locus-tag	class	description
C2M21_RS00020	COG0187	DNA topoisomerase II activity
C2M21_RS00025	COG0561	phosphatase activity
C2M21_RS00040	COG2186	Transcriptional regulator
C2M21_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
C2M21_RS00050	COG0800	Aldolase
C2M21_RS00060	COG2271	Major facilitator Superfamily
C2M21_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
C2M21_RS00070	COG5645	(Lipo)protein
C2M21_RS00085	COG3645	SOS response
C2M21_RS00095	COG2188	Transcriptional regulator
C2M21_RS00110	COG2149	membrane
C2M21_RS00130	COG2610	gluconate transmembrane transporter activity
C2M21_RS00135	COG0583	DNA-binding transcription factor activity
C2M21_RS00140	COG2814	Major facilitator Superfamily
C2M21_RS00165	COG0028	Belongs to the TPP enzyme family
C2M21_RS00170	COG0440	acetolactate synthase activity
C2M21_RS00175	COG2197	response regulator
C2M21_RS00185	COG2271	Major facilitator Superfamily
C2M21_RS00235	COG2188	Transcriptional regulator
C2M21_RS00260	COG4580	involved in the transport of maltose and maltodextrins
C2M21_RS00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2M21_RS00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS00280	COG1609	Transcriptional regulator
C2M21_RS00290	COG3384	dioxygenase
C2M21_RS00295	COG0583	DNA-binding transcription factor activity
C2M21_RS00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2M21_RS00305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2M21_RS00310	COG2828	Protein conserved in bacteria
C2M21_RS00325	COG0697	spore germination
C2M21_RS00330	COG1263	PTS System
C2M21_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2M21_RS00340	COG2814	Major facilitator Superfamily
C2M21_RS00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2M21_RS00385	COG0583	DNA-binding transcription factor activity
C2M21_RS00410	COG1464	Belongs to the NlpA lipoprotein family
C2M21_RS00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2M21_RS00435	COG1064	alcohol dehydrogenase
C2M21_RS00470	COG2211	Major facilitator Superfamily
C2M21_RS00475	COG1501	Belongs to the glycosyl hydrolase 31 family
C2M21_RS00485	COG1486	melibiose metabolic process
C2M21_RS00490	COG1263	PTS System
C2M21_RS00490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2M21_RS00495	COG2982	Protein involved in outer membrane biogenesis
C2M21_RS00500	COG2233	PERMEase
C2M21_RS00505	COG0786	glutamate:sodium symporter activity
C2M21_RS00525	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2M21_RS00550	COG3152	Membrane
C2M21_RS00560	COG1494	fructose-1,6-bisphosphatase
C2M21_RS00565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2M21_RS00570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2M21_RS00575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2M21_RS00595	COG2860	membrane
C2M21_RS00605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2M21_RS00605	COG2169	Transcriptional regulator
C2M21_RS00610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2M21_RS00615	COG1561	YicC-like family, N-terminal region
C2M21_RS00635	COG1131	(ABC) transporter
C2M21_RS00640	COG0842	Transport permease protein
C2M21_RS00665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2M21_RS00700	COG1519	Transferase
C2M21_RS00705	COG1216	Glycosyl transferase, family 2
C2M21_RS00710	COG0438	transferase activity, transferring glycosyl groups
C2M21_RS00720	COG0859	PFAM glycosyl transferase family 9
C2M21_RS00730	COG1216	Glycosyl transferase, family 2
C2M21_RS00730	COG1442	glycosyl transferase family 8
C2M21_RS00735	COG3307	-O-antigen
C2M21_RS00740	COG0438	transferase activity, transferring glycosyl groups
C2M21_RS00745	COG0859	PFAM glycosyl transferase family 9
C2M21_RS00760	COG0156	8-amino-7-oxononanoate synthase activity
C2M21_RS00770	COG0463	Glycosyl transferase, family 2
C2M21_RS00775	COG2861	carbohydrate metabolic process
C2M21_RS00780	COG4942	peptidase
C2M21_RS00790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2M21_RS00795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2M21_RS00815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2M21_RS00825	COG2186	Transcriptional regulator
C2M21_RS00845	COG3722	fumarate hydratase activity
C2M21_RS00860	COG0625	glutathione transferase activity
C2M21_RS00870	COG3276	selenocysteine insertion sequence binding
C2M21_RS00875	COG1414	Transcriptional regulator
C2M21_RS00880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2M21_RS00885	COG3977	Valine--pyruvate aminotransferase
C2M21_RS00890	COG0366	Alpha amylase catalytic
C2M21_RS00895	COG2992	FlgJ-related protein
C2M21_RS00900	COG1609	Transcriptional regulator
C2M21_RS00900	COG2207	Transcriptional regulator
C2M21_RS00905	COG4214	carbohydrate transport
C2M21_RS00915	COG4213	ABC transporter substrate-binding protein
C2M21_RS00935	COG4682	membrane
C2M21_RS00940	COG4682	membrane
C2M21_RS00945	COG3274	enterobacterial common antigen metabolic process
C2M21_RS00975	COG0488	(ABC) transporter
C2M21_RS00980	COG1278	Cold shock
C2M21_RS00985	COG2944	sequence-specific DNA binding
C2M21_RS00990	COG2814	Major facilitator Superfamily
C2M21_RS01015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2M21_RS01025	COG1609	Transcriptional regulator
C2M21_RS01030	COG2885	chlorophyll binding
C2M21_RS01035	COG0243	molybdopterin cofactor binding
C2M21_RS01040	COG0456	acetyltransferase
C2M21_RS01045	COG2818	Glycosylase
C2M21_RS01050	COG5571	outer membrane autotransporter
C2M21_RS01055	COG2223	nitrite transmembrane transporter activity
C2M21_RS01085	COG0747	negative chemotaxis
C2M21_RS01090	COG0601	transmembrane transport
C2M21_RS01095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2M21_RS01100	COG0444	Belongs to the ABC transporter superfamily
C2M21_RS01105	COG4608	Belongs to the ABC transporter superfamily
C2M21_RS01120	COG2894	cell division
C2M21_RS01130	COG1215	transferase activity, transferring glycosyl groups
C2M21_RS01135	COG0457	Tetratricopeptide repeat
C2M21_RS01150	COG2194	sulfuric ester hydrolase activity
C2M21_RS01180	COG1215	transferase activity, transferring glycosyl groups
C2M21_RS01185	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2M21_RS01190	COG0457	Tetratricopeptide repeat
C2M21_RS01190	COG3118	belongs to the thioredoxin family
C2M21_RS01195	COG2200	EAL domain
C2M21_RS01195	COG2199	diguanylate cyclase activity
C2M21_RS01205	COG0612	Peptidase, M16
C2M21_RS01220	COG2982	Protein involved in outer membrane biogenesis
C2M21_RS01225	COG0477	Major facilitator Superfamily
C2M21_RS01230	COG1295	ribonuclease BN
C2M21_RS01235	COG0583	DNA-binding transcription factor activity
C2M21_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS01245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2M21_RS01255	COG1454	alcohol dehydrogenase
C2M21_RS01265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2M21_RS01270	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2M21_RS01275	COG0671	phosphoesterase, PA-phosphatase related
C2M21_RS01295	COG0589	response to stress
C2M21_RS01305	COG0306	phosphate transporter
C2M21_RS01310	COG2081	HI0933 family
C2M21_RS01315	COG2239	Acts as a magnesium transporter
C2M21_RS01325	COG1124	(ABC) transporter
C2M21_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2M21_RS01340	COG0601	transmembrane transport
C2M21_RS01345	COG0747	negative chemotaxis
C2M21_RS01360	COG3479	Phenolic acid decarboxylase
C2M21_RS01400	COG0628	permease
C2M21_RS01405	COG0477	Major facilitator Superfamily
C2M21_RS01415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2M21_RS01430	COG3714	YhhN family
C2M21_RS01440	COG3776	membrane
C2M21_RS01445	COG0742	ribosomal rna small subunit methyltransferase
C2M21_RS01450	COG0552	protein localization to endoplasmic reticulum
C2M21_RS01455	COG2884	Cell division ATP-binding protein ftsE
C2M21_RS01460	COG2177	Part of the ABC transporter FtsEX involved in
C2M21_RS01475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2M21_RS01485	COG0683	leucine binding
C2M21_RS01500	COG0683	leucine binding
C2M21_RS01505	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS01555	COG0584	glycerophosphoryl diester phosphodiesterase
C2M21_RS01565	COG0405	Gamma-glutamyltransferase
C2M21_RS01570	COG1247	-acetyltransferase
C2M21_RS01580	COG0673	inositol 2-dehydrogenase activity
C2M21_RS01585	COG1741	Belongs to the pirin family
C2M21_RS01590	COG1609	Transcriptional regulator
C2M21_RS01595	COG3265	gluconokinase activity
C2M21_RS01600	COG2610	gluconate transmembrane transporter activity
C2M21_RS01610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2M21_RS01635	COG0058	SHG alpha-glucan phosphorylase activity
C2M21_RS01640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2M21_RS01655	COG1349	DNA-binding transcription factor activity
C2M21_RS01670	COG0058	SHG alpha-glucan phosphorylase activity
C2M21_RS01675	COG1640	4-alpha-glucanotransferase
C2M21_RS01680	COG2610	gluconate transmembrane transporter activity
C2M21_RS01690	COG1040	competence protein
C2M21_RS01715	COG1918	ferrous iron import across plasma membrane
C2M21_RS01720	COG2183	response to ionizing radiation
C2M21_RS01725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2M21_RS01750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2M21_RS01755	COG1011	Hydrolase
C2M21_RS01765	COG0494	nUDIX hydrolase
C2M21_RS01770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2M21_RS01795	COG4796	Type ii and iii secretion system protein
C2M21_RS01815	COG3266	domain, Protein
C2M21_RS01820	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2M21_RS01825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2M21_RS01850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2M21_RS01855	COG0402	S-adenosylhomocysteine deaminase activity
C2M21_RS01860	COG0738	Major facilitator superfamily
C2M21_RS01885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2M21_RS01890	COG1289	transmembrane transporter activity
C2M21_RS01900	COG1765	OsmC-like protein
C2M21_RS01905	COG3954	Phosphoribulokinase
C2M21_RS01915	COG0429	hydrolase of the alpha beta-hydrolase fold
C2M21_RS01925	COG0488	(ABC) transporter
C2M21_RS01940	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2M21_RS01945	COG1047	Peptidyl-prolyl cis-trans
C2M21_RS01955	COG0545	Peptidyl-prolyl cis-trans isomerase
C2M21_RS01960	COG2964	Protein conserved in bacteria
C2M21_RS02015	COG0051	transcription antitermination factor activity, RNA binding
C2M21_RS02040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2M21_RS02055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2M21_RS02120	COG0201	protein transport
C2M21_RS02145	COG0202	RNA polymerase activity
C2M21_RS02160	COG0789	Transcriptional regulator
C2M21_RS02165	COG3036	rescue of stalled ribosome
C2M21_RS02195	COG0758	DNA mediated transformation
C2M21_RS02205	COG0551	DNA topoisomerase type I activity
C2M21_RS02225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2M21_RS02260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2M21_RS02265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS02270	COG1309	transcriptional regulator
C2M21_RS02295	COG4145	pantothenate transmembrane transporter activity
C2M21_RS02300	COG3924	membrane
C2M21_RS02305	COG0439	Biotin carboxylase
C2M21_RS02310	COG0511	ligase activity, forming carbon-carbon bonds
C2M21_RS02335	COG2199	diguanylate cyclase activity
C2M21_RS02335	COG2200	EAL domain
C2M21_RS02340	COG1077	Cell shape determining protein MreB Mrl
C2M21_RS02345	COG1792	Involved in formation and maintenance of cell shape
C2M21_RS02350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2M21_RS02360	COG1530	ribonuclease E activity
C2M21_RS02365	COG3164	Protein of unknown function
C2M21_RS02370	COG0312	modulator of DNA gyrase
C2M21_RS02375	COG0583	DNA-binding transcription factor activity
C2M21_RS02390	COG1289	transmembrane transporter activity
C2M21_RS02395	COG2732	(Barnase) inhibitor
C2M21_RS02420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2M21_RS02425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2M21_RS02430	COG3105	Protein conserved in bacteria
C2M21_RS02435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2M21_RS02455	COG0625	glutathione transferase activity
C2M21_RS02460	COG2969	positive regulation of protein catabolic process
C2M21_RS02470	COG0493	'glutamate synthase
C2M21_RS02475	COG0069	glutamate synthase activity
C2M21_RS02475	COG0070	glutamate synthase
C2M21_RS02475	COG0067	glutamate synthase
C2M21_RS02480	COG1242	4 iron, 4 sulfur cluster binding
C2M21_RS02485	COG2271	Major facilitator Superfamily
C2M21_RS02490	COG1063	alcohol dehydrogenase
C2M21_RS02495	COG1312	Catalyzes the dehydration of D-mannonate
C2M21_RS02500	COG0784	Response regulator, receiver
C2M21_RS02500	COG2198	Histidine kinase
C2M21_RS02500	COG5002	protein histidine kinase activity
C2M21_RS02505	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2M21_RS02510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2M21_RS02515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS02525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS02530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2M21_RS02535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2M21_RS02540	COG1137	ATPase activity
C2M21_RS02545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2M21_RS02550	COG3117	lipopolysaccharide transmembrane transporter activity
C2M21_RS02555	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2M21_RS02565	COG0530	calcium, potassium:sodium antiporter activity
C2M21_RS02575	COG1127	ABC transporter
C2M21_RS02580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2M21_RS02585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2M21_RS02590	COG2854	intermembrane phospholipid transfer
C2M21_RS02595	COG3113	response to antibiotic
C2M21_RS02600	COG5007	Belongs to the BolA IbaG family
C2M21_RS02610	COG3423	Transcriptional regulator
C2M21_RS02615	COG0142	geranyltranstransferase activity
C2M21_RS02630	COG0697	spore germination
C2M21_RS02640	COG2027	D-alanyl-D-alanine carboxypeptidase
C2M21_RS02650	COG1534	Rna-binding protein
C2M21_RS02660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2M21_RS02665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2M21_RS02675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2M21_RS02715	COG0195	Participates in both transcription termination and antitermination
C2M21_RS02765	COG0814	amino acid
C2M21_RS02770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2M21_RS02775	COG0826	peptidase U32
C2M21_RS02780	COG0826	peptidase U32
C2M21_RS02785	COG3154	lipid carrier protein
C2M21_RS02790	COG3153	acetyltransferase
C2M21_RS02805	COG0693	protein deglycase activity
C2M21_RS02810	COG0702	epimerase
C2M21_RS02815	COG0701	Predicted permease
C2M21_RS02820	COG2823	Periplasmic or secreted lipoprotein
C2M21_RS02840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2M21_RS02845	COG2721	sulfolactate sulfo-lyase activity
C2M21_RS02855	COG2271	Major facilitator Superfamily
C2M21_RS02865	COG2084	Dehydrogenase
C2M21_RS02870	COG1929	Belongs to the glycerate kinase type-1 family
C2M21_RS02890	COG1741	Belongs to the pirin family
C2M21_RS02895	COG0583	DNA-binding transcription factor activity
C2M21_RS02900	COG3152	Membrane
C2M21_RS02905	COG0435	Glutathione S-transferase
C2M21_RS02910	COG2259	Doxx family
C2M21_RS02920	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2M21_RS02925	COG4575	ribosome binding
C2M21_RS02930	COG1422	Protein of unknown function (DUF1090)
C2M21_RS02940	COG0586	Pfam SNARE associated Golgi protein
C2M21_RS02945	COG2186	Transcriptional regulator
C2M21_RS02950	COG2271	Major facilitator Superfamily
C2M21_RS02960	COG2721	sulfolactate sulfo-lyase activity
C2M21_RS02975	COG0861	Integral membrane protein TerC family
C2M21_RS02980	COG0673	inositol 2-dehydrogenase activity
C2M21_RS02985	COG1451	nucleotide metabolic process
C2M21_RS03005	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2M21_RS03005	COG1902	pentaerythritol trinitrate reductase activity
C2M21_RS03055	COG1695	Transcriptional regulator
C2M21_RS03060	COG2375	cellular response to nickel ion
