locus-tag	class	description
I6K54_RS00060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K54_RS00085	COG1047	Peptidyl-prolyl cis-trans
I6K54_RS00100	COG0196	riboflavin kinase activity
I6K54_RS00110	COG0583	DNA-binding transcription factor activity
I6K54_RS00135	COG4735	regulation of single-species biofilm formation
I6K54_RS00140	COG1584	GPR1 FUN34 yaaH family protein
I6K54_RS00145	COG0477	Major facilitator Superfamily
I6K54_RS00150	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K54_RS00155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K54_RS00160	COG1115	amino acid carrier protein
I6K54_RS00175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K54_RS00185	COG0460	homoserine dehydrogenase
I6K54_RS00185	COG0527	aspartate kinase activity
I6K54_RS00195	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K54_RS00205	COG0745	RESPONSE REGULATOR receiver
I6K54_RS00215	COG2205	protein histidine kinase activity
I6K54_RS00220	COG0745	RESPONSE REGULATOR receiver
I6K54_RS00225	COG3045	CreA protein
I6K54_RS00230	COG3708	Transcriptional regulator
I6K54_RS00230	COG2207	Transcriptional regulator
I6K54_RS00250	COG0741	lytic transglycosylase activity
I6K54_RS00255	COG0488	(ABC) transporter
I6K54_RS00265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K54_RS00270	COG0560	Phosphoserine phosphatase
I6K54_RS00275	COG3726	membrane protein affecting hemolysin expression
I6K54_RS00305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K54_RS00310	COG0084	hydrolase, TatD family'
I6K54_RS00315	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K54_RS00325	COG2823	Periplasmic or secreted lipoprotein
I6K54_RS00335	COG1011	Hydrolase
I6K54_RS00340	COG0456	acetyltransferase
I6K54_RS00345	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K54_RS00380	COG3706	GGDEF domain
I6K54_RS00385	COG4114	ferric iron reductase
I6K54_RS00390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS00390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS00395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K54_RS00400	COG2197	response regulator
I6K54_RS00405	COG2197	response regulator
I6K54_RS00420	COG2966	Psort location CytoplasmicMembrane, score
I6K54_RS00435	COG1484	DNA-dependent DNA replication
I6K54_RS00450	COG5464	transposase or invertase
I6K54_RS00460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K54_RS00465	COG3716	PTS system mannose fructose sorbose family IID component
I6K54_RS00470	COG3715	PTS system
I6K54_RS00490	COG1214	PFAM Peptidase M22, glycoprotease
I6K54_RS00490	COG0456	acetyltransferase
I6K54_RS00500	COG1737	Transcriptional regulator
I6K54_RS00505	COG0800	Aldolase
I6K54_RS00510	COG3734	2-keto-3-deoxy-galactonokinase
I6K54_RS00525	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K54_RS00555	COG1846	Transcriptional regulator
I6K54_RS00565	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K54_RS00575	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS00580	COG3384	dioxygenase
I6K54_RS00590	COG3971	2-oxopent-4-enoate hydratase activity
I6K54_RS00610	COG2368	4-hydroxyphenylacetate
I6K54_RS00615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K54_RS00630	COG1966	Carbon starvation protein
I6K54_RS00635	COG2879	small protein
I6K54_RS00640	COG0523	cobalamin synthesis protein
I6K54_RS00650	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS00655	COG5464	transposase or invertase
I6K54_RS00660	COG1917	Cupin 2, conserved barrel domain protein
I6K54_RS00660	COG2207	Transcriptional regulator
I6K54_RS00670	COG2733	membrane
I6K54_RS00685	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K54_RS00690	COG1924	4 iron, 4 sulfur cluster binding
I6K54_RS00705	COG1566	PFAM secretion protein HlyD family protein
I6K54_RS00715	COG5457	Domain of unknown function (DUF1127)
I6K54_RS00720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K54_RS00735	COG0583	DNA-binding transcription factor activity
I6K54_RS00740	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K54_RS00750	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS00755	COG1129	ABC transporter
I6K54_RS00760	COG1879	ABC-type sugar transport system periplasmic component
I6K54_RS00770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS00775	COG1129	ABC transporter
I6K54_RS00775	COG0842	Transport permease protein
I6K54_RS00780	COG0842	Transport permease protein
I6K54_RS00810	COG2850	peptidyl-arginine hydroxylation
I6K54_RS00825	COG5002	protein histidine kinase activity
I6K54_RS00830	COG0745	RESPONSE REGULATOR receiver
I6K54_RS00835	COG1538	Outer membrane efflux protein
I6K54_RS00840	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS00850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K54_RS00860	COG3040	lipid binding
I6K54_RS00865	COG0789	Transcriptional regulator
I6K54_RS00870	COG3631	Ketosteroid isomerase-related protein
I6K54_RS00875	COG0300	oxidoreductase activity
I6K54_RS00890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K54_RS00910	COG3272	Protein of unknown function (DUF1722)
I6K54_RS00915	COG4580	involved in the transport of maltose and maltodextrins
I6K54_RS00920	COG2115	Belongs to the xylose isomerase family
I6K54_RS00925	COG2211	Major facilitator Superfamily
I6K54_RS00930	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K54_RS00940	COG0584	glycerophosphoryl diester phosphodiesterase
I6K54_RS00950	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K54_RS01095	COG0582	viral genome integration into host DNA
I6K54_RS01105	COG0288	reversible hydration of carbon dioxide
I6K54_RS01110	COG0659	secondary active sulfate transmembrane transporter activity
I6K54_RS01115	COG1064	alcohol dehydrogenase
I6K54_RS01120	COG1175	transmembrane transport
I6K54_RS01125	COG0395	ABC-type sugar transport system, permease component
I6K54_RS01130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K54_RS01135	COG3842	ATPase activity
I6K54_RS01150	COG1082	Xylose isomerase domain protein TIM barrel
I6K54_RS01160	COG3962	Belongs to the TPP enzyme family
I6K54_RS01165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K54_RS01170	COG0837	glucose binding
I6K54_RS01170	COG1737	Transcriptional regulator
I6K54_RS01175	COG3718	enzyme involved in inositol metabolism
I6K54_RS01190	COG0433	COG0433 Predicted ATPase
I6K54_RS01195	COG0795	lipopolysaccharide-transporting ATPase activity
I6K54_RS01200	COG0795	lipopolysaccharide-transporting ATPase activity
I6K54_RS01210	COG2927	DNA polymerase III (CHI subunit)
I6K54_RS01215	COG0525	valine-tRNA ligase activity
I6K54_RS01240	COG2731	YhcH YjgK YiaL family protein
I6K54_RS01275	COG1263	PTS System
I6K54_RS01275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K54_RS01280	COG0366	Alpha amylase catalytic
I6K54_RS01285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS01290	COG1486	melibiose metabolic process
I6K54_RS01315	COG0602	queuosine metabolic process
I6K54_RS01320	COG2026	Addiction module toxin, RelE StbE family
I6K54_RS01325	COG3077	Addiction module antitoxin, RelB DinJ family
I6K54_RS01330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS01330	COG3711	transcriptional antiterminator
I6K54_RS01335	COG2706	6-phosphogluconolactonase activity
I6K54_RS01350	COG3964	amidohydrolase
I6K54_RS01385	COG0312	modulator of DNA gyrase
I6K54_RS01410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K54_RS01420	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS01425	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS01430	COG1129	ABC transporter
I6K54_RS01435	COG1879	ABC-type sugar transport system periplasmic component
I6K54_RS01455	COG2105	PFAM AIG2 family protein
I6K54_RS01460	COG2911	Protein conserved in bacteria
I6K54_RS01465	COG0729	surface antigen
I6K54_RS01475	COG1253	flavin adenine dinucleotide binding
I6K54_RS01490	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K54_RS01505	COG1733	regulation of RNA biosynthetic process
I6K54_RS01510	COG0702	epimerase
I6K54_RS01520	COG0697	spore germination
I6K54_RS01530	COG1113	amino acid transport
I6K54_RS01535	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K54_RS01540	COG3061	Opacity-associated protein A
I6K54_RS01550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K54_RS01555	COG2965	DNA replication, synthesis of RNA primer
I6K54_RS01615	COG1073	alpha beta
I6K54_RS01620	COG3650	response to hydrogen peroxide
I6K54_RS01630	COG1960	acyl-CoA dehydrogenase activity
I6K54_RS01635	COG0754	glutathionylspermidine amidase activity
I6K54_RS01640	COG5463	Belongs to the UPF0441 family
I6K54_RS01645	COG3766	membrane
I6K54_RS01655	COG1842	Phage shock protein A
I6K54_RS01660	COG3789	protein conserved in bacteria
I6K54_RS01665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K54_RS01670	COG0557	exoribonuclease II activity
I6K54_RS01685	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K54_RS01695	COG0330	HflC and HflK could
I6K54_RS01700	COG0330	HflC and HflK could
I6K54_RS01705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K54_RS01725	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K54_RS01730	COG0802	atpase or kinase
I6K54_RS01735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K54_RS01735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K54_RS01740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K54_RS01760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS01780	COG1511	domain protein
I6K54_RS01780	COG3264	Mechanosensitive ion channel
I6K54_RS01795	COG1053	succinate dehydrogenase
I6K54_RS01800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K54_RS01820	COG2076	Multidrug Resistance protein
I6K54_RS01825	COG5510	response to toxic substance
I6K54_RS01840	COG1509	lysine 2,3-aminomutase activity
I6K54_RS01910	COG0531	amino acid
I6K54_RS01915	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K54_RS01920	COG1027	Aspartate ammonia-lyase
I6K54_RS01925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K54_RS01940	COG1309	transcriptional regulator
I6K54_RS01985	COG0457	Tetratricopeptide repeat
I6K54_RS01990	COG1649	PFAM Uncharacterised BCR, COG1649
I6K54_RS01990	COG0726	polysaccharide deacetylase
I6K54_RS01995	COG1215	transferase activity, transferring glycosyl groups
I6K54_RS02010	COG0861	Integral membrane protein TerC family
I6K54_RS02050	COG1486	melibiose metabolic process
I6K54_RS02055	COG2169	Transcriptional regulator
I6K54_RS02065	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K54_RS02070	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K54_RS02075	COG2188	Transcriptional regulator
I6K54_RS02080	COG3624	Phosphonate C-P lyase system protein PhnG
I6K54_RS02085	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K54_RS02090	COG3626	phosphonate metabolism
I6K54_RS02095	COG3627	carbon phosphorus lyase activity
I6K54_RS02100	COG4107	phosphonate C-P lyase system protein PhnK
I6K54_RS02105	COG4778	phosphonate C-P lyase system protein PhnL
I6K54_RS02110	COG3454	Phosphonate metabolism
I6K54_RS02120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K54_RS02130	COG4191	Histidine kinase
I6K54_RS02130	COG0784	Response regulator, receiver
I6K54_RS02135	COG1129	ABC transporter
I6K54_RS02140	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS02175	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K54_RS02180	COG1301	dicarboxylic acid transport
I6K54_RS02190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K54_RS02195	COG3162	membrane
I6K54_RS02225	COG3539	Fimbrial protein
I6K54_RS02230	COG1346	cytolysis
I6K54_RS02235	COG1380	Effector of murein hydrolase LrgA
I6K54_RS02240	COG0583	DNA-binding transcription factor activity
I6K54_RS02245	COG0025	NhaP-type Na H and K H
I6K54_RS02250	COG2252	PERMEase
I6K54_RS02255	COG0625	glutathione transferase activity
I6K54_RS02260	COG0789	Transcriptional regulator
I6K54_RS02270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K54_RS02300	COG1234	tRNA 3'-trailer cleavage
I6K54_RS02305	COG1609	Transcriptional regulator
I6K54_RS02310	COG0483	inositol monophosphate 1-phosphatase activity
I6K54_RS02325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K54_RS02345	COG4771	TonB-dependent receptor
I6K54_RS02350	COG0741	lytic transglycosylase activity
I6K54_RS02365	COG2315	Protein conserved in bacteria
I6K54_RS02370	COG0432	Pfam Uncharacterised protein family UPF0047
I6K54_RS02385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K54_RS02390	COG0305	Participates in initiation and elongation during chromosome replication
I6K54_RS02405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K54_RS02415	COG0735	belongs to the Fur family
I6K54_RS02420	COG3237	CsbD-like
I6K54_RS02430	COG0534	Mate efflux family protein
I6K54_RS02440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K54_RS02510	COG0251	oxidation-reduction process
I6K54_RS02520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K54_RS02530	COG0527	aspartate kinase activity
I6K54_RS02585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K54_RS02615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K54_RS02625	COG0456	acetyltransferase
I6K54_RS02655	COG0151	Belongs to the GarS family
I6K54_RS02665	COG4191	Histidine kinase
I6K54_RS02705	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K54_RS02720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K54_RS02725	COG2104	thiamine diphosphate biosynthetic process
I6K54_RS02750	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K54_RS02755	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K54_RS02790	COG0250	Participates in transcription elongation, termination and antitermination
I6K54_RS02865	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K54_RS02875	COG1739	Uncharacterized protein family UPF0029
I6K54_RS02915	COG0805	protein transport
I6K54_RS02935	COG3165	ubiquinone biosynthetic process from chorismate
I6K54_RS02965	COG0583	DNA-binding transcription factor activity
I6K54_RS02970	COG0697	spore germination
I6K54_RS02975	COG0561	phosphatase activity
I6K54_RS02980	COG2267	carboxylic ester hydrolase activity
I6K54_RS02985	COG1280	lysine exporter protein (LysE YggA)
I6K54_RS02995	COG1280	lysine exporter protein (LysE YggA)
I6K54_RS03025	COG0210	DNA helicase
I6K54_RS03030	COG1011	Hydrolase
I6K54_RS03060	COG3072	Adenylate cyclase
I6K54_RS03075	COG2959	enzyme of heme biosynthesis
I6K54_RS03080	COG3071	HemY protein
I6K54_RS03125	COG2244	polysaccharide biosynthetic process
I6K54_RS03130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K54_RS03135	COG0456	acetyltransferase
I6K54_RS03140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K54_RS03145	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K54_RS03150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K54_RS03155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K54_RS03165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K54_RS03170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K54_RS03175	COG3118	belongs to the thioredoxin family
I6K54_RS03200	COG1811	Na channel or pump
I6K54_RS03210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K54_RS03215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K54_RS03225	COG0583	DNA-binding transcription factor activity
I6K54_RS03230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K54_RS03245	COG3978	acetolactate synthase activity
I6K54_RS03270	COG3085	chromosome segregation
I6K54_RS03345	COG0583	DNA-binding transcription factor activity
I6K54_RS03360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K54_RS03375	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K54_RS03380	COG2207	Transcriptional regulator
I6K54_RS03390	COG0371	Dehydrogenase
I6K54_RS03405	COG0583	DNA-binding transcription factor activity
I6K54_RS03415	COG0737	Belongs to the 5'-nucleotidase family
I6K54_RS03425	COG0527	aspartate kinase activity
I6K54_RS03425	COG0460	homoserine dehydrogenase
I6K54_RS03430	COG0626	cystathionine gamma-synthase activity
I6K54_RS03445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K54_RS03450	COG1609	Transcriptional regulator
I6K54_RS03455	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K54_RS03470	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K54_RS03490	COG3678	ATP-independent chaperone mediated protein folding
I6K54_RS03495	COG0745	RESPONSE REGULATOR receiver
I6K54_RS03500	COG2205	protein histidine kinase activity
I6K54_RS03505	COG2258	MOSC domain
I6K54_RS03510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K54_RS03550	COG1129	ABC transporter
I6K54_RS03555	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS03560	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS03565	COG1454	alcohol dehydrogenase
I6K54_RS03575	COG2211	Major facilitator Superfamily
I6K54_RS03635	COG0205	6-phosphofructokinase activity
I6K54_RS03655	COG0437	4 iron, 4 sulfur cluster binding
I6K54_RS03660	COG2864	formate dehydrogenase
I6K54_RS03675	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K54_RS03685	COG0456	acetyltransferase
I6K54_RS03700	COG1011	Hydrolase
I6K54_RS03715	COG3852	Histidine kinase
I6K54_RS03730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K54_RS03750	COG0204	Acyl-transferase
I6K54_RS03760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K54_RS03765	COG3084	Protein conserved in bacteria
I6K54_RS03775	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K54_RS03800	COG2186	Transcriptional regulator
I6K54_RS03805	COG0477	Major facilitator Superfamily
I6K54_RS03810	COG1609	Transcriptional regulator
I6K54_RS03815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K54_RS03825	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS03830	COG1129	ABC transporter
I6K54_RS03860	COG1522	sequence-specific DNA binding
I6K54_RS03865	COG0716	FMN binding
I6K54_RS03880	COG3312	ion transport
I6K54_RS03930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K54_RS03935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K54_RS03940	COG0573	inorganic phosphate transmembrane transporter activity
I6K54_RS03945	COG0581	inorganic phosphate transmembrane transporter activity
I6K54_RS03950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K54_RS03955	COG0704	Plays a role in the regulation of phosphate uptake
I6K54_RS03965	COG2382	esterase
I6K54_RS03970	COG0363	glucosamine-6-phosphate deaminase activity
I6K54_RS03975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K54_RS03980	COG2252	PERMEase
I6K54_RS03985	COG0431	NADPH-dependent FMN reductase
I6K54_RS03990	COG2091	lysine biosynthetic process via aminoadipic acid
I6K54_RS04020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K54_RS04050	COG0187	DNA topoisomerase II activity
I6K54_RS04055	COG0561	phosphatase activity
I6K54_RS04070	COG2186	Transcriptional regulator
I6K54_RS04075	COG3734	2-keto-3-deoxy-galactonokinase
I6K54_RS04080	COG0800	Aldolase
I6K54_RS04090	COG2271	Major facilitator Superfamily
I6K54_RS04095	COG0823	Involved in the tonB-independent uptake of proteins
I6K54_RS04100	COG5645	(Lipo)protein
I6K54_RS04115	COG3645	SOS response
I6K54_RS04125	COG2188	Transcriptional regulator
I6K54_RS04140	COG2149	membrane
I6K54_RS04160	COG2610	gluconate transmembrane transporter activity
I6K54_RS04170	COG0583	DNA-binding transcription factor activity
I6K54_RS04175	COG2814	Major facilitator Superfamily
I6K54_RS04205	COG0028	Belongs to the TPP enzyme family
I6K54_RS04210	COG0440	acetolactate synthase activity
I6K54_RS04215	COG2197	response regulator
I6K54_RS04225	COG2271	Major facilitator Superfamily
I6K54_RS04265	COG2188	Transcriptional regulator
I6K54_RS04290	COG4580	involved in the transport of maltose and maltodextrins
I6K54_RS04295	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K54_RS04300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS04300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS04310	COG1609	Transcriptional regulator
I6K54_RS04320	COG3384	dioxygenase
I6K54_RS04325	COG0583	DNA-binding transcription factor activity
I6K54_RS04330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K54_RS04335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K54_RS04340	COG2828	Protein conserved in bacteria
I6K54_RS04355	COG0697	spore germination
I6K54_RS04360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K54_RS04360	COG1263	PTS System
I6K54_RS04370	COG2814	Major facilitator Superfamily
I6K54_RS04380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K54_RS04415	COG0583	DNA-binding transcription factor activity
I6K54_RS04440	COG1464	Belongs to the NlpA lipoprotein family
I6K54_RS04455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K54_RS04465	COG1064	alcohol dehydrogenase
I6K54_RS04495	COG2211	Major facilitator Superfamily
I6K54_RS04500	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K54_RS04510	COG1486	melibiose metabolic process
I6K54_RS04515	COG1263	PTS System
I6K54_RS04515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K54_RS04520	COG2982	Protein involved in outer membrane biogenesis
I6K54_RS04525	COG2233	PERMEase
I6K54_RS04530	COG0786	glutamate:sodium symporter activity
I6K54_RS04550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K54_RS04575	COG3152	Membrane
I6K54_RS04585	COG1494	fructose-1,6-bisphosphatase
I6K54_RS04590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K54_RS04595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K54_RS04600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K54_RS04620	COG2860	membrane
I6K54_RS04630	COG2169	Transcriptional regulator
I6K54_RS04630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K54_RS04655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K54_RS04690	COG1561	YicC-like family, N-terminal region
I6K54_RS04715	COG0842	Transport permease protein
I6K54_RS04740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K54_RS04760	COG4245	von Willebrand factor, type A
I6K54_RS04795	COG1519	Transferase
I6K54_RS04800	COG1216	Glycosyl transferase, family 2
I6K54_RS04805	COG0438	transferase activity, transferring glycosyl groups
I6K54_RS04815	COG0859	PFAM glycosyl transferase family 9
I6K54_RS04840	COG0859	PFAM glycosyl transferase family 9
I6K54_RS04855	COG0156	8-amino-7-oxononanoate synthase activity
I6K54_RS04865	COG0463	Glycosyl transferase, family 2
I6K54_RS04870	COG2861	carbohydrate metabolic process
I6K54_RS04875	COG4942	peptidase
I6K54_RS04885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K54_RS04890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K54_RS04910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K54_RS04920	COG2186	Transcriptional regulator
I6K54_RS04940	COG3722	fumarate hydratase activity
I6K54_RS04960	COG1566	PFAM secretion protein HlyD family protein
I6K54_RS04965	COG0625	glutathione transferase activity
I6K54_RS04975	COG3276	selenocysteine insertion sequence binding
I6K54_RS04980	COG1414	Transcriptional regulator
I6K54_RS04985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K54_RS04990	COG3977	Valine--pyruvate aminotransferase
I6K54_RS04995	COG0366	Alpha amylase catalytic
I6K54_RS05000	COG2992	FlgJ-related protein
I6K54_RS05005	COG1609	Transcriptional regulator
I6K54_RS05005	COG2207	Transcriptional regulator
I6K54_RS05010	COG4214	carbohydrate transport
I6K54_RS05020	COG4213	ABC transporter substrate-binding protein
I6K54_RS05035	COG4682	membrane
I6K54_RS05040	COG4682	membrane
I6K54_RS05045	COG3274	enterobacterial common antigen metabolic process
I6K54_RS05080	COG1278	Cold shock
I6K54_RS05085	COG2944	sequence-specific DNA binding
I6K54_RS05090	COG2814	Major facilitator Superfamily
I6K54_RS05110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K54_RS05120	COG1609	Transcriptional regulator
I6K54_RS05125	COG2885	chlorophyll binding
I6K54_RS05130	COG0243	molybdopterin cofactor binding
I6K54_RS05135	COG0456	acetyltransferase
I6K54_RS05140	COG2818	Glycosylase
I6K54_RS05145	COG5571	outer membrane autotransporter
I6K54_RS05150	COG2223	nitrite transmembrane transporter activity
I6K54_RS05180	COG0747	negative chemotaxis
I6K54_RS05185	COG0601	transmembrane transport
I6K54_RS05190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K54_RS05195	COG0444	Belongs to the ABC transporter superfamily
I6K54_RS05200	COG4608	Belongs to the ABC transporter superfamily
I6K54_RS05215	COG2894	cell division
I6K54_RS05225	COG1215	transferase activity, transferring glycosyl groups
I6K54_RS05230	COG0457	Tetratricopeptide repeat
I6K54_RS05245	COG2194	sulfuric ester hydrolase activity
I6K54_RS05275	COG1215	transferase activity, transferring glycosyl groups
I6K54_RS05280	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K54_RS05285	COG3118	belongs to the thioredoxin family
I6K54_RS05285	COG0457	Tetratricopeptide repeat
I6K54_RS05290	COG2200	EAL domain
I6K54_RS05290	COG2199	diguanylate cyclase activity
I6K54_RS05300	COG0612	Peptidase, M16
I6K54_RS05310	COG2982	Protein involved in outer membrane biogenesis
I6K54_RS05315	COG0477	Major facilitator Superfamily
I6K54_RS05320	COG1295	ribonuclease BN
I6K54_RS05325	COG0583	DNA-binding transcription factor activity
I6K54_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS05335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K54_RS05345	COG1454	alcohol dehydrogenase
I6K54_RS05355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K54_RS05360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K54_RS05365	COG0671	phosphoesterase, PA-phosphatase related
I6K54_RS05385	COG0589	response to stress
I6K54_RS05395	COG0306	phosphate transporter
I6K54_RS05400	COG2081	HI0933 family
I6K54_RS05405	COG2239	Acts as a magnesium transporter
I6K54_RS05415	COG1124	(ABC) transporter
I6K54_RS05425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K54_RS05430	COG0601	transmembrane transport
I6K54_RS05435	COG0747	negative chemotaxis
I6K54_RS05445	COG3479	Phenolic acid decarboxylase
I6K54_RS05485	COG0628	permease
I6K54_RS05490	COG0477	Major facilitator Superfamily
I6K54_RS05500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K54_RS05515	COG3714	YhhN family
I6K54_RS05525	COG3776	membrane
I6K54_RS05530	COG0742	ribosomal rna small subunit methyltransferase
I6K54_RS05535	COG0552	protein localization to endoplasmic reticulum
I6K54_RS05540	COG2884	Cell division ATP-binding protein ftsE
I6K54_RS05545	COG2177	Part of the ABC transporter FtsEX involved in
I6K54_RS05560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K54_RS05570	COG0683	leucine binding
I6K54_RS05580	COG0683	leucine binding
I6K54_RS05585	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS05635	COG0584	glycerophosphoryl diester phosphodiesterase
I6K54_RS05645	COG0405	Gamma-glutamyltransferase
I6K54_RS05650	COG1247	-acetyltransferase
I6K54_RS05660	COG0673	inositol 2-dehydrogenase activity
I6K54_RS05665	COG1741	Belongs to the pirin family
I6K54_RS05670	COG1609	Transcriptional regulator
I6K54_RS05675	COG3265	gluconokinase activity
I6K54_RS05680	COG2610	gluconate transmembrane transporter activity
I6K54_RS05690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K54_RS05715	COG0058	SHG alpha-glucan phosphorylase activity
I6K54_RS05720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K54_RS05735	COG1349	DNA-binding transcription factor activity
I6K54_RS05745	COG0058	SHG alpha-glucan phosphorylase activity
I6K54_RS05750	COG1640	4-alpha-glucanotransferase
I6K54_RS05755	COG2610	gluconate transmembrane transporter activity
I6K54_RS05765	COG1040	competence protein
I6K54_RS05790	COG1918	ferrous iron import across plasma membrane
I6K54_RS05795	COG2183	response to ionizing radiation
I6K54_RS05800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K54_RS05825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K54_RS05830	COG1011	Hydrolase
I6K54_RS05840	COG0494	nUDIX hydrolase
I6K54_RS05845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K54_RS05870	COG4796	Type ii and iii secretion system protein
I6K54_RS05885	COG3266	domain, Protein
I6K54_RS05890	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K54_RS05895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K54_RS05920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K54_RS05925	COG0402	S-adenosylhomocysteine deaminase activity
I6K54_RS05930	COG0738	Major facilitator superfamily
I6K54_RS05955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K54_RS05960	COG1289	transmembrane transporter activity
I6K54_RS05970	COG1765	OsmC-like protein
I6K54_RS05975	COG3954	Phosphoribulokinase
I6K54_RS05985	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K54_RS05990	COG0488	(ABC) transporter
I6K54_RS06005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K54_RS06010	COG1047	Peptidyl-prolyl cis-trans
I6K54_RS06020	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K54_RS06025	COG2964	Protein conserved in bacteria
I6K54_RS06080	COG0051	transcription antitermination factor activity, RNA binding
I6K54_RS06105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K54_RS06120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K54_RS06185	COG0201	protein transport
I6K54_RS06210	COG0202	RNA polymerase activity
I6K54_RS06225	COG0789	Transcriptional regulator
I6K54_RS06230	COG3036	rescue of stalled ribosome
I6K54_RS06260	COG0758	DNA mediated transformation
I6K54_RS06270	COG0551	DNA topoisomerase type I activity
I6K54_RS06290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K54_RS06325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K54_RS06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS06335	COG1309	transcriptional regulator
I6K54_RS06355	COG4145	pantothenate transmembrane transporter activity
I6K54_RS06360	COG3924	membrane
I6K54_RS06365	COG0439	Biotin carboxylase
I6K54_RS06370	COG0511	ligase activity, forming carbon-carbon bonds
I6K54_RS06395	COG2199	diguanylate cyclase activity
I6K54_RS06395	COG2200	EAL domain
I6K54_RS06400	COG1077	Cell shape determining protein MreB Mrl
I6K54_RS06405	COG1792	Involved in formation and maintenance of cell shape
I6K54_RS06410	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K54_RS06420	COG1530	ribonuclease E activity
I6K54_RS06425	COG3164	Protein of unknown function
I6K54_RS06430	COG0312	modulator of DNA gyrase
I6K54_RS06435	COG0583	DNA-binding transcription factor activity
I6K54_RS06450	COG1289	transmembrane transporter activity
I6K54_RS06455	COG2732	(Barnase) inhibitor
I6K54_RS06480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K54_RS06485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K54_RS06490	COG3105	Protein conserved in bacteria
I6K54_RS06495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K54_RS06515	COG0625	glutathione transferase activity
I6K54_RS06520	COG2969	positive regulation of protein catabolic process
I6K54_RS06530	COG0493	'glutamate synthase
I6K54_RS06535	COG0070	glutamate synthase
I6K54_RS06535	COG0067	glutamate synthase
I6K54_RS06535	COG0069	glutamate synthase activity
I6K54_RS06540	COG1242	4 iron, 4 sulfur cluster binding
I6K54_RS06545	COG2271	Major facilitator Superfamily
I6K54_RS06550	COG1063	alcohol dehydrogenase
I6K54_RS06555	COG1312	Catalyzes the dehydration of D-mannonate
I6K54_RS06560	COG5002	protein histidine kinase activity
I6K54_RS06560	COG2198	Histidine kinase
I6K54_RS06560	COG0784	Response regulator, receiver
I6K54_RS06565	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K54_RS06570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K54_RS06575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS06585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS06590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K54_RS06595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K54_RS06600	COG1137	ATPase activity
I6K54_RS06605	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K54_RS06610	COG3117	lipopolysaccharide transmembrane transporter activity
I6K54_RS06615	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K54_RS06625	COG0530	calcium, potassium:sodium antiporter activity
I6K54_RS06630	COG1127	ABC transporter
I6K54_RS06635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K54_RS06640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K54_RS06645	COG2854	intermembrane phospholipid transfer
I6K54_RS06650	COG3113	response to antibiotic
I6K54_RS06655	COG5007	Belongs to the BolA IbaG family
I6K54_RS06665	COG3423	Transcriptional regulator
I6K54_RS06670	COG0142	geranyltranstransferase activity
I6K54_RS06685	COG0697	spore germination
I6K54_RS06695	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K54_RS06705	COG1534	Rna-binding protein
I6K54_RS06715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K54_RS06720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K54_RS06730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K54_RS06770	COG0195	Participates in both transcription termination and antitermination
I6K54_RS06815	COG0814	amino acid
I6K54_RS06840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6K54_RS06885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K54_RS06890	COG0826	peptidase U32
I6K54_RS06895	COG0826	peptidase U32
I6K54_RS06900	COG3154	lipid carrier protein
I6K54_RS06905	COG3153	acetyltransferase
I6K54_RS06920	COG0693	protein deglycase activity
I6K54_RS06925	COG0702	epimerase
I6K54_RS06930	COG0701	Predicted permease
I6K54_RS06935	COG2823	Periplasmic or secreted lipoprotein
I6K54_RS06955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K54_RS06970	COG1063	alcohol dehydrogenase
I6K54_RS06975	COG3775	system Galactitol-specific IIC component
I6K54_RS06980	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K54_RS06985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS06995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS06995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS07000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K54_RS07000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K54_RS07000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS07005	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K54_RS07015	COG1349	DNA-binding transcription factor activity
I6K54_RS07020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K54_RS07025	COG2721	sulfolactate sulfo-lyase activity
I6K54_RS07030	COG2271	Major facilitator Superfamily
I6K54_RS07040	COG2084	Dehydrogenase
I6K54_RS07045	COG1929	Belongs to the glycerate kinase type-1 family
I6K54_RS07070	COG1741	Belongs to the pirin family
I6K54_RS07075	COG0583	DNA-binding transcription factor activity
I6K54_RS07080	COG3152	Membrane
I6K54_RS07085	COG0435	Glutathione S-transferase
I6K54_RS07090	COG2259	Doxx family
I6K54_RS07100	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K54_RS07105	COG4575	ribosome binding
I6K54_RS07110	COG1422	Protein of unknown function (DUF1090)
I6K54_RS07120	COG0586	Pfam SNARE associated Golgi protein
I6K54_RS07125	COG2186	Transcriptional regulator
I6K54_RS07130	COG2271	Major facilitator Superfamily
I6K54_RS07140	COG2721	sulfolactate sulfo-lyase activity
I6K54_RS07155	COG0861	Integral membrane protein TerC family
I6K54_RS07160	COG0673	inositol 2-dehydrogenase activity
I6K54_RS07165	COG1451	nucleotide metabolic process
I6K54_RS07185	COG1902	pentaerythritol trinitrate reductase activity
I6K54_RS07185	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K54_RS07235	COG1695	Transcriptional regulator
I6K54_RS07240	COG2375	cellular response to nickel ion
I6K54_RS07255	COG1461	Dihydroxyacetone kinase
I6K54_RS07260	COG2376	Dihydroxyacetone kinase
I6K54_RS07330	COG3247	response to pH
I6K54_RS07340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS07340	COG2198	Histidine kinase
I6K54_RS07340	COG0784	Response regulator, receiver
I6K54_RS07340	COG2205	protein histidine kinase activity
I6K54_RS07345	COG2197	response regulator
I6K54_RS07370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K54_RS07375	COG0358	DNA primase activity
I6K54_RS07380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K54_RS07445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K54_RS07460	COG4991	sh3 domain protein
I6K54_RS07465	COG3025	triphosphatase activity
I6K54_RS07490	COG2960	long-chain fatty acid transporting porin activity
I6K54_RS07505	COG3384	dioxygenase
I6K54_RS07510	COG0754	glutathionylspermidine amidase activity
I6K54_RS07525	COG0494	nUDIX hydrolase
I6K54_RS07530	COG3151	Protein conserved in bacteria
I6K54_RS07535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K54_RS07540	COG3150	esterase
I6K54_RS07550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K54_RS07555	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K54_RS07560	COG0642	Histidine kinase
I6K54_RS07570	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K54_RS07575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K54_RS07580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K54_RS07585	COG0204	Acyl-transferase
I6K54_RS07590	COG2132	Multicopper oxidase
I6K54_RS07595	COG1032	radical SAM domain protein
I6K54_RS07605	COG0656	L-ascorbic acid biosynthetic process
I6K54_RS07610	COG1979	alcohol dehydrogenase
I6K54_RS07615	COG2207	Transcriptional regulator
I6K54_RS07620	COG0586	Pfam SNARE associated Golgi protein
I6K54_RS07625	COG0626	cystathionine gamma-synthase activity
I6K54_RS07635	COG0848	biopolymer transport protein
I6K54_RS07640	COG2211	Major facilitator Superfamily
I6K54_RS07665	COG0625	glutathione transferase activity
I6K54_RS07680	COG0754	glutathionylspermidine amidase activity
I6K54_RS07685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K54_RS07705	COG0583	DNA-binding transcription factor activity
I6K54_RS07710	COG0626	cystathionine gamma-synthase activity
I6K54_RS07745	COG1811	Na channel or pump
I6K54_RS07750	COG1982	Orn Lys Arg decarboxylase major
I6K54_RS07755	COG2211	Major facilitator Superfamily
I6K54_RS07770	COG1194	a g-specific adenine glycosylase
I6K54_RS07780	COG3171	Protein conserved in bacteria
I6K54_RS07790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K54_RS07805	COG0762	integral membrane protein
I6K54_RS07810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K54_RS07815	COG2805	Type II/IV secretion system protein
I6K54_RS07835	COG0189	ligase activity
I6K54_RS07840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K54_RS07845	COG2356	endonuclease I
I6K54_RS07855	COG2814	Major facilitator Superfamily
I6K54_RS07890	COG2146	nitrite reductase [NAD(P)H] activity
I6K54_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS07910	COG1414	Transcriptional regulator
I6K54_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS07945	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K54_RS07965	COG0501	Belongs to the peptidase M48B family
I6K54_RS07970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K54_RS07985	COG0191	fructose-bisphosphate aldolase activity
I6K54_RS07990	COG0668	transmembrane transport
I6K54_RS08000	COG2968	Membrane
I6K54_RS08015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K54_RS08020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K54_RS08040	COG0006	proline dipeptidase activity
I6K54_RS08045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K54_RS08050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K54_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS08075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K54_RS08095	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS08100	COG1737	Transcriptional regulator
I6K54_RS08110	COG1272	protein, Hemolysin III
I6K54_RS08120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K54_RS08130	COG0716	FMN binding
I6K54_RS08135	COG4974	Belongs to the 'phage' integrase family
I6K54_RS08145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K54_RS08165	COG4942	peptidase
I6K54_RS08250	COG2814	Major facilitator Superfamily
I6K54_RS08280	COG0667	Aldo Keto reductase
I6K54_RS08320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K54_RS08325	COG1393	Belongs to the ArsC family
I6K54_RS08340	COG1538	Outer membrane efflux protein
I6K54_RS08345	COG1289	transmembrane transporter activity
I6K54_RS08360	COG3592	Divergent 4Fe-4S mono-cluster
I6K54_RS08365	COG2388	GCN5-related N-acetyl-transferase
I6K54_RS08375	COG3539	Fimbrial protein
I6K54_RS08380	COG3539	Fimbrial protein
I6K54_RS08385	COG3539	Fimbrial protein
I6K54_RS08390	COG3188	usher protein
I6K54_RS08395	COG3121	Chaperone
I6K54_RS08400	COG3539	Fimbrial protein
I6K54_RS08410	COG4974	Belongs to the 'phage' integrase family
I6K54_RS08415	COG0582	viral genome integration into host DNA
I6K54_RS08420	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K54_RS08425	COG1846	Transcriptional regulator
I6K54_RS08430	COG0697	spore germination
I6K54_RS08480	COG0667	Aldo Keto reductase
I6K54_RS08485	COG0814	amino acid
I6K54_RS08500	COG0183	Belongs to the thiolase family
I6K54_RS08510	COG0823	Involved in the tonB-independent uptake of proteins
I6K54_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS08520	COG2814	Major facilitator Superfamily
I6K54_RS08555	COG3842	ATPase activity
I6K54_RS08560	COG0395	ABC-type sugar transport system, permease component
I6K54_RS08565	COG1175	transmembrane transport
I6K54_RS08570	COG1917	Cupin 2, conserved barrel domain protein
I6K54_RS08575	COG1794	racemase activity, acting on amino acids and derivatives
I6K54_RS08580	COG0583	DNA-binding transcription factor activity
I6K54_RS08590	COG1609	Transcriptional regulator
I6K54_RS08595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS08600	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS08605	COG2186	Transcriptional regulator
I6K54_RS08615	COG1609	Transcriptional regulator
I6K54_RS08635	COG0667	Aldo Keto reductase
I6K54_RS08645	COG0861	Integral membrane protein TerC family
I6K54_RS08680	COG2165	general secretion pathway protein
I6K54_RS08685	COG4795	General secretion pathway protein
I6K54_RS08695	COG4967	type IV pilus modification protein PilV
I6K54_RS08700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K54_RS08705	COG1025	Belongs to the peptidase M16 family
I6K54_RS08710	COG1074	ATP-dependent DNA helicase activity
I6K54_RS08715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K54_RS08725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K54_RS08725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K54_RS08730	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K54_RS08735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K54_RS08765	COG4656	Part of a membrane complex involved in electron transport
I6K54_RS08770	COG1454	alcohol dehydrogenase
I6K54_RS08770	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS08800	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K54_RS08965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K54_RS08970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K54_RS08975	COG2166	iron-sulfur cluster assembly
I6K54_RS08980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K54_RS08990	COG0583	DNA-binding transcription factor activity
I6K54_RS08995	COG2363	Small membrane protein
I6K54_RS09005	COG1349	DNA-binding transcription factor activity
I6K54_RS09025	COG0738	Major facilitator superfamily
I6K54_RS09030	COG0235	Class ii aldolase
I6K54_RS09055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K54_RS09070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K54_RS09075	COG2011	ABC-type metal ion transport system permease component
I6K54_RS09080	COG1464	Belongs to the NlpA lipoprotein family
I6K54_RS09085	COG0477	Major facilitator Superfamily
I6K54_RS09095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K54_RS09100	COG1760	l-serine dehydratase
I6K54_RS09105	COG0814	amino acid
I6K54_RS09110	COG1611	Belongs to the LOG family
I6K54_RS09125	COG3098	single-species biofilm formation
I6K54_RS09130	COG0564	pseudouridine synthase activity
I6K54_RS09135	COG0716	FMN binding
I6K54_RS09140	COG2271	Major facilitator Superfamily
I6K54_RS09145	COG4948	Mandelate Racemase Muconate Lactonizing
I6K54_RS09150	COG4948	Mandelate Racemase Muconate Lactonizing
I6K54_RS09155	COG1929	Belongs to the glycerate kinase type-1 family
I6K54_RS09160	COG4999	Histidine kinase
I6K54_RS09160	COG2205	protein histidine kinase activity
I6K54_RS09160	COG3850	Histidine kinase
I6K54_RS09160	COG3437	response regulator, receiver
I6K54_RS09170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K54_RS09175	COG3956	TIGRFAM MazG family protein
I6K54_RS09195	COG0602	queuosine metabolic process
I6K54_RS09200	COG0720	synthase
I6K54_RS09240	COG2234	aminopeptidase activity
I6K54_RS09300	COG4942	peptidase
I6K54_RS09300	COG1388	LysM domain
I6K54_RS09305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K54_RS09330	COG0163	prenyltransferase activity
I6K54_RS09335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K54_RS09375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS09380	COG4558	Periplasmic binding protein
I6K54_RS09385	COG3720	iron ion transport
I6K54_RS09405	COG0679	Auxin Efflux Carrier
I6K54_RS09420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K54_RS09425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K54_RS09430	COG1121	(ABC) transporter
I6K54_RS09440	COG1609	Transcriptional regulator
I6K54_RS09445	COG1940	carbohydrate kinase activity
I6K54_RS09450	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K54_RS09455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS09460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS09465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS09470	COG4580	involved in the transport of maltose and maltodextrins
I6K54_RS09480	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS09490	COG0309	Hydrogenase expression formation protein (HypE)
I6K54_RS09495	COG0409	Hydrogenase expression formation protein
I6K54_RS09500	COG0298	carbon dioxide binding
I6K54_RS09505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K54_RS09520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K54_RS09525	COG0651	ATP synthesis coupled electron transport
I6K54_RS09530	COG0650	Formate hydrogenlyase subunit 4
I6K54_RS09535	COG3261	NADH dehydrogenase
I6K54_RS09535	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K54_RS09540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K54_RS09545	COG3260	NADH ubiquinone oxidoreductase 20
I6K54_RS09555	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K54_RS09565	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS09570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K54_RS09570	COG1263	PTS System
I6K54_RS09575	COG1609	Transcriptional regulator
I6K54_RS09580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K54_RS09585	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K54_RS09590	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K54_RS09615	COG1349	DNA-binding transcription factor activity
I6K54_RS09620	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS09625	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS09635	COG3732	PTS system glucitol sorbitol-specific
I6K54_RS09640	COG3730	PTS system glucitol sorbitol-specific
I6K54_RS09645	COG2951	lytic endotransglycosylase activity
I6K54_RS09650	COG1121	(ABC) transporter
I6K54_RS09655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K54_RS09660	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K54_RS09665	COG1546	Belongs to the CinA family
I6K54_RS09685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K54_RS09715	COG2823	Periplasmic or secreted lipoprotein
I6K54_RS09720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K54_RS09725	COG1238	metal cluster binding
I6K54_RS09745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K54_RS09750	COG2814	Major facilitator Superfamily
I6K54_RS09755	COG1566	PFAM secretion protein HlyD family protein
I6K54_RS09760	COG1846	Transcriptional regulator
I6K54_RS09770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K54_RS09780	COG4176	ABC-type proline glycine betaine transport system permease component
I6K54_RS09795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K54_RS09805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K54_RS09810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K54_RS09815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K54_RS09820	COG4575	ribosome binding
I6K54_RS09835	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K54_RS09850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K54_RS09855	COG0640	Transcriptional regulator
I6K54_RS09865	COG0583	DNA-binding transcription factor activity
I6K54_RS09870	COG3284	Transcriptional regulator
I6K54_RS09880	COG3539	Fimbrial protein
I6K54_RS09885	COG3121	Chaperone
I6K54_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS09930	COG0235	Class ii aldolase
I6K54_RS09940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS09990	COG2207	Transcriptional regulator
I6K54_RS09990	COG3708	Transcriptional regulator
I6K54_RS10020	COG1204	response to ionizing radiation
I6K54_RS10045	COG0515	serine threonine protein kinase
I6K54_RS10045	COG2815	serine threonine protein kinase
I6K54_RS10050	COG0582	viral genome integration into host DNA
I6K54_RS10065	COG2867	negative regulation of translational initiation
I6K54_RS10080	COG0497	DNA recombination
I6K54_RS10095	COG4536	flavin adenine dinucleotide binding
I6K54_RS10100	COG4137	Cytochrome C assembly protein
I6K54_RS10105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K54_RS10140	COG2885	chlorophyll binding
I6K54_RS10145	COG2199	diguanylate cyclase activity
I6K54_RS10155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K54_RS10160	COG1605	Chorismate mutase
I6K54_RS10160	COG0287	Prephenate dehydrogenase
I6K54_RS10170	COG0077	Prephenate dehydratase
I6K54_RS10170	COG1605	Chorismate mutase
I6K54_RS10180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K54_RS10185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K54_RS10200	COG0542	response to heat
I6K54_RS10225	COG0477	Major facilitator Superfamily
I6K54_RS10230	COG5544	Lipoprotein
I6K54_RS10235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K54_RS10245	COG3148	PFAM DTW domain containing protein
I6K54_RS10250	COG3118	belongs to the thioredoxin family
I6K54_RS10255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K54_RS10270	COG0513	Belongs to the DEAD box helicase family
I6K54_RS10280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K54_RS10295	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K54_RS10300	COG3026	antisigma factor binding
I6K54_RS10305	COG3086	response to oxidative stress
I6K54_RS10315	COG0681	Belongs to the peptidase S26 family
I6K54_RS10335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K54_RS10345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K54_RS10350	COG1737	Transcriptional regulator
I6K54_RS10355	COG0560	Phosphoserine phosphatase
I6K54_RS10370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K54_RS10370	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K54_RS10375	COG2205	protein histidine kinase activity
I6K54_RS10380	COG3170	Tfp pilus assembly protein FimV
I6K54_RS10385	COG2204	response regulator
I6K54_RS10390	COG0347	Belongs to the P(II) protein family
I6K54_RS10395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K54_RS10395	COG1017	nitric oxide dioxygenase activity
I6K54_RS10405	COG2259	Doxx family
I6K54_RS10410	COG1940	carbohydrate kinase activity
I6K54_RS10415	COG0457	Tetratricopeptide repeat
I6K54_RS10420	COG2814	Major facilitator Superfamily
I6K54_RS10420	COG0477	Major facilitator Superfamily
I6K54_RS10425	COG2017	converts alpha-aldose to the beta-anomer
I6K54_RS10430	COG2814	Major facilitator Superfamily
I6K54_RS10435	COG3711	transcriptional antiterminator
I6K54_RS10440	COG3683	transport system, periplasmic component
I6K54_RS10445	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K54_RS10475	COG0822	iron-sulfur transferase activity
I6K54_RS10495	COG0633	Ferredoxin
I6K54_RS10500	COG2975	iron-sulfur cluster assembly
I6K54_RS10520	COG2897	thiosulfate sulfurtransferase activity
I6K54_RS10525	COG2373	Large extracellular alpha-helical protein
I6K54_RS10530	COG4953	penicillin-binding protein 1C
I6K54_RS10545	COG3039	Transposase
I6K54_RS10565	COG2976	Protein conserved in bacteria
I6K54_RS10585	COG1645	bacterial-type flagellum-dependent swarming motility
I6K54_RS10595	COG0517	IMP dehydrogenase activity
I6K54_RS10595	COG0516	GMP reductase activity
I6K54_RS10605	COG3119	arylsulfatase activity
I6K54_RS10610	COG0641	radical SAM
I6K54_RS10630	COG2200	EAL domain
I6K54_RS10645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K54_RS10660	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS10670	COG2233	PERMEase
I6K54_RS10685	COG1393	Belongs to the ArsC family
I6K54_RS10690	COG4783	chaperone-mediated protein folding
I6K54_RS10700	COG0628	permease
I6K54_RS10705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K54_RS10710	COG2716	regulation of RNA biosynthetic process
I6K54_RS10720	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K54_RS10730	COG2321	neutral zinc metallopeptidase
I6K54_RS10735	COG1444	tRNA N-acetyltransferase activity
I6K54_RS10740	COG0400	carboxylic ester hydrolase activity
I6K54_RS10755	COG1393	Belongs to the ArsC family
I6K54_RS10765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K54_RS10770	COG0493	'glutamate synthase
I6K54_RS10770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K54_RS10780	COG5342	invasion associated locus B
I6K54_RS10785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K54_RS10790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K54_RS10800	COG4810	utilization protein
I6K54_RS10890	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K54_RS10910	COG2837	iron assimilation
I6K54_RS10920	COG4150	thiosulfate binding
I6K54_RS10925	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K54_RS10930	COG4208	sulfate ABC transporter
I6K54_RS10935	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K54_RS10945	COG4319	ketosteroid isomerase
I6K54_RS10980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K54_RS11000	COG3530	Putative quorum-sensing-regulated virulence factor
I6K54_RS11005	COG0385	Bile acid
I6K54_RS11010	COG0583	DNA-binding transcription factor activity
I6K54_RS11045	COG3415	Transposase
I6K54_RS11050	COG3415	Transposase
I6K54_RS11065	COG2199	diguanylate cyclase activity
I6K54_RS11065	COG2200	EAL domain
I6K54_RS11070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K54_RS11085	COG0667	Aldo Keto reductase
I6K54_RS11090	COG3961	Belongs to the TPP enzyme family
I6K54_RS11105	COG3279	Response regulator of the LytR AlgR family
I6K54_RS11110	COG3275	phosphorelay sensor kinase activity
I6K54_RS11125	COG0436	Aminotransferase
I6K54_RS11135	COG2807	transmembrane transport
I6K54_RS11140	COG0590	tRNA wobble adenosine to inosine editing
I6K54_RS11145	COG0583	DNA-binding transcription factor activity
I6K54_RS11180	COG2885	chlorophyll binding
I6K54_RS11345	COG0582	viral genome integration into host DNA
I6K54_RS11410	COG1061	Type III restriction enzyme res subunit
I6K54_RS11445	COG3179	chitinase
I6K54_RS11475	COG1802	Transcriptional regulator
I6K54_RS11475	COG4626	Terminase
I6K54_RS11600	COG2116	formate transmembrane transporter activity
I6K54_RS11605	COG2853	Lipoprotein
I6K54_RS11615	COG3691	Protein conserved in bacteria
I6K54_RS11630	COG2062	phosphohistidine phosphatase, SixA
I6K54_RS11655	COG0730	response to heat
I6K54_RS11660	COG3101	peptidyl-lysine hydroxylation
I6K54_RS11675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K54_RS11695	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K54_RS11705	COG0586	Pfam SNARE associated Golgi protein
I6K54_RS11715	COG0285	dihydrofolate synthase activity
I6K54_RS11720	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K54_RS11725	COG1286	toxin biosynthetic process
I6K54_RS11730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K54_RS11735	COG0163	prenyltransferase activity
I6K54_RS11760	COG4160	amino acid transport
I6K54_RS11765	COG4598	ABC transporter
I6K54_RS11780	COG1090	epimerase
I6K54_RS11785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K54_RS11790	COG0625	glutathione transferase activity
I6K54_RS11795	COG0625	glutathione transferase activity
I6K54_RS11800	COG0622	Phosphoesterase
I6K54_RS11805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K54_RS11810	COG0280	phosphate acetyltransferase
I6K54_RS11810	COG0857	belongs to the CobB CobQ family
I6K54_RS11830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K54_RS11835	COG0471	metal ion transport
I6K54_RS11835	COG0490	domain, Protein
I6K54_RS11845	COG0436	Aminotransferase
I6K54_RS11850	COG0583	DNA-binding transcription factor activity
I6K54_RS11895	COG0839	Belongs to the complex I subunit 6 family
I6K54_RS11905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K54_RS11910	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K54_RS11925	COG2153	protein acetylation
I6K54_RS11930	COG1169	isochorismate synthase
I6K54_RS11955	COG0318	PFAM AMP-dependent synthetase and ligase
I6K54_RS11965	COG5464	transposase or invertase
I6K54_RS11980	COG1414	Transcriptional regulator
I6K54_RS11990	COG2271	Major facilitator Superfamily
I6K54_RS12000	COG0247	lactate metabolic process
I6K54_RS12010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K54_RS12015	COG2271	Major facilitator Superfamily
I6K54_RS12020	COG0584	glycerophosphoryl diester phosphodiesterase
I6K54_RS12025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K54_RS12050	COG2205	protein histidine kinase activity
I6K54_RS12050	COG0784	Response regulator, receiver
I6K54_RS12060	COG0642	Histidine kinase
I6K54_RS12060	COG2198	Histidine kinase
I6K54_RS12075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K54_RS12075	COG2169	Transcriptional regulator
I6K54_RS12080	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K54_RS12085	COG4615	Cyclic peptide transporter
I6K54_RS12090	COG2239	Acts as a magnesium transporter
I6K54_RS12095	COG0659	secondary active sulfate transmembrane transporter activity
I6K54_RS12110	COG0628	permease
I6K54_RS12135	COG1349	DNA-binding transcription factor activity
I6K54_RS12140	COG0494	nUDIX hydrolase
I6K54_RS12160	COG1061	Type III restriction enzyme res subunit
I6K54_RS12165	COG1187	pseudouridine synthase activity
I6K54_RS12170	COG2814	Major facilitator Superfamily
I6K54_RS12180	COG4172	Belongs to the ABC transporter superfamily
I6K54_RS12185	COG4239	(ABC) transporter, permease
I6K54_RS12190	COG4174	ABC transporter (Permease)
I6K54_RS12195	COG4166	transmembrane transport
I6K54_RS12200	COG2200	EAL domain
I6K54_RS12205	COG0791	NLP P60 protein
I6K54_RS12210	COG0671	phosphoesterase, PA-phosphatase related
I6K54_RS12215	COG0523	cobalamin synthesis protein
I6K54_RS12220	COG0246	Mannitol dehydrogenase
I6K54_RS12225	COG1312	Catalyzes the dehydration of D-mannonate
I6K54_RS12245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS12245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS12250	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K54_RS12255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K54_RS12255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K54_RS12255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K54_RS12265	COG2855	membrane
I6K54_RS12270	COG0583	DNA-binding transcription factor activity
I6K54_RS12275	COG0833	amino acid
I6K54_RS12280	COG4771	TonB-dependent receptor
I6K54_RS12295	COG2311	Membrane
I6K54_RS12310	COG1129	ABC transporter
I6K54_RS12320	COG2949	membrane
I6K54_RS12330	COG1346	cytolysis
I6K54_RS12340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K54_RS12345	COG3659	wide pore channel activity
I6K54_RS12360	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS12370	COG1538	Outer membrane efflux protein
I6K54_RS12375	COG0586	Pfam SNARE associated Golgi protein
I6K54_RS12385	COG1686	Belongs to the peptidase S11 family
I6K54_RS12395	COG0277	FAD linked oxidase domain protein
I6K54_RS12400	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K54_RS12405	COG1732	Glycine betaine
I6K54_RS12410	COG1174	glycine betaine transport
I6K54_RS12415	COG1125	glycine betaine transport
I6K54_RS12420	COG1174	glycine betaine transport
I6K54_RS12430	COG3275	phosphorelay sensor kinase activity
I6K54_RS12440	COG4807	Protein conserved in bacteria
I6K54_RS12460	COG5455	response to cobalt ion
I6K54_RS12465	COG0583	DNA-binding transcription factor activity
I6K54_RS12470	COG2252	PERMEase
I6K54_RS12480	COG0583	DNA-binding transcription factor activity
I6K54_RS12565	COG0351	phosphomethylpyrimidine kinase
I6K54_RS12570	COG1830	Aldolase
I6K54_RS12605	COG1070	Carbohydrate kinase
I6K54_RS12615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K54_RS12620	COG4948	Mandelate Racemase Muconate Lactonizing
I6K54_RS12625	COG0747	negative chemotaxis
I6K54_RS12630	COG0601	transmembrane transport
I6K54_RS12635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K54_RS12640	COG0444	Belongs to the ABC transporter superfamily
I6K54_RS12645	COG4608	Belongs to the ABC transporter superfamily
I6K54_RS12655	COG0826	peptidase U32
I6K54_RS12660	COG0745	RESPONSE REGULATOR receiver
I6K54_RS12665	COG2205	protein histidine kinase activity
I6K54_RS12690	COG1301	dicarboxylic acid transport
I6K54_RS12710	COG5002	protein histidine kinase activity
I6K54_RS12715	COG0443	Heat shock 70 kDa protein
I6K54_RS12720	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K54_RS12735	COG2982	Protein involved in outer membrane biogenesis
I6K54_RS12740	COG1253	flavin adenine dinucleotide binding
I6K54_RS12790	COG0438	transferase activity, transferring glycosyl groups
I6K54_RS12875	COG0438	transferase activity, transferring glycosyl groups
I6K54_RS12885	COG1216	Glycosyl transferase, family 2
I6K54_RS12885	COG1442	glycosyl transferase family 8
I6K54_RS12895	COG0463	Glycosyl transferase, family 2
I6K54_RS12920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K54_RS12950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K54_RS12955	COG0583	DNA-binding transcription factor activity
I6K54_RS12965	COG0531	amino acid
I6K54_RS12970	COG0640	Transcriptional regulator
I6K54_RS12975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K54_RS12980	COG2925	Exonuclease
I6K54_RS12995	COG1289	transmembrane transporter activity
I6K54_RS13015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K54_RS13025	COG1942	4-Oxalocrotonate Tautomerase
I6K54_RS13030	COG0583	DNA-binding transcription factor activity
I6K54_RS13035	COG0095	Lipoate-protein ligase
I6K54_RS13040	COG0477	Major facilitator Superfamily
I6K54_RS13050	COG3300	MHYT domain
I6K54_RS13050	COG5001	Diguanylate cyclase
I6K54_RS13060	COG3615	Tellurite resistance protein tehB
I6K54_RS13085	COG3706	GGDEF domain
I6K54_RS13100	COG0534	Mate efflux family protein
I6K54_RS13110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K54_RS13130	COG0604	alcohol dehydrogenase
I6K54_RS13135	COG1309	transcriptional regulator
I6K54_RS13140	COG0025	NhaP-type Na H and K H
I6K54_RS13185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K54_RS13195	COG1418	mRNA catabolic process
I6K54_RS13200	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K54_RS13205	COG3727	T/G mismatch-specific endonuclease activity
I6K54_RS13210	COG0697	spore germination
I6K54_RS13215	COG2354	Protein conserved in bacteria
I6K54_RS13245	COG0366	Alpha amylase catalytic
I6K54_RS13250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS13260	COG0765	amino acid transport
I6K54_RS13265	COG1126	abc transporter atp-binding protein
I6K54_RS13270	COG2197	response regulator
I6K54_RS13280	COG2197	response regulator
I6K54_RS13315	COG3012	SEC-C Motif Domain Protein
I6K54_RS13315	COG3318	Belongs to the UPF0149 family
I6K54_RS13320	COG0814	amino acid
I6K54_RS13330	COG1528	Iron-storage protein
I6K54_RS13345	COG0477	Major facilitator Superfamily
I6K54_RS13355	COG2211	Major facilitator Superfamily
I6K54_RS13365	COG1528	Iron-storage protein
I6K54_RS13375	COG1879	ABC-type sugar transport system periplasmic component
I6K54_RS13385	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS13410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K54_RS13420	COG3102	Protein conserved in bacteria
I6K54_RS13440	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K54_RS13445	COG1801	Protein of unknown function DUF72
I6K54_RS13450	COG1335	isochorismatase
I6K54_RS13465	COG0494	nUDIX hydrolase
I6K54_RS13490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K54_RS13500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K54_RS13505	COG0739	heme binding
I6K54_RS13510	COG1560	Kdo2-lipid A biosynthetic process
I6K54_RS13520	COG1737	Transcriptional regulator
I6K54_RS13530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K54_RS13535	COG0129	dihydroxy-acid dehydratase activity
I6K54_RS13540	COG0800	Aldolase
I6K54_RS13555	COG3141	response to X-ray
I6K54_RS13560	COG2979	Protein of unknown function (DUF533)
I6K54_RS13565	COG1770	oligopeptidase
I6K54_RS13570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K54_RS13580	COG2372	response to copper ion
I6K54_RS13585	COG1276	copper resistance
I6K54_RS13600	COG2990	Protein conserved in bacteria
I6K54_RS13625	COG3008	intermembrane lipid transfer
I6K54_RS13630	COG2995	paraquat-inducible protein a
I6K54_RS13635	COG1956	GAF domain-containing protein
I6K54_RS13655	COG2814	Major facilitator Superfamily
I6K54_RS13660	COG1414	Transcriptional regulator
I6K54_RS13690	COG0768	penicillin binding
I6K54_RS13695	COG2226	methyltransferase
I6K54_RS13710	COG3716	PTS system mannose fructose sorbose family IID component
I6K54_RS13715	COG3715	PTS system
I6K54_RS13720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS13720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K54_RS13725	COG1253	flavin adenine dinucleotide binding
I6K54_RS13730	COG2200	EAL domain
I6K54_RS13735	COG1760	l-serine dehydratase
I6K54_RS13755	COG0251	oxidation-reduction process
I6K54_RS13760	COG1199	ATP-dependent helicase activity
I6K54_RS13770	COG3065	identical protein binding
I6K54_RS13780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K54_RS13790	COG2894	cell division
I6K54_RS13805	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K54_RS13835	COG2719	SpoVR family
I6K54_RS13865	COG4974	Belongs to the 'phage' integrase family
I6K54_RS13935	COG4695	Portal protein
I6K54_RS14090	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K54_RS14100	COG4774	siderophore transport
I6K54_RS14115	COG2308	Evidence 4 Homologs of previously reported genes of
I6K54_RS14155	COG0583	DNA-binding transcription factor activity
I6K54_RS14160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K54_RS14175	COG1882	Formate acetyltransferase
I6K54_RS14210	COG0583	DNA-binding transcription factor activity
I6K54_RS14240	COG0583	DNA-binding transcription factor activity
I6K54_RS14255	COG3122	Protein conserved in bacteria
I6K54_RS14275	COG2885	chlorophyll binding
I6K54_RS14345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K54_RS14435	COG0012	GTP binding
I6K54_RS14455	COG0659	secondary active sulfate transmembrane transporter activity
I6K54_RS14485	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K54_RS14505	COG0387	Pfam Sodium calcium exchanger
I6K54_RS14510	COG4572	Cation transport regulator
I6K54_RS14515	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K54_RS14525	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K54_RS14530	COG3707	response regulator
I6K54_RS14535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K54_RS14545	COG1116	anion transmembrane transporter activity
I6K54_RS14550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K54_RS14550	COG2146	nitrite reductase [NAD(P)H] activity
I6K54_RS14555	COG0243	molybdopterin cofactor binding
I6K54_RS14560	COG4932	domain protein
I6K54_RS14565	COG2197	response regulator
I6K54_RS14570	COG3850	Histidine kinase
I6K54_RS14575	COG2223	nitrite transmembrane transporter activity
I6K54_RS14585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K54_RS14590	COG1140	nitrate reductase beta subunit
I6K54_RS14595	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K54_RS14600	COG2181	nitrate reductase activity
I6K54_RS14610	COG1522	sequence-specific DNA binding
I6K54_RS14645	COG0788	formyltetrahydrofolate deformylase activity
I6K54_RS14655	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K54_RS14660	COG0745	RESPONSE REGULATOR receiver
I6K54_RS14665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K54_RS14670	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K54_RS14680	COG1435	thymidine kinase activity
I6K54_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS14685	COG1454	alcohol dehydrogenase
I6K54_RS14695	COG2095	MarC family integral membrane protein
I6K54_RS14700	COG4166	transmembrane transport
I6K54_RS14705	COG0601	transmembrane transport
I6K54_RS14710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K54_RS14715	COG0444	Belongs to the ABC transporter superfamily
I6K54_RS14725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K54_RS14745	COG2353	YceI-like domain
I6K54_RS14755	COG2350	Protein conserved in bacteria
I6K54_RS14765	COG3001	Fructosamine kinase
I6K54_RS14775	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K54_RS14780	COG3137	Salt-induced outer membrane protein
I6K54_RS14820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K54_RS14820	COG0072	phenylalanine-tRNA ligase activity
I6K54_RS14840	COG0583	DNA-binding transcription factor activity
I6K54_RS14860	COG0386	Belongs to the glutathione peroxidase family
I6K54_RS14870	COG0791	NLP P60 protein
I6K54_RS14880	COG4256	Hemin uptake protein
I6K54_RS14885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K54_RS14900	COG0574	Belongs to the PEP-utilizing enzyme family
I6K54_RS14900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K54_RS14910	COG0628	permease
I6K54_RS14915	COG0277	FAD linked oxidase domain protein
I6K54_RS14915	COG0247	lactate metabolic process
I6K54_RS14920	COG2050	protein possibly involved in aromatic compounds catabolism
I6K54_RS14925	COG2261	transglycosylase associated protein
I6K54_RS14950	COG1120	ATPase activity
I6K54_RS14955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS14965	COG0583	DNA-binding transcription factor activity
I6K54_RS14990	COG1304	FMN binding
I6K54_RS15005	COG0316	Belongs to the HesB IscA family
I6K54_RS15010	COG0719	Fe-S assembly protein
I6K54_RS15015	COG0396	ATPase activity
I6K54_RS15020	COG0719	Fe-S assembly protein
I6K54_RS15035	COG1376	ErfK ybiS ycfS ynhG family protein
I6K54_RS15065	COG1309	transcriptional regulator
I6K54_RS15070	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K54_RS15070	COG1082	Xylose isomerase domain protein TIM barrel
I6K54_RS15075	COG2271	Major facilitator Superfamily
I6K54_RS15080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K54_RS15090	COG1120	ATPase activity
I6K54_RS15095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS15100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K54_RS15105	COG1414	Transcriptional regulator
I6K54_RS15140	COG2814	Major facilitator Superfamily
I6K54_RS15160	COG0583	DNA-binding transcription factor activity
I6K54_RS15165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K54_RS15185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K54_RS15190	COG1116	anion transmembrane transporter activity
I6K54_RS15195	COG4774	siderophore transport
I6K54_RS15200	COG1120	ATPase activity
I6K54_RS15205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS15210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS15230	COG0765	amino acid transport
I6K54_RS15235	COG1126	abc transporter atp-binding protein
I6K54_RS15275	COG3383	formate dehydrogenase (NAD+) activity
I6K54_RS15280	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K54_RS15290	COG1175	transmembrane transport
I6K54_RS15320	COG4133	protoheme IX ABC transporter activity
I6K54_RS15325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K54_RS15330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K54_RS15345	COG1138	Cytochrome C-type biogenesis protein
I6K54_RS15350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K54_RS15355	COG4235	cytochrome complex assembly
I6K54_RS15355	COG3088	subunit of a heme lyase
I6K54_RS15375	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K54_RS15390	COG3850	Histidine kinase
I6K54_RS15390	COG5002	protein histidine kinase activity
I6K54_RS15395	COG0745	RESPONSE REGULATOR receiver
I6K54_RS15410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K54_RS15445	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS15450	COG2610	gluconate transmembrane transporter activity
I6K54_RS15455	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K54_RS15465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K54_RS15475	COG0583	DNA-binding transcription factor activity
I6K54_RS15510	COG2814	Major facilitator Superfamily
I6K54_RS15525	COG0277	FAD linked oxidase domain protein
I6K54_RS15530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K54_RS15555	COG0402	S-adenosylhomocysteine deaminase activity
I6K54_RS15610	COG4608	Belongs to the ABC transporter superfamily
I6K54_RS15615	COG0444	Belongs to the ABC transporter superfamily
I6K54_RS15640	COG0346	lactoylglutathione lyase activity
I6K54_RS15645	COG1349	DNA-binding transcription factor activity
I6K54_RS15680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K54_RS15735	COG0307	riboflavin synthase, alpha
I6K54_RS15740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K54_RS15745	COG2814	Major facilitator Superfamily
I6K54_RS15750	COG0583	DNA-binding transcription factor activity
I6K54_RS15765	COG2814	Major facilitator Superfamily
I6K54_RS15780	COG0791	NLP P60 protein
I6K54_RS15785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K54_RS15795	COG0346	lactoylglutathione lyase activity
I6K54_RS15800	COG1902	pentaerythritol trinitrate reductase activity
I6K54_RS15805	COG1309	transcriptional regulator
I6K54_RS15810	COG3313	Fe-S protein
I6K54_RS15815	COG4989	oxidoreductase activity
I6K54_RS15820	COG2032	superoxide dismutase activity
I6K54_RS15825	COG1289	transmembrane transporter activity
I6K54_RS15830	COG1566	PFAM secretion protein HlyD family protein
I6K54_RS15845	COG3706	GGDEF domain
I6K54_RS15860	COG3895	Periplasmic Protein
I6K54_RS15875	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K54_RS15880	COG0625	glutathione transferase activity
I6K54_RS15890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K54_RS15900	COG4659	FMN binding
I6K54_RS15935	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS15945	COG0673	inositol 2-dehydrogenase activity
I6K54_RS15955	COG2814	Major facilitator Superfamily
I6K54_RS15975	COG3038	cytochrome b561
I6K54_RS15995	COG0583	DNA-binding transcription factor activity
I6K54_RS16000	COG3485	protocatechuate 3,4-dioxygenase
I6K54_RS16005	COG3485	protocatechuate 3,4-dioxygenase
I6K54_RS16010	COG5383	Protein conserved in bacteria
I6K54_RS16015	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K54_RS16030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K54_RS16035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K54_RS16040	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K54_RS16045	COG0500	methyltransferase
I6K54_RS16060	COG3708	Transcriptional regulator
I6K54_RS16060	COG2207	Transcriptional regulator
I6K54_RS16065	COG3135	benzoate transporter
I6K54_RS16070	COG1396	sequence-specific DNA binding
I6K54_RS16080	COG0826	peptidase U32
I6K54_RS16100	COG1294	oxidase, subunit
I6K54_RS16105	COG1271	oxidase subunit
I6K54_RS16110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K54_RS16115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K54_RS16120	COG3842	ATPase activity
I6K54_RS16125	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K54_RS16130	COG1177	transmembrane transport
I6K54_RS16135	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS16170	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS16175	COG0747	negative chemotaxis
I6K54_RS16185	COG3238	Protein conserved in bacteria
I6K54_RS16190	COG1247	-acetyltransferase
I6K54_RS16200	COG2130	NADP-dependent
I6K54_RS16210	COG3691	Protein conserved in bacteria
I6K54_RS16215	COG1228	amidohydrolase
I6K54_RS16220	COG4772	TonB-dependent receptor
I6K54_RS16245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K54_RS16250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K54_RS16255	COG1473	amidohydrolase
I6K54_RS16260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K54_RS16265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS16275	COG0765	amino acid transport
I6K54_RS16280	COG1126	abc transporter atp-binding protein
I6K54_RS16290	COG0625	glutathione transferase activity
I6K54_RS16315	COG2211	Major facilitator Superfamily
I6K54_RS16330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K54_RS16335	COG3842	ATPase activity
I6K54_RS16340	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K54_RS16345	COG1178	ABC-type Fe3 transport system permease component
I6K54_RS16350	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K54_RS16355	COG2181	nitrate reductase activity
I6K54_RS16360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K54_RS16365	COG1140	nitrate reductase beta subunit
I6K54_RS16370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K54_RS16390	COG1414	Transcriptional regulator
I6K54_RS16395	COG4948	Mandelate Racemase Muconate Lactonizing
I6K54_RS16400	COG4829	muconolactone delta-isomerase
I6K54_RS16405	COG3485	protocatechuate 3,4-dioxygenase
I6K54_RS16415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K54_RS16440	COG0437	4 iron, 4 sulfur cluster binding
I6K54_RS16445	COG2864	formate dehydrogenase
I6K54_RS16460	COG2326	polyphosphate kinase activity
I6K54_RS16470	COG2814	Major facilitator Superfamily
I6K54_RS16480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K54_RS16490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K54_RS16500	COG0747	negative chemotaxis
I6K54_RS16505	COG1064	alcohol dehydrogenase
I6K54_RS16520	COG0488	(ABC) transporter
I6K54_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS16570	COG3729	General stress protein
I6K54_RS16580	COG3685	Protein conserved in bacteria
I6K54_RS16590	COG0366	Alpha amylase catalytic
I6K54_RS16600	COG2323	membrane
I6K54_RS16610	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K54_RS16620	COG1764	response to oxidative stress
I6K54_RS16645	COG3781	membrane
I6K54_RS16650	COG0243	molybdopterin cofactor binding
I6K54_RS16655	COG0583	DNA-binding transcription factor activity
I6K54_RS16660	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K54_RS16665	COG2814	Major facilitator Superfamily
I6K54_RS16670	COG1285	pathogenesis
I6K54_RS16675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K54_RS16685	COG0583	DNA-binding transcription factor activity
I6K54_RS16705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K54_RS16705	COG0519	Catalyzes the synthesis of GMP from XMP
I6K54_RS16745	COG0596	Alpha beta hydrolase
I6K54_RS16755	COG2205	protein histidine kinase activity
I6K54_RS16770	COG0076	glutamate decarboxylase activity
I6K54_RS16775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K54_RS16780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K54_RS16785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K54_RS16790	COG1116	anion transmembrane transporter activity
I6K54_RS16795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K54_RS16810	COG0673	inositol 2-dehydrogenase activity
I6K54_RS16820	COG1609	Transcriptional regulator
I6K54_RS16825	COG3706	GGDEF domain
I6K54_RS16830	COG0402	S-adenosylhomocysteine deaminase activity
I6K54_RS16835	COG1953	Uracil, thiamine, allantoin
I6K54_RS16875	COG0406	alpha-ribazole phosphatase activity
I6K54_RS16905	COG3436	PFAM IS66 Orf2 family protein
I6K54_RS16910	COG4372	Transposase
I6K54_RS16935	COG2207	Transcriptional regulator
I6K54_RS16950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K54_RS17020	COG0765	amino acid transport
I6K54_RS17030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K54_RS17040	COG2070	2-Nitropropane dioxygenase
I6K54_RS17045	COG0583	DNA-binding transcription factor activity
I6K54_RS17055	COG1902	pentaerythritol trinitrate reductase activity
I6K54_RS17060	COG4529	Protein conserved in bacteria
I6K54_RS17065	COG0477	Major facilitator Superfamily
I6K54_RS17110	COG2223	nitrite transmembrane transporter activity
I6K54_RS17120	COG1609	Transcriptional regulator
I6K54_RS17125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS17135	COG3037	sugar-specific permease SgaT UlaA
I6K54_RS17140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K54_RS17150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K54_RS17155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K54_RS17155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K54_RS17155	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K54_RS17170	COG0583	DNA-binding transcription factor activity
I6K54_RS17200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K54_RS17210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K54_RS17225	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS17235	COG1609	Transcriptional regulator
I6K54_RS17265	COG1652	LysM domain
I6K54_RS17290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K54_RS17290	COG0456	acetyltransferase
I6K54_RS17300	COG0667	Aldo Keto reductase
I6K54_RS17305	COG0667	Aldo Keto reductase
I6K54_RS17310	COG3386	PFAM SMP-30 Gluconolaconase
I6K54_RS17315	COG0667	Aldo Keto reductase
I6K54_RS17330	COG2801	Transposase and inactivated derivatives
I6K54_RS17340	COG1473	amidohydrolase
I6K54_RS17355	COG0251	oxidation-reduction process
I6K54_RS17360	COG0583	DNA-binding transcription factor activity
I6K54_RS17365	COG0626	cystathionine gamma-synthase activity
I6K54_RS17370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K54_RS17375	COG0814	amino acid
I6K54_RS17380	COG0583	DNA-binding transcription factor activity
I6K54_RS17390	COG1294	oxidase, subunit
I6K54_RS17395	COG1271	oxidase subunit
I6K54_RS17405	COG3118	belongs to the thioredoxin family
I6K54_RS17435	COG0583	DNA-binding transcription factor activity
I6K54_RS17475	COG1929	Belongs to the glycerate kinase type-1 family
I6K54_RS17480	COG3835	regulator
I6K54_RS17500	COG2186	Transcriptional regulator
I6K54_RS17505	COG1263	PTS System
I6K54_RS17505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K54_RS17515	COG2814	Major facilitator Superfamily
I6K54_RS17520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS17520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS17535	COG2819	hydrolase of the alpha beta superfamily
I6K54_RS17540	COG3300	MHYT domain
I6K54_RS17540	COG5001	Diguanylate cyclase
I6K54_RS17575	COG3188	usher protein
I6K54_RS17585	COG1649	PFAM Uncharacterised BCR, COG1649
I6K54_RS17590	COG3550	peptidyl-serine autophosphorylation
I6K54_RS17595	COG1396	sequence-specific DNA binding
I6K54_RS17600	COG2351	hydroxyisourate hydrolase activity
I6K54_RS17605	COG3648	Uricase
I6K54_RS17605	COG3195	allantoin biosynthetic process
I6K54_RS17610	COG2233	PERMEase
I6K54_RS17640	COG2207	Transcriptional regulator
I6K54_RS17655	COG4628	conserved protein (DUF2132)
I6K54_RS17675	COG2011	ABC-type metal ion transport system permease component
I6K54_RS17680	COG2070	2-Nitropropane dioxygenase
I6K54_RS17690	COG0477	Major facilitator Superfamily
I6K54_RS17755	COG2199	diguanylate cyclase activity
I6K54_RS17770	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS17775	COG0583	DNA-binding transcription factor activity
I6K54_RS17785	COG0039	L-malate dehydrogenase activity
I6K54_RS17825	COG4977	sequence-specific DNA binding
I6K54_RS17835	COG0697	spore germination
I6K54_RS17840	COG2814	Major facilitator Superfamily
I6K54_RS17855	COG1129	ABC transporter
I6K54_RS17875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K54_RS17910	COG2223	nitrite transmembrane transporter activity
I6K54_RS17915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K54_RS17930	COG1349	DNA-binding transcription factor activity
I6K54_RS17935	COG2084	Dehydrogenase
I6K54_RS17940	COG3395	kinase activity
I6K54_RS17945	COG0235	Class ii aldolase
I6K54_RS17950	COG3622	Belongs to the hyi family
I6K54_RS17955	COG2610	gluconate transmembrane transporter activity
I6K54_RS17960	COG2207	Transcriptional regulator
I6K54_RS17960	COG3708	Transcriptional regulator
I6K54_RS17980	COG2200	EAL domain
I6K54_RS17985	COG1546	Belongs to the CinA family
I6K54_RS17990	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K54_RS18025	COG2135	peptidase activity
I6K54_RS18030	COG2207	Transcriptional regulator
I6K54_RS18045	COG4221	oxidoreductase activity
I6K54_RS18050	COG1802	Transcriptional regulator
I6K54_RS18055	COG0589	response to stress
I6K54_RS18060	COG0246	Mannitol dehydrogenase
I6K54_RS18065	COG2271	Major facilitator Superfamily
I6K54_RS18080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K54_RS18100	COG0437	4 iron, 4 sulfur cluster binding
I6K54_RS18105	COG3302	dmso reductase anchor subunit
I6K54_RS18120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K54_RS18125	COG1940	carbohydrate kinase activity
I6K54_RS18130	COG0583	DNA-binding transcription factor activity
I6K54_RS18135	COG2814	Major facilitator Superfamily
I6K54_RS18140	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K54_RS18150	COG3591	Belongs to the peptidase S1B family
I6K54_RS18170	COG0628	permease
I6K54_RS18210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K54_RS18235	COG3290	protein histidine kinase activity
I6K54_RS18240	COG4565	transcriptional regulatory protein
I6K54_RS18260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K54_RS18260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K54_RS18270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K54_RS18275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K54_RS18285	COG0183	Belongs to the thiolase family
I6K54_RS18290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K54_RS18300	COG1414	Transcriptional regulator
I6K54_RS18305	COG2840	Smr protein MutS2
I6K54_RS18310	COG0583	DNA-binding transcription factor activity
I6K54_RS18320	COG1473	amidohydrolase
I6K54_RS18325	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K54_RS18340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K54_RS18355	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K54_RS18360	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K54_RS18375	COG0531	amino acid
I6K54_RS18385	COG3136	membrane protein required for alginate biosynthesis
I6K54_RS18390	COG0745	RESPONSE REGULATOR receiver
I6K54_RS18400	COG2205	protein histidine kinase activity
I6K54_RS18410	COG0114	fumarate hydratase activity
I6K54_RS18415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K54_RS18415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K54_RS18420	COG1482	cell wall glycoprotein biosynthetic process
I6K54_RS18425	COG5339	Protein conserved in bacteria
I6K54_RS18430	COG1609	Transcriptional regulator
I6K54_RS18435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K54_RS18435	COG1263	PTS System
I6K54_RS18440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K54_RS18465	COG2391	methyltransferase activity
I6K54_RS18470	COG0425	Belongs to the sulfur carrier protein TusA family
I6K54_RS18475	COG5562	phage envelope protein
I6K54_RS18480	COG0401	homolog of Blt101
I6K54_RS18485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K54_RS18490	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS18500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K54_RS18510	COG1113	amino acid transport
I6K54_RS18515	COG2988	succinylglutamate desuccinylase activity
I6K54_RS18520	COG3724	N-succinylarginine dihydrolase activity
I6K54_RS18525	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS18530	COG3138	arginine N-succinyltransferase
I6K54_RS18535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K54_RS18545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K54_RS18550	COG0667	Aldo Keto reductase
I6K54_RS18555	COG0583	DNA-binding transcription factor activity
I6K54_RS18580	COG4122	O-methyltransferase activity
I6K54_RS18585	COG1643	Atp-dependent helicase
I6K54_RS18600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K54_RS18605	COG3327	negative regulation of DNA-templated transcription, initiation
I6K54_RS18610	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K54_RS18615	COG0183	Belongs to the thiolase family
I6K54_RS18620	COG2050	protein possibly involved in aromatic compounds catabolism
I6K54_RS18625	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K54_RS18630	COG1024	Enoyl-CoA hydratase
I6K54_RS18635	COG1024	Enoyl-CoA hydratase
I6K54_RS18640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K54_RS18645	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K54_RS18650	COG3396	Phenylacetate-CoA oxygenase
I6K54_RS18655	COG3460	Phenylacetate-CoA oxygenase
I6K54_RS18660	COG3396	Phenylacetate-CoA oxygenase
I6K54_RS18665	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS18665	COG2030	dehydratase
I6K54_RS18685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K54_RS18700	COG2072	flavoprotein involved in K transport
I6K54_RS18705	COG0583	DNA-binding transcription factor activity
I6K54_RS18710	COG1126	abc transporter atp-binding protein
I6K54_RS18720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS18735	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS18740	COG2207	Transcriptional regulator
I6K54_RS18745	COG3784	Protein of unknown function (DUF1318)
I6K54_RS18755	COG2911	Protein conserved in bacteria
I6K54_RS18760	COG0586	Pfam SNARE associated Golgi protein
I6K54_RS18765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K54_RS18770	COG3187	Heat shock protein
I6K54_RS18775	COG3042	response to heat
I6K54_RS18780	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K54_RS18780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K54_RS18780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K54_RS18780	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K54_RS18785	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K54_RS18795	COG0589	response to stress
I6K54_RS18805	COG0513	Belongs to the DEAD box helicase family
I6K54_RS18815	COG1349	DNA-binding transcription factor activity
I6K54_RS18820	COG0673	inositol 2-dehydrogenase activity
I6K54_RS18835	COG1113	amino acid transport
I6K54_RS18840	COG1522	sequence-specific DNA binding
I6K54_RS18850	COG1448	Aminotransferase
I6K54_RS18855	COG2011	ABC-type metal ion transport system permease component
I6K54_RS18870	COG0436	Aminotransferase
I6K54_RS18875	COG0604	alcohol dehydrogenase
I6K54_RS18905	COG0583	DNA-binding transcription factor activity
I6K54_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS18930	COG1309	transcriptional regulator
I6K54_RS18935	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS19040	COG2885	chlorophyll binding
I6K54_RS19065	COG0693	protein deglycase activity
I6K54_RS19070	COG1078	dGTPase activity
I6K54_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS19080	COG0583	DNA-binding transcription factor activity
I6K54_RS19095	COG0656	L-ascorbic acid biosynthetic process
I6K54_RS19125	COG4166	transmembrane transport
I6K54_RS19135	COG2866	Carboxypeptidase
I6K54_RS19140	COG4948	Mandelate Racemase Muconate Lactonizing
I6K54_RS19145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K54_RS19150	COG3180	Ammonia monooxygenase
I6K54_RS19160	COG1486	melibiose metabolic process
I6K54_RS19165	COG0583	DNA-binding transcription factor activity
I6K54_RS19175	COG3106	COG3106 Predicted ATPase
I6K54_RS19185	COG1983	PspC domain protein
I6K54_RS19195	COG1842	Phage shock protein A
I6K54_RS19200	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K54_RS19210	COG1473	amidohydrolase
I6K54_RS19225	COG0702	epimerase
I6K54_RS19240	COG4171	peptide transport system, permease
I6K54_RS19255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K54_RS19265	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K54_RS19270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K54_RS19270	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K54_RS19285	COG1349	DNA-binding transcription factor activity
I6K54_RS19295	COG0023	Translation Initiation Factor
I6K54_RS19305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K54_RS19310	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K54_RS19315	COG0671	phosphoesterase, PA-phosphatase related
I6K54_RS19325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K54_RS19350	COG0616	signal peptide processing
I6K54_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS19365	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K54_RS19375	COG0583	DNA-binding transcription factor activity
I6K54_RS19385	COG0009	L-threonylcarbamoyladenylate synthase
I6K54_RS19395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K54_RS19400	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K54_RS19400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K54_RS19405	COG0134	indole-3-glycerol-phosphate synthase activity
I6K54_RS19405	COG0135	phosphoribosylanthranilate isomerase activity
I6K54_RS19440	COG4774	siderophore transport
I6K54_RS19450	COG3047	cAMP biosynthetic process
I6K54_RS19455	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K54_RS19485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K54_RS19490	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS19495	COG1988	membrane-bound metal-dependent
I6K54_RS19500	COG1823	symporter activity
I6K54_RS19510	COG0753	catalase activity
I6K54_RS19520	COG1486	melibiose metabolic process
I6K54_RS19525	COG1917	Cupin 2, conserved barrel domain protein
I6K54_RS19525	COG2169	Transcriptional regulator
I6K54_RS19530	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K54_RS19535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS19545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K54_RS19550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K54_RS19560	COG0322	excinuclease ABC activity
I6K54_RS19565	COG3678	ATP-independent chaperone mediated protein folding
I6K54_RS19575	COG3724	N-succinylarginine dihydrolase activity
I6K54_RS19585	COG3138	arginine N-succinyltransferase
I6K54_RS19595	COG0708	Exodeoxyribonuclease III
I6K54_RS19600	COG0398	Pfam SNARE associated Golgi protein
I6K54_RS19605	COG0398	Pfam SNARE associated Golgi protein
I6K54_RS19610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K54_RS19615	COG4134	Bacterial extracellular solute-binding protein
I6K54_RS19620	COG4135	transport system, permease component
I6K54_RS19625	COG4136	ATPase activity
I6K54_RS19630	COG2897	thiosulfate sulfurtransferase activity
I6K54_RS19635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K54_RS19640	COG0494	nUDIX hydrolase
I6K54_RS19645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K54_RS19650	COG3321	synthase
I6K54_RS19650	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS19650	COG0604	alcohol dehydrogenase
I6K54_RS19655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K54_RS19660	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K54_RS19670	COG0778	Nitroreductase
I6K54_RS19675	COG0616	signal peptide processing
I6K54_RS19680	COG0252	asparaginase activity
I6K54_RS19685	COG1335	isochorismatase
I6K54_RS19700	COG3139	Protein of unknown function (DUF1315)
I6K54_RS19720	COG0656	L-ascorbic acid biosynthetic process
I6K54_RS19725	COG3713	MltA-interacting MipA family protein
I6K54_RS19730	COG2766	serine protein kinase
I6K54_RS19745	COG0386	Belongs to the glutathione peroxidase family
I6K54_RS19770	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS19775	COG0583	DNA-binding transcription factor activity
I6K54_RS19780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K54_RS19785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K54_RS19800	COG0859	PFAM glycosyl transferase family 9
I6K54_RS19805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K54_RS19815	COG2207	Transcriptional regulator
I6K54_RS19820	COG2807	transmembrane transport
I6K54_RS19825	COG0504	CTP synthase activity
I6K54_RS19830	COG1683	Conserved Protein
I6K54_RS19835	COG3189	MarR family transcriptional regulator
I6K54_RS19840	COG3042	response to heat
I6K54_RS19845	COG2203	Gaf domain
I6K54_RS19845	COG2199	diguanylate cyclase activity
I6K54_RS19865	COG3182	Iron-regulated membrane protein
I6K54_RS19875	COG1560	Kdo2-lipid A biosynthetic process
I6K54_RS19885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K54_RS19890	COG3706	GGDEF domain
I6K54_RS19895	COG0583	DNA-binding transcription factor activity
I6K54_RS19900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K54_RS19930	COG1294	oxidase, subunit
I6K54_RS19935	COG1271	oxidase subunit
I6K54_RS19940	COG3546	catalase activity
I6K54_RS19945	COG3685	Protein conserved in bacteria
I6K54_RS19950	COG3685	Protein conserved in bacteria
I6K54_RS19955	COG3729	General stress protein
I6K54_RS20050	COG1802	Transcriptional regulator
I6K54_RS20050	COG4626	Terminase
I6K54_RS20075	COG3772	lysozyme
I6K54_RS20100	COG1403	HNH endonuclease
I6K54_RS20105	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K54_RS20135	COG1396	sequence-specific DNA binding
I6K54_RS20205	COG0582	viral genome integration into host DNA
I6K54_RS20210	COG0538	isocitrate dehydrogenase activity
I6K54_RS20215	COG1187	pseudouridine synthase activity
I6K54_RS20235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K54_RS20255	COG2205	protein histidine kinase activity
I6K54_RS20260	COG2850	peptidyl-arginine hydroxylation
I6K54_RS20280	COG1177	transmembrane transport
I6K54_RS20295	COG0318	PFAM AMP-dependent synthetase and ligase
I6K54_RS20300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K54_RS20305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K54_RS20310	COG0698	ribose 5-phosphate isomerase
I6K54_RS20325	COG3395	kinase activity
I6K54_RS20340	COG2390	Transcriptional regulator
I6K54_RS20350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K54_RS20360	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K54_RS20370	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K54_RS20380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K54_RS20385	COG1376	ErfK ybiS ycfS ynhG family protein
I6K54_RS20385	COG1388	LysM domain
I6K54_RS20400	COG1309	transcriptional regulator
I6K54_RS20415	COG3134	Outer membrane lipoprotein
I6K54_RS20420	COG1252	NADH dehydrogenase
I6K54_RS20445	COG5633	Lipoprotein
I6K54_RS20450	COG0537	adenosine 5'-monophosphoramidase activity
I6K54_RS20460	COG0084	hydrolase, TatD family'
I6K54_RS20465	COG0470	DNA polymerase III
I6K54_RS20475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K54_RS20480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K54_RS20485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K54_RS20500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K54_RS20520	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K54_RS20540	COG1530	ribonuclease E activity
I6K54_RS20545	COG0583	DNA-binding transcription factor activity
I6K54_RS20550	COG2814	Major facilitator Superfamily
I6K54_RS20570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K54_RS20615	COG1560	Kdo2-lipid A biosynthetic process
I6K54_RS20630	COG5645	(Lipo)protein
I6K54_RS20665	COG3381	protein complex oligomerization
I6K54_RS20765	COG1309	transcriptional regulator
I6K54_RS20770	COG0583	DNA-binding transcription factor activity
I6K54_RS20780	COG1335	isochorismatase
I6K54_RS20805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K54_RS20810	COG1702	phosphate starvation-inducible protein PhoH
I6K54_RS20830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K54_RS20840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K54_RS20855	COG1309	transcriptional regulator
I6K54_RS20890	COG2233	PERMEase
I6K54_RS20900	COG3729	General stress protein
I6K54_RS21060	COG4695	Portal protein
I6K54_RS21150	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS21165	COG0531	amino acid
I6K54_RS21170	COG0174	glutamine synthetase
I6K54_RS21175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K54_RS21180	COG1396	sequence-specific DNA binding
I6K54_RS21180	COG1917	Cupin 2, conserved barrel domain protein
I6K54_RS21185	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS21190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K54_RS21195	COG0583	DNA-binding transcription factor activity
I6K54_RS21200	COG0473	3-isopropylmalate dehydrogenase activity
I6K54_RS21205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K54_RS21210	COG4638	Rieske (2fe-2S)
I6K54_RS21215	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS21220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K54_RS21240	COG0670	Belongs to the BI1 family
I6K54_RS21255	COG2207	Transcriptional regulator
I6K54_RS21260	COG1881	PFAM PEBP family protein
I6K54_RS21285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS21290	COG2274	protein secretion by the type I secretion system
I6K54_RS21325	COG1832	CoA-binding protein
I6K54_RS21335	COG0210	DNA helicase
I6K54_RS21340	COG3304	Inner membrane component domain
I6K54_RS21345	COG1289	transmembrane transporter activity
I6K54_RS21350	COG3070	regulator of competence-specific genes
I6K54_RS21370	COG1067	ATP-dependent peptidase activity
I6K54_RS21380	COG3130	regulation of translation
I6K54_RS21385	COG3009	Protein conserved in bacteria
I6K54_RS21390	COG3008	intermembrane lipid transfer
I6K54_RS21390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K54_RS21395	COG2995	paraquat-inducible protein a
I6K54_RS21400	COG0488	(ABC) transporter
I6K54_RS21410	COG3217	Mosc domain protein beta barrel domain protein
I6K54_RS21410	COG0633	Ferredoxin
I6K54_RS21425	COG0431	NADPH-dependent FMN reductase
I6K54_RS21430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K54_RS21435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K54_RS21440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K54_RS21450	COG0308	aminopeptidase N
I6K54_RS21460	COG1473	amidohydrolase
I6K54_RS21470	COG0814	amino acid
I6K54_RS21490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K54_RS21495	COG1448	Aminotransferase
I6K54_RS21500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K54_RS21505	COG3108	Peptidase M15
I6K54_RS21510	COG2989	Protein conserved in bacteria
I6K54_RS21520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K54_RS21530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K54_RS21535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K54_RS21540	COG3173	Aminoglycoside phosphotransferase
I6K54_RS21555	COG3214	Protein conserved in bacteria
I6K54_RS21570	COG2333	competence protein COMEC
I6K54_RS21570	COG0658	competence protein
I6K54_RS21580	COG0539	negative regulation of cytoplasmic translation
I6K54_RS21600	COG2323	membrane
I6K54_RS21605	COG1944	ATP diphosphatase activity
I6K54_RS21610	COG2116	formate transmembrane transporter activity
I6K54_RS21615	COG1882	Formate acetyltransferase
I6K54_RS21620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K54_RS21625	COG0477	Major facilitator Superfamily
I6K54_RS21630	COG3302	dmso reductase anchor subunit
I6K54_RS21635	COG0437	4 iron, 4 sulfur cluster binding
I6K54_RS21640	COG0243	molybdopterin cofactor binding
I6K54_RS21650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K54_RS21660	COG1178	ABC-type Fe3 transport system permease component
I6K54_RS21660	COG1674	ftsk spoiiie
I6K54_RS21670	COG0492	ferredoxin-NADP+ reductase activity
I6K54_RS21675	COG4988	ABC transporter
I6K54_RS21680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K54_RS21695	COG0542	response to heat
I6K54_RS21705	COG1278	Cold shock
I6K54_RS21715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS21720	COG3593	DNA synthesis involved in DNA repair
I6K54_RS21730	COG2431	L-lysine efflux transmembrane transporter activity
I6K54_RS21740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K54_RS21750	COG0028	Belongs to the TPP enzyme family
I6K54_RS21755	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K54_RS21760	COG0702	epimerase
I6K54_RS21765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K54_RS21770	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K54_RS21775	COG5001	Diguanylate cyclase
I6K54_RS21775	COG4251	negative regulation of phosphorylation
I6K54_RS21775	COG3706	GGDEF domain
I6K54_RS21775	COG2203	Gaf domain
I6K54_RS21785	COG1126	abc transporter atp-binding protein
I6K54_RS21790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS21795	COG4215	(ABC) transporter
I6K54_RS21800	COG4160	amino acid transport
I6K54_RS21805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS21810	COG5002	protein histidine kinase activity
I6K54_RS21815	COG0745	RESPONSE REGULATOR receiver
I6K54_RS21830	COG1177	transmembrane transport
I6K54_RS21835	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K54_RS21840	COG3842	ATPase activity
I6K54_RS21845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K54_RS21860	COG0778	Nitroreductase
I6K54_RS21915	COG3226	Transcriptional regulator
I6K54_RS21920	COG0738	Major facilitator superfamily
I6K54_RS21925	COG0561	phosphatase activity
I6K54_RS21930	COG2814	Major facilitator Superfamily
I6K54_RS21935	COG0671	phosphoesterase, PA-phosphatase related
I6K54_RS21940	COG1349	DNA-binding transcription factor activity
I6K54_RS21945	COG1686	Belongs to the peptidase S11 family
I6K54_RS21955	COG0625	glutathione transferase activity
I6K54_RS21960	COG2133	pyrroloquinoline quinone binding
I6K54_RS21970	COG2223	nitrite transmembrane transporter activity
I6K54_RS21990	COG0747	negative chemotaxis
I6K54_RS22005	COG0303	'Molybdopterin
I6K54_RS22010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K54_RS22015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K54_RS22020	COG1882	Formate acetyltransferase
I6K54_RS22025	COG0561	phosphatase activity
I6K54_RS22035	COG1609	Transcriptional regulator
I6K54_RS22040	COG2271	Major facilitator Superfamily
I6K54_RS22050	COG0488	(ABC) transporter
I6K54_RS22055	COG2365	Tyrosine phosphatase family
I6K54_RS22060	COG1376	ErfK ybiS ycfS ynhG family protein
I6K54_RS22065	COG2188	Transcriptional regulator
I6K54_RS22070	COG2723	6-phospho-beta-galactosidase activity
I6K54_RS22075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K54_RS22090	COG2194	sulfuric ester hydrolase activity
I6K54_RS22095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K54_RS22110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS22115	COG0765	amino acid transport
I6K54_RS22120	COG1126	abc transporter atp-binding protein
I6K54_RS22125	COG0668	transmembrane transport
I6K54_RS22135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K54_RS22145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K54_RS22155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K54_RS22160	COG1199	ATP-dependent helicase activity
I6K54_RS22165	COG0513	Belongs to the DEAD box helicase family
I6K54_RS22170	COG3958	Transketolase
I6K54_RS22175	COG3959	Transketolase, thiamine diphosphate binding domain
I6K54_RS22180	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS22185	COG2271	Major facilitator Superfamily
I6K54_RS22195	COG0583	DNA-binding transcription factor activity
I6K54_RS22200	COG1309	transcriptional regulator
I6K54_RS22205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS22210	COG1131	(ABC) transporter
I6K54_RS22215	COG0842	Transport permease protein
I6K54_RS22220	COG0842	Transport permease protein
I6K54_RS22230	COG3568	Endonuclease Exonuclease Phosphatase
I6K54_RS22235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K54_RS22240	COG0392	lysyltransferase activity
I6K54_RS22245	COG0670	Belongs to the BI1 family
I6K54_RS22250	COG0314	molybdopterin synthase activity
I6K54_RS22255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K54_RS22265	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K54_RS22285	COG0745	RESPONSE REGULATOR receiver
I6K54_RS22290	COG0642	Histidine kinase
I6K54_RS22315	COG2226	methyltransferase
I6K54_RS22330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K54_RS22335	COG1881	PFAM PEBP family protein
I6K54_RS22375	COG4677	pectinesterase activity
I6K54_RS22385	COG0589	response to stress
I6K54_RS22390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS22425	COG0789	Transcriptional regulator
I6K54_RS22430	COG2200	EAL domain
I6K54_RS22455	COG0561	phosphatase activity
I6K54_RS22460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K54_RS22465	COG4149	molybdate abc transporter
I6K54_RS22470	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K54_RS22480	COG3585	molybdate ion transport
I6K54_RS22480	COG2005	Transcriptional regulator
I6K54_RS22485	COG1119	ATPase activity
I6K54_RS22495	COG1085	galactose-1-phosphate uridylyltransferase
I6K54_RS22505	COG2017	converts alpha-aldose to the beta-anomer
I6K54_RS22515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K54_RS22530	COG3201	nicotinamide mononucleotide transporter
I6K54_RS22535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K54_RS22580	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K54_RS22585	COG2885	chlorophyll binding
I6K54_RS22595	COG3064	Membrane
I6K54_RS22600	COG0848	biopolymer transport protein
I6K54_RS22605	COG0811	peptide transport
I6K54_RS22610	COG0824	Thioesterase
I6K54_RS22615	COG3790	cyd operon protein YbgE
I6K54_RS22620	COG4890	Cyd operon protein YbgT
I6K54_RS22625	COG1294	oxidase, subunit
I6K54_RS22630	COG1271	oxidase subunit
I6K54_RS22635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K54_RS22645	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K54_RS22650	COG0567	Dehydrogenase, E1 component
I6K54_RS22655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K54_RS22660	COG1053	succinate dehydrogenase
I6K54_RS22665	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K54_RS22670	COG2009	succinate dehydrogenase
I6K54_RS22705	COG1984	allophanate hydrolase subunit 2
I6K54_RS22710	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K54_RS22725	COG0415	Belongs to the DNA photolyase family
I6K54_RS22755	COG2205	protein histidine kinase activity
I6K54_RS22760	COG0745	RESPONSE REGULATOR receiver
I6K54_RS22770	COG0033	Phosphoglucomutase
I6K54_RS22780	COG0596	Alpha beta hydrolase
I6K54_RS22795	COG0735	belongs to the Fur family
I6K54_RS22835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K54_RS22840	COG1846	Transcriptional regulator
I6K54_RS22840	COG1940	carbohydrate kinase activity
I6K54_RS22845	COG0647	UMP catabolic process
I6K54_RS22850	COG0367	asparagine synthase
I6K54_RS22890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K54_RS22900	COG1702	phosphate starvation-inducible protein PhoH
I6K54_RS22925	COG0765	amino acid transport
I6K54_RS22930	COG0765	amino acid transport
I6K54_RS22935	COG1126	abc transporter atp-binding protein
I6K54_RS22950	COG2888	peptidyl-tyrosine sulfation
I6K54_RS22965	COG1466	dna polymerase III delta subunit
I6K54_RS22980	COG0799	negative regulation of ribosome biogenesis
I6K54_RS22990	COG0768	penicillin binding
I6K54_RS22995	COG0772	Belongs to the SEDS family
I6K54_RS23000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K54_RS23005	COG1686	Belongs to the peptidase S11 family
I6K54_RS23020	COG0583	DNA-binding transcription factor activity
I6K54_RS23035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K54_RS23055	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K54_RS23060	COG3719	Belongs to the RNase T2 family
I6K54_RS23065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K54_RS23085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K54_RS23090	COG0583	DNA-binding transcription factor activity
I6K54_RS23095	COG3969	phosphoadenosine phosphosulfate
I6K54_RS23100	COG1475	DNA binding
I6K54_RS23105	COG0436	Aminotransferase
I6K54_RS23130	COG1129	ABC transporter
I6K54_RS23135	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS23140	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS23150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K54_RS23165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K54_RS23175	COG0402	S-adenosylhomocysteine deaminase activity
I6K54_RS23185	COG0483	inositol monophosphate 1-phosphatase activity
I6K54_RS23190	COG2271	Major facilitator Superfamily
I6K54_RS23220	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS23225	COG1129	ABC transporter
I6K54_RS23230	COG0371	Dehydrogenase
I6K54_RS23235	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS23250	COG2879	small protein
I6K54_RS23255	COG1966	Carbon starvation protein
I6K54_RS23265	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS23270	COG1535	isochorismatase
I6K54_RS23270	COG3433	isochorismatase activity
I6K54_RS23275	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K54_RS23280	COG1169	isochorismate synthase
I6K54_RS23285	COG4592	Periplasmic binding protein
I6K54_RS23295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS23300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS23305	COG1120	ATPase activity
I6K54_RS23310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K54_RS23310	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K54_RS23315	COG3251	PFAM MbtH domain protein
I6K54_RS23320	COG2382	esterase
I6K54_RS23325	COG4771	TonB-dependent receptor
I6K54_RS23330	COG2977	Belongs to the P-Pant transferase superfamily
I6K54_RS23335	COG3958	Transketolase
I6K54_RS23340	COG3959	Transketolase, thiamine diphosphate binding domain
I6K54_RS23345	COG2390	Transcriptional regulator
I6K54_RS23350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K54_RS23355	COG1879	ABC-type sugar transport system periplasmic component
I6K54_RS23365	COG1129	ABC transporter
I6K54_RS23370	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS23380	COG1028	Short-chain dehydrogenase reductase Sdr
I6K54_RS23390	COG0583	DNA-binding transcription factor activity
I6K54_RS23395	COG0668	transmembrane transport
I6K54_RS23405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K54_RS23430	COG0747	negative chemotaxis
I6K54_RS23435	COG0601	transmembrane transport
I6K54_RS23440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K54_RS23445	COG0444	Belongs to the ABC transporter superfamily
I6K54_RS23450	COG4608	Belongs to the ABC transporter superfamily
I6K54_RS23455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K54_RS23460	COG4221	oxidoreductase activity
I6K54_RS23470	COG4215	(ABC) transporter
I6K54_RS23475	COG0765	amino acid transport
I6K54_RS23480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K54_RS23495	COG0697	spore germination
I6K54_RS23510	COG4608	Belongs to the ABC transporter superfamily
I6K54_RS23515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K54_RS23525	COG4166	transmembrane transport
I6K54_RS23535	COG3698	Phosphodiester glycosidase
I6K54_RS23575	COG2315	Protein conserved in bacteria
I6K54_RS23580	COG0778	Nitroreductase
I6K54_RS23605	COG0477	Major facilitator Superfamily
I6K54_RS23610	COG0668	transmembrane transport
I6K54_RS23615	COG1609	Transcriptional regulator
I6K54_RS23625	COG0673	inositol 2-dehydrogenase activity
I6K54_RS23635	COG2211	Major facilitator Superfamily
I6K54_RS23640	COG1113	amino acid transport
I6K54_RS23655	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS23660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K54_RS23670	COG0531	amino acid
I6K54_RS23685	COG4680	protein conserved in bacteria
I6K54_RS23725	COG0667	Aldo Keto reductase
I6K54_RS23730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS23735	COG1473	amidohydrolase
I6K54_RS23765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS23770	COG1120	ATPase activity
I6K54_RS23775	COG1566	PFAM secretion protein HlyD family protein
I6K54_RS23820	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K54_RS23825	COG1129	ABC transporter
I6K54_RS23840	COG0673	inositol 2-dehydrogenase activity
I6K54_RS23870	COG3104	oligopeptide transport
I6K54_RS23875	COG1982	Orn Lys Arg decarboxylase major
I6K54_RS23880	COG0531	amino acid
I6K54_RS23885	COG3710	Transcriptional regulator
I6K54_RS23895	COG1560	Kdo2-lipid A biosynthetic process
I6K54_RS23910	COG3188	usher protein
I6K54_RS23915	COG3121	Chaperone
I6K54_RS23920	COG3539	Fimbrial protein
I6K54_RS23975	COG2501	S4 domain
I6K54_RS23985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K54_RS24000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K54_RS24005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K54_RS24025	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K54_RS24030	COG4181	ATPase activity
I6K54_RS24035	COG2755	lipolytic protein G-D-S-L family
I6K54_RS24040	COG0300	oxidoreductase activity
I6K54_RS24045	COG3118	belongs to the thioredoxin family
I6K54_RS24050	COG0390	transport system, permease component
I6K54_RS24055	COG4619	ABC transporter
I6K54_RS24060	COG0330	HflC and HflK could
I6K54_RS24065	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K54_RS24080	COG3735	TraB family
I6K54_RS24085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K54_RS24095	COG2223	nitrite transmembrane transporter activity
I6K54_RS24100	COG4651	solute:proton antiporter activity
I6K54_RS24100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K54_RS24105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K54_RS24145	COG2832	Protein of unknown function (DUF454)
I6K54_RS24150	COG3923	Primosomal replication protein n
I6K54_RS24160	COG5464	transposase or invertase
I6K54_RS24165	COG1196	nuclear chromosome segregation
I6K54_RS24165	COG3264	Mechanosensitive ion channel
I6K54_RS24170	COG1309	transcriptional regulator
I6K54_RS24175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS24180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K54_RS24195	COG0110	maltose O-acetyltransferase activity
I6K54_RS24250	COG1874	Beta-galactosidase
I6K54_RS24255	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K54_RS24260	COG3833	ABC-type maltose transport systems, permease component
I6K54_RS24265	COG1175	transmembrane transport
I6K54_RS24270	COG2182	Extracellular solute-binding protein
I6K54_RS24280	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K54_RS24295	COG2364	Membrane
I6K54_RS24325	COG3695	enzyme binding
I6K54_RS24330	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K54_RS24335	COG1946	Acyl-CoA thioesterase
I6K54_RS24340	COG0004	ammonium transporteR
I6K54_RS24345	COG0347	Belongs to the P(II) protein family
I6K54_RS24350	COG1132	(ABC) transporter
I6K54_RS24355	COG1132	(ABC) transporter
I6K54_RS24360	COG1522	sequence-specific DNA binding
I6K54_RS24375	COG4533	DNA binding
I6K54_RS24385	COG0824	Thioesterase
I6K54_RS24390	COG1555	photosystem II stabilization
I6K54_RS24395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K54_RS24400	COG0776	regulation of translation
I6K54_RS24405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K54_RS24425	COG0271	Belongs to the BolA IbaG family
I6K54_RS24430	COG3056	Lipoprotein
I6K54_RS24435	COG2223	nitrite transmembrane transporter activity
I6K54_RS24440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K54_RS24445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K54_RS24450	COG1845	cytochrome c oxidase, subunit III
I6K54_RS24455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K54_RS24470	COG1414	Transcriptional regulator
I6K54_RS24475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K54_RS24480	COG1053	succinate dehydrogenase
I6K54_RS24490	COG1053	succinate dehydrogenase
I6K54_RS24505	COG0673	inositol 2-dehydrogenase activity
I6K54_RS24510	COG2814	Major facilitator Superfamily
I6K54_RS24520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K54_RS24525	COG0693	protein deglycase activity
I6K54_RS24545	COG0142	geranyltranstransferase activity
I6K54_RS24555	COG0667	Aldo Keto reductase
I6K54_RS24560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K54_RS24580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K54_RS24580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K54_RS24590	COG4238	major outer membrane lipoprotein
I6K54_RS24610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K54_RS24615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K54_RS24620	COG1862	Preprotein translocase
I6K54_RS24645	COG0450	alkyl hydroperoxide reductase
I6K54_RS24655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS24670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K54_RS24680	COG1228	amidohydrolase
I6K54_RS24690	COG1335	isochorismatase
I6K54_RS24695	COG0583	DNA-binding transcription factor activity
I6K54_RS24700	COG0366	Alpha amylase catalytic
I6K54_RS24725	COG0420	3'-5' exonuclease activity
I6K54_RS24730	COG0419	ATPase involved in DNA repair
I6K54_RS24735	COG1940	carbohydrate kinase activity
I6K54_RS24750	COG4126	flavin adenine dinucleotide binding
I6K54_RS24760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K54_RS24765	COG3416	Protein conserved in bacteria
I6K54_RS24775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K54_RS24785	COG1785	Belongs to the alkaline phosphatase family
I6K54_RS24825	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K54_RS24830	COG1335	isochorismatase
I6K54_RS24835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K54_RS24840	COG0113	porphobilinogen synthase activity
I6K54_RS24850	COG2175	clavaminate synthase activity
I6K54_RS24855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K54_RS24860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K54_RS24865	COG4521	taurine ABC transporter
I6K54_RS24870	COG2040	homocysteine
I6K54_RS24875	COG0833	amino acid
I6K54_RS24890	COG4303	Ethanolamine ammonia lyase large subunit
I6K54_RS24895	COG4302	ethanolamine ammonia-lyase activity
I6K54_RS24935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K54_RS24940	COG1126	abc transporter atp-binding protein
I6K54_RS24945	COG4597	amino acid ABC transporter
I6K54_RS24950	COG0765	amino acid transport
I6K54_RS24965	COG3188	usher protein
I6K54_RS24990	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K54_RS25000	COG3639	organic phosphonate transmembrane transporter activity
I6K54_RS25020	COG0791	NLP P60 protein
I6K54_RS25045	COG0582	viral genome integration into host DNA
I6K54_RS25125	COG2909	trisaccharide binding
I6K54_RS25130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K54_RS25135	COG0022	dehydrogenase e1 component
I6K54_RS25140	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K54_RS25145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K54_RS25155	COG0625	glutathione transferase activity
I6K54_RS25160	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K54_RS25175	COG0579	oxidoreductase
I6K54_RS25180	COG1012	belongs to the aldehyde dehydrogenase family
I6K54_RS25185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K54_RS25190	COG1113	amino acid transport
I6K54_RS25195	COG1802	Transcriptional regulator
I6K54_RS25215	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K54_RS25220	COG0454	-acetyltransferase
I6K54_RS25235	COG2991	Protein conserved in bacteria
I6K54_RS25250	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K54_RS25255	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K54_RS25270	COG3034	peptidoglycan biosynthetic process
I6K54_RS25275	COG0121	glutamine amidotransferase
I6K54_RS25285	COG1960	acyl-CoA dehydrogenase activity
I6K54_RS25290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K54_RS25300	COG0583	DNA-binding transcription factor activity
I6K54_RS25310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K54_RS25320	COG2226	methyltransferase
I6K54_RS25330	COG1388	LysM domain
I6K54_RS25330	COG0741	lytic transglycosylase activity
I6K54_RS25335	COG2226	methyltransferase
I6K54_RS25345	COG2814	Major facilitator Superfamily
I6K54_RS25350	COG0583	DNA-binding transcription factor activity
I6K54_RS25355	COG0656	L-ascorbic acid biosynthetic process
I6K54_RS25390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K54_RS25400	COG2011	ABC-type metal ion transport system permease component
I6K54_RS25405	COG1464	Belongs to the NlpA lipoprotein family
I6K54_RS25415	COG1720	tRNA m6t6A37 methyltransferase activity
I6K54_RS25425	COG0791	NLP P60 protein
I6K54_RS25430	COG3015	lipoprotein NlpE involved in copper resistance
I6K54_RS25435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K54_RS25450	COG4568	rho-dependent transcription termination
I6K54_RS25460	COG0346	lactoylglutathione lyase activity
I6K54_RS25465	COG1982	Orn Lys Arg decarboxylase major
I6K54_RS25475	COG0587	DNA-directed DNA polymerase activity
I6K54_RS25505	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K54_RS25515	COG0750	zinc metalloprotease
I6K54_RS25520	COG0575	Belongs to the CDS family
I6K54_RS25530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K54_RS25555	COG0024	Methionine aminopeptidase
I6K54_RS25560	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K54_RS25575	COG3835	regulator
I6K54_RS25580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K54_RS25600	COG2860	membrane
I6K54_RS25620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K54_RS25625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K54_RS25630	COG1120	ATPase activity
I6K54_RS25635	COG4774	siderophore transport
I6K54_RS25640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K54_RS25735	COG1643	Atp-dependent helicase
I6K54_RS25740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K54_RS25760	COG0617	tRNA 3'-terminal CCA addition
I6K54_RS25765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K54_RS25785	COG0726	polysaccharide deacetylase
I6K54_RS25790	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K54_RS25795	COG0842	Transport permease protein
I6K54_RS25800	COG1131	(ABC) transporter
I6K54_RS25805	COG0288	reversible hydration of carbon dioxide
I6K54_RS25820	COG4993	Dehydrogenase
I6K54_RS25825	COG2132	Multicopper oxidase
I6K54_RS25870	COG3064	Membrane
I6K54_RS25885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K54_RS25890	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K54_RS25895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K54_RS25900	COG2186	Transcriptional regulator
I6K54_RS25920	COG2211	Major facilitator Superfamily
I6K54_RS25925	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K54_RS25930	COG3725	Membrane protein required for beta-lactamase induction
I6K54_RS25935	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K54_RS25945	COG4969	Belongs to the N-Me-Phe pilin family
I6K54_RS25950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K54_RS25955	COG1459	type II secretion system
I6K54_RS25980	COG0494	nUDIX hydrolase
I6K54_RS26000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K54_RS26005	COG0849	cell division
I6K54_RS26030	COG0772	Belongs to the SEDS family
I6K54_RS26045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K54_RS26050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K54_RS26055	COG0768	penicillin binding
I6K54_RS26075	COG1609	Transcriptional regulator
I6K54_RS26085	COG0028	Belongs to the TPP enzyme family
I6K54_RS26130	COG0738	Major facilitator superfamily
I6K54_RS26140	COG0583	DNA-binding transcription factor activity
I6K54_RS26145	COG2271	Major facilitator Superfamily
I6K54_RS26150	COG2814	Major facilitator Superfamily
I6K54_RS26170	COG1178	ABC-type Fe3 transport system permease component
I6K54_RS26180	COG0586	Pfam SNARE associated Golgi protein
I6K54_RS26200	COG0235	Class ii aldolase
I6K54_RS26205	COG0417	DNA replication proofreading
I6K54_RS26215	COG0564	pseudouridine synthase activity
I6K54_RS26225	COG3493	citrate carrier protein
I6K54_RS26240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K54_RS26245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K54_RS26255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K54_RS26300	COG0505	Belongs to the CarA family
I6K54_RS26380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K54_RS26410	COG5499	transcription regulator containing HTH domain
I6K54_RS26455	COG1528	Iron-storage protein
I6K54_RS26460	COG3039	Transposase
I6K54_RS26485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K54_RS26490	COG1127	ABC transporter
I6K54_RS26515	COG2801	Transposase and inactivated derivatives
I6K54_RS26525	COG2801	Transposase and inactivated derivatives
I6K54_RS26590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K54_RS26620	COG0431	NADPH-dependent FMN reductase
I6K54_RS26635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K54_RS26655	COG2205	protein histidine kinase activity
I6K54_RS26660	COG0745	RESPONSE REGULATOR receiver
I6K54_RS26665	COG1276	copper resistance
I6K54_RS26670	COG2372	response to copper ion
I6K54_RS26675	COG3667	copper resistance
I6K54_RS26680	COG2132	Multicopper oxidase
I6K54_RS26690	COG0739	heme binding
I6K54_RS26720	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K54_RS26765	COG1609	Transcriptional regulator
I6K54_RS26775	COG2223	nitrite transmembrane transporter activity
I6K54_RS26785	COG2197	response regulator
I6K54_RS26825	COG3436	PFAM IS66 Orf2 family protein
I6K54_RS26830	COG4372	Transposase
I6K54_RS26915	COG3344	reverse transcriptase
I6K54_RS27010	COG1475	DNA binding
I6K54_RS27035	COG2963	transposase activity
I6K54_RS27040	COG2801	Transposase and inactivated derivatives
I6K54_RS27045	COG3328	transposase activity
I6K54_RS27055	COG3547	Transposase (IS116 IS110 IS902 family)
I6K54_RS27060	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K54_RS27075	COG2814	Major facilitator Superfamily
I6K54_RS27120	COG3941	tape measure
I6K54_RS27210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K54_RS27215	COG1475	DNA binding
I6K54_RS27220	COG1475	DNA binding
I6K54_RS27325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6K54_RS27335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K54_RS27340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K54_RS27410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K54_RS27490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K54_RS27495	COG1702	phosphate starvation-inducible protein PhoH
I6K54_RS27580	COG3436	PFAM IS66 Orf2 family protein
I6K54_RS27585	COG4372	Transposase
I6K54_RS27750	COG3409	Peptidoglycan-binding domain 1 protein
I6K54_RS27750	COG3429	Glucose-6-phosphate dehydrogenase subunit
I6K54_RS27765	COG3436	PFAM IS66 Orf2 family protein
I6K54_RS27855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol