System HC645_RS05270 ENOG4105VZJ PTS System HC645_RS05275 ENOG4105CK1 PTS System HC645_RS05280 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HC645_RS05290 ENOG4105CS2 ec 3.2.1.21 HC645_RS05300 ENOG4105C45 hydrogenase expression formation protein (HypE) HC645_RS05305 ENOG4105CQS hydrogenase expression formation protein HypD HC645_RS05310 ENOG41083WG hydrogenase assembly chaperone HC645_RS05315 ENOG4107RSS Hydrogenase accessory protein HypB HC645_RS05320 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HC645_RS05325 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HC645_RS05330 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HC645_RS05335 ENOG4107R30 NADH dehydrogenase HC645_RS05340 ENOG4107TDF Formate hydrogenlyase subunit 4 HC645_RS05345 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HC645_RS05350 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HC645_RS05355 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HC645_RS05360 ENOG4105I6X formate hydrogenlyase maturation HC645_RS05365 ENOG4108MG9 hydrogenase 3 maturation protease HC645_RS05375 ENOG4105CS2 ec 3.2.1.21 HC645_RS05380 ENOG4105C5Y PTS System HC645_RS05390 ENOG4105DDV Transcriptional regulator (LacI family HC645_RS05395 ENOG4108RC0 Electron transport protein HC645_RS05400 ENOG4105C8H hydrogenase maturation protein Hypf HC645_RS05410 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HC645_RS05415 ENOG4105CNW domain protein HC645_RS05425 ENOG4108JUA Transcriptional regulator HC645_RS05435 ENOG410804X Transcriptional regulator HC645_RS05440 ENOG4105J92 DNA-binding transcriptional activator GutM HC645_RS05445 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HC645_RS05450 ENOG4105VI0 Pts system, glucitol sorbitol-specific HC645_RS05455 ENOG4105DZY Pts system, glucitol sorbitol-specific HC645_RS05460 ENOG410787A Pts system, glucitol sorbitol-specific HC645_RS05465 ENOG4105CVE Lytic murein transglycosylase HC645_RS05475 ENOG4105CC5 ABC transporter HC645_RS05485 ENOG4107TH8 cina domain protein HC645_RS05490 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HC645_RS05495 ENOG4105Y3E Modulates RecA activity (By similarity) HC645_RS05500 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HC645_RS05505 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HC645_RS05535 ENOG4105K3G Periplasmic Protein HC645_RS05540 ENOG4107VXZ Hydrolase HC645_RS05545 ENOG4105W39 Membrane HC645_RS05550 ENOG4105D9M gamma-glutamylcysteine synthetase HC645_RS05565 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HC645_RS05570 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC645_RS05575 ENOG4105CW7 secretion protein, HlyD family HC645_RS05585 ENOG4105NTK Transcriptional repressor Mpra HC645_RS05595 ENOG4105ZED uncharacterized protein ygaH HC645_RS05600 ENOG4108UMN azlc family HC645_RS05605 ENOG4105GIJ Glycine betaine HC645_RS05610 ENOG4108HQS Glycine betaine HC645_RS05615 ENOG4108IJ7 Glycine betaine HC645_RS05620 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC645_RS05625 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC645_RS05630 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HC645_RS05635 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HC645_RS05640 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HC645_RS05645 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC645_RS05650 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HC645_RS05655 ENOG4108WMJ Protein of unknown function (DUF2002) HC645_RS05660 ENOG4108RNS Exports L-alanine (By similarity) HC645_RS05670 ENOG4108X73 DNA- binding protein HC645_RS05685 ENOG4108V62 Rhodanese domain protein HC645_RS05690 ENOG41080HT Transcriptional regulator, arsr family HC645_RS05700 ENOG4105CC0 LysR family Transcriptional regulator HC645_RS05705 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HC645_RS05710 ENOG4105C26 Dehydrogenase HC645_RS05715 ENOG4105X0I Fimbrial HC645_RS05720 ENOG4108VCD Chaperone HC645_RS05725 ENOG4105CW0 outer membrane usher protein HC645_RS05735 ENOG4108AF8 Chaperone HC645_RS05755 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HC645_RS05760 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HC645_RS05765 ENOG4105MP9 class II Aldolase HC645_RS05775 ENOG4106TNF Periplasmic binding protein HC645_RS05790 ENOG4105CYW agmatinase HC645_RS05795 ENOG4105EVZ LysR family transcriptional regulator HC645_RS05810 ENOG4105C1P efflux transporter, rnd family, mfp subunit HC645_RS05815 ENOG4105UEI Transcriptional Regulator AraC Family HC645_RS05870 ENOG4105DFP Integrase HC645_RS05880 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HC645_RS05885 ENOG4108Z1B Cyclase dehydrase HC645_RS05895 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HC645_RS05905 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HC645_RS05910 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HC645_RS05915 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HC645_RS05920 ENOG4108JU6 CBS domain protein HC645_RS05925 ENOG4106KVJ cytochrome C assembly protein HC645_RS05930 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HC645_RS05935 ENOG4105K5M 30s ribosomal protein S16 HC645_RS05940 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HC645_RS05945 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HC645_RS05950 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HC645_RS05970 ENOG41090EK ompa motb domain protein HC645_RS05975 ENOG4108KHX Diguanylate cyclase HC645_RS05980 ENOG4108WS1 HC645_RS05985 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HC645_RS05990 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HC645_RS06000 ENOG4105CQC Prephenate dehydratase HC645_RS06010 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HC645_RS06015 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HC645_RS06020 ENOG4105C34 Pseudouridine synthase HC645_RS06025 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HC645_RS06030 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HC645_RS06055 ENOG4105CSH Transporter HC645_RS06060 ENOG4105T42 (LipO)protein HC645_RS06065 ENOG4105JIM Phosphatidylserine synthase HC645_RS06070 ENOG4105CD5 CoA-binding domain protein HC645_RS06075 ENOG4106IUH DTW domain containing protein HC645_RS06080 ENOG4105K63 Thioredoxin HC645_RS06085 ENOG4105EIB trna rrna methyltransferase HC645_RS06090 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HC645_RS06095 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HC645_RS06100 ENOG4105C1J atp-dependent rna helicase HC645_RS06105 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HC645_RS06110 ENOG4108IYU L-aspartate oxidase HC645_RS06125 ENOG41069PW sigma-e factor negative regulatory protein HC645_RS06130 ENOG4105VQK sigma E regulatory protein, MucB RseB HC645_RS06135 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HC645_RS06140 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HC645_RS06145 ENOG4105C3F Signal peptidase i HC645_RS06150 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HC645_RS06155 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HC645_RS06160 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HC645_RS06165 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HC645_RS06170 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HC645_RS06175 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HC645_RS06180 ENOG4106G6Q Transcriptional regulator HC645_RS06185 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HC645_RS06190 ENOG4108Z6B deaminase HC645_RS06195 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HC645_RS06200 ENOG4108ETH Formylglycinamide ribotide synthetase HC645_RS06205 ENOG4107WP9 Histidine kinase HC645_RS06210 ENOG4108SKK alpha helix protein HC645_RS06215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HC645_RS06220 ENOG4108YZA Nitrogen regulatory protein pii HC645_RS06225 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HC645_RS06230 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HC645_RS06235 ENOG4108SB3 DoxX Family HC645_RS06240 ENOG4108NZE NAGC-like transcriptional regulator HC645_RS06245 ENOG4107HQ7 repeat protein HC645_RS06250 ENOG4107QNK )-transporter HC645_RS06255 ENOG4108ZKT aldose 1-epimerase HC645_RS06260 ENOG4105D8G Major Facilitator superfamily HC645_RS06265 ENOG4108MN2 Stationary phase inducible protein CsiE HC645_RS06270 ENOG41065CD Exported protein HC645_RS06275 ENOG4105D7X high-affinity nickel-transporter HC645_RS06285 ENOG4105ECY inositol monophosphatase HC645_RS06290 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HC645_RS06295 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HC645_RS06300 ENOG4105C3J Cysteine desulfurase HC645_RS06305 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HC645_RS06310 ENOG4108Z4V iron-sulfur cluster assembly HC645_RS06315 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HC645_RS06320 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HC645_RS06325 ENOG4108ZIT Ferredoxin, 2FE-2S HC645_RS06330 ENOG4105WVQ Fe-S assembly protein IscX HC645_RS06335 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HC645_RS06340 ENOG4105YYA enhanced serine sensitivity protein SseB HC645_RS06350 ENOG4105KHC sulfurtransferase HC645_RS06355 ENOG4105DN3 alpha-2-macroglobulin domain protein HC645_RS06360 ENOG4108JQB penicillin-binding protein 1C HC645_RS06365 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HC645_RS06370 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HC645_RS06375 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HC645_RS06380 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HC645_RS06390 ENOG4105N21 Membrane HC645_RS06395 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HC645_RS06400 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HC645_RS06410 ENOG4105VPD cellular component movement HC645_RS06415 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HC645_RS06420 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HC645_RS06425 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HC645_RS06435 ENOG4105C4X radical SAM domain protein HC645_RS06450 ENOG41062G3 Protein of unknown function (DUF2633) HC645_RS06455 ENOG4105BZU Histidine kinase HC645_RS06460 ENOG4105C9X ppx gppa phosphatase HC645_RS06465 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HC645_RS06470 ENOG4108V3E phosphoribosylglycinamide formyltransferase HC645_RS06475 ENOG4105CXB phosphoribosylaminoimidazole synthetase HC645_RS06480 ENOG41066F8 ROK family HC645_RS06485 ENOG4105CS2 ec 3.2.1.21 HC645_RS06490 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HC645_RS06495 ENOG4105C2W permease HC645_RS06500 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HC645_RS06510 ENOG4105K89 arsenate reductase HC645_RS06515 ENOG4105ERG peptidase m48, ste24p HC645_RS06525 ENOG4105C02 permease HC645_RS06530 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC645_RS06535 ENOG4105RH4 Glycine cleavage system transcriptional repressor HC645_RS06540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HC645_RS06545 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HC645_RS06550 ENOG4105C8V SAICAR synthetase HC645_RS06555 ENOG4105CGZ zinc metallopeptidase HC645_RS06560 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HC645_RS06565 ENOG4106KED esterase YpfH HC645_RS06570 ENOG4105XYK UPF0370 protein HC645_RS06575 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HC645_RS06580 ENOG4105KUZ arsenate reductase HC645_RS06590 ENOG4105BZS acriflavin resistance protein HC645_RS06595 ENOG4105BZ8 glutamate synthase HC645_RS06600 ENOG4107VIJ nudix hydrolase HC645_RS06605 ENOG4108PVD exported protein HC645_RS06610 ENOG4105CV1 Transketolase (EC 2.2.1.1) HC645_RS06615 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HC645_RS06620 ENOG4105C6K Malic enzyme HC645_RS06625 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HC645_RS06630 ENOG4106S4J ethanolamine utilization protein EutP HC645_RS06635 ENOG4105NDK ethanolamine utilization protein HC645_RS06640 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HC645_RS06645 ENOG4108IJ2 phosphate acetyltransferase HC645_RS06650 ENOG4105KNY Microcompartments protein HC645_RS06655 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HC645_RS06660 ENOG4108EKI Dehydrogenase HC645_RS06665 ENOG4107YMV ethanolamine utilization protein HC645_RS06670 ENOG4105C0A alcohol dehydrogenase HC645_RS06675 ENOG4105ENY Ethanolamine utilization protein eutH HC645_RS06680 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HC645_RS06685 ENOG4105CPD ethanolamine ammonia-lyase HC645_RS06695 ENOG4106D67 ethanolamine utilization protein HC645_RS06700 ENOG4108X49 Ethanolamine utilization protein EutK HC645_RS06705 ENOG4108K3Z AraC family transcriptional regulator HC645_RS06710 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HC645_RS06715 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HC645_RS06720 ENOG4108R6G acetyltransferase HC645_RS06725 ENOG4105QZU Inner membrane protein YfeZ HC645_RS06730 ENOG4105E7K (LipO)protein HC645_RS06735 ENOG4105EZR dyp-type peroxidase family protein HC645_RS06745 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HC645_RS06750 ENOG4108I5D sulfate abc transporter HC645_RS06755 ENOG4105ECW sulfate abc transporter HC645_RS06760 ENOG4108IJ6 ABC transporter HC645_RS06765 ENOG4105C6T cysteine synthase HC645_RS06770 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HC645_RS06775 ENOG4105CSW GntR family transcriptional regulator HC645_RS06780 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HC645_RS06790 ENOG4105C5Y PTS System HC645_RS06795 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HC645_RS06800 ENOG4105KZ7 phosphocarrier protein hpr HC645_RS06810 ENOG4105C6T cysteine synthase HC645_RS06815 ENOG4105EXN Sulfate transport protein CysZ HC645_RS06820 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HC645_RS06825 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HC645_RS06830 ENOG4105VRT cytoplasmic protein HC645_RS06835 ENOG4105DHU Bile acid HC645_RS06840 ENOG4108M0I Transcriptional regulator HC645_RS06865 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HC645_RS06870 ENOG4105GXM Putative transcription regulator (DUF1323) HC645_RS06875 ENOG4105HZG regulatoR HC645_RS06885 ENOG4108KMM Diguanylate cyclase HC645_RS06890 ENOG4105D9N nucleoside HC645_RS06895 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HC645_RS06900 ENOG4109076 Conserved Protein HC645_RS06905 ENOG4105CPC Aldo Keto reductase HC645_RS06910 ENOG4107RA9 decarboxylase HC645_RS06920 ENOG4105CHC glucokinase (EC 2.7.1.2) HC645_RS06925 ENOG4105DY9 regulatoR HC645_RS06930 ENOG4108HRK Histidine kinase HC645_RS06945 ENOG4105CHM Aminotransferase HC645_RS06955 ENOG4105DJ2 Major Facilitator Superfamily HC645_RS06960 ENOG4108Z6B deaminase HC645_RS06965 ENOG4105DND Transcriptional regulator HC645_RS06985 ENOG4105DFP Integrase HC645_RS07040 ENOG4105RDA repressor HC645_RS07045 ENOG41078CG DNA-binding transcriptional regulator HC645_RS07050 ENOG4108S1U HC645_RS07060 ENOG4105CFI type iii restriction protein res subunit HC645_RS07095 ENOG4105NVB glycoside hydrolase, family 19 HC645_RS07250 ENOG4105EXC Acyl-transferase HC645_RS07255 ENOG4105Y50 Virulence Protein HC645_RS07265 ENOG4105S64 Formate nitrite transporter HC645_RS07270 ENOG410903C (LipO)protein HC645_RS07275 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HC645_RS07280 ENOG4105KZW UPF0381 protein HC645_RS07285 ENOG4105CHU acetyl-coa acetyltransferase HC645_RS07290 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HC645_RS07295 ENOG4108BY2 phosphohistidine phosphatase HC645_RS07300 ENOG4108DG9 Smr protein MutS2 HC645_RS07305 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HC645_RS07310 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HC645_RS07315 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HC645_RS07320 ENOG4105EJ9 Membrane HC645_RS07325 ENOG4108BPE -transporting atpase HC645_RS07330 ENOG4105MH2 YfcL protein HC645_RS07335 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HC645_RS07340 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HC645_RS07345 ENOG4105F9N Major Facilitator Superfamily HC645_RS07350 ENOG4106WZ1 flagella biosynthesis regulator HC645_RS07360 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HC645_RS07365 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HC645_RS07370 ENOG4105DQR SNARE associated Golgi HC645_RS07375 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HC645_RS07380 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HC645_RS07385 ENOG4108S3P Sporulation domain protein HC645_RS07390 ENOG4105E96 Colicin v production protein HC645_RS07395 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HC645_RS07400 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HC645_RS07410 ENOG4105E89 ABC transporter HC645_RS07415 ENOG4105E89 ABC transporter HC645_RS07420 ENOG4105DSP amino acid AbC transporter HC645_RS07425 ENOG4106YG3 ABC transporter HC645_RS07430 ENOG4108JEH abc transporter atp-binding protein HC645_RS07435 ENOG4105KNA -acetyltransferase HC645_RS07445 ENOG4105ECP epimerase HC645_RS07450 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HC645_RS07455 ENOG4105CYM Glutathione S-transferase HC645_RS07460 ENOG4108SHQ Glutathione S-transferase HC645_RS07465 ENOG4108RE9 Phosphodiesterase HC645_RS07470 ENOG4105PTV Nudix Hydrolase HC645_RS07475 ENOG4105C6K Malic enzyme HC645_RS07480 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HC645_RS07485 ENOG4105PQ6 UPF0208 membrane protein HC645_RS07495 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HC645_RS07500 ENOG4107QWE )-transporter HC645_RS07505 ENOG4105DK2 UPF0207 protein HC645_RS07510 ENOG4105CHM Aminotransferase HC645_RS07515 ENOG4107NQ8 LysR family Transcriptional regulator HC645_RS07525 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HC645_RS07530 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HC645_RS07535 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HC645_RS07540 ENOG4105GKE subunit e HC645_RS07545 ENOG4107QIZ NADH dehydrogenase HC645_RS07550 ENOG4108IEH NADH dehydrogenase subunit g HC645_RS07555 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HC645_RS07565 ENOG4107UFS subunit j HC645_RS07570 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HC645_RS07575 ENOG4105D65 subunit l HC645_RS07580 ENOG4105C8S subunit m HC645_RS07585 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HC645_RS07590 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HC645_RS07595 ENOG4107YB6 acetyltransferase, (GNAT) family HC645_RS07600 ENOG4105E4F Isochorismate synthase HC645_RS07605 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HC645_RS07610 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HC645_RS07615 ENOG4108IPT Naphthoate synthase HC645_RS07620 ENOG4105DNI Converts SHCHC to OSB (By similarity) HC645_RS07625 ENOG4105CEY Amp-dependent synthetase and ligase HC645_RS07635 ENOG4105DNE Transposase HC645_RS07645 ENOG4108UII YfaZ family HC645_RS07650 ENOG4108EWA cinA-like protein HC645_RS07655 ENOG4107258 Transcriptional regulator HC645_RS07660 ENOG4105CXK mandelate racemase muconate lactonizing HC645_RS07665 ENOG4105CSP Major Facilitator Superfamily HC645_RS07670 ENOG4105CNV Aldolase HC645_RS07675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HC645_RS07680 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HC645_RS07685 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HC645_RS07690 ENOG4105CXY transporter HC645_RS07695 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HC645_RS07700 ENOG4105XPH Ferredoxin HC645_RS07705 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC645_RS07710 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC645_RS07715 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HC645_RS07720 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC645_RS07725 ENOG4105BZU Histidine kinase HC645_RS07730 ENOG41068CG regulatoR HC645_RS07735 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HC645_RS07750 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HC645_RS07755 ENOG4105CF1 Alkylated DNA repair protein HC645_RS07760 ENOG4105IBP Cyclic peptide transporter HC645_RS07765 ENOG4105CJW magnesium transporter HC645_RS07770 ENOG4105CHH sulfate transporter HC645_RS07785 ENOG4105F4G Membrane HC645_RS07795 ENOG4105E68 Sulfatase HC645_RS07800 ENOG4105PAN UPF0352 protein HC645_RS07805 ENOG4106V8H Nucleoid-associated protein HC645_RS07810 ENOG4105N2W Transcriptional regulator HC645_RS07815 ENOG4107VIJ nudix hydrolase HC645_RS07830 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HC645_RS07835 ENOG4105CFI type iii restriction protein res subunit HC645_RS07840 ENOG4105I08 Pseudouridine synthase HC645_RS07845 ENOG4105C2C drug resistance transporter, Bcr CflA HC645_RS07850 ENOG4105HG6 HC645_RS07855 ENOG4108JQ5 ABC transporter HC645_RS07860 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HC645_RS07865 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HC645_RS07870 ENOG4105E43 Extracellular solute-binding protein, family 5 HC645_RS07875 ENOG4105CXC rtn protein HC645_RS07880 ENOG4107TT5 NLP P60 protein HC645_RS07885 ENOG41076MN Phosphoesterase, PA-phosphatase related HC645_RS07890 ENOG4105CKI cobalamin synthesis protein HC645_RS07895 ENOG4105DEI Mannitol dehydrogenase HC645_RS07900 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HC645_RS07910 ENOG4105KRS Proteinase inhibitor HC645_RS07915 ENOG4105S8Q sugar efflux transporter HC645_RS07920 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HC645_RS07925 ENOG4105DE4 1-phosphofructokinase HC645_RS07930 ENOG4105DM4 PTS System HC645_RS07935 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HC645_RS07940 ENOG4105HMI Membrane HC645_RS07945 ENOG4105DUM transcriptional regulator, lysR family HC645_RS07950 ENOG4108IQI permease HC645_RS07955 ENOG4105D05 Receptor HC645_RS07965 ENOG4105EUJ GTP cyclohydrolase i HC645_RS07970 ENOG4105DHF Membrane HC645_RS07975 ENOG41060NJ transcriptional regulator HC645_RS07985 ENOG4105C2J ABC transporter HC645_RS07990 ENOG4107SDZ Galactoside transport system permease protein mglC HC645_RS07995 ENOG4107GZ4 SanA protein HC645_RS08000 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HC645_RS08005 ENOG41067MG lrgb family HC645_RS08010 ENOG4105VAW lrga family HC645_RS08015 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HC645_RS08020 ENOG4105TW1 Carbohydrate-selective porin OprB HC645_RS08035 ENOG4105CS2 ec 3.2.1.21 HC645_RS08045 ENOG4105KHU inner membrane protein YohD HC645_RS08050 ENOG41069YE inner membrane protein yohC HC645_RS08055 ENOG41061WM D-Alanyl-D-Alanine HC645_RS08070 ENOG4105CXG d-lactate dehydrogenase HC645_RS08075 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HC645_RS08080 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HC645_RS08085 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HC645_RS08090 ENOG4108IJ8 ABC transporter HC645_RS08095 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HC645_RS08105 ENOG4108HRK Histidine kinase HC645_RS08110 ENOG4108NEV two component transcriptional regulator, LytTR family HC645_RS08115 ENOG4108W15 Protein of unknown function (DUF1456) HC645_RS08120 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HC645_RS08125 ENOG4105D1F ATP-binding protein HC645_RS08135 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HC645_RS08140 ENOG4105EJC lysr family transcriptional regulator HC645_RS08145 ENOG4105C7N Xanthine uracil vitamin C permease HC645_RS08150 ENOG4105CPN adenine deaminase HC645_RS08155 ENOG4105DUM transcriptional regulator, lysR family HC645_RS08165 ENOG4105EUZ Beta-lactamase domain protein HC645_RS08195 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HC645_RS08200 ENOG4105DWF phosphomethylpyrimidine kinase HC645_RS08205 ENOG4105EIE fructose-bisphosphate aldolase HC645_RS08210 ENOG4105IE8 Alpha-ketoglutarate permease HC645_RS08235 ENOG4105DEI Mannitol dehydrogenase HC645_RS08240 ENOG4105CMG Carbohydrate kinase HC645_RS08245 ENOG4105IE8 Alpha-ketoglutarate permease HC645_RS08250 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HC645_RS08255 ENOG4105CXK mandelate racemase muconate lactonizing HC645_RS08260 ENOG4105DEF Extracellular solute-binding protein, family 5 HC645_RS08265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC645_RS08270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS08280 ENOG4108JQ7 (ABC) transporter HC645_RS08290 ENOG4105CFP Peptidase U32 HC645_RS08295 ENOG4105E3W Two component transcriptional regulator (Winged helix family HC645_RS08300 ENOG4105EB3 Histidine kinase HC645_RS08305 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC645_RS08310 ENOG4105BZS acriflavin resistance protein HC645_RS08315 ENOG4105BZS acriflavin resistance protein HC645_RS08320 ENOG4105ENT Efflux transporter rnd family, mfp subunit HC645_RS08325 ENOG4105CK2 sodium dicarboxylate symporter HC645_RS08345 ENOG4105BZU Histidine kinase HC645_RS08350 ENOG4105R8A Heat shock protein HC645_RS08355 ENOG4105D03 DNA-3-methyladenine glycosylase II HC645_RS08360 ENOG4105DBI uridine monophosphokinase HC645_RS08365 ENOG4105DHP deoxycytidine triphosphate deaminase HC645_RS08370 ENOG4108GAE asmA family HC645_RS08375 ENOG4105EE5 Membrane protein terC HC645_RS08380 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HC645_RS08385 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HC645_RS08390 ENOG4108MRJ HC645_RS08395 ENOG4105DAY polysaccharide export protein HC645_RS08400 ENOG4107ZF2 Phosphatase HC645_RS08425 ENOG4107XU6 Glycosyl transferase (Group 1 HC645_RS08430 ENOG4108UW5 maltose o-acetyltransferase HC645_RS08435 ENOG4105C0K Gdp-mannose 4,6-dehydratase HC645_RS08440 ENOG4105C30 Nad-dependent epimerase dehydratase HC645_RS08445 ENOG4105FGF GDP-mannose mannosyl hydrolase HC645_RS08450 ENOG4106CD9 glycosyl transferase group 1 HC645_RS08460 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HC645_RS08520 ENOG4105CPK Glycosyl transferase (Group 1 HC645_RS08545 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HC645_RS08550 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HC645_RS08560 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HC645_RS08565 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HC645_RS08570 ENOG4105CIH Imidazole acetol-phosphate transaminase HC645_RS08580 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HC645_RS08590 ENOG4107SRH Nad-dependent epimerase dehydratase HC645_RS08595 ENOG4105EQ1 Transcriptional regulator HC645_RS08605 ENOG4105CUB amino acid HC645_RS08610 ENOG4105YVS arsR family transcriptional regulator HC645_RS08615 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HC645_RS08620 ENOG4105CJB Exodeoxyribonuclease I HC645_RS08625 ENOG4105DZ1 carboxypeptidase HC645_RS08635 ENOG4105DR8 Membrane HC645_RS08640 ENOG41090HJ UPF0265 protein HC645_RS08645 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HC645_RS08650 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HC645_RS08655 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HC645_RS08665 ENOG41090U3 tautomerase HC645_RS08670 ENOG4105HEI LysR family (Transcriptional regulator HC645_RS08675 ENOG4108KMH lipoate-protein ligase a HC645_RS08680 ENOG4105CSH Transporter HC645_RS08690 ENOG4105BZU Histidine kinase HC645_RS08700 ENOG4108YS1 cytoplasmic protein HC645_RS08705 ENOG4105YP6 Domain of unknown function (DUF1869) HC645_RS08710 ENOG4105ETT transcriptional Regulator, LysR family HC645_RS08725 ENOG4105BZU Histidine kinase HC645_RS08750 ENOG4105UQX Mate efflux family protein HC645_RS08760 ENOG4105FYV Amp nucleosidase HC645_RS08780 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HC645_RS08785 ENOG4108WUH Transcriptional regulator, TetR family HC645_RS08790 ENOG4105EEQ Na H antiporter HC645_RS08810 ENOG4107R11 Transcriptional regulator HC645_RS08815 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HC645_RS08825 ENOG4108UQ8 endoribonuclease L-psp HC645_RS08835 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HC645_RS08845 ENOG4105FCK Membrane HC645_RS08855 ENOG4105Y0K Inner membrane protein YedR HC645_RS08860 ENOG4105EST Metal Dependent Phosphohydrolase HC645_RS08865 ENOG4105DVF Cytosine-specific methyltransferase HC645_RS08870 ENOG41090BB DNA mismatch endonuclease (vsr) HC645_RS08875 ENOG4105FDR Membrane HC645_RS08880 ENOG4105CKW Inner membrane protein yedI HC645_RS08890 ENOG4105YX3 cellular response to acidity HC645_RS08905 ENOG4105JCU Inherit from NOG: (Lipo)protein HC645_RS08910 ENOG4105E5K Alpha-amylase HC645_RS08915 ENOG4105EAB amino acid AbC transporter HC645_RS08920 ENOG4105K6H D-cysteine desulfhydrase HC645_RS08925 ENOG4105E5Q amino acid AbC transporter HC645_RS08930 ENOG4105CDA abc transporter atp-binding protein HC645_RS08935 ENOG4105VJY transcriptional regulator HC645_RS08940 ENOG4105XVG cytoplasmic protein HC645_RS08945 ENOG4105WH1 Two component transcriptional regulator luxr family HC645_RS08980 ENOG4106RHG Yeca family HC645_RS08985 ENOG4105E0U tyrosine-specific transport protein HC645_RS08990 ENOG4105VVZ metal-binding protein HC645_RS08995 ENOG41090A1 ferritin HC645_RS09010 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC645_RS09015 ENOG4105N4N Protein of unknown function (DUF2766) HC645_RS09030 ENOG4108UEC Ferritin-like protein HC645_RS09040 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HC645_RS09050 ENOG4105CNN ABC, transporter HC645_RS09060 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HC645_RS09065 ENOG4108VA4 Universal stress protein HC645_RS09070 ENOG4105CT4 transporter HC645_RS09075 ENOG4105F5H Glycosyl Hydrolase Family 88 HC645_RS09080 ENOG4105C75 arginyL-tRNA synthetase HC645_RS09085 ENOG4106ZCM YecM protein HC645_RS09090 ENOG4106N3A copper homeostasis protein cutc HC645_RS09095 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HC645_RS09100 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HC645_RS09105 ENOG4105WJG Glutathione HC645_RS09110 ENOG41081XQ Conserved Protein HC645_RS09115 ENOG4105D3W isochorismatase HC645_RS09120 ENOG4105C9M aspartyl-trna synthetase HC645_RS09125 ENOG4108TIT dATP pyrophosphohydrolase HC645_RS09130 ENOG4105CDY transcriptional regulatory protein HC645_RS09135 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HC645_RS09140 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HC645_RS09145 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HC645_RS09150 ENOG4105FAV ABC, transporter HC645_RS09160 ENOG4105NXV High-affinity zinc uptake system protein HC645_RS09165 ENOG4105DR5 peptidase HC645_RS09170 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HC645_RS09175 ENOG4105CA9 Pyruvate kinase HC645_RS09180 ENOG4106KNT transcriptional regulator HC645_RS09190 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HC645_RS09195 ENOG4105C01 Dihydroxy-acid dehydratase HC645_RS09200 ENOG4108UHU Aldolase HC645_RS09210 ENOG4105X2V dna damage-inducible protein HC645_RS09215 ENOG4108Q2J Inner membrane protein YebE HC645_RS09220 ENOG4105CUG Oligopeptidase b HC645_RS09225 ENOG4105UMD exodeoxyribonuclease X HC645_RS09230 ENOG4105MPK DNA polymerase III subunit theta HC645_RS09235 ENOG4105FXM Copper resistance protein HC645_RS09240 ENOG4108PNC copper resistance HC645_RS09245 ENOG4105NKT exported protein HC645_RS09255 ENOG4108MJ5 VirK protein HC645_RS09260 ENOG4108R1E Serine threonine protein phosphatase 1 HC645_RS09265 ENOG4105UVW uncharacterized protein yebW HC645_RS09270 ENOG4105WT8 Protein of unknown function (DUF1480) HC645_RS09275 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HC645_RS09280 ENOG4105DY2 Paraquat-inducible protein b HC645_RS09285 ENOG4105H2K paraquat-inducible protein a HC645_RS09290 ENOG4108ZGC gaf domain protein HC645_RS09295 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HC645_RS09300 ENOG4105CN1 protease HC645_RS09305 ENOG4105D0M Protease HtpX homolog HC645_RS09310 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC645_RS09315 ENOG4105J4Q Transcriptional regulator HC645_RS09320 ENOG4105TIK HC645_RS09330 ENOG4105Q3Y exported protein HC645_RS09350 ENOG4105CJN penicillin-binding protein HC645_RS09355 ENOG4105DHI Methyltransferase HC645_RS09360 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HC645_RS09365 ENOG4108NK4 UPF0266 membrane protein HC645_RS09370 ENOG4105F3R pts system mannose fructose sorbose family iid HC645_RS09375 ENOG4105ETZ PTS System HC645_RS09380 ENOG4105DAS pts system HC645_RS09385 ENOG4105EE5 Membrane protein terC HC645_RS09390 ENOG4107XTP (EAL) domain protein HC645_RS09400 ENOG4105EJQ L-serine dehydratase HC645_RS09405 ENOG4105P8F nudix hydrolase HC645_RS09415 ENOG4105X5C UPF0181 protein HC645_RS09420 ENOG4105EY3 heparinase II III family protein HC645_RS09430 ENOG4105E0S extracellular solute-binding protein family 1 HC645_RS09440 ENOG4105DRS transport system, permease HC645_RS09455 ENOG4105M4H endoribonuclease L-psp HC645_RS09460 ENOG4105DVT helicase HC645_RS09465 ENOG41072GX Peptidase M22 Glycoprotease HC645_RS09470 ENOG4105Y4Z Outer Membrane Lipoprotein HC645_RS09475 ENOG4105CEY Amp-dependent synthetase and ligase HC645_RS09480 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HC645_RS09485 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HC645_RS09490 ENOG4107QMS site-determining protein HC645_RS09495 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HC645_RS09500 ENOG4105VNG YcgL domain-containing protein HC645_RS09505 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HC645_RS09510 ENOG4108ZZ3 UPF0260 protein HC645_RS09520 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HC645_RS09525 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HC645_RS09530 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HC645_RS09535 ENOG4105ED1 spovr family HC645_RS09545 ENOG4105MWK D-amino acid dehydrogenase, small subunit HC645_RS09555 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HC645_RS09560 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HC645_RS09565 ENOG4106JQ5 Transglycosylase SLT domain HC645_RS09570 ENOG4105E0K tonB-dependent siderophore receptor HC645_RS09630 ENOG410811B TRANSCRIPTIONal HC645_RS09635 ENOG4105C7B Threonine dehydratase HC645_RS09640 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HC645_RS09650 ENOG4105C6N Formate acetyltransferase HC645_RS09665 ENOG4105C32 Amino acid ABC transporter (Permease) HC645_RS09670 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HC645_RS09675 ENOG4105C0Z ABC transporter HC645_RS09680 ENOG4108IV0 ABC, transporter HC645_RS09685 ENOG4107YNJ LysR family Transcriptional regulator HC645_RS09705 ENOG4105CSH Transporter HC645_RS09715 ENOG4105F04 LysR family Transcriptional regulator HC645_RS09725 ENOG4105D3G Pseudouridine synthase HC645_RS09730 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HC645_RS09755 ENOG4108ZG0 Ompa motb domain protein HC645_RS09765 ENOG4105CS6 Rhs element vgr protein HC645_RS09770 ENOG4106678 morphogenetic protein associated with SpoVID HC645_RS09835 ENOG4105C3G gtp-binding protein HC645_RS09840 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HC645_RS09845 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HC645_RS09855 ENOG4105CHH sulfate transporter HC645_RS09860 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HC645_RS09865 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HC645_RS09875 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HC645_RS09880 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HC645_RS09885 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HC645_RS09890 ENOG4108YY7 Invasion gene expression up-regulator SirB HC645_RS09895 ENOG41063JG Transcriptional regulator HC645_RS09900 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HC645_RS09905 ENOG4105EWV Sodium calcium exchanger membrane region HC645_RS09910 ENOG4105WS7 Cation transport regulator HC645_RS09915 ENOG4108NH8 Cation transport protein HC645_RS09925 ENOG41090EX DsrE family HC645_RS09940 ENOG4105I5W Transporter HC645_RS09950 ENOG4105D7T ABC transporter HC645_RS09955 ENOG4107QZF nitrite reductase NADPH large subunit HC645_RS09965 ENOG4105ID0 Putative invasin HC645_RS09970 ENOG4105WH1 Two component transcriptional regulator luxr family HC645_RS09975 ENOG4105BZU Histidine kinase HC645_RS09980 ENOG4105DQQ Major facilitator superfamily MFS_1 HC645_RS09990 ENOG4105CRU nitrate reductase, alpha subunit HC645_RS09995 ENOG4108IUE nitrate reductase beta subunit HC645_RS10000 ENOG4105R3A Nitrate reductase HC645_RS10005 ENOG41076YT nitrate reductase, gamma subunit HC645_RS10050 ENOG4105CIY formyltetrahydrofolate deformylase HC645_RS10060 ENOG4105D78 K07001 NTE family protein HC645_RS10065 ENOG4105I93 response regulator HC645_RS10070 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HC645_RS10085 ENOG4107104 thymidine kinase HC645_RS10090 ENOG4105C0A alcohol dehydrogenase HC645_RS10100 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HC645_RS10110 ENOG4108J59 Extracellular solute-binding protein, family 5 HC645_RS10115 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC645_RS10120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS10125 ENOG4105C3U ABC transporter HC645_RS10130 ENOG4108JQ7 (ABC) transporter HC645_RS10135 ENOG4105EYW Ion transport protein HC645_RS10140 ENOG4108W5H UPF0263 protein HC645_RS10145 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HC645_RS10155 ENOG4108YYC ycei family HC645_RS10165 ENOG4105K9H YciI-like protein HC645_RS10170 ENOG410822N TonB family HC645_RS10180 ENOG4105P10 Uncharacterized protein ydiZ HC645_RS10185 ENOG4105DE4 1-phosphofructokinase HC645_RS10190 ENOG4108NE3 Salt-induced outer membrane protein HC645_RS10205 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HC645_RS10210 ENOG41082NX 50s ribosomal protein l35 HC645_RS10225 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HC645_RS10230 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HC645_RS10235 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HC645_RS10245 ENOG4105MWK D-amino acid dehydrogenase, small subunit HC645_RS10250 ENOG4105RQF LysR family Transcriptional regulator HC645_RS10260 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HC645_RS10265 ENOG4105D01 (LipO)protein HC645_RS10270 ENOG4108V06 Glutathione peroxidase HC645_RS10280 ENOG4108QBX (LipO)protein HC645_RS10285 ENOG4105CNG UPF0061 protein