locus-tag	class	description
HC645_RS00020	COG0187	DNA topoisomerase II activity
HC645_RS00025	COG0561	phosphatase activity
HC645_RS00040	COG2186	Transcriptional regulator
HC645_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HC645_RS00050	COG0800	Aldolase
HC645_RS00060	COG2271	Major facilitator Superfamily
HC645_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HC645_RS00070	COG5645	(Lipo)protein
HC645_RS00095	COG2188	Transcriptional regulator
HC645_RS00110	COG2149	membrane
HC645_RS00130	COG2610	gluconate transmembrane transporter activity
HC645_RS00140	COG0583	DNA-binding transcription factor activity
HC645_RS00145	COG2814	Major facilitator Superfamily
HC645_RS00175	COG0028	Belongs to the TPP enzyme family
HC645_RS00180	COG0440	acetolactate synthase activity
HC645_RS00185	COG2197	response regulator
HC645_RS00195	COG2271	Major facilitator Superfamily
HC645_RS00245	COG2188	Transcriptional regulator
HC645_RS00270	COG4580	involved in the transport of maltose and maltodextrins
HC645_RS00275	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC645_RS00280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS00280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS00285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS00290	COG1609	Transcriptional regulator
HC645_RS00300	COG3384	dioxygenase
HC645_RS00305	COG0583	DNA-binding transcription factor activity
HC645_RS00310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC645_RS00315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HC645_RS00320	COG2828	Protein conserved in bacteria
HC645_RS00335	COG0697	spore germination
HC645_RS00340	COG1263	PTS System
HC645_RS00340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS00350	COG2814	Major facilitator Superfamily
HC645_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC645_RS00395	COG0583	DNA-binding transcription factor activity
HC645_RS00420	COG1464	Belongs to the NlpA lipoprotein family
HC645_RS00435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC645_RS00445	COG1064	alcohol dehydrogenase
HC645_RS00475	COG2211	Major facilitator Superfamily
HC645_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
HC645_RS00490	COG1486	melibiose metabolic process
HC645_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS00495	COG1263	PTS System
HC645_RS00500	COG2982	Protein involved in outer membrane biogenesis
HC645_RS00505	COG2233	PERMEase
HC645_RS00510	COG0786	glutamate:sodium symporter activity
HC645_RS00530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HC645_RS00555	COG3152	Membrane
HC645_RS00565	COG1494	fructose-1,6-bisphosphatase
HC645_RS00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC645_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC645_RS00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC645_RS00600	COG2860	membrane
HC645_RS00610	COG2169	Transcriptional regulator
HC645_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC645_RS00615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC645_RS00655	COG1484	DNA-dependent DNA replication
HC645_RS00660	COG4584	PFAM Integrase catalytic
HC645_RS00695	COG3561	AntA/AntB antirepressor
HC645_RS00720	COG1561	YicC-like family, N-terminal region
HC645_RS00745	COG1131	(ABC) transporter
HC645_RS00750	COG0842	Transport permease protein
HC645_RS00775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC645_RS00795	COG4245	von Willebrand factor, type A
HC645_RS00830	COG1519	Transferase
HC645_RS00835	COG1216	Glycosyl transferase, family 2
HC645_RS00840	COG0438	transferase activity, transferring glycosyl groups
HC645_RS00850	COG0859	PFAM glycosyl transferase family 9
HC645_RS00860	COG1216	Glycosyl transferase, family 2
HC645_RS00860	COG1442	glycosyl transferase family 8
HC645_RS00865	COG3307	-O-antigen
HC645_RS00870	COG0438	transferase activity, transferring glycosyl groups
HC645_RS00875	COG0859	PFAM glycosyl transferase family 9
HC645_RS00890	COG0156	8-amino-7-oxononanoate synthase activity
HC645_RS00900	COG0463	Glycosyl transferase, family 2
HC645_RS00905	COG2861	carbohydrate metabolic process
HC645_RS00910	COG4942	peptidase
HC645_RS00920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC645_RS00925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC645_RS00945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC645_RS00955	COG2186	Transcriptional regulator
HC645_RS00975	COG3722	fumarate hydratase activity
HC645_RS00990	COG0625	glutathione transferase activity
HC645_RS01000	COG3276	selenocysteine insertion sequence binding
HC645_RS01005	COG1414	Transcriptional regulator
HC645_RS01010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC645_RS01015	COG3977	Valine--pyruvate aminotransferase
HC645_RS01020	COG0366	Alpha amylase catalytic
HC645_RS01025	COG2992	FlgJ-related protein
HC645_RS01030	COG2207	Transcriptional regulator
HC645_RS01030	COG1609	Transcriptional regulator
HC645_RS01035	COG4214	carbohydrate transport
HC645_RS01045	COG4213	ABC transporter substrate-binding protein
HC645_RS01060	COG4682	membrane
HC645_RS01065	COG4682	membrane
HC645_RS01070	COG3274	enterobacterial common antigen metabolic process
HC645_RS01120	COG1278	Cold shock
HC645_RS01125	COG2944	sequence-specific DNA binding
HC645_RS01130	COG2814	Major facilitator Superfamily
HC645_RS01150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS01160	COG1609	Transcriptional regulator
HC645_RS01170	COG2885	chlorophyll binding
HC645_RS01175	COG0243	molybdopterin cofactor binding
HC645_RS01180	COG0456	acetyltransferase
HC645_RS01185	COG2818	Glycosylase
HC645_RS01190	COG5571	outer membrane autotransporter
HC645_RS01195	COG2223	nitrite transmembrane transporter activity
HC645_RS01220	COG0747	negative chemotaxis
HC645_RS01225	COG0601	transmembrane transport
HC645_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC645_RS01235	COG0444	Belongs to the ABC transporter superfamily
HC645_RS01240	COG4608	Belongs to the ABC transporter superfamily
HC645_RS01255	COG2894	cell division
HC645_RS01265	COG1215	transferase activity, transferring glycosyl groups
HC645_RS01270	COG0457	Tetratricopeptide repeat
HC645_RS01285	COG2194	sulfuric ester hydrolase activity
HC645_RS01315	COG1215	transferase activity, transferring glycosyl groups
HC645_RS01320	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC645_RS01325	COG3118	belongs to the thioredoxin family
HC645_RS01325	COG0457	Tetratricopeptide repeat
HC645_RS01330	COG2200	EAL domain
HC645_RS01330	COG2199	diguanylate cyclase activity
HC645_RS01340	COG0612	Peptidase, M16
HC645_RS01355	COG2982	Protein involved in outer membrane biogenesis
HC645_RS01360	COG0477	Major facilitator Superfamily
HC645_RS01365	COG1295	ribonuclease BN
HC645_RS01370	COG0583	DNA-binding transcription factor activity
HC645_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS01380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC645_RS01390	COG1454	alcohol dehydrogenase
HC645_RS01400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC645_RS01405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HC645_RS01410	COG0671	phosphoesterase, PA-phosphatase related
HC645_RS01430	COG0589	response to stress
HC645_RS01440	COG0306	phosphate transporter
HC645_RS01445	COG2081	HI0933 family
HC645_RS01450	COG2239	Acts as a magnesium transporter
HC645_RS01460	COG1124	(ABC) transporter
HC645_RS01470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC645_RS01475	COG0601	transmembrane transport
HC645_RS01480	COG0747	negative chemotaxis
HC645_RS01490	COG3479	Phenolic acid decarboxylase
HC645_RS01530	COG0628	permease
HC645_RS01535	COG0477	Major facilitator Superfamily
HC645_RS01545	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC645_RS01560	COG3714	YhhN family
HC645_RS01570	COG3776	membrane
HC645_RS01575	COG0742	ribosomal rna small subunit methyltransferase
HC645_RS01580	COG0552	protein localization to endoplasmic reticulum
HC645_RS01585	COG2884	Cell division ATP-binding protein ftsE
HC645_RS01590	COG2177	Part of the ABC transporter FtsEX involved in
HC645_RS01605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC645_RS01615	COG0683	leucine binding
HC645_RS01625	COG0683	leucine binding
HC645_RS01630	COG0559	Belongs to the binding-protein-dependent transport system permease family
HC645_RS01680	COG0584	glycerophosphoryl diester phosphodiesterase
HC645_RS01690	COG0405	Gamma-glutamyltransferase
HC645_RS01695	COG1247	-acetyltransferase
HC645_RS01705	COG0673	inositol 2-dehydrogenase activity
HC645_RS01710	COG1741	Belongs to the pirin family
HC645_RS01715	COG1609	Transcriptional regulator
HC645_RS01720	COG3265	gluconokinase activity
HC645_RS01725	COG2610	gluconate transmembrane transporter activity
HC645_RS01735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC645_RS01760	COG0058	SHG alpha-glucan phosphorylase activity
HC645_RS01775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC645_RS01790	COG1349	DNA-binding transcription factor activity
HC645_RS01800	COG0058	SHG alpha-glucan phosphorylase activity
HC645_RS01805	COG1640	4-alpha-glucanotransferase
HC645_RS01810	COG2610	gluconate transmembrane transporter activity
HC645_RS01820	COG1040	competence protein
HC645_RS01845	COG1918	ferrous iron import across plasma membrane
HC645_RS01850	COG2183	response to ionizing radiation
HC645_RS01855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC645_RS01860	COG0745	RESPONSE REGULATOR receiver
HC645_RS01880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC645_RS01885	COG1011	Hydrolase
HC645_RS01895	COG0494	nUDIX hydrolase
HC645_RS01900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HC645_RS01925	COG4796	Type ii and iii secretion system protein
HC645_RS01940	COG3266	domain, Protein
HC645_RS01945	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC645_RS01950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC645_RS01975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC645_RS01985	COG0402	S-adenosylhomocysteine deaminase activity
HC645_RS01990	COG0738	Major facilitator superfamily
HC645_RS02015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC645_RS02020	COG1289	transmembrane transporter activity
HC645_RS02030	COG1765	OsmC-like protein
HC645_RS02035	COG3954	Phosphoribulokinase
HC645_RS02045	COG0429	hydrolase of the alpha beta-hydrolase fold
HC645_RS02055	COG0488	(ABC) transporter
HC645_RS02070	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HC645_RS02075	COG1047	Peptidyl-prolyl cis-trans
HC645_RS02085	COG0545	Peptidyl-prolyl cis-trans isomerase
HC645_RS02090	COG2964	Protein conserved in bacteria
HC645_RS02145	COG0051	transcription antitermination factor activity, RNA binding
HC645_RS02170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HC645_RS02185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC645_RS02250	COG0201	protein transport
HC645_RS02275	COG0202	RNA polymerase activity
HC645_RS02290	COG0789	Transcriptional regulator
HC645_RS02295	COG3036	rescue of stalled ribosome
HC645_RS02325	COG0758	DNA mediated transformation
HC645_RS02335	COG0551	DNA topoisomerase type I activity
HC645_RS02355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC645_RS02390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC645_RS02395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS02400	COG1309	transcriptional regulator
HC645_RS02420	COG4145	pantothenate transmembrane transporter activity
HC645_RS02425	COG3924	membrane
HC645_RS02430	COG0439	Biotin carboxylase
HC645_RS02435	COG0511	ligase activity, forming carbon-carbon bonds
HC645_RS02460	COG2199	diguanylate cyclase activity
HC645_RS02460	COG2200	EAL domain
HC645_RS02465	COG1077	Cell shape determining protein MreB Mrl
HC645_RS02470	COG1792	Involved in formation and maintenance of cell shape
HC645_RS02475	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC645_RS02485	COG1530	ribonuclease E activity
HC645_RS02490	COG3164	Protein of unknown function
HC645_RS02495	COG0312	modulator of DNA gyrase
HC645_RS02500	COG0583	DNA-binding transcription factor activity
HC645_RS02515	COG1289	transmembrane transporter activity
HC645_RS02520	COG2732	(Barnase) inhibitor
HC645_RS02545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC645_RS02550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC645_RS02555	COG3105	Protein conserved in bacteria
HC645_RS02560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HC645_RS02580	COG0625	glutathione transferase activity
HC645_RS02585	COG2969	positive regulation of protein catabolic process
HC645_RS02595	COG0493	'glutamate synthase
HC645_RS02600	COG0067	glutamate synthase
HC645_RS02600	COG0070	glutamate synthase
HC645_RS02600	COG0069	glutamate synthase activity
HC645_RS02605	COG1242	4 iron, 4 sulfur cluster binding
HC645_RS02610	COG2271	Major facilitator Superfamily
HC645_RS02615	COG1063	alcohol dehydrogenase
HC645_RS02625	COG1312	Catalyzes the dehydration of D-mannonate
HC645_RS02630	COG5002	protein histidine kinase activity
HC645_RS02630	COG2198	Histidine kinase
HC645_RS02630	COG0784	Response regulator, receiver
HC645_RS02635	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HC645_RS02640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC645_RS02645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS02655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS02660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC645_RS02665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC645_RS02670	COG1137	ATPase activity
HC645_RS02675	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HC645_RS02680	COG3117	lipopolysaccharide transmembrane transporter activity
HC645_RS02685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HC645_RS02695	COG0530	calcium, potassium:sodium antiporter activity
HC645_RS02700	COG1127	ABC transporter
HC645_RS02705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HC645_RS02710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HC645_RS02715	COG2854	intermembrane phospholipid transfer
HC645_RS02720	COG3113	response to antibiotic
HC645_RS02725	COG5007	Belongs to the BolA IbaG family
HC645_RS02735	COG3423	Transcriptional regulator
HC645_RS02740	COG0142	geranyltranstransferase activity
HC645_RS02755	COG0697	spore germination
HC645_RS02765	COG2027	D-alanyl-D-alanine carboxypeptidase
HC645_RS02775	COG1534	Rna-binding protein
HC645_RS02785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC645_RS02790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC645_RS02800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC645_RS02845	COG0195	Participates in both transcription termination and antitermination
HC645_RS02890	COG0814	amino acid
HC645_RS02895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC645_RS02900	COG0826	peptidase U32
HC645_RS02905	COG0826	peptidase U32
HC645_RS02910	COG3154	lipid carrier protein
HC645_RS02915	COG3153	acetyltransferase
HC645_RS02930	COG0693	protein deglycase activity
HC645_RS02935	COG0702	epimerase
HC645_RS02940	COG0701	Predicted permease
HC645_RS02945	COG2823	Periplasmic or secreted lipoprotein
HC645_RS02965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC645_RS02970	COG2721	sulfolactate sulfo-lyase activity
HC645_RS02980	COG2271	Major facilitator Superfamily
HC645_RS02990	COG2084	Dehydrogenase
HC645_RS02995	COG1929	Belongs to the glycerate kinase type-1 family
HC645_RS03025	COG1741	Belongs to the pirin family
HC645_RS03030	COG0583	DNA-binding transcription factor activity
HC645_RS03035	COG3152	Membrane
HC645_RS03040	COG0435	Glutathione S-transferase
HC645_RS03045	COG2259	Doxx family
HC645_RS03055	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HC645_RS03060	COG4575	ribosome binding
HC645_RS03065	COG1422	Protein of unknown function (DUF1090)
HC645_RS03075	COG0586	Pfam SNARE associated Golgi protein
HC645_RS03080	COG2186	Transcriptional regulator
HC645_RS03085	COG2271	Major facilitator Superfamily
HC645_RS03095	COG2721	sulfolactate sulfo-lyase activity
HC645_RS03110	COG0861	Integral membrane protein TerC family
HC645_RS03115	COG0673	inositol 2-dehydrogenase activity
HC645_RS03120	COG1451	nucleotide metabolic process
HC645_RS03140	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC645_RS03140	COG1902	pentaerythritol trinitrate reductase activity
HC645_RS03190	COG1695	Transcriptional regulator
HC645_RS03200	COG2375	cellular response to nickel ion
