locus-tag	class	description
I5M60_RS00030	COG1609	Transcriptional regulator
I5M60_RS00040	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS00055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5M60_RS00065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M60_RS00070	COG0583	DNA-binding transcription factor activity
I5M60_RS00075	COG0583	DNA-binding transcription factor activity
I5M60_RS00090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M60_RS00090	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M60_RS00090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M60_RS00095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M60_RS00105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M60_RS00110	COG3037	sugar-specific permease SgaT UlaA
I5M60_RS00120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS00125	COG1609	Transcriptional regulator
I5M60_RS00135	COG2223	nitrite transmembrane transporter activity
I5M60_RS00165	COG0477	Major facilitator Superfamily
I5M60_RS00170	COG4529	Protein conserved in bacteria
I5M60_RS00175	COG1902	pentaerythritol trinitrate reductase activity
I5M60_RS00185	COG0583	DNA-binding transcription factor activity
I5M60_RS00190	COG2070	2-Nitropropane dioxygenase
I5M60_RS00200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5M60_RS00210	COG0765	amino acid transport
I5M60_RS00280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M60_RS00310	COG1335	isochorismatase
I5M60_RS00315	COG0406	alpha-ribazole phosphatase activity
I5M60_RS00355	COG1953	Uracil, thiamine, allantoin
I5M60_RS00360	COG0402	S-adenosylhomocysteine deaminase activity
I5M60_RS00365	COG3706	GGDEF domain
I5M60_RS00370	COG1609	Transcriptional regulator
I5M60_RS00380	COG0673	inositol 2-dehydrogenase activity
I5M60_RS00395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5M60_RS00400	COG1116	anion transmembrane transporter activity
I5M60_RS00405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M60_RS00410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M60_RS00415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M60_RS00420	COG0076	glutamate decarboxylase activity
I5M60_RS00435	COG2205	protein histidine kinase activity
I5M60_RS00445	COG0596	Alpha beta hydrolase
I5M60_RS00485	COG0519	Catalyzes the synthesis of GMP from XMP
I5M60_RS00485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5M60_RS00505	COG0583	DNA-binding transcription factor activity
I5M60_RS00515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M60_RS00520	COG1285	pathogenesis
I5M60_RS00525	COG2814	Major facilitator Superfamily
I5M60_RS00530	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M60_RS00535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS00560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS00565	COG0583	DNA-binding transcription factor activity
I5M60_RS00570	COG0243	molybdopterin cofactor binding
I5M60_RS00575	COG3781	membrane
I5M60_RS00600	COG1764	response to oxidative stress
I5M60_RS00610	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M60_RS00620	COG2323	membrane
I5M60_RS00630	COG0366	Alpha amylase catalytic
I5M60_RS00640	COG3685	Protein conserved in bacteria
I5M60_RS00650	COG3729	General stress protein
I5M60_RS00655	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS00700	COG0488	(ABC) transporter
I5M60_RS00715	COG1064	alcohol dehydrogenase
I5M60_RS00720	COG0747	negative chemotaxis
I5M60_RS00730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M60_RS00740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M60_RS00750	COG2814	Major facilitator Superfamily
I5M60_RS00760	COG2326	polyphosphate kinase activity
I5M60_RS00775	COG2864	formate dehydrogenase
I5M60_RS00780	COG0437	4 iron, 4 sulfur cluster binding
I5M60_RS00805	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5M60_RS00815	COG3485	protocatechuate 3,4-dioxygenase
I5M60_RS00820	COG4829	muconolactone delta-isomerase
I5M60_RS00825	COG4948	Mandelate Racemase Muconate Lactonizing
I5M60_RS00830	COG1414	Transcriptional regulator
I5M60_RS00850	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M60_RS00855	COG1140	nitrate reductase beta subunit
I5M60_RS00860	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M60_RS00865	COG2181	nitrate reductase activity
I5M60_RS00870	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I5M60_RS00875	COG1178	ABC-type Fe3 transport system permease component
I5M60_RS00880	COG1840	ABC-type Fe3 transport system, periplasmic component
I5M60_RS00885	COG3842	ATPase activity
I5M60_RS00890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M60_RS00925	COG0625	glutathione transferase activity
I5M60_RS00935	COG1126	abc transporter atp-binding protein
I5M60_RS00940	COG0765	amino acid transport
I5M60_RS00950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS00955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M60_RS00960	COG1473	amidohydrolase
I5M60_RS00965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M60_RS00970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M60_RS00995	COG4772	TonB-dependent receptor
I5M60_RS01000	COG1228	amidohydrolase
I5M60_RS01005	COG3691	Protein conserved in bacteria
I5M60_RS01020	COG2130	NADP-dependent
I5M60_RS01030	COG1247	-acetyltransferase
I5M60_RS01035	COG3238	Protein conserved in bacteria
I5M60_RS01045	COG0747	negative chemotaxis
I5M60_RS01050	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS01085	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS01090	COG1177	transmembrane transport
I5M60_RS01095	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M60_RS01100	COG3842	ATPase activity
I5M60_RS01105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M60_RS01110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M60_RS01115	COG1271	oxidase subunit
I5M60_RS01120	COG1294	oxidase, subunit
I5M60_RS01140	COG0826	peptidase U32
I5M60_RS01150	COG1396	sequence-specific DNA binding
I5M60_RS01155	COG3135	benzoate transporter
I5M60_RS01160	COG3708	Transcriptional regulator
I5M60_RS01160	COG2207	Transcriptional regulator
I5M60_RS01175	COG0500	methyltransferase
I5M60_RS01180	COG1275	C4-dicarboxylate transporter malic acid transport protein
I5M60_RS01185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M60_RS01190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M60_RS01205	COG2272	Belongs to the type-B carboxylesterase lipase family
I5M60_RS01210	COG5383	Protein conserved in bacteria
I5M60_RS01215	COG3485	protocatechuate 3,4-dioxygenase
I5M60_RS01220	COG3485	protocatechuate 3,4-dioxygenase
I5M60_RS01225	COG0583	DNA-binding transcription factor activity
I5M60_RS01245	COG3038	cytochrome b561
I5M60_RS01265	COG2814	Major facilitator Superfamily
I5M60_RS01275	COG0673	inositol 2-dehydrogenase activity
I5M60_RS01285	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS01320	COG4659	FMN binding
I5M60_RS01330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5M60_RS01340	COG0625	glutathione transferase activity
I5M60_RS01345	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5M60_RS01360	COG3895	Periplasmic Protein
I5M60_RS01375	COG3706	GGDEF domain
I5M60_RS01390	COG1566	PFAM secretion protein HlyD family protein
I5M60_RS01395	COG1289	transmembrane transporter activity
I5M60_RS01400	COG2032	superoxide dismutase activity
I5M60_RS01405	COG4989	oxidoreductase activity
I5M60_RS01410	COG3313	Fe-S protein
I5M60_RS01415	COG1309	transcriptional regulator
I5M60_RS01420	COG1902	pentaerythritol trinitrate reductase activity
I5M60_RS01425	COG0346	lactoylglutathione lyase activity
I5M60_RS01435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5M60_RS01440	COG0791	NLP P60 protein
I5M60_RS01455	COG2814	Major facilitator Superfamily
I5M60_RS01470	COG0583	DNA-binding transcription factor activity
I5M60_RS01475	COG2814	Major facilitator Superfamily
I5M60_RS01480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M60_RS01485	COG0307	riboflavin synthase, alpha
I5M60_RS01535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5M60_RS01570	COG1349	DNA-binding transcription factor activity
I5M60_RS01575	COG0346	lactoylglutathione lyase activity
I5M60_RS01600	COG0444	Belongs to the ABC transporter superfamily
I5M60_RS01605	COG4608	Belongs to the ABC transporter superfamily
I5M60_RS01635	COG0604	alcohol dehydrogenase
I5M60_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS01635	COG3321	synthase
I5M60_RS01675	COG0402	S-adenosylhomocysteine deaminase activity
I5M60_RS01700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M60_RS01705	COG0277	FAD linked oxidase domain protein
I5M60_RS01730	COG0583	DNA-binding transcription factor activity
I5M60_RS01740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M60_RS01750	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M60_RS01755	COG2610	gluconate transmembrane transporter activity
I5M60_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS01795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M60_RS01810	COG0745	RESPONSE REGULATOR receiver
I5M60_RS01815	COG5002	protein histidine kinase activity
I5M60_RS01815	COG3850	Histidine kinase
I5M60_RS01830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5M60_RS01850	COG3088	subunit of a heme lyase
I5M60_RS01850	COG4235	cytochrome complex assembly
I5M60_RS01855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M60_RS01860	COG1138	Cytochrome C-type biogenesis protein
I5M60_RS01875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M60_RS01880	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M60_RS01885	COG4133	protoheme IX ABC transporter activity
I5M60_RS01915	COG1175	transmembrane transport
I5M60_RS01925	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5M60_RS01930	COG3383	formate dehydrogenase (NAD+) activity
I5M60_RS01970	COG1126	abc transporter atp-binding protein
I5M60_RS01975	COG0765	amino acid transport
I5M60_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS02000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS02005	COG1120	ATPase activity
I5M60_RS02010	COG4774	siderophore transport
I5M60_RS02015	COG1116	anion transmembrane transporter activity
I5M60_RS02020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M60_RS02040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M60_RS02045	COG0583	DNA-binding transcription factor activity
I5M60_RS02065	COG2814	Major facilitator Superfamily
I5M60_RS02100	COG1414	Transcriptional regulator
I5M60_RS02105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M60_RS02110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS02115	COG1120	ATPase activity
I5M60_RS02125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M60_RS02130	COG2271	Major facilitator Superfamily
I5M60_RS02135	COG1082	Xylose isomerase domain protein TIM barrel
I5M60_RS02135	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I5M60_RS02140	COG1309	transcriptional regulator
I5M60_RS02170	COG1376	ErfK ybiS ycfS ynhG family protein
I5M60_RS02185	COG0719	Fe-S assembly protein
I5M60_RS02190	COG0396	ATPase activity
I5M60_RS02195	COG0719	Fe-S assembly protein
I5M60_RS02200	COG0316	Belongs to the HesB IscA family
I5M60_RS02220	COG1309	transcriptional regulator
I5M60_RS02225	COG1304	FMN binding
I5M60_RS02250	COG0583	DNA-binding transcription factor activity
I5M60_RS02260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS02265	COG1120	ATPase activity
I5M60_RS02290	COG2261	transglycosylase associated protein
I5M60_RS02295	COG2050	protein possibly involved in aromatic compounds catabolism
I5M60_RS02300	COG0277	FAD linked oxidase domain protein
I5M60_RS02300	COG0247	lactate metabolic process
I5M60_RS02305	COG0628	permease
I5M60_RS02315	COG0574	Belongs to the PEP-utilizing enzyme family
I5M60_RS02315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5M60_RS02330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M60_RS02335	COG4256	Hemin uptake protein
I5M60_RS02345	COG0791	NLP P60 protein
I5M60_RS02355	COG0386	Belongs to the glutathione peroxidase family
I5M60_RS02375	COG0583	DNA-binding transcription factor activity
I5M60_RS02395	COG0072	phenylalanine-tRNA ligase activity
I5M60_RS02395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M60_RS02435	COG3137	Salt-induced outer membrane protein
I5M60_RS02440	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M60_RS02450	COG3001	Fructosamine kinase
I5M60_RS02460	COG2350	Protein conserved in bacteria
I5M60_RS02470	COG2353	YceI-like domain
I5M60_RS02490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M60_RS02500	COG0444	Belongs to the ABC transporter superfamily
I5M60_RS02505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M60_RS02510	COG0601	transmembrane transport
I5M60_RS02515	COG4166	transmembrane transport
I5M60_RS02520	COG2095	MarC family integral membrane protein
I5M60_RS02530	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS02530	COG1454	alcohol dehydrogenase
I5M60_RS02535	COG1435	thymidine kinase activity
I5M60_RS02545	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M60_RS02550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5M60_RS02555	COG0745	RESPONSE REGULATOR receiver
I5M60_RS02560	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5M60_RS02570	COG0788	formyltetrahydrofolate deformylase activity
I5M60_RS02605	COG1522	sequence-specific DNA binding
I5M60_RS02615	COG2181	nitrate reductase activity
I5M60_RS02620	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M60_RS02625	COG1140	nitrate reductase beta subunit
I5M60_RS02630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M60_RS02640	COG2223	nitrite transmembrane transporter activity
I5M60_RS02645	COG3850	Histidine kinase
I5M60_RS02650	COG2197	response regulator
I5M60_RS02655	COG4932	domain protein
I5M60_RS02660	COG0243	molybdopterin cofactor binding
I5M60_RS02665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M60_RS02665	COG2146	nitrite reductase [NAD(P)H] activity
I5M60_RS02670	COG1116	anion transmembrane transporter activity
I5M60_RS02680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M60_RS02685	COG3707	response regulator
I5M60_RS02690	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I5M60_RS02700	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I5M60_RS02705	COG4572	Cation transport regulator
I5M60_RS02710	COG0387	Pfam Sodium calcium exchanger
I5M60_RS02730	COG2890	protein-(glutamine-N5) methyltransferase activity
I5M60_RS02760	COG0659	secondary active sulfate transmembrane transporter activity
I5M60_RS02780	COG0012	GTP binding
I5M60_RS02870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5M60_RS02940	COG2885	chlorophyll binding
I5M60_RS02960	COG3122	Protein conserved in bacteria
I5M60_RS02975	COG0583	DNA-binding transcription factor activity
I5M60_RS03005	COG0583	DNA-binding transcription factor activity
I5M60_RS03040	COG1882	Formate acetyltransferase
I5M60_RS03055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M60_RS03060	COG0583	DNA-binding transcription factor activity
I5M60_RS03100	COG2308	Evidence 4 Homologs of previously reported genes of
I5M60_RS03115	COG4774	siderophore transport
I5M60_RS03125	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5M60_RS03150	COG2719	SpoVR family
I5M60_RS03180	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M60_RS03195	COG2894	cell division
I5M60_RS03205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I5M60_RS03215	COG3065	identical protein binding
I5M60_RS03225	COG1199	ATP-dependent helicase activity
I5M60_RS03230	COG0251	oxidation-reduction process
I5M60_RS03250	COG1760	l-serine dehydratase
I5M60_RS03255	COG2200	EAL domain
I5M60_RS03260	COG1253	flavin adenine dinucleotide binding
I5M60_RS03265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M60_RS03265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS03270	COG3715	PTS system
I5M60_RS03275	COG3716	PTS system mannose fructose sorbose family IID component
I5M60_RS03290	COG2226	methyltransferase
I5M60_RS03295	COG0768	penicillin binding
I5M60_RS03325	COG1414	Transcriptional regulator
I5M60_RS03330	COG2814	Major facilitator Superfamily
I5M60_RS03350	COG1956	GAF domain-containing protein
I5M60_RS03355	COG2995	paraquat-inducible protein a
I5M60_RS03360	COG3008	intermembrane lipid transfer
I5M60_RS03385	COG2990	Protein conserved in bacteria
I5M60_RS03400	COG1276	copper resistance
I5M60_RS03405	COG2372	response to copper ion
