locus-tag class description HJW98_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HJW98_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HJW98_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW98_RS00025 ENOG410667J hydrolase HJW98_RS00040 ENOG4105EMF GntR family transcriptional regulator HJW98_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HJW98_RS00050 ENOG4108RTU Aldolase HJW98_RS00055 ENOG4105CXK mandelate racemase muconate lactonizing HJW98_RS00060 ENOG4105DJB Major Facilitator Superfamily HJW98_RS00065 ENOG4105D99 atp gtp-binding protein HJW98_RS00070 ENOG4105R2A (LipO)protein HJW98_RS00085 ENOG4105F5P DNA-damage-inducible protein d HJW98_RS00090 ENOG4105D0C transport protein HJW98_RS00095 ENOG4105FDP GntR family transcriptional regulator HJW98_RS00100 ENOG4105CI1 PTS System HJW98_RS00105 ENOG4105F8D glycoside hydrolase family 4 HJW98_RS00110 ENOG4105VG5 Membrane HJW98_RS00115 ENOG4105JP4 Inner membrane protein yidG HJW98_RS00140 ENOG4105W8I Transcriptional regulator HJW98_RS00145 ENOG4105E5M Multidrug resistance protein D HJW98_RS00175 ENOG4105C7K acetolactate synthase HJW98_RS00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit HJW98_RS00185 ENOG4108KX4 response regulator HJW98_RS00190 ENOG4105BZU Histidine kinase HJW98_RS00195 ENOG4105CXY transporter HJW98_RS00200 ENOG4105CXY transporter HJW98_RS00205 ENOG4108SAJ Protein of unknown function (DUF1198) HJW98_RS00225 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HJW98_RS00230 ENOG4107STF Involved in phosphonate degradation (By similarity) HJW98_RS00235 ENOG4106S9K Transcriptional regulator HJW98_RS00250 ENOG4108MP3 ABC transporter, permease HJW98_RS00260 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW98_RS00265 ENOG4105VCP PTS System HJW98_RS00270 ENOG4105CK1 PTS System HJW98_RS00280 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS00285 ENOG4105D2S major facilitator superfamily HJW98_RS00295 ENOG4107F9Y LysR family transcriptional regulator HJW98_RS00305 ENOG4105JSC dimethylmenaquinone methyltransferase HJW98_RS00320 ENOG4105T8A Uncharacterized protein YicS HJW98_RS00325 ENOG4108UZ3 Transporter HJW98_RS00330 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HJW98_RS00335 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HJW98_RS00340 ENOG4105C2C drug resistance transporter, Bcr CflA HJW98_RS00345 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJW98_RS00350 ENOG4105BZS acriflavin resistance protein HJW98_RS00355 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW98_RS00375 ENOG410630P Transcriptional regulator HJW98_RS00385 ENOG4105CR8 Transcriptional regulator HJW98_RS00410 ENOG4105D01 (LipO)protein HJW98_RS00425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HJW98_RS00435 ENOG4105DQ4 alcohol dehydrogenase HJW98_RS00455 ENOG4105NI3 Protein of unknown function (DUF3237) HJW98_RS00465 ENOG4105CT4 transporter HJW98_RS00470 ENOG4105CJQ hydrolase, family 31 HJW98_RS00480 ENOG4105F8D glycoside hydrolase family 4 HJW98_RS00485 ENOG4105CI1 PTS System HJW98_RS00490 ENOG4105JV1 AsmA family HJW98_RS00495 ENOG4105C2W permease HJW98_RS00500 ENOG4105D6U Sodium Glutamate Symporter HJW98_RS00505 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HJW98_RS00510 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJW98_RS00515 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HJW98_RS00520 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HJW98_RS00535 ENOG4105CP7 Triose-phosphate isomerase HJW98_RS00540 ENOG4105EBK exported protein HJW98_RS00545 ENOG4108VTS Membrane HJW98_RS00550 ENOG4105DP0 ferredoxin-NADP reductase HJW98_RS00555 ENOG4105CBT Fructose-1,6-bisphosphatase HJW98_RS00560 ENOG4105CB5 ATP-dependent DNA helicase recG HJW98_RS00565 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HJW98_RS00570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HJW98_RS00580 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HJW98_RS00585 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HJW98_RS00590 ENOG4105EN6 Membrane HJW98_RS00600 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJW98_RS00605 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) HJW98_RS00615 ENOG4105DSJ YicC domain protein HJW98_RS00640 ENOG4105CJ1 ABC, transporter HJW98_RS00645 ENOG4107QWP ABC-2 type transporter HJW98_RS00650 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HJW98_RS00660 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HJW98_RS00665 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HJW98_RS00670 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HJW98_RS00675 ENOG4105W5Q DNA repair protein (RadC HJW98_RS00680 ENOG4105KDC 50s ribosomal protein l28 HJW98_RS00685 ENOG4105W0E 50S ribosomal protein L33 HJW98_RS00690 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HJW98_RS00695 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HJW98_RS00700 ENOG4106WTF Glycosyl transferase, family 2 HJW98_RS00705 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HJW98_RS00710 ENOG4105K64 Glycosyl transferase, family 2 HJW98_RS00715 ENOG4105CPK Glycosyl transferase (Group 1 HJW98_RS00725 ENOG4105DKP glycosyl transferase, family 9 HJW98_RS00750 ENOG4105D16 lipopolysaccharide heptosyltransferase i HJW98_RS00755 ENOG4105XA0 heptosyltransferase ii HJW98_RS00760 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HJW98_RS00765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HJW98_RS00770 ENOG4105CPQ Dehydrogenase HJW98_RS00775 ENOG4106WTF Glycosyl transferase, family 2 HJW98_RS00780 ENOG4105PXI polysaccharide deacetylase HJW98_RS00785 ENOG41063SB peptidase HJW98_RS00795 ENOG4107YZP Rhodanese domain protein HJW98_RS00800 ENOG4105VW4 glutaredoxin 3 HJW98_RS00805 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HJW98_RS00810 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HJW98_RS00815 ENOG4105D7W serine acetyltransferase HJW98_RS00820 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HJW98_RS00825 ENOG4105DMF Dehydrogenase HJW98_RS00830 ENOG41073TP transcriptional regulator HJW98_RS00835 ENOG4105DAA L-lactate HJW98_RS00840 ENOG4108YYI Protein of unknown function (DUF2810) HJW98_RS00850 ENOG4105E61 Mannitol repressor protein HJW98_RS00855 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HJW98_RS00860 ENOG4105CTS PTS system mannitol-specific HJW98_RS00865 ENOG4108U78 Glutathione S-transferase HJW98_RS00870 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HJW98_RS00875 ENOG4105EM7 Selenocysteine-specific translation elongation factor HJW98_RS00880 ENOG4105J4Q Transcriptional regulator HJW98_RS00885 ENOG4108RC0 Electron transport protein HJW98_RS00890 ENOG4105JKW Valine--pyruvate aminotransferase HJW98_RS00895 ENOG4107T9C Alpha amylase catalytic region HJW98_RS00900 ENOG4108UR8 BAX protein HJW98_RS00905 ENOG4105T16 Transcriptional regulator (AraC family) HJW98_RS00910 ENOG4108HWW ABC transporter HJW98_RS00920 ENOG4105DFW ABC transporter HJW98_RS00925 ENOG4105C93 Xylose Isomerase HJW98_RS00930 ENOG4105CMG Carbohydrate kinase HJW98_RS00935 ENOG410688U Inner membrane protein yiaB HJW98_RS00940 ENOG4108Z12 YiaAB two helix domain-containing protein HJW98_RS00945 ENOG4105MEV Acyl-transferase HJW98_RS00955 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HJW98_RS00960 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HJW98_RS00965 ENOG41060TC Hok gef cell toxic protein HJW98_RS00970 ENOG4105C5H ABC transporter HJW98_RS00980 ENOG4105MVF Transcriptional regulator HJW98_RS00985 ENOG4105D2S major facilitator superfamily HJW98_RS00990 ENOG4106JH6 (LipO)protein HJW98_RS00995 ENOG4105C5I Dehydrogenase HJW98_RS01005 ENOG4105D7K pfkb domain protein HJW98_RS01015 ENOG4108M60 Transcriptional regulator HJW98_RS01025 ENOG4108ZG0 Ompa motb domain protein HJW98_RS01030 ENOG4107QY8 reductase HJW98_RS01035 ENOG4105HNP -acetyltransferase HJW98_RS01040 ENOG4108R3E Dna-3-methyladenine glycosylase i HJW98_RS01045 ENOG4105EAX Putative lipase HJW98_RS01050 ENOG4105FCD Major Facilitator HJW98_RS01055 ENOG4105DIJ Phosphoethanolamine transferase HJW98_RS01080 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW98_RS01085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW98_RS01090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW98_RS01095 ENOG4105C3U ABC transporter HJW98_RS01100 ENOG4108JQ7 (ABC) transporter HJW98_RS01115 ENOG4107U53 septum site-determining protein minD HJW98_RS01120 ENOG4107QZ7 Cellulose synthase catalytic subunit HJW98_RS01125 ENOG4107EEX Cellulose synthase regulator protein HJW98_RS01130 ENOG4105EJG cellulose synthase HJW98_RS01145 ENOG4105D1V cellulose synthase operon protein YhjU HJW98_RS01150 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HJW98_RS01155 ENOG4105U74 cellulose biosynthesis protein BcsE HJW98_RS01160 ENOG410661M cytoplasmic protein HJW98_RS01165 ENOG4105UTS cellulose synthase operon protein YhjQ HJW98_RS01170 ENOG4107QZ7 Cellulose synthase catalytic subunit HJW98_RS01175 ENOG4107EEX Cellulose synthase regulator protein HJW98_RS01180 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HJW98_RS01185 ENOG4105EJG cellulose synthase HJW98_RS01190 ENOG4105BZU Histidine kinase HJW98_RS01195 ENOG4105CK2 sodium dicarboxylate symporter HJW98_RS01200 ENOG4105CS0 peptidase HJW98_RS01215 ENOG41066T0 asmA family HJW98_RS01220 ENOG4105CSH Transporter HJW98_RS01225 ENOG4107H3J ribonuclease HJW98_RS01230 ENOG4105CBN LysR family transcriptional regulator HJW98_RS01235 ENOG4105CHR reductase HJW98_RS01250 ENOG4105C0A alcohol dehydrogenase HJW98_RS01260 ENOG4105DC8 reductase HJW98_RS01265 ENOG4105D6S protein involved in catabolism of external DNA HJW98_RS01270 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HJW98_RS01275 ENOG4105DGW oligopeptidase A HJW98_RS01280 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HJW98_RS01285 ENOG4105DUX Transporter HJW98_RS01295 ENOG4108V6B universal stress protein B HJW98_RS01300 ENOG4105CJ3 phosphate transporter HJW98_RS01305 ENOG4105CBX hi0933 family HJW98_RS01310 ENOG4105CJW magnesium transporter HJW98_RS01325 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS01335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW98_RS01340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW98_RS01345 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HJW98_RS01355 ENOG4105PY6 Phenolic acid decarboxylase HJW98_RS01360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HJW98_RS01365 ENOG4105CKK Glycosyl transferase, family 2 HJW98_RS01370 ENOG4105C3I Nad-dependent epimerase dehydratase HJW98_RS01375 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HJW98_RS01380 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HJW98_RS01385 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HJW98_RS01390 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HJW98_RS01395 ENOG4105DSF transport protein HJW98_RS01400 ENOG4105F9N Major Facilitator Superfamily HJW98_RS01405 ENOG4108W1V Lipoprotein HJW98_RS01410 ENOG4105EX9 Membrane HJW98_RS01415 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HJW98_RS01425 ENOG4107FS9 Membrane HJW98_RS01435 ENOG4105MG3 Membrane HJW98_RS01440 ENOG4106H78 methyltransferase HJW98_RS01445 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HJW98_RS01450 ENOG4105CAK Cell division ATP-binding protein ftsE HJW98_RS01455 ENOG4105CRP Part of the ABC transporter FtsEX involved in HJW98_RS01470 ENOG4108JPW Aminotransferase HJW98_RS01480 ENOG4105CP9 extracellular ligand-binding receptor HJW98_RS01485 ENOG4105EG3 transmembrane signal peptide protein HJW98_RS01490 ENOG4108V0P LemA family HJW98_RS01495 ENOG4105U59 -acetyltransferase HJW98_RS01500 ENOG4105CP9 extracellular ligand-binding receptor HJW98_RS01505 ENOG4105C32 Amino acid ABC transporter (Permease) HJW98_RS01510 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJW98_RS01515 ENOG4105C0Z ABC transporter HJW98_RS01520 ENOG4108IV0 ABC, transporter HJW98_RS01525 ENOG41060M8 Pfam:PhdYeFM HJW98_RS01535 ENOG4105BZ7 extracellular solute-binding protein family 1 HJW98_RS01540 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HJW98_RS01555 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HJW98_RS01560 ENOG4105WC8 Conserved Protein HJW98_RS01565 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HJW98_RS01570 ENOG4105WCN acetyltransferase HJW98_RS01580 ENOG4105D9R oxidoreductase HJW98_RS01585 ENOG4105C2I pirin domain protein HJW98_RS01590 ENOG4105DIQ Transcriptional regulator HJW98_RS01595 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HJW98_RS01600 ENOG4105C6Z Gluconate HJW98_RS01610 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJW98_RS01615 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HJW98_RS01620 ENOG4108IUM Glycogen debranching enzyme HJW98_RS01625 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HJW98_RS01630 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HJW98_RS01635 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HJW98_RS01640 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HJW98_RS01645 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HJW98_RS01650 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HJW98_RS01655 ENOG4105E98 transcriptional regulator DeoR family HJW98_RS01660 ENOG41061ZR Transcriptional regulator HJW98_RS01665 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HJW98_RS01670 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HJW98_RS01675 ENOG4105C6Z Gluconate HJW98_RS01680 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HJW98_RS01685 ENOG4105MJ2 Competence protein HJW98_RS01690 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HJW98_RS01700 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HJW98_RS01705 ENOG4105CE1 Ferrous iron transport protein b HJW98_RS01710 ENOG4105XFK Ferrous iron transport protein A HJW98_RS01715 ENOG4105BZM domain protein HJW98_RS01720 ENOG4108RRZ Transcription elongation factor GreB HJW98_RS01730 ENOG4105E0F Histidine kinase HJW98_RS01745 ENOG4105VEJ Heat shock protein HJW98_RS01750 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HJW98_RS01755 ENOG4105DQY intracellular growth attenuator HJW98_RS01760 ENOG4107RK2 ADP-ribose diphosphatase NudE HJW98_RS01765 ENOG4108JQC penicillin-binding protein 1A HJW98_RS01790 ENOG4105E4G Type IV pilus HJW98_RS01795 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HJW98_RS01800 ENOG4105D49 3-dehydroquinate synthase HJW98_RS01805 ENOG4105EGB membrane protein DamX HJW98_RS01810 ENOG4105DFE Dna adenine methylase HJW98_RS01815 ENOG4105DJV ribulose-phosphate 3-epimerase HJW98_RS01825 ENOG4105C31 Tryptophanyl-tRNA synthetase HJW98_RS01830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HJW98_RS01835 ENOG4105WZK nitrite reductase NADPH small subunit HJW98_RS01840 ENOG4107QZF nitrite reductase NADPH large subunit HJW98_RS01850 ENOG4105DZC cytosine deaminase HJW98_RS01855 ENOG4106DTQ Protein TsgA homolog HJW98_RS01860 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HJW98_RS01865 ENOG4106195 uncharacterized protein yhfG HJW98_RS01870 ENOG4105MZU cell filamentation protein HJW98_RS01880 ENOG4105C8Y Acetylornithine aminotransferase HJW98_RS01885 ENOG410613R integral membrane protein, YccS YhfK family HJW98_RS01890 ENOG4107RYR Transcriptional regulator, Crp Fnr family HJW98_RS01895 ENOG4108UKZ OsmC family HJW98_RS01900 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HJW98_RS01905 ENOG4105YP7 UPF0270 protein HJW98_RS01910 ENOG4105DNZ Alpha Beta Hydrolase HJW98_RS01920 ENOG4105C5H ABC transporter HJW98_RS01925 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HJW98_RS01930 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJW98_RS01935 ENOG4105VKU nucleicacid-binding protein HJW98_RS01940 ENOG4108YZY peptidylprolyl cis-trans isomerase HJW98_RS01945 ENOG4105VRX Protein slyX homolog HJW98_RS01950 ENOG4108V1T peptidylprolyl cis-trans isomerase HJW98_RS01955 ENOG4105WWK YheO domain protein HJW98_RS01960 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HJW98_RS01965 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HJW98_RS01970 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HJW98_RS01975 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HJW98_RS01980 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HJW98_RS01985 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HJW98_RS01990 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HJW98_RS01995 ENOG4105W53 bacterioferritin-associated ferredoxin HJW98_RS02000 ENOG4108UQY Iron-storage protein HJW98_RS02015 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HJW98_RS02020 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HJW98_RS02030 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HJW98_RS02035 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HJW98_RS02040 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HJW98_RS02045 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HJW98_RS02050 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HJW98_RS02055 ENOG41083MP 50s ribosomal protein l29 HJW98_RS02060 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HJW98_RS02065 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HJW98_RS02070 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HJW98_RS02085 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HJW98_RS02090 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HJW98_RS02100 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HJW98_RS02105 ENOG4105VPB 50S ribosomal protein L30 HJW98_RS02110 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HJW98_RS02115 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HJW98_RS02120 ENOG41067V7 50S ribosomal protein L36 HJW98_RS02125 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HJW98_RS02130 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HJW98_RS02135 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HJW98_RS02140 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJW98_RS02145 ENOG4108ZT0 50S ribosomal protein l17 HJW98_RS02150 ENOG4105VTS DnaJ-like, subfamily C HJW98_RS02155 ENOG4105W1Y Transcriptional regulator HJW98_RS02160 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HJW98_RS02165 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HJW98_RS02170 ENOG4105C1A potassium transporter peripheral membrane HJW98_RS02175 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HJW98_RS02180 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HJW98_RS02185 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HJW98_RS02190 ENOG4105C79 DNA protecting protein DprA HJW98_RS02200 ENOG4108WI1 Dna topoisomerase HJW98_RS02205 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HJW98_RS02210 ENOG4105E2X shikimate dehydrogenase HJW98_RS02215 ENOG4105SG3 Protein of unknown function (DUF1488) HJW98_RS02220 ENOG4108Z0R Transferase HJW98_RS02250 ENOG4105XCM membrane LIPOPROTEIN HJW98_RS02255 ENOG4105BZS acriflavin resistance protein HJW98_RS02260 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW98_RS02265 ENOG4108XG4 DNA-binding transcriptional regulator HJW98_RS02275 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HJW98_RS02280 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HJW98_RS02285 ENOG4108IA2 Sodium pantothenate symporter HJW98_RS02290 ENOG4105RG0 Membrane HJW98_RS02295 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HJW98_RS02300 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HJW98_RS02310 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HJW98_RS02325 ENOG41062P1 Diguanylate cyclase phosphodiesterase HJW98_RS02335 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HJW98_RS02340 ENOG4105VQ7 Rod shape-determining protein MreD HJW98_RS02345 ENOG4108Z03 MAF-like protein HJW98_RS02350 ENOG4105C03 ribonuclease HJW98_RS02355 ENOG4105QD6 exported protein HJW98_RS02360 ENOG4105D1U peptidase U62 modulator of DNA gyrase HJW98_RS02365 ENOG4105CR8 Transcriptional regulator HJW98_RS02380 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HJW98_RS02385 ENOG4105UNR (Barnase) inhibitor HJW98_RS02390 ENOG4105RID UPF0379 protein yhcN HJW98_RS02395 ENOG4105RID UPF0379 protein yhcN HJW98_RS02400 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HJW98_RS02405 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HJW98_RS02420 ENOG4105C8P )-transporter HJW98_RS02425 ENOG4106DSS Tartrate dehydratase subunit alpha HJW98_RS02430 ENOG4107GFK fumarate HJW98_RS02440 ENOG4107QSA Oxaloacetate decarboxylase HJW98_RS02445 ENOG4105D9Q decarboxylase (Beta subunit) HJW98_RS02455 ENOG4105C0H protease HJW98_RS02460 ENOG4105C0H protease HJW98_RS02465 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HJW98_RS02470 ENOG4105D6Z AFG1 family ATPase HJW98_RS02475 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HJW98_RS02490 ENOG4107MKT Stringent starvation protein a HJW98_RS02495 ENOG4105KB2 stringent starvation protein b HJW98_RS02500 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HJW98_RS02505 ENOG4105BZ8 glutamate synthase HJW98_RS02510 ENOG4105CBC glutamate synthase HJW98_RS02515 ENOG4105N5T Radical SAM Protein HJW98_RS02520 ENOG4108I5G Major Facilitator superfamily HJW98_RS02525 ENOG4105CPQ Dehydrogenase HJW98_RS02535 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HJW98_RS02540 ENOG4105BZU Histidine kinase HJW98_RS02545 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HJW98_RS02555 ENOG41080Z8 PHOSPHOCARRIER protein HJW98_RS02560 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HJW98_RS02565 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HJW98_RS02570 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HJW98_RS02575 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJW98_RS02580 ENOG4108IUZ ABC transporter HJW98_RS02585 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HJW98_RS02590 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HJW98_RS02595 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HJW98_RS02600 ENOG4105C2X Arabinose 5-phosphate isomerase HJW98_RS02605 ENOG4105FEU K -dependent Na -Ca exchanger HJW98_RS02610 ENOG4105DHJ ABC, transporter HJW98_RS02615 ENOG4105CY3 ABC transporter, permease HJW98_RS02620 ENOG4107PE3 Mammalian cell entry related domain protein HJW98_RS02625 ENOG4105E3I toluene tolerance HJW98_RS02630 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HJW98_RS02635 ENOG4105VFK BolA family HJW98_RS02640 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HJW98_RS02645 ENOG4105HVQ Regulatory factor of maltose metabolism HJW98_RS02650 ENOG4105EAH synthase HJW98_RS02655 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HJW98_RS02660 ENOG4105K46 50S ribosomal protein l27 HJW98_RS02665 ENOG4105QYV Membrane HJW98_RS02670 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HJW98_RS02675 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HJW98_RS02680 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HJW98_RS02685 ENOG4105HBR Rna-binding protein HJW98_RS02690 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HJW98_RS02695 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HJW98_RS02700 ENOG4105EEI dihydropteroate synthase HJW98_RS02705 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HJW98_RS02710 ENOG4105NTZ Preprotein translocase subunit SecG HJW98_RS02725 ENOG4108UII YfaZ family HJW98_RS02730 ENOG4108PNB DNA-binding transcriptional regulator HJW98_RS02735 ENOG4105CDH Citrulline--aspartate ligase HJW98_RS02750 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HJW98_RS02755 ENOG4105CHV Transcription elongation factor NusA HJW98_RS02760 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HJW98_RS02765 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HJW98_RS02770 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HJW98_RS02775 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HJW98_RS02780 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HJW98_RS02795 ENOG4105C1J atp-dependent rna helicase HJW98_RS02800 ENOG4105CIC tryptophan-specific transport protein HJW98_RS02805 ENOG4105DEN Luciferase family HJW98_RS02825 ENOG4108YYD acetyltransferase HJW98_RS02830 ENOG41082IR Excinuclease ABC C subunit domain protein HJW98_RS02835 ENOG4108ZPB UPF0306 protein HJW98_RS02840 ENOG4107R7Y intracellular protease Pfpi family HJW98_RS02845 ENOG4105K4T epimerase HJW98_RS02850 ENOG4107S21 permease HJW98_RS02855 ENOG4105W4M Transport-associated protein HJW98_RS02860 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HJW98_RS02865 ENOG41082RQ UPF0102 protein HJW98_RS02870 