locus-tag	class	description
I6K38_RS00055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K38_RS00095	COG3039	Transposase
I6K38_RS00105	COG3344	reverse transcriptase
I6K38_RS00125	COG1192	Involved in chromosome partitioning
I6K38_RS00170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K38_RS00175	COG1902	pentaerythritol trinitrate reductase activity
I6K38_RS00180	COG3118	belongs to the thioredoxin family
I6K38_RS00185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K38_RS00270	COG1983	PspC domain protein
I6K38_RS00280	COG1842	Phage shock protein A
I6K38_RS00305	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS00315	COG2233	PERMEase
I6K38_RS00330	COG1393	Belongs to the ArsC family
I6K38_RS00335	COG4783	chaperone-mediated protein folding
I6K38_RS00345	COG0628	permease
I6K38_RS00350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K38_RS00355	COG2716	regulation of RNA biosynthetic process
I6K38_RS00365	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K38_RS00375	COG2321	neutral zinc metallopeptidase
I6K38_RS00380	COG1444	tRNA N-acetyltransferase activity
I6K38_RS00385	COG0400	carboxylic ester hydrolase activity
I6K38_RS00400	COG1393	Belongs to the ArsC family
I6K38_RS00410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K38_RS00415	COG0493	'glutamate synthase
I6K38_RS00415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K38_RS00425	COG5342	invasion associated locus B
I6K38_RS00430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K38_RS00435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K38_RS00445	COG4810	utilization protein
I6K38_RS00535	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K38_RS00555	COG2837	iron assimilation
I6K38_RS00565	COG4150	thiosulfate binding
I6K38_RS00570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K38_RS00575	COG4208	sulfate ABC transporter
I6K38_RS00580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K38_RS00590	COG4319	ketosteroid isomerase
I6K38_RS00625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K38_RS00645	COG3530	Putative quorum-sensing-regulated virulence factor
I6K38_RS00650	COG0385	Bile acid
I6K38_RS00655	COG0583	DNA-binding transcription factor activity
I6K38_RS00685	COG3415	Transposase
I6K38_RS00690	COG3415	Transposase
I6K38_RS00705	COG2199	diguanylate cyclase activity
I6K38_RS00705	COG2200	EAL domain
I6K38_RS00710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K38_RS00725	COG0667	Aldo Keto reductase
I6K38_RS00730	COG3961	Belongs to the TPP enzyme family
I6K38_RS00745	COG3279	Response regulator of the LytR AlgR family
I6K38_RS00750	COG3275	phosphorelay sensor kinase activity
I6K38_RS00765	COG0436	Aminotransferase
I6K38_RS00775	COG2807	transmembrane transport
I6K38_RS00780	COG0590	tRNA wobble adenosine to inosine editing
I6K38_RS00785	COG0583	DNA-binding transcription factor activity
I6K38_RS00840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K38_RS00845	COG4197	protein conserved in bacteria, prophage-related
I6K38_RS00900	COG3179	chitinase
I6K38_RS00945	COG0740	serine-type endopeptidase activity
I6K38_RS00985	COG1196	nuclear chromosome segregation
I6K38_RS01035	COG2116	formate transmembrane transporter activity
I6K38_RS01040	COG2853	Lipoprotein
I6K38_RS01050	COG3691	Protein conserved in bacteria
I6K38_RS01065	COG2062	phosphohistidine phosphatase, SixA
I6K38_RS01090	COG0730	response to heat
I6K38_RS01095	COG3101	peptidyl-lysine hydroxylation
I6K38_RS01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K38_RS01130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K38_RS01140	COG0586	Pfam SNARE associated Golgi protein
I6K38_RS01150	COG0285	dihydrofolate synthase activity
I6K38_RS01155	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K38_RS01160	COG1286	toxin biosynthetic process
I6K38_RS01165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K38_RS01170	COG0163	prenyltransferase activity
I6K38_RS01195	COG4160	amino acid transport
I6K38_RS01200	COG4598	ABC transporter
I6K38_RS01215	COG1090	epimerase
I6K38_RS01220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K38_RS01225	COG0625	glutathione transferase activity
I6K38_RS01230	COG0625	glutathione transferase activity
I6K38_RS01240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K38_RS01245	COG0280	phosphate acetyltransferase
I6K38_RS01245	COG0857	belongs to the CobB CobQ family
I6K38_RS01265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K38_RS01270	COG0490	domain, Protein
I6K38_RS01270	COG0471	metal ion transport
I6K38_RS01280	COG0436	Aminotransferase
I6K38_RS01285	COG0583	DNA-binding transcription factor activity
I6K38_RS01330	COG0839	Belongs to the complex I subunit 6 family
I6K38_RS01340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K38_RS01345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K38_RS01360	COG2153	protein acetylation
I6K38_RS01365	COG1169	isochorismate synthase
I6K38_RS01390	COG0318	PFAM AMP-dependent synthetase and ligase
I6K38_RS01400	COG5464	transposase or invertase
I6K38_RS01415	COG1414	Transcriptional regulator
I6K38_RS01425	COG2271	Major facilitator Superfamily
I6K38_RS01435	COG0247	lactate metabolic process
I6K38_RS01445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K38_RS01450	COG2271	Major facilitator Superfamily
I6K38_RS01460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K38_RS01485	COG2205	protein histidine kinase activity
I6K38_RS01485	COG0784	Response regulator, receiver
I6K38_RS01495	COG2198	Histidine kinase
I6K38_RS01495	COG0642	Histidine kinase
I6K38_RS01510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K38_RS01510	COG2169	Transcriptional regulator
I6K38_RS01515	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K38_RS01520	COG4615	Cyclic peptide transporter
I6K38_RS01525	COG2239	Acts as a magnesium transporter
I6K38_RS01530	COG0659	secondary active sulfate transmembrane transporter activity
I6K38_RS01545	COG0628	permease
I6K38_RS01570	COG1349	DNA-binding transcription factor activity
I6K38_RS01575	COG0494	nUDIX hydrolase
I6K38_RS01595	COG1061	Type III restriction enzyme res subunit
I6K38_RS01600	COG1187	pseudouridine synthase activity
I6K38_RS01605	COG2814	Major facilitator Superfamily
I6K38_RS01615	COG4172	Belongs to the ABC transporter superfamily
I6K38_RS01620	COG4239	(ABC) transporter, permease
I6K38_RS01625	COG4174	ABC transporter (Permease)
I6K38_RS01630	COG4166	transmembrane transport
I6K38_RS01635	COG2200	EAL domain
I6K38_RS01640	COG0791	NLP P60 protein
I6K38_RS01645	COG0671	phosphoesterase, PA-phosphatase related
I6K38_RS01650	COG0523	cobalamin synthesis protein
I6K38_RS01655	COG0246	Mannitol dehydrogenase
I6K38_RS01660	COG1312	Catalyzes the dehydration of D-mannonate
I6K38_RS01680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS01680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS01685	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K38_RS01690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS01690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS01690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K38_RS01700	COG2855	membrane
I6K38_RS01705	COG0583	DNA-binding transcription factor activity
I6K38_RS01710	COG0833	amino acid
I6K38_RS01715	COG4771	TonB-dependent receptor
I6K38_RS01730	COG2311	Membrane
I6K38_RS01745	COG1129	ABC transporter
I6K38_RS01755	COG2949	membrane
I6K38_RS01765	COG1346	cytolysis
I6K38_RS01775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K38_RS01780	COG3659	wide pore channel activity
I6K38_RS01795	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS01805	COG1538	Outer membrane efflux protein
I6K38_RS01810	COG0586	Pfam SNARE associated Golgi protein
I6K38_RS01820	COG1686	Belongs to the peptidase S11 family
I6K38_RS01830	COG0277	FAD linked oxidase domain protein
I6K38_RS01835	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K38_RS01840	COG1732	Glycine betaine
I6K38_RS01845	COG1174	glycine betaine transport
I6K38_RS01850	COG1125	glycine betaine transport
I6K38_RS01855	COG1174	glycine betaine transport
I6K38_RS01865	COG3275	phosphorelay sensor kinase activity
I6K38_RS01875	COG4807	Protein conserved in bacteria
I6K38_RS01895	COG5455	response to cobalt ion
I6K38_RS01900	COG0583	DNA-binding transcription factor activity
I6K38_RS01905	COG2252	PERMEase
I6K38_RS01915	COG0583	DNA-binding transcription factor activity
I6K38_RS01930	COG0351	phosphomethylpyrimidine kinase
I6K38_RS01935	COG1830	Aldolase
I6K38_RS01970	COG1070	Carbohydrate kinase
I6K38_RS01980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K38_RS01985	COG4948	Mandelate Racemase Muconate Lactonizing
I6K38_RS01990	COG0747	negative chemotaxis
I6K38_RS01995	COG0601	transmembrane transport
I6K38_RS02000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS02005	COG0444	Belongs to the ABC transporter superfamily
I6K38_RS02010	COG4608	Belongs to the ABC transporter superfamily
I6K38_RS02020	COG0826	peptidase U32
I6K38_RS02025	COG0745	RESPONSE REGULATOR receiver
I6K38_RS02030	COG2205	protein histidine kinase activity
I6K38_RS02055	COG1301	dicarboxylic acid transport
I6K38_RS02075	COG5002	protein histidine kinase activity
I6K38_RS02080	COG0443	Heat shock 70 kDa protein
I6K38_RS02085	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K38_RS02100	COG2982	Protein involved in outer membrane biogenesis
I6K38_RS02105	COG1253	flavin adenine dinucleotide binding
I6K38_RS02240	COG0438	transferase activity, transferring glycosyl groups
I6K38_RS02245	COG1215	transferase activity, transferring glycosyl groups
I6K38_RS02265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K38_RS02295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K38_RS02300	COG0583	DNA-binding transcription factor activity
I6K38_RS02310	COG0531	amino acid
I6K38_RS02315	COG0640	Transcriptional regulator
I6K38_RS02320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K38_RS02325	COG2925	Exonuclease
I6K38_RS02340	COG1289	transmembrane transporter activity
I6K38_RS02360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K38_RS02370	COG1942	4-Oxalocrotonate Tautomerase
I6K38_RS02375	COG0583	DNA-binding transcription factor activity
I6K38_RS02380	COG0095	Lipoate-protein ligase
I6K38_RS02385	COG0477	Major facilitator Superfamily
I6K38_RS02395	COG5001	Diguanylate cyclase
I6K38_RS02395	COG3300	MHYT domain
I6K38_RS02400	COG3615	Tellurite resistance protein tehB
I6K38_RS02425	COG3706	GGDEF domain
I6K38_RS02440	COG0534	Mate efflux family protein
I6K38_RS02450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K38_RS02470	COG0604	alcohol dehydrogenase
I6K38_RS02475	COG1309	transcriptional regulator
I6K38_RS02480	COG0025	NhaP-type Na H and K H
I6K38_RS02530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K38_RS02540	COG1418	mRNA catabolic process
I6K38_RS02545	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K38_RS02550	COG3727	T/G mismatch-specific endonuclease activity
I6K38_RS02555	COG0697	spore germination
I6K38_RS02560	COG2354	Protein conserved in bacteria
I6K38_RS02590	COG0366	Alpha amylase catalytic
I6K38_RS02595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS02605	COG0765	amino acid transport
I6K38_RS02610	COG1126	abc transporter atp-binding protein
I6K38_RS02615	COG2197	response regulator
I6K38_RS02625	COG2197	response regulator
I6K38_RS02660	COG3318	Belongs to the UPF0149 family
I6K38_RS02660	COG3012	SEC-C Motif Domain Protein
I6K38_RS02665	COG0814	amino acid
I6K38_RS02675	COG1528	Iron-storage protein
I6K38_RS02690	COG0477	Major facilitator Superfamily
I6K38_RS02700	COG2211	Major facilitator Superfamily
I6K38_RS02710	COG1528	Iron-storage protein
I6K38_RS02720	COG1879	ABC-type sugar transport system periplasmic component
I6K38_RS02730	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS02755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K38_RS02765	COG3102	Protein conserved in bacteria
I6K38_RS02785	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K38_RS02790	COG1801	Protein of unknown function DUF72
I6K38_RS02795	COG1335	isochorismatase
I6K38_RS02805	COG0494	nUDIX hydrolase
I6K38_RS02830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K38_RS02840	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K38_RS02845	COG0739	heme binding
I6K38_RS02850	COG1560	Kdo2-lipid A biosynthetic process
I6K38_RS02860	COG1737	Transcriptional regulator
I6K38_RS02870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K38_RS02875	COG0129	dihydroxy-acid dehydratase activity
I6K38_RS02880	COG0800	Aldolase
I6K38_RS02890	COG3141	response to X-ray
I6K38_RS02895	COG2979	Protein of unknown function (DUF533)
I6K38_RS02900	COG1770	oligopeptidase
I6K38_RS02905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K38_RS02915	COG2372	response to copper ion
I6K38_RS02920	COG1276	copper resistance
I6K38_RS02935	COG2990	Protein conserved in bacteria
I6K38_RS02960	COG3008	intermembrane lipid transfer
I6K38_RS02965	COG2995	paraquat-inducible protein a
I6K38_RS02970	COG1956	GAF domain-containing protein
I6K38_RS02990	COG2814	Major facilitator Superfamily
I6K38_RS02995	COG1414	Transcriptional regulator
I6K38_RS03025	COG0768	penicillin binding
I6K38_RS03030	COG2226	methyltransferase
I6K38_RS03045	COG3716	PTS system mannose fructose sorbose family IID component
I6K38_RS03050	COG3715	PTS system
I6K38_RS03055	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS03055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K38_RS03060	COG1253	flavin adenine dinucleotide binding
I6K38_RS03065	COG2200	EAL domain
I6K38_RS03070	COG1760	l-serine dehydratase
I6K38_RS03090	COG0251	oxidation-reduction process
I6K38_RS03095	COG1199	ATP-dependent helicase activity
I6K38_RS03105	COG3065	identical protein binding
I6K38_RS03115	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K38_RS03125	COG2894	cell division
I6K38_RS03140	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K38_RS03170	COG2719	SpoVR family
I6K38_RS03195	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K38_RS03205	COG4774	siderophore transport
I6K38_RS03220	COG2308	Evidence 4 Homologs of previously reported genes of
I6K38_RS03265	COG0583	DNA-binding transcription factor activity
I6K38_RS03270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K38_RS03285	COG1882	Formate acetyltransferase
I6K38_RS03320	COG0583	DNA-binding transcription factor activity
I6K38_RS03350	COG0583	DNA-binding transcription factor activity
I6K38_RS03365	COG3122	Protein conserved in bacteria
I6K38_RS03385	COG2885	chlorophyll binding
I6K38_RS03420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K38_RS03500	COG0012	GTP binding
I6K38_RS03520	COG0659	secondary active sulfate transmembrane transporter activity
I6K38_RS03550	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K38_RS03570	COG0387	Pfam Sodium calcium exchanger
I6K38_RS03575	COG4572	Cation transport regulator
I6K38_RS03580	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K38_RS03590	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K38_RS03595	COG3707	response regulator
I6K38_RS03600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K38_RS03610	COG1116	anion transmembrane transporter activity
I6K38_RS03615	COG2146	nitrite reductase [NAD(P)H] activity
I6K38_RS03615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K38_RS03620	COG0243	molybdopterin cofactor binding
I6K38_RS03625	COG4932	domain protein
I6K38_RS03630	COG2197	response regulator
I6K38_RS03635	COG3850	Histidine kinase
I6K38_RS03640	COG2223	nitrite transmembrane transporter activity
I6K38_RS03650	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K38_RS03655	COG1140	nitrate reductase beta subunit
I6K38_RS03660	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K38_RS03665	COG2181	nitrate reductase activity
I6K38_RS03675	COG1522	sequence-specific DNA binding
I6K38_RS03720	COG0788	formyltetrahydrofolate deformylase activity
I6K38_RS03730	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K38_RS03735	COG0745	RESPONSE REGULATOR receiver
I6K38_RS03740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K38_RS03745	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K38_RS03755	COG1435	thymidine kinase activity
I6K38_RS03760	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS03760	COG1454	alcohol dehydrogenase
I6K38_RS03770	COG2095	MarC family integral membrane protein
I6K38_RS03775	COG4166	transmembrane transport
I6K38_RS03780	COG0601	transmembrane transport