I5M60_RS03415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M60_RS03420	COG1770	oligopeptidase
I5M60_RS03425	COG2979	Protein of unknown function (DUF533)
I5M60_RS03430	COG3141	response to X-ray
I5M60_RS03440	COG0800	Aldolase
I5M60_RS03445	COG0129	dihydroxy-acid dehydratase activity
I5M60_RS03450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5M60_RS03460	COG1737	Transcriptional regulator
I5M60_RS03470	COG1560	Kdo2-lipid A biosynthetic process
I5M60_RS03475	COG0739	heme binding
I5M60_RS03480	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5M60_RS03490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M60_RS03515	COG0494	nUDIX hydrolase
I5M60_RS03525	COG1335	isochorismatase
I5M60_RS03530	COG1801	Protein of unknown function DUF72
I5M60_RS03535	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I5M60_RS03555	COG3102	Protein conserved in bacteria
I5M60_RS03565	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I5M60_RS03590	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS03600	COG1879	ABC-type sugar transport system periplasmic component
I5M60_RS03610	COG1528	Iron-storage protein
I5M60_RS03620	COG2211	Major facilitator Superfamily
I5M60_RS03630	COG0477	Major facilitator Superfamily
I5M60_RS03645	COG1528	Iron-storage protein
I5M60_RS03655	COG0814	amino acid
I5M60_RS03660	COG3318	Belongs to the UPF0149 family
I5M60_RS03660	COG3012	SEC-C Motif Domain Protein
I5M60_RS03695	COG2197	response regulator
I5M60_RS03705	COG2197	response regulator
I5M60_RS03710	COG1126	abc transporter atp-binding protein
I5M60_RS03715	COG0765	amino acid transport
I5M60_RS03725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS03730	COG0366	Alpha amylase catalytic
I5M60_RS03760	COG2354	Protein conserved in bacteria
I5M60_RS03765	COG0697	spore germination
I5M60_RS03770	COG3727	T/G mismatch-specific endonuclease activity
I5M60_RS03775	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5M60_RS03780	COG1418	mRNA catabolic process
I5M60_RS03790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M60_RS03840	COG0582	viral genome integration into host DNA
I5M60_RS03945	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M60_RS03980	COG0025	NhaP-type Na H and K H
I5M60_RS03985	COG1309	transcriptional regulator
I5M60_RS03990	COG0604	alcohol dehydrogenase
I5M60_RS04010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5M60_RS04020	COG0534	Mate efflux family protein
I5M60_RS04030	COG0582	viral genome integration into host DNA
I5M60_RS04040	COG1121	(ABC) transporter
I5M60_RS04045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M60_RS04050	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5M60_RS04080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5M60_RS04090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5M60_RS04095	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5M60_RS04105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M60_RS04135	COG0523	cobalamin synthesis protein
I5M60_RS04160	COG0523	cobalamin synthesis protein
I5M60_RS04170	COG0735	belongs to the Fur family
I5M60_RS04175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS04190	COG0582	viral genome integration into host DNA
I5M60_RS04195	COG1169	isochorismate synthase
I5M60_RS04200	COG2814	Major facilitator Superfamily
I5M60_RS04205	COG1132	(ABC) transporter
I5M60_RS04220	COG3433	isochorismatase activity
I5M60_RS04220	COG2226	methyltransferase
I5M60_RS04220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5M60_RS04240	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5M60_RS04245	COG4771	TonB-dependent receptor
I5M60_RS04325	COG3504	Conjugal transfer protein
I5M60_RS04365	COG4227	nucleotidyltransferase activity
I5M60_RS04380	COG0758	DNA mediated transformation
I5M60_RS04440	COG3615	Tellurite resistance protein tehB
I5M60_RS04450	COG5001	Diguanylate cyclase
I5M60_RS04450	COG3300	MHYT domain
I5M60_RS04460	COG0477	Major facilitator Superfamily
I5M60_RS04465	COG0095	Lipoate-protein ligase
I5M60_RS04470	COG0583	DNA-binding transcription factor activity
I5M60_RS04475	COG1942	4-Oxalocrotonate Tautomerase
I5M60_RS04485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5M60_RS04505	COG1289	transmembrane transporter activity
I5M60_RS04515	COG3344	reverse transcriptase
I5M60_RS04525	COG2925	Exonuclease
I5M60_RS04530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5M60_RS04535	COG0640	Transcriptional regulator
I5M60_RS04540	COG0531	amino acid
I5M60_RS04555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M60_RS04585	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5M60_RS04610	COG0438	transferase activity, transferring glycosyl groups
I5M60_RS04680	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M60_RS04715	COG0438	transferase activity, transferring glycosyl groups
I5M60_RS04725	COG1216	Glycosyl transferase, family 2
I5M60_RS04725	COG1442	glycosyl transferase family 8
I5M60_RS04780	COG1253	flavin adenine dinucleotide binding
I5M60_RS04785	COG2982	Protein involved in outer membrane biogenesis
I5M60_RS04800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5M60_RS04805	COG0443	Heat shock 70 kDa protein
I5M60_RS04810	COG5002	protein histidine kinase activity
I5M60_RS04830	COG1301	dicarboxylic acid transport
I5M60_RS04855	COG2205	protein histidine kinase activity
I5M60_RS04860	COG0745	RESPONSE REGULATOR receiver
I5M60_RS04865	COG0826	peptidase U32
I5M60_RS04875	COG4608	Belongs to the ABC transporter superfamily
I5M60_RS04880	COG0444	Belongs to the ABC transporter superfamily
I5M60_RS04885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M60_RS04890	COG0601	transmembrane transport
I5M60_RS04895	COG0747	negative chemotaxis
I5M60_RS04900	COG4948	Mandelate Racemase Muconate Lactonizing
I5M60_RS04905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M60_RS04915	COG1070	Carbohydrate kinase
I5M60_RS04950	COG1830	Aldolase
I5M60_RS04955	COG0351	phosphomethylpyrimidine kinase
I5M60_RS04970	COG0583	DNA-binding transcription factor activity
I5M60_RS04980	COG2252	PERMEase
I5M60_RS04985	COG0583	DNA-binding transcription factor activity
I5M60_RS04990	COG5455	response to cobalt ion
I5M60_RS05010	COG4807	Protein conserved in bacteria
I5M60_RS05020	COG3275	phosphorelay sensor kinase activity
I5M60_RS05030	COG1174	glycine betaine transport
I5M60_RS05035	COG1125	glycine betaine transport
I5M60_RS05040	COG1174	glycine betaine transport
I5M60_RS05045	COG1732	Glycine betaine
I5M60_RS05050	COG1472	Belongs to the glycosyl hydrolase 3 family
I5M60_RS05055	COG0277	FAD linked oxidase domain protein
I5M60_RS05065	COG1686	Belongs to the peptidase S11 family
I5M60_RS05075	COG0586	Pfam SNARE associated Golgi protein
I5M60_RS05080	COG1538	Outer membrane efflux protein
I5M60_RS05085	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS05100	COG3659	wide pore channel activity
I5M60_RS05105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M60_RS05115	COG1346	cytolysis
I5M60_RS05125	COG2949	membrane
I5M60_RS05135	COG1129	ABC transporter
I5M60_RS05150	COG2311	Membrane
I5M60_RS05165	COG4771	TonB-dependent receptor
I5M60_RS05170	COG0833	amino acid
I5M60_RS05175	COG0583	DNA-binding transcription factor activity
I5M60_RS05180	COG2855	membrane
I5M60_RS05190	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M60_RS05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M60_RS05190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M60_RS05195	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M60_RS05200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS05200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS05225	COG1312	Catalyzes the dehydration of D-mannonate
I5M60_RS05230	COG0246	Mannitol dehydrogenase
I5M60_RS05235	COG0523	cobalamin synthesis protein
I5M60_RS05240	COG0671	phosphoesterase, PA-phosphatase related
I5M60_RS05245	COG0791	NLP P60 protein
I5M60_RS05250	COG2200	EAL domain
I5M60_RS05255	COG4166	transmembrane transport
I5M60_RS05260	COG4174	ABC transporter (Permease)
I5M60_RS05265	COG4239	(ABC) transporter, permease
I5M60_RS05270	COG4172	Belongs to the ABC transporter superfamily
I5M60_RS05280	COG2814	Major facilitator Superfamily
I5M60_RS05285	COG1187	pseudouridine synthase activity
I5M60_RS05290	COG1061	Type III restriction enzyme res subunit
I5M60_RS05310	COG0494	nUDIX hydrolase
I5M60_RS05315	COG1349	DNA-binding transcription factor activity
I5M60_RS05340	COG0628	permease
I5M60_RS05355	COG0659	secondary active sulfate transmembrane transporter activity
I5M60_RS05360	COG2239	Acts as a magnesium transporter
I5M60_RS05365	COG4615	Cyclic peptide transporter
I5M60_RS05370	COG3145	DNA-N1-methyladenine dioxygenase activity
I5M60_RS05375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M60_RS05375	COG2169	Transcriptional regulator
I5M60_RS05390	COG0642	Histidine kinase
I5M60_RS05390	COG2198	Histidine kinase
I5M60_RS05400	COG0784	Response regulator, receiver
I5M60_RS05400	COG2205	protein histidine kinase activity
I5M60_RS05425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M60_RS05430	COG0584	glycerophosphoryl diester phosphodiesterase
I5M60_RS05435	COG2271	Major facilitator Superfamily
I5M60_RS05440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M60_RS05450	COG0247	lactate metabolic process
I5M60_RS05460	COG2271	Major facilitator Superfamily
I5M60_RS05470	COG1414	Transcriptional regulator
I5M60_RS05485	COG5464	transposase or invertase
I5M60_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
I5M60_RS05520	COG1169	isochorismate synthase
I5M60_RS05525	COG2153	protein acetylation
I5M60_RS05540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M60_RS05545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5M60_RS05555	COG0839	Belongs to the complex I subunit 6 family
I5M60_RS05600	COG0583	DNA-binding transcription factor activity
I5M60_RS05605	COG0436	Aminotransferase
I5M60_RS05615	COG0490	domain, Protein
I5M60_RS05615	COG0471	metal ion transport
I5M60_RS05620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M60_RS05640	COG0857	belongs to the CobB CobQ family
I5M60_RS05640	COG0280	phosphate acetyltransferase
I5M60_RS05645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5M60_RS05650	COG0622	Phosphoesterase
I5M60_RS05655	COG0625	glutathione transferase activity
I5M60_RS05660	COG0625	glutathione transferase activity
I5M60_RS05665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M60_RS05670	COG1090	epimerase
I5M60_RS05685	COG4598	ABC transporter
I5M60_RS05690	COG4160	amino acid transport
I5M60_RS05715	COG0163	prenyltransferase activity
I5M60_RS05720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5M60_RS05725	COG1286	toxin biosynthetic process
I5M60_RS05730	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I5M60_RS05735	COG0285	dihydrofolate synthase activity
I5M60_RS05745	COG0586	Pfam SNARE associated Golgi protein
I5M60_RS05755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M60_RS05775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M60_RS05790	COG3101	peptidyl-lysine hydroxylation
I5M60_RS05795	COG0730	response to heat
I5M60_RS05820	COG2062	phosphohistidine phosphatase, SixA
I5M60_RS05835	COG3691	Protein conserved in bacteria
I5M60_RS05845	COG2853	Lipoprotein
I5M60_RS05850	COG2116	formate transmembrane transporter activity
I5M60_RS05870	COG0583	DNA-binding transcription factor activity
I5M60_RS05875	COG0590	tRNA wobble adenosine to inosine editing
I5M60_RS05880	COG2807	transmembrane transport
I5M60_RS05890	COG0436	Aminotransferase
I5M60_RS05905	COG3275	phosphorelay sensor kinase activity
I5M60_RS05910	COG3279	Response regulator of the LytR AlgR family
I5M60_RS05925	COG3961	Belongs to the TPP enzyme family
I5M60_RS05930	COG0667	Aldo Keto reductase
I5M60_RS05945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M60_RS05950	COG2199	diguanylate cyclase activity
I5M60_RS05950	COG2200	EAL domain
I5M60_RS05965	COG3415	Transposase
I5M60_RS05970	COG3415	Transposase
I5M60_RS06000	COG0583	DNA-binding transcription factor activity
I5M60_RS06005	COG0385	Bile acid
I5M60_RS06010	COG3530	Putative quorum-sensing-regulated virulence factor
I5M60_RS06030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5M60_RS06065	COG4319	ketosteroid isomerase
I5M60_RS06075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5M60_RS06080	COG4208	sulfate ABC transporter
I5M60_RS06085	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I5M60_RS06090	COG4150	thiosulfate binding
I5M60_RS06100	COG2837	iron assimilation
I5M60_RS06120	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M60_RS06210	COG4810	utilization protein
I5M60_RS06220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M60_RS06225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M60_RS06230	COG5342	invasion associated locus B
I5M60_RS06240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M60_RS06240	COG0493	'glutamate synthase
I5M60_RS06245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M60_RS06255	COG1393	Belongs to the ArsC family
I5M60_RS06270	COG0400	carboxylic ester hydrolase activity
I5M60_RS06275	COG1444	tRNA N-acetyltransferase activity
I5M60_RS06280	COG2321	neutral zinc metallopeptidase
I5M60_RS06290	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5M60_RS06300	COG2716	regulation of RNA biosynthetic process
I5M60_RS06305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5M60_RS06310	COG0628	permease
I5M60_RS06320	COG4783	chaperone-mediated protein folding
I5M60_RS06325	COG1393	Belongs to the ArsC family
I5M60_RS06340	COG2233	PERMEase
I5M60_RS06350	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS06365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5M60_RS06380	COG2200	EAL domain
I5M60_RS06400	COG0641	radical SAM
I5M60_RS06405	COG3119	arylsulfatase activity
I5M60_RS06415	COG3179	chitinase
I5M60_RS06465	COG3617	BRO family, N-terminal domain
I5M60_RS06585	COG3728	DNA packaging
I5M60_RS06585	COG5484	DNA packaging
I5M60_RS06665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M60_RS06715	COG0516	GMP reductase activity
I5M60_RS06715	COG0517	IMP dehydrogenase activity
I5M60_RS06725	COG1645	bacterial-type flagellum-dependent swarming motility
I5M60_RS06745	COG2976	Protein conserved in bacteria
I5M60_RS06775	COG4953	penicillin-binding protein 1C
I5M60_RS06780	COG2373	Large extracellular alpha-helical protein
I5M60_RS06785	COG2897	thiosulfate sulfurtransferase activity
I5M60_RS06805	COG2975	iron-sulfur cluster assembly
I5M60_RS06810	COG0633	Ferredoxin
I5M60_RS06830	COG0822	iron-sulfur transferase activity
I5M60_RS06860	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M60_RS06865	COG3683	transport system, periplasmic component
I5M60_RS06870	COG3711	transcriptional antiterminator
I5M60_RS06875	COG2814	Major facilitator Superfamily
I5M60_RS06880	COG2017	converts alpha-aldose to the beta-anomer
I5M60_RS06885	COG0477	Major facilitator Superfamily
I5M60_RS06885	COG2814	Major facilitator Superfamily
I5M60_RS06890	COG0457	Tetratricopeptide repeat
I5M60_RS06895	COG1940	carbohydrate kinase activity
I5M60_RS06900	COG2259	Doxx family
I5M60_RS06910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M60_RS06910	COG1017	nitric oxide dioxygenase activity
I5M60_RS06915	COG0347	Belongs to the P(II) protein family
I5M60_RS06920	COG2204	response regulator
I5M60_RS06925	COG3170	Tfp pilus assembly protein FimV
I5M60_RS06930	COG2205	protein histidine kinase activity
I5M60_RS06935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5M60_RS06935	COG0047	phosphoribosylformylglycinamidine synthase activity
I5M60_RS06950	COG0560	Phosphoserine phosphatase
I5M60_RS06955	COG1737	Transcriptional regulator
I5M60_RS06960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M60_RS06970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5M60_RS06990	COG0681	Belongs to the peptidase S26 family
I5M60_RS07000	COG3086	response to oxidative stress
I5M60_RS07005	COG3026	antisigma factor binding
I5M60_RS07010	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I5M60_RS07025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I5M60_RS07035	COG0513	Belongs to the DEAD box helicase family
I5M60_RS07050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M60_RS07055	COG3118	belongs to the thioredoxin family
I5M60_RS07060	COG3148	PFAM DTW domain containing protein
