locus-tag	class	description
I6K35_RS00050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS00055	COG1842	Phage shock protein A
I6K35_RS00085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS00090	COG1842	Phage shock protein A
I6K35_RS00100	COG1983	PspC domain protein
I6K35_RS00215	COG3621	Patatin-like phospholipase
I6K35_RS00260	COG3344	reverse transcriptase
I6K35_RS00275	COG1192	Involved in chromosome partitioning
I6K35_RS00350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS00355	COG1842	Phage shock protein A
I6K35_RS00365	COG1983	PspC domain protein
I6K35_RS00455	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS00460	COG1842	Phage shock protein A
I6K35_RS00470	COG1983	PspC domain protein
I6K35_RS00535	COG1842	Phage shock protein A
I6K35_RS00565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS00570	COG1842	Phage shock protein A
I6K35_RS00580	COG1983	PspC domain protein
I6K35_RS00640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS00705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS00710	COG1842	Phage shock protein A
I6K35_RS00785	COG3547	Transposase (IS116 IS110 IS902 family)
I6K35_RS00850	COG3436	PFAM IS66 Orf2 family protein
I6K35_RS00855	COG4372	Transposase
I6K35_RS00870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K35_RS00880	COG1136	(ABC) transporter
I6K35_RS00880	COG0577	efflux transmembrane transporter activity
I6K35_RS01050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS01080	COG0745	RESPONSE REGULATOR receiver
I6K35_RS01085	COG0745	RESPONSE REGULATOR receiver
I6K35_RS01100	COG0671	phosphoesterase, PA-phosphatase related
I6K35_RS01125	COG2223	nitrite transmembrane transporter activity
I6K35_RS01155	COG3436	PFAM IS66 Orf2 family protein
I6K35_RS01160	COG1120	ATPase activity
I6K35_RS01165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS01170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS01175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K35_RS01180	COG4772	TonB-dependent receptor
I6K35_RS01185	COG3712	iron ion homeostasis
I6K35_RS01190	COG1595	DNA-templated transcription, initiation
I6K35_RS01225	COG2223	nitrite transmembrane transporter activity
I6K35_RS01235	COG1609	Transcriptional regulator
I6K35_RS01245	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
I6K35_RS01380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6K35_RS01385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K35_RS01390	COG0384	phenazine biosynthesis protein PhzF
I6K35_RS01400	COG0251	oxidation-reduction process
I6K35_RS01405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K35_RS01420	COG0673	inositol 2-dehydrogenase activity
I6K35_RS01425	COG1082	Xylose isomerase domain protein TIM barrel
I6K35_RS01430	COG2814	Major facilitator Superfamily
I6K35_RS01435	COG1609	Transcriptional regulator
I6K35_RS01450	COG2801	Transposase and inactivated derivatives
I6K35_RS01475	COG2944	sequence-specific DNA binding
I6K35_RS01635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K35_RS01640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6K35_RS01670	COG2986	histidine ammonia-lyase
I6K35_RS01680	COG2188	Transcriptional regulator
I6K35_RS01685	COG0402	S-adenosylhomocysteine deaminase activity
I6K35_RS01700	COG5499	transcription regulator containing HTH domain
I6K35_RS01705	COG4680	protein conserved in bacteria
I6K35_RS01720	COG3436	PFAM IS66 Orf2 family protein
I6K35_RS01725	COG4372	Transposase
I6K35_RS01755	COG0583	DNA-binding transcription factor activity
I6K35_RS01765	COG0765	amino acid transport
I6K35_RS01770	COG0765	amino acid transport
I6K35_RS01775	COG4598	ABC transporter
I6K35_RS01785	COG3039	Transposase
I6K35_RS01800	COG5654	RES domain protein
I6K35_RS01805	COG5642	Protein of unknown function (DUF2384)
I6K35_RS01835	COG3436	PFAM IS66 Orf2 family protein
I6K35_RS01855	COG0501	Belongs to the peptidase M48B family
I6K35_RS01865	COG3706	GGDEF domain
I6K35_RS01875	COG0542	response to heat
I6K35_RS01880	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K35_RS01925	COG3436	PFAM IS66 Orf2 family protein
I6K35_RS01945	COG2205	protein histidine kinase activity
I6K35_RS01950	COG0745	RESPONSE REGULATOR receiver
I6K35_RS01955	COG1276	copper resistance
I6K35_RS01960	COG2372	response to copper ion
I6K35_RS01965	COG3667	copper resistance
I6K35_RS01970	COG2132	Multicopper oxidase
I6K35_RS01980	COG0739	heme binding
I6K35_RS02010	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS02020	COG2197	response regulator
I6K35_RS02035	COG2197	response regulator
I6K35_RS02070	COG3012	SEC-C Motif Domain Protein
I6K35_RS02070	COG3318	Belongs to the UPF0149 family
I6K35_RS02075	COG0814	amino acid
I6K35_RS02085	COG1528	Iron-storage protein
I6K35_RS02100	COG0477	Major facilitator Superfamily
I6K35_RS02110	COG2211	Major facilitator Superfamily
I6K35_RS02120	COG1528	Iron-storage protein
I6K35_RS02130	COG1879	ABC-type sugar transport system periplasmic component
I6K35_RS02140	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS02165	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K35_RS02175	COG3102	Protein conserved in bacteria
I6K35_RS02195	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K35_RS02200	COG1801	Protein of unknown function DUF72
I6K35_RS02205	COG1335	isochorismatase
I6K35_RS02215	COG0494	nUDIX hydrolase
I6K35_RS02240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K35_RS02250	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K35_RS02255	COG0739	heme binding
I6K35_RS02260	COG1560	Kdo2-lipid A biosynthetic process
I6K35_RS02270	COG1737	Transcriptional regulator
I6K35_RS02280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K35_RS02285	COG0129	dihydroxy-acid dehydratase activity
I6K35_RS02290	COG0800	Aldolase
I6K35_RS02300	COG3141	response to X-ray
I6K35_RS02305	COG2979	Protein of unknown function (DUF533)
I6K35_RS02310	COG1770	oligopeptidase
I6K35_RS02315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K35_RS02325	COG2372	response to copper ion
I6K35_RS02330	COG1276	copper resistance
I6K35_RS02345	COG2990	Protein conserved in bacteria
I6K35_RS02370	COG3008	intermembrane lipid transfer
I6K35_RS02375	COG2995	paraquat-inducible protein a
I6K35_RS02380	COG1956	GAF domain-containing protein
I6K35_RS02400	COG2814	Major facilitator Superfamily
I6K35_RS02405	COG1414	Transcriptional regulator
I6K35_RS02435	COG0768	penicillin binding
I6K35_RS02440	COG2226	methyltransferase
I6K35_RS02455	COG3716	PTS system mannose fructose sorbose family IID component
I6K35_RS02460	COG3715	PTS system
I6K35_RS02465	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS02465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K35_RS02470	COG1253	flavin adenine dinucleotide binding
I6K35_RS02475	COG2200	EAL domain
I6K35_RS02480	COG1760	l-serine dehydratase
I6K35_RS02500	COG0251	oxidation-reduction process
I6K35_RS02505	COG1199	ATP-dependent helicase activity
I6K35_RS02515	COG3065	identical protein binding
I6K35_RS02525	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K35_RS02535	COG2894	cell division
I6K35_RS02550	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K35_RS02560	COG3615	Tellurite resistance protein tehB
I6K35_RS02580	COG2719	SpoVR family
I6K35_RS02605	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K35_RS02615	COG4774	siderophore transport
I6K35_RS02625	COG2308	Evidence 4 Homologs of previously reported genes of
I6K35_RS02670	COG0583	DNA-binding transcription factor activity
I6K35_RS02675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K35_RS02690	COG1882	Formate acetyltransferase
I6K35_RS02725	COG0583	DNA-binding transcription factor activity
I6K35_RS02755	COG0583	DNA-binding transcription factor activity
I6K35_RS02770	COG3122	Protein conserved in bacteria
I6K35_RS02790	COG2885	chlorophyll binding
I6K35_RS02835	COG3039	Transposase
I6K35_RS02900	COG0012	GTP binding
I6K35_RS02920	COG0659	secondary active sulfate transmembrane transporter activity
I6K35_RS02950	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K35_RS02970	COG0387	Pfam Sodium calcium exchanger
I6K35_RS02975	COG4572	Cation transport regulator
I6K35_RS02980	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K35_RS02990	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K35_RS02995	COG3707	response regulator
I6K35_RS03000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K35_RS03010	COG1116	anion transmembrane transporter activity
I6K35_RS03015	COG2146	nitrite reductase [NAD(P)H] activity
I6K35_RS03015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K35_RS03020	COG0243	molybdopterin cofactor binding
I6K35_RS03025	COG4932	domain protein
I6K35_RS03030	COG2197	response regulator
I6K35_RS03035	COG3850	Histidine kinase
I6K35_RS03040	COG2223	nitrite transmembrane transporter activity
I6K35_RS03050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K35_RS03055	COG1140	nitrate reductase beta subunit
I6K35_RS03060	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K35_RS03065	COG2181	nitrate reductase activity
I6K35_RS03075	COG1522	sequence-specific DNA binding
I6K35_RS03110	COG0788	formyltetrahydrofolate deformylase activity
I6K35_RS03120	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K35_RS03125	COG0745	RESPONSE REGULATOR receiver
I6K35_RS03130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K35_RS03135	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K35_RS03145	COG1435	thymidine kinase activity
I6K35_RS03150	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS03150	COG1454	alcohol dehydrogenase
I6K35_RS03160	COG2095	MarC family integral membrane protein
I6K35_RS03165	COG4166	transmembrane transport
I6K35_RS03170	COG0601	transmembrane transport
I6K35_RS03175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K35_RS03180	COG0444	Belongs to the ABC transporter superfamily
I6K35_RS03190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K35_RS03210	COG2353	YceI-like domain
I6K35_RS03220	COG2350	Protein conserved in bacteria
I6K35_RS03230	COG3001	Fructosamine kinase
I6K35_RS03240	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K35_RS03245	COG3137	Salt-induced outer membrane protein
I6K35_RS03285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K35_RS03285	COG0072	phenylalanine-tRNA ligase activity
I6K35_RS03305	COG0583	DNA-binding transcription factor activity
I6K35_RS03325	COG0386	Belongs to the glutathione peroxidase family
I6K35_RS03335	COG0791	NLP P60 protein
I6K35_RS03345	COG4256	Hemin uptake protein
I6K35_RS03350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K35_RS03365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K35_RS03365	COG0574	Belongs to the PEP-utilizing enzyme family
I6K35_RS03375	COG0628	permease
I6K35_RS03380	COG0247	lactate metabolic process
I6K35_RS03380	COG0277	FAD linked oxidase domain protein
I6K35_RS03385	COG2050	protein possibly involved in aromatic compounds catabolism
I6K35_RS03390	COG2261	transglycosylase associated protein
I6K35_RS03415	COG1120	ATPase activity
I6K35_RS03420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS03430	COG0583	DNA-binding transcription factor activity
I6K35_RS03455	COG1304	FMN binding
I6K35_RS03460	COG1309	transcriptional regulator
I6K35_RS03480	COG0316	Belongs to the HesB IscA family
I6K35_RS03485	COG0719	Fe-S assembly protein
I6K35_RS03490	COG0396	ATPase activity
I6K35_RS03495	COG0719	Fe-S assembly protein
I6K35_RS03510	COG1376	ErfK ybiS ycfS ynhG family protein
I6K35_RS03540	COG1309	transcriptional regulator
I6K35_RS03545	COG1082	Xylose isomerase domain protein TIM barrel
I6K35_RS03545	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K35_RS03550	COG2271	Major facilitator Superfamily
I6K35_RS03555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K35_RS03565	COG1120	ATPase activity
I6K35_RS03570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS03575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K35_RS03580	COG1414	Transcriptional regulator
I6K35_RS03615	COG2814	Major facilitator Superfamily
I6K35_RS03635	COG0583	DNA-binding transcription factor activity
I6K35_RS03640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K35_RS03660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K35_RS03665	COG1116	anion transmembrane transporter activity
I6K35_RS03670	COG4774	siderophore transport
I6K35_RS03675	COG1120	ATPase activity
I6K35_RS03680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS03685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS03705	COG0765	amino acid transport
I6K35_RS03710	COG1126	abc transporter atp-binding protein
I6K35_RS03750	COG3383	formate dehydrogenase (NAD+) activity
I6K35_RS03755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K35_RS03765	COG1175	transmembrane transport
I6K35_RS03795	COG4133	protoheme IX ABC transporter activity
I6K35_RS03800	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K35_RS03805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K35_RS03820	COG1138	Cytochrome C-type biogenesis protein
I6K35_RS03825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K35_RS03830	COG3088	subunit of a heme lyase
I6K35_RS03830	COG4235	cytochrome complex assembly
I6K35_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS03880	COG2610	gluconate transmembrane transporter activity
I6K35_RS03885	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K35_RS03895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K35_RS03905	COG0583	DNA-binding transcription factor activity
I6K35_RS03925	COG0277	FAD linked oxidase domain protein
I6K35_RS03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K35_RS03955	COG0402	S-adenosylhomocysteine deaminase activity
I6K35_RS04010	COG4608	Belongs to the ABC transporter superfamily
I6K35_RS04015	COG0444	Belongs to the ABC transporter superfamily
I6K35_RS04040	COG0346	lactoylglutathione lyase activity
I6K35_RS04045	COG1349	DNA-binding transcription factor activity
I6K35_RS04080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K35_RS04135	COG0307	riboflavin synthase, alpha
I6K35_RS04140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K35_RS04145	COG2814	Major facilitator Superfamily
I6K35_RS04150	COG0583	DNA-binding transcription factor activity
I6K35_RS04165	COG2814	Major facilitator Superfamily
I6K35_RS04180	COG0791	NLP P60 protein
I6K35_RS04185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K35_RS04195	COG0346	lactoylglutathione lyase activity
I6K35_RS04200	COG1902	pentaerythritol trinitrate reductase activity
I6K35_RS04205	COG1309	transcriptional regulator
I6K35_RS04210	COG3313	Fe-S protein
I6K35_RS04215	COG4989	oxidoreductase activity
I6K35_RS04220	COG2032	superoxide dismutase activity
I6K35_RS04225	COG1289	transmembrane transporter activity
I6K35_RS04230	COG1566	PFAM secretion protein HlyD family protein
I6K35_RS04245	COG3706	GGDEF domain
I6K35_RS04260	COG3895	Periplasmic Protein
I6K35_RS04275	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K35_RS04280	COG0625	glutathione transferase activity
I6K35_RS04290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K35_RS04300	COG4659	FMN binding
I6K35_RS04335	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS04345	COG0673	inositol 2-dehydrogenase activity
I6K35_RS04375	COG3038	cytochrome b561
I6K35_RS04395	COG0583	DNA-binding transcription factor activity
I6K35_RS04400	COG3485	protocatechuate 3,4-dioxygenase
I6K35_RS04405	COG3485	protocatechuate 3,4-dioxygenase
I6K35_RS04410	COG5383	Protein conserved in bacteria
I6K35_RS04415	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K35_RS04430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K35_RS04435	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K35_RS04440	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K35_RS04445	COG0500	methyltransferase
I6K35_RS04460	COG2207	Transcriptional regulator
I6K35_RS04460	COG3708	Transcriptional regulator
I6K35_RS04465	COG3135	benzoate transporter
I6K35_RS04470	COG1396	sequence-specific DNA binding
I6K35_RS04480	COG0826	peptidase U32
I6K35_RS04500	COG1294	oxidase, subunit
I6K35_RS04505	COG1271	oxidase subunit
I6K35_RS04510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K35_RS04515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K35_RS04520	COG3842	ATPase activity
I6K35_RS04525	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K35_RS04530	COG1177	transmembrane transport
I6K35_RS04535	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS04570	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS04580	COG0747	negative chemotaxis
I6K35_RS04590	COG3238	Protein conserved in bacteria
I6K35_RS04595	COG1247	-acetyltransferase
I6K35_RS04605	COG2130	NADP-dependent
I6K35_RS04620	COG3691	Protein conserved in bacteria
I6K35_RS04625	COG1228	amidohydrolase
I6K35_RS04630	COG4772	TonB-dependent receptor
I6K35_RS04655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K35_RS04660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K35_RS04665	COG1473	amidohydrolase
I6K35_RS04670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K35_RS04675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS04685	COG0765	amino acid transport
I6K35_RS04690	COG1126	abc transporter atp-binding protein
I6K35_RS04700	COG0625	glutathione transferase activity
I6K35_RS04725	COG2211	Major facilitator Superfamily
I6K35_RS04740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K35_RS04745	COG3842	ATPase activity
I6K35_RS04750	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K35_RS04755	COG1178	ABC-type Fe3 transport system permease component
I6K35_RS04760	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K35_RS04765	COG2181	nitrate reductase activity
I6K35_RS04770	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K35_RS04775	COG1140	nitrate reductase beta subunit
I6K35_RS04780	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K35_RS04800	COG1414	Transcriptional regulator
I6K35_RS04805	COG4948	Mandelate Racemase Muconate Lactonizing
I6K35_RS04810	COG4829	muconolactone delta-isomerase
I6K35_RS04815	COG3485	protocatechuate 3,4-dioxygenase
I6K35_RS04825	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K35_RS04850	COG0437	4 iron, 4 sulfur cluster binding
I6K35_RS04855	COG2864	formate dehydrogenase
I6K35_RS04870	COG2326	polyphosphate kinase activity
I6K35_RS04880	COG2814	Major facilitator Superfamily
I6K35_RS04890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K35_RS04900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K35_RS04910	COG0747	negative chemotaxis
I6K35_RS04915	COG1064	alcohol dehydrogenase
I6K35_RS04930	COG0488	(ABC) transporter
I6K35_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS04975	COG3729	General stress protein
I6K35_RS04985	COG3685	Protein conserved in bacteria
I6K35_RS04995	COG0366	Alpha amylase catalytic
I6K35_RS05005	COG2323	membrane
I6K35_RS05015	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K35_RS05025	COG1764	response to oxidative stress
I6K35_RS05050	COG3781	membrane
I6K35_RS05055	COG0243	molybdopterin cofactor binding
I6K35_RS05060	COG0583	DNA-binding transcription factor activity
I6K35_RS05065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS05090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS05095	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K35_RS05100	COG2814	Major facilitator Superfamily
I6K35_RS05105	COG1285	pathogenesis
I6K35_RS05110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K35_RS05120	COG0583	DNA-binding transcription factor activity
I6K35_RS05140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K35_RS05140	COG0519	Catalyzes the synthesis of GMP from XMP
I6K35_RS05180	COG0596	Alpha beta hydrolase
I6K35_RS05190	COG2205	protein histidine kinase activity
I6K35_RS05205	COG0076	glutamate decarboxylase activity
I6K35_RS05210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K35_RS05215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K35_RS05220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K35_RS05225	COG1116	anion transmembrane transporter activity
I6K35_RS05230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K35_RS05245	COG0673	inositol 2-dehydrogenase activity
I6K35_RS05255	COG1609	Transcriptional regulator
I6K35_RS05260	COG3706	GGDEF domain
I6K35_RS05265	COG0402	S-adenosylhomocysteine deaminase activity
I6K35_RS05270	COG1953	Uracil, thiamine, allantoin
I6K35_RS05305	COG0596	Alpha beta hydrolase
I6K35_RS05315	COG2207	Transcriptional regulator
I6K35_RS05330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K35_RS05355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K35_RS05400	COG0765	amino acid transport
I6K35_RS05410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K35_RS05420	COG2070	2-Nitropropane dioxygenase
I6K35_RS05425	COG0583	DNA-binding transcription factor activity
I6K35_RS05435	COG1902	pentaerythritol trinitrate reductase activity
I6K35_RS05440	COG4529	Protein conserved in bacteria
I6K35_RS05445	COG0477	Major facilitator Superfamily
I6K35_RS05490	COG2223	nitrite transmembrane transporter activity
I6K35_RS05500	COG1609	Transcriptional regulator
I6K35_RS05505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS05515	COG3037	sugar-specific permease SgaT UlaA
I6K35_RS05520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K35_RS05530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K35_RS05550	COG0583	DNA-binding transcription factor activity
I6K35_RS05555	COG0583	DNA-binding transcription factor activity
I6K35_RS05560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K35_RS05570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K35_RS05585	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS05595	COG1609	Transcriptional regulator
I6K35_RS05625	COG1652	LysM domain
I6K35_RS05650	COG0456	acetyltransferase
I6K35_RS05650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K35_RS05660	COG0667	Aldo Keto reductase
I6K35_RS05665	COG0667	Aldo Keto reductase
I6K35_RS05670	COG3386	PFAM SMP-30 Gluconolaconase
I6K35_RS05675	COG0667	Aldo Keto reductase
I6K35_RS05700	COG2814	Major facilitator Superfamily
I6K35_RS05705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS05705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS05720	COG2819	hydrolase of the alpha beta superfamily
I6K35_RS05725	COG3300	MHYT domain
I6K35_RS05725	COG5001	Diguanylate cyclase
I6K35_RS05760	COG3188	usher protein
I6K35_RS05770	COG1649	PFAM Uncharacterised BCR, COG1649
I6K35_RS05775	COG3550	peptidyl-serine autophosphorylation
I6K35_RS05780	COG1396	sequence-specific DNA binding
I6K35_RS05785	COG2351	hydroxyisourate hydrolase activity
I6K35_RS05790	COG3195	allantoin biosynthetic process
I6K35_RS05790	COG3648	Uricase
I6K35_RS05795	COG2233	PERMEase
I6K35_RS05825	COG2207	Transcriptional regulator
I6K35_RS05840	COG4628	conserved protein (DUF2132)
I6K35_RS05860	COG2011	ABC-type metal ion transport system permease component
I6K35_RS05865	COG2070	2-Nitropropane dioxygenase
I6K35_RS05875	COG0477	Major facilitator Superfamily
I6K35_RS05945	COG2199	diguanylate cyclase activity
I6K35_RS05960	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS05965	COG0583	DNA-binding transcription factor activity
I6K35_RS05975	COG0039	L-malate dehydrogenase activity
I6K35_RS05980	COG1349	DNA-binding transcription factor activity
I6K35_RS05985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K35_RS05990	COG3395	kinase activity
I6K35_RS06000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K35_RS06005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K35_RS06010	COG2271	Major facilitator Superfamily
I6K35_RS06040	COG4977	sequence-specific DNA binding
I6K35_RS06050	COG0697	spore germination
I6K35_RS06055	COG2814	Major facilitator Superfamily
I6K35_RS06070	COG1129	ABC transporter
I6K35_RS06090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K35_RS06125	COG2223	nitrite transmembrane transporter activity
I6K35_RS06130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K35_RS06145	COG1349	DNA-binding transcription factor activity
I6K35_RS06150	COG2084	Dehydrogenase
I6K35_RS06155	COG3395	kinase activity
I6K35_RS06160	COG0235	Class ii aldolase
I6K35_RS06165	COG3622	Belongs to the hyi family
I6K35_RS06170	COG2610	gluconate transmembrane transporter activity
I6K35_RS06175	COG3708	Transcriptional regulator
I6K35_RS06175	COG2207	Transcriptional regulator
I6K35_RS06190	COG2200	EAL domain
I6K35_RS06195	COG1546	Belongs to the CinA family
I6K35_RS06200	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K35_RS06220	COG2197	response regulator
I6K35_RS06235	COG2135	peptidase activity
I6K35_RS06240	COG2207	Transcriptional regulator
I6K35_RS06250	COG0339	signal peptide processing
I6K35_RS06255	COG4221	oxidoreductase activity
I6K35_RS06260	COG1802	Transcriptional regulator
I6K35_RS06265	COG0589	response to stress
I6K35_RS06270	COG0246	Mannitol dehydrogenase
I6K35_RS06275	COG2271	Major facilitator Superfamily
I6K35_RS06290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K35_RS06305	COG0243	molybdopterin cofactor binding
I6K35_RS06310	COG0437	4 iron, 4 sulfur cluster binding
I6K35_RS06315	COG3302	dmso reductase anchor subunit
I6K35_RS06330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K35_RS06335	COG1940	carbohydrate kinase activity
I6K35_RS06340	COG0583	DNA-binding transcription factor activity
I6K35_RS06345	COG2814	Major facilitator Superfamily
I6K35_RS06350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K35_RS06360	COG3591	Belongs to the peptidase S1B family
I6K35_RS06380	COG0628	permease
I6K35_RS06410	COG0679	Auxin Efflux Carrier
I6K35_RS06420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K35_RS06445	COG3290	protein histidine kinase activity
I6K35_RS06450	COG4565	transcriptional regulatory protein
I6K35_RS06470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K35_RS06470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K35_RS06480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K35_RS06485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K35_RS06495	COG0183	Belongs to the thiolase family
I6K35_RS06500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K35_RS06510	COG1414	Transcriptional regulator
I6K35_RS06515	COG2840	Smr protein MutS2
I6K35_RS06520	COG0583	DNA-binding transcription factor activity
I6K35_RS06530	COG1473	amidohydrolase
I6K35_RS06535	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K35_RS06550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K35_RS06565	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K35_RS06570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K35_RS06585	COG0531	amino acid
I6K35_RS06595	COG3136	membrane protein required for alginate biosynthesis
I6K35_RS06600	COG0745	RESPONSE REGULATOR receiver
I6K35_RS06610	COG2205	protein histidine kinase activity
I6K35_RS06620	COG0114	fumarate hydratase activity
I6K35_RS06625	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K35_RS06625	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K35_RS06630	COG1482	cell wall glycoprotein biosynthetic process
I6K35_RS06635	COG5339	Protein conserved in bacteria
I6K35_RS06640	COG1609	Transcriptional regulator
I6K35_RS06645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K35_RS06645	COG1263	PTS System
I6K35_RS06650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K35_RS06675	COG2391	methyltransferase activity
I6K35_RS06680	COG0425	Belongs to the sulfur carrier protein TusA family
I6K35_RS06685	COG5562	phage envelope protein
I6K35_RS06690	COG0401	homolog of Blt101
I6K35_RS06695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K35_RS06700	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS06710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K35_RS06715	COG0477	Major facilitator Superfamily
I6K35_RS06720	COG1113	amino acid transport
I6K35_RS06725	COG2988	succinylglutamate desuccinylase activity
I6K35_RS06730	COG3724	N-succinylarginine dihydrolase activity
I6K35_RS06735	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS06740	COG3138	arginine N-succinyltransferase
I6K35_RS06745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K35_RS06755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K35_RS06760	COG0667	Aldo Keto reductase
I6K35_RS06765	COG0583	DNA-binding transcription factor activity
I6K35_RS06790	COG4122	O-methyltransferase activity
I6K35_RS06795	COG1643	Atp-dependent helicase
I6K35_RS06810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K35_RS06815	COG3327	negative regulation of DNA-templated transcription, initiation
I6K35_RS06820	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K35_RS06825	COG0183	Belongs to the thiolase family
I6K35_RS06830	COG2050	protein possibly involved in aromatic compounds catabolism
I6K35_RS06835	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K35_RS06840	COG1024	Enoyl-CoA hydratase
I6K35_RS06845	COG1024	Enoyl-CoA hydratase
I6K35_RS06850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K35_RS06855	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K35_RS06860	COG3396	Phenylacetate-CoA oxygenase
I6K35_RS06865	COG3460	Phenylacetate-CoA oxygenase
I6K35_RS06870	COG3396	Phenylacetate-CoA oxygenase
I6K35_RS06875	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS06875	COG2030	dehydratase
I6K35_RS06895	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS06900	COG2207	Transcriptional regulator
I6K35_RS06905	COG3784	Protein of unknown function (DUF1318)
I6K35_RS06915	COG2911	Protein conserved in bacteria
I6K35_RS06920	COG0586	Pfam SNARE associated Golgi protein
I6K35_RS06925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K35_RS06930	COG3187	Heat shock protein
I6K35_RS06935	COG3042	response to heat
I6K35_RS06940	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K35_RS06940	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K35_RS06940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K35_RS06940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K35_RS06945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K35_RS06955	COG0589	response to stress
I6K35_RS06965	COG0513	Belongs to the DEAD box helicase family
I6K35_RS06975	COG1349	DNA-binding transcription factor activity
I6K35_RS06980	COG0673	inositol 2-dehydrogenase activity
I6K35_RS06995	COG1113	amino acid transport
I6K35_RS07000	COG1522	sequence-specific DNA binding
I6K35_RS07010	COG1448	Aminotransferase
I6K35_RS07015	COG2011	ABC-type metal ion transport system permease component
I6K35_RS07025	COG1464	Belongs to the NlpA lipoprotein family
I6K35_RS07030	COG0436	Aminotransferase
I6K35_RS07035	COG0604	alcohol dehydrogenase
I6K35_RS07065	COG0583	DNA-binding transcription factor activity
I6K35_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS07090	COG1309	transcriptional regulator
I6K35_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS07200	COG2885	chlorophyll binding
I6K35_RS07225	COG0693	protein deglycase activity
I6K35_RS07230	COG1078	dGTPase activity
I6K35_RS07235	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS07240	COG0583	DNA-binding transcription factor activity
I6K35_RS07300	COG2205	protein histidine kinase activity
I6K35_RS07300	COG0784	Response regulator, receiver
I6K35_RS07300	COG5002	protein histidine kinase activity
I6K35_RS07305	COG3250	beta-galactosidase activity
I6K35_RS07310	COG0656	L-ascorbic acid biosynthetic process
I6K35_RS07340	COG4166	transmembrane transport
I6K35_RS07350	COG2866	Carboxypeptidase
I6K35_RS07355	COG4948	Mandelate Racemase Muconate Lactonizing
I6K35_RS07360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K35_RS07365	COG3180	Ammonia monooxygenase
I6K35_RS07375	COG1486	melibiose metabolic process
I6K35_RS07380	COG0583	DNA-binding transcription factor activity
I6K35_RS07390	COG3106	COG3106 Predicted ATPase
I6K35_RS07400	COG1983	PspC domain protein
I6K35_RS07410	COG1842	Phage shock protein A
I6K35_RS07415	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS07425	COG1473	amidohydrolase
I6K35_RS07440	COG0702	epimerase
I6K35_RS07455	COG2135	peptidase activity
I6K35_RS07465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K35_RS07470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K35_RS07475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K35_RS07525	COG1196	nuclear chromosome segregation
I6K35_RS07620	COG5484	DNA packaging
I6K35_RS07620	COG3728	DNA packaging
I6K35_RS07665	COG0484	heat shock protein binding
I6K35_RS07670	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K35_RS07730	COG1484	DNA-dependent DNA replication
I6K35_RS07790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K35_RS07810	COG4171	peptide transport system, permease
I6K35_RS07825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K35_RS07835	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K35_RS07840	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K35_RS07840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K35_RS07855	COG1349	DNA-binding transcription factor activity
I6K35_RS07865	COG0023	Translation Initiation Factor
I6K35_RS07875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K35_RS07880	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K35_RS07885	COG0671	phosphoesterase, PA-phosphatase related
I6K35_RS07895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K35_RS07920	COG0616	signal peptide processing