HC645_RS10295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HC645_RS10310 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HC645_RS10320 ENOG4105IPI Membrane HC645_RS10325 ENOG4105CQB FAD linked oxidase domain protein HC645_RS10330 ENOG4105KA0 thioesterase Superfamily protein HC645_RS10335 ENOG4105Y3U Transglycosylase-associated protein HC645_RS10350 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HC645_RS10360 ENOG4105E0A ABC, transporter HC645_RS10365 ENOG4105EHG Permease protein HC645_RS10375 ENOG4106KR7 LysR family Transcriptional regulator HC645_RS10400 ENOG4105DMF Dehydrogenase HC645_RS10415 ENOG4108Z4V iron-sulfur cluster assembly HC645_RS10420 ENOG4105DIW FeS assembly protein SUFB HC645_RS10425 ENOG4105C3K feS assembly ATPase SufC HC645_RS10430 ENOG4105JRK feS assembly protein SufD HC645_RS10435 ENOG4105C9B Cysteine desulfurase HC645_RS10440 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HC645_RS10445 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HC645_RS10455 ENOG4105CA9 Pyruvate kinase HC645_RS10470 ENOG4105RFR Protein of unknown function (DUF2767) HC645_RS10485 ENOG4105DJB Major Facilitator Superfamily HC645_RS10490 ENOG4105E2X shikimate dehydrogenase HC645_RS10495 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HC645_RS10500 ENOG4108W0P ABC transporter HC645_RS10505 ENOG4105EHG Permease protein HC645_RS10510 ENOG4105S10 periplasmic binding protein HC645_RS10515 ENOG4108K2P TRANSCRIPTIONal HC645_RS10520 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HC645_RS10525 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) HC645_RS10530 ENOG4107UB2 Alpha beta hydrolase fold HC645_RS10535 ENOG4105IKQ hydratase HC645_RS10545 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HC645_RS10550 ENOG4108SC4 )-transporter HC645_RS10565 ENOG4108T2C cysteine dioxygenase type I HC645_RS10570 ENOG4106KR7 LysR family Transcriptional regulator HC645_RS10575 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HC645_RS10595 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HC645_RS10600 ENOG4108IY8 ABC, transporter HC645_RS10610 ENOG4105E0A ABC, transporter HC645_RS10615 ENOG4105DQ5 transport system permease protein HC645_RS10635 ENOG4106PMH Extracellular solute-binding protein family 3 HC645_RS10640 ENOG4105E5Q amino acid AbC transporter HC645_RS10645 ENOG4105CDA abc transporter atp-binding protein HC645_RS10650 ENOG4105KZM cytoplasmic protein HC645_RS10660 ENOG41083G8 Multidrug resistance protein MdtM HC645_RS10685 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HC645_RS10690 ENOG4105DG4 malate L-lactate dehydrogenase HC645_RS10700 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HC645_RS10705 ENOG4107Z33 ABC transporter, permease HC645_RS10735 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HC645_RS10740 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HC645_RS10745 ENOG41060IM Heme exporter protein HC645_RS10755 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HC645_RS10760 ENOG4105DA4 cytochrome c-type biogenesis protein HC645_RS10765 ENOG4107QX9 Thiol disulfide interChange protein HC645_RS10770 ENOG4105KWW Biogenesis protein HC645_RS10795 ENOG41062D9 Histidine kinase HC645_RS10800 ENOG4105E3W Two component transcriptional regulator (Winged helix family HC645_RS10815 ENOG4105BZS acriflavin resistance protein HC645_RS10830 ENOG4105CHR reductase HC645_RS10835 ENOG4105C7K acetolactate synthase HC645_RS10850 ENOG4105DTD Dehydrogenase HC645_RS10855 ENOG4105CY2 Citrate transporter HC645_RS10860 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HC645_RS10865 ENOG4105CHU acetyl-coa acetyltransferase HC645_RS10870 ENOG4107QNJ CoA-transferase subunit B HC645_RS10880 ENOG4106NZI LysR family Transcriptional regulator HC645_RS10910 ENOG4105DXI Major Facilitator superfamily HC645_RS10940 ENOG4105CQB FAD linked oxidase domain protein HC645_RS10945 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HC645_RS10965 ENOG4105KME endoribonuclease L-psp HC645_RS10970 ENOG4107TTD cytosine deaminase HC645_RS10980 ENOG4105EMY transcriptional regulator HC645_RS11025 ENOG4108JQ7 (ABC) transporter HC645_RS11030 ENOG4105C3U ABC transporter HC645_RS11055 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HC645_RS11060 ENOG4105E98 transcriptional regulator DeoR family HC645_RS11070 ENOG4107B2H carbonic anhydrase HC645_RS11100 ENOG4105CY0 Metallo-Beta-Lactamase HC645_RS11150 ENOG4108URH decarboxylase HC645_RS11160 ENOG4107QI1 Mate efflux family protein HC645_RS11165 ENOG4108R6K riboflavin synthase, subunit alpha HC645_RS11170 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HC645_RS11175 ENOG4105CZQ inner membrane transport protein YdhC HC645_RS11180 ENOG4105F52 Transcriptional regulator HC645_RS11185 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS11195 ENOG4105F27 Major Facilitator HC645_RS11200 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HC645_RS11210 ENOG4105K4H Nlp p60 protein HC645_RS11215 ENOG4105M2J Glutaredoxin HC645_RS11220 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HC645_RS11225 ENOG4108UYE Lactoylglutathione lyase HC645_RS11230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HC645_RS11235 ENOG4108WUH Transcriptional regulator, TetR family HC645_RS11240 ENOG4105XZD Fe-S protein HC645_RS11245 ENOG4107RGM aldo keto reductase HC645_RS11250 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HC645_RS11255 ENOG4105DSW Fusaric acid resistance protein HC645_RS11260 ENOG4105Y49 secretion protein, HlyD family HC645_RS11275 ENOG4105BZU Histidine kinase HC645_RS11280 ENOG4108XTF Outer Membrane Lipoprotein HC645_RS11285 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HC645_RS11290 ENOG410642K Lysozyme inhibitor HC645_RS11295 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HC645_RS11300 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HC645_RS11305 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HC645_RS11310 ENOG4108K3A Glutathione S-transferase HC645_RS11320 ENOG4105CSM endonuclease III HC645_RS11330 ENOG4108UQQ Electron transport complex HC645_RS11355 ENOG4105M9B inner membrane protein ydgK HC645_RS11365 ENOG4105CS2 ec 3.2.1.21 HC645_RS11375 ENOG4105D9R oxidoreductase HC645_RS11380 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HC645_RS11385 ENOG4105EQ0 Major Facilitator superfamily HC645_RS11405 ENOG4105CPW cytochrome b561 HC645_RS11425 ENOG4105DDW LysR family Transcriptional regulator HC645_RS11430 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HC645_RS11435 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HC645_RS11440 ENOG4105E32 cytoplasmic protein HC645_RS11445 ENOG4105EBR Carboxylesterase HC645_RS11460 ENOG4108Z9I -acetyltransferase HC645_RS11465 ENOG4107WE3 acetyltransferase YdcK HC645_RS11470 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HC645_RS11475 ENOG41088CC tellurite resistance protein tehB HC645_RS11480 ENOG4108KKZ (LipO)protein HC645_RS11490 ENOG4105UEI Transcriptional Regulator AraC Family HC645_RS11495 ENOG4105DKK Benzoate HC645_RS11500 ENOG4108JCI Transcriptional regulator HC645_RS11510 ENOG4105CFP Peptidase U32 HC645_RS11530 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HC645_RS11535 ENOG4105C4M (Ubiquinol oxidase) subunit I HC645_RS11540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC645_RS11545 ENOG4107TYH extracellular solute-binding protein family 1 HC645_RS11550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HC645_RS11555 ENOG4105D81 ABC transporter, permease HC645_RS11560 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HC645_RS11565 ENOG4105C26 Dehydrogenase HC645_RS11590 ENOG410654E Membrane HC645_RS11595 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HC645_RS11610 ENOG4105DEF Extracellular solute-binding protein, family 5 HC645_RS11615 ENOG4105R71 cytoplasmic protein HC645_RS11620 ENOG4108T9Y Inner membrane protein ydcZ HC645_RS11625 ENOG4108Z7F N-acetyltransferase HC645_RS11635 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HC645_RS11640 ENOG4105DU0 nucleoside hydrolase HC645_RS11645 ENOG41065TG regulatoR HC645_RS11650 ENOG4105CI2 imidazolone-5-propionate hydrolase HC645_RS11655 ENOG4105CHB tonB-dependent Receptor HC645_RS11660 ENOG4108NS2 receptor HC645_RS11670 ENOG4105C85 amino acid HC645_RS11675 ENOG4105EQ2 LysR family Transcriptional regulator HC645_RS11685 ENOG4105DEN Luciferase family HC645_RS11700 ENOG4105EAB amino acid AbC transporter HC645_RS11710 ENOG4105DRP amino acid AbC transporter HC645_RS11715 ENOG4105CDA abc transporter atp-binding protein HC645_RS11725 ENOG4108N27 Glutathione S-transferase HC645_RS11730 ENOG4105KZK Tautomerase pptA HC645_RS11750 ENOG4105CT4 transporter HC645_RS11765 ENOG4108MEJ flavin reductase domain protein HC645_RS11770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HC645_RS11775 ENOG4105C4Y ABC transporter HC645_RS11780 ENOG4107RCV ABC transporter, permease HC645_RS11785 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HC645_RS11790 ENOG4105D0D Nitrate reductase 2, gamma subunit HC645_RS11795 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HC645_RS11800 ENOG4108IUE nitrate reductase beta subunit HC645_RS11805 ENOG4105CRU nitrate reductase, alpha subunit HC645_RS11810 ENOG4107QND Nitrite extrusion protein HC645_RS11825 ENOG4107HP6 Transcriptional regulator HC645_RS11830 ENOG4105DTQ mandelate racemase muconate lactonizing HC645_RS11835 ENOG4105NN7 muconolactone delta-isomerase HC645_RS11840 ENOG410626B catechol 1,2-dioxygenase HC645_RS11850 ENOG4108UKV benzoate 1,2-dioxygenase HC645_RS11875 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HC645_RS11880 ENOG4108MG3 formate dehydrogenase HC645_RS11895 ENOG4105CSR polyphosphate kinase 2 HC645_RS11905 ENOG4105F27 Major Facilitator HC645_RS11920 ENOG4108JQ6 ABC transporter HC645_RS11925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS11940 ENOG4105DQ4 alcohol dehydrogenase HC645_RS11955 ENOG4105C5H ABC transporter HC645_RS11970 ENOG4107R1I NAD-dependent malic enzyme HC645_RS11990 ENOG4105JQN Transcriptional regulator HC645_RS11995 ENOG4105N0E Protein of unknown function (DUF2543) HC645_RS12000 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC645_RS12015 ENOG4108N8X transition metal ion binding HC645_RS12025 ENOG4105CG3 alpha amylase, catalytic region HC645_RS12045 ENOG4108YDI single-species biofilm formation on inanimate substrate HC645_RS12055 ENOG4108Z9K Osmotically inducible protein HC645_RS12080 ENOG4105FFC UPF0187 protein HC645_RS12085 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HC645_RS12090 ENOG4105C5Q Transcriptional regulator HC645_RS12095 ENOG4108KUU Inner membrane metabolite transport protein ydjE HC645_RS12100 ENOG4105KT7 mgtC SapB transporter HC645_RS12105 ENOG4105D6Z AFG1 family ATPase HC645_RS12110 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HC645_RS12115 ENOG4106KR7 LysR family Transcriptional regulator HC645_RS12135 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HC645_RS12140 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HC645_RS12145 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HC645_RS12155 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HC645_RS12160 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HC645_RS12170 ENOG4108IGT Dipeptidase HC645_RS12175 ENOG4108J2P Alpha beta hydrolase fold HC645_RS12185 ENOG4105E0F Histidine kinase HC645_RS12200 ENOG4105DY8 decarboxylase HC645_RS12205 ENOG4108JPW Aminotransferase HC645_RS12210 ENOG4107Z6I Thiamine biosynthesis protein HC645_RS12215 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HC645_RS12220 ENOG4108YI8 ABC transporter HC645_RS12225 ENOG4105ETU transcriptional activator (TenA HC645_RS12235 ENOG4105CIB oxidoreductase Domain protein HC645_RS12245 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS12250 ENOG4105BZU Histidine kinase HC645_RS12255 ENOG4107QUY Guanine deaminase HC645_RS12260 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HC645_RS12300 ENOG4105CVJ phosphoglycerate mutase HC645_RS12320 ENOG41089BK Glutamine amido-transferase HC645_RS12325 ENOG4105R1U AraC Family Transcriptional Regulator HC645_RS12350 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HC645_RS12375 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HC645_RS12400 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HC645_RS12420 ENOG4105E5Q amino acid AbC transporter HC645_RS12430 ENOG4105C5R Aminotransferase HC645_RS12445 ENOG4105CBN LysR family transcriptional regulator HC645_RS12455 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HC645_RS12460 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HC645_RS12465 ENOG4105CSH Transporter HC645_RS12510 ENOG4105FCD Major Facilitator HC645_RS12520 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS12525 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HC645_RS12535 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HC645_RS12540 ENOG4105UP7 3-epimerase HC645_RS12550 ENOG4108YRF PTS System HC645_RS12555 ENOG4105DM4 PTS System HC645_RS12560 ENOG410829K Lysine exporter protein (Lyse ygga) HC645_RS12570 ENOG4105CBN LysR family transcriptional regulator HC645_RS12575 ENOG4105HEI LysR family (Transcriptional regulator HC645_RS12590 ENOG4107PP3 Acetylornithine deacetylase HC645_RS12605 ENOG4105CNN ABC, transporter HC645_RS12610 ENOG4105C2J ABC transporter HC645_RS12615 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS12645 ENOG4109066 lysm domain bon superfamily protein HC645_RS12650 ENOG4105CXY transporter HC645_RS12655 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HC645_RS12665 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HC645_RS12670 ENOG4105RHY Pfam:UPF0157 HC645_RS12675 ENOG4105EQ2 LysR family Transcriptional regulator HC645_RS12680 ENOG4105CPC Aldo Keto reductase HC645_RS12685 ENOG4107SET aldo keto reductase HC645_RS12690 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis HC645_RS12695 ENOG4105CPC Aldo Keto reductase HC645_RS12740 ENOG4105MQ5 zona occludens toxin HC645_RS12790 ENOG4105ENX hydrolase HC645_RS12805 ENOG4105MVE transcriptional regulator HC645_RS12810 ENOG4105CMG Carbohydrate kinase HC645_RS12815 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HC645_RS12820 ENOG4105E98 transcriptional regulator DeoR family HC645_RS12825 ENOG4105UP7 3-epimerase HC645_RS12830 ENOG4108RVA ribokinase HC645_RS12835 ENOG4105EDR glucose galactose transporter HC645_RS12850 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HC645_RS12855 ENOG4105CHR reductase HC645_RS12860 ENOG4105CHU acetyl-coa acetyltransferase HC645_RS12880 ENOG4105BZW Glycerate kinase HC645_RS12885 ENOG4107VHA regulatoR HC645_RS12895 ENOG4105JQN Transcriptional regulator HC645_RS12905 ENOG4107YCY Transcriptional regulator HC645_RS12910 ENOG4105CI1 PTS System HC645_RS12915 ENOG4105F8D glycoside hydrolase family 4 HC645_RS12925 ENOG4105C54 Major Facilitator superfamily HC645_RS12930 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HC645_RS12950 ENOG4105NIV Esterase HC645_RS12955 ENOG4105BZU Histidine kinase HC645_RS12970 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HC645_RS12985 ENOG4108VCD Chaperone HC645_RS12990 ENOG4105CW0 outer membrane usher protein HC645_RS13000 ENOG4105F32 YngK protein HC645_RS13005 ENOG4105CAF HipA N-terminal domain protein HC645_RS13010 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HC645_RS13015 ENOG4105VT2 5-hydroxyisourate hydrolase HC645_RS13020 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HC645_RS13025 ENOG4105C2W permease HC645_RS13030 ENOG41061H0 Monooxygenase HC645_RS13035 ENOG4108KSA LysR family transcriptional regulator HC645_RS13055 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HC645_RS13070 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HC645_RS13080 ENOG4105D01 (LipO)protein HC645_RS13090 ENOG4108UMI ABC transporter, permease HC645_RS13095 ENOG4105EA8 2-Nitropropane dioxygenase HC645_RS13105 ENOG4105EGI Transcriptional regulator HC645_RS13110 ENOG4105CBP Major Facilitator HC645_RS13120 ENOG4105F9N Major Facilitator Superfamily HC645_RS13150 ENOG4107QZW Altronate oxidoreductase HC645_RS13160 ENOG4105BZU Histidine kinase HC645_RS13165 ENOG4105M0C cytoplasmic protein HC645_RS13170 ENOG4105CSV Glutaminase HC645_RS13175 ENOG4105C26 Dehydrogenase HC645_RS13180 ENOG4105EGI Transcriptional regulator HC645_RS13190 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HC645_RS13195 ENOG4105MVE transcriptional regulator HC645_RS13200 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HC645_RS13205 ENOG4107S2N Type III effector Hrp-dependent HC645_RS13210 ENOG4105C0A alcohol dehydrogenase HC645_RS13215 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HC645_RS13220 ENOG4108JQ1 Dehydrogenase HC645_RS13230 ENOG4105JAB phenazine biosynthesis protein, phzf family HC645_RS13235 ENOG4105F27 Major Facilitator HC645_RS13240 ENOG41082NP Multiple antibiotic resistance HC645_RS13250 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HC645_RS13255 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HC645_RS13260 ENOG4106DNR multiple antibiotic resistance protein HC645_RS13265 ENOG4108594 Permease of the drug metabolite transporter HC645_RS13270 ENOG4105E5W Transporter HC645_RS13280 ENOG4108IV0 ABC, transporter HC645_RS13285 ENOG4105C0Z ABC transporter HC645_RS13290 ENOG4105CNN ABC, transporter HC645_RS13295 ENOG4105C32 Amino acid ABC transporter (Permease) HC645_RS13300 ENOG41083Z3 extracellular ligand-binding receptor HC645_RS13315 ENOG4105ECQ AraC Family Transcriptional Regulator HC645_RS13335 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS13340 ENOG4105CNT hydrolase family 2 HC645_RS13345 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HC645_RS13350 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HC645_RS13365 ENOG4105MVE transcriptional regulator HC645_RS13380 ENOG4105FB2 class II Aldolase HC645_RS13385 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HC645_RS13390 ENOG4105C6Z Gluconate HC645_RS13410 ENOG4105BZU Histidine kinase HC645_RS13415 ENOG4108WTK competence damage-inducible protein HC645_RS13420 ENOG4108ZNX Heat shock protein HC645_RS13455 ENOG4108RAV Conserved protein HC645_RS13460 ENOG4105R1U AraC Family Transcriptional Regulator HC645_RS13470 ENOG4105DGW oligopeptidase A HC645_RS13475 ENOG4105EMU Dehydrogenase HC645_RS13480 ENOG4107XBN GntR Family Transcriptional Regulator HC645_RS13485 ENOG4108U51 Universal stress protein HC645_RS13490 ENOG4105DEI Mannitol dehydrogenase HC645_RS13495 ENOG4108I5G Major Facilitator superfamily HC645_RS13500 ENOG4105KK4 UPF0060 membrane protein HC645_RS13505 ENOG4105M5Q UPF0482 protein HC645_RS13510 ENOG4108MK9 spermidine N(1)-acetyltransferase HC645_RS13520 ENOG4105KBG Protein of unknown function (DUF1161) HC645_RS13525 ENOG4107QY8 reductase HC645_RS13530 ENOG4105QAX Iron-sulfur HC645_RS13535 ENOG4107KGK dmso reductase anchor subunit HC645_RS13540 ENOG4108NEM leader-binding protein dmsD HC645_RS13545 ENOG4105CMQ Chloride channel HC645_RS13550 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HC645_RS13555 ENOG4105DAG ROK family HC645_RS13560 ENOG4106NZI LysR family Transcriptional