C2M21_RS03075	COG1461	Dihydroxyacetone kinase
C2M21_RS03080	COG2376	Dihydroxyacetone kinase
C2M21_RS03155	COG3247	response to pH
C2M21_RS03165	COG2205	protein histidine kinase activity
C2M21_RS03165	COG0784	Response regulator, receiver
C2M21_RS03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS03165	COG2198	Histidine kinase
C2M21_RS03170	COG2197	response regulator
C2M21_RS03185	COG4974	Belongs to the 'phage' integrase family
C2M21_RS03250	COG4695	Portal protein
C2M21_RS03410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2M21_RS03415	COG0358	DNA primase activity
C2M21_RS03420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2M21_RS03480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2M21_RS03495	COG4991	sh3 domain protein
C2M21_RS03500	COG3025	triphosphatase activity
C2M21_RS03520	COG2960	long-chain fatty acid transporting porin activity
C2M21_RS03535	COG3384	dioxygenase
C2M21_RS03540	COG0754	glutathionylspermidine amidase activity
C2M21_RS03555	COG0494	nUDIX hydrolase
C2M21_RS03560	COG3151	Protein conserved in bacteria
C2M21_RS03565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2M21_RS03570	COG3150	esterase
C2M21_RS03580	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2M21_RS03585	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2M21_RS03590	COG0642	Histidine kinase
C2M21_RS03600	COG3111	PFAM Bacterial OB fold (BOF) protein
C2M21_RS03605	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2M21_RS03610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2M21_RS03615	COG0204	Acyl-transferase
C2M21_RS03620	COG2132	Multicopper oxidase
C2M21_RS03625	COG1032	radical SAM domain protein
C2M21_RS03635	COG0656	L-ascorbic acid biosynthetic process
C2M21_RS03640	COG1979	alcohol dehydrogenase
C2M21_RS03645	COG2207	Transcriptional regulator
C2M21_RS03650	COG0586	Pfam SNARE associated Golgi protein
C2M21_RS03655	COG0626	cystathionine gamma-synthase activity
C2M21_RS03665	COG0848	biopolymer transport protein
C2M21_RS03670	COG2211	Major facilitator Superfamily
C2M21_RS03695	COG0625	glutathione transferase activity
C2M21_RS03705	COG0754	glutathionylspermidine amidase activity
C2M21_RS03710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2M21_RS03730	COG0583	DNA-binding transcription factor activity
C2M21_RS03735	COG0626	cystathionine gamma-synthase activity
C2M21_RS03795	COG1811	Na channel or pump
C2M21_RS03805	COG1982	Orn Lys Arg decarboxylase major
C2M21_RS03810	COG2211	Major facilitator Superfamily
C2M21_RS03825	COG1194	a g-specific adenine glycosylase
C2M21_RS03835	COG3171	Protein conserved in bacteria
C2M21_RS03845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2M21_RS03860	COG0762	integral membrane protein
C2M21_RS03865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2M21_RS03870	COG2805	Type II/IV secretion system protein
C2M21_RS03890	COG0189	ligase activity
C2M21_RS03895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2M21_RS03900	COG2356	endonuclease I
C2M21_RS03910	COG2814	Major facilitator Superfamily
C2M21_RS03945	COG0501	Belongs to the peptidase M48B family
C2M21_RS03950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2M21_RS03965	COG0191	fructose-bisphosphate aldolase activity
C2M21_RS03970	COG0668	transmembrane transport
C2M21_RS03980	COG2968	Membrane
C2M21_RS03995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2M21_RS04000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2M21_RS04020	COG0006	proline dipeptidase activity
C2M21_RS04025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2M21_RS04030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2M21_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS04055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2M21_RS04075	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS04080	COG1737	Transcriptional regulator
C2M21_RS04090	COG1272	protein, Hemolysin III
C2M21_RS04100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2M21_RS04110	COG0716	FMN binding
C2M21_RS04115	COG4974	Belongs to the 'phage' integrase family
C2M21_RS04125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2M21_RS04145	COG4942	peptidase
C2M21_RS04165	COG0582	viral genome integration into host DNA
C2M21_RS04230	COG2814	Major facilitator Superfamily
C2M21_RS04245	COG0667	Aldo Keto reductase
C2M21_RS04285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2M21_RS04290	COG1393	Belongs to the ArsC family
C2M21_RS04305	COG1538	Outer membrane efflux protein
C2M21_RS04310	COG1289	transmembrane transporter activity
C2M21_RS04330	COG2388	GCN5-related N-acetyl-transferase
C2M21_RS04340	COG3539	Fimbrial protein
C2M21_RS04345	COG3539	Fimbrial protein
C2M21_RS04350	COG3539	Fimbrial protein
C2M21_RS04355	COG3188	usher protein
C2M21_RS04360	COG3121	Chaperone
C2M21_RS04365	COG3539	Fimbrial protein
C2M21_RS04375	COG4974	Belongs to the 'phage' integrase family
C2M21_RS04380	COG0582	viral genome integration into host DNA
C2M21_RS04390	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2M21_RS04395	COG1846	Transcriptional regulator
C2M21_RS04400	COG0697	spore germination
C2M21_RS04450	COG0667	Aldo Keto reductase
C2M21_RS04455	COG0814	amino acid
C2M21_RS04470	COG0183	Belongs to the thiolase family
C2M21_RS04480	COG0823	Involved in the tonB-independent uptake of proteins
C2M21_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS04490	COG2814	Major facilitator Superfamily
C2M21_RS04520	COG3842	ATPase activity
C2M21_RS04525	COG0395	ABC-type sugar transport system, permease component
C2M21_RS04530	COG1175	transmembrane transport
C2M21_RS04535	COG1917	Cupin 2, conserved barrel domain protein
C2M21_RS04540	COG1794	racemase activity, acting on amino acids and derivatives
C2M21_RS04545	COG0583	DNA-binding transcription factor activity
C2M21_RS04555	COG1609	Transcriptional regulator
C2M21_RS04560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS04565	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS04570	COG2186	Transcriptional regulator
C2M21_RS04580	COG1609	Transcriptional regulator
C2M21_RS04605	COG0667	Aldo Keto reductase
C2M21_RS04615	COG0861	Integral membrane protein TerC family
C2M21_RS04650	COG2165	general secretion pathway protein
C2M21_RS04655	COG4795	General secretion pathway protein
C2M21_RS04665	COG4967	type IV pilus modification protein PilV
C2M21_RS04670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2M21_RS04675	COG1025	Belongs to the peptidase M16 family
C2M21_RS04680	COG1074	ATP-dependent DNA helicase activity
C2M21_RS04685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2M21_RS04695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2M21_RS04695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2M21_RS04700	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2M21_RS04705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2M21_RS04735	COG4656	Part of a membrane complex involved in electron transport
C2M21_RS04740	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS04740	COG1454	alcohol dehydrogenase
C2M21_RS04770	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2M21_RS04970	COG2885	chlorophyll binding
C2M21_RS05005	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2M21_RS05010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2M21_RS05015	COG2166	iron-sulfur cluster assembly
C2M21_RS05020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2M21_RS05030	COG0583	DNA-binding transcription factor activity
C2M21_RS05035	COG2363	Small membrane protein
C2M21_RS05045	COG1349	DNA-binding transcription factor activity
C2M21_RS05065	COG0738	Major facilitator superfamily
C2M21_RS05070	COG0235	Class ii aldolase
C2M21_RS05075	COG1454	alcohol dehydrogenase
C2M21_RS05090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2M21_RS05105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2M21_RS05110	COG2011	ABC-type metal ion transport system permease component
C2M21_RS05115	COG1464	Belongs to the NlpA lipoprotein family
C2M21_RS05125	COG0477	Major facilitator Superfamily
C2M21_RS05135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2M21_RS05140	COG1760	l-serine dehydratase
C2M21_RS05145	COG0814	amino acid
C2M21_RS05150	COG1611	Belongs to the LOG family
C2M21_RS05165	COG3098	single-species biofilm formation
C2M21_RS05170	COG0564	pseudouridine synthase activity
C2M21_RS05175	COG0716	FMN binding
C2M21_RS05180	COG2271	Major facilitator Superfamily
C2M21_RS05185	COG4948	Mandelate Racemase Muconate Lactonizing
C2M21_RS05190	COG4948	Mandelate Racemase Muconate Lactonizing
C2M21_RS05195	COG1929	Belongs to the glycerate kinase type-1 family
C2M21_RS05205	COG3437	response regulator, receiver
C2M21_RS05205	COG2205	protein histidine kinase activity
C2M21_RS05205	COG4999	Histidine kinase
C2M21_RS05205	COG3850	Histidine kinase
C2M21_RS05215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2M21_RS05220	COG3956	TIGRFAM MazG family protein
C2M21_RS05240	COG0602	queuosine metabolic process
C2M21_RS05245	COG0720	synthase
C2M21_RS05265	COG2234	aminopeptidase activity
C2M21_RS05325	COG1388	LysM domain
C2M21_RS05325	COG4942	peptidase
C2M21_RS05330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2M21_RS05355	COG0163	prenyltransferase activity
C2M21_RS05360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2M21_RS05405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS05410	COG4558	Periplasmic binding protein
C2M21_RS05415	COG3720	iron ion transport
C2M21_RS05435	COG0679	Auxin Efflux Carrier
C2M21_RS05450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2M21_RS05455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2M21_RS05460	COG1121	(ABC) transporter
C2M21_RS05470	COG1609	Transcriptional regulator
C2M21_RS05475	COG1940	carbohydrate kinase activity
C2M21_RS05480	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2M21_RS05485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS05490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS05495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS05505	COG4580	involved in the transport of maltose and maltodextrins
C2M21_RS05515	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS05525	COG0309	Hydrogenase expression formation protein (HypE)
C2M21_RS05530	COG0409	Hydrogenase expression formation protein
C2M21_RS05535	COG0298	carbon dioxide binding
C2M21_RS05540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2M21_RS05560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2M21_RS05565	COG0651	ATP synthesis coupled electron transport
C2M21_RS05570	COG0650	Formate hydrogenlyase subunit 4
C2M21_RS05575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2M21_RS05575	COG3261	NADH dehydrogenase
C2M21_RS05580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2M21_RS05585	COG3260	NADH ubiquinone oxidoreductase 20
C2M21_RS05595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2M21_RS05605	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS05610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2M21_RS05610	COG1263	PTS System
C2M21_RS05615	COG1609	Transcriptional regulator
C2M21_RS05620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2M21_RS05625	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2M21_RS05630	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2M21_RS05660	COG1349	DNA-binding transcription factor activity
C2M21_RS05665	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS05670	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS05680	COG3732	PTS system glucitol sorbitol-specific
C2M21_RS05685	COG3730	PTS system glucitol sorbitol-specific
C2M21_RS05690	COG2951	lytic endotransglycosylase activity
C2M21_RS05700	COG1121	(ABC) transporter
C2M21_RS05705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2M21_RS05715	COG1546	Belongs to the CinA family
C2M21_RS05740	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2M21_RS05770	COG2823	Periplasmic or secreted lipoprotein
C2M21_RS05775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2M21_RS05780	COG1238	metal cluster binding
C2M21_RS05800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2M21_RS05805	COG2814	Major facilitator Superfamily
C2M21_RS05810	COG1566	PFAM secretion protein HlyD family protein
C2M21_RS05815	COG1846	Transcriptional regulator
C2M21_RS05825	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2M21_RS05835	COG4176	ABC-type proline glycine betaine transport system permease component
C2M21_RS05850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2M21_RS05860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2M21_RS05865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2M21_RS05870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2M21_RS05875	COG4575	ribosome binding
C2M21_RS05900	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2M21_RS05915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2M21_RS05920	COG0640	Transcriptional regulator
C2M21_RS05930	COG0583	DNA-binding transcription factor activity
C2M21_RS05935	COG3284	Transcriptional regulator
C2M21_RS05945	COG3539	Fimbrial protein
C2M21_RS05950	COG3121	Chaperone
C2M21_RS05970	COG3188	usher protein
C2M21_RS05975	COG3121	Chaperone
C2M21_RS05980	COG3539	Fimbrial protein
C2M21_RS05985	COG2197	response regulator
C2M21_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS06010	COG0235	Class ii aldolase
C2M21_RS06015	COG1126	abc transporter atp-binding protein
C2M21_RS06020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS06060	COG3708	Transcriptional regulator
C2M21_RS06060	COG2207	Transcriptional regulator
C2M21_RS06125	COG0582	viral genome integration into host DNA
C2M21_RS06140	COG2867	negative regulation of translational initiation
C2M21_RS06155	COG0497	DNA recombination
C2M21_RS06175	COG4536	flavin adenine dinucleotide binding
C2M21_RS06180	COG4137	Cytochrome C assembly protein
C2M21_RS06185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2M21_RS06220	COG2885	chlorophyll binding
C2M21_RS06225	COG2199	diguanylate cyclase activity
C2M21_RS06235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2M21_RS06240	COG1605	Chorismate mutase
C2M21_RS06240	COG0287	Prephenate dehydrogenase
C2M21_RS06250	COG1605	Chorismate mutase
C2M21_RS06250	COG0077	Prephenate dehydratase
C2M21_RS06260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2M21_RS06265	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2M21_RS06280	COG0542	response to heat
C2M21_RS06305	COG0477	Major facilitator Superfamily
C2M21_RS06310	COG5544	Lipoprotein
C2M21_RS06315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2M21_RS06325	COG3148	PFAM DTW domain containing protein
C2M21_RS06330	COG3118	belongs to the thioredoxin family
C2M21_RS06335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2M21_RS06350	COG0513	Belongs to the DEAD box helicase family
C2M21_RS06360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2M21_RS06375	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2M21_RS06380	COG3026	antisigma factor binding
C2M21_RS06385	COG3086	response to oxidative stress
C2M21_RS06395	COG0681	Belongs to the peptidase S26 family
C2M21_RS06415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2M21_RS06425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2M21_RS06430	COG1737	Transcriptional regulator
C2M21_RS06435	COG0560	Phosphoserine phosphatase
C2M21_RS06450	COG0047	phosphoribosylformylglycinamidine synthase activity
C2M21_RS06450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2M21_RS06460	COG2205	protein histidine kinase activity
C2M21_RS06465	COG3170	Tfp pilus assembly protein FimV
C2M21_RS06470	COG2204	response regulator
C2M21_RS06475	COG0347	Belongs to the P(II) protein family
C2M21_RS06480	COG1017	nitric oxide dioxygenase activity
C2M21_RS06480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2M21_RS06490	COG2259	Doxx family
C2M21_RS06495	COG1940	carbohydrate kinase activity
C2M21_RS06500	COG0457	Tetratricopeptide repeat
C2M21_RS06505	COG2814	Major facilitator Superfamily
C2M21_RS06505	COG0477	Major facilitator Superfamily
C2M21_RS06510	COG2017	converts alpha-aldose to the beta-anomer