I5M60_RS07070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M60_RS07075	COG5544	Lipoprotein
I5M60_RS07080	COG0477	Major facilitator Superfamily
I5M60_RS07105	COG0542	response to heat
I5M60_RS07120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M60_RS07125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M60_RS07135	COG1605	Chorismate mutase
I5M60_RS07135	COG0077	Prephenate dehydratase
I5M60_RS07145	COG1605	Chorismate mutase
I5M60_RS07145	COG0287	Prephenate dehydrogenase
I5M60_RS07150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M60_RS07160	COG2199	diguanylate cyclase activity
I5M60_RS07165	COG2885	chlorophyll binding
I5M60_RS07200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5M60_RS07205	COG4137	Cytochrome C assembly protein
I5M60_RS07210	COG4536	flavin adenine dinucleotide binding
I5M60_RS07225	COG0497	DNA recombination
I5M60_RS07240	COG2867	negative regulation of translational initiation
I5M60_RS07405	COG4695	Portal protein
I5M60_RS07450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5M60_RS07485	COG4974	Belongs to the 'phage' integrase family
I5M60_RS07510	COG2207	Transcriptional regulator
I5M60_RS07510	COG3708	Transcriptional regulator
I5M60_RS07515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS07550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS07560	COG0235	Class ii aldolase
I5M60_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS07585	COG2197	response regulator
I5M60_RS07590	COG3539	Fimbrial protein
I5M60_RS07600	COG3188	usher protein
I5M60_RS07620	COG3121	Chaperone
I5M60_RS07625	COG3539	Fimbrial protein
I5M60_RS07635	COG3284	Transcriptional regulator
I5M60_RS07640	COG0583	DNA-binding transcription factor activity
I5M60_RS07650	COG0640	Transcriptional regulator
I5M60_RS07655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M60_RS07670	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M60_RS07685	COG4575	ribosome binding
I5M60_RS07690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M60_RS07695	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M60_RS07700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M60_RS07710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5M60_RS07725	COG4176	ABC-type proline glycine betaine transport system permease component
I5M60_RS07735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5M60_RS07745	COG1846	Transcriptional regulator
I5M60_RS07750	COG1566	PFAM secretion protein HlyD family protein
I5M60_RS07755	COG2814	Major facilitator Superfamily
I5M60_RS07760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5M60_RS07780	COG1238	metal cluster binding
I5M60_RS07785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M60_RS07790	COG2823	Periplasmic or secreted lipoprotein
I5M60_RS07820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5M60_RS07840	COG1546	Belongs to the CinA family
I5M60_RS07850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M60_RS07855	COG1121	(ABC) transporter
I5M60_RS07860	COG2951	lytic endotransglycosylase activity
I5M60_RS07865	COG3730	PTS system glucitol sorbitol-specific
I5M60_RS07870	COG3732	PTS system glucitol sorbitol-specific
I5M60_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS07885	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS07890	COG1349	DNA-binding transcription factor activity
I5M60_RS07915	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M60_RS07920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I5M60_RS07925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M60_RS07930	COG1609	Transcriptional regulator
I5M60_RS07935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M60_RS07935	COG1263	PTS System
I5M60_RS07940	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS07950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I5M60_RS07960	COG3260	NADH ubiquinone oxidoreductase 20
I5M60_RS07965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M60_RS07970	COG3261	NADH dehydrogenase
I5M60_RS07970	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I5M60_RS07975	COG0650	Formate hydrogenlyase subunit 4
I5M60_RS07980	COG0651	ATP synthesis coupled electron transport
I5M60_RS07985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M60_RS08000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I5M60_RS08005	COG0298	carbon dioxide binding
I5M60_RS08010	COG0409	Hydrogenase expression formation protein
I5M60_RS08015	COG0309	Hydrogenase expression formation protein (HypE)
I5M60_RS08025	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS08035	COG4580	involved in the transport of maltose and maltodextrins
I5M60_RS08040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS08045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS08050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS08055	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M60_RS08060	COG1940	carbohydrate kinase activity
I5M60_RS08065	COG1609	Transcriptional regulator
I5M60_RS08070	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5M60_RS08075	COG1121	(ABC) transporter
I5M60_RS08080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M60_RS08085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M60_RS08100	COG0679	Auxin Efflux Carrier
I5M60_RS08120	COG3720	iron ion transport
I5M60_RS08125	COG4558	Periplasmic binding protein
I5M60_RS08130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS08170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M60_RS08175	COG0163	prenyltransferase activity
I5M60_RS08200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M60_RS08205	COG1388	LysM domain
I5M60_RS08205	COG4942	peptidase
I5M60_RS08265	COG2234	aminopeptidase activity
I5M60_RS08285	COG0720	synthase
I5M60_RS08290	COG0602	queuosine metabolic process
I5M60_RS08310	COG3956	TIGRFAM MazG family protein
I5M60_RS08315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M60_RS08325	COG2205	protein histidine kinase activity
I5M60_RS08325	COG4999	Histidine kinase
I5M60_RS08325	COG3437	response regulator, receiver
I5M60_RS08325	COG3850	Histidine kinase
I5M60_RS08330	COG1929	Belongs to the glycerate kinase type-1 family
I5M60_RS08335	COG4948	Mandelate Racemase Muconate Lactonizing
I5M60_RS08340	COG4948	Mandelate Racemase Muconate Lactonizing
I5M60_RS08345	COG2271	Major facilitator Superfamily
I5M60_RS08350	COG0716	FMN binding
I5M60_RS08355	COG0564	pseudouridine synthase activity
I5M60_RS08360	COG3098	single-species biofilm formation
I5M60_RS08375	COG1611	Belongs to the LOG family
I5M60_RS08380	COG0814	amino acid
I5M60_RS08385	COG1760	l-serine dehydratase
I5M60_RS08390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M60_RS08400	COG0477	Major facilitator Superfamily
I5M60_RS08405	COG1464	Belongs to the NlpA lipoprotein family
I5M60_RS08410	COG2011	ABC-type metal ion transport system permease component
I5M60_RS08415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5M60_RS08430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M60_RS08450	COG1454	alcohol dehydrogenase
I5M60_RS08455	COG0235	Class ii aldolase
I5M60_RS08460	COG0738	Major facilitator superfamily
I5M60_RS08480	COG1349	DNA-binding transcription factor activity
I5M60_RS08490	COG2363	Small membrane protein
I5M60_RS08495	COG0583	DNA-binding transcription factor activity
I5M60_RS08505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5M60_RS08510	COG2166	iron-sulfur cluster assembly
I5M60_RS08515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5M60_RS08520	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5M60_RS08685	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I5M60_RS08715	COG1454	alcohol dehydrogenase
I5M60_RS08715	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS08720	COG4656	Part of a membrane complex involved in electron transport
I5M60_RS08750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5M60_RS08755	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M60_RS08760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5M60_RS08760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5M60_RS08770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5M60_RS08775	COG1074	ATP-dependent DNA helicase activity
I5M60_RS08780	COG1025	Belongs to the peptidase M16 family
I5M60_RS08785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5M60_RS08790	COG4967	type IV pilus modification protein PilV
I5M60_RS08800	COG4795	General secretion pathway protein
I5M60_RS08805	COG2165	general secretion pathway protein
I5M60_RS08840	COG0861	Integral membrane protein TerC family
I5M60_RS08850	COG0667	Aldo Keto reductase
I5M60_RS08870	COG1609	Transcriptional regulator
I5M60_RS08880	COG2186	Transcriptional regulator
I5M60_RS08885	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS08890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS08895	COG1609	Transcriptional regulator
I5M60_RS08905	COG0583	DNA-binding transcription factor activity
I5M60_RS08910	COG1794	racemase activity, acting on amino acids and derivatives
I5M60_RS08915	COG1917	Cupin 2, conserved barrel domain protein
I5M60_RS08920	COG1175	transmembrane transport
I5M60_RS08925	COG0395	ABC-type sugar transport system, permease component
I5M60_RS08930	COG3842	ATPase activity
I5M60_RS08965	COG2814	Major facilitator Superfamily
I5M60_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS08975	COG0823	Involved in the tonB-independent uptake of proteins
I5M60_RS08985	COG0183	Belongs to the thiolase family
I5M60_RS09000	COG0814	amino acid
I5M60_RS09005	COG0667	Aldo Keto reductase
I5M60_RS09055	COG0697	spore germination
I5M60_RS09060	COG1846	Transcriptional regulator
I5M60_RS09065	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M60_RS09070	COG0582	viral genome integration into host DNA
I5M60_RS09075	COG4974	Belongs to the 'phage' integrase family
I5M60_RS09085	COG3539	Fimbrial protein
I5M60_RS09090	COG3121	Chaperone
I5M60_RS09095	COG3188	usher protein
I5M60_RS09100	COG3539	Fimbrial protein
I5M60_RS09105	COG3539	Fimbrial protein
I5M60_RS09110	COG3539	Fimbrial protein
I5M60_RS09120	COG2388	GCN5-related N-acetyl-transferase
I5M60_RS09125	COG3592	Divergent 4Fe-4S mono-cluster
I5M60_RS09140	COG1289	transmembrane transporter activity
I5M60_RS09145	COG1538	Outer membrane efflux protein
I5M60_RS09160	COG1393	Belongs to the ArsC family
I5M60_RS09165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M60_RS09200	COG0667	Aldo Keto reductase
I5M60_RS09215	COG2814	Major facilitator Superfamily
I5M60_RS09225	COG4942	peptidase
I5M60_RS09245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5M60_RS09255	COG4974	Belongs to the 'phage' integrase family
I5M60_RS09260	COG0716	FMN binding
I5M60_RS09270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5M60_RS09280	COG1272	protein, Hemolysin III
I5M60_RS09290	COG1737	Transcriptional regulator
I5M60_RS09295	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS09315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M60_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS09340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M60_RS09345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M60_RS09350	COG0006	proline dipeptidase activity
I5M60_RS09370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5M60_RS09375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M60_RS09390	COG2968	Membrane
I5M60_RS09400	COG0668	transmembrane transport
I5M60_RS09405	COG0191	fructose-bisphosphate aldolase activity
I5M60_RS09420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M60_RS09425	COG0501	Belongs to the peptidase M48B family
I5M60_RS09445	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I5M60_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS09480	COG1414	Transcriptional regulator
I5M60_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS09500	COG2146	nitrite reductase [NAD(P)H] activity
I5M60_RS09535	COG2814	Major facilitator Superfamily
I5M60_RS09545	COG2356	endonuclease I
I5M60_RS09550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5M60_RS09555	COG0189	ligase activity
I5M60_RS09575	COG2805	Type II/IV secretion system protein
I5M60_RS09580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5M60_RS09585	COG0762	integral membrane protein
I5M60_RS09600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M60_RS09610	COG3171	Protein conserved in bacteria
I5M60_RS09620	COG1194	a g-specific adenine glycosylase
I5M60_RS09635	COG2211	Major facilitator Superfamily
I5M60_RS09640	COG1982	Orn Lys Arg decarboxylase major
I5M60_RS09645	COG1811	Na channel or pump
I5M60_RS09655	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5M60_RS09720	COG3423	Transcriptional regulator
I5M60_RS09725	COG1278	Cold shock
I5M60_RS09735	COG3423	Transcriptional regulator
I5M60_RS09990	COG0626	cystathionine gamma-synthase activity
I5M60_RS09995	COG0583	DNA-binding transcription factor activity
I5M60_RS10015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M60_RS10020	COG0754	glutathionylspermidine amidase activity
I5M60_RS10035	COG0625	glutathione transferase activity
I5M60_RS10060	COG2211	Major facilitator Superfamily
I5M60_RS10065	COG0848	biopolymer transport protein
I5M60_RS10075	COG0626	cystathionine gamma-synthase activity
I5M60_RS10080	COG0586	Pfam SNARE associated Golgi protein
I5M60_RS10085	COG2207	Transcriptional regulator
I5M60_RS10090	COG1979	alcohol dehydrogenase
I5M60_RS10095	COG0656	L-ascorbic acid biosynthetic process
I5M60_RS10105	COG1032	radical SAM domain protein
I5M60_RS10110	COG2132	Multicopper oxidase
I5M60_RS10115	COG0204	Acyl-transferase
I5M60_RS10120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5M60_RS10125	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I5M60_RS10130	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M60_RS10140	COG0642	Histidine kinase
I5M60_RS10145	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M60_RS10150	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I5M60_RS10160	COG3150	esterase
I5M60_RS10165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M60_RS10170	COG3151	Protein conserved in bacteria
I5M60_RS10175	COG0494	nUDIX hydrolase
I5M60_RS10190	COG0754	glutathionylspermidine amidase activity
I5M60_RS10195	COG3384	dioxygenase
I5M60_RS10210	COG2960	long-chain fatty acid transporting porin activity
I5M60_RS10235	COG3025	triphosphatase activity
I5M60_RS10240	COG4991	sh3 domain protein
I5M60_RS10255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M60_RS10320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5M60_RS10325	COG0358	DNA primase activity
I5M60_RS10330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M60_RS10355	COG2197	response regulator
I5M60_RS10360	COG2198	Histidine kinase
I5M60_RS10360	COG2205	protein histidine kinase activity
I5M60_RS10360	COG0784	Response regulator, receiver
I5M60_RS10360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS10370	COG3247	response to pH
I5M60_RS10440	COG2376	Dihydroxyacetone kinase
I5M60_RS10445	COG1461	Dihydroxyacetone kinase
I5M60_RS10460	COG2375	cellular response to nickel ion
I5M60_RS10465	COG1695	Transcriptional regulator
I5M60_RS10515	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5M60_RS10515	COG1902	pentaerythritol trinitrate reductase activity
I5M60_RS10535	COG1451	nucleotide metabolic process
I5M60_RS10540	COG0673	inositol 2-dehydrogenase activity
I5M60_RS10545	COG0861	Integral membrane protein TerC family
I5M60_RS10560	COG2721	sulfolactate sulfo-lyase activity
I5M60_RS10570	COG2271	Major facilitator Superfamily
I5M60_RS10575	COG2186	Transcriptional regulator
I5M60_RS10580	COG0586	Pfam SNARE associated Golgi protein
I5M60_RS10590	COG1422	Protein of unknown function (DUF1090)
I5M60_RS10595	COG4575	ribosome binding
I5M60_RS10600	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I5M60_RS10610	COG2259	Doxx family
I5M60_RS10615	COG0435	Glutathione S-transferase
I5M60_RS10620	COG3152	Membrane
I5M60_RS10625	COG0583	DNA-binding transcription factor activity
I5M60_RS10630	COG1741	Belongs to the pirin family
I5M60_RS10655	COG1929	Belongs to the glycerate kinase type-1 family
I5M60_RS10660	COG2084	Dehydrogenase
I5M60_RS10670	COG2271	Major facilitator Superfamily
I5M60_RS10675	COG2721	sulfolactate sulfo-lyase activity
I5M60_RS10680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS10685	COG1349	DNA-binding transcription factor activity