HC645_RS03215	COG1461	Dihydroxyacetone kinase
HC645_RS03220	COG2376	Dihydroxyacetone kinase
HC645_RS03290	COG3247	response to pH
HC645_RS03300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS03300	COG2205	protein histidine kinase activity
HC645_RS03300	COG2198	Histidine kinase
HC645_RS03300	COG0784	Response regulator, receiver
HC645_RS03305	COG2197	response regulator
HC645_RS03330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC645_RS03335	COG0358	DNA primase activity
HC645_RS03340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HC645_RS03405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC645_RS03420	COG4991	sh3 domain protein
HC645_RS03425	COG3025	triphosphatase activity
HC645_RS03450	COG2960	long-chain fatty acid transporting porin activity
HC645_RS03465	COG3384	dioxygenase
HC645_RS03470	COG0754	glutathionylspermidine amidase activity
HC645_RS03485	COG0494	nUDIX hydrolase
HC645_RS03490	COG3151	Protein conserved in bacteria
HC645_RS03495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC645_RS03500	COG3150	esterase
HC645_RS03510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC645_RS03515	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC645_RS03520	COG0642	Histidine kinase
HC645_RS03530	COG3111	PFAM Bacterial OB fold (BOF) protein
HC645_RS03535	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HC645_RS03540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC645_RS03545	COG0204	Acyl-transferase
HC645_RS03550	COG2132	Multicopper oxidase
HC645_RS03555	COG1032	radical SAM domain protein
HC645_RS03565	COG0656	L-ascorbic acid biosynthetic process
HC645_RS03570	COG1979	alcohol dehydrogenase
HC645_RS03575	COG2207	Transcriptional regulator
HC645_RS03580	COG0586	Pfam SNARE associated Golgi protein
HC645_RS03585	COG0626	cystathionine gamma-synthase activity
HC645_RS03600	COG0848	biopolymer transport protein
HC645_RS03605	COG2211	Major facilitator Superfamily
HC645_RS03630	COG0625	glutathione transferase activity
HC645_RS03645	COG0754	glutathionylspermidine amidase activity
HC645_RS03650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC645_RS03670	COG0583	DNA-binding transcription factor activity
HC645_RS03675	COG0626	cystathionine gamma-synthase activity
HC645_RS03690	COG1811	Na channel or pump
HC645_RS03695	COG1982	Orn Lys Arg decarboxylase major
HC645_RS03700	COG2211	Major facilitator Superfamily
HC645_RS03715	COG1194	a g-specific adenine glycosylase
HC645_RS03725	COG3171	Protein conserved in bacteria
HC645_RS03735	COG4214	carbohydrate transport
HC645_RS03750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC645_RS03765	COG0762	integral membrane protein
HC645_RS03770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC645_RS03775	COG2805	Type II/IV secretion system protein
HC645_RS03800	COG0189	ligase activity
HC645_RS03805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC645_RS03810	COG2356	endonuclease I
HC645_RS03820	COG2814	Major facilitator Superfamily
HC645_RS03860	COG0501	Belongs to the peptidase M48B family
HC645_RS03865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC645_RS03880	COG0191	fructose-bisphosphate aldolase activity
HC645_RS03885	COG0668	transmembrane transport
HC645_RS03895	COG2968	Membrane
HC645_RS03915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC645_RS03920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC645_RS03940	COG0006	proline dipeptidase activity
HC645_RS03945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC645_RS03950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC645_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS03975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC645_RS03995	COG2723	6-phospho-beta-galactosidase activity
HC645_RS04000	COG1737	Transcriptional regulator
HC645_RS04010	COG1272	protein, Hemolysin III
HC645_RS04020	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HC645_RS04030	COG0716	FMN binding
HC645_RS04035	COG4974	Belongs to the 'phage' integrase family
HC645_RS04045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC645_RS04070	COG4942	peptidase
HC645_RS04080	COG2814	Major facilitator Superfamily
HC645_RS04095	COG0667	Aldo Keto reductase
HC645_RS04135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC645_RS04140	COG1393	Belongs to the ArsC family
HC645_RS04145	COG3104	oligopeptide transport
HC645_RS04155	COG1538	Outer membrane efflux protein
HC645_RS04160	COG1289	transmembrane transporter activity
HC645_RS04175	COG3592	Divergent 4Fe-4S mono-cluster
HC645_RS04180	COG2388	GCN5-related N-acetyl-transferase
HC645_RS04190	COG3539	Fimbrial protein
HC645_RS04195	COG3539	Fimbrial protein
HC645_RS04200	COG3539	Fimbrial protein
HC645_RS04205	COG3188	usher protein
HC645_RS04210	COG3121	Chaperone
HC645_RS04215	COG3539	Fimbrial protein
HC645_RS04230	COG4974	Belongs to the 'phage' integrase family
HC645_RS04235	COG0582	viral genome integration into host DNA
HC645_RS04240	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HC645_RS04245	COG1846	Transcriptional regulator
HC645_RS04250	COG0697	spore germination
HC645_RS04300	COG0667	Aldo Keto reductase
HC645_RS04305	COG0814	amino acid
HC645_RS04320	COG0183	Belongs to the thiolase family
HC645_RS04330	COG0823	Involved in the tonB-independent uptake of proteins
HC645_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS04345	COG2814	Major facilitator Superfamily
HC645_RS04380	COG3842	ATPase activity
HC645_RS04385	COG0395	ABC-type sugar transport system, permease component
HC645_RS04390	COG1175	transmembrane transport
HC645_RS04395	COG1917	Cupin 2, conserved barrel domain protein
HC645_RS04400	COG1794	racemase activity, acting on amino acids and derivatives
HC645_RS04405	COG0583	DNA-binding transcription factor activity
HC645_RS04415	COG1609	Transcriptional regulator
HC645_RS04420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS04425	COG2723	6-phospho-beta-galactosidase activity
HC645_RS04430	COG2186	Transcriptional regulator
HC645_RS04440	COG1609	Transcriptional regulator
HC645_RS04455	COG0667	Aldo Keto reductase
HC645_RS04465	COG0861	Integral membrane protein TerC family
HC645_RS04500	COG2165	general secretion pathway protein
HC645_RS04505	COG4795	General secretion pathway protein
HC645_RS04515	COG4967	type IV pilus modification protein PilV
HC645_RS04520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HC645_RS04525	COG1025	Belongs to the peptidase M16 family
HC645_RS04535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC645_RS04545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC645_RS04545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HC645_RS04550	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC645_RS04555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC645_RS04585	COG4656	Part of a membrane complex involved in electron transport
HC645_RS04590	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS04590	COG1454	alcohol dehydrogenase
HC645_RS04785	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HC645_RS04790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC645_RS04795	COG2166	iron-sulfur cluster assembly
HC645_RS04800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC645_RS04810	COG0583	DNA-binding transcription factor activity
HC645_RS04815	COG2363	Small membrane protein
HC645_RS04825	COG1349	DNA-binding transcription factor activity
HC645_RS04845	COG0738	Major facilitator superfamily
HC645_RS04855	COG0235	Class ii aldolase
HC645_RS04860	COG1454	alcohol dehydrogenase
HC645_RS04880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC645_RS04895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC645_RS04900	COG2011	ABC-type metal ion transport system permease component
HC645_RS04905	COG1464	Belongs to the NlpA lipoprotein family
HC645_RS04910	COG0477	Major facilitator Superfamily
HC645_RS04920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC645_RS04925	COG1760	l-serine dehydratase
HC645_RS04930	COG0814	amino acid
HC645_RS04935	COG1611	Belongs to the LOG family
HC645_RS04950	COG3098	single-species biofilm formation
HC645_RS04955	COG0564	pseudouridine synthase activity
HC645_RS04960	COG0716	FMN binding
HC645_RS04965	COG2271	Major facilitator Superfamily
HC645_RS04970	COG4948	Mandelate Racemase Muconate Lactonizing
HC645_RS04975	COG4948	Mandelate Racemase Muconate Lactonizing
HC645_RS04980	COG1929	Belongs to the glycerate kinase type-1 family
HC645_RS04985	COG3850	Histidine kinase
HC645_RS04985	COG4999	Histidine kinase
HC645_RS04985	COG2205	protein histidine kinase activity
HC645_RS04985	COG3437	response regulator, receiver
HC645_RS04995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC645_RS05000	COG3956	TIGRFAM MazG family protein
HC645_RS05025	COG0602	queuosine metabolic process
HC645_RS05030	COG0720	synthase
HC645_RS05050	COG2234	aminopeptidase activity
HC645_RS05110	COG4942	peptidase
HC645_RS05110	COG1388	LysM domain
HC645_RS05115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC645_RS05140	COG0163	prenyltransferase activity
HC645_RS05145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC645_RS05185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS05190	COG4558	Periplasmic binding protein
HC645_RS05195	COG3720	iron ion transport
HC645_RS05215	COG0679	Auxin Efflux Carrier
HC645_RS05230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC645_RS05235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC645_RS05240	COG1121	(ABC) transporter
HC645_RS05250	COG1609	Transcriptional regulator
HC645_RS05255	COG1940	carbohydrate kinase activity
HC645_RS05260	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC645_RS05265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS05270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS05275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS05280	COG4580	involved in the transport of maltose and maltodextrins
HC645_RS05290	COG2723	6-phospho-beta-galactosidase activity
HC645_RS05300	COG0309	Hydrogenase expression formation protein (HypE)
HC645_RS05305	COG0409	Hydrogenase expression formation protein
HC645_RS05310	COG0298	carbon dioxide binding
HC645_RS05315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HC645_RS05330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC645_RS05335	COG0651	ATP synthesis coupled electron transport
HC645_RS05340	COG0650	Formate hydrogenlyase subunit 4
HC645_RS05345	COG3261	NADH dehydrogenase
HC645_RS05345	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HC645_RS05350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC645_RS05355	COG3260	NADH ubiquinone oxidoreductase 20
HC645_RS05365	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC645_RS05375	COG2723	6-phospho-beta-galactosidase activity
HC645_RS05380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS05380	COG1263	PTS System
HC645_RS05390	COG1609	Transcriptional regulator
HC645_RS05395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC645_RS05400	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HC645_RS05405	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HC645_RS05435	COG1349	DNA-binding transcription factor activity
HC645_RS05440	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS05455	COG3732	PTS system glucitol sorbitol-specific
HC645_RS05460	COG3730	PTS system glucitol sorbitol-specific
HC645_RS05465	COG2951	lytic endotransglycosylase activity
HC645_RS05470	COG1121	(ABC) transporter
HC645_RS05475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC645_RS05485	COG1546	Belongs to the CinA family
HC645_RS05505	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC645_RS05535	COG2823	Periplasmic or secreted lipoprotein
HC645_RS05540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC645_RS05545	COG1238	metal cluster binding
HC645_RS05565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC645_RS05570	COG2814	Major facilitator Superfamily
HC645_RS05575	COG1566	PFAM secretion protein HlyD family protein
HC645_RS05585	COG1846	Transcriptional regulator
HC645_RS05600	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HC645_RS05610	COG4176	ABC-type proline glycine betaine transport system permease component
HC645_RS05625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC645_RS05635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC645_RS05640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC645_RS05645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC645_RS05650	COG4575	ribosome binding
HC645_RS05670	COG2916	Histone family protein nucleoid-structuring protein H-NS
HC645_RS05685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC645_RS05690	COG0640	Transcriptional regulator
HC645_RS05700	COG0583	DNA-binding transcription factor activity
HC645_RS05705	COG3284	Transcriptional regulator
HC645_RS05710	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS05715	COG3539	Fimbrial protein
HC645_RS05720	COG3121	Chaperone
HC645_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS05765	COG0235	Class ii aldolase
HC645_RS05775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS05810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS05815	COG2207	Transcriptional regulator
HC645_RS05815	COG3708	Transcriptional regulator
HC645_RS05870	COG0582	viral genome integration into host DNA
HC645_RS05885	COG2867	negative regulation of translational initiation
HC645_RS05905	COG0497	DNA recombination
HC645_RS05920	COG4536	flavin adenine dinucleotide binding
HC645_RS05925	COG4137	Cytochrome C assembly protein
HC645_RS05930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC645_RS05970	COG2885	chlorophyll binding
HC645_RS05975	COG2199	diguanylate cyclase activity
HC645_RS05985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC645_RS05990	COG1605	Chorismate mutase
HC645_RS05990	COG0287	Prephenate dehydrogenase
HC645_RS06000	COG0077	Prephenate dehydratase
HC645_RS06000	COG1605	Chorismate mutase
HC645_RS06010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC645_RS06015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC645_RS06030	COG0542	response to heat
HC645_RS06055	COG0477	Major facilitator Superfamily
HC645_RS06060	COG5544	Lipoprotein
HC645_RS06065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC645_RS06080	COG3118	belongs to the thioredoxin family
HC645_RS06085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC645_RS06100	COG0513	Belongs to the DEAD box helicase family
HC645_RS06110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC645_RS06125	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HC645_RS06130	COG3026	antisigma factor binding
HC645_RS06135	COG3086	response to oxidative stress
HC645_RS06145	COG0681	Belongs to the peptidase S26 family
HC645_RS06165	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HC645_RS06175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC645_RS06180	COG1737	Transcriptional regulator
HC645_RS06185	COG0560	Phosphoserine phosphatase
HC645_RS06200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC645_RS06200	COG0047	phosphoribosylformylglycinamidine synthase activity
HC645_RS06205	COG2205	protein histidine kinase activity
HC645_RS06210	COG3170	Tfp pilus assembly protein FimV
HC645_RS06215	COG2204	response regulator
HC645_RS06220	COG0347	Belongs to the P(II) protein family
HC645_RS06225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC645_RS06225	COG1017	nitric oxide dioxygenase activity
HC645_RS06235	COG2259	Doxx family
HC645_RS06240	COG1940	carbohydrate kinase activity
HC645_RS06245	COG0457	Tetratricopeptide repeat
HC645_RS06250	COG0477	Major facilitator Superfamily
HC645_RS06250	COG2814	Major facilitator Superfamily
HC645_RS06255	COG2017	converts alpha-aldose to the beta-anomer
HC645_RS06260	COG2814	Major facilitator Superfamily
HC645_RS06265	COG3711	transcriptional antiterminator
HC645_RS06270	COG3683	transport system, periplasmic component
HC645_RS06275	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HC645_RS06305	COG0822	iron-sulfur transferase activity
HC645_RS06325	COG0633	Ferredoxin
HC645_RS06330	COG2975	iron-sulfur cluster assembly
HC645_RS06350	COG2897	thiosulfate sulfurtransferase activity
HC645_RS06355	COG2373	Large extracellular alpha-helical protein
HC645_RS06360	COG4953	penicillin-binding protein 1C
HC645_RS06390	COG2976	Protein conserved in bacteria