regulator HC645_RS13565 ENOG4105D94 Major Facilitator Superfamily HC645_RS13570 ENOG4105CTD carboxy-peptidase HC645_RS13590 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HC645_RS13600 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HC645_RS13605 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HC645_RS13610 ENOG4105DSF transport protein HC645_RS13640 ENOG4107TT2 Auxin Efflux Carrier HC645_RS13645 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HC645_RS13650 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HC645_RS13655 ENOG4108K70 Transcriptional regulator HC645_RS13660 ENOG4105DWT malate dehydrogenase (quinone) HC645_RS13665 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HC645_RS13675 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HC645_RS13680 ENOG4108MRH transcriptional regulatory protein HC645_RS13700 ENOG4107GFK fumarate HC645_RS13710 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HC645_RS13715 ENOG4105F2Z 3-oxoadipate enol-lactonase HC645_RS13720 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HC645_RS13725 ENOG4105CHU acetyl-coa acetyltransferase HC645_RS13730 ENOG4107QNJ CoA-transferase subunit B HC645_RS13740 ENOG4107HP6 Transcriptional regulator HC645_RS13745 ENOG4108DG9 Smr protein MutS2 HC645_RS13750 ENOG4106KR7 LysR family Transcriptional regulator HC645_RS13760 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HC645_RS13765 ENOG4105CFC Transporter HC645_RS13775 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HC645_RS13780 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HC645_RS13785 ENOG4105Q9Y Universal stress protein HC645_RS13790 ENOG410671Z uncharacterized protein ydiH HC645_RS13795 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HC645_RS13800 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HC645_RS13815 ENOG4105C5D exported protein HC645_RS13820 ENOG4105D5Q Arginine ornithine antiporter HC645_RS13825 ENOG410642E Short chain dehydrogenase HC645_RS13830 ENOG4105RA2 Membrane HC645_RS13835 ENOG4107EXC regulatoR HC645_RS13845 ENOG4105JJR Histidine kinase HC645_RS13855 ENOG4105C9Q fumarate hydratase class II HC645_RS13860 ENOG4107GFK fumarate HC645_RS13865 ENOG4105EIP mannose-6-phosphate isomerase HC645_RS13870 ENOG4106J39 exported protein HC645_RS13875 ENOG4107P2S Transcriptional regulator HC645_RS13880 ENOG4105CI1 PTS System HC645_RS13885 ENOG4105C87 Aminotransferase class I and II HC645_RS13895 ENOG41061EV selenium-binding protein YdfZ HC645_RS13910 ENOG41066VF YeeE YedE family protein HC645_RS13920 ENOG41064WM Uncharacterized protein YcgX HC645_RS13925 ENOG4105VPI YqaE family transport protein HC645_RS13930 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HC645_RS13935 ENOG4105C26 Dehydrogenase HC645_RS13945 ENOG4107DB1 DUF218 domain HC645_RS13960 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HC645_RS13965 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HC645_RS13970 ENOG4105C26 Dehydrogenase HC645_RS13975 ENOG4105F4X arginine HC645_RS13990 ENOG4105D82 Glutamate dehydrogenase HC645_RS13995 ENOG4105CPC Aldo Keto reductase HC645_RS14000 ENOG410642W LysR family Transcriptional regulator HC645_RS14020 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HC645_RS14030 ENOG4105CQ7 ATP-dependent helicase HC645_RS14035 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HC645_RS14045 ENOG4108Z0R Transferase HC645_RS14050 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HC645_RS14055 ENOG4105DZS Phenylacetate-CoA ligase HC645_RS14060 ENOG4105CHU acetyl-coa acetyltransferase HC645_RS14065 ENOG4108ZJI phenylacetic acid degradation protein HC645_RS14070 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HC645_RS14075 ENOG4108UKI Enoyl-CoA hydratase HC645_RS14080 ENOG4105E39 Enoyl-CoA hydratase HC645_RS14085 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HC645_RS14090 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HC645_RS14095 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HC645_RS14100 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HC645_RS14105 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HC645_RS14110 ENOG4105DXM phenylacetic acid degradation protein HC645_RS14115 ENOG4105F11 amine oxidase HC645_RS14130 ENOG4105CWC Acetylornithine deacetylase HC645_RS14140 ENOG4105KME endoribonuclease L-psp HC645_RS14145 ENOG4105H3G oxidoreductase HC645_RS14150 ENOG4108KB2 LysR family Transcriptional regulator HC645_RS14165 ENOG4105EAB amino acid AbC transporter HC645_RS14180 ENOG4105C26 Dehydrogenase HC645_RS14185 ENOG4108WFR AraC Family Transcriptional Regulator HC645_RS14190 ENOG4105WXT Conserved Protein HC645_RS14195 ENOG410689M (LipO)protein HC645_RS14200 ENOG4107H52 Dicarboxylate transport HC645_RS14205 ENOG4108KF1 Membrane HC645_RS14210 ENOG4105C5I Dehydrogenase HC645_RS14215 ENOG41090X5 Heat shock protein hslJ HC645_RS14220 ENOG4105IKK cytoplasmic protein HC645_RS14225 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HC645_RS14230 ENOG4105FCK Membrane HC645_RS14240 ENOG4108RW8 Universal stress protein F HC645_RS14250 ENOG4105C1J atp-dependent rna helicase HC645_RS14255 ENOG4107RX3 Mg2 transporter protein cora family protein HC645_RS14260 ENOG4105E98 transcriptional regulator DeoR family HC645_RS14265 ENOG4105D9R oxidoreductase HC645_RS14280 ENOG4108UMI ABC transporter, permease HC645_RS14290 ENOG4105D01 (LipO)protein HC645_RS14330 ENOG4105HEI LysR family (Transcriptional regulator HC645_RS14355 ENOG4108XFH Transcriptional regulator HC645_RS14360 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HC645_RS14420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HC645_RS14430 ENOG4108ZG0 Ompa motb domain protein HC645_RS14460 ENOG4108Z0Z intracellular protease Pfpi family HC645_RS14475 ENOG4105CBN LysR family transcriptional regulator HC645_RS14500 ENOG4107RTG Major Facilitator superfamily HC645_RS14505 ENOG4105ENX hydrolase HC645_RS14510 ENOG4105EQ2 LysR family Transcriptional regulator HC645_RS14520 ENOG4107QSI ABC, transporter HC645_RS14530 ENOG4105KXI murein peptide amidase A HC645_RS14535 ENOG4107S8C mandelate racemase muconate lactonizing HC645_RS14540 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HC645_RS14545 ENOG4108KK1 membrane protein AbrB duplication HC645_RS14550 ENOG4108JU8 Transcriptional regulator HC645_RS14555 ENOG4105F8D glycoside hydrolase family 4 HC645_RS14560 ENOG4105W8I Transcriptional regulator HC645_RS14565 ENOG4106K28 UPF0283 membrane protein HC645_RS14570 ENOG4105CM6 amino acid regulated cytosolic protein HC645_RS14575 ENOG4105NNG Peripheral inner membrane phage-shock protein HC645_RS14580 ENOG4105FM1 phage shock protein C HC645_RS14585 ENOG4105YYT phage shock protein B HC645_RS14590 ENOG41087YS Phage shock protein A HC645_RS14595 ENOG4105E51 psp operon transcriptional activator HC645_RS14605 ENOG4105CH2 amidohydrolase HC645_RS14610 ENOG41063ZK Transcriptional Regulator AraC Family HC645_RS14625 ENOG4108J59 Extracellular solute-binding protein, family 5 HC645_RS14630 ENOG4108EKA peptide transport system, permease HC645_RS14635 ENOG4108EU3 peptide transport system, permease HC645_RS14640 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HC645_RS14645 ENOG4108JQ2 peptide transport system atp-binding protein HC645_RS14650 ENOG4105ETS cytosine purines uracil thiamine allantoin HC645_RS14660 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HC645_RS14665 ENOG4105Q4T oxidoreductase HC645_RS14670 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HC645_RS14680 ENOG4105N2W Transcriptional regulator HC645_RS14690 ENOG41061RM osmotically inducible lipoprotein HC645_RS14695 ENOG4108ZJT translation initiation factor, Sui1 HC645_RS14705 ENOG4105CFV Tetratricopeptide repeat protein HC645_RS14710 ENOG4105Q4A inner membrane protein yciS HC645_RS14715 ENOG4105EYK Phosphatidylglycerophosphatase B HC645_RS14720 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HC645_RS14725 ENOG4107QM5 aconitate hydratase HC645_RS14735 ENOG4107R11 Transcriptional regulator HC645_RS14740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HC645_RS14745 ENOG4105RKX Protein of unknown function (DUF2498) HC645_RS14750 ENOG4105ERU peptidase HC645_RS14760 ENOG4105UBK short-chain dehydrogenase reductase HC645_RS14765 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HC645_RS14775 ENOG4105ETT transcriptional Regulator, LysR family HC645_RS14785 ENOG4107RTD sua5 ycio yrdc ywlc family protein HC645_RS14790 ENOG4105DB7 PHP domain protein HC645_RS14795 ENOG4105CRQ synthase (Component I) HC645_RS14800 ENOG4108EFP Anthranilate synthase component II HC645_RS14805 ENOG4105DK0 Indole-3-glycerol phosphate synthase HC645_RS14810 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HC645_RS14815 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HC645_RS14840 ENOG4108IU3 tonb-dependent siderophore receptor HC645_RS14845 ENOG4107E2E PKHD-type hydroxylase HC645_RS14850 ENOG4105EIF outer membrane protein W HC645_RS14855 ENOG4105PI0 Ferredoxin HC645_RS14860 ENOG4108S3I UPF0259 membrane protein HC645_RS14865 ENOG4107835 probably involved in intracellular septation (By similarity) HC645_RS14870 ENOG4107RNH Outer membrane receptor FepA HC645_RS14875 ENOG4105NAU thioesterase Superfamily protein HC645_RS14880 ENOG4107PN8 YfeABCD locus regulator HC645_RS14885 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HC645_RS14890 ENOG4105CHR reductase HC645_RS14895 ENOG4107K5X Membrane-bound metal-dependent hydrolase HC645_RS14900 ENOG4108ETY sodium dicarboxylate symporter HC645_RS14905 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HC645_RS14910 ENOG4105CH6 catalase HC645_RS14915 ENOG410901P UPF0249 protein HC645_RS14920 ENOG4105F8D glycoside hydrolase family 4 HC645_RS14925 ENOG4105EZV Transcriptional regulator HC645_RS14930 ENOG4105VCP PTS System HC645_RS14935 ENOG4105CK1 PTS System HC645_RS14945 ENOG4105VZJ PTS System HC645_RS14950 ENOG4105KKI DNA-binding transcriptional activator OsmE HC645_RS14960 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HC645_RS14965 ENOG4108SPG Periplasmic Protein HC645_RS14975 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HC645_RS14980 ENOG4105C26 Dehydrogenase HC645_RS14985 ENOG4105F4X arginine HC645_RS14995 ENOG4105CGK Exodeoxyribonuclease III HC645_RS15000 ENOG4108RSN SNARE associated Golgi HC645_RS15005 ENOG4108N5C SNARE associated Golgi protein-related protein HC645_RS15010 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HC645_RS15015 ENOG4105VNH ABC transporter solute-binding protein HC645_RS15020 ENOG4105CXZ ABC transporter, permease HC645_RS15025 ENOG4108VGW abc transporter atp-binding protein HC645_RS15030 ENOG4107RM6 sulfurtransferase HC645_RS15035 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HC645_RS15040 ENOG4105M6F mutator MutT protein HC645_RS15045 ENOG4105D82 Glutamate dehydrogenase HC645_RS15055 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HC645_RS15060 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HC645_RS15065 ENOG4105SBG acid phosphatase HC645_RS15070 ENOG41069NU Nitroreductase HC645_RS15075 ENOG4105D07 Signal peptide peptidase, SppA HC645_RS15080 ENOG4105HDK L-asparaginase HC645_RS15085 ENOG4108RWI nicotinamidase HC645_RS15090 ENOG4108KUU Inner membrane metabolite transport protein ydjE HC645_RS15095 ENOG4105E98 transcriptional regulator DeoR family HC645_RS15100 ENOG4105CPC Aldo Keto reductase HC645_RS15105 ENOG4107UH8 sugar kinase HC645_RS15110 ENOG4105D2N Aldolase HC645_RS15115 ENOG4105CPQ Dehydrogenase HC645_RS15120 ENOG4107TE1 transport protein HC645_RS15125 ENOG4105CPQ Dehydrogenase HC645_RS15135 ENOG4105N1F Hnh endonuclease HC645_RS15140 ENOG4105VUT cytoplasmic protein HC645_RS15145 ENOG4105E0X reductase HC645_RS15150 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HC645_RS15155 ENOG4105DSB aldose 1-epimerase HC645_RS15160 ENOG4105CV8 reductase HC645_RS15165 ENOG4105GNX MltA-interacting MipA family protein HC645_RS15170 ENOG4105CYN Serine protein kinase HC645_RS15175 ENOG4106AKX UPF0229 protein HC645_RS15185 ENOG4108V06 Glutathione peroxidase HC645_RS15210 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HC645_RS15215 ENOG4105CBN LysR family transcriptional regulator HC645_RS15220 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC645_RS15225 ENOG4105KT5 UmuD protein HC645_RS15230 ENOG4105Y50 Virulence Protein HC645_RS15235 ENOG4108XNZ glycosyl transferase HC645_RS15240 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HC645_RS15245 ENOG4108VMM UPF0756 membrane protein HC645_RS15250 ENOG4105R1U AraC Family Transcriptional Regulator HC645_RS15255 ENOG4105DJ2 Major Facilitator Superfamily HC645_RS15260 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HC645_RS15265 ENOG4105EWC Purine nucleoside phosphorylase HC645_RS15270 ENOG4105K78 MarR family Transcriptional regulator HC645_RS15275 ENOG4105UCG Domain of unknown function (DUF333) HC645_RS15280 ENOG410620I Diguanylate cyclase HC645_RS15285 ENOG4106G4W HC645_RS15300 ENOG4105S5I Membrane HC645_RS15305 ENOG4108NIW Leucine export protein LeuE HC645_RS15310 ENOG4105D1S lipid A biosynthesis HC645_RS15325 ENOG4105DHT Metal Dependent Phosphohydrolase HC645_RS15330 ENOG4106TD9 Diguanylate cyclase HC645_RS15335 ENOG4107RSM transcriptional regulator HC645_RS15340 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HC645_RS15370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HC645_RS15375 ENOG4105C4M (Ubiquinol oxidase) subunit I HC645_RS15380 ENOG4105WEF catalase HC645_RS15385 ENOG4108N8X transition metal ion binding HC645_RS15390 ENOG4108Z9Z response to DNA damage stimulus HC645_RS15405 ENOG4105E2A Dehydrogenase HC645_RS15410 ENOG4105XDF Protein of unknown function (DUF1272) HC645_RS15435 ENOG4108ZHR arsR family transcriptional regulator HC645_RS15440 ENOG4108HMX isocitrate dehydrogenase (NADP) HC645_RS15455 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HC645_RS15460 ENOG41075W9 High frequency lysogenization protein HflD homolog HC645_RS15465 ENOG4107QTF adenylosuccinate lyase HC645_RS15485 ENOG4105IFJ Histidine kinase HC645_RS15490 ENOG4105EZE Cupin 4 family protein HC645_RS15510 ENOG4105D38 putrescine abc transporter HC645_RS15515 ENOG4108HM4 ABC transporter HC645_RS15525 ENOG4105CEY Amp-dependent synthetase and ligase HC645_RS15530 ENOG4105CV1 Transketolase (EC 2.2.1.1) HC645_RS15535 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HC645_RS15540 ENOG4108YZG isomerase HC645_RS15545 ENOG4105VI0 Pts system, glucitol sorbitol-specific HC645_RS15550 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HC645_RS15555 ENOG4105G63 Type III effector Hrp-dependent HC645_RS15570 ENOG4105DKT Transcriptional regulator HC645_RS15580 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HC645_RS15585 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HC645_RS15590 ENOG4105D60 lipoprotein releasing system transmembrane protein HC645_RS15595 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HC645_RS15600 ENOG4105D60 lipoprotein releasing system transmembrane protein HC645_RS15610 ENOG4108JA2 transcriptioN-repair coupling factor HC645_RS15615 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HC645_RS15620 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HC645_RS15630 ENOG4108IND Tetr family transcriptional regulator HC645_RS15645 ENOG4107MBR 17 kDa surface antigen HC645_RS15650 ENOG4105CEP NADH dehydrogenase HC645_RS15655 ENOG4105D0Y UPF0227 protein HC645_RS15670 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HC645_RS15675 ENOG41090DQ Lipoprotein HC645_RS15680 ENOG4105K59 histidine triad (HIT) protein HC645_RS15685 ENOG4105CI1 PTS System HC645_RS15690 ENOG4105F8V Hydrolase, tatD family HC645_RS15695 ENOG4107QRG dna polymerase iii HC645_RS15700 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HC645_RS15705 ENOG4105HHA aminodeoxychorismate lyase HC645_RS15710 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HC645_RS15715 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HC645_RS15720 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HC645_RS15725 ENOG4105CHR reductase HC645_RS15730 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HC645_RS15735 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HC645_RS15740 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HC645_RS15745 ENOG4105VGS 50s ribosomal protein l32 HC645_RS15750 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HC645_RS15755 ENOG4108UHJ MAF-like protein HC645_RS15760 ENOG4105EI2 Pseudouridine synthase HC645_RS15770 ENOG4107QQB Ribonuclease E HC645_RS15775 ENOG4105CR8 Transcriptional regulator HC645_RS15780 ENOG4105EQ0 Major Facilitator superfamily HC645_RS15785 ENOG4105CJR Integral membrane protein (MviN HC645_RS15790 ENOG4105EP9 oxidoreductase HC645_RS15795 ENOG4108YXG UPF0502 protein HC645_RS15800 ENOG4105D9U N-acetyltransferase HC645_RS15805 ENOG4105EV4 Multidrug resistance protein mdtH HC645_RS15810 ENOG4105F3T (LipO)protein HC645_RS15815 ENOG4105EKE dihydroorotase HC645_RS15820 ENOG4105MEA DNA damage-inducible protein i HC645_RS15825 ENOG4105PVA Biofilm formation regulatory protein BssS HC645_RS15835 ENOG4106974 biofilm formation HC645_RS15850 ENOG4105D1S lipid A biosynthesis HC645_RS15860 ENOG4108W47 Acidic protein msyB HC645_RS15865 ENOG4105NAC (LipO)protein HC645_RS15870 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HC645_RS15880 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HC645_RS15895 ENOG4108UQ5 membrane protein YcdZ HC645_RS15900 ENOG4107XHZ cytoplasmic chaperone TorD family protein HC645_RS15910 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HC645_RS15925 ENOG4105HEI LysR family (Transcriptional regulator HC645_RS15930 ENOG4105EUB pirin domain protein HC645_RS15935 ENOG4105CHJ isochorismatase hydrolase HC645_RS15950 ENOG4105D5M phosphate starvation-inducible protein HC645_RS15955 ENOG4105DBE peroxidase HC645_RS15960 ENOG410650H (LipO)protein HC645_RS15970 ENOG4105D9N nucleoside HC645_RS15985 ENOG4105CK7 Sodium proline symporter HC645_RS15990 ENOG4105C26 Dehydrogenase HC645_RS16000 ENOG4108R86 Transcriptional regulator HC645_RS16005 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HC645_RS16015 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HC645_RS16020 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HC645_RS16025 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HC645_RS16030 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HC645_RS16035 ENOG4105C2W permease HC645_RS16045 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HC645_RS16060 ENOG4105XH3 HC645_RS16065 ENOG4105D6F Phosphatase HC645_RS16075 ENOG4105CHR reductase HC645_RS16090 ENOG4105CUB amino acid HC645_RS16095 ENOG4105CFQ glutamine synthetase HC645_RS16100 ENOG4108Z86 Glutamine amidotransferase HC645_RS16105 ENOG4107VRI Transcriptional regulator HC645_RS16110 ENOG4105C26 Dehydrogenase HC645_RS16115 ENOG4105CJP fad dependent oxidoreductase HC645_RS16120 ENOG4105EJC lysr family transcriptional regulator HC645_RS16125 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HC645_RS16130 ENOG4105C94 Transporter HC645_RS16135 ENOG4105DVW rieske (2Fe-2S) HC645_RS16140 