locus-tag	class	description
I6K37_RS00005	COG0439	Biotin carboxylase
I6K37_RS00010	COG0511	ligase activity, forming carbon-carbon bonds
I6K37_RS00035	COG2199	diguanylate cyclase activity
I6K37_RS00035	COG2200	EAL domain
I6K37_RS00040	COG1077	Cell shape determining protein MreB Mrl
I6K37_RS00045	COG1792	Involved in formation and maintenance of cell shape
I6K37_RS00050	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K37_RS00060	COG1530	ribonuclease E activity
I6K37_RS00065	COG3164	Protein of unknown function
I6K37_RS00070	COG0312	modulator of DNA gyrase
I6K37_RS00075	COG0583	DNA-binding transcription factor activity
I6K37_RS00090	COG1289	transmembrane transporter activity
I6K37_RS00095	COG2732	(Barnase) inhibitor
I6K37_RS00130	COG0471	metal ion transport
I6K37_RS00135	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K37_RS00140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K37_RS00165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K37_RS00170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K37_RS00175	COG3105	Protein conserved in bacteria
I6K37_RS00180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K37_RS00200	COG0625	glutathione transferase activity
I6K37_RS00205	COG2969	positive regulation of protein catabolic process
I6K37_RS00215	COG0493	'glutamate synthase
I6K37_RS00220	COG0070	glutamate synthase
I6K37_RS00220	COG0069	glutamate synthase activity
I6K37_RS00220	COG0067	glutamate synthase
I6K37_RS00225	COG1242	4 iron, 4 sulfur cluster binding
I6K37_RS00230	COG2271	Major facilitator Superfamily
I6K37_RS00235	COG1063	alcohol dehydrogenase
I6K37_RS00240	COG1312	Catalyzes the dehydration of D-mannonate
I6K37_RS00245	COG5002	protein histidine kinase activity
I6K37_RS00245	COG2198	Histidine kinase
I6K37_RS00245	COG0784	Response regulator, receiver
I6K37_RS00250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K37_RS00255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K37_RS00260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS00270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS00275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K37_RS00280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K37_RS00285	COG1137	ATPase activity
I6K37_RS00290	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K37_RS00295	COG3117	lipopolysaccharide transmembrane transporter activity
I6K37_RS00300	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K37_RS00310	COG0530	calcium, potassium:sodium antiporter activity
I6K37_RS00315	COG1127	ABC transporter
I6K37_RS00320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K37_RS00325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K37_RS00330	COG2854	intermembrane phospholipid transfer
I6K37_RS00335	COG3113	response to antibiotic
I6K37_RS00340	COG5007	Belongs to the BolA IbaG family
I6K37_RS00350	COG3423	Transcriptional regulator
I6K37_RS00355	COG0142	geranyltranstransferase activity
I6K37_RS00370	COG0697	spore germination
I6K37_RS00380	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K37_RS00390	COG1534	Rna-binding protein
I6K37_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K37_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K37_RS00415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K37_RS00455	COG0195	Participates in both transcription termination and antitermination
I6K37_RS00500	COG0814	amino acid
I6K37_RS00505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K37_RS00510	COG0826	peptidase U32
I6K37_RS00515	COG0826	peptidase U32
I6K37_RS00520	COG3154	lipid carrier protein
I6K37_RS00525	COG3153	acetyltransferase
I6K37_RS00540	COG0693	protein deglycase activity
I6K37_RS00545	COG0702	epimerase
I6K37_RS00550	COG0701	Predicted permease
I6K37_RS00555	COG2823	Periplasmic or secreted lipoprotein
I6K37_RS00575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K37_RS00580	COG2721	sulfolactate sulfo-lyase activity
I6K37_RS00585	COG2271	Major facilitator Superfamily
I6K37_RS00595	COG2084	Dehydrogenase
I6K37_RS00600	COG1929	Belongs to the glycerate kinase type-1 family
I6K37_RS00625	COG1741	Belongs to the pirin family
I6K37_RS00630	COG0583	DNA-binding transcription factor activity
I6K37_RS00635	COG3152	Membrane
I6K37_RS00640	COG0435	Glutathione S-transferase
I6K37_RS00645	COG2259	Doxx family
I6K37_RS00655	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K37_RS00660	COG4575	ribosome binding
I6K37_RS00665	COG1422	Protein of unknown function (DUF1090)
I6K37_RS00675	COG0586	Pfam SNARE associated Golgi protein
I6K37_RS00680	COG2186	Transcriptional regulator
I6K37_RS00685	COG2271	Major facilitator Superfamily
I6K37_RS00695	COG2721	sulfolactate sulfo-lyase activity
I6K37_RS00710	COG0861	Integral membrane protein TerC family
I6K37_RS00715	COG0673	inositol 2-dehydrogenase activity
I6K37_RS00720	COG1451	nucleotide metabolic process
I6K37_RS00740	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K37_RS00740	COG1902	pentaerythritol trinitrate reductase activity
I6K37_RS00790	COG1695	Transcriptional regulator
I6K37_RS00795	COG2375	cellular response to nickel ion
I6K37_RS00810	COG1461	Dihydroxyacetone kinase
I6K37_RS00815	COG2376	Dihydroxyacetone kinase
I6K37_RS00885	COG3247	response to pH
I6K37_RS00895	COG2198	Histidine kinase
I6K37_RS00895	COG0784	Response regulator, receiver
I6K37_RS00895	COG2205	protein histidine kinase activity
I6K37_RS00895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS00900	COG2197	response regulator
I6K37_RS00915	COG0582	viral genome integration into host DNA
I6K37_RS00950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K37_RS00990	COG4695	Portal protein
I6K37_RS01150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K37_RS01155	COG0358	DNA primase activity
I6K37_RS01160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K37_RS01225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K37_RS01240	COG4991	sh3 domain protein
I6K37_RS01245	COG3025	triphosphatase activity
I6K37_RS01270	COG2960	long-chain fatty acid transporting porin activity
I6K37_RS01285	COG3384	dioxygenase
I6K37_RS01290	COG0754	glutathionylspermidine amidase activity
I6K37_RS01305	COG0494	nUDIX hydrolase
I6K37_RS01310	COG3151	Protein conserved in bacteria
I6K37_RS01315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K37_RS01320	COG3150	esterase
I6K37_RS01330	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K37_RS01335	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K37_RS01340	COG0642	Histidine kinase
I6K37_RS01350	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K37_RS01355	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K37_RS01360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K37_RS01365	COG0204	Acyl-transferase
I6K37_RS01370	COG2132	Multicopper oxidase
I6K37_RS01375	COG1032	radical SAM domain protein
I6K37_RS01385	COG0656	L-ascorbic acid biosynthetic process
I6K37_RS01390	COG1979	alcohol dehydrogenase
I6K37_RS01395	COG2207	Transcriptional regulator
I6K37_RS01400	COG0586	Pfam SNARE associated Golgi protein
I6K37_RS01405	COG0626	cystathionine gamma-synthase activity
I6K37_RS01415	COG0848	biopolymer transport protein
I6K37_RS01420	COG2211	Major facilitator Superfamily
I6K37_RS01445	COG0625	glutathione transferase activity
I6K37_RS01460	COG0754	glutathionylspermidine amidase activity
I6K37_RS01465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K37_RS01485	COG0583	DNA-binding transcription factor activity
I6K37_RS01490	COG0626	cystathionine gamma-synthase activity
I6K37_RS01505	COG3121	Chaperone
I6K37_RS01520	COG3121	Chaperone
I6K37_RS01525	COG3121	Chaperone
I6K37_RS01530	COG3188	usher protein
I6K37_RS01555	COG1811	Na channel or pump
I6K37_RS01560	COG1982	Orn Lys Arg decarboxylase major
I6K37_RS01565	COG2211	Major facilitator Superfamily
I6K37_RS01580	COG1194	a g-specific adenine glycosylase
I6K37_RS01590	COG3171	Protein conserved in bacteria
I6K37_RS01600	COG4214	carbohydrate transport
I6K37_RS01615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K37_RS01630	COG0762	integral membrane protein
I6K37_RS01635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K37_RS01640	COG2805	Type II/IV secretion system protein
I6K37_RS01660	COG0189	ligase activity
I6K37_RS01665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K37_RS01670	COG2356	endonuclease I
I6K37_RS01680	COG2814	Major facilitator Superfamily
I6K37_RS01715	COG0501	Belongs to the peptidase M48B family
I6K37_RS01720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K37_RS01735	COG0191	fructose-bisphosphate aldolase activity
I6K37_RS01740	COG0668	transmembrane transport
I6K37_RS01750	COG2968	Membrane
I6K37_RS01765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K37_RS01770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K37_RS01790	COG0006	proline dipeptidase activity
I6K37_RS01795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K37_RS01800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K37_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS01825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K37_RS01845	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS01850	COG1737	Transcriptional regulator
I6K37_RS01860	COG1272	protein, Hemolysin III
I6K37_RS01870	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K37_RS01880	COG0716	FMN binding
I6K37_RS01885	COG4974	Belongs to the 'phage' integrase family
I6K37_RS01895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K37_RS01915	COG1811	Na channel or pump
I6K37_RS01925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K37_RS01930	COG0583	DNA-binding transcription factor activity
I6K37_RS01935	COG4942	peptidase
I6K37_RS01945	COG2814	Major facilitator Superfamily
I6K37_RS01960	COG0667	Aldo Keto reductase
I6K37_RS02000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K37_RS02005	COG1393	Belongs to the ArsC family
I6K37_RS02020	COG1538	Outer membrane efflux protein
I6K37_RS02025	COG1289	transmembrane transporter activity
I6K37_RS02040	COG3592	Divergent 4Fe-4S mono-cluster
I6K37_RS02045	COG2388	GCN5-related N-acetyl-transferase
I6K37_RS02055	COG3539	Fimbrial protein
I6K37_RS02060	COG3539	Fimbrial protein
I6K37_RS02065	COG3539	Fimbrial protein
I6K37_RS02070	COG3188	usher protein
I6K37_RS02075	COG3121	Chaperone
I6K37_RS02080	COG3539	Fimbrial protein
I6K37_RS02090	COG4974	Belongs to the 'phage' integrase family
I6K37_RS02095	COG0582	viral genome integration into host DNA
I6K37_RS02100	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K37_RS02105	COG1846	Transcriptional regulator
I6K37_RS02110	COG0697	spore germination
I6K37_RS02160	COG0667	Aldo Keto reductase
I6K37_RS02165	COG0814	amino acid
I6K37_RS02180	COG0183	Belongs to the thiolase family
I6K37_RS02190	COG0823	Involved in the tonB-independent uptake of proteins
I6K37_RS02195	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS02200	COG2814	Major facilitator Superfamily
I6K37_RS02235	COG3842	ATPase activity
I6K37_RS02240	COG0395	ABC-type sugar transport system, permease component
I6K37_RS02245	COG1175	transmembrane transport
I6K37_RS02250	COG1917	Cupin 2, conserved barrel domain protein
I6K37_RS02255	COG1794	racemase activity, acting on amino acids and derivatives
I6K37_RS02260	COG0583	DNA-binding transcription factor activity
I6K37_RS02270	COG1609	Transcriptional regulator
I6K37_RS02275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS02280	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS02285	COG2186	Transcriptional regulator
I6K37_RS02295	COG1609	Transcriptional regulator
I6K37_RS02315	COG0667	Aldo Keto reductase
I6K37_RS02325	COG0861	Integral membrane protein TerC family
I6K37_RS02360	COG2165	general secretion pathway protein
I6K37_RS02365	COG4795	General secretion pathway protein
I6K37_RS02375	COG4967	type IV pilus modification protein PilV
I6K37_RS02380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K37_RS02385	COG1025	Belongs to the peptidase M16 family
I6K37_RS02390	COG1074	ATP-dependent DNA helicase activity
I6K37_RS02395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K37_RS02405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K37_RS02405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K37_RS02410	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K37_RS02415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K37_RS02445	COG4656	Part of a membrane complex involved in electron transport
I6K37_RS02450	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS02450	COG1454	alcohol dehydrogenase
I6K37_RS02480	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K37_RS02685	COG2885	chlorophyll binding
I6K37_RS02720	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K37_RS02725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K37_RS02730	COG2166	iron-sulfur cluster assembly
I6K37_RS02735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K37_RS02745	COG0583	DNA-binding transcription factor activity
I6K37_RS02750	COG2363	Small membrane protein
I6K37_RS02760	COG1349	DNA-binding transcription factor activity
I6K37_RS02780	COG0738	Major facilitator superfamily
I6K37_RS02785	COG0235	Class ii aldolase
I6K37_RS02790	COG1454	alcohol dehydrogenase
I6K37_RS02810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K37_RS02825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K37_RS02830	COG2011	ABC-type metal ion transport system permease component
I6K37_RS02835	COG1464	Belongs to the NlpA lipoprotein family
I6K37_RS02840	COG0477	Major facilitator Superfamily
I6K37_RS02850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K37_RS02855	COG1760	l-serine dehydratase
I6K37_RS02860	COG0814	amino acid
I6K37_RS02865	COG1611	Belongs to the LOG family
I6K37_RS02880	COG3098	single-species biofilm formation
I6K37_RS02885	COG0564	pseudouridine synthase activity
I6K37_RS02890	COG0716	FMN binding
I6K37_RS02895	COG2271	Major facilitator Superfamily
I6K37_RS02900	COG4948	Mandelate Racemase Muconate Lactonizing
I6K37_RS02905	COG4948	Mandelate Racemase Muconate Lactonizing
I6K37_RS02910	COG1929	Belongs to the glycerate kinase type-1 family
I6K37_RS02925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K37_RS02930	COG3956	TIGRFAM MazG family protein
I6K37_RS02950	COG0602	queuosine metabolic process
I6K37_RS02955	COG0720	synthase
I6K37_RS02975	COG2234	aminopeptidase activity
I6K37_RS03035	COG4942	peptidase
I6K37_RS03035	COG1388	LysM domain
I6K37_RS03040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K37_RS03065	COG0163	prenyltransferase activity
I6K37_RS03070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K37_RS03110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS03115	COG4558	Periplasmic binding protein
I6K37_RS03120	COG3720	iron ion transport
I6K37_RS03140	COG0679	Auxin Efflux Carrier
I6K37_RS03155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K37_RS03160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K37_RS03165	COG1121	(ABC) transporter
I6K37_RS03170	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K37_RS03175	COG1609	Transcriptional regulator
I6K37_RS03180	COG1940	carbohydrate kinase activity
I6K37_RS03185	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K37_RS03190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS03195	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS03200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS03205	COG4580	involved in the transport of maltose and maltodextrins
I6K37_RS03215	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS03225	COG0309	Hydrogenase expression formation protein (HypE)
I6K37_RS03230	COG0409	Hydrogenase expression formation protein
I6K37_RS03235	COG0298	carbon dioxide binding
I6K37_RS03240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K37_RS03255	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K37_RS03260	COG0651	ATP synthesis coupled electron transport
I6K37_RS03265	COG0650	Formate hydrogenlyase subunit 4
I6K37_RS03270	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K37_RS03270	COG3261	NADH dehydrogenase
I6K37_RS03275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K37_RS03280	COG3260	NADH ubiquinone oxidoreductase 20
I6K37_RS03290	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K37_RS03300	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS03305	COG1263	PTS System
I6K37_RS03305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K37_RS03310	COG1609	Transcriptional regulator
I6K37_RS03315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K37_RS03320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K37_RS03325	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K37_RS03350	COG1349	DNA-binding transcription factor activity