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HJW98_RS02875 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HJW98_RS02880 ENOG4105CTX dehydratase HJW98_RS02890 ENOG4105DJB Major Facilitator Superfamily HJW98_RS02895 ENOG4105CNV Aldolase HJW98_RS02900 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HJW98_RS02905 ENOG4105BZW Glycerate kinase HJW98_RS02930 ENOG4106D80 Uncharacterized protein YhaL HJW98_RS02935 ENOG4108CNN domain protein HJW98_RS02940 ENOG4105CWB LysR family transcriptional Regulator HJW98_RS02945 ENOG4105KAF membrAne HJW98_RS02950 ENOG4105CHF Glutathione S-transferase HJW98_RS02955 ENOG4108VBZ doxx family HJW98_RS02960 ENOG4105YJD HJW98_RS02965 ENOG41090KG Inner membrane protein YqjE HJW98_RS02970 ENOG4105NE1 Conserved Protein HJW98_RS02975 ENOG4105WAY exported protein HJW98_RS02980 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HJW98_RS02985 ENOG4106W5V Membrane HJW98_RS02990 ENOG4107YCY Transcriptional regulator HJW98_RS02995 ENOG4105DPW Major facilitator superfamily MFS_1 HJW98_RS03005 ENOG4105CTX dehydratase HJW98_RS03010 ENOG4105P66 Membrane HJW98_RS03015 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HJW98_RS03020 ENOG4105DU1 integral membrane protein, terc HJW98_RS03025 ENOG4105EE0 oxidoreductase HJW98_RS03030 ENOG4108VKG metal-dependent hydrolase HJW98_RS03045 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HJW98_RS03050 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJW98_RS03055 ENOG4107RYS Autoinducer-2 (AI-2) kinase HJW98_RS03060 ENOG4105DKT Transcriptional regulator HJW98_RS03065 ENOG4105C2J ABC transporter HJW98_RS03070 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HJW98_RS03075 ENOG4105F5R ABC transporter HJW98_RS03080 ENOG4105D4B ABC, transporter HJW98_RS03085 ENOG41061GT Aldolase HJW98_RS03090 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HJW98_RS03095 ENOG4105C8Y Acetylornithine aminotransferase HJW98_RS03100 ENOG4105NTW Transcriptional regulator HJW98_RS03110 ENOG4105Q26 Siderophore-interacting protein HJW98_RS03125 ENOG4108UTZ Dihydroxyacetone kinase HJW98_RS03130 ENOG4105CMT Dihydroxyacetone kinase HJW98_RS03160 ENOG4105C0A alcohol dehydrogenase HJW98_RS03175 ENOG4105YCI dehydratase medium subunit HJW98_RS03180 ENOG4108ZFT Dehydratase small subunit HJW98_RS03185 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HJW98_RS03190 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJW98_RS03195 ENOG4105XXV Acid-resistance protein HJW98_RS03200 ENOG4108YK4 Acid-resistance membrane protein HJW98_RS03205 ENOG4108V08 YfdX protein HJW98_RS03210 ENOG4105BZU Histidine kinase HJW98_RS03215 ENOG4108WQH regulatoR HJW98_RS03235 ENOG4108VCA G U mismatch-specific DNA glycosylase HJW98_RS03240 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJW98_RS03245 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HJW98_RS03255 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HJW98_RS03265 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HJW98_RS03270 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HJW98_RS03275 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HJW98_RS03280 ENOG4105CQM Urea amidohydrolase subunit alpha HJW98_RS03285 ENOG4105KI2 Urea amidohydrolase subunit beta HJW98_RS03290 ENOG4108YZ9 Urea amidohydrolase subunit gamma HJW98_RS03295 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HJW98_RS03310 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HJW98_RS03315 ENOG4107ZVW dihydroneopterin aldolase HJW98_RS03320 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HJW98_RS03325 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HJW98_RS03330 ENOG4106MWK domain protein HJW98_RS03335 ENOG4105I7R Adenylate cyclase HJW98_RS03340 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HJW98_RS03345 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HJW98_RS03360 ENOG4105W0Z cytoplasmic protein HJW98_RS03375 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HJW98_RS03380 ENOG4106032 Glutathionylspermidine synthase HJW98_RS03385 ENOG4105F1G UPF0441 protein HJW98_RS03395 ENOG41087AY ADP-Ribose pyrophosphatase HJW98_RS03400 ENOG4108SX3 cytoplasmic protein HJW98_RS03405 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HJW98_RS03410 ENOG4105IPS esterase HJW98_RS03415 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW98_RS03420 ENOG4105VRH Antibiotic biosynthesis monooxygenase HJW98_RS03425 ENOG4105NF4 modulator of drug activity HJW98_RS03430 ENOG4105DHQ Histidine kinase HJW98_RS03435 ENOG4105XJC Two component transcriptional regulator (Winged helix family HJW98_RS03440 ENOG4105H4F exported protein HJW98_RS03445 ENOG4105F4I Transcriptional regulator HJW98_RS03450 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW98_RS03455 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HJW98_RS03460 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HJW98_RS03465 ENOG4105CCT upf0313 protein HJW98_RS03475 ENOG4105CV8 reductase HJW98_RS03480 ENOG4108I6A alcohol dehydrogenase HJW98_RS03485 ENOG4105CF7 AraC family transcriptional regulator HJW98_RS03490 ENOG4108K81 inner membrane protein YghB HJW98_RS03495 ENOG4105C28 cystathionine HJW98_RS03500 ENOG4105CWK Biopolymer transport protein, ExbB HJW98_RS03505 ENOG4108ZZF transport protein (ExbD) HJW98_RS03510 ENOG4105CT4 transporter HJW98_RS03515 ENOG4105E4I Glycoside hydrolase family 28 HJW98_RS03520 ENOG4108TEB UPF0114 protein HJW98_RS03530 ENOG410900S Protein of unknown function (DUF2623) HJW98_RS03535 ENOG4105CYM Glutathione S-transferase HJW98_RS03550 ENOG4106032 Glutathionylspermidine synthase HJW98_RS03555 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW98_RS03575 ENOG4105CC0 LysR family Transcriptional regulator HJW98_RS03580 ENOG4105C28 cystathionine HJW98_RS03595 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HJW98_RS03610 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HJW98_RS03615 ENOG4108VCD Chaperone HJW98_RS03620 ENOG4105CW0 outer membrane usher protein HJW98_RS03645 ENOG4108UQV Membrane HJW98_RS03650 ENOG4105CXN decarboxylase HJW98_RS03655 ENOG4105EAA nucleoside HJW98_RS03660 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HJW98_RS03665 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HJW98_RS03670 ENOG4105CEN a g-specific adenine glycosylase HJW98_RS03675 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HJW98_RS03680 ENOG41090ED Protein with unknown function (DUF469) HJW98_RS03685 ENOG4105K33 Periplasmic Protein HJW98_RS03690 ENOG4108HWW ABC transporter HJW98_RS03695 ENOG4105C2J ABC transporter HJW98_RS03705 ENOG4105CSA Coproporphyrinogen iii oxidase HJW98_RS03710 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HJW98_RS03715 ENOG4105VZ9 UPF0235 protein HJW98_RS03720 ENOG4108VIA integral membrane protein HJW98_RS03725 ENOG4105DFA alanine racemase domain protein HJW98_RS03730 ENOG4105CZX twitching motility protein HJW98_RS03740 ENOG41086KC Transcriptional regulator HJW98_RS03745 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HJW98_RS03750 ENOG4108UJU UPF0301 protein HJW98_RS03755 ENOG4105D7Z glutathione synthase HJW98_RS03760 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HJW98_RS03765 ENOG4105RWS endonuclease I HJW98_RS03770 ENOG4105GPY SprT protein HJW98_RS03775 ENOG4107QNK )-transporter HJW98_RS03780 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HJW98_RS03800 ENOG4105CYW agmatinase HJW98_RS03825 ENOG4105CHR reductase HJW98_RS03830 ENOG4108FUF Transcriptional regulator, IclR family HJW98_RS03860 ENOG4105CHR reductase HJW98_RS03865 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HJW98_RS03880 ENOG4105J5J Outer membrane porin HJW98_RS03885 ENOG4108K0D peptidase, M48 HJW98_RS03890 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJW98_RS03895 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJW98_RS03905 ENOG4105D2N Aldolase HJW98_RS03910 ENOG4105D64 Mechanosensitive ion channel HJW98_RS03915 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HJW98_RS03920 ENOG4105MPN Membrane HJW98_RS03925 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HJW98_RS03930 ENOG4105E66 phosphoriboisomerase A HJW98_RS03940 ENOG4108JQ1 Dehydrogenase HJW98_RS03945 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HJW98_RS03955 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HJW98_RS03960 ENOG4105E07 UPF0149 protein HJW98_RS03965 ENOG4107RAQ aminopeptidase HJW98_RS03970 ENOG4105D0A hydroxylase HJW98_RS03975 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HJW98_RS03980 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HJW98_RS03985 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HJW98_RS03990 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HJW98_RS03995 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HJW98_RS04000 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HJW98_RS04020 ENOG4105CS2 ec 3.2.1.21 HJW98_RS04025 ENOG4108Q3X Transcriptional regulator HJW98_RS04030 ENOG4105N5Z UPF0267 protein HJW98_RS04035 ENOG4108UT2 hemolysin iii HJW98_RS04045 ENOG4105Y75 tpr repeat protein HJW98_RS04050 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HJW98_RS04055 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HJW98_RS04060 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJW98_RS04065 ENOG4105T95 Thiol disulfide interChange protein HJW98_RS04070 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HJW98_RS04080 ENOG4105CRK lysyL-tRNA synthetase HJW98_RS04085 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HJW98_RS04095 ENOG4108K5P (LipO)protein HJW98_RS04115 ENOG4108WQH regulatoR HJW98_RS04120 ENOG4105BZU Histidine kinase HJW98_RS04140 ENOG4105CXC rtn protein HJW98_RS04155 ENOG4105CPC Aldo Keto reductase HJW98_RS04170 ENOG4105W7K Transcriptional regulator HJW98_RS04195 ENOG4107R5R arsenical pump membrane protein HJW98_RS04200 ENOG4105K89 arsenate reductase HJW98_RS04205 ENOG4105DUX Transporter HJW98_RS04210 ENOG4105V2F Uncharacterized protein yoac HJW98_RS04215 ENOG4105ETP RND efflux system, outer membrane lipoprotein HJW98_RS04220 ENOG4108MI0 Resistance protein HJW98_RS04225 ENOG4105J12 Multidrug resistance protein mdtN HJW98_RS04235 ENOG4105VR1 Pfam:DUF1271 HJW98_RS04240 ENOG410830R acetyltransferase HJW98_RS04250 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HJW98_RS04255 ENOG4108T65 Fimbrial HJW98_RS04260 ENOG4108SQA Fimbrial HJW98_RS04265 ENOG4105CW0 outer membrane usher protein HJW98_RS04270 ENOG4108NAE Fimbrial chaperone protein HJW98_RS04275 ENOG4108S54 Fimbrial protein HJW98_RS04280 ENOG4108RQP Major type 1 subunit fimbrin HJW98_RS04290 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HJW98_RS04295 ENOG4108W9T type 1 fimbriae regulatory protein HJW98_RS04300 ENOG4105D7X high-affinity nickel-transporter HJW98_RS04305 ENOG4108ZT1 Transcriptional regulator HJW98_RS04310 ENOG4108KTG Membrane protein, drug metabolite transporter HJW98_RS04320 ENOG4108T1W Fimbrial subunit type 3 HJW98_RS04360 ENOG4107S5I aldo keto reductase HJW98_RS04365 ENOG4108MHD transport protein HJW98_RS04375 ENOG4105C5Q Transcriptional regulator HJW98_RS04380 ENOG4105CHU acetyl-coa acetyltransferase HJW98_RS04385 ENOG4108QGT oligogalacturonate-specific porin HJW98_RS04390 ENOG4105CAZ oligogalacturonide lyase HJW98_RS04400 ENOG4105CHR reductase HJW98_RS04405 ENOG4107QNK )-transporter HJW98_RS04410 ENOG4106NDP Transcriptional regulator HJW98_RS04420 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW98_RS04425 ENOG4108HKT sucrose-6-phosphate hydrolase HJW98_RS04440 ENOG4108IJ9 (ABC) transporter HJW98_RS04445 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HJW98_RS04450 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HJW98_RS04455 ENOG4105YKW HJW98_RS04465 ENOG4105RQF LysR family Transcriptional regulator HJW98_RS04475 ENOG4105DDV Transcriptional regulator (LacI family HJW98_RS04480 ENOG4105CK1 PTS System HJW98_RS04485 ENOG4105CS2 ec 3.2.1.21 HJW98_RS04490 ENOG4107YCY Transcriptional regulator HJW98_RS04500 ENOG41060NJ transcriptional regulator HJW98_RS04505 ENOG4105CEY Amp-dependent synthetase and ligase HJW98_RS04510 ENOG4107S74 Lysophospholipid transporter LplT HJW98_RS04515 ENOG4105CPC Aldo Keto reductase HJW98_RS04520 ENOG4105SUV lipoprotein YgdR HJW98_RS04525 ENOG4105EE5 Membrane protein terC HJW98_RS04530 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HJW98_RS04540 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HJW98_RS04545 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HJW98_RS04550 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HJW98_RS04555 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HJW98_RS04560 ENOG4105IPU prepilin peptidase dependent protein A HJW98_RS04565 ENOG4105JCS prepilin peptidase dependent protein HJW98_RS04570 ENOG4105SEN Protein of unknown function (DUF2509) HJW98_RS04575 ENOG4105RVB Prepilin peptidase dependent protein c HJW98_RS04580 ENOG4105DSY exodeoxyribonuclease V, gamma HJW98_RS04585 ENOG4107QXK peptidase HJW98_RS04590 ENOG4107QKA exodeoxyribonuclease V beta HJW98_RS04595 ENOG4107QYX exodeoxyribonuclease v alpha HJW98_RS04605 ENOG4107QZM n-acetylglutamate synthase HJW98_RS04610 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HJW98_RS04615 ENOG4107QZB decarboxylase HJW98_RS04620 ENOG4105JZC GHMP kinase HJW98_RS04625 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HJW98_RS04630 ENOG4105KTW ethanolamine utilization protein HJW98_RS04635 ENOG4105M3W utilization protein HJW98_RS04645 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HJW98_RS04650 ENOG4105C0A alcohol dehydrogenase HJW98_RS04655 ENOG4108EKI Dehydrogenase HJW98_RS04665 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HJW98_RS04680 ENOG4105KNY Microcompartments protein HJW98_RS04685 ENOG4105KNY Microcompartments protein HJW98_RS04695 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HJW98_RS04700 ENOG4108ZFT Dehydratase small subunit HJW98_RS04705 ENOG4105YCI dehydratase medium subunit HJW98_RS04710 ENOG4105DMB glycerol dehydratase HJW98_RS04715 ENOG4105EHR propanediol utilization protein pduB HJW98_RS04720 ENOG4105KNY Microcompartments protein HJW98_RS04725 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJW98_RS04730 ENOG4107XVH Transcriptional regulator HJW98_RS04735 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HJW98_RS04740 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HJW98_RS04745 ENOG41081F0 Precorrin-8x methylmutase HJW98_RS04750 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HJW98_RS04755 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HJW98_RS04760 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HJW98_RS04765 ENOG4105CIA precorrin-4 C(11)-methyltransferase HJW98_RS04770 ENOG4108P62 biosynthesis protein (CbiG) HJW98_RS04775 ENOG4105E4R Precorrin-3B C17-methyltransferase HJW98_RS04780 ENOG4105QUC reductase HJW98_RS04785 ENOG4107PPM cobalt chelatase HJW98_RS04790 ENOG4105DVK Precorrin-2 c20-methyltransferase HJW98_RS04795 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HJW98_RS04800 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HJW98_RS04805 ENOG4108V4M Cobalt abc transporter HJW98_RS04815 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HJW98_RS04820 ENOG4108YZT Adenosylcobinamide kinase HJW98_RS04840 ENOG4105CA3 membrane-bound lytic murein transglycosylase HJW98_RS04845 ENOG4105CUZ uba thif-type nad fad binding protein HJW98_RS04850 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HJW98_RS04855 ENOG4105C9B Cysteine desulfurase HJW98_RS04860 ENOG4105M5B (LipO)protein HJW98_RS04865 ENOG4105ETT transcriptional Regulator, LysR family HJW98_RS04870 ENOG4105M08 Membrane HJW98_RS04880 ENOG4107EDW L-fucose operon activator HJW98_RS04885 ENOG4105NWF RbsD or FucU transport HJW98_RS04890 ENOG4105CMG Carbohydrate kinase HJW98_RS04895 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HJW98_RS04900 ENOG4105EDR glucose galactose transporter HJW98_RS04910 ENOG4107W7X Aldolase HJW98_RS04915 ENOG4105C0A alcohol dehydrogenase HJW98_RS04920 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HJW98_RS04925 ENOG4108JU7 Transcriptional regulator HJW98_RS04935 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJW98_RS04950 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS04955 ENOG4108UMI ABC transporter, permease HJW98_RS04960 ENOG4105D01 (LipO)protein HJW98_RS04965 ENOG41079KZ Major Facilitator Superfamily HJW98_RS04975 ENOG4105GVF (ABC) transporter HJW98_RS04980 ENOG4105EJQ L-serine dehydratase HJW98_RS04985 ENOG4105C44 Serine transporter HJW98_RS04990 ENOG4105EWT decarboxylase family HJW98_RS04995 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HJW98_RS05000 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HJW98_RS05005 ENOG4105WP7 tRNA pseudouridine synthase C HJW98_RS05010 ENOG4105DR9 pseudouridine synthase HJW98_RS05015 ENOG4105QDK Flavodoxin HJW98_RS05020 ENOG4105DJB Major Facilitator Superfamily HJW98_RS05025 ENOG4105EQX glucarate dehydratase HJW98_RS05030 ENOG4105EQX glucarate dehydratase HJW98_RS05035 ENOG4105BZW Glycerate kinase HJW98_RS05040 ENOG4105BZU Histidine kinase HJW98_RS05045 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HJW98_RS05050 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HJW98_RS05055 ENOG4105DXN mazG family HJW98_RS05060 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HJW98_RS05065 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HJW98_RS05080 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HJW98_RS05085 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HJW98_RS05090 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HJW98_RS05095 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HJW98_RS05100 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HJW98_RS05105 ENOG4108MXK alkaline phosphatase isozyme conversion HJW98_RS05110 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HJW98_RS05115 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HJW98_RS05125 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HJW98_RS05130 ENOG4105N0Z inner membrane protein ygbE HJW98_RS05135 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HJW98_RS05140 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HJW98_RS05145 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HJW98_RS05150 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HJW98_RS05160 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HJW98_RS05165 ENOG4108K5P (LipO)protein HJW98_RS05170 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJW98_RS05195 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HJW98_RS05200 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJW98_RS05205 ENOG4105KZM cytoplasmic protein HJW98_RS05215 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HJW98_RS05220 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS05225 ENOG4105EHG Permease protein HJW98_RS05230 ENOG4107R4I Periplasmic binding protein HJW98_RS05235 ENOG4106QJH hemin transport protein HJW98_RS05255 ENOG4108N2Y auxin Efflux HJW98_RS05265 ENOG4105VXR cytoplasmic protein HJW98_RS05270 ENOG4105CC5 ABC transporter HJW98_RS05275 ENOG4105CC5 ABC transporter HJW98_RS05280 ENOG4105DIK (ABC) transporter HJW98_RS05290 ENOG4105DDV Transcriptional regulator (LacI family HJW98_RS05295 ENOG4105DKQ ROK family HJW98_RS05300 ENOG4105VCP PTS System HJW98_RS05305 ENOG4105CK1 PTS System HJW98_RS05310 ENOG4105VZJ PTS System HJW98_RS05315 ENOG4105CK1 PTS System HJW98_RS05320 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW98_RS05330 ENOG4105CS2 ec 3.2.1.21 HJW98_RS05340 ENOG4105C45 hydrogenase expression formation protein (HypE) HJW98_RS05345 ENOG4105CQS hydrogenase expression formation protein HypD HJW98_RS05350 ENOG41083WG hydrogenase assembly chaperone HJW98_RS05355 ENOG4107RSS Hydrogenase accessory protein HypB HJW98_RS05360 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HJW98_RS05365 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HJW98_RS05370 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HJW98_RS05375 ENOG4107R30 NADH dehydrogenase HJW98_RS05380 ENOG4107TDF Formate hydrogenlyase subunit 4 HJW98_RS05385 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW98_RS05390 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HJW98_RS05395 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HJW98_RS05400 ENOG4105I6X formate hydrogenlyase maturation HJW98_RS05405 ENOG4108MG9 hydrogenase 3 maturation protease HJW98_RS05415 ENOG4105CS2 ec 3.2.1.21 HJW98_RS05420 ENOG4105C5Y PTS System HJW98_RS05430 ENOG4105DDV Transcriptional regulator (LacI family HJW98_RS05435 ENOG4108RC0 Electron transport protein HJW98_RS05440 ENOG4105C8H hydrogenase maturation protein Hypf HJW98_RS05450 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HJW98_RS05455 ENOG4105CNW domain protein HJW98_RS05465 ENOG4108JUA Transcriptional regulator HJW98_RS05475 ENOG410804X Transcriptional regulator HJW98_RS05480 ENOG4105J92 DNA-binding transcriptional activator GutM HJW98_RS05485 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HJW98_RS05490 ENOG4105VI0 Pts system, glucitol sorbitol-specific HJW98_RS05495 ENOG4105DZY Pts system, glucitol sorbitol-specific HJW98_RS05500 ENOG410787A Pts system, glucitol sorbitol-specific HJW98_RS05505 ENOG4105CVE Lytic murein transglycosylase HJW98_RS05515 ENOG4105CC5 ABC transporter HJW98_RS05525 ENOG4107TH8 cina domain protein HJW98_RS05530 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HJW98_RS05535 ENOG4105Y3E Modulates RecA activity (By similarity) HJW98_RS05540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HJW98_RS05545 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HJW98_RS05580 ENOG4105K3G Periplasmic Protein HJW98_RS05585 ENOG4107VXZ Hydrolase HJW98_RS05590 ENOG4105W39 Membrane HJW98_RS05595 ENOG4105D9M gamma-glutamylcysteine synthetase HJW98_RS05610 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HJW98_RS05615 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW98_RS05620 ENOG4105CW7 secretion protein, HlyD family HJW98_RS05630 ENOG4105NTK Transcriptional repressor Mpra HJW98_RS05640 ENOG4105ZED uncharacterized protein ygaH HJW98_RS05645 ENOG4108UMN azlc family HJW98_RS05650 ENOG4105GIJ Glycine betaine HJW98_RS05655 ENOG4108HQS Glycine betaine HJW98_RS05660 ENOG4108IJ7 Glycine betaine HJW98_RS05665 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW98_RS05670 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW98_RS05675 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HJW98_RS05680 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HJW98_RS05685 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HJW98_RS05690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW98_RS05695 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HJW98_RS05700 ENOG4108WMJ Protein of unknown function (DUF2002) HJW98_RS05705 ENOG4108RNS Exports L-alanine (By similarity) HJW98_RS05715 ENOG4108X73 DNA- binding protein HJW98_RS05730 ENOG4108V62 Rhodanese domain protein HJW98_RS05735 ENOG41080HT Transcriptional regulator, arsr family HJW98_RS05745 ENOG4105CC0 LysR family Transcriptional regulator HJW98_RS05750 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HJW98_RS05755 ENOG4105C26 Dehydrogenase HJW98_RS05760 ENOG4105X0I Fimbrial HJW98_RS05765 ENOG4108VCD Chaperone HJW98_RS05770 ENOG4105CW0 outer membrane usher protein HJW98_RS05785 ENOG4105CW0 outer membrane usher protein HJW98_RS05790 ENOG4106P2F Pfam:Pili_assembly_C HJW98_RS05795 ENOG4106EAR Fimbrial protein HJW98_RS05800 ENOG4108WQH regulatoR HJW98_RS05815 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HJW98_RS05820 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HJW98_RS05825 ENOG4105MP9 class II Aldolase HJW98_RS05835 ENOG4106TNF Periplasmic binding protein HJW98_RS05850 ENOG4105CYW agmatinase HJW98_RS05855 ENOG4105EVZ LysR family transcriptional regulator HJW98_RS05870 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW98_RS05875 ENOG4105UEI Transcriptional Regulator AraC Family HJW98_RS05895 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJW98_RS05930 ENOG4105KSC Transcriptional regulator, TraR DksA family HJW98_RS05935 ENOG4105DFE Dna adenine methylase HJW98_RS05970 ENOG4105ED4 portal protein HJW98_RS06120 ENOG4105ZTC transcriptional activator, Ogr delta HJW98_RS06135 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HJW98_RS06140 ENOG4108Z1B Cyclase dehydrase HJW98_RS06150 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJW98_RS06160 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HJW98_RS06165 