ENOG4105C26 Dehydrogenase HC645_RS16145 ENOG4105E3J oxidoreductase HC645_RS16165 ENOG4107QSI ABC, transporter HC645_RS16170 ENOG4108MN8 Membrane HC645_RS16180 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HC645_RS16185 ENOG4108UQN AraC family transcriptional regulator HC645_RS16190 ENOG4108V1U phospholipid-binding protein HC645_RS16195 ENOG4105DR4 Methyltransferase HC645_RS16200 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HC645_RS16205 ENOG4105K4P CoA-binding domain protein HC645_RS16215 ENOG41088T4 Helicase IV HC645_RS16220 ENOG410901E Membrane HC645_RS16225 ENOG4105EM2 membrane HC645_RS16230 ENOG4108RZ1 DNA transformation protein HC645_RS16235 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HC645_RS16240 ENOG4105UYK outer membrane protein a HC645_RS16245 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HC645_RS16250 ENOG4105DAN ATP-dependent protease HC645_RS16255 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HC645_RS16260 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HC645_RS16265 ENOG4108Q2G (LipO)protein HC645_RS16270 ENOG4105DY2 Paraquat-inducible protein b HC645_RS16275 ENOG4105F1S paraquat-inducible protein a HC645_RS16280 ENOG4105C5H ABC transporter HC645_RS16285 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HC645_RS16290 ENOG4105QVC MOSC domain-containing protein HC645_RS16295 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HC645_RS16305 ENOG4108UZX fmn reductase HC645_RS16310 ENOG4105GVF (ABC) transporter HC645_RS16315 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HC645_RS16320 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HC645_RS16330 ENOG4105CD8 aminopeptidase N HC645_RS16335 ENOG4107RH7 Nicotinate phosphoribosyltransferase HC645_RS16340 ENOG4105CH2 amidohydrolase HC645_RS16345 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HC645_RS16350 ENOG4105C44 Serine transporter HC645_RS16355 ENOG4107RCH Diaminopropionate ammonia-lyase HC645_RS16365 ENOG4105C5S asparaginyl-tRNA synthetase HC645_RS16370 ENOG4105ZIT Porin Gram-negative type HC645_RS16375 ENOG4105CGF Aromatic amino acid aminotransferase HC645_RS16380 ENOG4105C5X domain protein HC645_RS16385 ENOG4105EAQ (twin-arginine translocation) pathway signal HC645_RS16390 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HC645_RS16395 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HC645_RS16400 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HC645_RS16405 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HC645_RS16410 ENOG4106371 Methyltransferase HC645_RS16415 ENOG4107S90 membrAne HC645_RS16420 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HC645_RS16425 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HC645_RS16430 ENOG4105W49 UPF0434 protein HC645_RS16435 ENOG4105T0Z Conserved Protein HC645_RS16440 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HC645_RS16445 ENOG4105BZ1 (ABC) transporter HC645_RS16450 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HC645_RS16455 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HC645_RS16460 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HC645_RS16465 ENOG4105CAT Cytidine monophosphate kinase HC645_RS16470 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HC645_RS16475 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HC645_RS16480 ENOG4107VMU Membrane HC645_RS16485 ENOG4105DDY UPF0142 protein ycaO HC645_RS16490 ENOG4105TMB Formate nitrite transporter HC645_RS16495 ENOG4105C6N Formate acetyltransferase HC645_RS16500 ENOG4105F1A Pyruvate formate-lyase HC645_RS16505 ENOG4108ISG Major Facilitator HC645_RS16515 ENOG4107KGK dmso reductase anchor subunit HC645_RS16520 ENOG4105QAX Iron-sulfur HC645_RS16525 ENOG4107QY8 reductase HC645_RS16530 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HC645_RS16535 ENOG4105D1H recombination factor protein RarA HC645_RS16540 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HC645_RS16545 ENOG4105CNU cell division protein FtsK HC645_RS16550 ENOG4105EW9 transcriptional regulator AsnC family HC645_RS16560 ENOG4105C3M thioredoxin reductase HC645_RS16565 ENOG4108JJ9 ABC, transporter HC645_RS16570 ENOG4108JJ8 (ABC) transporter HC645_RS16575 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HC645_RS16580 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HC645_RS16585 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HC645_RS16590 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HC645_RS16595 ENOG4105VEQ Cold shock protein HC645_RS16605 ENOG4105DJY efflux transporter, rnd family, mfp subunit HC645_RS16610 ENOG4105CPB ATP-dependent endonuclease of the OLD family HC645_RS16615 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HC645_RS16620 ENOG4105DWU Membrane HC645_RS16630 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HC645_RS16640 ENOG4105C7K acetolactate synthase HC645_RS16645 ENOG4105C5W Aldolase HC645_RS16650 ENOG4105CGD Nad-dependent epimerase dehydratase HC645_RS16655 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HC645_RS16660 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HC645_RS16670 ENOG41064MM (LipO)protein HC645_RS16675 ENOG4105E5Z arginine transporter ATP-binding subunit HC645_RS16680 ENOG4106PMH Extracellular solute-binding protein family 3 HC645_RS16685 ENOG4105GBT ABC transporter HC645_RS16690 ENOG4105DMR ABC, transporter HC645_RS16695 ENOG4106TNF Periplasmic binding protein HC645_RS16700 ENOG4105BZU Histidine kinase HC645_RS16705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC645_RS16710 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HC645_RS16715 ENOG4105RBQ inner membrane protein ybjO HC645_RS16720 ENOG4105D38 putrescine abc transporter HC645_RS16725 ENOG4105F38 ABC transporter, permease HC645_RS16730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HC645_RS16735 ENOG4107RUE extracellular solute-binding protein family 1 HC645_RS16740 ENOG4108RMJ sensory transduction regulator HC645_RS16750 ENOG4108DBC nitroreductase HC645_RS16755 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HC645_RS16760 ENOG41090BQ Glutaredoxin HC645_RS16765 ENOG4105GWF inner membrane protein YbjM HC645_RS16780 ENOG4108RFG Tetr family transcriptional regulator HC645_RS16785 ENOG4106UW1 Major Facilitator superfamily HC645_RS16790 ENOG4108HCJ Hydrolase HC645_RS16795 ENOG4107QF7 multi-drug HC645_RS16800 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HC645_RS16805 ENOG4107FB0 transcriptional regulator DeoR family HC645_RS16810 ENOG4105DZ1 carboxypeptidase HC645_RS16820 ENOG4108TGY Glutathione S-transferase HC645_RS16825 ENOG4105D8V Glucose sorbosone dehydrogenase HC645_RS16830 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HC645_RS16835 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HC645_RS16840 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HC645_RS16845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS16850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC645_RS16855 ENOG4105DEF Extracellular solute-binding protein, family 5 HC645_RS16860 ENOG4108JQ6 ABC transporter HC645_RS16865 ENOG4105D44 asparaginase HC645_RS16870 ENOG4105CVM Molybdenum cofactor synthesis domain protein HC645_RS16875 ENOG4105D06 uba thif-type nad fad binding protein HC645_RS16880 ENOG4105F1A Pyruvate formate-lyase HC645_RS16890 ENOG4108HCJ Hydrolase HC645_RS16895 ENOG41072TH Protein of unknown function (DUF1479) HC645_RS16900 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS16905 ENOG4105DPW Major facilitator superfamily MFS_1 HC645_RS16915 ENOG4105C5H ABC transporter HC645_RS16920 ENOG4105M2Z protein tyrosine serine phosphatase HC645_RS16925 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HC645_RS16930 ENOG4108TZY GntR Family Transcriptional Regulator HC645_RS16935 ENOG4105CS2 ec 3.2.1.21 HC645_RS16940 ENOG4105F4P )-transporter HC645_RS16945 ENOG4105KST dependent repressor HC645_RS16955 ENOG4108I6E Sulfatase HC645_RS16960 ENOG4108T1M outer membrane protein x HC645_RS16975 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HC645_RS16980 ENOG4107R0W ABC transporter HC645_RS16985 ENOG4105E5Q amino acid AbC transporter HC645_RS16990 ENOG4105CDA abc transporter atp-binding protein HC645_RS16995 ENOG4105D8X mechanosensitive ion channel HC645_RS17000 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HC645_RS17005 ENOG4105EW6 flavin reductase domain protein, FMN-binding HC645_RS17015 ENOG4105KSC Transcriptional regulator, TraR DksA family HC645_RS17020 ENOG4105VR4 UPF0379 protein ybiJ HC645_RS17025 ENOG4108MTB glycosyl transferase family HC645_RS17030 ENOG4105DVT helicase HC645_RS17035 ENOG4105C1J atp-dependent rna helicase HC645_RS17055 ENOG4105DJB Major Facilitator Superfamily HC645_RS17065 ENOG4105ETT transcriptional Regulator, LysR family HC645_RS17070 ENOG4107MVR Transcriptional regulator HC645_RS17075 ENOG4105D0S secretion protein (HlyD HC645_RS17080 ENOG4105CJ1 ABC, transporter HC645_RS17085 ENOG4107QWP ABC-2 type transporter HC645_RS17090 ENOG4107QWP ABC-2 type transporter HC645_RS17095 ENOG4105I9U inner membrane protein ybhQ HC645_RS17100 ENOG4105X23 Endonuclease Exonuclease phosphatase HC645_RS17105 ENOG4105DZQ phospholipase D Transphosphatidylase HC645_RS17110 ENOG4107UXM Membrane HC645_RS17115 ENOG4105HFZ Membrane HC645_RS17120 ENOG4108ZAF Molybdopterin HC645_RS17125 ENOG4105M00 molybdopterin converting factor, subunit 1 HC645_RS17130 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HC645_RS17135 ENOG4108RIR Molybdenum cofactor biosynthesis protein HC645_RS17140 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HC645_RS17145 ENOG4105CHW UPF0052 protein HC645_RS17150 ENOG4105DIJ Phosphoethanolamine transferase HC645_RS17155 ENOG4105XJC Two component transcriptional regulator (Winged helix family HC645_RS17160 ENOG4105ECM Sensor protein basS pmrB HC645_RS17165 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HC645_RS17175 ENOG4108IV0 ABC, transporter HC645_RS17185 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HC645_RS17190 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HC645_RS17195 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HC645_RS17200 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC645_RS17205 ENOG4108V1U phospholipid-binding protein HC645_RS17210 ENOG4105C85 amino acid HC645_RS17215 ENOG4105C84 Histidine ammonia-lyase HC645_RS17220 ENOG4105CGP Urocanate hydratase HC645_RS17235 ENOG41088SP formiminoglutamate hydrolase HC645_RS17240 ENOG4105CI2 imidazolone-5-propionate hydrolase HC645_RS17245 ENOG4105NBR Pectinesterase HC645_RS17255 ENOG4108U51 Universal stress protein HC645_RS17260 ENOG4105ENT Efflux transporter rnd family, mfp subunit HC645_RS17295 ENOG4108XDN Transcriptional regulator HC645_RS17300 ENOG4105BZU Histidine kinase HC645_RS17305 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HC645_RS17320 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HC645_RS17325 ENOG4108K4B hydrolase HC645_RS17335 ENOG4105E0C molybdate abc transporter HC645_RS17340 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HC645_RS17350 ENOG4105F4R Transcriptional regulator mode HC645_RS17360 ENOG4105DKW ABC transporter HC645_RS17365 ENOG4105CMR udp-glucose 4-epimerase HC645_RS17370 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HC645_RS17375 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HC645_RS17380 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HC645_RS17385 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HC645_RS17390 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HC645_RS17395 ENOG4105JND homeobox protein HC645_RS17400 ENOG4105PGM cation diffusion facilitator family transporter HC645_RS17405 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HC645_RS17410 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HC645_RS17465 ENOG4105UFD tol-pal system protein YbgF HC645_RS17470 ENOG4105KCK Peptidoglycan-associated lipoprotein HC645_RS17480 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HC645_RS17490 ENOG4105E02 MotA TolQ exbB proton channel HC645_RS17495 ENOG4107YD3 Thioesterase HC645_RS17500 ENOG4105KJB cyd operon protein YbgE HC645_RS17510 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HC645_RS17515 ENOG4105C4M (Ubiquinol oxidase) subunit I HC645_RS17525 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HC645_RS17530 ENOG4105CMV Succinyl-CoA synthetase subunit beta HC645_RS17535 ENOG4105C7S Dehydrogenase HC645_RS17540 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HC645_RS17545 ENOG4105E33 succinate dehydrogenase HC645_RS17550 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HC645_RS17555 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HC645_RS17560 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HC645_RS17565 ENOG4105BZN citrate synthase HC645_RS17570 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HC645_RS17590 ENOG4105E7W lamb ycsf family protein HC645_RS17595 ENOG4107R7A Allophanate hydrolase subunit 2 HC645_RS17600 ENOG4105P4J Allophanate hydrolase, subunit 1 HC645_RS17605 ENOG4107QNR UPF0135 protein HC645_RS17610 ENOG4105DUX Transporter HC645_RS17615 ENOG4105CVP deoxyribo-dipyrimidine photolyase HC645_RS17620 ENOG4105XIQ Protein of unknown function (DUF2517) HC645_RS17630 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HC645_RS17635 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HC645_RS17640 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HC645_RS17645 ENOG4105C08 Histidine kinase HC645_RS17650 ENOG4105EEX Two component transcriptional regulator (Winged helix family HC645_RS17660 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HC645_RS17665 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HC645_RS17670 ENOG4105EV9 Alpha Beta Hydrolase HC645_RS17675 ENOG4105NNH LexA regulated protein HC645_RS17680 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HC645_RS17685 ENOG41090R7 Ferric uptake HC645_RS17690 ENOG4105CSH Transporter HC645_RS17695 ENOG4105GX6 (LipO)protein HC645_RS17700 ENOG4105J5J Outer membrane porin HC645_RS17710 ENOG4105CX6 glutaminyL-tRNA synthetase HC645_RS17715 ENOG4105CI1 PTS System HC645_RS17720 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HC645_RS17725 ENOG4105CE4 GlcNAc 6-P deacetylase HC645_RS17730 ENOG4105E2R ROK family HC645_RS17735 ENOG4105D4U had-superfamily hydrolase, subfamily iia HC645_RS17740 ENOG4105CAQ asparagine synthetase HC645_RS17780 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HC645_RS17785 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HC645_RS17790 ENOG4105C9A Phoh family HC645_RS17795 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HC645_RS17800 ENOG4108JU5 Magnesium and cobalt efflux protein HC645_RS17805 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HC645_RS17810 ENOG4107RP9 extracellular solute-binding protein, family 3 HC645_RS17815 ENOG4105EAD ABC transporter HC645_RS17820 ENOG4105DRP amino acid AbC transporter HC645_RS17825 ENOG4105CDA abc transporter atp-binding protein HC645_RS17840 ENOG4107PAI alpha helical protein HC645_RS17845 ENOG4105C8T Leucyl-tRNA synthetase HC645_RS17855 ENOG4105DJF DNA polymerase III, delta' subunit HC645_RS17860 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HC645_RS17865 ENOG4108TGR phosphatase HC645_RS17870 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HC645_RS17875 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HC645_RS17880 ENOG4105CJN penicillin-binding protein HC645_RS17885 ENOG4105CNI cell division protein FtsW HC645_RS17890 ENOG4105K6T rare lipoprotein A HC645_RS17895 ENOG4105DZ1 carboxypeptidase HC645_RS17900 ENOG4108Z43 UPF0250 protein HC645_RS17905 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HC645_RS17910 ENOG41064T2 transcriptional regulator, lysR family HC645_RS17915 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HC645_RS17920 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HC645_RS17940 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HC645_RS17945 ENOG4105CEE C4-dicarboxylate transporter HC645_RS17950 ENOG4105KTS ribonuclease HC645_RS17955 ENOG4105NXH GreA GreB family elongation factor HC645_RS17960 ENOG4108U51 Universal stress protein HC645_RS17965 ENOG4108JU3 Alkyl hydroperoxide reductase HC645_RS17970 ENOG4105D3R alkyl hydroperoxide reductase HC645_RS17975 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HC645_RS17980 ENOG4105DQS Transcriptional regulator HC645_RS17985 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HC645_RS17990 ENOG4105GTN ParB Domain Protein Nuclease HC645_RS17995 ENOG4105CHM Aminotransferase HC645_RS18000 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HC645_RS18005 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HC645_RS18020 ENOG4105C2J ABC transporter HC645_RS18030 ENOG4105CNN ABC, transporter HC645_RS18040 ENOG4108M3J Dehydrogenase HC645_RS18050 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HC645_RS18055 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HC645_RS18065 ENOG4105DZC cytosine deaminase HC645_RS18075 ENOG4105ECY inositol monophosphatase HC645_RS18080 ENOG4105CXY transporter HC645_RS18085 ENOG4105D6F Phosphatase HC645_RS18090 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HC645_RS18095 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HC645_RS18115 ENOG4105CNN ABC, transporter HC645_RS18120 ENOG4105C2J ABC transporter HC645_RS18125 ENOG4107SCQ Iron-containing alcohol dehydrogenase HC645_RS18130 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HC645_RS18155 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HC645_RS18165 ENOG4105FDP GntR family transcriptional regulator HC645_RS18175 ENOG4108RVA ribokinase HC645_RS18190 ENOG4105CT4 transporter HC645_RS18195 ENOG4105VCD cytoplasmic protein HC645_RS18200 ENOG4105D22 carbon starvation protein HC645_RS18205 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HC645_RS18210 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HC645_RS18215 ENOG4105WQI isochorismatase HC645_RS18220 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HC645_RS18225 ENOG4105E4F Isochorismate synthase HC645_RS18230 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HC645_RS18235 ENOG4105E8G Major facilitator Superfamily HC645_RS18240 ENOG4105DQ5 transport system permease protein HC645_RS18245 ENOG4105TVJ transport system, permease HC645_RS18250 ENOG4105E0A ABC, transporter HC645_RS18255 ENOG4105C0W non-ribosomal peptide synthetase HC645_RS18260 ENOG41085A6 mbth domain-containing protein HC645_RS18265 ENOG4105E93 esterase HC645_RS18270 ENOG4107RNH Outer membrane receptor FepA HC645_RS18275 ENOG4108TSE Transferase HC645_RS18280 ENOG4108IUS Transketolase HC645_RS18285 ENOG4108HHA Transketolase HC645_RS18290 ENOG4105DKT Transcriptional regulator HC645_RS18295 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HC645_RS18300 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HC645_RS18310 ENOG4105C2J ABC transporter HC645_RS18315 ENOG4105CNN ABC, transporter HC645_RS18325 ENOG4108R85 Short chain dehydrogenase HC645_RS18335 ENOG410810E transcriptional regulator, lysR family HC645_RS18340 ENOG4105CUY Mechanosensitive ion channel HC645_RS18345 ENOG4108WN0 inhibitor of vertebrate lysozyme HC645_RS18350 ENOG4105C94 Transporter HC645_RS18365 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HC645_RS18375 ENOG4105DEF Extracellular solute-binding protein, family 5 HC645_RS18380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC645_RS18385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS18390 ENOG4105C3U ABC transporter HC645_RS18395 ENOG4108JQ7 (ABC) transporter HC645_RS18400 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC645_RS18405 ENOG4105EMU Dehydrogenase HC645_RS18415 ENOG4105GBT ABC transporter HC645_RS18420 ENOG4105DRP amino acid AbC transporter HC645_RS18425 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HC645_RS18435 ENOG4105CHM Aminotransferase HC645_RS18440 ENOG4105T38 integral membrane protein HC645_RS18445 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HC645_RS18460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC645_RS18470 ENOG4108J59 Extracellular solute-binding protein, family 5 HC645_RS18475 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HC645_RS18480 ENOG4108T58 Mg2 transport protein CorA HC645_RS18505 ENOG4105WQ6 Membrane HC645_RS18510 ENOG4105HFT AraC family transcriptional regulator HC645_RS18520 ENOG410630P Transcriptional regulator HC645_RS18525 ENOG4105MSB protein, conserved in bacteria HC645_RS18530 ENOG4108RCM Nitroreductase HC645_RS18540 ENOG4108IQ3 PTS system HC645_RS18550 ENOG4105F3R pts system mannose fructose sorbose family iid HC645_RS18555 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HC645_RS18560 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HC645_RS18565 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HC645_RS18585 ENOG4105CUY Mechanosensitive ion channel HC645_RS18590 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS18600 ENOG4105CK5 oxidoreductase HC645_RS18610 ENOG4105EAA nucleoside HC645_RS18615 ENOG4105C85 amino acid HC645_RS18625 ENOG4108NS2 receptor HC645_RS18630 ENOG4105C26 Dehydrogenase HC645_RS18635 ENOG4105CJP fad dependent oxidoreductase HC645_RS18645 ENOG4105CUB amino acid HC645_RS18655 ENOG4105DGU Histone deacetylase HC645_RS18665 ENOG4108UAJ Transcriptional regulator HC645_RS18675 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HC645_RS18690 ENOG4105CPC Aldo Keto reductase HC645_RS18695 ENOG4105E89 ABC transporter HC645_RS18700 ENOG4105CH2 amidohydrolase HC645_RS18735 ENOG4105EHG Permease protein HC645_RS18740 ENOG4105E0A ABC, transporter HC645_RS18745 ENOG4105EFX secretion protein, HlyD family HC645_RS18750 ENOG4105KK7 inner membrane protein YiaW HC645_RS18765 ENOG4105D7K pfkb domain protein HC645_RS18770 ENOG4108M0B Sucrose porin HC645_RS18775 ENOG4105C5Y PTS System HC645_RS18780 ENOG4108HKT sucrose-6-phosphate hydrolase HC645_RS18785 ENOG4105WBN Transcriptional regulator (LacI family HC645_RS18800 ENOG4108HWV )-transporter HC645_RS18805 ENOG4105C2J ABC transporter HC645_RS18845 ENOG4105CRK lysyL-tRNA synthetase HC645_RS18850 ENOG4105DUX Transporter HC645_RS18855 ENOG4105CXN decarboxylase HC645_RS18860 ENOG4105D5Q Arginine ornithine antiporter HC645_RS18865 ENOG4108M3R transcriptional activator CadC HC645_RS18875 ENOG4105D1S lipid A biosynthesis HC645_RS18890 ENOG4105CW0 outer membrane usher protein HC645_RS18895 ENOG4105GQR Chaperone HC645_RS18900 ENOG4105X0I Fimbrial HC645_RS18915 ENOG4105BZN citrate synthase HC645_RS18945 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HC645_RS18950 ENOG4105WQ3 Rna-binding protein HC645_RS18955 ENOG4105C8N cysteinyl-tRNA synthetase HC645_RS18960 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HC645_RS18965 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HC645_RS18975 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HC645_RS18980 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HC645_RS19000 ENOG4105CV6 ABC transporter, permease HC645_RS19005 ENOG4108I0Y (ABC) transporter HC645_RS19010 ENOG4108UJV acyl-CoA thioesterase i HC645_RS19015 ENOG4105E1F short-chain dehydrogenase reductase HC645_RS19020 ENOG4107QR8 Thioredoxin HC645_RS19025 ENOG4105C4B ABC transporter, permease HC645_RS19030 ENOG41083J0 (ABC) transporter HC645_RS19035 ENOG4107QX8 SPFH domain, Band 7 family protein HC645_RS19040 ENOG4105G5H Membrane HC645_RS19045 ENOG4108Z6Z Transcriptional regulator HC645_RS19050 ENOG4105C59 p-type ATPase HC645_RS19055 ENOG4105MBR gumn family HC645_RS19060 ENOG4108Z66 YbaK ebsC protein HC645_RS19065 ENOG4105CGH 5'-nucleotidase HC645_RS19070 ENOG4105EU0 Major facilitator Superfamily HC645_RS19085 ENOG4105CKD glutathione-regulated potassium-efflux system protein HC645_RS19090 ENOG4107RE1 Inosine-guanosine kinase HC645_RS19100 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HC645_RS19105 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HC645_RS19110 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HC645_RS19115 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HC645_RS19120 ENOG4107QMP dna polymerase iii subunits gamma and tau HC645_RS19125 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HC645_RS19130 ENOG4105WD1 Membrane HC645_RS19135 ENOG4108URS primosomal replication protein n'' HC645_RS19140 ENOG4106428 Protein of unknown function (DUF2496) HC645_RS19145 ENOG4105DNE Transposase HC645_RS19150 ENOG4105EGS Mechanosensitive ion channel HC645_RS19155 ENOG4107XI7 Tetr family transcriptional regulator HC645_RS19160 ENOG4105C1P efflux transporter, rnd family, mfp subunit HC645_RS19165 ENOG4105BZS acriflavin resistance protein HC645_RS19170 ENOG4108UKR Biofilm formation regulator YbaJ HC645_RS19180 ENOG4108UW5 maltose o-acetyltransferase HC645_RS19190 ENOG4105GSJ Inner membrane protein ylaC HC645_RS19205 ENOG4105YK5 50S ribosomal protein L36 HC645_RS19215 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS19220 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HC645_RS19225 ENOG4105CI1 PTS System HC645_RS19230 ENOG4105C4C beta-galactosidase HC645_RS19240 ENOG4105EG2 ABC transporter, permease HC645_RS19250 ENOG4107FKK extracellular solute-binding protein family 1 HC645_RS19265 ENOG41066DG (EAL) domain protein HC645_RS19270 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HC645_RS19275 ENOG41061MD high-affinity nickel-transporter HC645_RS19280 ENOG4108VW9 Membrane HC645_RS19310 ENOG41080UX Methyltransferase HC645_RS19315 ENOG4108MNP Glycoprotein polysaccharide metabolism HC645_RS19320 ENOG4105C29 acyl-CoA thioesterase HC645_RS19325 ENOG4105BZU Histidine kinase HC645_RS19330 ENOG4108YZA Nitrogen regulatory protein pii HC645_RS19335 ENOG4105BZ1 (ABC) transporter HC645_RS19340 ENOG4105BZ1 (ABC) transporter HC645_RS19345 ENOG4108XM1 transcriptional regulator AsnC family HC645_RS19355 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HC645_RS19360 ENOG4108NFA extracellular solute-binding protein HC645_RS19365 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HC645_RS19370 ENOG4108TGP Thioesterase superfamily protein HC645_RS19375 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HC645_RS19380 ENOG4105EIN peptidylprolyl cis-trans isomerase HC645_RS19385 ENOG4105K70 DNA-binding protein HC645_RS19390 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HC645_RS19395 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HC645_RS19405 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HC645_RS19415 ENOG4105M85 Bola protein HC645_RS19420 ENOG4105IEY (LipO)protein HC645_RS19425 ENOG4105EYM Major Facilitator superfamily HC645_RS19430 ENOG4105E2S oxidase) subunit II HC645_RS19435 ENOG4105BZ9 Cytochrome C oxidase, subunit I HC645_RS19440 ENOG4105CCU oxidase (Subunit III) HC645_RS19445 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HC645_RS19450 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HC645_RS19460 ENOG4107HP6 Transcriptional regulator HC645_RS19465 ENOG4105E2X shikimate dehydrogenase HC645_RS19470 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HC645_RS19480 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HC645_RS19490 ENOG4105D2S major facilitator superfamily HC645_RS19495 ENOG4105CIB oxidoreductase Domain protein HC645_RS19500 ENOG4107RDB Major Facilitator HC645_RS19510 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HC645_RS19515 ENOG4107S0N DJ-1 family HC645_RS19525 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HC645_RS19530 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HC645_RS19535 ENOG4105CTB Polyprenyl synthetase HC645_RS19540 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HC645_RS19545 ENOG4105CPC Aldo Keto reductase HC645_RS19550 ENOG4108ZAI phosphatidylglycerophosphatase a HC645_RS19555 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HC645_RS19560 ENOG4107YIM Involved in the transcription termination process (By similarity) HC645_RS19565 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HC645_RS19570 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HC645_RS19575 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HC645_RS19580 ENOG4108KIC (LipO)protein HC645_RS19585 ENOG4105DRB nucleoside-specific channel-forming protein HC645_RS19600 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HC645_RS19605 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HC645_RS19610 ENOG4105VIE preprotein translocase, subunit YajC HC645_RS19615 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HC645_RS19620 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HC645_RS19630 ENOG4108ZYK Acyl carrier protein phosphodiesterase HC645_RS19635 ENOG4105D3R alkyl hydroperoxide reductase HC645_RS19645 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HC645_RS19660 ENOG4108MGF sugar kinase HC645_RS19670 ENOG4105CI2 imidazolone-5-propionate hydrolase HC645_RS19680 ENOG4105CHJ isochorismatase hydrolase HC645_RS19685 ENOG4105EQ1 Transcriptional regulator HC645_RS19690 ENOG4107R28 alpha amylase, catalytic region HC645_RS19695 ENOG4105C85 amino acid HC645_RS19700 ENOG4105CWM branched-chain amino acid transport system II carrier protein HC645_RS19705 ENOG4105BZU Histidine kinase HC645_RS19710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC645_RS19715 ENOG4107RH8 nuclease SbcCD subunit D HC645_RS19720 ENOG4105EYH Exonuclease HC645_RS19725 ENOG4105DKQ ROK family HC645_RS19730 ENOG4105DH7 May be involved in recombination (By similarity) HC645_RS19735 ENOG4105NBK UPF0345 protein HC645_RS19740 ENOG4105HBA AroM protein HC645_RS19745 ENOG4105SS3 HC645_RS19750 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HC645_RS19755 ENOG4105G4C Periplasmic ligand-binding sensor protein HC645_RS19760 ENOG4108UPT UPF0178 protein HC645_RS19765 ENOG4105II7 pyrroline-5-carboxylate reductase HC645_RS19770 ENOG4105VIF phosphate starvation-inducible protein HC645_RS19775 ENOG4105G6Z alkaline phosphatase HC645_RS19795 ENOG4105CPF Cell wall formation (By similarity) HC645_RS19800 ENOG4105UNH Membrane HC645_RS19805 ENOG4105FR5 inner membrane protein YaiY HC645_RS19810 ENOG4107QS8 (LipO)protein HC645_RS19815 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HC645_RS19820 ENOG4108RWI nicotinamidase HC645_RS19825 ENOG4107R6D beta-lactam binding protein AmpH HC645_RS19830 ENOG4105D52 delta-aminolevulinic acid dehydratase HC645_RS19835 ENOG4108UK5 Transposase HC645_RS19845 ENOG4105E2B Taurine dioxygenase HC645_RS19850 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HC645_RS19855 ENOG4108ETV ABC transporter HC645_RS19860 ENOG4106FTQ Taurine ABC transporter, periplasmic HC645_RS19865 ENOG4107QK5 Homocysteine s-methyltransferase HC645_RS19870 ENOG4108IQI permease HC645_RS19880 ENOG4105C85 amino acid HC645_RS19885 ENOG4105CPD ethanolamine ammonia-lyase HC645_RS19890 ENOG4107FQ9 ethanolamine ammonia-lyase HC645_RS19905 ENOG4105C32 Amino acid ABC transporter (Permease) HC645_RS19910 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HC645_RS19915 ENOG4105C0Z ABC transporter HC645_RS19920 ENOG4108IV0 ABC, transporter HC645_RS19930 ENOG4105CT1 (ABC) transporter HC645_RS19935 ENOG4105CDA abc transporter atp-binding protein HC645_RS19940 ENOG4105EZ7 amino acid ABC transporter HC645_RS19945 ENOG4105DRP amino acid AbC transporter HC645_RS19955 ENOG4106PYX Receptor HC645_RS19960 ENOG4108N3D putative enzyme HC645_RS19965 ENOG4108NN8 Fimbrial protein HC645_RS19970 ENOG4108GWT fimbrillin MatB HC645_RS19975 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HC645_RS19985 ENOG4105EHI Phosphonate ABC transporter, periplasmic HC645_RS19995 ENOG4105S7S phosphonate abc transporter HC645_RS20015 ENOG4108QBX (LipO)protein HC645_RS20020 ENOG4105FCK Membrane HC645_RS20055 ENOG4105CVR type I restriction-modification system HC645_RS20065 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HC645_RS20120 ENOG4105TS0 gtp-binding protein HC645_RS20125 ENOG4106H6R UPF0380 protein HC645_RS20130 ENOG4108KZE transcriptional regulator HC645_RS20150 ENOG4106ZN7 UPF0401 protein YkfF HC645_RS20155 ENOG4105MFG Antirestriction protein HC645_RS20160 ENOG4108XS9 dna repair protein HC645_RS20165 ENOG4105ZS6 Protein of unknown function (DUF987) HC645_RS20190 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HC645_RS20200 ENOG41061ZR Transcriptional regulator HC645_RS20205 ENOG4107R0V Pyruvate dehydrogenase HC645_RS20210 ENOG4105CPP Dehydrogenase, E1 component HC645_RS20220 ENOG4107QN2 dihydrolipoyl dehydrogenase HC645_RS20230 ENOG41061GT Aldolase HC645_RS20240 ENOG4105CMG Carbohydrate kinase HC645_RS20245 ENOG4105CHR reductase HC645_RS20250 ENOG4108JQ1 Dehydrogenase HC645_RS20255 ENOG4105DT3 PTS system, galactitol-specific IIc component HC645_RS20260 ENOG4108TGY Glutathione S-transferase HC645_RS20265 ENOG4105DTA methyltransferase HC645_RS20270 ENOG4105YCT UPF0386 protein HC645_RS20280 ENOG4105D5U fad dependent oxidoreductase HC645_RS20285 ENOG4105C26 Dehydrogenase HC645_RS20290 ENOG4108JPW Aminotransferase HC645_RS20295 ENOG4105C85 amino acid HC645_RS20300 ENOG4108PVQ transcriptional regulator HC645_RS20305 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HC645_RS20310 ENOG4105V1F Fermentation respiration switch protein HC645_RS20315 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HC645_RS20320 ENOG4105CIN aminoacyl-histidine dipeptidase HC645_RS20325 ENOG4108HYG acetyltransferase HC645_RS20330 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC645_RS20345 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HC645_RS20350 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HC645_RS20355 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HC645_RS20360 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HC645_RS20365 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HC645_RS20370 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HC645_RS20375 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HC645_RS20380 ENOG4105E7A Glutamine amidotransferase HC645_RS20385 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HC645_RS20390 ENOG4107QPN acyl-Coa dehydrogenase HC645_RS20395 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HC645_RS20400 ENOG4108VP3 Lysine exporter protein (LysE YggA) HC645_RS20405 ENOG41090KR LysR family transcriptional Regulator HC645_RS20415 ENOG4107RZZ dna polymerase iii epsilon subunit HC645_RS20420 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HC645_RS20425 ENOG4105D1A Methyltransferase HC645_RS20430 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HC645_RS20435 ENOG4105E9H Lytic Murein transglycosylase HC645_RS20440 ENOG4105F2W methyltransferase HC645_RS20450 ENOG4105F27 Major Facilitator HC645_RS20455 ENOG4105HEI LysR family (Transcriptional regulator HC645_RS20460 ENOG4105CV8 reductase HC645_RS20495 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HC645_RS20500 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HC645_RS20505 ENOG4108UMI ABC transporter, permease HC645_RS20510 ENOG4105D01 (LipO)protein HC645_RS20515 ENOG4108R8X outer membrane lipoprotein HC645_RS20520 ENOG4108R96 Methyltransferase, YaeB family HC645_RS20525 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HC645_RS20530 ENOG4108UY0 (LipO)protein HC645_RS20535 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HC645_RS20540 ENOG4108YZN class I peptide chain release factor HC645_RS20545 ENOG4108VWS Yaeq family HC645_RS20550 ENOG4105W1I UPF0253 protein HC645_RS20555 ENOG4105M1T rho-binding antiterminator HC645_RS20560 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HC645_RS20565 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HC645_RS20570 ENOG4105CXN decarboxylase HC645_RS20575 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HC645_RS20580 ENOG4105C0B DNA polymerase III (alpha subunit) HC645_RS20585 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HC645_RS20590 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HC645_RS20595 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HC645_RS20600 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HC645_RS20605 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HC645_RS20610 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HC645_RS20620 ENOG4105DZP Membrane-associated zinc metalloprotease HC645_RS20625 ENOG4105KNE Phosphatidate cytidylyltransferase HC645_RS20635 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HC645_RS20645 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HC645_RS20650 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HC645_RS20655 ENOG4105CE9 30S ribosomal protein S2 HC645_RS20660 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HC645_RS20665 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HC645_RS20670 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HC645_RS20675 ENOG4108T8E UPF0325 protein HC645_RS20680 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HC645_RS20685 ENOG4105C0H protease HC645_RS20690 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HC645_RS20695 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HC645_RS20700 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HC645_RS20705 ENOG4105EN6 Membrane HC645_RS20710 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HC645_RS20715 ENOG4105CMQ Chloride channel HC645_RS20720 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HC645_RS20725 ENOG4105S6R Iron-hydroxamate transporter permease subunit HC645_RS20730 ENOG4105J76 Periplasmic binding protein HC645_RS20735 ENOG4105E0A ABC, transporter HC645_RS20740 ENOG4105E0K tonB-dependent siderophore receptor HC645_RS20745 ENOG4105BZ4 penicillin-binding protein HC645_RS20840 ENOG4105CQ7 ATP-dependent helicase HC645_RS20845 ENOG4107XID 2'-5' rna ligase HC645_RS20850 ENOG4105PW4 Sugar fermentation stimulation protein homolog HC645_RS20855 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HC645_RS20860 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HC645_RS20865 ENOG4105DJ0 Poly(A) Polymerase HC645_RS20870 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HC645_RS20875 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HC645_RS20880 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HC645_RS20885 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HC645_RS20890 ENOG4107BJW polysaccharide deacetylase HC645_RS20895 ENOG4108YTN