I6K37_RS03355	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS03370	COG3732	PTS system glucitol sorbitol-specific
I6K37_RS03375	COG3730	PTS system glucitol sorbitol-specific
I6K37_RS03380	COG2951	lytic endotransglycosylase activity
I6K37_RS03385	COG1121	(ABC) transporter
I6K37_RS03390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K37_RS03395	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K37_RS03400	COG1546	Belongs to the CinA family
I6K37_RS03420	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K37_RS03450	COG2823	Periplasmic or secreted lipoprotein
I6K37_RS03455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K37_RS03460	COG1238	metal cluster binding
I6K37_RS03480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K37_RS03485	COG2814	Major facilitator Superfamily
I6K37_RS03490	COG1566	PFAM secretion protein HlyD family protein
I6K37_RS03495	COG1846	Transcriptional regulator
I6K37_RS03505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K37_RS03515	COG4176	ABC-type proline glycine betaine transport system permease component
I6K37_RS03530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K37_RS03540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K37_RS03545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K37_RS03550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K37_RS03555	COG4575	ribosome binding
I6K37_RS03570	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K37_RS03585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K37_RS03590	COG0640	Transcriptional regulator
I6K37_RS03600	COG0583	DNA-binding transcription factor activity
I6K37_RS03605	COG3284	Transcriptional regulator
I6K37_RS03615	COG3539	Fimbrial protein
I6K37_RS03620	COG3121	Chaperone
I6K37_RS03640	COG3188	usher protein
I6K37_RS03650	COG3539	Fimbrial protein
I6K37_RS03655	COG2197	response regulator
I6K37_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS03680	COG0235	Class ii aldolase
I6K37_RS03690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS03730	COG3708	Transcriptional regulator
I6K37_RS03730	COG2207	Transcriptional regulator
I6K37_RS03835	COG4974	Belongs to the 'phage' integrase family
I6K37_RS03840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6K37_RS03920	COG3429	Glucose-6-phosphate dehydrogenase subunit
I6K37_RS03920	COG3409	Peptidoglycan-binding domain 1 protein
I6K37_RS03935	COG0582	viral genome integration into host DNA
I6K37_RS03950	COG2867	negative regulation of translational initiation
I6K37_RS03965	COG0497	DNA recombination
I6K37_RS03980	COG4536	flavin adenine dinucleotide binding
I6K37_RS03985	COG4137	Cytochrome C assembly protein
I6K37_RS03990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K37_RS04025	COG2885	chlorophyll binding
I6K37_RS04030	COG2199	diguanylate cyclase activity
I6K37_RS04040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K37_RS04045	COG0287	Prephenate dehydrogenase
I6K37_RS04045	COG1605	Chorismate mutase
I6K37_RS04055	COG0077	Prephenate dehydratase
I6K37_RS04055	COG1605	Chorismate mutase
I6K37_RS04065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K37_RS04070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K37_RS04085	COG0542	response to heat
I6K37_RS04110	COG0477	Major facilitator Superfamily
I6K37_RS04115	COG5544	Lipoprotein
I6K37_RS04120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K37_RS04130	COG3148	PFAM DTW domain containing protein
I6K37_RS04135	COG3118	belongs to the thioredoxin family
I6K37_RS04140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K37_RS04155	COG0513	Belongs to the DEAD box helicase family
I6K37_RS04165	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K37_RS04180	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K37_RS04185	COG3026	antisigma factor binding
I6K37_RS04190	COG3086	response to oxidative stress
I6K37_RS04200	COG0681	Belongs to the peptidase S26 family
I6K37_RS04220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K37_RS04230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K37_RS04235	COG1737	Transcriptional regulator
I6K37_RS04240	COG0560	Phosphoserine phosphatase
I6K37_RS04255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K37_RS04255	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K37_RS04260	COG2205	protein histidine kinase activity
I6K37_RS04265	COG3170	Tfp pilus assembly protein FimV
I6K37_RS04270	COG2204	response regulator
I6K37_RS04275	COG0347	Belongs to the P(II) protein family
I6K37_RS04280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K37_RS04280	COG1017	nitric oxide dioxygenase activity
I6K37_RS04290	COG2259	Doxx family
I6K37_RS04295	COG1940	carbohydrate kinase activity
I6K37_RS04300	COG0457	Tetratricopeptide repeat
I6K37_RS04305	COG0477	Major facilitator Superfamily
I6K37_RS04305	COG2814	Major facilitator Superfamily
I6K37_RS04310	COG2017	converts alpha-aldose to the beta-anomer
I6K37_RS04315	COG2814	Major facilitator Superfamily
I6K37_RS04320	COG3711	transcriptional antiterminator
I6K37_RS04325	COG3683	transport system, periplasmic component
I6K37_RS04330	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K37_RS04360	COG0822	iron-sulfur transferase activity
I6K37_RS04380	COG0633	Ferredoxin
I6K37_RS04385	COG2975	iron-sulfur cluster assembly
I6K37_RS04405	COG2897	thiosulfate sulfurtransferase activity
I6K37_RS04410	COG2373	Large extracellular alpha-helical protein
I6K37_RS04415	COG4953	penicillin-binding protein 1C
I6K37_RS04445	COG2976	Protein conserved in bacteria
I6K37_RS04465	COG1645	bacterial-type flagellum-dependent swarming motility
I6K37_RS04475	COG0517	IMP dehydrogenase activity
I6K37_RS04475	COG0516	GMP reductase activity
I6K37_RS04485	COG3119	arylsulfatase activity
I6K37_RS04490	COG0641	radical SAM
I6K37_RS04510	COG2200	EAL domain
I6K37_RS04525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K37_RS04540	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS04550	COG2233	PERMEase
I6K37_RS04565	COG1393	Belongs to the ArsC family
I6K37_RS04570	COG4783	chaperone-mediated protein folding
I6K37_RS04580	COG0628	permease
I6K37_RS04585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K37_RS04590	COG2716	regulation of RNA biosynthetic process
I6K37_RS04600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K37_RS04610	COG2321	neutral zinc metallopeptidase
I6K37_RS04615	COG1444	tRNA N-acetyltransferase activity
I6K37_RS04620	COG0400	carboxylic ester hydrolase activity
I6K37_RS04635	COG1393	Belongs to the ArsC family
I6K37_RS04645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K37_RS04650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K37_RS04650	COG0493	'glutamate synthase
I6K37_RS04660	COG5342	invasion associated locus B
I6K37_RS04665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K37_RS04670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K37_RS04680	COG4810	utilization protein
I6K37_RS04770	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K37_RS04790	COG2837	iron assimilation
I6K37_RS04800	COG4150	thiosulfate binding
I6K37_RS04805	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K37_RS04810	COG4208	sulfate ABC transporter
I6K37_RS04815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K37_RS04825	COG4319	ketosteroid isomerase
I6K37_RS04860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K37_RS04880	COG3530	Putative quorum-sensing-regulated virulence factor
I6K37_RS04885	COG0385	Bile acid
I6K37_RS04890	COG0583	DNA-binding transcription factor activity
I6K37_RS04920	COG3415	Transposase
I6K37_RS04925	COG3415	Transposase
I6K37_RS04940	COG2200	EAL domain
I6K37_RS04940	COG2199	diguanylate cyclase activity
I6K37_RS04945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K37_RS04960	COG0667	Aldo Keto reductase
I6K37_RS04965	COG3961	Belongs to the TPP enzyme family
I6K37_RS04980	COG3279	Response regulator of the LytR AlgR family
I6K37_RS04985	COG3275	phosphorelay sensor kinase activity
I6K37_RS05000	COG0436	Aminotransferase
I6K37_RS05010	COG2807	transmembrane transport
I6K37_RS05015	COG0590	tRNA wobble adenosine to inosine editing
I6K37_RS05020	COG0583	DNA-binding transcription factor activity
I6K37_RS05040	COG0582	viral genome integration into host DNA
I6K37_RS05110	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K37_RS05115	COG1403	HNH endonuclease
I6K37_RS05315	COG2116	formate transmembrane transporter activity
I6K37_RS05320	COG2853	Lipoprotein
I6K37_RS05330	COG3691	Protein conserved in bacteria
I6K37_RS05345	COG2062	phosphohistidine phosphatase, SixA
I6K37_RS05370	COG0730	response to heat
I6K37_RS05375	COG3101	peptidyl-lysine hydroxylation
I6K37_RS05390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K37_RS05410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K37_RS05420	COG0586	Pfam SNARE associated Golgi protein
I6K37_RS05430	COG0285	dihydrofolate synthase activity
I6K37_RS05435	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K37_RS05440	COG1286	toxin biosynthetic process
I6K37_RS05445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K37_RS05450	COG0163	prenyltransferase activity
I6K37_RS05475	COG4160	amino acid transport
I6K37_RS05480	COG4598	ABC transporter
I6K37_RS05495	COG1090	epimerase
I6K37_RS05500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K37_RS05505	COG0625	glutathione transferase activity
I6K37_RS05510	COG0625	glutathione transferase activity
I6K37_RS05515	COG0622	Phosphoesterase
I6K37_RS05520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K37_RS05525	COG0857	belongs to the CobB CobQ family
I6K37_RS05525	COG0280	phosphate acetyltransferase
I6K37_RS05545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K37_RS05550	COG0471	metal ion transport
I6K37_RS05550	COG0490	domain, Protein
I6K37_RS05560	COG0436	Aminotransferase
I6K37_RS05565	COG0583	DNA-binding transcription factor activity
I6K37_RS05610	COG0839	Belongs to the complex I subunit 6 family
I6K37_RS05620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K37_RS05625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K37_RS05640	COG2153	protein acetylation
I6K37_RS05645	COG1169	isochorismate synthase
I6K37_RS05670	COG0318	PFAM AMP-dependent synthetase and ligase
I6K37_RS05680	COG5464	transposase or invertase
I6K37_RS05695	COG1414	Transcriptional regulator
I6K37_RS05705	COG2271	Major facilitator Superfamily
I6K37_RS05715	COG0247	lactate metabolic process
I6K37_RS05725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K37_RS05740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K37_RS05765	COG2205	protein histidine kinase activity
I6K37_RS05765	COG0784	Response regulator, receiver
I6K37_RS05775	COG0642	Histidine kinase
I6K37_RS05775	COG2198	Histidine kinase
I6K37_RS05790	COG2169	Transcriptional regulator
I6K37_RS05790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K37_RS05795	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K37_RS05800	COG4615	Cyclic peptide transporter
I6K37_RS05805	COG2239	Acts as a magnesium transporter
I6K37_RS05810	COG0659	secondary active sulfate transmembrane transporter activity
I6K37_RS05825	COG0628	permease
I6K37_RS05850	COG1349	DNA-binding transcription factor activity
I6K37_RS05855	COG0494	nUDIX hydrolase
I6K37_RS05875	COG1061	Type III restriction enzyme res subunit
I6K37_RS05880	COG1187	pseudouridine synthase activity
I6K37_RS05885	COG2814	Major facilitator Superfamily
I6K37_RS05895	COG4172	Belongs to the ABC transporter superfamily
I6K37_RS05900	COG4239	(ABC) transporter, permease
I6K37_RS05905	COG4174	ABC transporter (Permease)
I6K37_RS05910	COG4166	transmembrane transport
I6K37_RS05915	COG2200	EAL domain
I6K37_RS05920	COG0791	NLP P60 protein
I6K37_RS05925	COG0671	phosphoesterase, PA-phosphatase related
I6K37_RS05930	COG0523	cobalamin synthesis protein
I6K37_RS05935	COG0246	Mannitol dehydrogenase
I6K37_RS05940	COG1312	Catalyzes the dehydration of D-mannonate
I6K37_RS05960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS05960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS05965	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K37_RS05970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS05970	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K37_RS05970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS05980	COG2855	membrane
I6K37_RS05985	COG0583	DNA-binding transcription factor activity
I6K37_RS05990	COG0833	amino acid
I6K37_RS05995	COG4771	TonB-dependent receptor
I6K37_RS06010	COG2311	Membrane
I6K37_RS06025	COG1129	ABC transporter
I6K37_RS06035	COG2949	membrane
I6K37_RS06045	COG1346	cytolysis
I6K37_RS06055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K37_RS06060	COG3659	wide pore channel activity
I6K37_RS06075	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS06085	COG1538	Outer membrane efflux protein
I6K37_RS06090	COG0586	Pfam SNARE associated Golgi protein
I6K37_RS06100	COG1686	Belongs to the peptidase S11 family
I6K37_RS06110	COG0277	FAD linked oxidase domain protein
I6K37_RS06115	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K37_RS06120	COG1732	Glycine betaine
I6K37_RS06125	COG1174	glycine betaine transport
I6K37_RS06130	COG1125	glycine betaine transport
I6K37_RS06135	COG1174	glycine betaine transport
I6K37_RS06145	COG3275	phosphorelay sensor kinase activity
I6K37_RS06155	COG4807	Protein conserved in bacteria
I6K37_RS06175	COG5455	response to cobalt ion
I6K37_RS06180	COG0583	DNA-binding transcription factor activity
I6K37_RS06185	COG2252	PERMEase
I6K37_RS06195	COG0583	DNA-binding transcription factor activity
I6K37_RS06210	COG0351	phosphomethylpyrimidine kinase
I6K37_RS06215	COG1830	Aldolase
I6K37_RS06250	COG1070	Carbohydrate kinase
I6K37_RS06260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K37_RS06265	COG4948	Mandelate Racemase Muconate Lactonizing
I6K37_RS06270	COG0747	negative chemotaxis
I6K37_RS06275	COG0601	transmembrane transport
I6K37_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS06285	COG0444	Belongs to the ABC transporter superfamily
I6K37_RS06290	COG4608	Belongs to the ABC transporter superfamily
I6K37_RS06300	COG0826	peptidase U32
I6K37_RS06305	COG0745	RESPONSE REGULATOR receiver
I6K37_RS06310	COG2205	protein histidine kinase activity
I6K37_RS06335	COG1301	dicarboxylic acid transport
I6K37_RS06355	COG5002	protein histidine kinase activity
I6K37_RS06360	COG0443	Heat shock 70 kDa protein
I6K37_RS06365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K37_RS06380	COG2982	Protein involved in outer membrane biogenesis
I6K37_RS06385	COG1253	flavin adenine dinucleotide binding
I6K37_RS06520	COG0438	transferase activity, transferring glycosyl groups
I6K37_RS06525	COG1215	transferase activity, transferring glycosyl groups
I6K37_RS06545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K37_RS06575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K37_RS06580	COG0583	DNA-binding transcription factor activity
I6K37_RS06590	COG0531	amino acid
I6K37_RS06595	COG0640	Transcriptional regulator
I6K37_RS06600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K37_RS06605	COG2925	Exonuclease
I6K37_RS06620	COG1289	transmembrane transporter activity
I6K37_RS06640	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K37_RS06650	COG1942	4-Oxalocrotonate Tautomerase
I6K37_RS06655	COG0583	DNA-binding transcription factor activity
I6K37_RS06660	COG0095	Lipoate-protein ligase
I6K37_RS06665	COG0477	Major facilitator Superfamily
I6K37_RS06675	COG3300	MHYT domain
I6K37_RS06675	COG5001	Diguanylate cyclase
I6K37_RS06680	COG3615	Tellurite resistance protein tehB
I6K37_RS06705	COG3706	GGDEF domain
I6K37_RS06720	COG0534	Mate efflux family protein
I6K37_RS06730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K37_RS06750	COG0604	alcohol dehydrogenase
I6K37_RS06755	COG1309	transcriptional regulator
I6K37_RS06760	COG0025	NhaP-type Na H and K H
I6K37_RS06810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K37_RS06820	COG1418	mRNA catabolic process
I6K37_RS06825	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K37_RS06830	COG3727	T/G mismatch-specific endonuclease activity
I6K37_RS06835	COG0697	spore germination
I6K37_RS06840	COG2354	Protein conserved in bacteria
I6K37_RS06870	COG0366	Alpha amylase catalytic
I6K37_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS06885	COG0765	amino acid transport
I6K37_RS06890	COG1126	abc transporter atp-binding protein
I6K37_RS06895	COG2197	response regulator
I6K37_RS06905	COG2197	response regulator
I6K37_RS06940	COG3012	SEC-C Motif Domain Protein
I6K37_RS06940	COG3318	Belongs to the UPF0149 family
I6K37_RS06945	COG0814	amino acid
I6K37_RS06955	COG1528	Iron-storage protein
I6K37_RS06970	COG0477	Major facilitator Superfamily
I6K37_RS06980	COG2211	Major facilitator Superfamily
I6K37_RS06990	COG1528	Iron-storage protein
I6K37_RS07000	COG1879	ABC-type sugar transport system periplasmic component
I6K37_RS07010	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS07035	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K37_RS07045	COG3102	Protein conserved in bacteria
I6K37_RS07065	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K37_RS07070	COG1801	Protein of unknown function DUF72
I6K37_RS07075	COG1335	isochorismatase
I6K37_RS07085	COG0494	nUDIX hydrolase
I6K37_RS07110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K37_RS07120	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K37_RS07130	COG1560	Kdo2-lipid A biosynthetic process
I6K37_RS07140	COG1737	Transcriptional regulator
I6K37_RS07150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K37_RS07155	COG0129	dihydroxy-acid dehydratase activity
I6K37_RS07160	COG0800	Aldolase
I6K37_RS07170	COG3141	response to X-ray
I6K37_RS07175	COG2979	Protein of unknown function (DUF533)
I6K37_RS07180	COG1770	oligopeptidase
I6K37_RS07185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K37_RS07195	COG2372	response to copper ion
I6K37_RS07200	COG1276	copper resistance
I6K37_RS07215	COG2990	Protein conserved in bacteria
I6K37_RS07240	COG3008	intermembrane lipid transfer
I6K37_RS07245	COG2995	paraquat-inducible protein a
I6K37_RS07250	COG1956	GAF domain-containing protein
I6K37_RS07270	COG2814	Major facilitator Superfamily
I6K37_RS07275	COG1414	Transcriptional regulator
I6K37_RS07305	COG0768	penicillin binding
I6K37_RS07310	COG2226	methyltransferase
I6K37_RS07325	COG3716	PTS system mannose fructose sorbose family IID component
I6K37_RS07330	COG3715	PTS system
I6K37_RS07335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K37_RS07335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS07340	COG1253	flavin adenine dinucleotide binding
I6K37_RS07345	COG2200	EAL domain
I6K37_RS07350	COG1760	l-serine dehydratase
I6K37_RS07370	COG0251	oxidation-reduction process
I6K37_RS07375	COG1199	ATP-dependent helicase activity
I6K37_RS07385	COG3065	identical protein binding
I6K37_RS07395	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K37_RS07405	COG2894	cell division
I6K37_RS07420	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K37_RS07450	COG2719	SpoVR family
I6K37_RS07475	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K37_RS07485	COG4774	siderophore transport
I6K37_RS07500	COG2308	Evidence 4 Homologs of previously reported genes of
I6K37_RS07545	COG0583	DNA-binding transcription factor activity
I6K37_RS07550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K37_RS07565	COG1882	Formate acetyltransferase
I6K37_RS07600	COG0583	DNA-binding transcription factor activity
I6K37_RS07630	COG0583	DNA-binding transcription factor activity
I6K37_RS07645	COG3122	Protein conserved in bacteria
I6K37_RS07695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K37_RS07775	COG0012	GTP binding
I6K37_RS07795	COG0659	secondary active sulfate transmembrane transporter activity
I6K37_RS07825	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K37_RS07845	COG0387	Pfam Sodium calcium exchanger
I6K37_RS07850	COG4572	Cation transport regulator
I6K37_RS07855	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K37_RS07865	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K37_RS07870	COG3707	response regulator
I6K37_RS07875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K37_RS07885	COG1116	anion transmembrane transporter activity
I6K37_RS07890	COG2146	nitrite reductase [NAD(P)H] activity
I6K37_RS07890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K37_RS07895	COG0243	molybdopterin cofactor binding
I6K37_RS07900	COG4932	domain protein
I6K37_RS07905	COG2197	response regulator
I6K37_RS07910	COG3850	Histidine kinase
I6K37_RS07915	COG2223	nitrite transmembrane transporter activity
I6K37_RS07925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K37_RS07930	COG1140	nitrate reductase beta subunit
I6K37_RS07935	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K37_RS07940	COG2181	nitrate reductase activity
I6K37_RS07950	COG1522	sequence-specific DNA binding
I6K37_RS07990	COG0788	formyltetrahydrofolate deformylase activity
I6K37_RS08000	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K37_RS08005	COG0745	RESPONSE REGULATOR receiver
I6K37_RS08010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K37_RS08015	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K37_RS08025	COG1435	thymidine kinase activity
I6K37_RS08030	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS08030	COG1454	alcohol dehydrogenase
I6K37_RS08040	COG2095	MarC family integral membrane protein
I6K37_RS08045	COG4166	transmembrane transport
I6K37_RS08050	COG0601	transmembrane transport
I6K37_RS08055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS08060	COG0444	Belongs to the ABC transporter superfamily
I6K37_RS08070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K37_RS08090	COG2353	YceI-like domain
I6K37_RS08100	COG2350	Protein conserved in bacteria
I6K37_RS08110	COG3001	Fructosamine kinase
I6K37_RS08120	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K37_RS08125	COG3137	Salt-induced outer membrane protein
I6K37_RS08165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K37_RS08165	COG0072	phenylalanine-tRNA ligase activity
I6K37_RS08185	COG0583	DNA-binding transcription factor activity
I6K37_RS08205	COG0386	Belongs to the glutathione peroxidase family
I6K37_RS08215	COG0791	NLP P60 protein
I6K37_RS08225	COG4256	Hemin uptake protein
I6K37_RS08230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K37_RS08245	COG0574	Belongs to the PEP-utilizing enzyme family
I6K37_RS08245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K37_RS08255	COG0628	permease
I6K37_RS08260	COG0247	lactate metabolic process
I6K37_RS08260	COG0277	FAD linked oxidase domain protein
I6K37_RS08265	COG2050	protein possibly involved in aromatic compounds catabolism
I6K37_RS08270	COG2261	transglycosylase associated protein
I6K37_RS08295	COG1120	ATPase activity
I6K37_RS08300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS08310	COG0583	DNA-binding transcription factor activity
I6K37_RS08335	COG1304	FMN binding
I6K37_RS08340	COG1309	transcriptional regulator
I6K37_RS08360	COG0316	Belongs to the HesB IscA family
I6K37_RS08365	COG0719	Fe-S assembly protein
I6K37_RS08370	COG0396	ATPase activity
I6K37_RS08375	COG0719	Fe-S assembly protein
I6K37_RS08390	COG1376	ErfK ybiS ycfS ynhG family protein
I6K37_RS08420	COG1309	transcriptional regulator
I6K37_RS08425	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K37_RS08425	COG1082	Xylose isomerase domain protein TIM barrel
I6K37_RS08430	COG2271	Major facilitator Superfamily
I6K37_RS08435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K37_RS08445	COG1120	ATPase activity
I6K37_RS08450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS08455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K37_RS08460	COG1414	Transcriptional regulator
I6K37_RS08495	COG2814	Major facilitator Superfamily
I6K37_RS08515	COG0583	DNA-binding transcription factor activity
I6K37_RS08520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K37_RS08540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K37_RS08545	COG1116	anion transmembrane transporter activity
I6K37_RS08550	COG4774	siderophore transport
I6K37_RS08555	COG1120	ATPase activity
I6K37_RS08560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS08565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS08585	COG0765	amino acid transport
I6K37_RS08590	COG1126	abc transporter atp-binding protein
I6K37_RS08630	COG3383	formate dehydrogenase (NAD+) activity
I6K37_RS08635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K37_RS08645	COG1175	transmembrane transport
I6K37_RS08675	COG1857	crispr-associated protein
I6K37_RS08685	COG1518	maintenance of DNA repeat elements
I6K37_RS08690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K37_RS08695	COG3157	Type VI secretion system effector, Hcp
I6K37_RS08725	COG4133	protoheme IX ABC transporter activity
I6K37_RS08730	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K37_RS08735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K37_RS08750	COG1138	Cytochrome C-type biogenesis protein
I6K37_RS08755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K37_RS08760	COG3088	subunit of a heme lyase
I6K37_RS08760	COG4235	cytochrome complex assembly
I6K37_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS08805	COG2610	gluconate transmembrane transporter activity
I6K37_RS08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K37_RS08820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K37_RS08830	COG0583	DNA-binding transcription factor activity
I6K37_RS08850	COG0277	FAD linked oxidase domain protein
I6K37_RS08855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K37_RS08880	COG0402	S-adenosylhomocysteine deaminase activity
I6K37_RS08920	COG2200	EAL domain
I6K37_RS08935	COG2205	protein histidine kinase activity
I6K37_RS08940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS08960	COG2200	EAL domain
I6K37_RS09000	COG2814	Major facilitator Superfamily
I6K37_RS09005	COG1082	Xylose isomerase domain protein TIM barrel
I6K37_RS09015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K37_RS09045	COG4608	Belongs to the ABC transporter superfamily
I6K37_RS09050	COG0444	Belongs to the ABC transporter superfamily
I6K37_RS09075	COG0346	lactoylglutathione lyase activity
I6K37_RS09080	COG1349	DNA-binding transcription factor activity
I6K37_RS09115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K37_RS09135	COG0300	oxidoreductase activity
I6K37_RS09175	COG0307	riboflavin synthase, alpha
I6K37_RS09180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K37_RS09185	COG2814	Major facilitator Superfamily
I6K37_RS09190	COG0583	DNA-binding transcription factor activity
I6K37_RS09205	COG2814	Major facilitator Superfamily
I6K37_RS09220	COG0791	NLP P60 protein
I6K37_RS09225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K37_RS09235	COG0346	lactoylglutathione lyase activity
I6K37_RS09240	COG1902	pentaerythritol trinitrate reductase activity
I6K37_RS09245	COG1309	transcriptional regulator
I6K37_RS09250	COG3313	Fe-S protein
I6K37_RS09255	COG4989	oxidoreductase activity
I6K37_RS09260	COG2032	superoxide dismutase activity
I6K37_RS09265	COG1289	transmembrane transporter activity
I6K37_RS09270	COG1566	PFAM secretion protein HlyD family protein
I6K37_RS09285	COG3706	GGDEF domain
I6K37_RS09300	COG3895	Periplasmic Protein
I6K37_RS09315	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K37_RS09320	COG0625	glutathione transferase activity
I6K37_RS09330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K37_RS09340	COG4659	FMN binding
I6K37_RS09375	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS09385	COG0673	inositol 2-dehydrogenase activity
I6K37_RS09395	COG2814	Major facilitator Superfamily
I6K37_RS09415	COG3038	cytochrome b561
I6K37_RS09435	COG0583	DNA-binding transcription factor activity
I6K37_RS09440	COG3485	protocatechuate 3,4-dioxygenase
I6K37_RS09445	COG3485	protocatechuate 3,4-dioxygenase
I6K37_RS09450	COG5383	Protein conserved in bacteria
I6K37_RS09455	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K37_RS09470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K37_RS09475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K37_RS09480	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K37_RS09485	COG0500	methyltransferase
I6K37_RS09495	COG0697	spore germination
I6K37_RS09500	COG3708	Transcriptional regulator
I6K37_RS09500	COG2207	Transcriptional regulator
I6K37_RS09505	COG3135	benzoate transporter
I6K37_RS09510	COG1396	sequence-specific DNA binding
I6K37_RS09520	COG0826	peptidase U32
I6K37_RS09540	COG1294	oxidase, subunit
I6K37_RS09545	COG1271	oxidase subunit
I6K37_RS09550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K37_RS09555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K37_RS09560	COG3842	ATPase activity
I6K37_RS09565	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K37_RS09570	COG1177	transmembrane transport
I6K37_RS09575	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS09610	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS09615	COG0747	negative chemotaxis
I6K37_RS09625	COG3238	Protein conserved in bacteria
I6K37_RS09630	COG1247	-acetyltransferase
I6K37_RS09640	COG2130	NADP-dependent
I6K37_RS09655	COG3691	Protein conserved in bacteria
I6K37_RS09660	COG1228	amidohydrolase
I6K37_RS09665	COG4772	TonB-dependent receptor
I6K37_RS09690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K37_RS09695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K37_RS09700	COG1473	amidohydrolase
I6K37_RS09705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K37_RS09710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS09720	COG0765	amino acid transport
I6K37_RS09725	COG1126	abc transporter atp-binding protein
I6K37_RS09735	COG0625	glutathione transferase activity
I6K37_RS09755	COG2211	Major facilitator Superfamily
I6K37_RS09770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K37_RS09775	COG3842	ATPase activity
I6K37_RS09780	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K37_RS09785	COG1178	ABC-type Fe3 transport system permease component
I6K37_RS09790	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K37_RS09795	COG2181	nitrate reductase activity
I6K37_RS09800	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K37_RS09805	COG1140	nitrate reductase beta subunit
I6K37_RS09810	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K37_RS09830	COG1414	Transcriptional regulator
I6K37_RS09835	COG4948	Mandelate Racemase Muconate Lactonizing
I6K37_RS09840	COG4829	muconolactone delta-isomerase
I6K37_RS09845	COG3485	protocatechuate 3,4-dioxygenase
I6K37_RS09855	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K37_RS09880	COG0437	4 iron, 4 sulfur cluster binding
I6K37_RS09885	COG2864	formate dehydrogenase
I6K37_RS09900	COG2326	polyphosphate kinase activity
I6K37_RS09910	COG2814	Major facilitator Superfamily
I6K37_RS09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K37_RS09930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS09940	COG0747	negative chemotaxis
I6K37_RS09945	COG1064	alcohol dehydrogenase
I6K37_RS09960	COG0488	(ABC) transporter
I6K37_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS10005	COG3729	General stress protein
I6K37_RS10015	COG3685	Protein conserved in bacteria
I6K37_RS10025	COG0366	Alpha amylase catalytic
I6K37_RS10035	COG2323	membrane
I6K37_RS10045	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K37_RS10055	COG1764	response to oxidative stress
I6K37_RS10080	COG3781	membrane
I6K37_RS10085	COG0243	molybdopterin cofactor binding
I6K37_RS10090	COG0583	DNA-binding transcription factor activity
I6K37_RS10095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS10120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS10125	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K37_RS10130	COG2814	Major facilitator Superfamily
I6K37_RS10135	COG1285	pathogenesis
I6K37_RS10140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K37_RS10160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K37_RS10160	COG0519	Catalyzes the synthesis of GMP from XMP
I6K37_RS10200	COG0596	Alpha beta hydrolase
I6K37_RS10210	COG2205	protein histidine kinase activity
I6K37_RS10225	COG0076	glutamate decarboxylase activity
I6K37_RS10230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K37_RS10235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K37_RS10240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K37_RS10245	COG1116	anion transmembrane transporter activity
I6K37_RS10250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K37_RS10265	COG0673	inositol 2-dehydrogenase activity
I6K37_RS10275	COG1609	Transcriptional regulator
I6K37_RS10280	COG3706	GGDEF domain
I6K37_RS10285	COG0402	S-adenosylhomocysteine deaminase activity
I6K37_RS10290	COG1953	Uracil, thiamine, allantoin
I6K37_RS10325	COG0596	Alpha beta hydrolase
I6K37_RS10335	COG2207	Transcriptional regulator
I6K37_RS10350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K37_RS10375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K37_RS10420	COG0765	amino acid transport
I6K37_RS10430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K37_RS10440	COG2070	2-Nitropropane dioxygenase
I6K37_RS10445	COG0583	DNA-binding transcription factor activity
I6K37_RS10455	COG1902	pentaerythritol trinitrate reductase activity
I6K37_RS10460	COG4529	Protein conserved in bacteria
I6K37_RS10465	COG0477	Major facilitator Superfamily
I6K37_RS10495	COG2223	nitrite transmembrane transporter activity
I6K37_RS10505	COG1609	Transcriptional regulator
I6K37_RS10510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS10520	COG3037	sugar-specific permease SgaT UlaA
I6K37_RS10525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K37_RS10535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS10540	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K37_RS10540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS10540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS10555	COG0583	DNA-binding transcription factor activity
I6K37_RS10560	COG0583	DNA-binding transcription factor activity
I6K37_RS10565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K37_RS10575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K37_RS10590	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS10600	COG1609	Transcriptional regulator
I6K37_RS10630	COG1652	LysM domain
I6K37_RS10655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K37_RS10655	COG0456	acetyltransferase
I6K37_RS10665	COG0667	Aldo Keto reductase
I6K37_RS10670	COG0667	Aldo Keto reductase
I6K37_RS10675	COG3386	PFAM SMP-30 Gluconolaconase
I6K37_RS10680	COG0667	Aldo Keto reductase
I6K37_RS10710	COG0251	oxidation-reduction process
I6K37_RS10715	COG0583	DNA-binding transcription factor activity
I6K37_RS10720	COG0626	cystathionine gamma-synthase activity
I6K37_RS10725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K37_RS10730	COG0814	amino acid
I6K37_RS10735	COG0583	DNA-binding transcription factor activity
I6K37_RS10745	COG1294	oxidase, subunit
I6K37_RS10750	COG1271	oxidase subunit
I6K37_RS10760	COG3118	belongs to the thioredoxin family
I6K37_RS10790	COG0583	DNA-binding transcription factor activity
I6K37_RS10830	COG1929	Belongs to the glycerate kinase type-1 family
I6K37_RS10835	COG3835	regulator
I6K37_RS10845	COG0583	DNA-binding transcription factor activity
I6K37_RS10855	COG2186	Transcriptional regulator
I6K37_RS10860	COG1263	PTS System
I6K37_RS10860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K37_RS10870	COG2814	Major facilitator Superfamily
I6K37_RS10875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS10875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS10890	COG2819	hydrolase of the alpha beta superfamily
I6K37_RS10895	COG3300	MHYT domain
I6K37_RS10895	COG5001	Diguanylate cyclase
I6K37_RS10930	COG3188	usher protein
I6K37_RS10940	COG1649	PFAM Uncharacterised BCR, COG1649
I6K37_RS10945	COG3550	peptidyl-serine autophosphorylation
I6K37_RS10950	COG1396	sequence-specific DNA binding
I6K37_RS10955	COG2351	hydroxyisourate hydrolase activity
I6K37_RS10960	COG3648	Uricase
I6K37_RS10960	COG3195	allantoin biosynthetic process
I6K37_RS10965	COG2233	PERMEase
I6K37_RS10995	COG2207	Transcriptional regulator
I6K37_RS11010	COG4628	conserved protein (DUF2132)
I6K37_RS11030	COG2011	ABC-type metal ion transport system permease component
I6K37_RS11035	COG2070	2-Nitropropane dioxygenase
I6K37_RS11045	COG0477	Major facilitator Superfamily
I6K37_RS11110	COG2199	diguanylate cyclase activity
I6K37_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS11130	COG0583	DNA-binding transcription factor activity
I6K37_RS11140	COG0039	L-malate dehydrogenase activity
I6K37_RS11145	COG1349	DNA-binding transcription factor activity
I6K37_RS11150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K37_RS11155	COG3395	kinase activity
I6K37_RS11165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K37_RS11170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K37_RS11175	COG2271	Major facilitator Superfamily
I6K37_RS11205	COG4977	sequence-specific DNA binding
I6K37_RS11215	COG0697	spore germination
I6K37_RS11220	COG2814	Major facilitator Superfamily
I6K37_RS11250	COG0683	leucine binding
I6K37_RS11255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K37_RS11290	COG2223	nitrite transmembrane transporter activity
I6K37_RS11295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K37_RS11310	COG1349	DNA-binding transcription factor activity
I6K37_RS11315	COG2084	Dehydrogenase
I6K37_RS11320	COG3395	kinase activity
I6K37_RS11325	COG0235	Class ii aldolase
I6K37_RS11330	COG3622	Belongs to the hyi family
I6K37_RS11335	COG2610	gluconate transmembrane transporter activity
I6K37_RS11340	COG2207	Transcriptional regulator
I6K37_RS11340	COG3708	Transcriptional regulator
I6K37_RS11355	COG2200	EAL domain
I6K37_RS11360	COG1546	Belongs to the CinA family
I6K37_RS11365	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K37_RS11380	COG2197	response regulator
I6K37_RS11395	COG2135	peptidase activity
I6K37_RS11400	COG2207	Transcriptional regulator
I6K37_RS11415	COG4221	oxidoreductase activity
I6K37_RS11420	COG1802	Transcriptional regulator
I6K37_RS11425	COG0589	response to stress
I6K37_RS11430	COG0246	Mannitol dehydrogenase
I6K37_RS11435	COG2271	Major facilitator Superfamily
I6K37_RS11450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K37_RS11465	COG0243	molybdopterin cofactor binding
I6K37_RS11470	COG0437	4 iron, 4 sulfur cluster binding
I6K37_RS11475	COG3302	dmso reductase anchor subunit
I6K37_RS11490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K37_RS11495	COG1940	carbohydrate kinase activity
I6K37_RS11500	COG0583	DNA-binding transcription factor activity
I6K37_RS11505	COG2814	Major facilitator Superfamily
I6K37_RS11510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K37_RS11520	COG3591	Belongs to the peptidase S1B family
I6K37_RS11540	COG0628	permease
I6K37_RS11570	COG0679	Auxin Efflux Carrier
I6K37_RS11580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K37_RS11605	COG3290	protein histidine kinase activity
I6K37_RS11610	COG4565	transcriptional regulatory protein
I6K37_RS11630	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K37_RS11630	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K37_RS11640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K37_RS11645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K37_RS11655	COG0183	Belongs to the thiolase family
I6K37_RS11660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K37_RS11670	COG1414	Transcriptional regulator
I6K37_RS11675	COG2840	Smr protein MutS2
I6K37_RS11680	COG0583	DNA-binding transcription factor activity
I6K37_RS11690	COG1473	amidohydrolase
I6K37_RS11695	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K37_RS11710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K37_RS11725	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K37_RS11730	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K37_RS11745	COG0531	amino acid
I6K37_RS11755	COG3136	membrane protein required for alginate biosynthesis
I6K37_RS11760	COG0745	RESPONSE REGULATOR receiver
I6K37_RS11770	COG2205	protein histidine kinase activity
I6K37_RS11780	COG0114	fumarate hydratase activity
I6K37_RS11785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K37_RS11785	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K37_RS11790	COG1482	cell wall glycoprotein biosynthetic process
I6K37_RS11795	COG5339	Protein conserved in bacteria
I6K37_RS11800	COG1609	Transcriptional regulator
I6K37_RS11805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K37_RS11805	COG1263	PTS System
I6K37_RS11810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K37_RS11835	COG2391	methyltransferase activity
I6K37_RS11840	COG0425	Belongs to the sulfur carrier protein TusA family
I6K37_RS11845	COG5562	phage envelope protein
I6K37_RS11850	COG0401	homolog of Blt101
I6K37_RS11855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K37_RS11860	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS11870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K37_RS11875	COG0477	Major facilitator Superfamily
I6K37_RS11880	COG1113	amino acid transport
I6K37_RS11885	COG2988	succinylglutamate desuccinylase activity
I6K37_RS11890	COG3724	N-succinylarginine dihydrolase activity
I6K37_RS11895	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS11900	COG3138	arginine N-succinyltransferase
I6K37_RS11905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K37_RS11915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K37_RS11920	COG0667	Aldo Keto reductase
I6K37_RS11925	COG0583	DNA-binding transcription factor activity
I6K37_RS11950	COG4122	O-methyltransferase activity
I6K37_RS11955	COG1643	Atp-dependent helicase
I6K37_RS11970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K37_RS11975	COG3327	negative regulation of DNA-templated transcription, initiation
I6K37_RS11980	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K37_RS11985	COG0183	Belongs to the thiolase family
I6K37_RS11990	COG2050	protein possibly involved in aromatic compounds catabolism
I6K37_RS11995	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K37_RS12000	COG1024	Enoyl-CoA hydratase
I6K37_RS12005	COG1024	Enoyl-CoA hydratase
I6K37_RS12010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K37_RS12015	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K37_RS12020	COG3396	Phenylacetate-CoA oxygenase
I6K37_RS12025	COG3460	Phenylacetate-CoA oxygenase
I6K37_RS12030	COG3396	Phenylacetate-CoA oxygenase
I6K37_RS12035	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS12035	COG2030	dehydratase
I6K37_RS12055	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS12060	COG2207	Transcriptional regulator
I6K37_RS12065	COG3784	Protein of unknown function (DUF1318)
I6K37_RS12075	COG2911	Protein conserved in bacteria
I6K37_RS12080	COG0586	Pfam SNARE associated Golgi protein
I6K37_RS12085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K37_RS12090	COG3187	Heat shock protein
I6K37_RS12095	COG3042	response to heat
I6K37_RS12100	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K37_RS12100	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K37_RS12100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K37_RS12100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K37_RS12105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K37_RS12115	COG0589	response to stress
I6K37_RS12125	COG0513	Belongs to the DEAD box helicase family
I6K37_RS12135	COG1349	DNA-binding transcription factor activity
I6K37_RS12140	COG0673	inositol 2-dehydrogenase activity
I6K37_RS12155	COG1113	amino acid transport
I6K37_RS12160	COG1522	sequence-specific DNA binding
I6K37_RS12170	COG1448	Aminotransferase
I6K37_RS12175	COG2011	ABC-type metal ion transport system permease component
I6K37_RS12185	COG1464	Belongs to the NlpA lipoprotein family
I6K37_RS12190	COG0436	Aminotransferase
I6K37_RS12195	COG0604	alcohol dehydrogenase
I6K37_RS12225	COG0583	DNA-binding transcription factor activity
I6K37_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS12250	COG1309	transcriptional regulator
I6K37_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS12370	COG2885	chlorophyll binding
I6K37_RS12395	COG0693	protein deglycase activity
I6K37_RS12400	COG1078	dGTPase activity
I6K37_RS12405	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS12410	COG0583	DNA-binding transcription factor activity
I6K37_RS12470	COG0784	Response regulator, receiver
I6K37_RS12470	COG5002	protein histidine kinase activity
I6K37_RS12470	COG2205	protein histidine kinase activity
I6K37_RS12475	COG3250	beta-galactosidase activity
I6K37_RS12480	COG0656	L-ascorbic acid biosynthetic process
I6K37_RS12510	COG4166	transmembrane transport
I6K37_RS12520	COG2866	Carboxypeptidase
I6K37_RS12525	COG4948	Mandelate Racemase Muconate Lactonizing
I6K37_RS12530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K37_RS12535	COG3180	Ammonia monooxygenase
I6K37_RS12545	COG1486	melibiose metabolic process
I6K37_RS12550	COG0583	DNA-binding transcription factor activity
I6K37_RS12560	COG3106	COG3106 Predicted ATPase
I6K37_RS12570	COG1983	PspC domain protein
I6K37_RS12580	COG1842	Phage shock protein A
I6K37_RS12585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K37_RS12595	COG1473	amidohydrolase
I6K37_RS12610	COG0702	epimerase
I6K37_RS12625	COG2135	peptidase activity
I6K37_RS12640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K37_RS12645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K37_RS12705	COG1196	nuclear chromosome segregation
I6K37_RS12790	COG5484	DNA packaging
I6K37_RS12790	COG3728	DNA packaging
I6K37_RS12830	COG3179	chitinase
I6K37_RS12845	COG3477	response to acidic pH
I6K37_RS12910	COG1484	DNA-dependent DNA replication
I6K37_RS12950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K37_RS12980	COG4171	peptide transport system, permease
I6K37_RS12995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K37_RS13005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K37_RS13010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K37_RS13010	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K37_RS13025	COG1349	DNA-binding transcription factor activity
I6K37_RS13035	COG0023	Translation Initiation Factor
I6K37_RS13045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K37_RS13050	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K37_RS13055	COG0671	phosphoesterase, PA-phosphatase related
I6K37_RS13065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K37_RS13090	COG0616	signal peptide processing
I6K37_RS13100	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS13105	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K37_RS13135	COG0583	DNA-binding transcription factor activity
I6K37_RS13145	COG0009	L-threonylcarbamoyladenylate synthase
I6K37_RS13155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K37_RS13160	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K37_RS13160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K37_RS13165	COG0134	indole-3-glycerol-phosphate synthase activity
I6K37_RS13165	COG0135	phosphoribosylanthranilate isomerase activity
I6K37_RS13220	COG4774	siderophore transport
I6K37_RS13230	COG3047	cAMP biosynthetic process
I6K37_RS13235	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K37_RS13265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K37_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS13275	COG1988	membrane-bound metal-dependent
I6K37_RS13280	COG1823	symporter activity
I6K37_RS13290	COG0753	catalase activity
I6K37_RS13300	COG1486	melibiose metabolic process
I6K37_RS13305	COG1917	Cupin 2, conserved barrel domain protein
I6K37_RS13305	COG2169	Transcriptional regulator
I6K37_RS13310	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K37_RS13315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS13325	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS13330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K37_RS13340	COG0322	excinuclease ABC activity
I6K37_RS13345	COG3678	ATP-independent chaperone mediated protein folding
I6K37_RS13355	COG3724	N-succinylarginine dihydrolase activity
I6K37_RS13365	COG3138	arginine N-succinyltransferase
I6K37_RS13375	COG0708	Exodeoxyribonuclease III
I6K37_RS13380	COG0398	Pfam SNARE associated Golgi protein
I6K37_RS13385	COG0398	Pfam SNARE associated Golgi protein
I6K37_RS13390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K37_RS13395	COG4134	Bacterial extracellular solute-binding protein
I6K37_RS13400	COG4135	transport system, permease component
I6K37_RS13405	COG4136	ATPase activity
I6K37_RS13410	COG2897	thiosulfate sulfurtransferase activity
I6K37_RS13415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K37_RS13420	COG0494	nUDIX hydrolase
I6K37_RS13425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K37_RS13430	COG0604	alcohol dehydrogenase
I6K37_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS13430	COG3321	synthase
I6K37_RS13435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K37_RS13440	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K37_RS13450	COG0778	Nitroreductase
I6K37_RS13455	COG0616	signal peptide processing
I6K37_RS13460	COG0252	asparaginase activity
I6K37_RS13465	COG1335	isochorismatase
I6K37_RS13480	COG3139	Protein of unknown function (DUF1315)
I6K37_RS13500	COG0656	L-ascorbic acid biosynthetic process
I6K37_RS13505	COG3713	MltA-interacting MipA family protein
I6K37_RS13510	COG2766	serine protein kinase
I6K37_RS13525	COG0386	Belongs to the glutathione peroxidase family
I6K37_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS13555	COG0583	DNA-binding transcription factor activity
I6K37_RS13560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K37_RS13565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K37_RS13575	COG0859	PFAM glycosyl transferase family 9
I6K37_RS13580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K37_RS13590	COG2207	Transcriptional regulator
I6K37_RS13595	COG2807	transmembrane transport
I6K37_RS13600	COG0504	CTP synthase activity
I6K37_RS13605	COG1683	Conserved Protein
I6K37_RS13610	COG3189	MarR family transcriptional regulator
I6K37_RS13615	COG3042	response to heat
I6K37_RS13750	COG4695	Portal protein
I6K37_RS13770	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K37_RS13810	COG4974	Belongs to the 'phage' integrase family
I6K37_RS13815	COG2203	Gaf domain
I6K37_RS13815	COG2199	diguanylate cyclase activity
I6K37_RS13835	COG3182	Iron-regulated membrane protein
I6K37_RS13845	COG1560	Kdo2-lipid A biosynthetic process
I6K37_RS13855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K37_RS13860	COG3706	GGDEF domain
I6K37_RS13865	COG0583	DNA-binding transcription factor activity
I6K37_RS13870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K37_RS13900	COG1294	oxidase, subunit
I6K37_RS13905	COG1271	oxidase subunit
I6K37_RS13910	COG3546	catalase activity
I6K37_RS13915	COG3685	Protein conserved in bacteria
I6K37_RS13920	COG3685	Protein conserved in bacteria
I6K37_RS13925	COG3729	General stress protein
I6K37_RS13930	COG1063	alcohol dehydrogenase
I6K37_RS13935	COG3813	Protein conserved in bacteria
I6K37_RS13955	COG0640	Transcriptional regulator
I6K37_RS13960	COG0538	isocitrate dehydrogenase activity
I6K37_RS13965	COG1187	pseudouridine synthase activity
I6K37_RS13985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K37_RS14005	COG2205	protein histidine kinase activity
I6K37_RS14010	COG2850	peptidyl-arginine hydroxylation
I6K37_RS14030	COG1177	transmembrane transport
I6K37_RS14045	COG0318	PFAM AMP-dependent synthetase and ligase
I6K37_RS14050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K37_RS14055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K37_RS14060	COG0698	ribose 5-phosphate isomerase
I6K37_RS14075	COG3395	kinase activity
I6K37_RS14090	COG2390	Transcriptional regulator
I6K37_RS14100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K37_RS14110	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K37_RS14120	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K37_RS14130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K37_RS14135	COG1388	LysM domain
I6K37_RS14135	COG1376	ErfK ybiS ycfS ynhG family protein
I6K37_RS14150	COG1309	transcriptional regulator
I6K37_RS14165	COG3134	Outer membrane lipoprotein
I6K37_RS14170	COG1252	NADH dehydrogenase
I6K37_RS14195	COG5633	Lipoprotein
I6K37_RS14200	COG0537	adenosine 5'-monophosphoramidase activity
I6K37_RS14210	COG0084	hydrolase, TatD family'
I6K37_RS14215	COG0470	DNA polymerase III
I6K37_RS14225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K37_RS14230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K37_RS14235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K37_RS14250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K37_RS14270	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K37_RS14290	COG1530	ribonuclease E activity
I6K37_RS14295	COG0583	DNA-binding transcription factor activity
I6K37_RS14300	COG2814	Major facilitator Superfamily
I6K37_RS14320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K37_RS14365	COG1560	Kdo2-lipid A biosynthetic process
I6K37_RS14380	COG5645	(Lipo)protein
I6K37_RS14415	COG3381	protein complex oligomerization
I6K37_RS14440	COG0583	DNA-binding transcription factor activity
I6K37_RS14450	COG1335	isochorismatase
I6K37_RS14460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K37_RS14465	COG1702	phosphate starvation-inducible protein PhoH
I6K37_RS14485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K37_RS14495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K37_RS14510	COG1309	transcriptional regulator
I6K37_RS14545	COG2233	PERMEase
I6K37_RS14555	COG3729	General stress protein
I6K37_RS14585	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS14600	COG0531	amino acid
I6K37_RS14605	COG0174	glutamine synthetase
I6K37_RS14610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K37_RS14615	COG1396	sequence-specific DNA binding
I6K37_RS14615	COG1917	Cupin 2, conserved barrel domain protein
I6K37_RS14620	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS14625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K37_RS14630	COG0583	DNA-binding transcription factor activity
I6K37_RS14635	COG0473	3-isopropylmalate dehydrogenase activity
I6K37_RS14640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K37_RS14645	COG4638	Rieske (2fe-2S)
I6K37_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS14655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K37_RS14660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K37_RS14660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS14660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS14665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS14670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS14675	COG1882	Formate acetyltransferase
I6K37_RS14680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K37_RS14685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K37_RS14695	COG2207	Transcriptional regulator
I6K37_RS14700	COG3706	GGDEF domain
I6K37_RS14720	COG2200	EAL domain
I6K37_RS14730	COG0058	SHG alpha-glucan phosphorylase activity
I6K37_RS14745	COG0670	Belongs to the BI1 family
I6K37_RS14760	COG2207	Transcriptional regulator
I6K37_RS14765	COG1881	PFAM PEBP family protein
I6K37_RS14790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS14795	COG2274	protein secretion by the type I secretion system
I6K37_RS14810	COG1832	CoA-binding protein
I6K37_RS14820	COG0210	DNA helicase
I6K37_RS14825	COG3304	Inner membrane component domain
I6K37_RS14830	COG1289	transmembrane transporter activity
I6K37_RS14835	COG3070	regulator of competence-specific genes
I6K37_RS14855	COG1067	ATP-dependent peptidase activity
I6K37_RS14865	COG3130	regulation of translation
I6K37_RS14870	COG3009	Protein conserved in bacteria
I6K37_RS14875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K37_RS14875	COG3008	intermembrane lipid transfer
I6K37_RS14880	COG2995	paraquat-inducible protein a
I6K37_RS14885	COG0488	(ABC) transporter
I6K37_RS14895	COG3217	Mosc domain protein beta barrel domain protein
I6K37_RS14895	COG0633	Ferredoxin
I6K37_RS14910	COG0431	NADPH-dependent FMN reductase
I6K37_RS14915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K37_RS14920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K37_RS14925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K37_RS14935	COG0308	aminopeptidase N
I6K37_RS14945	COG1473	amidohydrolase
I6K37_RS14955	COG0814	amino acid
I6K37_RS14975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K37_RS14980	COG1448	Aminotransferase
I6K37_RS14985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K37_RS14990	COG3108	Peptidase M15
I6K37_RS14995	COG2989	Protein conserved in bacteria
I6K37_RS15005	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K37_RS15015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K37_RS15020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K37_RS15025	COG3173	Aminoglycoside phosphotransferase
I6K37_RS15040	COG3214	Protein conserved in bacteria
I6K37_RS15055	COG2333	competence protein COMEC
I6K37_RS15055	COG0658	competence protein
I6K37_RS15065	COG0539	negative regulation of cytoplasmic translation
I6K37_RS15085	COG2323	membrane
I6K37_RS15090	COG1944	ATP diphosphatase activity
I6K37_RS15095	COG2116	formate transmembrane transporter activity
I6K37_RS15100	COG1882	Formate acetyltransferase
I6K37_RS15105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K37_RS15110	COG0477	Major facilitator Superfamily
I6K37_RS15115	COG3302	dmso reductase anchor subunit
I6K37_RS15120	COG0437	4 iron, 4 sulfur cluster binding
I6K37_RS15125	COG0243	molybdopterin cofactor binding
I6K37_RS15135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K37_RS15145	COG1178	ABC-type Fe3 transport system permease component
I6K37_RS15145	COG1674	ftsk spoiiie
I6K37_RS15155	COG0492	ferredoxin-NADP+ reductase activity
I6K37_RS15160	COG4988	ABC transporter
I6K37_RS15165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K37_RS15180	COG0542	response to heat
I6K37_RS15190	COG1278	Cold shock
I6K37_RS15200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS15205	COG3593	DNA synthesis involved in DNA repair
I6K37_RS15215	COG2431	L-lysine efflux transmembrane transporter activity
I6K37_RS15225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K37_RS15235	COG0028	Belongs to the TPP enzyme family
I6K37_RS15240	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K37_RS15245	COG0702	epimerase
I6K37_RS15250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K37_RS15255	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K37_RS15260	COG4251	negative regulation of phosphorylation
I6K37_RS15260	COG5001	Diguanylate cyclase
I6K37_RS15260	COG3706	GGDEF domain
I6K37_RS15260	COG2203	Gaf domain
I6K37_RS15270	COG1126	abc transporter atp-binding protein
I6K37_RS15275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS15280	COG4215	(ABC) transporter
I6K37_RS15285	COG4160	amino acid transport
I6K37_RS15290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS15295	COG5002	protein histidine kinase activity
I6K37_RS15300	COG0745	RESPONSE REGULATOR receiver
I6K37_RS15315	COG1177	transmembrane transport
I6K37_RS15320	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K37_RS15325	COG3842	ATPase activity
I6K37_RS15330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K37_RS15345	COG0778	Nitroreductase
I6K37_RS15370	COG3226	Transcriptional regulator
I6K37_RS15375	COG0738	Major facilitator superfamily
I6K37_RS15380	COG0561	phosphatase activity
I6K37_RS15385	COG2814	Major facilitator Superfamily
I6K37_RS15390	COG0671	phosphoesterase, PA-phosphatase related
I6K37_RS15395	COG1349	DNA-binding transcription factor activity
I6K37_RS15400	COG1686	Belongs to the peptidase S11 family
I6K37_RS15410	COG0625	glutathione transferase activity
I6K37_RS15415	COG2133	pyrroloquinoline quinone binding
I6K37_RS15425	COG2223	nitrite transmembrane transporter activity
I6K37_RS15445	COG0747	negative chemotaxis
I6K37_RS15460	COG0303	'Molybdopterin
I6K37_RS15465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K37_RS15470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K37_RS15475	COG1882	Formate acetyltransferase
I6K37_RS15480	COG0561	phosphatase activity
I6K37_RS15490	COG1609	Transcriptional regulator
I6K37_RS15495	COG2271	Major facilitator Superfamily
I6K37_RS15505	COG0488	(ABC) transporter
I6K37_RS15510	COG2365	Tyrosine phosphatase family
I6K37_RS15515	COG1376	ErfK ybiS ycfS ynhG family protein
I6K37_RS15520	COG2188	Transcriptional regulator
I6K37_RS15525	COG2723	6-phospho-beta-galactosidase activity
I6K37_RS15530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K37_RS15545	COG2194	sulfuric ester hydrolase activity
I6K37_RS15550	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K37_RS15565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS15570	COG0765	amino acid transport
I6K37_RS15575	COG1126	abc transporter atp-binding protein
I6K37_RS15580	COG0668	transmembrane transport
I6K37_RS15590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K37_RS15600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K37_RS15610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K37_RS15615	COG1199	ATP-dependent helicase activity
I6K37_RS15620	COG0513	Belongs to the DEAD box helicase family
I6K37_RS15625	COG3958	Transketolase
I6K37_RS15630	COG3959	Transketolase, thiamine diphosphate binding domain
I6K37_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS15640	COG2271	Major facilitator Superfamily
I6K37_RS15650	COG0583	DNA-binding transcription factor activity
I6K37_RS15655	COG1309	transcriptional regulator
I6K37_RS15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS15665	COG1131	(ABC) transporter
I6K37_RS15670	COG0842	Transport permease protein
I6K37_RS15675	COG0842	Transport permease protein
I6K37_RS15685	COG3568	Endonuclease Exonuclease Phosphatase
I6K37_RS15690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K37_RS15695	COG0392	lysyltransferase activity
I6K37_RS15700	COG0670	Belongs to the BI1 family
I6K37_RS15705	COG0314	molybdopterin synthase activity
I6K37_RS15710	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K37_RS15720	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K37_RS15740	COG0745	RESPONSE REGULATOR receiver
I6K37_RS15745	COG0642	Histidine kinase
I6K37_RS15770	COG2226	methyltransferase
I6K37_RS15785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K37_RS15790	COG1881	PFAM PEBP family protein
I6K37_RS15830	COG4677	pectinesterase activity
I6K37_RS15840	COG0589	response to stress
I6K37_RS15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS15880	COG0789	Transcriptional regulator
I6K37_RS15885	COG2200	EAL domain
I6K37_RS15910	COG0561	phosphatase activity
I6K37_RS15920	COG4149	molybdate abc transporter
I6K37_RS15925	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K37_RS15935	COG3585	molybdate ion transport
I6K37_RS15935	COG2005	Transcriptional regulator
I6K37_RS15940	COG1119	ATPase activity
I6K37_RS15950	COG1085	galactose-1-phosphate uridylyltransferase
I6K37_RS15960	COG2017	converts alpha-aldose to the beta-anomer
I6K37_RS15970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K37_RS15985	COG3201	nicotinamide mononucleotide transporter
I6K37_RS15990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K37_RS16035	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K37_RS16040	COG2885	chlorophyll binding
I6K37_RS16050	COG3064	Membrane
I6K37_RS16055	COG0848	biopolymer transport protein
I6K37_RS16060	COG0811	peptide transport
I6K37_RS16065	COG0824	Thioesterase
I6K37_RS16070	COG3790	cyd operon protein YbgE
I6K37_RS16075	COG4890	Cyd operon protein YbgT
I6K37_RS16080	COG1294	oxidase, subunit
I6K37_RS16085	COG1271	oxidase subunit
I6K37_RS16090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K37_RS16100	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K37_RS16105	COG0567	Dehydrogenase, E1 component
I6K37_RS16110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K37_RS16115	COG1053	succinate dehydrogenase
I6K37_RS16120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K37_RS16125	COG2009	succinate dehydrogenase
I6K37_RS16160	COG1984	allophanate hydrolase subunit 2
I6K37_RS16165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K37_RS16180	COG0415	Belongs to the DNA photolyase family
I6K37_RS16210	COG2205	protein histidine kinase activity
I6K37_RS16215	COG0745	RESPONSE REGULATOR receiver
I6K37_RS16225	COG0033	Phosphoglucomutase
I6K37_RS16235	COG0596	Alpha beta hydrolase
I6K37_RS16250	COG0735	belongs to the Fur family
I6K37_RS16290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K37_RS16295	COG1846	Transcriptional regulator
I6K37_RS16295	COG1940	carbohydrate kinase activity
I6K37_RS16300	COG0647	UMP catabolic process
I6K37_RS16305	COG0367	asparagine synthase
I6K37_RS16345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K37_RS16355	COG1702	phosphate starvation-inducible protein PhoH
I6K37_RS16380	COG0765	amino acid transport
I6K37_RS16385	COG0765	amino acid transport
I6K37_RS16390	COG1126	abc transporter atp-binding protein
I6K37_RS16405	COG2888	peptidyl-tyrosine sulfation
I6K37_RS16420	COG1466	dna polymerase III delta subunit
I6K37_RS16435	COG0799	negative regulation of ribosome biogenesis
I6K37_RS16445	COG0768	penicillin binding
I6K37_RS16450	COG0772	Belongs to the SEDS family
I6K37_RS16455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K37_RS16460	COG1686	Belongs to the peptidase S11 family
I6K37_RS16475	COG0583	DNA-binding transcription factor activity
I6K37_RS16485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K37_RS16490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K37_RS16510	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K37_RS16515	COG3719	Belongs to the RNase T2 family
I6K37_RS16520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K37_RS16540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K37_RS16545	COG0583	DNA-binding transcription factor activity
I6K37_RS16550	COG3969	phosphoadenosine phosphosulfate
I6K37_RS16555	COG1475	DNA binding
I6K37_RS16560	COG0436	Aminotransferase
I6K37_RS16585	COG1129	ABC transporter
I6K37_RS16590	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS16595	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS16605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K37_RS16620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K37_RS16630	COG0402	S-adenosylhomocysteine deaminase activity
I6K37_RS16640	COG0483	inositol monophosphate 1-phosphatase activity
I6K37_RS16645	COG2271	Major facilitator Superfamily
I6K37_RS16675	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS16680	COG1129	ABC transporter
I6K37_RS16685	COG0371	Dehydrogenase
I6K37_RS16690	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS16705	COG2879	small protein
I6K37_RS16710	COG1966	Carbon starvation protein
I6K37_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS16725	COG1535	isochorismatase
I6K37_RS16725	COG3433	isochorismatase activity
I6K37_RS16730	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K37_RS16735	COG1169	isochorismate synthase
I6K37_RS16740	COG4592	Periplasmic binding protein
I6K37_RS16750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS16755	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS16760	COG1120	ATPase activity
I6K37_RS16765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K37_RS16765	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K37_RS16770	COG3251	PFAM MbtH domain protein
I6K37_RS16775	COG2382	esterase
I6K37_RS16780	COG4771	TonB-dependent receptor
I6K37_RS16790	COG1879	ABC-type sugar transport system periplasmic component
I6K37_RS16800	COG1129	ABC transporter
I6K37_RS16805	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS16810	COG5464	transposase or invertase
I6K37_RS16815	COG2390	Transcriptional regulator
I6K37_RS16820	COG3959	Transketolase, thiamine diphosphate binding domain
I6K37_RS16825	COG3958	Transketolase
I6K37_RS16835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K37_RS16845	COG0583	DNA-binding transcription factor activity
I6K37_RS16850	COG0668	transmembrane transport
I6K37_RS16860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K37_RS16885	COG0747	negative chemotaxis
I6K37_RS16890	COG0601	transmembrane transport
I6K37_RS16895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS16900	COG0444	Belongs to the ABC transporter superfamily
I6K37_RS16905	COG4608	Belongs to the ABC transporter superfamily
I6K37_RS16910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K37_RS16915	COG4221	oxidoreductase activity
I6K37_RS16925	COG4215	(ABC) transporter
I6K37_RS16930	COG0765	amino acid transport
I6K37_RS16935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K37_RS16950	COG0697	spore germination
I6K37_RS16965	COG4608	Belongs to the ABC transporter superfamily
I6K37_RS16970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS16980	COG4166	transmembrane transport
I6K37_RS16990	COG3698	Phosphodiester glycosidase
I6K37_RS17030	COG2315	Protein conserved in bacteria
I6K37_RS17035	COG0778	Nitroreductase
I6K37_RS17060	COG0477	Major facilitator Superfamily
I6K37_RS17065	COG0668	transmembrane transport
I6K37_RS17070	COG1609	Transcriptional regulator
I6K37_RS17080	COG0673	inositol 2-dehydrogenase activity
I6K37_RS17090	COG2211	Major facilitator Superfamily
I6K37_RS17095	COG1113	amino acid transport
I6K37_RS17110	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS17115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K37_RS17125	COG0531	amino acid
I6K37_RS17140	COG4680	protein conserved in bacteria
I6K37_RS17180	COG0667	Aldo Keto reductase
I6K37_RS17185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS17190	COG1473	amidohydrolase
I6K37_RS17220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS17225	COG1120	ATPase activity
I6K37_RS17230	COG1566	PFAM secretion protein HlyD family protein
I6K37_RS17275	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS17280	COG1129	ABC transporter
I6K37_RS17295	COG0673	inositol 2-dehydrogenase activity
I6K37_RS17325	COG3104	oligopeptide transport
I6K37_RS17330	COG1982	Orn Lys Arg decarboxylase major
I6K37_RS17335	COG0531	amino acid
I6K37_RS17340	COG3710	Transcriptional regulator
I6K37_RS17350	COG1560	Kdo2-lipid A biosynthetic process
I6K37_RS17490	COG3561	AntA/AntB antirepressor
I6K37_RS17510	COG0582	viral genome integration into host DNA
I6K37_RS17525	COG2501	S4 domain
I6K37_RS17535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K37_RS17550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K37_RS17555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K37_RS17575	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K37_RS17580	COG4181	ATPase activity
I6K37_RS17585	COG2755	lipolytic protein G-D-S-L family
I6K37_RS17590	COG0300	oxidoreductase activity
I6K37_RS17595	COG3118	belongs to the thioredoxin family
I6K37_RS17600	COG0390	transport system, permease component
I6K37_RS17605	COG4619	ABC transporter
I6K37_RS17610	COG0330	HflC and HflK could
I6K37_RS17615	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K37_RS17630	COG3735	TraB family
I6K37_RS17635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K37_RS17645	COG2223	nitrite transmembrane transporter activity
I6K37_RS17650	COG4651	solute:proton antiporter activity
I6K37_RS17650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K37_RS17655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K37_RS17695	COG2832	Protein of unknown function (DUF454)
I6K37_RS17700	COG3923	Primosomal replication protein n
I6K37_RS17710	COG5464	transposase or invertase
I6K37_RS17715	COG1196	nuclear chromosome segregation
I6K37_RS17715	COG3264	Mechanosensitive ion channel
I6K37_RS17720	COG1309	transcriptional regulator
I6K37_RS17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS17730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K37_RS17745	COG0110	maltose O-acetyltransferase activity
I6K37_RS17795	COG1874	Beta-galactosidase
I6K37_RS17800	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K37_RS17805	COG3833	ABC-type maltose transport systems, permease component
I6K37_RS17810	COG1175	transmembrane transport
I6K37_RS17815	COG2182	Extracellular solute-binding protein
I6K37_RS17825	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K37_RS17840	COG2364	Membrane
I6K37_RS17870	COG3695	enzyme binding
I6K37_RS17875	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K37_RS17880	COG1946	Acyl-CoA thioesterase
I6K37_RS17885	COG0004	ammonium transporteR
I6K37_RS17890	COG0347	Belongs to the P(II) protein family
I6K37_RS17895	COG1132	(ABC) transporter
I6K37_RS17900	COG1132	(ABC) transporter
I6K37_RS17905	COG1522	sequence-specific DNA binding
I6K37_RS17920	COG4533	DNA binding
I6K37_RS17930	COG0824	Thioesterase
I6K37_RS17935	COG1555	photosystem II stabilization
I6K37_RS17940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K37_RS17945	COG0776	regulation of translation
I6K37_RS17950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K37_RS17970	COG0271	Belongs to the BolA IbaG family
I6K37_RS17975	COG3056	Lipoprotein
I6K37_RS17980	COG2223	nitrite transmembrane transporter activity
I6K37_RS17985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K37_RS17990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K37_RS17995	COG1845	cytochrome c oxidase, subunit III
I6K37_RS18000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K37_RS18015	COG1414	Transcriptional regulator
I6K37_RS18020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K37_RS18025	COG1053	succinate dehydrogenase
I6K37_RS18035	COG1053	succinate dehydrogenase
I6K37_RS18050	COG0673	inositol 2-dehydrogenase activity
I6K37_RS18055	COG2814	Major facilitator Superfamily
I6K37_RS18065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K37_RS18070	COG0693	protein deglycase activity
I6K37_RS18090	COG0142	geranyltranstransferase activity
I6K37_RS18100	COG0667	Aldo Keto reductase
I6K37_RS18105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K37_RS18125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K37_RS18125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K37_RS18135	COG4238	major outer membrane lipoprotein
I6K37_RS18155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K37_RS18160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K37_RS18165	COG1862	Preprotein translocase
I6K37_RS18190	COG0450	alkyl hydroperoxide reductase
I6K37_RS18200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS18215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K37_RS18225	COG1228	amidohydrolase
I6K37_RS18235	COG1335	isochorismatase
I6K37_RS18240	COG0583	DNA-binding transcription factor activity
I6K37_RS18245	COG0366	Alpha amylase catalytic
I6K37_RS18270	COG0420	3'-5' exonuclease activity
I6K37_RS18275	COG0419	ATPase involved in DNA repair
I6K37_RS18280	COG1940	carbohydrate kinase activity
I6K37_RS18295	COG4126	flavin adenine dinucleotide binding
I6K37_RS18305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K37_RS18310	COG3416	Protein conserved in bacteria
I6K37_RS18320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K37_RS18330	COG1785	Belongs to the alkaline phosphatase family
I6K37_RS18370	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K37_RS18375	COG1335	isochorismatase
I6K37_RS18380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K37_RS18385	COG0113	porphobilinogen synthase activity
I6K37_RS18390	COG1943	Transposase
I6K37_RS18400	COG2175	clavaminate synthase activity
I6K37_RS18405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K37_RS18410	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K37_RS18415	COG4521	taurine ABC transporter
I6K37_RS18420	COG2040	homocysteine
I6K37_RS18425	COG0833	amino acid
I6K37_RS18440	COG4303	Ethanolamine ammonia lyase large subunit
I6K37_RS18445	COG4302	ethanolamine ammonia-lyase activity
I6K37_RS18485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS18490	COG1126	abc transporter atp-binding protein
I6K37_RS18495	COG4597	amino acid ABC transporter
I6K37_RS18500	COG0765	amino acid transport
I6K37_RS18515	COG3188	usher protein
I6K37_RS18540	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K37_RS18550	COG3639	organic phosphonate transmembrane transporter activity
I6K37_RS18565	COG0791	NLP P60 protein
I6K37_RS18590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6K37_RS18615	COG2909	trisaccharide binding
I6K37_RS18620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K37_RS18625	COG0022	dehydrogenase e1 component
I6K37_RS18630	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K37_RS18635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K37_RS18655	COG1070	Carbohydrate kinase
I6K37_RS18660	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS18665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K37_RS18670	COG3775	system Galactitol-specific IIC component
I6K37_RS18675	COG0625	glutathione transferase activity
I6K37_RS18680	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K37_RS18695	COG0579	oxidoreductase
I6K37_RS18700	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS18705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K37_RS18710	COG1113	amino acid transport
I6K37_RS18715	COG1802	Transcriptional regulator
I6K37_RS18735	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K37_RS18740	COG0454	-acetyltransferase
I6K37_RS18755	COG2991	Protein conserved in bacteria
I6K37_RS18770	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K37_RS18775	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K37_RS18790	COG3034	peptidoglycan biosynthetic process
I6K37_RS18795	COG0121	glutamine amidotransferase
I6K37_RS18805	COG1960	acyl-CoA dehydrogenase activity
I6K37_RS18810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K37_RS18820	COG0583	DNA-binding transcription factor activity
I6K37_RS18830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K37_RS18840	COG2226	methyltransferase
I6K37_RS18850	COG1388	LysM domain
I6K37_RS18850	COG0741	lytic transglycosylase activity
I6K37_RS18855	COG2226	methyltransferase
I6K37_RS18865	COG2814	Major facilitator Superfamily
I6K37_RS18870	COG0583	DNA-binding transcription factor activity
I6K37_RS18875	COG0656	L-ascorbic acid biosynthetic process
I6K37_RS18910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K37_RS18920	COG2011	ABC-type metal ion transport system permease component
I6K37_RS18925	COG1464	Belongs to the NlpA lipoprotein family
I6K37_RS18935	COG1720	tRNA m6t6A37 methyltransferase activity
I6K37_RS18945	COG0791	NLP P60 protein
I6K37_RS18950	COG3015	lipoprotein NlpE involved in copper resistance
I6K37_RS18955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K37_RS18970	COG4568	rho-dependent transcription termination
I6K37_RS18980	COG0346	lactoylglutathione lyase activity
I6K37_RS18985	COG1982	Orn Lys Arg decarboxylase major
I6K37_RS18995	COG0587	DNA-directed DNA polymerase activity
I6K37_RS19025	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K37_RS19035	COG0750	zinc metalloprotease
I6K37_RS19040	COG0575	Belongs to the CDS family
I6K37_RS19050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K37_RS19075	COG0024	Methionine aminopeptidase
I6K37_RS19080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K37_RS19095	COG3835	regulator
I6K37_RS19100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K37_RS19120	COG2860	membrane
I6K37_RS19140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS19145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K37_RS19150	COG1120	ATPase activity
I6K37_RS19155	COG4774	siderophore transport
I6K37_RS19160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K37_RS19250	COG1643	Atp-dependent helicase
I6K37_RS19255	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K37_RS19275	COG0617	tRNA 3'-terminal CCA addition
I6K37_RS19280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K37_RS19300	COG0726	polysaccharide deacetylase
I6K37_RS19305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS19310	COG0842	Transport permease protein
I6K37_RS19315	COG1131	(ABC) transporter
I6K37_RS19320	COG0288	reversible hydration of carbon dioxide
I6K37_RS19335	COG4993	Dehydrogenase
I6K37_RS19340	COG2132	Multicopper oxidase
I6K37_RS19385	COG3064	Membrane
I6K37_RS19400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K37_RS19405	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K37_RS19410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K37_RS19415	COG2186	Transcriptional regulator
I6K37_RS19420	COG1113	amino acid transport
I6K37_RS19425	COG2211	Major facilitator Superfamily
I6K37_RS19430	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K37_RS19435	COG3725	Membrane protein required for beta-lactamase induction
I6K37_RS19440	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K37_RS19450	COG4969	Belongs to the N-Me-Phe pilin family
I6K37_RS19455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K37_RS19460	COG1459	type II secretion system
I6K37_RS19485	COG0494	nUDIX hydrolase
I6K37_RS19505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K37_RS19510	COG0849	cell division
I6K37_RS19535	COG0772	Belongs to the SEDS family
I6K37_RS19550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K37_RS19555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K37_RS19560	COG0768	penicillin binding
I6K37_RS19580	COG1609	Transcriptional regulator
I6K37_RS19590	COG0028	Belongs to the TPP enzyme family
I6K37_RS19635	COG0738	Major facilitator superfamily
I6K37_RS19645	COG0583	DNA-binding transcription factor activity
I6K37_RS19650	COG2271	Major facilitator Superfamily
I6K37_RS19655	COG2814	Major facilitator Superfamily
I6K37_RS19675	COG1178	ABC-type Fe3 transport system permease component
I6K37_RS19685	COG0586	Pfam SNARE associated Golgi protein
I6K37_RS19705	COG0235	Class ii aldolase
I6K37_RS19710	COG0417	DNA replication proofreading
I6K37_RS19720	COG0564	pseudouridine synthase activity
I6K37_RS19730	COG3493	citrate carrier protein
I6K37_RS19745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K37_RS19750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K37_RS19760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K37_RS19805	COG0505	Belongs to the CarA family
I6K37_RS19825	COG3152	Membrane
I6K37_RS19840	COG1047	Peptidyl-prolyl cis-trans
I6K37_RS19855	COG0196	riboflavin kinase activity
I6K37_RS19865	COG0583	DNA-binding transcription factor activity
I6K37_RS19890	COG4735	regulation of single-species biofilm formation
I6K37_RS19895	COG1584	GPR1 FUN34 yaaH family protein
I6K37_RS19900	COG0477	Major facilitator Superfamily
I6K37_RS19905	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K37_RS19910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K37_RS19915	COG1115	amino acid carrier protein
I6K37_RS19930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K37_RS19940	COG0460	homoserine dehydrogenase
I6K37_RS19940	COG0527	aspartate kinase activity
I6K37_RS19950	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K37_RS19960	COG0745	RESPONSE REGULATOR receiver
I6K37_RS19965	COG4452	Inner membrane protein CreD
I6K37_RS19970	COG2205	protein histidine kinase activity
I6K37_RS19975	COG0745	RESPONSE REGULATOR receiver
I6K37_RS19980	COG3045	CreA protein
I6K37_RS19985	COG3708	Transcriptional regulator
I6K37_RS19985	COG2207	Transcriptional regulator
I6K37_RS20005	COG0741	lytic transglycosylase activity
I6K37_RS20010	COG0488	(ABC) transporter
I6K37_RS20020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K37_RS20025	COG0560	Phosphoserine phosphatase
I6K37_RS20030	COG3726	membrane protein affecting hemolysin expression
I6K37_RS20060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K37_RS20065	COG0084	hydrolase, TatD family'
I6K37_RS20070	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K37_RS20075	COG5487	UPF0391 membrane protein
I6K37_RS20080	COG2823	Periplasmic or secreted lipoprotein
I6K37_RS20090	COG1011	Hydrolase
I6K37_RS20095	COG0456	acetyltransferase
I6K37_RS20100	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K37_RS20140	COG4114	ferric iron reductase
I6K37_RS20145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS20145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS20150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K37_RS20155	COG2197	response regulator
I6K37_RS20160	COG2197	response regulator
I6K37_RS20175	COG2966	Psort location CytoplasmicMembrane, score
I6K37_RS20190	COG1484	DNA-dependent DNA replication
I6K37_RS20205	COG5464	transposase or invertase
I6K37_RS20215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K37_RS20220	COG3716	PTS system mannose fructose sorbose family IID component
I6K37_RS20225	COG3715	PTS system
I6K37_RS20240	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K37_RS20240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K37_RS20245	COG0456	acetyltransferase
I6K37_RS20245	COG1214	PFAM Peptidase M22, glycoprotease
I6K37_RS20255	COG1737	Transcriptional regulator
I6K37_RS20260	COG0800	Aldolase
I6K37_RS20265	COG3734	2-keto-3-deoxy-galactonokinase
I6K37_RS20280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K37_RS20305	COG1846	Transcriptional regulator
I6K37_RS20315	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K37_RS20325	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS20330	COG3384	dioxygenase
I6K37_RS20340	COG3971	2-oxopent-4-enoate hydratase activity
I6K37_RS20360	COG2368	4-hydroxyphenylacetate
I6K37_RS20365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K37_RS20380	COG1966	Carbon starvation protein
I6K37_RS20385	COG2879	small protein
I6K37_RS20390	COG0523	cobalamin synthesis protein
I6K37_RS20400	COG1012	belongs to the aldehyde dehydrogenase family
I6K37_RS20405	COG5464	transposase or invertase
I6K37_RS20410	COG1917	Cupin 2, conserved barrel domain protein
I6K37_RS20410	COG2207	Transcriptional regulator
I6K37_RS20420	COG2733	membrane
I6K37_RS20435	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K37_RS20440	COG1924	4 iron, 4 sulfur cluster binding
I6K37_RS20455	COG1566	PFAM secretion protein HlyD family protein
I6K37_RS20465	COG5457	Domain of unknown function (DUF1127)
I6K37_RS20470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K37_RS20480	COG0583	DNA-binding transcription factor activity
I6K37_RS20485	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K37_RS20495	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS20500	COG1129	ABC transporter
I6K37_RS20505	COG1879	ABC-type sugar transport system periplasmic component
I6K37_RS20515	COG3706	GGDEF domain
I6K37_RS20520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS20525	COG1129	ABC transporter
I6K37_RS20525	COG0842	Transport permease protein
I6K37_RS20530	COG0842	Transport permease protein
I6K37_RS20560	COG2850	peptidyl-arginine hydroxylation
I6K37_RS20575	COG5002	protein histidine kinase activity
I6K37_RS20580	COG0745	RESPONSE REGULATOR receiver
I6K37_RS20585	COG1538	Outer membrane efflux protein
I6K37_RS20590	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS20595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS20600	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K37_RS20610	COG3040	lipid binding
I6K37_RS20615	COG0789	Transcriptional regulator
I6K37_RS20620	COG3631	Ketosteroid isomerase-related protein
I6K37_RS20625	COG0300	oxidoreductase activity
I6K37_RS20640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K37_RS20660	COG3272	Protein of unknown function (DUF1722)
I6K37_RS20665	COG4580	involved in the transport of maltose and maltodextrins
I6K37_RS20670	COG2115	Belongs to the xylose isomerase family
I6K37_RS20675	COG2211	Major facilitator Superfamily
I6K37_RS20680	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K37_RS20700	COG1216	Glycosyl transferase, family 2
I6K37_RS20750	COG1715	Restriction endonuclease
I6K37_RS20755	COG1196	nuclear chromosome segregation
I6K37_RS20775	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6K37_RS20780	COG0582	viral genome integration into host DNA
I6K37_RS20790	COG0288	reversible hydration of carbon dioxide
I6K37_RS20795	COG0659	secondary active sulfate transmembrane transporter activity
I6K37_RS20800	COG1064	alcohol dehydrogenase
I6K37_RS20805	COG1175	transmembrane transport
I6K37_RS20810	COG0395	ABC-type sugar transport system, permease component
I6K37_RS20815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K37_RS20820	COG3842	ATPase activity
I6K37_RS20835	COG1082	Xylose isomerase domain protein TIM barrel
I6K37_RS20845	COG3962	Belongs to the TPP enzyme family
I6K37_RS20850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K37_RS20855	COG0837	glucose binding
I6K37_RS20855	COG1737	Transcriptional regulator
I6K37_RS20860	COG3718	enzyme involved in inositol metabolism
I6K37_RS20875	COG0433	COG0433 Predicted ATPase
I6K37_RS20880	COG0795	lipopolysaccharide-transporting ATPase activity
I6K37_RS20885	COG0795	lipopolysaccharide-transporting ATPase activity
I6K37_RS20895	COG2927	DNA polymerase III (CHI subunit)
I6K37_RS20900	COG0525	valine-tRNA ligase activity
I6K37_RS20925	COG2731	YhcH YjgK YiaL family protein
I6K37_RS20960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K37_RS20960	COG1263	PTS System
I6K37_RS20965	COG0366	Alpha amylase catalytic
I6K37_RS20970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS20975	COG1486	melibiose metabolic process
I6K37_RS21000	COG0602	queuosine metabolic process
I6K37_RS21005	COG2026	Addiction module toxin, RelE StbE family
I6K37_RS21010	COG3077	Addiction module antitoxin, RelB DinJ family
I6K37_RS21015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K37_RS21015	COG3711	transcriptional antiterminator
I6K37_RS21020	COG2706	6-phosphogluconolactonase activity
I6K37_RS21035	COG3964	amidohydrolase
I6K37_RS21075	COG0312	modulator of DNA gyrase
I6K37_RS21100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K37_RS21110	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS21115	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS21120	COG1129	ABC transporter
I6K37_RS21125	COG1879	ABC-type sugar transport system periplasmic component
I6K37_RS21140	COG2105	PFAM AIG2 family protein
I6K37_RS21145	COG2911	Protein conserved in bacteria
I6K37_RS21150	COG0729	surface antigen
I6K37_RS21160	COG1253	flavin adenine dinucleotide binding
I6K37_RS21185	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K37_RS21200	COG1733	regulation of RNA biosynthetic process
I6K37_RS21205	COG0702	epimerase
I6K37_RS21215	COG0697	spore germination
I6K37_RS21225	COG1113	amino acid transport
I6K37_RS21230	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K37_RS21235	COG3061	Opacity-associated protein A
I6K37_RS21245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K37_RS21250	COG2965	DNA replication, synthesis of RNA primer
I6K37_RS21310	COG1073	alpha beta
I6K37_RS21315	COG3650	response to hydrogen peroxide
I6K37_RS21325	COG1960	acyl-CoA dehydrogenase activity
I6K37_RS21330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K37_RS21335	COG0557	exoribonuclease II activity
I6K37_RS21350	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K37_RS21360	COG0330	HflC and HflK could
I6K37_RS21365	COG0330	HflC and HflK could
I6K37_RS21370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K37_RS21390	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K37_RS21395	COG0802	atpase or kinase
I6K37_RS21400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K37_RS21400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K37_RS21405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K37_RS21425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS21445	COG3264	Mechanosensitive ion channel
I6K37_RS21445	COG1511	domain protein
I6K37_RS21460	COG1053	succinate dehydrogenase
I6K37_RS21465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K37_RS21485	COG2076	Multidrug Resistance protein
I6K37_RS21490	COG5510	response to toxic substance
I6K37_RS21505	COG1509	lysine 2,3-aminomutase activity
I6K37_RS21570	COG0531	amino acid
I6K37_RS21575	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K37_RS21580	COG1027	Aspartate ammonia-lyase
I6K37_RS21585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K37_RS21600	COG1309	transcriptional regulator
I6K37_RS21630	COG0457	Tetratricopeptide repeat
I6K37_RS21635	COG1649	PFAM Uncharacterised BCR, COG1649
I6K37_RS21635	COG0726	polysaccharide deacetylase
I6K37_RS21640	COG1215	transferase activity, transferring glycosyl groups
I6K37_RS21655	COG0861	Integral membrane protein TerC family
I6K37_RS21695	COG1486	melibiose metabolic process
I6K37_RS21700	COG2169	Transcriptional regulator
I6K37_RS21710	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K37_RS21715	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K37_RS21720	COG2188	Transcriptional regulator
I6K37_RS21725	COG3624	Phosphonate C-P lyase system protein PhnG
I6K37_RS21730	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K37_RS21735	COG3626	phosphonate metabolism
I6K37_RS21740	COG3627	carbon phosphorus lyase activity
I6K37_RS21745	COG4107	phosphonate C-P lyase system protein PhnK
I6K37_RS21750	COG4778	phosphonate C-P lyase system protein PhnL
I6K37_RS21755	COG3454	Phosphonate metabolism
I6K37_RS21765	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K37_RS21775	COG0784	Response regulator, receiver
I6K37_RS21775	COG4191	Histidine kinase
I6K37_RS21780	COG1129	ABC transporter
I6K37_RS21785	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS21820	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K37_RS21825	COG1301	dicarboxylic acid transport
I6K37_RS21835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K37_RS21840	COG3162	membrane
I6K37_RS21870	COG3539	Fimbrial protein
I6K37_RS21875	COG1346	cytolysis
I6K37_RS21880	COG1380	Effector of murein hydrolase LrgA
I6K37_RS21885	COG0583	DNA-binding transcription factor activity
I6K37_RS21890	COG0025	NhaP-type Na H and K H
I6K37_RS21895	COG2252	PERMEase
I6K37_RS21900	COG0625	glutathione transferase activity
I6K37_RS21905	COG0789	Transcriptional regulator
I6K37_RS21915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K37_RS21945	COG1234	tRNA 3'-trailer cleavage
I6K37_RS21950	COG1609	Transcriptional regulator
I6K37_RS21955	COG0483	inositol monophosphate 1-phosphatase activity
I6K37_RS21965	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K37_RS21985	COG4771	TonB-dependent receptor
I6K37_RS21990	COG0741	lytic transglycosylase activity
I6K37_RS22005	COG2315	Protein conserved in bacteria
I6K37_RS22010	COG0432	Pfam Uncharacterised protein family UPF0047
I6K37_RS22025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K37_RS22030	COG0305	Participates in initiation and elongation during chromosome replication
I6K37_RS22045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K37_RS22055	COG0735	belongs to the Fur family
I6K37_RS22060	COG3237	CsbD-like
I6K37_RS22070	COG0534	Mate efflux family protein
I6K37_RS22080	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K37_RS22150	COG0251	oxidation-reduction process
I6K37_RS22160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K37_RS22170	COG0527	aspartate kinase activity
I6K37_RS22220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K37_RS22230	COG0456	acetyltransferase
I6K37_RS22260	COG0151	Belongs to the GarS family
I6K37_RS22270	COG4191	Histidine kinase
I6K37_RS22275	COG3678	ATP-independent chaperone mediated protein folding
I6K37_RS22310	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K37_RS22325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K37_RS22330	COG2104	thiamine diphosphate biosynthetic process
I6K37_RS22345	COG3706	GGDEF domain
I6K37_RS22355	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K37_RS22360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K37_RS22395	COG0250	Participates in transcription elongation, termination and antitermination
I6K37_RS22440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K37_RS22470	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K37_RS22480	COG1739	Uncharacterized protein family UPF0029
I6K37_RS22520	COG0805	protein transport
I6K37_RS22540	COG3165	ubiquinone biosynthetic process from chorismate
I6K37_RS22570	COG0583	DNA-binding transcription factor activity
I6K37_RS22575	COG0697	spore germination
I6K37_RS22580	COG0561	phosphatase activity
I6K37_RS22585	COG2267	carboxylic ester hydrolase activity
I6K37_RS22590	COG1280	lysine exporter protein (LysE YggA)
I6K37_RS22600	COG1280	lysine exporter protein (LysE YggA)
I6K37_RS22630	COG0210	DNA helicase
I6K37_RS22635	COG1011	Hydrolase
I6K37_RS22665	COG3072	Adenylate cyclase
I6K37_RS22680	COG2959	enzyme of heme biosynthesis
I6K37_RS22685	COG3071	HemY protein
I6K37_RS22730	COG2244	polysaccharide biosynthetic process
I6K37_RS22735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K37_RS22740	COG0456	acetyltransferase
I6K37_RS22745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K37_RS22750	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K37_RS22755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K37_RS22760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K37_RS22770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K37_RS22775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K37_RS22780	COG3118	belongs to the thioredoxin family
I6K37_RS22805	COG1811	Na channel or pump
I6K37_RS22815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K37_RS22820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K37_RS22830	COG0583	DNA-binding transcription factor activity
I6K37_RS22835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K37_RS22850	COG3978	acetolactate synthase activity
I6K37_RS22875	COG3085	chromosome segregation
I6K37_RS22950	COG0583	DNA-binding transcription factor activity
I6K37_RS22965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K37_RS22980	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K37_RS22985	COG2207	Transcriptional regulator
I6K37_RS22995	COG0371	Dehydrogenase
I6K37_RS23000	COG0697	spore germination
I6K37_RS23010	COG0583	DNA-binding transcription factor activity
I6K37_RS23020	COG0737	Belongs to the 5'-nucleotidase family
I6K37_RS23030	COG0460	homoserine dehydrogenase
I6K37_RS23030	COG0527	aspartate kinase activity
I6K37_RS23035	COG0626	cystathionine gamma-synthase activity
I6K37_RS23050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K37_RS23055	COG1609	Transcriptional regulator
I6K37_RS23060	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K37_RS23075	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K37_RS23095	COG3678	ATP-independent chaperone mediated protein folding
I6K37_RS23100	COG0745	RESPONSE REGULATOR receiver
I6K37_RS23105	COG2205	protein histidine kinase activity
I6K37_RS23110	COG2258	MOSC domain
I6K37_RS23115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K37_RS23155	COG1129	ABC transporter