I5M60_RS10695	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M60_RS10700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M60_RS10700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS10700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M60_RS10705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS10705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS10715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS10720	COG3414	Phosphotransferase system galactitol-specific IIB component
I5M60_RS10725	COG3775	system Galactitol-specific IIC component
I5M60_RS10730	COG1063	alcohol dehydrogenase
I5M60_RS10745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5M60_RS10765	COG2823	Periplasmic or secreted lipoprotein
I5M60_RS10770	COG0701	Predicted permease
I5M60_RS10775	COG0702	epimerase
I5M60_RS10780	COG0693	protein deglycase activity
I5M60_RS10795	COG3153	acetyltransferase
I5M60_RS10800	COG3154	lipid carrier protein
I5M60_RS10805	COG0826	peptidase U32
I5M60_RS10810	COG0826	peptidase U32
I5M60_RS10815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M60_RS10820	COG0814	amino acid
I5M60_RS10865	COG0195	Participates in both transcription termination and antitermination
I5M60_RS10905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5M60_RS10915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5M60_RS10920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5M60_RS10930	COG1534	Rna-binding protein
I5M60_RS10940	COG2027	D-alanyl-D-alanine carboxypeptidase
I5M60_RS10950	COG0697	spore germination
I5M60_RS10965	COG0142	geranyltranstransferase activity
I5M60_RS10970	COG3423	Transcriptional regulator
I5M60_RS10980	COG5007	Belongs to the BolA IbaG family
I5M60_RS10985	COG3113	response to antibiotic
I5M60_RS10990	COG2854	intermembrane phospholipid transfer
I5M60_RS10995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M60_RS11000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5M60_RS11005	COG1127	ABC transporter
I5M60_RS11010	COG0530	calcium, potassium:sodium antiporter activity
I5M60_RS11020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5M60_RS11025	COG3117	lipopolysaccharide transmembrane transporter activity
I5M60_RS11030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5M60_RS11035	COG1137	ATPase activity
I5M60_RS11040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5M60_RS11045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M60_RS11050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS11060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS11065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M60_RS11070	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5M60_RS11075	COG5002	protein histidine kinase activity
I5M60_RS11075	COG2198	Histidine kinase
I5M60_RS11075	COG0784	Response regulator, receiver
I5M60_RS11080	COG1312	Catalyzes the dehydration of D-mannonate
I5M60_RS11085	COG1063	alcohol dehydrogenase
I5M60_RS11090	COG2271	Major facilitator Superfamily
I5M60_RS11095	COG1242	4 iron, 4 sulfur cluster binding
I5M60_RS11100	COG0070	glutamate synthase
I5M60_RS11100	COG0069	glutamate synthase activity
I5M60_RS11100	COG0067	glutamate synthase
I5M60_RS11105	COG0493	'glutamate synthase
I5M60_RS11115	COG2969	positive regulation of protein catabolic process
I5M60_RS11120	COG0625	glutathione transferase activity
I5M60_RS11140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M60_RS11145	COG3105	Protein conserved in bacteria
I5M60_RS11150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M60_RS11155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M60_RS11180	COG2732	(Barnase) inhibitor
I5M60_RS11185	COG1289	transmembrane transporter activity
I5M60_RS11200	COG0583	DNA-binding transcription factor activity
I5M60_RS11205	COG0312	modulator of DNA gyrase
I5M60_RS11210	COG3164	Protein of unknown function
I5M60_RS11215	COG1530	ribonuclease E activity
I5M60_RS11225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5M60_RS11230	COG1792	Involved in formation and maintenance of cell shape
I5M60_RS11235	COG1077	Cell shape determining protein MreB Mrl
I5M60_RS11240	COG2200	EAL domain
I5M60_RS11240	COG2199	diguanylate cyclase activity
I5M60_RS11265	COG0511	ligase activity, forming carbon-carbon bonds
I5M60_RS11270	COG0439	Biotin carboxylase
I5M60_RS11275	COG3924	membrane
I5M60_RS11280	COG4145	pantothenate transmembrane transporter activity
I5M60_RS11305	COG4626	Terminase
I5M60_RS11305	COG1802	Transcriptional regulator
I5M60_RS11390	COG3561	AntA/AntB antirepressor
I5M60_RS11405	COG0582	viral genome integration into host DNA
I5M60_RS11410	COG1309	transcriptional regulator
I5M60_RS11415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS11420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M60_RS11455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M60_RS11475	COG0551	DNA topoisomerase type I activity
I5M60_RS11485	COG0758	DNA mediated transformation
I5M60_RS11515	COG3036	rescue of stalled ribosome
I5M60_RS11520	COG0789	Transcriptional regulator
I5M60_RS11535	COG0202	RNA polymerase activity
I5M60_RS11560	COG0201	protein transport
I5M60_RS11625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5M60_RS11640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5M60_RS11665	COG0051	transcription antitermination factor activity, RNA binding
I5M60_RS11720	COG2964	Protein conserved in bacteria
I5M60_RS11725	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M60_RS11735	COG1047	Peptidyl-prolyl cis-trans
I5M60_RS11740	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5M60_RS11755	COG0488	(ABC) transporter
I5M60_RS11760	COG0429	hydrolase of the alpha beta-hydrolase fold
I5M60_RS11770	COG3954	Phosphoribulokinase
I5M60_RS11775	COG1765	OsmC-like protein
I5M60_RS11785	COG1289	transmembrane transporter activity
I5M60_RS11790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M60_RS11815	COG0738	Major facilitator superfamily
I5M60_RS11820	COG0402	S-adenosylhomocysteine deaminase activity
I5M60_RS11825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M60_RS11850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M60_RS11855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I5M60_RS11860	COG3266	domain, Protein
I5M60_RS11875	COG4796	Type ii and iii secretion system protein
I5M60_RS11900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I5M60_RS11905	COG0494	nUDIX hydrolase
I5M60_RS11915	COG1011	Hydrolase
I5M60_RS11920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5M60_RS11945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M60_RS11950	COG2183	response to ionizing radiation
I5M60_RS11955	COG1918	ferrous iron import across plasma membrane
I5M60_RS11980	COG1040	competence protein
I5M60_RS11990	COG2610	gluconate transmembrane transporter activity
I5M60_RS11995	COG1640	4-alpha-glucanotransferase
I5M60_RS12000	COG0058	SHG alpha-glucan phosphorylase activity
I5M60_RS12010	COG1349	DNA-binding transcription factor activity
I5M60_RS12025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M60_RS12040	COG0058	SHG alpha-glucan phosphorylase activity
I5M60_RS12065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M60_RS12075	COG2610	gluconate transmembrane transporter activity
I5M60_RS12080	COG3265	gluconokinase activity
I5M60_RS12085	COG1609	Transcriptional regulator
I5M60_RS12090	COG1741	Belongs to the pirin family
I5M60_RS12095	COG0673	inositol 2-dehydrogenase activity
I5M60_RS12105	COG1247	-acetyltransferase
I5M60_RS12110	COG0405	Gamma-glutamyltransferase
I5M60_RS12120	COG0584	glycerophosphoryl diester phosphodiesterase
I5M60_RS12170	COG0559	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS12175	COG0683	leucine binding
I5M60_RS12185	COG0683	leucine binding
I5M60_RS12195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M60_RS12210	COG2177	Part of the ABC transporter FtsEX involved in
I5M60_RS12215	COG2884	Cell division ATP-binding protein ftsE
I5M60_RS12220	COG0552	protein localization to endoplasmic reticulum
I5M60_RS12225	COG0742	ribosomal rna small subunit methyltransferase
I5M60_RS12230	COG3776	membrane
I5M60_RS12240	COG3714	YhhN family
I5M60_RS12255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5M60_RS12265	COG0477	Major facilitator Superfamily
I5M60_RS12270	COG0628	permease
I5M60_RS12310	COG3479	Phenolic acid decarboxylase
I5M60_RS12320	COG0747	negative chemotaxis
I5M60_RS12325	COG0601	transmembrane transport
I5M60_RS12330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M60_RS12340	COG1124	(ABC) transporter
I5M60_RS12350	COG2239	Acts as a magnesium transporter
I5M60_RS12355	COG2081	HI0933 family
I5M60_RS12360	COG0306	phosphate transporter
I5M60_RS12370	COG0589	response to stress
I5M60_RS12390	COG0671	phosphoesterase, PA-phosphatase related
I5M60_RS12395	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5M60_RS12400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M60_RS12410	COG1454	alcohol dehydrogenase
I5M60_RS12420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M60_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS12430	COG0583	DNA-binding transcription factor activity
I5M60_RS12435	COG1295	ribonuclease BN
I5M60_RS12440	COG0477	Major facilitator Superfamily
I5M60_RS12445	COG2982	Protein involved in outer membrane biogenesis
I5M60_RS12455	COG0612	Peptidase, M16
I5M60_RS12465	COG2200	EAL domain
I5M60_RS12465	COG2199	diguanylate cyclase activity
I5M60_RS12470	COG0457	Tetratricopeptide repeat
I5M60_RS12470	COG3118	belongs to the thioredoxin family
I5M60_RS12475	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I5M60_RS12480	COG1215	transferase activity, transferring glycosyl groups
I5M60_RS12510	COG2194	sulfuric ester hydrolase activity
I5M60_RS12525	COG0457	Tetratricopeptide repeat
I5M60_RS12530	COG1215	transferase activity, transferring glycosyl groups
I5M60_RS12555	COG4608	Belongs to the ABC transporter superfamily
I5M60_RS12560	COG0444	Belongs to the ABC transporter superfamily
I5M60_RS12565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M60_RS12570	COG0601	transmembrane transport
I5M60_RS12575	COG0747	negative chemotaxis
I5M60_RS12605	COG2223	nitrite transmembrane transporter activity
I5M60_RS12610	COG5571	outer membrane autotransporter
I5M60_RS12615	COG2818	Glycosylase
I5M60_RS12620	COG0456	acetyltransferase
I5M60_RS12625	COG0243	molybdopterin cofactor binding
I5M60_RS12630	COG2885	chlorophyll binding
I5M60_RS12635	COG1609	Transcriptional regulator
I5M60_RS12645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS12665	COG2814	Major facilitator Superfamily
I5M60_RS12670	COG2944	sequence-specific DNA binding
I5M60_RS12675	COG1278	Cold shock
I5M60_RS12705	COG3274	enterobacterial common antigen metabolic process
I5M60_RS12710	COG4682	membrane
I5M60_RS12715	COG4682	membrane
I5M60_RS12730	COG4213	ABC transporter substrate-binding protein
I5M60_RS12740	COG4214	carbohydrate transport
I5M60_RS12745	COG2207	Transcriptional regulator
I5M60_RS12745	COG1609	Transcriptional regulator
I5M60_RS12750	COG2992	FlgJ-related protein
I5M60_RS12755	COG0366	Alpha amylase catalytic
I5M60_RS12760	COG3977	Valine--pyruvate aminotransferase
I5M60_RS12765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M60_RS12770	COG1414	Transcriptional regulator
I5M60_RS12775	COG3276	selenocysteine insertion sequence binding
I5M60_RS12785	COG0625	glutathione transferase activity
I5M60_RS12790	COG1566	PFAM secretion protein HlyD family protein
I5M60_RS12810	COG3722	fumarate hydratase activity
I5M60_RS12830	COG2186	Transcriptional regulator
I5M60_RS12840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5M60_RS12860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M60_RS12865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M60_RS12875	COG4942	peptidase
I5M60_RS12880	COG2861	carbohydrate metabolic process
I5M60_RS12885	COG0463	Glycosyl transferase, family 2
I5M60_RS12895	COG0156	8-amino-7-oxononanoate synthase activity
I5M60_RS12910	COG0859	PFAM glycosyl transferase family 9
I5M60_RS12935	COG0859	PFAM glycosyl transferase family 9
I5M60_RS12945	COG0438	transferase activity, transferring glycosyl groups
I5M60_RS12950	COG1216	Glycosyl transferase, family 2
I5M60_RS12955	COG1519	Transferase
I5M60_RS12990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5M60_RS13015	COG0842	Transport permease protein
I5M60_RS13020	COG1131	(ABC) transporter
I5M60_RS13040	COG1561	YicC-like family, N-terminal region
I5M60_RS13045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5M60_RS13050	COG2169	Transcriptional regulator
I5M60_RS13050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M60_RS13060	COG2860	membrane
I5M60_RS13080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M60_RS13085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M60_RS13090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5M60_RS13095	COG1494	fructose-1,6-bisphosphatase
I5M60_RS13105	COG3152	Membrane
I5M60_RS13130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5M60_RS13150	COG0786	glutamate:sodium symporter activity
I5M60_RS13155	COG2233	PERMEase
I5M60_RS13160	COG2982	Protein involved in outer membrane biogenesis
I5M60_RS13165	COG1263	PTS System
I5M60_RS13165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M60_RS13170	COG1486	melibiose metabolic process
I5M60_RS13180	COG1501	Belongs to the glycosyl hydrolase 31 family
I5M60_RS13185	COG2211	Major facilitator Superfamily
I5M60_RS13215	COG1064	alcohol dehydrogenase
I5M60_RS13225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5M60_RS13240	COG1464	Belongs to the NlpA lipoprotein family
I5M60_RS13265	COG0583	DNA-binding transcription factor activity
I5M60_RS13300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M60_RS13310	COG2814	Major facilitator Superfamily
I5M60_RS13320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M60_RS13320	COG1263	PTS System
I5M60_RS13325	COG0697	spore germination
I5M60_RS13340	COG2828	Protein conserved in bacteria
I5M60_RS13345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5M60_RS13350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5M60_RS13355	COG0583	DNA-binding transcription factor activity
I5M60_RS13360	COG3384	dioxygenase
I5M60_RS13370	COG1609	Transcriptional regulator
I5M60_RS13380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS13380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS13385	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M60_RS13390	COG4580	involved in the transport of maltose and maltodextrins
I5M60_RS13415	COG2188	Transcriptional regulator
I5M60_RS13455	COG2271	Major facilitator Superfamily
I5M60_RS13465	COG2197	response regulator
I5M60_RS13470	COG0440	acetolactate synthase activity
I5M60_RS13475	COG0028	Belongs to the TPP enzyme family
I5M60_RS13505	COG2814	Major facilitator Superfamily
I5M60_RS13510	COG0583	DNA-binding transcription factor activity
I5M60_RS13520	COG2610	gluconate transmembrane transporter activity
I5M60_RS13540	COG2149	membrane
I5M60_RS13555	COG2188	Transcriptional regulator
I5M60_RS13565	COG3645	SOS response
I5M60_RS13580	COG5645	(Lipo)protein
I5M60_RS13585	COG0823	Involved in the tonB-independent uptake of proteins
I5M60_RS13590	COG2271	Major facilitator Superfamily
I5M60_RS13600	COG0800	Aldolase
I5M60_RS13605	COG3734	2-keto-3-deoxy-galactonokinase
I5M60_RS13610	COG2186	Transcriptional regulator
I5M60_RS13625	COG0561	phosphatase activity
I5M60_RS13630	COG0187	DNA topoisomerase II activity
I5M60_RS13660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5M60_RS13690	COG2091	lysine biosynthetic process via aminoadipic acid
I5M60_RS13695	COG0431	NADPH-dependent FMN reductase
I5M60_RS13700	COG2252	PERMEase
I5M60_RS13705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M60_RS13710	COG0363	glucosamine-6-phosphate deaminase activity
I5M60_RS13715	COG2382	esterase
I5M60_RS13725	COG0704	Plays a role in the regulation of phosphate uptake
I5M60_RS13730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5M60_RS13735	COG0581	inorganic phosphate transmembrane transporter activity
I5M60_RS13740	COG0573	inorganic phosphate transmembrane transporter activity
I5M60_RS13745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5M60_RS13750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M60_RS13800	COG3312	ion transport
I5M60_RS13815	COG0716	FMN binding
I5M60_RS13820	COG1522	sequence-specific DNA binding
I5M60_RS13850	COG1129	ABC transporter
I5M60_RS13855	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS13865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS13870	COG1609	Transcriptional regulator
I5M60_RS13875	COG0477	Major facilitator Superfamily
I5M60_RS13880	COG2186	Transcriptional regulator
I5M60_RS13905	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5M60_RS13915	COG3084	Protein conserved in bacteria
I5M60_RS13920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5M60_RS13930	COG0204	Acyl-transferase
I5M60_RS13950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M60_RS13965	COG3852	Histidine kinase
I5M60_RS13980	COG1011	Hydrolase
I5M60_RS13995	COG0456	acetyltransferase
I5M60_RS14000	COG0657	acetylesterase activity
I5M60_RS14005	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5M60_RS14020	COG2864	formate dehydrogenase
I5M60_RS14025	COG0437	4 iron, 4 sulfur cluster binding
I5M60_RS14045	COG0205	6-phosphofructokinase activity
I5M60_RS14105	COG2211	Major facilitator Superfamily
I5M60_RS14115	COG1454	alcohol dehydrogenase
I5M60_RS14120	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS14125	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS14130	COG1129	ABC transporter
I5M60_RS14170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5M60_RS14175	COG2258	MOSC domain
I5M60_RS14180	COG2205	protein histidine kinase activity
I5M60_RS14185	COG0745	RESPONSE REGULATOR receiver
I5M60_RS14190	COG3678	ATP-independent chaperone mediated protein folding
I5M60_RS14210	COG1575	Belongs to the MenA family. Type 1 subfamily
I5M60_RS14225	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M60_RS14230	COG1609	Transcriptional regulator
I5M60_RS14235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5M60_RS14250	COG0626	cystathionine gamma-synthase activity
I5M60_RS14255	COG0527	aspartate kinase activity
I5M60_RS14255	COG0460	homoserine dehydrogenase
I5M60_RS14265	COG0737	Belongs to the 5'-nucleotidase family
I5M60_RS14275	COG0583	DNA-binding transcription factor activity
I5M60_RS14285	COG0697	spore germination
I5M60_RS14290	COG0371	Dehydrogenase
I5M60_RS14300	COG2207	Transcriptional regulator
I5M60_RS14305	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5M60_RS14320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5M60_RS14335	COG0583	DNA-binding transcription factor activity
I5M60_RS14410	COG3085	chromosome segregation
I5M60_RS14430	COG3978	acetolactate synthase activity
I5M60_RS14445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M60_RS14450	COG0583	DNA-binding transcription factor activity
I5M60_RS14460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M60_RS14465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M60_RS14475	COG1811	Na channel or pump
I5M60_RS14500	COG3118	belongs to the thioredoxin family
I5M60_RS14505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5M60_RS14510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5M60_RS14520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5M60_RS14525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5M60_RS14530	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M60_RS14535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I5M60_RS14540	COG0456	acetyltransferase
I5M60_RS14545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5M60_RS14550	COG2244	polysaccharide biosynthetic process
I5M60_RS14595	COG3071	HemY protein
I5M60_RS14600	COG2959	enzyme of heme biosynthesis
I5M60_RS14615	COG3072	Adenylate cyclase
I5M60_RS14645	COG1011	Hydrolase
I5M60_RS14650	COG0210	DNA helicase
I5M60_RS14680	COG1280	lysine exporter protein (LysE YggA)
I5M60_RS14690	COG1280	lysine exporter protein (LysE YggA)
I5M60_RS14695	COG2267	carboxylic ester hydrolase activity
I5M60_RS14700	COG0561	phosphatase activity
I5M60_RS14705	COG0697	spore germination
I5M60_RS14710	COG0583	DNA-binding transcription factor activity
I5M60_RS14740	COG3165	ubiquinone biosynthetic process from chorismate
I5M60_RS14760	COG0805	protein transport
I5M60_RS14800	COG1739	Uncharacterized protein family UPF0029
I5M60_RS14810	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I5M60_RS14840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5M60_RS14885	COG0250	Participates in transcription elongation, termination and antitermination
I5M60_RS14920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M60_RS14925	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M60_RS14935	COG3706	GGDEF domain
I5M60_RS14950	COG2104	thiamine diphosphate biosynthetic process
I5M60_RS14955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M60_RS14970	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I5M60_RS15005	COG3678	ATP-independent chaperone mediated protein folding
I5M60_RS15010	COG4191	Histidine kinase
I5M60_RS15020	COG0151	Belongs to the GarS family
I5M60_RS15050	COG0456	acetyltransferase
I5M60_RS15060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5M60_RS15090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M60_RS15145	COG0527	aspartate kinase activity
I5M60_RS15155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5M60_RS15165	COG0251	oxidation-reduction process
I5M60_RS15235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5M60_RS15245	COG0534	Mate efflux family protein
I5M60_RS15255	COG3237	CsbD-like
I5M60_RS15260	COG0735	belongs to the Fur family
I5M60_RS15270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M60_RS15285	COG0305	Participates in initiation and elongation during chromosome replication
I5M60_RS15290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5M60_RS15305	COG0432	Pfam Uncharacterised protein family UPF0047
I5M60_RS15310	COG2315	Protein conserved in bacteria
I5M60_RS15325	COG0741	lytic transglycosylase activity
I5M60_RS15330	COG4771	TonB-dependent receptor
I5M60_RS15350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M60_RS15360	COG0483	inositol monophosphate 1-phosphatase activity
I5M60_RS15365	COG1609	Transcriptional regulator
I5M60_RS15370	COG1234	tRNA 3'-trailer cleavage
I5M60_RS15400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M60_RS15410	COG0789	Transcriptional regulator
I5M60_RS15415	COG0625	glutathione transferase activity
I5M60_RS15420	COG2252	PERMEase
I5M60_RS15425	COG0025	NhaP-type Na H and K H
I5M60_RS15430	COG0583	DNA-binding transcription factor activity
I5M60_RS15435	COG1380	Effector of murein hydrolase LrgA
I5M60_RS15440	COG1346	cytolysis
I5M60_RS15445	COG3539	Fimbrial protein
I5M60_RS15475	COG3162	membrane
I5M60_RS15480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5M60_RS15490	COG1301	dicarboxylic acid transport
I5M60_RS15495	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5M60_RS15530	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS15535	COG1129	ABC transporter
I5M60_RS15540	COG0784	Response regulator, receiver
I5M60_RS15540	COG4191	Histidine kinase
I5M60_RS15550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5M60_RS15560	COG3454	Phosphonate metabolism
I5M60_RS15565	COG4778	phosphonate C-P lyase system protein PhnL
I5M60_RS15570	COG4107	phosphonate C-P lyase system protein PhnK
I5M60_RS15575	COG3627	carbon phosphorus lyase activity
I5M60_RS15580	COG3626	phosphonate metabolism
I5M60_RS15585	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I5M60_RS15590	COG3624	Phosphonate C-P lyase system protein PhnG
I5M60_RS15595	COG2188	Transcriptional regulator
I5M60_RS15600	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I5M60_RS15605	COG2824	Alkylphosphonate utilization operon protein PhnA
I5M60_RS15615	COG2169	Transcriptional regulator
I5M60_RS15620	COG1486	melibiose metabolic process
I5M60_RS15665	COG0861	Integral membrane protein TerC family
I5M60_RS15680	COG1215	transferase activity, transferring glycosyl groups
I5M60_RS15685	COG1649	PFAM Uncharacterised BCR, COG1649
I5M60_RS15685	COG0726	polysaccharide deacetylase
I5M60_RS15690	COG0457	Tetratricopeptide repeat
I5M60_RS15720	COG1309	transcriptional regulator
I5M60_RS15735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M60_RS15740	COG1027	Aspartate ammonia-lyase
I5M60_RS15745	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5M60_RS15750	COG0531	amino acid
I5M60_RS15820	COG1509	lysine 2,3-aminomutase activity
I5M60_RS15835	COG5510	response to toxic substance
I5M60_RS15840	COG2076	Multidrug Resistance protein
I5M60_RS15860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M60_RS15865	COG1053	succinate dehydrogenase
I5M60_RS15880	COG3264	Mechanosensitive ion channel
I5M60_RS15880	COG1511	domain protein
I5M60_RS15900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS15920	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5M60_RS15925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5M60_RS15925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5M60_RS15930	COG0802	atpase or kinase
I5M60_RS15935	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M60_RS15955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5M60_RS15960	COG0330	HflC and HflK could
I5M60_RS15965	COG0330	HflC and HflK could
I5M60_RS15975	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I5M60_RS15990	COG0557	exoribonuclease II activity
I5M60_RS15995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M60_RS16000	COG1960	acyl-CoA dehydrogenase activity
I5M60_RS16010	COG3650	response to hydrogen peroxide
I5M60_RS16015	COG1073	alpha beta
I5M60_RS16075	COG2965	DNA replication, synthesis of RNA primer
I5M60_RS16080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5M60_RS16090	COG3061	Opacity-associated protein A
I5M60_RS16095	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M60_RS16100	COG1113	amino acid transport
I5M60_RS16110	COG0697	spore germination
I5M60_RS16120	COG0702	epimerase
I5M60_RS16125	COG1733	regulation of RNA biosynthetic process
I5M60_RS16140	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I5M60_RS16155	COG1253	flavin adenine dinucleotide binding
I5M60_RS16165	COG0729	surface antigen
I5M60_RS16170	COG2911	Protein conserved in bacteria
I5M60_RS16175	COG2105	PFAM AIG2 family protein
I5M60_RS16195	COG1879	ABC-type sugar transport system periplasmic component
I5M60_RS16200	COG1129	ABC transporter
I5M60_RS16205	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS16210	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS16220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5M60_RS16245	COG0312	modulator of DNA gyrase
I5M60_RS16285	COG3964	amidohydrolase
I5M60_RS16300	COG2706	6-phosphogluconolactonase activity
I5M60_RS16305	COG3711	transcriptional antiterminator
I5M60_RS16305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS16310	COG3077	Addiction module antitoxin, RelB DinJ family
I5M60_RS16315	COG2026	Addiction module toxin, RelE StbE family
I5M60_RS16320	COG0602	queuosine metabolic process
I5M60_RS16345	COG1486	melibiose metabolic process
I5M60_RS16350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS16355	COG0366	Alpha amylase catalytic
I5M60_RS16360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M60_RS16360	COG1263	PTS System
I5M60_RS16395	COG2731	YhcH YjgK YiaL family protein
I5M60_RS16400	COG2222	sugar isomerase
I5M60_RS16405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS16410	COG1228	amidohydrolase
I5M60_RS16415	COG1288	antiporter activity
I5M60_RS16420	COG2188	Transcriptional regulator
I5M60_RS16445	COG0525	valine-tRNA ligase activity
I5M60_RS16450	COG2927	DNA polymerase III (CHI subunit)
I5M60_RS16460	COG0795	lipopolysaccharide-transporting ATPase activity
I5M60_RS16465	COG0795	lipopolysaccharide-transporting ATPase activity
I5M60_RS16470	COG0433	COG0433 Predicted ATPase
I5M60_RS16485	COG3718	enzyme involved in inositol metabolism
I5M60_RS16490	COG1737	Transcriptional regulator
I5M60_RS16490	COG0837	glucose binding
I5M60_RS16495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS16500	COG3962	Belongs to the TPP enzyme family
I5M60_RS16510	COG1082	Xylose isomerase domain protein TIM barrel
I5M60_RS16520	COG1653	transport
I5M60_RS16525	COG3842	ATPase activity
I5M60_RS16530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M60_RS16535	COG0395	ABC-type sugar transport system, permease component
I5M60_RS16540	COG1175	transmembrane transport
I5M60_RS16545	COG1064	alcohol dehydrogenase
I5M60_RS16550	COG0659	secondary active sulfate transmembrane transporter activity
I5M60_RS16555	COG0288	reversible hydration of carbon dioxide
I5M60_RS16565	COG0582	viral genome integration into host DNA
I5M60_RS16670	COG3507	Belongs to the glycosyl hydrolase 43 family
I5M60_RS16675	COG2211	Major facilitator Superfamily
I5M60_RS16690	COG3272	Protein of unknown function (DUF1722)
I5M60_RS16710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M60_RS16725	COG0300	oxidoreductase activity
I5M60_RS16735	COG0789	Transcriptional regulator
I5M60_RS16740	COG3040	lipid binding
I5M60_RS16750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M60_RS16755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS16760	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS16765	COG1538	Outer membrane efflux protein
I5M60_RS16770	COG0745	RESPONSE REGULATOR receiver
I5M60_RS16775	COG5002	protein histidine kinase activity
I5M60_RS16790	COG2850	peptidyl-arginine hydroxylation
I5M60_RS16820	COG0842	Transport permease protein
I5M60_RS16825	COG1129	ABC transporter
I5M60_RS16825	COG0842	Transport permease protein
I5M60_RS16830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS16840	COG1879	ABC-type sugar transport system periplasmic component
I5M60_RS16845	COG1129	ABC transporter
I5M60_RS16850	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS16860	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M60_RS16865	COG0583	DNA-binding transcription factor activity
I5M60_RS16875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M60_RS16880	COG5457	Domain of unknown function (DUF1127)
I5M60_RS16890	COG1566	PFAM secretion protein HlyD family protein
I5M60_RS16905	COG1924	4 iron, 4 sulfur cluster binding
I5M60_RS16910	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I5M60_RS16925	COG2733	membrane
I5M60_RS16935	COG1917	Cupin 2, conserved barrel domain protein
I5M60_RS16935	COG2207	Transcriptional regulator
I5M60_RS16940	COG5464	transposase or invertase
I5M60_RS16945	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS16955	COG0523	cobalamin synthesis protein
I5M60_RS16960	COG2879	small protein
I5M60_RS16965	COG1966	Carbon starvation protein
I5M60_RS16980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M60_RS16985	COG2368	4-hydroxyphenylacetate
I5M60_RS17005	COG3971	2-oxopent-4-enoate hydratase activity
I5M60_RS17015	COG3384	dioxygenase
I5M60_RS17020	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS17030	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M60_RS17040	COG1846	Transcriptional regulator
I5M60_RS17070	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I5M60_RS17085	COG3734	2-keto-3-deoxy-galactonokinase
I5M60_RS17090	COG0800	Aldolase
I5M60_RS17095	COG1737	Transcriptional regulator
I5M60_RS17105	COG1214	PFAM Peptidase M22, glycoprotease
I5M60_RS17105	COG0456	acetyltransferase
I5M60_RS17110	COG2271	Major facilitator Superfamily
I5M60_RS17115	COG1802	Transcriptional regulator
I5M60_RS17120	COG1063	alcohol dehydrogenase
I5M60_RS17130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M60_RS17130	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5M60_RS17145	COG3715	PTS system
I5M60_RS17150	COG3716	PTS system mannose fructose sorbose family IID component
I5M60_RS17155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M60_RS17165	COG5464	transposase or invertase
I5M60_RS17180	COG1484	DNA-dependent DNA replication
I5M60_RS17195	COG2966	Psort location CytoplasmicMembrane, score
I5M60_RS17210	COG2197	response regulator
I5M60_RS17215	COG2197	response regulator
I5M60_RS17220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M60_RS17225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS17225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS17230	COG4114	ferric iron reductase
I5M60_RS17235	COG3706	GGDEF domain
I5M60_RS17270	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I5M60_RS17275	COG0456	acetyltransferase
I5M60_RS17280	COG1011	Hydrolase
I5M60_RS17290	COG2823	Periplasmic or secreted lipoprotein
I5M60_RS17300	COG4667	esterase of the alpha-beta hydrolase superfamily
I5M60_RS17305	COG0084	hydrolase, TatD family'
I5M60_RS17310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M60_RS17340	COG3726	membrane protein affecting hemolysin expression
I5M60_RS17345	COG0560	Phosphoserine phosphatase
I5M60_RS17350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5M60_RS17360	COG0488	(ABC) transporter
I5M60_RS17365	COG0741	lytic transglycosylase activity
I5M60_RS17385	COG3708	Transcriptional regulator
I5M60_RS17385	COG2207	Transcriptional regulator
I5M60_RS17390	COG3045	CreA protein
I5M60_RS17395	COG0745	RESPONSE REGULATOR receiver
I5M60_RS17400	COG2205	protein histidine kinase activity
I5M60_RS17405	COG4452	Inner membrane protein CreD
I5M60_RS17410	COG0745	RESPONSE REGULATOR receiver
I5M60_RS17420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I5M60_RS17430	COG0527	aspartate kinase activity
I5M60_RS17430	COG0460	homoserine dehydrogenase
I5M60_RS17440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5M60_RS17455	COG1115	amino acid carrier protein
I5M60_RS17460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M60_RS17465	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M60_RS17470	COG0477	Major facilitator Superfamily
I5M60_RS17475	COG1584	GPR1 FUN34 yaaH family protein
I5M60_RS17480	COG4735	regulation of single-species biofilm formation
I5M60_RS17505	COG0583	DNA-binding transcription factor activity
I5M60_RS17515	COG0196	riboflavin kinase activity
I5M60_RS17530	COG1047	Peptidyl-prolyl cis-trans
I5M60_RS17555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5M60_RS17620	COG0505	Belongs to the CarA family
I5M60_RS17665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M60_RS17675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5M60_RS17680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5M60_RS17695	COG3493	citrate carrier protein
I5M60_RS17705	COG0564	pseudouridine synthase activity
I5M60_RS17715	COG0417	DNA replication proofreading
I5M60_RS17720	COG0235	Class ii aldolase
I5M60_RS17740	COG0586	Pfam SNARE associated Golgi protein
I5M60_RS17750	COG1178	ABC-type Fe3 transport system permease component
I5M60_RS17770	COG2814	Major facilitator Superfamily
I5M60_RS17775	COG2271	Major facilitator Superfamily
I5M60_RS17780	COG0583	DNA-binding transcription factor activity
I5M60_RS17790	COG0738	Major facilitator superfamily
I5M60_RS17835	COG0028	Belongs to the TPP enzyme family
I5M60_RS17845	COG1609	Transcriptional regulator
I5M60_RS17865	COG0768	penicillin binding
I5M60_RS17870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5M60_RS17875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5M60_RS17890	COG0772	Belongs to the SEDS family
I5M60_RS17915	COG0849	cell division
I5M60_RS17920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5M60_RS17940	COG0494	nUDIX hydrolase
I5M60_RS17965	COG1459	type II secretion system
I5M60_RS17970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5M60_RS17975	COG4969	Belongs to the N-Me-Phe pilin family
I5M60_RS17985	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5M60_RS17990	COG3725	Membrane protein required for beta-lactamase induction
I5M60_RS17995	COG3940	Belongs to the glycosyl hydrolase 43 family
I5M60_RS18000	COG2211	Major facilitator Superfamily
I5M60_RS18005	COG1113	amino acid transport
I5M60_RS18010	COG2186	Transcriptional regulator
I5M60_RS18015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I5M60_RS18020	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M60_RS18025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M60_RS18040	COG3064	Membrane
I5M60_RS18090	COG2132	Multicopper oxidase
I5M60_RS18095	COG4993	Dehydrogenase
I5M60_RS18110	COG0288	reversible hydration of carbon dioxide
I5M60_RS18115	COG1131	(ABC) transporter
I5M60_RS18120	COG0842	Transport permease protein
I5M60_RS18125	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS18130	COG0726	polysaccharide deacetylase
I5M60_RS18150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5M60_RS18155	COG0617	tRNA 3'-terminal CCA addition
I5M60_RS18175	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5M60_RS18180	COG1643	Atp-dependent helicase
I5M60_RS18275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M60_RS18280	COG4774	siderophore transport
I5M60_RS18285	COG1120	ATPase activity
I5M60_RS18290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M60_RS18295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS18315	COG2860	membrane
I5M60_RS18335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M60_RS18340	COG3835	regulator
I5M60_RS18355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5M60_RS18360	COG0024	Methionine aminopeptidase
I5M60_RS18385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5M60_RS18395	COG0575	Belongs to the CDS family
I5M60_RS18400	COG0750	zinc metalloprotease
I5M60_RS18410	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I5M60_RS18450	COG1982	Orn Lys Arg decarboxylase major
I5M60_RS18455	COG0346	lactoylglutathione lyase activity
I5M60_RS18465	COG4568	rho-dependent transcription termination
I5M60_RS18480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I5M60_RS18485	COG3015	lipoprotein NlpE involved in copper resistance
I5M60_RS18490	COG0791	NLP P60 protein
I5M60_RS18500	COG1720	tRNA m6t6A37 methyltransferase activity
I5M60_RS18510	COG1464	Belongs to the NlpA lipoprotein family
I5M60_RS18515	COG2011	ABC-type metal ion transport system permease component
I5M60_RS18525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5M60_RS18560	COG0656	L-ascorbic acid biosynthetic process
I5M60_RS18565	COG0583	DNA-binding transcription factor activity
I5M60_RS18570	COG2814	Major facilitator Superfamily
I5M60_RS18580	COG2226	methyltransferase
I5M60_RS18585	COG0741	lytic transglycosylase activity
I5M60_RS18585	COG1388	LysM domain
I5M60_RS18595	COG2226	methyltransferase
I5M60_RS18605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M60_RS18615	COG0583	DNA-binding transcription factor activity
I5M60_RS18625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M60_RS18630	COG1960	acyl-CoA dehydrogenase activity
I5M60_RS18640	COG0121	glutamine amidotransferase
I5M60_RS18645	COG3034	peptidoglycan biosynthetic process
I5M60_RS18660	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M60_RS18665	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M60_RS18680	COG2991	Protein conserved in bacteria
I5M60_RS18695	COG0454	-acetyltransferase
I5M60_RS18700	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5M60_RS18720	COG1802	Transcriptional regulator
I5M60_RS18725	COG1113	amino acid transport
I5M60_RS18730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M60_RS18735	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS18740	COG0579	oxidoreductase
I5M60_RS18755	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5M60_RS18760	COG0625	glutathione transferase activity
I5M60_RS18765	COG3775	system Galactitol-specific IIC component
I5M60_RS18770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M60_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS18780	COG1070	Carbohydrate kinase
I5M60_RS18800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M60_RS18805	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M60_RS18810	COG0022	dehydrogenase e1 component
I5M60_RS18815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5M60_RS18875	COG1192	Involved in chromosome partitioning
I5M60_RS18880	COG0582	viral genome integration into host DNA
I5M60_RS18905	COG0791	NLP P60 protein
I5M60_RS18925	COG3639	organic phosphonate transmembrane transporter activity
I5M60_RS18935	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5M60_RS18960	COG3188	usher protein
I5M60_RS18975	COG0765	amino acid transport
I5M60_RS18980	COG0765	amino acid transport
I5M60_RS18985	COG1126	abc transporter atp-binding protein
I5M60_RS18990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS19030	COG4302	ethanolamine ammonia-lyase activity
I5M60_RS19035	COG4303	Ethanolamine ammonia lyase large subunit
I5M60_RS19050	COG0833	amino acid
I5M60_RS19055	COG2040	homocysteine
I5M60_RS19060	COG4521	taurine ABC transporter
I5M60_RS19065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5M60_RS19070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M60_RS19075	COG2175	clavaminate synthase activity
I5M60_RS19085	COG0113	porphobilinogen synthase activity
I5M60_RS19090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5M60_RS19095	COG1335	isochorismatase
I5M60_RS19100	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I5M60_RS19140	COG1785	Belongs to the alkaline phosphatase family
I5M60_RS19150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5M60_RS19160	COG3416	Protein conserved in bacteria
I5M60_RS19165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M60_RS19175	COG4126	flavin adenine dinucleotide binding
I5M60_RS19190	COG1940	carbohydrate kinase activity
I5M60_RS19195	COG0419	ATPase involved in DNA repair
I5M60_RS19200	COG0420	3'-5' exonuclease activity
I5M60_RS19225	COG0366	Alpha amylase catalytic
I5M60_RS19230	COG0583	DNA-binding transcription factor activity
I5M60_RS19235	COG1335	isochorismatase
I5M60_RS19245	COG1228	amidohydrolase
I5M60_RS19255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS19270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS19280	COG0450	alkyl hydroperoxide reductase
I5M60_RS19305	COG1862	Preprotein translocase
I5M60_RS19310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M60_RS19315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M60_RS19335	COG4238	major outer membrane lipoprotein
I5M60_RS19345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M60_RS19345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M60_RS19365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5M60_RS19370	COG0667	Aldo Keto reductase
I5M60_RS19380	COG0142	geranyltranstransferase activity
I5M60_RS19400	COG0693	protein deglycase activity
I5M60_RS19405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5M60_RS19415	COG2814	Major facilitator Superfamily
I5M60_RS19420	COG0673	inositol 2-dehydrogenase activity
I5M60_RS19435	COG1053	succinate dehydrogenase
I5M60_RS19445	COG1053	succinate dehydrogenase
I5M60_RS19450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M60_RS19455	COG1414	Transcriptional regulator
I5M60_RS19470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5M60_RS19475	COG1845	cytochrome c oxidase, subunit III
I5M60_RS19480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5M60_RS19485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5M60_RS19490	COG2223	nitrite transmembrane transporter activity
I5M60_RS19495	COG3056	Lipoprotein
I5M60_RS19500	COG0271	Belongs to the BolA IbaG family
I5M60_RS19520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5M60_RS19525	COG0776	regulation of translation
I5M60_RS19530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M60_RS19535	COG1555	photosystem II stabilization
I5M60_RS19540	COG0824	Thioesterase
I5M60_RS19550	COG4533	DNA binding
I5M60_RS19565	COG1522	sequence-specific DNA binding
I5M60_RS19570	COG1132	(ABC) transporter
I5M60_RS19575	COG1132	(ABC) transporter
I5M60_RS19580	COG0347	Belongs to the P(II) protein family
I5M60_RS19585	COG0004	ammonium transporteR
I5M60_RS19590	COG1946	Acyl-CoA thioesterase
I5M60_RS19595	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I5M60_RS19600	COG3695	enzyme binding
I5M60_RS19630	COG2364	Membrane
I5M60_RS19645	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M60_RS19655	COG2182	Extracellular solute-binding protein
I5M60_RS19660	COG1175	transmembrane transport
I5M60_RS19665	COG3833	ABC-type maltose transport systems, permease component
I5M60_RS19670	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I5M60_RS19675	COG1874	Beta-galactosidase
I5M60_RS19725	COG0110	maltose O-acetyltransferase activity
I5M60_RS19740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M60_RS19745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS19750	COG1309	transcriptional regulator
I5M60_RS19755	COG1196	nuclear chromosome segregation
I5M60_RS19755	COG3264	Mechanosensitive ion channel
I5M60_RS19760	COG5464	transposase or invertase
I5M60_RS19770	COG3923	Primosomal replication protein n
I5M60_RS19775	COG2832	Protein of unknown function (DUF454)
I5M60_RS19815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS19820	COG4651	solute:proton antiporter activity
I5M60_RS19820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5M60_RS19825	COG2223	nitrite transmembrane transporter activity
I5M60_RS19835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M60_RS19840	COG3735	TraB family
I5M60_RS19855	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5M60_RS19860	COG0330	HflC and HflK could
I5M60_RS19865	COG4619	ABC transporter
I5M60_RS19870	COG0390	transport system, permease component
I5M60_RS19875	COG3118	belongs to the thioredoxin family
I5M60_RS19880	COG0300	oxidoreductase activity
I5M60_RS19885	COG2755	lipolytic protein G-D-S-L family
I5M60_RS19890	COG4181	ATPase activity
I5M60_RS19895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5M60_RS19915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5M60_RS19920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5M60_RS19935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5M60_RS19945	COG2501	S4 domain
I5M60_RS19995	COG3539	Fimbrial protein
I5M60_RS20000	COG3121	Chaperone
I5M60_RS20005	COG3188	usher protein
I5M60_RS20020	COG1560	Kdo2-lipid A biosynthetic process
I5M60_RS20030	COG3710	Transcriptional regulator
I5M60_RS20035	COG0531	amino acid
I5M60_RS20040	COG1982	Orn Lys Arg decarboxylase major
I5M60_RS20045	COG3104	oligopeptide transport
I5M60_RS20075	COG0673	inositol 2-dehydrogenase activity
I5M60_RS20090	COG1129	ABC transporter
I5M60_RS20095	COG4211	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS20140	COG1566	PFAM secretion protein HlyD family protein
I5M60_RS20145	COG1120	ATPase activity
I5M60_RS20150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS20180	COG1473	amidohydrolase
I5M60_RS20185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS20190	COG0667	Aldo Keto reductase
I5M60_RS20195	COG4608	Belongs to the ABC transporter superfamily
I5M60_RS20200	COG0444	Belongs to the ABC transporter superfamily
I5M60_RS20205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M60_RS20210	COG0601	transmembrane transport
I5M60_RS20215	COG0747	negative chemotaxis
I5M60_RS20240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M60_RS20250	COG0668	transmembrane transport
I5M60_RS20255	COG0583	DNA-binding transcription factor activity
I5M60_RS20265	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS20275	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS20280	COG1129	ABC transporter
I5M60_RS20290	COG1879	ABC-type sugar transport system periplasmic component
I5M60_RS20295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5M60_RS20300	COG2390	Transcriptional regulator
I5M60_RS20305	COG3959	Transketolase, thiamine diphosphate binding domain
I5M60_RS20310	COG3958	Transketolase
I5M60_RS20315	COG2977	Belongs to the P-Pant transferase superfamily
I5M60_RS20320	COG4771	TonB-dependent receptor
I5M60_RS20325	COG2382	esterase
I5M60_RS20330	COG3251	PFAM MbtH domain protein
I5M60_RS20335	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I5M60_RS20335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5M60_RS20340	COG1120	ATPase activity
I5M60_RS20345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS20350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M60_RS20360	COG4592	Periplasmic binding protein
I5M60_RS20365	COG1169	isochorismate synthase
I5M60_RS20370	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5M60_RS20375	COG1535	isochorismatase
I5M60_RS20375	COG3433	isochorismatase activity
I5M60_RS20380	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS20390	COG1966	Carbon starvation protein
I5M60_RS20395	COG2879	small protein
I5M60_RS20410	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS20415	COG0371	Dehydrogenase
I5M60_RS20420	COG1129	ABC transporter
I5M60_RS20425	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS20455	COG2271	Major facilitator Superfamily
I5M60_RS20460	COG0483	inositol monophosphate 1-phosphatase activity
I5M60_RS20470	COG0402	S-adenosylhomocysteine deaminase activity
I5M60_RS20480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M60_RS20495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M60_RS20505	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS20510	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M60_RS20515	COG1129	ABC transporter
I5M60_RS20540	COG0436	Aminotransferase
I5M60_RS20545	COG1475	DNA binding
I5M60_RS20550	COG3969	phosphoadenosine phosphosulfate
I5M60_RS20555	COG0583	DNA-binding transcription factor activity
I5M60_RS20560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M60_RS20580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M60_RS20585	COG3719	Belongs to the RNase T2 family
I5M60_RS20590	COG3069	C4-dicarboxylate transmembrane transporter activity
I5M60_RS20610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M60_RS20625	COG0583	DNA-binding transcription factor activity
I5M60_RS20640	COG1686	Belongs to the peptidase S11 family
I5M60_RS20645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M60_RS20650	COG0772	Belongs to the SEDS family
I5M60_RS20655	COG0768	penicillin binding
I5M60_RS20665	COG0799	negative regulation of ribosome biogenesis
I5M60_RS20680	COG1466	dna polymerase III delta subunit
I5M60_RS20695	COG2888	peptidyl-tyrosine sulfation
I5M60_RS20710	COG1126	abc transporter atp-binding protein
I5M60_RS20715	COG0765	amino acid transport
I5M60_RS20720	COG0765	amino acid transport
I5M60_RS20735	COG4535	Mg2 and Co2 transporter CorC
I5M60_RS20745	COG1702	phosphate starvation-inducible protein PhoH
I5M60_RS20755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M60_RS20795	COG0367	asparagine synthase
I5M60_RS20800	COG0647	UMP catabolic process
I5M60_RS20805	COG1940	carbohydrate kinase activity
I5M60_RS20805	COG1846	Transcriptional regulator
I5M60_RS20810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5M60_RS20850	COG0735	belongs to the Fur family
I5M60_RS20865	COG0596	Alpha beta hydrolase
I5M60_RS20875	COG0033	Phosphoglucomutase
I5M60_RS20885	COG0745	RESPONSE REGULATOR receiver
I5M60_RS20890	COG2205	protein histidine kinase activity
I5M60_RS20920	COG0415	Belongs to the DNA photolyase family
I5M60_RS20935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5M60_RS20940	COG1984	allophanate hydrolase subunit 2
I5M60_RS20975	COG2009	succinate dehydrogenase
I5M60_RS20980	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5M60_RS20985	COG1053	succinate dehydrogenase
I5M60_RS20990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M60_RS20995	COG0567	Dehydrogenase, E1 component
I5M60_RS21000	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M60_RS21010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5M60_RS21015	COG1271	oxidase subunit
I5M60_RS21020	COG1294	oxidase, subunit
I5M60_RS21025	COG4890	Cyd operon protein YbgT
I5M60_RS21030	COG3790	cyd operon protein YbgE
I5M60_RS21035	COG0824	Thioesterase
I5M60_RS21040	COG0811	peptide transport
I5M60_RS21045	COG0848	biopolymer transport protein
I5M60_RS21050	COG3064	Membrane
I5M60_RS21060	COG2885	chlorophyll binding
I5M60_RS21065	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5M60_RS21110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5M60_RS21115	COG3201	nicotinamide mononucleotide transporter
I5M60_RS21130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M60_RS21140	COG2017	converts alpha-aldose to the beta-anomer
I5M60_RS21150	COG1085	galactose-1-phosphate uridylyltransferase
I5M60_RS21160	COG1119	ATPase activity
I5M60_RS21165	COG2005	Transcriptional regulator
I5M60_RS21165	COG3585	molybdate ion transport
I5M60_RS21175	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5M60_RS21180	COG4149	molybdate abc transporter
I5M60_RS21185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5M60_RS21190	COG0561	phosphatase activity
I5M60_RS21215	COG2200	EAL domain
I5M60_RS21220	COG0789	Transcriptional regulator
I5M60_RS21255	COG4677	pectinesterase activity
I5M60_RS21295	COG1881	PFAM PEBP family protein
I5M60_RS21300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M60_RS21315	COG2226	methyltransferase
I5M60_RS21340	COG0642	Histidine kinase
I5M60_RS21345	COG0745	RESPONSE REGULATOR receiver
I5M60_RS21365	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M60_RS21375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5M60_RS21380	COG0314	molybdopterin synthase activity
I5M60_RS21385	COG0670	Belongs to the BI1 family
I5M60_RS21390	COG0392	lysyltransferase activity
I5M60_RS21395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M60_RS21400	COG3568	Endonuclease Exonuclease Phosphatase
I5M60_RS21410	COG0842	Transport permease protein
I5M60_RS21415	COG0842	Transport permease protein
I5M60_RS21420	COG1131	(ABC) transporter
I5M60_RS21425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS21430	COG1309	transcriptional regulator
I5M60_RS21435	COG0583	DNA-binding transcription factor activity
I5M60_RS21445	COG2271	Major facilitator Superfamily
I5M60_RS21450	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS21455	COG3959	Transketolase, thiamine diphosphate binding domain
I5M60_RS21460	COG3958	Transketolase
I5M60_RS21465	COG0513	Belongs to the DEAD box helicase family
I5M60_RS21470	COG1199	ATP-dependent helicase activity
I5M60_RS21475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M60_RS21485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5M60_RS21495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M60_RS21505	COG0668	transmembrane transport
I5M60_RS21510	COG1126	abc transporter atp-binding protein
I5M60_RS21515	COG0765	amino acid transport
I5M60_RS21520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS21535	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I5M60_RS21540	COG2194	sulfuric ester hydrolase activity
I5M60_RS21550	COG1321	iron dependent repressor
I5M60_RS21555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M60_RS21560	COG2723	6-phospho-beta-galactosidase activity
I5M60_RS21565	COG2188	Transcriptional regulator
I5M60_RS21570	COG1376	ErfK ybiS ycfS ynhG family protein
I5M60_RS21575	COG2365	Tyrosine phosphatase family
I5M60_RS21580	COG0488	(ABC) transporter
I5M60_RS21590	COG2271	Major facilitator Superfamily
I5M60_RS21595	COG1609	Transcriptional regulator
I5M60_RS21605	COG0561	phosphatase activity
I5M60_RS21610	COG1882	Formate acetyltransferase
I5M60_RS21615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M60_RS21620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M60_RS21625	COG0303	'Molybdopterin
I5M60_RS21640	COG0747	negative chemotaxis
I5M60_RS21660	COG2223	nitrite transmembrane transporter activity
I5M60_RS21670	COG2133	pyrroloquinoline quinone binding
I5M60_RS21675	COG0625	glutathione transferase activity
I5M60_RS21685	COG1686	Belongs to the peptidase S11 family
I5M60_RS21690	COG1349	DNA-binding transcription factor activity
I5M60_RS21695	COG0671	phosphoesterase, PA-phosphatase related
I5M60_RS21700	COG2814	Major facilitator Superfamily
I5M60_RS21705	COG0561	phosphatase activity
I5M60_RS21710	COG0738	Major facilitator superfamily
I5M60_RS21715	COG3226	Transcriptional regulator
I5M60_RS21720	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5M60_RS21725	COG3344	reverse transcriptase
I5M60_RS21750	COG4695	Portal protein
I5M60_RS21945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M60_RS21950	COG3842	ATPase activity
I5M60_RS21955	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M60_RS21960	COG1177	transmembrane transport
I5M60_RS21975	COG0745	RESPONSE REGULATOR receiver
I5M60_RS21980	COG5002	protein histidine kinase activity
I5M60_RS21985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS21990	COG4160	amino acid transport
I5M60_RS21995	COG4215	(ABC) transporter
I5M60_RS22000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M60_RS22005	COG1126	abc transporter atp-binding protein
I5M60_RS22015	COG2203	Gaf domain
I5M60_RS22015	COG5001	Diguanylate cyclase
I5M60_RS22015	COG3706	GGDEF domain
I5M60_RS22015	COG4251	negative regulation of phosphorylation
I5M60_RS22020	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5M60_RS22025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M60_RS22030	COG0702	epimerase
I5M60_RS22035	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5M60_RS22040	COG0028	Belongs to the TPP enzyme family
I5M60_RS22050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M60_RS22060	COG2431	L-lysine efflux transmembrane transporter activity
I5M60_RS22070	COG3593	DNA synthesis involved in DNA repair
I5M60_RS22075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M60_RS22085	COG1278	Cold shock
I5M60_RS22095	COG0542	response to heat
I5M60_RS22110	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5M60_RS22115	COG4988	ABC transporter
I5M60_RS22120	COG0492	ferredoxin-NADP+ reductase activity
I5M60_RS22130	COG1674	ftsk spoiiie
I5M60_RS22130	COG1178	ABC-type Fe3 transport system permease component
I5M60_RS22140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5M60_RS22150	COG0243	molybdopterin cofactor binding
I5M60_RS22155	COG0437	4 iron, 4 sulfur cluster binding
I5M60_RS22160	COG3302	dmso reductase anchor subunit
I5M60_RS22165	COG0477	Major facilitator Superfamily
I5M60_RS22170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M60_RS22175	COG1882	Formate acetyltransferase
I5M60_RS22180	COG2116	formate transmembrane transporter activity
I5M60_RS22185	COG1944	ATP diphosphatase activity
I5M60_RS22190	COG2323	membrane
I5M60_RS22210	COG0539	negative regulation of cytoplasmic translation
I5M60_RS22220	COG2333	competence protein COMEC
I5M60_RS22220	COG0658	competence protein
I5M60_RS22235	COG3214	Protein conserved in bacteria
I5M60_RS22250	COG3173	Aminoglycoside phosphotransferase
I5M60_RS22255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M60_RS22260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5M60_RS22270	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I5M60_RS22280	COG2989	Protein conserved in bacteria
I5M60_RS22285	COG3108	Peptidase M15
I5M60_RS22290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M60_RS22295	COG1448	Aminotransferase
I5M60_RS22300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M60_RS22320	COG0814	amino acid
I5M60_RS22330	COG1473	amidohydrolase
I5M60_RS22340	COG0308	aminopeptidase N
I5M60_RS22350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M60_RS22355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M60_RS22360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M60_RS22365	COG0431	NADPH-dependent FMN reductase
I5M60_RS22380	COG0633	Ferredoxin
I5M60_RS22380	COG3217	Mosc domain protein beta barrel domain protein
I5M60_RS22390	COG0488	(ABC) transporter
I5M60_RS22395	COG2995	paraquat-inducible protein a
I5M60_RS22400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M60_RS22400	COG3008	intermembrane lipid transfer
I5M60_RS22405	COG3009	Protein conserved in bacteria
I5M60_RS22410	COG3130	regulation of translation
I5M60_RS22420	COG1067	ATP-dependent peptidase activity
I5M60_RS22440	COG3070	regulator of competence-specific genes
I5M60_RS22445	COG1289	transmembrane transporter activity
I5M60_RS22450	COG3304	Inner membrane component domain
I5M60_RS22455	COG0210	DNA helicase
I5M60_RS22465	COG1832	CoA-binding protein
I5M60_RS22480	COG1881	PFAM PEBP family protein
I5M60_RS22485	COG2207	Transcriptional regulator
I5M60_RS22500	COG0670	Belongs to the BI1 family
I5M60_RS22540	COG1396	sequence-specific DNA binding
I5M60_RS22565	COG0305	Participates in initiation and elongation during chromosome replication
I5M60_RS22730	COG0741	lytic transglycosylase activity
I5M60_RS22755	COG3772	lysozyme
I5M60_RS22815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M60_RS22820	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS22825	COG4638	Rieske (2fe-2S)
I5M60_RS22830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M60_RS22835	COG0473	3-isopropylmalate dehydrogenase activity
I5M60_RS22840	COG0583	DNA-binding transcription factor activity
I5M60_RS22845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M60_RS22850	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS22855	COG1917	Cupin 2, conserved barrel domain protein
I5M60_RS22855	COG1396	sequence-specific DNA binding
I5M60_RS22860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5M60_RS22865	COG0174	glutamine synthetase
I5M60_RS22870	COG0531	amino acid
I5M60_RS22885	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS22915	COG3729	General stress protein
I5M60_RS22925	COG2233	PERMEase
I5M60_RS22960	COG1309	transcriptional regulator
I5M60_RS22975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5M60_RS22985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M60_RS23005	COG1702	phosphate starvation-inducible protein PhoH
I5M60_RS23010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M60_RS23020	COG1335	isochorismatase
I5M60_RS23030	COG0583	DNA-binding transcription factor activity
I5M60_RS23060	COG3381	protein complex oligomerization
I5M60_RS23095	COG5645	(Lipo)protein
I5M60_RS23110	COG1560	Kdo2-lipid A biosynthetic process
I5M60_RS23155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M60_RS23175	COG2814	Major facilitator Superfamily
I5M60_RS23180	COG0583	DNA-binding transcription factor activity
I5M60_RS23185	COG1530	ribonuclease E activity
I5M60_RS23205	COG1399	metal-binding, possibly nucleic acid-binding protein
I5M60_RS23225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M60_RS23240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M60_RS23245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5M60_RS23250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5M60_RS23260	COG0470	DNA polymerase III
I5M60_RS23265	COG0084	hydrolase, TatD family'
I5M60_RS23275	COG0537	adenosine 5'-monophosphoramidase activity
I5M60_RS23280	COG5633	Lipoprotein
I5M60_RS23305	COG1252	NADH dehydrogenase
I5M60_RS23310	COG3134	Outer membrane lipoprotein
I5M60_RS23325	COG1309	transcriptional regulator
I5M60_RS23340	COG1388	LysM domain
I5M60_RS23340	COG1376	ErfK ybiS ycfS ynhG family protein
I5M60_RS23345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5M60_RS23355	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M60_RS23365	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M60_RS23375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5M60_RS23385	COG0318	PFAM AMP-dependent synthetase and ligase
I5M60_RS23400	COG1177	transmembrane transport
I5M60_RS23420	COG2850	peptidyl-arginine hydroxylation
I5M60_RS23425	COG2205	protein histidine kinase activity
I5M60_RS23445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5M60_RS23465	COG1187	pseudouridine synthase activity
I5M60_RS23470	COG0538	isocitrate dehydrogenase activity
I5M60_RS23475	COG0640	Transcriptional regulator
I5M60_RS23495	COG3813	Protein conserved in bacteria
I5M60_RS23500	COG1063	alcohol dehydrogenase
I5M60_RS23505	COG3729	General stress protein
I5M60_RS23510	COG3685	Protein conserved in bacteria
I5M60_RS23515	COG3685	Protein conserved in bacteria
I5M60_RS23520	COG3546	catalase activity
I5M60_RS23525	COG1271	oxidase subunit
I5M60_RS23530	COG1294	oxidase, subunit
I5M60_RS23560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M60_RS23565	COG0583	DNA-binding transcription factor activity
I5M60_RS23570	COG3706	GGDEF domain
I5M60_RS23575	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5M60_RS23585	COG1560	Kdo2-lipid A biosynthetic process
I5M60_RS23595	COG3182	Iron-regulated membrane protein
I5M60_RS23615	COG2199	diguanylate cyclase activity
I5M60_RS23615	COG2203	Gaf domain
I5M60_RS23620	COG3042	response to heat
I5M60_RS23625	COG3189	MarR family transcriptional regulator
I5M60_RS23630	COG1683	Conserved Protein
I5M60_RS23635	COG0504	CTP synthase activity
I5M60_RS23640	COG2807	transmembrane transport
I5M60_RS23645	COG2207	Transcriptional regulator
I5M60_RS23655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M60_RS23660	COG0859	PFAM glycosyl transferase family 9
I5M60_RS23670	COG3344	reverse transcriptase
I5M60_RS23675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5M60_RS23680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5M60_RS23685	COG0583	DNA-binding transcription factor activity
I5M60_RS23690	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS23715	COG0386	Belongs to the glutathione peroxidase family
I5M60_RS23730	COG2766	serine protein kinase
I5M60_RS23735	COG3713	MltA-interacting MipA family protein
I5M60_RS23740	COG0656	L-ascorbic acid biosynthetic process
I5M60_RS23760	COG3139	Protein of unknown function (DUF1315)
I5M60_RS23775	COG1063	alcohol dehydrogenase
I5M60_RS23780	COG2271	Major facilitator Superfamily
I5M60_RS23785	COG1063	alcohol dehydrogenase
I5M60_RS23790	COG0191	fructose-bisphosphate aldolase activity
I5M60_RS23795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS23800	COG0667	Aldo Keto reductase
I5M60_RS23805	COG1349	DNA-binding transcription factor activity
I5M60_RS23810	COG2814	Major facilitator Superfamily
I5M60_RS23815	COG1335	isochorismatase
I5M60_RS23820	COG0252	asparaginase activity
I5M60_RS23825	COG0616	signal peptide processing
I5M60_RS23830	COG0778	Nitroreductase
I5M60_RS23845	COG0709	Synthesizes selenophosphate from selenide and ATP
I5M60_RS23850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M60_RS23855	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS23855	COG3321	synthase
I5M60_RS23855	COG0604	alcohol dehydrogenase
I5M60_RS23860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M60_RS23865	COG0494	nUDIX hydrolase
I5M60_RS23870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5M60_RS23875	COG2897	thiosulfate sulfurtransferase activity
I5M60_RS23880	COG4136	ATPase activity
I5M60_RS23885	COG4135	transport system, permease component
I5M60_RS23890	COG4134	Bacterial extracellular solute-binding protein
I5M60_RS23895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M60_RS23900	COG0398	Pfam SNARE associated Golgi protein
I5M60_RS23905	COG0398	Pfam SNARE associated Golgi protein
I5M60_RS23910	COG0708	Exodeoxyribonuclease III
I5M60_RS23920	COG3138	arginine N-succinyltransferase
I5M60_RS23930	COG3724	N-succinylarginine dihydrolase activity
I5M60_RS23940	COG3678	ATP-independent chaperone mediated protein folding
I5M60_RS23945	COG0322	excinuclease ABC activity
I5M60_RS23955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M60_RS23960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS23970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M60_RS23975	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M60_RS23980	COG2169	Transcriptional regulator
I5M60_RS23980	COG1917	Cupin 2, conserved barrel domain protein
I5M60_RS23985	COG1486	melibiose metabolic process
I5M60_RS23995	COG0753	catalase activity
I5M60_RS24005	COG1823	symporter activity
I5M60_RS24010	COG1988	membrane-bound metal-dependent
I5M60_RS24015	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS24020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M60_RS24050	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5M60_RS24055	COG3047	cAMP biosynthetic process
I5M60_RS24065	COG4774	siderophore transport
I5M60_RS24120	COG0135	phosphoribosylanthranilate isomerase activity
I5M60_RS24120	COG0134	indole-3-glycerol-phosphate synthase activity
I5M60_RS24125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M60_RS24125	COG0512	Glutamine amidotransferase of anthranilate synthase
I5M60_RS24130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5M60_RS24140	COG0009	L-threonylcarbamoyladenylate synthase
I5M60_RS24150	COG0583	DNA-binding transcription factor activity
I5M60_RS24160	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I5M60_RS24165	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS24175	COG0616	signal peptide processing
I5M60_RS24200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5M60_RS24210	COG0671	phosphoesterase, PA-phosphatase related
I5M60_RS24215	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I5M60_RS24220	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I5M60_RS24230	COG0023	Translation Initiation Factor
I5M60_RS24240	COG1349	DNA-binding transcription factor activity
I5M60_RS24255	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M60_RS24255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M60_RS24260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5M60_RS24270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M60_RS24285	COG4171	peptide transport system, permease
I5M60_RS24300	COG0702	epimerase
I5M60_RS24315	COG1473	amidohydrolase
I5M60_RS24325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M60_RS24330	COG1842	Phage shock protein A
I5M60_RS24340	COG1983	PspC domain protein
I5M60_RS24350	COG3106	COG3106 Predicted ATPase
I5M60_RS24360	COG0583	DNA-binding transcription factor activity
I5M60_RS24365	COG1486	melibiose metabolic process
I5M60_RS24375	COG3180	Ammonia monooxygenase
I5M60_RS24380	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5M60_RS24385	COG4948	Mandelate Racemase Muconate Lactonizing
I5M60_RS24390	COG2866	Carboxypeptidase
I5M60_RS24400	COG4166	transmembrane transport
I5M60_RS24430	COG0656	L-ascorbic acid biosynthetic process
I5M60_RS24450	COG0583	DNA-binding transcription factor activity
I5M60_RS24455	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS24460	COG1078	dGTPase activity
I5M60_RS24465	COG0693	protein deglycase activity
I5M60_RS24470	COG0582	viral genome integration into host DNA
I5M60_RS24575	COG0484	heat shock protein binding
I5M60_RS24585	COG3772	lysozyme
I5M60_RS24605	COG1783	phage Terminase large subunit
I5M60_RS24610	COG3567	Phage-associated protein, HI1409 family
I5M60_RS24680	COG0739	heme binding
I5M60_RS24680	COG1196	nuclear chromosome segregation
I5M60_RS24680	COG0741	lytic transglycosylase activity
I5M60_RS24765	COG3344	reverse transcriptase
I5M60_RS24800	COG2885	chlorophyll binding
I5M60_RS24895	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS24900	COG1309	transcriptional regulator
I5M60_RS24905	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS24925	COG0583	DNA-binding transcription factor activity
I5M60_RS24955	COG0604	alcohol dehydrogenase
I5M60_RS24960	COG0436	Aminotransferase
I5M60_RS24975	COG2011	ABC-type metal ion transport system permease component
I5M60_RS24980	COG1448	Aminotransferase
I5M60_RS24990	COG1522	sequence-specific DNA binding
I5M60_RS24995	COG1113	amino acid transport
I5M60_RS25010	COG0673	inositol 2-dehydrogenase activity
I5M60_RS25015	COG1349	DNA-binding transcription factor activity
I5M60_RS25025	COG0513	Belongs to the DEAD box helicase family
I5M60_RS25035	COG0589	response to stress
I5M60_RS25045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M60_RS25050	COG1013	pyruvate-flavodoxin oxidoreductase activity
I5M60_RS25050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I5M60_RS25050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M60_RS25050	COG0674	pyruvate-flavodoxin oxidoreductase activity
I5M60_RS25055	COG3042	response to heat
I5M60_RS25060	COG3187	Heat shock protein
I5M60_RS25065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5M60_RS25070	COG0586	Pfam SNARE associated Golgi protein
I5M60_RS25075	COG2911	Protein conserved in bacteria
I5M60_RS25085	COG3784	Protein of unknown function (DUF1318)
I5M60_RS25090	COG2207	Transcriptional regulator
I5M60_RS25095	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS25115	COG2030	dehydratase
I5M60_RS25115	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS25120	COG3396	Phenylacetate-CoA oxygenase
I5M60_RS25125	COG3460	Phenylacetate-CoA oxygenase
I5M60_RS25130	COG3396	Phenylacetate-CoA oxygenase
I5M60_RS25135	COG2151	metal-sulfur cluster biosynthetic enzyme
I5M60_RS25140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M60_RS25145	COG1024	Enoyl-CoA hydratase
I5M60_RS25150	COG1024	Enoyl-CoA hydratase
I5M60_RS25160	COG2050	protein possibly involved in aromatic compounds catabolism
I5M60_RS25165	COG0183	Belongs to the thiolase family
I5M60_RS25170	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5M60_RS25175	COG3327	negative regulation of DNA-templated transcription, initiation
I5M60_RS25180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M60_RS25195	COG1643	Atp-dependent helicase
I5M60_RS25200	COG4122	O-methyltransferase activity
I5M60_RS25225	COG0583	DNA-binding transcription factor activity
I5M60_RS25230	COG0667	Aldo Keto reductase
I5M60_RS25235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M60_RS25245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M60_RS25250	COG3138	arginine N-succinyltransferase
I5M60_RS25255	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS25260	COG3724	N-succinylarginine dihydrolase activity
I5M60_RS25265	COG2988	succinylglutamate desuccinylase activity
I5M60_RS25270	COG1113	amino acid transport
I5M60_RS25275	COG0477	Major facilitator Superfamily
I5M60_RS25280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M60_RS25290	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS25295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5M60_RS25300	COG0401	homolog of Blt101
I5M60_RS25305	COG5562	phage envelope protein
I5M60_RS25310	COG0425	Belongs to the sulfur carrier protein TusA family
I5M60_RS25315	COG2391	methyltransferase activity
I5M60_RS25340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5M60_RS25345	COG1263	PTS System
I5M60_RS25345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M60_RS25350	COG1609	Transcriptional regulator
I5M60_RS25355	COG5339	Protein conserved in bacteria
I5M60_RS25360	COG1482	cell wall glycoprotein biosynthetic process
I5M60_RS25365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M60_RS25365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M60_RS25370	COG0114	fumarate hydratase activity
I5M60_RS25380	COG2205	protein histidine kinase activity
I5M60_RS25390	COG0745	RESPONSE REGULATOR receiver
I5M60_RS25395	COG3136	membrane protein required for alginate biosynthesis
I5M60_RS25405	COG0531	amino acid
I5M60_RS25420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I5M60_RS25425	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I5M60_RS25440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M60_RS25455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5M60_RS25460	COG1473	amidohydrolase
I5M60_RS25470	COG0583	DNA-binding transcription factor activity
I5M60_RS25475	COG2840	Smr protein MutS2
I5M60_RS25480	COG1414	Transcriptional regulator
I5M60_RS25490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M60_RS25495	COG0183	Belongs to the thiolase family
I5M60_RS25505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5M60_RS25510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M60_RS25520	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M60_RS25520	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M60_RS25540	COG4565	transcriptional regulatory protein
I5M60_RS25545	COG3290	protein histidine kinase activity
I5M60_RS25570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M60_RS25580	COG0679	Auxin Efflux Carrier
I5M60_RS25610	COG0628	permease
I5M60_RS25630	COG3591	Belongs to the peptidase S1B family
I5M60_RS25640	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5M60_RS25645	COG2814	Major facilitator Superfamily
I5M60_RS25650	COG0583	DNA-binding transcription factor activity
I5M60_RS25655	COG1940	carbohydrate kinase activity
I5M60_RS25660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5M60_RS25675	COG3302	dmso reductase anchor subunit
I5M60_RS25680	COG0437	4 iron, 4 sulfur cluster binding
I5M60_RS25685	COG0243	molybdopterin cofactor binding
I5M60_RS25700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M60_RS25715	COG2271	Major facilitator Superfamily
I5M60_RS25720	COG0246	Mannitol dehydrogenase
I5M60_RS25725	COG0589	response to stress
I5M60_RS25730	COG1802	Transcriptional regulator
I5M60_RS25735	COG4221	oxidoreductase activity
I5M60_RS25750	COG2207	Transcriptional regulator
I5M60_RS25755	COG2135	peptidase activity
I5M60_RS25770	COG2197	response regulator
I5M60_RS25785	COG0071	Belongs to the small heat shock protein (HSP20) family
I5M60_RS25790	COG1546	Belongs to the CinA family
I5M60_RS25795	COG2200	EAL domain
I5M60_RS25810	COG3708	Transcriptional regulator
I5M60_RS25810	COG2207	Transcriptional regulator
I5M60_RS25815	COG2610	gluconate transmembrane transporter activity
I5M60_RS25820	COG3622	Belongs to the hyi family
I5M60_RS25825	COG0235	Class ii aldolase
I5M60_RS25830	COG3395	kinase activity
I5M60_RS25835	COG2084	Dehydrogenase
I5M60_RS25840	COG1349	DNA-binding transcription factor activity
I5M60_RS25855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5M60_RS25860	COG2223	nitrite transmembrane transporter activity
I5M60_RS25895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5M60_RS25900	COG0683	leucine binding
I5M60_RS25930	COG2814	Major facilitator Superfamily
I5M60_RS25935	COG0697	spore germination
I5M60_RS25945	COG4977	sequence-specific DNA binding
I5M60_RS25975	COG1028	Short-chain dehydrogenase reductase Sdr
I5M60_RS25980	COG2731	YhcH YjgK YiaL family protein
I5M60_RS25995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5M60_RS26005	COG3395	kinase activity
I5M60_RS26010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M60_RS26015	COG1349	DNA-binding transcription factor activity
I5M60_RS26020	COG0039	L-malate dehydrogenase activity
I5M60_RS26030	COG0583	DNA-binding transcription factor activity
I5M60_RS26035	COG1012	belongs to the aldehyde dehydrogenase family
I5M60_RS26050	COG2199	diguanylate cyclase activity
I5M60_RS26120	COG0477	Major facilitator Superfamily
I5M60_RS26130	COG2070	2-Nitropropane dioxygenase
I5M60_RS26135	COG2011	ABC-type metal ion transport system permease component
I5M60_RS26155	COG4628	conserved protein (DUF2132)
I5M60_RS26170	COG2207	Transcriptional regulator
I5M60_RS26200	COG2233	PERMEase
I5M60_RS26205	COG3195	allantoin biosynthetic process
I5M60_RS26205	COG3648	Uricase
I5M60_RS26210	COG2351	hydroxyisourate hydrolase activity
I5M60_RS26215	COG1396	sequence-specific DNA binding
I5M60_RS26220	COG3550	peptidyl-serine autophosphorylation
I5M60_RS26225	COG1649	PFAM Uncharacterised BCR, COG1649
I5M60_RS26235	COG3188	usher protein
I5M60_RS26270	COG5001	Diguanylate cyclase
I5M60_RS26270	COG3300	MHYT domain
I5M60_RS26275	COG2819	hydrolase of the alpha beta superfamily
I5M60_RS26290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS26290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M60_RS26295	COG2814	Major facilitator Superfamily
I5M60_RS26305	COG1263	PTS System
I5M60_RS26305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M60_RS26310	COG2186	Transcriptional regulator
I5M60_RS26330	COG3835	regulator
I5M60_RS26335	COG1929	Belongs to the glycerate kinase type-1 family
I5M60_RS26380	COG0738	Major facilitator superfamily
I5M60_RS26385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M60_RS26390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M60_RS26395	COG1349	DNA-binding transcription factor activity
I5M60_RS26410	COG1349	DNA-binding transcription factor activity
I5M60_RS26415	COG4977	sequence-specific DNA binding
I5M60_RS26435	COG4977	sequence-specific DNA binding
I5M60_RS26450	COG2801	Transposase and inactivated derivatives
I5M60_RS26470	COG0667	Aldo Keto reductase
I5M60_RS26480	COG0667	Aldo Keto reductase
I5M60_RS26485	COG0667	Aldo Keto reductase
I5M60_RS26495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5M60_RS26495	COG0456	acetyltransferase
I5M60_RS26520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M60_RS26520	COG0426	domain, Protein
I5M60_RS26535	COG1652	LysM domain
I5M60_RS26595	COG0583	DNA-binding transcription factor activity
I5M60_RS26660	COG1660	Displays ATPase and GTPase activities
I5M60_RS26715	COG1192	Involved in chromosome partitioning
I5M60_RS26800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M60_RS26895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M60_RS26920	COG5001	Diguanylate cyclase
I5M60_RS26955	COG0714	Associated with various cellular activities
I5M60_RS26965	COG0629	single-stranded DNA binding
I5M60_RS27010	COG0633	Ferredoxin
I5M60_RS27180	COG4974	Belongs to the 'phage' integrase family
I5M60_RS27370	COG0616	signal peptide processing
I5M60_RS27475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5M60_RS27540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M60_RS27780	COG2003	Belongs to the UPF0758 family
I5M60_RS27810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M60_RS27910	COG3344	reverse transcriptase
I5M60_RS27945	COG0583	DNA-binding transcription factor activity