IIa component HC645_RS20900 ENOG4105E3A (ABC) transporter HC645_RS20905 ENOG4105DA5 (ABC) transporter HC645_RS20910 ENOG41077A9 carbonic anhydrase HC645_RS20915 ENOG4108UGV hypoxanthine phosphoribosyltransferase HC645_RS20925 ENOG4105DZG Dehydrogenase HC645_RS20930 ENOG4105E3B Multicopper oxidase HC645_RS20935 ENOG4108ZRK uncharacterized protein yacC HC645_RS20955 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HC645_RS20960 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HC645_RS20965 ENOG4108ZIG UPF0231 protein HC645_RS20970 ENOG4107QIJ Aconitate hydratase 2 HC645_RS20980 ENOG4108NST exported protein HC645_RS20995 ENOG4107QN2 dihydrolipoyl dehydrogenase HC645_RS21000 ENOG4107QSN dihydrolipoamide acetyltransferase HC645_RS21005 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HC645_RS21010 ENOG41073TP transcriptional regulator HC645_RS21015 ENOG4105C85 amino acid HC645_RS21020 ENOG4105CT4 transporter HC645_RS21025 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HC645_RS21030 ENOG4106A72 regulatory protein AmpE HC645_RS21035 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HC645_RS21040 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HC645_RS21045 ENOG4108ZUW Major pilin subunit HC645_RS21050 ENOG4107QHF type ii secretion system protein e HC645_RS21055 ENOG4105D7Q type ii secretion system HC645_RS21060 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HC645_RS21065 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HC645_RS21070 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HC645_RS21075 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HC645_RS21080 ENOG4105M6F mutator MutT protein HC645_RS21085 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HC645_RS21090 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HC645_RS21095 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HC645_RS21100 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HC645_RS21105 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HC645_RS21110 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HC645_RS21120 ENOG4105DFU Cell wall formation (By similarity) HC645_RS21125 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HC645_RS21130 ENOG4105CNI cell division protein FtsW HC645_RS21140 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HC645_RS21145 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HC645_RS21150 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HC645_RS21155 ENOG4105CJN penicillin-binding protein HC645_RS21160 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HC645_RS21165 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HC645_RS21175 ENOG4107B7Y DNA-binding transcriptional regulator FruR HC645_RS21180 ENOG4108ZP8 Acetolactate synthase small subunit HC645_RS21185 ENOG4105C7K acetolactate synthase HC645_RS21190 ENOG41064T2 transcriptional regulator, lysR family HC645_RS21205 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HC645_RS21215 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HC645_RS21220 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HC645_RS21235 ENOG4105EMV Major Facilitator HC645_RS21240 ENOG4105FF2 Type I DHQase HC645_RS21245 ENOG4105C5Q Transcriptional regulator HC645_RS21250 ENOG4105DJB Major Facilitator Superfamily HC645_RS21255 ENOG4105S8Q sugar efflux transporter HC645_RS21280 ENOG4106SMU thiamine transporter membrane protein HC645_RS21290 ENOG4108KF1 Membrane HC645_RS21295 ENOG41063TF transcriptional regulator (AraC HC645_RS21305 ENOG4105EF1 ribulokinase HC645_RS21310 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HC645_RS21315 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HC645_RS21320 ENOG4105CQ2 DNA polymerase HC645_RS21325 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HC645_RS21330 ENOG4105D3G Pseudouridine synthase HC645_RS21345 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HC645_RS21350 ENOG4106YYS transcriptional regulatory protein HC645_RS21355 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HC645_RS21360 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HC645_RS21370 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HC645_RS21375 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HC645_RS21385 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HC645_RS21390 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HC645_RS21395 ENOG4105CKD glutathione-regulated potassium-efflux system protein HC645_RS21405 ENOG4105M5B (LipO)protein HC645_RS21410 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HC645_RS21415 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HC645_RS21425 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HC645_RS21430 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HC645_RS21435 ENOG4105CHY citrate lyase, alpha HC645_RS21440 ENOG4105CI0 Citrate lyase HC645_RS21445 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HC645_RS21450 ENOG4105DUA (citrate (pro-3S)-lyase ligase HC645_RS21455 ENOG4105D2K citrate carrier protein HC645_RS21465 ENOG4107QSA Oxaloacetate decarboxylase HC645_RS21470 ENOG4105D9Q decarboxylase (Beta subunit) HC645_RS21475 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HC645_RS21480 ENOG4106YYS transcriptional regulatory protein HC645_RS21485 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HC645_RS21490 ENOG4105EXG Transcriptional regulator HC645_RS21500 ENOG4105DU0 nucleoside hydrolase HC645_RS21505 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HC645_RS21510 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HC645_RS21515 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HC645_RS21525 ENOG4105DTN riboflavin biosynthesis protein ribF HC645_RS21545 ENOG41063Z6 transcriptional regulator, lysR family HC645_RS21550 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HC645_RS21555 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HC645_RS21560 ENOG4105CFG Acts as a chaperone (By similarity) HC645_RS21565 ENOG4108WTA UPF0412 protein YaaI HC645_RS21570 ENOG4108QUJ UPF0174 protein YaaW HC645_RS21575 ENOG4106HK8 GPR1 FUN34 yaaH family protein HC645_RS21580 ENOG4105CSH Transporter HC645_RS21585 ENOG4108RIR Molybdenum cofactor biosynthesis protein HC645_RS21590 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HC645_RS21600 ENOG4105D1Q UPF0246 protein HC645_RS21610 ENOG4105D98 threonine synthase HC645_RS21615 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HC645_RS21620 ENOG4105CFH Aspartokinase HC645_RS21635 ENOG4106FVC RNA methyltransferase HC645_RS21640 ENOG410759A HC645_RS21645 ENOG41065U4 response regulator HC645_RS21650 ENOG4105CT7 inner membrane cred family protein HC645_RS21655 ENOG4105EB3 Histidine kinase HC645_RS21660 ENOG4105E3W Two component transcriptional regulator (Winged helix family HC645_RS21665 ENOG4108RH0 Crea protein HC645_RS21670 ENOG4105UEI Transcriptional Regulator AraC Family HC645_RS21675 ENOG4105CVJ phosphoglycerate mutase HC645_RS21680 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HC645_RS21685 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HC645_RS21690 ENOG4107SC1 transglycosylase HC645_RS21695 ENOG4105C5H ABC transporter HC645_RS21700 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HC645_RS21705 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HC645_RS21710 ENOG4105EAC phosphoserine phosphatase HC645_RS21715 ENOG41062Z9 Membrane HC645_RS21720 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HC645_RS21735 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HC645_RS21745 ENOG4105D9N nucleoside HC645_RS21750 ENOG4105EYA deoxyribonuclease HC645_RS21755 ENOG4108NRW Phospholipase, patatin family HC645_RS21760 ENOG41075IC Protein of unknown function (DUF1328) HC645_RS21765 ENOG4105K3G Periplasmic Protein HC645_RS21770 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HC645_RS21775 ENOG4105PAD Hydrolase HC645_RS21780 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HC645_RS21785 ENOG4108WPU DNA polymerase III subunit psi HC645_RS21790 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HC645_RS21810 ENOG4105YBH Protein of unknown function (DUF1435) HC645_RS21820 ENOG4106TD9 Diguanylate cyclase HC645_RS21825 ENOG4108819 ferric iron reductase HC645_RS21830 ENOG4105CK1 PTS System HC645_RS21835 ENOG4108UIN ybak prolyl-trna synthetase associated region HC645_RS21840 ENOG4108T94 DNA-binding transcriptional activator BglJ HC645_RS21845 ENOG4108N8T regulatoR HC645_RS21855 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HC645_RS21860 ENOG4105DWK Membrane HC645_RS21865 ENOG4107XM3 UPF0442 protein HC645_RS21870 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HC645_RS21875 ENOG4106CVF DNA replication protein HC645_RS21880 ENOG4105RI1 glycoprotein receptor HC645_RS21890 ENOG4105DNE Transposase HC645_RS21905 ENOG4105F3R pts system mannose fructose sorbose family iid HC645_RS21910 ENOG4105ETZ PTS System HC645_RS21915 ENOG4105KPI PTS system sorbose subfamily IIB component HC645_RS21925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HC645_RS21935 ENOG4105XYF acetyltransferase HC645_RS21940 ENOG4106KNT transcriptional regulator HC645_RS21945 ENOG4108RTU Aldolase HC645_RS21950 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HC645_RS21980 ENOG4105DG4 malate L-lactate dehydrogenase HC645_RS21995 ENOG4108V8F Transcriptional regulator, MarR family HC645_RS22005 ENOG4105ERH Fumarylacetoacetate hydrolase HC645_RS22015 ENOG4105C26 Dehydrogenase HC645_RS22020 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HC645_RS22035 ENOG4105CNV Aldolase HC645_RS22045 ENOG4108NKV transcriptional regulator HC645_RS22050 ENOG4105EFA 4-hydroxyphenylacetate HC645_RS22055 ENOG4107UWN reductase HC645_RS22070 ENOG4105D22 carbon starvation protein HC645_RS22075 ENOG4105VCD cytoplasmic protein HC645_RS22080 ENOG4105CKI cobalamin synthesis protein HC645_RS22095 ENOG4105C26 Dehydrogenase HC645_RS22100 ENOG4105DNE Transposase HC645_RS22105 ENOG4106AXJ AraC family transcriptional regulator HC645_RS22115 ENOG4106BRA Membrane HC645_RS22120 ENOG41083G8 Multidrug resistance protein MdtM HC645_RS22130 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HC645_RS22135 ENOG4105CIZ coA-substrate-specific enzyme activase HC645_RS22150 ENOG4105EFX secretion protein, HlyD family HC645_RS22160 ENOG4106DIZ Domain of unknown function (DUF1127) HC645_RS22165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC645_RS22170 ENOG4106H3A restriction HC645_RS22175 ENOG4105CVR type I restriction-modification system HC645_RS22180 ENOG4105EKX Restriction modification system DNA (Specificity HC645_RS22185 ENOG4105DZR Type I site-specific deoxyribonuclease HC645_RS22200 ENOG41064T2 transcriptional regulator, lysR family HC645_RS22205 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HC645_RS22210 ENOG4105CNN ABC, transporter HC645_RS22215 ENOG4105CNN ABC, transporter HC645_RS22220 ENOG4105C2J ABC transporter HC645_RS22225 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HC645_RS22235 ENOG4105D0S secretion protein (HlyD HC645_RS22240 ENOG4105CJ1 ABC, transporter HC645_RS22245 ENOG4105CMI transporter HC645_RS22275 ENOG4105EZE Cupin 4 family protein HC645_RS22290 ENOG4105GR3 Histidine kinase HC645_RS22295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC645_RS22300 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HC645_RS22305 ENOG410624V efflux system protein HC645_RS22310 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HC645_RS22315 ENOG4108IJF Heavy metal efflux pump, CzcA HC645_RS22325 ENOG4105QNF Outer membrane lipoprotein HC645_RS22330 ENOG4108XDN Transcriptional regulator HC645_RS22340 ENOG4107FW0 short-chain dehydrogenase reductase HC645_RS22355 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HC645_RS22375 ENOG4107SEY Conserved Protein HC645_RS22380 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HC645_RS22385 ENOG4105C93 Xylose Isomerase HC645_RS22390 ENOG4105CT4 transporter HC645_RS22395 ENOG4105DSG hydrolase family 43 HC645_RS22415 ENOG4107S6X Glycosyl transferase, family 2 HC645_RS22460 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HC645_RS22465 ENOG4108XS9 dna repair protein HC645_RS22470 ENOG4105MFG Antirestriction protein HC645_RS22475 ENOG4106H6R UPF0380 protein HC645_RS22480 ENOG4106J9S Prophage HC645_RS22490 ENOG4108KZE transcriptional regulator HC645_RS22495 ENOG4108MXD gtp-binding protein HC645_RS22540 ENOG4105DZR Type I site-specific deoxyribonuclease HC645_RS22575 ENOG41077A9 carbonic anhydrase HC645_RS22580 ENOG4105CHH sulfate transporter HC645_RS22585 ENOG4105DQ4 alcohol dehydrogenase HC645_RS22595 ENOG4105DRS transport system, permease HC645_RS22600 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HC645_RS22605 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HC645_RS22615 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HC645_RS22620 ENOG4105F0H myo-inositol catabolism protein HC645_RS22625 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HC645_RS22630 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HC645_RS22640 ENOG4105D7K pfkb domain protein HC645_RS22645 ENOG4105CHC glucokinase (EC 2.7.1.2) HC645_RS22650 ENOG4105DH8 myo-inositol catabolism HC645_RS22655 ENOG4105C26 Dehydrogenase HC645_RS22665 ENOG4105D7A ATP-binding protein HC645_RS22670 ENOG4108K5H permease YjgP YjgQ family protein HC645_RS22675 ENOG4108M8S permease YjgP YjgQ family protein HC645_RS22680 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HC645_RS22685 ENOG4105MYG DNA polymerase iii, chi subunit HC645_RS22690 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HC645_RS22695 ENOG4108MJ3 acetyltransferase HC645_RS22700 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HC645_RS22705 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HC645_RS22715 ENOG4105XEP YhcH YjgK YiaL family protein HC645_RS22725 ENOG4105CXT aspartate transcarbamylase HC645_RS22730 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HC645_RS22735 ENOG4105KME endoribonuclease L-psp HC645_RS22745 ENOG4105D4X repressor HC645_RS22750 ENOG4105C5Y PTS System HC645_RS22755 ENOG4105CG3 alpha amylase, catalytic region HC645_RS22760 ENOG4105CK1 PTS System HC645_RS22765 ENOG4105F8D glycoside hydrolase family 4 HC645_RS22785 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HC645_RS22790 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HC645_RS22795 ENOG4105K4U addiction module toxin, RelE StbE family HC645_RS22805 ENOG4105EMD TRANSCRIPTIONal HC645_RS22810 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HC645_RS22825 ENOG41069H0 dihydroorotase EC 3.5.2.3 HC645_RS22860 ENOG4108XVM Cytochrome b(562) HC645_RS22865 ENOG4105CMS peptidase U62, modulator of DNA gyrase HC645_RS22870 ENOG4105N42 UPF0307 protein HC645_RS22890 ENOG4105DFU Cell wall formation (By similarity) HC645_RS22895 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HC645_RS22900 ENOG41062B0 ABC transporter, permease HC645_RS22905 ENOG4107R9N ABC transporter HC645_RS22910 ENOG4105C2J ABC transporter HC645_RS22915 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HC645_RS22920 ENOG4105F0N pyrophosphate phospho-hydrolase HC645_RS22935 ENOG4108ZHD aig2 family HC645_RS22940 ENOG4105MA0 exported protein HC645_RS22945 ENOG4105CFU surface antigen HC645_RS22955 ENOG4105C37 (CBS) domain HC645_RS22965 ENOG4105C4C beta-galactosidase HC645_RS22975 ENOG41061GZ Protein of unknown function (DUF1107) HC645_RS22980 ENOG4108UUE Transcriptional regulator HC645_RS22985 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HC645_RS22990 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HC645_RS22995 ENOG4105KVH Transcriptional regulator HC645_RS23000 ENOG4105ECR NmrA family HC645_RS23010 ENOG4105DXC membrane HC645_RS23015 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HC645_RS23025 ENOG4108V1T peptidylprolyl cis-trans isomerase HC645_RS23030 ENOG4105FHY Opacity-associated protein A HC645_RS23035 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HC645_RS23040 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HC645_RS23045 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HC645_RS23050 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HC645_RS23055 ENOG4105KIT UPF0379 protein yjfY HC645_RS23080 ENOG4106ETB IIa component HC645_RS23090 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HC645_RS23105 ENOG4108MXZ Esterase HC645_RS23110 ENOG4105WSB biofilm stress and motility protein A HC645_RS23115 ENOG4105S17 UPF0379 protein yjfN HC645_RS23120 ENOG4105CSU acyl-Coa dehydrogenase HC645_RS23125 ENOG4105C2N RNA methyltransferase TrmH family group 3 HC645_RS23130 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HC645_RS23135 ENOG4105KPV Transcriptional regulator HC645_RS23140 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HC645_RS23155 ENOG4105EPW hflc protein HC645_RS23160 ENOG4107QJR hflk protein HC645_RS23165 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HC645_RS23175 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HC645_RS23180 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HC645_RS23190 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC645_RS23195 ENOG4105K8N protein family UPF0079, ATPase HC645_RS23200 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HC645_RS23205 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HC645_RS23225 ENOG4106TNF Periplasmic binding protein HC645_RS23230 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HC645_RS23235 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HC645_RS23240 ENOG4105DJ4 phosphatidylserine decarboxylase HC645_RS23245 ENOG4105EGS Mechanosensitive ion channel HC645_RS23250 ENOG4107SC7 Inner membrane transporter yjeM HC645_RS23255 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HC645_RS23260 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HC645_RS23265 ENOG4105E33 succinate dehydrogenase HC645_RS23275 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HC645_RS23285 ENOG4105KPY Small multidrug resistance protein HC645_RS23290 ENOG4106BSU Entericidin B HC645_RS23300 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HC645_RS23305 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HC645_RS23310 ENOG4105CJZ response regulator HC645_RS23315 ENOG4108MBX Secretion Protein HC645_RS23320 ENOG4108JJA ABC, transporter HC645_RS23330 ENOG4108ZVF (LipO)protein HC645_RS23340 ENOG4108VCD Chaperone HC645_RS23345 ENOG4105CW0 outer membrane usher protein HC645_RS23350 ENOG4105MX3 Fimbrial HC645_RS23360 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HC645_RS23370 ENOG4105DVH amino acid HC645_RS23375 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HC645_RS23380 ENOG4108IJ0 Aspartate ammonia-lyase HC645_RS23385 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HC645_RS23395 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HC645_RS23400 ENOG4108SIC Transcriptional regulator HC645_RS23440 ENOG4108TUY outer membrane protein PgaA HC645_RS23445 ENOG4107BJW polysaccharide deacetylase HC645_RS23450 ENOG4105CND Glycosyl transferase, family 2 HC645_RS23470 ENOG4108ZCF integral membrane protein HC645_RS23480 ENOG4105DVC DnaJ domain protein HC645_RS23510 