C2M21_RS06515	COG2814	Major facilitator Superfamily
C2M21_RS06520	COG3711	transcriptional antiterminator
C2M21_RS06525	COG3683	transport system, periplasmic component
C2M21_RS06530	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2M21_RS06560	COG0822	iron-sulfur transferase activity
C2M21_RS06580	COG0633	Ferredoxin
C2M21_RS06585	COG2975	iron-sulfur cluster assembly
C2M21_RS06605	COG2897	thiosulfate sulfurtransferase activity
C2M21_RS06610	COG2373	Large extracellular alpha-helical protein
C2M21_RS06615	COG4953	penicillin-binding protein 1C
C2M21_RS06650	COG2976	Protein conserved in bacteria
C2M21_RS06690	COG1645	bacterial-type flagellum-dependent swarming motility
C2M21_RS06700	COG0517	IMP dehydrogenase activity
C2M21_RS06700	COG0516	GMP reductase activity
C2M21_RS06710	COG3119	arylsulfatase activity
C2M21_RS06715	COG0641	radical SAM
C2M21_RS06735	COG2200	EAL domain
C2M21_RS06750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2M21_RS06765	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS06775	COG2233	PERMEase
C2M21_RS06790	COG1393	Belongs to the ArsC family
C2M21_RS06795	COG4783	chaperone-mediated protein folding
C2M21_RS06800	COG0628	permease
C2M21_RS06805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2M21_RS06810	COG2716	regulation of RNA biosynthetic process
C2M21_RS06820	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2M21_RS06830	COG2321	neutral zinc metallopeptidase
C2M21_RS06835	COG1444	tRNA N-acetyltransferase activity
C2M21_RS06840	COG0400	carboxylic ester hydrolase activity
C2M21_RS06855	COG1393	Belongs to the ArsC family
C2M21_RS06865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2M21_RS06875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2M21_RS06875	COG0493	'glutamate synthase
C2M21_RS06885	COG5342	invasion associated locus B
C2M21_RS06890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2M21_RS06895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2M21_RS06905	COG4810	utilization protein
C2M21_RS06995	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2M21_RS07015	COG2837	iron assimilation
C2M21_RS07025	COG4150	thiosulfate binding
C2M21_RS07030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2M21_RS07035	COG4208	sulfate ABC transporter
C2M21_RS07040	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2M21_RS07050	COG4319	ketosteroid isomerase
C2M21_RS07085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2M21_RS07105	COG3530	Putative quorum-sensing-regulated virulence factor
C2M21_RS07110	COG0385	Bile acid
C2M21_RS07115	COG0583	DNA-binding transcription factor activity
C2M21_RS07150	COG3415	Transposase
C2M21_RS07155	COG3415	Transposase
C2M21_RS07170	COG2200	EAL domain
C2M21_RS07170	COG2199	diguanylate cyclase activity
C2M21_RS07175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2M21_RS07190	COG0667	Aldo Keto reductase
C2M21_RS07195	COG3961	Belongs to the TPP enzyme family
C2M21_RS07210	COG3279	Response regulator of the LytR AlgR family
C2M21_RS07215	COG3275	phosphorelay sensor kinase activity
C2M21_RS07225	COG0436	Aminotransferase
C2M21_RS07235	COG2807	transmembrane transport
C2M21_RS07240	COG0590	tRNA wobble adenosine to inosine editing
C2M21_RS07245	COG0583	DNA-binding transcription factor activity
C2M21_RS07390	COG0653	protein targeting
C2M21_RS07450	COG3772	lysozyme
C2M21_RS07475	COG5410	chromosome segregation
C2M21_RS07540	COG3646	Phage regulatory protein
C2M21_RS07550	COG0741	lytic transglycosylase activity
C2M21_RS07550	COG1196	nuclear chromosome segregation
C2M21_RS07550	COG0739	heme binding
C2M21_RS07650	COG0582	viral genome integration into host DNA
C2M21_RS07660	COG2116	formate transmembrane transporter activity
C2M21_RS07665	COG2853	Lipoprotein
C2M21_RS07675	COG3691	Protein conserved in bacteria
C2M21_RS07690	COG2062	phosphohistidine phosphatase, SixA
C2M21_RS07715	COG0730	response to heat
C2M21_RS07720	COG3101	peptidyl-lysine hydroxylation
C2M21_RS07735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2M21_RS07755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2M21_RS07765	COG0586	Pfam SNARE associated Golgi protein
C2M21_RS07775	COG0285	dihydrofolate synthase activity
C2M21_RS07780	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2M21_RS07785	COG1286	toxin biosynthetic process
C2M21_RS07790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2M21_RS07795	COG0163	prenyltransferase activity
C2M21_RS07815	COG4160	amino acid transport
C2M21_RS07820	COG4598	ABC transporter
C2M21_RS07830	COG1090	epimerase
C2M21_RS07835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2M21_RS07840	COG0625	glutathione transferase activity
C2M21_RS07845	COG0625	glutathione transferase activity
C2M21_RS07850	COG0622	Phosphoesterase
C2M21_RS07855	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2M21_RS07860	COG0280	phosphate acetyltransferase
C2M21_RS07860	COG0857	belongs to the CobB CobQ family
C2M21_RS07880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2M21_RS07885	COG0490	domain, Protein
C2M21_RS07885	COG0471	metal ion transport
C2M21_RS07895	COG0436	Aminotransferase
C2M21_RS07900	COG0583	DNA-binding transcription factor activity
C2M21_RS07950	COG0839	Belongs to the complex I subunit 6 family
C2M21_RS07960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2M21_RS07965	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2M21_RS07980	COG2153	protein acetylation
C2M21_RS07985	COG1169	isochorismate synthase
C2M21_RS08010	COG0318	PFAM AMP-dependent synthetase and ligase
C2M21_RS08020	COG5464	transposase or invertase
C2M21_RS08035	COG1414	Transcriptional regulator
C2M21_RS08045	COG2271	Major facilitator Superfamily
C2M21_RS08055	COG0247	lactate metabolic process
C2M21_RS08065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2M21_RS08070	COG2271	Major facilitator Superfamily
C2M21_RS08075	COG0584	glycerophosphoryl diester phosphodiesterase
C2M21_RS08085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2M21_RS08115	COG0784	Response regulator, receiver
C2M21_RS08115	COG2205	protein histidine kinase activity
C2M21_RS08125	COG2198	Histidine kinase
C2M21_RS08125	COG0642	Histidine kinase
C2M21_RS08140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2M21_RS08140	COG2169	Transcriptional regulator
C2M21_RS08145	COG3145	DNA-N1-methyladenine dioxygenase activity
C2M21_RS08150	COG4615	Cyclic peptide transporter
C2M21_RS08155	COG2239	Acts as a magnesium transporter
C2M21_RS08160	COG0659	secondary active sulfate transmembrane transporter activity
C2M21_RS08175	COG0628	permease
C2M21_RS08200	COG1349	DNA-binding transcription factor activity
C2M21_RS08205	COG0494	nUDIX hydrolase
C2M21_RS08225	COG1061	Type III restriction enzyme res subunit
C2M21_RS08230	COG1187	pseudouridine synthase activity
C2M21_RS08235	COG2814	Major facilitator Superfamily
C2M21_RS08245	COG4172	Belongs to the ABC transporter superfamily
C2M21_RS08250	COG4239	(ABC) transporter, permease
C2M21_RS08255	COG4174	ABC transporter (Permease)
C2M21_RS08260	COG4166	transmembrane transport
C2M21_RS08265	COG2200	EAL domain
C2M21_RS08270	COG0791	NLP P60 protein
C2M21_RS08275	COG0671	phosphoesterase, PA-phosphatase related
C2M21_RS08280	COG0523	cobalamin synthesis protein
C2M21_RS08285	COG0246	Mannitol dehydrogenase
C2M21_RS08290	COG1312	Catalyzes the dehydration of D-mannonate
C2M21_RS08320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS08320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS08325	COG1105	Belongs to the carbohydrate kinase PfkB family
C2M21_RS08330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2M21_RS08330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2M21_RS08330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2M21_RS08340	COG2855	membrane
C2M21_RS08350	COG0583	DNA-binding transcription factor activity
C2M21_RS08355	COG0833	amino acid
C2M21_RS08370	COG4771	TonB-dependent receptor
C2M21_RS08385	COG2311	Membrane
C2M21_RS08400	COG1129	ABC transporter
C2M21_RS08410	COG2949	membrane
C2M21_RS08425	COG1346	cytolysis
C2M21_RS08435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2M21_RS08440	COG3659	wide pore channel activity
C2M21_RS08455	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS08465	COG1538	Outer membrane efflux protein
C2M21_RS08470	COG0586	Pfam SNARE associated Golgi protein
C2M21_RS08480	COG1686	Belongs to the peptidase S11 family
C2M21_RS08495	COG0277	FAD linked oxidase domain protein
C2M21_RS08500	COG1472	Belongs to the glycosyl hydrolase 3 family
C2M21_RS08505	COG1732	Glycine betaine
C2M21_RS08510	COG1174	glycine betaine transport
C2M21_RS08515	COG1125	glycine betaine transport
C2M21_RS08520	COG1174	glycine betaine transport
C2M21_RS08530	COG3275	phosphorelay sensor kinase activity
C2M21_RS08540	COG4807	Protein conserved in bacteria
C2M21_RS08560	COG5455	response to cobalt ion
C2M21_RS08565	COG0583	DNA-binding transcription factor activity
C2M21_RS08570	COG2252	PERMEase
C2M21_RS08580	COG0583	DNA-binding transcription factor activity
C2M21_RS08600	COG0351	phosphomethylpyrimidine kinase
C2M21_RS08605	COG1830	Aldolase
C2M21_RS08640	COG1070	Carbohydrate kinase
C2M21_RS08650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2M21_RS08655	COG4948	Mandelate Racemase Muconate Lactonizing
C2M21_RS08660	COG0747	negative chemotaxis
C2M21_RS08665	COG0601	transmembrane transport
C2M21_RS08670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2M21_RS08675	COG0444	Belongs to the ABC transporter superfamily
C2M21_RS08680	COG4608	Belongs to the ABC transporter superfamily
C2M21_RS08690	COG0826	peptidase U32
C2M21_RS08695	COG0745	RESPONSE REGULATOR receiver
C2M21_RS08700	COG2205	protein histidine kinase activity
C2M21_RS08725	COG1301	dicarboxylic acid transport
C2M21_RS08740	COG5002	protein histidine kinase activity
C2M21_RS08745	COG0443	Heat shock 70 kDa protein
C2M21_RS08750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2M21_RS08765	COG2982	Protein involved in outer membrane biogenesis
C2M21_RS08770	COG1253	flavin adenine dinucleotide binding
C2M21_RS08805	COG5039	Polysaccharide pyruvyl transferase
C2M21_RS08910	COG0438	transferase activity, transferring glycosyl groups
C2M21_RS08915	COG1215	transferase activity, transferring glycosyl groups
C2M21_RS08935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2M21_RS08965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2M21_RS08970	COG0583	DNA-binding transcription factor activity
C2M21_RS08980	COG0531	amino acid
C2M21_RS08985	COG0640	Transcriptional regulator
C2M21_RS08990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2M21_RS08995	COG2925	Exonuclease
C2M21_RS09010	COG1289	transmembrane transporter activity
C2M21_RS09030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2M21_RS09040	COG1942	4-Oxalocrotonate Tautomerase
C2M21_RS09045	COG0583	DNA-binding transcription factor activity
C2M21_RS09050	COG0095	Lipoate-protein ligase
C2M21_RS09055	COG0477	Major facilitator Superfamily
C2M21_RS09070	COG5001	Diguanylate cyclase
C2M21_RS09070	COG3300	MHYT domain
C2M21_RS09075	COG3615	Tellurite resistance protein tehB
C2M21_RS09085	COG0583	DNA-binding transcription factor activity
C2M21_RS09100	COG3706	GGDEF domain
C2M21_RS09120	COG0534	Mate efflux family protein
C2M21_RS09130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2M21_RS09150	COG0604	alcohol dehydrogenase
C2M21_RS09155	COG1309	transcriptional regulator
C2M21_RS09160	COG0025	NhaP-type Na H and K H
C2M21_RS09190	COG0251	oxidation-reduction process
C2M21_RS09210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2M21_RS09225	COG1418	mRNA catabolic process
C2M21_RS09235	COG3727	T/G mismatch-specific endonuclease activity
C2M21_RS09240	COG0697	spore germination
C2M21_RS09245	COG2354	Protein conserved in bacteria
C2M21_RS09275	COG0366	Alpha amylase catalytic
C2M21_RS09280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS09290	COG0765	amino acid transport
C2M21_RS09295	COG1126	abc transporter atp-binding protein
C2M21_RS09300	COG2197	response regulator
C2M21_RS09310	COG2197	response regulator
C2M21_RS09350	COG3012	SEC-C Motif Domain Protein
C2M21_RS09350	COG3318	Belongs to the UPF0149 family
C2M21_RS09355	COG0814	amino acid
C2M21_RS09365	COG1528	Iron-storage protein
C2M21_RS09380	COG0477	Major facilitator Superfamily
C2M21_RS09390	COG2211	Major facilitator Superfamily
C2M21_RS09400	COG1528	Iron-storage protein
C2M21_RS09410	COG1879	ABC-type sugar transport system periplasmic component
C2M21_RS09420	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS09445	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2M21_RS09455	COG3102	Protein conserved in bacteria
C2M21_RS09475	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2M21_RS09480	COG1801	Protein of unknown function DUF72
C2M21_RS09485	COG1335	isochorismatase
C2M21_RS09495	COG0494	nUDIX hydrolase
C2M21_RS09520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2M21_RS09530	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2M21_RS09535	COG0739	heme binding
C2M21_RS09540	COG1560	Kdo2-lipid A biosynthetic process
C2M21_RS09550	COG1737	Transcriptional regulator
C2M21_RS09565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2M21_RS09570	COG0129	dihydroxy-acid dehydratase activity
C2M21_RS09575	COG0800	Aldolase
C2M21_RS09585	COG3141	response to X-ray
C2M21_RS09590	COG2979	Protein of unknown function (DUF533)
C2M21_RS09595	COG1770	oligopeptidase
C2M21_RS09600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2M21_RS09610	COG2372	response to copper ion
C2M21_RS09615	COG1276	copper resistance
C2M21_RS09630	COG2990	Protein conserved in bacteria
C2M21_RS09655	COG3008	intermembrane lipid transfer
C2M21_RS09660	COG2995	paraquat-inducible protein a
C2M21_RS09665	COG1956	GAF domain-containing protein
C2M21_RS09685	COG2814	Major facilitator Superfamily
C2M21_RS09695	COG1414	Transcriptional regulator
C2M21_RS09735	COG0768	penicillin binding
C2M21_RS09740	COG2226	methyltransferase
C2M21_RS09755	COG3716	PTS system mannose fructose sorbose family IID component
C2M21_RS09760	COG3715	PTS system
C2M21_RS09765	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS09765	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2M21_RS09770	COG1253	flavin adenine dinucleotide binding
C2M21_RS09775	COG2200	EAL domain
C2M21_RS09780	COG1760	l-serine dehydratase
C2M21_RS09800	COG0251	oxidation-reduction process
C2M21_RS09805	COG1199	ATP-dependent helicase activity
C2M21_RS09815	COG3065	identical protein binding
C2M21_RS09825	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2M21_RS09835	COG2894	cell division
C2M21_RS09850	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2M21_RS09900	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2M21_RS09910	COG4774	siderophore transport
C2M21_RS09925	COG2308	Evidence 4 Homologs of previously reported genes of
C2M21_RS09975	COG0583	DNA-binding transcription factor activity
C2M21_RS09980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2M21_RS09995	COG1882	Formate acetyltransferase
C2M21_RS10025	COG0583	DNA-binding transcription factor activity
C2M21_RS10055	COG0583	DNA-binding transcription factor activity
C2M21_RS10070	COG3122	Protein conserved in bacteria
C2M21_RS10095	COG2885	chlorophyll binding
C2M21_RS10110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2M21_RS10125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2M21_RS10200	COG0012	GTP binding
C2M21_RS10220	COG0659	secondary active sulfate transmembrane transporter activity
C2M21_RS10250	COG2890	protein-(glutamine-N5) methyltransferase activity
C2M21_RS10270	COG0387	Pfam Sodium calcium exchanger
C2M21_RS10275	COG4572	Cation transport regulator
C2M21_RS10280	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2M21_RS10290	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2M21_RS10295	COG3707	response regulator
C2M21_RS10300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2M21_RS10310	COG1116	anion transmembrane transporter activity
C2M21_RS10315	COG2146	nitrite reductase [NAD(P)H] activity
C2M21_RS10315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2M21_RS10320	COG0243	molybdopterin cofactor binding
C2M21_RS10325	COG4932	domain protein
C2M21_RS10330	COG2197	response regulator
C2M21_RS10335	COG3850	Histidine kinase
C2M21_RS10340	COG2223	nitrite transmembrane transporter activity
C2M21_RS10345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2M21_RS10350	COG1140	nitrate reductase beta subunit
C2M21_RS10355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2M21_RS10360	COG2181	nitrate reductase activity
C2M21_RS10370	COG1522	sequence-specific DNA binding
C2M21_RS10410	COG0788	formyltetrahydrofolate deformylase activity
C2M21_RS10420	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2M21_RS10425	COG0745	RESPONSE REGULATOR receiver
C2M21_RS10430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2M21_RS10435	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2M21_RS10440	COG1435	thymidine kinase activity
C2M21_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS10445	COG1454	alcohol dehydrogenase
C2M21_RS10455	COG2095	MarC family integral membrane protein
C2M21_RS10460	COG4166	transmembrane transport
C2M21_RS10465	COG0601	transmembrane transport
C2M21_RS10470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2M21_RS10475	COG0444	Belongs to the ABC transporter superfamily
C2M21_RS10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2M21_RS10505	COG2353	YceI-like domain
C2M21_RS10510	COG2350	Protein conserved in bacteria
C2M21_RS10520	COG3001	Fructosamine kinase
C2M21_RS10530	COG1105	Belongs to the carbohydrate kinase PfkB family
C2M21_RS10535	COG3137	Salt-induced outer membrane protein
C2M21_RS10755	COG3772	lysozyme
C2M21_RS10925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2M21_RS10985	COG0583	DNA-binding transcription factor activity
C2M21_RS11005	COG0386	Belongs to the glutathione peroxidase family
C2M21_RS11015	COG0791	NLP P60 protein
C2M21_RS11025	COG4256	Hemin uptake protein
C2M21_RS11030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2M21_RS11040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2M21_RS11040	COG0574	Belongs to the PEP-utilizing enzyme family
C2M21_RS11050	COG0628	permease
C2M21_RS11055	COG0277	FAD linked oxidase domain protein
C2M21_RS11055	COG0247	lactate metabolic process
C2M21_RS11060	COG2050	protein possibly involved in aromatic compounds catabolism
C2M21_RS11065	COG2261	transglycosylase associated protein
C2M21_RS11095	COG1120	ATPase activity
C2M21_RS11100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS11110	COG0583	DNA-binding transcription factor activity
C2M21_RS11135	COG1304	FMN binding
C2M21_RS11140	COG1309	transcriptional regulator
C2M21_RS11155	COG0316	Belongs to the HesB IscA family
C2M21_RS11160	COG0719	Fe-S assembly protein
C2M21_RS11165	COG0396	ATPase activity
C2M21_RS11170	COG0719	Fe-S assembly protein
C2M21_RS11185	COG1376	ErfK ybiS ycfS ynhG family protein
C2M21_RS11210	COG1309	transcriptional regulator
C2M21_RS11215	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2M21_RS11215	COG1082	Xylose isomerase domain protein TIM barrel
C2M21_RS11220	COG2271	Major facilitator Superfamily
C2M21_RS11225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2M21_RS11235	COG1120	ATPase activity
C2M21_RS11240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS11245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2M21_RS11250	COG1414	Transcriptional regulator
C2M21_RS11285	COG2814	Major facilitator Superfamily
C2M21_RS11305	COG0583	DNA-binding transcription factor activity
C2M21_RS11310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2M21_RS11330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2M21_RS11335	COG1116	anion transmembrane transporter activity
C2M21_RS11340	COG4774	siderophore transport
C2M21_RS11345	COG1120	ATPase activity
C2M21_RS11350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS11355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS11375	COG0765	amino acid transport
C2M21_RS11410	COG1473	amidohydrolase
C2M21_RS11415	COG3383	formate dehydrogenase (NAD+) activity
C2M21_RS11420	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2M21_RS11435	COG1175	transmembrane transport
C2M21_RS11470	COG4133	protoheme IX ABC transporter activity
C2M21_RS11475	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2M21_RS11480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2M21_RS11495	COG1138	Cytochrome C-type biogenesis protein
C2M21_RS11500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2M21_RS11505	COG3088	subunit of a heme lyase
C2M21_RS11505	COG4235	cytochrome complex assembly
C2M21_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS11560	COG2610	gluconate transmembrane transporter activity
C2M21_RS11565	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2M21_RS11575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2M21_RS11585	COG0583	DNA-binding transcription factor activity
C2M21_RS11615	COG2814	Major facilitator Superfamily
C2M21_RS11630	COG0277	FAD linked oxidase domain protein
C2M21_RS11635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2M21_RS11660	COG0402	S-adenosylhomocysteine deaminase activity
C2M21_RS11720	COG4608	Belongs to the ABC transporter superfamily
C2M21_RS11725	COG0444	Belongs to the ABC transporter superfamily
C2M21_RS11750	COG0346	lactoylglutathione lyase activity
C2M21_RS11755	COG1349	DNA-binding transcription factor activity
C2M21_RS11785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2M21_RS11840	COG0307	riboflavin synthase, alpha
C2M21_RS11845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2M21_RS11850	COG2814	Major facilitator Superfamily
C2M21_RS11855	COG0583	DNA-binding transcription factor activity
C2M21_RS11870	COG2814	Major facilitator Superfamily
C2M21_RS11885	COG0791	NLP P60 protein
C2M21_RS11890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2M21_RS11900	COG0346	lactoylglutathione lyase activity
C2M21_RS11905	COG1902	pentaerythritol trinitrate reductase activity
C2M21_RS11910	COG1309	transcriptional regulator
C2M21_RS11915	COG3313	Fe-S protein
C2M21_RS11920	COG4989	oxidoreductase activity
C2M21_RS11925	COG2032	superoxide dismutase activity
C2M21_RS11930	COG1289	transmembrane transporter activity
C2M21_RS11935	COG1566	PFAM secretion protein HlyD family protein
C2M21_RS11950	COG3706	GGDEF domain
C2M21_RS11965	COG3895	Periplasmic Protein
C2M21_RS11980	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2M21_RS11985	COG0625	glutathione transferase activity
C2M21_RS12000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2M21_RS12010	COG4659	FMN binding
C2M21_RS12045	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS12055	COG0673	inositol 2-dehydrogenase activity
C2M21_RS12065	COG2814	Major facilitator Superfamily
C2M21_RS12085	COG3038	cytochrome b561
C2M21_RS12105	COG0583	DNA-binding transcription factor activity
C2M21_RS12110	COG3485	protocatechuate 3,4-dioxygenase
C2M21_RS12115	COG3485	protocatechuate 3,4-dioxygenase
C2M21_RS12120	COG5383	Protein conserved in bacteria
C2M21_RS12125	COG2272	Belongs to the type-B carboxylesterase lipase family
C2M21_RS12140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2M21_RS12145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2M21_RS12150	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2M21_RS12155	COG0500	methyltransferase
C2M21_RS12170	COG2207	Transcriptional regulator
C2M21_RS12170	COG3708	Transcriptional regulator
C2M21_RS12175	COG3135	benzoate transporter
C2M21_RS12180	COG1396	sequence-specific DNA binding
C2M21_RS12190	COG0826	peptidase U32
C2M21_RS12210	COG1294	oxidase, subunit
C2M21_RS12215	COG1271	oxidase subunit
C2M21_RS12220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2M21_RS12225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2M21_RS12230	COG3842	ATPase activity
C2M21_RS12235	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2M21_RS12240	COG1177	transmembrane transport
C2M21_RS12245	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS12275	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS12280	COG0747	negative chemotaxis
C2M21_RS12290	COG3238	Protein conserved in bacteria
C2M21_RS12295	COG1247	-acetyltransferase
C2M21_RS12305	COG2130	NADP-dependent
C2M21_RS12315	COG3691	Protein conserved in bacteria
C2M21_RS12320	COG1228	amidohydrolase
C2M21_RS12325	COG4772	TonB-dependent receptor
C2M21_RS12350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2M21_RS12355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2M21_RS12360	COG1473	amidohydrolase
C2M21_RS12365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2M21_RS12370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS12380	COG0765	amino acid transport
C2M21_RS12385	COG1126	abc transporter atp-binding protein
C2M21_RS12395	COG0625	glutathione transferase activity
C2M21_RS12420	COG2211	Major facilitator Superfamily
C2M21_RS12435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2M21_RS12440	COG3842	ATPase activity
C2M21_RS12445	COG1840	ABC-type Fe3 transport system, periplasmic component
C2M21_RS12450	COG1178	ABC-type Fe3 transport system permease component
C2M21_RS12455	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2M21_RS12460	COG2181	nitrate reductase activity
C2M21_RS12465	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2M21_RS12470	COG1140	nitrate reductase beta subunit
C2M21_RS12475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2M21_RS12480	COG2223	nitrite transmembrane transporter activity
C2M21_RS12495	COG1414	Transcriptional regulator
C2M21_RS12500	COG4948	Mandelate Racemase Muconate Lactonizing
C2M21_RS12505	COG4829	muconolactone delta-isomerase
C2M21_RS12510	COG3485	protocatechuate 3,4-dioxygenase
C2M21_RS12520	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2M21_RS12540	COG3383	formate dehydrogenase (NAD+) activity
C2M21_RS12540	COG0243	molybdopterin cofactor binding
C2M21_RS12545	COG0243	molybdopterin cofactor binding
C2M21_RS12545	COG3383	formate dehydrogenase (NAD+) activity
C2M21_RS12550	COG0437	4 iron, 4 sulfur cluster binding
C2M21_RS12555	COG2864	formate dehydrogenase
C2M21_RS12570	COG2326	polyphosphate kinase activity
C2M21_RS12580	COG2814	Major facilitator Superfamily
C2M21_RS12590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2M21_RS12600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2M21_RS12610	COG0747	negative chemotaxis
C2M21_RS12615	COG1064	alcohol dehydrogenase
C2M21_RS12630	COG0488	(ABC) transporter
C2M21_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS12670	COG3729	General stress protein
C2M21_RS12690	COG3685	Protein conserved in bacteria
C2M21_RS12700	COG0366	Alpha amylase catalytic
C2M21_RS12710	COG2323	membrane
C2M21_RS12720	COG3111	PFAM Bacterial OB fold (BOF) protein
C2M21_RS12725	COG1764	response to oxidative stress
C2M21_RS12750	COG3781	membrane
C2M21_RS12755	COG0243	molybdopterin cofactor binding
C2M21_RS12760	COG0583	DNA-binding transcription factor activity
C2M21_RS12765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS12790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS12795	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2M21_RS12800	COG2814	Major facilitator Superfamily
C2M21_RS12810	COG1285	pathogenesis
C2M21_RS12815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2M21_RS12835	COG0519	Catalyzes the synthesis of GMP from XMP
C2M21_RS12835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2M21_RS12875	COG0596	Alpha beta hydrolase
C2M21_RS12885	COG2205	protein histidine kinase activity
C2M21_RS12895	COG0583	DNA-binding transcription factor activity
C2M21_RS12900	COG0076	glutamate decarboxylase activity
C2M21_RS12905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2M21_RS12910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2M21_RS12915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2M21_RS12920	COG1116	anion transmembrane transporter activity
C2M21_RS12925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2M21_RS12940	COG0673	inositol 2-dehydrogenase activity
C2M21_RS12955	COG3706	GGDEF domain
C2M21_RS12960	COG0402	S-adenosylhomocysteine deaminase activity
C2M21_RS12965	COG1953	Uracil, thiamine, allantoin
C2M21_RS13000	COG0596	Alpha beta hydrolase
C2M21_RS13015	COG2207	Transcriptional regulator
C2M21_RS13035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2M21_RS13095	COG0765	amino acid transport
C2M21_RS13105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2M21_RS13115	COG2070	2-Nitropropane dioxygenase
C2M21_RS13120	COG0583	DNA-binding transcription factor activity
C2M21_RS13130	COG1902	pentaerythritol trinitrate reductase activity
C2M21_RS13135	COG4529	Protein conserved in bacteria
C2M21_RS13140	COG0477	Major facilitator Superfamily
C2M21_RS13170	COG2223	nitrite transmembrane transporter activity
C2M21_RS13180	COG1609	Transcriptional regulator
C2M21_RS13185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS13195	COG3037	sugar-specific permease SgaT UlaA
C2M21_RS13200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2M21_RS13210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2M21_RS13215	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2M21_RS13215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2M21_RS13215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2M21_RS13225	COG1652	LysM domain
C2M21_RS13250	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2M21_RS13250	COG0456	acetyltransferase
C2M21_RS13260	COG0667	Aldo Keto reductase
C2M21_RS13265	COG0667	Aldo Keto reductase
C2M21_RS13270	COG3386	PFAM SMP-30 Gluconolaconase
C2M21_RS13275	COG0667	Aldo Keto reductase
C2M21_RS13295	COG3850	Histidine kinase
C2M21_RS13295	COG5002	protein histidine kinase activity
C2M21_RS13330	COG2186	Transcriptional regulator
C2M21_RS13335	COG1263	PTS System
C2M21_RS13335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2M21_RS13345	COG2814	Major facilitator Superfamily
C2M21_RS13350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS13350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS13360	COG2819	hydrolase of the alpha beta superfamily
C2M21_RS13365	COG3300	MHYT domain
C2M21_RS13365	COG5001	Diguanylate cyclase
C2M21_RS13400	COG3188	usher protein
C2M21_RS13415	COG1649	PFAM Uncharacterised BCR, COG1649
C2M21_RS13420	COG3550	peptidyl-serine autophosphorylation
C2M21_RS13425	COG1396	sequence-specific DNA binding
C2M21_RS13430	COG2351	hydroxyisourate hydrolase activity
C2M21_RS13435	COG3648	Uricase
C2M21_RS13435	COG3195	allantoin biosynthetic process
C2M21_RS13440	COG2233	PERMEase
C2M21_RS13470	COG2207	Transcriptional regulator
C2M21_RS13485	COG4628	conserved protein (DUF2132)
C2M21_RS13505	COG2011	ABC-type metal ion transport system permease component
C2M21_RS13510	COG2070	2-Nitropropane dioxygenase
C2M21_RS13520	COG0477	Major facilitator Superfamily
C2M21_RS13590	COG2199	diguanylate cyclase activity
C2M21_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS13610	COG0583	DNA-binding transcription factor activity
C2M21_RS13620	COG0039	L-malate dehydrogenase activity
C2M21_RS13625	COG1349	DNA-binding transcription factor activity
C2M21_RS13630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2M21_RS13635	COG3395	kinase activity
C2M21_RS13645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2M21_RS13650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2M21_RS13655	COG2271	Major facilitator Superfamily
C2M21_RS13680	COG4977	sequence-specific DNA binding
C2M21_RS13690	COG0697	spore germination
C2M21_RS13695	COG2814	Major facilitator Superfamily
C2M21_RS13710	COG1129	ABC transporter
C2M21_RS13725	COG0683	leucine binding
C2M21_RS13730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2M21_RS13765	COG2223	nitrite transmembrane transporter activity
C2M21_RS13770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2M21_RS13785	COG1349	DNA-binding transcription factor activity
C2M21_RS13795	COG2084	Dehydrogenase
C2M21_RS13800	COG3395	kinase activity
C2M21_RS13805	COG0235	Class ii aldolase