I6K35_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS07935	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K35_RS08050	COG0583	DNA-binding transcription factor activity
I6K35_RS08060	COG0009	L-threonylcarbamoyladenylate synthase
I6K35_RS08070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K35_RS08075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K35_RS08075	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K35_RS08080	COG0134	indole-3-glycerol-phosphate synthase activity
I6K35_RS08080	COG0135	phosphoribosylanthranilate isomerase activity
I6K35_RS08115	COG4774	siderophore transport
I6K35_RS08125	COG3047	cAMP biosynthetic process
I6K35_RS08130	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K35_RS08160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K35_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS08170	COG1988	membrane-bound metal-dependent
I6K35_RS08175	COG1823	symporter activity
I6K35_RS08185	COG0753	catalase activity
I6K35_RS08195	COG1486	melibiose metabolic process
I6K35_RS08200	COG1917	Cupin 2, conserved barrel domain protein
I6K35_RS08200	COG2169	Transcriptional regulator
I6K35_RS08205	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K35_RS08210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS08220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS08225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K35_RS08235	COG0322	excinuclease ABC activity
I6K35_RS08240	COG3678	ATP-independent chaperone mediated protein folding
I6K35_RS08250	COG3724	N-succinylarginine dihydrolase activity
I6K35_RS08260	COG3138	arginine N-succinyltransferase
I6K35_RS08270	COG0708	Exodeoxyribonuclease III
I6K35_RS08275	COG0398	Pfam SNARE associated Golgi protein
I6K35_RS08280	COG0398	Pfam SNARE associated Golgi protein
I6K35_RS08285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K35_RS08290	COG4134	Bacterial extracellular solute-binding protein
I6K35_RS08295	COG4135	transport system, permease component
I6K35_RS08300	COG4136	ATPase activity
I6K35_RS08305	COG2897	thiosulfate sulfurtransferase activity
I6K35_RS08310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K35_RS08315	COG0494	nUDIX hydrolase
I6K35_RS08320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K35_RS08325	COG0604	alcohol dehydrogenase
I6K35_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS08325	COG3321	synthase
I6K35_RS08330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K35_RS08335	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K35_RS08345	COG0778	Nitroreductase
I6K35_RS08350	COG0616	signal peptide processing
I6K35_RS08355	COG0252	asparaginase activity
I6K35_RS08360	COG1335	isochorismatase
I6K35_RS08375	COG3139	Protein of unknown function (DUF1315)
I6K35_RS08395	COG0656	L-ascorbic acid biosynthetic process
I6K35_RS08400	COG3713	MltA-interacting MipA family protein
I6K35_RS08550	COG2200	EAL domain
I6K35_RS08550	COG2199	diguanylate cyclase activity
I6K35_RS08600	COG2766	serine protein kinase
I6K35_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS08645	COG0583	DNA-binding transcription factor activity
I6K35_RS08650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K35_RS08655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K35_RS08665	COG0859	PFAM glycosyl transferase family 9
I6K35_RS08670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K35_RS08680	COG2207	Transcriptional regulator
I6K35_RS08685	COG2807	transmembrane transport
I6K35_RS08690	COG0504	CTP synthase activity
I6K35_RS08695	COG1683	Conserved Protein
I6K35_RS08700	COG3189	MarR family transcriptional regulator
I6K35_RS08705	COG3042	response to heat
I6K35_RS08710	COG2199	diguanylate cyclase activity
I6K35_RS08710	COG2203	Gaf domain
I6K35_RS08730	COG3182	Iron-regulated membrane protein
I6K35_RS08740	COG1560	Kdo2-lipid A biosynthetic process
I6K35_RS08750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K35_RS08755	COG3706	GGDEF domain
I6K35_RS08760	COG0583	DNA-binding transcription factor activity
I6K35_RS08765	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K35_RS08795	COG1294	oxidase, subunit
I6K35_RS08800	COG1271	oxidase subunit
I6K35_RS08805	COG3546	catalase activity
I6K35_RS08810	COG3685	Protein conserved in bacteria
I6K35_RS08815	COG3685	Protein conserved in bacteria
I6K35_RS08820	COG3729	General stress protein
I6K35_RS08825	COG1063	alcohol dehydrogenase
I6K35_RS08830	COG3813	Protein conserved in bacteria
I6K35_RS08850	COG0640	Transcriptional regulator
I6K35_RS08855	COG0538	isocitrate dehydrogenase activity
I6K35_RS08860	COG1187	pseudouridine synthase activity
I6K35_RS08880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K35_RS08900	COG2205	protein histidine kinase activity
I6K35_RS08905	COG2850	peptidyl-arginine hydroxylation
I6K35_RS08925	COG1177	transmembrane transport
I6K35_RS08940	COG0318	PFAM AMP-dependent synthetase and ligase
I6K35_RS08945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K35_RS08950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K35_RS08955	COG0698	ribose 5-phosphate isomerase
I6K35_RS08970	COG3395	kinase activity
I6K35_RS08985	COG2390	Transcriptional regulator
I6K35_RS08995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K35_RS09005	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K35_RS09015	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K35_RS09025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K35_RS09030	COG1376	ErfK ybiS ycfS ynhG family protein
I6K35_RS09030	COG1388	LysM domain
I6K35_RS09045	COG1309	transcriptional regulator
I6K35_RS09060	COG3134	Outer membrane lipoprotein
I6K35_RS09065	COG1252	NADH dehydrogenase
I6K35_RS09090	COG5633	Lipoprotein
I6K35_RS09095	COG0537	adenosine 5'-monophosphoramidase activity
I6K35_RS09105	COG0084	hydrolase, TatD family'
I6K35_RS09110	COG0470	DNA polymerase III
I6K35_RS09120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K35_RS09125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K35_RS09130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K35_RS09145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K35_RS09165	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K35_RS09185	COG1530	ribonuclease E activity
I6K35_RS09190	COG0583	DNA-binding transcription factor activity
I6K35_RS09195	COG2814	Major facilitator Superfamily
I6K35_RS09215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K35_RS09260	COG1560	Kdo2-lipid A biosynthetic process
I6K35_RS09275	COG5645	(Lipo)protein
I6K35_RS09310	COG3381	protein complex oligomerization
I6K35_RS09330	COG0583	DNA-binding transcription factor activity
I6K35_RS09340	COG1335	isochorismatase
I6K35_RS09350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K35_RS09355	COG1702	phosphate starvation-inducible protein PhoH
I6K35_RS09375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K35_RS09385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K35_RS09400	COG1309	transcriptional regulator
I6K35_RS09435	COG2233	PERMEase
I6K35_RS09445	COG3729	General stress protein
I6K35_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS09490	COG0531	amino acid
I6K35_RS09495	COG0174	glutamine synthetase
I6K35_RS09500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K35_RS09505	COG1396	sequence-specific DNA binding
I6K35_RS09505	COG1917	Cupin 2, conserved barrel domain protein
I6K35_RS09510	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS09515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K35_RS09520	COG0583	DNA-binding transcription factor activity
I6K35_RS09525	COG0473	3-isopropylmalate dehydrogenase activity
I6K35_RS09530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K35_RS09535	COG4638	Rieske (2fe-2S)
I6K35_RS09540	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS09545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K35_RS09570	COG0670	Belongs to the BI1 family
I6K35_RS09585	COG2207	Transcriptional regulator
I6K35_RS09590	COG1881	PFAM PEBP family protein
I6K35_RS09615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS09620	COG2274	protein secretion by the type I secretion system
I6K35_RS09635	COG1832	CoA-binding protein
I6K35_RS09645	COG0210	DNA helicase
I6K35_RS09650	COG3304	Inner membrane component domain
I6K35_RS09655	COG1289	transmembrane transporter activity
I6K35_RS09660	COG3070	regulator of competence-specific genes
I6K35_RS09680	COG1067	ATP-dependent peptidase activity
I6K35_RS09690	COG3130	regulation of translation
I6K35_RS09695	COG3009	Protein conserved in bacteria
I6K35_RS09700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K35_RS09700	COG3008	intermembrane lipid transfer
I6K35_RS09705	COG2995	paraquat-inducible protein a
I6K35_RS09710	COG0488	(ABC) transporter
I6K35_RS09720	COG0633	Ferredoxin
I6K35_RS09720	COG3217	Mosc domain protein beta barrel domain protein
I6K35_RS09735	COG0431	NADPH-dependent FMN reductase
I6K35_RS09740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K35_RS09745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K35_RS09750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K35_RS09760	COG0308	aminopeptidase N
I6K35_RS09770	COG1473	amidohydrolase
I6K35_RS09780	COG0814	amino acid
I6K35_RS09800	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K35_RS09805	COG1448	Aminotransferase
I6K35_RS09810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K35_RS09815	COG3108	Peptidase M15
I6K35_RS09820	COG2989	Protein conserved in bacteria
I6K35_RS09830	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K35_RS09840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K35_RS09845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K35_RS09850	COG3173	Aminoglycoside phosphotransferase
I6K35_RS09865	COG3214	Protein conserved in bacteria
I6K35_RS09880	COG0658	competence protein
I6K35_RS09880	COG2333	competence protein COMEC
I6K35_RS09890	COG0539	negative regulation of cytoplasmic translation
I6K35_RS09910	COG2323	membrane
I6K35_RS09915	COG1944	ATP diphosphatase activity
I6K35_RS09920	COG2116	formate transmembrane transporter activity
I6K35_RS09925	COG1882	Formate acetyltransferase
I6K35_RS09930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K35_RS09935	COG0477	Major facilitator Superfamily
I6K35_RS09940	COG3302	dmso reductase anchor subunit
I6K35_RS09945	COG0437	4 iron, 4 sulfur cluster binding
I6K35_RS09950	COG0243	molybdopterin cofactor binding
I6K35_RS09960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K35_RS09970	COG1674	ftsk spoiiie
I6K35_RS09970	COG1178	ABC-type Fe3 transport system permease component
I6K35_RS09980	COG0492	ferredoxin-NADP+ reductase activity
I6K35_RS09985	COG4988	ABC transporter
I6K35_RS09990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K35_RS10005	COG0542	response to heat
I6K35_RS10015	COG1278	Cold shock
I6K35_RS10025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS10030	COG3593	DNA synthesis involved in DNA repair
I6K35_RS10040	COG2431	L-lysine efflux transmembrane transporter activity
I6K35_RS10050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K35_RS10060	COG0028	Belongs to the TPP enzyme family
I6K35_RS10065	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K35_RS10070	COG0702	epimerase
I6K35_RS10075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K35_RS10080	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K35_RS10085	COG3706	GGDEF domain
I6K35_RS10085	COG2203	Gaf domain
I6K35_RS10085	COG4251	negative regulation of phosphorylation
I6K35_RS10085	COG5001	Diguanylate cyclase
I6K35_RS10100	COG1126	abc transporter atp-binding protein
I6K35_RS10105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS10110	COG4215	(ABC) transporter
I6K35_RS10115	COG4160	amino acid transport
I6K35_RS10120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS10125	COG5002	protein histidine kinase activity
I6K35_RS10130	COG0745	RESPONSE REGULATOR receiver
I6K35_RS10145	COG1177	transmembrane transport
I6K35_RS10150	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K35_RS10155	COG3842	ATPase activity
I6K35_RS10160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K35_RS10175	COG0778	Nitroreductase
I6K35_RS10200	COG3226	Transcriptional regulator
I6K35_RS10205	COG0738	Major facilitator superfamily
I6K35_RS10210	COG0561	phosphatase activity
I6K35_RS10215	COG2814	Major facilitator Superfamily
I6K35_RS10220	COG0671	phosphoesterase, PA-phosphatase related
I6K35_RS10225	COG1349	DNA-binding transcription factor activity
I6K35_RS10230	COG1686	Belongs to the peptidase S11 family
I6K35_RS10240	COG0625	glutathione transferase activity
I6K35_RS10245	COG2133	pyrroloquinoline quinone binding
I6K35_RS10255	COG2223	nitrite transmembrane transporter activity
I6K35_RS10275	COG0747	negative chemotaxis
I6K35_RS10285	COG1446	asparaginase
I6K35_RS10290	COG0303	'Molybdopterin
I6K35_RS10295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K35_RS10300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K35_RS10305	COG1882	Formate acetyltransferase
I6K35_RS10310	COG0561	phosphatase activity
I6K35_RS10320	COG1609	Transcriptional regulator
I6K35_RS10325	COG2271	Major facilitator Superfamily
I6K35_RS10335	COG0488	(ABC) transporter
I6K35_RS10340	COG2365	Tyrosine phosphatase family
I6K35_RS10345	COG1376	ErfK ybiS ycfS ynhG family protein
I6K35_RS10350	COG2188	Transcriptional regulator
I6K35_RS10355	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS10360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K35_RS10375	COG2194	sulfuric ester hydrolase activity
I6K35_RS10380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K35_RS10395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS10400	COG0765	amino acid transport
I6K35_RS10405	COG1126	abc transporter atp-binding protein
I6K35_RS10410	COG0668	transmembrane transport
I6K35_RS10420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K35_RS10430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K35_RS10440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K35_RS10445	COG1199	ATP-dependent helicase activity
I6K35_RS10450	COG0513	Belongs to the DEAD box helicase family
I6K35_RS10455	COG3958	Transketolase
I6K35_RS10460	COG3959	Transketolase, thiamine diphosphate binding domain
I6K35_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS10470	COG2271	Major facilitator Superfamily
I6K35_RS10480	COG0583	DNA-binding transcription factor activity
I6K35_RS10485	COG1309	transcriptional regulator
I6K35_RS10490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS10495	COG1131	(ABC) transporter
I6K35_RS10500	COG0842	Transport permease protein
I6K35_RS10505	COG0842	Transport permease protein
I6K35_RS10515	COG3568	Endonuclease Exonuclease Phosphatase
I6K35_RS10520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K35_RS10525	COG0392	lysyltransferase activity
I6K35_RS10530	COG0670	Belongs to the BI1 family
I6K35_RS10535	COG0314	molybdopterin synthase activity
I6K35_RS10540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K35_RS10550	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K35_RS10570	COG0745	RESPONSE REGULATOR receiver
I6K35_RS10575	COG0642	Histidine kinase
I6K35_RS10600	COG2226	methyltransferase
I6K35_RS10615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K35_RS10620	COG1881	PFAM PEBP family protein
I6K35_RS10660	COG4677	pectinesterase activity
I6K35_RS10670	COG0589	response to stress
I6K35_RS10675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS10710	COG0789	Transcriptional regulator
I6K35_RS10715	COG2200	EAL domain
I6K35_RS10740	COG0561	phosphatase activity
I6K35_RS10750	COG4149	molybdate abc transporter
I6K35_RS10755	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K35_RS10765	COG2005	Transcriptional regulator
I6K35_RS10765	COG3585	molybdate ion transport
I6K35_RS10770	COG1119	ATPase activity
I6K35_RS10780	COG1085	galactose-1-phosphate uridylyltransferase
I6K35_RS10790	COG2017	converts alpha-aldose to the beta-anomer
I6K35_RS10800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K35_RS10815	COG3201	nicotinamide mononucleotide transporter
I6K35_RS10820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K35_RS10865	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K35_RS10870	COG2885	chlorophyll binding
I6K35_RS10880	COG3064	Membrane
I6K35_RS10885	COG0848	biopolymer transport protein
I6K35_RS10890	COG0811	peptide transport
I6K35_RS10895	COG0824	Thioesterase
I6K35_RS10900	COG3790	cyd operon protein YbgE
I6K35_RS10905	COG4890	Cyd operon protein YbgT
I6K35_RS10910	COG1294	oxidase, subunit
I6K35_RS10915	COG1271	oxidase subunit
I6K35_RS10920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K35_RS10930	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K35_RS10935	COG0567	Dehydrogenase, E1 component
I6K35_RS10940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K35_RS10945	COG1053	succinate dehydrogenase
I6K35_RS10950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K35_RS10955	COG2009	succinate dehydrogenase
I6K35_RS10990	COG1984	allophanate hydrolase subunit 2
I6K35_RS10995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K35_RS11010	COG0415	Belongs to the DNA photolyase family
I6K35_RS11040	COG2205	protein histidine kinase activity
I6K35_RS11045	COG0745	RESPONSE REGULATOR receiver
I6K35_RS11055	COG0033	Phosphoglucomutase
I6K35_RS11065	COG0596	Alpha beta hydrolase
I6K35_RS11080	COG0735	belongs to the Fur family
I6K35_RS11120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K35_RS11125	COG1846	Transcriptional regulator
I6K35_RS11125	COG1940	carbohydrate kinase activity
I6K35_RS11130	COG0647	UMP catabolic process
I6K35_RS11135	COG0367	asparagine synthase
I6K35_RS11175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K35_RS11185	COG1702	phosphate starvation-inducible protein PhoH
I6K35_RS11210	COG0765	amino acid transport
I6K35_RS11215	COG0765	amino acid transport
I6K35_RS11220	COG1126	abc transporter atp-binding protein
I6K35_RS11235	COG2888	peptidyl-tyrosine sulfation
I6K35_RS11250	COG1466	dna polymerase III delta subunit
I6K35_RS11265	COG0799	negative regulation of ribosome biogenesis
I6K35_RS11275	COG0768	penicillin binding
I6K35_RS11280	COG0772	Belongs to the SEDS family
I6K35_RS11285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K35_RS11290	COG1686	Belongs to the peptidase S11 family
I6K35_RS11305	COG0583	DNA-binding transcription factor activity
I6K35_RS11320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K35_RS11340	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K35_RS11345	COG3719	Belongs to the RNase T2 family
I6K35_RS11350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K35_RS11370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K35_RS11375	COG0583	DNA-binding transcription factor activity
I6K35_RS11380	COG3969	phosphoadenosine phosphosulfate
I6K35_RS11385	COG1475	DNA binding
I6K35_RS11390	COG0436	Aminotransferase
I6K35_RS11415	COG1129	ABC transporter
I6K35_RS11420	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS11425	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS11435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K35_RS11450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K35_RS11460	COG0402	S-adenosylhomocysteine deaminase activity
I6K35_RS11470	COG0483	inositol monophosphate 1-phosphatase activity
I6K35_RS11475	COG2271	Major facilitator Superfamily
I6K35_RS11505	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS11510	COG1129	ABC transporter
I6K35_RS11515	COG0371	Dehydrogenase
I6K35_RS11520	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS11535	COG2879	small protein
I6K35_RS11540	COG1966	Carbon starvation protein
I6K35_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS11555	COG1535	isochorismatase
I6K35_RS11555	COG3433	isochorismatase activity
I6K35_RS11560	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K35_RS11565	COG1169	isochorismate synthase
I6K35_RS11570	COG4592	Periplasmic binding protein
I6K35_RS11580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS11585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS11590	COG1120	ATPase activity
I6K35_RS11595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K35_RS11595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K35_RS11600	COG3251	PFAM MbtH domain protein
I6K35_RS11605	COG2382	esterase
I6K35_RS11610	COG4771	TonB-dependent receptor
I6K35_RS11615	COG2977	Belongs to the P-Pant transferase superfamily
I6K35_RS11620	COG3958	Transketolase
I6K35_RS11625	COG3959	Transketolase, thiamine diphosphate binding domain
I6K35_RS11630	COG2390	Transcriptional regulator
I6K35_RS11635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K35_RS11640	COG1879	ABC-type sugar transport system periplasmic component
I6K35_RS11650	COG1129	ABC transporter
I6K35_RS11655	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS11665	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS11675	COG0583	DNA-binding transcription factor activity
I6K35_RS11680	COG0668	transmembrane transport
I6K35_RS11690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K35_RS11715	COG0747	negative chemotaxis
I6K35_RS11720	COG0601	transmembrane transport
I6K35_RS11725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K35_RS11730	COG0444	Belongs to the ABC transporter superfamily
I6K35_RS11735	COG4608	Belongs to the ABC transporter superfamily
I6K35_RS11740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K35_RS11745	COG4221	oxidoreductase activity
I6K35_RS11755	COG4215	(ABC) transporter
I6K35_RS11760	COG0765	amino acid transport
I6K35_RS11765	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K35_RS11780	COG0697	spore germination
I6K35_RS11795	COG4608	Belongs to the ABC transporter superfamily
I6K35_RS11800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K35_RS11810	COG4166	transmembrane transport
I6K35_RS11820	COG3698	Phosphodiester glycosidase
I6K35_RS11860	COG2315	Protein conserved in bacteria
I6K35_RS11865	COG0778	Nitroreductase
I6K35_RS11890	COG0477	Major facilitator Superfamily
I6K35_RS11895	COG0668	transmembrane transport
I6K35_RS11900	COG1609	Transcriptional regulator
I6K35_RS11910	COG0673	inositol 2-dehydrogenase activity
I6K35_RS11920	COG2211	Major facilitator Superfamily
I6K35_RS11925	COG1113	amino acid transport
I6K35_RS11940	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS11945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K35_RS11955	COG0531	amino acid
I6K35_RS11970	COG4680	protein conserved in bacteria
I6K35_RS12010	COG0667	Aldo Keto reductase
I6K35_RS12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS12020	COG1473	amidohydrolase
I6K35_RS12050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS12055	COG1120	ATPase activity
I6K35_RS12060	COG1566	PFAM secretion protein HlyD family protein
I6K35_RS12105	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS12110	COG1129	ABC transporter
I6K35_RS12125	COG0673	inositol 2-dehydrogenase activity
I6K35_RS12155	COG3104	oligopeptide transport
I6K35_RS12160	COG1982	Orn Lys Arg decarboxylase major
I6K35_RS12165	COG0531	amino acid
I6K35_RS12170	COG3710	Transcriptional regulator
I6K35_RS12180	COG1560	Kdo2-lipid A biosynthetic process
I6K35_RS12225	COG2501	S4 domain
I6K35_RS12235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K35_RS12250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K35_RS12255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K35_RS12275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K35_RS12280	COG4181	ATPase activity
I6K35_RS12285	COG2755	lipolytic protein G-D-S-L family
I6K35_RS12290	COG0300	oxidoreductase activity
I6K35_RS12295	COG3118	belongs to the thioredoxin family
I6K35_RS12300	COG0390	transport system, permease component
I6K35_RS12305	COG4619	ABC transporter
I6K35_RS12310	COG0330	HflC and HflK could
I6K35_RS12315	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K35_RS12330	COG3735	TraB family
I6K35_RS12335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K35_RS12345	COG2223	nitrite transmembrane transporter activity
I6K35_RS12350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K35_RS12350	COG4651	solute:proton antiporter activity
I6K35_RS12355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K35_RS12395	COG2832	Protein of unknown function (DUF454)
I6K35_RS12400	COG3923	Primosomal replication protein n
I6K35_RS12410	COG5464	transposase or invertase
I6K35_RS12415	COG3264	Mechanosensitive ion channel
I6K35_RS12415	COG1196	nuclear chromosome segregation
I6K35_RS12420	COG1309	transcriptional regulator
I6K35_RS12425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS12430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K35_RS12445	COG0110	maltose O-acetyltransferase activity
I6K35_RS12495	COG1874	Beta-galactosidase
I6K35_RS12500	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K35_RS12505	COG3833	ABC-type maltose transport systems, permease component
I6K35_RS12510	COG1175	transmembrane transport
I6K35_RS12515	COG2182	Extracellular solute-binding protein
I6K35_RS12525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K35_RS12540	COG2364	Membrane
I6K35_RS12570	COG3695	enzyme binding
I6K35_RS12575	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K35_RS12580	COG1946	Acyl-CoA thioesterase
I6K35_RS12585	COG0004	ammonium transporteR
I6K35_RS12590	COG0347	Belongs to the P(II) protein family
I6K35_RS12595	COG1132	(ABC) transporter
I6K35_RS12600	COG1132	(ABC) transporter
I6K35_RS12605	COG1522	sequence-specific DNA binding
I6K35_RS12620	COG4533	DNA binding
I6K35_RS12630	COG0824	Thioesterase
I6K35_RS12635	COG1555	photosystem II stabilization
I6K35_RS12640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K35_RS12645	COG0776	regulation of translation
I6K35_RS12650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K35_RS12670	COG0271	Belongs to the BolA IbaG family
I6K35_RS12675	COG3056	Lipoprotein
I6K35_RS12680	COG2223	nitrite transmembrane transporter activity
I6K35_RS12685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K35_RS12690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K35_RS12695	COG1845	cytochrome c oxidase, subunit III
I6K35_RS12700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K35_RS12715	COG1414	Transcriptional regulator
I6K35_RS12720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K35_RS12725	COG1053	succinate dehydrogenase
I6K35_RS12735	COG1053	succinate dehydrogenase
I6K35_RS12750	COG0673	inositol 2-dehydrogenase activity
I6K35_RS12755	COG2814	Major facilitator Superfamily
I6K35_RS12765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K35_RS12770	COG0693	protein deglycase activity
I6K35_RS12790	COG0142	geranyltranstransferase activity
I6K35_RS12800	COG0667	Aldo Keto reductase
I6K35_RS12805	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K35_RS12810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K35_RS12825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K35_RS12825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K35_RS12835	COG4238	major outer membrane lipoprotein
I6K35_RS12855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K35_RS12860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K35_RS12865	COG1862	Preprotein translocase
I6K35_RS12890	COG0450	alkyl hydroperoxide reductase
I6K35_RS12895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS12910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K35_RS12920	COG1228	amidohydrolase
I6K35_RS12930	COG1335	isochorismatase
I6K35_RS12935	COG0583	DNA-binding transcription factor activity
I6K35_RS12940	COG0366	Alpha amylase catalytic
I6K35_RS12965	COG0420	3'-5' exonuclease activity
I6K35_RS12970	COG0419	ATPase involved in DNA repair
I6K35_RS12975	COG1940	carbohydrate kinase activity
I6K35_RS12990	COG4126	flavin adenine dinucleotide binding
I6K35_RS13000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K35_RS13005	COG3416	Protein conserved in bacteria
I6K35_RS13015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K35_RS13025	COG1785	Belongs to the alkaline phosphatase family
I6K35_RS13065	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K35_RS13070	COG1335	isochorismatase
I6K35_RS13075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K35_RS13080	COG0113	porphobilinogen synthase activity
I6K35_RS13085	COG1943	Transposase
I6K35_RS13095	COG2175	clavaminate synthase activity
I6K35_RS13100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K35_RS13105	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K35_RS13110	COG4521	taurine ABC transporter
I6K35_RS13115	COG2040	homocysteine
I6K35_RS13120	COG0833	amino acid
I6K35_RS13135	COG4303	Ethanolamine ammonia lyase large subunit
I6K35_RS13140	COG4302	ethanolamine ammonia-lyase activity
I6K35_RS13180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS13185	COG1126	abc transporter atp-binding protein
I6K35_RS13190	COG4597	amino acid ABC transporter
I6K35_RS13195	COG0765	amino acid transport
I6K35_RS13210	COG3188	usher protein
I6K35_RS13235	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K35_RS13245	COG3639	organic phosphonate transmembrane transporter activity
I6K35_RS13265	COG0791	NLP P60 protein
I6K35_RS13290	COG0582	viral genome integration into host DNA
I6K35_RS13390	COG1403	HNH endonuclease
I6K35_RS13400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K35_RS13405	COG0022	dehydrogenase e1 component
I6K35_RS13410	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K35_RS13415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K35_RS13435	COG1070	Carbohydrate kinase
I6K35_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS13445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K35_RS13450	COG3775	system Galactitol-specific IIC component
I6K35_RS13455	COG0625	glutathione transferase activity
I6K35_RS13460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K35_RS13475	COG0579	oxidoreductase
I6K35_RS13480	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS13485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K35_RS13490	COG1113	amino acid transport
I6K35_RS13495	COG1802	Transcriptional regulator
I6K35_RS13505	COG0583	DNA-binding transcription factor activity
I6K35_RS13515	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS13545	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K35_RS13550	COG0454	-acetyltransferase
I6K35_RS13565	COG2991	Protein conserved in bacteria
I6K35_RS13580	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K35_RS13585	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K35_RS13600	COG3034	peptidoglycan biosynthetic process
I6K35_RS13605	COG0121	glutamine amidotransferase
I6K35_RS13615	COG1960	acyl-CoA dehydrogenase activity
I6K35_RS13620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K35_RS13630	COG0583	DNA-binding transcription factor activity
I6K35_RS13640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K35_RS13650	COG2226	methyltransferase
I6K35_RS13660	COG1388	LysM domain
I6K35_RS13660	COG0741	lytic transglycosylase activity
I6K35_RS13665	COG2226	methyltransferase
I6K35_RS13675	COG2814	Major facilitator Superfamily
I6K35_RS13680	COG0583	DNA-binding transcription factor activity
I6K35_RS13685	COG0656	L-ascorbic acid biosynthetic process
I6K35_RS13720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K35_RS13730	COG2011	ABC-type metal ion transport system permease component
I6K35_RS13735	COG1464	Belongs to the NlpA lipoprotein family
I6K35_RS13745	COG1720	tRNA m6t6A37 methyltransferase activity
I6K35_RS13755	COG0791	NLP P60 protein
I6K35_RS13760	COG3015	lipoprotein NlpE involved in copper resistance
I6K35_RS13765	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K35_RS13780	COG4568	rho-dependent transcription termination
I6K35_RS13790	COG0346	lactoylglutathione lyase activity
I6K35_RS13795	COG1982	Orn Lys Arg decarboxylase major
I6K35_RS13805	COG0587	DNA-directed DNA polymerase activity
I6K35_RS13835	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K35_RS13845	COG0750	zinc metalloprotease
I6K35_RS13850	COG0575	Belongs to the CDS family
I6K35_RS13860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K35_RS13885	COG0024	Methionine aminopeptidase
I6K35_RS13890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K35_RS13905	COG3835	regulator
I6K35_RS13910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K35_RS13930	COG2860	membrane
I6K35_RS13950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS13955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K35_RS13960	COG1120	ATPase activity
I6K35_RS13965	COG4774	siderophore transport
I6K35_RS13970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K35_RS14065	COG1643	Atp-dependent helicase
I6K35_RS14070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K35_RS14090	COG0617	tRNA 3'-terminal CCA addition
I6K35_RS14095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K35_RS14115	COG0726	polysaccharide deacetylase
I6K35_RS14120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS14125	COG0842	Transport permease protein
I6K35_RS14130	COG1131	(ABC) transporter
I6K35_RS14135	COG0288	reversible hydration of carbon dioxide
I6K35_RS14150	COG4993	Dehydrogenase
I6K35_RS14155	COG2132	Multicopper oxidase
I6K35_RS14200	COG3064	Membrane
I6K35_RS14215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K35_RS14220	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K35_RS14225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K35_RS14230	COG2186	Transcriptional regulator
I6K35_RS14235	COG1113	amino acid transport
I6K35_RS14240	COG2211	Major facilitator Superfamily
I6K35_RS14245	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K35_RS14250	COG3725	Membrane protein required for beta-lactamase induction
I6K35_RS14265	COG4969	Belongs to the N-Me-Phe pilin family
I6K35_RS14270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K35_RS14275	COG1459	type II secretion system
I6K35_RS14300	COG0494	nUDIX hydrolase
I6K35_RS14320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K35_RS14325	COG0849	cell division
I6K35_RS14350	COG0772	Belongs to the SEDS family
I6K35_RS14365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K35_RS14370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K35_RS14375	COG0768	penicillin binding
I6K35_RS14395	COG1609	Transcriptional regulator
I6K35_RS14405	COG0028	Belongs to the TPP enzyme family
I6K35_RS14460	COG0583	DNA-binding transcription factor activity
I6K35_RS14465	COG2271	Major facilitator Superfamily
I6K35_RS14470	COG2814	Major facilitator Superfamily
I6K35_RS14490	COG1178	ABC-type Fe3 transport system permease component
I6K35_RS14500	COG0586	Pfam SNARE associated Golgi protein
I6K35_RS14520	COG0235	Class ii aldolase
I6K35_RS14525	COG0417	DNA replication proofreading
I6K35_RS14535	COG0564	pseudouridine synthase activity
I6K35_RS14545	COG3493	citrate carrier protein
I6K35_RS14560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K35_RS14565	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K35_RS14575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K35_RS14620	COG0505	Belongs to the CarA family
I6K35_RS14685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K35_RS14710	COG1047	Peptidyl-prolyl cis-trans
I6K35_RS14725	COG0196	riboflavin kinase activity
I6K35_RS14735	COG0583	DNA-binding transcription factor activity
I6K35_RS14760	COG4735	regulation of single-species biofilm formation
I6K35_RS14765	COG1584	GPR1 FUN34 yaaH family protein
I6K35_RS14770	COG0477	Major facilitator Superfamily
I6K35_RS14775	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K35_RS14780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K35_RS14785	COG1115	amino acid carrier protein
I6K35_RS14800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K35_RS14810	COG0460	homoserine dehydrogenase
I6K35_RS14810	COG0527	aspartate kinase activity
I6K35_RS14820	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K35_RS14830	COG0745	RESPONSE REGULATOR receiver
I6K35_RS14835	COG4452	Inner membrane protein CreD
I6K35_RS14840	COG2205	protein histidine kinase activity
I6K35_RS14845	COG0745	RESPONSE REGULATOR receiver
I6K35_RS14850	COG3045	CreA protein
I6K35_RS14855	COG3708	Transcriptional regulator
I6K35_RS14855	COG2207	Transcriptional regulator
I6K35_RS14875	COG0741	lytic transglycosylase activity
I6K35_RS14880	COG0488	(ABC) transporter
I6K35_RS14890	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K35_RS14895	COG0560	Phosphoserine phosphatase
I6K35_RS14900	COG3726	membrane protein affecting hemolysin expression
I6K35_RS14930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K35_RS14935	COG0084	hydrolase, TatD family'
I6K35_RS14940	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K35_RS14950	COG2823	Periplasmic or secreted lipoprotein
I6K35_RS14960	COG1011	Hydrolase
I6K35_RS14965	COG0456	acetyltransferase
I6K35_RS14970	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K35_RS15005	COG3706	GGDEF domain
I6K35_RS15010	COG4114	ferric iron reductase
I6K35_RS15015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS15015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS15020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K35_RS15025	COG2197	response regulator
I6K35_RS15030	COG2197	response regulator
I6K35_RS15045	COG2966	Psort location CytoplasmicMembrane, score
I6K35_RS15060	COG1484	DNA-dependent DNA replication
I6K35_RS15075	COG5464	transposase or invertase
I6K35_RS15085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K35_RS15090	COG3716	PTS system mannose fructose sorbose family IID component
I6K35_RS15095	COG3715	PTS system
I6K35_RS15110	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS15110	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K35_RS15120	COG1063	alcohol dehydrogenase
I6K35_RS15125	COG1802	Transcriptional regulator
I6K35_RS15135	COG0456	acetyltransferase
I6K35_RS15135	COG1214	PFAM Peptidase M22, glycoprotease
I6K35_RS15145	COG1737	Transcriptional regulator
I6K35_RS15150	COG0800	Aldolase
I6K35_RS15155	COG3734	2-keto-3-deoxy-galactonokinase
I6K35_RS15170	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K35_RS15195	COG1846	Transcriptional regulator
I6K35_RS15205	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K35_RS15215	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS15220	COG3384	dioxygenase
I6K35_RS15230	COG3971	2-oxopent-4-enoate hydratase activity
I6K35_RS15250	COG2368	4-hydroxyphenylacetate
I6K35_RS15255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K35_RS15270	COG1966	Carbon starvation protein
I6K35_RS15275	COG2879	small protein
I6K35_RS15280	COG0523	cobalamin synthesis protein
I6K35_RS15290	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS15295	COG5464	transposase or invertase
I6K35_RS15300	COG2207	Transcriptional regulator
I6K35_RS15300	COG1917	Cupin 2, conserved barrel domain protein
I6K35_RS15310	COG2733	membrane
I6K35_RS15325	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K35_RS15330	COG1924	4 iron, 4 sulfur cluster binding
I6K35_RS15345	COG1566	PFAM secretion protein HlyD family protein
I6K35_RS15355	COG5457	Domain of unknown function (DUF1127)
I6K35_RS15360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K35_RS15370	COG0583	DNA-binding transcription factor activity
I6K35_RS15375	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K35_RS15385	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS15390	COG1129	ABC transporter
I6K35_RS15395	COG1879	ABC-type sugar transport system periplasmic component
I6K35_RS15405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS15410	COG0842	Transport permease protein
I6K35_RS15410	COG1129	ABC transporter
I6K35_RS15415	COG0842	Transport permease protein
I6K35_RS15445	COG2850	peptidyl-arginine hydroxylation
I6K35_RS15460	COG5002	protein histidine kinase activity
I6K35_RS15465	COG0745	RESPONSE REGULATOR receiver
I6K35_RS15470	COG1538	Outer membrane efflux protein
I6K35_RS15475	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS15480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS15485	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K35_RS15495	COG3040	lipid binding
I6K35_RS15500	COG0789	Transcriptional regulator
I6K35_RS15505	COG3631	Ketosteroid isomerase-related protein
I6K35_RS15510	COG0300	oxidoreductase activity
I6K35_RS15525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K35_RS15545	COG3272	Protein of unknown function (DUF1722)
I6K35_RS15555	COG4580	involved in the transport of maltose and maltodextrins
I6K35_RS15560	COG2115	Belongs to the xylose isomerase family
I6K35_RS15565	COG2211	Major facilitator Superfamily
I6K35_RS15570	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K35_RS15590	COG1216	Glycosyl transferase, family 2
I6K35_RS15680	COG0556	nucleotide-excision repair
I6K35_RS15695	COG0288	reversible hydration of carbon dioxide
I6K35_RS15700	COG0659	secondary active sulfate transmembrane transporter activity
I6K35_RS15705	COG1064	alcohol dehydrogenase
I6K35_RS15710	COG1175	transmembrane transport
I6K35_RS15715	COG0395	ABC-type sugar transport system, permease component
I6K35_RS15720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K35_RS15725	COG3842	ATPase activity
I6K35_RS15740	COG1082	Xylose isomerase domain protein TIM barrel
I6K35_RS15750	COG3962	Belongs to the TPP enzyme family
I6K35_RS15755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K35_RS15760	COG1737	Transcriptional regulator
I6K35_RS15760	COG0837	glucose binding
I6K35_RS15765	COG3718	enzyme involved in inositol metabolism
I6K35_RS15780	COG0433	COG0433 Predicted ATPase
I6K35_RS15785	COG0795	lipopolysaccharide-transporting ATPase activity
I6K35_RS15790	COG0795	lipopolysaccharide-transporting ATPase activity
I6K35_RS15800	COG2927	DNA polymerase III (CHI subunit)
I6K35_RS15805	COG0525	valine-tRNA ligase activity
I6K35_RS15830	COG2731	YhcH YjgK YiaL family protein
I6K35_RS15865	COG1263	PTS System
I6K35_RS15865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K35_RS15870	COG0366	Alpha amylase catalytic
I6K35_RS15875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS15880	COG1486	melibiose metabolic process
I6K35_RS15905	COG0602	queuosine metabolic process
I6K35_RS15910	COG2026	Addiction module toxin, RelE StbE family
I6K35_RS15915	COG3077	Addiction module antitoxin, RelB DinJ family
I6K35_RS15920	COG3711	transcriptional antiterminator
I6K35_RS15920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS15925	COG2706	6-phosphogluconolactonase activity
I6K35_RS15940	COG3964	amidohydrolase
I6K35_RS15980	COG0312	modulator of DNA gyrase
I6K35_RS16005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K35_RS16015	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS16020	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS16025	COG1129	ABC transporter
I6K35_RS16030	COG1879	ABC-type sugar transport system periplasmic component
I6K35_RS16045	COG2105	PFAM AIG2 family protein
I6K35_RS16050	COG2911	Protein conserved in bacteria
I6K35_RS16055	COG0729	surface antigen
I6K35_RS16065	COG1253	flavin adenine dinucleotide binding
I6K35_RS16090	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K35_RS16105	COG1733	regulation of RNA biosynthetic process
I6K35_RS16110	COG0702	epimerase
I6K35_RS16120	COG0697	spore germination
I6K35_RS16130	COG1113	amino acid transport
I6K35_RS16135	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K35_RS16140	COG3061	Opacity-associated protein A
I6K35_RS16150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K35_RS16155	COG2965	DNA replication, synthesis of RNA primer
I6K35_RS16215	COG1073	alpha beta
I6K35_RS16220	COG3650	response to hydrogen peroxide
I6K35_RS16230	COG1960	acyl-CoA dehydrogenase activity
I6K35_RS16235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K35_RS16240	COG0557	exoribonuclease II activity
I6K35_RS16255	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K35_RS16265	COG0330	HflC and HflK could
I6K35_RS16270	COG0330	HflC and HflK could
I6K35_RS16275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K35_RS16295	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K35_RS16300	COG0802	atpase or kinase
I6K35_RS16305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K35_RS16305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K35_RS16310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K35_RS16330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS16350	COG1511	domain protein
I6K35_RS16350	COG3264	Mechanosensitive ion channel
I6K35_RS16365	COG1053	succinate dehydrogenase
I6K35_RS16370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K35_RS16390	COG2076	Multidrug Resistance protein
I6K35_RS16395	COG5510	response to toxic substance
I6K35_RS16410	COG1509	lysine 2,3-aminomutase activity
I6K35_RS16475	COG0531	amino acid
I6K35_RS16480	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K35_RS16485	COG1027	Aspartate ammonia-lyase
I6K35_RS16490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K35_RS16505	COG1309	transcriptional regulator
I6K35_RS16535	COG0457	Tetratricopeptide repeat
I6K35_RS16540	COG1649	PFAM Uncharacterised BCR, COG1649
I6K35_RS16540	COG0726	polysaccharide deacetylase
I6K35_RS16545	COG1215	transferase activity, transferring glycosyl groups
I6K35_RS16560	COG0861	Integral membrane protein TerC family
I6K35_RS16600	COG1486	melibiose metabolic process
I6K35_RS16605	COG2169	Transcriptional regulator
I6K35_RS16615	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K35_RS16620	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K35_RS16625	COG2188	Transcriptional regulator
I6K35_RS16630	COG3624	Phosphonate C-P lyase system protein PhnG
I6K35_RS16635	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K35_RS16640	COG3626	phosphonate metabolism
I6K35_RS16645	COG3627	carbon phosphorus lyase activity
I6K35_RS16650	COG4107	phosphonate C-P lyase system protein PhnK
I6K35_RS16655	COG4778	phosphonate C-P lyase system protein PhnL
I6K35_RS16660	COG3454	Phosphonate metabolism
I6K35_RS16670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K35_RS16680	COG0784	Response regulator, receiver
I6K35_RS16680	COG4191	Histidine kinase
I6K35_RS16685	COG1129	ABC transporter
I6K35_RS16690	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS16725	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K35_RS16730	COG1301	dicarboxylic acid transport
I6K35_RS16740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K35_RS16745	COG3162	membrane
I6K35_RS16775	COG3539	Fimbrial protein
I6K35_RS16780	COG1346	cytolysis
I6K35_RS16785	COG1380	Effector of murein hydrolase LrgA
I6K35_RS16790	COG0583	DNA-binding transcription factor activity
I6K35_RS16795	COG0025	NhaP-type Na H and K H
I6K35_RS16800	COG2252	PERMEase
I6K35_RS16805	COG0625	glutathione transferase activity
I6K35_RS16810	COG0789	Transcriptional regulator
I6K35_RS16820	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K35_RS16850	COG1234	tRNA 3'-trailer cleavage
I6K35_RS16855	COG1609	Transcriptional regulator
I6K35_RS16860	COG0483	inositol monophosphate 1-phosphatase activity
I6K35_RS16870	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K35_RS16890	COG4771	TonB-dependent receptor
I6K35_RS16895	COG0741	lytic transglycosylase activity
I6K35_RS16910	COG2315	Protein conserved in bacteria
I6K35_RS16915	COG0432	Pfam Uncharacterised protein family UPF0047
I6K35_RS16930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K35_RS16935	COG0305	Participates in initiation and elongation during chromosome replication
I6K35_RS16950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K35_RS16960	COG0735	belongs to the Fur family
I6K35_RS16965	COG3237	CsbD-like
I6K35_RS16975	COG0534	Mate efflux family protein
I6K35_RS16985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K35_RS17055	COG0251	oxidation-reduction process
I6K35_RS17065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K35_RS17075	COG0527	aspartate kinase activity
I6K35_RS17125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K35_RS17135	COG0456	acetyltransferase
I6K35_RS17165	COG0151	Belongs to the GarS family
I6K35_RS17175	COG4191	Histidine kinase
I6K35_RS17180	COG3678	ATP-independent chaperone mediated protein folding
I6K35_RS17215	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K35_RS17230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K35_RS17235	COG2104	thiamine diphosphate biosynthetic process
I6K35_RS17250	COG3706	GGDEF domain
I6K35_RS17260	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K35_RS17265	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K35_RS17300	COG0250	Participates in transcription elongation, termination and antitermination
I6K35_RS17345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K35_RS17375	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K35_RS17385	COG1739	Uncharacterized protein family UPF0029
I6K35_RS17425	COG0805	protein transport
I6K35_RS17445	COG3165	ubiquinone biosynthetic process from chorismate
I6K35_RS17475	COG0583	DNA-binding transcription factor activity
I6K35_RS17480	COG0697	spore germination
I6K35_RS17485	COG0561	phosphatase activity
I6K35_RS17490	COG2267	carboxylic ester hydrolase activity
I6K35_RS17495	COG1280	lysine exporter protein (LysE YggA)
I6K35_RS17505	COG1280	lysine exporter protein (LysE YggA)
I6K35_RS17535	COG0210	DNA helicase
I6K35_RS17540	COG1011	Hydrolase
I6K35_RS17570	COG3072	Adenylate cyclase
I6K35_RS17585	COG2959	enzyme of heme biosynthesis
I6K35_RS17590	COG3071	HemY protein
I6K35_RS17635	COG2244	polysaccharide biosynthetic process
I6K35_RS17640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K35_RS17645	COG0456	acetyltransferase
I6K35_RS17650	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K35_RS17655	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K35_RS17660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K35_RS17665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K35_RS17675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K35_RS17680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K35_RS17685	COG3118	belongs to the thioredoxin family
I6K35_RS17710	COG1811	Na channel or pump
I6K35_RS17720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K35_RS17725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K35_RS17735	COG0583	DNA-binding transcription factor activity
I6K35_RS17740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K35_RS17755	COG3978	acetolactate synthase activity
I6K35_RS17780	COG3085	chromosome segregation
I6K35_RS17855	COG0583	DNA-binding transcription factor activity
I6K35_RS17870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K35_RS17885	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K35_RS17900	COG0371	Dehydrogenase
I6K35_RS17905	COG0697	spore germination
I6K35_RS17915	COG0583	DNA-binding transcription factor activity
I6K35_RS17925	COG0737	Belongs to the 5'-nucleotidase family
I6K35_RS17935	COG0460	homoserine dehydrogenase
I6K35_RS17935	COG0527	aspartate kinase activity
I6K35_RS17940	COG0626	cystathionine gamma-synthase activity
I6K35_RS17955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K35_RS17960	COG1609	Transcriptional regulator
I6K35_RS17965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K35_RS17980	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K35_RS18000	COG3678	ATP-independent chaperone mediated protein folding
I6K35_RS18005	COG0745	RESPONSE REGULATOR receiver
I6K35_RS18010	COG2205	protein histidine kinase activity
I6K35_RS18015	COG2258	MOSC domain
I6K35_RS18020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K35_RS18060	COG1129	ABC transporter
I6K35_RS18065	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS18070	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS18075	COG1454	alcohol dehydrogenase
I6K35_RS18085	COG2211	Major facilitator Superfamily
I6K35_RS18145	COG0205	6-phosphofructokinase activity
I6K35_RS18165	COG0437	4 iron, 4 sulfur cluster binding
I6K35_RS18170	COG2864	formate dehydrogenase
I6K35_RS18185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K35_RS18195	COG0456	acetyltransferase
I6K35_RS18210	COG1011	Hydrolase
I6K35_RS18225	COG3852	Histidine kinase
I6K35_RS18240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K35_RS18260	COG0204	Acyl-transferase
I6K35_RS18270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K35_RS18275	COG3084	Protein conserved in bacteria
I6K35_RS18285	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K35_RS18310	COG2186	Transcriptional regulator
I6K35_RS18315	COG0477	Major facilitator Superfamily
I6K35_RS18320	COG1609	Transcriptional regulator
I6K35_RS18325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K35_RS18335	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS18340	COG1129	ABC transporter
I6K35_RS18370	COG1522	sequence-specific DNA binding
I6K35_RS18375	COG0716	FMN binding
I6K35_RS18390	COG3312	ion transport
I6K35_RS18440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K35_RS18445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K35_RS18450	COG0573	inorganic phosphate transmembrane transporter activity
I6K35_RS18455	COG0581	inorganic phosphate transmembrane transporter activity
I6K35_RS18460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K35_RS18465	COG0704	Plays a role in the regulation of phosphate uptake
I6K35_RS18475	COG2382	esterase
I6K35_RS18480	COG0363	glucosamine-6-phosphate deaminase activity
I6K35_RS18485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K35_RS18490	COG2252	PERMEase
I6K35_RS18495	COG0431	NADPH-dependent FMN reductase
I6K35_RS18500	COG2091	lysine biosynthetic process via aminoadipic acid
I6K35_RS18530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K35_RS18560	COG0187	DNA topoisomerase II activity
I6K35_RS18565	COG0561	phosphatase activity
I6K35_RS18580	COG2186	Transcriptional regulator
I6K35_RS18585	COG3734	2-keto-3-deoxy-galactonokinase
I6K35_RS18590	COG0800	Aldolase
I6K35_RS18600	COG2271	Major facilitator Superfamily
I6K35_RS18605	COG0823	Involved in the tonB-independent uptake of proteins
I6K35_RS18610	COG5645	(Lipo)protein
I6K35_RS18625	COG3645	SOS response
I6K35_RS18635	COG2188	Transcriptional regulator
I6K35_RS18650	COG2149	membrane
I6K35_RS18670	COG2610	gluconate transmembrane transporter activity
I6K35_RS18680	COG0583	DNA-binding transcription factor activity
I6K35_RS18685	COG2814	Major facilitator Superfamily
I6K35_RS18715	COG0028	Belongs to the TPP enzyme family
I6K35_RS18720	COG0440	acetolactate synthase activity
I6K35_RS18725	COG2197	response regulator
I6K35_RS18735	COG2271	Major facilitator Superfamily
I6K35_RS18775	COG2188	Transcriptional regulator
I6K35_RS18800	COG4580	involved in the transport of maltose and maltodextrins
I6K35_RS18805	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K35_RS18810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS18810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS18820	COG1609	Transcriptional regulator
I6K35_RS18830	COG3384	dioxygenase
I6K35_RS18835	COG0583	DNA-binding transcription factor activity
I6K35_RS18840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K35_RS18845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K35_RS18850	COG2828	Protein conserved in bacteria
I6K35_RS18865	COG0697	spore germination
I6K35_RS18870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K35_RS18870	COG1263	PTS System
I6K35_RS18880	COG2814	Major facilitator Superfamily
I6K35_RS18890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K35_RS18925	COG0583	DNA-binding transcription factor activity
I6K35_RS18950	COG1464	Belongs to the NlpA lipoprotein family
I6K35_RS18965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K35_RS18975	COG1064	alcohol dehydrogenase
I6K35_RS19005	COG2211	Major facilitator Superfamily
I6K35_RS19010	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K35_RS19020	COG1486	melibiose metabolic process
I6K35_RS19025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K35_RS19025	COG1263	PTS System
I6K35_RS19030	COG2982	Protein involved in outer membrane biogenesis
I6K35_RS19035	COG2233	PERMEase
I6K35_RS19040	COG0786	glutamate:sodium symporter activity
I6K35_RS19060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K35_RS19085	COG3152	Membrane
I6K35_RS19095	COG1494	fructose-1,6-bisphosphatase
I6K35_RS19100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K35_RS19105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K35_RS19110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K35_RS19130	COG2860	membrane
I6K35_RS19140	COG2169	Transcriptional regulator
I6K35_RS19140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K35_RS19145	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K35_RS19150	COG1561	YicC-like family, N-terminal region
I6K35_RS19170	COG1131	(ABC) transporter
I6K35_RS19175	COG0842	Transport permease protein
I6K35_RS19200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K35_RS19235	COG1519	Transferase
I6K35_RS19240	COG1216	Glycosyl transferase, family 2
I6K35_RS19245	COG0438	transferase activity, transferring glycosyl groups
I6K35_RS19255	COG0859	PFAM glycosyl transferase family 9
I6K35_RS19265	COG1216	Glycosyl transferase, family 2
I6K35_RS19265	COG1442	glycosyl transferase family 8
I6K35_RS19270	COG3307	-O-antigen
I6K35_RS19275	COG0438	transferase activity, transferring glycosyl groups
I6K35_RS19280	COG0859	PFAM glycosyl transferase family 9
I6K35_RS19295	COG0156	8-amino-7-oxononanoate synthase activity
I6K35_RS19305	COG0463	Glycosyl transferase, family 2
I6K35_RS19310	COG2861	carbohydrate metabolic process
I6K35_RS19315	COG4942	peptidase
I6K35_RS19325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K35_RS19330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K35_RS19350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K35_RS19360	COG2186	Transcriptional regulator
I6K35_RS19380	COG3722	fumarate hydratase activity
I6K35_RS19400	COG0625	glutathione transferase activity
I6K35_RS19410	COG3276	selenocysteine insertion sequence binding
I6K35_RS19415	COG1414	Transcriptional regulator
I6K35_RS19420	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K35_RS19425	COG3977	Valine--pyruvate aminotransferase
I6K35_RS19430	COG0366	Alpha amylase catalytic
I6K35_RS19435	COG2992	FlgJ-related protein
I6K35_RS19440	COG2207	Transcriptional regulator
I6K35_RS19440	COG1609	Transcriptional regulator
I6K35_RS19445	COG4214	carbohydrate transport
I6K35_RS19455	COG4213	ABC transporter substrate-binding protein
I6K35_RS19470	COG4682	membrane
I6K35_RS19475	COG4682	membrane
I6K35_RS19480	COG3274	enterobacterial common antigen metabolic process
I6K35_RS19510	COG1278	Cold shock
I6K35_RS19515	COG2944	sequence-specific DNA binding
I6K35_RS19520	COG2814	Major facilitator Superfamily
I6K35_RS19540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K35_RS19550	COG1609	Transcriptional regulator
I6K35_RS19555	COG2885	chlorophyll binding
I6K35_RS19560	COG0243	molybdopterin cofactor binding
I6K35_RS19565	COG0456	acetyltransferase
I6K35_RS19570	COG2818	Glycosylase
I6K35_RS19575	COG5571	outer membrane autotransporter
I6K35_RS19580	COG2223	nitrite transmembrane transporter activity
I6K35_RS19605	COG0747	negative chemotaxis
I6K35_RS19610	COG0601	transmembrane transport
I6K35_RS19615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K35_RS19620	COG0444	Belongs to the ABC transporter superfamily
I6K35_RS19625	COG4608	Belongs to the ABC transporter superfamily
I6K35_RS19640	COG2894	cell division
I6K35_RS19650	COG1215	transferase activity, transferring glycosyl groups
I6K35_RS19655	COG0457	Tetratricopeptide repeat
I6K35_RS19670	COG2194	sulfuric ester hydrolase activity
I6K35_RS19700	COG1215	transferase activity, transferring glycosyl groups
I6K35_RS19705	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K35_RS19710	COG3118	belongs to the thioredoxin family
I6K35_RS19710	COG0457	Tetratricopeptide repeat
I6K35_RS19715	COG2200	EAL domain
I6K35_RS19715	COG2199	diguanylate cyclase activity
I6K35_RS19725	COG0612	Peptidase, M16
I6K35_RS19735	COG2982	Protein involved in outer membrane biogenesis
I6K35_RS19740	COG0477	Major facilitator Superfamily
I6K35_RS19745	COG1295	ribonuclease BN
I6K35_RS19750	COG0583	DNA-binding transcription factor activity
I6K35_RS19755	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS19760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K35_RS19770	COG1454	alcohol dehydrogenase
I6K35_RS19780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K35_RS19785	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K35_RS19790	COG0671	phosphoesterase, PA-phosphatase related
I6K35_RS19810	COG0589	response to stress
I6K35_RS19820	COG0306	phosphate transporter
I6K35_RS19825	COG2081	HI0933 family
I6K35_RS19830	COG2239	Acts as a magnesium transporter
I6K35_RS19845	COG1124	(ABC) transporter
I6K35_RS19855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K35_RS19860	COG0601	transmembrane transport
I6K35_RS19865	COG0747	negative chemotaxis
I6K35_RS19875	COG3479	Phenolic acid decarboxylase
I6K35_RS19915	COG0628	permease
I6K35_RS19920	COG0477	Major facilitator Superfamily
I6K35_RS19930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K35_RS19945	COG3714	YhhN family
I6K35_RS19955	COG3776	membrane
I6K35_RS19960	COG0742	ribosomal rna small subunit methyltransferase
I6K35_RS19965	COG0552	protein localization to endoplasmic reticulum
I6K35_RS19970	COG2884	Cell division ATP-binding protein ftsE
I6K35_RS19975	COG2177	Part of the ABC transporter FtsEX involved in
I6K35_RS19990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K35_RS20000	COG0683	leucine binding
I6K35_RS20010	COG0683	leucine binding
I6K35_RS20015	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K35_RS20065	COG0584	glycerophosphoryl diester phosphodiesterase
I6K35_RS20075	COG0405	Gamma-glutamyltransferase
I6K35_RS20080	COG1247	-acetyltransferase
I6K35_RS20090	COG0673	inositol 2-dehydrogenase activity
I6K35_RS20095	COG1741	Belongs to the pirin family
I6K35_RS20100	COG1609	Transcriptional regulator
I6K35_RS20105	COG3265	gluconokinase activity
I6K35_RS20110	COG2610	gluconate transmembrane transporter activity
I6K35_RS20120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K35_RS20145	COG0058	SHG alpha-glucan phosphorylase activity
I6K35_RS20150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K35_RS20165	COG1349	DNA-binding transcription factor activity
I6K35_RS20175	COG0058	SHG alpha-glucan phosphorylase activity
I6K35_RS20180	COG1640	4-alpha-glucanotransferase
I6K35_RS20185	COG2610	gluconate transmembrane transporter activity
I6K35_RS20195	COG1040	competence protein
I6K35_RS20220	COG1918	ferrous iron import across plasma membrane
I6K35_RS20225	COG2183	response to ionizing radiation
I6K35_RS20230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K35_RS20255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K35_RS20260	COG1011	Hydrolase
I6K35_RS20270	COG0494	nUDIX hydrolase
I6K35_RS20275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K35_RS20300	COG4796	Type ii and iii secretion system protein
I6K35_RS20315	COG3266	domain, Protein
I6K35_RS20320	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K35_RS20325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K35_RS20350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K35_RS20355	COG0402	S-adenosylhomocysteine deaminase activity
I6K35_RS20360	COG0738	Major facilitator superfamily
I6K35_RS20385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K35_RS20390	COG1289	transmembrane transporter activity
I6K35_RS20400	COG1765	OsmC-like protein
I6K35_RS20405	COG3954	Phosphoribulokinase
I6K35_RS20415	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K35_RS20420	COG0488	(ABC) transporter
I6K35_RS20435	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K35_RS20440	COG1047	Peptidyl-prolyl cis-trans
I6K35_RS20450	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K35_RS20455	COG2964	Protein conserved in bacteria
I6K35_RS20510	COG0051	transcription antitermination factor activity, RNA binding
I6K35_RS20535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K35_RS20550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K35_RS20615	COG0201	protein transport
I6K35_RS20640	COG0202	RNA polymerase activity
I6K35_RS20655	COG0789	Transcriptional regulator
I6K35_RS20660	COG3036	rescue of stalled ribosome
I6K35_RS20690	COG0758	DNA mediated transformation
I6K35_RS20700	COG0551	DNA topoisomerase type I activity
I6K35_RS20720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K35_RS20755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K35_RS20760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS20770	COG1309	transcriptional regulator
I6K35_RS20790	COG4145	pantothenate transmembrane transporter activity
I6K35_RS20795	COG3924	membrane
I6K35_RS20800	COG0439	Biotin carboxylase
I6K35_RS20805	COG0511	ligase activity, forming carbon-carbon bonds
I6K35_RS20830	COG2199	diguanylate cyclase activity
I6K35_RS20830	COG2200	EAL domain
I6K35_RS20835	COG1077	Cell shape determining protein MreB Mrl
I6K35_RS20840	COG1792	Involved in formation and maintenance of cell shape
I6K35_RS20845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K35_RS20855	COG1530	ribonuclease E activity
I6K35_RS20860	COG3164	Protein of unknown function
I6K35_RS20865	COG0312	modulator of DNA gyrase
I6K35_RS20870	COG0583	DNA-binding transcription factor activity
I6K35_RS20885	COG1289	transmembrane transporter activity
I6K35_RS20890	COG2732	(Barnase) inhibitor
I6K35_RS20925	COG0471	metal ion transport
I6K35_RS20930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K35_RS20935	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K35_RS20960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K35_RS20965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K35_RS20970	COG3105	Protein conserved in bacteria
I6K35_RS20975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K35_RS20995	COG0625	glutathione transferase activity
I6K35_RS21000	COG2969	positive regulation of protein catabolic process
I6K35_RS21010	COG0493	'glutamate synthase
I6K35_RS21015	COG0070	glutamate synthase
I6K35_RS21015	COG0069	glutamate synthase activity
I6K35_RS21015	COG0067	glutamate synthase
I6K35_RS21020	COG1242	4 iron, 4 sulfur cluster binding
I6K35_RS21025	COG2271	Major facilitator Superfamily
I6K35_RS21030	COG1063	alcohol dehydrogenase
I6K35_RS21035	COG1312	Catalyzes the dehydration of D-mannonate
I6K35_RS21040	COG5002	protein histidine kinase activity
I6K35_RS21040	COG2198	Histidine kinase
I6K35_RS21040	COG0784	Response regulator, receiver
I6K35_RS21045	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K35_RS21050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K35_RS21055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS21065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS21070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K35_RS21075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K35_RS21080	COG1137	ATPase activity
I6K35_RS21085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K35_RS21090	COG3117	lipopolysaccharide transmembrane transporter activity
I6K35_RS21095	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K35_RS21105	COG0530	calcium, potassium:sodium antiporter activity
I6K35_RS21110	COG1127	ABC transporter
I6K35_RS21115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K35_RS21120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K35_RS21125	COG2854	intermembrane phospholipid transfer
I6K35_RS21130	COG3113	response to antibiotic
I6K35_RS21135	COG5007	Belongs to the BolA IbaG family
I6K35_RS21145	COG3423	Transcriptional regulator
I6K35_RS21150	COG0142	geranyltranstransferase activity
I6K35_RS21165	COG0697	spore germination
I6K35_RS21175	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K35_RS21185	COG1534	Rna-binding protein
I6K35_RS21195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K35_RS21200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K35_RS21210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K35_RS21250	COG0195	Participates in both transcription termination and antitermination
I6K35_RS21295	COG0814	amino acid
I6K35_RS21300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K35_RS21305	COG0826	peptidase U32
I6K35_RS21310	COG0826	peptidase U32
I6K35_RS21315	COG3154	lipid carrier protein
I6K35_RS21320	COG3153	acetyltransferase
I6K35_RS21335	COG0693	protein deglycase activity
I6K35_RS21340	COG0702	epimerase
I6K35_RS21345	COG0701	Predicted permease
I6K35_RS21350	COG2823	Periplasmic or secreted lipoprotein
I6K35_RS21370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K35_RS21375	COG2721	sulfolactate sulfo-lyase activity
I6K35_RS21380	COG2271	Major facilitator Superfamily
I6K35_RS21390	COG2084	Dehydrogenase
I6K35_RS21395	COG1929	Belongs to the glycerate kinase type-1 family
I6K35_RS21420	COG1741	Belongs to the pirin family
I6K35_RS21425	COG0583	DNA-binding transcription factor activity
I6K35_RS21430	COG3152	Membrane
I6K35_RS21435	COG0435	Glutathione S-transferase
I6K35_RS21440	COG2259	Doxx family
I6K35_RS21450	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K35_RS21455	COG4575	ribosome binding
I6K35_RS21460	COG1422	Protein of unknown function (DUF1090)
I6K35_RS21470	COG0586	Pfam SNARE associated Golgi protein
I6K35_RS21475	COG2186	Transcriptional regulator
I6K35_RS21480	COG2271	Major facilitator Superfamily
I6K35_RS21490	COG2721	sulfolactate sulfo-lyase activity
I6K35_RS21505	COG0861	Integral membrane protein TerC family
I6K35_RS21510	COG0673	inositol 2-dehydrogenase activity
I6K35_RS21515	COG1451	nucleotide metabolic process
I6K35_RS21535	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K35_RS21535	COG1902	pentaerythritol trinitrate reductase activity
I6K35_RS21585	COG1695	Transcriptional regulator
I6K35_RS21590	COG2375	cellular response to nickel ion
I6K35_RS21605	COG1461	Dihydroxyacetone kinase
I6K35_RS21610	COG2376	Dihydroxyacetone kinase
I6K35_RS21680	COG3247	response to pH
I6K35_RS21690	COG0784	Response regulator, receiver
I6K35_RS21690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS21690	COG2198	Histidine kinase
I6K35_RS21690	COG2205	protein histidine kinase activity
I6K35_RS21695	COG2197	response regulator
I6K35_RS21720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K35_RS21725	COG0358	DNA primase activity
I6K35_RS21730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K35_RS21795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K35_RS21810	COG4991	sh3 domain protein
I6K35_RS21815	COG3025	triphosphatase activity
I6K35_RS21840	COG2960	long-chain fatty acid transporting porin activity
I6K35_RS21855	COG3384	dioxygenase
I6K35_RS21860	COG0754	glutathionylspermidine amidase activity
I6K35_RS21875	COG0494	nUDIX hydrolase
I6K35_RS21880	COG3151	Protein conserved in bacteria
I6K35_RS21885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K35_RS21890	COG3150	esterase
I6K35_RS21900	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K35_RS21905	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K35_RS21910	COG0642	Histidine kinase
I6K35_RS21920	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K35_RS21925	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K35_RS21930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K35_RS21935	COG0204	Acyl-transferase
I6K35_RS21940	COG2132	Multicopper oxidase
I6K35_RS21945	COG1032	radical SAM domain protein
I6K35_RS21955	COG0656	L-ascorbic acid biosynthetic process
I6K35_RS21960	COG1979	alcohol dehydrogenase
I6K35_RS21965	COG2207	Transcriptional regulator
I6K35_RS21970	COG0586	Pfam SNARE associated Golgi protein
I6K35_RS21975	COG0626	cystathionine gamma-synthase activity
I6K35_RS21985	COG0848	biopolymer transport protein
I6K35_RS21990	COG2211	Major facilitator Superfamily
I6K35_RS22015	COG0625	glutathione transferase activity
I6K35_RS22030	COG0754	glutathionylspermidine amidase activity
I6K35_RS22035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K35_RS22055	COG0583	DNA-binding transcription factor activity
I6K35_RS22060	COG0626	cystathionine gamma-synthase activity
I6K35_RS22090	COG1811	Na channel or pump
I6K35_RS22095	COG1982	Orn Lys Arg decarboxylase major
I6K35_RS22100	COG2211	Major facilitator Superfamily
I6K35_RS22115	COG1194	a g-specific adenine glycosylase
I6K35_RS22125	COG3171	Protein conserved in bacteria
I6K35_RS22135	COG4214	carbohydrate transport
I6K35_RS22150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K35_RS22165	COG0762	integral membrane protein
I6K35_RS22170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K35_RS22175	COG2805	Type II/IV secretion system protein
I6K35_RS22195	COG0189	ligase activity
I6K35_RS22200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K35_RS22205	COG2356	endonuclease I
I6K35_RS22215	COG2814	Major facilitator Superfamily
I6K35_RS22250	COG2146	nitrite reductase [NAD(P)H] activity
I6K35_RS22265	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS22270	COG1414	Transcriptional regulator
I6K35_RS22300	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS22305	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K35_RS22325	COG0501	Belongs to the peptidase M48B family
I6K35_RS22330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K35_RS22345	COG0191	fructose-bisphosphate aldolase activity
I6K35_RS22350	COG0668	transmembrane transport
I6K35_RS22360	COG2968	Membrane
I6K35_RS22375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K35_RS22380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K35_RS22400	COG0006	proline dipeptidase activity
I6K35_RS22405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K35_RS22410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K35_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS22435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K35_RS22455	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS22460	COG1737	Transcriptional regulator
I6K35_RS22470	COG1272	protein, Hemolysin III
I6K35_RS22480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K35_RS22490	COG0716	FMN binding
I6K35_RS22495	COG4974	Belongs to the 'phage' integrase family
I6K35_RS22505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K35_RS22525	COG1811	Na channel or pump
I6K35_RS22535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K35_RS22540	COG0583	DNA-binding transcription factor activity
I6K35_RS22545	COG4942	peptidase
I6K35_RS22555	COG0582	viral genome integration into host DNA
I6K35_RS22630	COG2814	Major facilitator Superfamily
I6K35_RS22645	COG0667	Aldo Keto reductase
I6K35_RS22685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K35_RS22690	COG1393	Belongs to the ArsC family
I6K35_RS22705	COG1538	Outer membrane efflux protein
I6K35_RS22710	COG1289	transmembrane transporter activity
I6K35_RS22725	COG3592	Divergent 4Fe-4S mono-cluster
I6K35_RS22730	COG2388	GCN5-related N-acetyl-transferase
I6K35_RS22740	COG3539	Fimbrial protein
I6K35_RS22745	COG3539	Fimbrial protein
I6K35_RS22750	COG3539	Fimbrial protein
I6K35_RS22755	COG3188	usher protein
I6K35_RS22760	COG3121	Chaperone
I6K35_RS22765	COG3539	Fimbrial protein
I6K35_RS22775	COG4974	Belongs to the 'phage' integrase family
I6K35_RS22780	COG0582	viral genome integration into host DNA
I6K35_RS22785	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K35_RS22790	COG1846	Transcriptional regulator
I6K35_RS22795	COG0697	spore germination
I6K35_RS22845	COG0667	Aldo Keto reductase
I6K35_RS22850	COG0814	amino acid
I6K35_RS22865	COG0183	Belongs to the thiolase family
I6K35_RS22875	COG0823	Involved in the tonB-independent uptake of proteins
I6K35_RS22880	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS22885	COG2814	Major facilitator Superfamily
I6K35_RS22920	COG3842	ATPase activity
I6K35_RS22925	COG0395	ABC-type sugar transport system, permease component
I6K35_RS22930	COG1175	transmembrane transport
I6K35_RS22935	COG1917	Cupin 2, conserved barrel domain protein
I6K35_RS22940	COG1794	racemase activity, acting on amino acids and derivatives
I6K35_RS22945	COG0583	DNA-binding transcription factor activity
I6K35_RS22955	COG1609	Transcriptional regulator
I6K35_RS22960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS22965	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS22970	COG2186	Transcriptional regulator
I6K35_RS22980	COG1609	Transcriptional regulator
I6K35_RS23000	COG0667	Aldo Keto reductase
I6K35_RS23010	COG0861	Integral membrane protein TerC family
I6K35_RS23045	COG2165	general secretion pathway protein
I6K35_RS23050	COG4795	General secretion pathway protein
I6K35_RS23060	COG4967	type IV pilus modification protein PilV
I6K35_RS23065	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K35_RS23070	COG1025	Belongs to the peptidase M16 family
I6K35_RS23075	COG1074	ATP-dependent DNA helicase activity
I6K35_RS23080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K35_RS23090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K35_RS23090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K35_RS23095	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K35_RS23100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K35_RS23130	COG4656	Part of a membrane complex involved in electron transport
I6K35_RS23135	COG1454	alcohol dehydrogenase
I6K35_RS23135	COG1012	belongs to the aldehyde dehydrogenase family
I6K35_RS23165	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K35_RS23330	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K35_RS23335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K35_RS23340	COG2166	iron-sulfur cluster assembly
I6K35_RS23345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K35_RS23355	COG0583	DNA-binding transcription factor activity
I6K35_RS23360	COG2363	Small membrane protein
I6K35_RS23370	COG1349	DNA-binding transcription factor activity
I6K35_RS23390	COG0738	Major facilitator superfamily
I6K35_RS23395	COG0235	Class ii aldolase
I6K35_RS23400	COG1454	alcohol dehydrogenase
I6K35_RS23420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K35_RS23435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K35_RS23440	COG2011	ABC-type metal ion transport system permease component
I6K35_RS23445	COG1464	Belongs to the NlpA lipoprotein family
I6K35_RS23450	COG0477	Major facilitator Superfamily
I6K35_RS23460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K35_RS23465	COG1760	l-serine dehydratase
I6K35_RS23470	COG0814	amino acid
I6K35_RS23475	COG1611	Belongs to the LOG family
I6K35_RS23490	COG3098	single-species biofilm formation
I6K35_RS23495	COG0564	pseudouridine synthase activity
I6K35_RS23500	COG0716	FMN binding
I6K35_RS23505	COG2271	Major facilitator Superfamily
I6K35_RS23510	COG4948	Mandelate Racemase Muconate Lactonizing
I6K35_RS23515	COG4948	Mandelate Racemase Muconate Lactonizing
I6K35_RS23520	COG1929	Belongs to the glycerate kinase type-1 family
I6K35_RS23525	COG2205	protein histidine kinase activity
I6K35_RS23525	COG3850	Histidine kinase
I6K35_RS23525	COG4999	Histidine kinase
I6K35_RS23525	COG3437	response regulator, receiver
I6K35_RS23535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K35_RS23540	COG3956	TIGRFAM MazG family protein
I6K35_RS23560	COG0602	queuosine metabolic process
I6K35_RS23565	COG0720	synthase
I6K35_RS23585	COG2234	aminopeptidase activity
I6K35_RS23645	COG4942	peptidase
I6K35_RS23645	COG1388	LysM domain
I6K35_RS23650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K35_RS23675	COG0163	prenyltransferase activity
I6K35_RS23680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K35_RS23705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K35_RS23710	COG4558	Periplasmic binding protein
I6K35_RS23715	COG3720	iron ion transport
I6K35_RS23735	COG0679	Auxin Efflux Carrier
I6K35_RS23750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K35_RS23755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K35_RS23760	COG1121	(ABC) transporter
I6K35_RS23770	COG1609	Transcriptional regulator
I6K35_RS23775	COG1940	carbohydrate kinase activity
I6K35_RS23780	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K35_RS23785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS23790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS23795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K35_RS23800	COG4580	involved in the transport of maltose and maltodextrins
I6K35_RS23810	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS23820	COG0309	Hydrogenase expression formation protein (HypE)
I6K35_RS23825	COG0409	Hydrogenase expression formation protein
I6K35_RS23830	COG0298	carbon dioxide binding
I6K35_RS23835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K35_RS23850	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K35_RS23855	COG0651	ATP synthesis coupled electron transport
I6K35_RS23860	COG0650	Formate hydrogenlyase subunit 4
I6K35_RS23865	COG3261	NADH dehydrogenase
I6K35_RS23865	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K35_RS23870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K35_RS23875	COG3260	NADH ubiquinone oxidoreductase 20
I6K35_RS23885	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K35_RS23895	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS23900	COG1263	PTS System
I6K35_RS23900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K35_RS23905	COG1609	Transcriptional regulator
I6K35_RS23910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K35_RS23915	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K35_RS23920	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K35_RS23945	COG1349	DNA-binding transcription factor activity
I6K35_RS23950	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS23955	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS23965	COG3732	PTS system glucitol sorbitol-specific
I6K35_RS23970	COG3730	PTS system glucitol sorbitol-specific
I6K35_RS23975	COG2951	lytic endotransglycosylase activity
I6K35_RS23980	COG1121	(ABC) transporter
I6K35_RS23985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K35_RS23995	COG1546	Belongs to the CinA family
I6K35_RS24015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K35_RS24045	COG2823	Periplasmic or secreted lipoprotein
I6K35_RS24050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K35_RS24055	COG1238	metal cluster binding
I6K35_RS24075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K35_RS24080	COG2814	Major facilitator Superfamily
I6K35_RS24085	COG1566	PFAM secretion protein HlyD family protein
I6K35_RS24090	COG1846	Transcriptional regulator
I6K35_RS24100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K35_RS24110	COG4176	ABC-type proline glycine betaine transport system permease component
I6K35_RS24125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K35_RS24135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K35_RS24140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K35_RS24145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K35_RS24150	COG4575	ribosome binding
I6K35_RS24165	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K35_RS24180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K35_RS24185	COG0640	Transcriptional regulator
I6K35_RS24195	COG0583	DNA-binding transcription factor activity
I6K35_RS24200	COG3284	Transcriptional regulator
I6K35_RS24210	COG3539	Fimbrial protein
I6K35_RS24215	COG3121	Chaperone
I6K35_RS24235	COG3188	usher protein
I6K35_RS24245	COG3539	Fimbrial protein
I6K35_RS24250	COG2197	response regulator
I6K35_RS24270	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS24280	COG0235	Class ii aldolase
I6K35_RS24290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS24325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K35_RS24330	COG3708	Transcriptional regulator
I6K35_RS24330	COG2207	Transcriptional regulator
I6K35_RS24410	COG0582	viral genome integration into host DNA
I6K35_RS24425	COG2867	negative regulation of translational initiation
I6K35_RS24440	COG0497	DNA recombination
I6K35_RS24455	COG4536	flavin adenine dinucleotide binding
I6K35_RS24460	COG4137	Cytochrome C assembly protein
I6K35_RS24465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K35_RS24500	COG2885	chlorophyll binding
I6K35_RS24505	COG2199	diguanylate cyclase activity
I6K35_RS24515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K35_RS24520	COG1605	Chorismate mutase
I6K35_RS24520	COG0287	Prephenate dehydrogenase
I6K35_RS24530	COG0077	Prephenate dehydratase
I6K35_RS24530	COG1605	Chorismate mutase
I6K35_RS24540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K35_RS24545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K35_RS24560	COG0542	response to heat
I6K35_RS24585	COG0477	Major facilitator Superfamily
I6K35_RS24590	COG5544	Lipoprotein
I6K35_RS24595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K35_RS24605	COG3148	PFAM DTW domain containing protein
I6K35_RS24610	COG3118	belongs to the thioredoxin family
I6K35_RS24615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K35_RS24630	COG0513	Belongs to the DEAD box helicase family
I6K35_RS24640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K35_RS24655	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K35_RS24660	COG3026	antisigma factor binding
I6K35_RS24665	COG3086	response to oxidative stress
I6K35_RS24675	COG0681	Belongs to the peptidase S26 family
I6K35_RS24695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K35_RS24705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K35_RS24710	COG1737	Transcriptional regulator
I6K35_RS24715	COG0560	Phosphoserine phosphatase
I6K35_RS24730	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K35_RS24730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K35_RS24735	COG2205	protein histidine kinase activity
I6K35_RS24740	COG3170	Tfp pilus assembly protein FimV
I6K35_RS24745	COG2204	response regulator
I6K35_RS24750	COG0347	Belongs to the P(II) protein family
I6K35_RS24755	COG1017	nitric oxide dioxygenase activity
I6K35_RS24755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K35_RS24765	COG2259	Doxx family
I6K35_RS24770	COG1940	carbohydrate kinase activity
I6K35_RS24775	COG0457	Tetratricopeptide repeat
I6K35_RS24780	COG2814	Major facilitator Superfamily
I6K35_RS24780	COG0477	Major facilitator Superfamily
I6K35_RS24785	COG2017	converts alpha-aldose to the beta-anomer
I6K35_RS24790	COG2814	Major facilitator Superfamily
I6K35_RS24795	COG3711	transcriptional antiterminator
I6K35_RS24800	COG3683	transport system, periplasmic component
I6K35_RS24805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K35_RS24835	COG0822	iron-sulfur transferase activity
I6K35_RS24855	COG0633	Ferredoxin
I6K35_RS24860	COG2975	iron-sulfur cluster assembly
I6K35_RS24880	COG2897	thiosulfate sulfurtransferase activity
I6K35_RS24885	COG2373	Large extracellular alpha-helical protein
I6K35_RS24890	COG4953	penicillin-binding protein 1C
I6K35_RS24920	COG2976	Protein conserved in bacteria
I6K35_RS24940	COG1645	bacterial-type flagellum-dependent swarming motility
I6K35_RS24950	COG0516	GMP reductase activity
I6K35_RS24950	COG0517	IMP dehydrogenase activity
I6K35_RS24960	COG3119	arylsulfatase activity
I6K35_RS24965	COG0641	radical SAM
I6K35_RS24985	COG2200	EAL domain
I6K35_RS25000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K35_RS25015	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS25025	COG2233	PERMEase
I6K35_RS25040	COG1393	Belongs to the ArsC family
I6K35_RS25045	COG4783	chaperone-mediated protein folding
I6K35_RS25055	COG0628	permease
I6K35_RS25060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K35_RS25065	COG2716	regulation of RNA biosynthetic process
I6K35_RS25075	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K35_RS25085	COG2321	neutral zinc metallopeptidase
I6K35_RS25090	COG1444	tRNA N-acetyltransferase activity
I6K35_RS25095	COG0400	carboxylic ester hydrolase activity
I6K35_RS25110	COG1393	Belongs to the ArsC family
I6K35_RS25120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K35_RS25125	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K35_RS25125	COG0493	'glutamate synthase
I6K35_RS25135	COG5342	invasion associated locus B
I6K35_RS25140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K35_RS25145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K35_RS25155	COG4810	utilization protein
I6K35_RS25245	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K35_RS25265	COG2837	iron assimilation
I6K35_RS25275	COG4150	thiosulfate binding
I6K35_RS25280	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K35_RS25285	COG4208	sulfate ABC transporter
I6K35_RS25290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K35_RS25300	COG4319	ketosteroid isomerase
I6K35_RS25335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K35_RS25355	COG3530	Putative quorum-sensing-regulated virulence factor
I6K35_RS25360	COG0385	Bile acid
I6K35_RS25365	COG0583	DNA-binding transcription factor activity
I6K35_RS25400	COG3415	Transposase
I6K35_RS25405	COG3415	Transposase
I6K35_RS25420	COG2199	diguanylate cyclase activity
I6K35_RS25420	COG2200	EAL domain
I6K35_RS25425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K35_RS25440	COG0667	Aldo Keto reductase
I6K35_RS25445	COG3961	Belongs to the TPP enzyme family
I6K35_RS25460	COG3279	Response regulator of the LytR AlgR family
I6K35_RS25465	COG3275	phosphorelay sensor kinase activity
I6K35_RS25480	COG0436	Aminotransferase
I6K35_RS25490	COG2807	transmembrane transport
I6K35_RS25495	COG0590	tRNA wobble adenosine to inosine editing
I6K35_RS25500	COG0583	DNA-binding transcription factor activity
I6K35_RS25520	COG2116	formate transmembrane transporter activity
I6K35_RS25525	COG2853	Lipoprotein
I6K35_RS25535	COG3691	Protein conserved in bacteria
I6K35_RS25550	COG2062	phosphohistidine phosphatase, SixA
I6K35_RS25575	COG0730	response to heat
I6K35_RS25580	COG3101	peptidyl-lysine hydroxylation
I6K35_RS25595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K35_RS25615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K35_RS25625	COG0586	Pfam SNARE associated Golgi protein
I6K35_RS25635	COG0285	dihydrofolate synthase activity
I6K35_RS25640	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K35_RS25645	COG1286	toxin biosynthetic process
I6K35_RS25650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K35_RS25655	COG0163	prenyltransferase activity
I6K35_RS25680	COG4160	amino acid transport
I6K35_RS25685	COG4598	ABC transporter
I6K35_RS25700	COG1090	epimerase
I6K35_RS25705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K35_RS25710	COG0625	glutathione transferase activity
I6K35_RS25715	COG0625	glutathione transferase activity
I6K35_RS25720	COG0622	Phosphoesterase
I6K35_RS25725	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K35_RS25730	COG0280	phosphate acetyltransferase
I6K35_RS25730	COG0857	belongs to the CobB CobQ family
I6K35_RS25750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K35_RS25755	COG0490	domain, Protein
I6K35_RS25755	COG0471	metal ion transport
I6K35_RS25765	COG0436	Aminotransferase
I6K35_RS25770	COG0583	DNA-binding transcription factor activity
I6K35_RS25815	COG0839	Belongs to the complex I subunit 6 family
I6K35_RS25825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K35_RS25830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K35_RS25845	COG2153	protein acetylation
I6K35_RS25850	COG1169	isochorismate synthase
I6K35_RS25875	COG0318	PFAM AMP-dependent synthetase and ligase
I6K35_RS25885	COG5464	transposase or invertase
I6K35_RS25900	COG1414	Transcriptional regulator
I6K35_RS25910	COG2271	Major facilitator Superfamily
I6K35_RS25920	COG0247	lactate metabolic process
I6K35_RS25930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K35_RS25935	COG2271	Major facilitator Superfamily
I6K35_RS25940	COG0584	glycerophosphoryl diester phosphodiesterase
I6K35_RS25945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K35_RS25970	COG0784	Response regulator, receiver
I6K35_RS25970	COG2205	protein histidine kinase activity
I6K35_RS25980	COG0642	Histidine kinase
I6K35_RS25980	COG2198	Histidine kinase
I6K35_RS25995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K35_RS25995	COG2169	Transcriptional regulator
I6K35_RS26000	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K35_RS26005	COG4615	Cyclic peptide transporter
I6K35_RS26010	COG2239	Acts as a magnesium transporter
I6K35_RS26015	COG0659	secondary active sulfate transmembrane transporter activity
I6K35_RS26030	COG0628	permease
I6K35_RS26055	COG1349	DNA-binding transcription factor activity
I6K35_RS26060	COG0494	nUDIX hydrolase
I6K35_RS26080	COG1061	Type III restriction enzyme res subunit
I6K35_RS26085	COG1187	pseudouridine synthase activity
I6K35_RS26090	COG2814	Major facilitator Superfamily
I6K35_RS26100	COG4172	Belongs to the ABC transporter superfamily
I6K35_RS26105	COG4239	(ABC) transporter, permease
I6K35_RS26110	COG4174	ABC transporter (Permease)
I6K35_RS26115	COG4166	transmembrane transport
I6K35_RS26120	COG2200	EAL domain
I6K35_RS26125	COG0791	NLP P60 protein
I6K35_RS26130	COG0671	phosphoesterase, PA-phosphatase related
I6K35_RS26135	COG0523	cobalamin synthesis protein
I6K35_RS26140	COG0246	Mannitol dehydrogenase
I6K35_RS26145	COG1312	Catalyzes the dehydration of D-mannonate
I6K35_RS26160	COG2814	Major facilitator Superfamily
I6K35_RS26165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS26165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K35_RS26170	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K35_RS26175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K35_RS26175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K35_RS26175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K35_RS26185	COG2855	membrane
I6K35_RS26190	COG0583	DNA-binding transcription factor activity
I6K35_RS26195	COG0833	amino acid
I6K35_RS26200	COG4771	TonB-dependent receptor
I6K35_RS26215	COG2311	Membrane
I6K35_RS26230	COG1129	ABC transporter
I6K35_RS26240	COG2949	membrane
I6K35_RS26250	COG1346	cytolysis
I6K35_RS26260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K35_RS26265	COG3659	wide pore channel activity
I6K35_RS26280	COG2723	6-phospho-beta-galactosidase activity
I6K35_RS26285	COG1538	Outer membrane efflux protein
I6K35_RS26290	COG0586	Pfam SNARE associated Golgi protein
I6K35_RS26300	COG1686	Belongs to the peptidase S11 family
I6K35_RS26310	COG0277	FAD linked oxidase domain protein
I6K35_RS26315	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K35_RS26320	COG1732	Glycine betaine
I6K35_RS26325	COG1174	glycine betaine transport
I6K35_RS26330	COG1125	glycine betaine transport
I6K35_RS26335	COG1174	glycine betaine transport
I6K35_RS26345	COG3275	phosphorelay sensor kinase activity
I6K35_RS26355	COG4807	Protein conserved in bacteria
I6K35_RS26375	COG5455	response to cobalt ion
I6K35_RS26380	COG0583	DNA-binding transcription factor activity
I6K35_RS26385	COG2252	PERMEase
I6K35_RS26395	COG0583	DNA-binding transcription factor activity
I6K35_RS26485	COG0351	phosphomethylpyrimidine kinase
I6K35_RS26490	COG1830	Aldolase
I6K35_RS26525	COG1070	Carbohydrate kinase
I6K35_RS26535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K35_RS26540	COG4948	Mandelate Racemase Muconate Lactonizing
I6K35_RS26545	COG0747	negative chemotaxis
I6K35_RS26550	COG0601	transmembrane transport
I6K35_RS26555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K35_RS26560	COG0444	Belongs to the ABC transporter superfamily
I6K35_RS26565	COG4608	Belongs to the ABC transporter superfamily
I6K35_RS26575	COG0826	peptidase U32
I6K35_RS26580	COG0745	RESPONSE REGULATOR receiver
I6K35_RS26585	COG2205	protein histidine kinase activity
I6K35_RS26610	COG1301	dicarboxylic acid transport
I6K35_RS26635	COG0443	Heat shock 70 kDa protein
I6K35_RS26640	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K35_RS26655	COG2982	Protein involved in outer membrane biogenesis
I6K35_RS26660	COG1253	flavin adenine dinucleotide binding
I6K35_RS26735	COG1215	transferase activity, transferring glycosyl groups
I6K35_RS26805	COG3039	Transposase
I6K35_RS26815	COG0438	transferase activity, transferring glycosyl groups
I6K35_RS26820	COG1215	transferase activity, transferring glycosyl groups
I6K35_RS26840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K35_RS26870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K35_RS26875	COG0583	DNA-binding transcription factor activity
I6K35_RS26885	COG0531	amino acid
I6K35_RS26890	COG0640	Transcriptional regulator
I6K35_RS26895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K35_RS26900	COG2925	Exonuclease
I6K35_RS26915	COG1289	transmembrane transporter activity
I6K35_RS26935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K35_RS26945	COG1942	4-Oxalocrotonate Tautomerase
I6K35_RS26950	COG0583	DNA-binding transcription factor activity
I6K35_RS26955	COG0095	Lipoate-protein ligase
I6K35_RS26960	COG0477	Major facilitator Superfamily
I6K35_RS26970	COG3300	MHYT domain
I6K35_RS26970	COG5001	Diguanylate cyclase
I6K35_RS26980	COG3615	Tellurite resistance protein tehB
I6K35_RS27005	COG3706	GGDEF domain
I6K35_RS27035	COG3621	Patatin-like phospholipase
I6K35_RS27115	COG3504	Conjugal transfer protein
I6K35_RS27145	COG3039	Transposase
I6K35_RS27200	COG4771	TonB-dependent receptor
I6K35_RS27205	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K35_RS27225	COG3433	isochorismatase activity
I6K35_RS27225	COG2226	methyltransferase
I6K35_RS27225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K35_RS27240	COG1132	(ABC) transporter
I6K35_RS27245	COG2814	Major facilitator Superfamily
I6K35_RS27250	COG1169	isochorismate synthase
I6K35_RS27255	COG0582	viral genome integration into host DNA
I6K35_RS27265	COG0534	Mate efflux family protein
I6K35_RS27275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K35_RS27295	COG0604	alcohol dehydrogenase
I6K35_RS27300	COG1309	transcriptional regulator
I6K35_RS27305	COG0025	NhaP-type Na H and K H
I6K35_RS27335	COG0251	oxidation-reduction process
I6K35_RS27425	COG1396	sequence-specific DNA binding
I6K35_RS27445	COG1846	Transcriptional regulator
I6K35_RS27455	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K35_RS27460	COG1403	HNH endonuclease
I6K35_RS27485	COG3179	chitinase
I6K35_RS27540	COG0740	serine-type endopeptidase activity
I6K35_RS27580	COG1196	nuclear chromosome segregation
I6K35_RS27665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K35_RS27675	COG1418	mRNA catabolic process
I6K35_RS27680	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K35_RS27685	COG3727	T/G mismatch-specific endonuclease activity
I6K35_RS27690	COG0697	spore germination
I6K35_RS27695	COG2354	Protein conserved in bacteria
I6K35_RS27725	COG0366	Alpha amylase catalytic
I6K35_RS27730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K35_RS27740	COG0765	amino acid transport
I6K35_RS27805	COG3039	Transposase
I6K35_RS27825	COG3344	reverse transcriptase
I6K35_RS27840	COG3436	PFAM IS66 Orf2 family protein
I6K35_RS27845	COG4372	Transposase
I6K35_RS27940	COG3039	Transposase
I6K35_RS28040	COG3039	Transposase
I6K35_RS28050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K35_RS28080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K35_RS28085	COG3118	belongs to the thioredoxin family
I6K35_RS28090	COG1902	pentaerythritol trinitrate reductase activity
I6K35_RS28095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K35_RS28100	COG1028	Short-chain dehydrogenase reductase Sdr
I6K35_RS28175	COG1842	Phage shock protein A
I6K35_RS28180	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS28240	COG1842	Phage shock protein A
I6K35_RS28245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K35_RS28335	COG1192	Involved in chromosome partitioning
I6K35_RS28350	COG3344	reverse transcriptase