locus-tag class description HJX47_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HJX47_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HJX47_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJX47_RS00025 ENOG410667J hydrolase HJX47_RS00040 ENOG4105EMF GntR family transcriptional regulator HJX47_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HJX47_RS00050 ENOG4108RTU Aldolase HJX47_RS00055 ENOG4105CXK mandelate racemase muconate lactonizing HJX47_RS00060 ENOG4105DJB Major Facilitator Superfamily HJX47_RS00065 ENOG4105D99 atp gtp-binding protein HJX47_RS00070 ENOG4105R2A (LipO)protein HJX47_RS00090 ENOG4105D0C transport protein HJX47_RS00095 ENOG4105FDP GntR family transcriptional regulator HJX47_RS00100 ENOG4105CI1 PTS System HJX47_RS00105 ENOG4105F8D glycoside hydrolase family 4 HJX47_RS00110 ENOG4105VG5 Membrane HJX47_RS00115 ENOG4105JP4 Inner membrane protein yidG HJX47_RS00140 ENOG4105W8I Transcriptional regulator HJX47_RS00145 ENOG4105E5M Multidrug resistance protein D HJX47_RS00175 ENOG4105C7K acetolactate synthase HJX47_RS00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit HJX47_RS00185 ENOG4108KX4 response regulator HJX47_RS00190 ENOG4105BZU Histidine kinase HJX47_RS00195 ENOG4105CXY transporter HJX47_RS00200 ENOG4105CXY transporter HJX47_RS00205 ENOG4108SAJ Protein of unknown function (DUF1198) HJX47_RS00225 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HJX47_RS00230 ENOG4107STF Involved in phosphonate degradation (By similarity) HJX47_RS00235 ENOG4106S9K Transcriptional regulator HJX47_RS00250 ENOG4108MP3 ABC transporter, permease HJX47_RS00260 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJX47_RS00265 ENOG4105VCP PTS System HJX47_RS00270 ENOG4105CK1 PTS System HJX47_RS00280 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS00285 ENOG4105D2S major facilitator superfamily HJX47_RS00295 ENOG4107F9Y LysR family transcriptional regulator HJX47_RS00305 ENOG4105JSC dimethylmenaquinone methyltransferase HJX47_RS00320 ENOG4105T8A Uncharacterized protein YicS HJX47_RS00325 ENOG4108UZ3 Transporter HJX47_RS00330 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HJX47_RS00335 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HJX47_RS00340 ENOG4105C2C drug resistance transporter, Bcr CflA HJX47_RS00345 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJX47_RS00350 ENOG4105BZS acriflavin resistance protein HJX47_RS00355 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJX47_RS00375 ENOG410630P Transcriptional regulator HJX47_RS00385 ENOG4105CR8 Transcriptional regulator HJX47_RS00410 ENOG4105D01 (LipO)protein HJX47_RS00425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HJX47_RS00435 ENOG4105DQ4 alcohol dehydrogenase HJX47_RS00455 ENOG4105NI3 Protein of unknown function (DUF3237) HJX47_RS00495 ENOG4105CT4 transporter HJX47_RS00500 ENOG4105CJQ hydrolase, family 31 HJX47_RS00510 ENOG4105F8D glycoside hydrolase family 4 HJX47_RS00515 ENOG4105CI1 PTS System HJX47_RS00520 ENOG4105JV1 AsmA family HJX47_RS00525 ENOG4105C2W permease HJX47_RS00530 ENOG4105D6U Sodium Glutamate Symporter HJX47_RS00535 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HJX47_RS00540 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJX47_RS00545 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HJX47_RS00550 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HJX47_RS00565 ENOG4105CP7 Triose-phosphate isomerase HJX47_RS00570 ENOG4105EBK exported protein HJX47_RS00575 ENOG4108VTS Membrane HJX47_RS00580 ENOG4105DP0 ferredoxin-NADP reductase HJX47_RS00585 ENOG4105CBT Fructose-1,6-bisphosphatase HJX47_RS00590 ENOG4105CB5 ATP-dependent DNA helicase recG HJX47_RS00595 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HJX47_RS00600 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HJX47_RS00610 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HJX47_RS00615 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HJX47_RS00620 ENOG4105EN6 Membrane HJX47_RS00630 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJX47_RS00645 ENOG4105DSJ YicC domain protein HJX47_RS00670 ENOG4105CJ1 ABC, transporter HJX47_RS00675 ENOG4107QWP ABC-2 type transporter HJX47_RS00680 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HJX47_RS00690 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HJX47_RS00695 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HJX47_RS00700 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HJX47_RS00705 ENOG4105W5Q DNA repair protein (RadC HJX47_RS00710 ENOG4105KDC 50s ribosomal protein l28 HJX47_RS00715 ENOG4105W0E 50S ribosomal protein L33 HJX47_RS00720 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HJX47_RS00725 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HJX47_RS00730 ENOG4106WTF Glycosyl transferase, family 2 HJX47_RS00735 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HJX47_RS00740 ENOG4105K64 Glycosyl transferase, family 2 HJX47_RS00745 ENOG4105CPK Glycosyl transferase (Group 1 HJX47_RS00755 ENOG4105DKP glycosyl transferase, family 9 HJX47_RS00780 ENOG4105D16 lipopolysaccharide heptosyltransferase i HJX47_RS00785 ENOG4105XA0 heptosyltransferase ii HJX47_RS00790 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HJX47_RS00795 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HJX47_RS00800 ENOG4105CPQ Dehydrogenase HJX47_RS00805 ENOG4106WTF Glycosyl transferase, family 2 HJX47_RS00810 ENOG4105PXI polysaccharide deacetylase HJX47_RS00815 ENOG41063SB peptidase HJX47_RS00825 ENOG4107YZP Rhodanese domain protein HJX47_RS00830 ENOG4105VW4 glutaredoxin 3 HJX47_RS00835 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HJX47_RS00840 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HJX47_RS00845 ENOG4105D7W serine acetyltransferase HJX47_RS00850 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HJX47_RS00855 ENOG4105DMF Dehydrogenase HJX47_RS00860 ENOG41073TP transcriptional regulator HJX47_RS00865 ENOG4105DAA L-lactate HJX47_RS00870 ENOG4108YYI Protein of unknown function (DUF2810) HJX47_RS00880 ENOG4105E61 Mannitol repressor protein HJX47_RS00885 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HJX47_RS00890 ENOG4105CTS PTS system mannitol-specific HJX47_RS00895 ENOG4105FP6 Protein of unknown function (DUF3302) HJX47_RS00900 ENOG4105EFX secretion protein, HlyD family HJX47_RS00905 ENOG4108U78 Glutathione S-transferase HJX47_RS00910 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HJX47_RS00915 ENOG4105EM7 Selenocysteine-specific translation elongation factor HJX47_RS00920 ENOG4105J4Q Transcriptional regulator HJX47_RS00925 ENOG4108RC0 Electron transport protein HJX47_RS00930 ENOG4105JKW Valine--pyruvate aminotransferase HJX47_RS00935 ENOG4107T9C Alpha amylase catalytic region HJX47_RS00940 ENOG4108UR8 BAX protein HJX47_RS00945 ENOG4105T16 Transcriptional regulator (AraC family) HJX47_RS00950 ENOG4108HWW ABC transporter HJX47_RS00960 ENOG4105DFW ABC transporter HJX47_RS00965 ENOG4105C93 Xylose Isomerase HJX47_RS00970 ENOG4105CMG Carbohydrate kinase HJX47_RS00975 ENOG410688U Inner membrane protein yiaB HJX47_RS00980 ENOG4108Z12 YiaAB two helix domain-containing protein HJX47_RS00985 ENOG4105MEV Acyl-transferase HJX47_RS00995 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HJX47_RS01000 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HJX47_RS01005 ENOG41060TC Hok gef cell toxic protein HJX47_RS01020 ENOG4105MVF Transcriptional regulator HJX47_RS01025 ENOG4105D2S major facilitator superfamily HJX47_RS01030 ENOG4106JH6 (LipO)protein HJX47_RS01035 ENOG4105C5I Dehydrogenase HJX47_RS01045 ENOG4105D7K pfkb domain protein HJX47_RS01055 ENOG4108M60 Transcriptional regulator HJX47_RS01065 ENOG4108ZG0 Ompa motb domain protein HJX47_RS01070 ENOG4107QY8 reductase HJX47_RS01075 ENOG4105HNP -acetyltransferase HJX47_RS01080 ENOG4108R3E Dna-3-methyladenine glycosylase i HJX47_RS01085 ENOG4105EAX Putative lipase HJX47_RS01090 ENOG4105FCD Major Facilitator HJX47_RS01095 ENOG4105DIJ Phosphoethanolamine transferase HJX47_RS01115 ENOG4105DEF Extracellular solute-binding protein, family 5 HJX47_RS01120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJX47_RS01125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJX47_RS01130 ENOG4105C3U ABC transporter HJX47_RS01135 ENOG4108JQ7 (ABC) transporter HJX47_RS01150 ENOG4107U53 septum site-determining protein minD HJX47_RS01155 ENOG4107QZ7 Cellulose synthase catalytic subunit HJX47_RS01160 ENOG4107EEX Cellulose synthase regulator protein HJX47_RS01165 ENOG4105EJG cellulose synthase HJX47_RS01180 ENOG4105D1V cellulose synthase operon protein YhjU HJX47_RS01185 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HJX47_RS01190 ENOG4105U74 cellulose biosynthesis protein BcsE HJX47_RS01195 ENOG410661M cytoplasmic protein HJX47_RS01200 ENOG4105UTS cellulose synthase operon protein YhjQ HJX47_RS01205 ENOG4107QZ7 Cellulose synthase catalytic subunit HJX47_RS01210 ENOG4107EEX Cellulose synthase regulator protein HJX47_RS01215 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HJX47_RS01220 ENOG4105EJG cellulose synthase HJX47_RS01225 ENOG4105BZU Histidine kinase HJX47_RS01230 ENOG4105CK2 sodium dicarboxylate symporter HJX47_RS01235 ENOG4105CS0 peptidase HJX47_RS01250 ENOG41066T0 asmA family HJX47_RS01255 ENOG4105CSH Transporter HJX47_RS01260 ENOG4107H3J ribonuclease HJX47_RS01265 ENOG4105CBN LysR family transcriptional regulator HJX47_RS01270 ENOG4105CHR reductase HJX47_RS01285 ENOG4105C0A alcohol dehydrogenase HJX47_RS01295 ENOG4105DC8 reductase HJX47_RS01300 ENOG4105D6S protein involved in catabolism of external DNA HJX47_RS01305 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HJX47_RS01310 ENOG4105DGW oligopeptidase A HJX47_RS01315 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HJX47_RS01320 ENOG4105DUX Transporter HJX47_RS01330 ENOG4108V6B universal stress protein B HJX47_RS01335 ENOG4105CJ3 phosphate transporter HJX47_RS01340 ENOG4105CBX hi0933 family HJX47_RS01345 ENOG4105CJW magnesium transporter HJX47_RS01355 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS01365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJX47_RS01370 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJX47_RS01375 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HJX47_RS01385 ENOG4105PY6 Phenolic acid decarboxylase HJX47_RS01390 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HJX47_RS01395 ENOG4105CKK Glycosyl transferase, family 2 HJX47_RS01400 ENOG4105C3I Nad-dependent epimerase dehydratase HJX47_RS01405 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HJX47_RS01410 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HJX47_RS01415 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HJX47_RS01420 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HJX47_RS01425 ENOG4105DSF transport protein HJX47_RS01430 ENOG4105F9N Major Facilitator Superfamily HJX47_RS01435 ENOG4108W1V Lipoprotein HJX47_RS01440 ENOG4105EX9 Membrane HJX47_RS01445 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HJX47_RS01455 ENOG4107FS9 Membrane HJX47_RS01465 ENOG4105MG3 Membrane HJX47_RS01470 ENOG4106H78 methyltransferase HJX47_RS01475 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HJX47_RS01480 ENOG4105CAK Cell division ATP-binding protein ftsE HJX47_RS01485 ENOG4105CRP Part of the ABC transporter FtsEX involved in HJX47_RS01500 ENOG4108JPW Aminotransferase HJX47_RS01510 ENOG4105CP9 extracellular ligand-binding receptor HJX47_RS01515 ENOG4105U59 -acetyltransferase HJX47_RS01520 ENOG4105CP9 extracellular ligand-binding receptor HJX47_RS01525 ENOG4105C32 Amino acid ABC transporter (Permease) HJX47_RS01530 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJX47_RS01535 ENOG4105C0Z ABC transporter HJX47_RS01540 ENOG4108IV0 ABC, transporter HJX47_RS01545 ENOG41060M8 Pfam:PhdYeFM HJX47_RS01555 ENOG4105BZ7 extracellular solute-binding protein family 1 HJX47_RS01560 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HJX47_RS01575 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HJX47_RS01580 ENOG4105WC8 Conserved Protein HJX47_RS01585 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HJX47_RS01590 ENOG4105WCN acetyltransferase HJX47_RS01600 ENOG4105D9R oxidoreductase HJX47_RS01605 ENOG4105C2I pirin domain protein HJX47_RS01610 ENOG4105DIQ Transcriptional regulator HJX47_RS01615 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HJX47_RS01620 ENOG4105C6Z Gluconate HJX47_RS01630 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJX47_RS01635 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HJX47_RS01640 ENOG4108IUM Glycogen debranching enzyme HJX47_RS01645 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HJX47_RS01655 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HJX47_RS01670 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HJX47_RS01675 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HJX47_RS01680 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HJX47_RS01685 ENOG4105E98 transcriptional regulator DeoR family HJX47_RS01690 ENOG41061ZR Transcriptional regulator HJX47_RS01695 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HJX47_RS01700 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HJX47_RS01705 ENOG4105C6Z Gluconate HJX47_RS01710 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HJX47_RS01715 ENOG4105MJ2 Competence protein HJX47_RS01720 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HJX47_RS01730 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HJX47_RS01735 ENOG4105CE1 Ferrous iron transport protein b HJX47_RS01740 ENOG4105XFK Ferrous iron transport protein A HJX47_RS01745 ENOG4105BZM domain protein HJX47_RS01750 ENOG4108RRZ Transcription elongation factor GreB HJX47_RS01760 ENOG4105E0F Histidine kinase HJX47_RS01765 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HJX47_RS01775 ENOG4105VEJ Heat shock protein HJX47_RS01780 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HJX47_RS01785 ENOG4105DQY intracellular growth attenuator HJX47_RS01790 ENOG4107RK2 ADP-ribose diphosphatase NudE HJX47_RS01795 ENOG4108JQC penicillin-binding protein 1A HJX47_RS01820 ENOG4105E4G Type IV pilus HJX47_RS01825 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HJX47_RS01830 ENOG4105D49 3-dehydroquinate synthase HJX47_RS01835 ENOG4105EGB membrane protein DamX HJX47_RS01840 ENOG4105DFE Dna adenine methylase HJX47_RS01845 ENOG4105DJV ribulose-phosphate 3-epimerase HJX47_RS01855 ENOG4105C31 Tryptophanyl-tRNA synthetase HJX47_RS01860 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HJX47_RS01865 ENOG4105WZK nitrite reductase NADPH small subunit HJX47_RS01870 ENOG4107QZF nitrite reductase NADPH large subunit HJX47_RS01880 ENOG4105DZC cytosine deaminase HJX47_RS01885 ENOG4106DTQ Protein TsgA homolog HJX47_RS01890 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HJX47_RS01895 ENOG4106195 uncharacterized protein yhfG HJX47_RS01900 ENOG4105MZU cell filamentation protein HJX47_RS01910 ENOG4105C8Y Acetylornithine aminotransferase HJX47_RS01915 ENOG410613R integral membrane protein, YccS YhfK family HJX47_RS01920 ENOG4107RYR Transcriptional regulator, Crp Fnr family HJX47_RS01925 ENOG4108UKZ OsmC family HJX47_RS01930 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HJX47_RS01940 ENOG4105DNZ Alpha Beta Hydrolase HJX47_RS01950 ENOG4105C5H ABC transporter HJX47_RS01955 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HJX47_RS01960 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJX47_RS01965 ENOG4105VKU nucleicacid-binding protein HJX47_RS01970 ENOG4108YZY peptidylprolyl cis-trans isomerase HJX47_RS01975 ENOG4105VRX Protein slyX homolog HJX47_RS01980 ENOG4108V1T peptidylprolyl cis-trans isomerase HJX47_RS01985 ENOG4105WWK YheO domain protein HJX47_RS01990 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HJX47_RS01995 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HJX47_RS02000 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HJX47_RS02005 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HJX47_RS02010 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HJX47_RS02015 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HJX47_RS02020 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HJX47_RS02025 ENOG4105W53 bacterioferritin-associated ferredoxin HJX47_RS02030 ENOG4108UQY Iron-storage protein HJX47_RS02045 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HJX47_RS02050 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HJX47_RS02060 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HJX47_RS02065 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HJX47_RS02070 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HJX47_RS02075 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HJX47_RS02080 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HJX47_RS02085 ENOG41083MP 50s ribosomal protein l29 HJX47_RS02090 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HJX47_RS02095 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HJX47_RS02100 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HJX47_RS02115 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HJX47_RS02120 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HJX47_RS02130 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HJX47_RS02135 ENOG4105VPB 50S ribosomal protein L30 HJX47_RS02140 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HJX47_RS02145 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HJX47_RS02150 ENOG41067V7 50S ribosomal protein L36 HJX47_RS02155 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HJX47_RS02160 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HJX47_RS02165 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HJX47_RS02170 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJX47_RS02175 ENOG4108ZT0 50S ribosomal protein l17 HJX47_RS02180 ENOG4105VTS DnaJ-like, subfamily C HJX47_RS02185 ENOG4105W1Y Transcriptional regulator HJX47_RS02190 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HJX47_RS02195 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HJX47_RS02200 ENOG4105C1A potassium transporter peripheral membrane HJX47_RS02205 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HJX47_RS02210 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HJX47_RS02215 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HJX47_RS02220 ENOG4105C79 DNA protecting protein DprA HJX47_RS02230 ENOG4108WI1 Dna topoisomerase HJX47_RS02235 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HJX47_RS02240 ENOG4105E2X shikimate dehydrogenase HJX47_RS02245 ENOG4105SG3 Protein of unknown function (DUF1488) HJX47_RS02250 ENOG4108Z0R Transferase HJX47_RS02280 ENOG4105XCM membrane LIPOPROTEIN HJX47_RS02285 ENOG4105BZS acriflavin resistance protein HJX47_RS02290 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJX47_RS02295 ENOG4108XG4 DNA-binding transcriptional regulator HJX47_RS02305 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HJX47_RS02310 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HJX47_RS02315 ENOG4108IA2 Sodium pantothenate symporter HJX47_RS02320 ENOG4105RG0 Membrane HJX47_RS02325 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HJX47_RS02330 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HJX47_RS02340 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HJX47_RS02355 ENOG41062P1 Diguanylate cyclase phosphodiesterase HJX47_RS02365 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HJX47_RS02370 ENOG4105VQ7 Rod shape-determining protein MreD HJX47_RS02375 ENOG4108Z03 MAF-like protein HJX47_RS02380 ENOG4105C03 ribonuclease HJX47_RS02385 ENOG4105QD6 exported protein HJX47_RS02390 ENOG4105D1U peptidase U62 modulator of DNA gyrase HJX47_RS02395 ENOG4105CR8 Transcriptional regulator HJX47_RS02410 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HJX47_RS02415 ENOG4105UNR (Barnase) inhibitor HJX47_RS02420 ENOG4105RID UPF0379 protein yhcN HJX47_RS02425 ENOG4105RID UPF0379 protein yhcN HJX47_RS02430 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HJX47_RS02435 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HJX47_RS02450 ENOG4105C8P )-transporter HJX47_RS02455 ENOG4106DSS Tartrate dehydratase subunit alpha HJX47_RS02460 ENOG4107GFK fumarate HJX47_RS02470 ENOG4107QSA Oxaloacetate decarboxylase HJX47_RS02475 ENOG4105D9Q decarboxylase (Beta subunit) HJX47_RS02485 ENOG4105C0H protease HJX47_RS02490 ENOG4105C0H protease HJX47_RS02495 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HJX47_RS02500 ENOG4105D6Z AFG1 family ATPase HJX47_RS02505 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HJX47_RS02520 ENOG4107MKT Stringent starvation protein a HJX47_RS02525 ENOG4105KB2 stringent starvation protein b HJX47_RS02530 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HJX47_RS02535 ENOG4105BZ8 glutamate synthase HJX47_RS02540 ENOG4105CBC glutamate synthase HJX47_RS02545 ENOG4105N5T Radical SAM Protein HJX47_RS02550 ENOG4108I5G Major Facilitator superfamily HJX47_RS02555 ENOG4105CPQ Dehydrogenase HJX47_RS02565 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HJX47_RS02570 ENOG4105BZU Histidine kinase HJX47_RS02575 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HJX47_RS02585 ENOG41080Z8 PHOSPHOCARRIER protein HJX47_RS02590 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HJX47_RS02595 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HJX47_RS02600 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HJX47_RS02605 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJX47_RS02610 ENOG4108IUZ ABC transporter HJX47_RS02615 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HJX47_RS02620 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HJX47_RS02625 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HJX47_RS02630 ENOG4105C2X Arabinose 5-phosphate isomerase HJX47_RS02635 ENOG4105FEU K -dependent Na -Ca exchanger HJX47_RS02640 ENOG4105DHJ ABC, transporter HJX47_RS02645 ENOG4105CY3 ABC transporter, permease HJX47_RS02650 ENOG4107PE3 Mammalian cell entry related domain protein HJX47_RS02655 ENOG4105E3I toluene tolerance HJX47_RS02660 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HJX47_RS02665 ENOG4105VFK BolA family HJX47_RS02670 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HJX47_RS02675 ENOG4105HVQ Regulatory factor of maltose metabolism HJX47_RS02680 ENOG4105EAH synthase HJX47_RS02685 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HJX47_RS02690 ENOG4105K46 50S ribosomal protein l27 HJX47_RS02695 ENOG4105QYV Membrane HJX47_RS02700 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HJX47_RS02705 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HJX47_RS02710 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HJX47_RS02715 ENOG4105HBR Rna-binding protein HJX47_RS02720 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HJX47_RS02725 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HJX47_RS02730 ENOG4105EEI dihydropteroate synthase HJX47_RS02735 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HJX47_RS02740 ENOG4105NTZ Preprotein translocase subunit SecG HJX47_RS02755 ENOG4108UII YfaZ family HJX47_RS02760 ENOG4108PNB DNA-binding transcriptional regulator HJX47_RS02765 ENOG4105CDH Citrulline--aspartate ligase HJX47_RS02780 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HJX47_RS02785 ENOG4105CHV Transcription elongation factor NusA HJX47_RS02790 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HJX47_RS02795 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HJX47_RS02800 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HJX47_RS02805 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HJX47_RS02810 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HJX47_RS02825 ENOG4105C1J atp-dependent rna helicase HJX47_RS02830 ENOG4105CIC tryptophan-specific transport protein HJX47_RS02835 ENOG4105DEN Luciferase family HJX47_RS02855 ENOG4108YYD acetyltransferase HJX47_RS02860 ENOG41082IR Excinuclease ABC C subunit domain protein HJX47_RS02865 ENOG4108ZPB UPF0306 protein HJX47_RS02870 ENOG4107R7Y intracellular protease Pfpi family HJX47_RS02875 ENOG4105K4T epimerase HJX47_RS02880 ENOG4107S21 permease HJX47_RS02885 ENOG4105W4M Transport-associated protein HJX47_RS02890 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HJX47_RS02895 ENOG41082RQ UPF0102 protein HJX47_RS02900 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HJX47_RS02905 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HJX47_RS02910 ENOG4105CTX dehydratase