I6K38_RS03785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS03790	COG0444	Belongs to the ABC transporter superfamily
I6K38_RS03800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K38_RS03820	COG2353	YceI-like domain
I6K38_RS03830	COG2350	Protein conserved in bacteria
I6K38_RS03840	COG3001	Fructosamine kinase
I6K38_RS03850	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K38_RS03855	COG3137	Salt-induced outer membrane protein
I6K38_RS03895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K38_RS03895	COG0072	phenylalanine-tRNA ligase activity
I6K38_RS03915	COG0583	DNA-binding transcription factor activity
I6K38_RS03935	COG0386	Belongs to the glutathione peroxidase family
I6K38_RS03945	COG0791	NLP P60 protein
I6K38_RS03955	COG4256	Hemin uptake protein
I6K38_RS03960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K38_RS03975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K38_RS03975	COG0574	Belongs to the PEP-utilizing enzyme family
I6K38_RS03985	COG0628	permease
I6K38_RS03990	COG0247	lactate metabolic process
I6K38_RS03990	COG0277	FAD linked oxidase domain protein
I6K38_RS03995	COG2050	protein possibly involved in aromatic compounds catabolism
I6K38_RS04000	COG2261	transglycosylase associated protein
I6K38_RS04025	COG1120	ATPase activity
I6K38_RS04030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS04040	COG0583	DNA-binding transcription factor activity
I6K38_RS04065	COG1304	FMN binding
I6K38_RS04070	COG1309	transcriptional regulator
I6K38_RS04090	COG0316	Belongs to the HesB IscA family
I6K38_RS04095	COG0719	Fe-S assembly protein
I6K38_RS04100	COG0396	ATPase activity
I6K38_RS04105	COG0719	Fe-S assembly protein
I6K38_RS04120	COG1376	ErfK ybiS ycfS ynhG family protein
I6K38_RS04150	COG1309	transcriptional regulator
I6K38_RS04155	COG1082	Xylose isomerase domain protein TIM barrel
I6K38_RS04155	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K38_RS04160	COG2271	Major facilitator Superfamily
I6K38_RS04165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K38_RS04175	COG1120	ATPase activity
I6K38_RS04180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS04185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K38_RS04190	COG1414	Transcriptional regulator
I6K38_RS04225	COG2814	Major facilitator Superfamily
I6K38_RS04245	COG0583	DNA-binding transcription factor activity
I6K38_RS04250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K38_RS04270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K38_RS04275	COG1116	anion transmembrane transporter activity
I6K38_RS04280	COG4774	siderophore transport
I6K38_RS04285	COG1120	ATPase activity
I6K38_RS04290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS04295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS04315	COG0765	amino acid transport
I6K38_RS04320	COG1126	abc transporter atp-binding protein
I6K38_RS04360	COG3383	formate dehydrogenase (NAD+) activity
I6K38_RS04365	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K38_RS04375	COG1175	transmembrane transport
I6K38_RS04405	COG1857	crispr-associated protein
I6K38_RS04415	COG1518	maintenance of DNA repeat elements
I6K38_RS04420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K38_RS04425	COG3157	Type VI secretion system effector, Hcp
I6K38_RS04455	COG4133	protoheme IX ABC transporter activity
I6K38_RS04460	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K38_RS04465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K38_RS04480	COG1138	Cytochrome C-type biogenesis protein
I6K38_RS04485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K38_RS04490	COG3088	subunit of a heme lyase
I6K38_RS04490	COG4235	cytochrome complex assembly
I6K38_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS04535	COG2610	gluconate transmembrane transporter activity
I6K38_RS04540	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K38_RS04550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K38_RS04560	COG0583	DNA-binding transcription factor activity
I6K38_RS04580	COG0277	FAD linked oxidase domain protein
I6K38_RS04585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K38_RS04610	COG0402	S-adenosylhomocysteine deaminase activity
I6K38_RS04650	COG2200	EAL domain
I6K38_RS04665	COG2205	protein histidine kinase activity
I6K38_RS04670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS04690	COG2200	EAL domain
I6K38_RS04730	COG2814	Major facilitator Superfamily
I6K38_RS04735	COG1082	Xylose isomerase domain protein TIM barrel
I6K38_RS04745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K38_RS04775	COG4608	Belongs to the ABC transporter superfamily
I6K38_RS04780	COG0444	Belongs to the ABC transporter superfamily
I6K38_RS04805	COG0346	lactoylglutathione lyase activity
I6K38_RS04810	COG1349	DNA-binding transcription factor activity
I6K38_RS04845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K38_RS04865	COG0300	oxidoreductase activity
I6K38_RS04905	COG0307	riboflavin synthase, alpha
I6K38_RS04910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K38_RS04915	COG2814	Major facilitator Superfamily
I6K38_RS04920	COG0583	DNA-binding transcription factor activity
I6K38_RS04935	COG2814	Major facilitator Superfamily
I6K38_RS04950	COG0791	NLP P60 protein
I6K38_RS04955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K38_RS04965	COG0346	lactoylglutathione lyase activity
I6K38_RS04970	COG1902	pentaerythritol trinitrate reductase activity
I6K38_RS04975	COG1309	transcriptional regulator
I6K38_RS04980	COG3313	Fe-S protein
I6K38_RS04985	COG4989	oxidoreductase activity
I6K38_RS04990	COG2032	superoxide dismutase activity
I6K38_RS04995	COG1289	transmembrane transporter activity
I6K38_RS05000	COG1566	PFAM secretion protein HlyD family protein
I6K38_RS05015	COG3706	GGDEF domain
I6K38_RS05030	COG3895	Periplasmic Protein
I6K38_RS05045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K38_RS05050	COG0625	glutathione transferase activity
I6K38_RS05060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K38_RS05070	COG4659	FMN binding
I6K38_RS05105	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS05115	COG0673	inositol 2-dehydrogenase activity
I6K38_RS05125	COG2814	Major facilitator Superfamily
I6K38_RS05145	COG3038	cytochrome b561
I6K38_RS05165	COG0583	DNA-binding transcription factor activity
I6K38_RS05170	COG3485	protocatechuate 3,4-dioxygenase
I6K38_RS05175	COG3485	protocatechuate 3,4-dioxygenase
I6K38_RS05180	COG5383	Protein conserved in bacteria
I6K38_RS05185	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K38_RS05200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K38_RS05205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K38_RS05210	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K38_RS05215	COG0500	methyltransferase
I6K38_RS05225	COG0697	spore germination
I6K38_RS05230	COG2207	Transcriptional regulator
I6K38_RS05230	COG3708	Transcriptional regulator
I6K38_RS05235	COG3135	benzoate transporter
I6K38_RS05240	COG1396	sequence-specific DNA binding
I6K38_RS05250	COG0826	peptidase U32
I6K38_RS05270	COG1294	oxidase, subunit
I6K38_RS05275	COG1271	oxidase subunit
I6K38_RS05280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K38_RS05285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K38_RS05290	COG3842	ATPase activity
I6K38_RS05295	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K38_RS05300	COG1177	transmembrane transport
I6K38_RS05305	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS05340	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS05345	COG0747	negative chemotaxis
I6K38_RS05355	COG3238	Protein conserved in bacteria
I6K38_RS05360	COG1247	-acetyltransferase
I6K38_RS05370	COG2130	NADP-dependent
I6K38_RS05385	COG3691	Protein conserved in bacteria
I6K38_RS05390	COG1228	amidohydrolase
I6K38_RS05395	COG4772	TonB-dependent receptor
I6K38_RS05420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K38_RS05425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K38_RS05430	COG1473	amidohydrolase
I6K38_RS05435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K38_RS05440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS05450	COG0765	amino acid transport
I6K38_RS05455	COG1126	abc transporter atp-binding protein
I6K38_RS05465	COG0625	glutathione transferase activity
I6K38_RS05485	COG2211	Major facilitator Superfamily
I6K38_RS05500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K38_RS05505	COG3842	ATPase activity
I6K38_RS05510	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K38_RS05515	COG1178	ABC-type Fe3 transport system permease component
I6K38_RS05520	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K38_RS05525	COG2181	nitrate reductase activity
I6K38_RS05530	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K38_RS05535	COG1140	nitrate reductase beta subunit
I6K38_RS05540	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K38_RS05560	COG1414	Transcriptional regulator
I6K38_RS05565	COG4948	Mandelate Racemase Muconate Lactonizing
I6K38_RS05570	COG4829	muconolactone delta-isomerase
I6K38_RS05575	COG3485	protocatechuate 3,4-dioxygenase
I6K38_RS05585	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K38_RS05610	COG0437	4 iron, 4 sulfur cluster binding
I6K38_RS05615	COG2864	formate dehydrogenase
I6K38_RS05630	COG2326	polyphosphate kinase activity
I6K38_RS05640	COG2814	Major facilitator Superfamily
I6K38_RS05650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K38_RS05660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS05670	COG0747	negative chemotaxis
I6K38_RS05675	COG1064	alcohol dehydrogenase
I6K38_RS05690	COG0488	(ABC) transporter
I6K38_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS05735	COG3729	General stress protein
I6K38_RS05745	COG3685	Protein conserved in bacteria
I6K38_RS05755	COG0366	Alpha amylase catalytic
I6K38_RS05765	COG2323	membrane
I6K38_RS05775	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K38_RS05785	COG1764	response to oxidative stress
I6K38_RS05810	COG3781	membrane
I6K38_RS05815	COG0243	molybdopterin cofactor binding
I6K38_RS05820	COG0583	DNA-binding transcription factor activity
I6K38_RS05825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS05850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS05855	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K38_RS05860	COG2814	Major facilitator Superfamily
I6K38_RS05865	COG1285	pathogenesis
I6K38_RS05870	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K38_RS05890	COG0519	Catalyzes the synthesis of GMP from XMP
I6K38_RS05890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K38_RS05930	COG0596	Alpha beta hydrolase
I6K38_RS05940	COG2205	protein histidine kinase activity
I6K38_RS05955	COG0076	glutamate decarboxylase activity
I6K38_RS05960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K38_RS05965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K38_RS05970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K38_RS05975	COG1116	anion transmembrane transporter activity
I6K38_RS05980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K38_RS05995	COG0673	inositol 2-dehydrogenase activity
I6K38_RS06005	COG1609	Transcriptional regulator
I6K38_RS06010	COG3706	GGDEF domain
I6K38_RS06015	COG0402	S-adenosylhomocysteine deaminase activity
I6K38_RS06020	COG1953	Uracil, thiamine, allantoin
I6K38_RS06055	COG0596	Alpha beta hydrolase
I6K38_RS06065	COG2207	Transcriptional regulator
I6K38_RS06080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K38_RS06105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K38_RS06150	COG0765	amino acid transport
I6K38_RS06160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K38_RS06170	COG2070	2-Nitropropane dioxygenase
I6K38_RS06175	COG0583	DNA-binding transcription factor activity
I6K38_RS06185	COG1902	pentaerythritol trinitrate reductase activity
I6K38_RS06190	COG4529	Protein conserved in bacteria
I6K38_RS06195	COG0477	Major facilitator Superfamily
I6K38_RS06225	COG2223	nitrite transmembrane transporter activity
I6K38_RS06235	COG1609	Transcriptional regulator
I6K38_RS06240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS06250	COG3037	sugar-specific permease SgaT UlaA
I6K38_RS06255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K38_RS06265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS06270	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K38_RS06270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS06270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS06285	COG0583	DNA-binding transcription factor activity
I6K38_RS06290	COG0583	DNA-binding transcription factor activity
I6K38_RS06295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K38_RS06305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K38_RS06320	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS06330	COG1609	Transcriptional regulator
I6K38_RS06360	COG1652	LysM domain
I6K38_RS06385	COG0456	acetyltransferase
I6K38_RS06385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K38_RS06395	COG0667	Aldo Keto reductase
I6K38_RS06400	COG0667	Aldo Keto reductase
I6K38_RS06405	COG3386	PFAM SMP-30 Gluconolaconase
I6K38_RS06410	COG0667	Aldo Keto reductase
I6K38_RS06440	COG0251	oxidation-reduction process
I6K38_RS06445	COG0583	DNA-binding transcription factor activity
I6K38_RS06450	COG0626	cystathionine gamma-synthase activity
I6K38_RS06455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K38_RS06460	COG0814	amino acid
I6K38_RS06465	COG0583	DNA-binding transcription factor activity
I6K38_RS06475	COG1294	oxidase, subunit
I6K38_RS06480	COG1271	oxidase subunit
I6K38_RS06490	COG3118	belongs to the thioredoxin family
I6K38_RS06520	COG0583	DNA-binding transcription factor activity
I6K38_RS06560	COG1929	Belongs to the glycerate kinase type-1 family
I6K38_RS06565	COG3835	regulator
I6K38_RS06575	COG0583	DNA-binding transcription factor activity
I6K38_RS06585	COG2186	Transcriptional regulator
I6K38_RS06590	COG1263	PTS System
I6K38_RS06590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K38_RS06600	COG2814	Major facilitator Superfamily
I6K38_RS06605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS06605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS06620	COG2819	hydrolase of the alpha beta superfamily
I6K38_RS06625	COG5001	Diguanylate cyclase
I6K38_RS06625	COG3300	MHYT domain
I6K38_RS06660	COG3188	usher protein
I6K38_RS06670	COG1649	PFAM Uncharacterised BCR, COG1649
I6K38_RS06675	COG3550	peptidyl-serine autophosphorylation
I6K38_RS06680	COG1396	sequence-specific DNA binding
I6K38_RS06685	COG2351	hydroxyisourate hydrolase activity
I6K38_RS06690	COG3195	allantoin biosynthetic process
I6K38_RS06690	COG3648	Uricase
I6K38_RS06695	COG2233	PERMEase
I6K38_RS06725	COG2207	Transcriptional regulator
I6K38_RS06740	COG4628	conserved protein (DUF2132)
I6K38_RS06760	COG2011	ABC-type metal ion transport system permease component
I6K38_RS06765	COG2070	2-Nitropropane dioxygenase
I6K38_RS06775	COG0477	Major facilitator Superfamily
I6K38_RS06840	COG2199	diguanylate cyclase activity
I6K38_RS06855	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS06860	COG0583	DNA-binding transcription factor activity
I6K38_RS06870	COG0039	L-malate dehydrogenase activity
I6K38_RS06875	COG1349	DNA-binding transcription factor activity
I6K38_RS06880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K38_RS06895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K38_RS06900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K38_RS06905	COG2271	Major facilitator Superfamily
I6K38_RS06935	COG4977	sequence-specific DNA binding
I6K38_RS06945	COG0697	spore germination
I6K38_RS06950	COG2814	Major facilitator Superfamily
I6K38_RS06980	COG0683	leucine binding
I6K38_RS06985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K38_RS07020	COG2223	nitrite transmembrane transporter activity
I6K38_RS07025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K38_RS07040	COG1349	DNA-binding transcription factor activity
I6K38_RS07045	COG2084	Dehydrogenase
I6K38_RS07050	COG3395	kinase activity
I6K38_RS07055	COG0235	Class ii aldolase
I6K38_RS07060	COG3622	Belongs to the hyi family
I6K38_RS07070	COG2207	Transcriptional regulator
I6K38_RS07070	COG3708	Transcriptional regulator
I6K38_RS07085	COG2200	EAL domain
I6K38_RS07090	COG1546	Belongs to the CinA family
I6K38_RS07095	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K38_RS07115	COG2197	response regulator
I6K38_RS07130	COG2135	peptidase activity
I6K38_RS07135	COG2207	Transcriptional regulator
I6K38_RS07150	COG4221	oxidoreductase activity
I6K38_RS07155	COG1802	Transcriptional regulator
I6K38_RS07160	COG0589	response to stress
I6K38_RS07165	COG0246	Mannitol dehydrogenase
I6K38_RS07170	COG2271	Major facilitator Superfamily
I6K38_RS07185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K38_RS07200	COG0243	molybdopterin cofactor binding
I6K38_RS07205	COG0437	4 iron, 4 sulfur cluster binding
I6K38_RS07210	COG3302	dmso reductase anchor subunit
I6K38_RS07225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K38_RS07230	COG1940	carbohydrate kinase activity
I6K38_RS07235	COG0583	DNA-binding transcription factor activity
I6K38_RS07240	COG2814	Major facilitator Superfamily
I6K38_RS07245	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K38_RS07255	COG3591	Belongs to the peptidase S1B family
I6K38_RS07275	COG0628	permease
I6K38_RS07305	COG0679	Auxin Efflux Carrier
I6K38_RS07315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K38_RS07340	COG3290	protein histidine kinase activity
I6K38_RS07345	COG4565	transcriptional regulatory protein
I6K38_RS07365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K38_RS07365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K38_RS07375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K38_RS07380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K38_RS07390	COG0183	Belongs to the thiolase family
I6K38_RS07395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K38_RS07405	COG1414	Transcriptional regulator
I6K38_RS07410	COG2840	Smr protein MutS2
I6K38_RS07415	COG0583	DNA-binding transcription factor activity
I6K38_RS07425	COG1473	amidohydrolase
I6K38_RS07430	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K38_RS07555	COG4626	Terminase
I6K38_RS07555	COG1802	Transcriptional regulator
I6K38_RS07625	COG1403	HNH endonuclease
I6K38_RS07630	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K38_RS07640	COG1846	Transcriptional regulator
I6K38_RS07720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K38_RS07735	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K38_RS07740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K38_RS07755	COG0531	amino acid
I6K38_RS07765	COG3136	membrane protein required for alginate biosynthesis
I6K38_RS07770	COG0745	RESPONSE REGULATOR receiver
I6K38_RS07780	COG2205	protein histidine kinase activity
I6K38_RS07790	COG0114	fumarate hydratase activity
I6K38_RS07795	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K38_RS07795	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K38_RS07800	COG1482	cell wall glycoprotein biosynthetic process
I6K38_RS07805	COG5339	Protein conserved in bacteria
I6K38_RS07810	COG1609	Transcriptional regulator
I6K38_RS07815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K38_RS07815	COG1263	PTS System
I6K38_RS07820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K38_RS07845	COG2391	methyltransferase activity
I6K38_RS07850	COG0425	Belongs to the sulfur carrier protein TusA family
I6K38_RS07855	COG5562	phage envelope protein
I6K38_RS07860	COG0401	homolog of Blt101
I6K38_RS07865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K38_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS07880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K38_RS07885	COG0477	Major facilitator Superfamily
I6K38_RS07890	COG1113	amino acid transport
I6K38_RS07895	COG2988	succinylglutamate desuccinylase activity
I6K38_RS07900	COG3724	N-succinylarginine dihydrolase activity
I6K38_RS07905	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS07910	COG3138	arginine N-succinyltransferase
I6K38_RS07915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K38_RS07925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K38_RS07930	COG0667	Aldo Keto reductase
I6K38_RS07935	COG0583	DNA-binding transcription factor activity
I6K38_RS07965	COG1643	Atp-dependent helicase
I6K38_RS07980	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K38_RS07985	COG3327	negative regulation of DNA-templated transcription, initiation
I6K38_RS07990	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K38_RS07995	COG0183	Belongs to the thiolase family
I6K38_RS08000	COG2050	protein possibly involved in aromatic compounds catabolism
I6K38_RS08005	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K38_RS08010	COG1024	Enoyl-CoA hydratase
I6K38_RS08015	COG1024	Enoyl-CoA hydratase
I6K38_RS08020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K38_RS08025	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K38_RS08030	COG3396	Phenylacetate-CoA oxygenase
I6K38_RS08035	COG3460	Phenylacetate-CoA oxygenase
I6K38_RS08040	COG3396	Phenylacetate-CoA oxygenase
I6K38_RS08045	COG2030	dehydratase
I6K38_RS08045	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS08065	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS08070	COG2207	Transcriptional regulator
I6K38_RS08075	COG3784	Protein of unknown function (DUF1318)
I6K38_RS08085	COG2911	Protein conserved in bacteria
I6K38_RS08090	COG0586	Pfam SNARE associated Golgi protein
I6K38_RS08095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K38_RS08100	COG3187	Heat shock protein
I6K38_RS08105	COG3042	response to heat
I6K38_RS08110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K38_RS08110	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K38_RS08110	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K38_RS08110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K38_RS08115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K38_RS08125	COG0589	response to stress
I6K38_RS08135	COG0513	Belongs to the DEAD box helicase family
I6K38_RS08145	COG1349	DNA-binding transcription factor activity
I6K38_RS08150	COG0673	inositol 2-dehydrogenase activity
I6K38_RS08165	COG1113	amino acid transport
I6K38_RS08170	COG1522	sequence-specific DNA binding
I6K38_RS08180	COG1448	Aminotransferase
I6K38_RS08185	COG2011	ABC-type metal ion transport system permease component
I6K38_RS08195	COG1464	Belongs to the NlpA lipoprotein family
I6K38_RS08200	COG0436	Aminotransferase
I6K38_RS08205	COG0604	alcohol dehydrogenase
I6K38_RS08235	COG0583	DNA-binding transcription factor activity
I6K38_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS08260	COG1309	transcriptional regulator
I6K38_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS08370	COG2885	chlorophyll binding
I6K38_RS08395	COG0693	protein deglycase activity
I6K38_RS08400	COG1078	dGTPase activity
I6K38_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS08410	COG0583	DNA-binding transcription factor activity
I6K38_RS08470	COG0784	Response regulator, receiver
I6K38_RS08470	COG2205	protein histidine kinase activity
I6K38_RS08470	COG5002	protein histidine kinase activity
I6K38_RS08475	COG3250	beta-galactosidase activity
I6K38_RS08480	COG0656	L-ascorbic acid biosynthetic process
I6K38_RS08510	COG4166	transmembrane transport
I6K38_RS08520	COG2866	Carboxypeptidase
I6K38_RS08525	COG4948	Mandelate Racemase Muconate Lactonizing
I6K38_RS08530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K38_RS08535	COG3180	Ammonia monooxygenase
I6K38_RS08545	COG1486	melibiose metabolic process
I6K38_RS08550	COG0583	DNA-binding transcription factor activity
I6K38_RS08560	COG3106	COG3106 Predicted ATPase
I6K38_RS08570	COG1983	PspC domain protein
I6K38_RS08580	COG1842	Phage shock protein A
I6K38_RS08585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K38_RS08595	COG1473	amidohydrolase
I6K38_RS08610	COG0702	epimerase
I6K38_RS08625	COG4171	peptide transport system, permease
I6K38_RS08640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K38_RS08650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K38_RS08655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K38_RS08655	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K38_RS08670	COG1349	DNA-binding transcription factor activity
I6K38_RS08680	COG0023	Translation Initiation Factor
I6K38_RS08690	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K38_RS08695	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K38_RS08700	COG0671	phosphoesterase, PA-phosphatase related
I6K38_RS08710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K38_RS08735	COG0616	signal peptide processing
I6K38_RS08745	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS08750	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K38_RS08815	COG0582	viral genome integration into host DNA
I6K38_RS08850	COG0583	DNA-binding transcription factor activity
I6K38_RS08860	COG0009	L-threonylcarbamoyladenylate synthase
I6K38_RS08870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K38_RS08875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K38_RS08875	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K38_RS08880	COG0135	phosphoribosylanthranilate isomerase activity
I6K38_RS08880	COG0134	indole-3-glycerol-phosphate synthase activity
I6K38_RS08935	COG4774	siderophore transport
I6K38_RS08945	COG3047	cAMP biosynthetic process
I6K38_RS08950	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K38_RS08980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K38_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS08990	COG1988	membrane-bound metal-dependent
I6K38_RS08995	COG1823	symporter activity
I6K38_RS09005	COG0753	catalase activity
I6K38_RS09015	COG1486	melibiose metabolic process
I6K38_RS09020	COG2169	Transcriptional regulator
I6K38_RS09020	COG1917	Cupin 2, conserved barrel domain protein
I6K38_RS09025	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K38_RS09030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS09040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS09045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K38_RS09055	COG0322	excinuclease ABC activity
I6K38_RS09060	COG3678	ATP-independent chaperone mediated protein folding
I6K38_RS09070	COG3724	N-succinylarginine dihydrolase activity
I6K38_RS09080	COG3138	arginine N-succinyltransferase
I6K38_RS09090	COG0708	Exodeoxyribonuclease III
I6K38_RS09095	COG0398	Pfam SNARE associated Golgi protein
I6K38_RS09100	COG0398	Pfam SNARE associated Golgi protein
I6K38_RS09105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K38_RS09110	COG4134	Bacterial extracellular solute-binding protein
I6K38_RS09115	COG4135	transport system, permease component
I6K38_RS09130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K38_RS09135	COG0494	nUDIX hydrolase
I6K38_RS09140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K38_RS09145	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS09145	COG0604	alcohol dehydrogenase
I6K38_RS09145	COG3321	synthase
I6K38_RS09150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K38_RS09155	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K38_RS09165	COG0778	Nitroreductase
I6K38_RS09170	COG0616	signal peptide processing
I6K38_RS09175	COG0252	asparaginase activity
I6K38_RS09180	COG1335	isochorismatase
I6K38_RS09195	COG3139	Protein of unknown function (DUF1315)
I6K38_RS09215	COG0656	L-ascorbic acid biosynthetic process
I6K38_RS09220	COG3713	MltA-interacting MipA family protein
I6K38_RS09225	COG2766	serine protein kinase
I6K38_RS09240	COG0386	Belongs to the glutathione peroxidase family
I6K38_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS09270	COG0583	DNA-binding transcription factor activity
I6K38_RS09275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K38_RS09280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K38_RS09290	COG0859	PFAM glycosyl transferase family 9
I6K38_RS09295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K38_RS09305	COG2207	Transcriptional regulator
I6K38_RS09310	COG2807	transmembrane transport
I6K38_RS09315	COG0504	CTP synthase activity
I6K38_RS09320	COG1683	Conserved Protein
I6K38_RS09325	COG3189	MarR family transcriptional regulator
I6K38_RS09330	COG3042	response to heat
I6K38_RS09335	COG2199	diguanylate cyclase activity
I6K38_RS09335	COG2203	Gaf domain
I6K38_RS09355	COG3182	Iron-regulated membrane protein
I6K38_RS09365	COG1560	Kdo2-lipid A biosynthetic process
I6K38_RS09375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K38_RS09380	COG3706	GGDEF domain
I6K38_RS09385	COG0583	DNA-binding transcription factor activity
I6K38_RS09390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K38_RS09420	COG1294	oxidase, subunit
I6K38_RS09425	COG1271	oxidase subunit
I6K38_RS09430	COG3546	catalase activity
I6K38_RS09435	COG3685	Protein conserved in bacteria
I6K38_RS09440	COG3685	Protein conserved in bacteria
I6K38_RS09445	COG3729	General stress protein
I6K38_RS09450	COG1063	alcohol dehydrogenase
I6K38_RS09455	COG3813	Protein conserved in bacteria
I6K38_RS09475	COG0640	Transcriptional regulator
I6K38_RS09480	COG0538	isocitrate dehydrogenase activity
I6K38_RS09555	COG0740	serine-type endopeptidase activity
I6K38_RS09605	COG3772	lysozyme
I6K38_RS09620	COG1403	HNH endonuclease
I6K38_RS09685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K38_RS09695	COG0582	viral genome integration into host DNA
I6K38_RS09700	COG0538	isocitrate dehydrogenase activity
I6K38_RS09705	COG1187	pseudouridine synthase activity
I6K38_RS09725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K38_RS09745	COG2205	protein histidine kinase activity
I6K38_RS09750	COG2850	peptidyl-arginine hydroxylation
I6K38_RS09770	COG1177	transmembrane transport
I6K38_RS09785	COG0318	PFAM AMP-dependent synthetase and ligase
I6K38_RS09790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K38_RS09795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K38_RS09800	COG0698	ribose 5-phosphate isomerase
I6K38_RS09815	COG3395	kinase activity
I6K38_RS09830	COG2390	Transcriptional regulator
I6K38_RS09840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K38_RS09850	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K38_RS09860	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K38_RS09870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K38_RS09875	COG1388	LysM domain
I6K38_RS09875	COG1376	ErfK ybiS ycfS ynhG family protein
I6K38_RS09890	COG1309	transcriptional regulator
I6K38_RS09905	COG3134	Outer membrane lipoprotein
I6K38_RS09910	COG1252	NADH dehydrogenase
I6K38_RS09935	COG5633	Lipoprotein
I6K38_RS09940	COG0537	adenosine 5'-monophosphoramidase activity
I6K38_RS09950	COG0084	hydrolase, TatD family'
I6K38_RS09955	COG0470	DNA polymerase III
I6K38_RS09965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K38_RS09970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K38_RS09975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K38_RS09990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K38_RS10010	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K38_RS10030	COG1530	ribonuclease E activity
I6K38_RS10035	COG0583	DNA-binding transcription factor activity
I6K38_RS10040	COG2814	Major facilitator Superfamily
I6K38_RS10060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K38_RS10105	COG1560	Kdo2-lipid A biosynthetic process
I6K38_RS10120	COG5645	(Lipo)protein
I6K38_RS10155	COG3381	protein complex oligomerization
I6K38_RS10180	COG0583	DNA-binding transcription factor activity
I6K38_RS10190	COG1335	isochorismatase
I6K38_RS10200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K38_RS10205	COG1702	phosphate starvation-inducible protein PhoH
I6K38_RS10225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K38_RS10235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K38_RS10250	COG1309	transcriptional regulator
I6K38_RS10285	COG2233	PERMEase
I6K38_RS10295	COG3729	General stress protein
I6K38_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS10340	COG0531	amino acid
I6K38_RS10345	COG0174	glutamine synthetase
I6K38_RS10350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K38_RS10355	COG1917	Cupin 2, conserved barrel domain protein
I6K38_RS10355	COG1396	sequence-specific DNA binding
I6K38_RS10360	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS10365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K38_RS10370	COG0583	DNA-binding transcription factor activity
I6K38_RS10375	COG0473	3-isopropylmalate dehydrogenase activity
I6K38_RS10380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K38_RS10385	COG4638	Rieske (2fe-2S)
I6K38_RS10390	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS10395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K38_RS10400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS10400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K38_RS10400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS10405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS10410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS10415	COG1882	Formate acetyltransferase
I6K38_RS10420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K38_RS10425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K38_RS10435	COG2207	Transcriptional regulator
I6K38_RS10440	COG3706	GGDEF domain
I6K38_RS10460	COG2200	EAL domain
I6K38_RS10470	COG0058	SHG alpha-glucan phosphorylase activity
I6K38_RS10485	COG0670	Belongs to the BI1 family
I6K38_RS10500	COG2207	Transcriptional regulator
I6K38_RS10505	COG1881	PFAM PEBP family protein
I6K38_RS10530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS10535	COG2274	protein secretion by the type I secretion system
I6K38_RS10550	COG1832	CoA-binding protein
I6K38_RS10560	COG0210	DNA helicase
I6K38_RS10565	COG3304	Inner membrane component domain
I6K38_RS10570	COG1289	transmembrane transporter activity
I6K38_RS10575	COG3070	regulator of competence-specific genes
I6K38_RS10595	COG1067	ATP-dependent peptidase activity
I6K38_RS10605	COG3130	regulation of translation
I6K38_RS10610	COG3009	Protein conserved in bacteria
I6K38_RS10615	COG3008	intermembrane lipid transfer
I6K38_RS10615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K38_RS10620	COG2995	paraquat-inducible protein a
I6K38_RS10625	COG0488	(ABC) transporter
I6K38_RS10635	COG0633	Ferredoxin
I6K38_RS10635	COG3217	Mosc domain protein beta barrel domain protein
I6K38_RS10650	COG0431	NADPH-dependent FMN reductase
I6K38_RS10655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K38_RS10660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K38_RS10665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K38_RS10675	COG0308	aminopeptidase N
I6K38_RS10685	COG1473	amidohydrolase
I6K38_RS10695	COG0814	amino acid
I6K38_RS10715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K38_RS10720	COG1448	Aminotransferase
I6K38_RS10725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K38_RS10730	COG3108	Peptidase M15
I6K38_RS10735	COG2989	Protein conserved in bacteria
I6K38_RS10745	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K38_RS10755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K38_RS10760	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K38_RS10765	COG3173	Aminoglycoside phosphotransferase
I6K38_RS10780	COG3214	Protein conserved in bacteria
I6K38_RS10795	COG2333	competence protein COMEC
I6K38_RS10795	COG0658	competence protein
I6K38_RS10805	COG0539	negative regulation of cytoplasmic translation
I6K38_RS10825	COG2323	membrane
I6K38_RS10830	COG1944	ATP diphosphatase activity
I6K38_RS10835	COG2116	formate transmembrane transporter activity
I6K38_RS10840	COG1882	Formate acetyltransferase
I6K38_RS10845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K38_RS10850	COG0477	Major facilitator Superfamily
I6K38_RS10855	COG3302	dmso reductase anchor subunit
I6K38_RS10860	COG0437	4 iron, 4 sulfur cluster binding
I6K38_RS10865	COG0243	molybdopterin cofactor binding
I6K38_RS10875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K38_RS10885	COG1178	ABC-type Fe3 transport system permease component
I6K38_RS10885	COG1674	ftsk spoiiie
I6K38_RS10895	COG0492	ferredoxin-NADP+ reductase activity
I6K38_RS10900	COG4988	ABC transporter
I6K38_RS10905	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K38_RS10920	COG0542	response to heat
I6K38_RS10930	COG1278	Cold shock
I6K38_RS10940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS10945	COG3593	DNA synthesis involved in DNA repair
I6K38_RS10955	COG2431	L-lysine efflux transmembrane transporter activity
I6K38_RS10965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K38_RS10975	COG0028	Belongs to the TPP enzyme family
I6K38_RS10980	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K38_RS10985	COG0702	epimerase
I6K38_RS10990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K38_RS10995	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K38_RS11000	COG3706	GGDEF domain
I6K38_RS11000	COG4251	negative regulation of phosphorylation
I6K38_RS11000	COG5001	Diguanylate cyclase
I6K38_RS11000	COG2203	Gaf domain
I6K38_RS11010	COG1126	abc transporter atp-binding protein
I6K38_RS11015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS11020	COG4215	(ABC) transporter
I6K38_RS11025	COG4160	amino acid transport
I6K38_RS11030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS11035	COG5002	protein histidine kinase activity
I6K38_RS11040	COG0745	RESPONSE REGULATOR receiver
I6K38_RS11055	COG1177	transmembrane transport
I6K38_RS11060	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K38_RS11065	COG3842	ATPase activity
I6K38_RS11070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K38_RS11085	COG0778	Nitroreductase
I6K38_RS11150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K38_RS11260	COG4695	Portal protein
I6K38_RS11295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K38_RS11335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6K38_RS11340	COG3226	Transcriptional regulator
I6K38_RS11345	COG0738	Major facilitator superfamily
I6K38_RS11350	COG0561	phosphatase activity
I6K38_RS11355	COG2814	Major facilitator Superfamily
I6K38_RS11360	COG0671	phosphoesterase, PA-phosphatase related
I6K38_RS11365	COG1349	DNA-binding transcription factor activity
I6K38_RS11370	COG1686	Belongs to the peptidase S11 family
I6K38_RS11380	COG0625	glutathione transferase activity
I6K38_RS11385	COG2133	pyrroloquinoline quinone binding
I6K38_RS11395	COG2223	nitrite transmembrane transporter activity
I6K38_RS11415	COG0747	negative chemotaxis
I6K38_RS11430	COG0303	'Molybdopterin
I6K38_RS11435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K38_RS11440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K38_RS11445	COG1882	Formate acetyltransferase
I6K38_RS11450	COG0561	phosphatase activity
I6K38_RS11460	COG1609	Transcriptional regulator
I6K38_RS11465	COG2271	Major facilitator Superfamily
I6K38_RS11475	COG0488	(ABC) transporter
I6K38_RS11480	COG2365	Tyrosine phosphatase family
I6K38_RS11485	COG1376	ErfK ybiS ycfS ynhG family protein
I6K38_RS11490	COG2188	Transcriptional regulator
I6K38_RS11495	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS11500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K38_RS11515	COG2194	sulfuric ester hydrolase activity
I6K38_RS11520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K38_RS11535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS11540	COG0765	amino acid transport
I6K38_RS11545	COG1126	abc transporter atp-binding protein
I6K38_RS11550	COG0668	transmembrane transport
I6K38_RS11560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K38_RS11570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K38_RS11580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K38_RS11585	COG1199	ATP-dependent helicase activity
I6K38_RS11590	COG0513	Belongs to the DEAD box helicase family
I6K38_RS11595	COG3958	Transketolase
I6K38_RS11600	COG3959	Transketolase, thiamine diphosphate binding domain
I6K38_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS11610	COG2271	Major facilitator Superfamily
I6K38_RS11620	COG0583	DNA-binding transcription factor activity
I6K38_RS11625	COG1309	transcriptional regulator
I6K38_RS11630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS11635	COG1131	(ABC) transporter
I6K38_RS11640	COG0842	Transport permease protein
I6K38_RS11645	COG0842	Transport permease protein
I6K38_RS11655	COG3568	Endonuclease Exonuclease Phosphatase
I6K38_RS11660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K38_RS11665	COG0392	lysyltransferase activity
I6K38_RS11670	COG0670	Belongs to the BI1 family
I6K38_RS11675	COG0314	molybdopterin synthase activity
I6K38_RS11680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K38_RS11690	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K38_RS11710	COG0745	RESPONSE REGULATOR receiver
I6K38_RS11715	COG0642	Histidine kinase
I6K38_RS11740	COG2226	methyltransferase
I6K38_RS11755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K38_RS11760	COG1881	PFAM PEBP family protein
I6K38_RS11800	COG4677	pectinesterase activity
I6K38_RS11810	COG0589	response to stress
I6K38_RS11815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS11850	COG0789	Transcriptional regulator
I6K38_RS11855	COG2200	EAL domain
I6K38_RS11880	COG0561	phosphatase activity
I6K38_RS11890	COG4149	molybdate abc transporter
I6K38_RS11895	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K38_RS11905	COG2005	Transcriptional regulator
I6K38_RS11905	COG3585	molybdate ion transport
I6K38_RS11910	COG1119	ATPase activity
I6K38_RS11920	COG1085	galactose-1-phosphate uridylyltransferase
I6K38_RS11930	COG2017	converts alpha-aldose to the beta-anomer
I6K38_RS11940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K38_RS11955	COG3201	nicotinamide mononucleotide transporter
I6K38_RS11960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K38_RS12005	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K38_RS12010	COG2885	chlorophyll binding
I6K38_RS12020	COG3064	Membrane
I6K38_RS12025	COG0848	biopolymer transport protein
I6K38_RS12030	COG0811	peptide transport
I6K38_RS12035	COG0824	Thioesterase
I6K38_RS12040	COG3790	cyd operon protein YbgE
I6K38_RS12045	COG4890	Cyd operon protein YbgT
I6K38_RS12050	COG1294	oxidase, subunit
I6K38_RS12055	COG1271	oxidase subunit
I6K38_RS12060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K38_RS12070	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K38_RS12075	COG0567	Dehydrogenase, E1 component
I6K38_RS12080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K38_RS12085	COG1053	succinate dehydrogenase
I6K38_RS12090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K38_RS12095	COG2009	succinate dehydrogenase
I6K38_RS12130	COG1984	allophanate hydrolase subunit 2
I6K38_RS12135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K38_RS12150	COG0415	Belongs to the DNA photolyase family
I6K38_RS12180	COG2205	protein histidine kinase activity
I6K38_RS12185	COG0745	RESPONSE REGULATOR receiver
I6K38_RS12195	COG0033	Phosphoglucomutase
I6K38_RS12205	COG0596	Alpha beta hydrolase
I6K38_RS12220	COG0735	belongs to the Fur family
I6K38_RS12260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K38_RS12265	COG1940	carbohydrate kinase activity
I6K38_RS12265	COG1846	Transcriptional regulator
I6K38_RS12270	COG0647	UMP catabolic process
I6K38_RS12275	COG0367	asparagine synthase
I6K38_RS12315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K38_RS12325	COG1702	phosphate starvation-inducible protein PhoH
I6K38_RS12350	COG0765	amino acid transport
I6K38_RS12355	COG0765	amino acid transport
I6K38_RS12360	COG1126	abc transporter atp-binding protein
I6K38_RS12375	COG2888	peptidyl-tyrosine sulfation
I6K38_RS12390	COG1466	dna polymerase III delta subunit
I6K38_RS12405	COG0799	negative regulation of ribosome biogenesis
I6K38_RS12415	COG0768	penicillin binding
I6K38_RS12420	COG0772	Belongs to the SEDS family
I6K38_RS12425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K38_RS12430	COG1686	Belongs to the peptidase S11 family
I6K38_RS12445	COG0583	DNA-binding transcription factor activity
I6K38_RS12455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K38_RS12460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K38_RS12480	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K38_RS12485	COG3719	Belongs to the RNase T2 family
I6K38_RS12490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K38_RS12510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K38_RS12515	COG0583	DNA-binding transcription factor activity
I6K38_RS12520	COG3969	phosphoadenosine phosphosulfate
I6K38_RS12525	COG1475	DNA binding
I6K38_RS12530	COG0436	Aminotransferase
I6K38_RS12555	COG1129	ABC transporter
I6K38_RS12560	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS12565	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS12575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K38_RS12590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K38_RS12600	COG0402	S-adenosylhomocysteine deaminase activity
I6K38_RS12610	COG0483	inositol monophosphate 1-phosphatase activity
I6K38_RS12615	COG2271	Major facilitator Superfamily
I6K38_RS12645	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS12650	COG1129	ABC transporter
I6K38_RS12655	COG0371	Dehydrogenase
I6K38_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS12675	COG2879	small protein
I6K38_RS12680	COG1966	Carbon starvation protein
I6K38_RS12690	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS12695	COG1535	isochorismatase
I6K38_RS12695	COG3433	isochorismatase activity
I6K38_RS12700	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K38_RS12705	COG1169	isochorismate synthase
I6K38_RS12710	COG4592	Periplasmic binding protein
I6K38_RS12720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS12725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS12730	COG1120	ATPase activity
I6K38_RS12735	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K38_RS12735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K38_RS12740	COG3251	PFAM MbtH domain protein
I6K38_RS12745	COG2382	esterase
I6K38_RS12750	COG4771	TonB-dependent receptor
I6K38_RS12760	COG1879	ABC-type sugar transport system periplasmic component
I6K38_RS12770	COG1129	ABC transporter
I6K38_RS12775	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS12780	COG5464	transposase or invertase
I6K38_RS12785	COG2390	Transcriptional regulator
I6K38_RS12790	COG3959	Transketolase, thiamine diphosphate binding domain
I6K38_RS12795	COG3958	Transketolase
I6K38_RS12805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K38_RS12815	COG0583	DNA-binding transcription factor activity
I6K38_RS12820	COG0668	transmembrane transport
I6K38_RS12830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K38_RS12855	COG0747	negative chemotaxis
I6K38_RS12860	COG0601	transmembrane transport
I6K38_RS12865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS12870	COG0444	Belongs to the ABC transporter superfamily
I6K38_RS12875	COG4608	Belongs to the ABC transporter superfamily
I6K38_RS12880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K38_RS12885	COG4221	oxidoreductase activity
I6K38_RS12895	COG4215	(ABC) transporter
I6K38_RS12900	COG0765	amino acid transport
I6K38_RS12905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K38_RS12920	COG0697	spore germination
I6K38_RS12935	COG4608	Belongs to the ABC transporter superfamily
I6K38_RS12940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS12950	COG4166	transmembrane transport
I6K38_RS12960	COG3698	Phosphodiester glycosidase
I6K38_RS13000	COG2315	Protein conserved in bacteria
I6K38_RS13005	COG0778	Nitroreductase
I6K38_RS13030	COG0477	Major facilitator Superfamily
I6K38_RS13035	COG0668	transmembrane transport
I6K38_RS13040	COG1609	Transcriptional regulator
I6K38_RS13050	COG0673	inositol 2-dehydrogenase activity
I6K38_RS13060	COG2211	Major facilitator Superfamily
I6K38_RS13065	COG1113	amino acid transport
I6K38_RS13080	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS13085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K38_RS13095	COG0531	amino acid
I6K38_RS13110	COG4680	protein conserved in bacteria
I6K38_RS13150	COG0667	Aldo Keto reductase
I6K38_RS13155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS13160	COG1473	amidohydrolase
I6K38_RS13190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS13195	COG1120	ATPase activity
I6K38_RS13200	COG1566	PFAM secretion protein HlyD family protein
I6K38_RS13245	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS13250	COG1129	ABC transporter
I6K38_RS13265	COG0673	inositol 2-dehydrogenase activity
I6K38_RS13295	COG3104	oligopeptide transport
I6K38_RS13300	COG1982	Orn Lys Arg decarboxylase major
I6K38_RS13305	COG0531	amino acid
I6K38_RS13310	COG3710	Transcriptional regulator
I6K38_RS13320	COG1560	Kdo2-lipid A biosynthetic process
I6K38_RS13365	COG2501	S4 domain
I6K38_RS13375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K38_RS13390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K38_RS13395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K38_RS13415	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K38_RS13420	COG4181	ATPase activity
I6K38_RS13425	COG2755	lipolytic protein G-D-S-L family
I6K38_RS13430	COG0300	oxidoreductase activity
I6K38_RS13435	COG3118	belongs to the thioredoxin family
I6K38_RS13440	COG0390	transport system, permease component
I6K38_RS13445	COG4619	ABC transporter
I6K38_RS13450	COG0330	HflC and HflK could
I6K38_RS13455	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K38_RS13470	COG3735	TraB family
I6K38_RS13475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K38_RS13485	COG2223	nitrite transmembrane transporter activity
I6K38_RS13490	COG4651	solute:proton antiporter activity
I6K38_RS13490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K38_RS13495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K38_RS13535	COG2832	Protein of unknown function (DUF454)
I6K38_RS13540	COG3923	Primosomal replication protein n
I6K38_RS13550	COG5464	transposase or invertase
I6K38_RS13555	COG3264	Mechanosensitive ion channel
I6K38_RS13555	COG1196	nuclear chromosome segregation
I6K38_RS13560	COG1309	transcriptional regulator
I6K38_RS13565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS13570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K38_RS13585	COG0110	maltose O-acetyltransferase activity
I6K38_RS13635	COG1874	Beta-galactosidase
I6K38_RS13640	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K38_RS13645	COG3833	ABC-type maltose transport systems, permease component
I6K38_RS13650	COG1175	transmembrane transport
I6K38_RS13655	COG2182	Extracellular solute-binding protein
I6K38_RS13665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K38_RS13680	COG2364	Membrane
I6K38_RS13710	COG3695	enzyme binding
I6K38_RS13715	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K38_RS13720	COG1946	Acyl-CoA thioesterase
I6K38_RS13725	COG0004	ammonium transporteR
I6K38_RS13730	COG0347	Belongs to the P(II) protein family
I6K38_RS13735	COG1132	(ABC) transporter
I6K38_RS13740	COG1132	(ABC) transporter
I6K38_RS13745	COG1522	sequence-specific DNA binding
I6K38_RS13760	COG4533	DNA binding
I6K38_RS13770	COG0824	Thioesterase
I6K38_RS13775	COG1555	photosystem II stabilization
I6K38_RS13780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K38_RS13785	COG0776	regulation of translation
I6K38_RS13790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K38_RS13810	COG0271	Belongs to the BolA IbaG family
I6K38_RS13815	COG3056	Lipoprotein
I6K38_RS13820	COG2223	nitrite transmembrane transporter activity
I6K38_RS13825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K38_RS13830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K38_RS13835	COG1845	cytochrome c oxidase, subunit III
I6K38_RS13840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K38_RS13855	COG1414	Transcriptional regulator
I6K38_RS13860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K38_RS13865	COG1053	succinate dehydrogenase
I6K38_RS13875	COG1053	succinate dehydrogenase
I6K38_RS13890	COG0673	inositol 2-dehydrogenase activity
I6K38_RS13895	COG2814	Major facilitator Superfamily
I6K38_RS13905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K38_RS13910	COG0693	protein deglycase activity
I6K38_RS13930	COG0142	geranyltranstransferase activity
I6K38_RS13940	COG0667	Aldo Keto reductase
I6K38_RS13945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K38_RS13965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K38_RS13965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K38_RS13975	COG4238	major outer membrane lipoprotein
I6K38_RS13995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K38_RS14000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K38_RS14005	COG1862	Preprotein translocase
I6K38_RS14030	COG0450	alkyl hydroperoxide reductase
I6K38_RS14040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS14055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K38_RS14065	COG1228	amidohydrolase
I6K38_RS14075	COG1335	isochorismatase
I6K38_RS14080	COG0583	DNA-binding transcription factor activity
I6K38_RS14085	COG0366	Alpha amylase catalytic
I6K38_RS14110	COG0420	3'-5' exonuclease activity
I6K38_RS14115	COG0419	ATPase involved in DNA repair
I6K38_RS14120	COG1940	carbohydrate kinase activity
I6K38_RS14135	COG4126	flavin adenine dinucleotide binding
I6K38_RS14145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K38_RS14150	COG3416	Protein conserved in bacteria
I6K38_RS14160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K38_RS14170	COG1785	Belongs to the alkaline phosphatase family
I6K38_RS14210	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K38_RS14215	COG1335	isochorismatase
I6K38_RS14220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K38_RS14225	COG0113	porphobilinogen synthase activity
I6K38_RS14230	COG1943	Transposase
I6K38_RS14240	COG2175	clavaminate synthase activity
I6K38_RS14245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K38_RS14250	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K38_RS14255	COG4521	taurine ABC transporter
I6K38_RS14260	COG2040	homocysteine
I6K38_RS14265	COG0833	amino acid
I6K38_RS14280	COG4303	Ethanolamine ammonia lyase large subunit
I6K38_RS14285	COG4302	ethanolamine ammonia-lyase activity
I6K38_RS14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS14330	COG1126	abc transporter atp-binding protein
I6K38_RS14335	COG4597	amino acid ABC transporter
I6K38_RS14340	COG0765	amino acid transport
I6K38_RS14355	COG3188	usher protein
I6K38_RS14380	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K38_RS14390	COG3639	organic phosphonate transmembrane transporter activity
I6K38_RS14405	COG0791	NLP P60 protein
I6K38_RS14430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6K38_RS14455	COG2909	trisaccharide binding
I6K38_RS14460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K38_RS14465	COG0022	dehydrogenase e1 component
I6K38_RS14470	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K38_RS14475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K38_RS14495	COG1070	Carbohydrate kinase
I6K38_RS14500	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS14505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K38_RS14510	COG3775	system Galactitol-specific IIC component
I6K38_RS14515	COG0625	glutathione transferase activity
I6K38_RS14520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K38_RS14535	COG0579	oxidoreductase
I6K38_RS14540	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS14545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K38_RS14550	COG1113	amino acid transport
I6K38_RS14555	COG1802	Transcriptional regulator
I6K38_RS14575	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K38_RS14580	COG0454	-acetyltransferase
I6K38_RS14595	COG2991	Protein conserved in bacteria
I6K38_RS14610	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K38_RS14615	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K38_RS14630	COG3034	peptidoglycan biosynthetic process
I6K38_RS14635	COG0121	glutamine amidotransferase
I6K38_RS14645	COG1960	acyl-CoA dehydrogenase activity
I6K38_RS14650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K38_RS14660	COG0583	DNA-binding transcription factor activity
I6K38_RS14670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K38_RS14680	COG2226	methyltransferase
I6K38_RS14690	COG0741	lytic transglycosylase activity
I6K38_RS14690	COG1388	LysM domain
I6K38_RS14695	COG2226	methyltransferase
I6K38_RS14705	COG2814	Major facilitator Superfamily
I6K38_RS14710	COG0583	DNA-binding transcription factor activity
I6K38_RS14715	COG0656	L-ascorbic acid biosynthetic process
I6K38_RS14750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K38_RS14760	COG2011	ABC-type metal ion transport system permease component
I6K38_RS14765	COG1464	Belongs to the NlpA lipoprotein family
I6K38_RS14775	COG1720	tRNA m6t6A37 methyltransferase activity
I6K38_RS14785	COG0791	NLP P60 protein
I6K38_RS14790	COG3015	lipoprotein NlpE involved in copper resistance
I6K38_RS14795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K38_RS14810	COG4568	rho-dependent transcription termination
I6K38_RS14820	COG0346	lactoylglutathione lyase activity
I6K38_RS14825	COG1982	Orn Lys Arg decarboxylase major
I6K38_RS14835	COG0587	DNA-directed DNA polymerase activity
I6K38_RS14865	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K38_RS14875	COG0750	zinc metalloprotease
I6K38_RS14880	COG0575	Belongs to the CDS family
I6K38_RS14890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K38_RS14915	COG0024	Methionine aminopeptidase
I6K38_RS14920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K38_RS14935	COG3835	regulator
I6K38_RS14940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K38_RS14960	COG2860	membrane
I6K38_RS14980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS14985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K38_RS14990	COG1120	ATPase activity
I6K38_RS14995	COG4774	siderophore transport
I6K38_RS15000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K38_RS15090	COG1643	Atp-dependent helicase
I6K38_RS15095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K38_RS15115	COG0617	tRNA 3'-terminal CCA addition
I6K38_RS15120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K38_RS15140	COG0726	polysaccharide deacetylase
I6K38_RS15145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS15150	COG0842	Transport permease protein
I6K38_RS15155	COG1131	(ABC) transporter
I6K38_RS15160	COG0288	reversible hydration of carbon dioxide
I6K38_RS15175	COG4993	Dehydrogenase
I6K38_RS15180	COG2132	Multicopper oxidase
I6K38_RS15225	COG3064	Membrane
I6K38_RS15240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K38_RS15245	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K38_RS15250	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K38_RS15255	COG2186	Transcriptional regulator
I6K38_RS15260	COG1113	amino acid transport
I6K38_RS15265	COG2211	Major facilitator Superfamily
I6K38_RS15270	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K38_RS15275	COG3725	Membrane protein required for beta-lactamase induction
I6K38_RS15280	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K38_RS15290	COG4969	Belongs to the N-Me-Phe pilin family
I6K38_RS15295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K38_RS15300	COG1459	type II secretion system
I6K38_RS15325	COG0494	nUDIX hydrolase
I6K38_RS15345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K38_RS15350	COG0849	cell division
I6K38_RS15375	COG0772	Belongs to the SEDS family
I6K38_RS15390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K38_RS15395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K38_RS15400	COG0768	penicillin binding
I6K38_RS15420	COG1609	Transcriptional regulator
I6K38_RS15430	COG0028	Belongs to the TPP enzyme family
I6K38_RS15475	COG0738	Major facilitator superfamily
I6K38_RS15485	COG0583	DNA-binding transcription factor activity
I6K38_RS15490	COG2271	Major facilitator Superfamily
I6K38_RS15495	COG2814	Major facilitator Superfamily
I6K38_RS15515	COG1178	ABC-type Fe3 transport system permease component
I6K38_RS15525	COG0586	Pfam SNARE associated Golgi protein
I6K38_RS15545	COG0235	Class ii aldolase
I6K38_RS15550	COG0417	DNA replication proofreading
I6K38_RS15560	COG0564	pseudouridine synthase activity
I6K38_RS15570	COG3493	citrate carrier protein
I6K38_RS15585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K38_RS15590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K38_RS15600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K38_RS15645	COG0505	Belongs to the CarA family
I6K38_RS15655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K38_RS15665	COG3152	Membrane
I6K38_RS15680	COG1047	Peptidyl-prolyl cis-trans
I6K38_RS15695	COG0196	riboflavin kinase activity
I6K38_RS15705	COG0583	DNA-binding transcription factor activity
I6K38_RS15730	COG4735	regulation of single-species biofilm formation
I6K38_RS15735	COG1584	GPR1 FUN34 yaaH family protein
I6K38_RS15740	COG0477	Major facilitator Superfamily
I6K38_RS15745	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K38_RS15750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K38_RS15755	COG1115	amino acid carrier protein
I6K38_RS15770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K38_RS15780	COG0460	homoserine dehydrogenase
I6K38_RS15780	COG0527	aspartate kinase activity
I6K38_RS15790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K38_RS15800	COG0745	RESPONSE REGULATOR receiver
I6K38_RS15805	COG4452	Inner membrane protein CreD
I6K38_RS15810	COG2205	protein histidine kinase activity
I6K38_RS15815	COG0745	RESPONSE REGULATOR receiver
I6K38_RS15820	COG3045	CreA protein
I6K38_RS15825	COG2207	Transcriptional regulator
I6K38_RS15825	COG3708	Transcriptional regulator
I6K38_RS15845	COG0741	lytic transglycosylase activity
I6K38_RS15850	COG0488	(ABC) transporter
I6K38_RS15860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K38_RS15865	COG0560	Phosphoserine phosphatase
I6K38_RS15870	COG3726	membrane protein affecting hemolysin expression
I6K38_RS15900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K38_RS15905	COG0084	hydrolase, TatD family'
I6K38_RS15910	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K38_RS15915	COG5487	UPF0391 membrane protein
I6K38_RS15920	COG2823	Periplasmic or secreted lipoprotein
I6K38_RS15930	COG1011	Hydrolase
I6K38_RS15935	COG0456	acetyltransferase
I6K38_RS15940	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K38_RS15975	COG3706	GGDEF domain
I6K38_RS15980	COG4114	ferric iron reductase
I6K38_RS15985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS15985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS15990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K38_RS15995	COG2197	response regulator
I6K38_RS16000	COG2197	response regulator
I6K38_RS16015	COG2966	Psort location CytoplasmicMembrane, score
I6K38_RS16030	COG1484	DNA-dependent DNA replication
I6K38_RS16045	COG5464	transposase or invertase
I6K38_RS16055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K38_RS16060	COG3716	PTS system mannose fructose sorbose family IID component
I6K38_RS16065	COG3715	PTS system
I6K38_RS16080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K38_RS16080	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K38_RS16085	COG0456	acetyltransferase
I6K38_RS16085	COG1214	PFAM Peptidase M22, glycoprotease
I6K38_RS16095	COG1737	Transcriptional regulator
I6K38_RS16100	COG0800	Aldolase
I6K38_RS16105	COG3734	2-keto-3-deoxy-galactonokinase
I6K38_RS16120	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K38_RS16145	COG1846	Transcriptional regulator
I6K38_RS16155	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K38_RS16165	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS16170	COG3384	dioxygenase
I6K38_RS16180	COG3971	2-oxopent-4-enoate hydratase activity
I6K38_RS16200	COG2368	4-hydroxyphenylacetate
I6K38_RS16205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K38_RS16220	COG1966	Carbon starvation protein
I6K38_RS16225	COG2879	small protein
I6K38_RS16230	COG0523	cobalamin synthesis protein
I6K38_RS16240	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS16245	COG5464	transposase or invertase
I6K38_RS16250	COG1917	Cupin 2, conserved barrel domain protein
I6K38_RS16250	COG2207	Transcriptional regulator
I6K38_RS16260	COG2733	membrane
I6K38_RS16275	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K38_RS16280	COG1924	4 iron, 4 sulfur cluster binding
I6K38_RS16295	COG1566	PFAM secretion protein HlyD family protein
I6K38_RS16305	COG5457	Domain of unknown function (DUF1127)
I6K38_RS16310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K38_RS16320	COG0583	DNA-binding transcription factor activity
I6K38_RS16325	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K38_RS16335	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS16340	COG1129	ABC transporter
I6K38_RS16345	COG1879	ABC-type sugar transport system periplasmic component
I6K38_RS16355	COG3706	GGDEF domain
I6K38_RS16360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS16365	COG0842	Transport permease protein
I6K38_RS16365	COG1129	ABC transporter
I6K38_RS16370	COG0842	Transport permease protein
I6K38_RS16400	COG2850	peptidyl-arginine hydroxylation
I6K38_RS16415	COG5002	protein histidine kinase activity
I6K38_RS16420	COG0745	RESPONSE REGULATOR receiver
I6K38_RS16425	COG1538	Outer membrane efflux protein
I6K38_RS16430	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS16435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS16440	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K38_RS16450	COG3040	lipid binding
I6K38_RS16455	COG0789	Transcriptional regulator
I6K38_RS16460	COG3631	Ketosteroid isomerase-related protein
I6K38_RS16465	COG0300	oxidoreductase activity
I6K38_RS16480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K38_RS16500	COG3272	Protein of unknown function (DUF1722)
I6K38_RS16505	COG4580	involved in the transport of maltose and maltodextrins
I6K38_RS16510	COG2115	Belongs to the xylose isomerase family
I6K38_RS16515	COG2211	Major facilitator Superfamily
I6K38_RS16520	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K38_RS16540	COG1216	Glycosyl transferase, family 2
I6K38_RS16590	COG1715	Restriction endonuclease
I6K38_RS16595	COG1196	nuclear chromosome segregation
I6K38_RS16615	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6K38_RS16620	COG0582	viral genome integration into host DNA
I6K38_RS16630	COG0288	reversible hydration of carbon dioxide
I6K38_RS16635	COG0659	secondary active sulfate transmembrane transporter activity
I6K38_RS16640	COG1064	alcohol dehydrogenase
I6K38_RS16645	COG1175	transmembrane transport
I6K38_RS16650	COG0395	ABC-type sugar transport system, permease component
I6K38_RS16655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K38_RS16660	COG3842	ATPase activity
I6K38_RS16675	COG1082	Xylose isomerase domain protein TIM barrel
I6K38_RS16685	COG3962	Belongs to the TPP enzyme family
I6K38_RS16690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K38_RS16695	COG0837	glucose binding
I6K38_RS16695	COG1737	Transcriptional regulator
I6K38_RS16700	COG3718	enzyme involved in inositol metabolism
I6K38_RS16715	COG0433	COG0433 Predicted ATPase
I6K38_RS16720	COG0795	lipopolysaccharide-transporting ATPase activity
I6K38_RS16725	COG0795	lipopolysaccharide-transporting ATPase activity
I6K38_RS16735	COG2927	DNA polymerase III (CHI subunit)
I6K38_RS16740	COG0525	valine-tRNA ligase activity
I6K38_RS16765	COG2731	YhcH YjgK YiaL family protein
I6K38_RS16800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K38_RS16800	COG1263	PTS System
I6K38_RS16805	COG0366	Alpha amylase catalytic
I6K38_RS16810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS16815	COG1486	melibiose metabolic process
I6K38_RS16840	COG0602	queuosine metabolic process
I6K38_RS16845	COG2026	Addiction module toxin, RelE StbE family
I6K38_RS16850	COG3077	Addiction module antitoxin, RelB DinJ family
I6K38_RS16855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS16855	COG3711	transcriptional antiterminator
I6K38_RS16860	COG2706	6-phosphogluconolactonase activity
I6K38_RS16875	COG3964	amidohydrolase
I6K38_RS16915	COG0312	modulator of DNA gyrase
I6K38_RS16940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K38_RS16950	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS16955	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS16960	COG1129	ABC transporter
I6K38_RS16965	COG1879	ABC-type sugar transport system periplasmic component
I6K38_RS16980	COG2105	PFAM AIG2 family protein
I6K38_RS16985	COG2911	Protein conserved in bacteria
I6K38_RS16990	COG0729	surface antigen
I6K38_RS17000	COG1253	flavin adenine dinucleotide binding
I6K38_RS17025	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K38_RS17040	COG1733	regulation of RNA biosynthetic process
I6K38_RS17045	COG0702	epimerase
I6K38_RS17055	COG0697	spore germination
I6K38_RS17065	COG1113	amino acid transport
I6K38_RS17070	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K38_RS17075	COG3061	Opacity-associated protein A
I6K38_RS17085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K38_RS17090	COG2965	DNA replication, synthesis of RNA primer
I6K38_RS17150	COG1073	alpha beta
I6K38_RS17155	COG3650	response to hydrogen peroxide
I6K38_RS17165	COG1960	acyl-CoA dehydrogenase activity
I6K38_RS17170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K38_RS17175	COG0557	exoribonuclease II activity
I6K38_RS17190	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K38_RS17200	COG0330	HflC and HflK could
I6K38_RS17205	COG0330	HflC and HflK could
I6K38_RS17210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K38_RS17230	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K38_RS17235	COG0802	atpase or kinase
I6K38_RS17240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K38_RS17240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K38_RS17245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K38_RS17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS17285	COG3264	Mechanosensitive ion channel
I6K38_RS17285	COG1511	domain protein
I6K38_RS17300	COG1053	succinate dehydrogenase
I6K38_RS17305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K38_RS17325	COG2076	Multidrug Resistance protein
I6K38_RS17330	COG5510	response to toxic substance
I6K38_RS17345	COG1509	lysine 2,3-aminomutase activity
I6K38_RS17410	COG0531	amino acid
I6K38_RS17415	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K38_RS17420	COG1027	Aspartate ammonia-lyase
I6K38_RS17425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K38_RS17440	COG1309	transcriptional regulator
I6K38_RS17470	COG0457	Tetratricopeptide repeat
I6K38_RS17475	COG0726	polysaccharide deacetylase
I6K38_RS17475	COG1649	PFAM Uncharacterised BCR, COG1649
I6K38_RS17480	COG1215	transferase activity, transferring glycosyl groups
I6K38_RS17495	COG0861	Integral membrane protein TerC family
I6K38_RS17535	COG1486	melibiose metabolic process
I6K38_RS17540	COG2169	Transcriptional regulator
I6K38_RS17550	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K38_RS17555	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K38_RS17560	COG2188	Transcriptional regulator
I6K38_RS17565	COG3624	Phosphonate C-P lyase system protein PhnG
I6K38_RS17570	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K38_RS17575	COG3626	phosphonate metabolism
I6K38_RS17580	COG3627	carbon phosphorus lyase activity
I6K38_RS17585	COG4107	phosphonate C-P lyase system protein PhnK
I6K38_RS17590	COG4778	phosphonate C-P lyase system protein PhnL
I6K38_RS17595	COG3454	Phosphonate metabolism
I6K38_RS17605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K38_RS17615	COG0784	Response regulator, receiver
I6K38_RS17615	COG4191	Histidine kinase
I6K38_RS17620	COG1129	ABC transporter
I6K38_RS17625	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS17660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K38_RS17665	COG1301	dicarboxylic acid transport
I6K38_RS17675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K38_RS17680	COG3162	membrane
I6K38_RS17710	COG3539	Fimbrial protein
I6K38_RS17715	COG1346	cytolysis
I6K38_RS17720	COG1380	Effector of murein hydrolase LrgA
I6K38_RS17725	COG0583	DNA-binding transcription factor activity
I6K38_RS17730	COG0025	NhaP-type Na H and K H
I6K38_RS17735	COG2252	PERMEase
I6K38_RS17740	COG0625	glutathione transferase activity
I6K38_RS17745	COG0789	Transcriptional regulator
I6K38_RS17755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K38_RS17785	COG1234	tRNA 3'-trailer cleavage
I6K38_RS17790	COG1609	Transcriptional regulator
I6K38_RS17795	COG0483	inositol monophosphate 1-phosphatase activity
I6K38_RS17805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K38_RS17825	COG4771	TonB-dependent receptor
I6K38_RS17830	COG0741	lytic transglycosylase activity
I6K38_RS17845	COG2315	Protein conserved in bacteria
I6K38_RS17850	COG0432	Pfam Uncharacterised protein family UPF0047
I6K38_RS17865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K38_RS17870	COG0305	Participates in initiation and elongation during chromosome replication
I6K38_RS17885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K38_RS17895	COG0735	belongs to the Fur family
I6K38_RS17900	COG3237	CsbD-like
I6K38_RS17910	COG0534	Mate efflux family protein
I6K38_RS17920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K38_RS17990	COG0251	oxidation-reduction process
I6K38_RS18000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K38_RS18010	COG0527	aspartate kinase activity
I6K38_RS18060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K38_RS18070	COG0456	acetyltransferase
I6K38_RS18100	COG0151	Belongs to the GarS family
I6K38_RS18110	COG4191	Histidine kinase
I6K38_RS18115	COG3678	ATP-independent chaperone mediated protein folding
I6K38_RS18150	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K38_RS18165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K38_RS18170	COG2104	thiamine diphosphate biosynthetic process
I6K38_RS18185	COG3706	GGDEF domain
I6K38_RS18195	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K38_RS18200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K38_RS18235	COG0250	Participates in transcription elongation, termination and antitermination
I6K38_RS18280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K38_RS18310	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K38_RS18320	COG1739	Uncharacterized protein family UPF0029
I6K38_RS18360	COG0805	protein transport
I6K38_RS18380	COG3165	ubiquinone biosynthetic process from chorismate
I6K38_RS18410	COG0583	DNA-binding transcription factor activity
I6K38_RS18415	COG0697	spore germination
I6K38_RS18420	COG0561	phosphatase activity
I6K38_RS18425	COG2267	carboxylic ester hydrolase activity
I6K38_RS18430	COG1280	lysine exporter protein (LysE YggA)
I6K38_RS18440	COG1280	lysine exporter protein (LysE YggA)
I6K38_RS18470	COG0210	DNA helicase
I6K38_RS18475	COG1011	Hydrolase
I6K38_RS18505	COG3072	Adenylate cyclase
I6K38_RS18520	COG2959	enzyme of heme biosynthesis
I6K38_RS18525	COG3071	HemY protein
I6K38_RS18570	COG2244	polysaccharide biosynthetic process
I6K38_RS18575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K38_RS18580	COG0456	acetyltransferase
I6K38_RS18585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K38_RS18590	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K38_RS18595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K38_RS18600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K38_RS18610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K38_RS18615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K38_RS18620	COG3118	belongs to the thioredoxin family
I6K38_RS18645	COG1811	Na channel or pump
I6K38_RS18655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K38_RS18660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K38_RS18670	COG0583	DNA-binding transcription factor activity
I6K38_RS18675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K38_RS18690	COG3978	acetolactate synthase activity
I6K38_RS18715	COG3085	chromosome segregation
I6K38_RS18790	COG0583	DNA-binding transcription factor activity
I6K38_RS18805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K38_RS18820	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K38_RS18825	COG2207	Transcriptional regulator
I6K38_RS18835	COG0371	Dehydrogenase
I6K38_RS18840	COG0697	spore germination
I6K38_RS18850	COG0583	DNA-binding transcription factor activity
I6K38_RS18860	COG0737	Belongs to the 5'-nucleotidase family
I6K38_RS18870	COG0460	homoserine dehydrogenase
I6K38_RS18870	COG0527	aspartate kinase activity
I6K38_RS18875	COG0626	cystathionine gamma-synthase activity
I6K38_RS18890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K38_RS18895	COG1609	Transcriptional regulator
I6K38_RS18900	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K38_RS18915	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K38_RS18935	COG3678	ATP-independent chaperone mediated protein folding
I6K38_RS18940	COG0745	RESPONSE REGULATOR receiver
I6K38_RS18945	COG2205	protein histidine kinase activity
I6K38_RS18950	COG2258	MOSC domain
I6K38_RS18955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K38_RS18995	COG1129	ABC transporter
I6K38_RS19000	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS19005	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS19010	COG1454	alcohol dehydrogenase
I6K38_RS19020	COG2211	Major facilitator Superfamily
I6K38_RS19065	COG0437	4 iron, 4 sulfur cluster binding
I6K38_RS19070	COG2864	formate dehydrogenase
I6K38_RS19085	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K38_RS19095	COG0456	acetyltransferase
I6K38_RS19110	COG1011	Hydrolase
I6K38_RS19125	COG3852	Histidine kinase
I6K38_RS19140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K38_RS19160	COG0204	Acyl-transferase
I6K38_RS19170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K38_RS19175	COG3084	Protein conserved in bacteria
I6K38_RS19185	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K38_RS19210	COG2186	Transcriptional regulator
I6K38_RS19215	COG0477	Major facilitator Superfamily
I6K38_RS19220	COG1609	Transcriptional regulator
I6K38_RS19225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K38_RS19235	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS19240	COG1129	ABC transporter
I6K38_RS19270	COG1522	sequence-specific DNA binding
I6K38_RS19275	COG0716	FMN binding
I6K38_RS19290	COG3312	ion transport
I6K38_RS19340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K38_RS19345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K38_RS19350	COG0573	inorganic phosphate transmembrane transporter activity
I6K38_RS19355	COG0581	inorganic phosphate transmembrane transporter activity
I6K38_RS19360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K38_RS19365	COG0704	Plays a role in the regulation of phosphate uptake
I6K38_RS19375	COG2382	esterase
I6K38_RS19380	COG0363	glucosamine-6-phosphate deaminase activity
I6K38_RS19385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K38_RS19390	COG2252	PERMEase
I6K38_RS19395	COG0431	NADPH-dependent FMN reductase
I6K38_RS19400	COG2091	lysine biosynthetic process via aminoadipic acid
I6K38_RS19430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K38_RS19460	COG0187	DNA topoisomerase II activity
I6K38_RS19465	COG0561	phosphatase activity
I6K38_RS19480	COG2186	Transcriptional regulator
I6K38_RS19485	COG3734	2-keto-3-deoxy-galactonokinase
I6K38_RS19490	COG0800	Aldolase
I6K38_RS19500	COG2271	Major facilitator Superfamily
I6K38_RS19505	COG0823	Involved in the tonB-independent uptake of proteins
I6K38_RS19510	COG5645	(Lipo)protein
I6K38_RS19525	COG3645	SOS response
I6K38_RS19535	COG2188	Transcriptional regulator
I6K38_RS19550	COG2149	membrane
I6K38_RS19570	COG2610	gluconate transmembrane transporter activity
I6K38_RS19580	COG0583	DNA-binding transcription factor activity
I6K38_RS19585	COG2814	Major facilitator Superfamily
I6K38_RS19615	COG0028	Belongs to the TPP enzyme family
I6K38_RS19620	COG0440	acetolactate synthase activity
I6K38_RS19625	COG2197	response regulator
I6K38_RS19635	COG2271	Major facilitator Superfamily
I6K38_RS19675	COG2188	Transcriptional regulator
I6K38_RS19700	COG4580	involved in the transport of maltose and maltodextrins
I6K38_RS19705	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K38_RS19710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS19710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS19720	COG1609	Transcriptional regulator
I6K38_RS19735	COG0583	DNA-binding transcription factor activity
I6K38_RS19740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K38_RS19745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K38_RS19750	COG2828	Protein conserved in bacteria
I6K38_RS19765	COG0697	spore germination
I6K38_RS19770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K38_RS19770	COG1263	PTS System
I6K38_RS19780	COG2814	Major facilitator Superfamily
I6K38_RS19790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K38_RS19825	COG0583	DNA-binding transcription factor activity
I6K38_RS19850	COG1464	Belongs to the NlpA lipoprotein family
I6K38_RS19865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K38_RS19875	COG1064	alcohol dehydrogenase
I6K38_RS19905	COG2211	Major facilitator Superfamily
I6K38_RS19910	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K38_RS19920	COG1486	melibiose metabolic process
I6K38_RS19925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K38_RS19925	COG1263	PTS System
I6K38_RS19930	COG2982	Protein involved in outer membrane biogenesis
I6K38_RS19935	COG2233	PERMEase
I6K38_RS19940	COG0786	glutamate:sodium symporter activity
I6K38_RS19960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K38_RS19985	COG3152	Membrane
I6K38_RS19995	COG1494	fructose-1,6-bisphosphatase
I6K38_RS20000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K38_RS20005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K38_RS20010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K38_RS20030	COG2860	membrane
I6K38_RS20040	COG2169	Transcriptional regulator
I6K38_RS20040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K38_RS20045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K38_RS20050	COG1561	YicC-like family, N-terminal region
I6K38_RS20070	COG1131	(ABC) transporter
I6K38_RS20075	COG0842	Transport permease protein
I6K38_RS20105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K38_RS20140	COG1519	Transferase
I6K38_RS20145	COG1216	Glycosyl transferase, family 2
I6K38_RS20150	COG0438	transferase activity, transferring glycosyl groups
I6K38_RS20160	COG0859	PFAM glycosyl transferase family 9
I6K38_RS20185	COG0859	PFAM glycosyl transferase family 9
I6K38_RS20200	COG0156	8-amino-7-oxononanoate synthase activity
I6K38_RS20210	COG0463	Glycosyl transferase, family 2
I6K38_RS20215	COG2861	carbohydrate metabolic process
I6K38_RS20220	COG4942	peptidase
I6K38_RS20230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K38_RS20235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K38_RS20255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K38_RS20265	COG2186	Transcriptional regulator
I6K38_RS20285	COG3722	fumarate hydratase activity
I6K38_RS20305	COG0625	glutathione transferase activity
I6K38_RS20315	COG3276	selenocysteine insertion sequence binding
I6K38_RS20320	COG1414	Transcriptional regulator
I6K38_RS20325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K38_RS20330	COG3977	Valine--pyruvate aminotransferase
I6K38_RS20335	COG0366	Alpha amylase catalytic
I6K38_RS20340	COG2992	FlgJ-related protein
I6K38_RS20345	COG1609	Transcriptional regulator
I6K38_RS20345	COG2207	Transcriptional regulator
I6K38_RS20350	COG4214	carbohydrate transport
I6K38_RS20360	COG4213	ABC transporter substrate-binding protein
I6K38_RS20375	COG4682	membrane
I6K38_RS20380	COG4682	membrane
I6K38_RS20385	COG3274	enterobacterial common antigen metabolic process
I6K38_RS20420	COG1278	Cold shock
I6K38_RS20425	COG2944	sequence-specific DNA binding
I6K38_RS20430	COG2814	Major facilitator Superfamily
I6K38_RS20450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K38_RS20460	COG1609	Transcriptional regulator
I6K38_RS20465	COG2885	chlorophyll binding
I6K38_RS20470	COG0243	molybdopterin cofactor binding
I6K38_RS20475	COG0456	acetyltransferase
I6K38_RS20480	COG2818	Glycosylase
I6K38_RS20485	COG5571	outer membrane autotransporter
I6K38_RS20490	COG2223	nitrite transmembrane transporter activity
I6K38_RS20510	COG0747	negative chemotaxis
I6K38_RS20515	COG0601	transmembrane transport
I6K38_RS20520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS20525	COG0444	Belongs to the ABC transporter superfamily
I6K38_RS20530	COG4608	Belongs to the ABC transporter superfamily
I6K38_RS20545	COG2894	cell division
I6K38_RS20555	COG1215	transferase activity, transferring glycosyl groups
I6K38_RS20560	COG0457	Tetratricopeptide repeat
I6K38_RS20575	COG2194	sulfuric ester hydrolase activity
I6K38_RS20605	COG1215	transferase activity, transferring glycosyl groups
I6K38_RS20610	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K38_RS20615	COG3118	belongs to the thioredoxin family
I6K38_RS20615	COG0457	Tetratricopeptide repeat
I6K38_RS20620	COG2200	EAL domain
I6K38_RS20620	COG2199	diguanylate cyclase activity
I6K38_RS20630	COG0612	Peptidase, M16
I6K38_RS20640	COG2982	Protein involved in outer membrane biogenesis
I6K38_RS20645	COG0477	Major facilitator Superfamily
I6K38_RS20650	COG1295	ribonuclease BN
I6K38_RS20655	COG0583	DNA-binding transcription factor activity
I6K38_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS20665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K38_RS20675	COG1454	alcohol dehydrogenase
I6K38_RS20685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K38_RS20690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K38_RS20695	COG0671	phosphoesterase, PA-phosphatase related
I6K38_RS20715	COG0589	response to stress
I6K38_RS20725	COG0306	phosphate transporter
I6K38_RS20730	COG2081	HI0933 family
I6K38_RS20735	COG2239	Acts as a magnesium transporter
I6K38_RS20750	COG1124	(ABC) transporter
I6K38_RS20760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS20765	COG0601	transmembrane transport
I6K38_RS20770	COG0747	negative chemotaxis
I6K38_RS20780	COG3479	Phenolic acid decarboxylase
I6K38_RS20820	COG0628	permease
I6K38_RS20825	COG0477	Major facilitator Superfamily
I6K38_RS20835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K38_RS20850	COG3714	YhhN family
I6K38_RS20860	COG3776	membrane
I6K38_RS20865	COG0742	ribosomal rna small subunit methyltransferase
I6K38_RS20870	COG0552	protein localization to endoplasmic reticulum
I6K38_RS20875	COG2884	Cell division ATP-binding protein ftsE
I6K38_RS20880	COG2177	Part of the ABC transporter FtsEX involved in
I6K38_RS20895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K38_RS20910	COG0683	leucine binding
I6K38_RS20920	COG0683	leucine binding
I6K38_RS20925	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K38_RS20975	COG0584	glycerophosphoryl diester phosphodiesterase
I6K38_RS20985	COG0405	Gamma-glutamyltransferase
I6K38_RS20990	COG1247	-acetyltransferase
I6K38_RS21000	COG0673	inositol 2-dehydrogenase activity
I6K38_RS21005	COG1741	Belongs to the pirin family
I6K38_RS21010	COG1609	Transcriptional regulator
I6K38_RS21015	COG3265	gluconokinase activity
I6K38_RS21020	COG2610	gluconate transmembrane transporter activity
I6K38_RS21030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K38_RS21055	COG0058	SHG alpha-glucan phosphorylase activity
I6K38_RS21060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K38_RS21075	COG1349	DNA-binding transcription factor activity
I6K38_RS21085	COG0058	SHG alpha-glucan phosphorylase activity
I6K38_RS21090	COG1640	4-alpha-glucanotransferase
I6K38_RS21095	COG2610	gluconate transmembrane transporter activity
I6K38_RS21105	COG1040	competence protein
I6K38_RS21130	COG1918	ferrous iron import across plasma membrane
I6K38_RS21135	COG2183	response to ionizing radiation
I6K38_RS21140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K38_RS21165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K38_RS21170	COG1011	Hydrolase
I6K38_RS21180	COG0494	nUDIX hydrolase
I6K38_RS21185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K38_RS21210	COG4796	Type ii and iii secretion system protein
I6K38_RS21225	COG3266	domain, Protein
I6K38_RS21230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K38_RS21235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K38_RS21260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K38_RS21265	COG0402	S-adenosylhomocysteine deaminase activity
I6K38_RS21270	COG0738	Major facilitator superfamily
I6K38_RS21295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K38_RS21300	COG1289	transmembrane transporter activity
I6K38_RS21310	COG1765	OsmC-like protein
I6K38_RS21315	COG3954	Phosphoribulokinase
I6K38_RS21325	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K38_RS21330	COG0488	(ABC) transporter
I6K38_RS21345	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K38_RS21350	COG1047	Peptidyl-prolyl cis-trans
I6K38_RS21360	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K38_RS21365	COG2964	Protein conserved in bacteria
I6K38_RS21420	COG0051	transcription antitermination factor activity, RNA binding
I6K38_RS21445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K38_RS21460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K38_RS21525	COG0201	protein transport
I6K38_RS21550	COG0202	RNA polymerase activity
I6K38_RS21565	COG0789	Transcriptional regulator
I6K38_RS21570	COG3036	rescue of stalled ribosome
I6K38_RS21600	COG0758	DNA mediated transformation
I6K38_RS21610	COG0551	DNA topoisomerase type I activity
I6K38_RS21630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K38_RS21665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K38_RS21670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS21675	COG1309	transcriptional regulator
I6K38_RS21695	COG4145	pantothenate transmembrane transporter activity
I6K38_RS21700	COG3924	membrane
I6K38_RS21705	COG0439	Biotin carboxylase
I6K38_RS21710	COG0511	ligase activity, forming carbon-carbon bonds
I6K38_RS21735	COG2199	diguanylate cyclase activity
I6K38_RS21735	COG2200	EAL domain
I6K38_RS21740	COG1077	Cell shape determining protein MreB Mrl
I6K38_RS21745	COG1792	Involved in formation and maintenance of cell shape
I6K38_RS21750	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K38_RS21760	COG1530	ribonuclease E activity
I6K38_RS21765	COG3164	Protein of unknown function
I6K38_RS21770	COG0312	modulator of DNA gyrase
I6K38_RS21775	COG0583	DNA-binding transcription factor activity
I6K38_RS21790	COG1289	transmembrane transporter activity
I6K38_RS21795	COG2732	(Barnase) inhibitor
I6K38_RS21830	COG0471	metal ion transport
I6K38_RS21835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K38_RS21840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K38_RS21865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K38_RS21870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K38_RS21875	COG3105	Protein conserved in bacteria
I6K38_RS21880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K38_RS21900	COG0625	glutathione transferase activity
I6K38_RS21905	COG2969	positive regulation of protein catabolic process
I6K38_RS21915	COG0493	'glutamate synthase
I6K38_RS21920	COG0070	glutamate synthase
I6K38_RS21920	COG0069	glutamate synthase activity
I6K38_RS21920	COG0067	glutamate synthase
I6K38_RS21925	COG1242	4 iron, 4 sulfur cluster binding
I6K38_RS21930	COG2271	Major facilitator Superfamily
I6K38_RS21935	COG1063	alcohol dehydrogenase
I6K38_RS21940	COG1312	Catalyzes the dehydration of D-mannonate
I6K38_RS21945	COG2198	Histidine kinase
I6K38_RS21945	COG5002	protein histidine kinase activity
I6K38_RS21945	COG0784	Response regulator, receiver
I6K38_RS21950	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K38_RS21955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K38_RS21960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS21970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS21975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K38_RS21980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K38_RS21985	COG1137	ATPase activity
I6K38_RS21990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K38_RS21995	COG3117	lipopolysaccharide transmembrane transporter activity
I6K38_RS22000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K38_RS22010	COG0530	calcium, potassium:sodium antiporter activity
I6K38_RS22015	COG1127	ABC transporter
I6K38_RS22020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K38_RS22025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K38_RS22030	COG2854	intermembrane phospholipid transfer
I6K38_RS22035	COG3113	response to antibiotic
I6K38_RS22040	COG5007	Belongs to the BolA IbaG family
I6K38_RS22050	COG3423	Transcriptional regulator
I6K38_RS22055	COG0142	geranyltranstransferase activity
I6K38_RS22070	COG0697	spore germination
I6K38_RS22080	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K38_RS22090	COG1534	Rna-binding protein
I6K38_RS22100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K38_RS22105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K38_RS22115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K38_RS22155	COG0195	Participates in both transcription termination and antitermination
I6K38_RS22200	COG0814	amino acid
I6K38_RS22205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K38_RS22210	COG0826	peptidase U32
I6K38_RS22215	COG0826	peptidase U32
I6K38_RS22220	COG3154	lipid carrier protein
I6K38_RS22225	COG3153	acetyltransferase
I6K38_RS22240	COG0693	protein deglycase activity
I6K38_RS22245	COG0702	epimerase
I6K38_RS22250	COG0701	Predicted permease
I6K38_RS22255	COG2823	Periplasmic or secreted lipoprotein
I6K38_RS22275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K38_RS22280	COG2721	sulfolactate sulfo-lyase activity
I6K38_RS22285	COG2271	Major facilitator Superfamily
I6K38_RS22295	COG2084	Dehydrogenase
I6K38_RS22300	COG1929	Belongs to the glycerate kinase type-1 family
I6K38_RS22325	COG1741	Belongs to the pirin family
I6K38_RS22330	COG0583	DNA-binding transcription factor activity
I6K38_RS22335	COG3152	Membrane
I6K38_RS22340	COG0435	Glutathione S-transferase
I6K38_RS22345	COG2259	Doxx family
I6K38_RS22355	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K38_RS22360	COG4575	ribosome binding
I6K38_RS22365	COG1422	Protein of unknown function (DUF1090)
I6K38_RS22375	COG0586	Pfam SNARE associated Golgi protein
I6K38_RS22380	COG2186	Transcriptional regulator
I6K38_RS22385	COG2271	Major facilitator Superfamily
I6K38_RS22395	COG2721	sulfolactate sulfo-lyase activity
I6K38_RS22410	COG0861	Integral membrane protein TerC family
I6K38_RS22415	COG0673	inositol 2-dehydrogenase activity
I6K38_RS22420	COG1451	nucleotide metabolic process
I6K38_RS22440	COG1902	pentaerythritol trinitrate reductase activity
I6K38_RS22440	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K38_RS22490	COG1695	Transcriptional regulator
I6K38_RS22495	COG2375	cellular response to nickel ion
I6K38_RS22510	COG1461	Dihydroxyacetone kinase
I6K38_RS22515	COG2376	Dihydroxyacetone kinase
I6K38_RS22585	COG3247	response to pH
I6K38_RS22595	COG2205	protein histidine kinase activity
I6K38_RS22595	COG2198	Histidine kinase
I6K38_RS22595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS22595	COG0784	Response regulator, receiver
I6K38_RS22600	COG2197	response regulator
I6K38_RS22625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K38_RS22630	COG0358	DNA primase activity
I6K38_RS22635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K38_RS22700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K38_RS22715	COG4991	sh3 domain protein
I6K38_RS22720	COG3025	triphosphatase activity
I6K38_RS22745	COG2960	long-chain fatty acid transporting porin activity
I6K38_RS22760	COG3384	dioxygenase
I6K38_RS22765	COG0754	glutathionylspermidine amidase activity
I6K38_RS22780	COG0494	nUDIX hydrolase
I6K38_RS22785	COG3151	Protein conserved in bacteria
I6K38_RS22790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K38_RS22795	COG3150	esterase
I6K38_RS22805	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K38_RS22810	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K38_RS22815	COG0642	Histidine kinase
I6K38_RS22825	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K38_RS22830	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K38_RS22835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K38_RS22840	COG0204	Acyl-transferase
I6K38_RS22845	COG2132	Multicopper oxidase
I6K38_RS22850	COG1032	radical SAM domain protein
I6K38_RS22860	COG0656	L-ascorbic acid biosynthetic process
I6K38_RS22865	COG1979	alcohol dehydrogenase
I6K38_RS22870	COG2207	Transcriptional regulator
I6K38_RS22875	COG0586	Pfam SNARE associated Golgi protein
I6K38_RS22880	COG0626	cystathionine gamma-synthase activity
I6K38_RS22890	COG0848	biopolymer transport protein
I6K38_RS22895	COG2211	Major facilitator Superfamily
I6K38_RS22920	COG0625	glutathione transferase activity
I6K38_RS22935	COG0754	glutathionylspermidine amidase activity
I6K38_RS22940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K38_RS22960	COG0583	DNA-binding transcription factor activity
I6K38_RS22965	COG0626	cystathionine gamma-synthase activity
I6K38_RS22980	COG3121	Chaperone
I6K38_RS22995	COG3121	Chaperone
I6K38_RS23000	COG3121	Chaperone
I6K38_RS23005	COG3188	usher protein
I6K38_RS23030	COG1811	Na channel or pump
I6K38_RS23035	COG1982	Orn Lys Arg decarboxylase major
I6K38_RS23040	COG2211	Major facilitator Superfamily
I6K38_RS23055	COG1194	a g-specific adenine glycosylase
I6K38_RS23065	COG3171	Protein conserved in bacteria
I6K38_RS23075	COG4214	carbohydrate transport
I6K38_RS23090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K38_RS23105	COG0762	integral membrane protein
I6K38_RS23110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K38_RS23115	COG2805	Type II/IV secretion system protein
I6K38_RS23135	COG0189	ligase activity
I6K38_RS23140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K38_RS23145	COG2356	endonuclease I
I6K38_RS23155	COG2814	Major facilitator Superfamily
I6K38_RS23190	COG0501	Belongs to the peptidase M48B family
I6K38_RS23195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K38_RS23210	COG0191	fructose-bisphosphate aldolase activity
I6K38_RS23215	COG0668	transmembrane transport
I6K38_RS23225	COG2968	Membrane
I6K38_RS23240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K38_RS23245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K38_RS23265	COG0006	proline dipeptidase activity
I6K38_RS23270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K38_RS23275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K38_RS23295	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS23300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K38_RS23320	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS23325	COG1737	Transcriptional regulator
I6K38_RS23335	COG1272	protein, Hemolysin III
I6K38_RS23345	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K38_RS23355	COG0716	FMN binding
I6K38_RS23360	COG4974	Belongs to the 'phage' integrase family
I6K38_RS23370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K38_RS23390	COG1811	Na channel or pump
I6K38_RS23400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K38_RS23405	COG0583	DNA-binding transcription factor activity
I6K38_RS23410	COG4942	peptidase
I6K38_RS23420	COG2814	Major facilitator Superfamily
I6K38_RS23435	COG0667	Aldo Keto reductase
I6K38_RS23475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K38_RS23480	COG1393	Belongs to the ArsC family
I6K38_RS23495	COG1538	Outer membrane efflux protein
I6K38_RS23500	COG1289	transmembrane transporter activity
I6K38_RS23515	COG3592	Divergent 4Fe-4S mono-cluster
I6K38_RS23520	COG2388	GCN5-related N-acetyl-transferase
I6K38_RS23530	COG3539	Fimbrial protein
I6K38_RS23535	COG3539	Fimbrial protein
I6K38_RS23540	COG3539	Fimbrial protein
I6K38_RS23545	COG3188	usher protein
I6K38_RS23550	COG3121	Chaperone
I6K38_RS23555	COG3539	Fimbrial protein
I6K38_RS23565	COG4974	Belongs to the 'phage' integrase family
I6K38_RS23570	COG0582	viral genome integration into host DNA
I6K38_RS23575	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K38_RS23580	COG1846	Transcriptional regulator
I6K38_RS23585	COG0697	spore germination
I6K38_RS23635	COG0667	Aldo Keto reductase
I6K38_RS23640	COG0814	amino acid
I6K38_RS23655	COG0183	Belongs to the thiolase family
I6K38_RS23665	COG0823	Involved in the tonB-independent uptake of proteins
I6K38_RS23670	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS23675	COG2814	Major facilitator Superfamily
I6K38_RS23710	COG3842	ATPase activity
I6K38_RS23715	COG0395	ABC-type sugar transport system, permease component
I6K38_RS23720	COG1175	transmembrane transport
I6K38_RS23725	COG1917	Cupin 2, conserved barrel domain protein
I6K38_RS23730	COG1794	racemase activity, acting on amino acids and derivatives
I6K38_RS23735	COG0583	DNA-binding transcription factor activity
I6K38_RS23745	COG1609	Transcriptional regulator
I6K38_RS23750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS23755	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS23760	COG2186	Transcriptional regulator
I6K38_RS23770	COG1609	Transcriptional regulator
I6K38_RS23790	COG0667	Aldo Keto reductase
I6K38_RS23800	COG0861	Integral membrane protein TerC family
I6K38_RS23835	COG2165	general secretion pathway protein
I6K38_RS23840	COG4795	General secretion pathway protein
I6K38_RS23850	COG4967	type IV pilus modification protein PilV
I6K38_RS23855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K38_RS23860	COG1025	Belongs to the peptidase M16 family
I6K38_RS23865	COG1074	ATP-dependent DNA helicase activity
I6K38_RS23870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K38_RS23880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K38_RS23880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K38_RS23885	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K38_RS23890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K38_RS23920	COG4656	Part of a membrane complex involved in electron transport
I6K38_RS23925	COG1454	alcohol dehydrogenase
I6K38_RS23925	COG1012	belongs to the aldehyde dehydrogenase family
I6K38_RS23955	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K38_RS24160	COG2885	chlorophyll binding
I6K38_RS24190	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K38_RS24195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K38_RS24200	COG2166	iron-sulfur cluster assembly
I6K38_RS24205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K38_RS24215	COG0583	DNA-binding transcription factor activity
I6K38_RS24220	COG2363	Small membrane protein
I6K38_RS24230	COG1349	DNA-binding transcription factor activity
I6K38_RS24250	COG0738	Major facilitator superfamily
I6K38_RS24255	COG0235	Class ii aldolase
I6K38_RS24260	COG1454	alcohol dehydrogenase
I6K38_RS24280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K38_RS24295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K38_RS24300	COG2011	ABC-type metal ion transport system permease component
I6K38_RS24305	COG1464	Belongs to the NlpA lipoprotein family
I6K38_RS24310	COG0477	Major facilitator Superfamily
I6K38_RS24320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K38_RS24325	COG1760	l-serine dehydratase
I6K38_RS24330	COG0814	amino acid
I6K38_RS24335	COG1611	Belongs to the LOG family
I6K38_RS24350	COG3098	single-species biofilm formation
I6K38_RS24355	COG0564	pseudouridine synthase activity
I6K38_RS24360	COG0716	FMN binding
I6K38_RS24365	COG2271	Major facilitator Superfamily
I6K38_RS24370	COG4948	Mandelate Racemase Muconate Lactonizing
I6K38_RS24375	COG4948	Mandelate Racemase Muconate Lactonizing
I6K38_RS24380	COG1929	Belongs to the glycerate kinase type-1 family
I6K38_RS24385	COG2205	protein histidine kinase activity
I6K38_RS24385	COG3437	response regulator, receiver
I6K38_RS24385	COG3850	Histidine kinase
I6K38_RS24385	COG4999	Histidine kinase
I6K38_RS24395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K38_RS24400	COG3956	TIGRFAM MazG family protein
I6K38_RS24420	COG0602	queuosine metabolic process
I6K38_RS24425	COG0720	synthase
I6K38_RS24445	COG2234	aminopeptidase activity
I6K38_RS24505	COG4942	peptidase
I6K38_RS24505	COG1388	LysM domain
I6K38_RS24510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K38_RS24535	COG0163	prenyltransferase activity
I6K38_RS24540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K38_RS24580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS24585	COG4558	Periplasmic binding protein
I6K38_RS24590	COG3720	iron ion transport
I6K38_RS24610	COG0679	Auxin Efflux Carrier
I6K38_RS24625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K38_RS24630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K38_RS24635	COG1121	(ABC) transporter
I6K38_RS24640	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K38_RS24645	COG1609	Transcriptional regulator
I6K38_RS24650	COG1940	carbohydrate kinase activity
I6K38_RS24655	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K38_RS24660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS24665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS24670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K38_RS24675	COG4580	involved in the transport of maltose and maltodextrins
I6K38_RS24685	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS24695	COG0309	Hydrogenase expression formation protein (HypE)
I6K38_RS24700	COG0409	Hydrogenase expression formation protein
I6K38_RS24705	COG0298	carbon dioxide binding
I6K38_RS24710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K38_RS24725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K38_RS24730	COG0651	ATP synthesis coupled electron transport
I6K38_RS24735	COG0650	Formate hydrogenlyase subunit 4
I6K38_RS24740	COG3261	NADH dehydrogenase
I6K38_RS24740	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K38_RS24745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K38_RS24750	COG3260	NADH ubiquinone oxidoreductase 20
I6K38_RS24760	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K38_RS24770	COG2723	6-phospho-beta-galactosidase activity
I6K38_RS24775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K38_RS24775	COG1263	PTS System
I6K38_RS24780	COG1609	Transcriptional regulator
I6K38_RS24785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K38_RS24790	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K38_RS24795	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K38_RS24820	COG1349	DNA-binding transcription factor activity
I6K38_RS24825	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K38_RS24830	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS24840	COG3732	PTS system glucitol sorbitol-specific
I6K38_RS24845	COG3730	PTS system glucitol sorbitol-specific
I6K38_RS24850	COG2951	lytic endotransglycosylase activity
I6K38_RS24855	COG1121	(ABC) transporter
I6K38_RS24860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K38_RS24870	COG1546	Belongs to the CinA family
I6K38_RS24890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K38_RS24920	COG2823	Periplasmic or secreted lipoprotein
I6K38_RS24925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K38_RS24930	COG1238	metal cluster binding
I6K38_RS24950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K38_RS24955	COG2814	Major facilitator Superfamily
I6K38_RS24960	COG1566	PFAM secretion protein HlyD family protein
I6K38_RS24965	COG1846	Transcriptional regulator
I6K38_RS24975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K38_RS24985	COG4176	ABC-type proline glycine betaine transport system permease component
I6K38_RS25000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K38_RS25010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K38_RS25015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K38_RS25020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K38_RS25025	COG4575	ribosome binding
I6K38_RS25040	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K38_RS25055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K38_RS25060	COG0640	Transcriptional regulator
I6K38_RS25070	COG0583	DNA-binding transcription factor activity
I6K38_RS25075	COG3284	Transcriptional regulator
I6K38_RS25085	COG3539	Fimbrial protein
I6K38_RS25090	COG3121	Chaperone
I6K38_RS25110	COG3188	usher protein
I6K38_RS25120	COG3539	Fimbrial protein
I6K38_RS25125	COG2197	response regulator
I6K38_RS25140	COG1028	Short-chain dehydrogenase reductase Sdr
I6K38_RS25150	COG0235	Class ii aldolase
I6K38_RS25160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS25195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS25200	COG2207	Transcriptional regulator
I6K38_RS25200	COG3708	Transcriptional regulator
I6K38_RS25225	COG1192	Involved in chromosome partitioning
I6K38_RS25260	COG2867	negative regulation of translational initiation
I6K38_RS25275	COG0497	DNA recombination
I6K38_RS25290	COG4536	flavin adenine dinucleotide binding
I6K38_RS25295	COG4137	Cytochrome C assembly protein
I6K38_RS25300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K38_RS25335	COG2885	chlorophyll binding
I6K38_RS25340	COG2199	diguanylate cyclase activity
I6K38_RS25350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K38_RS25355	COG1605	Chorismate mutase
I6K38_RS25355	COG0287	Prephenate dehydrogenase
I6K38_RS25365	COG1605	Chorismate mutase
I6K38_RS25365	COG0077	Prephenate dehydratase
I6K38_RS25375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K38_RS25380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K38_RS25395	COG0542	response to heat
I6K38_RS25420	COG0477	Major facilitator Superfamily
I6K38_RS25425	COG5544	Lipoprotein
I6K38_RS25430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K38_RS25440	COG3148	PFAM DTW domain containing protein
I6K38_RS25445	COG3118	belongs to the thioredoxin family
I6K38_RS25450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K38_RS25465	COG0513	Belongs to the DEAD box helicase family
I6K38_RS25475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K38_RS25490	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K38_RS25495	COG3026	antisigma factor binding
I6K38_RS25500	COG3086	response to oxidative stress
I6K38_RS25510	COG0681	Belongs to the peptidase S26 family
I6K38_RS25530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K38_RS25540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K38_RS25545	COG1737	Transcriptional regulator
I6K38_RS25550	COG0560	Phosphoserine phosphatase
I6K38_RS25565	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K38_RS25565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K38_RS25570	COG2205	protein histidine kinase activity
I6K38_RS25575	COG3170	Tfp pilus assembly protein FimV
I6K38_RS25580	COG2204	response regulator
I6K38_RS25585	COG0347	Belongs to the P(II) protein family
I6K38_RS25590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K38_RS25590	COG1017	nitric oxide dioxygenase activity
I6K38_RS25600	COG2259	Doxx family
I6K38_RS25605	COG1940	carbohydrate kinase activity
I6K38_RS25610	COG0457	Tetratricopeptide repeat
I6K38_RS25615	COG2814	Major facilitator Superfamily
I6K38_RS25615	COG0477	Major facilitator Superfamily
I6K38_RS25620	COG2017	converts alpha-aldose to the beta-anomer
I6K38_RS25625	COG2814	Major facilitator Superfamily
I6K38_RS25630	COG3711	transcriptional antiterminator
I6K38_RS25635	COG3683	transport system, periplasmic component
I6K38_RS25640	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K38_RS25670	COG0822	iron-sulfur transferase activity
I6K38_RS25690	COG0633	Ferredoxin
I6K38_RS25695	COG2975	iron-sulfur cluster assembly
I6K38_RS25715	COG2897	thiosulfate sulfurtransferase activity
I6K38_RS25720	COG2373	Large extracellular alpha-helical protein
I6K38_RS25725	COG4953	penicillin-binding protein 1C
I6K38_RS25755	COG2976	Protein conserved in bacteria
I6K38_RS25775	COG1645	bacterial-type flagellum-dependent swarming motility
I6K38_RS25785	COG0516	GMP reductase activity
I6K38_RS25785	COG0517	IMP dehydrogenase activity
I6K38_RS25795	COG3119	arylsulfatase activity
I6K38_RS25800	COG0641	radical SAM
I6K38_RS25820	COG2200	EAL domain
I6K38_RS25835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K38_RS25840	COG0683	leucine binding
I6K38_RS25845	COG2198	Histidine kinase
I6K38_RS25845	COG5002	protein histidine kinase activity
I6K38_RS25845	COG0784	Response regulator, receiver
I6K38_RS25850	COG0745	RESPONSE REGULATOR receiver
I6K38_RS25885	COG3436	PFAM IS66 Orf2 family protein
I6K38_RS25890	COG1120	ATPase activity
I6K38_RS25895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS25900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K38_RS25905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K38_RS25910	COG4772	TonB-dependent receptor
I6K38_RS25915	COG3712	iron ion homeostasis
I6K38_RS25920	COG1595	DNA-templated transcription, initiation
I6K38_RS25945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K38_RS25950	COG0601	transmembrane transport
I6K38_RS25965	COG4172	Belongs to the ABC transporter superfamily
I6K38_RS25990	COG1609	Transcriptional regulator
I6K38_RS26000	COG2223	nitrite transmembrane transporter activity
I6K38_RS26055	COG1126	abc transporter atp-binding protein
I6K38_RS26060	COG0765	amino acid transport
I6K38_RS26065	COG0765	amino acid transport
I6K38_RS26070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K38_RS26095	COG1609	Transcriptional regulator
I6K38_RS26100	COG2222	sugar isomerase
I6K38_RS26105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K38_RS26115	COG0765	amino acid transport
I6K38_RS26135	COG2801	Transposase and inactivated derivatives
I6K38_RS26140	COG3547	Transposase (IS116 IS110 IS902 family)
I6K38_RS26430	COG5499	transcription regulator containing HTH domain
I6K38_RS26605	COG1716	ATPase activity
I6K38_RS26605	COG5001	Diguanylate cyclase
I6K38_RS26630	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K38_RS26700	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K38_RS26730	COG0739	heme binding
I6K38_RS26740	COG2132	Multicopper oxidase
I6K38_RS26745	COG3667	copper resistance
I6K38_RS26750	COG2372	response to copper ion
I6K38_RS26755	COG1276	copper resistance
I6K38_RS26760	COG0745	RESPONSE REGULATOR receiver
I6K38_RS26765	COG2205	protein histidine kinase activity
I6K38_RS26835	COG0501	Belongs to the peptidase M48B family
I6K38_RS26850	COG0542	response to heat
I6K38_RS26855	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K38_RS26885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source