I6K37_RS23160	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS23165	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS23170	COG1454	alcohol dehydrogenase
I6K37_RS23180	COG2211	Major facilitator Superfamily
I6K37_RS23225	COG0437	4 iron, 4 sulfur cluster binding
I6K37_RS23230	COG2864	formate dehydrogenase
I6K37_RS23245	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K37_RS23255	COG0456	acetyltransferase
I6K37_RS23270	COG1011	Hydrolase
I6K37_RS23285	COG3852	Histidine kinase
I6K37_RS23300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K37_RS23320	COG0204	Acyl-transferase
I6K37_RS23330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K37_RS23335	COG3084	Protein conserved in bacteria
I6K37_RS23345	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K37_RS23370	COG2186	Transcriptional regulator
I6K37_RS23375	COG0477	Major facilitator Superfamily
I6K37_RS23380	COG1609	Transcriptional regulator
I6K37_RS23385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K37_RS23395	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS23400	COG1129	ABC transporter
I6K37_RS23430	COG1522	sequence-specific DNA binding
I6K37_RS23435	COG0716	FMN binding
I6K37_RS23450	COG3312	ion transport
I6K37_RS23500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K37_RS23505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K37_RS23510	COG0573	inorganic phosphate transmembrane transporter activity
I6K37_RS23515	COG0581	inorganic phosphate transmembrane transporter activity
I6K37_RS23520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K37_RS23525	COG0704	Plays a role in the regulation of phosphate uptake
I6K37_RS23535	COG2382	esterase
I6K37_RS23540	COG0363	glucosamine-6-phosphate deaminase activity
I6K37_RS23545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K37_RS23550	COG2252	PERMEase
I6K37_RS23555	COG0431	NADPH-dependent FMN reductase
I6K37_RS23560	COG2091	lysine biosynthetic process via aminoadipic acid
I6K37_RS23590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K37_RS23620	COG0187	DNA topoisomerase II activity
I6K37_RS23625	COG0561	phosphatase activity
I6K37_RS23640	COG2186	Transcriptional regulator
I6K37_RS23645	COG3734	2-keto-3-deoxy-galactonokinase
I6K37_RS23650	COG0800	Aldolase
I6K37_RS23660	COG2271	Major facilitator Superfamily
I6K37_RS23665	COG0823	Involved in the tonB-independent uptake of proteins
I6K37_RS23670	COG5645	(Lipo)protein
I6K37_RS23685	COG3645	SOS response
I6K37_RS23695	COG2188	Transcriptional regulator
I6K37_RS23710	COG2149	membrane
I6K37_RS23730	COG2610	gluconate transmembrane transporter activity
I6K37_RS23740	COG0583	DNA-binding transcription factor activity
I6K37_RS23745	COG2814	Major facilitator Superfamily
I6K37_RS23775	COG0028	Belongs to the TPP enzyme family
I6K37_RS23780	COG0440	acetolactate synthase activity
I6K37_RS23785	COG2197	response regulator
I6K37_RS23795	COG2271	Major facilitator Superfamily
I6K37_RS23835	COG2188	Transcriptional regulator
I6K37_RS23860	COG4580	involved in the transport of maltose and maltodextrins
I6K37_RS23865	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K37_RS23870	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS23870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K37_RS23880	COG1609	Transcriptional regulator
I6K37_RS23895	COG0583	DNA-binding transcription factor activity
I6K37_RS23900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K37_RS23905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K37_RS23910	COG2828	Protein conserved in bacteria
I6K37_RS23925	COG0697	spore germination
I6K37_RS23930	COG1263	PTS System
I6K37_RS23930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K37_RS23940	COG2814	Major facilitator Superfamily
I6K37_RS23950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K37_RS23985	COG0583	DNA-binding transcription factor activity
I6K37_RS24010	COG1464	Belongs to the NlpA lipoprotein family
I6K37_RS24025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K37_RS24035	COG1064	alcohol dehydrogenase
I6K37_RS24065	COG2211	Major facilitator Superfamily
I6K37_RS24070	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K37_RS24080	COG1486	melibiose metabolic process
I6K37_RS24085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K37_RS24085	COG1263	PTS System
I6K37_RS24090	COG2982	Protein involved in outer membrane biogenesis
I6K37_RS24095	COG2233	PERMEase
I6K37_RS24100	COG0786	glutamate:sodium symporter activity
I6K37_RS24120	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K37_RS24145	COG3152	Membrane
I6K37_RS24155	COG1494	fructose-1,6-bisphosphatase
I6K37_RS24160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K37_RS24165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K37_RS24170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K37_RS24190	COG2860	membrane
I6K37_RS24200	COG2169	Transcriptional regulator
I6K37_RS24200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K37_RS24205	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K37_RS24210	COG1561	YicC-like family, N-terminal region
I6K37_RS24230	COG1131	(ABC) transporter
I6K37_RS24235	COG0842	Transport permease protein
I6K37_RS24265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K37_RS24300	COG1519	Transferase
I6K37_RS24305	COG1216	Glycosyl transferase, family 2
I6K37_RS24310	COG0438	transferase activity, transferring glycosyl groups
I6K37_RS24320	COG0859	PFAM glycosyl transferase family 9
I6K37_RS24345	COG0859	PFAM glycosyl transferase family 9
I6K37_RS24360	COG0156	8-amino-7-oxononanoate synthase activity
I6K37_RS24370	COG0463	Glycosyl transferase, family 2
I6K37_RS24375	COG2861	carbohydrate metabolic process
I6K37_RS24380	COG4942	peptidase
I6K37_RS24390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K37_RS24395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K37_RS24415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K37_RS24425	COG2186	Transcriptional regulator
I6K37_RS24445	COG3722	fumarate hydratase activity
I6K37_RS24465	COG0625	glutathione transferase activity
I6K37_RS24475	COG3276	selenocysteine insertion sequence binding
I6K37_RS24480	COG1414	Transcriptional regulator
I6K37_RS24485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K37_RS24490	COG3977	Valine--pyruvate aminotransferase
I6K37_RS24495	COG0366	Alpha amylase catalytic
I6K37_RS24500	COG2992	FlgJ-related protein
I6K37_RS24505	COG1609	Transcriptional regulator
I6K37_RS24505	COG2207	Transcriptional regulator
I6K37_RS24510	COG4214	carbohydrate transport
I6K37_RS24520	COG4213	ABC transporter substrate-binding protein
I6K37_RS24535	COG4682	membrane
I6K37_RS24540	COG4682	membrane
I6K37_RS24545	COG3274	enterobacterial common antigen metabolic process
I6K37_RS24575	COG1278	Cold shock
I6K37_RS24580	COG2944	sequence-specific DNA binding
I6K37_RS24585	COG2814	Major facilitator Superfamily
I6K37_RS24605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K37_RS24615	COG1609	Transcriptional regulator
I6K37_RS24620	COG2885	chlorophyll binding
I6K37_RS24625	COG0243	molybdopterin cofactor binding
I6K37_RS24630	COG0456	acetyltransferase
I6K37_RS24635	COG2818	Glycosylase
I6K37_RS24640	COG5571	outer membrane autotransporter
I6K37_RS24645	COG2223	nitrite transmembrane transporter activity
I6K37_RS24670	COG0747	negative chemotaxis
I6K37_RS24675	COG0601	transmembrane transport
I6K37_RS24680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS24685	COG0444	Belongs to the ABC transporter superfamily
I6K37_RS24690	COG4608	Belongs to the ABC transporter superfamily
I6K37_RS24705	COG2894	cell division
I6K37_RS24715	COG1215	transferase activity, transferring glycosyl groups
I6K37_RS24720	COG0457	Tetratricopeptide repeat
I6K37_RS24735	COG2194	sulfuric ester hydrolase activity
I6K37_RS24765	COG1215	transferase activity, transferring glycosyl groups
I6K37_RS24770	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K37_RS24775	COG3118	belongs to the thioredoxin family
I6K37_RS24775	COG0457	Tetratricopeptide repeat
I6K37_RS24780	COG2200	EAL domain
I6K37_RS24780	COG2199	diguanylate cyclase activity
I6K37_RS24790	COG0612	Peptidase, M16
I6K37_RS24805	COG0477	Major facilitator Superfamily
I6K37_RS24810	COG1295	ribonuclease BN
I6K37_RS24815	COG0583	DNA-binding transcription factor activity
I6K37_RS24820	COG1028	Short-chain dehydrogenase reductase Sdr
I6K37_RS24825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K37_RS24835	COG1454	alcohol dehydrogenase
I6K37_RS24845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K37_RS24850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K37_RS24855	COG0671	phosphoesterase, PA-phosphatase related
I6K37_RS24875	COG0589	response to stress
I6K37_RS24885	COG0306	phosphate transporter
I6K37_RS24890	COG2081	HI0933 family
I6K37_RS24895	COG2239	Acts as a magnesium transporter
I6K37_RS24910	COG1124	(ABC) transporter
I6K37_RS24920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS24925	COG0601	transmembrane transport
I6K37_RS24930	COG0747	negative chemotaxis
I6K37_RS24940	COG3479	Phenolic acid decarboxylase
I6K37_RS24980	COG0628	permease
I6K37_RS24985	COG0477	Major facilitator Superfamily
I6K37_RS24995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K37_RS25010	COG3714	YhhN family
I6K37_RS25020	COG3776	membrane
I6K37_RS25025	COG0742	ribosomal rna small subunit methyltransferase
I6K37_RS25030	COG0552	protein localization to endoplasmic reticulum
I6K37_RS25035	COG2884	Cell division ATP-binding protein ftsE
I6K37_RS25040	COG2177	Part of the ABC transporter FtsEX involved in
I6K37_RS25055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K37_RS25065	COG0683	leucine binding
I6K37_RS25075	COG0683	leucine binding
I6K37_RS25080	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K37_RS25130	COG0584	glycerophosphoryl diester phosphodiesterase
I6K37_RS25140	COG0405	Gamma-glutamyltransferase
I6K37_RS25145	COG1247	-acetyltransferase
I6K37_RS25155	COG0673	inositol 2-dehydrogenase activity
I6K37_RS25160	COG1741	Belongs to the pirin family
I6K37_RS25165	COG1609	Transcriptional regulator
I6K37_RS25170	COG3265	gluconokinase activity
I6K37_RS25175	COG2610	gluconate transmembrane transporter activity
I6K37_RS25185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K37_RS25210	COG0058	SHG alpha-glucan phosphorylase activity
I6K37_RS25215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K37_RS25230	COG1349	DNA-binding transcription factor activity
I6K37_RS25240	COG0058	SHG alpha-glucan phosphorylase activity
I6K37_RS25245	COG1640	4-alpha-glucanotransferase
I6K37_RS25250	COG2610	gluconate transmembrane transporter activity
I6K37_RS25260	COG1040	competence protein
I6K37_RS25285	COG1918	ferrous iron import across plasma membrane
I6K37_RS25290	COG2183	response to ionizing radiation
I6K37_RS25295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K37_RS25320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K37_RS25325	COG1011	Hydrolase
I6K37_RS25335	COG0494	nUDIX hydrolase
I6K37_RS25340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K37_RS25365	COG4796	Type ii and iii secretion system protein
I6K37_RS25380	COG3266	domain, Protein
I6K37_RS25385	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K37_RS25390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K37_RS25415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K37_RS25425	COG0738	Major facilitator superfamily
I6K37_RS25450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K37_RS25455	COG1289	transmembrane transporter activity
I6K37_RS25465	COG1765	OsmC-like protein
I6K37_RS25470	COG3954	Phosphoribulokinase
I6K37_RS25480	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K37_RS25485	COG0488	(ABC) transporter
I6K37_RS25500	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K37_RS25505	COG1047	Peptidyl-prolyl cis-trans
I6K37_RS25515	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K37_RS25520	COG2964	Protein conserved in bacteria
I6K37_RS25575	COG0051	transcription antitermination factor activity, RNA binding
I6K37_RS25600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K37_RS25615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K37_RS25680	COG0201	protein transport
I6K37_RS25705	COG0202	RNA polymerase activity
I6K37_RS25720	COG0789	Transcriptional regulator
I6K37_RS25725	COG3036	rescue of stalled ribosome
I6K37_RS25755	COG0758	DNA mediated transformation
I6K37_RS25765	COG0551	DNA topoisomerase type I activity
I6K37_RS25785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K37_RS25820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K37_RS25825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS25830	COG1309	transcriptional regulator
I6K37_RS25850	COG4145	pantothenate transmembrane transporter activity
I6K37_RS25855	COG3924	membrane
I6K37_RS25885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K37_RS25965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K37_RS25985	COG2274	protein secretion by the type I secretion system
I6K37_RS25985	COG3271	cysteine-type peptidase activity
I6K37_RS25995	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I6K37_RS26015	COG3451	type IV secretory pathway VirB4
I6K37_RS26055	COG2026	Addiction module toxin, RelE StbE family
I6K37_RS26115	COG0330	HflC and HflK could
I6K37_RS26515	COG2026	Addiction module toxin, RelE StbE family
I6K37_RS26520	COG3077	Addiction module antitoxin, RelB DinJ family
I6K37_RS26525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6K37_RS26535	COG3547	Transposase (IS116 IS110 IS902 family)
I6K37_RS26570	COG1475	DNA binding
I6K37_RS26625	COG3344	reverse transcriptase
I6K37_RS26685	COG2199	diguanylate cyclase activity
I6K37_RS26685	COG2203	Gaf domain
I6K37_RS26690	COG5001	Diguanylate cyclase
I6K37_RS26690	COG1716	ATPase activity
I6K37_RS26705	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K37_RS26720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K37_RS26765	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K37_RS26795	COG0739	heme binding
I6K37_RS26805	COG2132	Multicopper oxidase
I6K37_RS26810	COG3667	copper resistance
I6K37_RS26815	COG2372	response to copper ion
I6K37_RS26820	COG1276	copper resistance
I6K37_RS26825	COG0745	RESPONSE REGULATOR receiver
I6K37_RS26830	COG2205	protein histidine kinase activity
I6K37_RS26850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K37_RS26865	COG0431	NADPH-dependent FMN reductase
I6K37_RS26895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K37_RS26960	COG2801	Transposase and inactivated derivatives
I6K37_RS26970	COG0501	Belongs to the peptidase M48B family
I6K37_RS26985	COG0542	response to heat
I6K37_RS26990	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K37_RS27075	COG4172	Belongs to the ABC transporter superfamily
I6K37_RS27090	COG0601	transmembrane transport
I6K37_RS27095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K37_RS27120	COG1595	DNA-templated transcription, initiation
I6K37_RS27125	COG3712	iron ion homeostasis
I6K37_RS27130	COG4772	TonB-dependent receptor
I6K37_RS27135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K37_RS27140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS27145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K37_RS27150	COG1120	ATPase activity
I6K37_RS27155	COG3436	PFAM IS66 Orf2 family protein
I6K37_RS27175	COG1609	Transcriptional regulator
I6K37_RS27185	COG2223	nitrite transmembrane transporter activity
I6K37_RS27240	COG1126	abc transporter atp-binding protein
I6K37_RS27245	COG0765	amino acid transport
I6K37_RS27250	COG0765	amino acid transport
I6K37_RS27255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K37_RS27280	COG1609	Transcriptional regulator
I6K37_RS27285	COG2222	sugar isomerase
I6K37_RS27290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K37_RS27300	COG0765	amino acid transport
I6K37_RS27320	COG2801	Transposase and inactivated derivatives
I6K37_RS27325	COG3547	Transposase (IS116 IS110 IS902 family)
I6K37_RS27415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6K37_RS27425	COG0589	response to stress
I6K37_RS27430	COG0659	secondary active sulfate transmembrane transporter activity
I6K37_RS27440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K37_RS27445	COG1393	Belongs to the ArsC family
I6K37_RS27450	COG0431	NADPH-dependent FMN reductase
I6K37_RS27485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K37_RS27565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K37_RS27585	COG3271	cysteine-type peptidase activity
I6K37_RS27585	COG2274	protein secretion by the type I secretion system
I6K37_RS27595	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis