locus-tag	class	description
I6K52_RS00010	COG1175	transmembrane transport
I6K52_RS00040	COG4133	protoheme IX ABC transporter activity
I6K52_RS00045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K52_RS00050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K52_RS00065	COG1138	Cytochrome C-type biogenesis protein
I6K52_RS00070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K52_RS00075	COG4235	cytochrome complex assembly
I6K52_RS00075	COG3088	subunit of a heme lyase
I6K52_RS00095	COG5002	protein histidine kinase activity
I6K52_RS00095	COG3850	Histidine kinase
I6K52_RS00100	COG0745	RESPONSE REGULATOR receiver
I6K52_RS00115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K52_RS00145	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS00150	COG2610	gluconate transmembrane transporter activity
I6K52_RS00155	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K52_RS00165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K52_RS00175	COG0583	DNA-binding transcription factor activity
I6K52_RS00200	COG0277	FAD linked oxidase domain protein
I6K52_RS00205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K52_RS00230	COG0402	S-adenosylhomocysteine deaminase activity
I6K52_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS00270	COG0604	alcohol dehydrogenase
I6K52_RS00270	COG3321	synthase
I6K52_RS00300	COG4608	Belongs to the ABC transporter superfamily
I6K52_RS00305	COG0444	Belongs to the ABC transporter superfamily
I6K52_RS00330	COG0346	lactoylglutathione lyase activity
I6K52_RS00335	COG1349	DNA-binding transcription factor activity
I6K52_RS00370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K52_RS00420	COG0307	riboflavin synthase, alpha
I6K52_RS00425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K52_RS00430	COG2814	Major facilitator Superfamily
I6K52_RS00435	COG0583	DNA-binding transcription factor activity
I6K52_RS00450	COG2814	Major facilitator Superfamily
I6K52_RS00465	COG0791	NLP P60 protein
I6K52_RS00470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K52_RS00480	COG0346	lactoylglutathione lyase activity
I6K52_RS00485	COG1902	pentaerythritol trinitrate reductase activity
I6K52_RS00490	COG1309	transcriptional regulator
I6K52_RS00495	COG3313	Fe-S protein
I6K52_RS00500	COG4989	oxidoreductase activity
I6K52_RS00505	COG2032	superoxide dismutase activity
I6K52_RS00510	COG1289	transmembrane transporter activity
I6K52_RS00515	COG1566	PFAM secretion protein HlyD family protein
I6K52_RS00530	COG3706	GGDEF domain
I6K52_RS00545	COG3895	Periplasmic Protein
I6K52_RS00560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K52_RS00565	COG0625	glutathione transferase activity
I6K52_RS00575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K52_RS00585	COG4659	FMN binding
I6K52_RS00620	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS00630	COG0673	inositol 2-dehydrogenase activity
I6K52_RS00640	COG2814	Major facilitator Superfamily
I6K52_RS00660	COG3038	cytochrome b561
I6K52_RS00680	COG0583	DNA-binding transcription factor activity
I6K52_RS00685	COG3485	protocatechuate 3,4-dioxygenase
I6K52_RS00690	COG3485	protocatechuate 3,4-dioxygenase
I6K52_RS00695	COG5383	Protein conserved in bacteria
I6K52_RS00700	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K52_RS00715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K52_RS00720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K52_RS00725	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K52_RS00730	COG0500	methyltransferase
I6K52_RS00745	COG3708	Transcriptional regulator
I6K52_RS00745	COG2207	Transcriptional regulator
I6K52_RS00750	COG3135	benzoate transporter
I6K52_RS00755	COG1396	sequence-specific DNA binding
I6K52_RS00765	COG0826	peptidase U32
I6K52_RS00785	COG1294	oxidase, subunit
I6K52_RS00790	COG1271	oxidase subunit
I6K52_RS00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K52_RS00800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K52_RS00805	COG3842	ATPase activity
I6K52_RS00810	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K52_RS00815	COG1177	transmembrane transport
I6K52_RS00820	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS00855	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS00860	COG0747	negative chemotaxis
I6K52_RS00870	COG3238	Protein conserved in bacteria
I6K52_RS00875	COG1247	-acetyltransferase
I6K52_RS00885	COG2130	NADP-dependent
I6K52_RS00900	COG3691	Protein conserved in bacteria
I6K52_RS00905	COG1228	amidohydrolase
I6K52_RS00910	COG4772	TonB-dependent receptor
I6K52_RS00935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K52_RS00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K52_RS00945	COG1473	amidohydrolase
I6K52_RS00950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K52_RS00955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS00965	COG0765	amino acid transport
I6K52_RS00970	COG1126	abc transporter atp-binding protein
I6K52_RS00980	COG0625	glutathione transferase activity
I6K52_RS00990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K52_RS00995	COG3842	ATPase activity
I6K52_RS01000	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K52_RS01005	COG1178	ABC-type Fe3 transport system permease component
I6K52_RS01010	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K52_RS01015	COG2181	nitrate reductase activity
I6K52_RS01020	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K52_RS01025	COG1140	nitrate reductase beta subunit
I6K52_RS01030	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K52_RS01050	COG1414	Transcriptional regulator
I6K52_RS01055	COG4948	Mandelate Racemase Muconate Lactonizing
I6K52_RS01060	COG4829	muconolactone delta-isomerase
I6K52_RS01065	COG3485	protocatechuate 3,4-dioxygenase
I6K52_RS01075	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K52_RS01100	COG0437	4 iron, 4 sulfur cluster binding
I6K52_RS01105	COG2864	formate dehydrogenase
I6K52_RS01120	COG2326	polyphosphate kinase activity
I6K52_RS01130	COG2814	Major facilitator Superfamily
I6K52_RS01140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K52_RS01150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K52_RS01160	COG0747	negative chemotaxis
I6K52_RS01165	COG1064	alcohol dehydrogenase
I6K52_RS01180	COG0488	(ABC) transporter
I6K52_RS01220	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS01225	COG3729	General stress protein
I6K52_RS01235	COG3685	Protein conserved in bacteria
I6K52_RS01245	COG0366	Alpha amylase catalytic
I6K52_RS01255	COG2323	membrane
I6K52_RS01265	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K52_RS01275	COG1764	response to oxidative stress
I6K52_RS01300	COG3781	membrane
I6K52_RS01305	COG0243	molybdopterin cofactor binding
I6K52_RS01310	COG0583	DNA-binding transcription factor activity
I6K52_RS01315	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K52_RS01320	COG2814	Major facilitator Superfamily
I6K52_RS01325	COG1285	pathogenesis
I6K52_RS01330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K52_RS01340	COG0583	DNA-binding transcription factor activity
I6K52_RS01360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K52_RS01360	COG0519	Catalyzes the synthesis of GMP from XMP
I6K52_RS01400	COG0596	Alpha beta hydrolase
I6K52_RS01410	COG2205	protein histidine kinase activity
I6K52_RS01425	COG0076	glutamate decarboxylase activity
I6K52_RS01430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K52_RS01435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K52_RS01440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K52_RS01445	COG1116	anion transmembrane transporter activity
I6K52_RS01450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K52_RS01465	COG0673	inositol 2-dehydrogenase activity
I6K52_RS01475	COG1609	Transcriptional regulator
I6K52_RS01480	COG3706	GGDEF domain
I6K52_RS01485	COG0402	S-adenosylhomocysteine deaminase activity
I6K52_RS01490	COG1953	Uracil, thiamine, allantoin
I6K52_RS01525	COG0406	alpha-ribazole phosphatase activity
I6K52_RS01530	COG1335	isochorismatase
I6K52_RS01545	COG2207	Transcriptional regulator
I6K52_RS01560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K52_RS01630	COG0765	amino acid transport
I6K52_RS01640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K52_RS01650	COG2070	2-Nitropropane dioxygenase
I6K52_RS01655	COG0583	DNA-binding transcription factor activity
I6K52_RS01665	COG1902	pentaerythritol trinitrate reductase activity
I6K52_RS01670	COG4529	Protein conserved in bacteria
I6K52_RS01675	COG0477	Major facilitator Superfamily
I6K52_RS01705	COG2223	nitrite transmembrane transporter activity
I6K52_RS01715	COG1609	Transcriptional regulator
I6K52_RS01720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS01730	COG3037	sugar-specific permease SgaT UlaA
I6K52_RS01735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K52_RS01745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K52_RS01750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K52_RS01750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K52_RS01750	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K52_RS01765	COG0583	DNA-binding transcription factor activity
I6K52_RS01770	COG0583	DNA-binding transcription factor activity
I6K52_RS01775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K52_RS01785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K52_RS01800	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS01810	COG1609	Transcriptional regulator
I6K52_RS01840	COG1652	LysM domain
I6K52_RS01865	COG0456	acetyltransferase
I6K52_RS01865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K52_RS01875	COG0667	Aldo Keto reductase
I6K52_RS01880	COG0667	Aldo Keto reductase
I6K52_RS01885	COG3386	PFAM SMP-30 Gluconolaconase
I6K52_RS01890	COG0667	Aldo Keto reductase
I6K52_RS01915	COG4977	sequence-specific DNA binding
I6K52_RS01935	COG4977	sequence-specific DNA binding
I6K52_RS01940	COG1349	DNA-binding transcription factor activity
I6K52_RS01955	COG1349	DNA-binding transcription factor activity
I6K52_RS01960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K52_RS01965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K52_RS01970	COG0738	Major facilitator superfamily
I6K52_RS02015	COG1929	Belongs to the glycerate kinase type-1 family
I6K52_RS02020	COG3835	regulator
I6K52_RS02040	COG2186	Transcriptional regulator
I6K52_RS02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS02045	COG1263	PTS System
I6K52_RS02055	COG2814	Major facilitator Superfamily
I6K52_RS02060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS02060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS02075	COG2819	hydrolase of the alpha beta superfamily
I6K52_RS02080	COG3300	MHYT domain
I6K52_RS02080	COG5001	Diguanylate cyclase
I6K52_RS02115	COG3188	usher protein
I6K52_RS02125	COG1649	PFAM Uncharacterised BCR, COG1649
I6K52_RS02130	COG3550	peptidyl-serine autophosphorylation
I6K52_RS02135	COG1396	sequence-specific DNA binding
I6K52_RS02140	COG2351	hydroxyisourate hydrolase activity
I6K52_RS02145	COG3648	Uricase
I6K52_RS02145	COG3195	allantoin biosynthetic process
I6K52_RS02150	COG2233	PERMEase
I6K52_RS02180	COG2207	Transcriptional regulator
I6K52_RS02195	COG4628	conserved protein (DUF2132)
I6K52_RS02215	COG2011	ABC-type metal ion transport system permease component
I6K52_RS02220	COG2070	2-Nitropropane dioxygenase
I6K52_RS02230	COG0477	Major facilitator Superfamily
I6K52_RS02300	COG2199	diguanylate cyclase activity
I6K52_RS02315	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS02320	COG0583	DNA-binding transcription factor activity
I6K52_RS02330	COG0039	L-malate dehydrogenase activity
I6K52_RS02335	COG1349	DNA-binding transcription factor activity
I6K52_RS02340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K52_RS02345	COG3395	kinase activity
I6K52_RS02355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K52_RS02360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K52_RS02365	COG2271	Major facilitator Superfamily
I6K52_RS02395	COG4977	sequence-specific DNA binding
I6K52_RS02405	COG0697	spore germination
I6K52_RS02410	COG2814	Major facilitator Superfamily
I6K52_RS02425	COG1129	ABC transporter
I6K52_RS02440	COG0683	leucine binding
I6K52_RS02445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K52_RS02480	COG2223	nitrite transmembrane transporter activity
I6K52_RS02485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K52_RS02500	COG1349	DNA-binding transcription factor activity
I6K52_RS02505	COG2084	Dehydrogenase
I6K52_RS02510	COG3395	kinase activity
I6K52_RS02515	COG0235	Class ii aldolase
I6K52_RS02520	COG3622	Belongs to the hyi family
I6K52_RS02525	COG2610	gluconate transmembrane transporter activity
I6K52_RS02530	COG3708	Transcriptional regulator
I6K52_RS02530	COG2207	Transcriptional regulator
I6K52_RS02545	COG2200	EAL domain
I6K52_RS02550	COG1546	Belongs to the CinA family
I6K52_RS02555	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K52_RS02575	COG2197	response regulator
I6K52_RS02585	COG2135	peptidase activity
I6K52_RS02590	COG2207	Transcriptional regulator
I6K52_RS02605	COG4221	oxidoreductase activity
I6K52_RS02610	COG1802	Transcriptional regulator
I6K52_RS02615	COG0589	response to stress
I6K52_RS02620	COG0246	Mannitol dehydrogenase
I6K52_RS02625	COG2271	Major facilitator Superfamily
I6K52_RS02640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K52_RS02655	COG0243	molybdopterin cofactor binding
I6K52_RS02660	COG0437	4 iron, 4 sulfur cluster binding
I6K52_RS02665	COG3302	dmso reductase anchor subunit
I6K52_RS02680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K52_RS02685	COG1940	carbohydrate kinase activity
I6K52_RS02690	COG0583	DNA-binding transcription factor activity
I6K52_RS02695	COG2814	Major facilitator Superfamily
I6K52_RS02700	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K52_RS02710	COG3591	Belongs to the peptidase S1B family
I6K52_RS02730	COG0628	permease
I6K52_RS02760	COG0679	Auxin Efflux Carrier
I6K52_RS02770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K52_RS02795	COG3290	protein histidine kinase activity
I6K52_RS02800	COG4565	transcriptional regulatory protein
I6K52_RS02820	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K52_RS02820	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K52_RS02830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K52_RS02835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K52_RS02845	COG0183	Belongs to the thiolase family
I6K52_RS02850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K52_RS02860	COG1414	Transcriptional regulator
I6K52_RS02865	COG2840	Smr protein MutS2
I6K52_RS02870	COG0583	DNA-binding transcription factor activity
I6K52_RS02880	COG1473	amidohydrolase
I6K52_RS02885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K52_RS02900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K52_RS02915	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K52_RS02920	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K52_RS02935	COG0531	amino acid
I6K52_RS02945	COG3136	membrane protein required for alginate biosynthesis
I6K52_RS02950	COG0745	RESPONSE REGULATOR receiver
I6K52_RS02960	COG2205	protein histidine kinase activity
I6K52_RS02970	COG0114	fumarate hydratase activity
I6K52_RS02975	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K52_RS02975	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K52_RS02980	COG1482	cell wall glycoprotein biosynthetic process
I6K52_RS02985	COG5339	Protein conserved in bacteria
I6K52_RS02990	COG1609	Transcriptional regulator
I6K52_RS02995	COG1263	PTS System
I6K52_RS02995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS03000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K52_RS03025	COG2391	methyltransferase activity
I6K52_RS03030	COG0425	Belongs to the sulfur carrier protein TusA family
I6K52_RS03035	COG5562	phage envelope protein
I6K52_RS03040	COG0401	homolog of Blt101
I6K52_RS03045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K52_RS03050	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS03060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K52_RS03070	COG1113	amino acid transport
I6K52_RS03075	COG2988	succinylglutamate desuccinylase activity
I6K52_RS03080	COG3724	N-succinylarginine dihydrolase activity
I6K52_RS03085	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS03090	COG3138	arginine N-succinyltransferase
I6K52_RS03095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K52_RS03105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K52_RS03110	COG0667	Aldo Keto reductase
I6K52_RS03115	COG0583	DNA-binding transcription factor activity
I6K52_RS03140	COG4122	O-methyltransferase activity
I6K52_RS03145	COG1643	Atp-dependent helicase
I6K52_RS03160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K52_RS03165	COG3327	negative regulation of DNA-templated transcription, initiation
I6K52_RS03170	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K52_RS03175	COG0183	Belongs to the thiolase family
I6K52_RS03180	COG2050	protein possibly involved in aromatic compounds catabolism
I6K52_RS03185	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K52_RS03190	COG1024	Enoyl-CoA hydratase
I6K52_RS03195	COG1024	Enoyl-CoA hydratase
I6K52_RS03200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K52_RS03205	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K52_RS03210	COG3396	Phenylacetate-CoA oxygenase
I6K52_RS03215	COG3460	Phenylacetate-CoA oxygenase
I6K52_RS03220	COG3396	Phenylacetate-CoA oxygenase
I6K52_RS03225	COG2030	dehydratase
I6K52_RS03225	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS03245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K52_RS03260	COG2072	flavoprotein involved in K transport
I6K52_RS03265	COG0583	DNA-binding transcription factor activity
I6K52_RS03270	COG1126	abc transporter atp-binding protein
I6K52_RS03280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS03295	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS03300	COG2207	Transcriptional regulator
I6K52_RS03305	COG3784	Protein of unknown function (DUF1318)
I6K52_RS03315	COG2911	Protein conserved in bacteria
I6K52_RS03320	COG0586	Pfam SNARE associated Golgi protein
I6K52_RS03325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K52_RS03330	COG3187	Heat shock protein
I6K52_RS03335	COG3042	response to heat
I6K52_RS03340	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K52_RS03340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K52_RS03340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K52_RS03340	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K52_RS03345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K52_RS03355	COG0589	response to stress
I6K52_RS03365	COG0513	Belongs to the DEAD box helicase family
I6K52_RS03375	COG1349	DNA-binding transcription factor activity
I6K52_RS03380	COG0673	inositol 2-dehydrogenase activity
I6K52_RS03395	COG1113	amino acid transport
I6K52_RS03400	COG1522	sequence-specific DNA binding
I6K52_RS03410	COG1448	Aminotransferase
I6K52_RS03415	COG2011	ABC-type metal ion transport system permease component
I6K52_RS03430	COG0436	Aminotransferase
I6K52_RS03435	COG0604	alcohol dehydrogenase
I6K52_RS03465	COG0583	DNA-binding transcription factor activity
I6K52_RS03485	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS03490	COG1309	transcriptional regulator
I6K52_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS03605	COG2885	chlorophyll binding
I6K52_RS03630	COG0693	protein deglycase activity
I6K52_RS03635	COG1078	dGTPase activity
I6K52_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS03645	COG0583	DNA-binding transcription factor activity
I6K52_RS03660	COG0656	L-ascorbic acid biosynthetic process
I6K52_RS03690	COG4166	transmembrane transport
I6K52_RS03700	COG2866	Carboxypeptidase
I6K52_RS03705	COG4948	Mandelate Racemase Muconate Lactonizing
I6K52_RS03710	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K52_RS03715	COG3180	Ammonia monooxygenase
I6K52_RS03725	COG1486	melibiose metabolic process
I6K52_RS03730	COG0583	DNA-binding transcription factor activity
I6K52_RS03740	COG3106	COG3106 Predicted ATPase
I6K52_RS03750	COG1983	PspC domain protein
I6K52_RS03760	COG1842	Phage shock protein A
I6K52_RS03765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K52_RS03775	COG1473	amidohydrolase
I6K52_RS03790	COG0702	epimerase
I6K52_RS03805	COG4171	peptide transport system, permease
I6K52_RS03820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K52_RS03830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K52_RS03835	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K52_RS03835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K52_RS03850	COG1349	DNA-binding transcription factor activity
I6K52_RS03860	COG0023	Translation Initiation Factor
I6K52_RS03870	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K52_RS03875	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K52_RS03880	COG0671	phosphoesterase, PA-phosphatase related
I6K52_RS03890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K52_RS03915	COG0616	signal peptide processing
I6K52_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS03930	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K52_RS03940	COG0583	DNA-binding transcription factor activity
I6K52_RS03950	COG0009	L-threonylcarbamoyladenylate synthase
I6K52_RS03960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K52_RS03965	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K52_RS03965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K52_RS03970	COG0134	indole-3-glycerol-phosphate synthase activity
I6K52_RS03970	COG0135	phosphoribosylanthranilate isomerase activity
I6K52_RS04005	COG4774	siderophore transport
I6K52_RS04015	COG3047	cAMP biosynthetic process
I6K52_RS04020	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K52_RS04050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K52_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS04060	COG1988	membrane-bound metal-dependent
I6K52_RS04065	COG1823	symporter activity
I6K52_RS04075	COG0753	catalase activity
I6K52_RS04085	COG1486	melibiose metabolic process
I6K52_RS04090	COG1917	Cupin 2, conserved barrel domain protein
I6K52_RS04090	COG2169	Transcriptional regulator
I6K52_RS04095	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K52_RS04100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS04110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS04115	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K52_RS04125	COG0322	excinuclease ABC activity
I6K52_RS04130	COG3678	ATP-independent chaperone mediated protein folding
I6K52_RS04140	COG3724	N-succinylarginine dihydrolase activity
I6K52_RS04150	COG3138	arginine N-succinyltransferase
I6K52_RS04160	COG0708	Exodeoxyribonuclease III
I6K52_RS04165	COG0398	Pfam SNARE associated Golgi protein
I6K52_RS04170	COG0398	Pfam SNARE associated Golgi protein
I6K52_RS04175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K52_RS04180	COG4134	Bacterial extracellular solute-binding protein
I6K52_RS04185	COG4135	transport system, permease component
I6K52_RS04190	COG4136	ATPase activity
I6K52_RS04195	COG2897	thiosulfate sulfurtransferase activity
I6K52_RS04200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K52_RS04205	COG0494	nUDIX hydrolase
I6K52_RS04210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K52_RS04215	COG0604	alcohol dehydrogenase
I6K52_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS04215	COG3321	synthase
I6K52_RS04220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K52_RS04225	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K52_RS04240	COG0778	Nitroreductase
I6K52_RS04245	COG0616	signal peptide processing
I6K52_RS04250	COG0252	asparaginase activity
I6K52_RS04255	COG1335	isochorismatase
I6K52_RS04270	COG3139	Protein of unknown function (DUF1315)
I6K52_RS04290	COG0656	L-ascorbic acid biosynthetic process
I6K52_RS04295	COG3713	MltA-interacting MipA family protein
I6K52_RS04300	COG2766	serine protein kinase
I6K52_RS04315	COG0386	Belongs to the glutathione peroxidase family
I6K52_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS04345	COG0583	DNA-binding transcription factor activity
I6K52_RS04350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K52_RS04355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K52_RS04365	COG0859	PFAM glycosyl transferase family 9
I6K52_RS04370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K52_RS04380	COG2207	Transcriptional regulator
I6K52_RS04385	COG2807	transmembrane transport
I6K52_RS04390	COG0504	CTP synthase activity
I6K52_RS04395	COG1683	Conserved Protein
I6K52_RS04400	COG3189	MarR family transcriptional regulator
I6K52_RS04405	COG3042	response to heat
I6K52_RS04410	COG2199	diguanylate cyclase activity
I6K52_RS04410	COG2203	Gaf domain
I6K52_RS04430	COG3182	Iron-regulated membrane protein
I6K52_RS04440	COG1560	Kdo2-lipid A biosynthetic process
I6K52_RS04450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K52_RS04455	COG3706	GGDEF domain
I6K52_RS04460	COG0583	DNA-binding transcription factor activity
I6K52_RS04465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K52_RS04495	COG1294	oxidase, subunit
I6K52_RS04500	COG1271	oxidase subunit
I6K52_RS04505	COG3546	catalase activity
I6K52_RS04510	COG3685	Protein conserved in bacteria
I6K52_RS04515	COG3685	Protein conserved in bacteria
I6K52_RS04520	COG3729	General stress protein
I6K52_RS04530	COG1063	alcohol dehydrogenase
I6K52_RS04535	COG3813	Protein conserved in bacteria
I6K52_RS04560	COG0640	Transcriptional regulator
I6K52_RS04565	COG0538	isocitrate dehydrogenase activity
I6K52_RS04745	COG3179	chitinase
I6K52_RS04780	COG1403	HNH endonuclease
I6K52_RS04785	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K52_RS04795	COG1846	Transcriptional regulator
I6K52_RS04860	COG0582	viral genome integration into host DNA
I6K52_RS04865	COG0538	isocitrate dehydrogenase activity
I6K52_RS04870	COG1187	pseudouridine synthase activity
I6K52_RS04890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K52_RS04910	COG2205	protein histidine kinase activity
I6K52_RS04915	COG2850	peptidyl-arginine hydroxylation
I6K52_RS04920	COG1943	Transposase
I6K52_RS04940	COG1177	transmembrane transport
I6K52_RS04955	COG0318	PFAM AMP-dependent synthetase and ligase
I6K52_RS04960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K52_RS04965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K52_RS04970	COG0698	ribose 5-phosphate isomerase
I6K52_RS04985	COG3395	kinase activity
I6K52_RS05000	COG2390	Transcriptional regulator
I6K52_RS05010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K52_RS05020	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K52_RS05030	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K52_RS05040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K52_RS05045	COG1376	ErfK ybiS ycfS ynhG family protein
I6K52_RS05045	COG1388	LysM domain
I6K52_RS05060	COG1309	transcriptional regulator
I6K52_RS05075	COG3134	Outer membrane lipoprotein
I6K52_RS05080	COG1252	NADH dehydrogenase
I6K52_RS05105	COG5633	Lipoprotein
I6K52_RS05110	COG0537	adenosine 5'-monophosphoramidase activity
I6K52_RS05120	COG0084	hydrolase, TatD family'
I6K52_RS05125	COG0470	DNA polymerase III
I6K52_RS05135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K52_RS05140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K52_RS05145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K52_RS05160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K52_RS05180	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K52_RS05200	COG1530	ribonuclease E activity
I6K52_RS05205	COG0583	DNA-binding transcription factor activity
I6K52_RS05210	COG2814	Major facilitator Superfamily
I6K52_RS05230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K52_RS05275	COG1560	Kdo2-lipid A biosynthetic process
I6K52_RS05290	COG5645	(Lipo)protein
I6K52_RS05325	COG3381	protein complex oligomerization
I6K52_RS05355	COG0583	DNA-binding transcription factor activity
I6K52_RS05365	COG1335	isochorismatase
I6K52_RS05380	COG1702	phosphate starvation-inducible protein PhoH
I6K52_RS05400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K52_RS05410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K52_RS05425	COG1309	transcriptional regulator
I6K52_RS05460	COG2233	PERMEase
I6K52_RS05470	COG3729	General stress protein
I6K52_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS05515	COG0531	amino acid
I6K52_RS05520	COG0174	glutamine synthetase
I6K52_RS05525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K52_RS05530	COG1917	Cupin 2, conserved barrel domain protein
I6K52_RS05530	COG1396	sequence-specific DNA binding
I6K52_RS05535	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS05540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K52_RS05545	COG0583	DNA-binding transcription factor activity
I6K52_RS05550	COG0473	3-isopropylmalate dehydrogenase activity
I6K52_RS05555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K52_RS05565	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS05570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K52_RS05595	COG0670	Belongs to the BI1 family
I6K52_RS05610	COG2207	Transcriptional regulator
I6K52_RS05615	COG1881	PFAM PEBP family protein
I6K52_RS05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS05645	COG2274	protein secretion by the type I secretion system
I6K52_RS05660	COG1832	CoA-binding protein
I6K52_RS05670	COG0210	DNA helicase
I6K52_RS05675	COG3304	Inner membrane component domain
I6K52_RS05680	COG1289	transmembrane transporter activity
I6K52_RS05685	COG3070	regulator of competence-specific genes
I6K52_RS05705	COG1067	ATP-dependent peptidase activity
I6K52_RS05715	COG3130	regulation of translation
I6K52_RS05720	COG3009	Protein conserved in bacteria
I6K52_RS05725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K52_RS05725	COG3008	intermembrane lipid transfer
I6K52_RS05730	COG2995	paraquat-inducible protein a
I6K52_RS05735	COG0488	(ABC) transporter
I6K52_RS05745	COG3217	Mosc domain protein beta barrel domain protein
I6K52_RS05745	COG0633	Ferredoxin
I6K52_RS05760	COG0431	NADPH-dependent FMN reductase
I6K52_RS05765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K52_RS05770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K52_RS05775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K52_RS05785	COG0308	aminopeptidase N
I6K52_RS05795	COG1473	amidohydrolase
I6K52_RS05805	COG0814	amino acid
I6K52_RS05825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K52_RS05830	COG1448	Aminotransferase
I6K52_RS05835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K52_RS05840	COG3108	Peptidase M15
I6K52_RS05845	COG2989	Protein conserved in bacteria
I6K52_RS05855	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K52_RS05865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K52_RS05870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K52_RS05875	COG3173	Aminoglycoside phosphotransferase
I6K52_RS05890	COG3214	Protein conserved in bacteria
I6K52_RS05905	COG0658	competence protein
I6K52_RS05905	COG2333	competence protein COMEC
I6K52_RS05915	COG0539	negative regulation of cytoplasmic translation
I6K52_RS05935	COG2323	membrane
I6K52_RS05940	COG1944	ATP diphosphatase activity
I6K52_RS05945	COG2116	formate transmembrane transporter activity
I6K52_RS05950	COG1882	Formate acetyltransferase
I6K52_RS05955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K52_RS05960	COG0477	Major facilitator Superfamily
I6K52_RS05965	COG3302	dmso reductase anchor subunit
I6K52_RS05970	COG0437	4 iron, 4 sulfur cluster binding
I6K52_RS05975	COG0243	molybdopterin cofactor binding
I6K52_RS05985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K52_RS05995	COG1674	ftsk spoiiie
I6K52_RS05995	COG1178	ABC-type Fe3 transport system permease component
I6K52_RS06005	COG0492	ferredoxin-NADP+ reductase activity
I6K52_RS06010	COG4988	ABC transporter
I6K52_RS06015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K52_RS06030	COG0542	response to heat
I6K52_RS06040	COG1278	Cold shock
I6K52_RS06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS06055	COG3593	DNA synthesis involved in DNA repair
I6K52_RS06065	COG2431	L-lysine efflux transmembrane transporter activity
I6K52_RS06075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K52_RS06085	COG0028	Belongs to the TPP enzyme family
I6K52_RS06090	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K52_RS06095	COG0702	epimerase
I6K52_RS06100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K52_RS06105	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K52_RS06110	COG5001	Diguanylate cyclase
I6K52_RS06110	COG3706	GGDEF domain
I6K52_RS06110	COG2203	Gaf domain
I6K52_RS06110	COG4251	negative regulation of phosphorylation
I6K52_RS06120	COG1126	abc transporter atp-binding protein
I6K52_RS06125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS06130	COG4215	(ABC) transporter
I6K52_RS06135	COG4160	amino acid transport
I6K52_RS06140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS06145	COG5002	protein histidine kinase activity
I6K52_RS06150	COG0745	RESPONSE REGULATOR receiver
I6K52_RS06165	COG1177	transmembrane transport
I6K52_RS06170	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K52_RS06175	COG3842	ATPase activity
I6K52_RS06180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K52_RS06195	COG0778	Nitroreductase
I6K52_RS06220	COG3226	Transcriptional regulator
I6K52_RS06225	COG0738	Major facilitator superfamily
I6K52_RS06230	COG0561	phosphatase activity
I6K52_RS06235	COG2814	Major facilitator Superfamily
I6K52_RS06240	COG0671	phosphoesterase, PA-phosphatase related
I6K52_RS06245	COG1349	DNA-binding transcription factor activity
I6K52_RS06250	COG1686	Belongs to the peptidase S11 family
I6K52_RS06260	COG0625	glutathione transferase activity
I6K52_RS06265	COG2133	pyrroloquinoline quinone binding
I6K52_RS06275	COG2223	nitrite transmembrane transporter activity
I6K52_RS06295	COG0747	negative chemotaxis
I6K52_RS06310	COG0303	'Molybdopterin
I6K52_RS06315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K52_RS06320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K52_RS06325	COG1882	Formate acetyltransferase
I6K52_RS06330	COG0561	phosphatase activity
I6K52_RS06340	COG1609	Transcriptional regulator
I6K52_RS06345	COG2271	Major facilitator Superfamily
I6K52_RS06355	COG0488	(ABC) transporter
I6K52_RS06360	COG2365	Tyrosine phosphatase family
I6K52_RS06365	COG1376	ErfK ybiS ycfS ynhG family protein
I6K52_RS06370	COG2188	Transcriptional regulator
I6K52_RS06375	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS06380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K52_RS06395	COG2194	sulfuric ester hydrolase activity
I6K52_RS06400	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K52_RS06415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS06420	COG0765	amino acid transport
I6K52_RS06425	COG1126	abc transporter atp-binding protein
I6K52_RS06430	COG0668	transmembrane transport
I6K52_RS06440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K52_RS06450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K52_RS06460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K52_RS06465	COG1199	ATP-dependent helicase activity
I6K52_RS06470	COG0513	Belongs to the DEAD box helicase family
I6K52_RS06475	COG3958	Transketolase
I6K52_RS06480	COG3959	Transketolase, thiamine diphosphate binding domain
I6K52_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS06490	COG2271	Major facilitator Superfamily
I6K52_RS06500	COG0583	DNA-binding transcription factor activity
I6K52_RS06505	COG1309	transcriptional regulator
I6K52_RS06510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS06515	COG1131	(ABC) transporter
I6K52_RS06520	COG0842	Transport permease protein
I6K52_RS06525	COG0842	Transport permease protein
I6K52_RS06535	COG3568	Endonuclease Exonuclease Phosphatase
I6K52_RS06540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K52_RS06545	COG0392	lysyltransferase activity
I6K52_RS06555	COG0670	Belongs to the BI1 family
I6K52_RS06560	COG0314	molybdopterin synthase activity
I6K52_RS06565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K52_RS06575	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K52_RS06595	COG0745	RESPONSE REGULATOR receiver
I6K52_RS06600	COG0642	Histidine kinase
I6K52_RS06625	COG2226	methyltransferase
I6K52_RS06640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K52_RS06645	COG1881	PFAM PEBP family protein
I6K52_RS06685	COG4677	pectinesterase activity
I6K52_RS06695	COG0589	response to stress
I6K52_RS06700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS06735	COG0789	Transcriptional regulator
I6K52_RS06740	COG2200	EAL domain
I6K52_RS06765	COG0561	phosphatase activity
I6K52_RS06770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K52_RS06775	COG4149	molybdate abc transporter
I6K52_RS06780	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K52_RS06790	COG3585	molybdate ion transport
I6K52_RS06790	COG2005	Transcriptional regulator
I6K52_RS06795	COG1119	ATPase activity
I6K52_RS06805	COG1085	galactose-1-phosphate uridylyltransferase
I6K52_RS06815	COG2017	converts alpha-aldose to the beta-anomer
I6K52_RS06825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K52_RS06840	COG3201	nicotinamide mononucleotide transporter
I6K52_RS06845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K52_RS06895	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K52_RS06900	COG2885	chlorophyll binding
I6K52_RS06910	COG3064	Membrane
I6K52_RS06915	COG0848	biopolymer transport protein
I6K52_RS06920	COG0811	peptide transport
I6K52_RS06925	COG0824	Thioesterase
I6K52_RS06930	COG3790	cyd operon protein YbgE
I6K52_RS06935	COG4890	Cyd operon protein YbgT
I6K52_RS06940	COG1294	oxidase, subunit
I6K52_RS06945	COG1271	oxidase subunit
I6K52_RS06950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K52_RS06960	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K52_RS06965	COG0567	Dehydrogenase, E1 component
I6K52_RS06970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K52_RS06975	COG1053	succinate dehydrogenase
I6K52_RS06980	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K52_RS06985	COG2009	succinate dehydrogenase
I6K52_RS07020	COG1984	allophanate hydrolase subunit 2
I6K52_RS07025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K52_RS07040	COG0415	Belongs to the DNA photolyase family
I6K52_RS07070	COG2205	protein histidine kinase activity
I6K52_RS07075	COG0745	RESPONSE REGULATOR receiver
I6K52_RS07085	COG0033	Phosphoglucomutase
I6K52_RS07095	COG0596	Alpha beta hydrolase
I6K52_RS07110	COG0735	belongs to the Fur family
I6K52_RS07150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K52_RS07155	COG1940	carbohydrate kinase activity
I6K52_RS07155	COG1846	Transcriptional regulator
I6K52_RS07160	COG0647	UMP catabolic process
I6K52_RS07165	COG0367	asparagine synthase
I6K52_RS07205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K52_RS07215	COG1702	phosphate starvation-inducible protein PhoH
I6K52_RS07240	COG0765	amino acid transport
I6K52_RS07245	COG0765	amino acid transport
I6K52_RS07250	COG1126	abc transporter atp-binding protein
I6K52_RS07265	COG2888	peptidyl-tyrosine sulfation
I6K52_RS07280	COG1466	dna polymerase III delta subunit
I6K52_RS07295	COG0799	negative regulation of ribosome biogenesis
I6K52_RS07305	COG0768	penicillin binding
I6K52_RS07310	COG0772	Belongs to the SEDS family
I6K52_RS07315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K52_RS07320	COG1686	Belongs to the peptidase S11 family
I6K52_RS07335	COG0583	DNA-binding transcription factor activity
I6K52_RS07350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K52_RS07370	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K52_RS07375	COG3719	Belongs to the RNase T2 family
I6K52_RS07380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K52_RS07400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K52_RS07405	COG0583	DNA-binding transcription factor activity
I6K52_RS07410	COG3969	phosphoadenosine phosphosulfate
I6K52_RS07415	COG1475	DNA binding
I6K52_RS07420	COG0436	Aminotransferase
I6K52_RS07445	COG1129	ABC transporter
I6K52_RS07450	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS07455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS07465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K52_RS07480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K52_RS07490	COG0402	S-adenosylhomocysteine deaminase activity
I6K52_RS07500	COG0483	inositol monophosphate 1-phosphatase activity
I6K52_RS07505	COG2271	Major facilitator Superfamily
I6K52_RS07535	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS07540	COG1129	ABC transporter
I6K52_RS07545	COG0371	Dehydrogenase
I6K52_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS07565	COG2879	small protein
I6K52_RS07570	COG1966	Carbon starvation protein
I6K52_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS07585	COG3433	isochorismatase activity
I6K52_RS07585	COG1535	isochorismatase
I6K52_RS07590	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K52_RS07595	COG1169	isochorismate synthase
I6K52_RS07600	COG4592	Periplasmic binding protein
I6K52_RS07610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS07615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS07620	COG1120	ATPase activity
I6K52_RS07625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K52_RS07625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K52_RS07630	COG3251	PFAM MbtH domain protein
I6K52_RS07635	COG2382	esterase
I6K52_RS07640	COG4771	TonB-dependent receptor
I6K52_RS07650	COG1879	ABC-type sugar transport system periplasmic component
I6K52_RS07660	COG1129	ABC transporter
I6K52_RS07665	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS07670	COG5464	transposase or invertase
I6K52_RS07675	COG2390	Transcriptional regulator
I6K52_RS07680	COG3959	Transketolase, thiamine diphosphate binding domain
I6K52_RS07685	COG3958	Transketolase
I6K52_RS07695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K52_RS07705	COG0583	DNA-binding transcription factor activity
I6K52_RS07710	COG0668	transmembrane transport
I6K52_RS07720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K52_RS07745	COG0747	negative chemotaxis
I6K52_RS07750	COG0601	transmembrane transport
I6K52_RS07755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K52_RS07760	COG0444	Belongs to the ABC transporter superfamily
I6K52_RS07765	COG4608	Belongs to the ABC transporter superfamily
I6K52_RS07775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K52_RS07780	COG4221	oxidoreductase activity
I6K52_RS07790	COG4215	(ABC) transporter
I6K52_RS07795	COG0765	amino acid transport
I6K52_RS07800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K52_RS07815	COG0697	spore germination
I6K52_RS07825	COG3698	Phosphodiester glycosidase
I6K52_RS07870	COG2315	Protein conserved in bacteria
I6K52_RS07875	COG0778	Nitroreductase
I6K52_RS07885	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS07895	COG3716	PTS system mannose fructose sorbose family IID component
I6K52_RS07900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K52_RS07905	COG2222	sugar isomerase
I6K52_RS07910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K52_RS07910	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K52_RS07925	COG0477	Major facilitator Superfamily
I6K52_RS07930	COG0668	transmembrane transport
I6K52_RS07935	COG1609	Transcriptional regulator
I6K52_RS07945	COG0673	inositol 2-dehydrogenase activity
I6K52_RS07955	COG2211	Major facilitator Superfamily
I6K52_RS07960	COG1113	amino acid transport
I6K52_RS07975	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS07980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K52_RS08035	COG0667	Aldo Keto reductase
I6K52_RS08040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS08045	COG1473	amidohydrolase
I6K52_RS08075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS08080	COG1120	ATPase activity
I6K52_RS08085	COG1566	PFAM secretion protein HlyD family protein
I6K52_RS08130	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS08135	COG1129	ABC transporter
I6K52_RS08150	COG0673	inositol 2-dehydrogenase activity
I6K52_RS08180	COG3104	oligopeptide transport
I6K52_RS08185	COG1982	Orn Lys Arg decarboxylase major
I6K52_RS08190	COG0531	amino acid
I6K52_RS08195	COG3710	Transcriptional regulator
I6K52_RS08205	COG1560	Kdo2-lipid A biosynthetic process
I6K52_RS08220	COG3188	usher protein
I6K52_RS08225	COG3121	Chaperone
I6K52_RS08230	COG3539	Fimbrial protein
I6K52_RS08285	COG2501	S4 domain
I6K52_RS08295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K52_RS08310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K52_RS08315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K52_RS08335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K52_RS08340	COG4181	ATPase activity
I6K52_RS08345	COG2755	lipolytic protein G-D-S-L family
I6K52_RS08350	COG0300	oxidoreductase activity
I6K52_RS08355	COG3118	belongs to the thioredoxin family
I6K52_RS08360	COG0390	transport system, permease component
I6K52_RS08365	COG4619	ABC transporter
I6K52_RS08370	COG0330	HflC and HflK could
I6K52_RS08375	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K52_RS08390	COG3735	TraB family
I6K52_RS08395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K52_RS08405	COG2223	nitrite transmembrane transporter activity
I6K52_RS08410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K52_RS08410	COG4651	solute:proton antiporter activity
I6K52_RS08415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K52_RS08455	COG2832	Protein of unknown function (DUF454)
I6K52_RS08460	COG3923	Primosomal replication protein n
I6K52_RS08475	COG3264	Mechanosensitive ion channel
I6K52_RS08475	COG1196	nuclear chromosome segregation
I6K52_RS08480	COG1309	transcriptional regulator
I6K52_RS08485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS08490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K52_RS08505	COG0110	maltose O-acetyltransferase activity
I6K52_RS08555	COG1874	Beta-galactosidase
I6K52_RS08560	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K52_RS08565	COG3833	ABC-type maltose transport systems, permease component
I6K52_RS08570	COG1175	transmembrane transport
I6K52_RS08575	COG2182	Extracellular solute-binding protein
I6K52_RS08585	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K52_RS08600	COG2364	Membrane
I6K52_RS08630	COG3695	enzyme binding
I6K52_RS08635	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K52_RS08640	COG1946	Acyl-CoA thioesterase
I6K52_RS08645	COG0004	ammonium transporteR
I6K52_RS08650	COG0347	Belongs to the P(II) protein family
I6K52_RS08655	COG1132	(ABC) transporter
I6K52_RS08660	COG1132	(ABC) transporter
I6K52_RS08665	COG1522	sequence-specific DNA binding
I6K52_RS08680	COG4533	DNA binding
I6K52_RS08690	COG0824	Thioesterase
I6K52_RS08695	COG1555	photosystem II stabilization
I6K52_RS08700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K52_RS08705	COG0776	regulation of translation
I6K52_RS08710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K52_RS08730	COG0271	Belongs to the BolA IbaG family
I6K52_RS08735	COG3056	Lipoprotein
I6K52_RS08740	COG2223	nitrite transmembrane transporter activity
I6K52_RS08745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K52_RS08750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K52_RS08755	COG1845	cytochrome c oxidase, subunit III
I6K52_RS08760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K52_RS08775	COG1414	Transcriptional regulator
I6K52_RS08780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K52_RS08785	COG1053	succinate dehydrogenase
I6K52_RS08795	COG1053	succinate dehydrogenase
I6K52_RS08810	COG0673	inositol 2-dehydrogenase activity
I6K52_RS08815	COG2814	Major facilitator Superfamily
I6K52_RS08825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K52_RS08830	COG0693	protein deglycase activity
I6K52_RS08850	COG0142	geranyltranstransferase activity
I6K52_RS08860	COG0667	Aldo Keto reductase
I6K52_RS08865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K52_RS08885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K52_RS08885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K52_RS08895	COG4238	major outer membrane lipoprotein
I6K52_RS08915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K52_RS08920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K52_RS08925	COG1862	Preprotein translocase
I6K52_RS08950	COG0450	alkyl hydroperoxide reductase
I6K52_RS08960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS08975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K52_RS08985	COG1228	amidohydrolase
I6K52_RS08995	COG1335	isochorismatase
I6K52_RS09000	COG0583	DNA-binding transcription factor activity
I6K52_RS09005	COG0366	Alpha amylase catalytic
I6K52_RS09030	COG0420	3'-5' exonuclease activity
I6K52_RS09035	COG0419	ATPase involved in DNA repair
I6K52_RS09040	COG1940	carbohydrate kinase activity
I6K52_RS09055	COG4126	flavin adenine dinucleotide binding
I6K52_RS09065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K52_RS09070	COG3416	Protein conserved in bacteria
I6K52_RS09080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K52_RS09090	COG1785	Belongs to the alkaline phosphatase family
I6K52_RS09130	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K52_RS09135	COG1335	isochorismatase
I6K52_RS09140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K52_RS09145	COG0113	porphobilinogen synthase activity
I6K52_RS09155	COG2175	clavaminate synthase activity
I6K52_RS09160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K52_RS09165	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K52_RS09170	COG4521	taurine ABC transporter
I6K52_RS09175	COG2040	homocysteine
I6K52_RS09180	COG0833	amino acid
I6K52_RS09195	COG4303	Ethanolamine ammonia lyase large subunit
I6K52_RS09200	COG4302	ethanolamine ammonia-lyase activity
I6K52_RS09240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS09245	COG1126	abc transporter atp-binding protein
I6K52_RS09250	COG4597	amino acid ABC transporter
I6K52_RS09255	COG0765	amino acid transport
I6K52_RS09270	COG3188	usher protein
I6K52_RS09295	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K52_RS09305	COG3639	organic phosphonate transmembrane transporter activity
I6K52_RS09325	COG0791	NLP P60 protein
I6K52_RS09350	COG0582	viral genome integration into host DNA
I6K52_RS09430	COG3188	usher protein
I6K52_RS09435	COG3121	Chaperone
I6K52_RS09440	COG3539	Fimbrial protein
I6K52_RS09460	COG3710	Transcriptional regulator
I6K52_RS09490	COG2200	EAL domain
I6K52_RS09510	COG3121	Chaperone
I6K52_RS09535	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K52_RS09550	COG0579	oxidoreductase
I6K52_RS09555	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS09560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K52_RS09565	COG1113	amino acid transport
I6K52_RS09570	COG1802	Transcriptional regulator
I6K52_RS09590	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K52_RS09595	COG0454	-acetyltransferase
I6K52_RS09610	COG2991	Protein conserved in bacteria
I6K52_RS09625	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K52_RS09630	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K52_RS09645	COG3034	peptidoglycan biosynthetic process
I6K52_RS09650	COG0121	glutamine amidotransferase
I6K52_RS09660	COG1960	acyl-CoA dehydrogenase activity
I6K52_RS09665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K52_RS09675	COG0583	DNA-binding transcription factor activity
I6K52_RS09685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K52_RS09695	COG2226	methyltransferase
I6K52_RS09705	COG0741	lytic transglycosylase activity
I6K52_RS09705	COG1388	LysM domain
I6K52_RS09710	COG2226	methyltransferase
I6K52_RS09720	COG2814	Major facilitator Superfamily
I6K52_RS09725	COG0583	DNA-binding transcription factor activity
I6K52_RS09730	COG0656	L-ascorbic acid biosynthetic process
I6K52_RS09765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K52_RS09775	COG2011	ABC-type metal ion transport system permease component
I6K52_RS09780	COG1464	Belongs to the NlpA lipoprotein family
I6K52_RS09790	COG1720	tRNA m6t6A37 methyltransferase activity
I6K52_RS09800	COG0791	NLP P60 protein
I6K52_RS09805	COG3015	lipoprotein NlpE involved in copper resistance
I6K52_RS09810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K52_RS09825	COG4568	rho-dependent transcription termination
I6K52_RS09835	COG0346	lactoylglutathione lyase activity
I6K52_RS09840	COG1982	Orn Lys Arg decarboxylase major
I6K52_RS09850	COG0587	DNA-directed DNA polymerase activity
I6K52_RS09880	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K52_RS09890	COG0750	zinc metalloprotease
I6K52_RS09895	COG0575	Belongs to the CDS family
I6K52_RS09905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K52_RS09930	COG0024	Methionine aminopeptidase
I6K52_RS09935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K52_RS09950	COG3835	regulator
I6K52_RS09955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K52_RS09975	COG2860	membrane
I6K52_RS09995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS10000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K52_RS10005	COG1120	ATPase activity
I6K52_RS10010	COG4774	siderophore transport
I6K52_RS10015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K52_RS10105	COG1643	Atp-dependent helicase
I6K52_RS10110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K52_RS10130	COG0617	tRNA 3'-terminal CCA addition
I6K52_RS10135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K52_RS10155	COG0726	polysaccharide deacetylase
I6K52_RS10160	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS10165	COG0842	Transport permease protein
I6K52_RS10170	COG1131	(ABC) transporter
I6K52_RS10175	COG0288	reversible hydration of carbon dioxide
I6K52_RS10190	COG4993	Dehydrogenase
I6K52_RS10195	COG2132	Multicopper oxidase
I6K52_RS10240	COG3064	Membrane
I6K52_RS10255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K52_RS10260	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K52_RS10265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K52_RS10270	COG2186	Transcriptional regulator
I6K52_RS10275	COG1113	amino acid transport
I6K52_RS10280	COG2211	Major facilitator Superfamily
I6K52_RS10285	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K52_RS10290	COG3725	Membrane protein required for beta-lactamase induction
I6K52_RS10295	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K52_RS10305	COG4969	Belongs to the N-Me-Phe pilin family
I6K52_RS10310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K52_RS10315	COG1459	type II secretion system
I6K52_RS10340	COG0494	nUDIX hydrolase
I6K52_RS10360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K52_RS10365	COG0849	cell division
I6K52_RS10390	COG0772	Belongs to the SEDS family
I6K52_RS10405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K52_RS10410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K52_RS10415	COG0768	penicillin binding
I6K52_RS10435	COG1609	Transcriptional regulator
I6K52_RS10445	COG0028	Belongs to the TPP enzyme family
I6K52_RS10490	COG0738	Major facilitator superfamily
I6K52_RS10500	COG0583	DNA-binding transcription factor activity
I6K52_RS10505	COG2271	Major facilitator Superfamily
I6K52_RS10510	COG2814	Major facilitator Superfamily
I6K52_RS10530	COG1178	ABC-type Fe3 transport system permease component
I6K52_RS10540	COG0586	Pfam SNARE associated Golgi protein
I6K52_RS10560	COG0235	Class ii aldolase
I6K52_RS10565	COG0417	DNA replication proofreading
I6K52_RS10575	COG0564	pseudouridine synthase activity
I6K52_RS10585	COG3493	citrate carrier protein
I6K52_RS10600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K52_RS10605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K52_RS10615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K52_RS10660	COG0505	Belongs to the CarA family
I6K52_RS10725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K52_RS10750	COG1047	Peptidyl-prolyl cis-trans
I6K52_RS10765	COG0196	riboflavin kinase activity
I6K52_RS10775	COG0583	DNA-binding transcription factor activity
I6K52_RS10800	COG4735	regulation of single-species biofilm formation
I6K52_RS10805	COG1584	GPR1 FUN34 yaaH family protein
I6K52_RS10810	COG0477	Major facilitator Superfamily
I6K52_RS10815	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K52_RS10820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K52_RS10825	COG1115	amino acid carrier protein
I6K52_RS10840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K52_RS10850	COG0527	aspartate kinase activity
I6K52_RS10850	COG0460	homoserine dehydrogenase
I6K52_RS10860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K52_RS10870	COG0745	RESPONSE REGULATOR receiver
I6K52_RS10875	COG4452	Inner membrane protein CreD
I6K52_RS10880	COG2205	protein histidine kinase activity
I6K52_RS10885	COG0745	RESPONSE REGULATOR receiver
I6K52_RS10890	COG3045	CreA protein
I6K52_RS10895	COG3708	Transcriptional regulator
I6K52_RS10895	COG2207	Transcriptional regulator
I6K52_RS10915	COG0741	lytic transglycosylase activity
I6K52_RS10920	COG0488	(ABC) transporter
I6K52_RS10930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K52_RS10935	COG0560	Phosphoserine phosphatase
I6K52_RS10940	COG3726	membrane protein affecting hemolysin expression
I6K52_RS10970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K52_RS10975	COG0084	hydrolase, TatD family'
I6K52_RS10980	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K52_RS10990	COG2823	Periplasmic or secreted lipoprotein
I6K52_RS11000	COG1011	Hydrolase
I6K52_RS11005	COG0456	acetyltransferase
I6K52_RS11010	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K52_RS11045	COG3706	GGDEF domain
I6K52_RS11050	COG4114	ferric iron reductase
I6K52_RS11055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS11055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS11060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K52_RS11065	COG2197	response regulator
I6K52_RS11070	COG2197	response regulator
I6K52_RS11085	COG2966	Psort location CytoplasmicMembrane, score
I6K52_RS11100	COG1484	DNA-dependent DNA replication
I6K52_RS11115	COG5464	transposase or invertase
I6K52_RS11125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K52_RS11130	COG3716	PTS system mannose fructose sorbose family IID component
I6K52_RS11135	COG3715	PTS system
I6K52_RS11150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K52_RS11150	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K52_RS11155	COG0456	acetyltransferase
I6K52_RS11155	COG1214	PFAM Peptidase M22, glycoprotease
I6K52_RS11165	COG1737	Transcriptional regulator
I6K52_RS11170	COG0800	Aldolase
I6K52_RS11175	COG3734	2-keto-3-deoxy-galactonokinase
I6K52_RS11190	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K52_RS11215	COG1846	Transcriptional regulator
I6K52_RS11225	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K52_RS11235	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS11240	COG3384	dioxygenase
I6K52_RS11250	COG3971	2-oxopent-4-enoate hydratase activity
I6K52_RS11270	COG2368	4-hydroxyphenylacetate
I6K52_RS11275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K52_RS11290	COG1966	Carbon starvation protein
I6K52_RS11295	COG2879	small protein
I6K52_RS11300	COG0523	cobalamin synthesis protein
I6K52_RS11310	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS11315	COG5464	transposase or invertase
I6K52_RS11320	COG1917	Cupin 2, conserved barrel domain protein
I6K52_RS11320	COG2207	Transcriptional regulator
I6K52_RS11330	COG2733	membrane
I6K52_RS11345	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K52_RS11350	COG1924	4 iron, 4 sulfur cluster binding
I6K52_RS11365	COG1566	PFAM secretion protein HlyD family protein
I6K52_RS11375	COG5457	Domain of unknown function (DUF1127)
I6K52_RS11380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K52_RS11390	COG0583	DNA-binding transcription factor activity
I6K52_RS11395	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K52_RS11405	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS11410	COG1129	ABC transporter
I6K52_RS11415	COG1879	ABC-type sugar transport system periplasmic component
I6K52_RS11425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS11430	COG1129	ABC transporter
I6K52_RS11430	COG0842	Transport permease protein
I6K52_RS11435	COG0842	Transport permease protein
I6K52_RS11465	COG2850	peptidyl-arginine hydroxylation
I6K52_RS11480	COG5002	protein histidine kinase activity
I6K52_RS11485	COG0745	RESPONSE REGULATOR receiver
I6K52_RS11490	COG1538	Outer membrane efflux protein
I6K52_RS11495	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS11500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS11505	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K52_RS11515	COG3040	lipid binding
I6K52_RS11520	COG0789	Transcriptional regulator
I6K52_RS11530	COG0300	oxidoreductase activity
I6K52_RS11545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K52_RS11565	COG3272	Protein of unknown function (DUF1722)
I6K52_RS11570	COG4580	involved in the transport of maltose and maltodextrins
I6K52_RS11575	COG2115	Belongs to the xylose isomerase family
I6K52_RS11580	COG2211	Major facilitator Superfamily
I6K52_RS11585	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K52_RS11690	COG2003	Belongs to the UPF0758 family
I6K52_RS11705	COG3596	GTP binding
I6K52_RS11725	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6K52_RS11760	COG0582	viral genome integration into host DNA
I6K52_RS11770	COG0288	reversible hydration of carbon dioxide
I6K52_RS11775	COG0659	secondary active sulfate transmembrane transporter activity
I6K52_RS11780	COG1064	alcohol dehydrogenase
I6K52_RS11785	COG1175	transmembrane transport
I6K52_RS11790	COG0395	ABC-type sugar transport system, permease component
I6K52_RS11795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K52_RS11800	COG3842	ATPase activity
I6K52_RS11805	COG1653	transport
I6K52_RS11815	COG1082	Xylose isomerase domain protein TIM barrel
I6K52_RS11825	COG3962	Belongs to the TPP enzyme family
I6K52_RS11830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K52_RS11835	COG1737	Transcriptional regulator
I6K52_RS11835	COG0837	glucose binding
I6K52_RS11840	COG3718	enzyme involved in inositol metabolism
I6K52_RS11855	COG0433	COG0433 Predicted ATPase
I6K52_RS11860	COG0795	lipopolysaccharide-transporting ATPase activity
I6K52_RS11865	COG0795	lipopolysaccharide-transporting ATPase activity
I6K52_RS11875	COG2927	DNA polymerase III (CHI subunit)
I6K52_RS11880	COG0525	valine-tRNA ligase activity
I6K52_RS11905	COG2731	YhcH YjgK YiaL family protein
I6K52_RS11940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS11940	COG1263	PTS System
I6K52_RS11945	COG0366	Alpha amylase catalytic
I6K52_RS11950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS11955	COG1486	melibiose metabolic process
I6K52_RS11980	COG0602	queuosine metabolic process
I6K52_RS11985	COG2026	Addiction module toxin, RelE StbE family
I6K52_RS11990	COG3077	Addiction module antitoxin, RelB DinJ family
I6K52_RS11995	COG3711	transcriptional antiterminator
I6K52_RS11995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS12000	COG2706	6-phosphogluconolactonase activity
I6K52_RS12015	COG3964	amidohydrolase
I6K52_RS12050	COG0312	modulator of DNA gyrase
I6K52_RS12075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K52_RS12085	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS12090	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS12100	COG1879	ABC-type sugar transport system periplasmic component
I6K52_RS12120	COG2105	PFAM AIG2 family protein
I6K52_RS12125	COG2911	Protein conserved in bacteria
I6K52_RS12130	COG0729	surface antigen
I6K52_RS12140	COG1253	flavin adenine dinucleotide binding
I6K52_RS12155	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K52_RS12170	COG1733	regulation of RNA biosynthetic process
I6K52_RS12175	COG0702	epimerase
I6K52_RS12185	COG0697	spore germination
I6K52_RS12195	COG1113	amino acid transport
I6K52_RS12200	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K52_RS12205	COG3061	Opacity-associated protein A
I6K52_RS12215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K52_RS12220	COG2965	DNA replication, synthesis of RNA primer
I6K52_RS12280	COG1073	alpha beta
I6K52_RS12285	COG3650	response to hydrogen peroxide
I6K52_RS12295	COG1960	acyl-CoA dehydrogenase activity
I6K52_RS12300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K52_RS12305	COG0557	exoribonuclease II activity
I6K52_RS12320	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K52_RS12330	COG0330	HflC and HflK could
I6K52_RS12335	COG0330	HflC and HflK could
I6K52_RS12340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K52_RS12360	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K52_RS12365	COG0802	atpase or kinase
I6K52_RS12370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K52_RS12370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K52_RS12375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K52_RS12395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS12415	COG3264	Mechanosensitive ion channel
I6K52_RS12415	COG1511	domain protein
I6K52_RS12430	COG1053	succinate dehydrogenase
I6K52_RS12435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K52_RS12455	COG2076	Multidrug Resistance protein
I6K52_RS12460	COG5510	response to toxic substance
I6K52_RS12475	COG1509	lysine 2,3-aminomutase activity
I6K52_RS12540	COG0531	amino acid
I6K52_RS12545	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K52_RS12550	COG1027	Aspartate ammonia-lyase
I6K52_RS12555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K52_RS12570	COG1309	transcriptional regulator
I6K52_RS12600	COG0457	Tetratricopeptide repeat
I6K52_RS12605	COG0726	polysaccharide deacetylase
I6K52_RS12605	COG1649	PFAM Uncharacterised BCR, COG1649
I6K52_RS12610	COG1215	transferase activity, transferring glycosyl groups
I6K52_RS12625	COG0861	Integral membrane protein TerC family
I6K52_RS12670	COG1486	melibiose metabolic process
I6K52_RS12675	COG2169	Transcriptional regulator
I6K52_RS12685	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K52_RS12690	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K52_RS12695	COG2188	Transcriptional regulator
I6K52_RS12700	COG3624	Phosphonate C-P lyase system protein PhnG
I6K52_RS12705	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K52_RS12710	COG3626	phosphonate metabolism
I6K52_RS12715	COG3627	carbon phosphorus lyase activity
I6K52_RS12720	COG4107	phosphonate C-P lyase system protein PhnK
I6K52_RS12725	COG4778	phosphonate C-P lyase system protein PhnL
I6K52_RS12730	COG3454	Phosphonate metabolism
I6K52_RS12740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K52_RS12750	COG4191	Histidine kinase
I6K52_RS12750	COG0784	Response regulator, receiver
I6K52_RS12755	COG1129	ABC transporter
I6K52_RS12760	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS12800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K52_RS12805	COG1301	dicarboxylic acid transport
I6K52_RS12815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K52_RS12820	COG3162	membrane
I6K52_RS12850	COG3539	Fimbrial protein
I6K52_RS12855	COG1346	cytolysis
I6K52_RS12860	COG1380	Effector of murein hydrolase LrgA
I6K52_RS12865	COG0583	DNA-binding transcription factor activity
I6K52_RS12870	COG0025	NhaP-type Na H and K H
I6K52_RS12875	COG2252	PERMEase
I6K52_RS12880	COG0625	glutathione transferase activity
I6K52_RS12885	COG0789	Transcriptional regulator
I6K52_RS12895	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K52_RS12925	COG1234	tRNA 3'-trailer cleavage
I6K52_RS12930	COG1609	Transcriptional regulator
I6K52_RS12935	COG0483	inositol monophosphate 1-phosphatase activity
I6K52_RS12945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K52_RS12965	COG4771	TonB-dependent receptor
I6K52_RS12970	COG0741	lytic transglycosylase activity
I6K52_RS12985	COG2315	Protein conserved in bacteria
I6K52_RS12990	COG0432	Pfam Uncharacterised protein family UPF0047
I6K52_RS13005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K52_RS13010	COG0305	Participates in initiation and elongation during chromosome replication
I6K52_RS13025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K52_RS13035	COG0735	belongs to the Fur family
I6K52_RS13040	COG3237	CsbD-like
I6K52_RS13050	COG0534	Mate efflux family protein
I6K52_RS13060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K52_RS13130	COG0251	oxidation-reduction process
I6K52_RS13140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K52_RS13150	COG0527	aspartate kinase activity
I6K52_RS13205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K52_RS13235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K52_RS13245	COG0456	acetyltransferase
I6K52_RS13275	COG0151	Belongs to the GarS family
I6K52_RS13285	COG4191	Histidine kinase
I6K52_RS13290	COG3678	ATP-independent chaperone mediated protein folding
I6K52_RS13325	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K52_RS13340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K52_RS13345	COG2104	thiamine diphosphate biosynthetic process
I6K52_RS13360	COG3706	GGDEF domain
I6K52_RS13370	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K52_RS13375	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K52_RS13410	COG0250	Participates in transcription elongation, termination and antitermination
I6K52_RS13485	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K52_RS13495	COG1739	Uncharacterized protein family UPF0029
I6K52_RS13535	COG0805	protein transport
I6K52_RS13555	COG3165	ubiquinone biosynthetic process from chorismate
I6K52_RS13585	COG0583	DNA-binding transcription factor activity
I6K52_RS13590	COG0697	spore germination
I6K52_RS13595	COG0561	phosphatase activity
I6K52_RS13600	COG2267	carboxylic ester hydrolase activity
I6K52_RS13605	COG1280	lysine exporter protein (LysE YggA)
I6K52_RS13615	COG1280	lysine exporter protein (LysE YggA)
I6K52_RS13645	COG0210	DNA helicase
I6K52_RS13650	COG1011	Hydrolase
I6K52_RS13680	COG3072	Adenylate cyclase
I6K52_RS13695	COG2959	enzyme of heme biosynthesis
I6K52_RS13700	COG3071	HemY protein
I6K52_RS13745	COG2244	polysaccharide biosynthetic process
I6K52_RS13750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K52_RS13755	COG0456	acetyltransferase
I6K52_RS13760	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K52_RS13765	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K52_RS13770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K52_RS13775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K52_RS13785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K52_RS13790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K52_RS13795	COG3118	belongs to the thioredoxin family
I6K52_RS13820	COG1811	Na channel or pump
I6K52_RS13830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K52_RS13835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K52_RS13845	COG0583	DNA-binding transcription factor activity
I6K52_RS13850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K52_RS13865	COG3978	acetolactate synthase activity
I6K52_RS13890	COG3085	chromosome segregation
I6K52_RS13965	COG0583	DNA-binding transcription factor activity
I6K52_RS13980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K52_RS13995	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K52_RS14000	COG2207	Transcriptional regulator
I6K52_RS14010	COG0371	Dehydrogenase
I6K52_RS14015	COG0697	spore germination
I6K52_RS14025	COG0583	DNA-binding transcription factor activity
I6K52_RS14035	COG0737	Belongs to the 5'-nucleotidase family
I6K52_RS14045	COG0460	homoserine dehydrogenase
I6K52_RS14045	COG0527	aspartate kinase activity
I6K52_RS14050	COG0626	cystathionine gamma-synthase activity
I6K52_RS14065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K52_RS14070	COG1609	Transcriptional regulator
I6K52_RS14075	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K52_RS14090	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K52_RS14110	COG3678	ATP-independent chaperone mediated protein folding
I6K52_RS14115	COG0745	RESPONSE REGULATOR receiver
I6K52_RS14120	COG2205	protein histidine kinase activity
I6K52_RS14125	COG2258	MOSC domain
I6K52_RS14130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K52_RS14170	COG1129	ABC transporter
I6K52_RS14175	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS14180	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS14185	COG1454	alcohol dehydrogenase
I6K52_RS14195	COG2211	Major facilitator Superfamily
I6K52_RS14255	COG0205	6-phosphofructokinase activity
I6K52_RS14275	COG0437	4 iron, 4 sulfur cluster binding
I6K52_RS14280	COG2864	formate dehydrogenase
I6K52_RS14295	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K52_RS14305	COG0456	acetyltransferase
I6K52_RS14320	COG1011	Hydrolase
I6K52_RS14335	COG3852	Histidine kinase
I6K52_RS14350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K52_RS14370	COG0204	Acyl-transferase
I6K52_RS14380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K52_RS14385	COG3084	Protein conserved in bacteria
I6K52_RS14395	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K52_RS14420	COG2186	Transcriptional regulator
I6K52_RS14425	COG0477	Major facilitator Superfamily
I6K52_RS14430	COG1609	Transcriptional regulator
I6K52_RS14435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K52_RS14445	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS14450	COG1129	ABC transporter
I6K52_RS14480	COG1522	sequence-specific DNA binding
I6K52_RS14485	COG0716	FMN binding
I6K52_RS14500	COG3312	ion transport
I6K52_RS14550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K52_RS14555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K52_RS14560	COG0573	inorganic phosphate transmembrane transporter activity
I6K52_RS14565	COG0581	inorganic phosphate transmembrane transporter activity
I6K52_RS14570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K52_RS14575	COG0704	Plays a role in the regulation of phosphate uptake
I6K52_RS14585	COG2382	esterase
I6K52_RS14590	COG0363	glucosamine-6-phosphate deaminase activity
I6K52_RS14595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K52_RS14600	COG2252	PERMEase
I6K52_RS14605	COG0431	NADPH-dependent FMN reductase
I6K52_RS14610	COG2091	lysine biosynthetic process via aminoadipic acid
I6K52_RS14640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K52_RS14670	COG0187	DNA topoisomerase II activity
I6K52_RS14675	COG0561	phosphatase activity
I6K52_RS14690	COG2186	Transcriptional regulator
I6K52_RS14695	COG3734	2-keto-3-deoxy-galactonokinase
I6K52_RS14700	COG0800	Aldolase
I6K52_RS14710	COG2271	Major facilitator Superfamily
I6K52_RS14715	COG0823	Involved in the tonB-independent uptake of proteins
I6K52_RS14720	COG5645	(Lipo)protein
I6K52_RS14735	COG3645	SOS response
I6K52_RS14745	COG2188	Transcriptional regulator
I6K52_RS14760	COG2149	membrane
I6K52_RS14780	COG2610	gluconate transmembrane transporter activity
I6K52_RS14790	COG0583	DNA-binding transcription factor activity
I6K52_RS14795	COG2814	Major facilitator Superfamily
I6K52_RS14825	COG0028	Belongs to the TPP enzyme family
I6K52_RS14830	COG0440	acetolactate synthase activity
I6K52_RS14835	COG2197	response regulator
I6K52_RS14845	COG2271	Major facilitator Superfamily
I6K52_RS14895	COG2188	Transcriptional regulator
I6K52_RS14920	COG4580	involved in the transport of maltose and maltodextrins
I6K52_RS14925	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K52_RS14930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS14930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS14940	COG1609	Transcriptional regulator
I6K52_RS14950	COG3384	dioxygenase
I6K52_RS14955	COG0583	DNA-binding transcription factor activity
I6K52_RS14960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K52_RS14965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K52_RS14970	COG2828	Protein conserved in bacteria
I6K52_RS14985	COG0697	spore germination
I6K52_RS14990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS14990	COG1263	PTS System
I6K52_RS15000	COG2814	Major facilitator Superfamily
I6K52_RS15010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K52_RS15035	COG1309	transcriptional regulator
I6K52_RS15045	COG0583	DNA-binding transcription factor activity
I6K52_RS15070	COG1464	Belongs to the NlpA lipoprotein family
I6K52_RS15085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K52_RS15095	COG1064	alcohol dehydrogenase
I6K52_RS15125	COG2211	Major facilitator Superfamily
I6K52_RS15130	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K52_RS15140	COG1486	melibiose metabolic process
I6K52_RS15145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS15145	COG1263	PTS System
I6K52_RS15150	COG2982	Protein involved in outer membrane biogenesis
I6K52_RS15155	COG2233	PERMEase
I6K52_RS15160	COG0786	glutamate:sodium symporter activity
I6K52_RS15180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K52_RS15205	COG3152	Membrane
I6K52_RS15215	COG1494	fructose-1,6-bisphosphatase
I6K52_RS15220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K52_RS15225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K52_RS15230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K52_RS15250	COG2860	membrane
I6K52_RS15260	COG2169	Transcriptional regulator
I6K52_RS15260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K52_RS15265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K52_RS15270	COG1561	YicC-like family, N-terminal region
I6K52_RS15290	COG1131	(ABC) transporter
I6K52_RS15295	COG0842	Transport permease protein
I6K52_RS15325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K52_RS15360	COG1519	Transferase
I6K52_RS15365	COG1216	Glycosyl transferase, family 2
I6K52_RS15370	COG0438	transferase activity, transferring glycosyl groups
I6K52_RS15380	COG0859	PFAM glycosyl transferase family 9
I6K52_RS15405	COG0859	PFAM glycosyl transferase family 9
I6K52_RS15420	COG0156	8-amino-7-oxononanoate synthase activity
I6K52_RS15430	COG0463	Glycosyl transferase, family 2
I6K52_RS15435	COG2861	carbohydrate metabolic process
I6K52_RS15440	COG4942	peptidase
I6K52_RS15450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K52_RS15455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K52_RS15475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K52_RS15485	COG2186	Transcriptional regulator
I6K52_RS15505	COG3722	fumarate hydratase activity
I6K52_RS15525	COG1566	PFAM secretion protein HlyD family protein
I6K52_RS15530	COG0625	glutathione transferase activity
I6K52_RS15540	COG3276	selenocysteine insertion sequence binding
I6K52_RS15545	COG1414	Transcriptional regulator
I6K52_RS15550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K52_RS15555	COG3977	Valine--pyruvate aminotransferase
I6K52_RS15560	COG0366	Alpha amylase catalytic
I6K52_RS15565	COG2992	FlgJ-related protein
I6K52_RS15570	COG1609	Transcriptional regulator
I6K52_RS15570	COG2207	Transcriptional regulator
I6K52_RS15575	COG4214	carbohydrate transport
I6K52_RS15585	COG4213	ABC transporter substrate-binding protein
I6K52_RS15600	COG4682	membrane
I6K52_RS15605	COG4682	membrane
I6K52_RS15610	COG3274	enterobacterial common antigen metabolic process
I6K52_RS15640	COG1278	Cold shock
I6K52_RS15645	COG2944	sequence-specific DNA binding
I6K52_RS15650	COG2814	Major facilitator Superfamily
I6K52_RS15670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K52_RS15680	COG1609	Transcriptional regulator
I6K52_RS15685	COG2885	chlorophyll binding
I6K52_RS15690	COG0243	molybdopterin cofactor binding
I6K52_RS15695	COG0456	acetyltransferase
I6K52_RS15700	COG2818	Glycosylase
I6K52_RS15705	COG5571	outer membrane autotransporter
I6K52_RS15710	COG2223	nitrite transmembrane transporter activity
I6K52_RS15740	COG0747	negative chemotaxis
I6K52_RS15745	COG0601	transmembrane transport
I6K52_RS15750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K52_RS15755	COG0444	Belongs to the ABC transporter superfamily
I6K52_RS15760	COG4608	Belongs to the ABC transporter superfamily
I6K52_RS15775	COG2894	cell division
I6K52_RS15785	COG1215	transferase activity, transferring glycosyl groups
I6K52_RS15790	COG0457	Tetratricopeptide repeat
I6K52_RS15805	COG2194	sulfuric ester hydrolase activity
I6K52_RS15835	COG1215	transferase activity, transferring glycosyl groups
I6K52_RS15840	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K52_RS15845	COG0457	Tetratricopeptide repeat
I6K52_RS15845	COG3118	belongs to the thioredoxin family
I6K52_RS15850	COG2200	EAL domain
I6K52_RS15850	COG2199	diguanylate cyclase activity
I6K52_RS15860	COG0612	Peptidase, M16
I6K52_RS15870	COG2982	Protein involved in outer membrane biogenesis
I6K52_RS15875	COG0477	Major facilitator Superfamily
I6K52_RS15880	COG1295	ribonuclease BN
I6K52_RS15885	COG0583	DNA-binding transcription factor activity
I6K52_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS15895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K52_RS15905	COG1454	alcohol dehydrogenase
I6K52_RS15915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K52_RS15920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K52_RS15945	COG0589	response to stress
I6K52_RS15955	COG0306	phosphate transporter
I6K52_RS15960	COG2081	HI0933 family
I6K52_RS15965	COG2239	Acts as a magnesium transporter
I6K52_RS15975	COG1124	(ABC) transporter
I6K52_RS15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K52_RS15990	COG0601	transmembrane transport
I6K52_RS15995	COG0747	negative chemotaxis
I6K52_RS16005	COG3479	Phenolic acid decarboxylase
I6K52_RS16045	COG0628	permease
I6K52_RS16050	COG0477	Major facilitator Superfamily
I6K52_RS16060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K52_RS16075	COG3714	YhhN family
I6K52_RS16085	COG3776	membrane
I6K52_RS16090	COG0742	ribosomal rna small subunit methyltransferase
I6K52_RS16095	COG0552	protein localization to endoplasmic reticulum
I6K52_RS16100	COG2884	Cell division ATP-binding protein ftsE
I6K52_RS16105	COG2177	Part of the ABC transporter FtsEX involved in
I6K52_RS16120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K52_RS16130	COG0683	leucine binding
I6K52_RS16140	COG0683	leucine binding
I6K52_RS16145	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS16195	COG0584	glycerophosphoryl diester phosphodiesterase
I6K52_RS16205	COG0405	Gamma-glutamyltransferase
I6K52_RS16210	COG1247	-acetyltransferase
I6K52_RS16220	COG0673	inositol 2-dehydrogenase activity
I6K52_RS16225	COG1741	Belongs to the pirin family
I6K52_RS16230	COG1609	Transcriptional regulator
I6K52_RS16235	COG3265	gluconokinase activity
I6K52_RS16240	COG2610	gluconate transmembrane transporter activity
I6K52_RS16250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K52_RS16275	COG0058	SHG alpha-glucan phosphorylase activity
I6K52_RS16290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K52_RS16305	COG1349	DNA-binding transcription factor activity
I6K52_RS16315	COG0058	SHG alpha-glucan phosphorylase activity
I6K52_RS16320	COG1640	4-alpha-glucanotransferase
I6K52_RS16325	COG2610	gluconate transmembrane transporter activity
I6K52_RS16335	COG1040	competence protein
I6K52_RS16360	COG1918	ferrous iron import across plasma membrane
I6K52_RS16365	COG2183	response to ionizing radiation
I6K52_RS16370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K52_RS16395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K52_RS16400	COG1011	Hydrolase
I6K52_RS16410	COG0494	nUDIX hydrolase
I6K52_RS16415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K52_RS16440	COG4796	Type ii and iii secretion system protein
I6K52_RS16455	COG3266	domain, Protein
I6K52_RS16460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K52_RS16465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K52_RS16490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K52_RS16495	COG0402	S-adenosylhomocysteine deaminase activity
I6K52_RS16500	COG0738	Major facilitator superfamily
I6K52_RS16525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K52_RS16530	COG1289	transmembrane transporter activity
I6K52_RS16540	COG1765	OsmC-like protein
I6K52_RS16545	COG3954	Phosphoribulokinase
I6K52_RS16555	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K52_RS16560	COG0488	(ABC) transporter
I6K52_RS16575	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K52_RS16580	COG1047	Peptidyl-prolyl cis-trans
I6K52_RS16590	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K52_RS16595	COG2964	Protein conserved in bacteria
I6K52_RS16650	COG0051	transcription antitermination factor activity, RNA binding
I6K52_RS16675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K52_RS16690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K52_RS16755	COG0201	protein transport
I6K52_RS16780	COG0202	RNA polymerase activity
I6K52_RS16795	COG0789	Transcriptional regulator
I6K52_RS16800	COG3036	rescue of stalled ribosome
I6K52_RS16830	COG0758	DNA mediated transformation
I6K52_RS16840	COG0551	DNA topoisomerase type I activity
I6K52_RS16860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K52_RS16895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K52_RS16900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS16905	COG1309	transcriptional regulator
I6K52_RS16925	COG4145	pantothenate transmembrane transporter activity
I6K52_RS16930	COG3924	membrane
I6K52_RS16935	COG0439	Biotin carboxylase
I6K52_RS16940	COG0511	ligase activity, forming carbon-carbon bonds
I6K52_RS16965	COG2199	diguanylate cyclase activity
I6K52_RS16965	COG2200	EAL domain
I6K52_RS16970	COG1077	Cell shape determining protein MreB Mrl
I6K52_RS16975	COG1792	Involved in formation and maintenance of cell shape
I6K52_RS16980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K52_RS16990	COG1530	ribonuclease E activity
I6K52_RS16995	COG3164	Protein of unknown function
I6K52_RS17000	COG0312	modulator of DNA gyrase
I6K52_RS17005	COG0583	DNA-binding transcription factor activity
I6K52_RS17020	COG1289	transmembrane transporter activity
I6K52_RS17025	COG2732	(Barnase) inhibitor
I6K52_RS17050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K52_RS17055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K52_RS17060	COG3105	Protein conserved in bacteria
I6K52_RS17065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K52_RS17085	COG0625	glutathione transferase activity
I6K52_RS17090	COG2969	positive regulation of protein catabolic process
I6K52_RS17100	COG0493	'glutamate synthase
I6K52_RS17105	COG0067	glutamate synthase
I6K52_RS17105	COG0069	glutamate synthase activity
I6K52_RS17105	COG0070	glutamate synthase
I6K52_RS17110	COG1242	4 iron, 4 sulfur cluster binding
I6K52_RS17115	COG2271	Major facilitator Superfamily
I6K52_RS17120	COG1063	alcohol dehydrogenase
I6K52_RS17125	COG1312	Catalyzes the dehydration of D-mannonate
I6K52_RS17130	COG0784	Response regulator, receiver
I6K52_RS17130	COG2198	Histidine kinase
I6K52_RS17130	COG5002	protein histidine kinase activity
I6K52_RS17135	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K52_RS17140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K52_RS17145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS17155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS17160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K52_RS17165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K52_RS17170	COG1137	ATPase activity
I6K52_RS17175	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K52_RS17180	COG3117	lipopolysaccharide transmembrane transporter activity
I6K52_RS17185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K52_RS17195	COG0530	calcium, potassium:sodium antiporter activity
I6K52_RS17200	COG1127	ABC transporter
I6K52_RS17205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K52_RS17210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K52_RS17215	COG2854	intermembrane phospholipid transfer
I6K52_RS17220	COG3113	response to antibiotic
I6K52_RS17225	COG5007	Belongs to the BolA IbaG family
I6K52_RS17235	COG3423	Transcriptional regulator
I6K52_RS17240	COG0142	geranyltranstransferase activity
I6K52_RS17255	COG0697	spore germination
I6K52_RS17265	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K52_RS17275	COG1534	Rna-binding protein
I6K52_RS17285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K52_RS17290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K52_RS17300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K52_RS17340	COG0195	Participates in both transcription termination and antitermination
I6K52_RS17385	COG0814	amino acid
I6K52_RS17410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6K52_RS17455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K52_RS17460	COG0826	peptidase U32
I6K52_RS17465	COG0826	peptidase U32
I6K52_RS17470	COG3154	lipid carrier protein
I6K52_RS17475	COG3153	acetyltransferase
I6K52_RS17490	COG0693	protein deglycase activity
I6K52_RS17495	COG0702	epimerase
I6K52_RS17500	COG0701	Predicted permease
I6K52_RS17505	COG2823	Periplasmic or secreted lipoprotein
I6K52_RS17525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K52_RS17540	COG1063	alcohol dehydrogenase
I6K52_RS17545	COG3775	system Galactitol-specific IIC component
I6K52_RS17550	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K52_RS17555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS17565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS17565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS17570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS17570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K52_RS17570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K52_RS17575	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K52_RS17585	COG1349	DNA-binding transcription factor activity
I6K52_RS17590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K52_RS17595	COG2721	sulfolactate sulfo-lyase activity
I6K52_RS17600	COG2271	Major facilitator Superfamily
I6K52_RS17610	COG2084	Dehydrogenase
I6K52_RS17615	COG1929	Belongs to the glycerate kinase type-1 family
I6K52_RS17640	COG1741	Belongs to the pirin family
I6K52_RS17645	COG0583	DNA-binding transcription factor activity
I6K52_RS17650	COG3152	Membrane
I6K52_RS17655	COG0435	Glutathione S-transferase
I6K52_RS17660	COG2259	Doxx family
I6K52_RS17670	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K52_RS17675	COG4575	ribosome binding
I6K52_RS17680	COG1422	Protein of unknown function (DUF1090)
I6K52_RS17690	COG0586	Pfam SNARE associated Golgi protein
I6K52_RS17695	COG2186	Transcriptional regulator
I6K52_RS17700	COG2271	Major facilitator Superfamily
I6K52_RS17710	COG2721	sulfolactate sulfo-lyase activity
I6K52_RS17725	COG0861	Integral membrane protein TerC family
I6K52_RS17730	COG0673	inositol 2-dehydrogenase activity
I6K52_RS17735	COG1451	nucleotide metabolic process
I6K52_RS17755	COG1902	pentaerythritol trinitrate reductase activity
I6K52_RS17755	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K52_RS17805	COG1695	Transcriptional regulator
I6K52_RS17810	COG2375	cellular response to nickel ion
I6K52_RS17825	COG1461	Dihydroxyacetone kinase
I6K52_RS17830	COG2376	Dihydroxyacetone kinase
I6K52_RS17900	COG3247	response to pH
I6K52_RS17910	COG2205	protein histidine kinase activity
I6K52_RS17910	COG2198	Histidine kinase
I6K52_RS17910	COG0784	Response regulator, receiver
I6K52_RS17910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS17915	COG2197	response regulator
I6K52_RS17940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K52_RS17945	COG0358	DNA primase activity
I6K52_RS17950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K52_RS18015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K52_RS18030	COG4991	sh3 domain protein
I6K52_RS18035	COG3025	triphosphatase activity
I6K52_RS18060	COG2960	long-chain fatty acid transporting porin activity
I6K52_RS18075	COG3384	dioxygenase
I6K52_RS18080	COG0754	glutathionylspermidine amidase activity
I6K52_RS18095	COG0494	nUDIX hydrolase
I6K52_RS18100	COG3151	Protein conserved in bacteria
I6K52_RS18105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K52_RS18110	COG3150	esterase
I6K52_RS18120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K52_RS18125	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K52_RS18130	COG0642	Histidine kinase
I6K52_RS18140	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K52_RS18145	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K52_RS18150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K52_RS18155	COG0204	Acyl-transferase
I6K52_RS18160	COG2132	Multicopper oxidase
I6K52_RS18165	COG1032	radical SAM domain protein
I6K52_RS18175	COG0656	L-ascorbic acid biosynthetic process
I6K52_RS18180	COG1979	alcohol dehydrogenase
I6K52_RS18185	COG2207	Transcriptional regulator
I6K52_RS18190	COG0586	Pfam SNARE associated Golgi protein
I6K52_RS18195	COG0626	cystathionine gamma-synthase activity
I6K52_RS18205	COG0848	biopolymer transport protein
I6K52_RS18210	COG2211	Major facilitator Superfamily
I6K52_RS18235	COG0625	glutathione transferase activity
I6K52_RS18250	COG0754	glutathionylspermidine amidase activity
I6K52_RS18255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K52_RS18280	COG0626	cystathionine gamma-synthase activity
I6K52_RS18295	COG1811	Na channel or pump
I6K52_RS18300	COG1982	Orn Lys Arg decarboxylase major
I6K52_RS18305	COG2211	Major facilitator Superfamily
I6K52_RS18320	COG1194	a g-specific adenine glycosylase
I6K52_RS18330	COG3171	Protein conserved in bacteria
I6K52_RS18340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K52_RS18355	COG0762	integral membrane protein
I6K52_RS18360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K52_RS18365	COG2805	Type II/IV secretion system protein
I6K52_RS18385	COG0189	ligase activity
I6K52_RS18390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K52_RS18395	COG2356	endonuclease I
I6K52_RS18405	COG2814	Major facilitator Superfamily
I6K52_RS18440	COG2146	nitrite reductase [NAD(P)H] activity
I6K52_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS18460	COG1414	Transcriptional regulator
I6K52_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS18495	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K52_RS18515	COG0501	Belongs to the peptidase M48B family
I6K52_RS18520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K52_RS18535	COG0191	fructose-bisphosphate aldolase activity
I6K52_RS18540	COG0668	transmembrane transport
I6K52_RS18550	COG2968	Membrane
I6K52_RS18565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K52_RS18570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K52_RS18590	COG0006	proline dipeptidase activity
I6K52_RS18595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K52_RS18600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K52_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS18630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K52_RS18650	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS18655	COG1737	Transcriptional regulator
I6K52_RS18665	COG1272	protein, Hemolysin III
I6K52_RS18675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K52_RS18685	COG0716	FMN binding
I6K52_RS18690	COG4974	Belongs to the 'phage' integrase family
I6K52_RS18700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K52_RS18720	COG4942	peptidase
I6K52_RS18730	COG2814	Major facilitator Superfamily
I6K52_RS18745	COG0667	Aldo Keto reductase
I6K52_RS18785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K52_RS18790	COG1393	Belongs to the ArsC family
I6K52_RS18810	COG1538	Outer membrane efflux protein
I6K52_RS18815	COG1289	transmembrane transporter activity
I6K52_RS18830	COG3592	Divergent 4Fe-4S mono-cluster
I6K52_RS18835	COG2388	GCN5-related N-acetyl-transferase
I6K52_RS18845	COG3539	Fimbrial protein
I6K52_RS18850	COG3539	Fimbrial protein
I6K52_RS18855	COG3539	Fimbrial protein
I6K52_RS18860	COG3188	usher protein
I6K52_RS18865	COG3121	Chaperone
I6K52_RS18870	COG3539	Fimbrial protein
I6K52_RS18880	COG4974	Belongs to the 'phage' integrase family
I6K52_RS18885	COG0582	viral genome integration into host DNA
I6K52_RS18890	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K52_RS18895	COG1846	Transcriptional regulator
I6K52_RS18900	COG0697	spore germination
I6K52_RS18950	COG0667	Aldo Keto reductase
I6K52_RS18955	COG0814	amino acid
I6K52_RS18970	COG0183	Belongs to the thiolase family
I6K52_RS18980	COG0823	Involved in the tonB-independent uptake of proteins
I6K52_RS18985	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS18990	COG2814	Major facilitator Superfamily
I6K52_RS19025	COG3842	ATPase activity
I6K52_RS19030	COG0395	ABC-type sugar transport system, permease component
I6K52_RS19035	COG1175	transmembrane transport
I6K52_RS19040	COG1917	Cupin 2, conserved barrel domain protein
I6K52_RS19045	COG1794	racemase activity, acting on amino acids and derivatives
I6K52_RS19050	COG0583	DNA-binding transcription factor activity
I6K52_RS19060	COG1609	Transcriptional regulator
I6K52_RS19065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS19070	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS19075	COG2186	Transcriptional regulator
I6K52_RS19085	COG1609	Transcriptional regulator
I6K52_RS19105	COG0667	Aldo Keto reductase
I6K52_RS19115	COG0861	Integral membrane protein TerC family
I6K52_RS19150	COG2165	general secretion pathway protein
I6K52_RS19155	COG4795	General secretion pathway protein
I6K52_RS19165	COG4967	type IV pilus modification protein PilV
I6K52_RS19170	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K52_RS19175	COG1025	Belongs to the peptidase M16 family
I6K52_RS19180	COG1074	ATP-dependent DNA helicase activity
I6K52_RS19185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K52_RS19195	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K52_RS19195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K52_RS19200	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K52_RS19205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K52_RS19235	COG4656	Part of a membrane complex involved in electron transport
I6K52_RS19240	COG1454	alcohol dehydrogenase
I6K52_RS19240	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS19270	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K52_RS19435	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K52_RS19440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K52_RS19445	COG2166	iron-sulfur cluster assembly
I6K52_RS19450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K52_RS19460	COG0583	DNA-binding transcription factor activity
I6K52_RS19465	COG2363	Small membrane protein
I6K52_RS19475	COG1349	DNA-binding transcription factor activity
I6K52_RS19495	COG0738	Major facilitator superfamily
I6K52_RS19500	COG0235	Class ii aldolase
I6K52_RS19505	COG1454	alcohol dehydrogenase
I6K52_RS19520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K52_RS19535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K52_RS19540	COG2011	ABC-type metal ion transport system permease component
I6K52_RS19545	COG1464	Belongs to the NlpA lipoprotein family
I6K52_RS19550	COG0477	Major facilitator Superfamily
I6K52_RS19560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K52_RS19565	COG1760	l-serine dehydratase
I6K52_RS19570	COG0814	amino acid
I6K52_RS19575	COG1611	Belongs to the LOG family
I6K52_RS19590	COG3098	single-species biofilm formation
I6K52_RS19595	COG0564	pseudouridine synthase activity
I6K52_RS19600	COG0716	FMN binding
I6K52_RS19605	COG2271	Major facilitator Superfamily
I6K52_RS19610	COG4948	Mandelate Racemase Muconate Lactonizing
I6K52_RS19615	COG4948	Mandelate Racemase Muconate Lactonizing
I6K52_RS19620	COG1929	Belongs to the glycerate kinase type-1 family
I6K52_RS19625	COG3850	Histidine kinase
I6K52_RS19625	COG4999	Histidine kinase
I6K52_RS19625	COG2205	protein histidine kinase activity
I6K52_RS19625	COG3437	response regulator, receiver
I6K52_RS19635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K52_RS19640	COG3956	TIGRFAM MazG family protein
I6K52_RS19660	COG0602	queuosine metabolic process
I6K52_RS19665	COG0720	synthase
I6K52_RS19685	COG2234	aminopeptidase activity
I6K52_RS19745	COG4942	peptidase
I6K52_RS19745	COG1388	LysM domain
I6K52_RS19750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K52_RS19775	COG0163	prenyltransferase activity
I6K52_RS19780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K52_RS19820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS19825	COG4558	Periplasmic binding protein
I6K52_RS19830	COG3720	iron ion transport
I6K52_RS19850	COG0679	Auxin Efflux Carrier
I6K52_RS19865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K52_RS19870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K52_RS19875	COG1121	(ABC) transporter
I6K52_RS19885	COG1609	Transcriptional regulator
I6K52_RS19890	COG1940	carbohydrate kinase activity
I6K52_RS19895	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K52_RS19900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS19905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS19910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K52_RS19915	COG4580	involved in the transport of maltose and maltodextrins
I6K52_RS19925	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS19935	COG0309	Hydrogenase expression formation protein (HypE)
I6K52_RS19940	COG0409	Hydrogenase expression formation protein
I6K52_RS19945	COG0298	carbon dioxide binding
I6K52_RS19950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K52_RS19965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K52_RS19970	COG0651	ATP synthesis coupled electron transport
I6K52_RS19975	COG0650	Formate hydrogenlyase subunit 4
I6K52_RS19980	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K52_RS19980	COG3261	NADH dehydrogenase
I6K52_RS19985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K52_RS19990	COG3260	NADH ubiquinone oxidoreductase 20
I6K52_RS20000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K52_RS20010	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS20015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS20015	COG1263	PTS System
I6K52_RS20020	COG1609	Transcriptional regulator
I6K52_RS20025	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K52_RS20030	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K52_RS20035	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K52_RS20060	COG1349	DNA-binding transcription factor activity
I6K52_RS20065	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS20070	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS20080	COG3732	PTS system glucitol sorbitol-specific
I6K52_RS20085	COG3730	PTS system glucitol sorbitol-specific
I6K52_RS20090	COG2951	lytic endotransglycosylase activity
I6K52_RS20095	COG1121	(ABC) transporter
I6K52_RS20100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K52_RS20105	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K52_RS20110	COG1546	Belongs to the CinA family
I6K52_RS20130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K52_RS20160	COG2823	Periplasmic or secreted lipoprotein
I6K52_RS20165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K52_RS20170	COG1238	metal cluster binding
I6K52_RS20190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K52_RS20195	COG2814	Major facilitator Superfamily
I6K52_RS20200	COG1566	PFAM secretion protein HlyD family protein
I6K52_RS20205	COG1846	Transcriptional regulator
I6K52_RS20215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K52_RS20225	COG4176	ABC-type proline glycine betaine transport system permease component
I6K52_RS20240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K52_RS20250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K52_RS20255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K52_RS20260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K52_RS20265	COG4575	ribosome binding
I6K52_RS20280	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K52_RS20295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K52_RS20300	COG0640	Transcriptional regulator
I6K52_RS20310	COG0583	DNA-binding transcription factor activity
I6K52_RS20315	COG3284	Transcriptional regulator
I6K52_RS20325	COG3539	Fimbrial protein
I6K52_RS20350	COG3188	usher protein
I6K52_RS20355	COG3121	Chaperone
I6K52_RS20360	COG3539	Fimbrial protein
I6K52_RS20365	COG2197	response regulator
I6K52_RS20380	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS20390	COG0235	Class ii aldolase
I6K52_RS20395	COG1126	abc transporter atp-binding protein
I6K52_RS20400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS20435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS20440	COG3708	Transcriptional regulator
I6K52_RS20440	COG2207	Transcriptional regulator
I6K52_RS20470	COG2867	negative regulation of translational initiation
I6K52_RS20485	COG0497	DNA recombination
I6K52_RS20500	COG4536	flavin adenine dinucleotide binding
I6K52_RS20505	COG4137	Cytochrome C assembly protein
I6K52_RS20510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K52_RS20665	COG4695	Portal protein
I6K52_RS20750	COG2885	chlorophyll binding
I6K52_RS20755	COG2199	diguanylate cyclase activity
I6K52_RS20765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K52_RS20770	COG1605	Chorismate mutase
I6K52_RS20770	COG0287	Prephenate dehydrogenase
I6K52_RS20780	COG0077	Prephenate dehydratase
I6K52_RS20780	COG1605	Chorismate mutase
I6K52_RS20790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K52_RS20795	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K52_RS20810	COG0542	response to heat
I6K52_RS20835	COG0477	Major facilitator Superfamily
I6K52_RS20840	COG5544	Lipoprotein
I6K52_RS20845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K52_RS20855	COG3148	PFAM DTW domain containing protein
I6K52_RS20860	COG3118	belongs to the thioredoxin family
I6K52_RS20865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K52_RS20880	COG0513	Belongs to the DEAD box helicase family
I6K52_RS20890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K52_RS20905	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K52_RS20910	COG3026	antisigma factor binding
I6K52_RS20915	COG3086	response to oxidative stress
I6K52_RS20925	COG0681	Belongs to the peptidase S26 family
I6K52_RS20945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K52_RS20955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K52_RS20960	COG1737	Transcriptional regulator
I6K52_RS20965	COG0560	Phosphoserine phosphatase
I6K52_RS20980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K52_RS20980	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K52_RS20985	COG2205	protein histidine kinase activity
I6K52_RS20990	COG3170	Tfp pilus assembly protein FimV
I6K52_RS20995	COG2204	response regulator
I6K52_RS21000	COG0347	Belongs to the P(II) protein family
I6K52_RS21005	COG1017	nitric oxide dioxygenase activity
I6K52_RS21005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K52_RS21015	COG2259	Doxx family
I6K52_RS21020	COG1940	carbohydrate kinase activity
I6K52_RS21025	COG0457	Tetratricopeptide repeat
I6K52_RS21030	COG2814	Major facilitator Superfamily
I6K52_RS21030	COG0477	Major facilitator Superfamily
I6K52_RS21035	COG2017	converts alpha-aldose to the beta-anomer
I6K52_RS21040	COG2814	Major facilitator Superfamily
I6K52_RS21045	COG3711	transcriptional antiterminator
I6K52_RS21050	COG3683	transport system, periplasmic component
I6K52_RS21055	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K52_RS21085	COG0822	iron-sulfur transferase activity
I6K52_RS21105	COG0633	Ferredoxin
I6K52_RS21110	COG2975	iron-sulfur cluster assembly
I6K52_RS21130	COG2897	thiosulfate sulfurtransferase activity
I6K52_RS21135	COG2373	Large extracellular alpha-helical protein
I6K52_RS21140	COG4953	penicillin-binding protein 1C
I6K52_RS21170	COG2976	Protein conserved in bacteria
I6K52_RS21190	COG1645	bacterial-type flagellum-dependent swarming motility
I6K52_RS21200	COG0517	IMP dehydrogenase activity
I6K52_RS21200	COG0516	GMP reductase activity
I6K52_RS21215	COG0641	radical SAM
I6K52_RS21235	COG2200	EAL domain
I6K52_RS21250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K52_RS21265	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS21275	COG2233	PERMEase
I6K52_RS21290	COG1393	Belongs to the ArsC family
I6K52_RS21295	COG4783	chaperone-mediated protein folding
I6K52_RS21305	COG0628	permease
I6K52_RS21310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K52_RS21315	COG2716	regulation of RNA biosynthetic process
I6K52_RS21325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K52_RS21335	COG2321	neutral zinc metallopeptidase
I6K52_RS21340	COG1444	tRNA N-acetyltransferase activity
I6K52_RS21345	COG0400	carboxylic ester hydrolase activity
I6K52_RS21360	COG1393	Belongs to the ArsC family
I6K52_RS21370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K52_RS21375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K52_RS21375	COG0493	'glutamate synthase
I6K52_RS21385	COG5342	invasion associated locus B
I6K52_RS21390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K52_RS21395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K52_RS21405	COG4810	utilization protein
I6K52_RS21495	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K52_RS21515	COG2837	iron assimilation
I6K52_RS21525	COG4150	thiosulfate binding
I6K52_RS21530	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K52_RS21535	COG4208	sulfate ABC transporter
I6K52_RS21540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K52_RS21550	COG4319	ketosteroid isomerase
I6K52_RS21585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K52_RS21605	COG3530	Putative quorum-sensing-regulated virulence factor
I6K52_RS21610	COG0385	Bile acid
I6K52_RS21615	COG0583	DNA-binding transcription factor activity
I6K52_RS21650	COG3415	Transposase
I6K52_RS21655	COG3415	Transposase
I6K52_RS21670	COG2200	EAL domain
I6K52_RS21670	COG2199	diguanylate cyclase activity
I6K52_RS21675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K52_RS21690	COG0667	Aldo Keto reductase
I6K52_RS21695	COG3961	Belongs to the TPP enzyme family
I6K52_RS21710	COG3279	Response regulator of the LytR AlgR family
I6K52_RS21715	COG3275	phosphorelay sensor kinase activity
I6K52_RS21730	COG0436	Aminotransferase
I6K52_RS21740	COG2807	transmembrane transport
I6K52_RS21745	COG0590	tRNA wobble adenosine to inosine editing
I6K52_RS21750	COG0583	DNA-binding transcription factor activity
I6K52_RS21770	COG2116	formate transmembrane transporter activity
I6K52_RS21775	COG2853	Lipoprotein
I6K52_RS21785	COG3691	Protein conserved in bacteria
I6K52_RS21800	COG2062	phosphohistidine phosphatase, SixA
I6K52_RS21825	COG0730	response to heat
I6K52_RS21830	COG3101	peptidyl-lysine hydroxylation
I6K52_RS21845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K52_RS21865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K52_RS21875	COG0586	Pfam SNARE associated Golgi protein
I6K52_RS21885	COG0285	dihydrofolate synthase activity
I6K52_RS21890	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K52_RS21895	COG1286	toxin biosynthetic process
I6K52_RS21900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K52_RS21905	COG3829	transcription factor binding
I6K52_RS21915	COG0531	amino acid
I6K52_RS21920	COG3457	Alanine racemase
I6K52_RS21925	COG0833	amino acid
I6K52_RS21930	COG0163	prenyltransferase activity
I6K52_RS21955	COG4160	amino acid transport
I6K52_RS21960	COG4598	ABC transporter
I6K52_RS21975	COG1090	epimerase
I6K52_RS21980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K52_RS21985	COG0625	glutathione transferase activity
I6K52_RS21990	COG0625	glutathione transferase activity
I6K52_RS21995	COG0622	Phosphoesterase
I6K52_RS22000	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K52_RS22005	COG0857	belongs to the CobB CobQ family
I6K52_RS22005	COG0280	phosphate acetyltransferase
I6K52_RS22025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K52_RS22030	COG0490	domain, Protein
I6K52_RS22030	COG0471	metal ion transport
I6K52_RS22040	COG0436	Aminotransferase
I6K52_RS22045	COG0583	DNA-binding transcription factor activity
I6K52_RS22090	COG0839	Belongs to the complex I subunit 6 family
I6K52_RS22100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K52_RS22105	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K52_RS22120	COG2153	protein acetylation
I6K52_RS22125	COG1169	isochorismate synthase
I6K52_RS22150	COG0318	PFAM AMP-dependent synthetase and ligase
I6K52_RS22160	COG5464	transposase or invertase
I6K52_RS22175	COG1414	Transcriptional regulator
I6K52_RS22185	COG2271	Major facilitator Superfamily
I6K52_RS22195	COG0247	lactate metabolic process
I6K52_RS22205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K52_RS22210	COG2271	Major facilitator Superfamily
I6K52_RS22215	COG0584	glycerophosphoryl diester phosphodiesterase
I6K52_RS22220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K52_RS22245	COG2205	protein histidine kinase activity
I6K52_RS22245	COG0784	Response regulator, receiver
I6K52_RS22255	COG2198	Histidine kinase
I6K52_RS22255	COG0642	Histidine kinase
I6K52_RS22270	COG2169	Transcriptional regulator
I6K52_RS22270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K52_RS22275	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K52_RS22280	COG4615	Cyclic peptide transporter
I6K52_RS22285	COG2239	Acts as a magnesium transporter
I6K52_RS22290	COG0659	secondary active sulfate transmembrane transporter activity
I6K52_RS22305	COG0628	permease
I6K52_RS22330	COG1349	DNA-binding transcription factor activity
I6K52_RS22335	COG0494	nUDIX hydrolase
I6K52_RS22355	COG1061	Type III restriction enzyme res subunit
I6K52_RS22360	COG1187	pseudouridine synthase activity
I6K52_RS22365	COG2814	Major facilitator Superfamily
I6K52_RS22375	COG4172	Belongs to the ABC transporter superfamily
I6K52_RS22380	COG4239	(ABC) transporter, permease
I6K52_RS22385	COG4174	ABC transporter (Permease)
I6K52_RS22390	COG4166	transmembrane transport
I6K52_RS22395	COG2200	EAL domain
I6K52_RS22400	COG0791	NLP P60 protein
I6K52_RS22405	COG0671	phosphoesterase, PA-phosphatase related
I6K52_RS22410	COG0523	cobalamin synthesis protein
I6K52_RS22415	COG0246	Mannitol dehydrogenase
I6K52_RS22420	COG1312	Catalyzes the dehydration of D-mannonate
I6K52_RS22440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS22440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS22445	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K52_RS22450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K52_RS22450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K52_RS22450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K52_RS22460	COG2855	membrane
I6K52_RS22465	COG0583	DNA-binding transcription factor activity
I6K52_RS22470	COG0833	amino acid
I6K52_RS22475	COG4771	TonB-dependent receptor
I6K52_RS22490	COG2311	Membrane
I6K52_RS22505	COG1129	ABC transporter
I6K52_RS22515	COG2949	membrane
I6K52_RS22525	COG1346	cytolysis
I6K52_RS22535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K52_RS22540	COG3659	wide pore channel activity
I6K52_RS22555	COG2723	6-phospho-beta-galactosidase activity
I6K52_RS22560	COG1538	Outer membrane efflux protein
I6K52_RS22565	COG0586	Pfam SNARE associated Golgi protein
I6K52_RS22575	COG1686	Belongs to the peptidase S11 family
I6K52_RS22585	COG0277	FAD linked oxidase domain protein
I6K52_RS22590	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K52_RS22595	COG1732	Glycine betaine
I6K52_RS22600	COG1174	glycine betaine transport
I6K52_RS22605	COG1125	glycine betaine transport
I6K52_RS22610	COG1174	glycine betaine transport
I6K52_RS22620	COG3275	phosphorelay sensor kinase activity
I6K52_RS22630	COG4807	Protein conserved in bacteria
I6K52_RS22650	COG5455	response to cobalt ion
I6K52_RS22655	COG0583	DNA-binding transcription factor activity
I6K52_RS22660	COG2252	PERMEase
I6K52_RS22670	COG0583	DNA-binding transcription factor activity
I6K52_RS22685	COG0351	phosphomethylpyrimidine kinase
I6K52_RS22690	COG1830	Aldolase
I6K52_RS22725	COG1070	Carbohydrate kinase
I6K52_RS22735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K52_RS22740	COG4948	Mandelate Racemase Muconate Lactonizing
I6K52_RS22745	COG0747	negative chemotaxis
I6K52_RS22750	COG0601	transmembrane transport
I6K52_RS22755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K52_RS22760	COG0444	Belongs to the ABC transporter superfamily
I6K52_RS22765	COG4608	Belongs to the ABC transporter superfamily
I6K52_RS22775	COG0826	peptidase U32
I6K52_RS22780	COG0745	RESPONSE REGULATOR receiver
I6K52_RS22785	COG2205	protein histidine kinase activity
I6K52_RS22810	COG1301	dicarboxylic acid transport
I6K52_RS22830	COG5002	protein histidine kinase activity
I6K52_RS22835	COG0443	Heat shock 70 kDa protein
I6K52_RS22840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K52_RS22855	COG2982	Protein involved in outer membrane biogenesis
I6K52_RS22860	COG1253	flavin adenine dinucleotide binding
I6K52_RS22900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K52_RS22910	COG1216	Glycosyl transferase, family 2
I6K52_RS22935	COG2327	Polysaccharide pyruvyl transferase
I6K52_RS22940	COG0463	Glycosyl transferase, family 2
I6K52_RS22995	COG0438	transferase activity, transferring glycosyl groups
I6K52_RS23000	COG1216	Glycosyl transferase, family 2
I6K52_RS23000	COG1442	glycosyl transferase family 8
I6K52_RS23010	COG0463	Glycosyl transferase, family 2
I6K52_RS23035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K52_RS23065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K52_RS23080	COG0531	amino acid
I6K52_RS23085	COG0640	Transcriptional regulator
I6K52_RS23090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K52_RS23095	COG2925	Exonuclease
I6K52_RS23110	COG1289	transmembrane transporter activity
I6K52_RS23130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K52_RS23140	COG1942	4-Oxalocrotonate Tautomerase
I6K52_RS23145	COG0583	DNA-binding transcription factor activity
I6K52_RS23150	COG0095	Lipoate-protein ligase
I6K52_RS23155	COG0477	Major facilitator Superfamily
I6K52_RS23165	COG5001	Diguanylate cyclase
I6K52_RS23165	COG3300	MHYT domain
I6K52_RS23175	COG3615	Tellurite resistance protein tehB
I6K52_RS23200	COG3706	GGDEF domain
I6K52_RS23220	COG0534	Mate efflux family protein
I6K52_RS23230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K52_RS23250	COG0604	alcohol dehydrogenase
I6K52_RS23255	COG1309	transcriptional regulator
I6K52_RS23260	COG0025	NhaP-type Na H and K H
I6K52_RS23310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K52_RS23320	COG1418	mRNA catabolic process
I6K52_RS23325	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K52_RS23330	COG3727	T/G mismatch-specific endonuclease activity
I6K52_RS23335	COG0697	spore germination
I6K52_RS23340	COG2354	Protein conserved in bacteria
I6K52_RS23370	COG0366	Alpha amylase catalytic
I6K52_RS23375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K52_RS23385	COG0765	amino acid transport
I6K52_RS23390	COG1126	abc transporter atp-binding protein
I6K52_RS23395	COG2197	response regulator
I6K52_RS23405	COG2197	response regulator
I6K52_RS23440	COG3318	Belongs to the UPF0149 family
I6K52_RS23440	COG3012	SEC-C Motif Domain Protein
I6K52_RS23445	COG0814	amino acid
I6K52_RS23455	COG1528	Iron-storage protein
I6K52_RS23470	COG0477	Major facilitator Superfamily
I6K52_RS23480	COG2211	Major facilitator Superfamily
I6K52_RS23490	COG1528	Iron-storage protein
I6K52_RS23500	COG1879	ABC-type sugar transport system periplasmic component
I6K52_RS23510	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K52_RS23535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K52_RS23545	COG3102	Protein conserved in bacteria
I6K52_RS23565	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K52_RS23570	COG1801	Protein of unknown function DUF72
I6K52_RS23575	COG1335	isochorismatase
I6K52_RS23585	COG0494	nUDIX hydrolase
I6K52_RS23610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K52_RS23620	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K52_RS23625	COG0739	heme binding
I6K52_RS23630	COG1560	Kdo2-lipid A biosynthetic process
I6K52_RS23640	COG1737	Transcriptional regulator
I6K52_RS23650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K52_RS23655	COG0129	dihydroxy-acid dehydratase activity
I6K52_RS23660	COG0800	Aldolase
I6K52_RS23670	COG3141	response to X-ray
I6K52_RS23675	COG2979	Protein of unknown function (DUF533)
I6K52_RS23680	COG1770	oligopeptidase
I6K52_RS23685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K52_RS23695	COG2372	response to copper ion
I6K52_RS23700	COG1276	copper resistance
I6K52_RS23715	COG2990	Protein conserved in bacteria
I6K52_RS23740	COG3008	intermembrane lipid transfer
I6K52_RS23745	COG2995	paraquat-inducible protein a
I6K52_RS23750	COG1956	GAF domain-containing protein
I6K52_RS23770	COG2814	Major facilitator Superfamily
I6K52_RS23775	COG1414	Transcriptional regulator
I6K52_RS23805	COG0768	penicillin binding
I6K52_RS23810	COG2226	methyltransferase
I6K52_RS23825	COG3716	PTS system mannose fructose sorbose family IID component
I6K52_RS23830	COG3715	PTS system
I6K52_RS23835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K52_RS23835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K52_RS23840	COG1253	flavin adenine dinucleotide binding
I6K52_RS23845	COG2200	EAL domain
I6K52_RS23850	COG1760	l-serine dehydratase
I6K52_RS23870	COG0251	oxidation-reduction process
I6K52_RS23875	COG1199	ATP-dependent helicase activity
I6K52_RS23885	COG3065	identical protein binding
I6K52_RS23895	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K52_RS23905	COG2894	cell division
I6K52_RS23920	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K52_RS23950	COG2719	SpoVR family
I6K52_RS23975	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K52_RS23985	COG4774	siderophore transport
I6K52_RS24000	COG2308	Evidence 4 Homologs of previously reported genes of
I6K52_RS24045	COG0583	DNA-binding transcription factor activity
I6K52_RS24050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K52_RS24065	COG1882	Formate acetyltransferase
I6K52_RS24100	COG0583	DNA-binding transcription factor activity
I6K52_RS24130	COG0583	DNA-binding transcription factor activity
I6K52_RS24145	COG3122	Protein conserved in bacteria
I6K52_RS24165	COG2885	chlorophyll binding
I6K52_RS24225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K52_RS24315	COG0012	GTP binding
I6K52_RS24335	COG0659	secondary active sulfate transmembrane transporter activity
I6K52_RS24365	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K52_RS24385	COG0387	Pfam Sodium calcium exchanger
I6K52_RS24390	COG4572	Cation transport regulator
I6K52_RS24395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K52_RS24405	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K52_RS24410	COG3707	response regulator
I6K52_RS24415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K52_RS24425	COG1116	anion transmembrane transporter activity
I6K52_RS24430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K52_RS24430	COG2146	nitrite reductase [NAD(P)H] activity
I6K52_RS24435	COG0243	molybdopterin cofactor binding
I6K52_RS24440	COG4932	domain protein
I6K52_RS24445	COG2197	response regulator
I6K52_RS24450	COG3850	Histidine kinase
I6K52_RS24455	COG2223	nitrite transmembrane transporter activity
I6K52_RS24465	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K52_RS24470	COG1140	nitrate reductase beta subunit
I6K52_RS24475	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K52_RS24480	COG2181	nitrate reductase activity
I6K52_RS24490	COG1522	sequence-specific DNA binding
I6K52_RS24535	COG0788	formyltetrahydrofolate deformylase activity
I6K52_RS24545	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K52_RS24550	COG0745	RESPONSE REGULATOR receiver
I6K52_RS24555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K52_RS24560	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K52_RS24570	COG1435	thymidine kinase activity
I6K52_RS24575	COG1012	belongs to the aldehyde dehydrogenase family
I6K52_RS24575	COG1454	alcohol dehydrogenase
I6K52_RS24585	COG2095	MarC family integral membrane protein
I6K52_RS24590	COG4166	transmembrane transport
I6K52_RS24595	COG0601	transmembrane transport
I6K52_RS24600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K52_RS24605	COG0444	Belongs to the ABC transporter superfamily
I6K52_RS24615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K52_RS24635	COG2353	YceI-like domain
I6K52_RS24645	COG2350	Protein conserved in bacteria
I6K52_RS24655	COG3001	Fructosamine kinase
I6K52_RS24665	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K52_RS24670	COG3137	Salt-induced outer membrane protein
I6K52_RS24710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K52_RS24710	COG0072	phenylalanine-tRNA ligase activity
I6K52_RS24730	COG0583	DNA-binding transcription factor activity
I6K52_RS24750	COG0386	Belongs to the glutathione peroxidase family
I6K52_RS24760	COG0791	NLP P60 protein
I6K52_RS24770	COG4256	Hemin uptake protein
I6K52_RS24775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K52_RS24790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K52_RS24790	COG0574	Belongs to the PEP-utilizing enzyme family
I6K52_RS24800	COG0628	permease
I6K52_RS24805	COG0277	FAD linked oxidase domain protein
I6K52_RS24805	COG0247	lactate metabolic process
I6K52_RS24810	COG2050	protein possibly involved in aromatic compounds catabolism
I6K52_RS24815	COG2261	transglycosylase associated protein
I6K52_RS24840	COG1120	ATPase activity
I6K52_RS24845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS24855	COG0583	DNA-binding transcription factor activity
I6K52_RS24880	COG1304	FMN binding
I6K52_RS24885	COG1309	transcriptional regulator
I6K52_RS24905	COG0316	Belongs to the HesB IscA family
I6K52_RS24910	COG0719	Fe-S assembly protein
I6K52_RS24915	COG0396	ATPase activity
I6K52_RS24920	COG0719	Fe-S assembly protein
I6K52_RS24935	COG1376	ErfK ybiS ycfS ynhG family protein
I6K52_RS24965	COG1309	transcriptional regulator
I6K52_RS24970	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K52_RS24970	COG1082	Xylose isomerase domain protein TIM barrel
I6K52_RS24975	COG2271	Major facilitator Superfamily
I6K52_RS24980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K52_RS24990	COG1120	ATPase activity
I6K52_RS24995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS25000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K52_RS25005	COG1414	Transcriptional regulator
I6K52_RS25040	COG2814	Major facilitator Superfamily
I6K52_RS25060	COG0583	DNA-binding transcription factor activity
I6K52_RS25065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K52_RS25085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K52_RS25090	COG1116	anion transmembrane transporter activity
I6K52_RS25095	COG4774	siderophore transport
I6K52_RS25100	COG1120	ATPase activity
I6K52_RS25105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS25110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS25130	COG0765	amino acid transport
I6K52_RS25135	COG1126	abc transporter atp-binding protein
I6K52_RS25175	COG3383	formate dehydrogenase (NAD+) activity
I6K52_RS25180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K52_RS25190	COG0765	amino acid transport
I6K52_RS25195	COG0765	amino acid transport
I6K52_RS25200	COG4598	ABC transporter
I6K52_RS25260	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K52_RS25290	COG0739	heme binding
I6K52_RS25300	COG2132	Multicopper oxidase
I6K52_RS25305	COG3667	copper resistance
I6K52_RS25310	COG2372	response to copper ion
I6K52_RS25315	COG1276	copper resistance
I6K52_RS25320	COG0745	RESPONSE REGULATOR receiver
I6K52_RS25325	COG2205	protein histidine kinase activity
I6K52_RS25340	COG3436	PFAM IS66 Orf2 family protein
I6K52_RS25345	COG4372	Transposase
I6K52_RS25380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K52_RS25390	COG1902	pentaerythritol trinitrate reductase activity
I6K52_RS25395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K52_RS25400	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS25405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K52_RS25455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K52_RS25465	COG1902	pentaerythritol trinitrate reductase activity
I6K52_RS25470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K52_RS25475	COG1028	Short-chain dehydrogenase reductase Sdr
I6K52_RS25530	COG1358	cellular component organization or biogenesis
I6K52_RS25600	COG3436	PFAM IS66 Orf2 family protein
I6K52_RS25605	COG4372	Transposase
I6K52_RS25675	COG2814	Major facilitator Superfamily
I6K52_RS25705	COG0583	DNA-binding transcription factor activity
I6K52_RS25710	COG4372	Transposase
I6K52_RS25715	COG3436	PFAM IS66 Orf2 family protein
I6K52_RS25810	COG1595	DNA-templated transcription, initiation
I6K52_RS25815	COG3712	iron ion homeostasis
I6K52_RS25820	COG4772	TonB-dependent receptor
I6K52_RS25825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K52_RS25830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS25835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K52_RS25840	COG1120	ATPase activity
I6K52_RS25845	COG3436	PFAM IS66 Orf2 family protein
I6K52_RS25870	COG0640	Transcriptional regulator
I6K52_RS25875	COG0431	NADPH-dependent FMN reductase
I6K52_RS25905	COG1609	Transcriptional regulator
I6K52_RS25915	COG2223	nitrite transmembrane transporter activity
I6K52_RS26005	COG5642	Protein of unknown function (DUF2384)
I6K52_RS26010	COG5654	RES domain protein
I6K52_RS26040	COG0583	DNA-binding transcription factor activity
I6K52_RS26050	COG3436	PFAM IS66 Orf2 family protein
I6K52_RS26085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K52_RS26090	COG0732	type I restriction modification DNA specificity domain
I6K52_RS26100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6K52_RS26150	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K52_RS26225	COG1271	oxidase subunit
I6K52_RS26230	COG1294	oxidase, subunit
I6K52_RS26240	COG1454	alcohol dehydrogenase
I6K52_RS26270	COG1252	NADH dehydrogenase
I6K52_RS26330	COG3436	PFAM IS66 Orf2 family protein
I6K52_RS26335	COG4372	Transposase
I6K52_RS26345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6K52_RS26355	COG0589	response to stress
I6K52_RS26360	COG0659	secondary active sulfate transmembrane transporter activity
I6K52_RS26370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K52_RS26375	COG1393	Belongs to the ArsC family
I6K52_RS26380	COG0431	NADPH-dependent FMN reductase
I6K52_RS26410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6K52_RS26585	COG3344	reverse transcriptase
I6K52_RS26610	COG2314	TM2 domain