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HJW98_RS06170 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HJW98_RS06175 ENOG4108JU6 CBS domain protein HJW98_RS06180 ENOG4106KVJ cytochrome C assembly protein HJW98_RS06185 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HJW98_RS06190 ENOG4105K5M 30s ribosomal protein S16 HJW98_RS06195 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HJW98_RS06200 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HJW98_RS06205 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HJW98_RS06225 ENOG41090EK ompa motb domain protein HJW98_RS06230 ENOG4108KHX Diguanylate cyclase HJW98_RS06235 ENOG4108WS1 HJW98_RS06240 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJW98_RS06245 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HJW98_RS06255 ENOG4105CQC Prephenate dehydratase HJW98_RS06265 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HJW98_RS06270 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJW98_RS06275 ENOG4105C34 Pseudouridine synthase HJW98_RS06280 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HJW98_RS06285 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJW98_RS06310 ENOG4105CSH Transporter HJW98_RS06315 ENOG4105T42 (LipO)protein HJW98_RS06320 ENOG4105JIM Phosphatidylserine synthase HJW98_RS06325 ENOG4105CD5 CoA-binding domain protein HJW98_RS06330 ENOG4106IUH DTW domain containing protein HJW98_RS06335 ENOG4105K63 Thioredoxin HJW98_RS06340 ENOG4105EIB trna rrna methyltransferase HJW98_RS06345 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HJW98_RS06350 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HJW98_RS06355 ENOG4105C1J atp-dependent rna helicase HJW98_RS06360 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HJW98_RS06365 ENOG4108IYU L-aspartate oxidase HJW98_RS06380 ENOG41069PW sigma-e factor negative regulatory protein HJW98_RS06385 ENOG4105VQK sigma E regulatory protein, MucB RseB HJW98_RS06390 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HJW98_RS06395 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HJW98_RS06400 ENOG4105C3F Signal peptidase i HJW98_RS06405 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HJW98_RS06410 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HJW98_RS06415 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HJW98_RS06420 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HJW98_RS06425 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HJW98_RS06430 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HJW98_RS06435 ENOG4106G6Q Transcriptional regulator HJW98_RS06440 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HJW98_RS06445 ENOG4108Z6B deaminase HJW98_RS06450 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HJW98_RS06455 ENOG4108ETH Formylglycinamide ribotide synthetase HJW98_RS06460 ENOG4107WP9 Histidine kinase HJW98_RS06465 ENOG4108SKK alpha helix protein HJW98_RS06470 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJW98_RS06475 ENOG4108YZA Nitrogen regulatory protein pii HJW98_RS06480 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJW98_RS06485 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HJW98_RS06490 ENOG4108SB3 DoxX Family HJW98_RS06500 ENOG41068P6 UPF0319 protein HJW98_RS06505 ENOG4106FKC arabinogalactan endo-1,4-beta-galactosidase HJW98_RS06510 ENOG4105FCK Membrane HJW98_RS06525 ENOG4108NZE NAGC-like transcriptional regulator HJW98_RS06530 ENOG4107HQ7 repeat protein HJW98_RS06535 ENOG4107QNK )-transporter HJW98_RS06540 ENOG4108ZKT aldose 1-epimerase HJW98_RS06545 ENOG4105D8G Major Facilitator superfamily HJW98_RS06550 ENOG4108MN2 Stationary phase inducible protein CsiE HJW98_RS06555 ENOG41065CD Exported protein HJW98_RS06560 ENOG4105D7X high-affinity nickel-transporter HJW98_RS06570 ENOG4105ECY inositol monophosphatase HJW98_RS06575 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HJW98_RS06580 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HJW98_RS06585 ENOG4105C3J Cysteine desulfurase HJW98_RS06590 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HJW98_RS06595 ENOG4108Z4V iron-sulfur cluster assembly HJW98_RS06600 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HJW98_RS06605 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HJW98_RS06610 ENOG4108ZIT Ferredoxin, 2FE-2S HJW98_RS06615 ENOG4105WVQ Fe-S assembly protein IscX HJW98_RS06620 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HJW98_RS06625 ENOG4105YYA enhanced serine sensitivity protein SseB HJW98_RS06635 ENOG4105KHC sulfurtransferase HJW98_RS06640 ENOG4105DN3 alpha-2-macroglobulin domain protein HJW98_RS06645 ENOG4108JQB penicillin-binding protein 1C HJW98_RS06650 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HJW98_RS06655 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HJW98_RS06660 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HJW98_RS06665 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HJW98_RS06675 ENOG4105N21 Membrane HJW98_RS06680 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJW98_RS06685 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HJW98_RS06705 ENOG4105VPD cellular component movement HJW98_RS06710 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HJW98_RS06715 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HJW98_RS06720 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HJW98_RS06725 ENOG4105CBG Sulfatase HJW98_RS06730 ENOG4105C4X radical SAM domain protein HJW98_RS06745 ENOG41062G3 Protein of unknown function (DUF2633) HJW98_RS06750 ENOG4105BZU Histidine kinase HJW98_RS06755 ENOG4105C9X ppx gppa phosphatase HJW98_RS06760 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HJW98_RS06765 ENOG4108V3E phosphoribosylglycinamide formyltransferase HJW98_RS06770 ENOG4105CXB phosphoribosylaminoimidazole synthetase HJW98_RS06775 ENOG41066F8 ROK family HJW98_RS06780 ENOG4105CS2 ec 3.2.1.21 HJW98_RS06785 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HJW98_RS06790 ENOG4105C2W permease HJW98_RS06795 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HJW98_RS06805 ENOG4105K89 arsenate reductase HJW98_RS06810 ENOG4105ERG peptidase m48, ste24p HJW98_RS06820 ENOG4105C02 permease HJW98_RS06825 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HJW98_RS06830 ENOG4105RH4 Glycine cleavage system transcriptional repressor HJW98_RS06835 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HJW98_RS06840 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJW98_RS06845 ENOG4105C8V SAICAR synthetase HJW98_RS06850 ENOG4105CGZ zinc metallopeptidase HJW98_RS06855 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HJW98_RS06860 ENOG4106KED esterase YpfH HJW98_RS06865 ENOG4105XYK UPF0370 protein HJW98_RS06870 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HJW98_RS06875 ENOG4105KUZ arsenate reductase HJW98_RS06885 ENOG4105BZS acriflavin resistance protein HJW98_RS06890 ENOG4105BZ8 glutamate synthase HJW98_RS06895 ENOG4107VIJ nudix hydrolase HJW98_RS06900 ENOG4108PVD exported protein HJW98_RS06905 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJW98_RS06910 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW98_RS06915 ENOG4105C6K Malic enzyme HJW98_RS06920 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HJW98_RS06925 ENOG4106S4J ethanolamine utilization protein EutP HJW98_RS06930 ENOG4105NDK ethanolamine utilization protein HJW98_RS06935 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HJW98_RS06940 ENOG4108IJ2 phosphate acetyltransferase HJW98_RS06945 ENOG4105KNY Microcompartments protein HJW98_RS06950 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HJW98_RS06955 ENOG4108EKI Dehydrogenase HJW98_RS06960 ENOG4107YMV ethanolamine utilization protein HJW98_RS06965 ENOG4105C0A alcohol dehydrogenase HJW98_RS06970 ENOG4105ENY Ethanolamine utilization protein eutH HJW98_RS06975 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HJW98_RS06980 ENOG4105CPD ethanolamine ammonia-lyase HJW98_RS06990 ENOG4106D67 ethanolamine utilization protein HJW98_RS06995 ENOG4108X49 Ethanolamine utilization protein EutK HJW98_RS07000 ENOG4108K3Z AraC family transcriptional regulator HJW98_RS07005 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HJW98_RS07010 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HJW98_RS07015 ENOG4108R6G acetyltransferase HJW98_RS07020 ENOG4105QZU Inner membrane protein YfeZ HJW98_RS07025 ENOG4105E7K (LipO)protein HJW98_RS07030 ENOG4105EZR dyp-type peroxidase family protein HJW98_RS07040 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HJW98_RS07045 ENOG4108I5D sulfate abc transporter HJW98_RS07050 ENOG4105ECW sulfate abc transporter HJW98_RS07055 ENOG4108IJ6 ABC transporter HJW98_RS07060 ENOG4105C6T cysteine synthase HJW98_RS07065 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HJW98_RS07070 ENOG4105CSW GntR family transcriptional regulator HJW98_RS07075 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HJW98_RS07085 ENOG4105C5Y PTS System HJW98_RS07090 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HJW98_RS07095 ENOG4105KZ7 phosphocarrier protein hpr HJW98_RS07105 ENOG4105C6T cysteine synthase HJW98_RS07110 ENOG4105EXN Sulfate transport protein CysZ HJW98_RS07115 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HJW98_RS07120 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HJW98_RS07125 ENOG4105VRT cytoplasmic protein HJW98_RS07130 ENOG4105DHU Bile acid HJW98_RS07135 ENOG4108M0I Transcriptional regulator HJW98_RS07165 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HJW98_RS07170 ENOG4105GXM Putative transcription regulator (DUF1323) HJW98_RS07175 ENOG4105HZG regulatoR HJW98_RS07190 ENOG4108KMM Diguanylate cyclase HJW98_RS07195 ENOG4105D9N nucleoside HJW98_RS07200 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HJW98_RS07205 ENOG4109076 Conserved Protein HJW98_RS07210 ENOG4105CPC Aldo Keto reductase HJW98_RS07215 ENOG4107RA9 decarboxylase HJW98_RS07225 ENOG4105CHC glucokinase (EC 2.7.1.2) HJW98_RS07230 ENOG4105DY9 regulatoR HJW98_RS07235 ENOG4108HRK Histidine kinase HJW98_RS07250 ENOG4105CHM Aminotransferase HJW98_RS07260 ENOG4105DJ2 Major Facilitator Superfamily HJW98_RS07265 ENOG4107Y2X deaminase HJW98_RS07270 ENOG4105DND Transcriptional regulator HJW98_RS07290 ENOG4105S64 Formate nitrite transporter HJW98_RS07295 ENOG410903C (LipO)protein HJW98_RS07300 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HJW98_RS07305 ENOG4105KZW UPF0381 protein HJW98_RS07310 ENOG4105CHU acetyl-coa acetyltransferase HJW98_RS07315 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HJW98_RS07320 ENOG4108BY2 phosphohistidine phosphatase HJW98_RS07325 ENOG4108DG9 Smr protein MutS2 HJW98_RS07330 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HJW98_RS07335 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HJW98_RS07340 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HJW98_RS07345 ENOG4105EJ9 Membrane HJW98_RS07350 ENOG4108BPE -transporting atpase HJW98_RS07355 ENOG4105MH2 YfcL protein HJW98_RS07360 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HJW98_RS07365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJW98_RS07370 ENOG4105F9N Major Facilitator Superfamily HJW98_RS07375 ENOG4106WZ1 flagella biosynthesis regulator HJW98_RS07385 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJW98_RS07390 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HJW98_RS07395 ENOG4105DQR SNARE associated Golgi HJW98_RS07400 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HJW98_RS07405 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HJW98_RS07410 ENOG4108S3P Sporulation domain protein HJW98_RS07415 ENOG4105E96 Colicin v production protein HJW98_RS07420 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HJW98_RS07425 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HJW98_RS07435 ENOG4105E89 ABC transporter HJW98_RS07440 ENOG4105E89 ABC transporter HJW98_RS07445 ENOG4105DSP amino acid AbC transporter HJW98_RS07450 ENOG4106YG3 ABC transporter HJW98_RS07455 ENOG4108JEH abc transporter atp-binding protein HJW98_RS07460 ENOG4105KNA -acetyltransferase HJW98_RS07470 ENOG4105ECP epimerase HJW98_RS07475 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HJW98_RS07480 ENOG4105CYM Glutathione S-transferase HJW98_RS07485 ENOG4108SHQ Glutathione S-transferase HJW98_RS07490 ENOG4108RE9 Phosphodiesterase HJW98_RS07495 ENOG4105PTV Nudix Hydrolase HJW98_RS07500 ENOG4105C6K Malic enzyme HJW98_RS07505 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HJW98_RS07510 ENOG4105PQ6 UPF0208 membrane protein HJW98_RS07520 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HJW98_RS07525 ENOG4107QWE )-transporter HJW98_RS07530 ENOG4105DK2 UPF0207 protein HJW98_RS07535 ENOG4105CHM Aminotransferase HJW98_RS07540 ENOG4107NQ8 LysR family Transcriptional regulator HJW98_RS07550 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HJW98_RS07555 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW98_RS07560 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW98_RS07565 ENOG4105GKE subunit e HJW98_RS07570 ENOG4107QIZ NADH dehydrogenase HJW98_RS07575 ENOG4108IEH NADH dehydrogenase subunit g HJW98_RS07580 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HJW98_RS07590 ENOG4107UFS subunit j HJW98_RS07595 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW98_RS07600 ENOG4105D65 subunit l HJW98_RS07605 ENOG4105C8S subunit m HJW98_RS07610 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW98_RS07615 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HJW98_RS07620 ENOG4107YB6 acetyltransferase, (GNAT) family HJW98_RS07625 ENOG4105E4F Isochorismate synthase HJW98_RS07630 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HJW98_RS07635 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HJW98_RS07640 ENOG4108IPT Naphthoate synthase HJW98_RS07645 ENOG4105DNI Converts SHCHC to OSB (By similarity) HJW98_RS07650 ENOG4105CEY Amp-dependent synthetase and ligase HJW98_RS07660 ENOG4105DNE Transposase HJW98_RS07670 ENOG4108UII YfaZ family HJW98_RS07675 ENOG4108EWA cinA-like protein HJW98_RS07680 ENOG4107258 Transcriptional regulator HJW98_RS07685 ENOG4105CXK mandelate racemase muconate lactonizing HJW98_RS07690 ENOG4105CSP Major Facilitator Superfamily HJW98_RS07695 ENOG4105CNV Aldolase HJW98_RS07700 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HJW98_RS07705 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HJW98_RS07710 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HJW98_RS07715 ENOG4105CXY transporter HJW98_RS07720 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HJW98_RS07725 ENOG4105XPH Ferredoxin HJW98_RS07730 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW98_RS07735 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW98_RS07740 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HJW98_RS07745 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW98_RS07750 ENOG4105BZU Histidine kinase HJW98_RS07755 ENOG41068CG regulatoR HJW98_RS07760 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HJW98_RS07775 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJW98_RS07780 ENOG4105CF1 Alkylated DNA repair protein HJW98_RS07785 ENOG4105IBP Cyclic peptide transporter HJW98_RS07790 ENOG4105CJW magnesium transporter HJW98_RS07795 ENOG4105CHH sulfate transporter HJW98_RS07810 ENOG4105F4G Membrane HJW98_RS07820 ENOG4105E68 Sulfatase HJW98_RS07825 ENOG4105PAN UPF0352 protein HJW98_RS07830 ENOG4106V8H Nucleoid-associated protein HJW98_RS07835 ENOG4105N2W Transcriptional regulator HJW98_RS07840 ENOG4107VIJ nudix hydrolase HJW98_RS07855 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HJW98_RS07860 ENOG4105CFI type iii restriction protein res subunit HJW98_RS07865 ENOG4105I08 Pseudouridine synthase HJW98_RS07870 ENOG4105C2C drug resistance transporter, Bcr CflA HJW98_RS07875 ENOG4105HG6 HJW98_RS07880 ENOG4108JQ5 ABC transporter HJW98_RS07885 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HJW98_RS07890 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HJW98_RS07895 ENOG4105E43 Extracellular solute-binding protein, family 5 HJW98_RS07900 ENOG4105CXC rtn protein HJW98_RS07905 ENOG4107TT5 NLP P60 protein HJW98_RS07910 ENOG41076MN Phosphoesterase, PA-phosphatase related HJW98_RS07915 ENOG4105CKI cobalamin synthesis protein HJW98_RS07920 ENOG4105DEI Mannitol dehydrogenase HJW98_RS07925 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HJW98_RS07935 ENOG4105KRS Proteinase inhibitor HJW98_RS07950 ENOG4105S8Q sugar efflux transporter HJW98_RS07955 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HJW98_RS07960 ENOG4105DE4 1-phosphofructokinase HJW98_RS07965 ENOG4105DM4 PTS System HJW98_RS07970 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HJW98_RS07975 ENOG4105HMI Membrane HJW98_RS07980 ENOG4105DUM transcriptional regulator, lysR family HJW98_RS07985 ENOG4108IQI permease HJW98_RS07990 ENOG4105D05 Receptor HJW98_RS08000 ENOG4105EUJ GTP cyclohydrolase i HJW98_RS08005 ENOG4105DHF Membrane HJW98_RS08010 ENOG41060NJ transcriptional regulator HJW98_RS08020 ENOG4105C2J ABC transporter HJW98_RS08025 ENOG4107SDZ Galactoside transport system permease protein mglC HJW98_RS08030 ENOG4107GZ4 SanA protein HJW98_RS08035 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HJW98_RS08040 ENOG41067MG lrgb family HJW98_RS08045 ENOG4105VAW lrga family HJW98_RS08050 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HJW98_RS08055 ENOG4105TW1 Carbohydrate-selective porin OprB HJW98_RS08070 ENOG4105CS2 ec 3.2.1.21 HJW98_RS08080 ENOG4105KHU inner membrane protein YohD HJW98_RS08085 ENOG41069YE inner membrane protein yohC HJW98_RS08090 ENOG41061WM D-Alanyl-D-Alanine HJW98_RS08100 ENOG4105CXG d-lactate dehydrogenase HJW98_RS08105 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HJW98_RS08110 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HJW98_RS08115 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HJW98_RS08120 ENOG4108IJ8 ABC transporter HJW98_RS08125 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HJW98_RS08135 ENOG4108HRK Histidine kinase HJW98_RS08140 ENOG4108NEV two component transcriptional regulator, LytTR family HJW98_RS08145 ENOG4108W15 Protein of unknown function (DUF1456) HJW98_RS08150 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HJW98_RS08155 ENOG4105D1F ATP-binding protein HJW98_RS08165 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HJW98_RS08170 ENOG4105EJC lysr family transcriptional regulator HJW98_RS08175 ENOG4105C7N Xanthine uracil vitamin C permease HJW98_RS08180 ENOG4105CPN adenine deaminase HJW98_RS08185 ENOG4105DUM transcriptional regulator, lysR family HJW98_RS08190 ENOG4105EUZ Beta-lactamase domain protein HJW98_RS08205 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HJW98_RS08210 ENOG4105DWF phosphomethylpyrimidine kinase HJW98_RS08215 ENOG4105EIE fructose-bisphosphate aldolase HJW98_RS08220 ENOG4105IE8 Alpha-ketoglutarate permease HJW98_RS08245 ENOG4105DEI Mannitol dehydrogenase HJW98_RS08250 ENOG4105CMG Carbohydrate kinase HJW98_RS08255 ENOG4105IE8 Alpha-ketoglutarate permease HJW98_RS08260 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HJW98_RS08270 ENOG4105CFP Peptidase U32 HJW98_RS08275 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJW98_RS08280 ENOG4105EB3 Histidine kinase HJW98_RS08285 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW98_RS08290 ENOG4105BZS acriflavin resistance protein HJW98_RS08295 ENOG4105BZS acriflavin resistance protein HJW98_RS08300 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJW98_RS08305 ENOG4105CK2 sodium dicarboxylate symporter HJW98_RS08325 ENOG4105BZU Histidine kinase HJW98_RS08330 ENOG4105R8A Heat shock protein HJW98_RS08335 ENOG4105D03 DNA-3-methyladenine glycosylase II HJW98_RS08340 ENOG4105DBI uridine monophosphokinase HJW98_RS08345 ENOG4105DHP deoxycytidine triphosphate deaminase HJW98_RS08350 ENOG4108GAE asmA family HJW98_RS08355 ENOG4105EE5 Membrane protein terC HJW98_RS08360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HJW98_RS08365 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HJW98_RS08375 ENOG4108MRJ HJW98_RS08380 ENOG4105DAY polysaccharide export protein HJW98_RS08395 ENOG4105D3Q Sugar transferase HJW98_RS08410 ENOG41090RK glycosyl transferase HJW98_RS08420 ENOG4105K64 Glycosyl transferase, family 2 HJW98_RS08425 ENOG4105CG5 Glycosyl transferase (Group 1 HJW98_RS08445 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HJW98_RS08490 ENOG4105CPK Glycosyl transferase (Group 1 HJW98_RS08515 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HJW98_RS08520 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HJW98_RS08530 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HJW98_RS08535 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HJW98_RS08540 ENOG4105CIH Imidazole acetol-phosphate transaminase HJW98_RS08550 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HJW98_RS08560 ENOG4107SRH Nad-dependent epimerase dehydratase HJW98_RS08565 ENOG4105EQ1 Transcriptional regulator HJW98_RS08575 ENOG4105CUB amino acid HJW98_RS08585 ENOG4105YVS arsR family transcriptional regulator HJW98_RS08590 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HJW98_RS08595 ENOG4105CJB Exodeoxyribonuclease I HJW98_RS08600 ENOG4105DZ1 carboxypeptidase HJW98_RS08610 ENOG4105DR8 Membrane HJW98_RS08615 ENOG41090HJ UPF0265 protein HJW98_RS08620 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HJW98_RS08625 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HJW98_RS08630 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HJW98_RS08640 ENOG41090U3 tautomerase HJW98_RS08645 ENOG4105HEI LysR family (Transcriptional regulator HJW98_RS08650 ENOG4108KMH lipoate-protein ligase a HJW98_RS08655 ENOG4105CSH Transporter HJW98_RS08665 ENOG4105BZU Histidine kinase HJW98_RS08675 ENOG4108YS1 cytoplasmic protein HJW98_RS08680 ENOG4105YP6 Domain of unknown function (DUF1869) HJW98_RS08685 ENOG4105ETT transcriptional Regulator, LysR family HJW98_RS08700 ENOG4105BZU Histidine kinase HJW98_RS08725 ENOG4105UQX Mate efflux family protein HJW98_RS08735 ENOG4105FYV Amp nucleosidase HJW98_RS08755 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HJW98_RS08760 ENOG4108WUH Transcriptional regulator, TetR family HJW98_RS08765 ENOG4105EEQ Na H antiporter HJW98_RS08785 ENOG4107R11 Transcriptional regulator HJW98_RS08790 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW98_RS08805 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HJW98_RS08815 ENOG4105FCK Membrane HJW98_RS08825 ENOG4105Y0K Inner membrane protein YedR HJW98_RS08830 ENOG4105EST Metal Dependent Phosphohydrolase HJW98_RS08835 ENOG4105DVF Cytosine-specific methyltransferase HJW98_RS08840 ENOG41090BB DNA mismatch endonuclease (vsr) HJW98_RS08845 ENOG4105FDR Membrane HJW98_RS08850 ENOG4105CKW Inner membrane protein yedI HJW98_RS08860 ENOG4105YX3 cellular response to acidity HJW98_RS08875 ENOG4105JCU Inherit from NOG: (Lipo)protein HJW98_RS08880 ENOG4105E5K Alpha-amylase HJW98_RS08885 ENOG4105EAB amino acid AbC transporter HJW98_RS08890 ENOG4105K6H D-cysteine desulfhydrase HJW98_RS08895 ENOG4105E5Q amino acid AbC transporter HJW98_RS08900 ENOG4105CDA abc transporter atp-binding protein HJW98_RS08905 ENOG4105VJY transcriptional regulator HJW98_RS08910 ENOG4105XVG cytoplasmic protein HJW98_RS08915 ENOG4105WH1 Two component transcriptional regulator luxr family HJW98_RS08950 ENOG4106RHG Yeca family HJW98_RS08955 ENOG4105E0U tyrosine-specific transport protein HJW98_RS08960 ENOG4105VVZ metal-binding protein HJW98_RS08965 ENOG41090A1 ferritin HJW98_RS08980 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW98_RS08985 ENOG4105N4N Protein of unknown function (DUF2766) HJW98_RS09000 ENOG4108UEC Ferritin-like protein HJW98_RS09010 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HJW98_RS09020 ENOG4105CNN ABC, transporter HJW98_RS09030 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HJW98_RS09035 ENOG4108VA4 Universal stress protein HJW98_RS09040 ENOG4105CT4 transporter HJW98_RS09045 ENOG4105F5H Glycosyl Hydrolase Family 88 HJW98_RS09050 ENOG4105C75 arginyL-tRNA synthetase HJW98_RS09055 ENOG4106ZCM YecM protein HJW98_RS09060 ENOG4106N3A copper homeostasis protein cutc HJW98_RS09065 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HJW98_RS09070 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HJW98_RS09075 ENOG4105WJG Glutathione HJW98_RS09080 ENOG41081XQ Conserved Protein HJW98_RS09085 ENOG4105D3W isochorismatase HJW98_RS09090 ENOG4105C9M aspartyl-trna synthetase HJW98_RS09095 ENOG4108TIT dATP pyrophosphohydrolase HJW98_RS09100 ENOG4105CDY transcriptional regulatory protein HJW98_RS09105 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HJW98_RS09110 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HJW98_RS09115 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HJW98_RS09120 ENOG4105FAV ABC, transporter HJW98_RS09130 ENOG4105NXV High-affinity zinc uptake system protein HJW98_RS09135 ENOG4105DR5 peptidase HJW98_RS09140 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HJW98_RS09145 ENOG4105CA9 Pyruvate kinase HJW98_RS09150 ENOG4106KNT transcriptional regulator HJW98_RS09160 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HJW98_RS09165 ENOG4105C01 Dihydroxy-acid dehydratase HJW98_RS09170 ENOG4108UHU Aldolase HJW98_RS09180 ENOG4105X2V dna damage-inducible protein HJW98_RS09185 ENOG4108Q2J Inner membrane protein YebE HJW98_RS09190 ENOG4105CUG Oligopeptidase b HJW98_RS09195 ENOG4105UMD exodeoxyribonuclease X HJW98_RS09200 ENOG4105MPK DNA polymerase III subunit theta HJW98_RS09205 ENOG4105FXM Copper resistance protein HJW98_RS09210 ENOG4108PNC copper resistance HJW98_RS09215 ENOG4105NKT exported protein HJW98_RS09225 ENOG4108MJ5 VirK protein HJW98_RS09230 ENOG4108R1E Serine threonine protein phosphatase 1 HJW98_RS09235 ENOG4105UVW uncharacterized protein yebW HJW98_RS09240 ENOG4105WT8 Protein of unknown function (DUF1480) HJW98_RS09245 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HJW98_RS09250 ENOG4105DY2 Paraquat-inducible protein b HJW98_RS09255 ENOG4105H2K paraquat-inducible protein a HJW98_RS09260 ENOG4108ZGC gaf domain protein HJW98_RS09265 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HJW98_RS09270 ENOG4105CN1 protease HJW98_RS09275 ENOG4105D0M Protease HtpX homolog HJW98_RS09280 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW98_RS09285 ENOG4105J4Q Transcriptional regulator HJW98_RS09290 ENOG4105TIK HJW98_RS09300 ENOG4105Q3Y exported protein HJW98_RS09320 ENOG4105CJN penicillin-binding protein HJW98_RS09325 ENOG4105DHI Methyltransferase HJW98_RS09330 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HJW98_RS09335 ENOG4108NK4 UPF0266 membrane protein HJW98_RS09340 ENOG4105F3R pts system mannose fructose sorbose family iid HJW98_RS09345 ENOG4105ETZ PTS System HJW98_RS09350 ENOG4105DAS pts system HJW98_RS09355 ENOG4105EE5 Membrane protein terC HJW98_RS09360 ENOG4107XTP (EAL) domain protein HJW98_RS09370 ENOG4105EJQ L-serine dehydratase HJW98_RS09375 ENOG4105P8F nudix hydrolase HJW98_RS09385 ENOG4105X5C UPF0181 protein HJW98_RS09390 ENOG4105M4H endoribonuclease L-psp HJW98_RS09395 ENOG4105DVT helicase HJW98_RS09400 ENOG41072GX Peptidase M22 Glycoprotease HJW98_RS09405 ENOG4105Y4Z Outer Membrane Lipoprotein HJW98_RS09410 ENOG4105CEY Amp-dependent synthetase and ligase HJW98_RS09415 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HJW98_RS09420 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HJW98_RS09425 ENOG4107QMS site-determining protein HJW98_RS09430 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HJW98_RS09435 ENOG4105VNG YcgL domain-containing protein HJW98_RS09440 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HJW98_RS09445 ENOG4108ZZ3 UPF0260 protein HJW98_RS09455 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HJW98_RS09460 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HJW98_RS09465 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HJW98_RS09470 ENOG4105ED1 spovr family HJW98_RS09480 ENOG4105MWK D-amino acid dehydrogenase, small subunit HJW98_RS09490 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HJW98_RS09495 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HJW98_RS09500 ENOG4106JQ5 Transglycosylase SLT domain HJW98_RS09505 ENOG4105E0K tonB-dependent siderophore receptor HJW98_RS09565 ENOG410811B TRANSCRIPTIONal HJW98_RS09570 ENOG4105C7B Threonine dehydratase HJW98_RS09575 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HJW98_RS09585 ENOG4105C6N Formate acetyltransferase HJW98_RS09600 ENOG4105C32 Amino acid ABC transporter (Permease) HJW98_RS09605 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJW98_RS09610 ENOG4105C0Z ABC transporter HJW98_RS09615 ENOG4108IV0 ABC, transporter HJW98_RS09620 ENOG4107YNJ LysR family Transcriptional regulator HJW98_RS09640 ENOG4105CSH Transporter HJW98_RS09650 ENOG4105F04 LysR family Transcriptional regulator HJW98_RS09660 ENOG4105D3G Pseudouridine synthase HJW98_RS09665 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HJW98_RS09690 ENOG4108ZG0 Ompa motb domain protein HJW98_RS09700 ENOG4105CS6 Rhs element vgr protein HJW98_RS09725 ENOG4105E6M Sulphatase-modifying factor protein HJW98_RS09805 ENOG4105C3G gtp-binding protein HJW98_RS09810 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HJW98_RS09815 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HJW98_RS09825 ENOG4105CHH sulfate transporter HJW98_RS09830 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HJW98_RS09835 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HJW98_RS09840 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HJW98_RS09845 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HJW98_RS09850 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HJW98_RS09855 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HJW98_RS09860 ENOG4108YY7 Invasion gene expression up-regulator SirB HJW98_RS09865 ENOG41063JG Transcriptional regulator HJW98_RS09870 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HJW98_RS09875 ENOG4105EWV Sodium calcium exchanger membrane region HJW98_RS09880 ENOG4105WS7 Cation transport regulator HJW98_RS09885 ENOG4108NH8 Cation transport protein HJW98_RS09895 ENOG41090EX DsrE family HJW98_RS09910 ENOG4105I5W Transporter HJW98_RS09920 ENOG4105D7T ABC transporter HJW98_RS09925 ENOG4107QZF nitrite reductase NADPH large subunit HJW98_RS09935 ENOG4105ID0 Putative invasin HJW98_RS09940 ENOG4105WH1 Two component transcriptional regulator luxr family HJW98_RS09945 ENOG4105BZU Histidine kinase HJW98_RS09950 ENOG4105DQQ Major facilitator superfamily MFS_1 HJW98_RS09960 ENOG4105CRU nitrate reductase, alpha subunit HJW98_RS09965 ENOG4108IUE nitrate reductase beta subunit HJW98_RS09970 ENOG4105R3A Nitrate reductase HJW98_RS09975 ENOG41076YT nitrate reductase, gamma subunit HJW98_RS10015 ENOG4105CIY formyltetrahydrofolate deformylase HJW98_RS10025 ENOG4105D78 K07001 NTE family protein HJW98_RS10030 ENOG4105I93 response regulator HJW98_RS10035 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HJW98_RS10050 ENOG4107104 thymidine kinase HJW98_RS10055 ENOG4105C0A alcohol dehydrogenase HJW98_RS10065 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HJW98_RS10075 ENOG4108J59 Extracellular solute-binding protein, family 5 HJW98_RS10080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW98_RS10085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW98_RS10090 ENOG4105C3U ABC transporter HJW98_RS10095 ENOG4108JQ7 (ABC) transporter HJW98_RS10100 ENOG4105EYW Ion transport protein HJW98_RS10105 ENOG4108W5H UPF0263 protein HJW98_RS10110 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HJW98_RS10120 ENOG4108YYC ycei family HJW98_RS10130 ENOG4105K9H YciI-like protein HJW98_RS10135 ENOG410822N TonB family HJW98_RS10145 ENOG4105P10 Uncharacterized protein ydiZ HJW98_RS10150 ENOG4105DE4 1-phosphofructokinase HJW98_RS10155 ENOG4108NE3 Salt-induced outer membrane protein HJW98_RS10170 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HJW98_RS10175 ENOG41082NX 50s ribosomal protein l35 HJW98_RS10190 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HJW98_RS10195 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HJW98_RS10200 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HJW98_RS10210 ENOG4105MWK D-amino acid dehydrogenase, small subunit HJW98_RS10215 ENOG4105RQF LysR family Transcriptional regulator HJW98_RS10225 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HJW98_RS10230 ENOG4105D01 (LipO)protein HJW98_RS10235 ENOG4108V06 Glutathione peroxidase HJW98_RS10245 ENOG4108QBX (LipO)protein HJW98_RS10250 ENOG4105CNG UPF0061 protein HJW98_RS10260 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJW98_RS10275 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HJW98_RS10285 ENOG4105IPI Membrane HJW98_RS10290 ENOG4105CQB FAD linked oxidase domain protein HJW98_RS10295 ENOG4105KA0 thioesterase Superfamily protein HJW98_RS10300 ENOG4105Y3U Transglycosylase-associated protein HJW98_RS10315 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HJW98_RS10325 ENOG4105E0A ABC, transporter HJW98_RS10330 ENOG4105EHG Permease protein HJW98_RS10340 ENOG4106KR7 LysR family Transcriptional regulator HJW98_RS10365 ENOG4105DMF Dehydrogenase HJW98_RS10370 ENOG4105KBX Transcriptional regulator, TetR family HJW98_RS10390 ENOG4108Z4V iron-sulfur cluster assembly HJW98_RS10395 ENOG4105DIW FeS assembly protein SUFB HJW98_RS10400 ENOG4105C3K feS assembly ATPase SufC HJW98_RS10405 ENOG4105JRK feS assembly protein SufD HJW98_RS10410 ENOG4105C9B Cysteine desulfurase HJW98_RS10415 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HJW98_RS10420 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW98_RS10430 ENOG4105CA9 Pyruvate kinase HJW98_RS10445 ENOG4105RFR Protein of unknown function (DUF2767) HJW98_RS10460 ENOG4105DJB Major Facilitator Superfamily HJW98_RS10465 ENOG4105E2X shikimate dehydrogenase HJW98_RS10470 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HJW98_RS10475 ENOG4108W0P ABC transporter HJW98_RS10480 ENOG4105EHG Permease protein HJW98_RS10485 ENOG4105S10 periplasmic binding protein HJW98_RS10490 ENOG4108K2P TRANSCRIPTIONal HJW98_RS10495 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HJW98_RS10500 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) HJW98_RS10505 ENOG4107UB2 Alpha beta hydrolase fold HJW98_RS10510 ENOG4105IKQ hydratase HJW98_RS10515 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HJW98_RS10520 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HJW98_RS10525 ENOG4108SC4 )-transporter HJW98_RS10540 ENOG4108T2C cysteine dioxygenase type I HJW98_RS10545 ENOG4106KR7 LysR family Transcriptional regulator HJW98_RS10550 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJW98_RS10570 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HJW98_RS10575 ENOG4108IY8 ABC, transporter HJW98_RS10585 ENOG4105E0A ABC, transporter HJW98_RS10590 ENOG4105DQ5 transport system permease protein HJW98_RS10610 ENOG4106PMH Extracellular solute-binding protein family 3 HJW98_RS10615 ENOG4105DRP amino acid AbC transporter HJW98_RS10620 ENOG4105CDA abc transporter atp-binding protein HJW98_RS10625 ENOG4105KZM cytoplasmic protein HJW98_RS10635 ENOG41083G8 Multidrug resistance protein MdtM HJW98_RS10660 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HJW98_RS10665 ENOG4105DG4 malate L-lactate dehydrogenase HJW98_RS10675 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HJW98_RS10680 ENOG4107Z33 ABC transporter, permease HJW98_RS10715 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HJW98_RS10720 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HJW98_RS10725 ENOG41060IM Heme exporter protein HJW98_RS10735 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HJW98_RS10740 ENOG4105DA4 cytochrome c-type biogenesis protein HJW98_RS10745 ENOG4107QX9 Thiol disulfide interChange protein HJW98_RS10750 ENOG4105KWW Biogenesis protein HJW98_RS10765 ENOG4105E7U AraC family transcriptional regulator HJW98_RS10790 ENOG4105CHR reductase HJW98_RS10795 ENOG4105C7K acetolactate synthase HJW98_RS10810 ENOG4105DTD Dehydrogenase HJW98_RS10815 ENOG4105CY2 Citrate transporter HJW98_RS10820 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HJW98_RS10825 ENOG4105CHU acetyl-coa acetyltransferase HJW98_RS10830 ENOG4107QNJ CoA-transferase subunit B HJW98_RS10840 ENOG4106NZI LysR family Transcriptional regulator HJW98_RS10860 ENOG4105CQB FAD linked oxidase domain protein HJW98_RS10865 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HJW98_RS10885 ENOG4105KME endoribonuclease L-psp HJW98_RS10890 ENOG4107TTD cytosine deaminase HJW98_RS10900 ENOG4105EMY transcriptional regulator HJW98_RS10930 ENOG4105CXC rtn protein HJW98_RS10945 ENOG4105EB3 Histidine kinase HJW98_RS10950 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJW98_RS10955 ENOG4105BZS acriflavin resistance protein HJW98_RS10970 ENOG4105IE8 Alpha-ketoglutarate permease HJW98_RS10975 ENOG4107Z96 xylose isomerase HJW98_RS10985 ENOG4108RVA ribokinase HJW98_RS11015 ENOG4108JQ7 (ABC) transporter HJW98_RS11020 ENOG4105C3U ABC transporter HJW98_RS11045 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HJW98_RS11050 ENOG4105E98 transcriptional regulator DeoR family HJW98_RS11060 ENOG4107B2H carbonic anhydrase HJW98_RS11090 ENOG4105CY0 Metallo-Beta-Lactamase HJW98_RS11110 ENOG4107FW0 short-chain dehydrogenase reductase HJW98_RS11140 ENOG4108URH decarboxylase HJW98_RS11150 ENOG4107QI1 Mate efflux family protein HJW98_RS11155 ENOG4108R6K riboflavin synthase, subunit alpha HJW98_RS11160 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HJW98_RS11165 ENOG4105CZQ inner membrane transport protein YdhC HJW98_RS11170 ENOG4105F52 Transcriptional regulator HJW98_RS11175 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS11185 ENOG4105F27 Major Facilitator HJW98_RS11190 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJW98_RS11200 ENOG4105K4H Nlp p60 protein HJW98_RS11205 ENOG4105M2J Glutaredoxin HJW98_RS11210 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HJW98_RS11215 ENOG4108UYE Lactoylglutathione lyase HJW98_RS11220 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJW98_RS11225 ENOG4108WUH Transcriptional regulator, TetR family HJW98_RS11230 ENOG4105XZD Fe-S protein HJW98_RS11235 ENOG4107RGM aldo keto reductase HJW98_RS11240 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJW98_RS11245 ENOG4105DSW Fusaric acid resistance protein HJW98_RS11250 ENOG4105Y49 secretion protein, HlyD family HJW98_RS11265 ENOG4105BZU Histidine kinase HJW98_RS11270 ENOG4108XTF Outer Membrane Lipoprotein HJW98_RS11275 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HJW98_RS11280 ENOG410642K Lysozyme inhibitor HJW98_RS11285 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HJW98_RS11290 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HJW98_RS11295 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HJW98_RS11300 ENOG4108K3A Glutathione S-transferase HJW98_RS11310 ENOG4105CSM endonuclease III HJW98_RS11320 ENOG4108UQQ Electron transport complex HJW98_RS11345 ENOG4105M9B inner membrane protein ydgK HJW98_RS11355 ENOG4105CS2 ec 3.2.1.21 HJW98_RS11365 ENOG4105D9R oxidoreductase HJW98_RS11370 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HJW98_RS11375 ENOG4105EQ0 Major Facilitator superfamily HJW98_RS11395 ENOG4105CPW cytochrome b561 HJW98_RS11415 ENOG4105DDW LysR family Transcriptional regulator HJW98_RS11420 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HJW98_RS11425 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HJW98_RS11430 ENOG4105E32 cytoplasmic protein HJW98_RS11435 ENOG4105EBR Carboxylesterase HJW98_RS11450 ENOG4108Z9I -acetyltransferase HJW98_RS11455 ENOG4107WE3 acetyltransferase YdcK HJW98_RS11460 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HJW98_RS11465 ENOG41088CC tellurite resistance protein tehB HJW98_RS11470 ENOG4108KKZ (LipO)protein HJW98_RS11475 ENOG4105DWP Membrane HJW98_RS11480 ENOG4105UEI Transcriptional Regulator AraC Family HJW98_RS11485 ENOG4105DKK Benzoate HJW98_RS11490 ENOG4108JCI Transcriptional regulator HJW98_RS11500 ENOG4105CFP Peptidase U32 HJW98_RS11520 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJW98_RS11525 ENOG4105C4M (Ubiquinol oxidase) subunit I HJW98_RS11530 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW98_RS11535 ENOG4107TYH extracellular solute-binding protein family 1 HJW98_RS11540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS11545 ENOG4105D81 ABC transporter, permease HJW98_RS11550 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HJW98_RS11555 ENOG4105C26 Dehydrogenase HJW98_RS11580 ENOG410654E Membrane HJW98_RS11585 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HJW98_RS11600 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW98_RS11605 ENOG4105R71 cytoplasmic protein HJW98_RS11610 ENOG4108T9Y Inner membrane protein ydcZ HJW98_RS11615 ENOG4108Z7F N-acetyltransferase HJW98_RS11625 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HJW98_RS11630 ENOG4105DU0 nucleoside hydrolase HJW98_RS11640 ENOG41065TG regulatoR HJW98_RS11645 ENOG4105CPN adenine deaminase HJW98_RS11650 ENOG4105CHB tonB-dependent Receptor HJW98_RS11655 ENOG4108NS2 receptor HJW98_RS11665 ENOG4105C85 amino acid HJW98_RS11670 ENOG4105EQ2 LysR family Transcriptional regulator HJW98_RS11680 ENOG4105DEN Luciferase family HJW98_RS11695 ENOG4105EAB amino acid AbC transporter HJW98_RS11705 ENOG4105DRP amino acid AbC transporter HJW98_RS11710 ENOG4105CDA abc transporter atp-binding protein HJW98_RS11720 ENOG4108N27 Glutathione S-transferase HJW98_RS11725 ENOG4105KZK Tautomerase pptA HJW98_RS11730 ENOG4108MEJ flavin reductase domain protein HJW98_RS11735 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS11740 ENOG4105C4Y ABC transporter HJW98_RS11745 ENOG4107RCV ABC transporter, permease HJW98_RS11750 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HJW98_RS11755 ENOG4105D0D Nitrate reductase 2, gamma subunit HJW98_RS11760 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HJW98_RS11765 ENOG4108IUE nitrate reductase beta subunit HJW98_RS11770 ENOG4105CRU nitrate reductase, alpha subunit HJW98_RS11775 ENOG4107QND Nitrite extrusion protein HJW98_RS11790 ENOG4107HP6 Transcriptional regulator HJW98_RS11795 ENOG4105DTQ mandelate racemase muconate lactonizing HJW98_RS11800 ENOG4105NN7 muconolactone delta-isomerase HJW98_RS11805 ENOG410626B catechol 1,2-dioxygenase HJW98_RS11815 ENOG4108UKV benzoate 1,2-dioxygenase HJW98_RS11840 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HJW98_RS11845 ENOG4108MG3 formate dehydrogenase HJW98_RS11860 ENOG4105CSR polyphosphate kinase 2 HJW98_RS11870 ENOG4105F27 Major Facilitator HJW98_RS11885 ENOG4108JQ6 ABC transporter HJW98_RS11890 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW98_RS11905 ENOG4105DQ4 alcohol dehydrogenase HJW98_RS11920 ENOG4105C5H ABC transporter HJW98_RS11930 ENOG4107R1I NAD-dependent malic enzyme HJW98_RS11950 ENOG4105EQ2 LysR family Transcriptional regulator HJW98_RS11955 ENOG4105N0E Protein of unknown function (DUF2543) HJW98_RS11960 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HJW98_RS11975 ENOG4108N8X transition metal ion binding HJW98_RS11985 ENOG4105CG3 alpha amylase, catalytic region HJW98_RS12005 ENOG4108YDI single-species biofilm formation on inanimate substrate HJW98_RS12015 ENOG4108Z9K Osmotically inducible protein HJW98_RS12040 ENOG4105FFC UPF0187 protein HJW98_RS12045 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HJW98_RS12050 ENOG4105C5Q Transcriptional regulator HJW98_RS12055 ENOG4105CK1 PTS System HJW98_RS12080 ENOG4105VZJ PTS System HJW98_RS12085 ENOG4105VCP PTS System HJW98_RS12090 ENOG4108KUU Inner membrane metabolite transport protein ydjE HJW98_RS12095 ENOG4105KT7 mgtC SapB transporter HJW98_RS12100 ENOG4105D6Z AFG1 family ATPase HJW98_RS12105 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HJW98_RS12120 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HJW98_RS12125 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HJW98_RS12130 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HJW98_RS12140 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HJW98_RS12145 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HJW98_RS12155 ENOG4108IGT Dipeptidase HJW98_RS12160 ENOG4108J2P Alpha beta hydrolase fold HJW98_RS12170 ENOG4105E0F Histidine kinase HJW98_RS12185 ENOG4105DY8 decarboxylase HJW98_RS12190 ENOG4108JPW Aminotransferase HJW98_RS12195 ENOG4107Z6I Thiamine biosynthesis protein HJW98_RS12200 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HJW98_RS12205 ENOG4108YI8 ABC transporter HJW98_RS12210 ENOG4105ETU transcriptional activator (TenA HJW98_RS12225 ENOG4105CIB oxidoreductase Domain protein HJW98_RS12235 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS12240 ENOG4105BZU Histidine kinase HJW98_RS12245 ENOG4107QUY Guanine deaminase HJW98_RS12250 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HJW98_RS12285 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HJW98_RS12290 ENOG41089BK Glutamine amido-transferase HJW98_RS12295 ENOG4105R1U AraC Family Transcriptional Regulator HJW98_RS12320 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJW98_RS12345 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJW98_RS12370 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HJW98_RS12390 ENOG4105E5Q amino acid AbC transporter HJW98_RS12400 ENOG4105C5R Aminotransferase HJW98_RS12415 ENOG4105CBN LysR family transcriptional regulator HJW98_RS12425 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJW98_RS12430 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HJW98_RS12435 ENOG4105CSH Transporter HJW98_RS12480 ENOG4105FCD Major Facilitator HJW98_RS12490 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS12495 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HJW98_RS12505 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HJW98_RS12510 ENOG4105UP7 3-epimerase HJW98_RS12520 ENOG4108YRF PTS System HJW98_RS12525 ENOG4105DM4 PTS System HJW98_RS12530 ENOG410829K Lysine exporter protein (Lyse ygga) HJW98_RS12540 ENOG4105CBN LysR family transcriptional regulator HJW98_RS12545 ENOG4105HEI LysR family (Transcriptional regulator HJW98_RS12560 ENOG4107PP3 Acetylornithine deacetylase HJW98_RS12575 ENOG4105CNN ABC, transporter HJW98_RS12580 ENOG4105C2J ABC transporter HJW98_RS12585 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS12615 ENOG4109066 lysm domain bon superfamily protein HJW98_RS12620 ENOG4105CXY transporter HJW98_RS12625 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HJW98_RS12635 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HJW98_RS12640 ENOG4105RHY Pfam:UPF0157 HJW98_RS12645 ENOG4105EQ2 LysR family Transcriptional regulator HJW98_RS12650 ENOG4105CPC Aldo Keto reductase HJW98_RS12690 ENOG4105K63 Thioredoxin HJW98_RS12720 ENOG4105ETT transcriptional Regulator, LysR family HJW98_RS12730 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HJW98_RS12735 ENOG4105CHR reductase HJW98_RS12740 ENOG4105CHU acetyl-coa acetyltransferase HJW98_RS12760 ENOG4105BZW Glycerate kinase HJW98_RS12765 ENOG4107VHA regulatoR HJW98_RS12775 ENOG4105JQN Transcriptional regulator HJW98_RS12785 ENOG4107YCY Transcriptional regulator HJW98_RS12790 ENOG4105CI1 PTS System HJW98_RS12795 ENOG4105F8D glycoside hydrolase family 4 HJW98_RS12805 ENOG4105C54 Major Facilitator superfamily HJW98_RS12810 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HJW98_RS12830 ENOG4105NIV Esterase HJW98_RS12835 ENOG4105BZU Histidine kinase HJW98_RS12850 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HJW98_RS12865 ENOG4108VCD Chaperone HJW98_RS12870 ENOG4105CW0 outer membrane usher protein HJW98_RS12880 ENOG4105F32 YngK protein HJW98_RS12885 ENOG4105CAF HipA N-terminal domain protein HJW98_RS12890 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HJW98_RS12895 ENOG4105VT2 5-hydroxyisourate hydrolase HJW98_RS12900 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HJW98_RS12905 ENOG4105C2W permease HJW98_RS12910 ENOG41061H0 Monooxygenase HJW98_RS12915 ENOG4108KSA LysR family transcriptional regulator HJW98_RS12935 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HJW98_RS12950 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HJW98_RS12960 ENOG4105D01 (LipO)protein HJW98_RS12970 ENOG4108UMI ABC transporter, permease HJW98_RS12975 ENOG4105EA8 2-Nitropropane dioxygenase HJW98_RS12985 ENOG4105EGI Transcriptional regulator HJW98_RS13000 ENOG4105F9N Major Facilitator Superfamily HJW98_RS13045 ENOG4107QZW Altronate oxidoreductase HJW98_RS13055 ENOG4105BZU Histidine kinase HJW98_RS13060 ENOG4105M0C cytoplasmic protein HJW98_RS13065 ENOG4105CSV Glutaminase HJW98_RS13070 ENOG4105C26 Dehydrogenase HJW98_RS13075 ENOG4105EGI Transcriptional regulator HJW98_RS13090 ENOG4105MVE transcriptional regulator HJW98_RS13095 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HJW98_RS13100 ENOG4107S2N Type III effector Hrp-dependent HJW98_RS13105 ENOG4105C0A alcohol dehydrogenase HJW98_RS13110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HJW98_RS13115 ENOG4108JQ1 Dehydrogenase HJW98_RS13125 ENOG4105JAB phenazine biosynthesis protein, phzf family HJW98_RS13130 ENOG4105F27 Major Facilitator HJW98_RS13135 ENOG41082NP Multiple antibiotic resistance HJW98_RS13145 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HJW98_RS13150 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HJW98_RS13155 ENOG4106DNR multiple antibiotic resistance protein HJW98_RS13160 ENOG4108594 Permease of the drug metabolite transporter HJW98_RS13165 ENOG4105E5W Transporter HJW98_RS13175 ENOG4108IV0 ABC, transporter HJW98_RS13180 ENOG4105C0Z ABC transporter HJW98_RS13185 ENOG4105CNN ABC, transporter HJW98_RS13190 ENOG4105C32 Amino acid ABC transporter (Permease) HJW98_RS13210 ENOG4105ECQ AraC Family Transcriptional Regulator HJW98_RS13230 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS13235 ENOG4105CNT hydrolase family 2 HJW98_RS13240 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW98_RS13245 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HJW98_RS13255 ENOG4108J4B Beta-lactamase HJW98_RS13260 ENOG4105MVE transcriptional regulator HJW98_RS13270 ENOG4105G63 Type III effector Hrp-dependent HJW98_RS13275 ENOG4105FB2 class II Aldolase HJW98_RS13280 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HJW98_RS13285 ENOG4105C6Z Gluconate HJW98_RS13305 ENOG4105BZU Histidine kinase HJW98_RS13310 ENOG4108WTK competence damage-inducible protein HJW98_RS13315 ENOG4108ZNX Heat shock protein HJW98_RS13330 ENOG4108WQH regulatoR HJW98_RS13350 ENOG4105R1U AraC Family Transcriptional Regulator HJW98_RS13360 ENOG4105DGW oligopeptidase A HJW98_RS13365 ENOG4105EMU Dehydrogenase HJW98_RS13370 ENOG4107XBN GntR Family Transcriptional Regulator HJW98_RS13375 ENOG4108U51 Universal stress protein HJW98_RS13380 ENOG4105DEI Mannitol dehydrogenase HJW98_RS13385 ENOG4108I5G Major Facilitator superfamily HJW98_RS13390 ENOG4105KK4 UPF0060 membrane protein HJW98_RS13395 ENOG4105M5Q UPF0482 protein HJW98_RS13400 ENOG4108MK9 spermidine N(1)-acetyltransferase HJW98_RS13410 ENOG4105KBG Protein of unknown function (DUF1161) HJW98_RS13415 ENOG4107QY8 reductase HJW98_RS13420 ENOG4105QAX Iron-sulfur HJW98_RS13430 ENOG4108NEM leader-binding protein dmsD HJW98_RS13435 ENOG4105CMQ Chloride channel HJW98_RS13440 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HJW98_RS13445 ENOG4105DAG ROK family HJW98_RS13450 ENOG4106NZI LysR family Transcriptional regulator HJW98_RS13455 ENOG4105D94 Major Facilitator Superfamily HJW98_RS13460 ENOG4105CTD carboxy-peptidase HJW98_RS13480 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HJW98_RS13490 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HJW98_RS13495 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HJW98_RS13500 ENOG4105DSF transport protein HJW98_RS13530 ENOG4107TT2 Auxin Efflux Carrier HJW98_RS13535 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HJW98_RS13540 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HJW98_RS13545 ENOG4108K70 Transcriptional regulator HJW98_RS13550 ENOG4105DWT malate dehydrogenase (quinone) HJW98_RS13555 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HJW98_RS13565 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HJW98_RS13570 ENOG4108MRH transcriptional regulatory protein HJW98_RS13590 ENOG4107GFK fumarate HJW98_RS13600 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HJW98_RS13605 ENOG4105F2Z 3-oxoadipate enol-lactonase HJW98_RS13610 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HJW98_RS13615 ENOG4105CHU acetyl-coa acetyltransferase HJW98_RS13620 ENOG4107QNJ CoA-transferase subunit B HJW98_RS13630 ENOG4107HP6 Transcriptional regulator HJW98_RS13635 ENOG4108DG9 Smr protein MutS2 HJW98_RS13640 ENOG4106KR7 LysR family Transcriptional regulator HJW98_RS13650 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HJW98_RS13655 ENOG4105CFC Transporter HJW98_RS13665 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJW98_RS13670 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HJW98_RS13675 ENOG4105Q9Y Universal stress protein HJW98_RS13680 ENOG410671Z uncharacterized protein ydiH HJW98_RS13685 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HJW98_RS13690 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HJW98_RS13705 ENOG4105C5D exported protein HJW98_RS13710 ENOG4105D5Q Arginine ornithine antiporter HJW98_RS13715 ENOG410642E Short chain dehydrogenase HJW98_RS13720 ENOG4105RA2 Membrane HJW98_RS13725 ENOG4107EXC regulatoR HJW98_RS13735 ENOG4105JJR Histidine kinase HJW98_RS13745 ENOG4105C9Q fumarate hydratase class II HJW98_RS13750 ENOG4107GFK fumarate HJW98_RS13755 ENOG4105EIP mannose-6-phosphate isomerase HJW98_RS13760 ENOG4106J39 exported protein HJW98_RS13765 ENOG4107P2S Transcriptional regulator HJW98_RS13770 ENOG4105CI1 PTS System HJW98_RS13775 ENOG4105C87 Aminotransferase class I and II HJW98_RS13785 ENOG41061EV selenium-binding protein YdfZ HJW98_RS13800 ENOG41066VF YeeE YedE family protein HJW98_RS13810 ENOG41064WM Uncharacterized protein YcgX HJW98_RS13815 ENOG4105VPI YqaE family transport protein HJW98_RS13820 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJW98_RS13825 ENOG4105C26 Dehydrogenase HJW98_RS13835 ENOG4107DB1 DUF218 domain HJW98_RS13850 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HJW98_RS13855 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HJW98_RS13860 ENOG4105C26 Dehydrogenase HJW98_RS13865 ENOG4105F4X arginine HJW98_RS13870 ENOG4105C8Y Acetylornithine aminotransferase HJW98_RS13885 ENOG4105D82 Glutamate dehydrogenase HJW98_RS13890 ENOG4108FN7 Aldo keto reductase HJW98_RS13895 ENOG410642W LysR family Transcriptional regulator HJW98_RS13915 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJW98_RS13925 ENOG4105CQ7 ATP-dependent helicase HJW98_RS13930 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HJW98_RS13940 ENOG4108Z0R Transferase HJW98_RS13945 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HJW98_RS13950 ENOG4105DZS Phenylacetate-CoA ligase HJW98_RS13955 ENOG4105CHU acetyl-coa acetyltransferase HJW98_RS13960 ENOG4108ZJI phenylacetic acid degradation protein HJW98_RS13965 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HJW98_RS13970 ENOG4108UKI Enoyl-CoA hydratase HJW98_RS13975 ENOG4105E39 Enoyl-CoA hydratase HJW98_RS13980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJW98_RS13985 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HJW98_RS13990 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HJW98_RS13995 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HJW98_RS14000 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HJW98_RS14005 ENOG4105DXM phenylacetic acid degradation protein HJW98_RS14010 ENOG4105F11 amine oxidase HJW98_RS14025 ENOG4105C26 Dehydrogenase HJW98_RS14030 ENOG4108WFR AraC Family Transcriptional Regulator HJW98_RS14035 ENOG4105WXT Conserved Protein HJW98_RS14040 ENOG410689M (LipO)protein HJW98_RS14045 ENOG4107H52 Dicarboxylate transport HJW98_RS14050 ENOG4108KF1 Membrane HJW98_RS14055 ENOG4105C5I Dehydrogenase HJW98_RS14060 ENOG41090X5 Heat shock protein hslJ HJW98_RS14065 ENOG4105IKK cytoplasmic protein HJW98_RS14070 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HJW98_RS14075 ENOG4105FCK Membrane HJW98_RS14085 ENOG4108RW8 Universal stress protein F HJW98_RS14095 ENOG4105C1J atp-dependent rna helicase HJW98_RS14100 ENOG4107RX3 Mg2 transporter protein cora family protein HJW98_RS14105 ENOG4105E98 transcriptional regulator DeoR family HJW98_RS14110 ENOG4105D9R oxidoreductase HJW98_RS14125 ENOG4108UMI ABC transporter, permease HJW98_RS14135 ENOG4105D01 (LipO)protein HJW98_RS14175 ENOG4105HEI LysR family (Transcriptional regulator HJW98_RS14200 ENOG4108XFH Transcriptional regulator HJW98_RS14205 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HJW98_RS14295 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJW98_RS14305 ENOG4108ZG0 Ompa motb domain protein HJW98_RS14335 ENOG4108Z0Z intracellular protease Pfpi family HJW98_RS14350 ENOG4105CBN LysR family transcriptional regulator HJW98_RS14410 ENOG4105BZU Histidine kinase HJW98_RS14425 ENOG4107RTG Major Facilitator superfamily HJW98_RS14430 ENOG4105ENX hydrolase HJW98_RS14435 ENOG4105EQ2 LysR family Transcriptional regulator HJW98_RS14450 ENOG4107QSI ABC, transporter HJW98_RS14460 ENOG4105KXI murein peptide amidase A HJW98_RS14465 ENOG4107S8C mandelate racemase muconate lactonizing HJW98_RS14470 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HJW98_RS14475 ENOG4108KK1 membrane protein AbrB duplication HJW98_RS14480 ENOG4108JU8 Transcriptional regulator HJW98_RS14485 ENOG4105F8D glycoside hydrolase family 4 HJW98_RS14490 ENOG4105W8I Transcriptional regulator HJW98_RS14495 ENOG4106K28 UPF0283 membrane protein HJW98_RS14500 ENOG4105CM6 amino acid regulated cytosolic protein HJW98_RS14505 ENOG4105NNG Peripheral inner membrane phage-shock protein HJW98_RS14510 ENOG4105FM1 phage shock protein C HJW98_RS14515 ENOG4105YYT phage shock protein B HJW98_RS14520 ENOG41087YS Phage shock protein A HJW98_RS14525 ENOG4105E51 psp operon transcriptional activator HJW98_RS14535 ENOG4105CH2 amidohydrolase HJW98_RS14540 ENOG41063ZK Transcriptional Regulator AraC Family HJW98_RS14555 ENOG4108J59 Extracellular solute-binding protein, family 5 HJW98_RS14560 ENOG4108EKA peptide transport system, permease HJW98_RS14605 ENOG4105RWQ Protein of unknown function (DUF1364) HJW98_RS14660 ENOG4105JBR DNA replication protein HJW98_RS14710 ENOG4105UVW uncharacterized protein yebW HJW98_RS14720 ENOG41076J9 exonuclease VIII HJW98_RS14755 ENOG4108EU3 peptide transport system, permease HJW98_RS14760 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HJW98_RS14765 ENOG4108JQ2 peptide transport system atp-binding protein HJW98_RS14770 ENOG4105ETS cytosine purines uracil thiamine allantoin HJW98_RS14780 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HJW98_RS14785 ENOG4105Q4T oxidoreductase HJW98_RS14790 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HJW98_RS14800 ENOG4105N2W Transcriptional regulator HJW98_RS14810 ENOG41061RM osmotically inducible lipoprotein HJW98_RS14815 ENOG4108ZJT translation initiation factor, Sui1 HJW98_RS14825 ENOG4105CFV Tetratricopeptide repeat protein HJW98_RS14830 ENOG4105Q4A inner membrane protein yciS HJW98_RS14835 ENOG4105EYK Phosphatidylglycerophosphatase B HJW98_RS14840 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HJW98_RS14845 ENOG4107QM5 aconitate hydratase HJW98_RS14855 ENOG4107R11 Transcriptional regulator HJW98_RS14860 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HJW98_RS14865 ENOG4105RKX Protein of unknown function (DUF2498) HJW98_RS14870 ENOG4105ERU peptidase HJW98_RS14880 ENOG4105UBK short-chain dehydrogenase reductase HJW98_RS14885 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HJW98_RS14910 ENOG4105ETT transcriptional Regulator, LysR family HJW98_RS14920 ENOG4107RTD sua5 ycio yrdc ywlc family protein HJW98_RS14925 ENOG4105DB7 PHP domain protein HJW98_RS14930 ENOG4105CRQ synthase (Component I) HJW98_RS14935 ENOG4108EFP Anthranilate synthase component II HJW98_RS14940 ENOG4105DK0 Indole-3-glycerol phosphate synthase HJW98_RS14945 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HJW98_RS14950 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HJW98_RS14995 ENOG4108IU3 tonb-dependent siderophore receptor HJW98_RS15000 ENOG4107E2E PKHD-type hydroxylase HJW98_RS15005 ENOG4105EIF outer membrane protein W HJW98_RS15010 ENOG4105PI0 Ferredoxin HJW98_RS15015 ENOG4108S3I UPF0259 membrane protein HJW98_RS15020 ENOG4107835 probably involved in intracellular septation (By similarity) HJW98_RS15025 ENOG4107RNH Outer membrane receptor FepA HJW98_RS15030 ENOG4105NAU thioesterase Superfamily protein HJW98_RS15035 ENOG4107PN8 YfeABCD locus regulator HJW98_RS15040 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HJW98_RS15045 ENOG4105CHR reductase HJW98_RS15050 ENOG4107K5X Membrane-bound metal-dependent hydrolase HJW98_RS15055 ENOG4108ETY sodium dicarboxylate symporter HJW98_RS15060 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HJW98_RS15065 ENOG4105CH6 catalase HJW98_RS15070 ENOG410901P UPF0249 protein HJW98_RS15075 ENOG4105F8D glycoside hydrolase family 4 HJW98_RS15080 ENOG4105EZV Transcriptional regulator HJW98_RS15085 ENOG4105VCP PTS System HJW98_RS15090 ENOG4105CK1 PTS System HJW98_RS15100 ENOG4105VZJ PTS System HJW98_RS15105 ENOG4105KKI DNA-binding transcriptional activator OsmE HJW98_RS15115 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HJW98_RS15120 ENOG4108SPG Periplasmic Protein HJW98_RS15130 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HJW98_RS15135 ENOG4105C26 Dehydrogenase HJW98_RS15140 ENOG4105F4X arginine HJW98_RS15150 ENOG4105CGK Exodeoxyribonuclease III HJW98_RS15155 ENOG4108RSN SNARE associated Golgi HJW98_RS15160 ENOG4108N5C SNARE associated Golgi protein-related protein HJW98_RS15165 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HJW98_RS15170 ENOG4105VNH ABC transporter solute-binding protein HJW98_RS15175 ENOG4105CXZ ABC transporter, permease HJW98_RS15180 ENOG4108VGW abc transporter atp-binding protein HJW98_RS15185 ENOG4107RM6 sulfurtransferase HJW98_RS15190 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HJW98_RS15195 ENOG4105M6F mutator MutT protein HJW98_RS15200 ENOG4105D82 Glutamate dehydrogenase HJW98_RS15210 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HJW98_RS15215 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HJW98_RS15220 ENOG4105SBG acid phosphatase HJW98_RS15225 ENOG41069NU Nitroreductase HJW98_RS15230 ENOG4105D07 Signal peptide peptidase, SppA HJW98_RS15235 ENOG4105HDK L-asparaginase HJW98_RS15240 ENOG4108RWI nicotinamidase HJW98_RS15250 ENOG4105N1F Hnh endonuclease HJW98_RS15255 ENOG4105VUT cytoplasmic protein HJW98_RS15260 ENOG4105E0X reductase HJW98_RS15265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJW98_RS15270 ENOG4105DSB aldose 1-epimerase HJW98_RS15275 ENOG4105CV8 reductase HJW98_RS15280 ENOG4105GNX MltA-interacting MipA family protein HJW98_RS15285 ENOG4105CYN Serine protein kinase HJW98_RS15290 ENOG4106AKX UPF0229 protein HJW98_RS15300 ENOG4108V06 Glutathione peroxidase HJW98_RS15320 ENOG4105F27 Major Facilitator HJW98_RS15325 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HJW98_RS15330 ENOG4105CBN LysR family transcriptional regulator HJW98_RS15335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HJW98_RS15340 ENOG4105KT5 UmuD protein HJW98_RS15345 ENOG4105Y50 Virulence Protein HJW98_RS15350 ENOG4108XNZ glycosyl transferase HJW98_RS15355 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HJW98_RS15360 ENOG4108VMM UPF0756 membrane protein HJW98_RS15365 ENOG4105R1U AraC Family Transcriptional Regulator HJW98_RS15370 ENOG4105DJ2 Major Facilitator Superfamily HJW98_RS15375 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HJW98_RS15380 ENOG4105EWC Purine nucleoside phosphorylase HJW98_RS15385 ENOG4105K78 MarR family Transcriptional regulator HJW98_RS15390 ENOG4105UCG Domain of unknown function (DUF333) HJW98_RS15395 ENOG4105ZTC transcriptional activator, Ogr delta HJW98_RS15535 ENOG4105ED4 portal protein HJW98_RS15560 ENOG4105DFE Dna adenine methylase HJW98_RS15600 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJW98_RS15605 ENOG410620I Diguanylate cyclase HJW98_RS15610 ENOG4106G4W HJW98_RS15625 ENOG4105S5I Membrane HJW98_RS15630 ENOG4108NIW Leucine export protein LeuE HJW98_RS15635 ENOG4105D1S lipid A biosynthesis HJW98_RS15650 ENOG4105DHT Metal Dependent Phosphohydrolase HJW98_RS15655 ENOG4106TD9 Diguanylate cyclase HJW98_RS15660 ENOG4107RSM transcriptional regulator HJW98_RS15665 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJW98_RS15695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJW98_RS15700 ENOG4105C4M (Ubiquinol oxidase) subunit I HJW98_RS15705 ENOG4105WEF catalase HJW98_RS15710 ENOG4108N8X transition metal ion binding HJW98_RS15715 ENOG4108Z9Z response to DNA damage stimulus HJW98_RS15730 ENOG4105E2A Dehydrogenase HJW98_RS15735 ENOG4105XDF Protein of unknown function (DUF1272) HJW98_RS15755 ENOG4108ZHR arsR family transcriptional regulator HJW98_RS15760 ENOG4108HMX isocitrate dehydrogenase (NADP) HJW98_RS15865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HJW98_RS15875 ENOG4105CAR Terminase, large subunit HJW98_RS15910 ENOG4105NVB glycoside hydrolase, family 19 HJW98_RS15945 ENOG4108MXB Protein of unknown function (DUF968) HJW98_RS15950 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HJW98_RS15975 ENOG4105W7J DNA binding HJW98_RS15980 ENOG410649Z repressor HJW98_RS15985 ENOG4105F2I Transposase HJW98_RS15995 ENOG4105DH7 May be involved in recombination (By similarity) HJW98_RS16030 ENOG4108I1J Integrase HJW98_RS16035 ENOG4108HMX isocitrate dehydrogenase (NADP) HJW98_RS16050 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HJW98_RS16055 ENOG41075W9 High frequency lysogenization protein HflD homolog HJW98_RS16060 ENOG4107QTF adenylosuccinate lyase HJW98_RS16080 ENOG4105IFJ Histidine kinase HJW98_RS16085 ENOG4105EZE Cupin 4 family protein HJW98_RS16105 ENOG4105D38 putrescine abc transporter HJW98_RS16110 ENOG4108HM4 ABC transporter HJW98_RS16120 ENOG4105CEY Amp-dependent synthetase and ligase HJW98_RS16125 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJW98_RS16130 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW98_RS16135 ENOG4108YZG isomerase HJW98_RS16140 ENOG4105VI0 Pts system, glucitol sorbitol-specific HJW98_RS16145 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HJW98_RS16150 ENOG4105G63 Type III effector Hrp-dependent HJW98_RS16165 ENOG4105DKT Transcriptional regulator HJW98_RS16175 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HJW98_RS16180 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HJW98_RS16185 ENOG4105D60 lipoprotein releasing system transmembrane protein HJW98_RS16190 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HJW98_RS16195 ENOG4105D60 lipoprotein releasing system transmembrane protein HJW98_RS16205 ENOG4108JA2 transcriptioN-repair coupling factor HJW98_RS16210 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW98_RS16215 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HJW98_RS16225 ENOG4108IND Tetr family transcriptional regulator HJW98_RS16240 ENOG4107MBR 17 kDa surface antigen HJW98_RS16245 ENOG4105CEP NADH dehydrogenase HJW98_RS16250 ENOG4105D0Y UPF0227 protein HJW98_RS16265 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HJW98_RS16270 ENOG41090DQ Lipoprotein HJW98_RS16275 ENOG4105K59 histidine triad (HIT) protein HJW98_RS16280 ENOG4105CI1 PTS System HJW98_RS16285 ENOG4105F8V Hydrolase, tatD family HJW98_RS16290 ENOG4107QRG dna polymerase iii HJW98_RS16295 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HJW98_RS16300 ENOG4105HHA aminodeoxychorismate lyase HJW98_RS16305 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HJW98_RS16310 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJW98_RS16315 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HJW98_RS16320 ENOG4105CHR reductase HJW98_RS16325 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HJW98_RS16330 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HJW98_RS16335 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HJW98_RS16340 ENOG4105VGS 50s ribosomal protein l32 HJW98_RS16345 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HJW98_RS16350 ENOG4108UHJ MAF-like protein HJW98_RS16355 ENOG4105EI2 Pseudouridine synthase HJW98_RS16365 ENOG4107QQB Ribonuclease E HJW98_RS16370 ENOG4105CR8 Transcriptional regulator HJW98_RS16375 ENOG4105EQ0 Major Facilitator superfamily HJW98_RS16380 ENOG4105CJR Integral membrane protein (MviN HJW98_RS16385 ENOG4105EP9 oxidoreductase HJW98_RS16390 ENOG4108YXG UPF0502 protein HJW98_RS16395 ENOG4105D9U N-acetyltransferase HJW98_RS16400 ENOG4105EV4 Multidrug resistance protein mdtH HJW98_RS16405 ENOG4105F3T (LipO)protein HJW98_RS16410 ENOG4105EKE dihydroorotase HJW98_RS16415 ENOG4105MEA DNA damage-inducible protein i HJW98_RS16420 ENOG4105PVA Biofilm formation regulatory protein BssS HJW98_RS16430 ENOG4106974 biofilm formation HJW98_RS16445 ENOG4105D1S lipid A biosynthesis HJW98_RS16455 ENOG4108W47 Acidic protein msyB HJW98_RS16460 ENOG4105NAC (LipO)protein HJW98_RS16465 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HJW98_RS16475 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HJW98_RS16490 ENOG4108UQ5 membrane protein YcdZ HJW98_RS16495 ENOG4107XHZ cytoplasmic chaperone TorD family protein HJW98_RS16505 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HJW98_RS16515 ENOG4105HEI LysR family (Transcriptional regulator HJW98_RS16520 ENOG4105EUB pirin domain protein HJW98_RS16525 ENOG4105CHJ isochorismatase hydrolase HJW98_RS16600 ENOG4108Z33 Thiol disulfide Interchange Protein HJW98_RS16605 ENOG4105D5M phosphate starvation-inducible protein HJW98_RS16610 ENOG4105DBE peroxidase HJW98_RS16615 ENOG410650H (LipO)protein HJW98_RS16625 ENOG4105D9N nucleoside HJW98_RS16640 ENOG4105CK7 Sodium proline symporter HJW98_RS16645 ENOG4105C26 Dehydrogenase HJW98_RS16655 ENOG4108R86 Transcriptional regulator HJW98_RS16660 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HJW98_RS16670 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HJW98_RS16675 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HJW98_RS16680 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HJW98_RS16685 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HJW98_RS16690 ENOG4105C2W permease HJW98_RS16700 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HJW98_RS16715 ENOG4105XH3 HJW98_RS16720 ENOG4105D6F Phosphatase HJW98_RS16730 ENOG4105CHR reductase HJW98_RS16745 ENOG4105CUB amino acid HJW98_RS16750 ENOG4105CFQ glutamine synthetase HJW98_RS16755 ENOG4108Z86 Glutamine amidotransferase HJW98_RS16760 ENOG4107VRI Transcriptional regulator HJW98_RS16765 ENOG4105C26 Dehydrogenase HJW98_RS16770 ENOG4105CJP fad dependent oxidoreductase HJW98_RS16775 ENOG4105EJC lysr family transcriptional regulator HJW98_RS16780 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HJW98_RS16785 ENOG4105C94 Transporter HJW98_RS16790 ENOG4105DVW rieske (2Fe-2S) HJW98_RS16795 ENOG4105C26 Dehydrogenase HJW98_RS16800 ENOG4105E3J oxidoreductase HJW98_RS16805 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HJW98_RS16810 ENOG4105DM4 PTS System HJW98_RS16815 ENOG4108YRF PTS System HJW98_RS16825 ENOG4108AHH pyruvate formate lyase II activase HJW98_RS16830 ENOG4108XCZ PTS System HJW98_RS16840 ENOG4106R3P AraC family transcriptional regulator HJW98_RS16845 ENOG4105BZU Histidine kinase HJW98_RS16865 ENOG4105BZU Histidine kinase HJW98_RS16885 ENOG4107QSI ABC, transporter HJW98_RS16890 ENOG4108MN8 Membrane HJW98_RS16900 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HJW98_RS16905 ENOG4108UQN AraC family transcriptional regulator HJW98_RS16910 ENOG4108V1U phospholipid-binding protein HJW98_RS16915 ENOG4105DR4 Methyltransferase HJW98_RS16920 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HJW98_RS16925 ENOG4105K4P CoA-binding domain protein HJW98_RS16935 ENOG41088T4 Helicase IV HJW98_RS16940 ENOG410901E Membrane HJW98_RS16945 ENOG4105EM2 membrane HJW98_RS16950 ENOG4108RZ1 DNA transformation protein HJW98_RS16955 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HJW98_RS16960 ENOG4105UYK outer membrane protein a HJW98_RS16965 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HJW98_RS16970 ENOG4105DAN ATP-dependent protease HJW98_RS16975 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HJW98_RS16980 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HJW98_RS16985 ENOG4108Q2G (LipO)protein HJW98_RS16990 ENOG4105DY2 Paraquat-inducible protein b HJW98_RS16995 ENOG4105F1S paraquat-inducible protein a HJW98_RS17000 ENOG4105C5H ABC transporter HJW98_RS17005 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HJW98_RS17010 ENOG4105QVC MOSC domain-containing protein HJW98_RS17015 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HJW98_RS17025 ENOG4108UZX fmn reductase HJW98_RS17030 ENOG4105GVF (ABC) transporter HJW98_RS17035 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJW98_RS17040 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HJW98_RS17050 ENOG4105CD8 aminopeptidase N HJW98_RS17055 ENOG4107RH7 Nicotinate phosphoribosyltransferase HJW98_RS17060 ENOG4105CH2 amidohydrolase HJW98_RS17065 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HJW98_RS17070 ENOG4105C44 Serine transporter HJW98_RS17075 ENOG4107RCH Diaminopropionate ammonia-lyase HJW98_RS17085 ENOG4105C5S asparaginyl-tRNA synthetase HJW98_RS17090 ENOG4105ZIT Porin Gram-negative type HJW98_RS17095 ENOG4105CGF Aromatic amino acid aminotransferase HJW98_RS17100 ENOG4105C5X domain protein HJW98_RS17105 ENOG4105EAQ (twin-arginine translocation) pathway signal HJW98_RS17110 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HJW98_RS17115 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HJW98_RS17120 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HJW98_RS17125 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HJW98_RS17130 ENOG4106371 Methyltransferase HJW98_RS17135 ENOG4107S90 membrAne HJW98_RS17140 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HJW98_RS17145 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HJW98_RS17150 ENOG4105W49 UPF0434 protein HJW98_RS17155 ENOG4105T0Z Conserved Protein HJW98_RS17160 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HJW98_RS17165 ENOG4105BZ1 (ABC) transporter HJW98_RS17170 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HJW98_RS17175 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HJW98_RS17180 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HJW98_RS17185 ENOG4105CAT Cytidine monophosphate kinase HJW98_RS17190 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HJW98_RS17195 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HJW98_RS17200 ENOG4107VMU Membrane HJW98_RS17205 ENOG4105DDY UPF0142 protein ycaO HJW98_RS17210 ENOG4105TMB Formate nitrite transporter HJW98_RS17215 ENOG4105C6N Formate acetyltransferase HJW98_RS17220 ENOG4105F1A Pyruvate formate-lyase HJW98_RS17225 ENOG4108ISG Major Facilitator HJW98_RS17235 ENOG4107KGK dmso reductase anchor subunit HJW98_RS17240 ENOG4105QAX Iron-sulfur HJW98_RS17245 ENOG4107QY8 reductase HJW98_RS17250 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HJW98_RS17255 ENOG4105D1H recombination factor protein RarA HJW98_RS17260 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HJW98_RS17265 ENOG4105CNU cell division protein FtsK HJW98_RS17270 ENOG4105EW9 transcriptional regulator AsnC family HJW98_RS17280 ENOG4105C3M thioredoxin reductase HJW98_RS17285 ENOG4108JJ9 ABC, transporter HJW98_RS17290 ENOG4108JJ8 (ABC) transporter HJW98_RS17295 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HJW98_RS17300 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HJW98_RS17305 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJW98_RS17310 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HJW98_RS17315 ENOG4105VEQ Cold shock protein HJW98_RS17325 ENOG4105DJY efflux transporter, rnd family, mfp subunit HJW98_RS17330 ENOG4105CPB ATP-dependent endonuclease of the OLD family HJW98_RS17335 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJW98_RS17340 ENOG4105DWU Membrane HJW98_RS17350 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJW98_RS17360 ENOG4105C7K acetolactate synthase HJW98_RS17365 ENOG4105C5W Aldolase HJW98_RS17370 ENOG4105CGD Nad-dependent epimerase dehydratase HJW98_RS17375 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HJW98_RS17380 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HJW98_RS17390 ENOG41064MM (LipO)protein HJW98_RS17395 ENOG4105E5Z arginine transporter ATP-binding subunit HJW98_RS17400 ENOG4106PMH Extracellular solute-binding protein family 3 HJW98_RS17405 ENOG4105GBT ABC transporter HJW98_RS17410 ENOG4105DMR ABC, transporter HJW98_RS17415 ENOG4106TNF Periplasmic binding protein HJW98_RS17420 ENOG4105BZU Histidine kinase HJW98_RS17425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJW98_RS17430 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HJW98_RS17435 ENOG4105RBQ inner membrane protein ybjO HJW98_RS17440 ENOG4105D38 putrescine abc transporter HJW98_RS17445 ENOG4105F38 ABC transporter, permease HJW98_RS17450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS17455 ENOG4107RUE extracellular solute-binding protein family 1 HJW98_RS17460 ENOG4108RMJ sensory transduction regulator HJW98_RS17470 ENOG4108DBC nitroreductase HJW98_RS17475 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HJW98_RS17480 ENOG41090BQ Glutaredoxin HJW98_RS17485 ENOG4105GWF inner membrane protein YbjM HJW98_RS17500 ENOG4108RFG Tetr family transcriptional regulator HJW98_RS17505 ENOG4106UW1 Major Facilitator superfamily HJW98_RS17510 ENOG4108HCJ Hydrolase HJW98_RS17515 ENOG4107QF7 multi-drug HJW98_RS17520 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HJW98_RS17525 ENOG4107FB0 transcriptional regulator DeoR family HJW98_RS17530 ENOG4105DZ1 carboxypeptidase HJW98_RS17540 ENOG4108TGY Glutathione S-transferase HJW98_RS17545 ENOG4105D8V Glucose sorbosone dehydrogenase HJW98_RS17550 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HJW98_RS17555 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW98_RS17560 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HJW98_RS17565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW98_RS17570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW98_RS17575 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW98_RS17580 ENOG4108JQ6 ABC transporter HJW98_RS17585 ENOG4105D44 asparaginase HJW98_RS17590 ENOG4105CVM Molybdenum cofactor synthesis domain protein HJW98_RS17595 ENOG4105D06 uba thif-type nad fad binding protein HJW98_RS17600 ENOG4105F1A Pyruvate formate-lyase HJW98_RS17610 ENOG4108HCJ Hydrolase HJW98_RS17615 ENOG41072TH Protein of unknown function (DUF1479) HJW98_RS17620 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS17625 ENOG4105DPW Major facilitator superfamily MFS_1 HJW98_RS17635 ENOG4105C5H ABC transporter HJW98_RS17640 ENOG4105M2Z protein tyrosine serine phosphatase HJW98_RS17645 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW98_RS17650 ENOG4108TZY GntR Family Transcriptional Regulator HJW98_RS17655 ENOG4105CS2 ec 3.2.1.21 HJW98_RS17660 ENOG4105F4P )-transporter HJW98_RS17665 ENOG4105KST dependent repressor HJW98_RS17675 ENOG4108I6E Sulfatase HJW98_RS17680 ENOG4108T1M outer membrane protein x HJW98_RS17695 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HJW98_RS17700 ENOG4107R0W ABC transporter HJW98_RS17705 ENOG4105E5Q amino acid AbC transporter HJW98_RS17710 ENOG4105CDA abc transporter atp-binding protein HJW98_RS17715 ENOG4105D8X mechanosensitive ion channel HJW98_RS17720 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HJW98_RS17725 ENOG4105EW6 flavin reductase domain protein, FMN-binding HJW98_RS17735 ENOG4105KSC Transcriptional regulator, TraR DksA family HJW98_RS17740 ENOG4105VR4 UPF0379 protein ybiJ HJW98_RS17745 ENOG4108MTB glycosyl transferase family HJW98_RS17750 ENOG4105DVT helicase HJW98_RS17755 ENOG4105C1J atp-dependent rna helicase HJW98_RS17775 ENOG4105DJB Major Facilitator Superfamily HJW98_RS17785 ENOG4108PZW LysR family Transcriptional regulator HJW98_RS17790 ENOG4107MVR Transcriptional regulator HJW98_RS17795 ENOG4105D0S secretion protein (HlyD HJW98_RS17800 ENOG4105CJ1 ABC, transporter HJW98_RS17805 ENOG4107QWP ABC-2 type transporter HJW98_RS17810 ENOG4107QWP ABC-2 type transporter HJW98_RS17815 ENOG4105I9U inner membrane protein ybhQ HJW98_RS17820 ENOG4105X23 Endonuclease Exonuclease phosphatase HJW98_RS17825 ENOG4105DZQ phospholipase D Transphosphatidylase HJW98_RS17830 ENOG4107UXM Membrane HJW98_RS17835 ENOG4105HFZ Membrane HJW98_RS17840 ENOG4108ZAF Molybdopterin HJW98_RS17845 ENOG4105M00 molybdopterin converting factor, subunit 1 HJW98_RS17850 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HJW98_RS17855 ENOG4108RIR Molybdenum cofactor biosynthesis protein HJW98_RS17860 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HJW98_RS17865 ENOG4105CHW UPF0052 protein HJW98_RS17870 ENOG4105DIJ Phosphoethanolamine transferase HJW98_RS17875 ENOG4105XJC Two component transcriptional regulator (Winged helix family HJW98_RS17880 ENOG4105ECM Sensor protein basS pmrB HJW98_RS17885 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HJW98_RS17895 ENOG4108IV0 ABC, transporter HJW98_RS17905 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HJW98_RS17910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HJW98_RS17915 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HJW98_RS17920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HJW98_RS17925 ENOG4108V1U phospholipid-binding protein HJW98_RS17930 ENOG4105C85 amino acid HJW98_RS17935 ENOG4105C84 Histidine ammonia-lyase HJW98_RS17940 ENOG4105CGP Urocanate hydratase HJW98_RS17955 ENOG41088SP formiminoglutamate hydrolase HJW98_RS17960 ENOG4105CI2 imidazolone-5-propionate hydrolase HJW98_RS17965 ENOG4105NBR Pectinesterase HJW98_RS17975 ENOG4108U51 Universal stress protein HJW98_RS17980 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJW98_RS18015 ENOG4108XDN Transcriptional regulator HJW98_RS18020 ENOG4105BZU Histidine kinase HJW98_RS18025 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HJW98_RS18040 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HJW98_RS18045 ENOG4108K4B hydrolase HJW98_RS18055 ENOG4105E0C molybdate abc transporter HJW98_RS18060 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HJW98_RS18070 ENOG4105F4R Transcriptional regulator mode HJW98_RS18080 ENOG4105DKW ABC transporter HJW98_RS18085 ENOG4105CMR udp-glucose 4-epimerase HJW98_RS18090 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HJW98_RS18095 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HJW98_RS18100 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HJW98_RS18105 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HJW98_RS18110 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJW98_RS18115 ENOG4105JND homeobox protein HJW98_RS18120 ENOG4105PGM cation diffusion facilitator family transporter HJW98_RS18125 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HJW98_RS18130 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HJW98_RS18175 ENOG4105UFD tol-pal system protein YbgF HJW98_RS18180 ENOG4105KCK Peptidoglycan-associated lipoprotein HJW98_RS18190 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HJW98_RS18190 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HJW98_RS18200 ENOG4105E02 MotA TolQ exbB proton channel HJW98_RS18205 ENOG4107YD3 Thioesterase HJW98_RS18210 ENOG4105KJB cyd operon protein YbgE HJW98_RS18220 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJW98_RS18225 ENOG4105C4M (Ubiquinol oxidase) subunit I HJW98_RS18235 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HJW98_RS18240 ENOG4105CMV Succinyl-CoA synthetase subunit beta HJW98_RS18245 ENOG4105C7S Dehydrogenase HJW98_RS18250 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HJW98_RS18255 ENOG4105E33 succinate dehydrogenase HJW98_RS18260 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HJW98_RS18265 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HJW98_RS18270 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HJW98_RS18275 ENOG4105BZN citrate synthase HJW98_RS18280 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HJW98_RS18300 ENOG4105E7W lamb ycsf family protein HJW98_RS18305 ENOG4107R7A Allophanate hydrolase subunit 2 HJW98_RS18310 ENOG4105P4J Allophanate hydrolase, subunit 1 HJW98_RS18315 ENOG4107QNR UPF0135 protein HJW98_RS18320 ENOG4105DUX Transporter HJW98_RS18325 ENOG4105CVP deoxyribo-dipyrimidine photolyase HJW98_RS18330 ENOG4105XIQ Protein of unknown function (DUF2517) HJW98_RS18345 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HJW98_RS18350 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HJW98_RS18355 ENOG4105C08 Histidine kinase HJW98_RS18360 ENOG4105EEX Two component transcriptional regulator (Winged helix family HJW98_RS18370 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HJW98_RS18375 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HJW98_RS18380 ENOG4105EV9 Alpha Beta Hydrolase HJW98_RS18385 ENOG4105NNH LexA regulated protein HJW98_RS18390 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HJW98_RS18395 ENOG41090R7 Ferric uptake HJW98_RS18400 ENOG4105CSH Transporter HJW98_RS18405 ENOG4105GX6 (LipO)protein HJW98_RS18410 ENOG4105J5J Outer membrane porin HJW98_RS18420 ENOG4105CX6 glutaminyL-tRNA synthetase HJW98_RS18425 ENOG4105CI1 PTS System HJW98_RS18430 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HJW98_RS18435 ENOG4105CE4 GlcNAc 6-P deacetylase HJW98_RS18440 ENOG4105E2R ROK family HJW98_RS18445 ENOG4105D4U had-superfamily hydrolase, subfamily iia HJW98_RS18450 ENOG4105CAQ asparagine synthetase HJW98_RS18490 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HJW98_RS18495 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HJW98_RS18500 ENOG4105C9A Phoh family HJW98_RS18505 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HJW98_RS18510 ENOG4108JU5 Magnesium and cobalt efflux protein HJW98_RS18515 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HJW98_RS18520 ENOG4107RP9 extracellular solute-binding protein, family 3 HJW98_RS18525 ENOG4105EAD ABC transporter HJW98_RS18530 ENOG4105DRP amino acid AbC transporter HJW98_RS18535 ENOG4105CDA abc transporter atp-binding protein HJW98_RS18550 ENOG4107PAI alpha helical protein HJW98_RS18555 ENOG4105C8T Leucyl-tRNA synthetase HJW98_RS18565 ENOG4105DJF DNA polymerase III, delta' subunit HJW98_RS18570 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HJW98_RS18575 ENOG4108TGR phosphatase HJW98_RS18580 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HJW98_RS18585 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HJW98_RS18590 ENOG4105CJN penicillin-binding protein HJW98_RS18595 ENOG4105CNI cell division protein FtsW HJW98_RS18600 ENOG4105K6T rare lipoprotein A HJW98_RS18605 ENOG4105DZ1 carboxypeptidase HJW98_RS18610 ENOG4108Z43 UPF0250 protein HJW98_RS18615 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HJW98_RS18620 ENOG41064T2 transcriptional regulator, lysR family HJW98_RS18625 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HJW98_RS18630 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HJW98_RS18650 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HJW98_RS18655 ENOG4105CEE C4-dicarboxylate transporter HJW98_RS18660 ENOG4105KTS ribonuclease HJW98_RS18665 ENOG4105NXH GreA GreB family elongation factor HJW98_RS18670 ENOG4108U51 Universal stress protein HJW98_RS18675 ENOG4108JU3 Alkyl hydroperoxide reductase HJW98_RS18680 ENOG4105D3R alkyl hydroperoxide reductase HJW98_RS18685 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HJW98_RS18690 ENOG4105DQS Transcriptional regulator HJW98_RS18695 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HJW98_RS18700 ENOG4105GTN ParB Domain Protein Nuclease HJW98_RS18705 ENOG4105CHM Aminotransferase HJW98_RS18710 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HJW98_RS18715 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HJW98_RS18730 ENOG4105C2J ABC transporter HJW98_RS18740 ENOG4105CNN ABC, transporter HJW98_RS18750 ENOG4108M3J Dehydrogenase HJW98_RS18760 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HJW98_RS18765 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HJW98_RS18775 ENOG4105DZC cytosine deaminase HJW98_RS18785 ENOG4105ECY inositol monophosphatase HJW98_RS18790 ENOG4105CXY transporter HJW98_RS18795 ENOG4105D6F Phosphatase HJW98_RS18800 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HJW98_RS18805 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HJW98_RS18820 ENOG4105CNN ABC, transporter HJW98_RS18825 ENOG4105C2J ABC transporter HJW98_RS18830 ENOG4107SCQ Iron-containing alcohol dehydrogenase HJW98_RS18835 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HJW98_RS18850 ENOG4105VCD cytoplasmic protein HJW98_RS18855 ENOG4105D22 carbon starvation protein HJW98_RS18860 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HJW98_RS18865 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HJW98_RS18870 ENOG4105WQI isochorismatase HJW98_RS18875 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HJW98_RS18880 ENOG4105E4F Isochorismate synthase HJW98_RS18885 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HJW98_RS18890 ENOG4105E8G Major facilitator Superfamily HJW98_RS18895 ENOG4105DQ5 transport system permease protein HJW98_RS18900 ENOG4105TVJ transport system, permease HJW98_RS18905 ENOG4105E0A ABC, transporter HJW98_RS18910 ENOG4105C0W non-ribosomal peptide synthetase HJW98_RS18915 ENOG41085A6 mbth domain-containing protein HJW98_RS18920 ENOG4105E93 esterase HJW98_RS18925 ENOG4107RNH Outer membrane receptor FepA HJW98_RS18930 ENOG4108TSE Transferase HJW98_RS18935 ENOG4108IUS Transketolase HJW98_RS18940 ENOG4108HHA Transketolase HJW98_RS18945 ENOG4105DKT Transcriptional regulator HJW98_RS18950 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HJW98_RS18955 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJW98_RS18965 ENOG4105C2J ABC transporter HJW98_RS18970 ENOG4105CNN ABC, transporter HJW98_RS18995 ENOG410810E transcriptional regulator, lysR family HJW98_RS19000 ENOG4105CUY Mechanosensitive ion channel HJW98_RS19005 ENOG4108WN0 inhibitor of vertebrate lysozyme HJW98_RS19010 ENOG4105C94 Transporter HJW98_RS19025 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HJW98_RS19035 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW98_RS19040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW98_RS19045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW98_RS19050 ENOG4105C3U ABC transporter HJW98_RS19055 ENOG4108JQ7 (ABC) transporter HJW98_RS19065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HJW98_RS19070 ENOG4105EMU Dehydrogenase HJW98_RS19080 ENOG4105GBT ABC transporter HJW98_RS19085 ENOG4105DRP amino acid AbC transporter HJW98_RS19090 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HJW98_RS19100 ENOG4105CHM Aminotransferase HJW98_RS19105 ENOG4105T38 integral membrane protein HJW98_RS19110 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HJW98_RS19115 ENOG4108T58 Mg2 transport protein CorA HJW98_RS19145 ENOG4105WQ6 Membrane HJW98_RS19150 ENOG4105HFT AraC family transcriptional regulator HJW98_RS19160 ENOG410630P Transcriptional regulator HJW98_RS19165 ENOG4105MSB protein, conserved in bacteria HJW98_RS19170 ENOG4108RCM Nitroreductase HJW98_RS19200 ENOG4105CUY Mechanosensitive ion channel HJW98_RS19205 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS19215 ENOG4105CK5 oxidoreductase HJW98_RS19225 ENOG4105EAA nucleoside HJW98_RS19230 ENOG4105C85 amino acid HJW98_RS19240 ENOG4108NS2 receptor HJW98_RS19245 ENOG4105C26 Dehydrogenase HJW98_RS19250 ENOG4105CJP fad dependent oxidoreductase HJW98_RS19260 ENOG4105CUB amino acid HJW98_RS19275 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HJW98_RS19280 ENOG4105DGU Histone deacetylase HJW98_RS19290 ENOG4108UAJ Transcriptional regulator HJW98_RS19300 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HJW98_RS19315 ENOG4105CPC Aldo Keto reductase HJW98_RS19320 ENOG4105E89 ABC transporter HJW98_RS19325 ENOG4105CH2 amidohydrolase HJW98_RS19360 ENOG4105EHG Permease protein HJW98_RS19365 ENOG4105E0A ABC, transporter HJW98_RS19370 ENOG4105EFX secretion protein, HlyD family HJW98_RS19375 ENOG4105KK7 inner membrane protein YiaW HJW98_RS19390 ENOG4105D7K pfkb domain protein HJW98_RS19395 ENOG4108M0B Sucrose porin HJW98_RS19400 ENOG4105C5Y PTS System HJW98_RS19405 ENOG4108HKT sucrose-6-phosphate hydrolase HJW98_RS19410 ENOG4105WBN Transcriptional regulator (LacI family HJW98_RS19425 ENOG4108HWV )-transporter HJW98_RS19430 ENOG4105C2J ABC transporter HJW98_RS19470 ENOG4105CRK lysyL-tRNA synthetase HJW98_RS19475 ENOG4105DUX Transporter HJW98_RS19480 ENOG4105CXN decarboxylase HJW98_RS19485 ENOG4105D5Q Arginine ornithine antiporter HJW98_RS19490 ENOG4108M3R transcriptional activator CadC HJW98_RS19500 ENOG4105D1S lipid A biosynthesis HJW98_RS19515 ENOG4105CW0 outer membrane usher protein HJW98_RS19520 ENOG4105GQR Chaperone HJW98_RS19525 ENOG4105X0I Fimbrial HJW98_RS19540 ENOG4105BZN citrate synthase HJW98_RS19575 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HJW98_RS19580 ENOG4105WQ3 Rna-binding protein HJW98_RS19585 ENOG4105C8N cysteinyl-tRNA synthetase HJW98_RS19590 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HJW98_RS19595 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HJW98_RS19605 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HJW98_RS19610 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HJW98_RS19630 ENOG4105CV6 ABC transporter, permease HJW98_RS19635 ENOG4108I0Y (ABC) transporter HJW98_RS19640 ENOG4108UJV acyl-CoA thioesterase i HJW98_RS19645 ENOG4105E1F short-chain dehydrogenase reductase HJW98_RS19650 ENOG4107QR8 Thioredoxin HJW98_RS19655 ENOG4105C4B ABC transporter, permease HJW98_RS19660 ENOG41083J0 (ABC) transporter HJW98_RS19665 ENOG4107QX8 SPFH domain, Band 7 family protein HJW98_RS19670 ENOG4105G5H Membrane HJW98_RS19675 ENOG4108Z6Z Transcriptional regulator HJW98_RS19680 ENOG4105C59 p-type ATPase HJW98_RS19685 ENOG4105MBR gumn family HJW98_RS19690 ENOG4108Z66 YbaK ebsC protein HJW98_RS19695 ENOG4105CGH 5'-nucleotidase HJW98_RS19700 ENOG4105EU0 Major facilitator Superfamily HJW98_RS19715 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJW98_RS19720 ENOG4107RE1 Inosine-guanosine kinase HJW98_RS19730 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HJW98_RS19735 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HJW98_RS19740 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HJW98_RS19745 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HJW98_RS19750 ENOG4107QMP dna polymerase iii subunits gamma and tau HJW98_RS19755 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HJW98_RS19760 ENOG4105WD1 Membrane HJW98_RS19765 ENOG4108URS primosomal replication protein n'' HJW98_RS19770 ENOG4106428 Protein of unknown function (DUF2496) HJW98_RS19780 ENOG4105EGS Mechanosensitive ion channel HJW98_RS19785 ENOG4107XI7 Tetr family transcriptional regulator HJW98_RS19790 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW98_RS19795 ENOG4105BZS acriflavin resistance protein HJW98_RS19800 ENOG4108UKR Biofilm formation regulator YbaJ HJW98_RS19810 ENOG4108UW5 maltose o-acetyltransferase HJW98_RS19820 ENOG4105GSJ Inner membrane protein ylaC HJW98_RS19835 ENOG4105YK5 50S ribosomal protein L36 HJW98_RS19845 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS19850 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW98_RS19855 ENOG4105CI1 PTS System HJW98_RS19860 ENOG4105C4C beta-galactosidase HJW98_RS19870 ENOG4105EG2 ABC transporter, permease HJW98_RS19880 ENOG4107FKK extracellular solute-binding protein family 1 HJW98_RS19895 ENOG41066DG (EAL) domain protein HJW98_RS19900 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HJW98_RS19905 ENOG41061MD high-affinity nickel-transporter HJW98_RS19910 ENOG4108VW9 Membrane HJW98_RS19940 ENOG41080UX Methyltransferase HJW98_RS19945 ENOG4108MNP Glycoprotein polysaccharide metabolism HJW98_RS19950 ENOG4105C29 acyl-CoA thioesterase HJW98_RS19955 ENOG4105BZU Histidine kinase HJW98_RS19960 ENOG4108YZA Nitrogen regulatory protein pii HJW98_RS19965 ENOG4105BZ1 (ABC) transporter HJW98_RS19970 ENOG4105BZ1 (ABC) transporter HJW98_RS19975 ENOG4108XM1 transcriptional regulator AsnC family HJW98_RS19985 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HJW98_RS19990 ENOG4108NFA extracellular solute-binding protein HJW98_RS19995 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HJW98_RS20000 ENOG4108TGP Thioesterase superfamily protein HJW98_RS20005 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HJW98_RS20010 ENOG4105EIN peptidylprolyl cis-trans isomerase HJW98_RS20015 ENOG4105K70 DNA-binding protein HJW98_RS20020 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HJW98_RS20025 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HJW98_RS20035 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HJW98_RS20045 ENOG4105M85 Bola protein HJW98_RS20050 ENOG4105IEY (LipO)protein HJW98_RS20055 ENOG4105EYM Major Facilitator superfamily HJW98_RS20060 ENOG4105E2S oxidase) subunit II HJW98_RS20065 ENOG4105BZ9 Cytochrome C oxidase, subunit I HJW98_RS20070 ENOG4105CCU oxidase (Subunit III) HJW98_RS20075 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HJW98_RS20080 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HJW98_RS20090 ENOG4107HP6 Transcriptional regulator HJW98_RS20095 ENOG4105E2X shikimate dehydrogenase HJW98_RS20100 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HJW98_RS20110 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HJW98_RS20120 ENOG4105D2S major facilitator superfamily HJW98_RS20125 ENOG4105CIB oxidoreductase Domain protein HJW98_RS20130 ENOG4107RDB Major Facilitator HJW98_RS20140 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HJW98_RS20145 ENOG4107S0N DJ-1 family HJW98_RS20155 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HJW98_RS20160 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HJW98_RS20165 ENOG4105CTB Polyprenyl synthetase HJW98_RS20170 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HJW98_RS20175 ENOG4105CPC Aldo Keto reductase HJW98_RS20180 ENOG4108ZAI phosphatidylglycerophosphatase a HJW98_RS20185 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HJW98_RS20190 ENOG4107YIM Involved in the transcription termination process (By similarity) HJW98_RS20195 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HJW98_RS20200 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HJW98_RS20205 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HJW98_RS20210 ENOG4108KIC (LipO)protein HJW98_RS20215 ENOG4105DRB nucleoside-specific channel-forming protein HJW98_RS20230 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HJW98_RS20235 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HJW98_RS20240 ENOG4105VIE preprotein translocase, subunit YajC HJW98_RS20245 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HJW98_RS20250 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HJW98_RS20260 ENOG4108ZYK Acyl carrier protein phosphodiesterase HJW98_RS20265 ENOG4105D3R alkyl hydroperoxide reductase HJW98_RS20275 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HJW98_RS20290 ENOG4108MGF sugar kinase HJW98_RS20300 ENOG4105CI2 imidazolone-5-propionate hydrolase HJW98_RS20310 ENOG4105CHJ isochorismatase hydrolase HJW98_RS20315 ENOG4105EQ1 Transcriptional regulator HJW98_RS20320 ENOG4107R28 alpha amylase, catalytic region HJW98_RS20325 ENOG4105C85 amino acid HJW98_RS20330 ENOG4105CWM branched-chain amino acid transport system II carrier protein HJW98_RS20335 ENOG4105BZU Histidine kinase HJW98_RS20340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJW98_RS20345 ENOG4107RH8 nuclease SbcCD subunit D HJW98_RS20350 ENOG4105EYH Exonuclease HJW98_RS20355 ENOG4105DKQ ROK family HJW98_RS20360 ENOG4105DH7 May be involved in recombination (By similarity) HJW98_RS20365 ENOG4105NBK UPF0345 protein HJW98_RS20370 ENOG4105HBA AroM protein HJW98_RS20375 ENOG4105SS3 HJW98_RS20380 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HJW98_RS20385 ENOG4105G4C Periplasmic ligand-binding sensor protein HJW98_RS20390 ENOG4108UPT UPF0178 protein HJW98_RS20395 ENOG4105II7 pyrroline-5-carboxylate reductase HJW98_RS20400 ENOG4105VIF phosphate starvation-inducible protein HJW98_RS20405 ENOG4105G6Z alkaline phosphatase HJW98_RS20425 ENOG4105CPF Cell wall formation (By similarity) HJW98_RS20430 ENOG4105UNH Membrane HJW98_RS20435 ENOG4105FR5 inner membrane protein YaiY HJW98_RS20440 ENOG4107QS8 (LipO)protein HJW98_RS20445 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HJW98_RS20450 ENOG4108RWI nicotinamidase HJW98_RS20455 ENOG4107R6D beta-lactam binding protein AmpH HJW98_RS20460 ENOG4105D52 delta-aminolevulinic acid dehydratase HJW98_RS20465 ENOG4108UK5 Transposase HJW98_RS20475 ENOG4105E2B Taurine dioxygenase HJW98_RS20480 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HJW98_RS20485 ENOG4108ETV ABC transporter HJW98_RS20490 ENOG4106FTQ Taurine ABC transporter, periplasmic HJW98_RS20495 ENOG4107QK5 Homocysteine s-methyltransferase HJW98_RS20500 ENOG4108IQI permease HJW98_RS20510 ENOG4105C85 amino acid HJW98_RS20515 ENOG4105CPD ethanolamine ammonia-lyase HJW98_RS20520 ENOG4107FQ9 ethanolamine ammonia-lyase HJW98_RS20535 ENOG4105C32 Amino acid ABC transporter (Permease) HJW98_RS20540 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJW98_RS20545 ENOG4105C0Z ABC transporter HJW98_RS20550 ENOG4108IV0 ABC, transporter HJW98_RS20560 ENOG4105CT1 (ABC) transporter HJW98_RS20565 ENOG4105CDA abc transporter atp-binding protein HJW98_RS20570 ENOG4105E5Q amino acid AbC transporter HJW98_RS20575 ENOG4105DRP amino acid AbC transporter HJW98_RS20585 ENOG4106PYX Receptor HJW98_RS20590 ENOG4108N3D putative enzyme HJW98_RS20595 ENOG4108NN8 Fimbrial protein HJW98_RS20600 ENOG4108GWT fimbrillin MatB HJW98_RS20605 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HJW98_RS20615 ENOG4105EHI Phosphonate ABC transporter, periplasmic HJW98_RS20625 ENOG4105S7S phosphonate abc transporter HJW98_RS20645 ENOG4108QBX (LipO)protein HJW98_RS20650 ENOG4105FCK Membrane HJW98_RS20655 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HJW98_RS20680 ENOG4105CW0 outer membrane usher protein HJW98_RS20685 ENOG4108AF8 Chaperone HJW98_RS20690 ENOG4106EAR Fimbrial protein HJW98_RS20710 ENOG4108TC1 Transcriptional regulator HJW98_RS20725 ENOG4108T1M outer membrane protein x HJW98_RS20740 ENOG4105CXC rtn protein HJW98_RS20760 ENOG4108VEV chaperone HJW98_RS20785 ENOG4105DTA methyltransferase HJW98_RS20790 ENOG4105YCT UPF0386 protein HJW98_RS20800 ENOG4105D5U fad dependent oxidoreductase HJW98_RS20805 ENOG4105C26 Dehydrogenase HJW98_RS20810 ENOG4108JPW Aminotransferase HJW98_RS20815 ENOG4105C85 amino acid HJW98_RS20820 ENOG4108PVQ transcriptional regulator HJW98_RS20825 ENOG4105D3Q Sugar transferase HJW98_RS20855 ENOG4106WTF Glycosyl transferase, family 2 HJW98_RS20860 ENOG4105CG5 Glycosyl transferase (Group 1 HJW98_RS20865 ENOG4107RA4 Glycosyl transferase (Group 1 HJW98_RS20880 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HJW98_RS20885 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HJW98_RS20890 ENOG4105V1F Fermentation respiration switch protein HJW98_RS20895 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HJW98_RS20900 ENOG4105CIN aminoacyl-histidine dipeptidase HJW98_RS20905 ENOG4108HYG acetyltransferase HJW98_RS20910 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HJW98_RS20925 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HJW98_RS20930 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW98_RS20935 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW98_RS20940 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW98_RS20945 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW98_RS20950 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW98_RS20955 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HJW98_RS20960 ENOG4105E7A Glutamine amidotransferase HJW98_RS20965 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HJW98_RS20970 ENOG4107QPN acyl-Coa dehydrogenase HJW98_RS20975 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HJW98_RS20980 ENOG4108VP3 Lysine exporter protein (LysE YggA) HJW98_RS20985 ENOG41090KR LysR family transcriptional Regulator HJW98_RS20995 ENOG4107RZZ dna polymerase iii epsilon subunit HJW98_RS21000 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HJW98_RS21005 ENOG4105D1A Methyltransferase HJW98_RS21010 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HJW98_RS21015 ENOG4105E9H Lytic Murein transglycosylase HJW98_RS21020 ENOG4105F2W methyltransferase HJW98_RS21030 ENOG4105F27 Major Facilitator HJW98_RS21035 ENOG4105HEI LysR family (Transcriptional regulator HJW98_RS21040 ENOG4105CV8 reductase HJW98_RS21075 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HJW98_RS21080 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS21085 ENOG4108UMI ABC transporter, permease HJW98_RS21090 ENOG4105D01 (LipO)protein HJW98_RS21095 ENOG4108R8X outer membrane lipoprotein HJW98_RS21100 ENOG4108R96 Methyltransferase, YaeB family HJW98_RS21105 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HJW98_RS21110 ENOG4108UY0 (LipO)protein HJW98_RS21115 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HJW98_RS21120 ENOG4108YZN class I peptide chain release factor HJW98_RS21125 ENOG4108VWS Yaeq family HJW98_RS21130 ENOG4105W1I UPF0253 protein HJW98_RS21135 ENOG4105M1T rho-binding antiterminator HJW98_RS21140 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HJW98_RS21145 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HJW98_RS21150 ENOG4105CXN decarboxylase HJW98_RS21155 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HJW98_RS21160 ENOG4105C0B DNA polymerase III (alpha subunit) HJW98_RS21165 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HJW98_RS21170 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW98_RS21175 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW98_RS21180 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HJW98_RS21185 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW98_RS21190 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HJW98_RS21195 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJW98_RS21200 ENOG4105DZP Membrane-associated zinc metalloprotease HJW98_RS21205 ENOG4105KNE Phosphatidate cytidylyltransferase HJW98_RS21215 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HJW98_RS21225 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HJW98_RS21230 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HJW98_RS21235 ENOG4105CE9 30S ribosomal protein S2 HJW98_RS21240 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HJW98_RS21245 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HJW98_RS21250 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HJW98_RS21255 ENOG4108T8E UPF0325 protein HJW98_RS21260 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HJW98_RS21265 ENOG4105C0H protease HJW98_RS21270 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HJW98_RS21275 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HJW98_RS21280 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HJW98_RS21285 ENOG4105EN6 Membrane HJW98_RS21290 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HJW98_RS21295 ENOG4105CMQ Chloride channel HJW98_RS21300 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HJW98_RS21305 ENOG4105S6R Iron-hydroxamate transporter permease subunit HJW98_RS21310 ENOG4105J76 Periplasmic binding protein HJW98_RS21315 ENOG4105E0A ABC, transporter HJW98_RS21320 ENOG4105E0K tonB-dependent siderophore receptor HJW98_RS21325 ENOG4105BZ4 penicillin-binding protein HJW98_RS21420 ENOG4105CQ7 ATP-dependent helicase HJW98_RS21425 ENOG4107XID 2'-5' rna ligase HJW98_RS21430 ENOG4105PW4 Sugar fermentation stimulation protein homolog HJW98_RS21435 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HJW98_RS21440 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HJW98_RS21445 ENOG4105DJ0 Poly(A) Polymerase HJW98_RS21450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HJW98_RS21455 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HJW98_RS21460 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HJW98_RS21465 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HJW98_RS21470 ENOG4107BJW polysaccharide deacetylase HJW98_RS21475 ENOG4108YTN IIa component HJW98_RS21480 ENOG4105E3A (ABC) transporter HJW98_RS21485 ENOG4105DA5 (ABC) transporter HJW98_RS21490 ENOG41077A9 carbonic anhydrase HJW98_RS21495 ENOG4108UGV hypoxanthine phosphoribosyltransferase HJW98_RS21505 ENOG4105DZG Dehydrogenase HJW98_RS21510 ENOG4105E3B Multicopper oxidase HJW98_RS21515 ENOG4108ZRK uncharacterized protein yacC HJW98_RS21535 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HJW98_RS21540 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HJW98_RS21545 ENOG4108ZIG UPF0231 protein HJW98_RS21550 ENOG4107QIJ Aconitate hydratase 2 HJW98_RS21560 ENOG4108NST exported protein HJW98_RS21575 ENOG4107QN2 dihydrolipoyl dehydrogenase HJW98_RS21580 ENOG4107QSN dihydrolipoamide acetyltransferase HJW98_RS21585 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HJW98_RS21590 ENOG41073TP transcriptional regulator HJW98_RS21595 ENOG4105C85 amino acid HJW98_RS21600 ENOG4105CT4 transporter HJW98_RS21605 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HJW98_RS21610 ENOG4106A72 regulatory protein AmpE HJW98_RS21615 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HJW98_RS21620 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HJW98_RS21625 ENOG4108ZUW Major pilin subunit HJW98_RS21630 ENOG4107QHF type ii secretion system protein e HJW98_RS21635 ENOG4105D7Q type ii secretion system HJW98_RS21640 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HJW98_RS21645 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HJW98_RS21650 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HJW98_RS21655 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HJW98_RS21660 ENOG4105M6F mutator MutT protein HJW98_RS21665 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HJW98_RS21670 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HJW98_RS21675 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW98_RS21680 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HJW98_RS21685 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HJW98_RS21690 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HJW98_RS21700 ENOG4105DFU Cell wall formation (By similarity) HJW98_RS21705 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HJW98_RS21710 ENOG4105CNI cell division protein FtsW HJW98_RS21720 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HJW98_RS21725 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HJW98_RS21730 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HJW98_RS21735 ENOG4105CJN penicillin-binding protein HJW98_RS21740 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HJW98_RS21745 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HJW98_RS21755 ENOG4107B7Y DNA-binding transcriptional regulator FruR HJW98_RS21760 ENOG4108ZP8 Acetolactate synthase small subunit HJW98_RS21765 ENOG4105C7K acetolactate synthase HJW98_RS21770 ENOG41064T2 transcriptional regulator, lysR family HJW98_RS21785 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HJW98_RS21795 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HJW98_RS21800 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HJW98_RS21815 ENOG4105EMV Major Facilitator HJW98_RS21820 ENOG4105FF2 Type I DHQase HJW98_RS21825 ENOG4105C5Q Transcriptional regulator HJW98_RS21830 ENOG4105DJB Major Facilitator Superfamily HJW98_RS21835 ENOG4105S8Q sugar efflux transporter HJW98_RS21860 ENOG4106SMU thiamine transporter membrane protein HJW98_RS21870 ENOG4108KF1 Membrane HJW98_RS21875 ENOG41063TF transcriptional regulator (AraC HJW98_RS21885 ENOG4105EF1 ribulokinase HJW98_RS21890 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HJW98_RS21895 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HJW98_RS21900 ENOG4105CQ2 DNA polymerase HJW98_RS21905 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HJW98_RS21910 ENOG4105D3G Pseudouridine synthase HJW98_RS21920 ENOG4105D2K citrate carrier protein HJW98_RS21925 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HJW98_RS21930 ENOG4106YYS transcriptional regulatory protein HJW98_RS21935 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HJW98_RS21940 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HJW98_RS21950 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HJW98_RS21955 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HJW98_RS21965 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HJW98_RS21970 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HJW98_RS21975 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJW98_RS21985 ENOG4105M5B (LipO)protein HJW98_RS21990 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HJW98_RS21995 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HJW98_RS22005 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HJW98_RS22010 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HJW98_RS22015 ENOG4105EXG Transcriptional regulator HJW98_RS22020 ENOG4105KAF membrAne HJW98_RS22025 ENOG4105DU0 nucleoside hydrolase HJW98_RS22030 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HJW98_RS22035 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HJW98_RS22040 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HJW98_RS22050 ENOG4105DTN riboflavin biosynthesis protein ribF HJW98_RS22070 ENOG41063Z6 transcriptional regulator, lysR family HJW98_RS22075 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HJW98_RS22080 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HJW98_RS22085 ENOG4105CFG Acts as a chaperone (By similarity) HJW98_RS22090 ENOG4108WTA UPF0412 protein YaaI HJW98_RS22095 ENOG4108QUJ UPF0174 protein YaaW HJW98_RS22100 ENOG4106HK8 GPR1 FUN34 yaaH family protein HJW98_RS22105 ENOG4105CSH Transporter HJW98_RS22110 ENOG4108RIR Molybdenum cofactor biosynthesis protein HJW98_RS22115 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW98_RS22120 ENOG4105BZG amino acid carrier protein HJW98_RS22125 ENOG4105D1Q UPF0246 protein HJW98_RS22135 ENOG4105D98 threonine synthase HJW98_RS22140 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HJW98_RS22145 ENOG4105CFH Aspartokinase HJW98_RS22160 ENOG4106FVC RNA methyltransferase HJW98_RS22165 ENOG410759A HJW98_RS22170 ENOG41065U4 response regulator HJW98_RS22175 ENOG4105CT7 inner membrane cred family protein HJW98_RS22180 ENOG4105EB3 Histidine kinase HJW98_RS22185 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJW98_RS22190 ENOG4108RH0 Crea protein HJW98_RS22195 ENOG4105UEI Transcriptional Regulator AraC Family HJW98_RS22200 ENOG4105CVJ phosphoglycerate mutase HJW98_RS22205 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HJW98_RS22210 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HJW98_RS22215 ENOG4107SC1 transglycosylase HJW98_RS22220 ENOG4105C5H ABC transporter HJW98_RS22225 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HJW98_RS22230 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HJW98_RS22235 ENOG4105EAC phosphoserine phosphatase HJW98_RS22240 ENOG41062Z9 Membrane HJW98_RS22245 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HJW98_RS22260 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HJW98_RS22270 ENOG4105D9N nucleoside HJW98_RS22275 ENOG4105EYA deoxyribonuclease HJW98_RS22280 ENOG4108NRW Phospholipase, patatin family HJW98_RS22285 ENOG41075IC Protein of unknown function (DUF1328) HJW98_RS22290 ENOG4105K3G Periplasmic Protein HJW98_RS22295 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HJW98_RS22300 ENOG4105PAD Hydrolase HJW98_RS22305 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HJW98_RS22310 ENOG4108WPU DNA polymerase III subunit psi HJW98_RS22315 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HJW98_RS22335 ENOG4105YBH Protein of unknown function (DUF1435) HJW98_RS22345 ENOG4106TD9 Diguanylate cyclase HJW98_RS22350 ENOG4108819 ferric iron reductase HJW98_RS22355 ENOG4105CK1 PTS System HJW98_RS22360 ENOG4108UIN ybak prolyl-trna synthetase associated region HJW98_RS22365 ENOG4108T94 DNA-binding transcriptional activator BglJ HJW98_RS22370 ENOG4108N8T regulatoR HJW98_RS22380 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HJW98_RS22385 ENOG4105DWK Membrane HJW98_RS22390 ENOG4107XM3 UPF0442 protein HJW98_RS22395 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HJW98_RS22400 ENOG4106CVF DNA replication protein HJW98_RS22405 ENOG4105RI1 glycoprotein receptor HJW98_RS22410 ENOG4107RES phosphoglycerol transferase I HJW98_RS22415 ENOG4105DNE Transposase HJW98_RS22430 ENOG4105F3R pts system mannose fructose sorbose family iid HJW98_RS22435 ENOG4105ETZ PTS System HJW98_RS22440 ENOG4105KPI PTS system sorbose subfamily IIB component HJW98_RS22450 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJW98_RS22460 ENOG4105XYF acetyltransferase HJW98_RS22465 ENOG4106KNT transcriptional regulator HJW98_RS22470 ENOG4108RTU Aldolase HJW98_RS22475 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HJW98_RS22505 ENOG4105DG4 malate L-lactate dehydrogenase HJW98_RS22520 ENOG4108V8F Transcriptional regulator, MarR family HJW98_RS22530 ENOG4105ERH Fumarylacetoacetate hydrolase HJW98_RS22540 ENOG4105C26 Dehydrogenase HJW98_RS22545 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HJW98_RS22560 ENOG4105CNV Aldolase HJW98_RS22570 ENOG4108NKV transcriptional regulator HJW98_RS22575 ENOG4105EFA 4-hydroxyphenylacetate HJW98_RS22580 ENOG4107UWN reductase HJW98_RS22585 ENOG4105CKT filamentous hemagglutinin HJW98_RS22595 ENOG4105CKT filamentous hemagglutinin HJW98_RS22600 ENOG4105D5K Hemolysin activator protein HJW98_RS22605 ENOG4105D22 carbon starvation protein HJW98_RS22610 ENOG4105VCD cytoplasmic protein HJW98_RS22615 ENOG4105CKI cobalamin synthesis protein HJW98_RS22625 ENOG4105C26 Dehydrogenase HJW98_RS22630 ENOG4105DNE Transposase HJW98_RS22635 ENOG4106AXJ AraC family transcriptional regulator HJW98_RS22645 ENOG4106BRA Membrane HJW98_RS22650 ENOG41083G8 Multidrug resistance protein MdtM HJW98_RS22660 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HJW98_RS22665 ENOG4105CIZ coA-substrate-specific enzyme activase HJW98_RS22680 ENOG4105EFX secretion protein, HlyD family HJW98_RS22690 ENOG4106DIZ Domain of unknown function (DUF1127) HJW98_RS22695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW98_RS22705 ENOG41064T2 transcriptional regulator, lysR family HJW98_RS22710 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HJW98_RS22730 ENOG4105KNY Microcompartments protein HJW98_RS22735 ENOG4105KNY Microcompartments protein HJW98_RS22740 ENOG4105KNY Microcompartments protein HJW98_RS22745 ENOG4105C0A alcohol dehydrogenase HJW98_RS22760 ENOG4105C6N Formate acetyltransferase HJW98_RS22765 ENOG4105F1A Pyruvate formate-lyase HJW98_RS22770 ENOG4105KNY Microcompartments protein HJW98_RS22775 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HJW98_RS22800 ENOG4105D0S secretion protein (HlyD HJW98_RS22805 ENOG4105CJ1 ABC, transporter HJW98_RS22810 ENOG4105CMI transporter HJW98_RS22840 ENOG4105EZE Cupin 4 family protein HJW98_RS22855 ENOG4105GR3 Histidine kinase HJW98_RS22860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJW98_RS22865 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJW98_RS22870 ENOG410624V efflux system protein HJW98_RS22875 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HJW98_RS22880 ENOG4108IJF Heavy metal efflux pump, CzcA HJW98_RS22890 ENOG4105QNF Outer membrane lipoprotein HJW98_RS22895 ENOG4108XDN Transcriptional regulator HJW98_RS22905 ENOG4107FW0 short-chain dehydrogenase reductase HJW98_RS22920 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HJW98_RS22940 ENOG4107SEY Conserved Protein HJW98_RS22945 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW98_RS22950 ENOG4105C93 Xylose Isomerase HJW98_RS22955 ENOG4105CT4 transporter HJW98_RS22960 ENOG4105DSG hydrolase family 43 HJW98_RS23030 ENOG41077A9 carbonic anhydrase HJW98_RS23035 ENOG4105CHH sulfate transporter HJW98_RS23040 ENOG4105DQ4 alcohol dehydrogenase HJW98_RS23050 ENOG4105DRS transport system, permease HJW98_RS23055 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HJW98_RS23060 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS23070 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HJW98_RS23075 ENOG4105F0H myo-inositol catabolism protein HJW98_RS23080 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HJW98_RS23085 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HJW98_RS23095 ENOG4105D7K pfkb domain protein HJW98_RS23100 ENOG4105CHC glucokinase (EC 2.7.1.2) HJW98_RS23105 ENOG4105DH8 myo-inositol catabolism HJW98_RS23110 ENOG4105C26 Dehydrogenase HJW98_RS23120 ENOG4105D7A ATP-binding protein HJW98_RS23125 ENOG4108K5H permease YjgP YjgQ family protein HJW98_RS23130 ENOG4108M8S permease YjgP YjgQ family protein HJW98_RS23135 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HJW98_RS23140 ENOG4105MYG DNA polymerase iii, chi subunit HJW98_RS23145 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HJW98_RS23150 ENOG4108MJ3 acetyltransferase HJW98_RS23155 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HJW98_RS23160 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HJW98_RS23170 ENOG4105XEP YhcH YjgK YiaL family protein HJW98_RS23180 ENOG4105CXT aspartate transcarbamylase HJW98_RS23185 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HJW98_RS23190 ENOG4105KME endoribonuclease L-psp HJW98_RS23200 ENOG4105D4X repressor HJW98_RS23205 ENOG4105C5Y PTS System HJW98_RS23210 ENOG4105CG3 alpha amylase, catalytic region HJW98_RS23215 ENOG4105CK1 PTS System HJW98_RS23220 ENOG4105F8D glycoside hydrolase family 4 HJW98_RS23240 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HJW98_RS23245 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HJW98_RS23250 ENOG4105K4U addiction module toxin, RelE StbE family HJW98_RS23260 ENOG4105EMD TRANSCRIPTIONal HJW98_RS23265 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HJW98_RS23280 ENOG41069H0 dihydroorotase EC 3.5.2.3 HJW98_RS23310 ENOG4108XVM Cytochrome b(562) HJW98_RS23315 ENOG4105CMS peptidase U62, modulator of DNA gyrase HJW98_RS23320 ENOG4105N42 UPF0307 protein HJW98_RS23340 ENOG4105DFU Cell wall formation (By similarity) HJW98_RS23345 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HJW98_RS23350 ENOG41062B0 ABC transporter, permease HJW98_RS23355 ENOG4107R9N ABC transporter HJW98_RS23360 ENOG4105C2J ABC transporter HJW98_RS23365 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HJW98_RS23370 ENOG4105F0N pyrophosphate phospho-hydrolase HJW98_RS23380 ENOG4108ZHD aig2 family HJW98_RS23385 ENOG4105MA0 exported protein HJW98_RS23390 ENOG4105CFU surface antigen HJW98_RS23400 ENOG4105C37 (CBS) domain HJW98_RS23410 ENOG4105C4C beta-galactosidase HJW98_RS23420 ENOG41061GZ Protein of unknown function (DUF1107) HJW98_RS23425 ENOG4108UUE Transcriptional regulator HJW98_RS23430 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HJW98_RS23435 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HJW98_RS23440 ENOG4105KVH Transcriptional regulator HJW98_RS23445 ENOG4105ECR NmrA family HJW98_RS23455 ENOG4105DXC membrane HJW98_RS23460 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HJW98_RS23470 ENOG4108V1T peptidylprolyl cis-trans isomerase HJW98_RS23475 ENOG4105FHY Opacity-associated protein A HJW98_RS23480 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HJW98_RS23485 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HJW98_RS23490 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HJW98_RS23495 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HJW98_RS23500 ENOG4105KIT UPF0379 protein yjfY HJW98_RS23525 ENOG4106ETB IIa component HJW98_RS23535 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HJW98_RS23550 ENOG4108MXZ Esterase HJW98_RS23555 ENOG4105WSB biofilm stress and motility protein A HJW98_RS23560 ENOG4105S17 UPF0379 protein yjfN HJW98_RS23565 ENOG4105CSU acyl-Coa dehydrogenase HJW98_RS23570 ENOG4105C2N RNA methyltransferase TrmH family group 3 HJW98_RS23575 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HJW98_RS23580 ENOG4105KPV Transcriptional regulator HJW98_RS23585 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HJW98_RS23600 ENOG4105EPW hflc protein HJW98_RS23605 ENOG4107QJR hflk protein HJW98_RS23610 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HJW98_RS23620 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HJW98_RS23625 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HJW98_RS23635 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HJW98_RS23640 ENOG4105K8N protein family UPF0079, ATPase HJW98_RS23645 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HJW98_RS23650 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HJW98_RS23670 ENOG4106TNF Periplasmic binding protein HJW98_RS23675 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HJW98_RS23680 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HJW98_RS23685 ENOG4105DJ4 phosphatidylserine decarboxylase HJW98_RS23690 ENOG4105EGS Mechanosensitive ion channel HJW98_RS23695 ENOG4107SC7 Inner membrane transporter yjeM HJW98_RS23700 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HJW98_RS23705 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HJW98_RS23710 ENOG4105E33 succinate dehydrogenase HJW98_RS23720 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HJW98_RS23730 ENOG4105KPY Small multidrug resistance protein HJW98_RS23735 ENOG4106BSU Entericidin B HJW98_RS23745 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HJW98_RS23750 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HJW98_RS23775 ENOG4105CW0 outer membrane usher protein HJW98_RS23790 ENOG4108MBX Secretion Protein HJW98_RS23795 ENOG4108JJA ABC, transporter HJW98_RS23805 ENOG4108ZVF (LipO)protein HJW98_RS23810 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HJW98_RS23820 ENOG4105DVH amino acid HJW98_RS23825 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HJW98_RS23830 ENOG4108IJ0 Aspartate ammonia-lyase HJW98_RS23835 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HJW98_RS23845 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HJW98_RS23850 ENOG4108SIC Transcriptional regulator HJW98_RS23885 ENOG4108TUY outer membrane protein PgaA HJW98_RS23890 ENOG4107BJW polysaccharide deacetylase HJW98_RS23895 ENOG4105CND Glycosyl transferase, family 2 HJW98_RS23915 ENOG4108ZCF integral membrane protein HJW98_RS23925 ENOG4105DVC DnaJ domain protein HJW98_RS23950 ENOG4105CT4 transporter HJW98_RS23955 ENOG4105F8D glycoside hydrolase family 4 HJW98_RS23960 ENOG4108K2B transcriptional regulator HJW98_RS23965 ENOG4105CSH Transporter HJW98_RS23970 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HJW98_RS23975 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HJW98_RS23980 ENOG4107RJJ Transcriptional regulator HJW98_RS23985 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HJW98_RS23990 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HJW98_RS23995 ENOG4105EKV Phosphonate metabolism protein HJW98_RS24000 ENOG4105FT8 Phosphonate metabolism HJW98_RS24005 ENOG4105ENV phosphonate C-P lyase system protein PhnK HJW98_RS24010 ENOG4105HRV phosphonate c-p lyase system protein phnl HJW98_RS24015 ENOG4105FD8 phosphonate metabolism protein PhnM HJW98_RS24020 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HJW98_RS24025 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HJW98_RS24035 ENOG4105BZU Histidine kinase HJW98_RS24040 ENOG4105C2J ABC transporter HJW98_RS24045 ENOG4105CNN ABC, transporter HJW98_RS24050 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJW98_RS24085 ENOG41082ND Uncharacterized protein yjcO HJW98_RS24090 ENOG4105CK2 sodium dicarboxylate symporter HJW98_RS24100 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HJW98_RS24105 ENOG41062QD Membrane HJW98_RS24110 ENOG4107QN1 sodium solute HJW98_RS24125 ENOG4105CW0 outer membrane usher protein HJW98_RS24130 ENOG4108VCD Chaperone HJW98_RS24135 ENOG4105MX3 Fimbrial HJW98_RS24145 ENOG41067MG lrgb family HJW98_RS24155 ENOG4105CMU LysR family (Transcriptional regulator HJW98_RS24160 ENOG4105EEQ Na H antiporter HJW98_RS24165 ENOG4105C7N Xanthine uracil vitamin C permease HJW98_RS24170 ENOG4108K3A Glutathione S-transferase HJW98_RS24175 ENOG4108Z4X TRANSCRIPTIONal HJW98_RS24180 ENOG4108W3Q Transcriptional regulator HJW98_RS24185 ENOG4108M8H domain protein HJW98_RS24190 ENOG4105PMV Membrane HJW98_RS24215 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HJW98_RS24220 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS24225 ENOG4105ECY inositol monophosphatase HJW98_RS24235 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJW98_RS24255 ENOG4108DMH HTH_ARAC HJW98_RS24260 ENOG4107RNH Outer membrane receptor FepA HJW98_RS24270 ENOG4105E4C Lytic transglycosylase catalytic HJW98_RS24275 ENOG4108UUM single-stranded DNA-binding protein HJW98_RS24280 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HJW98_RS24285 ENOG4105MSB protein, conserved in bacteria HJW98_RS24290 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HJW98_RS24300 ENOG4105CGF Aromatic amino acid aminotransferase HJW98_RS24305 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HJW98_RS24310 ENOG4105CDU Replicative dna helicase HJW98_RS24315 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HJW98_RS24320 ENOG4105P4Z Phage shock protein G HJW98_RS24325 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HJW98_RS24335 ENOG4105MYN Zinc uptake regulation protein HJW98_RS24340 ENOG4105VDW Csbd family HJW98_RS24350 ENOG4107R73 Mate efflux family protein HJW98_RS24355 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HJW98_RS24360 ENOG41080IJ Diacylglycerol kinase HJW98_RS24365 ENOG4105E55 glycerol-3-phosphate acyltransferase HJW98_RS24370 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HJW98_RS24375 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HJW98_RS24380 ENOG4107W52 maltose operon periplasmic protein HJW98_RS24385 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW98_RS24390 ENOG4108IJ9 (ABC) transporter HJW98_RS24395 ENOG4107FKK extracellular solute-binding protein family 1 HJW98_RS24400 ENOG4105D56 permease protein HJW98_RS24405 ENOG4105EG2 ABC transporter, permease HJW98_RS24410 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HJW98_RS24415 ENOG4105CEM UPF0597 protein HJW98_RS24430 ENOG4105KME endoribonuclease L-psp HJW98_RS24440 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HJW98_RS24445 ENOG4107QP8 phosphohexose isomerase HJW98_RS24450 ENOG4105CFH Aspartokinase HJW98_RS24455 ENOG4105C09 Bile acid HJW98_RS24460 ENOG4108ZR5 Conserved Protein HJW98_RS24465 ENOG4105FE9 pseudouridine synthase HJW98_RS24470 ENOG4105DKT Transcriptional regulator HJW98_RS24475 ENOG4105CHR reductase HJW98_RS24480 ENOG4108XCU pts system HJW98_RS24485 ENOG4105KPI PTS system sorbose subfamily IIB component HJW98_RS24490 ENOG4105ETZ PTS System HJW98_RS24495 ENOG4105F3R pts system mannose fructose sorbose family iid HJW98_RS24500 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HJW98_RS24505 ENOG4105F9E Shikimate 5-dehydrogenase HJW98_RS24510 ENOG4105EAM Na Pi-cotransporter HJW98_RS24515 ENOG4105C3R Methionine synthase HJW98_RS24520 ENOG41069M3 Transcriptional regulator HJW98_RS24525 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HJW98_RS24530 ENOG4108I9X Isocitrate lyase HJW98_RS24535 ENOG4107QP3 malate synthase g HJW98_RS24540 ENOG4105CVG Homoserine O-transsuccinylase HJW98_RS24545 ENOG4105K5X acetyltransferase HJW98_RS24570 ENOG4105DC1 bifunctional purine biosynthesis protein purh HJW98_RS24575 ENOG4105C12 Phosphoribosylglycinamide synthetase HJW98_RS24585 ENOG4105BZU Histidine kinase HJW98_RS24590 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HJW98_RS24595 ENOG4108T8B Protein of unknown function (DUF1481) HJW98_RS24600 ENOG4105K70 DNA-binding protein HJW98_RS24605 ENOG4105R2J Conserved Protein HJW98_RS24610 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HJW98_RS24615 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HJW98_RS24620 ENOG4105E09 nadh pyrophosphatase HJW98_RS24625 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HJW98_RS24630 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HJW98_RS24635 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HJW98_RS24640 ENOG4105D06 uba thif-type nad fad binding protein HJW98_RS24645 ENOG4105WHD thiamine biosynthesis protein ThiS HJW98_RS24650 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HJW98_RS24655 ENOG4105D41 biosynthesis protein thiH HJW98_RS24660 ENOG4106TD9 Diguanylate cyclase HJW98_RS24670 ENOG4105VCP PTS System HJW98_RS24675 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HJW98_RS24680 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJW98_RS24685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJW98_RS24690 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HJW98_RS24695 ENOG4108VZM 50s ribosomal protein L10 HJW98_RS24700 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HJW98_RS24705 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HJW98_RS24710 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HJW98_RS24715 ENOG4105PM1 preprotein translocase subunit SecE HJW98_RS24720 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HJW98_RS24745 ENOG4105CS9 pantothenic acid kinase HJW98_RS24750 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HJW98_RS24755 ENOG4105D4A Cell wall formation (By similarity) HJW98_RS24785 ENOG4108RR8 protoporphyrinogen oxidase HJW98_RS24790 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HJW98_RS24795 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HJW98_RS24800 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HJW98_RS24805 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) HJW98_RS24810 ENOG4105CHU acetyl-coa acetyltransferase HJW98_RS24815 ENOG4107QK7 reductase HJW98_RS24820 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJW98_RS24830 ENOG4105MDZ Transcriptional activator rfaH HJW98_RS24840 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HJW98_RS24845 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HJW98_RS24850 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HJW98_RS24855 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HJW98_RS24860 ENOG4105JC1 sterol-binding domain protein HJW98_RS24865 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HJW98_RS24870 ENOG4105CGY Dna recombination protein HJW98_RS24875 ENOG4107SXA Phosphorylase HJW98_RS24880 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HJW98_RS24885 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HJW98_RS24890 ENOG4105DZ2 Transcriptional regulator HJW98_RS24895 ENOG4105EMK carboxylate amino acid amine transporter HJW98_RS24900 ENOG4105DQF Hydrolase HJW98_RS24905 ENOG4108EUD Lysophospholipase HJW98_RS24910 ENOG410829K Lysine exporter protein (Lyse ygga) HJW98_RS24920 ENOG4105CCF Lysine exporter protein (Lyse ygga) HJW98_RS24925 ENOG4105C9U ATP-dependent DNA helicase RecQ HJW98_RS24930 ENOG4105HDD phospholipase HJW98_RS24935 ENOG4108VUY thioesterase Superfamily protein HJW98_RS24940 ENOG4105FR1 rard protein HJW98_RS24945 ENOG4107QUT magnesium and cobalt transport protein CorA HJW98_RS24950 ENOG4105C4R Atp-dependent dna helicase HJW98_RS24955 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HJW98_RS24960 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJW98_RS24965 ENOG4105CT0 Protein of unknown function, DUF484 HJW98_RS24975 ENOG4105S7Z (LipO)protein HJW98_RS24980 ENOG4105XQ6 frataxin-like protein HJW98_RS24985 ENOG4107T0K Adenylate cyclase HJW98_RS24990 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HJW98_RS24995 ENOG41076E6 Uroporphyrinogen-III Synthase HJW98_RS25000 ENOG4105ECF c-methyltransferase HJW98_RS25005 ENOG410601J HemY protein HJW98_RS25035 ENOG4105C85 amino acid HJW98_RS25040 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HJW98_RS25045 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HJW98_RS25050 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HJW98_RS25055 ENOG4105EGZ biosynthesis protein HJW98_RS25060 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HJW98_RS25065 ENOG4108WJ1 acetyltransferase HJW98_RS25070 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HJW98_RS25075 ENOG4105C1B dTDP-glucose 4-6-dehydratase HJW98_RS25080 ENOG4107QQG Dehydrogenase HJW98_RS25085 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HJW98_RS25090 ENOG4105SFE lipopolysaccharide biosynthesis protein HJW98_RS25095 ENOG4105ESV Glycosyl transferase, family 4 HJW98_RS25100 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HJW98_RS25110 ENOG4105C1J atp-dependent rna helicase HJW98_RS25115 ENOG4105C9X ppx gppa phosphatase HJW98_RS25130 ENOG4108UQV Membrane HJW98_RS25135 ENOG4105C4R Atp-dependent dna helicase HJW98_RS25140 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HJW98_RS25145 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HJW98_RS25150 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HJW98_RS25155 ENOG4105EMY transcriptional regulator HJW98_RS25160 ENOG4105C7B Threonine dehydratase HJW98_RS25165 ENOG4105C01 Dihydroxy-acid dehydratase HJW98_RS25170 ENOG4105CM2 brancheD-chain amino acid aminotransferase HJW98_RS25175 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HJW98_RS25190 ENOG4105C0P Mg chelatase subunit ChlI HJW98_RS25195 ENOG4108WFC UPF0438 protein yifE HJW98_RS25250 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HJW98_RS25255 ENOG4108Y73 Membrane HJW98_RS25260 ENOG4105EJ2 Transcriptional regulator HJW98_RS25265 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HJW98_RS25270 ENOG4105C5Q Transcriptional regulator HJW98_RS25275 ENOG4105CH7 arginosuccinase HJW98_RS25280 ENOG4105CAS nag kinase HJW98_RS25285 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HJW98_RS25300 ENOG4108MEK Metal-binding protein YodA HJW98_RS25305 ENOG4106R3P AraC family transcriptional regulator HJW98_RS25310 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW98_RS25315 ENOG4105DCT glycerol dehydrogenase HJW98_RS25320 ENOG4108Q5Y Membrane HJW98_RS25325 ENOG4105SYT Methylenetetrahydrofolate reductase HJW98_RS25330 ENOG4105CN8 Transcriptional regulator HJW98_RS25335 ENOG4108Z8I decarboxylase HJW98_RS25340 ENOG4105CGH 5'-nucleotidase HJW98_RS25350 ENOG4105CFH Aspartokinase HJW98_RS25355 ENOG4105C28 cystathionine HJW98_RS25360 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HJW98_RS25365 ENOG4105VFB Binds the 23S rRNA (By similarity) HJW98_RS25370 ENOG4105C25 Primosomal protein n' HJW98_RS25375 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS25380 ENOG41063M6 Cell Division Protein HJW98_RS25385 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HJW98_RS25395 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HJW98_RS25400 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HJW98_RS25405 ENOG4105CTQ phosphohexokinase HJW98_RS25410 ENOG41076HS cation diffusion facilitator family transporter HJW98_RS25415 ENOG4105FMW periplasmic HJW98_RS25420 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJW98_RS25425 ENOG4105E0F Histidine kinase HJW98_RS25430 ENOG4108RPX mosc domain containing protein HJW98_RS25435 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJW98_RS25440 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HJW98_RS25445 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HJW98_RS25450 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HJW98_RS25455 ENOG4105DET Rhamnulokinase HJW98_RS25460 ENOG4105DKG l-rhamnose isomerase HJW98_RS25465 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HJW98_RS25470 ENOG4105D4B ABC, transporter HJW98_RS25475 ENOG4105C2J ABC transporter HJW98_RS25480 ENOG4105CNN ABC, transporter HJW98_RS25485 ENOG4105CNN ABC, transporter HJW98_RS25490 ENOG4105C0A alcohol dehydrogenase HJW98_RS25500 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW98_RS25535 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HJW98_RS25545 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HJW98_RS25550 ENOG4108MG3 formate dehydrogenase HJW98_RS25555 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HJW98_RS25565 ENOG41068KX affects formate dehydrogenase-N HJW98_RS25575 ENOG4105SUU thioesterase domain HJW98_RS25580 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HJW98_RS25585 ENOG4107S2Z UPF0761 membrane protein HJW98_RS25590 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HJW98_RS25595 ENOG4105CI3 gtp-binding protein typa HJW98_RS25600 ENOG4105C5F glutamine synthetase HJW98_RS25605 ENOG4105CUX Signal transduction histidine kinase HJW98_RS25610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJW98_RS25615 ENOG4106FIY HJW98_RS25620 ENOG4105D4P Coproporphyrinogen iii oxidase HJW98_RS25625 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HJW98_RS25630 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HJW98_RS25635 ENOG4105C2M dna polymerase I HJW98_RS25640 ENOG4106HNH Acyl-transferase HJW98_RS25645 ENOG4108Z33 Thiol disulfide Interchange Protein HJW98_RS25650 ENOG4105E27 serine threonine protein kinase HJW98_RS25655 ENOG4105PC1 Conserved Protein HJW98_RS25660 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HJW98_RS25665 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HJW98_RS25690 ENOG4107EJG GntR family transcriptional regulator HJW98_RS25695 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW98_RS25700 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS25705 ENOG4108RVA ribokinase HJW98_RS25710 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJW98_RS25715 ENOG4105CNN ABC, transporter HJW98_RS25720 ENOG4105C2J ABC transporter HJW98_RS25730 ENOG4105DFH Transport of potassium into the cell (By similarity) HJW98_RS25745 ENOG4105CU9 asparagine synthetase A HJW98_RS25750 ENOG4108VVK transcriptional Regulator, AsnC HJW98_RS25755 ENOG4105QTB Flavodoxin HJW98_RS25760 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HJW98_RS25765 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HJW98_RS25770 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HJW98_RS25790 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HJW98_RS25795 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HJW98_RS25800 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HJW98_RS25805 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HJW98_RS25810 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HJW98_RS25830 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HJW98_RS25835 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HJW98_RS25840 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HJW98_RS25845 ENOG4105C8U phosphate abc transporter HJW98_RS25850 ENOG4105E2Z phosphate ABC transporter (Permease HJW98_RS25855 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HJW98_RS25875 ENOG4105DYC esterase HJW98_RS25880 ENOG4107VKM 6-phosphogluconolactonase HJW98_RS25885 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HJW98_RS25895 ENOG4105C7N Xanthine uracil vitamin C permease HJW98_RS25900 ENOG4108YYH Nadph-dependent fmn reductase HJW98_RS25905 ENOG4105E8Q phosphopantetheinyl transferase HJW98_RS25915 ENOG4105C2C drug resistance transporter, Bcr CflA HJW98_RS25925 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HJW98_RS25930 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HJW98_RS25935 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HJW98_RS25945 ENOG4105VG0 50S ribosomal protein l34 HJW98_RS25960 ENOG410620I Diguanylate cyclase HJW98_RS25980 ENOG4108M8H domain protein HJW98_RS25990 ENOG4105C94 Transporter HJW98_RS26035 ENOG410624V efflux system protein HJW98_RS26065 ENOG4105DR5 peptidase HJW98_RS26075 ENOG4105E3B Multicopper oxidase HJW98_RS26080 ENOG4105VR0 copper resistance HJW98_RS26085 ENOG4105JDN Copper resistance protein HJW98_RS26090 ENOG4108PG2 copper resistance HJW98_RS26095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJW98_RS26100 ENOG4105GR3 Histidine kinase HJW98_RS26135 ENOG4105KF5 hemolysin expression-modulating protein HJW98_RS26150 ENOG4105CXG d-lactate dehydrogenase HJW98_RS26155 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HJW98_RS26160 ENOG4107QR9 Iron-sulfur cluster binding protein HJW98_RS26165 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HJW98_RS26175 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HJW98_RS26250 ENOG4105C87 Aminotransferase class I and II HJW98_RS26255 ENOG4105CHR reductase HJW98_RS26260 ENOG4107ZXU DSBA oxidoreductase HJW98_RS26265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJW98_RS26295 ENOG4108BUD transposase HJW98_RS26300 ENOG4105EQR Transposase IS116 IS110 IS902 HJW98_RS26325 ENOG4105KF5 hemolysin expression-modulating protein HJW98_RS26350 ENOG4108YGG dna repair protein HJW98_RS26435 ENOG4108KTG Membrane protein, drug metabolite transporter HJW98_RS26480 ENOG4108BUD transposase HJW98_RS26490 ENOG4108C33 Resolvase HJW98_RS26495 ENOG4108BUD transposase HJW98_RS26545 ENOG4105CJN penicillin-binding protein HJW98_RS26550 ENOG4108BUD transposase HJW98_RS26570 ENOG4105I1F Resistance protein HJW98_RS26590 ENOG4108BUD transposase HJW98_RS26605 ENOG4105G63 Type III effector Hrp-dependent HJW98_RS26610 ENOG4105FB2 class II Aldolase HJW98_RS26620 ENOG4108BUD transposase HJW98_RS26655 ENOG4108JQ6 ABC transporter HJW98_RS26670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW98_RS26675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW98_RS26700 ENOG4108SF5 RNA Polymerase HJW98_RS26705 ENOG4108S3W Anti-feci sigma factor, fecr HJW98_RS26710 ENOG4105GAV receptor HJW98_RS26715 ENOG4108HUF Transporter HJW98_RS26720 ENOG4105DQ5 transport system permease protein HJW98_RS26725 ENOG4108IHU transport system permease protein HJW98_RS26730 ENOG4105E0A ABC, transporter HJW98_RS26735 ENOG4108YXQ IS66 Orf2 family protein HJW98_RS26750 ENOG4105EQR Transposase IS116 IS110 IS902 HJW98_RS26755 ENOG4105ETE Transcriptional regulator (LacI family HJW98_RS26765 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW98_RS26820 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HJW98_RS26830 ENOG4105WPN DNA integration recombination invertion protein HJW98_RS26895 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HJW98_RS26925 ENOG4107CBI conjugal transfer fertility inhibition protein HJW98_RS27190 ENOG4105EKQ RNA-directed DNA polymerase