HJX47_RS02920 ENOG4105DJB Major Facilitator Superfamily HJX47_RS02925 ENOG4105CNV Aldolase HJX47_RS02930 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HJX47_RS02935 ENOG4105BZW Glycerate kinase HJX47_RS02960 ENOG4106D80 Uncharacterized protein YhaL HJX47_RS02965 ENOG4108CNN domain protein HJX47_RS02970 ENOG4105CWB LysR family transcriptional Regulator HJX47_RS02975 ENOG4105KAF membrAne HJX47_RS02980 ENOG4105CHF Glutathione S-transferase HJX47_RS02985 ENOG4108VBZ doxx family HJX47_RS02990 ENOG4105YJD HJX47_RS02995 ENOG41090KG Inner membrane protein YqjE HJX47_RS03000 ENOG4105NE1 Conserved Protein HJX47_RS03005 ENOG4105WAY exported protein HJX47_RS03010 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HJX47_RS03015 ENOG4106W5V Membrane HJX47_RS03020 ENOG4107YCY Transcriptional regulator HJX47_RS03025 ENOG4105DPW Major facilitator superfamily MFS_1 HJX47_RS03035 ENOG4105CTX dehydratase HJX47_RS03040 ENOG4105P66 Membrane HJX47_RS03045 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HJX47_RS03050 ENOG4105DU1 integral membrane protein, terc HJX47_RS03055 ENOG4105EE0 oxidoreductase HJX47_RS03060 ENOG4108VKG metal-dependent hydrolase HJX47_RS03075 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HJX47_RS03080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJX47_RS03085 ENOG4107RYS Autoinducer-2 (AI-2) kinase HJX47_RS03090 ENOG4105DKT Transcriptional regulator HJX47_RS03095 ENOG4105C2J ABC transporter HJX47_RS03100 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HJX47_RS03105 ENOG4105F5R ABC transporter HJX47_RS03110 ENOG4105D4B ABC, transporter HJX47_RS03115 ENOG41061GT Aldolase HJX47_RS03120 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HJX47_RS03125 ENOG4105C8Y Acetylornithine aminotransferase HJX47_RS03130 ENOG4105NTW Transcriptional regulator HJX47_RS03140 ENOG4105Q26 Siderophore-interacting protein HJX47_RS03155 ENOG4108UTZ Dihydroxyacetone kinase HJX47_RS03160 ENOG4105CMT Dihydroxyacetone kinase HJX47_RS03190 ENOG4105C0A alcohol dehydrogenase HJX47_RS03205 ENOG4105YCI dehydratase medium subunit HJX47_RS03210 ENOG4108ZFT Dehydratase small subunit HJX47_RS03215 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HJX47_RS03220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJX47_RS03225 ENOG4105XXV Acid-resistance protein HJX47_RS03230 ENOG4108YK4 Acid-resistance membrane protein HJX47_RS03235 ENOG4108V08 YfdX protein HJX47_RS03240 ENOG4105BZU Histidine kinase HJX47_RS03245 ENOG4108WQH regulatoR HJX47_RS03265 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJX47_RS03300 ENOG4105KSC Transcriptional regulator, TraR DksA family HJX47_RS03305 ENOG4105VZ1 Replication Protein HJX47_RS03340 ENOG4105ED4 portal protein HJX47_RS03485 ENOG4105ZTC transcriptional activator, Ogr delta HJX47_RS03495 ENOG4108VCA G U mismatch-specific DNA glycosylase HJX47_RS03500 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJX47_RS03505 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HJX47_RS03515 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HJX47_RS03525 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HJX47_RS03535 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HJX47_RS03540 ENOG4105CQM Urea amidohydrolase subunit alpha HJX47_RS03545 ENOG4105KI2 Urea amidohydrolase subunit beta HJX47_RS03550 ENOG4108YZ9 Urea amidohydrolase subunit gamma HJX47_RS03555 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HJX47_RS03570 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HJX47_RS03575 ENOG4107ZVW dihydroneopterin aldolase HJX47_RS03580 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HJX47_RS03585 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HJX47_RS03590 ENOG4106MWK domain protein HJX47_RS03595 ENOG4105I7R Adenylate cyclase HJX47_RS03600 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HJX47_RS03605 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HJX47_RS03620 ENOG4105W0Z cytoplasmic protein HJX47_RS03635 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HJX47_RS03640 ENOG4106032 Glutathionylspermidine synthase HJX47_RS03645 ENOG4105F1G UPF0441 protein HJX47_RS03655 ENOG41087AY ADP-Ribose pyrophosphatase HJX47_RS03660 ENOG4108SX3 cytoplasmic protein HJX47_RS03665 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HJX47_RS03670 ENOG4105IPS esterase HJX47_RS03675 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJX47_RS03680 ENOG4105VRH Antibiotic biosynthesis monooxygenase HJX47_RS03685 ENOG4105NF4 modulator of drug activity HJX47_RS03690 ENOG4105DHQ Histidine kinase HJX47_RS03695 ENOG4105XJC Two component transcriptional regulator (Winged helix family HJX47_RS03700 ENOG4105H4F exported protein HJX47_RS03705 ENOG4105F4I Transcriptional regulator HJX47_RS03710 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJX47_RS03715 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HJX47_RS03720 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HJX47_RS03725 ENOG4105CCT upf0313 protein HJX47_RS03735 ENOG4105CV8 reductase HJX47_RS03740 ENOG4108I6A alcohol dehydrogenase HJX47_RS03745 ENOG4105CF7 AraC family transcriptional regulator HJX47_RS03750 ENOG4108K81 inner membrane protein YghB HJX47_RS03755 ENOG4105C28 cystathionine HJX47_RS03760 ENOG4105CWK Biopolymer transport protein, ExbB HJX47_RS03765 ENOG4108ZZF transport protein (ExbD) HJX47_RS03770 ENOG4105CT4 transporter HJX47_RS03775 ENOG4105E4I Glycoside hydrolase family 28 HJX47_RS03780 ENOG4108TEB UPF0114 protein HJX47_RS03790 ENOG410900S Protein of unknown function (DUF2623) HJX47_RS03795 ENOG4105CYM Glutathione S-transferase HJX47_RS03810 ENOG4106032 Glutathionylspermidine synthase HJX47_RS03815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJX47_RS03835 ENOG4105CC0 LysR family Transcriptional regulator HJX47_RS03840 ENOG4105C28 cystathionine HJX47_RS03855 ENOG4108UQV Membrane HJX47_RS03860 ENOG4105CXN decarboxylase HJX47_RS03865 ENOG4105EAA nucleoside HJX47_RS03870 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HJX47_RS03875 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HJX47_RS03880 ENOG4105CEN a g-specific adenine glycosylase HJX47_RS03885 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HJX47_RS03890 ENOG41090ED Protein with unknown function (DUF469) HJX47_RS03895 ENOG4105K33 Periplasmic Protein HJX47_RS03900 ENOG4105CSA Coproporphyrinogen iii oxidase HJX47_RS03905 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HJX47_RS03910 ENOG4105VZ9 UPF0235 protein HJX47_RS03915 ENOG4108VIA integral membrane protein HJX47_RS03920 ENOG4105DFA alanine racemase domain protein HJX47_RS03925 ENOG4105CZX twitching motility protein HJX47_RS03935 ENOG41086KC Transcriptional regulator HJX47_RS03940 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HJX47_RS03945 ENOG4108UJU UPF0301 protein HJX47_RS03950 ENOG4105D7Z glutathione synthase HJX47_RS03955 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HJX47_RS03960 ENOG4105RWS endonuclease I HJX47_RS03965 ENOG4105GPY SprT protein HJX47_RS03970 ENOG4107QNK )-transporter HJX47_RS03975 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HJX47_RS03995 ENOG4105CYW agmatinase HJX47_RS04020 ENOG4105CHR reductase HJX47_RS04025 ENOG4108FUF Transcriptional regulator, IclR family HJX47_RS04055 ENOG4105CHR reductase HJX47_RS04060 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HJX47_RS04075 ENOG4105J5J Outer membrane porin HJX47_RS04080 ENOG4108K0D peptidase, M48 HJX47_RS04085 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJX47_RS04090 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJX47_RS04100 ENOG4105D2N Aldolase HJX47_RS04105 ENOG4105D64 Mechanosensitive ion channel HJX47_RS04110 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HJX47_RS04115 ENOG4105MPN Membrane HJX47_RS04120 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HJX47_RS04125 ENOG4105E66 phosphoriboisomerase A HJX47_RS04135 ENOG4108JQ1 Dehydrogenase HJX47_RS04140 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HJX47_RS04150 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HJX47_RS04155 ENOG4105E07 UPF0149 protein HJX47_RS04160 ENOG4107RAQ aminopeptidase HJX47_RS04165 ENOG4105D0A hydroxylase HJX47_RS04170 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HJX47_RS04175 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HJX47_RS04180 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HJX47_RS04185 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HJX47_RS04190 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HJX47_RS04200 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HJX47_RS04220 ENOG4105CS2 ec 3.2.1.21 HJX47_RS04225 ENOG4108Q3X Transcriptional regulator HJX47_RS04230 ENOG4105N5Z UPF0267 protein HJX47_RS04235 ENOG4108UT2 hemolysin iii HJX47_RS04245 ENOG4105Y75 tpr repeat protein HJX47_RS04250 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HJX47_RS04255 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HJX47_RS04260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJX47_RS04265 ENOG4105T95 Thiol disulfide interChange protein HJX47_RS04270 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HJX47_RS04280 ENOG4105CRK lysyL-tRNA synthetase HJX47_RS04285 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HJX47_RS04295 ENOG4108K5P (LipO)protein HJX47_RS04385 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJX47_RS04400 ENOG4105CPC Aldo Keto reductase HJX47_RS04415 ENOG4105W7K Transcriptional regulator HJX47_RS04440 ENOG4107R5R arsenical pump membrane protein HJX47_RS04445 ENOG4105K89 arsenate reductase HJX47_RS04450 ENOG4105DUX Transporter HJX47_RS04455 ENOG4105V2F Uncharacterized protein yoac HJX47_RS04460 ENOG4105ETP RND efflux system, outer membrane lipoprotein HJX47_RS04465 ENOG4108MI0 Resistance protein HJX47_RS04470 ENOG4105J12 Multidrug resistance protein mdtN HJX47_RS04480 ENOG4105VR1 Pfam:DUF1271 HJX47_RS04485 ENOG410830R acetyltransferase HJX47_RS04495 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HJX47_RS04500 ENOG4108T65 Fimbrial HJX47_RS04505 ENOG4108SQA Fimbrial HJX47_RS04510 ENOG4105CW0 outer membrane usher protein HJX47_RS04515 ENOG4108NAE Fimbrial chaperone protein HJX47_RS04520 ENOG4108S54 Fimbrial protein HJX47_RS04525 ENOG4108RQP Major type 1 subunit fimbrin HJX47_RS04535 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HJX47_RS04540 ENOG4108W9T type 1 fimbriae regulatory protein HJX47_RS04545 ENOG4105D7X high-affinity nickel-transporter HJX47_RS04550 ENOG4108ZT1 Transcriptional regulator HJX47_RS04555 ENOG4108KTG Membrane protein, drug metabolite transporter HJX47_RS04565 ENOG4108T1W Fimbrial subunit type 3 HJX47_RS04605 ENOG4107S5I aldo keto reductase HJX47_RS04610 ENOG4108MHD transport protein HJX47_RS04620 ENOG4105C5Q Transcriptional regulator HJX47_RS04625 ENOG4105CHU acetyl-coa acetyltransferase HJX47_RS04630 ENOG4108QGT oligogalacturonate-specific porin HJX47_RS04635 ENOG4105CAZ oligogalacturonide lyase HJX47_RS04645 ENOG4105CHR reductase HJX47_RS04650 ENOG4107QNK )-transporter HJX47_RS04655 ENOG4106NDP Transcriptional regulator HJX47_RS04665 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJX47_RS04670 ENOG4108HKT sucrose-6-phosphate hydrolase HJX47_RS04685 ENOG4108IJ9 (ABC) transporter HJX47_RS04690 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HJX47_RS04695 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HJX47_RS04700 ENOG4105YKW HJX47_RS04710 ENOG4105RQF LysR family Transcriptional regulator HJX47_RS04720 ENOG4105DDV Transcriptional regulator (LacI family HJX47_RS04725 ENOG4105CK1 PTS System HJX47_RS04730 ENOG4105CS2 ec 3.2.1.21 HJX47_RS04735 ENOG4107YCY Transcriptional regulator HJX47_RS04745 ENOG41060NJ transcriptional regulator HJX47_RS04750 ENOG4105CEY Amp-dependent synthetase and ligase HJX47_RS04755 ENOG4107S74 Lysophospholipid transporter LplT HJX47_RS04760 ENOG4105CPC Aldo Keto reductase HJX47_RS04765 ENOG4105SUV lipoprotein YgdR HJX47_RS04770 ENOG4105EE5 Membrane protein terC HJX47_RS04775 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HJX47_RS04785 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HJX47_RS04790 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HJX47_RS04795 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HJX47_RS04800 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HJX47_RS04805 ENOG4105IPU prepilin peptidase dependent protein A HJX47_RS04810 ENOG4105JCS prepilin peptidase dependent protein HJX47_RS04815 ENOG4105SEN Protein of unknown function (DUF2509) HJX47_RS04820 ENOG4105RVB Prepilin peptidase dependent protein c HJX47_RS04825 ENOG4105DSY exodeoxyribonuclease V, gamma HJX47_RS04830 ENOG4107QXK peptidase HJX47_RS04835 ENOG4107QKA exodeoxyribonuclease V beta HJX47_RS04840 ENOG4107QYX exodeoxyribonuclease v alpha HJX47_RS04850 ENOG4107QZM n-acetylglutamate synthase HJX47_RS04855 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HJX47_RS04860 ENOG4107QZB decarboxylase HJX47_RS04865 ENOG4105JZC GHMP kinase HJX47_RS04875 ENOG4105KTW ethanolamine utilization protein HJX47_RS04880 ENOG4105M3W utilization protein HJX47_RS04890 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HJX47_RS04895 ENOG4105C0A alcohol dehydrogenase HJX47_RS04900 ENOG4108EKI Dehydrogenase HJX47_RS04910 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HJX47_RS04925 ENOG4105KNY Microcompartments protein HJX47_RS04930 ENOG4105KNY Microcompartments protein HJX47_RS04940 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HJX47_RS04945 ENOG4108ZFT Dehydratase small subunit HJX47_RS04950 ENOG4105YCI dehydratase medium subunit HJX47_RS04955 ENOG4105DMB glycerol dehydratase HJX47_RS04970 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJX47_RS04975 ENOG4107XVH Transcriptional regulator HJX47_RS04980 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HJX47_RS04985 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HJX47_RS04990 ENOG41081F0 Precorrin-8x methylmutase HJX47_RS04995 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HJX47_RS05000 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HJX47_RS05005 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HJX47_RS05010 ENOG4105CIA precorrin-4 C(11)-methyltransferase HJX47_RS05015 ENOG4108P62 biosynthesis protein (CbiG) HJX47_RS05020 ENOG4105E4R Precorrin-3B C17-methyltransferase HJX47_RS05025 ENOG4105QUC reductase HJX47_RS05030 ENOG4107PPM cobalt chelatase HJX47_RS05035 ENOG4105DVK Precorrin-2 c20-methyltransferase HJX47_RS05040 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HJX47_RS05045 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HJX47_RS05050 ENOG4108V4M Cobalt abc transporter HJX47_RS05060 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HJX47_RS05065 ENOG4108YZT Adenosylcobinamide kinase HJX47_RS05090 ENOG4105CA3 membrane-bound lytic murein transglycosylase HJX47_RS05095 ENOG4105CUZ uba thif-type nad fad binding protein HJX47_RS05100 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HJX47_RS05105 ENOG4105C9B Cysteine desulfurase HJX47_RS05110 ENOG4105M5B (LipO)protein HJX47_RS05115 ENOG4105ETT transcriptional Regulator, LysR family HJX47_RS05120 ENOG4105M08 Membrane HJX47_RS05130 ENOG4107EDW L-fucose operon activator HJX47_RS05135 ENOG4105NWF RbsD or FucU transport HJX47_RS05140 ENOG4105CMG Carbohydrate kinase HJX47_RS05150 ENOG4105EDR glucose galactose transporter HJX47_RS05160 ENOG4107W7X Aldolase HJX47_RS05165 ENOG4105C0A alcohol dehydrogenase HJX47_RS05170 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HJX47_RS05175 ENOG4108JU7 Transcriptional regulator HJX47_RS05185 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJX47_RS05200 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS05205 ENOG4108UMI ABC transporter, permease HJX47_RS05210 ENOG4105D01 (LipO)protein HJX47_RS05215 ENOG41079KZ Major Facilitator Superfamily HJX47_RS05225 ENOG4105GVF (ABC) transporter HJX47_RS05230 ENOG4105EJQ L-serine dehydratase HJX47_RS05235 ENOG4105C44 Serine transporter HJX47_RS05240 ENOG4105EWT decarboxylase family HJX47_RS05245 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HJX47_RS05250 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HJX47_RS05255 ENOG4105WP7 tRNA pseudouridine synthase C HJX47_RS05260 ENOG4105DR9 pseudouridine synthase HJX47_RS05265 ENOG4105QDK Flavodoxin HJX47_RS05270 ENOG4105DJB Major Facilitator Superfamily HJX47_RS05275 ENOG4105EQX glucarate dehydratase HJX47_RS05280 ENOG4105EQX glucarate dehydratase HJX47_RS05285 ENOG4105BZW Glycerate kinase HJX47_RS05290 ENOG4105BZU Histidine kinase HJX47_RS05295 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HJX47_RS05300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HJX47_RS05305 ENOG4105DXN mazG family HJX47_RS05310 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HJX47_RS05315 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HJX47_RS05330 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HJX47_RS05335 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HJX47_RS05340 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HJX47_RS05345 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HJX47_RS05350 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HJX47_RS05355 ENOG4105DTT CRISPR-associated helicase, cas3 HJX47_RS05360 ENOG4105CYR Crispr-associated protein, cse1 family HJX47_RS05370 ENOG41060M0 Crispr-associated protein, cse4 family HJX47_RS05375 ENOG4108VWQ crispr-associated protein HJX47_RS05385 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HJX47_RS05390 ENOG4105PWE CRISPR-associated protein cas2 HJX47_RS05405 ENOG4108MXK alkaline phosphatase isozyme conversion HJX47_RS05410 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HJX47_RS05415 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HJX47_RS05425 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HJX47_RS05430 ENOG4105N0Z inner membrane protein ygbE HJX47_RS05435 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HJX47_RS05440 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HJX47_RS05445 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HJX47_RS05450 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HJX47_RS05460 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HJX47_RS05465 ENOG4108K5P (LipO)protein HJX47_RS05470 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJX47_RS05495 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HJX47_RS05500 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJX47_RS05505 ENOG4105KZM cytoplasmic protein HJX47_RS05515 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HJX47_RS05535 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS05540 ENOG4105EHG Permease protein HJX47_RS05545 ENOG4107R4I Periplasmic binding protein HJX47_RS05550 ENOG4106QJH hemin transport protein HJX47_RS05570 ENOG4108N2Y auxin Efflux HJX47_RS05580 ENOG4105VXR cytoplasmic protein HJX47_RS05585 ENOG4105CC5 ABC transporter HJX47_RS05590 ENOG4105CC5 ABC transporter HJX47_RS05595 ENOG4105DIK (ABC) transporter HJX47_RS05600 ENOG4105DSE periplasmic solute binding protein HJX47_RS05605 ENOG4105DDV Transcriptional regulator (LacI family HJX47_RS05610 ENOG4105DKQ ROK family HJX47_RS05615 ENOG4105VCP PTS System HJX47_RS05620 ENOG4105CK1 PTS System HJX47_RS05625 ENOG4105VZJ PTS System HJX47_RS05630 ENOG4105CK1 PTS System HJX47_RS05635 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJX47_RS05645 ENOG4105CS2 ec 3.2.1.21 HJX47_RS05655 ENOG4105C45 hydrogenase expression formation protein (HypE) HJX47_RS05660 ENOG4105CQS hydrogenase expression formation protein HypD HJX47_RS05665 ENOG41083WG hydrogenase assembly chaperone HJX47_RS05670 ENOG4107RSS Hydrogenase accessory protein HypB HJX47_RS05675 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HJX47_RS05680 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HJX47_RS05685 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HJX47_RS05690 ENOG4107R30 NADH dehydrogenase HJX47_RS05695 ENOG4107TDF Formate hydrogenlyase subunit 4 HJX47_RS05700 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJX47_RS05705 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HJX47_RS05710 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HJX47_RS05715 ENOG4105I6X formate hydrogenlyase maturation HJX47_RS05720 ENOG4108MG9 hydrogenase 3 maturation protease HJX47_RS05730 ENOG4105CS2 ec 3.2.1.21 HJX47_RS05735 ENOG4105C5Y PTS System HJX47_RS05745 ENOG4105DDV Transcriptional regulator (LacI family HJX47_RS05750 ENOG4108RC0 Electron transport protein HJX47_RS05755 ENOG4105C8H hydrogenase maturation protein Hypf HJX47_RS05765 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HJX47_RS05770 ENOG4105CNW domain protein HJX47_RS05780 ENOG4108JUA Transcriptional regulator HJX47_RS05790 ENOG410804X Transcriptional regulator HJX47_RS05795 ENOG4105J92 DNA-binding transcriptional activator GutM HJX47_RS05800 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HJX47_RS05805 ENOG4105VI0 Pts system, glucitol sorbitol-specific HJX47_RS05810 ENOG4105DZY Pts system, glucitol sorbitol-specific HJX47_RS05815 ENOG410787A Pts system, glucitol sorbitol-specific HJX47_RS05820 ENOG4105CVE Lytic murein transglycosylase HJX47_RS05830 ENOG4105CC5 ABC transporter HJX47_RS05835 ENOG4105DSE periplasmic solute binding protein HJX47_RS05840 ENOG4107TH8 cina domain protein HJX47_RS05845 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HJX47_RS05850 ENOG4105Y3E Modulates RecA activity (By similarity) HJX47_RS05855 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HJX47_RS05860 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HJX47_RS05895 ENOG4105K3G Periplasmic Protein HJX47_RS05900 ENOG4107VXZ Hydrolase HJX47_RS05905 ENOG4105W39 Membrane HJX47_RS05910 ENOG4105D9M gamma-glutamylcysteine synthetase HJX47_RS05925 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HJX47_RS05930 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJX47_RS05935 ENOG4105CW7 secretion protein, HlyD family HJX47_RS05945 ENOG4105NTK Transcriptional repressor Mpra HJX47_RS05955 ENOG4105ZED uncharacterized protein ygaH HJX47_RS05960 ENOG4108UMN azlc family HJX47_RS05965 ENOG4105GIJ Glycine betaine HJX47_RS05970 ENOG4108HQS Glycine betaine HJX47_RS05975 ENOG4108IJ7 Glycine betaine HJX47_RS05980 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJX47_RS05985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJX47_RS05990 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HJX47_RS05995 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HJX47_RS06000 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HJX47_RS06005 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJX47_RS06010 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HJX47_RS06015 ENOG4108WMJ Protein of unknown function (DUF2002) HJX47_RS06020 ENOG4108RNS Exports L-alanine (By similarity) HJX47_RS06030 ENOG4108X73 DNA- binding protein HJX47_RS06045 ENOG4108V62 Rhodanese domain protein HJX47_RS06050 ENOG41080HT Transcriptional regulator, arsr family HJX47_RS06060 ENOG4105CC0 LysR family Transcriptional regulator HJX47_RS06065 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HJX47_RS06070 ENOG4105C26 Dehydrogenase HJX47_RS06075 ENOG4105X0I Fimbrial HJX47_RS06080 ENOG4108VCD Chaperone HJX47_RS06085 ENOG4105CW0 outer membrane usher protein HJX47_RS06095 ENOG4108VCD Chaperone HJX47_RS06115 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HJX47_RS06120 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HJX47_RS06125 ENOG4105MP9 class II Aldolase HJX47_RS06130 ENOG4105CDA abc transporter atp-binding protein HJX47_RS06135 ENOG4106TNF Periplasmic binding protein HJX47_RS06150 ENOG4105CYW agmatinase HJX47_RS06155 ENOG4105EVZ LysR family transcriptional regulator HJX47_RS06170 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJX47_RS06175 ENOG4105UEI Transcriptional Regulator AraC Family HJX47_RS06200 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HJX47_RS06205 ENOG4108Z1B Cyclase dehydrase HJX47_RS06215 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJX47_RS06225 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HJX47_RS06230 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HJX47_RS06235 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HJX47_RS06240 ENOG4108JU6 CBS domain protein HJX47_RS06245 ENOG4106KVJ cytochrome C assembly protein HJX47_RS06250 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HJX47_RS06255 ENOG4105K5M 30s ribosomal protein S16 HJX47_RS06260 