HC645_RS06410	COG1645	bacterial-type flagellum-dependent swarming motility
HC645_RS06420	COG0516	GMP reductase activity
HC645_RS06420	COG0517	IMP dehydrogenase activity
HC645_RS06430	COG3119	arylsulfatase activity
HC645_RS06435	COG0641	radical SAM
HC645_RS06455	COG2200	EAL domain
HC645_RS06470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC645_RS06485	COG2723	6-phospho-beta-galactosidase activity
HC645_RS06495	COG2233	PERMEase
HC645_RS06510	COG1393	Belongs to the ArsC family
HC645_RS06515	COG4783	chaperone-mediated protein folding
HC645_RS06525	COG0628	permease
HC645_RS06530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC645_RS06535	COG2716	regulation of RNA biosynthetic process
HC645_RS06545	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HC645_RS06555	COG2321	neutral zinc metallopeptidase
HC645_RS06560	COG1444	tRNA N-acetyltransferase activity
HC645_RS06565	COG0400	carboxylic ester hydrolase activity
HC645_RS06580	COG1393	Belongs to the ArsC family
HC645_RS06590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC645_RS06595	COG0493	'glutamate synthase
HC645_RS06595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC645_RS06605	COG5342	invasion associated locus B
HC645_RS06610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC645_RS06615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC645_RS06625	COG4810	utilization protein
HC645_RS06715	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC645_RS06735	COG2837	iron assimilation
HC645_RS06745	COG4150	thiosulfate binding
HC645_RS06750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HC645_RS06755	COG4208	sulfate ABC transporter
HC645_RS06760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HC645_RS06770	COG4319	ketosteroid isomerase
HC645_RS06810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC645_RS06830	COG3530	Putative quorum-sensing-regulated virulence factor
HC645_RS06835	COG0385	Bile acid
HC645_RS06840	COG0583	DNA-binding transcription factor activity
HC645_RS06870	COG3415	Transposase
HC645_RS06875	COG3415	Transposase
HC645_RS06885	COG2200	EAL domain
HC645_RS06885	COG2199	diguanylate cyclase activity
HC645_RS06890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC645_RS06905	COG0667	Aldo Keto reductase
HC645_RS06910	COG3961	Belongs to the TPP enzyme family
HC645_RS06925	COG3279	Response regulator of the LytR AlgR family
HC645_RS06930	COG3275	phosphorelay sensor kinase activity
HC645_RS06945	COG0436	Aminotransferase
HC645_RS06955	COG2807	transmembrane transport
HC645_RS06965	COG0583	DNA-binding transcription factor activity
HC645_RS06985	COG0582	viral genome integration into host DNA
HC645_RS07040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC645_RS07045	COG4197	protein conserved in bacteria, prophage-related
HC645_RS07060	COG1061	Type III restriction enzyme res subunit
HC645_RS07095	COG3179	chitinase
HC645_RS07140	COG1484	DNA-dependent DNA replication
HC645_RS07145	COG4584	PFAM Integrase catalytic
HC645_RS07250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC645_RS07250	COG2755	lipolytic protein G-D-S-L family
HC645_RS07265	COG2116	formate transmembrane transporter activity
HC645_RS07270	COG2853	Lipoprotein
HC645_RS07280	COG3691	Protein conserved in bacteria
HC645_RS07295	COG2062	phosphohistidine phosphatase, SixA
HC645_RS07320	COG0730	response to heat
HC645_RS07325	COG3101	peptidyl-lysine hydroxylation
HC645_RS07340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC645_RS07360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC645_RS07370	COG0586	Pfam SNARE associated Golgi protein
HC645_RS07380	COG0285	dihydrofolate synthase activity
HC645_RS07385	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HC645_RS07390	COG1286	toxin biosynthetic process
HC645_RS07395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC645_RS07400	COG0163	prenyltransferase activity
HC645_RS07425	COG4160	amino acid transport
HC645_RS07430	COG4598	ABC transporter
HC645_RS07445	COG1090	epimerase
HC645_RS07450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC645_RS07455	COG0625	glutathione transferase activity
HC645_RS07460	COG0625	glutathione transferase activity
HC645_RS07465	COG0622	Phosphoesterase
HC645_RS07470	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HC645_RS07475	COG0857	belongs to the CobB CobQ family
HC645_RS07475	COG0280	phosphate acetyltransferase
HC645_RS07495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC645_RS07500	COG0490	domain, Protein
HC645_RS07500	COG0471	metal ion transport
HC645_RS07510	COG0436	Aminotransferase
HC645_RS07515	COG0583	DNA-binding transcription factor activity
HC645_RS07565	COG0839	Belongs to the complex I subunit 6 family
HC645_RS07575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC645_RS07580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC645_RS07595	COG2153	protein acetylation
HC645_RS07600	COG1169	isochorismate synthase
HC645_RS07625	COG0318	PFAM AMP-dependent synthetase and ligase
HC645_RS07635	COG5464	transposase or invertase
HC645_RS07655	COG1414	Transcriptional regulator
HC645_RS07665	COG2271	Major facilitator Superfamily
HC645_RS07675	COG0247	lactate metabolic process
HC645_RS07685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC645_RS07690	COG2271	Major facilitator Superfamily
HC645_RS07695	COG0584	glycerophosphoryl diester phosphodiesterase
HC645_RS07700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC645_RS07725	COG2205	protein histidine kinase activity
HC645_RS07725	COG0784	Response regulator, receiver
HC645_RS07735	COG0642	Histidine kinase
HC645_RS07735	COG2198	Histidine kinase
HC645_RS07750	COG2169	Transcriptional regulator
HC645_RS07750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC645_RS07755	COG3145	DNA-N1-methyladenine dioxygenase activity
HC645_RS07760	COG4615	Cyclic peptide transporter
HC645_RS07765	COG2239	Acts as a magnesium transporter
HC645_RS07770	COG0659	secondary active sulfate transmembrane transporter activity
HC645_RS07785	COG0628	permease
HC645_RS07810	COG1349	DNA-binding transcription factor activity
HC645_RS07815	COG0494	nUDIX hydrolase
HC645_RS07835	COG1061	Type III restriction enzyme res subunit
HC645_RS07840	COG1187	pseudouridine synthase activity
HC645_RS07845	COG2814	Major facilitator Superfamily
HC645_RS07855	COG4172	Belongs to the ABC transporter superfamily
HC645_RS07860	COG4239	(ABC) transporter, permease
HC645_RS07865	COG4174	ABC transporter (Permease)
HC645_RS07870	COG4166	transmembrane transport
HC645_RS07875	COG2200	EAL domain
HC645_RS07880	COG0791	NLP P60 protein
HC645_RS07885	COG0671	phosphoesterase, PA-phosphatase related
HC645_RS07890	COG0523	cobalamin synthesis protein
HC645_RS07895	COG0246	Mannitol dehydrogenase
HC645_RS07900	COG1312	Catalyzes the dehydration of D-mannonate
HC645_RS07920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS07920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS07925	COG1105	Belongs to the carbohydrate kinase PfkB family
HC645_RS07930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HC645_RS07930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC645_RS07930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC645_RS07940	COG2855	membrane
HC645_RS07945	COG0583	DNA-binding transcription factor activity
HC645_RS07950	COG0833	amino acid
HC645_RS07955	COG4771	TonB-dependent receptor
HC645_RS07970	COG2311	Membrane
HC645_RS07985	COG1129	ABC transporter
HC645_RS07995	COG2949	membrane
HC645_RS08005	COG1346	cytolysis
HC645_RS08015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC645_RS08020	COG3659	wide pore channel activity
HC645_RS08035	COG2723	6-phospho-beta-galactosidase activity
HC645_RS08040	COG1538	Outer membrane efflux protein
HC645_RS08045	COG0586	Pfam SNARE associated Golgi protein
HC645_RS08055	COG1686	Belongs to the peptidase S11 family
HC645_RS08070	COG0277	FAD linked oxidase domain protein
HC645_RS08075	COG1472	Belongs to the glycosyl hydrolase 3 family
HC645_RS08080	COG1732	Glycine betaine
HC645_RS08085	COG1174	glycine betaine transport
HC645_RS08090	COG1125	glycine betaine transport
HC645_RS08095	COG1174	glycine betaine transport
HC645_RS08105	COG3275	phosphorelay sensor kinase activity
HC645_RS08115	COG4807	Protein conserved in bacteria
HC645_RS08135	COG5455	response to cobalt ion
HC645_RS08140	COG0583	DNA-binding transcription factor activity
HC645_RS08145	COG2252	PERMEase
HC645_RS08155	COG0583	DNA-binding transcription factor activity
HC645_RS08165	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HC645_RS08200	COG0351	phosphomethylpyrimidine kinase
HC645_RS08205	COG1830	Aldolase
HC645_RS08215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC645_RS08240	COG1070	Carbohydrate kinase
HC645_RS08250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC645_RS08255	COG4948	Mandelate Racemase Muconate Lactonizing
HC645_RS08260	COG0747	negative chemotaxis
HC645_RS08265	COG0601	transmembrane transport
HC645_RS08275	COG0444	Belongs to the ABC transporter superfamily
HC645_RS08280	COG4608	Belongs to the ABC transporter superfamily
HC645_RS08295	COG0745	RESPONSE REGULATOR receiver
HC645_RS08300	COG2205	protein histidine kinase activity
HC645_RS08325	COG1301	dicarboxylic acid transport
HC645_RS08345	COG5002	protein histidine kinase activity
HC645_RS08350	COG0443	Heat shock 70 kDa protein
HC645_RS08355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC645_RS08370	COG2982	Protein involved in outer membrane biogenesis
HC645_RS08375	COG1253	flavin adenine dinucleotide binding
HC645_RS08430	COG0110	maltose O-acetyltransferase activity
HC645_RS08435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HC645_RS08440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC645_RS08445	COG1051	belongs to the nudix hydrolase family
HC645_RS08450	COG0297	glycogen (starch) synthase activity
HC645_RS08520	COG0438	transferase activity, transferring glycosyl groups
HC645_RS08525	COG1442	glycosyl transferase family 8
HC645_RS08525	COG1216	Glycosyl transferase, family 2
HC645_RS08535	COG0463	Glycosyl transferase, family 2
HC645_RS08560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC645_RS08590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC645_RS08595	COG0583	DNA-binding transcription factor activity
HC645_RS08605	COG0531	amino acid
HC645_RS08610	COG0640	Transcriptional regulator
HC645_RS08615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC645_RS08620	COG2925	Exonuclease
HC645_RS08635	COG1289	transmembrane transporter activity
HC645_RS08655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HC645_RS08665	COG1942	4-Oxalocrotonate Tautomerase
HC645_RS08670	COG0583	DNA-binding transcription factor activity
HC645_RS08675	COG0095	Lipoate-protein ligase
HC645_RS08680	COG0477	Major facilitator Superfamily
HC645_RS08690	COG5001	Diguanylate cyclase
HC645_RS08690	COG3300	MHYT domain
HC645_RS08700	COG3615	Tellurite resistance protein tehB
HC645_RS08725	COG3706	GGDEF domain
HC645_RS08750	COG0534	Mate efflux family protein
HC645_RS08760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC645_RS08780	COG0604	alcohol dehydrogenase
HC645_RS08785	COG1309	transcriptional regulator
HC645_RS08790	COG0025	NhaP-type Na H and K H
HC645_RS08825	COG0251	oxidation-reduction process
HC645_RS08845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HC645_RS08860	COG1418	mRNA catabolic process
HC645_RS08865	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC645_RS08870	COG3727	T/G mismatch-specific endonuclease activity
HC645_RS08875	COG0697	spore germination
HC645_RS08880	COG2354	Protein conserved in bacteria
HC645_RS08910	COG0366	Alpha amylase catalytic
HC645_RS08935	COG2197	response regulator
HC645_RS08945	COG2197	response regulator
HC645_RS08980	COG3012	SEC-C Motif Domain Protein
HC645_RS08980	COG3318	Belongs to the UPF0149 family
HC645_RS08985	COG0814	amino acid
HC645_RS08995	COG1528	Iron-storage protein
HC645_RS09010	COG0477	Major facilitator Superfamily
HC645_RS09020	COG2211	Major facilitator Superfamily
HC645_RS09030	COG1528	Iron-storage protein
HC645_RS09040	COG1879	ABC-type sugar transport system periplasmic component
HC645_RS09050	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS09075	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC645_RS09085	COG3102	Protein conserved in bacteria
HC645_RS09105	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HC645_RS09110	COG1801	Protein of unknown function DUF72
HC645_RS09115	COG1335	isochorismatase
HC645_RS09125	COG0494	nUDIX hydrolase
HC645_RS09150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC645_RS09160	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HC645_RS09165	COG0739	heme binding
HC645_RS09170	COG1560	Kdo2-lipid A biosynthetic process
HC645_RS09180	COG1737	Transcriptional regulator
HC645_RS09190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC645_RS09195	COG0129	dihydroxy-acid dehydratase activity
HC645_RS09200	COG0800	Aldolase
HC645_RS09210	COG3141	response to X-ray
HC645_RS09215	COG2979	Protein of unknown function (DUF533)
HC645_RS09220	COG1770	oligopeptidase
HC645_RS09225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC645_RS09235	COG2372	response to copper ion
HC645_RS09240	COG1276	copper resistance
HC645_RS09255	COG2990	Protein conserved in bacteria
HC645_RS09280	COG3008	intermembrane lipid transfer
HC645_RS09285	COG2995	paraquat-inducible protein a
HC645_RS09290	COG1956	GAF domain-containing protein
HC645_RS09310	COG2814	Major facilitator Superfamily
HC645_RS09315	COG1414	Transcriptional regulator
HC645_RS09350	COG0768	penicillin binding
HC645_RS09355	COG2226	methyltransferase
HC645_RS09370	COG3716	PTS system mannose fructose sorbose family IID component
HC645_RS09375	COG3715	PTS system
HC645_RS09380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS09380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS09385	COG1253	flavin adenine dinucleotide binding
HC645_RS09390	COG2200	EAL domain
HC645_RS09400	COG1760	l-serine dehydratase
HC645_RS09430	COG1653	transport
HC645_RS09435	COG1175	transmembrane transport
HC645_RS09440	COG0395	ABC-type sugar transport system, permease component
HC645_RS09445	COG3842	ATPase activity
HC645_RS09455	COG0251	oxidation-reduction process
HC645_RS09460	COG1199	ATP-dependent helicase activity
HC645_RS09470	COG3065	identical protein binding
HC645_RS09480	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HC645_RS09490	COG2894	cell division
HC645_RS09505	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC645_RS09535	COG2719	SpoVR family
HC645_RS09560	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC645_RS09570	COG4774	siderophore transport
HC645_RS09585	COG2308	Evidence 4 Homologs of previously reported genes of
HC645_RS09630	COG0583	DNA-binding transcription factor activity
HC645_RS09635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC645_RS09650	COG1882	Formate acetyltransferase
HC645_RS09685	COG0583	DNA-binding transcription factor activity
HC645_RS09715	COG0583	DNA-binding transcription factor activity
HC645_RS09730	COG3122	Protein conserved in bacteria
HC645_RS09755	COG2885	chlorophyll binding
HC645_RS09765	COG3501	Rhs element vgr protein
HC645_RS09770	COG1388	LysM domain
HC645_RS09835	COG0012	GTP binding
HC645_RS09855	COG0659	secondary active sulfate transmembrane transporter activity
HC645_RS09885	COG2890	protein-(glutamine-N5) methyltransferase activity
HC645_RS09905	COG0387	Pfam Sodium calcium exchanger
HC645_RS09910	COG4572	Cation transport regulator
HC645_RS09915	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC645_RS09925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HC645_RS09930	COG3707	response regulator
HC645_RS09940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC645_RS09950	COG1116	anion transmembrane transporter activity
HC645_RS09955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC645_RS09955	COG2146	nitrite reductase [NAD(P)H] activity
HC645_RS09960	COG0243	molybdopterin cofactor binding
HC645_RS09965	COG4932	domain protein
HC645_RS09970	COG2197	response regulator
HC645_RS09975	COG3850	Histidine kinase
HC645_RS09980	COG2223	nitrite transmembrane transporter activity
HC645_RS09990	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC645_RS09995	COG1140	nitrate reductase beta subunit
HC645_RS10000	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC645_RS10005	COG2181	nitrate reductase activity
HC645_RS10015	COG1522	sequence-specific DNA binding
HC645_RS10050	COG0788	formyltetrahydrofolate deformylase activity
HC645_RS10060	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC645_RS10065	COG0745	RESPONSE REGULATOR receiver
HC645_RS10070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC645_RS10075	COG2916	Histone family protein nucleoid-structuring protein H-NS
HC645_RS10085	COG1435	thymidine kinase activity
HC645_RS10090	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS10090	COG1454	alcohol dehydrogenase
HC645_RS10100	COG2095	MarC family integral membrane protein
HC645_RS10110	COG4166	transmembrane transport
HC645_RS10115	COG0601	transmembrane transport
HC645_RS10120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC645_RS10125	COG0444	Belongs to the ABC transporter superfamily
HC645_RS10135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC645_RS10155	COG2353	YceI-like domain
HC645_RS10165	COG2350	Protein conserved in bacteria
HC645_RS10175	COG3001	Fructosamine kinase
HC645_RS10185	COG1105	Belongs to the carbohydrate kinase PfkB family
HC645_RS10190	COG3137	Salt-induced outer membrane protein
HC645_RS10230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC645_RS10230	COG0072	phenylalanine-tRNA ligase activity
HC645_RS10250	COG0583	DNA-binding transcription factor activity
HC645_RS10270	COG0386	Belongs to the glutathione peroxidase family
HC645_RS10280	COG0791	NLP P60 protein
HC645_RS10290	COG4256	Hemin uptake protein
HC645_RS10295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC645_RS10310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC645_RS10310	COG0574	Belongs to the PEP-utilizing enzyme family
HC645_RS10320	COG0628	permease
HC645_RS10325	COG0277	FAD linked oxidase domain protein
HC645_RS10325	COG0247	lactate metabolic process
HC645_RS10330	COG2050	protein possibly involved in aromatic compounds catabolism
HC645_RS10335	COG2261	transglycosylase associated protein
HC645_RS10360	COG1120	ATPase activity
HC645_RS10365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS10375	COG0583	DNA-binding transcription factor activity
HC645_RS10400	COG1304	FMN binding
HC645_RS10415	COG0316	Belongs to the HesB IscA family
HC645_RS10420	COG0719	Fe-S assembly protein
HC645_RS10425	COG0396	ATPase activity
HC645_RS10430	COG0719	Fe-S assembly protein
HC645_RS10445	COG1376	ErfK ybiS ycfS ynhG family protein
HC645_RS10475	COG1309	transcriptional regulator
HC645_RS10485	COG2271	Major facilitator Superfamily
HC645_RS10490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC645_RS10515	COG1414	Transcriptional regulator
HC645_RS10550	COG2814	Major facilitator Superfamily
HC645_RS10570	COG0583	DNA-binding transcription factor activity
HC645_RS10575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC645_RS10595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC645_RS10600	COG1116	anion transmembrane transporter activity
HC645_RS10605	COG4774	siderophore transport
HC645_RS10610	COG1120	ATPase activity
HC645_RS10615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS10620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS10640	COG0765	amino acid transport
HC645_RS10645	COG1126	abc transporter atp-binding protein
HC645_RS10685	COG3383	formate dehydrogenase (NAD+) activity
HC645_RS10690	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HC645_RS10705	COG1175	transmembrane transport
HC645_RS10735	COG4133	protoheme IX ABC transporter activity
HC645_RS10740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC645_RS10745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC645_RS10760	COG1138	Cytochrome C-type biogenesis protein
HC645_RS10765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC645_RS10770	COG4235	cytochrome complex assembly
HC645_RS10770	COG3088	subunit of a heme lyase
HC645_RS10795	COG5002	protein histidine kinase activity
HC645_RS10795	COG3850	Histidine kinase
HC645_RS10800	COG0745	RESPONSE REGULATOR receiver
HC645_RS10815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC645_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS10855	COG2610	gluconate transmembrane transporter activity
HC645_RS10860	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC645_RS10870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC645_RS10880	COG0583	DNA-binding transcription factor activity
HC645_RS10910	COG2814	Major facilitator Superfamily
HC645_RS10940	COG0277	FAD linked oxidase domain protein
HC645_RS10945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC645_RS10970	COG0402	S-adenosylhomocysteine deaminase activity
HC645_RS11025	COG4608	Belongs to the ABC transporter superfamily
HC645_RS11030	COG0444	Belongs to the ABC transporter superfamily
HC645_RS11055	COG0346	lactoylglutathione lyase activity
HC645_RS11060	COG1349	DNA-binding transcription factor activity
HC645_RS11100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HC645_RS11165	COG0307	riboflavin synthase, alpha
HC645_RS11170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC645_RS11175	COG2814	Major facilitator Superfamily
HC645_RS11180	COG0583	DNA-binding transcription factor activity
HC645_RS11195	COG2814	Major facilitator Superfamily
HC645_RS11210	COG0791	NLP P60 protein
HC645_RS11215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HC645_RS11225	COG0346	lactoylglutathione lyase activity
HC645_RS11230	COG1902	pentaerythritol trinitrate reductase activity
HC645_RS11235	COG1309	transcriptional regulator
HC645_RS11240	COG3313	Fe-S protein
HC645_RS11245	COG4989	oxidoreductase activity
HC645_RS11250	COG2032	superoxide dismutase activity
HC645_RS11255	COG1289	transmembrane transporter activity
HC645_RS11260	COG1566	PFAM secretion protein HlyD family protein
HC645_RS11275	COG3706	GGDEF domain
HC645_RS11290	COG3895	Periplasmic Protein
HC645_RS11305	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HC645_RS11310	COG0625	glutathione transferase activity
HC645_RS11320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC645_RS11330	COG4659	FMN binding
HC645_RS11365	COG2723	6-phospho-beta-galactosidase activity
HC645_RS11375	COG0673	inositol 2-dehydrogenase activity
HC645_RS11385	COG2814	Major facilitator Superfamily
HC645_RS11405	COG3038	cytochrome b561
HC645_RS11425	COG0583	DNA-binding transcription factor activity
HC645_RS11430	COG3485	protocatechuate 3,4-dioxygenase
HC645_RS11435	COG3485	protocatechuate 3,4-dioxygenase
HC645_RS11440	COG5383	Protein conserved in bacteria
HC645_RS11445	COG2272	Belongs to the type-B carboxylesterase lipase family
HC645_RS11460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC645_RS11465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC645_RS11470	COG1275	C4-dicarboxylate transporter malic acid transport protein
HC645_RS11475	COG0500	methyltransferase
HC645_RS11490	COG2207	Transcriptional regulator
HC645_RS11490	COG3708	Transcriptional regulator
HC645_RS11495	COG3135	benzoate transporter
HC645_RS11500	COG1396	sequence-specific DNA binding
HC645_RS11510	COG0826	peptidase U32
HC645_RS11530	COG1294	oxidase, subunit
HC645_RS11535	COG1271	oxidase subunit
HC645_RS11540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC645_RS11545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HC645_RS11550	COG3842	ATPase activity
HC645_RS11555	COG1176	ABC-type spermidine putrescine transport system, permease component I
HC645_RS11560	COG1177	transmembrane transport
HC645_RS11565	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS11600	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS11610	COG0747	negative chemotaxis
HC645_RS11620	COG3238	Protein conserved in bacteria
HC645_RS11625	COG1247	-acetyltransferase
HC645_RS11635	COG2130	NADP-dependent
HC645_RS11645	COG3691	Protein conserved in bacteria
HC645_RS11650	COG1228	amidohydrolase
HC645_RS11655	COG4772	TonB-dependent receptor
HC645_RS11680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC645_RS11685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC645_RS11690	COG1473	amidohydrolase
HC645_RS11695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC645_RS11710	COG0765	amino acid transport
HC645_RS11715	COG1126	abc transporter atp-binding protein
HC645_RS11725	COG0625	glutathione transferase activity
HC645_RS11750	COG2211	Major facilitator Superfamily
HC645_RS11765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC645_RS11770	COG3842	ATPase activity
HC645_RS11775	COG1840	ABC-type Fe3 transport system, periplasmic component
HC645_RS11780	COG1178	ABC-type Fe3 transport system permease component
HC645_RS11785	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC645_RS11790	COG2181	nitrate reductase activity
HC645_RS11795	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC645_RS11800	COG1140	nitrate reductase beta subunit
HC645_RS11805	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC645_RS11825	COG1414	Transcriptional regulator
HC645_RS11830	COG4948	Mandelate Racemase Muconate Lactonizing
HC645_RS11835	COG4829	muconolactone delta-isomerase
HC645_RS11840	COG3485	protocatechuate 3,4-dioxygenase
HC645_RS11850	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HC645_RS11875	COG0437	4 iron, 4 sulfur cluster binding
HC645_RS11880	COG2864	formate dehydrogenase
HC645_RS11895	COG2326	polyphosphate kinase activity
HC645_RS11905	COG2814	Major facilitator Superfamily
HC645_RS11915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC645_RS11935	COG0747	negative chemotaxis
HC645_RS11940	COG1064	alcohol dehydrogenase
HC645_RS11955	COG0488	(ABC) transporter
HC645_RS12000	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS12005	COG3729	General stress protein
HC645_RS12015	COG3685	Protein conserved in bacteria
HC645_RS12025	COG0366	Alpha amylase catalytic
HC645_RS12035	COG2323	membrane
HC645_RS12045	COG3111	PFAM Bacterial OB fold (BOF) protein
HC645_RS12055	COG1764	response to oxidative stress
HC645_RS12080	COG3781	membrane
HC645_RS12085	COG0243	molybdopterin cofactor binding
HC645_RS12090	COG0583	DNA-binding transcription factor activity
HC645_RS12095	COG2814	Major facilitator Superfamily
HC645_RS12100	COG1285	pathogenesis
HC645_RS12105	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HC645_RS12115	COG0583	DNA-binding transcription factor activity
HC645_RS12135	COG0519	Catalyzes the synthesis of GMP from XMP
HC645_RS12135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC645_RS12175	COG0596	Alpha beta hydrolase
HC645_RS12180	COG0745	RESPONSE REGULATOR receiver
HC645_RS12185	COG2205	protein histidine kinase activity
HC645_RS12200	COG0076	glutamate decarboxylase activity
HC645_RS12205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC645_RS12210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC645_RS12215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC645_RS12220	COG1116	anion transmembrane transporter activity
HC645_RS12225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC645_RS12235	COG0673	inositol 2-dehydrogenase activity
HC645_RS12245	COG1609	Transcriptional regulator
HC645_RS12250	COG3706	GGDEF domain
HC645_RS12255	COG0402	S-adenosylhomocysteine deaminase activity
HC645_RS12260	COG1953	Uracil, thiamine, allantoin
HC645_RS12300	COG0406	alpha-ribazole phosphatase activity
HC645_RS12325	COG2207	Transcriptional regulator
HC645_RS12350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC645_RS12430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC645_RS12440	COG2070	2-Nitropropane dioxygenase
HC645_RS12445	COG0583	DNA-binding transcription factor activity
HC645_RS12455	COG1902	pentaerythritol trinitrate reductase activity
HC645_RS12460	COG4529	Protein conserved in bacteria
HC645_RS12465	COG0477	Major facilitator Superfamily
HC645_RS12510	COG2223	nitrite transmembrane transporter activity
HC645_RS12520	COG1609	Transcriptional regulator
HC645_RS12525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS12535	COG3037	sugar-specific permease SgaT UlaA
HC645_RS12540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC645_RS12550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC645_RS12555	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HC645_RS12555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC645_RS12555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC645_RS12570	COG0583	DNA-binding transcription factor activity
HC645_RS12575	COG0583	DNA-binding transcription factor activity
HC645_RS12580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC645_RS12590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC645_RS12605	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS12615	COG1609	Transcriptional regulator
HC645_RS12645	COG1652	LysM domain
HC645_RS12670	COG0456	acetyltransferase
HC645_RS12670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC645_RS12680	COG0667	Aldo Keto reductase
HC645_RS12685	COG0667	Aldo Keto reductase
HC645_RS12690	COG3386	PFAM SMP-30 Gluconolaconase
HC645_RS12695	COG0667	Aldo Keto reductase
HC645_RS12740	COG4128	Pfam Zonular occludens toxin
HC645_RS12750	COG4584	PFAM Integrase catalytic
HC645_RS12755	COG1484	DNA-dependent DNA replication
HC645_RS12780	COG4977	sequence-specific DNA binding
HC645_RS12800	COG4977	sequence-specific DNA binding
HC645_RS12805	COG1349	DNA-binding transcription factor activity
HC645_RS12820	COG1349	DNA-binding transcription factor activity
HC645_RS12825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC645_RS12830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS12835	COG0738	Major facilitator superfamily
HC645_RS12880	COG1929	Belongs to the glycerate kinase type-1 family
HC645_RS12885	COG3835	regulator
HC645_RS12905	COG2186	Transcriptional regulator
HC645_RS12910	COG1263	PTS System
HC645_RS12910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS12925	COG2814	Major facilitator Superfamily
HC645_RS12930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS12930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS12950	COG2819	hydrolase of the alpha beta superfamily
HC645_RS12955	COG3300	MHYT domain
HC645_RS12955	COG5001	Diguanylate cyclase
HC645_RS12990	COG3188	usher protein
HC645_RS13005	COG3550	peptidyl-serine autophosphorylation
HC645_RS13010	COG1396	sequence-specific DNA binding
HC645_RS13015	COG2351	hydroxyisourate hydrolase activity
HC645_RS13020	COG3648	Uricase
HC645_RS13020	COG3195	allantoin biosynthetic process
HC645_RS13025	COG2233	PERMEase
HC645_RS13055	COG2207	Transcriptional regulator
HC645_RS13070	COG4628	conserved protein (DUF2132)
HC645_RS13090	COG2011	ABC-type metal ion transport system permease component
HC645_RS13095	COG2070	2-Nitropropane dioxygenase
HC645_RS13110	COG0477	Major facilitator Superfamily
HC645_RS13160	COG2199	diguanylate cyclase activity
HC645_RS13175	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS13180	COG0583	DNA-binding transcription factor activity
HC645_RS13190	COG0039	L-malate dehydrogenase activity
HC645_RS13195	COG1349	DNA-binding transcription factor activity
HC645_RS13200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HC645_RS13205	COG3395	kinase activity
HC645_RS13215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC645_RS13220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC645_RS13225	COG2271	Major facilitator Superfamily
HC645_RS13255	COG4977	sequence-specific DNA binding
HC645_RS13265	COG0697	spore germination
HC645_RS13270	COG2814	Major facilitator Superfamily
HC645_RS13300	COG0683	leucine binding
HC645_RS13305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC645_RS13345	COG2223	nitrite transmembrane transporter activity
HC645_RS13350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC645_RS13365	COG1349	DNA-binding transcription factor activity
HC645_RS13370	COG2084	Dehydrogenase
HC645_RS13380	COG0235	Class ii aldolase
HC645_RS13385	COG3622	Belongs to the hyi family
HC645_RS13390	COG2610	gluconate transmembrane transporter activity
HC645_RS13395	COG2207	Transcriptional regulator
HC645_RS13395	COG3708	Transcriptional regulator
HC645_RS13410	COG2200	EAL domain
HC645_RS13415	COG1546	Belongs to the CinA family
HC645_RS13420	COG0071	Belongs to the small heat shock protein (HSP20) family
HC645_RS13455	COG2135	peptidase activity
HC645_RS13460	COG2207	Transcriptional regulator
HC645_RS13475	COG4221	oxidoreductase activity
HC645_RS13480	COG1802	Transcriptional regulator
HC645_RS13485	COG0589	response to stress
HC645_RS13490	COG0246	Mannitol dehydrogenase
HC645_RS13495	COG2271	Major facilitator Superfamily
HC645_RS13510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC645_RS13525	COG0243	molybdopterin cofactor binding
HC645_RS13530	COG0437	4 iron, 4 sulfur cluster binding
HC645_RS13535	COG3302	dmso reductase anchor subunit
HC645_RS13550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HC645_RS13555	COG1940	carbohydrate kinase activity
HC645_RS13560	COG0583	DNA-binding transcription factor activity
HC645_RS13565	COG2814	Major facilitator Superfamily
HC645_RS13570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC645_RS13590	COG3591	Belongs to the peptidase S1B family
HC645_RS13610	COG0628	permease
HC645_RS13640	COG0679	Auxin Efflux Carrier
HC645_RS13650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC645_RS13675	COG3290	protein histidine kinase activity
HC645_RS13680	COG4565	transcriptional regulatory protein
HC645_RS13700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HC645_RS13700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HC645_RS13710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC645_RS13715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HC645_RS13725	COG0183	Belongs to the thiolase family
HC645_RS13730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC645_RS13740	COG1414	Transcriptional regulator
HC645_RS13745	COG2840	Smr protein MutS2
HC645_RS13750	COG0583	DNA-binding transcription factor activity
HC645_RS13760	COG1473	amidohydrolase
HC645_RS13765	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HC645_RS13780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC645_RS13795	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HC645_RS13800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HC645_RS13820	COG0531	amino acid
HC645_RS13830	COG3136	membrane protein required for alginate biosynthesis
HC645_RS13835	COG0745	RESPONSE REGULATOR receiver
HC645_RS13845	COG2205	protein histidine kinase activity
HC645_RS13855	COG0114	fumarate hydratase activity
HC645_RS13860	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HC645_RS13860	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HC645_RS13865	COG1482	cell wall glycoprotein biosynthetic process
HC645_RS13870	COG5339	Protein conserved in bacteria
HC645_RS13875	COG1609	Transcriptional regulator
HC645_RS13880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS13880	COG1263	PTS System
HC645_RS13885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC645_RS13910	COG2391	methyltransferase activity
HC645_RS13915	COG0425	Belongs to the sulfur carrier protein TusA family
HC645_RS13920	COG5562	phage envelope protein
HC645_RS13925	COG0401	homolog of Blt101
HC645_RS13930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC645_RS13935	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS13945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HC645_RS13955	COG1113	amino acid transport
HC645_RS13960	COG2988	succinylglutamate desuccinylase activity
HC645_RS13965	COG3724	N-succinylarginine dihydrolase activity
HC645_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS13975	COG3138	arginine N-succinyltransferase
HC645_RS13990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC645_RS13995	COG0667	Aldo Keto reductase
HC645_RS14000	COG0583	DNA-binding transcription factor activity
HC645_RS14025	COG4122	O-methyltransferase activity
HC645_RS14030	COG1643	Atp-dependent helicase
HC645_RS14045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC645_RS14050	COG3327	negative regulation of DNA-templated transcription, initiation
HC645_RS14055	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HC645_RS14060	COG0183	Belongs to the thiolase family
HC645_RS14065	COG2050	protein possibly involved in aromatic compounds catabolism
HC645_RS14070	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC645_RS14075	COG1024	Enoyl-CoA hydratase
HC645_RS14080	COG1024	Enoyl-CoA hydratase
HC645_RS14085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC645_RS14090	COG2151	metal-sulfur cluster biosynthetic enzyme
HC645_RS14095	COG3396	Phenylacetate-CoA oxygenase
HC645_RS14100	COG3460	Phenylacetate-CoA oxygenase
HC645_RS14105	COG3396	Phenylacetate-CoA oxygenase
HC645_RS14110	COG2030	dehydratase
HC645_RS14110	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS14145	COG2072	flavoprotein involved in K transport
HC645_RS14150	COG0583	DNA-binding transcription factor activity
HC645_RS14155	COG1126	abc transporter atp-binding protein
HC645_RS14165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS14180	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS14185	COG2207	Transcriptional regulator
HC645_RS14190	COG3784	Protein of unknown function (DUF1318)
HC645_RS14200	COG2911	Protein conserved in bacteria
HC645_RS14205	COG0586	Pfam SNARE associated Golgi protein
HC645_RS14210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC645_RS14215	COG3187	Heat shock protein
HC645_RS14220	COG3042	response to heat
HC645_RS14225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC645_RS14225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HC645_RS14225	COG1013	pyruvate-flavodoxin oxidoreductase activity
HC645_RS14225	COG0674	pyruvate-flavodoxin oxidoreductase activity
HC645_RS14230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HC645_RS14240	COG0589	response to stress
HC645_RS14250	COG0513	Belongs to the DEAD box helicase family
HC645_RS14260	COG1349	DNA-binding transcription factor activity
HC645_RS14265	COG0673	inositol 2-dehydrogenase activity
HC645_RS14280	COG2011	ABC-type metal ion transport system permease component
HC645_RS14295	COG0436	Aminotransferase
HC645_RS14300	COG0604	alcohol dehydrogenase
HC645_RS14330	COG0583	DNA-binding transcription factor activity
HC645_RS14350	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS14355	COG1309	transcriptional regulator
HC645_RS14360	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS14430	COG2885	chlorophyll binding
HC645_RS14460	COG0693	protein deglycase activity
HC645_RS14465	COG1078	dGTPase activity
HC645_RS14470	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS14475	COG0583	DNA-binding transcription factor activity
HC645_RS14495	COG0656	L-ascorbic acid biosynthetic process
HC645_RS14520	COG4166	transmembrane transport
HC645_RS14530	COG2866	Carboxypeptidase
HC645_RS14535	COG4948	Mandelate Racemase Muconate Lactonizing
HC645_RS14540	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC645_RS14545	COG3180	Ammonia monooxygenase
HC645_RS14555	COG1486	melibiose metabolic process
HC645_RS14560	COG0583	DNA-binding transcription factor activity
HC645_RS14570	COG3106	COG3106 Predicted ATPase
HC645_RS14580	COG1983	PspC domain protein
HC645_RS14590	COG1842	Phage shock protein A
HC645_RS14595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC645_RS14605	COG1473	amidohydrolase
HC645_RS14620	COG0702	epimerase
HC645_RS14635	COG4171	peptide transport system, permease
HC645_RS14650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC645_RS14660	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC645_RS14665	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC645_RS14665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC645_RS14680	COG1349	DNA-binding transcription factor activity
HC645_RS14695	COG0023	Translation Initiation Factor
HC645_RS14705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HC645_RS14710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HC645_RS14715	COG0671	phosphoesterase, PA-phosphatase related
HC645_RS14725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC645_RS14750	COG0616	signal peptide processing
HC645_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS14765	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HC645_RS14775	COG0583	DNA-binding transcription factor activity
HC645_RS14785	COG0009	L-threonylcarbamoyladenylate synthase
HC645_RS14795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC645_RS14800	COG0512	Glutamine amidotransferase of anthranilate synthase
HC645_RS14800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC645_RS14805	COG0135	phosphoribosylanthranilate isomerase activity
HC645_RS14805	COG0134	indole-3-glycerol-phosphate synthase activity
HC645_RS14840	COG4774	siderophore transport
HC645_RS14850	COG3047	cAMP biosynthetic process
HC645_RS14855	COG0727	PFAM Uncharacterised protein family (UPF0153)
HC645_RS14885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC645_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS14895	COG1988	membrane-bound metal-dependent
HC645_RS14910	COG0753	catalase activity
HC645_RS14920	COG1486	melibiose metabolic process
HC645_RS14925	COG2169	Transcriptional regulator
HC645_RS14925	COG1917	Cupin 2, conserved barrel domain protein
HC645_RS14930	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC645_RS14935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS14945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS14950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC645_RS14960	COG0322	excinuclease ABC activity
HC645_RS14965	COG3678	ATP-independent chaperone mediated protein folding
HC645_RS14975	COG3724	N-succinylarginine dihydrolase activity
HC645_RS14985	COG3138	arginine N-succinyltransferase
HC645_RS14995	COG0708	Exodeoxyribonuclease III
HC645_RS15000	COG0398	Pfam SNARE associated Golgi protein
HC645_RS15005	COG0398	Pfam SNARE associated Golgi protein
HC645_RS15010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC645_RS15015	COG4134	Bacterial extracellular solute-binding protein
HC645_RS15020	COG4135	transport system, permease component
HC645_RS15025	COG4136	ATPase activity
HC645_RS15030	COG2897	thiosulfate sulfurtransferase activity
HC645_RS15035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC645_RS15040	COG0494	nUDIX hydrolase
HC645_RS15045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC645_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS15050	COG3321	synthase
HC645_RS15050	COG0604	alcohol dehydrogenase
HC645_RS15055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC645_RS15060	COG0709	Synthesizes selenophosphate from selenide and ATP
HC645_RS15070	COG0778	Nitroreductase
HC645_RS15075	COG0616	signal peptide processing
HC645_RS15080	COG0252	asparaginase activity
HC645_RS15085	COG1335	isochorismatase
HC645_RS15090	COG2814	Major facilitator Superfamily
HC645_RS15095	COG1349	DNA-binding transcription factor activity
HC645_RS15100	COG0667	Aldo Keto reductase
HC645_RS15105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS15110	COG0191	fructose-bisphosphate aldolase activity
HC645_RS15115	COG1063	alcohol dehydrogenase
HC645_RS15120	COG2271	Major facilitator Superfamily
HC645_RS15125	COG1063	alcohol dehydrogenase
HC645_RS15140	COG3139	Protein of unknown function (DUF1315)
HC645_RS15160	COG0656	L-ascorbic acid biosynthetic process
HC645_RS15165	COG3713	MltA-interacting MipA family protein
HC645_RS15170	COG2766	serine protein kinase
HC645_RS15185	COG0386	Belongs to the glutathione peroxidase family
HC645_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS15215	COG0583	DNA-binding transcription factor activity
HC645_RS15220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC645_RS15225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC645_RS15235	COG0859	PFAM glycosyl transferase family 9
HC645_RS15240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC645_RS15250	COG2207	Transcriptional regulator
HC645_RS15255	COG2807	transmembrane transport
HC645_RS15260	COG0504	CTP synthase activity
HC645_RS15265	COG1683	Conserved Protein
HC645_RS15270	COG3189	MarR family transcriptional regulator
HC645_RS15275	COG3042	response to heat
HC645_RS15280	COG2203	Gaf domain
HC645_RS15280	COG2199	diguanylate cyclase activity
HC645_RS15300	COG3182	Iron-regulated membrane protein
HC645_RS15310	COG1560	Kdo2-lipid A biosynthetic process
HC645_RS15325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HC645_RS15330	COG3706	GGDEF domain
HC645_RS15335	COG0583	DNA-binding transcription factor activity
HC645_RS15340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC645_RS15370	COG1294	oxidase, subunit
HC645_RS15375	COG1271	oxidase subunit
HC645_RS15380	COG3546	catalase activity
HC645_RS15385	COG3685	Protein conserved in bacteria
HC645_RS15390	COG3685	Protein conserved in bacteria
HC645_RS15395	COG3729	General stress protein
HC645_RS15405	COG1063	alcohol dehydrogenase
HC645_RS15410	COG3813	Protein conserved in bacteria
HC645_RS15435	COG0640	Transcriptional regulator
HC645_RS15440	COG0538	isocitrate dehydrogenase activity
HC645_RS15445	COG1187	pseudouridine synthase activity
HC645_RS15465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC645_RS15485	COG2205	protein histidine kinase activity
HC645_RS15490	COG2850	peptidyl-arginine hydroxylation
HC645_RS15510	COG1177	transmembrane transport
HC645_RS15525	COG0318	PFAM AMP-dependent synthetase and ligase
HC645_RS15530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC645_RS15535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC645_RS15540	COG0698	ribose 5-phosphate isomerase
HC645_RS15555	COG3395	kinase activity
HC645_RS15570	COG2390	Transcriptional regulator
HC645_RS15580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC645_RS15590	COG4591	ABC-type transport system involved in lipoprotein release permease component
HC645_RS15600	COG4591	ABC-type transport system involved in lipoprotein release permease component
HC645_RS15610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC645_RS15615	COG1388	LysM domain
HC645_RS15615	COG1376	ErfK ybiS ycfS ynhG family protein
HC645_RS15630	COG1309	transcriptional regulator
HC645_RS15645	COG3134	Outer membrane lipoprotein
HC645_RS15650	COG1252	NADH dehydrogenase
HC645_RS15675	COG5633	Lipoprotein
HC645_RS15680	COG0537	adenosine 5'-monophosphoramidase activity
HC645_RS15690	COG0084	hydrolase, TatD family'
HC645_RS15695	COG0470	DNA polymerase III
HC645_RS15705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC645_RS15710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC645_RS15715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC645_RS15730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC645_RS15750	COG1399	metal-binding, possibly nucleic acid-binding protein
HC645_RS15770	COG1530	ribonuclease E activity
HC645_RS15775	COG0583	DNA-binding transcription factor activity
HC645_RS15780	COG2814	Major facilitator Superfamily
HC645_RS15800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC645_RS15850	COG1560	Kdo2-lipid A biosynthetic process
HC645_RS15865	COG5645	(Lipo)protein
HC645_RS15900	COG3381	protein complex oligomerization
HC645_RS15925	COG0583	DNA-binding transcription factor activity
HC645_RS15935	COG1335	isochorismatase
HC645_RS15950	COG1702	phosphate starvation-inducible protein PhoH
HC645_RS15970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC645_RS15985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC645_RS16000	COG1309	transcriptional regulator
HC645_RS16035	COG2233	PERMEase
HC645_RS16045	COG3729	General stress protein
HC645_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS16090	COG0531	amino acid
HC645_RS16095	COG0174	glutamine synthetase
HC645_RS16100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HC645_RS16105	COG1396	sequence-specific DNA binding
HC645_RS16105	COG1917	Cupin 2, conserved barrel domain protein
HC645_RS16110	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS16115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC645_RS16120	COG0583	DNA-binding transcription factor activity
HC645_RS16125	COG0473	3-isopropylmalate dehydrogenase activity
HC645_RS16130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC645_RS16135	COG4638	Rieske (2fe-2S)
HC645_RS16140	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS16145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC645_RS16170	COG0670	Belongs to the BI1 family
HC645_RS16185	COG2207	Transcriptional regulator
HC645_RS16190	COG1881	PFAM PEBP family protein
HC645_RS16205	COG1832	CoA-binding protein
HC645_RS16215	COG0210	DNA helicase
HC645_RS16220	COG3304	Inner membrane component domain
HC645_RS16225	COG1289	transmembrane transporter activity
HC645_RS16230	COG3070	regulator of competence-specific genes
HC645_RS16250	COG1067	ATP-dependent peptidase activity
HC645_RS16260	COG3130	regulation of translation
HC645_RS16265	COG3009	Protein conserved in bacteria
HC645_RS16270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HC645_RS16270	COG3008	intermembrane lipid transfer
HC645_RS16275	COG2995	paraquat-inducible protein a
HC645_RS16280	COG0488	(ABC) transporter
HC645_RS16290	COG0633	Ferredoxin
HC645_RS16290	COG3217	Mosc domain protein beta barrel domain protein
HC645_RS16305	COG0431	NADPH-dependent FMN reductase
HC645_RS16310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC645_RS16315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC645_RS16320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC645_RS16330	COG0308	aminopeptidase N
HC645_RS16340	COG1473	amidohydrolase
HC645_RS16350	COG0814	amino acid
HC645_RS16370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HC645_RS16375	COG1448	Aminotransferase
HC645_RS16380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC645_RS16385	COG3108	Peptidase M15
HC645_RS16390	COG2989	Protein conserved in bacteria
HC645_RS16400	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HC645_RS16410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC645_RS16415	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HC645_RS16420	COG3173	Aminoglycoside phosphotransferase
HC645_RS16435	COG3214	Protein conserved in bacteria
HC645_RS16450	COG0658	competence protein
HC645_RS16450	COG2333	competence protein COMEC
HC645_RS16460	COG0539	negative regulation of cytoplasmic translation
HC645_RS16480	COG2323	membrane
HC645_RS16485	COG1944	ATP diphosphatase activity
HC645_RS16490	COG2116	formate transmembrane transporter activity
HC645_RS16495	COG1882	Formate acetyltransferase
HC645_RS16500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HC645_RS16505	COG0477	Major facilitator Superfamily
HC645_RS16515	COG3302	dmso reductase anchor subunit
HC645_RS16520	COG0437	4 iron, 4 sulfur cluster binding
HC645_RS16525	COG0243	molybdopterin cofactor binding
HC645_RS16535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC645_RS16545	COG1178	ABC-type Fe3 transport system permease component
HC645_RS16545	COG1674	ftsk spoiiie
HC645_RS16560	COG0492	ferredoxin-NADP+ reductase activity
HC645_RS16565	COG4988	ABC transporter
HC645_RS16570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC645_RS16585	COG0542	response to heat
HC645_RS16595	COG1278	Cold shock
HC645_RS16605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS16610	COG3593	DNA synthesis involved in DNA repair
HC645_RS16620	COG2431	L-lysine efflux transmembrane transporter activity
HC645_RS16630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC645_RS16640	COG0028	Belongs to the TPP enzyme family
HC645_RS16645	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HC645_RS16650	COG0702	epimerase
HC645_RS16655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC645_RS16660	COG3023	N-Acetylmuramoyl-L-alanine amidase
HC645_RS16665	COG5001	Diguanylate cyclase
HC645_RS16665	COG3706	GGDEF domain
HC645_RS16665	COG4251	negative regulation of phosphorylation
HC645_RS16665	COG2203	Gaf domain
HC645_RS16675	COG1126	abc transporter atp-binding protein
HC645_RS16680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS16685	COG4215	(ABC) transporter
HC645_RS16690	COG4160	amino acid transport
HC645_RS16695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS16700	COG5002	protein histidine kinase activity
HC645_RS16705	COG0745	RESPONSE REGULATOR receiver
HC645_RS16710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC645_RS16720	COG1177	transmembrane transport
HC645_RS16725	COG1176	ABC-type spermidine putrescine transport system, permease component I
HC645_RS16730	COG3842	ATPase activity
HC645_RS16735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HC645_RS16750	COG0778	Nitroreductase
HC645_RS16780	COG3226	Transcriptional regulator
HC645_RS16785	COG0738	Major facilitator superfamily
HC645_RS16790	COG0561	phosphatase activity
HC645_RS16795	COG2814	Major facilitator Superfamily
HC645_RS16800	COG0671	phosphoesterase, PA-phosphatase related
HC645_RS16805	COG1349	DNA-binding transcription factor activity
HC645_RS16810	COG1686	Belongs to the peptidase S11 family
HC645_RS16820	COG0625	glutathione transferase activity
HC645_RS16825	COG2133	pyrroloquinoline quinone binding
HC645_RS16835	COG2223	nitrite transmembrane transporter activity
HC645_RS16855	COG0747	negative chemotaxis
HC645_RS16870	COG0303	'Molybdopterin
HC645_RS16875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC645_RS16880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HC645_RS16885	COG1882	Formate acetyltransferase
HC645_RS16890	COG0561	phosphatase activity
HC645_RS16900	COG1609	Transcriptional regulator
HC645_RS16905	COG2271	Major facilitator Superfamily
HC645_RS16915	COG0488	(ABC) transporter
HC645_RS16920	COG2365	Tyrosine phosphatase family
HC645_RS16925	COG1376	ErfK ybiS ycfS ynhG family protein
HC645_RS16930	COG2188	Transcriptional regulator
HC645_RS16935	COG2723	6-phospho-beta-galactosidase activity
HC645_RS16940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC645_RS16955	COG2194	sulfuric ester hydrolase activity
HC645_RS16960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HC645_RS16980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS16985	COG0765	amino acid transport
HC645_RS16990	COG1126	abc transporter atp-binding protein
HC645_RS16995	COG0668	transmembrane transport
HC645_RS17005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC645_RS17015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC645_RS17025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC645_RS17030	COG1199	ATP-dependent helicase activity
HC645_RS17035	COG0513	Belongs to the DEAD box helicase family
HC645_RS17040	COG3958	Transketolase
HC645_RS17045	COG3959	Transketolase, thiamine diphosphate binding domain
HC645_RS17050	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS17055	COG2271	Major facilitator Superfamily
HC645_RS17065	COG0583	DNA-binding transcription factor activity
HC645_RS17070	COG1309	transcriptional regulator
HC645_RS17075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS17080	COG1131	(ABC) transporter
HC645_RS17085	COG0842	Transport permease protein
HC645_RS17090	COG0842	Transport permease protein
HC645_RS17100	COG3568	Endonuclease Exonuclease Phosphatase
HC645_RS17105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC645_RS17110	COG0392	lysyltransferase activity
HC645_RS17115	COG0670	Belongs to the BI1 family
HC645_RS17120	COG0314	molybdopterin synthase activity
HC645_RS17125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC645_RS17135	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC645_RS17155	COG0745	RESPONSE REGULATOR receiver
HC645_RS17160	COG0642	Histidine kinase
HC645_RS17185	COG2226	methyltransferase
HC645_RS17200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC645_RS17205	COG1881	PFAM PEBP family protein
HC645_RS17245	COG4677	pectinesterase activity
HC645_RS17255	COG0589	response to stress
HC645_RS17260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS17295	COG0789	Transcriptional regulator
HC645_RS17300	COG2200	EAL domain
HC645_RS17325	COG0561	phosphatase activity
HC645_RS17335	COG4149	molybdate abc transporter
HC645_RS17340	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC645_RS17350	COG3585	molybdate ion transport
HC645_RS17350	COG2005	Transcriptional regulator
HC645_RS17360	COG1119	ATPase activity
HC645_RS17370	COG1085	galactose-1-phosphate uridylyltransferase
HC645_RS17380	COG2017	converts alpha-aldose to the beta-anomer
HC645_RS17390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC645_RS17405	COG3201	nicotinamide mononucleotide transporter
HC645_RS17410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC645_RS17465	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HC645_RS17470	COG2885	chlorophyll binding
HC645_RS17480	COG3064	Membrane
HC645_RS17485	COG0848	biopolymer transport protein
HC645_RS17490	COG0811	peptide transport
HC645_RS17495	COG0824	Thioesterase
HC645_RS17500	COG3790	cyd operon protein YbgE
HC645_RS17505	COG4890	Cyd operon protein YbgT
HC645_RS17510	COG1294	oxidase, subunit
HC645_RS17515	COG1271	oxidase subunit
HC645_RS17525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC645_RS17535	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC645_RS17540	COG0567	Dehydrogenase, E1 component
HC645_RS17545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC645_RS17550	COG1053	succinate dehydrogenase
HC645_RS17555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HC645_RS17560	COG2009	succinate dehydrogenase
HC645_RS17595	COG1984	allophanate hydrolase subunit 2
HC645_RS17600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC645_RS17615	COG0415	Belongs to the DNA photolyase family
HC645_RS17645	COG2205	protein histidine kinase activity
HC645_RS17650	COG0745	RESPONSE REGULATOR receiver
HC645_RS17660	COG0033	Phosphoglucomutase
HC645_RS17670	COG0596	Alpha beta hydrolase
HC645_RS17685	COG0735	belongs to the Fur family
HC645_RS17725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC645_RS17730	COG1940	carbohydrate kinase activity
HC645_RS17730	COG1846	Transcriptional regulator
HC645_RS17735	COG0647	UMP catabolic process
HC645_RS17740	COG0367	asparagine synthase
HC645_RS17780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC645_RS17790	COG1702	phosphate starvation-inducible protein PhoH
HC645_RS17815	COG0765	amino acid transport
HC645_RS17820	COG0765	amino acid transport
HC645_RS17825	COG1126	abc transporter atp-binding protein
HC645_RS17840	COG2888	peptidyl-tyrosine sulfation
HC645_RS17855	COG1466	dna polymerase III delta subunit
HC645_RS17870	COG0799	negative regulation of ribosome biogenesis
HC645_RS17880	COG0768	penicillin binding
HC645_RS17885	COG0772	Belongs to the SEDS family
HC645_RS17890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC645_RS17895	COG1686	Belongs to the peptidase S11 family
HC645_RS17910	COG0583	DNA-binding transcription factor activity
HC645_RS17925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC645_RS17945	COG3069	C4-dicarboxylate transmembrane transporter activity
HC645_RS17950	COG3719	Belongs to the RNase T2 family
HC645_RS17955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC645_RS17975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC645_RS17980	COG0583	DNA-binding transcription factor activity
HC645_RS17985	COG3969	phosphoadenosine phosphosulfate
HC645_RS17990	COG1475	DNA binding
HC645_RS17995	COG0436	Aminotransferase
HC645_RS18020	COG1129	ABC transporter
HC645_RS18025	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS18030	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS18040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC645_RS18055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC645_RS18065	COG0402	S-adenosylhomocysteine deaminase activity
HC645_RS18075	COG0483	inositol monophosphate 1-phosphatase activity
HC645_RS18080	COG2271	Major facilitator Superfamily
HC645_RS18115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS18120	COG1129	ABC transporter
HC645_RS18125	COG0371	Dehydrogenase
HC645_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS18155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HC645_RS18165	COG2188	Transcriptional regulator
HC645_RS18175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS18190	COG2211	Major facilitator Superfamily
HC645_RS18195	COG2879	small protein
HC645_RS18200	COG1966	Carbon starvation protein
HC645_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS18215	COG3433	isochorismatase activity
HC645_RS18215	COG1535	isochorismatase
HC645_RS18220	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC645_RS18225	COG1169	isochorismate synthase
HC645_RS18230	COG4592	Periplasmic binding protein
HC645_RS18240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS18245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS18250	COG1120	ATPase activity
HC645_RS18255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC645_RS18255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC645_RS18260	COG3251	PFAM MbtH domain protein
HC645_RS18265	COG2382	esterase
HC645_RS18270	COG4771	TonB-dependent receptor
HC645_RS18275	COG2977	Belongs to the P-Pant transferase superfamily
HC645_RS18280	COG3958	Transketolase
HC645_RS18285	COG3959	Transketolase, thiamine diphosphate binding domain
HC645_RS18290	COG2390	Transcriptional regulator
HC645_RS18295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC645_RS18300	COG1879	ABC-type sugar transport system periplasmic component
HC645_RS18310	COG1129	ABC transporter
HC645_RS18315	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS18325	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS18335	COG0583	DNA-binding transcription factor activity
HC645_RS18340	COG0668	transmembrane transport
HC645_RS18350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC645_RS18375	COG0747	negative chemotaxis
HC645_RS18380	COG0601	transmembrane transport
HC645_RS18385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC645_RS18390	COG0444	Belongs to the ABC transporter superfamily
HC645_RS18395	COG4608	Belongs to the ABC transporter superfamily
HC645_RS18405	COG4221	oxidoreductase activity
HC645_RS18415	COG4215	(ABC) transporter
HC645_RS18420	COG0765	amino acid transport
HC645_RS18425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HC645_RS18440	COG0697	spore germination
HC645_RS18455	COG4608	Belongs to the ABC transporter superfamily
HC645_RS18460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC645_RS18470	COG4166	transmembrane transport
HC645_RS18480	COG3698	Phosphodiester glycosidase
HC645_RS18525	COG2315	Protein conserved in bacteria
HC645_RS18530	COG0778	Nitroreductase
HC645_RS18540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS18550	COG3716	PTS system mannose fructose sorbose family IID component
HC645_RS18555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC645_RS18560	COG2222	sugar isomerase
HC645_RS18565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC645_RS18565	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC645_RS18580	COG0477	Major facilitator Superfamily
HC645_RS18585	COG0668	transmembrane transport
HC645_RS18600	COG0673	inositol 2-dehydrogenase activity
HC645_RS18610	COG2211	Major facilitator Superfamily
HC645_RS18615	COG1113	amino acid transport
HC645_RS18630	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS18635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC645_RS18645	COG0531	amino acid
HC645_RS18690	COG0667	Aldo Keto reductase
HC645_RS18695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS18700	COG1473	amidohydrolase
HC645_RS18735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS18740	COG1120	ATPase activity
HC645_RS18745	COG1566	PFAM secretion protein HlyD family protein
HC645_RS18800	COG4211	Belongs to the binding-protein-dependent transport system permease family
HC645_RS18805	COG1129	ABC transporter
HC645_RS18820	COG0673	inositol 2-dehydrogenase activity
HC645_RS18850	COG3104	oligopeptide transport
HC645_RS18855	COG1982	Orn Lys Arg decarboxylase major
HC645_RS18860	COG0531	amino acid
HC645_RS18865	COG3710	Transcriptional regulator
HC645_RS18875	COG1560	Kdo2-lipid A biosynthetic process
HC645_RS18890	COG3188	usher protein
HC645_RS18895	COG3121	Chaperone
HC645_RS18900	COG3539	Fimbrial protein
HC645_RS18950	COG2501	S4 domain
HC645_RS18960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC645_RS18975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC645_RS18980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC645_RS19000	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HC645_RS19005	COG4181	ATPase activity
HC645_RS19010	COG2755	lipolytic protein G-D-S-L family
HC645_RS19015	COG0300	oxidoreductase activity
HC645_RS19020	COG3118	belongs to the thioredoxin family
HC645_RS19025	COG0390	transport system, permease component
HC645_RS19030	COG4619	ABC transporter
HC645_RS19035	COG0330	HflC and HflK could
HC645_RS19040	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC645_RS19055	COG3735	TraB family
HC645_RS19060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC645_RS19070	COG2223	nitrite transmembrane transporter activity
HC645_RS19085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC645_RS19085	COG4651	solute:proton antiporter activity
HC645_RS19090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS19130	COG2832	Protein of unknown function (DUF454)
HC645_RS19135	COG3923	Primosomal replication protein n
HC645_RS19145	COG5464	transposase or invertase
HC645_RS19150	COG3264	Mechanosensitive ion channel
HC645_RS19150	COG1196	nuclear chromosome segregation
HC645_RS19155	COG1309	transcriptional regulator
HC645_RS19160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS19165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC645_RS19180	COG0110	maltose O-acetyltransferase activity
HC645_RS19230	COG1874	Beta-galactosidase
HC645_RS19235	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC645_RS19240	COG3833	ABC-type maltose transport systems, permease component
HC645_RS19245	COG1175	transmembrane transport
HC645_RS19250	COG2182	Extracellular solute-binding protein
HC645_RS19265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HC645_RS19280	COG2364	Membrane
HC645_RS19310	COG3695	enzyme binding
HC645_RS19315	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HC645_RS19320	COG1946	Acyl-CoA thioesterase
HC645_RS19325	COG0004	ammonium transporteR
HC645_RS19330	COG0347	Belongs to the P(II) protein family
HC645_RS19335	COG1132	(ABC) transporter
HC645_RS19340	COG1132	(ABC) transporter
HC645_RS19345	COG1522	sequence-specific DNA binding
HC645_RS19360	COG4533	DNA binding
HC645_RS19370	COG0824	Thioesterase
HC645_RS19375	COG1555	photosystem II stabilization
HC645_RS19380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC645_RS19385	COG0776	regulation of translation
HC645_RS19390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC645_RS19415	COG0271	Belongs to the BolA IbaG family
HC645_RS19420	COG3056	Lipoprotein
HC645_RS19425	COG2223	nitrite transmembrane transporter activity
HC645_RS19430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC645_RS19435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC645_RS19440	COG1845	cytochrome c oxidase, subunit III
HC645_RS19445	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC645_RS19460	COG1414	Transcriptional regulator
HC645_RS19465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC645_RS19470	COG1053	succinate dehydrogenase
HC645_RS19480	COG1053	succinate dehydrogenase
HC645_RS19495	COG0673	inositol 2-dehydrogenase activity
HC645_RS19500	COG2814	Major facilitator Superfamily
HC645_RS19510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC645_RS19515	COG0693	protein deglycase activity
HC645_RS19535	COG0142	geranyltranstransferase activity
HC645_RS19545	COG0667	Aldo Keto reductase
HC645_RS19550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC645_RS19570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC645_RS19570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC645_RS19580	COG4238	major outer membrane lipoprotein
HC645_RS19600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC645_RS19605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC645_RS19610	COG1862	Preprotein translocase
HC645_RS19635	COG0450	alkyl hydroperoxide reductase
HC645_RS19645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS19660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS19670	COG1228	amidohydrolase
HC645_RS19680	COG1335	isochorismatase
HC645_RS19685	COG0583	DNA-binding transcription factor activity
HC645_RS19690	COG0366	Alpha amylase catalytic
HC645_RS19715	COG0420	3'-5' exonuclease activity
HC645_RS19720	COG0419	ATPase involved in DNA repair
HC645_RS19725	COG1940	carbohydrate kinase activity
HC645_RS19740	COG4126	flavin adenine dinucleotide binding
HC645_RS19750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC645_RS19755	COG3416	Protein conserved in bacteria
HC645_RS19765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC645_RS19775	COG1785	Belongs to the alkaline phosphatase family
HC645_RS19815	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HC645_RS19820	COG1335	isochorismatase
HC645_RS19825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC645_RS19830	COG0113	porphobilinogen synthase activity
HC645_RS19835	COG1943	Transposase
HC645_RS19845	COG2175	clavaminate synthase activity
HC645_RS19850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC645_RS19855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HC645_RS19860	COG4521	taurine ABC transporter
HC645_RS19865	COG2040	homocysteine
HC645_RS19870	COG0833	amino acid
HC645_RS19885	COG4303	Ethanolamine ammonia lyase large subunit
HC645_RS19890	COG4302	ethanolamine ammonia-lyase activity
HC645_RS19930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS19935	COG1126	abc transporter atp-binding protein
HC645_RS19940	COG4597	amino acid ABC transporter
HC645_RS19945	COG0765	amino acid transport
HC645_RS19960	COG3188	usher protein
HC645_RS19985	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HC645_RS19995	COG3639	organic phosphonate transmembrane transporter activity
HC645_RS20015	COG0791	NLP P60 protein
HC645_RS20055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HC645_RS20065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC645_RS20120	COG3596	GTP binding
HC645_RS20130	COG2378	regulation of single-species biofilm formation
HC645_RS20160	COG2003	Belongs to the UPF0758 family
HC645_RS20175	COG1484	DNA-dependent DNA replication
HC645_RS20180	COG4584	PFAM Integrase catalytic
HC645_RS20200	COG2909	trisaccharide binding
HC645_RS20205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC645_RS20210	COG0022	dehydrogenase e1 component
HC645_RS20215	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC645_RS20220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC645_RS20240	COG1070	Carbohydrate kinase
HC645_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
HC645_RS20250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC645_RS20255	COG3775	system Galactitol-specific IIC component
HC645_RS20260	COG0625	glutathione transferase activity
HC645_RS20265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC645_RS20280	COG0579	oxidoreductase
HC645_RS20285	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS20290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC645_RS20295	COG1113	amino acid transport
HC645_RS20300	COG1802	Transcriptional regulator
HC645_RS20320	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC645_RS20325	COG0454	-acetyltransferase
HC645_RS20340	COG2991	Protein conserved in bacteria
HC645_RS20355	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HC645_RS20360	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HC645_RS20375	COG3034	peptidoglycan biosynthetic process
HC645_RS20380	COG0121	glutamine amidotransferase
HC645_RS20390	COG1960	acyl-CoA dehydrogenase activity
HC645_RS20395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC645_RS20405	COG0583	DNA-binding transcription factor activity
HC645_RS20415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC645_RS20425	COG2226	methyltransferase
HC645_RS20435	COG0741	lytic transglycosylase activity
HC645_RS20435	COG1388	LysM domain
HC645_RS20440	COG2226	methyltransferase
HC645_RS20450	COG2814	Major facilitator Superfamily
HC645_RS20455	COG0583	DNA-binding transcription factor activity
HC645_RS20460	COG0656	L-ascorbic acid biosynthetic process
HC645_RS20495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HC645_RS20505	COG2011	ABC-type metal ion transport system permease component
HC645_RS20510	COG1464	Belongs to the NlpA lipoprotein family
HC645_RS20520	COG1720	tRNA m6t6A37 methyltransferase activity
HC645_RS20530	COG0791	NLP P60 protein
HC645_RS20535	COG3015	lipoprotein NlpE involved in copper resistance
HC645_RS20540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC645_RS20555	COG4568	rho-dependent transcription termination
HC645_RS20565	COG0346	lactoylglutathione lyase activity
HC645_RS20580	COG0587	DNA-directed DNA polymerase activity
HC645_RS20610	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HC645_RS20620	COG0750	zinc metalloprotease
HC645_RS20625	COG0575	Belongs to the CDS family
HC645_RS20635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC645_RS20660	COG0024	Methionine aminopeptidase
HC645_RS20665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HC645_RS20680	COG3835	regulator
HC645_RS20685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC645_RS20705	COG2860	membrane
HC645_RS20725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS20730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC645_RS20735	COG1120	ATPase activity
HC645_RS20740	COG4774	siderophore transport
HC645_RS20745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC645_RS20840	COG1643	Atp-dependent helicase
HC645_RS20845	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC645_RS20865	COG0617	tRNA 3'-terminal CCA addition
HC645_RS20870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC645_RS20890	COG0726	polysaccharide deacetylase
HC645_RS20895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS20900	COG0842	Transport permease protein
HC645_RS20905	COG1131	(ABC) transporter
HC645_RS20910	COG0288	reversible hydration of carbon dioxide
HC645_RS20925	COG4993	Dehydrogenase
HC645_RS20930	COG2132	Multicopper oxidase
HC645_RS20980	COG3064	Membrane
HC645_RS20995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC645_RS21000	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC645_RS21005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HC645_RS21010	COG2186	Transcriptional regulator
HC645_RS21015	COG1113	amino acid transport
HC645_RS21020	COG2211	Major facilitator Superfamily
HC645_RS21025	COG3940	Belongs to the glycosyl hydrolase 43 family
HC645_RS21030	COG3725	Membrane protein required for beta-lactamase induction
HC645_RS21035	COG3023	N-Acetylmuramoyl-L-alanine amidase
HC645_RS21045	COG4969	Belongs to the N-Me-Phe pilin family
HC645_RS21050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC645_RS21055	COG1459	type II secretion system
HC645_RS21080	COG0494	nUDIX hydrolase
HC645_RS21100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC645_RS21105	COG0849	cell division
HC645_RS21130	COG0772	Belongs to the SEDS family
HC645_RS21145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC645_RS21150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC645_RS21155	COG0768	penicillin binding
HC645_RS21175	COG1609	Transcriptional regulator
HC645_RS21185	COG0028	Belongs to the TPP enzyme family
HC645_RS21235	COG0738	Major facilitator superfamily
HC645_RS21245	COG0583	DNA-binding transcription factor activity
HC645_RS21250	COG2271	Major facilitator Superfamily
HC645_RS21255	COG2814	Major facilitator Superfamily
HC645_RS21280	COG1178	ABC-type Fe3 transport system permease component
HC645_RS21290	COG0586	Pfam SNARE associated Golgi protein
HC645_RS21315	COG0235	Class ii aldolase
HC645_RS21320	COG0417	DNA replication proofreading
HC645_RS21330	COG0564	pseudouridine synthase activity
HC645_RS21355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HC645_RS21360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HC645_RS21370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HC645_RS21415	COG0505	Belongs to the CarA family
HC645_RS21485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC645_RS21510	COG1047	Peptidyl-prolyl cis-trans
HC645_RS21525	COG0196	riboflavin kinase activity
HC645_RS21545	COG0583	DNA-binding transcription factor activity
HC645_RS21570	COG4735	regulation of single-species biofilm formation
HC645_RS21575	COG1584	GPR1 FUN34 yaaH family protein
HC645_RS21580	COG0477	Major facilitator Superfamily
HC645_RS21585	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC645_RS21590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC645_RS21610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC645_RS21620	COG0527	aspartate kinase activity
HC645_RS21620	COG0460	homoserine dehydrogenase
HC645_RS21635	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HC645_RS21645	COG0745	RESPONSE REGULATOR receiver
HC645_RS21650	COG4452	Inner membrane protein CreD
HC645_RS21655	COG2205	protein histidine kinase activity
HC645_RS21660	COG0745	RESPONSE REGULATOR receiver
HC645_RS21665	COG3045	CreA protein
HC645_RS21670	COG2207	Transcriptional regulator
HC645_RS21670	COG3708	Transcriptional regulator
HC645_RS21690	COG0741	lytic transglycosylase activity
HC645_RS21695	COG0488	(ABC) transporter
HC645_RS21705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC645_RS21710	COG0560	Phosphoserine phosphatase
HC645_RS21715	COG3726	membrane protein affecting hemolysin expression
HC645_RS21745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC645_RS21750	COG0084	hydrolase, TatD family'
HC645_RS21755	COG4667	esterase of the alpha-beta hydrolase superfamily
HC645_RS21765	COG2823	Periplasmic or secreted lipoprotein
HC645_RS21775	COG1011	Hydrolase
HC645_RS21780	COG0456	acetyltransferase
HC645_RS21785	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HC645_RS21820	COG3706	GGDEF domain
HC645_RS21825	COG4114	ferric iron reductase
HC645_RS21830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS21830	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS21835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC645_RS21840	COG2197	response regulator
HC645_RS21845	COG2197	response regulator
HC645_RS21860	COG2966	Psort location CytoplasmicMembrane, score
HC645_RS21875	COG1484	DNA-dependent DNA replication
HC645_RS21890	COG5464	transposase or invertase
HC645_RS21900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC645_RS21905	COG3716	PTS system mannose fructose sorbose family IID component
HC645_RS21910	COG3715	PTS system
HC645_RS21925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC645_RS21925	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC645_RS21930	COG0456	acetyltransferase
HC645_RS21930	COG1214	PFAM Peptidase M22, glycoprotease
HC645_RS21940	COG1737	Transcriptional regulator
HC645_RS21945	COG0800	Aldolase
HC645_RS21950	COG3734	2-keto-3-deoxy-galactonokinase
HC645_RS21965	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HC645_RS21995	COG1846	Transcriptional regulator
HC645_RS22005	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC645_RS22015	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS22020	COG3384	dioxygenase
HC645_RS22030	COG3971	2-oxopent-4-enoate hydratase activity
HC645_RS22050	COG2368	4-hydroxyphenylacetate
HC645_RS22055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC645_RS22070	COG1966	Carbon starvation protein
HC645_RS22075	COG2879	small protein
HC645_RS22080	COG0523	cobalamin synthesis protein
HC645_RS22095	COG1012	belongs to the aldehyde dehydrogenase family
HC645_RS22100	COG5464	transposase or invertase
HC645_RS22105	COG1917	Cupin 2, conserved barrel domain protein
HC645_RS22105	COG2207	Transcriptional regulator
HC645_RS22115	COG2733	membrane
HC645_RS22130	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HC645_RS22135	COG1924	4 iron, 4 sulfur cluster binding
HC645_RS22150	COG1566	PFAM secretion protein HlyD family protein
HC645_RS22160	COG5457	Domain of unknown function (DUF1127)
HC645_RS22165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC645_RS22170	COG1715	Restriction endonuclease
HC645_RS22175	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HC645_RS22180	COG0732	type I restriction modification DNA specificity domain
HC645_RS22185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HC645_RS22200	COG0583	DNA-binding transcription factor activity
HC645_RS22205	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC645_RS22215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS22220	COG1129	ABC transporter
HC645_RS22225	COG1879	ABC-type sugar transport system periplasmic component
HC645_RS22235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS22240	COG1129	ABC transporter
HC645_RS22240	COG0842	Transport permease protein
HC645_RS22245	COG0842	Transport permease protein
HC645_RS22275	COG2850	peptidyl-arginine hydroxylation
HC645_RS22290	COG5002	protein histidine kinase activity
HC645_RS22295	COG0745	RESPONSE REGULATOR receiver
HC645_RS22300	COG1538	Outer membrane efflux protein
HC645_RS22305	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS22310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS22315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC645_RS22325	COG3040	lipid binding
HC645_RS22330	COG0789	Transcriptional regulator
HC645_RS22335	COG3631	Ketosteroid isomerase-related protein
HC645_RS22340	COG0300	oxidoreductase activity
HC645_RS22355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC645_RS22375	COG3272	Protein of unknown function (DUF1722)
HC645_RS22380	COG4580	involved in the transport of maltose and maltodextrins
HC645_RS22390	COG2211	Major facilitator Superfamily
HC645_RS22395	COG3507	Belongs to the glycosyl hydrolase 43 family
HC645_RS22415	COG1216	Glycosyl transferase, family 2
HC645_RS22465	COG2003	Belongs to the UPF0758 family
HC645_RS22490	COG2378	regulation of single-species biofilm formation
HC645_RS22495	COG3596	GTP binding
HC645_RS22500	COG1484	DNA-dependent DNA replication
HC645_RS22505	COG4584	PFAM Integrase catalytic
HC645_RS22540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HC645_RS22565	COG0582	viral genome integration into host DNA
HC645_RS22575	COG0288	reversible hydration of carbon dioxide
HC645_RS22580	COG0659	secondary active sulfate transmembrane transporter activity
HC645_RS22585	COG1064	alcohol dehydrogenase
HC645_RS22590	COG1175	transmembrane transport
HC645_RS22595	COG0395	ABC-type sugar transport system, permease component
HC645_RS22600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC645_RS22605	COG3842	ATPase activity
HC645_RS22620	COG1082	Xylose isomerase domain protein TIM barrel
HC645_RS22630	COG3962	Belongs to the TPP enzyme family
HC645_RS22640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS22645	COG0837	glucose binding
HC645_RS22645	COG1737	Transcriptional regulator
HC645_RS22650	COG3718	enzyme involved in inositol metabolism
HC645_RS22665	COG0433	COG0433 Predicted ATPase
HC645_RS22670	COG0795	lipopolysaccharide-transporting ATPase activity
HC645_RS22675	COG0795	lipopolysaccharide-transporting ATPase activity
HC645_RS22685	COG2927	DNA polymerase III (CHI subunit)
HC645_RS22690	COG0525	valine-tRNA ligase activity
HC645_RS22715	COG2731	YhcH YjgK YiaL family protein
HC645_RS22750	COG1263	PTS System
HC645_RS22750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC645_RS22755	COG0366	Alpha amylase catalytic
HC645_RS22760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC645_RS22765	COG1486	melibiose metabolic process
HC645_RS22790	COG0602	queuosine metabolic process
HC645_RS22795	COG2026	Addiction module toxin, RelE StbE family
HC645_RS22800	COG3077	Addiction module antitoxin, RelB DinJ family
HC645_RS22805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC645_RS22805	COG3711	transcriptional antiterminator
HC645_RS22810	COG2706	6-phosphogluconolactonase activity
HC645_RS22825	COG3964	amidohydrolase
HC645_RS22865	COG0312	modulator of DNA gyrase
HC645_RS22890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC645_RS22900	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS22905	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS22910	COG1129	ABC transporter
HC645_RS22915	COG1879	ABC-type sugar transport system periplasmic component
HC645_RS22935	COG2105	PFAM AIG2 family protein
HC645_RS22940	COG2911	Protein conserved in bacteria
HC645_RS22945	COG0729	surface antigen
HC645_RS22955	COG1253	flavin adenine dinucleotide binding
HC645_RS22980	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HC645_RS22995	COG1733	regulation of RNA biosynthetic process
HC645_RS23000	COG0702	epimerase
HC645_RS23010	COG0697	spore germination
HC645_RS23020	COG1113	amino acid transport
HC645_RS23025	COG0545	Peptidyl-prolyl cis-trans isomerase
HC645_RS23030	COG3061	Opacity-associated protein A
HC645_RS23040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC645_RS23045	COG2965	DNA replication, synthesis of RNA primer
HC645_RS23105	COG1073	alpha beta
HC645_RS23110	COG3650	response to hydrogen peroxide
HC645_RS23120	COG1960	acyl-CoA dehydrogenase activity
HC645_RS23125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC645_RS23130	COG0557	exoribonuclease II activity
HC645_RS23145	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HC645_RS23155	COG0330	HflC and HflK could
HC645_RS23160	COG0330	HflC and HflK could
HC645_RS23165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC645_RS23190	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC645_RS23195	COG0802	atpase or kinase
HC645_RS23200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC645_RS23200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HC645_RS23205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC645_RS23225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC645_RS23245	COG3264	Mechanosensitive ion channel
HC645_RS23245	COG1511	domain protein
HC645_RS23260	COG1053	succinate dehydrogenase
HC645_RS23265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC645_RS23285	COG2076	Multidrug Resistance protein
HC645_RS23290	COG5510	response to toxic substance
HC645_RS23305	COG1509	lysine 2,3-aminomutase activity
HC645_RS23310	COG0745	RESPONSE REGULATOR receiver
HC645_RS23345	COG3188	usher protein
HC645_RS23350	COG3539	Fimbrial protein
HC645_RS23370	COG0531	amino acid
HC645_RS23375	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC645_RS23380	COG1027	Aspartate ammonia-lyase
HC645_RS23385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HC645_RS23400	COG1309	transcriptional regulator
HC645_RS23440	COG0457	Tetratricopeptide repeat
HC645_RS23445	COG0726	polysaccharide deacetylase
HC645_RS23445	COG1649	PFAM Uncharacterised BCR, COG1649
HC645_RS23450	COG1215	transferase activity, transferring glycosyl groups
HC645_RS23470	COG0861	Integral membrane protein TerC family
HC645_RS23510	COG1486	melibiose metabolic process
HC645_RS23515	COG2169	Transcriptional regulator
HC645_RS23525	COG2824	Alkylphosphonate utilization operon protein PhnA
HC645_RS23530	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HC645_RS23535	COG2188	Transcriptional regulator
HC645_RS23540	COG3624	Phosphonate C-P lyase system protein PhnG
HC645_RS23545	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HC645_RS23550	COG3626	phosphonate metabolism
HC645_RS23555	COG3627	carbon phosphorus lyase activity
HC645_RS23560	COG4107	phosphonate C-P lyase system protein PhnK
HC645_RS23565	COG4778	phosphonate C-P lyase system protein PhnL
HC645_RS23570	COG3454	Phosphonate metabolism
HC645_RS23580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC645_RS23590	COG0784	Response regulator, receiver
HC645_RS23590	COG4191	Histidine kinase
HC645_RS23595	COG1129	ABC transporter
HC645_RS23600	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS23635	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HC645_RS23640	COG1301	dicarboxylic acid transport
HC645_RS23650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC645_RS23655	COG3162	membrane
HC645_RS23685	COG3539	Fimbrial protein
HC645_RS23695	COG1346	cytolysis
HC645_RS23700	COG1380	Effector of murein hydrolase LrgA
HC645_RS23705	COG0583	DNA-binding transcription factor activity
HC645_RS23710	COG0025	NhaP-type Na H and K H
HC645_RS23715	COG2252	PERMEase
HC645_RS23720	COG0625	glutathione transferase activity
HC645_RS23725	COG0789	Transcriptional regulator
HC645_RS23735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HC645_RS23765	COG1234	tRNA 3'-trailer cleavage
HC645_RS23770	COG1609	Transcriptional regulator
HC645_RS23775	COG0483	inositol monophosphate 1-phosphatase activity
HC645_RS23785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC645_RS23810	COG4771	TonB-dependent receptor
HC645_RS23825	COG0741	lytic transglycosylase activity
HC645_RS23850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HC645_RS23925	COG2315	Protein conserved in bacteria
HC645_RS23930	COG0432	Pfam Uncharacterised protein family UPF0047
HC645_RS23945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC645_RS23950	COG0305	Participates in initiation and elongation during chromosome replication
HC645_RS23965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC645_RS23975	COG0735	belongs to the Fur family
HC645_RS23980	COG3237	CsbD-like
HC645_RS23985	COG0534	Mate efflux family protein
HC645_RS23995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC645_RS24065	COG0251	oxidation-reduction process
HC645_RS24075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC645_RS24085	COG0527	aspartate kinase activity
HC645_RS24140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC645_RS24170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HC645_RS24180	COG0456	acetyltransferase
HC645_RS24210	COG0151	Belongs to the GarS family
HC645_RS24220	COG4191	Histidine kinase
HC645_RS24225	COG3678	ATP-independent chaperone mediated protein folding
HC645_RS24260	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HC645_RS24275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC645_RS24280	COG2104	thiamine diphosphate biosynthetic process
HC645_RS24295	COG3706	GGDEF domain
HC645_RS24305	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC645_RS24310	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HC645_RS24345	COG0250	Participates in transcription elongation, termination and antitermination
HC645_RS24420	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HC645_RS24430	COG1739	Uncharacterized protein family UPF0029
HC645_RS24475	COG0805	protein transport
HC645_RS24495	COG3165	ubiquinone biosynthetic process from chorismate
HC645_RS24525	COG0583	DNA-binding transcription factor activity
HC645_RS24530	COG0697	spore germination
HC645_RS24535	COG0561	phosphatase activity
HC645_RS24540	COG2267	carboxylic ester hydrolase activity
HC645_RS24545	COG1280	lysine exporter protein (LysE YggA)
HC645_RS24555	COG1280	lysine exporter protein (LysE YggA)
HC645_RS24585	COG0210	DNA helicase
HC645_RS24590	COG1011	Hydrolase
HC645_RS24620	COG3072	Adenylate cyclase
HC645_RS24635	COG2959	enzyme of heme biosynthesis
HC645_RS24640	COG3071	HemY protein
HC645_RS24690	COG2244	polysaccharide biosynthetic process
HC645_RS24695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC645_RS24700	COG0456	acetyltransferase
HC645_RS24705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC645_RS24710	COG1088	dTDP-glucose 4,6-dehydratase activity
HC645_RS24715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HC645_RS24720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC645_RS24730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC645_RS24735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC645_RS24740	COG3118	belongs to the thioredoxin family
HC645_RS24765	COG1811	Na channel or pump
HC645_RS24775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC645_RS24780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC645_RS24790	COG0583	DNA-binding transcription factor activity
HC645_RS24795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC645_RS24810	COG3978	acetolactate synthase activity
HC645_RS24830	COG3085	chromosome segregation
HC645_RS24905	COG0583	DNA-binding transcription factor activity
HC645_RS24920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC645_RS24935	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC645_RS24940	COG2207	Transcriptional regulator
HC645_RS24950	COG0371	Dehydrogenase
HC645_RS24955	COG0697	spore germination
HC645_RS24965	COG0583	DNA-binding transcription factor activity
HC645_RS24975	COG0737	Belongs to the 5'-nucleotidase family
HC645_RS24985	COG0460	homoserine dehydrogenase
HC645_RS24985	COG0527	aspartate kinase activity
HC645_RS24990	COG0626	cystathionine gamma-synthase activity
HC645_RS25005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC645_RS25010	COG1609	Transcriptional regulator
HC645_RS25015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC645_RS25030	COG1575	Belongs to the MenA family. Type 1 subfamily
HC645_RS25050	COG3678	ATP-independent chaperone mediated protein folding
HC645_RS25055	COG0745	RESPONSE REGULATOR receiver
HC645_RS25060	COG2205	protein histidine kinase activity
HC645_RS25065	COG2258	MOSC domain
HC645_RS25070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC645_RS25110	COG1129	ABC transporter
HC645_RS25115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS25120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS25135	COG2211	Major facilitator Superfamily
HC645_RS25180	COG0437	4 iron, 4 sulfur cluster binding
HC645_RS25185	COG2864	formate dehydrogenase
HC645_RS25200	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HC645_RS25210	COG0456	acetyltransferase
HC645_RS25225	COG1011	Hydrolase
HC645_RS25240	COG3852	Histidine kinase
HC645_RS25255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC645_RS25275	COG0204	Acyl-transferase
HC645_RS25285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC645_RS25290	COG3084	Protein conserved in bacteria
HC645_RS25300	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC645_RS25325	COG2186	Transcriptional regulator
HC645_RS25330	COG0477	Major facilitator Superfamily
HC645_RS25335	COG1609	Transcriptional regulator
HC645_RS25340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC645_RS25350	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC645_RS25355	COG1129	ABC transporter
HC645_RS25385	COG1522	sequence-specific DNA binding
HC645_RS25390	COG0716	FMN binding
HC645_RS25405	COG3312	ion transport
HC645_RS25470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC645_RS25475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC645_RS25480	COG0573	inorganic phosphate transmembrane transporter activity
HC645_RS25485	COG0581	inorganic phosphate transmembrane transporter activity
HC645_RS25490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC645_RS25495	COG0704	Plays a role in the regulation of phosphate uptake
HC645_RS25510	COG2382	esterase
HC645_RS25515	COG0363	glucosamine-6-phosphate deaminase activity
HC645_RS25520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC645_RS25530	COG2252	PERMEase
HC645_RS25535	COG0431	NADPH-dependent FMN reductase
HC645_RS25540	COG2091	lysine biosynthetic process via aminoadipic acid
HC645_RS25570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC645_RS25585	COG1276	copper resistance
HC645_RS25590	COG2372	response to copper ion
HC645_RS25595	COG3667	copper resistance
HC645_RS25600	COG2132	Multicopper oxidase
HC645_RS25610	COG0739	heme binding
HC645_RS25640	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC645_RS25680	COG3706	GGDEF domain
HC645_RS25700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC645_RS25730	COG0431	NADPH-dependent FMN reductase
HC645_RS25755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC645_RS25765	COG1595	DNA-templated transcription, initiation
HC645_RS25770	COG3712	iron ion homeostasis
HC645_RS25775	COG4772	TonB-dependent receptor
HC645_RS25780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC645_RS25785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS25790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC645_RS25795	COG1120	ATPase activity
HC645_RS25800	COG3436	PFAM IS66 Orf2 family protein
HC645_RS25825	COG0640	Transcriptional regulator
HC645_RS25830	COG0431	NADPH-dependent FMN reductase
HC645_RS25885	COG2223	nitrite transmembrane transporter activity
HC645_RS25915	COG0418	dihydroorotase activity
HC645_RS25930	COG0543	2 iron, 2 sulfur cluster binding
HC645_RS25935	COG2814	Major facilitator Superfamily
HC645_RS25945	COG3039	Transposase
HC645_RS25950	COG2372	response to copper ion
HC645_RS26005	COG5654	RES domain protein
HC645_RS26010	COG5642	Protein of unknown function (DUF2384)
HC645_RS26040	COG1609	Transcriptional regulator
HC645_RS26050	COG2223	nitrite transmembrane transporter activity
HC645_RS26125	COG3436	PFAM IS66 Orf2 family protein
HC645_RS26130	COG4372	Transposase
HC645_RS26240	COG4680	protein conserved in bacteria
HC645_RS26245	COG5499	transcription regulator containing HTH domain
HC645_RS26285	COG2801	Transposase and inactivated derivatives
HC645_RS26300	COG1484	DNA-dependent DNA replication
HC645_RS26305	COG4584	PFAM Integrase catalytic
HC645_RS26340	COG4598	ABC transporter
HC645_RS26360	COG0583	DNA-binding transcription factor activity
HC645_RS26380	COG3436	PFAM IS66 Orf2 family protein
HC645_RS26395	COG2205	protein histidine kinase activity
HC645_RS26400	COG0745	RESPONSE REGULATOR receiver