ENOG4105F8D glycoside hydrolase family 4 HC645_RS23515 ENOG4108K2B transcriptional regulator HC645_RS23520 ENOG4105CSH Transporter HC645_RS23525 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HC645_RS23530 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HC645_RS23535 ENOG4107RJJ Transcriptional regulator HC645_RS23540 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HC645_RS23545 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HC645_RS23550 ENOG4105EKV Phosphonate metabolism protein HC645_RS23555 ENOG4105FT8 Phosphonate metabolism HC645_RS23560 ENOG4105ENV phosphonate C-P lyase system protein PhnK HC645_RS23565 ENOG4105HRV phosphonate c-p lyase system protein phnl HC645_RS23570 ENOG4105FD8 phosphonate metabolism protein PhnM HC645_RS23575 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HC645_RS23580 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HC645_RS23590 ENOG4105BZU Histidine kinase HC645_RS23595 ENOG4105C2J ABC transporter HC645_RS23600 ENOG4105CNN ABC, transporter HC645_RS23605 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HC645_RS23635 ENOG41082ND Uncharacterized protein yjcO HC645_RS23640 ENOG4105CK2 sodium dicarboxylate symporter HC645_RS23650 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HC645_RS23655 ENOG41062QD Membrane HC645_RS23660 ENOG4107QN1 sodium solute HC645_RS23675 ENOG4105CW0 outer membrane usher protein HC645_RS23680 ENOG4108VCD Chaperone HC645_RS23685 ENOG4105MX3 Fimbrial HC645_RS23695 ENOG41067MG lrgb family HC645_RS23705 ENOG4105CMU LysR family (Transcriptional regulator HC645_RS23710 ENOG4105EEQ Na H antiporter HC645_RS23715 ENOG4105C7N Xanthine uracil vitamin C permease HC645_RS23720 ENOG4108K3A Glutathione S-transferase HC645_RS23725 ENOG4108Z4X TRANSCRIPTIONal HC645_RS23730 ENOG4108W3Q Transcriptional regulator HC645_RS23735 ENOG4108M8H domain protein HC645_RS23740 ENOG4105PMV Membrane HC645_RS23765 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HC645_RS23770 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS23775 ENOG4105ECY inositol monophosphatase HC645_RS23785 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HC645_RS23805 ENOG4108DMH HTH_ARAC HC645_RS23810 ENOG4107RNH Outer membrane receptor FepA HC645_RS23825 ENOG4105E4C Lytic transglycosylase catalytic HC645_RS23850 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HC645_RS23910 ENOG4108FPN Integrase HC645_RS23915 ENOG4108UUM single-stranded DNA-binding protein HC645_RS23920 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HC645_RS23925 ENOG4105MSB protein, conserved in bacteria HC645_RS23930 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HC645_RS23940 ENOG4105CGF Aromatic amino acid aminotransferase HC645_RS23945 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HC645_RS23950 ENOG4105CDU Replicative dna helicase HC645_RS23955 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HC645_RS23960 ENOG4105P4Z Phage shock protein G HC645_RS23965 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HC645_RS23975 ENOG4105MYN Zinc uptake regulation protein HC645_RS23980 ENOG4105VDW Csbd family HC645_RS23985 ENOG4107R73 Mate efflux family protein HC645_RS23995 ENOG41080IJ Diacylglycerol kinase HC645_RS24000 ENOG4105E55 glycerol-3-phosphate acyltransferase HC645_RS24005 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HC645_RS24010 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HC645_RS24015 ENOG4107W52 maltose operon periplasmic protein HC645_RS24020 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HC645_RS24025 ENOG4108IJ9 (ABC) transporter HC645_RS24030 ENOG4107FKK extracellular solute-binding protein family 1 HC645_RS24035 ENOG4105D56 permease protein HC645_RS24040 ENOG4105EG2 ABC transporter, permease HC645_RS24045 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HC645_RS24050 ENOG4105CEM UPF0597 protein HC645_RS24065 ENOG4105KME endoribonuclease L-psp HC645_RS24075 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HC645_RS24080 ENOG4107QP8 phosphohexose isomerase HC645_RS24085 ENOG4105CFH Aspartokinase HC645_RS24090 ENOG4105C09 Bile acid HC645_RS24095 ENOG4108ZR5 Conserved Protein HC645_RS24100 ENOG4105FE9 pseudouridine synthase HC645_RS24105 ENOG4105DKT Transcriptional regulator HC645_RS24110 ENOG4105CHR reductase HC645_RS24115 ENOG4108XCU pts system HC645_RS24120 ENOG4105KPI PTS system sorbose subfamily IIB component HC645_RS24125 ENOG4105ETZ PTS System HC645_RS24130 ENOG4105F3R pts system mannose fructose sorbose family iid HC645_RS24135 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HC645_RS24140 ENOG4105F9E Shikimate 5-dehydrogenase HC645_RS24145 ENOG4105EAM Na Pi-cotransporter HC645_RS24150 ENOG4105C3R Methionine synthase HC645_RS24155 ENOG41069M3 Transcriptional regulator HC645_RS24160 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HC645_RS24165 ENOG4108I9X Isocitrate lyase HC645_RS24170 ENOG4107QP3 malate synthase g HC645_RS24175 ENOG4105CVG Homoserine O-transsuccinylase HC645_RS24180 ENOG4105K5X acetyltransferase HC645_RS24205 ENOG4105DC1 bifunctional purine biosynthesis protein purh HC645_RS24210 ENOG4105C12 Phosphoribosylglycinamide synthetase HC645_RS24220 ENOG4105BZU Histidine kinase HC645_RS24225 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HC645_RS24230 ENOG4108T8B Protein of unknown function (DUF1481) HC645_RS24235 ENOG4105K70 DNA-binding protein HC645_RS24240 ENOG4105R2J Conserved Protein HC645_RS24245 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HC645_RS24250 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HC645_RS24255 ENOG4105E09 nadh pyrophosphatase HC645_RS24260 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HC645_RS24265 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HC645_RS24270 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HC645_RS24275 ENOG4105D06 uba thif-type nad fad binding protein HC645_RS24280 ENOG4105WHD thiamine biosynthesis protein ThiS HC645_RS24285 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HC645_RS24290 ENOG4105D41 biosynthesis protein thiH HC645_RS24295 ENOG4106TD9 Diguanylate cyclase HC645_RS24305 ENOG4105VCP PTS System HC645_RS24310 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HC645_RS24315 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC645_RS24320 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC645_RS24325 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HC645_RS24330 ENOG4108VZM 50s ribosomal protein L10 HC645_RS24335 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HC645_RS24340 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HC645_RS24345 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HC645_RS24350 ENOG4105PM1 preprotein translocase subunit SecE HC645_RS24355 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HC645_RS24380 ENOG4105CS9 pantothenic acid kinase HC645_RS24385 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HC645_RS24420 ENOG4108RR8 protoporphyrinogen oxidase HC645_RS24425 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HC645_RS24430 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HC645_RS24435 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HC645_RS24440 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) HC645_RS24445 ENOG4105CHU acetyl-coa acetyltransferase HC645_RS24450 ENOG4107QK7 reductase HC645_RS24455 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HC645_RS24465 ENOG4105MDZ Transcriptional activator rfaH HC645_RS24475 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HC645_RS24480 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HC645_RS24485 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HC645_RS24490 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HC645_RS24495 ENOG4105JC1 sterol-binding domain protein HC645_RS24500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HC645_RS24505 ENOG4105CGY Dna recombination protein HC645_RS24510 ENOG4107SXA Phosphorylase HC645_RS24515 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HC645_RS24520 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HC645_RS24525 ENOG4105DZ2 Transcriptional regulator HC645_RS24530 ENOG4105EMK carboxylate amino acid amine transporter HC645_RS24535 ENOG4105DQF Hydrolase HC645_RS24540 ENOG4108EUD Lysophospholipase HC645_RS24545 ENOG410829K Lysine exporter protein (Lyse ygga) HC645_RS24555 ENOG4105CCF Lysine exporter protein (Lyse ygga) HC645_RS24560 ENOG4105C9U ATP-dependent DNA helicase RecQ HC645_RS24565 ENOG4105HDD phospholipase HC645_RS24570 ENOG4108VUY thioesterase Superfamily protein HC645_RS24575 ENOG4105FR1 rard protein HC645_RS24580 ENOG4107QUT magnesium and cobalt transport protein CorA HC645_RS24585 ENOG4105C4R Atp-dependent dna helicase HC645_RS24590 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HC645_RS24595 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HC645_RS24600 ENOG4105CT0 Protein of unknown function, DUF484 HC645_RS24610 ENOG4105S7Z (LipO)protein HC645_RS24615 ENOG4105XQ6 frataxin-like protein HC645_RS24620 ENOG4107T0K Adenylate cyclase HC645_RS24625 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HC645_RS24630 ENOG41076E6 Uroporphyrinogen-III Synthase HC645_RS24635 ENOG4105ECF c-methyltransferase HC645_RS24640 ENOG410601J HemY protein HC645_RS24670 ENOG4105C85 amino acid HC645_RS24675 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HC645_RS24680 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HC645_RS24685 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HC645_RS24690 ENOG4105EGZ biosynthesis protein HC645_RS24695 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HC645_RS24700 ENOG4108WJ1 acetyltransferase HC645_RS24705 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HC645_RS24710 ENOG4105C1B dTDP-glucose 4-6-dehydratase HC645_RS24715 ENOG4107QQG Dehydrogenase HC645_RS24720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HC645_RS24725 ENOG4105SFE lipopolysaccharide biosynthesis protein HC645_RS24730 ENOG4105ESV Glycosyl transferase, family 4 HC645_RS24735 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HC645_RS24745 ENOG4105C1J atp-dependent rna helicase HC645_RS24750 ENOG4105C9X ppx gppa phosphatase HC645_RS24765 ENOG4108UQV Membrane HC645_RS24770 ENOG4105C4R Atp-dependent dna helicase HC645_RS24775 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HC645_RS24780 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HC645_RS24785 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HC645_RS24790 ENOG4105EMY transcriptional regulator HC645_RS24795 ENOG4105C7B Threonine dehydratase HC645_RS24800 ENOG4105C01 Dihydroxy-acid dehydratase HC645_RS24805 ENOG4105CM2 brancheD-chain amino acid aminotransferase HC645_RS24810 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HC645_RS24825 ENOG4105C0P Mg chelatase subunit ChlI HC645_RS24830 ENOG4108WFC UPF0438 protein yifE HC645_RS24885 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HC645_RS24890 ENOG4108Y73 Membrane HC645_RS24895 ENOG4105EJ2 Transcriptional regulator HC645_RS24900 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HC645_RS24905 ENOG4105C5Q Transcriptional regulator HC645_RS24910 ENOG4105CH7 arginosuccinase HC645_RS24915 ENOG4105CAS nag kinase HC645_RS24920 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HC645_RS24935 ENOG4108MEK Metal-binding protein YodA HC645_RS24940 ENOG4106R3P AraC family transcriptional regulator HC645_RS24945 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HC645_RS24950 ENOG4105DCT glycerol dehydrogenase HC645_RS24955 ENOG4108Q5Y Membrane HC645_RS24960 ENOG4105SYT Methylenetetrahydrofolate reductase HC645_RS24965 ENOG4105CN8 Transcriptional regulator HC645_RS24970 ENOG4108Z8I decarboxylase HC645_RS24975 ENOG4105CGH 5'-nucleotidase HC645_RS24985 ENOG4105CFH Aspartokinase HC645_RS24990 ENOG4105C28 cystathionine HC645_RS24995 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HC645_RS25000 ENOG4105VFB Binds the 23S rRNA (By similarity) HC645_RS25005 ENOG4105C25 Primosomal protein n' HC645_RS25010 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS25015 ENOG41063M6 Cell Division Protein HC645_RS25020 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HC645_RS25030 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HC645_RS25035 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HC645_RS25040 ENOG4105CTQ phosphohexokinase HC645_RS25045 ENOG41076HS cation diffusion facilitator family transporter HC645_RS25050 ENOG4105FMW periplasmic HC645_RS25055 ENOG4105E3W Two component transcriptional regulator (Winged helix family HC645_RS25060 ENOG4105E0F Histidine kinase HC645_RS25065 ENOG4108RPX mosc domain containing protein HC645_RS25070 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HC645_RS25075 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HC645_RS25080 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HC645_RS25085 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HC645_RS25090 ENOG4105DET Rhamnulokinase HC645_RS25095 ENOG4105DKG l-rhamnose isomerase HC645_RS25100 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HC645_RS25105 ENOG4105D4B ABC, transporter HC645_RS25110 ENOG4105C2J ABC transporter HC645_RS25115 ENOG4105CNN ABC, transporter HC645_RS25120 ENOG4105CNN ABC, transporter HC645_RS25135 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HC645_RS25170 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HC645_RS25180 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HC645_RS25185 ENOG4108MG3 formate dehydrogenase HC645_RS25190 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HC645_RS25200 ENOG41068KX affects formate dehydrogenase-N HC645_RS25210 ENOG4105SUU thioesterase domain HC645_RS25215 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HC645_RS25220 ENOG4107S2Z UPF0761 membrane protein HC645_RS25225 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HC645_RS25230 ENOG4105CI3 gtp-binding protein typa HC645_RS25235 ENOG4105C5F glutamine synthetase HC645_RS25240 ENOG4105CUX Signal transduction histidine kinase HC645_RS25245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HC645_RS25250 ENOG4106FIY HC645_RS25255 ENOG4105D4P Coproporphyrinogen iii oxidase HC645_RS25260 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HC645_RS25265 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HC645_RS25270 ENOG4105C2M dna polymerase I HC645_RS25275 ENOG4106HNH Acyl-transferase HC645_RS25280 ENOG4108Z33 Thiol disulfide Interchange Protein HC645_RS25285 ENOG4105E27 serine threonine protein kinase HC645_RS25290 ENOG4105PC1 Conserved Protein HC645_RS25295 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HC645_RS25300 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HC645_RS25325 ENOG4107EJG GntR family transcriptional regulator HC645_RS25330 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC645_RS25335 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS25340 ENOG4108RVA ribokinase HC645_RS25345 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HC645_RS25350 ENOG4105CNN ABC, transporter HC645_RS25355 ENOG4105C2J ABC transporter HC645_RS25365 ENOG4105DFH Transport of potassium into the cell (By similarity) HC645_RS25380 ENOG4105CU9 asparagine synthetase A HC645_RS25385 ENOG4108VVK transcriptional Regulator, AsnC HC645_RS25390 ENOG4105QTB Flavodoxin HC645_RS25395 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HC645_RS25400 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HC645_RS25405 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HC645_RS25425 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HC645_RS25430 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HC645_RS25435 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HC645_RS25440 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HC645_RS25445 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HC645_RS25465 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HC645_RS25470 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HC645_RS25475 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HC645_RS25480 ENOG4105C8U phosphate abc transporter HC645_RS25485 ENOG4105E2Z phosphate ABC transporter (Permease HC645_RS25490 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HC645_RS25510 ENOG4105DYC esterase HC645_RS25515 ENOG4107VKM 6-phosphogluconolactonase HC645_RS25520 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HC645_RS25530 ENOG4105C7N Xanthine uracil vitamin C permease HC645_RS25535 ENOG4108YYH Nadph-dependent fmn reductase HC645_RS25540 ENOG4105E8Q phosphopantetheinyl transferase HC645_RS25550 ENOG4105C2C drug resistance transporter, Bcr CflA HC645_RS25560 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HC645_RS25565 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HC645_RS25570 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HC645_RS25580 ENOG4105VG0 50S ribosomal protein l34 HC645_RS25585 ENOG4108PG2 copper resistance HC645_RS25590 ENOG4105JDN Copper resistance protein HC645_RS25595 ENOG4105VR0 copper resistance HC645_RS25600 ENOG4105E3B Multicopper oxidase HC645_RS25610 ENOG4105DR5 peptidase HC645_RS25640 ENOG410624V efflux system protein HC645_RS25680 ENOG4105BZU Histidine kinase HC645_RS25730 ENOG4105CAU Arsenical resistance protein, ArsH HC645_RS25755 ENOG4107QN2 dihydrolipoyl dehydrogenase HC645_RS25765 ENOG4108SF5 RNA Polymerase HC645_RS25770 ENOG4108S3W Anti-feci sigma factor, fecr HC645_RS25775 ENOG4105GAV receptor HC645_RS25780 ENOG4108HUF Transporter HC645_RS25785 ENOG4105DQ5 transport system permease protein HC645_RS25790 ENOG4108IHU transport system permease protein HC645_RS25795 ENOG4105E0A ABC, transporter HC645_RS25800 ENOG4108YXQ IS66 Orf2 family protein HC645_RS25825 ENOG4105KBH arsR family transcriptional regulator HC645_RS25830 ENOG4105CAU Arsenical resistance protein, ArsH HC645_RS25870 ENOG4105CIS alcohol dehydrogenase HC645_RS25885 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HC645_RS25915 ENOG4105EKE dihydroorotase HC645_RS25925 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HC645_RS25930 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HC645_RS25935 ENOG4107RGD Major Facilitator superfamily HC645_RS25945 ENOG4105F2I Transposase HC645_RS25950 ENOG4105FXM Copper resistance protein HC645_RS26040 ENOG4105ETE Transcriptional regulator (LacI family HC645_RS26050 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HC645_RS26125 ENOG4108YXQ IS66 Orf2 family protein HC645_RS26130 ENOG4105E5H Transposase HC645_RS26200 ENOG4105KF5 hemolysin expression-modulating protein HC645_RS26210 ENOG4106JVB Replication Protein HC645_RS26240 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HC645_RS26245 ENOG4108Z3N Transcriptional regulator HC645_RS26340 ENOG4108JEH abc transporter atp-binding protein HC645_RS26345 ENOG4105E5Q amino acid AbC transporter HC645_RS26350 ENOG4105E5Q amino acid AbC transporter HC645_RS26360 ENOG4105ETT transcriptional Regulator, LysR family HC645_RS26380 ENOG4108YXQ IS66 Orf2 family protein HC645_RS26395 ENOG4105GR3 Histidine kinase HC645_RS26400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family