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HJX47_RS06265 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HJX47_RS06270 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HJX47_RS06290 ENOG41090EK ompa motb domain protein HJX47_RS06295 ENOG4108KHX Diguanylate cyclase HJX47_RS06300 ENOG4108WS1 HJX47_RS06305 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJX47_RS06310 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HJX47_RS06320 ENOG4105CQC Prephenate dehydratase HJX47_RS06330 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HJX47_RS06335 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJX47_RS06340 ENOG4105C34 Pseudouridine synthase HJX47_RS06345 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HJX47_RS06350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJX47_RS06375 ENOG4105CSH Transporter HJX47_RS06380 ENOG4105T42 (LipO)protein HJX47_RS06385 ENOG4105JIM Phosphatidylserine synthase HJX47_RS06390 ENOG4105CD5 CoA-binding domain protein HJX47_RS06395 ENOG4106IUH DTW domain containing protein HJX47_RS06400 ENOG4105K63 Thioredoxin HJX47_RS06405 ENOG4105EIB trna rrna methyltransferase HJX47_RS06410 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HJX47_RS06415 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HJX47_RS06420 ENOG4105C1J atp-dependent rna helicase HJX47_RS06425 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HJX47_RS06430 ENOG4108IYU L-aspartate oxidase HJX47_RS06445 ENOG41069PW sigma-e factor negative regulatory protein HJX47_RS06450 ENOG4105VQK sigma E regulatory protein, MucB RseB HJX47_RS06455 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HJX47_RS06460 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HJX47_RS06465 ENOG4105C3F Signal peptidase i HJX47_RS06470 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HJX47_RS06475 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HJX47_RS06480 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HJX47_RS06485 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HJX47_RS06490 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HJX47_RS06495 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HJX47_RS06500 ENOG4106G6Q Transcriptional regulator HJX47_RS06505 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HJX47_RS06510 ENOG4108Z6B deaminase HJX47_RS06515 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HJX47_RS06520 ENOG4108ETH Formylglycinamide ribotide synthetase HJX47_RS06525 ENOG4107WP9 Histidine kinase HJX47_RS06530 ENOG4108SKK alpha helix protein HJX47_RS06535 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJX47_RS06540 ENOG4108YZA Nitrogen regulatory protein pii HJX47_RS06545 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJX47_RS06550 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HJX47_RS06555 ENOG4108SB3 DoxX Family HJX47_RS06560 ENOG4108NZE NAGC-like transcriptional regulator HJX47_RS06565 ENOG4107HQ7 repeat protein HJX47_RS06570 ENOG4107QNK )-transporter HJX47_RS06575 ENOG4108ZKT aldose 1-epimerase HJX47_RS06580 ENOG4105D8G Major Facilitator superfamily HJX47_RS06585 ENOG4108MN2 Stationary phase inducible protein CsiE HJX47_RS06590 ENOG41065CD Exported protein HJX47_RS06595 ENOG4105D7X high-affinity nickel-transporter HJX47_RS06605 ENOG4105ECY inositol monophosphatase HJX47_RS06610 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HJX47_RS06615 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HJX47_RS06620 ENOG4105C3J Cysteine desulfurase HJX47_RS06625 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HJX47_RS06630 ENOG4108Z4V iron-sulfur cluster assembly HJX47_RS06635 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HJX47_RS06640 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HJX47_RS06645 ENOG4108ZIT Ferredoxin, 2FE-2S HJX47_RS06650 ENOG4105WVQ Fe-S assembly protein IscX HJX47_RS06655 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HJX47_RS06660 ENOG4105YYA enhanced serine sensitivity protein SseB HJX47_RS06670 ENOG4105KHC sulfurtransferase HJX47_RS06675 ENOG4105DN3 alpha-2-macroglobulin domain protein HJX47_RS06680 ENOG4108JQB penicillin-binding protein 1C HJX47_RS06685 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HJX47_RS06690 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HJX47_RS06695 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HJX47_RS06700 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HJX47_RS06710 ENOG4105N21 Membrane HJX47_RS06715 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJX47_RS06720 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HJX47_RS06730 ENOG4105VPD cellular component movement HJX47_RS06735 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HJX47_RS06740 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HJX47_RS06745 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HJX47_RS06755 ENOG4105C4X radical SAM domain protein HJX47_RS06770 ENOG41062G3 Protein of unknown function (DUF2633) HJX47_RS06775 ENOG4105BZU Histidine kinase HJX47_RS06780 ENOG4105C9X ppx gppa phosphatase HJX47_RS06785 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HJX47_RS06790 ENOG4108V3E phosphoribosylglycinamide formyltransferase HJX47_RS06795 ENOG4105CXB phosphoribosylaminoimidazole synthetase HJX47_RS06800 ENOG41066F8 ROK family HJX47_RS06805 ENOG4105CS2 ec 3.2.1.21 HJX47_RS06810 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HJX47_RS06815 ENOG4105C2W permease HJX47_RS06820 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HJX47_RS06830 ENOG4105K89 arsenate reductase HJX47_RS06835 ENOG4105ERG peptidase m48, ste24p HJX47_RS06845 ENOG4105C02 permease HJX47_RS06850 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HJX47_RS06855 ENOG4105RH4 Glycine cleavage system transcriptional repressor HJX47_RS06860 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HJX47_RS06865 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJX47_RS06870 ENOG4105C8V SAICAR synthetase HJX47_RS06875 ENOG4105CGZ zinc metallopeptidase HJX47_RS06880 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HJX47_RS06885 ENOG4106KED esterase YpfH HJX47_RS06890 ENOG4105XYK UPF0370 protein HJX47_RS06895 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HJX47_RS06900 ENOG4105KUZ arsenate reductase HJX47_RS06910 ENOG4105BZS acriflavin resistance protein HJX47_RS06915 ENOG4105BZ8 glutamate synthase HJX47_RS06920 ENOG4107VIJ nudix hydrolase HJX47_RS06925 ENOG4108PVD exported protein HJX47_RS06930 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJX47_RS06935 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJX47_RS06940 ENOG4105C6K Malic enzyme HJX47_RS06945 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HJX47_RS06950 ENOG4106S4J ethanolamine utilization protein EutP HJX47_RS06955 ENOG4105NDK ethanolamine utilization protein HJX47_RS06960 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HJX47_RS06965 ENOG4108IJ2 phosphate acetyltransferase HJX47_RS06970 ENOG4105KNY Microcompartments protein HJX47_RS06975 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HJX47_RS06980 ENOG4108EKI Dehydrogenase HJX47_RS06985 ENOG4107YMV ethanolamine utilization protein HJX47_RS06990 ENOG4105C0A alcohol dehydrogenase HJX47_RS06995 ENOG4105ENY Ethanolamine utilization protein eutH HJX47_RS07000 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HJX47_RS07005 ENOG4105CPD ethanolamine ammonia-lyase HJX47_RS07015 ENOG4106D67 ethanolamine utilization protein HJX47_RS07020 ENOG4108X49 Ethanolamine utilization protein EutK HJX47_RS07025 ENOG4108K3Z AraC family transcriptional regulator HJX47_RS07030 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HJX47_RS07035 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HJX47_RS07040 ENOG4108R6G acetyltransferase HJX47_RS07045 ENOG4105QZU Inner membrane protein YfeZ HJX47_RS07050 ENOG4105E7K (LipO)protein HJX47_RS07055 ENOG4105EZR dyp-type peroxidase family protein HJX47_RS07065 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HJX47_RS07070 ENOG4108I5D sulfate abc transporter HJX47_RS07075 ENOG4105ECW sulfate abc transporter HJX47_RS07080 ENOG4108IJ6 ABC transporter HJX47_RS07085 ENOG4105C6T cysteine synthase HJX47_RS07090 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HJX47_RS07095 ENOG4105CSW GntR family transcriptional regulator HJX47_RS07100 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HJX47_RS07110 ENOG4105C5Y PTS System HJX47_RS07115 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HJX47_RS07120 ENOG4105KZ7 phosphocarrier protein hpr HJX47_RS07130 ENOG4105C6T cysteine synthase HJX47_RS07135 ENOG4105EXN Sulfate transport protein CysZ HJX47_RS07140 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HJX47_RS07145 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HJX47_RS07150 ENOG4105VRT cytoplasmic protein HJX47_RS07155 ENOG4105DHU Bile acid HJX47_RS07160 ENOG4108M0I Transcriptional regulator HJX47_RS07185 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HJX47_RS07190 ENOG4105GXM Putative transcription regulator (DUF1323) HJX47_RS07195 ENOG4105HZG regulatoR HJX47_RS07215 ENOG4108KMM Diguanylate cyclase HJX47_RS07220 ENOG4105D9N nucleoside HJX47_RS07225 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HJX47_RS07230 ENOG4109076 Conserved Protein HJX47_RS07235 ENOG4105CPC Aldo Keto reductase HJX47_RS07240 ENOG4107RA9 decarboxylase HJX47_RS07250 ENOG4105CHC glucokinase (EC 2.7.1.2) HJX47_RS07255 ENOG4105DY9 regulatoR HJX47_RS07260 ENOG4108HRK Histidine kinase HJX47_RS07275 ENOG4105CHM Aminotransferase HJX47_RS07285 ENOG4105DJ2 Major Facilitator Superfamily HJX47_RS07290 ENOG4107Y2X deaminase HJX47_RS07295 ENOG4105DND Transcriptional regulator HJX47_RS07340 ENOG4105E5W Transporter HJX47_RS07345 ENOG4105EMU Dehydrogenase HJX47_RS07350 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HJX47_RS07395 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HJX47_RS07405 ENOG4108JJB ABC transporter HJX47_RS07425 ENOG4105KF5 hemolysin expression-modulating protein HJX47_RS07435 ENOG4105CHR reductase HJX47_RS07440 ENOG4105DAS pts system HJX47_RS07445 ENOG4105DAS pts system HJX47_RS07450 ENOG4105ETZ PTS System HJX47_RS07455 ENOG4105F3R pts system mannose fructose sorbose family iid HJX47_RS07470 ENOG4105CMT Dihydroxyacetone kinase HJX47_RS07475 ENOG4108VA3 3-hexulose-6-phosphate synthase HJX47_RS07480 ENOG41080HJ 6-phospho 3-hexuloisomerase HJX47_RS07510 ENOG4108FZ9 Chaperone HJX47_RS07535 ENOG4105DHT Metal Dependent Phosphohydrolase HJX47_RS07555 ENOG4105S64 Formate nitrite transporter HJX47_RS07560 ENOG410903C (LipO)protein HJX47_RS07565 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HJX47_RS07570 ENOG4105KZW UPF0381 protein HJX47_RS07575 ENOG4105CHU acetyl-coa acetyltransferase HJX47_RS07580 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HJX47_RS07585 ENOG4108BY2 phosphohistidine phosphatase HJX47_RS07590 ENOG4108DG9 Smr protein MutS2 HJX47_RS07595 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HJX47_RS07600 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HJX47_RS07605 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HJX47_RS07610 ENOG4105EJ9 Membrane HJX47_RS07615 ENOG4108BPE -transporting atpase HJX47_RS07620 ENOG4105MH2 YfcL protein HJX47_RS07625 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HJX47_RS07630 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJX47_RS07635 ENOG4105F9N Major Facilitator Superfamily HJX47_RS07640 ENOG4106WZ1 flagella biosynthesis regulator HJX47_RS07650 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJX47_RS07655 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HJX47_RS07660 ENOG4105DQR SNARE associated Golgi HJX47_RS07665 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HJX47_RS07670 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HJX47_RS07675 ENOG4108S3P Sporulation domain protein HJX47_RS07680 ENOG4105E96 Colicin v production protein HJX47_RS07685 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HJX47_RS07690 ENOG4108JUB Transcriptional regulator HJX47_RS07700 ENOG4105E5D amino acid HJX47_RS07705 ENOG4106M28 alanine racemase domain protein HJX47_RS07715 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HJX47_RS07725 ENOG4105E89 ABC transporter HJX47_RS07730 ENOG4105E89 ABC transporter HJX47_RS07735 ENOG4105DSP amino acid AbC transporter HJX47_RS07740 ENOG4106YG3 ABC transporter HJX47_RS07745 ENOG4108JEH abc transporter atp-binding protein HJX47_RS07750 ENOG4105KNA -acetyltransferase HJX47_RS07760 ENOG4105ECP epimerase HJX47_RS07765 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HJX47_RS07770 ENOG4105CYM Glutathione S-transferase HJX47_RS07775 ENOG4108SHQ Glutathione S-transferase HJX47_RS07780 ENOG4108RE9 Phosphodiesterase HJX47_RS07785 ENOG4105PTV Nudix Hydrolase HJX47_RS07790 ENOG4105C6K Malic enzyme HJX47_RS07795 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HJX47_RS07800 ENOG4105PQ6 UPF0208 membrane protein HJX47_RS07810 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HJX47_RS07815 ENOG4107QWE )-transporter HJX47_RS07820 ENOG4105DK2 UPF0207 protein HJX47_RS07825 ENOG4105CHM Aminotransferase HJX47_RS07830 ENOG4107NQ8 LysR family Transcriptional regulator HJX47_RS07840 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HJX47_RS07845 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJX47_RS07850 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJX47_RS07855 ENOG4105GKE subunit e HJX47_RS07860 ENOG4107QIZ NADH dehydrogenase HJX47_RS07865 ENOG4108IEH NADH dehydrogenase subunit g HJX47_RS07870 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HJX47_RS07880 ENOG4107UFS subunit j HJX47_RS07885 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJX47_RS07890 ENOG4105D65 subunit l HJX47_RS07895 ENOG4105C8S subunit m HJX47_RS07900 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJX47_RS07905 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HJX47_RS07910 ENOG4107YB6 acetyltransferase, (GNAT) family HJX47_RS07915 ENOG4105E4F Isochorismate synthase HJX47_RS07920 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HJX47_RS07925 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HJX47_RS07930 ENOG4108IPT Naphthoate synthase HJX47_RS07935 ENOG4105DNI Converts SHCHC to OSB (By similarity) HJX47_RS07940 ENOG4105CEY Amp-dependent synthetase and ligase HJX47_RS07950 ENOG4105DNE Transposase HJX47_RS07960 ENOG4108UII YfaZ family HJX47_RS07965 ENOG4108EWA cinA-like protein HJX47_RS07970 ENOG4107258 Transcriptional regulator HJX47_RS07975 ENOG4105CXK mandelate racemase muconate lactonizing HJX47_RS07980 ENOG4105CSP Major Facilitator Superfamily HJX47_RS07985 ENOG4105CNV Aldolase HJX47_RS07990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HJX47_RS07995 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HJX47_RS08000 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HJX47_RS08005 ENOG4105CXY transporter HJX47_RS08010 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HJX47_RS08015 ENOG4105XPH Ferredoxin HJX47_RS08020 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJX47_RS08025 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJX47_RS08030 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HJX47_RS08035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJX47_RS08040 ENOG4105BZU Histidine kinase HJX47_RS08045 ENOG41068CG regulatoR HJX47_RS08050 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HJX47_RS08065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJX47_RS08070 ENOG4105CF1 Alkylated DNA repair protein HJX47_RS08075 ENOG4105IBP Cyclic peptide transporter HJX47_RS08080 ENOG4105CJW magnesium transporter HJX47_RS08085 ENOG4105CHH sulfate transporter HJX47_RS08100 ENOG4105F4G Membrane HJX47_RS08110 ENOG4105E68 Sulfatase HJX47_RS08115 ENOG4105PAN UPF0352 protein HJX47_RS08120 ENOG4106V8H Nucleoid-associated protein HJX47_RS08125 ENOG4105N2W Transcriptional regulator HJX47_RS08130 ENOG4107VIJ nudix hydrolase HJX47_RS08145 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HJX47_RS08150 ENOG4105CFI type iii restriction protein res subunit HJX47_RS08155 ENOG4105I08 Pseudouridine synthase HJX47_RS08160 ENOG4105C2C drug resistance transporter, Bcr CflA HJX47_RS08165 ENOG4105HG6 HJX47_RS08170 ENOG4108JQ5 ABC transporter HJX47_RS08175 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HJX47_RS08180 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HJX47_RS08185 ENOG4105E43 Extracellular solute-binding protein, family 5 HJX47_RS08190 ENOG4105CXC rtn protein HJX47_RS08195 ENOG4107TT5 NLP P60 protein HJX47_RS08200 ENOG41076MN Phosphoesterase, PA-phosphatase related HJX47_RS08205 ENOG4105CKI cobalamin synthesis protein HJX47_RS08210 ENOG4105DEI Mannitol dehydrogenase HJX47_RS08215 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HJX47_RS08225 ENOG4105KRS Proteinase inhibitor HJX47_RS08240 ENOG4105S8Q sugar efflux transporter HJX47_RS08245 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HJX47_RS08250 ENOG4105DE4 1-phosphofructokinase HJX47_RS08255 ENOG4105DM4 PTS System HJX47_RS08260 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HJX47_RS08265 ENOG4105HMI Membrane HJX47_RS08270 ENOG4105DUM transcriptional regulator, lysR family HJX47_RS08275 ENOG4108IQI permease HJX47_RS08280 ENOG4105D05 Receptor HJX47_RS08290 ENOG4105EUJ GTP cyclohydrolase i HJX47_RS08295 ENOG4105DHF Membrane HJX47_RS08300 ENOG41060NJ transcriptional regulator HJX47_RS08310 ENOG4105C2J ABC transporter HJX47_RS08315 ENOG4107SDZ Galactoside transport system permease protein mglC HJX47_RS08320 ENOG4107GZ4 SanA protein HJX47_RS08325 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HJX47_RS08330 ENOG41067MG lrgb family HJX47_RS08335 ENOG4105VAW lrga family HJX47_RS08340 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HJX47_RS08345 ENOG4105TW1 Carbohydrate-selective porin OprB HJX47_RS08360 ENOG4105CS2 ec 3.2.1.21 HJX47_RS08370 ENOG4105KHU inner membrane protein YohD HJX47_RS08375 ENOG41069YE inner membrane protein yohC HJX47_RS08380 ENOG41061WM D-Alanyl-D-Alanine HJX47_RS08390 ENOG4105CXG d-lactate dehydrogenase HJX47_RS08395 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HJX47_RS08400 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HJX47_RS08405 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HJX47_RS08410 ENOG4108IJ8 ABC transporter HJX47_RS08415 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HJX47_RS08425 ENOG4108HRK Histidine kinase HJX47_RS08430 ENOG4108NEV two component transcriptional regulator, LytTR family HJX47_RS08435 ENOG4108W15 Protein of unknown function (DUF1456) HJX47_RS08440 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HJX47_RS08445 ENOG4105D1F ATP-binding protein HJX47_RS08455 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HJX47_RS08460 ENOG4105EJC lysr family transcriptional regulator HJX47_RS08465 ENOG4105C7N Xanthine uracil vitamin C permease HJX47_RS08470 ENOG4105CPN adenine deaminase HJX47_RS08475 ENOG4105DUM transcriptional regulator, lysR family HJX47_RS08490 ENOG4105DWF phosphomethylpyrimidine kinase HJX47_RS08495 ENOG4105EIE fructose-bisphosphate aldolase HJX47_RS08500 ENOG4105IE8 Alpha-ketoglutarate permease HJX47_RS08525 ENOG4105DEI Mannitol dehydrogenase HJX47_RS08530 ENOG4105CMG Carbohydrate kinase HJX47_RS08535 ENOG4105IE8 Alpha-ketoglutarate permease HJX47_RS08540 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HJX47_RS08550 ENOG4105CFP Peptidase U32 HJX47_RS08555 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJX47_RS08560 ENOG4105EB3 Histidine kinase HJX47_RS08565 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJX47_RS08570 ENOG4105BZS acriflavin resistance protein HJX47_RS08575 ENOG4105BZS acriflavin resistance protein HJX47_RS08580 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJX47_RS08585 ENOG4105CK2 sodium dicarboxylate symporter HJX47_RS08605 ENOG4105BZU Histidine kinase HJX47_RS08610 ENOG4105R8A Heat shock protein HJX47_RS08615 ENOG4105D03 DNA-3-methyladenine glycosylase II HJX47_RS08620 ENOG4105DBI uridine monophosphokinase HJX47_RS08625 ENOG4105DHP deoxycytidine triphosphate deaminase HJX47_RS08630 ENOG4108GAE asmA family HJX47_RS08635 ENOG4105EE5 Membrane protein terC HJX47_RS08640 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HJX47_RS08645 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HJX47_RS08655 ENOG4108MRJ HJX47_RS08660 ENOG4105DAY polysaccharide export protein HJX47_RS08675 ENOG4105D3Q Sugar transferase HJX47_RS08685 ENOG4107S6X Glycosyl transferase, family 2 HJX47_RS08690 ENOG4105CG5 Glycosyl transferase (Group 1 HJX47_RS08715 ENOG4105K64 Glycosyl transferase, family 2 HJX47_RS08725 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HJX47_RS08765 ENOG4105EY8 ABC transporter HJX47_RS08790 ENOG4105E5H Transposase HJX47_RS08795 ENOG4108YXQ IS66 Orf2 family protein HJX47_RS08805 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HJX47_RS08810 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HJX47_RS08815 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HJX47_RS08820 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HJX47_RS08825 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HJX47_RS08830 ENOG4105CIH Imidazole acetol-phosphate transaminase HJX47_RS08840 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HJX47_RS08850 ENOG4107SRH Nad-dependent epimerase dehydratase HJX47_RS08855 ENOG4105EQ1 Transcriptional regulator HJX47_RS08865 ENOG4105CUB amino acid HJX47_RS08870 ENOG4105YVS arsR family transcriptional regulator HJX47_RS08875 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HJX47_RS08880 ENOG4105CJB Exodeoxyribonuclease I HJX47_RS08885 ENOG4105DZ1 carboxypeptidase HJX47_RS08890 ENOG4105EKQ RNA-directed DNA polymerase HJX47_RS08900 ENOG4105DR8 Membrane HJX47_RS08905 ENOG41090HJ UPF0265 protein HJX47_RS08910 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HJX47_RS08915 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HJX47_RS08920 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HJX47_RS08930 ENOG41090U3 tautomerase HJX47_RS08935 ENOG4105HEI LysR family (Transcriptional regulator HJX47_RS08940 ENOG4108KMH lipoate-protein ligase a HJX47_RS08945 ENOG4105CSH Transporter HJX47_RS08955 ENOG4105BZU Histidine kinase HJX47_RS08965 ENOG4108YS1 cytoplasmic protein HJX47_RS08970 ENOG4105YP6 Domain of unknown function (DUF1869) HJX47_RS08975 ENOG4105ETT transcriptional Regulator, LysR family HJX47_RS08990 ENOG4105BZU Histidine kinase HJX47_RS09015 ENOG4105UQX Mate efflux family protein HJX47_RS09025 ENOG4105FYV Amp nucleosidase HJX47_RS09045 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HJX47_RS09050 ENOG4108WUH Transcriptional regulator, TetR family HJX47_RS09055 ENOG4105EEQ Na H antiporter HJX47_RS09070 ENOG4107R11 Transcriptional regulator HJX47_RS09075 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJX47_RS09095 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HJX47_RS09105 ENOG4105FCK Membrane HJX47_RS09115 ENOG4105Y0K Inner membrane protein YedR HJX47_RS09120 ENOG4105EST Metal Dependent Phosphohydrolase HJX47_RS09125 ENOG4105DVF Cytosine-specific methyltransferase HJX47_RS09130 ENOG41090BB DNA mismatch endonuclease (vsr) HJX47_RS09135 ENOG4105FDR Membrane HJX47_RS09140 ENOG4105CKW Inner membrane protein yedI HJX47_RS09150 ENOG4105YX3 cellular response to acidity HJX47_RS09165 ENOG4105JCU Inherit from NOG: (Lipo)protein HJX47_RS09170 ENOG4105E5K Alpha-amylase HJX47_RS09175 ENOG4105EAB amino acid AbC transporter HJX47_RS09180 ENOG4105K6H D-cysteine desulfhydrase HJX47_RS09185 ENOG4105E5Q amino acid AbC transporter HJX47_RS09190 ENOG4105CDA abc transporter atp-binding protein HJX47_RS09195 ENOG4105VJY transcriptional regulator HJX47_RS09200 ENOG4105XVG cytoplasmic protein HJX47_RS09205 ENOG4105WH1 Two component transcriptional regulator luxr family HJX47_RS09240 ENOG4106RHG Yeca family HJX47_RS09245 ENOG4105E0U tyrosine-specific transport protein HJX47_RS09250 ENOG4105VVZ metal-binding protein HJX47_RS09255 ENOG41090A1 ferritin HJX47_RS09270 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJX47_RS09275 ENOG4105N4N Protein of unknown function (DUF2766) HJX47_RS09290 ENOG4108UEC Ferritin-like protein HJX47_RS09300 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HJX47_RS09310 ENOG4105CNN ABC, transporter HJX47_RS09320 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HJX47_RS09325 ENOG4108VA4 Universal stress protein HJX47_RS09330 ENOG4105CT4 transporter HJX47_RS09335 