C2M21_RS13810	COG3622	Belongs to the hyi family
C2M21_RS13815	COG2610	gluconate transmembrane transporter activity
C2M21_RS13820	COG3708	Transcriptional regulator
C2M21_RS13820	COG2207	Transcriptional regulator
C2M21_RS13835	COG2200	EAL domain
C2M21_RS13840	COG1546	Belongs to the CinA family
C2M21_RS13845	COG0071	Belongs to the small heat shock protein (HSP20) family
C2M21_RS13865	COG2135	peptidase activity
C2M21_RS13870	COG2207	Transcriptional regulator
C2M21_RS13885	COG4221	oxidoreductase activity
C2M21_RS13890	COG1802	Transcriptional regulator
C2M21_RS13895	COG0589	response to stress
C2M21_RS13900	COG0246	Mannitol dehydrogenase
C2M21_RS13905	COG2271	Major facilitator Superfamily
C2M21_RS13920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2M21_RS13935	COG0243	molybdopterin cofactor binding
C2M21_RS13940	COG0437	4 iron, 4 sulfur cluster binding
C2M21_RS13945	COG3302	dmso reductase anchor subunit
C2M21_RS13960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2M21_RS13965	COG1940	carbohydrate kinase activity
C2M21_RS13970	COG0583	DNA-binding transcription factor activity
C2M21_RS13975	COG2814	Major facilitator Superfamily
C2M21_RS13980	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2M21_RS13990	COG3591	Belongs to the peptidase S1B family
C2M21_RS14010	COG0628	permease
C2M21_RS14040	COG0679	Auxin Efflux Carrier
C2M21_RS14050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2M21_RS14075	COG3290	protein histidine kinase activity
C2M21_RS14080	COG4565	transcriptional regulatory protein
C2M21_RS14105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2M21_RS14105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2M21_RS14125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2M21_RS14130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2M21_RS14140	COG0183	Belongs to the thiolase family
C2M21_RS14145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2M21_RS14155	COG1414	Transcriptional regulator
C2M21_RS14160	COG2840	Smr protein MutS2
C2M21_RS14165	COG0583	DNA-binding transcription factor activity
C2M21_RS14175	COG1473	amidohydrolase
C2M21_RS14180	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2M21_RS14195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2M21_RS14210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2M21_RS14215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2M21_RS14235	COG0531	amino acid
C2M21_RS14245	COG3136	membrane protein required for alginate biosynthesis
C2M21_RS14250	COG0745	RESPONSE REGULATOR receiver
C2M21_RS14265	COG2205	protein histidine kinase activity
C2M21_RS14275	COG0114	fumarate hydratase activity
C2M21_RS14280	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2M21_RS14280	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2M21_RS14285	COG1482	cell wall glycoprotein biosynthetic process
C2M21_RS14290	COG5339	Protein conserved in bacteria
C2M21_RS14295	COG1609	Transcriptional regulator
C2M21_RS14300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2M21_RS14300	COG1263	PTS System
C2M21_RS14305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2M21_RS14330	COG2391	methyltransferase activity
C2M21_RS14335	COG0425	Belongs to the sulfur carrier protein TusA family
C2M21_RS14340	COG5562	phage envelope protein
C2M21_RS14345	COG0401	homolog of Blt101
C2M21_RS14350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2M21_RS14355	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS14360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2M21_RS14365	COG0477	Major facilitator Superfamily
C2M21_RS14370	COG1113	amino acid transport
C2M21_RS14375	COG2988	succinylglutamate desuccinylase activity
C2M21_RS14380	COG3724	N-succinylarginine dihydrolase activity
C2M21_RS14385	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS14390	COG3138	arginine N-succinyltransferase
C2M21_RS14395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2M21_RS14400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2M21_RS14405	COG0667	Aldo Keto reductase
C2M21_RS14410	COG0583	DNA-binding transcription factor activity
C2M21_RS14435	COG4122	O-methyltransferase activity
C2M21_RS14440	COG1643	Atp-dependent helicase
C2M21_RS14455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2M21_RS14460	COG3327	negative regulation of DNA-templated transcription, initiation
C2M21_RS14465	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2M21_RS14470	COG0183	Belongs to the thiolase family
C2M21_RS14475	COG2050	protein possibly involved in aromatic compounds catabolism
C2M21_RS14480	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2M21_RS14485	COG1024	Enoyl-CoA hydratase
C2M21_RS14490	COG1024	Enoyl-CoA hydratase
C2M21_RS14495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2M21_RS14500	COG2151	metal-sulfur cluster biosynthetic enzyme
C2M21_RS14505	COG3396	Phenylacetate-CoA oxygenase
C2M21_RS14510	COG3460	Phenylacetate-CoA oxygenase
C2M21_RS14515	COG3396	Phenylacetate-CoA oxygenase
C2M21_RS14520	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS14520	COG2030	dehydratase
C2M21_RS14545	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS14550	COG2207	Transcriptional regulator
C2M21_RS14555	COG3784	Protein of unknown function (DUF1318)
C2M21_RS14565	COG2911	Protein conserved in bacteria
C2M21_RS14570	COG0586	Pfam SNARE associated Golgi protein
C2M21_RS14575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2M21_RS14580	COG3187	Heat shock protein
C2M21_RS14585	COG3042	response to heat
C2M21_RS14595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2M21_RS14595	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2M21_RS14595	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2M21_RS14595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2M21_RS14600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2M21_RS14610	COG0589	response to stress
C2M21_RS14620	COG0513	Belongs to the DEAD box helicase family
C2M21_RS14635	COG1349	DNA-binding transcription factor activity
C2M21_RS14640	COG0673	inositol 2-dehydrogenase activity
C2M21_RS14655	COG2011	ABC-type metal ion transport system permease component
C2M21_RS14670	COG0436	Aminotransferase
C2M21_RS14675	COG0604	alcohol dehydrogenase
C2M21_RS14700	COG0583	DNA-binding transcription factor activity
C2M21_RS14720	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS14725	COG1309	transcriptional regulator
C2M21_RS14730	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS14835	COG2885	chlorophyll binding
C2M21_RS14860	COG0693	protein deglycase activity
C2M21_RS14865	COG1078	dGTPase activity
C2M21_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS14875	COG0583	DNA-binding transcription factor activity
C2M21_RS14895	COG0656	L-ascorbic acid biosynthetic process
C2M21_RS14925	COG4166	transmembrane transport
C2M21_RS14930	COG2866	Carboxypeptidase
C2M21_RS14935	COG4948	Mandelate Racemase Muconate Lactonizing
C2M21_RS14940	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2M21_RS14945	COG3180	Ammonia monooxygenase
C2M21_RS14955	COG1486	melibiose metabolic process
C2M21_RS14960	COG0583	DNA-binding transcription factor activity
C2M21_RS14970	COG3106	COG3106 Predicted ATPase
C2M21_RS14980	COG1983	PspC domain protein
C2M21_RS14990	COG1842	Phage shock protein A
C2M21_RS14995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2M21_RS15005	COG1473	amidohydrolase
C2M21_RS15020	COG0702	epimerase
C2M21_RS15035	COG4171	peptide transport system, permease
C2M21_RS15050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2M21_RS15060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2M21_RS15065	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2M21_RS15065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2M21_RS15080	COG1349	DNA-binding transcription factor activity
C2M21_RS15090	COG0023	Translation Initiation Factor
C2M21_RS15100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2M21_RS15105	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2M21_RS15110	COG0671	phosphoesterase, PA-phosphatase related
C2M21_RS15120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2M21_RS15150	COG0616	signal peptide processing
C2M21_RS15160	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS15165	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C2M21_RS15195	COG0583	DNA-binding transcription factor activity
C2M21_RS15205	COG0009	L-threonylcarbamoyladenylate synthase
C2M21_RS15215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2M21_RS15220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2M21_RS15220	COG0512	Glutamine amidotransferase of anthranilate synthase
C2M21_RS15225	COG0135	phosphoribosylanthranilate isomerase activity
C2M21_RS15225	COG0134	indole-3-glycerol-phosphate synthase activity
C2M21_RS15260	COG4774	siderophore transport
C2M21_RS15270	COG3047	cAMP biosynthetic process
C2M21_RS15275	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2M21_RS15305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2M21_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS15315	COG1988	membrane-bound metal-dependent
C2M21_RS15320	COG1823	symporter activity
C2M21_RS15330	COG0753	catalase activity
C2M21_RS15340	COG1486	melibiose metabolic process
C2M21_RS15345	COG2169	Transcriptional regulator
C2M21_RS15345	COG1917	Cupin 2, conserved barrel domain protein
C2M21_RS15350	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2M21_RS15355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS15360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS15365	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2M21_RS15375	COG0322	excinuclease ABC activity
C2M21_RS15380	COG3678	ATP-independent chaperone mediated protein folding
C2M21_RS15390	COG3724	N-succinylarginine dihydrolase activity
C2M21_RS15400	COG3138	arginine N-succinyltransferase
C2M21_RS15410	COG0708	Exodeoxyribonuclease III
C2M21_RS15415	COG0398	Pfam SNARE associated Golgi protein
C2M21_RS15420	COG0398	Pfam SNARE associated Golgi protein
C2M21_RS15425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2M21_RS15430	COG4134	Bacterial extracellular solute-binding protein
C2M21_RS15435	COG4135	transport system, permease component
C2M21_RS15440	COG4136	ATPase activity
C2M21_RS15445	COG2897	thiosulfate sulfurtransferase activity
C2M21_RS15450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2M21_RS15455	COG0494	nUDIX hydrolase
C2M21_RS15460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2M21_RS15465	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS15465	COG3321	synthase
C2M21_RS15465	COG0604	alcohol dehydrogenase
C2M21_RS15470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2M21_RS15475	COG0709	Synthesizes selenophosphate from selenide and ATP
C2M21_RS15495	COG0778	Nitroreductase
C2M21_RS15500	COG0616	signal peptide processing
C2M21_RS15505	COG0252	asparaginase activity
C2M21_RS15510	COG1335	isochorismatase
C2M21_RS15525	COG3139	Protein of unknown function (DUF1315)
C2M21_RS15545	COG0656	L-ascorbic acid biosynthetic process
C2M21_RS15550	COG3713	MltA-interacting MipA family protein
C2M21_RS15555	COG2766	serine protein kinase
C2M21_RS15570	COG0386	Belongs to the glutathione peroxidase family
C2M21_RS15590	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS15595	COG0583	DNA-binding transcription factor activity
C2M21_RS15600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2M21_RS15605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2M21_RS15615	COG0859	PFAM glycosyl transferase family 9
C2M21_RS15620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2M21_RS15630	COG2207	Transcriptional regulator
C2M21_RS15635	COG2807	transmembrane transport
C2M21_RS15640	COG0504	CTP synthase activity
C2M21_RS15645	COG1683	Conserved Protein
C2M21_RS15650	COG3189	MarR family transcriptional regulator
C2M21_RS15655	COG3042	response to heat
C2M21_RS15660	COG2203	Gaf domain
C2M21_RS15660	COG2199	diguanylate cyclase activity
C2M21_RS15680	COG3182	Iron-regulated membrane protein
C2M21_RS15690	COG1560	Kdo2-lipid A biosynthetic process
C2M21_RS15705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2M21_RS15710	COG3706	GGDEF domain
C2M21_RS15715	COG0583	DNA-binding transcription factor activity
C2M21_RS15720	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2M21_RS15745	COG1294	oxidase, subunit
C2M21_RS15750	COG1271	oxidase subunit
C2M21_RS15755	COG3546	catalase activity
C2M21_RS15760	COG3685	Protein conserved in bacteria
C2M21_RS15765	COG3685	Protein conserved in bacteria
C2M21_RS15770	COG3729	General stress protein
C2M21_RS15775	COG1063	alcohol dehydrogenase
C2M21_RS15780	COG3813	Protein conserved in bacteria
C2M21_RS15800	COG0640	Transcriptional regulator
C2M21_RS15805	COG0538	isocitrate dehydrogenase activity
C2M21_RS15810	COG1187	pseudouridine synthase activity
C2M21_RS15830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2M21_RS15850	COG2205	protein histidine kinase activity
C2M21_RS15855	COG2850	peptidyl-arginine hydroxylation
C2M21_RS15875	COG1177	transmembrane transport
C2M21_RS15890	COG0318	PFAM AMP-dependent synthetase and ligase
C2M21_RS15895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2M21_RS15900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2M21_RS15905	COG0698	ribose 5-phosphate isomerase
C2M21_RS15920	COG3395	kinase activity
C2M21_RS15935	COG2390	Transcriptional regulator
C2M21_RS15945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2M21_RS15955	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2M21_RS15965	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2M21_RS15970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2M21_RS15975	COG1388	LysM domain
C2M21_RS15975	COG1376	ErfK ybiS ycfS ynhG family protein
C2M21_RS15985	COG1309	transcriptional regulator
C2M21_RS15995	COG3134	Outer membrane lipoprotein
C2M21_RS16000	COG1252	NADH dehydrogenase
C2M21_RS16025	COG5633	Lipoprotein
C2M21_RS16030	COG0537	adenosine 5'-monophosphoramidase activity
C2M21_RS16040	COG0084	hydrolase, TatD family'
C2M21_RS16045	COG0470	DNA polymerase III
C2M21_RS16055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2M21_RS16060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2M21_RS16065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2M21_RS16080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2M21_RS16100	COG1399	metal-binding, possibly nucleic acid-binding protein
C2M21_RS16120	COG1530	ribonuclease E activity
C2M21_RS16125	COG0583	DNA-binding transcription factor activity
C2M21_RS16130	COG2814	Major facilitator Superfamily
C2M21_RS16150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2M21_RS16200	COG1560	Kdo2-lipid A biosynthetic process
C2M21_RS16220	COG5645	(Lipo)protein
C2M21_RS16260	COG3381	protein complex oligomerization
C2M21_RS16290	COG0583	DNA-binding transcription factor activity
C2M21_RS16300	COG1335	isochorismatase
C2M21_RS16380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2M21_RS16385	COG1702	phosphate starvation-inducible protein PhoH
C2M21_RS16405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2M21_RS16415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2M21_RS16430	COG1309	transcriptional regulator
C2M21_RS16465	COG2233	PERMEase
C2M21_RS16480	COG3729	General stress protein
C2M21_RS16505	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS16520	COG0531	amino acid
C2M21_RS16530	COG0174	glutamine synthetase
C2M21_RS16535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2M21_RS16540	COG1396	sequence-specific DNA binding
C2M21_RS16540	COG1917	Cupin 2, conserved barrel domain protein
C2M21_RS16545	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS16550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2M21_RS16555	COG0583	DNA-binding transcription factor activity
C2M21_RS16560	COG0473	3-isopropylmalate dehydrogenase activity
C2M21_RS16565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2M21_RS16570	COG4638	Rieske (2fe-2S)
C2M21_RS16575	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS16580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2M21_RS16585	COG2200	EAL domain
C2M21_RS16600	COG0670	Belongs to the BI1 family
C2M21_RS16615	COG2207	Transcriptional regulator
C2M21_RS16620	COG1881	PFAM PEBP family protein
C2M21_RS16645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS16650	COG2274	protein secretion by the type I secretion system
C2M21_RS16665	COG1832	CoA-binding protein
C2M21_RS16675	COG0210	DNA helicase
C2M21_RS16680	COG3304	Inner membrane component domain
C2M21_RS16685	COG1289	transmembrane transporter activity
C2M21_RS16690	COG3070	regulator of competence-specific genes
C2M21_RS16715	COG1067	ATP-dependent peptidase activity
C2M21_RS16725	COG3130	regulation of translation
C2M21_RS16730	COG3009	Protein conserved in bacteria
C2M21_RS16735	COG3008	intermembrane lipid transfer
C2M21_RS16735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2M21_RS16740	COG2995	paraquat-inducible protein a
C2M21_RS16745	COG0488	(ABC) transporter
C2M21_RS16755	COG3217	Mosc domain protein beta barrel domain protein
C2M21_RS16755	COG0633	Ferredoxin
C2M21_RS16770	COG0431	NADPH-dependent FMN reductase
C2M21_RS16775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2M21_RS16780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2M21_RS16785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2M21_RS16795	COG0308	aminopeptidase N
C2M21_RS16805	COG1473	amidohydrolase
C2M21_RS16815	COG0814	amino acid
C2M21_RS16825	COG1522	sequence-specific DNA binding
C2M21_RS16835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2M21_RS16840	COG1448	Aminotransferase
C2M21_RS16845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2M21_RS16850	COG3108	Peptidase M15
C2M21_RS16855	COG2989	Protein conserved in bacteria
C2M21_RS16865	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2M21_RS16875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2M21_RS16880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2M21_RS16885	COG3173	Aminoglycoside phosphotransferase
C2M21_RS16900	COG3214	Protein conserved in bacteria
C2M21_RS16915	COG0658	competence protein
C2M21_RS16915	COG2333	competence protein COMEC
C2M21_RS16925	COG0539	negative regulation of cytoplasmic translation
C2M21_RS16945	COG2323	membrane
C2M21_RS16950	COG1944	ATP diphosphatase activity
C2M21_RS16955	COG2116	formate transmembrane transporter activity
C2M21_RS16960	COG1882	Formate acetyltransferase
C2M21_RS16965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2M21_RS16970	COG0477	Major facilitator Superfamily
C2M21_RS16980	COG3302	dmso reductase anchor subunit
C2M21_RS16985	COG0437	4 iron, 4 sulfur cluster binding
C2M21_RS16990	COG0243	molybdopterin cofactor binding
C2M21_RS17000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2M21_RS17010	COG1674	ftsk spoiiie
C2M21_RS17010	COG1178	ABC-type Fe3 transport system permease component
C2M21_RS17020	COG0492	ferredoxin-NADP+ reductase activity
C2M21_RS17025	COG4988	ABC transporter
C2M21_RS17030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2M21_RS17045	COG0542	response to heat
C2M21_RS17055	COG1278	Cold shock
C2M21_RS17065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS17070	COG3593	DNA synthesis involved in DNA repair
C2M21_RS17080	COG2431	L-lysine efflux transmembrane transporter activity
C2M21_RS17090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2M21_RS17100	COG0028	Belongs to the TPP enzyme family
C2M21_RS17105	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2M21_RS17110	COG0702	epimerase
C2M21_RS17115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2M21_RS17120	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2M21_RS17125	COG2203	Gaf domain
C2M21_RS17125	COG3706	GGDEF domain
C2M21_RS17125	COG5001	Diguanylate cyclase
C2M21_RS17125	COG4251	negative regulation of phosphorylation
C2M21_RS17140	COG1126	abc transporter atp-binding protein
C2M21_RS17145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS17150	COG4215	(ABC) transporter
C2M21_RS17155	COG4160	amino acid transport
C2M21_RS17160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS17165	COG5002	protein histidine kinase activity
C2M21_RS17170	COG0745	RESPONSE REGULATOR receiver
C2M21_RS17185	COG1177	transmembrane transport
C2M21_RS17190	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2M21_RS17195	COG3842	ATPase activity
C2M21_RS17200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2M21_RS17215	COG0778	Nitroreductase
C2M21_RS17240	COG3226	Transcriptional regulator
C2M21_RS17245	COG0738	Major facilitator superfamily
C2M21_RS17250	COG0561	phosphatase activity
C2M21_RS17255	COG2814	Major facilitator Superfamily
C2M21_RS17265	COG0671	phosphoesterase, PA-phosphatase related
C2M21_RS17270	COG1349	DNA-binding transcription factor activity
C2M21_RS17275	COG1686	Belongs to the peptidase S11 family
C2M21_RS17280	COG0625	glutathione transferase activity
C2M21_RS17285	COG2133	pyrroloquinoline quinone binding
C2M21_RS17295	COG2223	nitrite transmembrane transporter activity
C2M21_RS17320	COG0747	negative chemotaxis
C2M21_RS17335	COG0303	'Molybdopterin
C2M21_RS17340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2M21_RS17345	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2M21_RS17350	COG1882	Formate acetyltransferase
C2M21_RS17355	COG0561	phosphatase activity
C2M21_RS17365	COG1609	Transcriptional regulator
C2M21_RS17370	COG2271	Major facilitator Superfamily
C2M21_RS17380	COG0488	(ABC) transporter
C2M21_RS17385	COG2365	Tyrosine phosphatase family
C2M21_RS17390	COG1376	ErfK ybiS ycfS ynhG family protein
C2M21_RS17395	COG2188	Transcriptional regulator
C2M21_RS17400	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS17405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2M21_RS17420	COG2194	sulfuric ester hydrolase activity
C2M21_RS17425	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2M21_RS17440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS17445	COG0765	amino acid transport
C2M21_RS17450	COG1126	abc transporter atp-binding protein
C2M21_RS17455	COG0668	transmembrane transport
C2M21_RS17465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2M21_RS17475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2M21_RS17485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2M21_RS17490	COG1199	ATP-dependent helicase activity
C2M21_RS17495	COG0513	Belongs to the DEAD box helicase family
C2M21_RS17500	COG3958	Transketolase
C2M21_RS17505	COG3959	Transketolase, thiamine diphosphate binding domain
C2M21_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS17515	COG2271	Major facilitator Superfamily
C2M21_RS17520	COG0583	DNA-binding transcription factor activity
C2M21_RS17525	COG1309	transcriptional regulator
C2M21_RS17530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS17535	COG1131	(ABC) transporter
C2M21_RS17540	COG0842	Transport permease protein
C2M21_RS17545	COG0842	Transport permease protein
C2M21_RS17555	COG3568	Endonuclease Exonuclease Phosphatase
C2M21_RS17560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2M21_RS17565	COG0392	lysyltransferase activity
C2M21_RS17570	COG0670	Belongs to the BI1 family
C2M21_RS17575	COG0314	molybdopterin synthase activity
C2M21_RS17580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2M21_RS17590	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2M21_RS17615	COG0745	RESPONSE REGULATOR receiver
C2M21_RS17620	COG0642	Histidine kinase
C2M21_RS17660	COG2226	methyltransferase
C2M21_RS17675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2M21_RS17680	COG1881	PFAM PEBP family protein
C2M21_RS17720	COG4677	pectinesterase activity
C2M21_RS17735	COG0589	response to stress
C2M21_RS17740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS17770	COG0789	Transcriptional regulator
C2M21_RS17775	COG2200	EAL domain
C2M21_RS17800	COG0561	phosphatase activity
C2M21_RS17810	COG4149	molybdate abc transporter
C2M21_RS17815	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2M21_RS17825	COG3585	molybdate ion transport
C2M21_RS17825	COG2005	Transcriptional regulator
C2M21_RS17830	COG1119	ATPase activity
C2M21_RS17840	COG1085	galactose-1-phosphate uridylyltransferase
C2M21_RS17850	COG2017	converts alpha-aldose to the beta-anomer
C2M21_RS17860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2M21_RS17875	COG3201	nicotinamide mononucleotide transporter
C2M21_RS17880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2M21_RS17930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2M21_RS17935	COG2885	chlorophyll binding
C2M21_RS17945	COG3064	Membrane
C2M21_RS17950	COG0848	biopolymer transport protein
C2M21_RS17955	COG0811	peptide transport
C2M21_RS17960	COG0824	Thioesterase
C2M21_RS17965	COG3790	cyd operon protein YbgE
C2M21_RS17970	COG4890	Cyd operon protein YbgT
C2M21_RS17975	COG1294	oxidase, subunit
C2M21_RS17980	COG1271	oxidase subunit
C2M21_RS17990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2M21_RS18005	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2M21_RS18010	COG0567	Dehydrogenase, E1 component
C2M21_RS18015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2M21_RS18020	COG1053	succinate dehydrogenase
C2M21_RS18025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2M21_RS18030	COG2009	succinate dehydrogenase
C2M21_RS18065	COG1984	allophanate hydrolase subunit 2
C2M21_RS18070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2M21_RS18085	COG0415	Belongs to the DNA photolyase family
C2M21_RS18115	COG2205	protein histidine kinase activity
C2M21_RS18120	COG0745	RESPONSE REGULATOR receiver
C2M21_RS18130	COG0033	Phosphoglucomutase
C2M21_RS18140	COG0596	Alpha beta hydrolase
C2M21_RS18155	COG0735	belongs to the Fur family
C2M21_RS18195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2M21_RS18200	COG1846	Transcriptional regulator
C2M21_RS18200	COG1940	carbohydrate kinase activity
C2M21_RS18205	COG0647	UMP catabolic process
C2M21_RS18210	COG0367	asparagine synthase
C2M21_RS18255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2M21_RS18265	COG1702	phosphate starvation-inducible protein PhoH
C2M21_RS18290	COG0765	amino acid transport
C2M21_RS18295	COG0765	amino acid transport
C2M21_RS18300	COG1126	abc transporter atp-binding protein
C2M21_RS18315	COG2888	peptidyl-tyrosine sulfation
C2M21_RS18330	COG1466	dna polymerase III delta subunit
C2M21_RS18345	COG0799	negative regulation of ribosome biogenesis
C2M21_RS18355	COG0768	penicillin binding
C2M21_RS18360	COG0772	Belongs to the SEDS family
C2M21_RS18365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2M21_RS18370	COG1686	Belongs to the peptidase S11 family
C2M21_RS18385	COG0583	DNA-binding transcription factor activity
C2M21_RS18400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2M21_RS18420	COG3069	C4-dicarboxylate transmembrane transporter activity
C2M21_RS18425	COG3719	Belongs to the RNase T2 family
C2M21_RS18430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2M21_RS18450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2M21_RS18455	COG0583	DNA-binding transcription factor activity
C2M21_RS18460	COG3969	phosphoadenosine phosphosulfate
C2M21_RS18465	COG1475	DNA binding
C2M21_RS18470	COG0436	Aminotransferase
C2M21_RS18495	COG1129	ABC transporter
C2M21_RS18500	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS18505	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS18515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2M21_RS18530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2M21_RS18540	COG0402	S-adenosylhomocysteine deaminase activity
C2M21_RS18550	COG0483	inositol monophosphate 1-phosphatase activity
C2M21_RS18555	COG2271	Major facilitator Superfamily
C2M21_RS18590	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS18595	COG1129	ABC transporter
C2M21_RS18600	COG0371	Dehydrogenase
C2M21_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS18620	COG2879	small protein
C2M21_RS18625	COG1966	Carbon starvation protein
C2M21_RS18635	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS18640	COG1535	isochorismatase
C2M21_RS18640	COG3433	isochorismatase activity
C2M21_RS18645	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2M21_RS18650	COG1169	isochorismate synthase
C2M21_RS18655	COG4592	Periplasmic binding protein
C2M21_RS18665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS18670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS18675	COG1120	ATPase activity
C2M21_RS18680	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2M21_RS18680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2M21_RS18685	COG3251	PFAM MbtH domain protein
C2M21_RS18690	COG2382	esterase
C2M21_RS18700	COG4771	TonB-dependent receptor
C2M21_RS18705	COG2977	Belongs to the P-Pant transferase superfamily
C2M21_RS18710	COG3958	Transketolase
C2M21_RS18715	COG3959	Transketolase, thiamine diphosphate binding domain
C2M21_RS18725	COG2390	Transcriptional regulator
C2M21_RS18730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2M21_RS18735	COG1879	ABC-type sugar transport system periplasmic component
C2M21_RS18745	COG1129	ABC transporter
C2M21_RS18750	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS18760	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS18770	COG0583	DNA-binding transcription factor activity
C2M21_RS18775	COG0668	transmembrane transport
C2M21_RS18785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2M21_RS18810	COG0747	negative chemotaxis
C2M21_RS18815	COG0601	transmembrane transport
C2M21_RS18820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2M21_RS18825	COG0444	Belongs to the ABC transporter superfamily
C2M21_RS18830	COG4608	Belongs to the ABC transporter superfamily
C2M21_RS18835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2M21_RS18840	COG4221	oxidoreductase activity
C2M21_RS18850	COG4215	(ABC) transporter
C2M21_RS18855	COG0765	amino acid transport
C2M21_RS18860	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2M21_RS18875	COG0697	spore germination
C2M21_RS18885	COG3698	Phosphodiester glycosidase
C2M21_RS18930	COG2315	Protein conserved in bacteria
C2M21_RS18935	COG0778	Nitroreductase
C2M21_RS18965	COG0477	Major facilitator Superfamily
C2M21_RS18970	COG0668	transmembrane transport
C2M21_RS18975	COG1609	Transcriptional regulator
C2M21_RS18985	COG0673	inositol 2-dehydrogenase activity
C2M21_RS18995	COG2211	Major facilitator Superfamily
C2M21_RS19000	COG1113	amino acid transport
C2M21_RS19015	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS19020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2M21_RS19030	COG0531	amino acid
C2M21_RS19045	COG4680	protein conserved in bacteria
C2M21_RS19095	COG0667	Aldo Keto reductase
C2M21_RS19100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS19105	COG1473	amidohydrolase
C2M21_RS19125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS19130	COG1120	ATPase activity
C2M21_RS19135	COG1566	PFAM secretion protein HlyD family protein
C2M21_RS19180	COG4211	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS19185	COG1129	ABC transporter
C2M21_RS19200	COG0673	inositol 2-dehydrogenase activity
C2M21_RS19235	COG3104	oligopeptide transport
C2M21_RS19240	COG1982	Orn Lys Arg decarboxylase major
C2M21_RS19245	COG0531	amino acid
C2M21_RS19250	COG3710	Transcriptional regulator
C2M21_RS19260	COG1560	Kdo2-lipid A biosynthetic process
C2M21_RS19305	COG2501	S4 domain
C2M21_RS19315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2M21_RS19330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2M21_RS19335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2M21_RS19350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2M21_RS19355	COG4181	ATPase activity
C2M21_RS19360	COG2755	lipolytic protein G-D-S-L family
C2M21_RS19365	COG0300	oxidoreductase activity
C2M21_RS19370	COG3118	belongs to the thioredoxin family
C2M21_RS19380	COG0390	transport system, permease component
C2M21_RS19385	COG4619	ABC transporter
C2M21_RS19390	COG0330	HflC and HflK could
C2M21_RS19395	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2M21_RS19410	COG3735	TraB family
C2M21_RS19415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2M21_RS19425	COG2223	nitrite transmembrane transporter activity
C2M21_RS19430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2M21_RS19430	COG4651	solute:proton antiporter activity
C2M21_RS19435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2M21_RS19475	COG2832	Protein of unknown function (DUF454)
C2M21_RS19480	COG3923	Primosomal replication protein n
C2M21_RS19495	COG3264	Mechanosensitive ion channel
C2M21_RS19495	COG1196	nuclear chromosome segregation
C2M21_RS19500	COG1309	transcriptional regulator
C2M21_RS19505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS19510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2M21_RS19525	COG0110	maltose O-acetyltransferase activity
C2M21_RS19570	COG1874	Beta-galactosidase
C2M21_RS19575	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2M21_RS19580	COG3833	ABC-type maltose transport systems, permease component
C2M21_RS19585	COG1175	transmembrane transport
C2M21_RS19590	COG2182	Extracellular solute-binding protein
C2M21_RS19600	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2M21_RS19615	COG2364	Membrane
C2M21_RS19645	COG3695	enzyme binding
C2M21_RS19650	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2M21_RS19655	COG1946	Acyl-CoA thioesterase
C2M21_RS19660	COG0004	ammonium transporteR
C2M21_RS19665	COG0347	Belongs to the P(II) protein family
C2M21_RS19670	COG1132	(ABC) transporter
C2M21_RS19675	COG1132	(ABC) transporter
C2M21_RS19680	COG1522	sequence-specific DNA binding
C2M21_RS19695	COG4533	DNA binding
C2M21_RS19705	COG0824	Thioesterase
C2M21_RS19710	COG1555	photosystem II stabilization
C2M21_RS19715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2M21_RS19720	COG0776	regulation of translation
C2M21_RS19725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2M21_RS19755	COG0271	Belongs to the BolA IbaG family
C2M21_RS19760	COG3056	Lipoprotein
C2M21_RS19765	COG2223	nitrite transmembrane transporter activity
C2M21_RS19770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2M21_RS19775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2M21_RS19780	COG1845	cytochrome c oxidase, subunit III
C2M21_RS19785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2M21_RS19800	COG1414	Transcriptional regulator
C2M21_RS19805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2M21_RS19810	COG1053	succinate dehydrogenase
C2M21_RS19820	COG1053	succinate dehydrogenase
C2M21_RS19835	COG0673	inositol 2-dehydrogenase activity
C2M21_RS19840	COG2814	Major facilitator Superfamily
C2M21_RS19850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2M21_RS19855	COG0693	protein deglycase activity
C2M21_RS19875	COG0142	geranyltranstransferase activity
C2M21_RS19885	COG0667	Aldo Keto reductase
C2M21_RS19890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2M21_RS19910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2M21_RS19910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2M21_RS19920	COG4238	major outer membrane lipoprotein
C2M21_RS19940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2M21_RS19945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2M21_RS19950	COG1862	Preprotein translocase
C2M21_RS19970	COG0450	alkyl hydroperoxide reductase
C2M21_RS19975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS19990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2M21_RS20000	COG1228	amidohydrolase
C2M21_RS20010	COG1335	isochorismatase
C2M21_RS20015	COG0583	DNA-binding transcription factor activity
C2M21_RS20020	COG0366	Alpha amylase catalytic
C2M21_RS20045	COG0420	3'-5' exonuclease activity
C2M21_RS20050	COG0419	ATPase involved in DNA repair
C2M21_RS20055	COG1940	carbohydrate kinase activity
C2M21_RS20070	COG4126	flavin adenine dinucleotide binding
C2M21_RS20080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2M21_RS20085	COG3416	Protein conserved in bacteria
C2M21_RS20095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2M21_RS20105	COG1785	Belongs to the alkaline phosphatase family
C2M21_RS20145	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2M21_RS20150	COG1335	isochorismatase
C2M21_RS20155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2M21_RS20160	COG0113	porphobilinogen synthase activity
C2M21_RS20165	COG1943	Transposase
C2M21_RS20175	COG2175	clavaminate synthase activity
C2M21_RS20180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2M21_RS20185	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2M21_RS20190	COG4521	taurine ABC transporter
C2M21_RS20195	COG2040	homocysteine
C2M21_RS20200	COG0833	amino acid
C2M21_RS20210	COG4303	Ethanolamine ammonia lyase large subunit
C2M21_RS20215	COG4302	ethanolamine ammonia-lyase activity
C2M21_RS20255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS20260	COG1126	abc transporter atp-binding protein
C2M21_RS20265	COG4597	amino acid ABC transporter
C2M21_RS20270	COG0765	amino acid transport
C2M21_RS20285	COG3188	usher protein
C2M21_RS20310	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2M21_RS20320	COG3639	organic phosphonate transmembrane transporter activity
C2M21_RS20355	COG0791	NLP P60 protein
C2M21_RS20385	COG4581	dead DEAH box helicase
C2M21_RS20405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2M21_RS20410	COG0022	dehydrogenase e1 component
C2M21_RS20415	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2M21_RS20420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2M21_RS20445	COG1070	Carbohydrate kinase
C2M21_RS20450	COG1028	Short-chain dehydrogenase reductase Sdr
C2M21_RS20455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2M21_RS20460	COG3775	system Galactitol-specific IIC component
C2M21_RS20465	COG0625	glutathione transferase activity
C2M21_RS20470	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2M21_RS20490	COG0579	oxidoreductase
C2M21_RS20495	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS20500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2M21_RS20505	COG1113	amino acid transport
C2M21_RS20510	COG1802	Transcriptional regulator
C2M21_RS20530	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2M21_RS20535	COG0454	-acetyltransferase
C2M21_RS20550	COG2991	Protein conserved in bacteria
C2M21_RS20565	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2M21_RS20570	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2M21_RS20590	COG3034	peptidoglycan biosynthetic process
C2M21_RS20595	COG0121	glutamine amidotransferase
C2M21_RS20605	COG1960	acyl-CoA dehydrogenase activity
C2M21_RS20610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2M21_RS20620	COG0583	DNA-binding transcription factor activity
C2M21_RS20630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2M21_RS20640	COG2226	methyltransferase
C2M21_RS20650	COG1388	LysM domain
C2M21_RS20650	COG0741	lytic transglycosylase activity
C2M21_RS20655	COG2226	methyltransferase
C2M21_RS20665	COG2814	Major facilitator Superfamily
C2M21_RS20670	COG0583	DNA-binding transcription factor activity
C2M21_RS20675	COG0656	L-ascorbic acid biosynthetic process
C2M21_RS20710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2M21_RS20720	COG2011	ABC-type metal ion transport system permease component
C2M21_RS20725	COG1464	Belongs to the NlpA lipoprotein family
C2M21_RS20735	COG1720	tRNA m6t6A37 methyltransferase activity
C2M21_RS20745	COG0791	NLP P60 protein
C2M21_RS20750	COG3015	lipoprotein NlpE involved in copper resistance
C2M21_RS20755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2M21_RS20770	COG4568	rho-dependent transcription termination
C2M21_RS20780	COG0346	lactoylglutathione lyase activity
C2M21_RS20785	COG1982	Orn Lys Arg decarboxylase major
C2M21_RS20795	COG0587	DNA-directed DNA polymerase activity
C2M21_RS20825	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2M21_RS20835	COG0750	zinc metalloprotease
C2M21_RS20840	COG0575	Belongs to the CDS family
C2M21_RS20855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2M21_RS20880	COG0024	Methionine aminopeptidase
C2M21_RS20885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2M21_RS20900	COG3835	regulator
C2M21_RS20905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2M21_RS20925	COG2860	membrane
C2M21_RS20945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2M21_RS20950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2M21_RS20955	COG1120	ATPase activity
C2M21_RS20960	COG4774	siderophore transport
C2M21_RS20965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2M21_RS21050	COG1643	Atp-dependent helicase
C2M21_RS21055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2M21_RS21075	COG0617	tRNA 3'-terminal CCA addition
C2M21_RS21080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2M21_RS21100	COG0726	polysaccharide deacetylase
C2M21_RS21105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS21110	COG0842	Transport permease protein
C2M21_RS21115	COG1131	(ABC) transporter
C2M21_RS21120	COG0288	reversible hydration of carbon dioxide
C2M21_RS21130	COG4993	Dehydrogenase
C2M21_RS21135	COG2132	Multicopper oxidase
C2M21_RS21180	COG3064	Membrane
C2M21_RS21195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2M21_RS21200	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2M21_RS21205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2M21_RS21210	COG2186	Transcriptional regulator
C2M21_RS21215	COG1113	amino acid transport
C2M21_RS21220	COG2211	Major facilitator Superfamily
C2M21_RS21225	COG3940	Belongs to the glycosyl hydrolase 43 family
C2M21_RS21230	COG3725	Membrane protein required for beta-lactamase induction
C2M21_RS21235	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2M21_RS21245	COG4969	Belongs to the N-Me-Phe pilin family
C2M21_RS21250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2M21_RS21255	COG1459	type II secretion system
C2M21_RS21280	COG0494	nUDIX hydrolase
C2M21_RS21300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2M21_RS21305	COG0849	cell division
C2M21_RS21330	COG0772	Belongs to the SEDS family
C2M21_RS21345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2M21_RS21350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2M21_RS21355	COG0768	penicillin binding
C2M21_RS21375	COG1609	Transcriptional regulator
C2M21_RS21385	COG0028	Belongs to the TPP enzyme family
C2M21_RS21435	COG0738	Major facilitator superfamily
C2M21_RS21445	COG0583	DNA-binding transcription factor activity
C2M21_RS21450	COG2271	Major facilitator Superfamily
C2M21_RS21455	COG2814	Major facilitator Superfamily
C2M21_RS21475	COG1178	ABC-type Fe3 transport system permease component
C2M21_RS21485	COG0586	Pfam SNARE associated Golgi protein
C2M21_RS21505	COG0235	Class ii aldolase
C2M21_RS21510	COG0417	DNA replication proofreading
C2M21_RS21520	COG0564	pseudouridine synthase activity
C2M21_RS21535	COG3493	citrate carrier protein
C2M21_RS21550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2M21_RS21555	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2M21_RS21565	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2M21_RS21615	COG0505	Belongs to the CarA family
C2M21_RS21625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2M21_RS21650	COG1047	Peptidyl-prolyl cis-trans
C2M21_RS21665	COG0196	riboflavin kinase activity
C2M21_RS21680	COG0583	DNA-binding transcription factor activity
C2M21_RS21705	COG4735	regulation of single-species biofilm formation
C2M21_RS21710	COG1584	GPR1 FUN34 yaaH family protein
C2M21_RS21715	COG0477	Major facilitator Superfamily
C2M21_RS21720	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2M21_RS21725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2M21_RS21730	COG1115	amino acid carrier protein
C2M21_RS21745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2M21_RS21755	COG0460	homoserine dehydrogenase
C2M21_RS21755	COG0527	aspartate kinase activity
C2M21_RS21765	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2M21_RS21775	COG0745	RESPONSE REGULATOR receiver
C2M21_RS21780	COG4452	Inner membrane protein CreD
C2M21_RS21785	COG2205	protein histidine kinase activity
C2M21_RS21790	COG0745	RESPONSE REGULATOR receiver
C2M21_RS21795	COG3045	CreA protein
C2M21_RS21800	COG3708	Transcriptional regulator
C2M21_RS21800	COG2207	Transcriptional regulator
C2M21_RS21820	COG0741	lytic transglycosylase activity
C2M21_RS21825	COG0488	(ABC) transporter
C2M21_RS21835	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2M21_RS21840	COG0560	Phosphoserine phosphatase
C2M21_RS21850	COG3726	membrane protein affecting hemolysin expression
C2M21_RS21880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2M21_RS21885	COG0084	hydrolase, TatD family'
C2M21_RS21890	COG4667	esterase of the alpha-beta hydrolase superfamily
C2M21_RS21900	COG2823	Periplasmic or secreted lipoprotein
C2M21_RS21910	COG1011	Hydrolase
C2M21_RS21915	COG0456	acetyltransferase
C2M21_RS21920	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2M21_RS21950	COG3706	GGDEF domain
C2M21_RS21955	COG4114	ferric iron reductase
C2M21_RS21960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS21960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS21965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2M21_RS21970	COG2197	response regulator
C2M21_RS21975	COG2197	response regulator
C2M21_RS21995	COG2966	Psort location CytoplasmicMembrane, score
C2M21_RS22010	COG1484	DNA-dependent DNA replication
C2M21_RS22025	COG5464	transposase or invertase
C2M21_RS22035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2M21_RS22040	COG3716	PTS system mannose fructose sorbose family IID component
C2M21_RS22045	COG3715	PTS system
C2M21_RS22060	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2M21_RS22060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2M21_RS22065	COG1214	PFAM Peptidase M22, glycoprotease
C2M21_RS22065	COG0456	acetyltransferase
C2M21_RS22075	COG1737	Transcriptional regulator
C2M21_RS22080	COG0800	Aldolase
C2M21_RS22085	COG3734	2-keto-3-deoxy-galactonokinase
C2M21_RS22100	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2M21_RS22130	COG1846	Transcriptional regulator
C2M21_RS22135	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2M21_RS22145	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS22150	COG3384	dioxygenase
C2M21_RS22160	COG3971	2-oxopent-4-enoate hydratase activity
C2M21_RS22180	COG2368	4-hydroxyphenylacetate
C2M21_RS22185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2M21_RS22200	COG1966	Carbon starvation protein
C2M21_RS22205	COG2879	small protein
C2M21_RS22210	COG0523	cobalamin synthesis protein
C2M21_RS22220	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS22225	COG5464	transposase or invertase
C2M21_RS22230	COG2207	Transcriptional regulator
C2M21_RS22230	COG1917	Cupin 2, conserved barrel domain protein
C2M21_RS22240	COG2733	membrane
C2M21_RS22255	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2M21_RS22260	COG1924	4 iron, 4 sulfur cluster binding
C2M21_RS22275	COG1566	PFAM secretion protein HlyD family protein
C2M21_RS22285	COG5457	Domain of unknown function (DUF1127)
C2M21_RS22290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2M21_RS22300	COG0583	DNA-binding transcription factor activity
C2M21_RS22305	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2M21_RS22315	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS22320	COG1129	ABC transporter
C2M21_RS22325	COG1879	ABC-type sugar transport system periplasmic component
C2M21_RS22335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS22340	COG1129	ABC transporter
C2M21_RS22340	COG0842	Transport permease protein
C2M21_RS22345	COG0842	Transport permease protein
C2M21_RS22375	COG2850	peptidyl-arginine hydroxylation
C2M21_RS22390	COG5002	protein histidine kinase activity
C2M21_RS22395	COG0745	RESPONSE REGULATOR receiver
C2M21_RS22405	COG1538	Outer membrane efflux protein
C2M21_RS22410	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS22415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2M21_RS22420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2M21_RS22430	COG3040	lipid binding
C2M21_RS22435	COG0789	Transcriptional regulator
C2M21_RS22445	COG0300	oxidoreductase activity
C2M21_RS22460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2M21_RS22480	COG3272	Protein of unknown function (DUF1722)
C2M21_RS22485	COG4580	involved in the transport of maltose and maltodextrins
C2M21_RS22490	COG2115	Belongs to the xylose isomerase family
C2M21_RS22495	COG2211	Major facilitator Superfamily
C2M21_RS22500	COG3507	Belongs to the glycosyl hydrolase 43 family
C2M21_RS22520	COG1216	Glycosyl transferase, family 2
C2M21_RS22570	COG2894	cell division
C2M21_RS22580	COG0305	Participates in initiation and elongation during chromosome replication
C2M21_RS22600	COG3468	outer membrane autotransporter barrel domain protein
C2M21_RS22620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2M21_RS22625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2M21_RS22770	COG3423	Transcriptional regulator
C2M21_RS22775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2M21_RS22790	COG0641	radical SAM
C2M21_RS22795	COG0730	response to heat
C2M21_RS22800	COG3119	arylsulfatase activity
C2M21_RS22805	COG2211	Major facilitator Superfamily
C2M21_RS22855	COG1401	restriction endodeoxyribonuclease activity
C2M21_RS22890	COG0288	reversible hydration of carbon dioxide
C2M21_RS22895	COG0659	secondary active sulfate transmembrane transporter activity
C2M21_RS22900	COG1064	alcohol dehydrogenase
C2M21_RS22905	COG1175	transmembrane transport
C2M21_RS22910	COG0395	ABC-type sugar transport system, permease component
C2M21_RS22915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2M21_RS22920	COG3842	ATPase activity
C2M21_RS22935	COG1082	Xylose isomerase domain protein TIM barrel
C2M21_RS22945	COG3962	Belongs to the TPP enzyme family
C2M21_RS22950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2M21_RS22955	COG1737	Transcriptional regulator
C2M21_RS22955	COG0837	glucose binding
C2M21_RS22965	COG3718	enzyme involved in inositol metabolism
C2M21_RS22980	COG0433	COG0433 Predicted ATPase
C2M21_RS22985	COG0795	lipopolysaccharide-transporting ATPase activity
C2M21_RS22990	COG0795	lipopolysaccharide-transporting ATPase activity
C2M21_RS23005	COG2927	DNA polymerase III (CHI subunit)
C2M21_RS23010	COG0525	valine-tRNA ligase activity
C2M21_RS23035	COG2731	YhcH YjgK YiaL family protein
C2M21_RS23080	COG1263	PTS System
C2M21_RS23080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2M21_RS23085	COG0366	Alpha amylase catalytic
C2M21_RS23090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2M21_RS23095	COG1486	melibiose metabolic process
C2M21_RS23115	COG0602	queuosine metabolic process
C2M21_RS23120	COG2026	Addiction module toxin, RelE StbE family
C2M21_RS23125	COG3077	Addiction module antitoxin, RelB DinJ family
C2M21_RS23130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2M21_RS23130	COG3711	transcriptional antiterminator
C2M21_RS23135	COG2706	6-phosphogluconolactonase activity
C2M21_RS23150	COG3964	amidohydrolase
C2M21_RS23185	COG0312	modulator of DNA gyrase
C2M21_RS23205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2M21_RS23215	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS23220	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS23225	COG1129	ABC transporter
C2M21_RS23230	COG1879	ABC-type sugar transport system periplasmic component
C2M21_RS23245	COG2105	PFAM AIG2 family protein
C2M21_RS23250	COG2911	Protein conserved in bacteria
C2M21_RS23255	COG0729	surface antigen
C2M21_RS23265	COG1253	flavin adenine dinucleotide binding
C2M21_RS23280	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2M21_RS23295	COG1733	regulation of RNA biosynthetic process
C2M21_RS23300	COG0702	epimerase
C2M21_RS23310	COG0697	spore germination
C2M21_RS23320	COG1113	amino acid transport
C2M21_RS23325	COG0545	Peptidyl-prolyl cis-trans isomerase
C2M21_RS23330	COG3061	Opacity-associated protein A
C2M21_RS23340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2M21_RS23345	COG2965	DNA replication, synthesis of RNA primer
C2M21_RS23405	COG1073	alpha beta
C2M21_RS23410	COG3650	response to hydrogen peroxide
C2M21_RS23420	COG1960	acyl-CoA dehydrogenase activity
C2M21_RS23425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2M21_RS23430	COG0557	exoribonuclease II activity
C2M21_RS23445	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2M21_RS23460	COG0330	HflC and HflK could
C2M21_RS23465	COG0330	HflC and HflK could
C2M21_RS23470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2M21_RS23490	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2M21_RS23495	COG0802	atpase or kinase
C2M21_RS23500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2M21_RS23500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2M21_RS23505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2M21_RS23530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS23555	COG1511	domain protein
C2M21_RS23555	COG3264	Mechanosensitive ion channel
C2M21_RS23570	COG1053	succinate dehydrogenase
C2M21_RS23575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2M21_RS23595	COG2076	Multidrug Resistance protein
C2M21_RS23600	COG5510	response to toxic substance
C2M21_RS23615	COG1509	lysine 2,3-aminomutase activity
C2M21_RS23680	COG0531	amino acid
C2M21_RS23685	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2M21_RS23695	COG1027	Aspartate ammonia-lyase
C2M21_RS23700	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2M21_RS23715	COG1309	transcriptional regulator
C2M21_RS23750	COG0457	Tetratricopeptide repeat
C2M21_RS23755	COG1649	PFAM Uncharacterised BCR, COG1649
C2M21_RS23755	COG0726	polysaccharide deacetylase
C2M21_RS23760	COG1215	transferase activity, transferring glycosyl groups
C2M21_RS23780	COG0861	Integral membrane protein TerC family
C2M21_RS23810	COG1486	melibiose metabolic process
C2M21_RS23820	COG2169	Transcriptional regulator
C2M21_RS23835	COG2824	Alkylphosphonate utilization operon protein PhnA
C2M21_RS23840	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C2M21_RS23845	COG2188	Transcriptional regulator
C2M21_RS23850	COG3624	Phosphonate C-P lyase system protein PhnG
C2M21_RS23855	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2M21_RS23860	COG3626	phosphonate metabolism
C2M21_RS23865	COG3627	carbon phosphorus lyase activity
C2M21_RS23870	COG4107	phosphonate C-P lyase system protein PhnK
C2M21_RS23875	COG4778	phosphonate C-P lyase system protein PhnL
C2M21_RS23880	COG3454	Phosphonate metabolism
C2M21_RS23890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2M21_RS23900	COG4191	Histidine kinase
C2M21_RS23900	COG0784	Response regulator, receiver
C2M21_RS23905	COG1129	ABC transporter
C2M21_RS23910	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS23950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2M21_RS23955	COG1301	dicarboxylic acid transport
C2M21_RS23965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2M21_RS23975	COG3162	membrane
C2M21_RS24005	COG3539	Fimbrial protein
C2M21_RS24010	COG1346	cytolysis
C2M21_RS24015	COG1380	Effector of murein hydrolase LrgA
C2M21_RS24020	COG0583	DNA-binding transcription factor activity
C2M21_RS24025	COG0025	NhaP-type Na H and K H
C2M21_RS24030	COG2252	PERMEase
C2M21_RS24035	COG0625	glutathione transferase activity
C2M21_RS24040	COG0789	Transcriptional regulator
C2M21_RS24050	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2M21_RS24085	COG1234	tRNA 3'-trailer cleavage
C2M21_RS24090	COG1609	Transcriptional regulator
C2M21_RS24095	COG0483	inositol monophosphate 1-phosphatase activity
C2M21_RS24110	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2M21_RS24130	COG4771	TonB-dependent receptor
C2M21_RS24135	COG0741	lytic transglycosylase activity
C2M21_RS24155	COG2315	Protein conserved in bacteria
C2M21_RS24160	COG0432	Pfam Uncharacterised protein family UPF0047
C2M21_RS24175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2M21_RS24180	COG0305	Participates in initiation and elongation during chromosome replication
C2M21_RS24195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2M21_RS24205	COG0735	belongs to the Fur family
C2M21_RS24210	COG3237	CsbD-like
C2M21_RS24215	COG0534	Mate efflux family protein
C2M21_RS24225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2M21_RS24300	COG0251	oxidation-reduction process
C2M21_RS24310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2M21_RS24330	COG0527	aspartate kinase activity
C2M21_RS24390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2M21_RS24400	COG0456	acetyltransferase
C2M21_RS24430	COG0151	Belongs to the GarS family
C2M21_RS24440	COG4191	Histidine kinase
C2M21_RS24445	COG3678	ATP-independent chaperone mediated protein folding
C2M21_RS24480	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2M21_RS24495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2M21_RS24500	COG2104	thiamine diphosphate biosynthetic process
C2M21_RS24515	COG3706	GGDEF domain
C2M21_RS24525	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2M21_RS24530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2M21_RS24565	COG0250	Participates in transcription elongation, termination and antitermination
C2M21_RS24615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2M21_RS24645	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2M21_RS24655	COG1739	Uncharacterized protein family UPF0029
C2M21_RS24700	COG0805	protein transport
C2M21_RS24720	COG3165	ubiquinone biosynthetic process from chorismate
C2M21_RS24750	COG0583	DNA-binding transcription factor activity
C2M21_RS24755	COG0697	spore germination
C2M21_RS24760	COG0561	phosphatase activity
C2M21_RS24765	COG2267	carboxylic ester hydrolase activity
C2M21_RS24770	COG1280	lysine exporter protein (LysE YggA)
C2M21_RS24780	COG1280	lysine exporter protein (LysE YggA)
C2M21_RS24815	COG0210	DNA helicase
C2M21_RS24820	COG1011	Hydrolase
C2M21_RS24850	COG3072	Adenylate cyclase
C2M21_RS24865	COG2959	enzyme of heme biosynthesis
C2M21_RS24870	COG3071	HemY protein
C2M21_RS24915	COG2244	polysaccharide biosynthetic process
C2M21_RS24920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2M21_RS24925	COG0456	acetyltransferase
C2M21_RS24930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2M21_RS24935	COG1088	dTDP-glucose 4,6-dehydratase activity
C2M21_RS24940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2M21_RS24945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2M21_RS24955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2M21_RS24960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2M21_RS24970	COG3118	belongs to the thioredoxin family
C2M21_RS25000	COG1811	Na channel or pump
C2M21_RS25010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2M21_RS25015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2M21_RS25025	COG0583	DNA-binding transcription factor activity
C2M21_RS25030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2M21_RS25045	COG3978	acetolactate synthase activity
C2M21_RS25065	COG3085	chromosome segregation
C2M21_RS25140	COG0583	DNA-binding transcription factor activity
C2M21_RS25165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2M21_RS25180	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2M21_RS25185	COG2207	Transcriptional regulator
C2M21_RS25195	COG0371	Dehydrogenase
C2M21_RS25200	COG0697	spore germination
C2M21_RS25210	COG0583	DNA-binding transcription factor activity
C2M21_RS25220	COG0737	Belongs to the 5'-nucleotidase family
C2M21_RS25230	COG0460	homoserine dehydrogenase
C2M21_RS25230	COG0527	aspartate kinase activity
C2M21_RS25235	COG0626	cystathionine gamma-synthase activity
C2M21_RS25250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2M21_RS25255	COG1609	Transcriptional regulator
C2M21_RS25260	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2M21_RS25275	COG1575	Belongs to the MenA family. Type 1 subfamily
C2M21_RS25295	COG3678	ATP-independent chaperone mediated protein folding
C2M21_RS25300	COG0745	RESPONSE REGULATOR receiver
C2M21_RS25305	COG2205	protein histidine kinase activity
C2M21_RS25310	COG2258	MOSC domain
C2M21_RS25315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2M21_RS25360	COG1129	ABC transporter
C2M21_RS25365	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS25370	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS25375	COG1454	alcohol dehydrogenase
C2M21_RS25385	COG2211	Major facilitator Superfamily
C2M21_RS25425	COG3383	formate dehydrogenase (NAD+) activity
C2M21_RS25425	COG0243	molybdopterin cofactor binding
C2M21_RS25430	COG0243	molybdopterin cofactor binding
C2M21_RS25430	COG3383	formate dehydrogenase (NAD+) activity
C2M21_RS25435	COG0437	4 iron, 4 sulfur cluster binding
C2M21_RS25440	COG2864	formate dehydrogenase
C2M21_RS25455	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2M21_RS25465	COG0456	acetyltransferase
C2M21_RS25480	COG1011	Hydrolase
C2M21_RS25495	COG3852	Histidine kinase
C2M21_RS25505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2M21_RS25535	COG0204	Acyl-transferase
C2M21_RS25545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2M21_RS25550	COG3084	Protein conserved in bacteria
C2M21_RS25560	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2M21_RS25590	COG2186	Transcriptional regulator
C2M21_RS25595	COG0477	Major facilitator Superfamily
C2M21_RS25600	COG1609	Transcriptional regulator
C2M21_RS25605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2M21_RS25615	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2M21_RS25620	COG1129	ABC transporter
C2M21_RS25650	COG1522	sequence-specific DNA binding
C2M21_RS25655	COG0716	FMN binding
C2M21_RS25670	COG3312	ion transport
C2M21_RS25725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2M21_RS25730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2M21_RS25735	COG0573	inorganic phosphate transmembrane transporter activity
C2M21_RS25740	COG0581	inorganic phosphate transmembrane transporter activity
C2M21_RS25745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2M21_RS25750	COG0704	Plays a role in the regulation of phosphate uptake
C2M21_RS25765	COG2382	esterase
C2M21_RS25770	COG0363	glucosamine-6-phosphate deaminase activity
C2M21_RS25775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2M21_RS25785	COG2252	PERMEase
C2M21_RS25790	COG0431	NADPH-dependent FMN reductase
C2M21_RS25795	COG2091	lysine biosynthetic process via aminoadipic acid
C2M21_RS25825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2M21_RS26070	COG1475	DNA binding
C2M21_RS26235	COG0702	epimerase
C2M21_RS26240	COG1733	regulation of RNA biosynthetic process
C2M21_RS26250	COG0778	Nitroreductase
C2M21_RS26265	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS26280	COG2223	nitrite transmembrane transporter activity
C2M21_RS26290	COG2723	6-phospho-beta-galactosidase activity
C2M21_RS26295	COG0583	DNA-binding transcription factor activity
C2M21_RS26300	COG2814	Major facilitator Superfamily
C2M21_RS26375	COG4215	(ABC) transporter
C2M21_RS26385	COG1126	abc transporter atp-binding protein
C2M21_RS26400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2M21_RS26445	COG1169	isochorismate synthase
C2M21_RS26450	COG2814	Major facilitator Superfamily
C2M21_RS26455	COG1132	(ABC) transporter
C2M21_RS26470	COG2226	methyltransferase
C2M21_RS26470	COG3433	isochorismatase activity
C2M21_RS26470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2M21_RS26490	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2M21_RS26495	COG4771	TonB-dependent receptor
C2M21_RS26515	COG2423	ornithine cyclodeaminase activity
C2M21_RS26525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2M21_RS26530	COG3138	arginine N-succinyltransferase
C2M21_RS26535	COG1012	belongs to the aldehyde dehydrogenase family
C2M21_RS26540	COG2988	succinylglutamate desuccinylase activity
C2M21_RS26545	COG4215	(ABC) transporter
C2M21_RS26550	COG4160	amino acid transport
C2M21_RS26555	COG4598	ABC transporter
C2M21_RS26560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2M21_RS26565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2M21_RS26675	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2M21_RS26695	COG0675	Transposase, IS605 OrfB family