ENOG4105F5H Glycosyl Hydrolase Family 88 HJX47_RS09340 ENOG4105C75 arginyL-tRNA synthetase HJX47_RS09345 ENOG4106ZCM YecM protein HJX47_RS09350 ENOG4106N3A copper homeostasis protein cutc HJX47_RS09355 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HJX47_RS09360 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HJX47_RS09365 ENOG4105WJG Glutathione HJX47_RS09370 ENOG41081XQ Conserved Protein HJX47_RS09375 ENOG4105D3W isochorismatase HJX47_RS09380 ENOG4105C9M aspartyl-trna synthetase HJX47_RS09385 ENOG4108TIT dATP pyrophosphohydrolase HJX47_RS09390 ENOG4105CDY transcriptional regulatory protein HJX47_RS09395 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HJX47_RS09400 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HJX47_RS09405 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HJX47_RS09410 ENOG4105FAV ABC, transporter HJX47_RS09420 ENOG4105NXV High-affinity zinc uptake system protein HJX47_RS09425 ENOG4105DR5 peptidase HJX47_RS09430 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HJX47_RS09435 ENOG4105CA9 Pyruvate kinase HJX47_RS09440 ENOG4106KNT transcriptional regulator HJX47_RS09450 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HJX47_RS09455 ENOG4105C01 Dihydroxy-acid dehydratase HJX47_RS09460 ENOG4108UHU Aldolase HJX47_RS09470 ENOG4105X2V dna damage-inducible protein HJX47_RS09475 ENOG4108Q2J Inner membrane protein YebE HJX47_RS09480 ENOG4105CUG Oligopeptidase b HJX47_RS09485 ENOG4105UMD exodeoxyribonuclease X HJX47_RS09490 ENOG4105MPK DNA polymerase III subunit theta HJX47_RS09495 ENOG4105FXM Copper resistance protein HJX47_RS09500 ENOG4108PNC copper resistance HJX47_RS09505 ENOG4105NKT exported protein HJX47_RS09515 ENOG4108MJ5 VirK protein HJX47_RS09520 ENOG4108R1E Serine threonine protein phosphatase 1 HJX47_RS09525 ENOG4105UVW uncharacterized protein yebW HJX47_RS09530 ENOG4105WT8 Protein of unknown function (DUF1480) HJX47_RS09535 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HJX47_RS09540 ENOG4105DY2 Paraquat-inducible protein b HJX47_RS09545 ENOG4105H2K paraquat-inducible protein a HJX47_RS09550 ENOG4108ZGC gaf domain protein HJX47_RS09555 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HJX47_RS09560 ENOG4105CN1 protease HJX47_RS09565 ENOG4105D0M Protease HtpX homolog HJX47_RS09570 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJX47_RS09575 ENOG4105J4Q Transcriptional regulator HJX47_RS09580 ENOG4105TIK HJX47_RS09590 ENOG4105Q3Y exported protein HJX47_RS09610 ENOG4105CJN penicillin-binding protein HJX47_RS09615 ENOG4105DHI Methyltransferase HJX47_RS09620 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HJX47_RS09625 ENOG4108NK4 UPF0266 membrane protein HJX47_RS09630 ENOG4105F3R pts system mannose fructose sorbose family iid HJX47_RS09635 ENOG4105ETZ PTS System HJX47_RS09640 ENOG4105DAS pts system HJX47_RS09645 ENOG4105EE5 Membrane protein terC HJX47_RS09650 ENOG4107XTP (EAL) domain protein HJX47_RS09660 ENOG4105EJQ L-serine dehydratase HJX47_RS09665 ENOG4105P8F nudix hydrolase HJX47_RS09675 ENOG4105X5C UPF0181 protein HJX47_RS09680 ENOG4105M4H endoribonuclease L-psp HJX47_RS09685 ENOG4105DVT helicase HJX47_RS09690 ENOG41072GX Peptidase M22 Glycoprotease HJX47_RS09695 ENOG4105Y4Z Outer Membrane Lipoprotein HJX47_RS09700 ENOG4105CEY Amp-dependent synthetase and ligase HJX47_RS09705 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HJX47_RS09710 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HJX47_RS09715 ENOG4107QMS site-determining protein HJX47_RS09720 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HJX47_RS09725 ENOG4105VNG YcgL domain-containing protein HJX47_RS09730 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HJX47_RS09735 ENOG4108ZZ3 UPF0260 protein HJX47_RS09745 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HJX47_RS09750 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HJX47_RS09755 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HJX47_RS09760 ENOG4105ED1 spovr family HJX47_RS09770 ENOG4105MWK D-amino acid dehydrogenase, small subunit HJX47_RS09780 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HJX47_RS09785 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HJX47_RS09790 ENOG4106JQ5 Transglycosylase SLT domain HJX47_RS09795 ENOG4105E0K tonB-dependent siderophore receptor HJX47_RS09850 ENOG410811B TRANSCRIPTIONal HJX47_RS09855 ENOG4105C7B Threonine dehydratase HJX47_RS09860 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HJX47_RS09870 ENOG4105C6N Formate acetyltransferase HJX47_RS09885 ENOG4105C32 Amino acid ABC transporter (Permease) HJX47_RS09890 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJX47_RS09895 ENOG4105C0Z ABC transporter HJX47_RS09900 ENOG4108IV0 ABC, transporter HJX47_RS09905 ENOG4107YNJ LysR family Transcriptional regulator HJX47_RS09925 ENOG4105CSH Transporter HJX47_RS09935 ENOG4105F04 LysR family Transcriptional regulator HJX47_RS09945 ENOG4105D3G Pseudouridine synthase HJX47_RS09950 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HJX47_RS09975 ENOG4108ZG0 Ompa motb domain protein HJX47_RS09985 ENOG4105CS6 Rhs element vgr protein HJX47_RS10060 ENOG4105E6M Sulphatase-modifying factor protein HJX47_RS10160 ENOG4105C3G gtp-binding protein HJX47_RS10165 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HJX47_RS10170 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HJX47_RS10180 ENOG4105CHH sulfate transporter HJX47_RS10185 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HJX47_RS10190 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HJX47_RS10200 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HJX47_RS10205 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HJX47_RS10210 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HJX47_RS10215 ENOG4108YY7 Invasion gene expression up-regulator SirB HJX47_RS10220 ENOG41063JG Transcriptional regulator HJX47_RS10225 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HJX47_RS10230 ENOG4105EWV Sodium calcium exchanger membrane region HJX47_RS10235 ENOG4105WS7 Cation transport regulator HJX47_RS10240 ENOG4108NH8 Cation transport protein HJX47_RS10250 ENOG41090EX DsrE family HJX47_RS10265 ENOG4105I5W Transporter HJX47_RS10275 ENOG4105D7T ABC transporter HJX47_RS10280 ENOG4107QZF nitrite reductase NADPH large subunit HJX47_RS10290 ENOG4105ID0 Putative invasin HJX47_RS10295 ENOG4105WH1 Two component transcriptional regulator luxr family HJX47_RS10300 ENOG4105BZU Histidine kinase HJX47_RS10305 ENOG4105DQQ Major facilitator superfamily MFS_1 HJX47_RS10315 ENOG4105CRU nitrate reductase, alpha subunit HJX47_RS10320 ENOG4108IUE nitrate reductase beta subunit HJX47_RS10325 ENOG4105R3A Nitrate reductase HJX47_RS10330 ENOG41076YT nitrate reductase, gamma subunit HJX47_RS10365 ENOG4105CIY formyltetrahydrofolate deformylase HJX47_RS10375 ENOG4105D78 K07001 NTE family protein HJX47_RS10380 ENOG4105I93 response regulator HJX47_RS10385 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HJX47_RS10400 ENOG4107104 thymidine kinase HJX47_RS10405 ENOG4105C0A alcohol dehydrogenase HJX47_RS10415 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HJX47_RS10425 ENOG4108J59 Extracellular solute-binding protein, family 5 HJX47_RS10430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJX47_RS10435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJX47_RS10440 ENOG4105C3U ABC transporter HJX47_RS10445 ENOG4108JQ7 (ABC) transporter HJX47_RS10450 ENOG4105EYW Ion transport protein HJX47_RS10455 ENOG4108W5H UPF0263 protein HJX47_RS10460 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HJX47_RS10475 ENOG4108YYC ycei family HJX47_RS10485 ENOG4105K9H YciI-like protein HJX47_RS10490 ENOG410822N TonB family HJX47_RS10500 ENOG4105P10 Uncharacterized protein ydiZ HJX47_RS10505 ENOG4105DE4 1-phosphofructokinase HJX47_RS10510 ENOG4108NE3 Salt-induced outer membrane protein HJX47_RS10605 ENOG4105CDU Replicative dna helicase HJX47_RS10650 ENOG4105MPK DNA polymerase III subunit theta HJX47_RS10665 ENOG4105RWQ Protein of unknown function (DUF1364) HJX47_RS10700 ENOG4105KUS lysozyme HJX47_RS10705 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HJX47_RS10855 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HJX47_RS10860 ENOG41082NX 50s ribosomal protein l35 HJX47_RS10875 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HJX47_RS10880 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HJX47_RS10885 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HJX47_RS10895 ENOG4105MWK D-amino acid dehydrogenase, small subunit HJX47_RS10900 ENOG4105RQF LysR family Transcriptional regulator HJX47_RS10910 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HJX47_RS10915 ENOG4105D01 (LipO)protein HJX47_RS10920 ENOG4108V06 Glutathione peroxidase HJX47_RS10930 ENOG4108QBX (LipO)protein HJX47_RS10935 ENOG4105CNG UPF0061 protein HJX47_RS10945 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJX47_RS10960 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HJX47_RS10970 ENOG4105IPI Membrane HJX47_RS10975 ENOG4105CQB FAD linked oxidase domain protein HJX47_RS10980 ENOG4105KA0 thioesterase Superfamily protein HJX47_RS10985 ENOG4105Y3U Transglycosylase-associated protein HJX47_RS11000 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HJX47_RS11010 ENOG4105E0A ABC, transporter HJX47_RS11015 ENOG4105EHG Permease protein HJX47_RS11025 ENOG4106KR7 LysR family Transcriptional regulator HJX47_RS11050 ENOG4105DMF Dehydrogenase HJX47_RS11055 ENOG4105KBX Transcriptional regulator, TetR family HJX47_RS11075 ENOG4108Z4V iron-sulfur cluster assembly HJX47_RS11080 ENOG4105DIW FeS assembly protein SUFB HJX47_RS11085 ENOG4105C3K feS assembly ATPase SufC HJX47_RS11090 ENOG4105JRK feS assembly protein SufD HJX47_RS11095 ENOG4105C9B Cysteine desulfurase HJX47_RS11100 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HJX47_RS11105 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJX47_RS11115 ENOG4105CA9 Pyruvate kinase HJX47_RS11130 ENOG4105RFR Protein of unknown function (DUF2767) HJX47_RS11145 ENOG4105DJB Major Facilitator Superfamily HJX47_RS11150 ENOG4105E2X shikimate dehydrogenase HJX47_RS11155 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HJX47_RS11160 ENOG4108W0P ABC transporter HJX47_RS11165 ENOG4105EHG Permease protein HJX47_RS11170 ENOG4105S10 periplasmic binding protein HJX47_RS11175 ENOG4108K2P TRANSCRIPTIONal HJX47_RS11180 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HJX47_RS11185 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) HJX47_RS11190 ENOG4107UB2 Alpha beta hydrolase fold HJX47_RS11195 ENOG4105IKQ hydratase HJX47_RS11200 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HJX47_RS11205 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HJX47_RS11210 ENOG4108SC4 )-transporter HJX47_RS11225 ENOG4108T2C cysteine dioxygenase type I HJX47_RS11230 ENOG4106KR7 LysR family Transcriptional regulator HJX47_RS11235 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJX47_RS11255 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HJX47_RS11260 ENOG4108IY8 ABC, transporter HJX47_RS11270 ENOG4105E0A ABC, transporter HJX47_RS11275 ENOG4105DQ5 transport system permease protein HJX47_RS11295 ENOG4106PMH Extracellular solute-binding protein family 3 HJX47_RS11300 ENOG4105E5Q amino acid AbC transporter HJX47_RS11305 ENOG4105CDA abc transporter atp-binding protein HJX47_RS11320 ENOG41083G8 Multidrug resistance protein MdtM HJX47_RS11345 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HJX47_RS11350 ENOG4105DG4 malate L-lactate dehydrogenase HJX47_RS11360 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HJX47_RS11365 ENOG4107Z33 ABC transporter, permease HJX47_RS11395 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HJX47_RS11400 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HJX47_RS11405 ENOG41060IM Heme exporter protein HJX47_RS11415 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HJX47_RS11420 ENOG4105DA4 cytochrome c-type biogenesis protein HJX47_RS11425 ENOG4107QX9 Thiol disulfide interChange protein HJX47_RS11430 ENOG4105KWW Biogenesis protein HJX47_RS11455 ENOG410822N TonB family HJX47_RS11470 ENOG41062D9 Histidine kinase HJX47_RS11475 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJX47_RS11490 ENOG4105BZS acriflavin resistance protein HJX47_RS11500 ENOG4105CHR reductase HJX47_RS11505 ENOG4105C7K acetolactate synthase HJX47_RS11520 ENOG4105DTD Dehydrogenase HJX47_RS11525 ENOG4105CY2 Citrate transporter HJX47_RS11530 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HJX47_RS11535 ENOG4105CHU acetyl-coa acetyltransferase HJX47_RS11550 ENOG4106NZI LysR family Transcriptional regulator HJX47_RS11580 ENOG4105DXI Major Facilitator superfamily HJX47_RS11595 ENOG4105CQB FAD linked oxidase domain protein HJX47_RS11600 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HJX47_RS11620 ENOG4105KME endoribonuclease L-psp HJX47_RS11625 ENOG4107TTD cytosine deaminase HJX47_RS11635 ENOG4105EMY transcriptional regulator HJX47_RS11695 ENOG4108JQ7 (ABC) transporter HJX47_RS11700 ENOG4105C3U ABC transporter HJX47_RS11725 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HJX47_RS11730 ENOG4105E98 transcriptional regulator DeoR family HJX47_RS11740 ENOG4107B2H carbonic anhydrase HJX47_RS11770 ENOG4105CY0 Metallo-Beta-Lactamase HJX47_RS11815 ENOG4108URH decarboxylase HJX47_RS11825 ENOG4107QI1 Mate efflux family protein HJX47_RS11830 ENOG4108R6K riboflavin synthase, subunit alpha HJX47_RS11835 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HJX47_RS11840 ENOG4105CZQ inner membrane transport protein YdhC HJX47_RS11845 ENOG4105F52 Transcriptional regulator HJX47_RS11850 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS11860 ENOG4105F27 Major Facilitator HJX47_RS11865 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJX47_RS11875 ENOG4105K4H Nlp p60 protein HJX47_RS11880 ENOG4105M2J Glutaredoxin HJX47_RS11885 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HJX47_RS11890 ENOG4108UYE Lactoylglutathione lyase HJX47_RS11895 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJX47_RS11900 ENOG4108WUH Transcriptional regulator, TetR family HJX47_RS11905 ENOG4105XZD Fe-S protein HJX47_RS11910 ENOG4107RGM aldo keto reductase HJX47_RS11915 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJX47_RS11920 ENOG4105DSW Fusaric acid resistance protein HJX47_RS11925 ENOG4105Y49 secretion protein, HlyD family HJX47_RS11940 ENOG4105BZU Histidine kinase HJX47_RS11945 ENOG4108XTF Outer Membrane Lipoprotein HJX47_RS11950 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HJX47_RS11955 ENOG410642K Lysozyme inhibitor HJX47_RS11960 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HJX47_RS11965 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HJX47_RS11970 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HJX47_RS11975 ENOG4108K3A Glutathione S-transferase HJX47_RS11985 ENOG4105CSM endonuclease III HJX47_RS11995 ENOG4108UQQ Electron transport complex HJX47_RS12020 ENOG4105M9B inner membrane protein ydgK HJX47_RS12030 ENOG4105CS2 ec 3.2.1.21 HJX47_RS12040 ENOG4105D9R oxidoreductase HJX47_RS12045 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HJX47_RS12050 ENOG4105EQ0 Major Facilitator superfamily HJX47_RS12070 ENOG4105CPW cytochrome b561 HJX47_RS12090 ENOG4105DDW LysR family Transcriptional regulator HJX47_RS12095 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HJX47_RS12100 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HJX47_RS12105 ENOG4105E32 cytoplasmic protein HJX47_RS12110 ENOG4105EBR Carboxylesterase HJX47_RS12125 ENOG4108Z9I -acetyltransferase HJX47_RS12130 ENOG4107WE3 acetyltransferase YdcK HJX47_RS12135 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HJX47_RS12140 ENOG41088CC tellurite resistance protein tehB HJX47_RS12145 ENOG4108KKZ (LipO)protein HJX47_RS12150 ENOG4108RNG Permease of the drug metabolite transporter HJX47_RS12155 ENOG4105UEI Transcriptional Regulator AraC Family HJX47_RS12160 ENOG4105DKK Benzoate HJX47_RS12165 ENOG4108JCI Transcriptional regulator HJX47_RS12175 ENOG4105CFP Peptidase U32 HJX47_RS12195 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJX47_RS12200 ENOG4105C4M (Ubiquinol oxidase) subunit I HJX47_RS12205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJX47_RS12210 ENOG4107TYH extracellular solute-binding protein family 1 HJX47_RS12215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS12220 ENOG4105D81 ABC transporter, permease HJX47_RS12225 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HJX47_RS12230 ENOG4105C26 Dehydrogenase HJX47_RS12255 ENOG410654E Membrane HJX47_RS12260 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HJX47_RS12275 ENOG4105DEF Extracellular solute-binding protein, family 5 HJX47_RS12280 ENOG4105R71 cytoplasmic protein HJX47_RS12285 ENOG4108T9Y Inner membrane protein ydcZ HJX47_RS12290 ENOG4108Z7F N-acetyltransferase HJX47_RS12300 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HJX47_RS12305 ENOG4105DU0 nucleoside hydrolase HJX47_RS12315 ENOG41065TG regulatoR HJX47_RS12320 ENOG4105CI2 imidazolone-5-propionate hydrolase HJX47_RS12325 ENOG4105CHB tonB-dependent Receptor HJX47_RS12330 ENOG4108NS2 receptor HJX47_RS12340 ENOG4105C85 amino acid HJX47_RS12345 ENOG4105EQ2 LysR family Transcriptional regulator HJX47_RS12355 ENOG4105DEN Luciferase family HJX47_RS12370 ENOG4105EAB amino acid AbC transporter HJX47_RS12380 ENOG4105DRP amino acid AbC transporter HJX47_RS12385 ENOG4105CDA abc transporter atp-binding protein HJX47_RS12395 ENOG4108N27 Glutathione S-transferase HJX47_RS12415 ENOG4105CT4 transporter HJX47_RS12430 ENOG4108MEJ flavin reductase domain protein HJX47_RS12435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS12440 ENOG4105C4Y ABC transporter HJX47_RS12445 ENOG4107RCV ABC transporter, permease HJX47_RS12450 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HJX47_RS12455 ENOG4105D0D Nitrate reductase 2, gamma subunit HJX47_RS12460 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HJX47_RS12465 ENOG4108IUE nitrate reductase beta subunit HJX47_RS12470 ENOG4105CRU nitrate reductase, alpha subunit HJX47_RS12475 ENOG4107QND Nitrite extrusion protein HJX47_RS12490 ENOG4107HP6 Transcriptional regulator HJX47_RS12495 ENOG4105DTQ mandelate racemase muconate lactonizing HJX47_RS12500 ENOG4105NN7 muconolactone delta-isomerase HJX47_RS12505 ENOG410626B catechol 1,2-dioxygenase HJX47_RS12540 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HJX47_RS12545 ENOG4108MG3 formate dehydrogenase HJX47_RS12560 ENOG4105CSR polyphosphate kinase 2 HJX47_RS12570 ENOG4105F27 Major Facilitator HJX47_RS12585 ENOG4108JQ6 ABC transporter HJX47_RS12590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJX47_RS12605 ENOG4105DQ4 alcohol dehydrogenase HJX47_RS12620 ENOG4105C5H ABC transporter HJX47_RS12635 ENOG4107R1I NAD-dependent malic enzyme HJX47_RS12655 ENOG4105JQN Transcriptional regulator HJX47_RS12660 ENOG4105N0E Protein of unknown function (DUF2543) HJX47_RS12665 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HJX47_RS12680 ENOG4108N8X transition metal ion binding HJX47_RS12690 ENOG4105CG3 alpha amylase, catalytic region HJX47_RS12710 ENOG4108YDI single-species biofilm formation on inanimate substrate HJX47_RS12720 ENOG4108Z9K Osmotically inducible protein HJX47_RS12745 ENOG4105FFC UPF0187 protein HJX47_RS12750 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HJX47_RS12755 ENOG4105C5Q Transcriptional regulator HJX47_RS12760 ENOG4105VCP PTS System HJX47_RS12765 ENOG4108KUU Inner membrane metabolite transport protein ydjE HJX47_RS12770 ENOG4105KT7 mgtC SapB transporter HJX47_RS12775 ENOG4105D6Z AFG1 family ATPase HJX47_RS12780 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HJX47_RS12785 ENOG4106KR7 LysR family Transcriptional regulator HJX47_RS12805 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HJX47_RS12810 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HJX47_RS12815 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HJX47_RS12825 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HJX47_RS12830 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HJX47_RS12840 ENOG4108IGT Dipeptidase HJX47_RS12845 ENOG4108J2P Alpha beta hydrolase fold HJX47_RS12855 ENOG4105E0F Histidine kinase HJX47_RS12870 ENOG4105DY8 decarboxylase HJX47_RS12875 ENOG4108JPW Aminotransferase HJX47_RS12880 ENOG4107Z6I Thiamine biosynthesis protein HJX47_RS12885 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HJX47_RS12890 ENOG4108YI8 ABC transporter HJX47_RS12895 ENOG4105ETU transcriptional activator (TenA HJX47_RS12910 ENOG4105CIB oxidoreductase Domain protein HJX47_RS12920 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS12925 ENOG4105BZU Histidine kinase HJX47_RS12930 ENOG4107QUY Guanine deaminase HJX47_RS12935 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HJX47_RS12975 ENOG4105CVJ phosphoglycerate mutase HJX47_RS12980 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HJX47_RS12990 ENOG41089BK Glutamine amido-transferase HJX47_RS12995 ENOG4105R1U AraC Family Transcriptional Regulator HJX47_RS13020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJX47_RS13045 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJX47_RS13070 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HJX47_RS13090 ENOG4105E5Q amino acid AbC transporter HJX47_RS13100 ENOG4105C5R Aminotransferase HJX47_RS13115 ENOG4105CBN LysR family transcriptional regulator HJX47_RS13125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJX47_RS13130 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HJX47_RS13135 ENOG4105CSH Transporter HJX47_RS13180 ENOG4105FCD Major Facilitator HJX47_RS13190 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS13195 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HJX47_RS13205 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HJX47_RS13210 ENOG4105UP7 3-epimerase HJX47_RS13220 ENOG4108YRF PTS System HJX47_RS13225 ENOG4105DM4 PTS System HJX47_RS13230 ENOG410829K Lysine exporter protein (Lyse ygga) HJX47_RS13235 ENOG4109066 lysm domain bon superfamily protein HJX47_RS13240 ENOG4105CXY transporter HJX47_RS13245 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HJX47_RS13255 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HJX47_RS13260 ENOG4105RHY Pfam:UPF0157 HJX47_RS13265 ENOG4105EQ2 LysR family Transcriptional regulator HJX47_RS13270 ENOG4105CPC Aldo Keto reductase HJX47_RS13275 ENOG4107SET aldo keto reductase HJX47_RS13280 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis HJX47_RS13285 ENOG4105CPC Aldo Keto reductase HJX47_RS13320 ENOG4105ENX hydrolase HJX47_RS13335 ENOG4105MVE transcriptional regulator HJX47_RS13340 ENOG4105CMG Carbohydrate kinase HJX47_RS13345 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HJX47_RS13350 ENOG4105E98 transcriptional regulator DeoR family HJX47_RS13355 ENOG4105UP7 3-epimerase HJX47_RS13360 ENOG4108RVA ribokinase HJX47_RS13365 ENOG4105EDR glucose galactose transporter HJX47_RS13380 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HJX47_RS13385 ENOG4105CHR reductase HJX47_RS13390 ENOG4105CHU acetyl-coa acetyltransferase HJX47_RS13410 ENOG4105BZW Glycerate kinase HJX47_RS13415 ENOG4107VHA regulatoR HJX47_RS13425 ENOG4105JQN Transcriptional regulator HJX47_RS13435 ENOG4107YCY Transcriptional regulator HJX47_RS13440 ENOG4105CI1 PTS System HJX47_RS13445 ENOG4105F8D glycoside hydrolase family 4 HJX47_RS13455 ENOG4105C54 Major Facilitator superfamily HJX47_RS13460 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HJX47_RS13480 ENOG4105NIV Esterase HJX47_RS13485 ENOG4105BZU Histidine kinase HJX47_RS13500 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HJX47_RS13515 ENOG4108VCD Chaperone HJX47_RS13520 ENOG4105CW0 outer membrane usher protein HJX47_RS13530 ENOG4105F32 YngK protein HJX47_RS13535 ENOG4105CAF HipA N-terminal domain protein HJX47_RS13540 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HJX47_RS13545 ENOG4105VT2 5-hydroxyisourate hydrolase HJX47_RS13550 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HJX47_RS13555 ENOG4105C2W permease HJX47_RS13560 ENOG41061H0 Monooxygenase HJX47_RS13565 ENOG4108KSA LysR family transcriptional regulator HJX47_RS13585 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HJX47_RS13600 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HJX47_RS13610 ENOG4105D01 (LipO)protein HJX47_RS13620 ENOG4108UMI ABC transporter, permease HJX47_RS13625 ENOG4105EA8 2-Nitropropane dioxygenase HJX47_RS13635 ENOG4105EGI Transcriptional regulator HJX47_RS13640 ENOG4105CBP Major Facilitator HJX47_RS13650 ENOG4105F9N Major Facilitator Superfamily HJX47_RS13695 ENOG4107QZW Altronate oxidoreductase HJX47_RS13705 ENOG4105BZU Histidine kinase HJX47_RS13710 ENOG4105M0C cytoplasmic protein HJX47_RS13715 ENOG4105CSV Glutaminase HJX47_RS13720 ENOG4105C26 Dehydrogenase HJX47_RS13725 ENOG4105EGI Transcriptional regulator HJX47_RS13735 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HJX47_RS13740 ENOG4105MVE transcriptional regulator HJX47_RS13745 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HJX47_RS13750 ENOG4107S2N Type III effector Hrp-dependent HJX47_RS13755 ENOG4105C0A alcohol dehydrogenase HJX47_RS13760 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HJX47_RS13765 ENOG4108JQ1 Dehydrogenase HJX47_RS13775 ENOG4105JAB phenazine biosynthesis protein, phzf family HJX47_RS13780 ENOG4105F27 Major Facilitator HJX47_RS13790 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HJX47_RS13795 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HJX47_RS13800 ENOG4106DNR multiple antibiotic resistance protein HJX47_RS13810 ENOG4105E5W Transporter HJX47_RS13820 ENOG4108IV0 ABC, transporter HJX47_RS13825 ENOG4105C0Z ABC transporter HJX47_RS13830 ENOG4105CNN ABC, transporter HJX47_RS13835 ENOG4105C32 Amino acid ABC transporter (Permease) HJX47_RS13855 ENOG4105ECQ AraC Family Transcriptional Regulator HJX47_RS13875 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS13880 ENOG4105CNT hydrolase family 2 HJX47_RS13885 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJX47_RS13890 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HJX47_RS13900 ENOG4108J4B Beta-lactamase HJX47_RS13905 ENOG4105MVE transcriptional regulator HJX47_RS13915 ENOG4105G63 Type III effector Hrp-dependent HJX47_RS13920 ENOG4105FB2 class II Aldolase HJX47_RS13925 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HJX47_RS13930 ENOG4105C6Z Gluconate HJX47_RS13950 ENOG4105BZU Histidine kinase HJX47_RS13955 ENOG4108WTK competence damage-inducible protein HJX47_RS13960 ENOG4108ZNX Heat shock protein HJX47_RS13975 ENOG4108WQH regulatoR HJX47_RS13990 ENOG4108RAV Conserved protein HJX47_RS13995 ENOG4105R1U AraC Family Transcriptional Regulator HJX47_RS14005 ENOG4105DGW oligopeptidase A HJX47_RS14010 ENOG4105EMU Dehydrogenase HJX47_RS14015 ENOG4107XBN GntR Family Transcriptional Regulator HJX47_RS14020 ENOG4108U51 Universal stress protein HJX47_RS14025 ENOG4105DEI Mannitol dehydrogenase HJX47_RS14030 ENOG4108I5G Major Facilitator superfamily HJX47_RS14035 ENOG4105KK4 UPF0060 membrane protein HJX47_RS14040 ENOG4105M5Q UPF0482 protein HJX47_RS14045 ENOG4108MK9 spermidine N(1)-acetyltransferase HJX47_RS14055 ENOG4105KBG Protein of unknown function (DUF1161) HJX47_RS14060 ENOG4107QY8 reductase HJX47_RS14065 ENOG4105QAX Iron-sulfur HJX47_RS14070 ENOG4107KGK dmso reductase anchor subunit HJX47_RS14075 ENOG4108NEM leader-binding protein dmsD HJX47_RS14080 ENOG4105CMQ Chloride channel HJX47_RS14085 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HJX47_RS14090 ENOG4105DAG ROK family HJX47_RS14095 ENOG4106NZI LysR family Transcriptional regulator HJX47_RS14100 ENOG4105D94 Major Facilitator Superfamily HJX47_RS14105 ENOG4105CTD carboxy-peptidase HJX47_RS14125 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HJX47_RS14135 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HJX47_RS14140 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HJX47_RS14145 ENOG4105DSF transport protein HJX47_RS14175 ENOG4107TT2 Auxin Efflux Carrier HJX47_RS14180 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HJX47_RS14185 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HJX47_RS14190 ENOG4108K70 Transcriptional regulator HJX47_RS14205 ENOG4105DWT malate dehydrogenase (quinone) HJX47_RS14210 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HJX47_RS14220 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HJX47_RS14225 ENOG4108MRH transcriptional regulatory protein HJX47_RS14245 ENOG4107GFK fumarate HJX47_RS14255 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HJX47_RS14260 ENOG4105F2Z 3-oxoadipate enol-lactonase HJX47_RS14265 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HJX47_RS14270 ENOG4105CHU acetyl-coa acetyltransferase HJX47_RS14275 ENOG4107QNJ CoA-transferase subunit B HJX47_RS14285 ENOG4107HP6 Transcriptional regulator HJX47_RS14290 ENOG4108DG9 Smr protein MutS2 HJX47_RS14295 ENOG4106KR7 LysR family Transcriptional regulator HJX47_RS14305 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HJX47_RS14310 ENOG4105CFC Transporter HJX47_RS14320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJX47_RS14325 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HJX47_RS14330 ENOG4105Q9Y Universal stress protein HJX47_RS14335 ENOG410671Z uncharacterized protein ydiH HJX47_RS14340 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HJX47_RS14345 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HJX47_RS14360 ENOG4105C5D exported protein HJX47_RS14365 ENOG4105D5Q Arginine ornithine antiporter HJX47_RS14370 ENOG410642E Short chain dehydrogenase HJX47_RS14375 ENOG4105RA2 Membrane HJX47_RS14380 ENOG4107EXC regulatoR HJX47_RS14390 ENOG4105JJR Histidine kinase HJX47_RS14400 ENOG4105C9Q fumarate hydratase class II HJX47_RS14405 ENOG4107GFK fumarate HJX47_RS14410 ENOG4105EIP mannose-6-phosphate isomerase HJX47_RS14415 ENOG4106J39 exported protein HJX47_RS14420 ENOG4107P2S Transcriptional regulator HJX47_RS14425 ENOG4105CI1 PTS System HJX47_RS14430 ENOG4105C87 Aminotransferase class I and II HJX47_RS14440 ENOG41061EV selenium-binding protein YdfZ HJX47_RS14455 ENOG41066VF YeeE YedE family protein HJX47_RS14465 ENOG41064WM Uncharacterized protein YcgX HJX47_RS14470 ENOG4105VPI YqaE family transport protein HJX47_RS14475 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJX47_RS14480 ENOG4105C26 Dehydrogenase HJX47_RS14490 ENOG4107DB1 DUF218 domain HJX47_RS14495 ENOG4105CSH Transporter HJX47_RS14505 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HJX47_RS14510 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HJX47_RS14515 ENOG4105C26 Dehydrogenase HJX47_RS14520 ENOG4105F4X arginine HJX47_RS14525 ENOG4105C8Y Acetylornithine aminotransferase HJX47_RS14540 ENOG4105D82 Glutamate dehydrogenase HJX47_RS14545 ENOG4108FN7 Aldo keto reductase HJX47_RS14550 ENOG410642W LysR family Transcriptional regulator HJX47_RS14570 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJX47_RS14580 ENOG4105CQ7 ATP-dependent helicase HJX47_RS14585 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HJX47_RS14595 ENOG4108Z0R Transferase HJX47_RS14600 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HJX47_RS14605 ENOG4105DZS Phenylacetate-CoA ligase HJX47_RS14610 ENOG4105CHU acetyl-coa acetyltransferase HJX47_RS14615 ENOG4108ZJI phenylacetic acid degradation protein HJX47_RS14620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HJX47_RS14625 ENOG4108UKI Enoyl-CoA hydratase HJX47_RS14630 ENOG4105E39 Enoyl-CoA hydratase HJX47_RS14635 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJX47_RS14640 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HJX47_RS14645 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HJX47_RS14650 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HJX47_RS14655 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HJX47_RS14660 ENOG4105DXM phenylacetic acid degradation protein HJX47_RS14665 ENOG4105F11 amine oxidase HJX47_RS14680 ENOG4105CWC Acetylornithine deacetylase HJX47_RS14690 ENOG4105KME endoribonuclease L-psp HJX47_RS14695 ENOG4105H3G oxidoreductase HJX47_RS14700 ENOG4108KB2 LysR family Transcriptional regulator HJX47_RS14715 ENOG4105EAB amino acid AbC transporter HJX47_RS14730 ENOG4105C26 Dehydrogenase HJX47_RS14735 ENOG4108WFR AraC Family Transcriptional Regulator HJX47_RS14740 ENOG4105WXT Conserved Protein HJX47_RS14745 ENOG410689M (LipO)protein HJX47_RS14750 ENOG4107H52 Dicarboxylate transport HJX47_RS14755 ENOG4108KF1 Membrane HJX47_RS14760 ENOG4105C5I Dehydrogenase HJX47_RS14765 ENOG41090X5 Heat shock protein hslJ HJX47_RS14770 ENOG4105IKK cytoplasmic protein HJX47_RS14775 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HJX47_RS14780 ENOG4105FCK Membrane HJX47_RS14790 ENOG4108RW8 Universal stress protein F HJX47_RS14800 ENOG4105C1J atp-dependent rna helicase HJX47_RS14805 ENOG4107RX3 Mg2 transporter protein cora family protein HJX47_RS14810 ENOG4105E98 transcriptional regulator DeoR family HJX47_RS14815 ENOG4105D9R oxidoreductase HJX47_RS14830 ENOG4105C85 amino acid HJX47_RS14835 ENOG4105F7P transcriptional regulator AsnC family HJX47_RS14845 ENOG4105CGF Aromatic amino acid aminotransferase HJX47_RS14850 ENOG4108UMI ABC transporter, permease HJX47_RS14860 ENOG4105D01 (LipO)protein HJX47_RS14900 ENOG4105HEI LysR family (Transcriptional regulator HJX47_RS14925 ENOG4108XFH Transcriptional regulator HJX47_RS14930 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HJX47_RS15010 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJX47_RS15020 ENOG4108ZG0 Ompa motb domain protein HJX47_RS15050 ENOG4108Z0Z intracellular protease Pfpi family HJX47_RS15065 ENOG4105CBN LysR family transcriptional regulator HJX47_RS15090 ENOG4107RTG Major Facilitator superfamily HJX47_RS15095 ENOG4105ENX hydrolase HJX47_RS15100 ENOG4105EQ2 LysR family Transcriptional regulator HJX47_RS15115 ENOG4107QSI ABC, transporter HJX47_RS15125 ENOG4105KXI murein peptide amidase A HJX47_RS15130 ENOG4107S8C mandelate racemase muconate lactonizing HJX47_RS15135 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HJX47_RS15140 ENOG4108KK1 membrane protein AbrB duplication HJX47_RS15145 ENOG4108JU8 Transcriptional regulator HJX47_RS15150 ENOG4105F8D glycoside hydrolase family 4 HJX47_RS15155 ENOG4105W8I Transcriptional regulator HJX47_RS15160 ENOG4106K28 UPF0283 membrane protein HJX47_RS15165 ENOG4105CM6 amino acid regulated cytosolic protein HJX47_RS15170 ENOG4105NNG Peripheral inner membrane phage-shock protein HJX47_RS15175 ENOG4105FM1 phage shock protein C HJX47_RS15180 ENOG4105YYT phage shock protein B HJX47_RS15185 ENOG41087YS Phage shock protein A HJX47_RS15190 ENOG4105E51 psp operon transcriptional activator HJX47_RS15200 ENOG4105CH2 amidohydrolase HJX47_RS15205 ENOG41063ZK Transcriptional Regulator AraC Family HJX47_RS15220 ENOG4108J59 Extracellular solute-binding protein, family 5 HJX47_RS15225 ENOG4108EKA peptide transport system, permease HJX47_RS15230 ENOG4108EU3 peptide transport system, permease HJX47_RS15235 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HJX47_RS15240 ENOG4108JQ2 peptide transport system atp-binding protein HJX47_RS15245 ENOG4105ETS cytosine purines uracil thiamine allantoin HJX47_RS15255 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HJX47_RS15260 ENOG4105Q4T oxidoreductase HJX47_RS15265 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HJX47_RS15275 ENOG4105N2W Transcriptional regulator HJX47_RS15285 ENOG41061RM osmotically inducible lipoprotein HJX47_RS15290 ENOG4108ZJT translation initiation factor, Sui1 HJX47_RS15300 ENOG4105CFV Tetratricopeptide repeat protein HJX47_RS15305 ENOG4105Q4A inner membrane protein yciS HJX47_RS15310 ENOG4105EYK Phosphatidylglycerophosphatase B HJX47_RS15315 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HJX47_RS15320 ENOG4107QM5 aconitate hydratase HJX47_RS15330 ENOG4107R11 Transcriptional regulator HJX47_RS15335 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HJX47_RS15340 ENOG4105RKX Protein of unknown function (DUF2498) HJX47_RS15345 ENOG4105ERU peptidase HJX47_RS15355 ENOG4105UBK short-chain dehydrogenase reductase HJX47_RS15360 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HJX47_RS15380 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HJX47_RS15390 ENOG4105ETT transcriptional Regulator, LysR family HJX47_RS15400 ENOG4107RTD sua5 ycio yrdc ywlc family protein HJX47_RS15405 ENOG4105DB7 PHP domain protein HJX47_RS15410 ENOG4105CRQ synthase (Component I) HJX47_RS15415 ENOG4108EFP Anthranilate synthase component II HJX47_RS15420 ENOG4105DK0 Indole-3-glycerol phosphate synthase HJX47_RS15425 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HJX47_RS15430 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HJX47_RS15455 ENOG4108IU3 tonb-dependent siderophore receptor HJX47_RS15460 ENOG4107E2E PKHD-type hydroxylase HJX47_RS15465 ENOG4105EIF outer membrane protein W HJX47_RS15470 ENOG4105PI0 Ferredoxin HJX47_RS15475 ENOG4108S3I UPF0259 membrane protein HJX47_RS15480 ENOG4107835 probably involved in intracellular septation (By similarity) HJX47_RS15485 ENOG4107RNH Outer membrane receptor FepA HJX47_RS15490 ENOG4105NAU thioesterase Superfamily protein HJX47_RS15495 ENOG4107PN8 YfeABCD locus regulator HJX47_RS15500 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HJX47_RS15505 ENOG4105CHR reductase HJX47_RS15510 ENOG4107K5X Membrane-bound metal-dependent hydrolase HJX47_RS15515 ENOG4108ETY sodium dicarboxylate symporter HJX47_RS15520 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HJX47_RS15525 ENOG4105CH6 catalase HJX47_RS15530 ENOG410901P UPF0249 protein HJX47_RS15535 ENOG4105F8D glycoside hydrolase family 4 HJX47_RS15540 ENOG4105EZV Transcriptional regulator HJX47_RS15545 ENOG4105VCP PTS System HJX47_RS15550 ENOG4105CK1 PTS System HJX47_RS15560 ENOG4105VZJ PTS System HJX47_RS15565 ENOG4105KKI DNA-binding transcriptional activator OsmE HJX47_RS15575 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HJX47_RS15580 ENOG4108SPG Periplasmic Protein HJX47_RS15590 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HJX47_RS15595 ENOG4105C26 Dehydrogenase HJX47_RS15600 ENOG4105F4X arginine HJX47_RS15610 ENOG4105CGK Exodeoxyribonuclease III HJX47_RS15615 ENOG4108RSN SNARE associated Golgi HJX47_RS15620 ENOG4108N5C SNARE associated Golgi protein-related protein HJX47_RS15625 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HJX47_RS15630 ENOG4105VNH ABC transporter solute-binding protein HJX47_RS15635 ENOG4105CXZ ABC transporter, permease HJX47_RS15640 ENOG4108VGW abc transporter atp-binding protein HJX47_RS15645 ENOG4107RM6 sulfurtransferase HJX47_RS15650 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HJX47_RS15655 ENOG4105M6F mutator MutT protein HJX47_RS15660 ENOG4105D82 Glutamate dehydrogenase HJX47_RS15670 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HJX47_RS15675 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HJX47_RS15680 ENOG4105SBG acid phosphatase HJX47_RS15685 ENOG41069NU Nitroreductase HJX47_RS15690 ENOG4105D07 Signal peptide peptidase, SppA HJX47_RS15695 ENOG4105HDK L-asparaginase HJX47_RS15700 ENOG4108RWI nicotinamidase HJX47_RS15710 ENOG4105N1F Hnh endonuclease HJX47_RS15715 ENOG4105VUT cytoplasmic protein HJX47_RS15720 ENOG4105E0X reductase HJX47_RS15725 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJX47_RS15730 ENOG4105DSB aldose 1-epimerase HJX47_RS15735 ENOG4105CV8 reductase HJX47_RS15740 ENOG4105GNX MltA-interacting MipA family protein HJX47_RS15745 ENOG4105CYN Serine protein kinase HJX47_RS15750 ENOG4106AKX UPF0229 protein HJX47_RS15760 ENOG4108V06 Glutathione peroxidase HJX47_RS15780 ENOG4105F27 Major Facilitator HJX47_RS15785 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HJX47_RS15790 ENOG4105CBN LysR family transcriptional regulator HJX47_RS15795 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HJX47_RS15800 ENOG4105KT5 UmuD protein HJX47_RS15805 ENOG4105EKQ RNA-directed DNA polymerase HJX47_RS15810 ENOG4105Y50 Virulence Protein HJX47_RS15815 ENOG4108XNZ glycosyl transferase HJX47_RS15820 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HJX47_RS15825 ENOG4108VMM UPF0756 membrane protein HJX47_RS15830 ENOG4105R1U AraC Family Transcriptional Regulator HJX47_RS15835 ENOG4105DJ2 Major Facilitator Superfamily HJX47_RS15840 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HJX47_RS15845 ENOG4105EWC Purine nucleoside phosphorylase HJX47_RS15850 ENOG4105K78 MarR family Transcriptional regulator HJX47_RS15855 ENOG4105UCG Domain of unknown function (DUF333) HJX47_RS15860 ENOG410620I Diguanylate cyclase HJX47_RS15865 ENOG4106G4W HJX47_RS15880 ENOG4105S5I Membrane HJX47_RS15885 ENOG4108NIW Leucine export protein LeuE HJX47_RS15890 ENOG4105D1S lipid A biosynthesis HJX47_RS15905 ENOG4105DHT Metal Dependent Phosphohydrolase HJX47_RS15910 ENOG4106TD9 Diguanylate cyclase HJX47_RS15915 ENOG4107RSM transcriptional regulator HJX47_RS15920 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJX47_RS15950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJX47_RS15955 ENOG4105C4M (Ubiquinol oxidase) subunit I HJX47_RS15965 ENOG4108N8X transition metal ion binding HJX47_RS15970 ENOG4108Z9Z response to DNA damage stimulus HJX47_RS15985 ENOG4105E2A Dehydrogenase HJX47_RS15990 ENOG4105XDF Protein of unknown function (DUF1272) HJX47_RS16010 ENOG4108ZHR arsR family transcriptional regulator HJX47_RS16015 ENOG4108HMX isocitrate dehydrogenase (NADP) HJX47_RS16030 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HJX47_RS16035 ENOG41075W9 High frequency lysogenization protein HflD homolog HJX47_RS16040 ENOG4107QTF adenylosuccinate lyase HJX47_RS16060 ENOG4105IFJ Histidine kinase HJX47_RS16065 ENOG4105EZE Cupin 4 family protein HJX47_RS16085 ENOG4105D38 putrescine abc transporter HJX47_RS16090 ENOG4108HM4 ABC transporter HJX47_RS16100 ENOG4105CEY Amp-dependent synthetase and ligase HJX47_RS16105 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJX47_RS16110 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJX47_RS16115 ENOG4108YZG isomerase HJX47_RS16120 ENOG4105VI0 Pts system, glucitol sorbitol-specific HJX47_RS16125 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HJX47_RS16130 ENOG4105G63 Type III effector Hrp-dependent HJX47_RS16145 ENOG4105DKT Transcriptional regulator HJX47_RS16155 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HJX47_RS16160 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HJX47_RS16165 ENOG4105D60 lipoprotein releasing system transmembrane protein HJX47_RS16170 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HJX47_RS16175 ENOG4105D60 lipoprotein releasing system transmembrane protein HJX47_RS16185 ENOG4108JA2 transcriptioN-repair coupling factor HJX47_RS16190 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJX47_RS16195 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HJX47_RS16205 ENOG4108IND Tetr family transcriptional regulator HJX47_RS16220 ENOG4107MBR 17 kDa surface antigen HJX47_RS16225 ENOG4105CEP NADH dehydrogenase HJX47_RS16230 ENOG4105D0Y UPF0227 protein HJX47_RS16245 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HJX47_RS16250 ENOG41090DQ Lipoprotein HJX47_RS16255 ENOG4105K59 histidine triad (HIT) protein HJX47_RS16260 ENOG4105CI1 PTS System HJX47_RS16265 ENOG4105F8V Hydrolase, tatD family HJX47_RS16270 ENOG4107QRG dna polymerase iii HJX47_RS16275 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HJX47_RS16280 ENOG4105HHA aminodeoxychorismate lyase HJX47_RS16285 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HJX47_RS16290 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJX47_RS16295 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HJX47_RS16300 ENOG4105CHR reductase HJX47_RS16305 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HJX47_RS16310 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HJX47_RS16315 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HJX47_RS16320 ENOG4105VGS 50s ribosomal protein l32 HJX47_RS16325 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HJX47_RS16330 ENOG4108UHJ MAF-like protein HJX47_RS16335 ENOG4105EI2 Pseudouridine synthase HJX47_RS16345 ENOG4107QQB Ribonuclease E HJX47_RS16350 ENOG4105CR8 Transcriptional regulator HJX47_RS16355 ENOG4105EQ0 Major Facilitator superfamily HJX47_RS16360 ENOG4105CJR Integral membrane protein (MviN HJX47_RS16365 ENOG4105EP9 oxidoreductase HJX47_RS16370 ENOG4108YXG UPF0502 protein HJX47_RS16375 ENOG4105D9U N-acetyltransferase HJX47_RS16380 ENOG4105EV4 Multidrug resistance protein mdtH HJX47_RS16385 ENOG4105F3T (LipO)protein HJX47_RS16390 ENOG4105EKE dihydroorotase HJX47_RS16395 ENOG4105MEA DNA damage-inducible protein i HJX47_RS16400 ENOG4105PVA Biofilm formation regulatory protein BssS HJX47_RS16410 ENOG4106974 biofilm formation HJX47_RS16425 ENOG4105D1S lipid A biosynthesis HJX47_RS16435 ENOG4108W47 Acidic protein msyB HJX47_RS16440 ENOG4105NAC (LipO)protein HJX47_RS16445 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HJX47_RS16455 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HJX47_RS16470 ENOG4108UQ5 membrane protein YcdZ HJX47_RS16475 ENOG4107XHZ cytoplasmic chaperone TorD family protein HJX47_RS16485 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HJX47_RS16505 ENOG4105XEA Tetr family transcriptional regulator HJX47_RS16510 ENOG4105HEI LysR family (Transcriptional regulator HJX47_RS16515 ENOG4105EUB pirin domain protein HJX47_RS16520 ENOG4105CHJ isochorismatase hydrolase HJX47_RS16530 ENOG4108Z33 Thiol disulfide Interchange Protein HJX47_RS16535 ENOG4105D5M phosphate starvation-inducible protein HJX47_RS16540 ENOG4105DBE peroxidase HJX47_RS16545 ENOG410650H (LipO)protein HJX47_RS16555 ENOG4105D9N nucleoside HJX47_RS16570 ENOG4105CK7 Sodium proline symporter HJX47_RS16575 ENOG4105C26 Dehydrogenase HJX47_RS16585 ENOG4108R86 Transcriptional regulator HJX47_RS16590 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HJX47_RS16595 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HJX47_RS16600 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HJX47_RS16605 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HJX47_RS16610 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HJX47_RS16615 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HJX47_RS16620 ENOG4105C2W permease HJX47_RS16630 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HJX47_RS16645 ENOG4105XH3 HJX47_RS16650 ENOG4105D6F Phosphatase HJX47_RS16660 ENOG4105CHR reductase HJX47_RS16675 ENOG4105CUB amino acid HJX47_RS16680 ENOG4105CFQ glutamine synthetase HJX47_RS16685 ENOG4108Z86 Glutamine amidotransferase HJX47_RS16690 ENOG4107VRI Transcriptional regulator HJX47_RS16695 ENOG4105C26 Dehydrogenase HJX47_RS16700 ENOG4105CJP fad dependent oxidoreductase HJX47_RS16705 ENOG4105EJC lysr family transcriptional regulator HJX47_RS16710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HJX47_RS16715 ENOG4105C94 Transporter HJX47_RS16720 ENOG4105DVW rieske (2Fe-2S) HJX47_RS16725 ENOG4105C26 Dehydrogenase HJX47_RS16730 ENOG4105E3J oxidoreductase HJX47_RS16750 ENOG4107QSI ABC, transporter HJX47_RS16755 ENOG4108MN8 Membrane HJX47_RS16765 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HJX47_RS16770 ENOG4108UQN AraC family transcriptional regulator HJX47_RS16775 ENOG4108V1U phospholipid-binding protein HJX47_RS16780 ENOG4105DR4 Methyltransferase HJX47_RS16785 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HJX47_RS16790 ENOG4105K4P CoA-binding domain protein HJX47_RS16800 ENOG41088T4 Helicase IV HJX47_RS16805 ENOG410901E Membrane HJX47_RS16810 ENOG4105EM2 membrane HJX47_RS16815 ENOG4108RZ1 DNA transformation protein HJX47_RS16820 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HJX47_RS16825 ENOG4105UYK outer membrane protein a HJX47_RS16830 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HJX47_RS16835 ENOG4105DAN ATP-dependent protease HJX47_RS16840 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HJX47_RS16845 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HJX47_RS16850 ENOG4108Q2G (LipO)protein HJX47_RS16855 ENOG4105DY2 Paraquat-inducible protein b HJX47_RS16860 ENOG4105F1S paraquat-inducible protein a HJX47_RS16865 ENOG4105C5H ABC transporter HJX47_RS16870 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HJX47_RS16875 ENOG4105QVC MOSC domain-containing protein HJX47_RS16880 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HJX47_RS16890 ENOG4108UZX fmn reductase HJX47_RS16895 ENOG4105GVF (ABC) transporter HJX47_RS16900 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJX47_RS16905 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HJX47_RS16915 ENOG4105CD8 aminopeptidase N HJX47_RS16920 ENOG4107RH7 Nicotinate phosphoribosyltransferase HJX47_RS16925 ENOG4105CH2 amidohydrolase HJX47_RS16930 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HJX47_RS16935 ENOG4105C44 Serine transporter HJX47_RS16940 ENOG4107RCH Diaminopropionate ammonia-lyase HJX47_RS16950 ENOG4105C5S asparaginyl-tRNA synthetase HJX47_RS16955 ENOG4105ZIT Porin Gram-negative type HJX47_RS16960 ENOG4105CGF Aromatic amino acid aminotransferase HJX47_RS16965 ENOG4105C5X domain protein HJX47_RS16970 ENOG4105EAQ (twin-arginine translocation) pathway signal HJX47_RS16975 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HJX47_RS16980 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HJX47_RS16985 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HJX47_RS16990 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HJX47_RS16995 ENOG4106371 Methyltransferase HJX47_RS17000 ENOG4107S90 membrAne HJX47_RS17005 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HJX47_RS17010 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HJX47_RS17015 ENOG4105W49 UPF0434 protein HJX47_RS17020 ENOG4105T0Z Conserved Protein HJX47_RS17025 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HJX47_RS17030 ENOG4105BZ1 (ABC) transporter HJX47_RS17035 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HJX47_RS17040 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HJX47_RS17045 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HJX47_RS17050 ENOG4105CAT Cytidine monophosphate kinase HJX47_RS17055 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HJX47_RS17060 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HJX47_RS17065 ENOG4107VMU Membrane HJX47_RS17070 ENOG4105DDY UPF0142 protein ycaO HJX47_RS17075 ENOG4105TMB Formate nitrite transporter HJX47_RS17080 ENOG4105C6N Formate acetyltransferase HJX47_RS17085 ENOG4105F1A Pyruvate formate-lyase HJX47_RS17090 ENOG4108ISG Major Facilitator HJX47_RS17100 ENOG4107KGK dmso reductase anchor subunit HJX47_RS17105 ENOG4105QAX Iron-sulfur HJX47_RS17110 ENOG4107QY8 reductase HJX47_RS17115 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HJX47_RS17120 ENOG4105D1H recombination factor protein RarA HJX47_RS17125 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HJX47_RS17130 ENOG4105CNU cell division protein FtsK HJX47_RS17135 ENOG4105EW9 transcriptional regulator AsnC family HJX47_RS17145 ENOG4105C3M thioredoxin reductase HJX47_RS17150 ENOG4108JJ9 ABC, transporter HJX47_RS17155 ENOG4108JJ8 (ABC) transporter HJX47_RS17160 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HJX47_RS17165 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HJX47_RS17170 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJX47_RS17175 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HJX47_RS17180 ENOG4105VEQ Cold shock protein HJX47_RS17190 ENOG4105DJY efflux transporter, rnd family, mfp subunit HJX47_RS17195 ENOG4105CPB ATP-dependent endonuclease of the OLD family HJX47_RS17200 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJX47_RS17205 ENOG4105DWU Membrane HJX47_RS17215 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJX47_RS17225 ENOG4105C7K acetolactate synthase HJX47_RS17230 ENOG4105C5W Aldolase HJX47_RS17235 ENOG4105CGD Nad-dependent epimerase dehydratase HJX47_RS17240 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HJX47_RS17245 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HJX47_RS17255 ENOG41064MM (LipO)protein HJX47_RS17260 ENOG4105E5Z arginine transporter ATP-binding subunit HJX47_RS17265 ENOG4106PMH Extracellular solute-binding protein family 3 HJX47_RS17270 ENOG4105GBT ABC transporter HJX47_RS17275 ENOG4105DMR ABC, transporter HJX47_RS17280 ENOG4106TNF Periplasmic binding protein HJX47_RS17285 ENOG4105BZU Histidine kinase HJX47_RS17290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJX47_RS17295 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HJX47_RS17300 ENOG4105RBQ inner membrane protein ybjO HJX47_RS17305 ENOG4105D38 putrescine abc transporter HJX47_RS17310 ENOG4105F38 ABC transporter, permease HJX47_RS17315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS17320 ENOG4107RUE extracellular solute-binding protein family 1 HJX47_RS17325 ENOG4108RMJ sensory transduction regulator HJX47_RS17335 ENOG4108DBC nitroreductase HJX47_RS17340 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HJX47_RS17345 ENOG41090BQ Glutaredoxin HJX47_RS17350 ENOG4105GWF inner membrane protein YbjM HJX47_RS17355 ENOG4105D0C transport protein HJX47_RS17365 ENOG4108RFG Tetr family transcriptional regulator HJX47_RS17370 ENOG4106UW1 Major Facilitator superfamily HJX47_RS17375 ENOG4108HCJ Hydrolase HJX47_RS17380 ENOG4107QF7 multi-drug HJX47_RS17385 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HJX47_RS17390 ENOG4107FB0 transcriptional regulator DeoR family HJX47_RS17395 ENOG4105DZ1 carboxypeptidase HJX47_RS17405 ENOG4108TGY Glutathione S-transferase HJX47_RS17410 ENOG4105D8V Glucose sorbosone dehydrogenase HJX47_RS17415 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HJX47_RS17420 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJX47_RS17425 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HJX47_RS17430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJX47_RS17435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJX47_RS17440 ENOG4105DEF Extracellular solute-binding protein, family 5 HJX47_RS17445 ENOG4108JQ6 ABC transporter HJX47_RS17450 ENOG4105D44 asparaginase HJX47_RS17455 ENOG4105CVM Molybdenum cofactor synthesis domain protein HJX47_RS17460 ENOG4105D06 uba thif-type nad fad binding protein HJX47_RS17465 ENOG4105F1A Pyruvate formate-lyase HJX47_RS17475 ENOG4108HCJ Hydrolase HJX47_RS17480 ENOG41072TH Protein of unknown function (DUF1479) HJX47_RS17485 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS17490 ENOG4105DPW Major facilitator superfamily MFS_1 HJX47_RS17500 ENOG4105C5H ABC transporter HJX47_RS17505 ENOG4105M2Z protein tyrosine serine phosphatase HJX47_RS17510 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJX47_RS17515 ENOG4108TZY GntR Family Transcriptional Regulator HJX47_RS17520 ENOG4105CS2 ec 3.2.1.21 HJX47_RS17525 ENOG4105F4P )-transporter HJX47_RS17530 ENOG4105KST dependent repressor HJX47_RS17540 ENOG4108I6E Sulfatase HJX47_RS17545 ENOG4108T1M outer membrane protein x HJX47_RS17560 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HJX47_RS17565 ENOG4107R0W ABC transporter HJX47_RS17570 ENOG4105E5Q amino acid AbC transporter HJX47_RS17575 ENOG4105CDA abc transporter atp-binding protein HJX47_RS17580 ENOG4105D8X mechanosensitive ion channel HJX47_RS17585 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HJX47_RS17590 ENOG4105EW6 flavin reductase domain protein, FMN-binding HJX47_RS17600 ENOG4105KSC Transcriptional regulator, TraR DksA family HJX47_RS17605 ENOG4105VR4 UPF0379 protein ybiJ HJX47_RS17610 ENOG4108MTB glycosyl transferase family HJX47_RS17615 ENOG4105DVT helicase HJX47_RS17620 ENOG4105C1J atp-dependent rna helicase HJX47_RS17640 ENOG4105DJB Major Facilitator Superfamily HJX47_RS17650 ENOG4108PZW LysR family Transcriptional regulator HJX47_RS17655 ENOG4107MVR Transcriptional regulator HJX47_RS17660 ENOG4105D0S secretion protein (HlyD HJX47_RS17665 ENOG4105CJ1 ABC, transporter HJX47_RS17670 ENOG4107QWP ABC-2 type transporter HJX47_RS17675 ENOG4107QWP ABC-2 type transporter HJX47_RS17680 ENOG4105I9U inner membrane protein ybhQ HJX47_RS17685 ENOG4105X23 Endonuclease Exonuclease phosphatase HJX47_RS17690 ENOG4105DZQ phospholipase D Transphosphatidylase HJX47_RS17695 ENOG4107UXM Membrane HJX47_RS17700 ENOG4105HFZ Membrane HJX47_RS17705 ENOG4108ZAF Molybdopterin HJX47_RS17710 ENOG4105M00 molybdopterin converting factor, subunit 1 HJX47_RS17715 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HJX47_RS17720 ENOG4108RIR Molybdenum cofactor biosynthesis protein HJX47_RS17725 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HJX47_RS17730 ENOG4105CHW UPF0052 protein HJX47_RS17735 ENOG4105DIJ Phosphoethanolamine transferase HJX47_RS17740 ENOG4105XJC Two component transcriptional regulator (Winged helix family HJX47_RS17745 ENOG4105ECM Sensor protein basS pmrB HJX47_RS17750 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HJX47_RS17760 ENOG4108IV0 ABC, transporter HJX47_RS17770 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HJX47_RS17775 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HJX47_RS17780 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HJX47_RS17785 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HJX47_RS17790 ENOG4108V1U phospholipid-binding protein HJX47_RS17795 ENOG4105C85 amino acid HJX47_RS17800 ENOG4105C84 Histidine ammonia-lyase HJX47_RS17805 ENOG4105CGP Urocanate hydratase HJX47_RS17820 ENOG41088SP formiminoglutamate hydrolase HJX47_RS17825 ENOG4105CI2 imidazolone-5-propionate hydrolase HJX47_RS17830 ENOG4105NBR Pectinesterase HJX47_RS17840 ENOG4108U51 Universal stress protein HJX47_RS17845 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJX47_RS17880 ENOG4108XDN Transcriptional regulator HJX47_RS17885 ENOG4105BZU Histidine kinase HJX47_RS17890 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HJX47_RS17905 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HJX47_RS17910 ENOG4108K4B hydrolase HJX47_RS17920 ENOG4105E0C molybdate abc transporter HJX47_RS17925 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HJX47_RS17935 ENOG4105F4R Transcriptional regulator mode HJX47_RS17945 ENOG4105DKW ABC transporter HJX47_RS17955 ENOG4105CMR udp-glucose 4-epimerase HJX47_RS17960 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HJX47_RS17965 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HJX47_RS17970 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HJX47_RS17975 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HJX47_RS17980 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJX47_RS17985 ENOG4105JND homeobox protein HJX47_RS17990 ENOG4105PGM cation diffusion facilitator family transporter HJX47_RS17995 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HJX47_RS18000 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HJX47_RS18050 ENOG4105UFD tol-pal system protein YbgF HJX47_RS18055 ENOG4105KCK Peptidoglycan-associated lipoprotein HJX47_RS18065 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HJX47_RS18075 ENOG4105E02 MotA TolQ exbB proton channel HJX47_RS18080 ENOG4107YD3 Thioesterase HJX47_RS18085 ENOG4105KJB cyd operon protein YbgE HJX47_RS18095 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJX47_RS18100 ENOG4105C4M (Ubiquinol oxidase) subunit I HJX47_RS18110 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HJX47_RS18115 ENOG4105CMV Succinyl-CoA synthetase subunit beta HJX47_RS18120 ENOG4105C7S Dehydrogenase HJX47_RS18125 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HJX47_RS18130 ENOG4105E33 succinate dehydrogenase HJX47_RS18135 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HJX47_RS18140 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HJX47_RS18145 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HJX47_RS18150 ENOG4105BZN citrate synthase HJX47_RS18155 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HJX47_RS18175 ENOG4105E7W lamb ycsf family protein HJX47_RS18180 ENOG4107R7A Allophanate hydrolase subunit 2 HJX47_RS18185 ENOG4105P4J Allophanate hydrolase, subunit 1 HJX47_RS18190 ENOG4107QNR UPF0135 protein HJX47_RS18195 ENOG4105DUX Transporter HJX47_RS18200 ENOG4105CVP deoxyribo-dipyrimidine photolyase HJX47_RS18205 ENOG4105XIQ Protein of unknown function (DUF2517) HJX47_RS18215 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HJX47_RS18220 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HJX47_RS18225 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HJX47_RS18230 ENOG4105C08 Histidine kinase HJX47_RS18235 ENOG4105EEX Two component transcriptional regulator (Winged helix family HJX47_RS18245 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HJX47_RS18250 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HJX47_RS18255 ENOG4105EV9 Alpha Beta Hydrolase HJX47_RS18260 ENOG4105NNH LexA regulated protein HJX47_RS18265 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HJX47_RS18270 ENOG41090R7 Ferric uptake HJX47_RS18280 ENOG4105GX6 (LipO)protein HJX47_RS18295 ENOG4105CX6 glutaminyL-tRNA synthetase HJX47_RS18300 ENOG4105CI1 PTS System HJX47_RS18305 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HJX47_RS18310 ENOG4105CE4 GlcNAc 6-P deacetylase HJX47_RS18315 ENOG4105E2R ROK family HJX47_RS18320 ENOG4105D4U had-superfamily hydrolase, subfamily iia HJX47_RS18325 ENOG4105CAQ asparagine synthetase HJX47_RS18365 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HJX47_RS18370 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HJX47_RS18375 ENOG4105C9A Phoh family HJX47_RS18380 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HJX47_RS18385 ENOG4108JU5 Magnesium and cobalt efflux protein HJX47_RS18390 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HJX47_RS18395 ENOG4107RP9 extracellular solute-binding protein, family 3 HJX47_RS18400 ENOG4105EAD ABC transporter HJX47_RS18405 ENOG4105DRP amino acid AbC transporter HJX47_RS18410 ENOG4105CDA abc transporter atp-binding protein HJX47_RS18425 ENOG4107PAI alpha helical protein HJX47_RS18430 ENOG4105C8T Leucyl-tRNA synthetase HJX47_RS18440 ENOG4105DJF DNA polymerase III, delta' subunit HJX47_RS18445 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HJX47_RS18450 ENOG4108TGR phosphatase HJX47_RS18455 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HJX47_RS18460 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HJX47_RS18465 ENOG4105CJN penicillin-binding protein HJX47_RS18470 ENOG4105CNI cell division protein FtsW HJX47_RS18475 ENOG4105K6T rare lipoprotein A HJX47_RS18480 ENOG4105DZ1 carboxypeptidase HJX47_RS18485 ENOG4108Z43 UPF0250 protein HJX47_RS18490 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HJX47_RS18495 ENOG41064T2 transcriptional regulator, lysR family HJX47_RS18500 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HJX47_RS18505 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HJX47_RS18525 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HJX47_RS18530 ENOG4105CEE C4-dicarboxylate transporter HJX47_RS18535 ENOG4105KTS ribonuclease HJX47_RS18540 ENOG4105NXH GreA GreB family elongation factor HJX47_RS18545 ENOG4108U51 Universal stress protein HJX47_RS18550 ENOG4108JU3 Alkyl hydroperoxide reductase HJX47_RS18555 ENOG4105D3R alkyl hydroperoxide reductase HJX47_RS18560 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HJX47_RS18565 ENOG4105DQS Transcriptional regulator HJX47_RS18570 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HJX47_RS18575 ENOG4105GTN ParB Domain Protein Nuclease HJX47_RS18580 ENOG4105CHM Aminotransferase HJX47_RS18585 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HJX47_RS18590 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HJX47_RS18605 ENOG4105C2J ABC transporter HJX47_RS18615 ENOG4105CNN ABC, transporter HJX47_RS18625 ENOG4108M3J Dehydrogenase HJX47_RS18635 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HJX47_RS18640 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HJX47_RS18650 ENOG4105DZC cytosine deaminase HJX47_RS18660 ENOG4105ECY inositol monophosphatase HJX47_RS18665 ENOG4105CXY transporter HJX47_RS18670 ENOG4105D6F Phosphatase HJX47_RS18675 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HJX47_RS18680 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HJX47_RS18695 ENOG4105CNN ABC, transporter HJX47_RS18700 ENOG4105C2J ABC transporter HJX47_RS18705 ENOG4107SCQ Iron-containing alcohol dehydrogenase HJX47_RS18710 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HJX47_RS18725 ENOG4105VCD cytoplasmic protein HJX47_RS18730 ENOG4105D22 carbon starvation protein HJX47_RS18735 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HJX47_RS18740 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HJX47_RS18745 ENOG4105WQI isochorismatase HJX47_RS18750 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HJX47_RS18755 ENOG4105E4F Isochorismate synthase HJX47_RS18760 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HJX47_RS18765 ENOG4105E8G Major facilitator Superfamily HJX47_RS18770 ENOG4105DQ5 transport system permease protein HJX47_RS18775 ENOG4105TVJ transport system, permease HJX47_RS18780 ENOG4105E0A ABC, transporter HJX47_RS18785 ENOG4105C0W non-ribosomal peptide synthetase HJX47_RS18790 ENOG41085A6 mbth domain-containing protein HJX47_RS18795 ENOG4105E93 esterase HJX47_RS18800 ENOG4107RNH Outer membrane receptor FepA HJX47_RS18805 ENOG4108TSE Transferase HJX47_RS18810 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJX47_RS18820 ENOG4105C2J ABC transporter HJX47_RS18825 ENOG4105CNN ABC, transporter HJX47_RS18830 ENOG4105DNE Transposase HJX47_RS18835 ENOG4105DKT Transcriptional regulator HJX47_RS18840 ENOG4108HHA Transketolase HJX47_RS18845 ENOG4108IUS Transketolase HJX47_RS18855 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HJX47_RS18865 ENOG410810E transcriptional regulator, lysR family HJX47_RS18870 ENOG4105CUY Mechanosensitive ion channel HJX47_RS18875 ENOG4108WN0 inhibitor of vertebrate lysozyme HJX47_RS18880 ENOG4105C94 Transporter HJX47_RS18895 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HJX47_RS18905 ENOG4105DEF Extracellular solute-binding protein, family 5 HJX47_RS18910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJX47_RS18915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJX47_RS18920 ENOG4105C3U ABC transporter HJX47_RS18925 ENOG4108JQ7 (ABC) transporter HJX47_RS18930 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HJX47_RS18935 ENOG4105EMU Dehydrogenase HJX47_RS18945 ENOG4105GBT ABC transporter HJX47_RS18950 ENOG4105DRP amino acid AbC transporter HJX47_RS18955 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HJX47_RS18965 ENOG4105CHM Aminotransferase HJX47_RS18970 ENOG4105T38 integral membrane protein HJX47_RS18975 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HJX47_RS18990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJX47_RS19000 ENOG4108J59 Extracellular solute-binding protein, family 5 HJX47_RS19005 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HJX47_RS19010 ENOG4108T58 Mg2 transport protein CorA HJX47_RS19035 ENOG4105WQ6 Membrane HJX47_RS19040 ENOG4105HFT AraC family transcriptional regulator HJX47_RS19050 ENOG410630P Transcriptional regulator HJX47_RS19055 ENOG4105MSB protein, conserved in bacteria HJX47_RS19070 ENOG4108IQ3 PTS system HJX47_RS19080 ENOG4105F3R pts system mannose fructose sorbose family iid HJX47_RS19085 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HJX47_RS19090 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HJX47_RS19095 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJX47_RS19115 ENOG4105CUY Mechanosensitive ion channel HJX47_RS19120 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS19130 ENOG4105CK5 oxidoreductase HJX47_RS19140 ENOG4105EAA nucleoside HJX47_RS19145 ENOG4105C85 amino acid HJX47_RS19155 ENOG4108NS2 receptor HJX47_RS19160 ENOG4105C26 Dehydrogenase HJX47_RS19165 ENOG4105CJP fad dependent oxidoreductase HJX47_RS19175 ENOG4105CUB amino acid HJX47_RS19190 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HJX47_RS19195 ENOG4105DGU Histone deacetylase HJX47_RS19205 ENOG4108UAJ Transcriptional regulator HJX47_RS19215 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HJX47_RS19230 ENOG4105CPC Aldo Keto reductase HJX47_RS19235 ENOG4105E89 ABC transporter HJX47_RS19240 ENOG4105CH2 amidohydrolase HJX47_RS19275 ENOG4105EHG Permease protein HJX47_RS19280 ENOG4105E0A ABC, transporter HJX47_RS19285 ENOG4105EFX secretion protein, HlyD family HJX47_RS19290 ENOG4105KK7 inner membrane protein YiaW HJX47_RS19305 ENOG4105D7K pfkb domain protein HJX47_RS19310 ENOG4108M0B Sucrose porin HJX47_RS19315 ENOG4105C5Y PTS System HJX47_RS19320 ENOG4108HKT sucrose-6-phosphate hydrolase HJX47_RS19325 ENOG4105WBN Transcriptional regulator (LacI family HJX47_RS19340 ENOG4108HWV )-transporter HJX47_RS19345 ENOG4105C2J ABC transporter HJX47_RS19385 ENOG4105CRK lysyL-tRNA synthetase HJX47_RS19390 ENOG4105DUX Transporter HJX47_RS19395 ENOG4105CXN decarboxylase HJX47_RS19400 ENOG4105D5Q Arginine ornithine antiporter HJX47_RS19405 ENOG4108M3R transcriptional activator CadC HJX47_RS19415 ENOG4105D1S lipid A biosynthesis HJX47_RS19430 ENOG4105CW0 outer membrane usher protein HJX47_RS19435 ENOG4105GQR Chaperone HJX47_RS19440 ENOG4105X0I Fimbrial HJX47_RS19455 ENOG4105BZN citrate synthase HJX47_RS19485 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HJX47_RS19490 ENOG4105WQ3 Rna-binding protein HJX47_RS19495 ENOG4105C8N cysteinyl-tRNA synthetase HJX47_RS19500 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HJX47_RS19505 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HJX47_RS19515 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HJX47_RS19520 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HJX47_RS19540 ENOG4105CV6 ABC transporter, permease HJX47_RS19545 ENOG4108I0Y (ABC) transporter HJX47_RS19550 ENOG4108UJV acyl-CoA thioesterase i HJX47_RS19555 ENOG4105E1F short-chain dehydrogenase reductase HJX47_RS19560 ENOG4107QR8 Thioredoxin HJX47_RS19565 ENOG4105C4B ABC transporter, permease HJX47_RS19570 ENOG41083J0 (ABC) transporter HJX47_RS19575 ENOG4107QX8 SPFH domain, Band 7 family protein HJX47_RS19580 ENOG4105G5H Membrane HJX47_RS19585 ENOG4108Z6Z Transcriptional regulator HJX47_RS19590 ENOG4105C59 p-type ATPase HJX47_RS19595 ENOG4105MBR gumn family HJX47_RS19600 ENOG4108Z66 YbaK ebsC protein HJX47_RS19605 ENOG4105CGH 5'-nucleotidase HJX47_RS19610 ENOG4105EU0 Major facilitator Superfamily HJX47_RS19625 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJX47_RS19630 ENOG4107RE1 Inosine-guanosine kinase HJX47_RS19640 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HJX47_RS19645 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HJX47_RS19650 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HJX47_RS19655 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HJX47_RS19660 ENOG4107QMP dna polymerase iii subunits gamma and tau HJX47_RS19665 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HJX47_RS19670 ENOG4105WD1 Membrane HJX47_RS19675 ENOG4108URS primosomal replication protein n'' HJX47_RS19680 ENOG4106428 Protein of unknown function (DUF2496) HJX47_RS19685 ENOG4105DNE Transposase HJX47_RS19690 ENOG4105EGS Mechanosensitive ion channel HJX47_RS19695 ENOG4107XI7 Tetr family transcriptional regulator HJX47_RS19700 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJX47_RS19705 ENOG4105BZS acriflavin resistance protein HJX47_RS19710 ENOG4108UKR Biofilm formation regulator YbaJ HJX47_RS19720 ENOG4108UW5 maltose o-acetyltransferase HJX47_RS19730 ENOG4105GSJ Inner membrane protein ylaC HJX47_RS19745 ENOG4105YK5 50S ribosomal protein L36 HJX47_RS19755 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS19760 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJX47_RS19765 ENOG4105CI1 PTS System HJX47_RS19770 ENOG4105C4C beta-galactosidase HJX47_RS19780 ENOG4105EG2 ABC transporter, permease HJX47_RS19790 ENOG4107FKK extracellular solute-binding protein family 1 HJX47_RS19805 ENOG41066DG (EAL) domain protein HJX47_RS19810 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HJX47_RS19815 ENOG41061MD high-affinity nickel-transporter HJX47_RS19820 ENOG4108VW9 Membrane HJX47_RS19850 ENOG41080UX Methyltransferase HJX47_RS19855 ENOG4108MNP Glycoprotein polysaccharide metabolism HJX47_RS19860 ENOG4105C29 acyl-CoA thioesterase HJX47_RS19865 ENOG4105BZU Histidine kinase HJX47_RS19870 ENOG4108YZA Nitrogen regulatory protein pii HJX47_RS19875 ENOG4105BZ1 (ABC) transporter HJX47_RS19880 ENOG4105BZ1 (ABC) transporter HJX47_RS19885 ENOG4108XM1 transcriptional regulator AsnC family HJX47_RS19895 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HJX47_RS19900 ENOG4108NFA extracellular solute-binding protein HJX47_RS19905 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HJX47_RS19910 ENOG4108TGP Thioesterase superfamily protein HJX47_RS19915 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HJX47_RS19920 ENOG4105EIN peptidylprolyl cis-trans isomerase HJX47_RS19925 ENOG4105K70 DNA-binding protein HJX47_RS19930 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HJX47_RS19935 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HJX47_RS19945 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HJX47_RS19955 ENOG4105M85 Bola protein HJX47_RS19960 ENOG4105IEY (LipO)protein HJX47_RS19965 ENOG4105EYM Major Facilitator superfamily HJX47_RS19970 ENOG4105E2S oxidase) subunit II HJX47_RS19975 ENOG4105BZ9 Cytochrome C oxidase, subunit I HJX47_RS19980 ENOG4105CCU oxidase (Subunit III) HJX47_RS19985 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HJX47_RS19990 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HJX47_RS20000 ENOG4107HP6 Transcriptional regulator HJX47_RS20005 ENOG4105E2X shikimate dehydrogenase HJX47_RS20010 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HJX47_RS20020 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HJX47_RS20030 ENOG4105D2S major facilitator superfamily HJX47_RS20035 ENOG4105CIB oxidoreductase Domain protein HJX47_RS20040 ENOG4107RDB Major Facilitator HJX47_RS20050 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HJX47_RS20055 ENOG4107S0N DJ-1 family HJX47_RS20065 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HJX47_RS20070 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HJX47_RS20075 ENOG4105CTB Polyprenyl synthetase HJX47_RS20080 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HJX47_RS20085 ENOG4105CPC Aldo Keto reductase HJX47_RS20090 ENOG4108ZAI phosphatidylglycerophosphatase a HJX47_RS20095 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HJX47_RS20100 ENOG4107YIM Involved in the transcription termination process (By similarity) HJX47_RS20105 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HJX47_RS20110 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HJX47_RS20115 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HJX47_RS20120 ENOG4108KIC (LipO)protein HJX47_RS20125 ENOG4105DRB nucleoside-specific channel-forming protein HJX47_RS20140 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HJX47_RS20145 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HJX47_RS20150 ENOG4105VIE preprotein translocase, subunit YajC HJX47_RS20155 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HJX47_RS20160 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HJX47_RS20170 ENOG4108ZYK Acyl carrier protein phosphodiesterase HJX47_RS20175 ENOG4105D3R alkyl hydroperoxide reductase HJX47_RS20180 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HJX47_RS20195 ENOG4108MGF sugar kinase HJX47_RS20205 ENOG4105CI2 imidazolone-5-propionate hydrolase HJX47_RS20215 ENOG4105CHJ isochorismatase hydrolase HJX47_RS20220 ENOG4105EQ1 Transcriptional regulator HJX47_RS20225 ENOG4107R28 alpha amylase, catalytic region HJX47_RS20230 ENOG4105C85 amino acid HJX47_RS20235 ENOG4105CWM branched-chain amino acid transport system II carrier protein HJX47_RS20240 ENOG4105BZU Histidine kinase HJX47_RS20245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJX47_RS20250 ENOG4107RH8 nuclease SbcCD subunit D HJX47_RS20255 ENOG4105EYH Exonuclease HJX47_RS20260 ENOG4105DKQ ROK family HJX47_RS20265 ENOG4105DH7 May be involved in recombination (By similarity) HJX47_RS20270 ENOG4105NBK UPF0345 protein HJX47_RS20275 ENOG4105HBA AroM protein HJX47_RS20280 ENOG4105SS3 HJX47_RS20285 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HJX47_RS20290 ENOG4105G4C Periplasmic ligand-binding sensor protein HJX47_RS20295 ENOG4108UPT UPF0178 protein HJX47_RS20300 ENOG4105II7 pyrroline-5-carboxylate reductase HJX47_RS20305 ENOG4105VIF phosphate starvation-inducible protein HJX47_RS20310 ENOG4105G6Z alkaline phosphatase HJX47_RS20330 ENOG4105CPF Cell wall formation (By similarity) HJX47_RS20335 ENOG4105UNH Membrane HJX47_RS20340 ENOG4105FR5 inner membrane protein YaiY HJX47_RS20345 ENOG4107QS8 (LipO)protein HJX47_RS20350 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HJX47_RS20355 ENOG4108RWI nicotinamidase HJX47_RS20360 ENOG4107R6D beta-lactam binding protein AmpH HJX47_RS20365 ENOG4105D52 delta-aminolevulinic acid dehydratase HJX47_RS20370 ENOG4108UK5 Transposase HJX47_RS20380 ENOG4105E2B Taurine dioxygenase HJX47_RS20385 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HJX47_RS20390 ENOG4108ETV ABC transporter HJX47_RS20395 ENOG4106FTQ Taurine ABC transporter, periplasmic HJX47_RS20400 ENOG4107QK5 Homocysteine s-methyltransferase HJX47_RS20405 ENOG4108IQI permease HJX47_RS20415 ENOG4105C85 amino acid HJX47_RS20420 ENOG4105CPD ethanolamine ammonia-lyase HJX47_RS20425 ENOG4107FQ9 ethanolamine ammonia-lyase HJX47_RS20440 ENOG4105C32 Amino acid ABC transporter (Permease) HJX47_RS20445 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJX47_RS20450 ENOG4105C0Z ABC transporter HJX47_RS20455 ENOG4108IV0 ABC, transporter HJX47_RS20465 ENOG4105CT1 (ABC) transporter HJX47_RS20470 ENOG4105CDA abc transporter atp-binding protein HJX47_RS20475 ENOG4105EZ7 amino acid ABC transporter HJX47_RS20480 ENOG4105DRP amino acid AbC transporter HJX47_RS20490 ENOG4106PYX Receptor HJX47_RS20495 ENOG4108N3D putative enzyme HJX47_RS20500 ENOG4108NN8 Fimbrial protein HJX47_RS20505 ENOG4108GWT fimbrillin MatB HJX47_RS20510 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HJX47_RS20520 ENOG4105EHI Phosphonate ABC transporter, periplasmic HJX47_RS20530 ENOG4105S7S phosphonate abc transporter HJX47_RS20555 ENOG4108QBX (LipO)protein HJX47_RS20560 ENOG4105FCK Membrane HJX47_RS20565 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HJX47_RS20675 ENOG4105DFP Integrase HJX47_RS20710 ENOG4108FZ9 Chaperone HJX47_RS20715 ENOG4106PG1 outer membrane usher protein HJX47_RS20745 ENOG41061ZR Transcriptional regulator HJX47_RS20750 ENOG4107R0V Pyruvate dehydrogenase HJX47_RS20755 ENOG4105CPP Dehydrogenase, E1 component HJX47_RS20765 ENOG4107QN2 dihydrolipoyl dehydrogenase HJX47_RS20775 ENOG41061GT Aldolase HJX47_RS20785 ENOG4105CMG Carbohydrate kinase HJX47_RS20790 ENOG4105CHR reductase HJX47_RS20795 ENOG4108JQ1 Dehydrogenase HJX47_RS20800 ENOG4105DT3 PTS system, galactitol-specific IIc component HJX47_RS20805 ENOG4108TGY Glutathione S-transferase HJX47_RS20810 ENOG4105DTA methyltransferase HJX47_RS20815 ENOG4105YCT UPF0386 protein HJX47_RS20825 ENOG4105D5U fad dependent oxidoreductase HJX47_RS20830 ENOG4105C26 Dehydrogenase HJX47_RS20835 ENOG4108JPW Aminotransferase HJX47_RS20840 ENOG4105C85 amino acid HJX47_RS20845 ENOG4108PVQ transcriptional regulator HJX47_RS20850 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HJX47_RS20855 ENOG4105V1F Fermentation respiration switch protein HJX47_RS20860 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HJX47_RS20865 ENOG4105CIN aminoacyl-histidine dipeptidase HJX47_RS20870 ENOG4108HYG acetyltransferase HJX47_RS20875 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HJX47_RS20890 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HJX47_RS20895 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJX47_RS20900 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJX47_RS20905 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJX47_RS20910 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJX47_RS20915 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJX47_RS20920 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HJX47_RS20925 ENOG4105E7A Glutamine amidotransferase HJX47_RS20930 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HJX47_RS20935 ENOG4107QPN acyl-Coa dehydrogenase HJX47_RS20940 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HJX47_RS20945 ENOG4108VP3 Lysine exporter protein (LysE YggA) HJX47_RS20950 ENOG41090KR LysR family transcriptional Regulator HJX47_RS20960 ENOG4107RZZ dna polymerase iii epsilon subunit HJX47_RS20965 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HJX47_RS20970 ENOG4105D1A Methyltransferase HJX47_RS20975 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HJX47_RS20980 ENOG4105E9H Lytic Murein transglycosylase HJX47_RS20985 ENOG4105F2W methyltransferase HJX47_RS20995 ENOG4105F27 Major Facilitator HJX47_RS21000 ENOG4105HEI LysR family (Transcriptional regulator HJX47_RS21005 ENOG4105CV8 reductase HJX47_RS21040 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HJX47_RS21045 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS21050 ENOG4108UMI ABC transporter, permease HJX47_RS21055 ENOG4105D01 (LipO)protein HJX47_RS21060 ENOG4108R8X outer membrane lipoprotein HJX47_RS21065 ENOG4108R96 Methyltransferase, YaeB family HJX47_RS21070 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HJX47_RS21075 ENOG4108UY0 (LipO)protein HJX47_RS21080 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HJX47_RS21085 ENOG4108YZN class I peptide chain release factor HJX47_RS21090 ENOG4108VWS Yaeq family HJX47_RS21095 ENOG4105W1I UPF0253 protein HJX47_RS21100 ENOG4105M1T rho-binding antiterminator HJX47_RS21105 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HJX47_RS21110 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HJX47_RS21115 ENOG4105CXN decarboxylase HJX47_RS21120 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HJX47_RS21125 ENOG4105C0B DNA polymerase III (alpha subunit) HJX47_RS21130 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HJX47_RS21135 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJX47_RS21140 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJX47_RS21145 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HJX47_RS21150 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJX47_RS21155 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HJX47_RS21160 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJX47_RS21165 ENOG4105DZP Membrane-associated zinc metalloprotease HJX47_RS21170 ENOG4105KNE Phosphatidate cytidylyltransferase HJX47_RS21180 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HJX47_RS21190 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HJX47_RS21195 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HJX47_RS21200 ENOG4105CE9 30S ribosomal protein S2 HJX47_RS21205 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HJX47_RS21210 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HJX47_RS21215 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HJX47_RS21220 ENOG4108T8E UPF0325 protein HJX47_RS21225 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HJX47_RS21230 ENOG4105C0H protease HJX47_RS21235 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HJX47_RS21240 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HJX47_RS21245 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HJX47_RS21250 ENOG4105EN6 Membrane HJX47_RS21255 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HJX47_RS21260 ENOG4105CMQ Chloride channel HJX47_RS21265 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HJX47_RS21270 ENOG4105S6R Iron-hydroxamate transporter permease subunit HJX47_RS21275 ENOG4105J76 Periplasmic binding protein HJX47_RS21280 ENOG4105E0A ABC, transporter HJX47_RS21285 ENOG4105E0K tonB-dependent siderophore receptor HJX47_RS21290 ENOG4105BZ4 penicillin-binding protein HJX47_RS21380 ENOG4105CQ7 ATP-dependent helicase HJX47_RS21385 ENOG4107XID 2'-5' rna ligase HJX47_RS21390 ENOG4105PW4 Sugar fermentation stimulation protein homolog HJX47_RS21395 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HJX47_RS21400 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HJX47_RS21405 ENOG4105DJ0 Poly(A) Polymerase HJX47_RS21410 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HJX47_RS21415 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HJX47_RS21420 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HJX47_RS21425 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HJX47_RS21430 ENOG4107BJW polysaccharide deacetylase HJX47_RS21435 ENOG4108YTN IIa component HJX47_RS21440 ENOG4105E3A (ABC) transporter HJX47_RS21445 ENOG4105DA5 (ABC) transporter HJX47_RS21450 ENOG41077A9 carbonic anhydrase HJX47_RS21455 ENOG4108UGV hypoxanthine phosphoribosyltransferase HJX47_RS21465 ENOG4105DZG Dehydrogenase HJX47_RS21470 ENOG4105E3B Multicopper oxidase HJX47_RS21475 ENOG4108ZRK uncharacterized protein yacC HJX47_RS21495 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HJX47_RS21500 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HJX47_RS21505 ENOG4108ZIG UPF0231 protein HJX47_RS21510 ENOG4107QIJ Aconitate hydratase 2 HJX47_RS21520 ENOG4108NST exported protein HJX47_RS21535 ENOG4107QN2 dihydrolipoyl dehydrogenase HJX47_RS21540 ENOG4107QSN dihydrolipoamide acetyltransferase HJX47_RS21545 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HJX47_RS21550 ENOG41073TP transcriptional regulator HJX47_RS21555 ENOG4105C85 amino acid HJX47_RS21560 ENOG4105CT4 transporter HJX47_RS21565 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HJX47_RS21575 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HJX47_RS21580 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HJX47_RS21585 ENOG4108ZUW Major pilin subunit HJX47_RS21590 ENOG4107QHF type ii secretion system protein e HJX47_RS21595 ENOG4105D7Q type ii secretion system HJX47_RS21600 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HJX47_RS21605 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HJX47_RS21610 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HJX47_RS21615 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HJX47_RS21620 ENOG4105M6F mutator MutT protein HJX47_RS21625 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HJX47_RS21630 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HJX47_RS21635 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJX47_RS21640 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HJX47_RS21645 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HJX47_RS21650 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HJX47_RS21660 ENOG4105DFU Cell wall formation (By similarity) HJX47_RS21665 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HJX47_RS21670 ENOG4105CNI cell division protein FtsW HJX47_RS21680 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HJX47_RS21685 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HJX47_RS21690 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HJX47_RS21695 ENOG4105CJN penicillin-binding protein HJX47_RS21700 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HJX47_RS21705 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HJX47_RS21715 ENOG4107B7Y DNA-binding transcriptional regulator FruR HJX47_RS21720 ENOG4108ZP8 Acetolactate synthase small subunit HJX47_RS21725 ENOG4105C7K acetolactate synthase HJX47_RS21730 ENOG41064T2 transcriptional regulator, lysR family HJX47_RS21745 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HJX47_RS21755 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HJX47_RS21760 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HJX47_RS21775 ENOG4105EMV Major Facilitator HJX47_RS21780 ENOG4105FF2 Type I DHQase HJX47_RS21785 ENOG4105C5Q Transcriptional regulator HJX47_RS21790 ENOG4105DJB Major Facilitator Superfamily HJX47_RS21795 ENOG4105S8Q sugar efflux transporter HJX47_RS21820 ENOG4106SMU thiamine transporter membrane protein HJX47_RS21830 ENOG4108KF1 Membrane HJX47_RS21835 ENOG41063TF transcriptional regulator (AraC HJX47_RS21845 ENOG4105EF1 ribulokinase HJX47_RS21850 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HJX47_RS21855 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HJX47_RS21860 ENOG4105CQ2 DNA polymerase HJX47_RS21865 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HJX47_RS21870 ENOG4105D3G Pseudouridine synthase HJX47_RS21880 ENOG4105D2K citrate carrier protein HJX47_RS21885 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HJX47_RS21890 ENOG4106YYS transcriptional regulatory protein HJX47_RS21895 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HJX47_RS21900 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HJX47_RS21910 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HJX47_RS21915 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HJX47_RS21925 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HJX47_RS21930 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HJX47_RS21935 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJX47_RS21945 ENOG4105M5B (LipO)protein HJX47_RS21950 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HJX47_RS21955 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HJX47_RS21965 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HJX47_RS21970 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HJX47_RS21975 ENOG4105CHY citrate lyase, alpha HJX47_RS21980 ENOG4105CI0 Citrate lyase HJX47_RS21985 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HJX47_RS21990 ENOG4105DUA (citrate (pro-3S)-lyase ligase HJX47_RS21995 ENOG4105D2K citrate carrier protein HJX47_RS22005 ENOG4107QSA Oxaloacetate decarboxylase HJX47_RS22010 ENOG4105D9Q decarboxylase (Beta subunit) HJX47_RS22015 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HJX47_RS22020 ENOG4106YYS transcriptional regulatory protein HJX47_RS22025 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HJX47_RS22030 ENOG4105EXG Transcriptional regulator HJX47_RS22060 ENOG4105BZG amino acid carrier protein HJX47_RS22065 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJX47_RS22070 ENOG4108RIR Molybdenum cofactor biosynthesis protein HJX47_RS22075 ENOG4105CSH Transporter HJX47_RS22080 ENOG4106HK8 GPR1 FUN34 yaaH family protein HJX47_RS22085 ENOG4108QUJ UPF0174 protein YaaW HJX47_RS22090 ENOG4108WTA UPF0412 protein YaaI HJX47_RS22095 ENOG4105CFG Acts as a chaperone (By similarity) HJX47_RS22100 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HJX47_RS22105 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HJX47_RS22110 ENOG41063Z6 transcriptional regulator, lysR family HJX47_RS22130 ENOG4105DTN riboflavin biosynthesis protein ribF HJX47_RS22140 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HJX47_RS22145 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HJX47_RS22150 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HJX47_RS22155 ENOG4105DU0 nucleoside hydrolase HJX47_RS22185 ENOG4105D98 threonine synthase HJX47_RS22190 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HJX47_RS22195 ENOG4105CFH Aspartokinase HJX47_RS22210 ENOG4106FVC RNA methyltransferase HJX47_RS22215 ENOG410759A HJX47_RS22220 ENOG41065U4 response regulator HJX47_RS22225 ENOG4105CT7 inner membrane cred family protein HJX47_RS22230 ENOG4105EB3 Histidine kinase HJX47_RS22235 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJX47_RS22240 ENOG4108RH0 Crea protein HJX47_RS22245 ENOG4105UEI Transcriptional Regulator AraC Family HJX47_RS22250 ENOG4105CVJ phosphoglycerate mutase HJX47_RS22255 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HJX47_RS22260 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HJX47_RS22265 ENOG4107SC1 transglycosylase HJX47_RS22270 ENOG4105C5H ABC transporter HJX47_RS22275 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HJX47_RS22280 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HJX47_RS22285 ENOG4105EAC phosphoserine phosphatase HJX47_RS22290 ENOG41062Z9 Membrane HJX47_RS22295 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HJX47_RS22310 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HJX47_RS22320 ENOG4105D9N nucleoside HJX47_RS22325 ENOG4105EYA deoxyribonuclease HJX47_RS22330 ENOG4108NRW Phospholipase, patatin family HJX47_RS22335 ENOG41075IC Protein of unknown function (DUF1328) HJX47_RS22340 ENOG4105K3G Periplasmic Protein HJX47_RS22345 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HJX47_RS22350 ENOG4105PAD Hydrolase HJX47_RS22355 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HJX47_RS22360 ENOG4108WPU DNA polymerase III subunit psi HJX47_RS22365 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HJX47_RS22385 ENOG4105YBH Protein of unknown function (DUF1435) HJX47_RS22395 ENOG4106TD9 Diguanylate cyclase HJX47_RS22400 ENOG4108819 ferric iron reductase HJX47_RS22405 ENOG4105CK1 PTS System HJX47_RS22410 ENOG4108UIN ybak prolyl-trna synthetase associated region HJX47_RS22415 ENOG4108T94 DNA-binding transcriptional activator BglJ HJX47_RS22420 ENOG4108N8T regulatoR HJX47_RS22430 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HJX47_RS22435 ENOG4105DWK Membrane HJX47_RS22440 ENOG4107XM3 UPF0442 protein HJX47_RS22445 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HJX47_RS22450 ENOG4106CVF DNA replication protein HJX47_RS22455 ENOG4105RI1 glycoprotein receptor HJX47_RS22465 ENOG4105DNE Transposase HJX47_RS22480 ENOG4105F3R pts system mannose fructose sorbose family iid HJX47_RS22485 ENOG4105ETZ PTS System HJX47_RS22490 ENOG4105KPI PTS system sorbose subfamily IIB component HJX47_RS22500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJX47_RS22510 ENOG4105XYF acetyltransferase HJX47_RS22515 ENOG4106KNT transcriptional regulator HJX47_RS22520 ENOG4108RTU Aldolase HJX47_RS22525 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HJX47_RS22555 ENOG4105DG4 malate L-lactate dehydrogenase HJX47_RS22560 ENOG4107QTZ amino acid HJX47_RS22565 ENOG4105CZJ Aldehyde dehydrogenase HJX47_RS22570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HJX47_RS22585 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HJX47_RS22595 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HJX47_RS22600 ENOG4108V8F Transcriptional regulator, MarR family HJX47_RS22610 ENOG4105ERH Fumarylacetoacetate hydrolase HJX47_RS22620 ENOG4105C26 Dehydrogenase HJX47_RS22625 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HJX47_RS22640 ENOG4105CNV Aldolase HJX47_RS22650 ENOG4108NKV transcriptional regulator HJX47_RS22655 ENOG4105EFA 4-hydroxyphenylacetate HJX47_RS22660 ENOG4107UWN reductase HJX47_RS22675 ENOG4105D22 carbon starvation protein HJX47_RS22680 ENOG4105VCD cytoplasmic protein HJX47_RS22685 ENOG4105CKI cobalamin synthesis protein HJX47_RS22695 ENOG4105C26 Dehydrogenase HJX47_RS22700 ENOG4105DNE Transposase HJX47_RS22705 ENOG4106AXJ AraC family transcriptional regulator HJX47_RS22715 ENOG4106BRA Membrane HJX47_RS22720 ENOG41083G8 Multidrug resistance protein MdtM HJX47_RS22730 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HJX47_RS22735 ENOG4105CIZ coA-substrate-specific enzyme activase HJX47_RS22750 ENOG4105EFX secretion protein, HlyD family HJX47_RS22760 ENOG4106DIZ Domain of unknown function (DUF1127) HJX47_RS22765 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJX47_RS22775 ENOG4108F3G Type I restriction-modification system, R subunit HJX47_RS22800 ENOG41064T2 transcriptional regulator, lysR family HJX47_RS22805 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HJX47_RS22810 ENOG4105CNN ABC, transporter HJX47_RS22815 ENOG4105CNN ABC, transporter HJX47_RS22820 ENOG4105C2J ABC transporter HJX47_RS22825 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJX47_RS22835 ENOG4105D0S secretion protein (HlyD HJX47_RS22840 ENOG4105CJ1 ABC, transporter HJX47_RS22845 ENOG4105CMI transporter HJX47_RS22875 ENOG4105EZE Cupin 4 family protein HJX47_RS22890 ENOG4105GR3 Histidine kinase HJX47_RS22895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJX47_RS22900 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJX47_RS22905 ENOG410624V efflux system protein HJX47_RS22910 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HJX47_RS22915 ENOG4108IJF Heavy metal efflux pump, CzcA HJX47_RS22925 ENOG4105QNF Outer membrane lipoprotein HJX47_RS22930 ENOG4108XDN Transcriptional regulator HJX47_RS22940 ENOG4107FW0 short-chain dehydrogenase reductase HJX47_RS22955 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HJX47_RS22975 ENOG4107SEY Conserved Protein HJX47_RS22980 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJX47_RS22990 ENOG4105C93 Xylose Isomerase HJX47_RS22995 ENOG4105CT4 transporter HJX47_RS23000 ENOG4105DSG hydrolase family 43 HJX47_RS23095 ENOG4106H3A restriction HJX47_RS23100 ENOG4108YUH HJX47_RS23115 ENOG4105CVR type I restriction-modification system HJX47_RS23120 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HJX47_RS23135 ENOG41077A9 carbonic anhydrase HJX47_RS23140 ENOG4105CHH sulfate transporter HJX47_RS23145 ENOG4105DQ4 alcohol dehydrogenase HJX47_RS23155 ENOG4105DRS transport system, permease HJX47_RS23160 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HJX47_RS23165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS23175 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HJX47_RS23180 ENOG4105F0H myo-inositol catabolism protein HJX47_RS23190 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HJX47_RS23200 ENOG4105D7K pfkb domain protein HJX47_RS23205 ENOG4105CHC glucokinase (EC 2.7.1.2) HJX47_RS23210 ENOG4105DH8 myo-inositol catabolism HJX47_RS23215 ENOG4105C26 Dehydrogenase HJX47_RS23225 ENOG4105D7A ATP-binding protein HJX47_RS23230 ENOG4108K5H permease YjgP YjgQ family protein HJX47_RS23235 ENOG4108M8S permease YjgP YjgQ family protein HJX47_RS23240 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HJX47_RS23245 ENOG4105MYG DNA polymerase iii, chi subunit HJX47_RS23250 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HJX47_RS23255 ENOG4108MJ3 acetyltransferase HJX47_RS23260 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HJX47_RS23265 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HJX47_RS23275 ENOG4105XEP YhcH YjgK YiaL family protein HJX47_RS23285 ENOG4105CXT aspartate transcarbamylase HJX47_RS23290 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HJX47_RS23295 ENOG4105KME endoribonuclease L-psp HJX47_RS23305 ENOG4105D4X repressor HJX47_RS23310 ENOG4105C5Y PTS System HJX47_RS23315 ENOG4105CG3 alpha amylase, catalytic region HJX47_RS23320 ENOG4105CK1 PTS System HJX47_RS23325 ENOG4105F8D glycoside hydrolase family 4 HJX47_RS23345 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HJX47_RS23350 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HJX47_RS23355 ENOG4105K4U addiction module toxin, RelE StbE family HJX47_RS23365 ENOG4105EMD TRANSCRIPTIONal HJX47_RS23370 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HJX47_RS23385 ENOG41069H0 dihydroorotase EC 3.5.2.3 HJX47_RS23415 ENOG4108XVM Cytochrome b(562) HJX47_RS23420 ENOG4105CMS peptidase U62, modulator of DNA gyrase HJX47_RS23425 ENOG4105N42 UPF0307 protein HJX47_RS23450 ENOG4105DFU Cell wall formation (By similarity) HJX47_RS23455 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HJX47_RS23460 ENOG41062B0 ABC transporter, permease HJX47_RS23465 ENOG4107R9N ABC transporter HJX47_RS23470 ENOG4105C2J ABC transporter HJX47_RS23475 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HJX47_RS23480 ENOG4105F0N pyrophosphate phospho-hydrolase HJX47_RS23495 ENOG4108ZHD aig2 family HJX47_RS23500 ENOG4105MA0 exported protein HJX47_RS23505 ENOG4105CFU surface antigen HJX47_RS23515 ENOG4105C37 (CBS) domain HJX47_RS23525 ENOG41061GZ Protein of unknown function (DUF1107) HJX47_RS23530 ENOG4108UUE Transcriptional regulator HJX47_RS23535 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HJX47_RS23540 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HJX47_RS23545 ENOG4105KVH Transcriptional regulator HJX47_RS23550 ENOG4105ECR NmrA family HJX47_RS23560 ENOG4105DXC membrane HJX47_RS23565 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HJX47_RS23575 ENOG4108V1T peptidylprolyl cis-trans isomerase HJX47_RS23580 ENOG4105FHY Opacity-associated protein A HJX47_RS23585 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HJX47_RS23590 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HJX47_RS23595 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HJX47_RS23600 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HJX47_RS23605 ENOG4105KIT UPF0379 protein yjfY HJX47_RS23630 ENOG4106ETB IIa component HJX47_RS23640 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HJX47_RS23655 ENOG4108MXZ Esterase HJX47_RS23660 ENOG4105WSB biofilm stress and motility protein A HJX47_RS23665 ENOG4105S17 UPF0379 protein yjfN HJX47_RS23670 ENOG4105CSU acyl-Coa dehydrogenase HJX47_RS23675 ENOG4105C2N RNA methyltransferase TrmH family group 3 HJX47_RS23680 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HJX47_RS23685 ENOG4105KPV Transcriptional regulator HJX47_RS23690 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HJX47_RS23705 ENOG4105EPW hflc protein HJX47_RS23710 ENOG4107QJR hflk protein HJX47_RS23715 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HJX47_RS23725 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HJX47_RS23730 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HJX47_RS23740 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HJX47_RS23745 ENOG4105K8N protein family UPF0079, ATPase HJX47_RS23750 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HJX47_RS23755 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HJX47_RS23775 ENOG4106TNF Periplasmic binding protein HJX47_RS23780 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HJX47_RS23785 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HJX47_RS23790 ENOG4105DJ4 phosphatidylserine decarboxylase HJX47_RS23795 ENOG4105EGS Mechanosensitive ion channel HJX47_RS23800 ENOG4107SC7 Inner membrane transporter yjeM HJX47_RS23805 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HJX47_RS23810 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HJX47_RS23815 ENOG4105E33 succinate dehydrogenase HJX47_RS23825 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HJX47_RS23835 ENOG4105KPY Small multidrug resistance protein HJX47_RS23840 ENOG4106BSU Entericidin B HJX47_RS23850 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HJX47_RS23855 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HJX47_RS23875 ENOG4105CW0 outer membrane usher protein HJX47_RS23890 ENOG4108MBX Secretion Protein HJX47_RS23895 ENOG4108JJA ABC, transporter HJX47_RS23905 ENOG4108ZVF (LipO)protein HJX47_RS23910 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HJX47_RS23920 ENOG4105DVH amino acid HJX47_RS23925 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HJX47_RS23930 ENOG4108IJ0 Aspartate ammonia-lyase HJX47_RS23935 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HJX47_RS23945 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HJX47_RS23950 ENOG4108SIC Transcriptional regulator HJX47_RS24000 ENOG4108TUY outer membrane protein PgaA HJX47_RS24005 ENOG4107BJW polysaccharide deacetylase HJX47_RS24010 ENOG4105CND Glycosyl transferase, family 2 HJX47_RS24030 ENOG4108ZCF integral membrane protein HJX47_RS24040 ENOG4105DVC DnaJ domain protein HJX47_RS24070 ENOG4105CT4 transporter HJX47_RS24075 ENOG4105F8D glycoside hydrolase family 4 HJX47_RS24080 ENOG4108K2B transcriptional regulator HJX47_RS24085 ENOG4105CSH Transporter HJX47_RS24090 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HJX47_RS24095 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HJX47_RS24100 ENOG4107RJJ Transcriptional regulator HJX47_RS24105 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HJX47_RS24110 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HJX47_RS24115 ENOG4105EKV Phosphonate metabolism protein HJX47_RS24120 ENOG4105FT8 Phosphonate metabolism HJX47_RS24125 ENOG4105ENV phosphonate C-P lyase system protein PhnK HJX47_RS24130 ENOG4105HRV phosphonate c-p lyase system protein phnl HJX47_RS24135 ENOG4105FD8 phosphonate metabolism protein PhnM HJX47_RS24140 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HJX47_RS24145 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HJX47_RS24155 ENOG4105BZU Histidine kinase HJX47_RS24160 ENOG4105C2J ABC transporter HJX47_RS24165 ENOG4105CNN ABC, transporter HJX47_RS24170 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJX47_RS24210 ENOG41082ND Uncharacterized protein yjcO HJX47_RS24215 ENOG4105CK2 sodium dicarboxylate symporter HJX47_RS24225 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HJX47_RS24230 ENOG41062QD Membrane HJX47_RS24235 ENOG4107QN1 sodium solute HJX47_RS24250 ENOG4105CW0 outer membrane usher protein HJX47_RS24255 ENOG4108VCD Chaperone HJX47_RS24260 ENOG4105MX3 Fimbrial HJX47_RS24270 ENOG41067MG lrgb family HJX47_RS24280 ENOG4105CMU LysR family (Transcriptional regulator HJX47_RS24285 ENOG4105EEQ Na H antiporter HJX47_RS24290 ENOG4105C7N Xanthine uracil vitamin C permease HJX47_RS24295 ENOG4108K3A Glutathione S-transferase HJX47_RS24300 ENOG4108Z4X TRANSCRIPTIONal HJX47_RS24305 ENOG4108W3Q Transcriptional regulator HJX47_RS24310 ENOG4108M8H domain protein HJX47_RS24315 ENOG4105PMV Membrane HJX47_RS24340 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HJX47_RS24345 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS24350 ENOG4105ECY inositol monophosphatase HJX47_RS24365 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJX47_RS24385 ENOG4108DMH HTH_ARAC HJX47_RS24390 ENOG4107RNH Outer membrane receptor FepA HJX47_RS24395 ENOG4108BUD transposase HJX47_RS24430 ENOG4105E4C Lytic transglycosylase catalytic HJX47_RS24435 ENOG4108UUM single-stranded DNA-binding protein HJX47_RS24440 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HJX47_RS24445 ENOG4105MSB protein, conserved in bacteria HJX47_RS24450 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HJX47_RS24460 ENOG4105CGF Aromatic amino acid aminotransferase HJX47_RS24465 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HJX47_RS24470 ENOG4105CDU Replicative dna helicase HJX47_RS24475 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HJX47_RS24480 ENOG4105P4Z Phage shock protein G HJX47_RS24485 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HJX47_RS24495 ENOG4105MYN Zinc uptake regulation protein HJX47_RS24500 ENOG4105VDW Csbd family HJX47_RS24510 ENOG4107R73 Mate efflux family protein HJX47_RS24515 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HJX47_RS24520 ENOG41080IJ Diacylglycerol kinase HJX47_RS24525 ENOG4105E55 glycerol-3-phosphate acyltransferase HJX47_RS24530 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HJX47_RS24535 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HJX47_RS24540 ENOG4107W52 maltose operon periplasmic protein HJX47_RS24545 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJX47_RS24550 ENOG4108IJ9 (ABC) transporter HJX47_RS24555 ENOG4107FKK extracellular solute-binding protein family 1 HJX47_RS24560 ENOG4105D56 permease protein HJX47_RS24565 ENOG4105EG2 ABC transporter, permease HJX47_RS24570 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HJX47_RS24575 ENOG4105CEM UPF0597 protein HJX47_RS24590 ENOG4105KME endoribonuclease L-psp HJX47_RS24600 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HJX47_RS24605 ENOG4107QP8 phosphohexose isomerase HJX47_RS24610 ENOG4105CFH Aspartokinase HJX47_RS24615 ENOG4105C09 Bile acid HJX47_RS24620 ENOG4108ZR5 Conserved Protein HJX47_RS24625 ENOG4105FE9 pseudouridine synthase HJX47_RS24630 ENOG4105DKT Transcriptional regulator HJX47_RS24635 ENOG4105CHR reductase HJX47_RS24640 ENOG4108XCU pts system HJX47_RS24645 ENOG4105KPI PTS system sorbose subfamily IIB component HJX47_RS24650 ENOG4105ETZ PTS System HJX47_RS24655 ENOG4105F3R pts system mannose fructose sorbose family iid HJX47_RS24660 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HJX47_RS24665 ENOG4105F9E Shikimate 5-dehydrogenase HJX47_RS24670 ENOG4105EAM Na Pi-cotransporter HJX47_RS24675 ENOG4105C3R Methionine synthase HJX47_RS24680 ENOG41069M3 Transcriptional regulator HJX47_RS24685 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HJX47_RS24690 ENOG4108I9X Isocitrate lyase HJX47_RS24695 ENOG4107QP3 malate synthase g HJX47_RS24700 ENOG4105CVG Homoserine O-transsuccinylase HJX47_RS24705 ENOG4105K5X acetyltransferase HJX47_RS24730 ENOG4105DC1 bifunctional purine biosynthesis protein purh HJX47_RS24735 ENOG4105C12 Phosphoribosylglycinamide synthetase HJX47_RS24745 ENOG4105BZU Histidine kinase HJX47_RS24750 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HJX47_RS24755 ENOG4108T8B Protein of unknown function (DUF1481) HJX47_RS24760 ENOG4105K70 DNA-binding protein HJX47_RS24765 ENOG4105R2J Conserved Protein HJX47_RS24770 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HJX47_RS24775 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HJX47_RS24780 ENOG4105E09 nadh pyrophosphatase HJX47_RS24785 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HJX47_RS24790 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HJX47_RS24795 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HJX47_RS24800 ENOG4105D06 uba thif-type nad fad binding protein HJX47_RS24805 ENOG4105WHD thiamine biosynthesis protein ThiS HJX47_RS24810 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HJX47_RS24815 ENOG4105D41 biosynthesis protein thiH HJX47_RS24820 ENOG4106TD9 Diguanylate cyclase HJX47_RS24830 ENOG4105VCP PTS System HJX47_RS24835 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HJX47_RS24840 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJX47_RS24845 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJX47_RS24850 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HJX47_RS24855 ENOG4108VZM 50s ribosomal protein L10 HJX47_RS24860 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HJX47_RS24865 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HJX47_RS24870 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HJX47_RS24875 ENOG4105PM1 preprotein translocase subunit SecE HJX47_RS24880 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HJX47_RS24905 ENOG4105CS9 pantothenic acid kinase HJX47_RS24910 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HJX47_RS24945 ENOG4108RR8 protoporphyrinogen oxidase HJX47_RS24950 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HJX47_RS24955 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HJX47_RS24960 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HJX47_RS24965 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) HJX47_RS24970 ENOG4105CHU acetyl-coa acetyltransferase HJX47_RS24975 ENOG4107QK7 reductase HJX47_RS24980 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJX47_RS24990 ENOG4105MDZ Transcriptional activator rfaH HJX47_RS25000 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HJX47_RS25005 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HJX47_RS25010 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HJX47_RS25015 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HJX47_RS25020 ENOG4105JC1 sterol-binding domain protein HJX47_RS25025 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HJX47_RS25030 ENOG4105CGY Dna recombination protein HJX47_RS25035 ENOG4107SXA Phosphorylase HJX47_RS25040 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HJX47_RS25045 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HJX47_RS25050 ENOG4105DZ2 Transcriptional regulator HJX47_RS25055 ENOG4105EMK carboxylate amino acid amine transporter HJX47_RS25060 ENOG4105DQF Hydrolase HJX47_RS25065 ENOG4108EUD Lysophospholipase HJX47_RS25070 ENOG410829K Lysine exporter protein (Lyse ygga) HJX47_RS25080 ENOG4105CCF Lysine exporter protein (Lyse ygga) HJX47_RS25085 ENOG4105C9U ATP-dependent DNA helicase RecQ HJX47_RS25090 ENOG4105HDD phospholipase HJX47_RS25095 ENOG4108VUY thioesterase Superfamily protein HJX47_RS25100 ENOG4105FR1 rard protein HJX47_RS25105 ENOG4107QUT magnesium and cobalt transport protein CorA HJX47_RS25110 ENOG4105C4R Atp-dependent dna helicase HJX47_RS25115 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HJX47_RS25120 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJX47_RS25125 ENOG4105CT0 Protein of unknown function, DUF484 HJX47_RS25135 ENOG4105S7Z (LipO)protein HJX47_RS25140 ENOG4105XQ6 frataxin-like protein HJX47_RS25145 ENOG4107T0K Adenylate cyclase HJX47_RS25150 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HJX47_RS25155 ENOG41076E6 Uroporphyrinogen-III Synthase HJX47_RS25160 ENOG4105ECF c-methyltransferase HJX47_RS25165 ENOG410601J HemY protein HJX47_RS25195 ENOG4105C85 amino acid HJX47_RS25200 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HJX47_RS25205 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HJX47_RS25210 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HJX47_RS25215 ENOG4105EGZ biosynthesis protein HJX47_RS25220 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HJX47_RS25225 ENOG4108WJ1 acetyltransferase HJX47_RS25230 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HJX47_RS25235 ENOG4105C1B dTDP-glucose 4-6-dehydratase HJX47_RS25240 ENOG4107QQG Dehydrogenase HJX47_RS25245 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HJX47_RS25250 ENOG4105SFE lipopolysaccharide biosynthesis protein HJX47_RS25255 ENOG4105ESV Glycosyl transferase, family 4 HJX47_RS25260 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HJX47_RS25270 ENOG4105C1J atp-dependent rna helicase HJX47_RS25275 ENOG4105C9X ppx gppa phosphatase HJX47_RS25290 ENOG4108UQV Membrane HJX47_RS25295 ENOG4105C4R Atp-dependent dna helicase HJX47_RS25300 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HJX47_RS25305 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HJX47_RS25310 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HJX47_RS25315 ENOG4105EMY transcriptional regulator HJX47_RS25320 ENOG4105C7B Threonine dehydratase HJX47_RS25325 ENOG4105C01 Dihydroxy-acid dehydratase HJX47_RS25330 ENOG4105CM2 brancheD-chain amino acid aminotransferase HJX47_RS25335 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HJX47_RS25350 ENOG4105C0P Mg chelatase subunit ChlI HJX47_RS25355 ENOG4108WFC UPF0438 protein yifE HJX47_RS25410 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HJX47_RS25415 ENOG4108Y73 Membrane HJX47_RS25420 ENOG4105EJ2 Transcriptional regulator HJX47_RS25425 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HJX47_RS25430 ENOG4105C5Q Transcriptional regulator HJX47_RS25435 ENOG4105CH7 arginosuccinase HJX47_RS25440 ENOG4105CAS nag kinase HJX47_RS25445 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HJX47_RS25460 ENOG4108MEK Metal-binding protein YodA HJX47_RS25465 ENOG4106R3P AraC family transcriptional regulator HJX47_RS25470 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJX47_RS25475 ENOG4105DCT glycerol dehydrogenase HJX47_RS25480 ENOG4108Q5Y Membrane HJX47_RS25485 ENOG4105SYT Methylenetetrahydrofolate reductase HJX47_RS25490 ENOG4105CN8 Transcriptional regulator HJX47_RS25495 ENOG4108Z8I decarboxylase HJX47_RS25500 ENOG4105CGH 5'-nucleotidase HJX47_RS25510 ENOG4105CFH Aspartokinase HJX47_RS25515 ENOG4105C28 cystathionine HJX47_RS25520 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HJX47_RS25525 ENOG4105VFB Binds the 23S rRNA (By similarity) HJX47_RS25530 ENOG4105C25 Primosomal protein n' HJX47_RS25535 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS25540 ENOG41063M6 Cell Division Protein HJX47_RS25545 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HJX47_RS25555 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HJX47_RS25560 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HJX47_RS25565 ENOG4105CTQ phosphohexokinase HJX47_RS25570 ENOG41076HS cation diffusion facilitator family transporter HJX47_RS25575 ENOG4105FMW periplasmic HJX47_RS25580 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJX47_RS25585 ENOG4105E0F Histidine kinase HJX47_RS25590 ENOG4108RPX mosc domain containing protein HJX47_RS25595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJX47_RS25600 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HJX47_RS25605 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HJX47_RS25610 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HJX47_RS25615 ENOG4105DET Rhamnulokinase HJX47_RS25620 ENOG4105DKG l-rhamnose isomerase HJX47_RS25625 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HJX47_RS25630 ENOG4105D4B ABC, transporter HJX47_RS25635 ENOG4105C2J ABC transporter HJX47_RS25640 ENOG4105CNN ABC, transporter HJX47_RS25645 ENOG4105CNN ABC, transporter HJX47_RS25650 ENOG4105C0A alcohol dehydrogenase HJX47_RS25660 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJX47_RS25705 ENOG4105D2N Aldolase HJX47_RS25720 ENOG4105CTQ phosphohexokinase HJX47_RS25730 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HJX47_RS25740 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HJX47_RS25745 ENOG4108MG3 formate dehydrogenase HJX47_RS25750 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HJX47_RS25760 ENOG41068KX affects formate dehydrogenase-N HJX47_RS25770 ENOG4105SUU thioesterase domain HJX47_RS25775 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HJX47_RS25780 ENOG4107S2Z UPF0761 membrane protein HJX47_RS25785 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HJX47_RS25790 ENOG4105CI3 gtp-binding protein typa HJX47_RS25795 ENOG4105C5F glutamine synthetase HJX47_RS25800 ENOG4105CUX Signal transduction histidine kinase HJX47_RS25805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJX47_RS25810 ENOG4106FIY HJX47_RS25815 ENOG4105D4P Coproporphyrinogen iii oxidase HJX47_RS25820 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HJX47_RS25825 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HJX47_RS25830 ENOG4105C2M dna polymerase I HJX47_RS25835 ENOG4106HNH Acyl-transferase HJX47_RS25840 ENOG4108Z33 Thiol disulfide Interchange Protein HJX47_RS25845 ENOG4105E27 serine threonine protein kinase HJX47_RS25850 ENOG4105PC1 Conserved Protein HJX47_RS25855 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HJX47_RS25860 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HJX47_RS25885 ENOG4107EJG GntR family transcriptional regulator HJX47_RS25890 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJX47_RS25895 ENOG4105ETE Transcriptional regulator (LacI family HJX47_RS25900 ENOG4108RVA ribokinase HJX47_RS25905 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJX47_RS25910 ENOG4105CNN ABC, transporter HJX47_RS25915 ENOG4105C2J ABC transporter HJX47_RS25925 ENOG4105DFH Transport of potassium into the cell (By similarity) HJX47_RS25940 ENOG4105CU9 asparagine synthetase A HJX47_RS25945 ENOG4108VVK transcriptional Regulator, AsnC HJX47_RS25950 ENOG4105QTB Flavodoxin HJX47_RS25955 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HJX47_RS25960 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HJX47_RS25965 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HJX47_RS25985 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HJX47_RS25990 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HJX47_RS25995 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HJX47_RS26000 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HJX47_RS26005 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HJX47_RS26025 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HJX47_RS26030 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HJX47_RS26035 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HJX47_RS26040 ENOG4105C8U phosphate abc transporter HJX47_RS26045 ENOG4105E2Z phosphate ABC transporter (Permease HJX47_RS26050 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HJX47_RS26070 ENOG4105DYC esterase HJX47_RS26075 ENOG4107VKM 6-phosphogluconolactonase HJX47_RS26080 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HJX47_RS26090 ENOG4105C7N Xanthine uracil vitamin C permease HJX47_RS26095 ENOG4108YYH Nadph-dependent fmn reductase HJX47_RS26100 ENOG4105E8Q phosphopantetheinyl transferase HJX47_RS26110 ENOG4105C2C drug resistance transporter, Bcr CflA HJX47_RS26165 ENOG4105DHP deoxycytidine triphosphate deaminase HJX47_RS26185 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HJX47_RS26190 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HJX47_RS26195 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HJX47_RS26205 ENOG4105VG0 50S ribosomal protein l34 HJX47_RS26220 ENOG410620I Diguanylate cyclase HJX47_RS26240 ENOG4108M8H domain protein HJX47_RS26250 ENOG4105C94 Transporter HJX47_RS26295 ENOG410624V efflux system protein HJX47_RS26325 ENOG4105DR5 peptidase HJX47_RS26335 ENOG4105E3B Multicopper oxidase HJX47_RS26340 ENOG4105VR0 copper resistance HJX47_RS26345 ENOG4105JDN Copper resistance protein HJX47_RS26350 ENOG4108PG2 copper resistance HJX47_RS26355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJX47_RS26360 ENOG4105GR3 Histidine kinase HJX47_RS26380 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJX47_RS26395 ENOG4105CAU Arsenical resistance protein, ArsH HJX47_RS26465 ENOG4105KF5 hemolysin expression-modulating protein HJX47_RS26490 ENOG4108RAV Conserved protein HJX47_RS26500 ENOG4108BUD transposase HJX47_RS26535 ENOG4108BUD transposase HJX47_RS26545 ENOG4105EQR Transposase IS116 IS110 IS902 HJX47_RS26560 ENOG4108R0M Aminoglycoside HJX47_RS26615 ENOG4108BUD transposase HJX47_RS26660 ENOG4108KTG Membrane protein, drug metabolite transporter HJX47_RS26685 ENOG4108BUD transposase HJX47_RS26705 ENOG4108BUD transposase HJX47_RS26715 ENOG4105I1F Resistance protein HJX47_RS26725 ENOG4108BUD transposase HJX47_RS26745 ENOG4108BUD transposase HJX47_RS26770 ENOG4108BUD transposase HJX47_RS26780 ENOG4108BUD transposase HJX47_RS26815 ENOG4108BUD transposase HJX47_RS26825 ENOG4106CQM replication HJX47_RS26835 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HJX47_RS26865 ENOG4107CBI conjugal transfer fertility inhibition protein HJX47_RS27100 ENOG4108Z3N Transcriptional regulator HJX47_RS27160 ENOG41074AV Hok/gef family HJX47_RS27205 ENOG4105FEQ ParB domain protein nuclease HJX47_RS27280 ENOG4105EKQ RNA-directed DNA polymerase