locus-tag	class	description
I6K55_RS00010	COG0747	negative chemotaxis
I6K55_RS00030	COG2223	nitrite transmembrane transporter activity
I6K55_RS00040	COG2133	pyrroloquinoline quinone binding
I6K55_RS00045	COG0625	glutathione transferase activity
I6K55_RS00055	COG1686	Belongs to the peptidase S11 family
I6K55_RS00060	COG1349	DNA-binding transcription factor activity
I6K55_RS00065	COG0671	phosphoesterase, PA-phosphatase related
I6K55_RS00070	COG2814	Major facilitator Superfamily
I6K55_RS00075	COG0561	phosphatase activity
I6K55_RS00080	COG0738	Major facilitator superfamily
I6K55_RS00085	COG3226	Transcriptional regulator
I6K55_RS00110	COG0778	Nitroreductase
I6K55_RS00125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K55_RS00130	COG3842	ATPase activity
I6K55_RS00135	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K55_RS00140	COG1177	transmembrane transport
I6K55_RS00155	COG0745	RESPONSE REGULATOR receiver
I6K55_RS00160	COG5002	protein histidine kinase activity
I6K55_RS00165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS00170	COG4160	amino acid transport
I6K55_RS00175	COG4215	(ABC) transporter
I6K55_RS00180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS00185	COG1126	abc transporter atp-binding protein
I6K55_RS00195	COG5001	Diguanylate cyclase
I6K55_RS00195	COG2203	Gaf domain
I6K55_RS00195	COG3706	GGDEF domain
I6K55_RS00195	COG4251	negative regulation of phosphorylation
I6K55_RS00200	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K55_RS00205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K55_RS00210	COG0702	epimerase
I6K55_RS00215	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K55_RS00220	COG0028	Belongs to the TPP enzyme family
I6K55_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K55_RS00240	COG2431	L-lysine efflux transmembrane transporter activity
I6K55_RS00250	COG3593	DNA synthesis involved in DNA repair
I6K55_RS00255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS00265	COG1278	Cold shock
I6K55_RS00275	COG0542	response to heat
I6K55_RS00290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K55_RS00295	COG4988	ABC transporter
I6K55_RS00300	COG0492	ferredoxin-NADP+ reductase activity
I6K55_RS00310	COG1674	ftsk spoiiie
I6K55_RS00310	COG1178	ABC-type Fe3 transport system permease component
I6K55_RS00320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K55_RS00330	COG0243	molybdopterin cofactor binding
I6K55_RS00335	COG0437	4 iron, 4 sulfur cluster binding
I6K55_RS00340	COG3302	dmso reductase anchor subunit
I6K55_RS00345	COG0477	Major facilitator Superfamily
I6K55_RS00350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K55_RS00355	COG1882	Formate acetyltransferase
I6K55_RS00360	COG2116	formate transmembrane transporter activity
I6K55_RS00365	COG1944	ATP diphosphatase activity
I6K55_RS00370	COG2323	membrane
I6K55_RS00390	COG0539	negative regulation of cytoplasmic translation
I6K55_RS00400	COG0658	competence protein
I6K55_RS00400	COG2333	competence protein COMEC
I6K55_RS00415	COG3214	Protein conserved in bacteria
I6K55_RS00430	COG3173	Aminoglycoside phosphotransferase
I6K55_RS00435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K55_RS00440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K55_RS00450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K55_RS00460	COG2989	Protein conserved in bacteria
I6K55_RS00465	COG3108	Peptidase M15
I6K55_RS00470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K55_RS00475	COG1448	Aminotransferase
I6K55_RS00480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K55_RS00500	COG0814	amino acid
I6K55_RS00510	COG1473	amidohydrolase
I6K55_RS00520	COG0308	aminopeptidase N
I6K55_RS00530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K55_RS00535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K55_RS00540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K55_RS00545	COG0431	NADPH-dependent FMN reductase
I6K55_RS00560	COG0633	Ferredoxin
I6K55_RS00560	COG3217	Mosc domain protein beta barrel domain protein
I6K55_RS00570	COG0488	(ABC) transporter
I6K55_RS00575	COG2995	paraquat-inducible protein a
I6K55_RS00580	COG3008	intermembrane lipid transfer
I6K55_RS00580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K55_RS00585	COG3009	Protein conserved in bacteria
I6K55_RS00590	COG3130	regulation of translation
I6K55_RS00600	COG1067	ATP-dependent peptidase activity
I6K55_RS00620	COG3070	regulator of competence-specific genes
I6K55_RS00625	COG1289	transmembrane transporter activity
I6K55_RS00630	COG3304	Inner membrane component domain
I6K55_RS00635	COG0210	DNA helicase
I6K55_RS00645	COG1832	CoA-binding protein
I6K55_RS00660	COG1881	PFAM PEBP family protein
I6K55_RS00665	COG2207	Transcriptional regulator
I6K55_RS00680	COG0670	Belongs to the BI1 family
I6K55_RS00705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K55_RS00710	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS00715	COG4638	Rieske (2fe-2S)
I6K55_RS00720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K55_RS00725	COG0473	3-isopropylmalate dehydrogenase activity
I6K55_RS00730	COG0583	DNA-binding transcription factor activity
I6K55_RS00735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K55_RS00740	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS00745	COG1396	sequence-specific DNA binding
I6K55_RS00745	COG1917	Cupin 2, conserved barrel domain protein
I6K55_RS00750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K55_RS00755	COG0174	glutamine synthetase
I6K55_RS00760	COG0531	amino acid
I6K55_RS00775	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS00805	COG3729	General stress protein
I6K55_RS00815	COG2233	PERMEase
I6K55_RS00850	COG1309	transcriptional regulator
I6K55_RS00865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K55_RS00875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K55_RS00895	COG1702	phosphate starvation-inducible protein PhoH
I6K55_RS00900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K55_RS00910	COG1335	isochorismatase
I6K55_RS00920	COG0583	DNA-binding transcription factor activity
I6K55_RS00925	COG1309	transcriptional regulator
I6K55_RS00955	COG3381	protein complex oligomerization
I6K55_RS00990	COG5645	(Lipo)protein
I6K55_RS01005	COG1560	Kdo2-lipid A biosynthetic process
I6K55_RS01050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K55_RS01070	COG2814	Major facilitator Superfamily
I6K55_RS01075	COG0583	DNA-binding transcription factor activity
I6K55_RS01080	COG1530	ribonuclease E activity
I6K55_RS01100	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K55_RS01120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K55_RS01135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K55_RS01140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K55_RS01145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K55_RS01155	COG0470	DNA polymerase III
I6K55_RS01160	COG0084	hydrolase, TatD family'
I6K55_RS01170	COG0537	adenosine 5'-monophosphoramidase activity
I6K55_RS01175	COG5633	Lipoprotein
I6K55_RS01200	COG1252	NADH dehydrogenase
I6K55_RS01205	COG3134	Outer membrane lipoprotein
I6K55_RS01220	COG1309	transcriptional regulator
I6K55_RS01235	COG1376	ErfK ybiS ycfS ynhG family protein
I6K55_RS01235	COG1388	LysM domain
I6K55_RS01240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K55_RS01250	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K55_RS01260	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K55_RS01270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K55_RS01280	COG2390	Transcriptional regulator
I6K55_RS01295	COG3395	kinase activity
I6K55_RS01310	COG0698	ribose 5-phosphate isomerase
I6K55_RS01315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K55_RS01320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K55_RS01325	COG0318	PFAM AMP-dependent synthetase and ligase
I6K55_RS01340	COG1177	transmembrane transport
I6K55_RS01360	COG2850	peptidyl-arginine hydroxylation
I6K55_RS01365	COG2205	protein histidine kinase activity
I6K55_RS01385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K55_RS01405	COG1187	pseudouridine synthase activity
I6K55_RS01410	COG0538	isocitrate dehydrogenase activity
I6K55_RS01415	COG0640	Transcriptional regulator
I6K55_RS01435	COG3813	Protein conserved in bacteria
I6K55_RS01440	COG1063	alcohol dehydrogenase
I6K55_RS01450	COG3729	General stress protein
I6K55_RS01455	COG3685	Protein conserved in bacteria
I6K55_RS01460	COG3685	Protein conserved in bacteria
I6K55_RS01470	COG1271	oxidase subunit
I6K55_RS01475	COG1294	oxidase, subunit
I6K55_RS01505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K55_RS01510	COG0583	DNA-binding transcription factor activity
I6K55_RS01515	COG3706	GGDEF domain
I6K55_RS01520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K55_RS01530	COG1560	Kdo2-lipid A biosynthetic process
I6K55_RS01540	COG3182	Iron-regulated membrane protein
I6K55_RS01560	COG2203	Gaf domain
I6K55_RS01560	COG2199	diguanylate cyclase activity
I6K55_RS01565	COG3042	response to heat
I6K55_RS01570	COG3189	MarR family transcriptional regulator
I6K55_RS01575	COG1683	Conserved Protein
I6K55_RS01580	COG0504	CTP synthase activity
I6K55_RS01585	COG2807	transmembrane transport
I6K55_RS01590	COG2207	Transcriptional regulator
I6K55_RS01600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K55_RS01605	COG0859	PFAM glycosyl transferase family 9
I6K55_RS01615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K55_RS01620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K55_RS01625	COG0583	DNA-binding transcription factor activity
I6K55_RS01630	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS01655	COG0386	Belongs to the glutathione peroxidase family
I6K55_RS01670	COG2766	serine protein kinase
I6K55_RS01675	COG3713	MltA-interacting MipA family protein
I6K55_RS01680	COG0656	L-ascorbic acid biosynthetic process
I6K55_RS01700	COG3139	Protein of unknown function (DUF1315)
I6K55_RS01715	COG1335	isochorismatase
I6K55_RS01720	COG0252	asparaginase activity
I6K55_RS01725	COG0616	signal peptide processing
I6K55_RS01730	COG0778	Nitroreductase
I6K55_RS01740	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K55_RS01745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K55_RS01750	COG0604	alcohol dehydrogenase
I6K55_RS01750	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS01750	COG3321	synthase
I6K55_RS01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K55_RS01760	COG0494	nUDIX hydrolase
I6K55_RS01765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K55_RS01770	COG2897	thiosulfate sulfurtransferase activity
I6K55_RS01775	COG4136	ATPase activity
I6K55_RS01780	COG4135	transport system, permease component
I6K55_RS01785	COG4134	Bacterial extracellular solute-binding protein
I6K55_RS01790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K55_RS01795	COG0398	Pfam SNARE associated Golgi protein
I6K55_RS01800	COG0398	Pfam SNARE associated Golgi protein
I6K55_RS01805	COG0708	Exodeoxyribonuclease III
I6K55_RS01815	COG3138	arginine N-succinyltransferase
I6K55_RS01825	COG3724	N-succinylarginine dihydrolase activity
I6K55_RS01835	COG3678	ATP-independent chaperone mediated protein folding
I6K55_RS01840	COG0322	excinuclease ABC activity
I6K55_RS01850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K55_RS01855	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS01865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS01870	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K55_RS01875	COG1917	Cupin 2, conserved barrel domain protein
I6K55_RS01875	COG2169	Transcriptional regulator
I6K55_RS01880	COG1486	melibiose metabolic process
I6K55_RS01890	COG0753	catalase activity
I6K55_RS01900	COG1823	symporter activity
I6K55_RS01905	COG1988	membrane-bound metal-dependent
I6K55_RS01910	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS01915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K55_RS01945	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K55_RS01950	COG3047	cAMP biosynthetic process
I6K55_RS01960	COG4774	siderophore transport
I6K55_RS01995	COG0135	phosphoribosylanthranilate isomerase activity
I6K55_RS01995	COG0134	indole-3-glycerol-phosphate synthase activity
I6K55_RS02000	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K55_RS02000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K55_RS02005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K55_RS02015	COG0009	L-threonylcarbamoyladenylate synthase
I6K55_RS02025	COG0583	DNA-binding transcription factor activity
I6K55_RS02035	COG0653	protein targeting
I6K55_RS02055	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K55_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS02070	COG0616	signal peptide processing
I6K55_RS02095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K55_RS02105	COG0671	phosphoesterase, PA-phosphatase related
I6K55_RS02110	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K55_RS02115	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K55_RS02125	COG0023	Translation Initiation Factor
I6K55_RS02135	COG1349	DNA-binding transcription factor activity
I6K55_RS02150	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K55_RS02150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K55_RS02155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K55_RS02165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K55_RS02180	COG4171	peptide transport system, permease
I6K55_RS02200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K55_RS02255	COG1484	DNA-dependent DNA replication
I6K55_RS02315	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K55_RS02320	COG0484	heat shock protein binding
I6K55_RS02460	COG1196	nuclear chromosome segregation
I6K55_RS02460	COG1196	nuclear chromosome segregation
I6K55_RS02500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K55_RS02505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K55_RS02510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K55_RS02520	COG2135	peptidase activity
I6K55_RS02535	COG0702	epimerase
I6K55_RS02550	COG1473	amidohydrolase
I6K55_RS02560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K55_RS02565	COG1842	Phage shock protein A
I6K55_RS02575	COG1983	PspC domain protein
I6K55_RS02585	COG3106	COG3106 Predicted ATPase
I6K55_RS02595	COG0583	DNA-binding transcription factor activity
I6K55_RS02600	COG1486	melibiose metabolic process
I6K55_RS02610	COG3180	Ammonia monooxygenase
I6K55_RS02615	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K55_RS02620	COG4948	Mandelate Racemase Muconate Lactonizing
I6K55_RS02625	COG2866	Carboxypeptidase
I6K55_RS02635	COG4166	transmembrane transport
I6K55_RS02665	COG0656	L-ascorbic acid biosynthetic process
I6K55_RS02685	COG0583	DNA-binding transcription factor activity
I6K55_RS02690	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS02695	COG1078	dGTPase activity
I6K55_RS02700	COG0693	protein deglycase activity
I6K55_RS02725	COG2885	chlorophyll binding
I6K55_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS02815	COG1309	transcriptional regulator
I6K55_RS02820	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS02840	COG0583	DNA-binding transcription factor activity
I6K55_RS02870	COG0604	alcohol dehydrogenase
I6K55_RS02875	COG0436	Aminotransferase
I6K55_RS02890	COG2011	ABC-type metal ion transport system permease component
I6K55_RS02895	COG1448	Aminotransferase
I6K55_RS02905	COG1522	sequence-specific DNA binding
I6K55_RS02910	COG1113	amino acid transport
I6K55_RS02925	COG0673	inositol 2-dehydrogenase activity
I6K55_RS02930	COG1349	DNA-binding transcription factor activity
I6K55_RS02940	COG0513	Belongs to the DEAD box helicase family
I6K55_RS02950	COG0589	response to stress
I6K55_RS02960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K55_RS02965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K55_RS02965	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K55_RS02965	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K55_RS02965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K55_RS02970	COG3042	response to heat
I6K55_RS02975	COG3187	Heat shock protein
I6K55_RS02980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K55_RS02985	COG0586	Pfam SNARE associated Golgi protein
I6K55_RS02990	COG2911	Protein conserved in bacteria
I6K55_RS03000	COG3784	Protein of unknown function (DUF1318)
I6K55_RS03005	COG2207	Transcriptional regulator
I6K55_RS03010	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS03025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS03035	COG1126	abc transporter atp-binding protein
I6K55_RS03040	COG0583	DNA-binding transcription factor activity
I6K55_RS03045	COG2072	flavoprotein involved in K transport
I6K55_RS03060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K55_RS03080	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS03080	COG2030	dehydratase
I6K55_RS03085	COG3396	Phenylacetate-CoA oxygenase
I6K55_RS03090	COG3460	Phenylacetate-CoA oxygenase
I6K55_RS03095	COG3396	Phenylacetate-CoA oxygenase
I6K55_RS03100	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K55_RS03105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K55_RS03110	COG1024	Enoyl-CoA hydratase
I6K55_RS03115	COG1024	Enoyl-CoA hydratase
I6K55_RS03120	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K55_RS03125	COG2050	protein possibly involved in aromatic compounds catabolism
I6K55_RS03130	COG0183	Belongs to the thiolase family
I6K55_RS03135	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K55_RS03140	COG3327	negative regulation of DNA-templated transcription, initiation
I6K55_RS03145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K55_RS03160	COG1643	Atp-dependent helicase
I6K55_RS03165	COG4122	O-methyltransferase activity
I6K55_RS03190	COG0583	DNA-binding transcription factor activity
I6K55_RS03195	COG0667	Aldo Keto reductase
I6K55_RS03200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K55_RS03210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K55_RS03215	COG3138	arginine N-succinyltransferase
I6K55_RS03220	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS03225	COG3724	N-succinylarginine dihydrolase activity
I6K55_RS03230	COG2988	succinylglutamate desuccinylase activity
I6K55_RS03235	COG1113	amino acid transport
I6K55_RS03240	COG0477	Major facilitator Superfamily
I6K55_RS03245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K55_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS03260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K55_RS03265	COG0401	homolog of Blt101
I6K55_RS03270	COG5562	phage envelope protein
I6K55_RS03275	COG0425	Belongs to the sulfur carrier protein TusA family
I6K55_RS03280	COG2391	methyltransferase activity
I6K55_RS03305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K55_RS03310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS03310	COG1263	PTS System
I6K55_RS03315	COG1609	Transcriptional regulator
I6K55_RS03320	COG5339	Protein conserved in bacteria
I6K55_RS03325	COG1482	cell wall glycoprotein biosynthetic process
I6K55_RS03330	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K55_RS03330	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K55_RS03340	COG0114	fumarate hydratase activity
I6K55_RS03350	COG2205	protein histidine kinase activity
I6K55_RS03360	COG0745	RESPONSE REGULATOR receiver
I6K55_RS03365	COG3136	membrane protein required for alginate biosynthesis
I6K55_RS03375	COG0531	amino acid
I6K55_RS03390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K55_RS03395	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K55_RS03410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K55_RS03425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K55_RS03430	COG1473	amidohydrolase
I6K55_RS03440	COG0583	DNA-binding transcription factor activity
I6K55_RS03445	COG2840	Smr protein MutS2
I6K55_RS03450	COG1414	Transcriptional regulator
I6K55_RS03460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K55_RS03465	COG0183	Belongs to the thiolase family
I6K55_RS03475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K55_RS03480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K55_RS03490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K55_RS03490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K55_RS03510	COG4565	transcriptional regulatory protein
I6K55_RS03515	COG3290	protein histidine kinase activity
I6K55_RS03550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K55_RS03560	COG0679	Auxin Efflux Carrier
I6K55_RS03590	COG0628	permease
I6K55_RS03610	COG3591	Belongs to the peptidase S1B family
I6K55_RS03620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K55_RS03625	COG2814	Major facilitator Superfamily
I6K55_RS03630	COG0583	DNA-binding transcription factor activity
I6K55_RS03635	COG1940	carbohydrate kinase activity
I6K55_RS03640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K55_RS03655	COG3302	dmso reductase anchor subunit
I6K55_RS03660	COG0437	4 iron, 4 sulfur cluster binding
I6K55_RS03665	COG0243	molybdopterin cofactor binding
I6K55_RS03680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K55_RS03695	COG2271	Major facilitator Superfamily
I6K55_RS03700	COG0246	Mannitol dehydrogenase
I6K55_RS03705	COG0589	response to stress
I6K55_RS03710	COG1802	Transcriptional regulator
I6K55_RS03715	COG4221	oxidoreductase activity
I6K55_RS03730	COG2207	Transcriptional regulator
I6K55_RS03735	COG2135	peptidase activity
I6K55_RS03750	COG2197	response regulator
I6K55_RS03765	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K55_RS03770	COG1546	Belongs to the CinA family
I6K55_RS03775	COG2200	EAL domain
I6K55_RS03790	COG3708	Transcriptional regulator
I6K55_RS03790	COG2207	Transcriptional regulator
I6K55_RS03795	COG2610	gluconate transmembrane transporter activity
I6K55_RS03800	COG3622	Belongs to the hyi family
I6K55_RS03805	COG0235	Class ii aldolase
I6K55_RS03810	COG3395	kinase activity
I6K55_RS03815	COG2084	Dehydrogenase
I6K55_RS03820	COG1349	DNA-binding transcription factor activity
I6K55_RS03835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K55_RS03840	COG2223	nitrite transmembrane transporter activity
I6K55_RS03880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K55_RS03915	COG2814	Major facilitator Superfamily
I6K55_RS03930	COG4977	sequence-specific DNA binding
I6K55_RS03955	COG2271	Major facilitator Superfamily
I6K55_RS03960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K55_RS03965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K55_RS03975	COG3395	kinase activity
I6K55_RS03980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K55_RS03985	COG1349	DNA-binding transcription factor activity
I6K55_RS03990	COG0039	L-malate dehydrogenase activity
I6K55_RS04000	COG0583	DNA-binding transcription factor activity
I6K55_RS04005	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS04020	COG2199	diguanylate cyclase activity
I6K55_RS04085	COG0477	Major facilitator Superfamily
I6K55_RS04095	COG2070	2-Nitropropane dioxygenase
I6K55_RS04100	COG2011	ABC-type metal ion transport system permease component
I6K55_RS04120	COG4628	conserved protein (DUF2132)
I6K55_RS04135	COG2207	Transcriptional regulator
I6K55_RS04165	COG2233	PERMEase
I6K55_RS04170	COG3195	allantoin biosynthetic process
I6K55_RS04170	COG3648	Uricase
I6K55_RS04175	COG2351	hydroxyisourate hydrolase activity
I6K55_RS04180	COG1396	sequence-specific DNA binding
I6K55_RS04185	COG3550	peptidyl-serine autophosphorylation
I6K55_RS04190	COG1649	PFAM Uncharacterised BCR, COG1649
I6K55_RS04200	COG3188	usher protein
I6K55_RS04235	COG3300	MHYT domain
I6K55_RS04235	COG5001	Diguanylate cyclase
I6K55_RS04240	COG2819	hydrolase of the alpha beta superfamily
I6K55_RS04255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS04255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS04260	COG2814	Major facilitator Superfamily
I6K55_RS04270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS04270	COG1263	PTS System
I6K55_RS04275	COG2186	Transcriptional regulator
I6K55_RS04295	COG3835	regulator
I6K55_RS04300	COG1929	Belongs to the glycerate kinase type-1 family
I6K55_RS04345	COG0738	Major facilitator superfamily
I6K55_RS04350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K55_RS04355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K55_RS04360	COG1349	DNA-binding transcription factor activity
I6K55_RS04375	COG1349	DNA-binding transcription factor activity
I6K55_RS04380	COG4977	sequence-specific DNA binding
I6K55_RS04400	COG4977	sequence-specific DNA binding
I6K55_RS04425	COG0667	Aldo Keto reductase
I6K55_RS04430	COG3386	PFAM SMP-30 Gluconolaconase
I6K55_RS04435	COG0667	Aldo Keto reductase
I6K55_RS04440	COG0667	Aldo Keto reductase
I6K55_RS04450	COG0456	acetyltransferase
I6K55_RS04450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K55_RS04475	COG1652	LysM domain
I6K55_RS04485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K55_RS04485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K55_RS04485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K55_RS04490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K55_RS04500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K55_RS04505	COG3037	sugar-specific permease SgaT UlaA
I6K55_RS04515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS04520	COG1609	Transcriptional regulator
I6K55_RS04530	COG2223	nitrite transmembrane transporter activity
I6K55_RS04575	COG0477	Major facilitator Superfamily
I6K55_RS04580	COG4529	Protein conserved in bacteria
I6K55_RS04585	COG1902	pentaerythritol trinitrate reductase activity
I6K55_RS04595	COG0583	DNA-binding transcription factor activity
I6K55_RS04600	COG2070	2-Nitropropane dioxygenase
I6K55_RS04610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K55_RS04620	COG0765	amino acid transport
I6K55_RS04665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K55_RS04690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K55_RS04705	COG2207	Transcriptional regulator
I6K55_RS04720	COG1335	isochorismatase
I6K55_RS04725	COG0406	alpha-ribazole phosphatase activity
I6K55_RS04765	COG1953	Uracil, thiamine, allantoin
I6K55_RS04770	COG0402	S-adenosylhomocysteine deaminase activity
I6K55_RS04775	COG3706	GGDEF domain
I6K55_RS04790	COG0673	inositol 2-dehydrogenase activity
I6K55_RS04805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K55_RS04810	COG1116	anion transmembrane transporter activity
I6K55_RS04815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K55_RS04820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K55_RS04825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K55_RS04830	COG0076	glutamate decarboxylase activity
I6K55_RS04845	COG2205	protein histidine kinase activity
I6K55_RS04855	COG0596	Alpha beta hydrolase
I6K55_RS04895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K55_RS04895	COG0519	Catalyzes the synthesis of GMP from XMP
I6K55_RS04915	COG0583	DNA-binding transcription factor activity
I6K55_RS04925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K55_RS04930	COG1285	pathogenesis
I6K55_RS04935	COG2814	Major facilitator Superfamily
I6K55_RS04940	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K55_RS04945	COG0583	DNA-binding transcription factor activity
I6K55_RS04950	COG0243	molybdopterin cofactor binding
I6K55_RS04955	COG3781	membrane
I6K55_RS04980	COG1764	response to oxidative stress
I6K55_RS04990	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K55_RS05000	COG2323	membrane
I6K55_RS05010	COG0366	Alpha amylase catalytic
I6K55_RS05020	COG3685	Protein conserved in bacteria
I6K55_RS05030	COG3729	General stress protein
I6K55_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS05080	COG0488	(ABC) transporter
I6K55_RS05095	COG1064	alcohol dehydrogenase
I6K55_RS05100	COG0747	negative chemotaxis
I6K55_RS05110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K55_RS05120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K55_RS05130	COG2814	Major facilitator Superfamily
I6K55_RS05140	COG2326	polyphosphate kinase activity
I6K55_RS05155	COG2864	formate dehydrogenase
I6K55_RS05160	COG0437	4 iron, 4 sulfur cluster binding
I6K55_RS05195	COG3485	protocatechuate 3,4-dioxygenase
I6K55_RS05200	COG4829	muconolactone delta-isomerase
I6K55_RS05205	COG4948	Mandelate Racemase Muconate Lactonizing
I6K55_RS05210	COG1414	Transcriptional regulator
I6K55_RS05230	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K55_RS05235	COG1140	nitrate reductase beta subunit
I6K55_RS05240	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K55_RS05245	COG2181	nitrate reductase activity
I6K55_RS05250	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K55_RS05255	COG1178	ABC-type Fe3 transport system permease component
I6K55_RS05260	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K55_RS05265	COG3842	ATPase activity
I6K55_RS05270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K55_RS05285	COG2211	Major facilitator Superfamily
I6K55_RS05305	COG0625	glutathione transferase activity
I6K55_RS05315	COG1126	abc transporter atp-binding protein
I6K55_RS05320	COG0765	amino acid transport
I6K55_RS05330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS05335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K55_RS05340	COG1473	amidohydrolase
I6K55_RS05345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K55_RS05350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K55_RS05375	COG4772	TonB-dependent receptor
I6K55_RS05380	COG1228	amidohydrolase
I6K55_RS05385	COG3691	Protein conserved in bacteria
I6K55_RS05400	COG2130	NADP-dependent
I6K55_RS05410	COG1247	-acetyltransferase
I6K55_RS05415	COG3238	Protein conserved in bacteria
I6K55_RS05425	COG0747	negative chemotaxis
I6K55_RS05430	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS05465	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS05470	COG1177	transmembrane transport
I6K55_RS05475	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K55_RS05480	COG3842	ATPase activity
I6K55_RS05485	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K55_RS05490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K55_RS05495	COG1271	oxidase subunit
I6K55_RS05500	COG1294	oxidase, subunit
I6K55_RS05520	COG0826	peptidase U32
I6K55_RS05530	COG1396	sequence-specific DNA binding
I6K55_RS05535	COG3135	benzoate transporter
I6K55_RS05540	COG2207	Transcriptional regulator
I6K55_RS05540	COG3708	Transcriptional regulator
I6K55_RS05545	COG0697	spore germination
I6K55_RS05555	COG0500	methyltransferase
I6K55_RS05560	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K55_RS05565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K55_RS05570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K55_RS05585	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K55_RS05590	COG5383	Protein conserved in bacteria
I6K55_RS05595	COG3485	protocatechuate 3,4-dioxygenase
I6K55_RS05600	COG3485	protocatechuate 3,4-dioxygenase
I6K55_RS05605	COG0583	DNA-binding transcription factor activity
I6K55_RS05625	COG3038	cytochrome b561
I6K55_RS05645	COG2814	Major facilitator Superfamily
I6K55_RS05655	COG0673	inositol 2-dehydrogenase activity
I6K55_RS05665	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS05700	COG4659	FMN binding
I6K55_RS05710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K55_RS05720	COG0625	glutathione transferase activity
I6K55_RS05725	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K55_RS05740	COG3895	Periplasmic Protein
I6K55_RS05755	COG3706	GGDEF domain
I6K55_RS05770	COG1566	PFAM secretion protein HlyD family protein
I6K55_RS05775	COG1289	transmembrane transporter activity
I6K55_RS05780	COG2032	superoxide dismutase activity
I6K55_RS05785	COG4989	oxidoreductase activity
I6K55_RS05790	COG3313	Fe-S protein
I6K55_RS05795	COG1309	transcriptional regulator
I6K55_RS05800	COG1902	pentaerythritol trinitrate reductase activity
I6K55_RS05805	COG0346	lactoylglutathione lyase activity
I6K55_RS05815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K55_RS05820	COG0791	NLP P60 protein
I6K55_RS05835	COG2814	Major facilitator Superfamily
I6K55_RS05850	COG0583	DNA-binding transcription factor activity
I6K55_RS05855	COG2814	Major facilitator Superfamily
I6K55_RS05860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K55_RS05865	COG0307	riboflavin synthase, alpha
I6K55_RS05920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K55_RS05955	COG1349	DNA-binding transcription factor activity
I6K55_RS05960	COG0346	lactoylglutathione lyase activity
I6K55_RS05985	COG0444	Belongs to the ABC transporter superfamily
I6K55_RS05990	COG4608	Belongs to the ABC transporter superfamily
I6K55_RS06020	COG3321	synthase
I6K55_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS06020	COG0604	alcohol dehydrogenase
I6K55_RS06070	COG0402	S-adenosylhomocysteine deaminase activity
I6K55_RS06095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K55_RS06100	COG0277	FAD linked oxidase domain protein
I6K55_RS06115	COG2814	Major facilitator Superfamily
I6K55_RS06145	COG0583	DNA-binding transcription factor activity
I6K55_RS06155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K55_RS06165	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K55_RS06170	COG2610	gluconate transmembrane transporter activity
I6K55_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS06205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K55_RS06220	COG0745	RESPONSE REGULATOR receiver
I6K55_RS06225	COG5002	protein histidine kinase activity
I6K55_RS06225	COG3850	Histidine kinase
I6K55_RS06240	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K55_RS06260	COG3088	subunit of a heme lyase
I6K55_RS06260	COG4235	cytochrome complex assembly
I6K55_RS06265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K55_RS06270	COG1138	Cytochrome C-type biogenesis protein
I6K55_RS06285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K55_RS06290	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K55_RS06295	COG4133	protoheme IX ABC transporter activity
I6K55_RS06325	COG1175	transmembrane transport
I6K55_RS06335	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K55_RS06340	COG3383	formate dehydrogenase (NAD+) activity
I6K55_RS06380	COG1126	abc transporter atp-binding protein
I6K55_RS06385	COG0765	amino acid transport
I6K55_RS06405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS06410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS06415	COG1120	ATPase activity
I6K55_RS06420	COG4774	siderophore transport
I6K55_RS06425	COG1116	anion transmembrane transporter activity
I6K55_RS06430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K55_RS06450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K55_RS06455	COG0583	DNA-binding transcription factor activity
I6K55_RS06475	COG2814	Major facilitator Superfamily
I6K55_RS06510	COG1414	Transcriptional regulator
I6K55_RS06515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K55_RS06520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS06525	COG1120	ATPase activity
I6K55_RS06535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K55_RS06540	COG2271	Major facilitator Superfamily
I6K55_RS06545	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K55_RS06545	COG1082	Xylose isomerase domain protein TIM barrel
I6K55_RS06550	COG1309	transcriptional regulator
I6K55_RS06580	COG1376	ErfK ybiS ycfS ynhG family protein
I6K55_RS06595	COG0719	Fe-S assembly protein
I6K55_RS06600	COG0396	ATPase activity
I6K55_RS06615	COG4256	Hemin uptake protein
I6K55_RS06625	COG0791	NLP P60 protein
I6K55_RS06635	COG0386	Belongs to the glutathione peroxidase family
I6K55_RS06655	COG0583	DNA-binding transcription factor activity
I6K55_RS06675	COG0072	phenylalanine-tRNA ligase activity
I6K55_RS06675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K55_RS06715	COG3137	Salt-induced outer membrane protein
I6K55_RS06720	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K55_RS06730	COG3001	Fructosamine kinase
I6K55_RS06740	COG2350	Protein conserved in bacteria
I6K55_RS06750	COG2353	YceI-like domain
I6K55_RS06770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K55_RS06780	COG0444	Belongs to the ABC transporter superfamily
I6K55_RS06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K55_RS06790	COG0601	transmembrane transport
I6K55_RS06795	COG4166	transmembrane transport
I6K55_RS06800	COG2095	MarC family integral membrane protein
I6K55_RS06810	COG1454	alcohol dehydrogenase
I6K55_RS06810	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS06815	COG1435	thymidine kinase activity
I6K55_RS06825	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K55_RS06830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K55_RS06835	COG0745	RESPONSE REGULATOR receiver
I6K55_RS06840	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K55_RS06850	COG0788	formyltetrahydrofolate deformylase activity
I6K55_RS06880	COG1522	sequence-specific DNA binding
I6K55_RS06890	COG2181	nitrate reductase activity
I6K55_RS06895	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K55_RS06900	COG1140	nitrate reductase beta subunit
I6K55_RS06905	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K55_RS06915	COG2223	nitrite transmembrane transporter activity
I6K55_RS06920	COG3850	Histidine kinase
I6K55_RS06925	COG2197	response regulator
I6K55_RS06930	COG4932	domain protein
I6K55_RS06935	COG0243	molybdopterin cofactor binding
I6K55_RS06940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K55_RS06940	COG2146	nitrite reductase [NAD(P)H] activity
I6K55_RS06945	COG1116	anion transmembrane transporter activity
I6K55_RS06955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K55_RS06960	COG3707	response regulator
I6K55_RS06965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K55_RS06975	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K55_RS06980	COG4572	Cation transport regulator
I6K55_RS06985	COG0387	Pfam Sodium calcium exchanger
I6K55_RS07005	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K55_RS07035	COG0659	secondary active sulfate transmembrane transporter activity
I6K55_RS07055	COG0012	GTP binding
I6K55_RS07145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K55_RS07210	COG2885	chlorophyll binding
I6K55_RS07230	COG3122	Protein conserved in bacteria
I6K55_RS07245	COG0583	DNA-binding transcription factor activity
I6K55_RS07275	COG0583	DNA-binding transcription factor activity
I6K55_RS07310	COG1882	Formate acetyltransferase
I6K55_RS07325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K55_RS07330	COG0583	DNA-binding transcription factor activity
I6K55_RS07370	COG2308	Evidence 4 Homologs of previously reported genes of
I6K55_RS07385	COG4774	siderophore transport
I6K55_RS07395	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K55_RS07420	COG2719	SpoVR family
I6K55_RS07450	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K55_RS07465	COG2894	cell division
I6K55_RS07475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K55_RS07485	COG3065	identical protein binding
I6K55_RS07495	COG1199	ATP-dependent helicase activity
I6K55_RS07500	COG0251	oxidation-reduction process
I6K55_RS07520	COG1760	l-serine dehydratase
I6K55_RS07525	COG2200	EAL domain
I6K55_RS07530	COG1253	flavin adenine dinucleotide binding
I6K55_RS07535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS07535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS07540	COG3715	PTS system
I6K55_RS07545	COG3716	PTS system mannose fructose sorbose family IID component
I6K55_RS07560	COG2226	methyltransferase
I6K55_RS07565	COG0768	penicillin binding
I6K55_RS07595	COG1414	Transcriptional regulator
I6K55_RS07600	COG2814	Major facilitator Superfamily
I6K55_RS07620	COG1956	GAF domain-containing protein
I6K55_RS07625	COG2995	paraquat-inducible protein a
I6K55_RS07630	COG3008	intermembrane lipid transfer
I6K55_RS07655	COG2990	Protein conserved in bacteria
I6K55_RS07670	COG1276	copper resistance
I6K55_RS07675	COG2372	response to copper ion
I6K55_RS07685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K55_RS07690	COG1770	oligopeptidase
I6K55_RS07695	COG2979	Protein of unknown function (DUF533)
I6K55_RS07700	COG3141	response to X-ray
I6K55_RS07710	COG0800	Aldolase
I6K55_RS07715	COG0129	dihydroxy-acid dehydratase activity
I6K55_RS07720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K55_RS07730	COG1737	Transcriptional regulator
I6K55_RS07740	COG1560	Kdo2-lipid A biosynthetic process
I6K55_RS07745	COG0739	heme binding
I6K55_RS07750	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K55_RS07760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K55_RS07785	COG0494	nUDIX hydrolase
I6K55_RS07795	COG1335	isochorismatase
I6K55_RS07800	COG1801	Protein of unknown function DUF72
I6K55_RS07805	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K55_RS07825	COG3102	Protein conserved in bacteria
I6K55_RS07835	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K55_RS07860	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS07870	COG1879	ABC-type sugar transport system periplasmic component
I6K55_RS07880	COG1528	Iron-storage protein
I6K55_RS07890	COG2211	Major facilitator Superfamily
I6K55_RS07900	COG0477	Major facilitator Superfamily
I6K55_RS07915	COG1528	Iron-storage protein
I6K55_RS07925	COG0814	amino acid
I6K55_RS07930	COG3318	Belongs to the UPF0149 family
I6K55_RS07930	COG3012	SEC-C Motif Domain Protein
I6K55_RS07965	COG2197	response regulator
I6K55_RS07975	COG2197	response regulator
I6K55_RS07980	COG1126	abc transporter atp-binding protein
I6K55_RS07985	COG0765	amino acid transport
I6K55_RS07995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS08000	COG0366	Alpha amylase catalytic
I6K55_RS08030	COG2354	Protein conserved in bacteria
I6K55_RS08035	COG0697	spore germination
I6K55_RS08040	COG3727	T/G mismatch-specific endonuclease activity
I6K55_RS08045	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K55_RS08050	COG1418	mRNA catabolic process
I6K55_RS08060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K55_RS08115	COG4584	PFAM Integrase catalytic
I6K55_RS08120	COG1484	DNA-dependent DNA replication
I6K55_RS08175	COG0740	serine-type endopeptidase activity
I6K55_RS08180	COG4695	Portal protein
I6K55_RS08185	COG1802	Transcriptional regulator
I6K55_RS08185	COG4626	Terminase
I6K55_RS08220	COG3772	lysozyme
I6K55_RS08240	COG1403	HNH endonuclease
I6K55_RS08245	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K55_RS08355	COG0025	NhaP-type Na H and K H
I6K55_RS08360	COG1309	transcriptional regulator
I6K55_RS08365	COG0604	alcohol dehydrogenase
I6K55_RS08385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K55_RS08395	COG0534	Mate efflux family protein
I6K55_RS08415	COG3706	GGDEF domain
I6K55_RS08440	COG3615	Tellurite resistance protein tehB
I6K55_RS08450	COG3300	MHYT domain
I6K55_RS08450	COG5001	Diguanylate cyclase
I6K55_RS08460	COG0477	Major facilitator Superfamily
I6K55_RS08465	COG0095	Lipoate-protein ligase
I6K55_RS08470	COG0583	DNA-binding transcription factor activity
I6K55_RS08475	COG1942	4-Oxalocrotonate Tautomerase
I6K55_RS08485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K55_RS08505	COG1289	transmembrane transporter activity
I6K55_RS08520	COG2925	Exonuclease
I6K55_RS08525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K55_RS08530	COG0640	Transcriptional regulator
I6K55_RS08535	COG0531	amino acid
I6K55_RS08545	COG0583	DNA-binding transcription factor activity
I6K55_RS08550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K55_RS08580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K55_RS08600	COG1215	transferase activity, transferring glycosyl groups
I6K55_RS08685	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K55_RS08765	COG0438	transferase activity, transferring glycosyl groups
I6K55_RS08775	COG1216	Glycosyl transferase, family 2
I6K55_RS08775	COG1442	glycosyl transferase family 8
I6K55_RS08830	COG1253	flavin adenine dinucleotide binding
I6K55_RS08835	COG2982	Protein involved in outer membrane biogenesis
I6K55_RS08850	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K55_RS08855	COG0443	Heat shock 70 kDa protein
I6K55_RS08860	COG5002	protein histidine kinase activity
I6K55_RS08880	COG1301	dicarboxylic acid transport
I6K55_RS08905	COG2205	protein histidine kinase activity
I6K55_RS08910	COG0745	RESPONSE REGULATOR receiver
I6K55_RS08915	COG0826	peptidase U32
I6K55_RS08925	COG4608	Belongs to the ABC transporter superfamily
I6K55_RS08930	COG0444	Belongs to the ABC transporter superfamily
I6K55_RS08935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K55_RS08940	COG0601	transmembrane transport
I6K55_RS08945	COG0747	negative chemotaxis
I6K55_RS08950	COG4948	Mandelate Racemase Muconate Lactonizing
I6K55_RS08955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K55_RS08965	COG1070	Carbohydrate kinase
I6K55_RS09000	COG1830	Aldolase
I6K55_RS09005	COG0351	phosphomethylpyrimidine kinase
I6K55_RS09020	COG0583	DNA-binding transcription factor activity
I6K55_RS09030	COG2252	PERMEase
I6K55_RS09035	COG0583	DNA-binding transcription factor activity
I6K55_RS09040	COG5455	response to cobalt ion
I6K55_RS09060	COG4807	Protein conserved in bacteria
I6K55_RS09070	COG3275	phosphorelay sensor kinase activity
I6K55_RS09080	COG1174	glycine betaine transport
I6K55_RS09085	COG1125	glycine betaine transport
I6K55_RS09090	COG1174	glycine betaine transport
I6K55_RS09095	COG1732	Glycine betaine
I6K55_RS09100	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K55_RS09105	COG0277	FAD linked oxidase domain protein
I6K55_RS09115	COG1686	Belongs to the peptidase S11 family
I6K55_RS09125	COG0586	Pfam SNARE associated Golgi protein
I6K55_RS09130	COG1538	Outer membrane efflux protein
I6K55_RS09135	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS09150	COG3659	wide pore channel activity
I6K55_RS09155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K55_RS09165	COG1346	cytolysis
I6K55_RS09175	COG2949	membrane
I6K55_RS09185	COG1129	ABC transporter
I6K55_RS09200	COG2311	Membrane
I6K55_RS09215	COG4771	TonB-dependent receptor
I6K55_RS09220	COG0833	amino acid
I6K55_RS09225	COG0583	DNA-binding transcription factor activity
I6K55_RS09230	COG2855	membrane
I6K55_RS09240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K55_RS09240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K55_RS09240	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K55_RS09245	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K55_RS09250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS09250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS09275	COG1312	Catalyzes the dehydration of D-mannonate
I6K55_RS09280	COG0246	Mannitol dehydrogenase
I6K55_RS09285	COG0523	cobalamin synthesis protein
I6K55_RS09290	COG0671	phosphoesterase, PA-phosphatase related
I6K55_RS09295	COG0791	NLP P60 protein
I6K55_RS09300	COG2200	EAL domain
I6K55_RS09305	COG4166	transmembrane transport
I6K55_RS09310	COG4174	ABC transporter (Permease)
I6K55_RS09315	COG4239	(ABC) transporter, permease
I6K55_RS09320	COG4172	Belongs to the ABC transporter superfamily
I6K55_RS09330	COG2814	Major facilitator Superfamily
I6K55_RS09335	COG1187	pseudouridine synthase activity
I6K55_RS09340	COG1061	Type III restriction enzyme res subunit
I6K55_RS09360	COG0494	nUDIX hydrolase
I6K55_RS09365	COG1349	DNA-binding transcription factor activity
I6K55_RS09390	COG0628	permease
I6K55_RS09405	COG0659	secondary active sulfate transmembrane transporter activity
I6K55_RS09410	COG2239	Acts as a magnesium transporter
I6K55_RS09415	COG4615	Cyclic peptide transporter
I6K55_RS09420	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K55_RS09425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K55_RS09425	COG2169	Transcriptional regulator
I6K55_RS09440	COG0642	Histidine kinase
I6K55_RS09440	COG2198	Histidine kinase
I6K55_RS09450	COG2205	protein histidine kinase activity
I6K55_RS09450	COG0784	Response regulator, receiver
I6K55_RS09475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K55_RS09480	COG0584	glycerophosphoryl diester phosphodiesterase
I6K55_RS09485	COG2271	Major facilitator Superfamily
I6K55_RS09490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K55_RS09500	COG0247	lactate metabolic process
I6K55_RS09510	COG2271	Major facilitator Superfamily
I6K55_RS09520	COG1414	Transcriptional regulator
I6K55_RS09535	COG5464	transposase or invertase
I6K55_RS09545	COG0318	PFAM AMP-dependent synthetase and ligase
I6K55_RS09570	COG1169	isochorismate synthase
I6K55_RS09575	COG2153	protein acetylation
I6K55_RS09590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K55_RS09595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K55_RS09605	COG0839	Belongs to the complex I subunit 6 family
I6K55_RS09650	COG0583	DNA-binding transcription factor activity
I6K55_RS09655	COG0436	Aminotransferase
I6K55_RS09665	COG0490	domain, Protein
I6K55_RS09665	COG0471	metal ion transport
I6K55_RS09670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K55_RS09690	COG0280	phosphate acetyltransferase
I6K55_RS09690	COG0857	belongs to the CobB CobQ family
I6K55_RS09695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K55_RS09700	COG0622	Phosphoesterase
I6K55_RS09705	COG0625	glutathione transferase activity
I6K55_RS09710	COG0625	glutathione transferase activity
I6K55_RS09715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K55_RS09720	COG1090	epimerase
I6K55_RS09735	COG4598	ABC transporter
I6K55_RS09740	COG4160	amino acid transport
I6K55_RS09765	COG0163	prenyltransferase activity
I6K55_RS09770	COG0833	amino acid
I6K55_RS09775	COG3457	Alanine racemase
I6K55_RS09780	COG0531	amino acid
I6K55_RS09790	COG3829	transcription factor binding
I6K55_RS09795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K55_RS09800	COG1286	toxin biosynthetic process
I6K55_RS09805	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K55_RS09810	COG0285	dihydrofolate synthase activity
I6K55_RS09820	COG0586	Pfam SNARE associated Golgi protein
I6K55_RS09830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K55_RS09850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K55_RS09865	COG3101	peptidyl-lysine hydroxylation
I6K55_RS09870	COG0730	response to heat
I6K55_RS09895	COG2062	phosphohistidine phosphatase, SixA
I6K55_RS09910	COG3691	Protein conserved in bacteria
I6K55_RS09920	COG2853	Lipoprotein
I6K55_RS09925	COG2116	formate transmembrane transporter activity
I6K55_RS09945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K55_RS09965	COG3188	usher protein
I6K55_RS09970	COG3121	Chaperone
I6K55_RS10000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K55_RS10005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K55_RS10010	COG2376	Dihydroxyacetone kinase
I6K55_RS10025	COG3716	PTS system mannose fructose sorbose family IID component
I6K55_RS10030	COG3715	PTS system
I6K55_RS10035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS10035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS10040	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS10040	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS10075	COG1122	ATPase activity
I6K55_RS10130	COG2171	N-acyltransferase activity
I6K55_RS10135	COG4221	oxidoreductase activity
I6K55_RS10140	COG2814	Major facilitator Superfamily
I6K55_RS10175	COG0583	DNA-binding transcription factor activity
I6K55_RS10180	COG0590	tRNA wobble adenosine to inosine editing
I6K55_RS10185	COG2807	transmembrane transport
I6K55_RS10195	COG0436	Aminotransferase
I6K55_RS10210	COG3275	phosphorelay sensor kinase activity
I6K55_RS10215	COG3279	Response regulator of the LytR AlgR family
I6K55_RS10230	COG3961	Belongs to the TPP enzyme family
I6K55_RS10235	COG0667	Aldo Keto reductase
I6K55_RS10250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K55_RS10255	COG2199	diguanylate cyclase activity
I6K55_RS10255	COG2200	EAL domain
I6K55_RS10270	COG3415	Transposase
I6K55_RS10275	COG3415	Transposase
I6K55_RS10305	COG0583	DNA-binding transcription factor activity
I6K55_RS10310	COG0385	Bile acid
I6K55_RS10315	COG3530	Putative quorum-sensing-regulated virulence factor
I6K55_RS10335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K55_RS10370	COG4319	ketosteroid isomerase
I6K55_RS10380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K55_RS10385	COG4208	sulfate ABC transporter
I6K55_RS10390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K55_RS10395	COG4150	thiosulfate binding
I6K55_RS10405	COG2837	iron assimilation
I6K55_RS10425	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K55_RS10515	COG4810	utilization protein
I6K55_RS10525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K55_RS10530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K55_RS10535	COG5342	invasion associated locus B
I6K55_RS10545	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K55_RS10545	COG0493	'glutamate synthase
I6K55_RS10550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K55_RS10560	COG1393	Belongs to the ArsC family
I6K55_RS10575	COG0400	carboxylic ester hydrolase activity
I6K55_RS10580	COG1444	tRNA N-acetyltransferase activity
I6K55_RS10585	COG2321	neutral zinc metallopeptidase
I6K55_RS10595	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K55_RS10605	COG2716	regulation of RNA biosynthetic process
I6K55_RS10610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K55_RS10615	COG0628	permease
I6K55_RS10625	COG4783	chaperone-mediated protein folding
I6K55_RS10630	COG1393	Belongs to the ArsC family
I6K55_RS10645	COG2233	PERMEase
I6K55_RS10655	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS10670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K55_RS10685	COG2200	EAL domain
I6K55_RS10705	COG0641	radical SAM
I6K55_RS10710	COG3119	arylsulfatase activity
I6K55_RS10720	COG0517	IMP dehydrogenase activity
I6K55_RS10720	COG0516	GMP reductase activity
I6K55_RS10730	COG1645	bacterial-type flagellum-dependent swarming motility
I6K55_RS10750	COG2976	Protein conserved in bacteria
I6K55_RS10780	COG4953	penicillin-binding protein 1C
I6K55_RS10785	COG2373	Large extracellular alpha-helical protein
I6K55_RS10790	COG2897	thiosulfate sulfurtransferase activity
I6K55_RS10810	COG2975	iron-sulfur cluster assembly
I6K55_RS10815	COG0633	Ferredoxin
I6K55_RS10835	COG0822	iron-sulfur transferase activity
I6K55_RS10865	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K55_RS10870	COG3683	transport system, periplasmic component
I6K55_RS10875	COG3711	transcriptional antiterminator
I6K55_RS10880	COG2814	Major facilitator Superfamily
I6K55_RS10885	COG2017	converts alpha-aldose to the beta-anomer
I6K55_RS10890	COG2814	Major facilitator Superfamily
I6K55_RS10890	COG0477	Major facilitator Superfamily
I6K55_RS10895	COG0457	Tetratricopeptide repeat
I6K55_RS10900	COG1940	carbohydrate kinase activity
I6K55_RS10905	COG2259	Doxx family
I6K55_RS10915	COG1017	nitric oxide dioxygenase activity
I6K55_RS10915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K55_RS10920	COG0347	Belongs to the P(II) protein family
I6K55_RS10925	COG2204	response regulator
I6K55_RS10930	COG3170	Tfp pilus assembly protein FimV
I6K55_RS10935	COG2205	protein histidine kinase activity
I6K55_RS10940	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K55_RS10940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K55_RS10955	COG0560	Phosphoserine phosphatase
I6K55_RS10960	COG1737	Transcriptional regulator
I6K55_RS10965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K55_RS10975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K55_RS10995	COG0681	Belongs to the peptidase S26 family
I6K55_RS11005	COG3086	response to oxidative stress
I6K55_RS11010	COG3026	antisigma factor binding
I6K55_RS11015	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K55_RS11030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K55_RS11040	COG0513	Belongs to the DEAD box helicase family
I6K55_RS11055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K55_RS11060	COG3118	belongs to the thioredoxin family
I6K55_RS11065	COG3148	PFAM DTW domain containing protein
I6K55_RS11075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K55_RS11080	COG5544	Lipoprotein
I6K55_RS11085	COG0477	Major facilitator Superfamily
I6K55_RS11110	COG0542	response to heat
I6K55_RS11125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K55_RS11130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K55_RS11140	COG0077	Prephenate dehydratase
I6K55_RS11140	COG1605	Chorismate mutase
I6K55_RS11150	COG1605	Chorismate mutase
I6K55_RS11150	COG0287	Prephenate dehydrogenase
I6K55_RS11155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K55_RS11165	COG2199	diguanylate cyclase activity
I6K55_RS11170	COG2885	chlorophyll binding
I6K55_RS11205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K55_RS11210	COG4137	Cytochrome C assembly protein
I6K55_RS11215	COG4536	flavin adenine dinucleotide binding
I6K55_RS11230	COG0497	DNA recombination
I6K55_RS11245	COG2867	negative regulation of translational initiation
I6K55_RS11275	COG3708	Transcriptional regulator
I6K55_RS11275	COG2207	Transcriptional regulator
I6K55_RS11280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS11315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS11320	COG1126	abc transporter atp-binding protein
I6K55_RS11325	COG0235	Class ii aldolase
I6K55_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS11355	COG3121	Chaperone
I6K55_RS11370	COG3121	Chaperone
I6K55_RS11375	COG3539	Fimbrial protein
I6K55_RS11385	COG3284	Transcriptional regulator
I6K55_RS11390	COG0583	DNA-binding transcription factor activity
I6K55_RS11400	COG0640	Transcriptional regulator
I6K55_RS11405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K55_RS11420	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K55_RS11435	COG4575	ribosome binding
I6K55_RS11440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K55_RS11445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K55_RS11450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K55_RS11460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K55_RS11475	COG4176	ABC-type proline glycine betaine transport system permease component
I6K55_RS11485	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K55_RS11495	COG1846	Transcriptional regulator
I6K55_RS11500	COG1566	PFAM secretion protein HlyD family protein
I6K55_RS11505	COG2814	Major facilitator Superfamily
I6K55_RS11510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K55_RS11530	COG1238	metal cluster binding
I6K55_RS11535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K55_RS11540	COG2823	Periplasmic or secreted lipoprotein
I6K55_RS11570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K55_RS11590	COG1546	Belongs to the CinA family
I6K55_RS11595	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K55_RS11600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K55_RS11605	COG1121	(ABC) transporter
I6K55_RS11610	COG2951	lytic endotransglycosylase activity
I6K55_RS11615	COG3730	PTS system glucitol sorbitol-specific
I6K55_RS11620	COG3732	PTS system glucitol sorbitol-specific
I6K55_RS11630	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS11635	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS11640	COG1349	DNA-binding transcription factor activity
I6K55_RS11665	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K55_RS11670	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K55_RS11675	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K55_RS11680	COG1609	Transcriptional regulator
I6K55_RS11685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS11685	COG1263	PTS System
I6K55_RS11690	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS11700	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K55_RS11710	COG3260	NADH ubiquinone oxidoreductase 20
I6K55_RS11715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K55_RS11720	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K55_RS11720	COG3261	NADH dehydrogenase
I6K55_RS11725	COG0650	Formate hydrogenlyase subunit 4
I6K55_RS11730	COG0651	ATP synthesis coupled electron transport
I6K55_RS11735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K55_RS11750	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K55_RS11755	COG0298	carbon dioxide binding
I6K55_RS11760	COG0409	Hydrogenase expression formation protein
I6K55_RS11765	COG0309	Hydrogenase expression formation protein (HypE)
I6K55_RS11775	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS11785	COG4580	involved in the transport of maltose and maltodextrins
I6K55_RS11790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS11795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS11800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS11805	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K55_RS11810	COG1940	carbohydrate kinase activity
I6K55_RS11815	COG1609	Transcriptional regulator
I6K55_RS11820	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K55_RS11825	COG1121	(ABC) transporter
I6K55_RS11830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K55_RS11835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K55_RS11850	COG0679	Auxin Efflux Carrier
I6K55_RS11870	COG3720	iron ion transport
I6K55_RS11875	COG4558	Periplasmic binding protein
I6K55_RS11880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS11920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K55_RS11925	COG0163	prenyltransferase activity
I6K55_RS11950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K55_RS11955	COG4942	peptidase
I6K55_RS11955	COG1388	LysM domain
I6K55_RS12015	COG2234	aminopeptidase activity
I6K55_RS12030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K55_RS12035	COG1518	maintenance of DNA repeat elements
I6K55_RS12050	COG1857	crispr-associated protein
I6K55_RS12065	COG1203	CRISPR-associated helicase, Cas3
I6K55_RS12085	COG0720	synthase
I6K55_RS12090	COG0602	queuosine metabolic process
I6K55_RS12110	COG3956	TIGRFAM MazG family protein
I6K55_RS12115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K55_RS12125	COG3850	Histidine kinase
I6K55_RS12125	COG3437	response regulator, receiver
I6K55_RS12125	COG2205	protein histidine kinase activity
I6K55_RS12125	COG4999	Histidine kinase
I6K55_RS12130	COG1929	Belongs to the glycerate kinase type-1 family
I6K55_RS12135	COG4948	Mandelate Racemase Muconate Lactonizing
I6K55_RS12140	COG4948	Mandelate Racemase Muconate Lactonizing
I6K55_RS12145	COG2271	Major facilitator Superfamily
I6K55_RS12150	COG0716	FMN binding
I6K55_RS12155	COG0564	pseudouridine synthase activity
I6K55_RS12160	COG3098	single-species biofilm formation
I6K55_RS12175	COG1611	Belongs to the LOG family
I6K55_RS12180	COG0814	amino acid
I6K55_RS12185	COG1760	l-serine dehydratase
I6K55_RS12190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K55_RS12200	COG0477	Major facilitator Superfamily
I6K55_RS12205	COG1464	Belongs to the NlpA lipoprotein family
I6K55_RS12210	COG2011	ABC-type metal ion transport system permease component
I6K55_RS12215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K55_RS12230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K55_RS12250	COG1454	alcohol dehydrogenase
I6K55_RS12255	COG0235	Class ii aldolase
I6K55_RS12260	COG0738	Major facilitator superfamily
I6K55_RS12280	COG1349	DNA-binding transcription factor activity
I6K55_RS12290	COG2363	Small membrane protein
I6K55_RS12295	COG0583	DNA-binding transcription factor activity
I6K55_RS12305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K55_RS12310	COG2166	iron-sulfur cluster assembly
I6K55_RS12315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K55_RS12320	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K55_RS12485	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K55_RS12515	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS12515	COG1454	alcohol dehydrogenase
I6K55_RS12520	COG4656	Part of a membrane complex involved in electron transport
I6K55_RS12550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K55_RS12555	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K55_RS12560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K55_RS12560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K55_RS12570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K55_RS12575	COG1074	ATP-dependent DNA helicase activity
I6K55_RS12580	COG1025	Belongs to the peptidase M16 family
I6K55_RS12585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K55_RS12590	COG4967	type IV pilus modification protein PilV
I6K55_RS12600	COG4795	General secretion pathway protein
I6K55_RS12605	COG2165	general secretion pathway protein
I6K55_RS12640	COG0861	Integral membrane protein TerC family
I6K55_RS12650	COG0667	Aldo Keto reductase
I6K55_RS12670	COG1609	Transcriptional regulator
I6K55_RS12680	COG2186	Transcriptional regulator
I6K55_RS12685	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS12690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS12695	COG1609	Transcriptional regulator
I6K55_RS12705	COG0583	DNA-binding transcription factor activity
I6K55_RS12710	COG1794	racemase activity, acting on amino acids and derivatives
I6K55_RS12715	COG1917	Cupin 2, conserved barrel domain protein
I6K55_RS12720	COG1175	transmembrane transport
I6K55_RS12725	COG0395	ABC-type sugar transport system, permease component
I6K55_RS12730	COG3842	ATPase activity
I6K55_RS12750	COG2223	nitrite transmembrane transporter activity
I6K55_RS12765	COG2814	Major facilitator Superfamily
I6K55_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS12775	COG0823	Involved in the tonB-independent uptake of proteins
I6K55_RS12785	COG0183	Belongs to the thiolase family
I6K55_RS12800	COG0814	amino acid
I6K55_RS12805	COG0667	Aldo Keto reductase
I6K55_RS12860	COG3539	Fimbrial protein
I6K55_RS12865	COG3121	Chaperone
I6K55_RS12870	COG3188	usher protein
I6K55_RS12875	COG3539	Fimbrial protein
I6K55_RS12880	COG3539	Fimbrial protein
I6K55_RS12885	COG3539	Fimbrial protein
I6K55_RS12895	COG2388	GCN5-related N-acetyl-transferase
I6K55_RS12900	COG3592	Divergent 4Fe-4S mono-cluster
I6K55_RS12915	COG1289	transmembrane transporter activity
I6K55_RS12920	COG1538	Outer membrane efflux protein
I6K55_RS12935	COG1393	Belongs to the ArsC family
I6K55_RS12940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K55_RS12980	COG0667	Aldo Keto reductase
I6K55_RS12995	COG2814	Major facilitator Superfamily
I6K55_RS13005	COG4942	peptidase
I6K55_RS13025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K55_RS13035	COG4974	Belongs to the 'phage' integrase family
I6K55_RS13040	COG0716	FMN binding
I6K55_RS13050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K55_RS13060	COG1272	protein, Hemolysin III
I6K55_RS13070	COG1737	Transcriptional regulator
I6K55_RS13075	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS13095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K55_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS13125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K55_RS13130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K55_RS13135	COG0006	proline dipeptidase activity
I6K55_RS13155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K55_RS13160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K55_RS13175	COG2968	Membrane
I6K55_RS13185	COG0668	transmembrane transport
I6K55_RS13190	COG0191	fructose-bisphosphate aldolase activity
I6K55_RS13205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K55_RS13210	COG0501	Belongs to the peptidase M48B family
I6K55_RS13230	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K55_RS13235	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS13265	COG1414	Transcriptional regulator
I6K55_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS13285	COG2146	nitrite reductase [NAD(P)H] activity
I6K55_RS13320	COG2814	Major facilitator Superfamily
I6K55_RS13330	COG2356	endonuclease I
I6K55_RS13335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K55_RS13340	COG0189	ligase activity
I6K55_RS13360	COG2805	Type II/IV secretion system protein
I6K55_RS13365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K55_RS13370	COG0762	integral membrane protein
I6K55_RS13385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K55_RS13395	COG3171	Protein conserved in bacteria
I6K55_RS13405	COG1194	a g-specific adenine glycosylase
I6K55_RS13420	COG2211	Major facilitator Superfamily
I6K55_RS13425	COG1982	Orn Lys Arg decarboxylase major
I6K55_RS13430	COG1811	Na channel or pump
I6K55_RS13445	COG0626	cystathionine gamma-synthase activity
I6K55_RS13450	COG0583	DNA-binding transcription factor activity
I6K55_RS13470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K55_RS13475	COG0754	glutathionylspermidine amidase activity
I6K55_RS13490	COG0625	glutathione transferase activity
I6K55_RS13515	COG2211	Major facilitator Superfamily
I6K55_RS13520	COG0848	biopolymer transport protein
I6K55_RS13530	COG0626	cystathionine gamma-synthase activity
I6K55_RS13535	COG0586	Pfam SNARE associated Golgi protein
I6K55_RS13540	COG2207	Transcriptional regulator
I6K55_RS13545	COG1979	alcohol dehydrogenase
I6K55_RS13550	COG0656	L-ascorbic acid biosynthetic process
I6K55_RS13560	COG1032	radical SAM domain protein
I6K55_RS13565	COG2132	Multicopper oxidase
I6K55_RS13570	COG0204	Acyl-transferase
I6K55_RS13575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K55_RS13580	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K55_RS13585	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K55_RS13595	COG0642	Histidine kinase
I6K55_RS13600	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K55_RS13605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K55_RS13615	COG3150	esterase
I6K55_RS13620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K55_RS13625	COG3151	Protein conserved in bacteria
I6K55_RS13630	COG0494	nUDIX hydrolase
I6K55_RS13645	COG0754	glutathionylspermidine amidase activity
I6K55_RS13650	COG3384	dioxygenase
I6K55_RS13665	COG2960	long-chain fatty acid transporting porin activity
I6K55_RS13690	COG3025	triphosphatase activity
I6K55_RS13695	COG4991	sh3 domain protein
I6K55_RS13710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K55_RS13775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K55_RS13780	COG0358	DNA primase activity
I6K55_RS13785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K55_RS13945	COG4695	Portal protein
I6K55_RS13985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K55_RS14020	COG4974	Belongs to the 'phage' integrase family
I6K55_RS14040	COG2197	response regulator
I6K55_RS14045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS14045	COG0784	Response regulator, receiver
I6K55_RS14045	COG2198	Histidine kinase
I6K55_RS14045	COG2205	protein histidine kinase activity
I6K55_RS14055	COG3247	response to pH
I6K55_RS14125	COG2376	Dihydroxyacetone kinase
I6K55_RS14130	COG1461	Dihydroxyacetone kinase
I6K55_RS14145	COG2375	cellular response to nickel ion
I6K55_RS14150	COG1695	Transcriptional regulator
I6K55_RS14200	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K55_RS14200	COG1902	pentaerythritol trinitrate reductase activity
I6K55_RS14220	COG1451	nucleotide metabolic process
I6K55_RS14225	COG0673	inositol 2-dehydrogenase activity
I6K55_RS14230	COG0861	Integral membrane protein TerC family
I6K55_RS14245	COG2721	sulfolactate sulfo-lyase activity
I6K55_RS14255	COG2271	Major facilitator Superfamily
I6K55_RS14260	COG2186	Transcriptional regulator
I6K55_RS14265	COG0586	Pfam SNARE associated Golgi protein
I6K55_RS14275	COG1422	Protein of unknown function (DUF1090)
I6K55_RS14280	COG4575	ribosome binding
I6K55_RS14285	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K55_RS14295	COG2259	Doxx family
I6K55_RS14300	COG0435	Glutathione S-transferase
I6K55_RS14305	COG3152	Membrane
I6K55_RS14310	COG0583	DNA-binding transcription factor activity
I6K55_RS14315	COG1741	Belongs to the pirin family
I6K55_RS14340	COG1929	Belongs to the glycerate kinase type-1 family
I6K55_RS14345	COG2084	Dehydrogenase
I6K55_RS14355	COG2271	Major facilitator Superfamily
I6K55_RS14360	COG2721	sulfolactate sulfo-lyase activity
I6K55_RS14365	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K55_RS14385	COG2823	Periplasmic or secreted lipoprotein
I6K55_RS14390	COG0701	Predicted permease
I6K55_RS14395	COG0702	epimerase
I6K55_RS14400	COG0693	protein deglycase activity
I6K55_RS14415	COG3153	acetyltransferase
I6K55_RS14420	COG3154	lipid carrier protein
I6K55_RS14425	COG0826	peptidase U32
I6K55_RS14430	COG0826	peptidase U32
I6K55_RS14435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K55_RS14440	COG0814	amino acid
I6K55_RS14485	COG0195	Participates in both transcription termination and antitermination
I6K55_RS14525	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K55_RS14535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K55_RS14540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K55_RS14550	COG1534	Rna-binding protein
I6K55_RS14560	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K55_RS14570	COG0697	spore germination
I6K55_RS14585	COG0142	geranyltranstransferase activity
I6K55_RS14590	COG3423	Transcriptional regulator
I6K55_RS14600	COG5007	Belongs to the BolA IbaG family
I6K55_RS14605	COG3113	response to antibiotic
I6K55_RS14610	COG2854	intermembrane phospholipid transfer
I6K55_RS14615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K55_RS14620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K55_RS14625	COG1127	ABC transporter
I6K55_RS14630	COG0530	calcium, potassium:sodium antiporter activity
I6K55_RS14640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K55_RS14645	COG3117	lipopolysaccharide transmembrane transporter activity
I6K55_RS14650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K55_RS14655	COG1137	ATPase activity
I6K55_RS14660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K55_RS14665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K55_RS14670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS14680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS14685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K55_RS14690	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K55_RS14695	COG5002	protein histidine kinase activity
I6K55_RS14695	COG2198	Histidine kinase
I6K55_RS14695	COG0784	Response regulator, receiver
I6K55_RS14700	COG1312	Catalyzes the dehydration of D-mannonate
I6K55_RS14705	COG1063	alcohol dehydrogenase
I6K55_RS14710	COG2271	Major facilitator Superfamily
I6K55_RS14715	COG1242	4 iron, 4 sulfur cluster binding
I6K55_RS14720	COG0067	glutamate synthase
I6K55_RS14720	COG0069	glutamate synthase activity
I6K55_RS14720	COG0070	glutamate synthase
I6K55_RS14725	COG0493	'glutamate synthase
I6K55_RS14735	COG2969	positive regulation of protein catabolic process
I6K55_RS14740	COG0625	glutathione transferase activity
I6K55_RS14760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K55_RS14765	COG3105	Protein conserved in bacteria
I6K55_RS14770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K55_RS14775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K55_RS14800	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K55_RS14805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K55_RS14810	COG0471	metal ion transport
I6K55_RS14845	COG2732	(Barnase) inhibitor
I6K55_RS14850	COG1289	transmembrane transporter activity
I6K55_RS14865	COG0583	DNA-binding transcription factor activity
I6K55_RS14870	COG0312	modulator of DNA gyrase
I6K55_RS14875	COG3164	Protein of unknown function
I6K55_RS14880	COG1530	ribonuclease E activity
I6K55_RS14890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K55_RS14895	COG1792	Involved in formation and maintenance of cell shape
I6K55_RS14900	COG1077	Cell shape determining protein MreB Mrl
I6K55_RS14905	COG2200	EAL domain
I6K55_RS14905	COG2199	diguanylate cyclase activity
I6K55_RS14930	COG0511	ligase activity, forming carbon-carbon bonds
I6K55_RS14935	COG0439	Biotin carboxylase
I6K55_RS14940	COG3924	membrane
I6K55_RS14945	COG4145	pantothenate transmembrane transporter activity
I6K55_RS14965	COG1309	transcriptional regulator
I6K55_RS14975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS14980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K55_RS15015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K55_RS15035	COG0551	DNA topoisomerase type I activity
I6K55_RS15045	COG0758	DNA mediated transformation
I6K55_RS15075	COG3036	rescue of stalled ribosome
I6K55_RS15080	COG0789	Transcriptional regulator
I6K55_RS15095	COG0202	RNA polymerase activity
I6K55_RS15120	COG0201	protein transport
I6K55_RS15185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K55_RS15200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K55_RS15225	COG0051	transcription antitermination factor activity, RNA binding
I6K55_RS15280	COG2964	Protein conserved in bacteria
I6K55_RS15285	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K55_RS15295	COG1047	Peptidyl-prolyl cis-trans
I6K55_RS15300	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K55_RS15315	COG0488	(ABC) transporter
I6K55_RS15320	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K55_RS15330	COG3954	Phosphoribulokinase
I6K55_RS15335	COG1765	OsmC-like protein
I6K55_RS15345	COG1289	transmembrane transporter activity
I6K55_RS15350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K55_RS15375	COG0738	Major facilitator superfamily
I6K55_RS15380	COG0402	S-adenosylhomocysteine deaminase activity
I6K55_RS15385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K55_RS15410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K55_RS15415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K55_RS15420	COG3266	domain, Protein
I6K55_RS15435	COG4796	Type ii and iii secretion system protein
I6K55_RS15460	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K55_RS15465	COG0494	nUDIX hydrolase
I6K55_RS15475	COG1011	Hydrolase
I6K55_RS15480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K55_RS15505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K55_RS15510	COG2183	response to ionizing radiation
I6K55_RS15515	COG1918	ferrous iron import across plasma membrane
I6K55_RS15540	COG1040	competence protein
I6K55_RS15550	COG2610	gluconate transmembrane transporter activity
I6K55_RS15555	COG1640	4-alpha-glucanotransferase
I6K55_RS15560	COG0058	SHG alpha-glucan phosphorylase activity
I6K55_RS15570	COG1349	DNA-binding transcription factor activity
I6K55_RS15585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K55_RS15600	COG0058	SHG alpha-glucan phosphorylase activity
I6K55_RS15625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K55_RS15635	COG2610	gluconate transmembrane transporter activity
I6K55_RS15640	COG3265	gluconokinase activity
I6K55_RS15645	COG1609	Transcriptional regulator
I6K55_RS15650	COG1741	Belongs to the pirin family
I6K55_RS15655	COG0673	inositol 2-dehydrogenase activity
I6K55_RS15665	COG1247	-acetyltransferase
I6K55_RS15670	COG0405	Gamma-glutamyltransferase
I6K55_RS15680	COG0584	glycerophosphoryl diester phosphodiesterase
I6K55_RS15730	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS15735	COG0683	leucine binding
I6K55_RS15745	COG0683	leucine binding
I6K55_RS15755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K55_RS15770	COG2177	Part of the ABC transporter FtsEX involved in
I6K55_RS15775	COG2884	Cell division ATP-binding protein ftsE
I6K55_RS15780	COG0552	protein localization to endoplasmic reticulum
I6K55_RS15785	COG0742	ribosomal rna small subunit methyltransferase
I6K55_RS15790	COG3776	membrane
I6K55_RS15800	COG3714	YhhN family
I6K55_RS15815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K55_RS15825	COG0477	Major facilitator Superfamily
I6K55_RS15830	COG0628	permease
I6K55_RS15870	COG3479	Phenolic acid decarboxylase
I6K55_RS15880	COG0747	negative chemotaxis
I6K55_RS15885	COG0601	transmembrane transport
I6K55_RS15890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K55_RS15900	COG1124	(ABC) transporter
I6K55_RS15910	COG2239	Acts as a magnesium transporter
I6K55_RS15915	COG2081	HI0933 family
I6K55_RS15920	COG0306	phosphate transporter
I6K55_RS15930	COG0589	response to stress
I6K55_RS15950	COG0671	phosphoesterase, PA-phosphatase related
I6K55_RS15955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K55_RS15960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K55_RS15970	COG1454	alcohol dehydrogenase
I6K55_RS15980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K55_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS15990	COG0583	DNA-binding transcription factor activity
I6K55_RS15995	COG1295	ribonuclease BN
I6K55_RS16000	COG0477	Major facilitator Superfamily
I6K55_RS16005	COG2982	Protein involved in outer membrane biogenesis
I6K55_RS16015	COG0612	Peptidase, M16
I6K55_RS16025	COG2200	EAL domain
I6K55_RS16025	COG2199	diguanylate cyclase activity
I6K55_RS16030	COG0457	Tetratricopeptide repeat
I6K55_RS16030	COG3118	belongs to the thioredoxin family
I6K55_RS16035	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K55_RS16040	COG1215	transferase activity, transferring glycosyl groups
I6K55_RS16070	COG2194	sulfuric ester hydrolase activity
I6K55_RS16085	COG0457	Tetratricopeptide repeat
I6K55_RS16090	COG1215	transferase activity, transferring glycosyl groups
I6K55_RS16100	COG2894	cell division
I6K55_RS16115	COG4608	Belongs to the ABC transporter superfamily
I6K55_RS16120	COG0444	Belongs to the ABC transporter superfamily
I6K55_RS16125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K55_RS16130	COG0601	transmembrane transport
I6K55_RS16135	COG0747	negative chemotaxis
I6K55_RS16160	COG2223	nitrite transmembrane transporter activity
I6K55_RS16165	COG5571	outer membrane autotransporter
I6K55_RS16170	COG2818	Glycosylase
I6K55_RS16175	COG0456	acetyltransferase
I6K55_RS16180	COG0243	molybdopterin cofactor binding
I6K55_RS16185	COG2885	chlorophyll binding
I6K55_RS16190	COG1609	Transcriptional regulator
I6K55_RS16200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K55_RS16220	COG2814	Major facilitator Superfamily
I6K55_RS16225	COG2944	sequence-specific DNA binding
I6K55_RS16230	COG1278	Cold shock
I6K55_RS16260	COG3274	enterobacterial common antigen metabolic process
I6K55_RS16265	COG4682	membrane
I6K55_RS16270	COG4682	membrane
I6K55_RS16285	COG4213	ABC transporter substrate-binding protein
I6K55_RS16295	COG4214	carbohydrate transport
I6K55_RS16300	COG2207	Transcriptional regulator
I6K55_RS16300	COG1609	Transcriptional regulator
I6K55_RS16305	COG2992	FlgJ-related protein
I6K55_RS16310	COG0366	Alpha amylase catalytic
I6K55_RS16315	COG3977	Valine--pyruvate aminotransferase
I6K55_RS16320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K55_RS16325	COG1414	Transcriptional regulator
I6K55_RS16330	COG3276	selenocysteine insertion sequence binding
I6K55_RS16340	COG0625	glutathione transferase activity
I6K55_RS16345	COG1566	PFAM secretion protein HlyD family protein
I6K55_RS16365	COG3722	fumarate hydratase activity
I6K55_RS16385	COG2186	Transcriptional regulator
I6K55_RS16395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K55_RS16415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K55_RS16420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K55_RS16430	COG4942	peptidase
I6K55_RS16435	COG2861	carbohydrate metabolic process
I6K55_RS16440	COG0463	Glycosyl transferase, family 2
I6K55_RS16450	COG0156	8-amino-7-oxononanoate synthase activity
I6K55_RS16465	COG0859	PFAM glycosyl transferase family 9
I6K55_RS16490	COG0859	PFAM glycosyl transferase family 9
I6K55_RS16515	COG1216	Glycosyl transferase, family 2
I6K55_RS16520	COG1519	Transferase
I6K55_RS16555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K55_RS16580	COG0842	Transport permease protein
I6K55_RS16585	COG1131	(ABC) transporter
I6K55_RS16605	COG1561	YicC-like family, N-terminal region
I6K55_RS16615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K55_RS16615	COG2169	Transcriptional regulator
I6K55_RS16625	COG2860	membrane
I6K55_RS16645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K55_RS16650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K55_RS16655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K55_RS16660	COG1494	fructose-1,6-bisphosphatase
I6K55_RS16670	COG3152	Membrane
I6K55_RS16695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K55_RS16715	COG0786	glutamate:sodium symporter activity
I6K55_RS16720	COG2233	PERMEase
I6K55_RS16725	COG2982	Protein involved in outer membrane biogenesis
I6K55_RS16730	COG1263	PTS System
I6K55_RS16730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS16735	COG1486	melibiose metabolic process
I6K55_RS16745	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K55_RS16750	COG2211	Major facilitator Superfamily
I6K55_RS16810	COG1064	alcohol dehydrogenase
I6K55_RS16820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K55_RS16835	COG1464	Belongs to the NlpA lipoprotein family
I6K55_RS16860	COG0583	DNA-binding transcription factor activity
I6K55_RS16895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K55_RS16905	COG2814	Major facilitator Superfamily
I6K55_RS16915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS16915	COG1263	PTS System
I6K55_RS16920	COG0697	spore germination
I6K55_RS16935	COG2828	Protein conserved in bacteria
I6K55_RS16940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K55_RS16945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K55_RS16950	COG0583	DNA-binding transcription factor activity
I6K55_RS16955	COG3384	dioxygenase
I6K55_RS16965	COG1609	Transcriptional regulator
I6K55_RS16975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS16975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS16980	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K55_RS16985	COG4580	involved in the transport of maltose and maltodextrins
I6K55_RS17010	COG2188	Transcriptional regulator
I6K55_RS17050	COG2271	Major facilitator Superfamily
I6K55_RS17060	COG2197	response regulator
I6K55_RS17065	COG0440	acetolactate synthase activity
I6K55_RS17070	COG0028	Belongs to the TPP enzyme family
I6K55_RS17100	COG2814	Major facilitator Superfamily
I6K55_RS17105	COG0583	DNA-binding transcription factor activity
I6K55_RS17115	COG2610	gluconate transmembrane transporter activity
I6K55_RS17135	COG2149	membrane
I6K55_RS17150	COG2188	Transcriptional regulator
I6K55_RS17175	COG5645	(Lipo)protein
I6K55_RS17180	COG0823	Involved in the tonB-independent uptake of proteins
I6K55_RS17185	COG2271	Major facilitator Superfamily
I6K55_RS17195	COG0800	Aldolase
I6K55_RS17200	COG3734	2-keto-3-deoxy-galactonokinase
I6K55_RS17205	COG2186	Transcriptional regulator
I6K55_RS17220	COG0561	phosphatase activity
I6K55_RS17225	COG0187	DNA topoisomerase II activity
I6K55_RS17255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K55_RS17270	COG0582	viral genome integration into host DNA
I6K55_RS17285	COG0717	Belongs to the dCTP deaminase family
I6K55_RS17330	COG0454	-acetyltransferase
I6K55_RS17350	COG2091	lysine biosynthetic process via aminoadipic acid
I6K55_RS17355	COG0431	NADPH-dependent FMN reductase
I6K55_RS17360	COG2252	PERMEase
I6K55_RS17365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K55_RS17370	COG0363	glucosamine-6-phosphate deaminase activity
I6K55_RS17375	COG2382	esterase
I6K55_RS17385	COG0704	Plays a role in the regulation of phosphate uptake
I6K55_RS17390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K55_RS17395	COG0581	inorganic phosphate transmembrane transporter activity
I6K55_RS17400	COG0573	inorganic phosphate transmembrane transporter activity
I6K55_RS17405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K55_RS17410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K55_RS17460	COG3312	ion transport
I6K55_RS17475	COG0716	FMN binding
I6K55_RS17480	COG1522	sequence-specific DNA binding
I6K55_RS17510	COG1129	ABC transporter
I6K55_RS17515	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS17525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K55_RS17530	COG1609	Transcriptional regulator
I6K55_RS17535	COG0477	Major facilitator Superfamily
I6K55_RS17540	COG2186	Transcriptional regulator
I6K55_RS17565	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K55_RS17575	COG3084	Protein conserved in bacteria
I6K55_RS17580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K55_RS17590	COG0204	Acyl-transferase
I6K55_RS17610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K55_RS17625	COG3852	Histidine kinase
I6K55_RS17640	COG1011	Hydrolase
I6K55_RS17655	COG0456	acetyltransferase
I6K55_RS17665	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K55_RS17680	COG2864	formate dehydrogenase
I6K55_RS17685	COG0437	4 iron, 4 sulfur cluster binding
I6K55_RS17705	COG0205	6-phosphofructokinase activity
I6K55_RS17765	COG2211	Major facilitator Superfamily
I6K55_RS17775	COG1454	alcohol dehydrogenase
I6K55_RS17780	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS17785	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS17790	COG1129	ABC transporter
I6K55_RS17830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K55_RS17835	COG2258	MOSC domain
I6K55_RS17840	COG2205	protein histidine kinase activity
I6K55_RS17845	COG0745	RESPONSE REGULATOR receiver
I6K55_RS17850	COG3678	ATP-independent chaperone mediated protein folding
I6K55_RS17870	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K55_RS17885	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K55_RS17890	COG1609	Transcriptional regulator
I6K55_RS17895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K55_RS17910	COG0626	cystathionine gamma-synthase activity
I6K55_RS17915	COG0460	homoserine dehydrogenase
I6K55_RS17915	COG0527	aspartate kinase activity
I6K55_RS17925	COG0737	Belongs to the 5'-nucleotidase family
I6K55_RS17935	COG0583	DNA-binding transcription factor activity
I6K55_RS17945	COG0697	spore germination
I6K55_RS17950	COG0371	Dehydrogenase
I6K55_RS17960	COG2207	Transcriptional regulator
I6K55_RS17965	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K55_RS17980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K55_RS17995	COG0583	DNA-binding transcription factor activity
I6K55_RS18070	COG3085	chromosome segregation
I6K55_RS18095	COG3978	acetolactate synthase activity
I6K55_RS18110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K55_RS18115	COG0583	DNA-binding transcription factor activity
I6K55_RS18125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K55_RS18130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K55_RS18140	COG1811	Na channel or pump
I6K55_RS18165	COG3118	belongs to the thioredoxin family
I6K55_RS18170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K55_RS18175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K55_RS18185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K55_RS18190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K55_RS18195	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K55_RS18200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K55_RS18205	COG0456	acetyltransferase
I6K55_RS18210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K55_RS18215	COG2244	polysaccharide biosynthetic process
I6K55_RS18260	COG3071	HemY protein
I6K55_RS18265	COG2959	enzyme of heme biosynthesis
I6K55_RS18280	COG3072	Adenylate cyclase
I6K55_RS18310	COG1011	Hydrolase
I6K55_RS18315	COG0210	DNA helicase
I6K55_RS18345	COG1280	lysine exporter protein (LysE YggA)
I6K55_RS18355	COG1280	lysine exporter protein (LysE YggA)
I6K55_RS18360	COG2267	carboxylic ester hydrolase activity
I6K55_RS18365	COG0561	phosphatase activity
I6K55_RS18370	COG0697	spore germination
I6K55_RS18375	COG0583	DNA-binding transcription factor activity
I6K55_RS18405	COG3165	ubiquinone biosynthetic process from chorismate
I6K55_RS18425	COG0805	protein transport
I6K55_RS18465	COG1739	Uncharacterized protein family UPF0029
I6K55_RS18475	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K55_RS18550	COG0250	Participates in transcription elongation, termination and antitermination
I6K55_RS18585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K55_RS18590	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K55_RS18600	COG3706	GGDEF domain
I6K55_RS18615	COG2104	thiamine diphosphate biosynthetic process
I6K55_RS18620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K55_RS18635	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K55_RS18670	COG3678	ATP-independent chaperone mediated protein folding
I6K55_RS18675	COG4191	Histidine kinase
I6K55_RS18685	COG0151	Belongs to the GarS family
I6K55_RS18715	COG0456	acetyltransferase
I6K55_RS18725	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K55_RS18755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K55_RS18810	COG0527	aspartate kinase activity
I6K55_RS18820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K55_RS18830	COG0251	oxidation-reduction process
I6K55_RS18900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K55_RS18910	COG0534	Mate efflux family protein
I6K55_RS18920	COG3237	CsbD-like
I6K55_RS18925	COG0735	belongs to the Fur family
I6K55_RS18935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K55_RS18950	COG0305	Participates in initiation and elongation during chromosome replication
I6K55_RS18955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K55_RS18970	COG0432	Pfam Uncharacterised protein family UPF0047
I6K55_RS18975	COG2315	Protein conserved in bacteria
I6K55_RS18990	COG0741	lytic transglycosylase activity
I6K55_RS18995	COG4771	TonB-dependent receptor
I6K55_RS19015	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K55_RS19025	COG0483	inositol monophosphate 1-phosphatase activity
I6K55_RS19030	COG1609	Transcriptional regulator
I6K55_RS19035	COG1234	tRNA 3'-trailer cleavage
I6K55_RS19065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K55_RS19075	COG0789	Transcriptional regulator
I6K55_RS19080	COG0625	glutathione transferase activity
I6K55_RS19085	COG2252	PERMEase
I6K55_RS19090	COG0025	NhaP-type Na H and K H
I6K55_RS19095	COG0583	DNA-binding transcription factor activity
I6K55_RS19100	COG1380	Effector of murein hydrolase LrgA
I6K55_RS19105	COG1346	cytolysis
I6K55_RS19110	COG3539	Fimbrial protein
I6K55_RS19140	COG3162	membrane
I6K55_RS19145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K55_RS19155	COG1301	dicarboxylic acid transport
I6K55_RS19160	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K55_RS19195	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS19200	COG1129	ABC transporter
I6K55_RS19205	COG4191	Histidine kinase
I6K55_RS19205	COG0784	Response regulator, receiver
I6K55_RS19215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K55_RS19230	COG4778	phosphonate C-P lyase system protein PhnL
I6K55_RS19235	COG4107	phosphonate C-P lyase system protein PhnK
I6K55_RS19240	COG3627	carbon phosphorus lyase activity
I6K55_RS19245	COG3626	phosphonate metabolism
I6K55_RS19250	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K55_RS19255	COG3624	Phosphonate C-P lyase system protein PhnG
I6K55_RS19260	COG2188	Transcriptional regulator
I6K55_RS19265	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K55_RS19270	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K55_RS19280	COG2169	Transcriptional regulator
I6K55_RS19285	COG1486	melibiose metabolic process
I6K55_RS19330	COG0861	Integral membrane protein TerC family
I6K55_RS19345	COG1215	transferase activity, transferring glycosyl groups
I6K55_RS19350	COG1649	PFAM Uncharacterised BCR, COG1649
I6K55_RS19350	COG0726	polysaccharide deacetylase
I6K55_RS19355	COG0457	Tetratricopeptide repeat
I6K55_RS19400	COG1309	transcriptional regulator
I6K55_RS19415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K55_RS19420	COG1027	Aspartate ammonia-lyase
I6K55_RS19425	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K55_RS19430	COG0531	amino acid
I6K55_RS19495	COG1509	lysine 2,3-aminomutase activity
I6K55_RS19510	COG5510	response to toxic substance
I6K55_RS19515	COG2076	Multidrug Resistance protein
I6K55_RS19535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K55_RS19540	COG1053	succinate dehydrogenase
I6K55_RS19555	COG3264	Mechanosensitive ion channel
I6K55_RS19555	COG1511	domain protein
I6K55_RS19575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS19595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K55_RS19600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K55_RS19600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K55_RS19605	COG0802	atpase or kinase
I6K55_RS19610	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K55_RS19630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K55_RS19635	COG0330	HflC and HflK could
I6K55_RS19640	COG0330	HflC and HflK could
I6K55_RS19650	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K55_RS19665	COG0557	exoribonuclease II activity
I6K55_RS19670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K55_RS19675	COG1960	acyl-CoA dehydrogenase activity
I6K55_RS19685	COG3650	response to hydrogen peroxide
I6K55_RS19690	COG1073	alpha beta
I6K55_RS19750	COG2965	DNA replication, synthesis of RNA primer
I6K55_RS19755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K55_RS19765	COG3061	Opacity-associated protein A
I6K55_RS19770	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K55_RS19775	COG1113	amino acid transport
I6K55_RS19785	COG0697	spore germination
I6K55_RS19795	COG0702	epimerase
I6K55_RS19800	COG1733	regulation of RNA biosynthetic process
I6K55_RS19815	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K55_RS19830	COG1253	flavin adenine dinucleotide binding
I6K55_RS19840	COG0729	surface antigen
I6K55_RS19845	COG2911	Protein conserved in bacteria
I6K55_RS19850	COG2105	PFAM AIG2 family protein
I6K55_RS19870	COG1879	ABC-type sugar transport system periplasmic component
I6K55_RS19875	COG1129	ABC transporter
I6K55_RS19880	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS19885	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS19895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K55_RS19920	COG0312	modulator of DNA gyrase
I6K55_RS19955	COG3964	amidohydrolase
I6K55_RS19970	COG2706	6-phosphogluconolactonase activity
I6K55_RS19975	COG3711	transcriptional antiterminator
I6K55_RS19975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS19980	COG3077	Addiction module antitoxin, RelB DinJ family
I6K55_RS19985	COG2026	Addiction module toxin, RelE StbE family
I6K55_RS19990	COG0602	queuosine metabolic process
I6K55_RS20015	COG1486	melibiose metabolic process
I6K55_RS20020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS20025	COG0366	Alpha amylase catalytic
I6K55_RS20030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS20030	COG1263	PTS System
I6K55_RS20065	COG2731	YhcH YjgK YiaL family protein
I6K55_RS20090	COG0525	valine-tRNA ligase activity
I6K55_RS20095	COG2927	DNA polymerase III (CHI subunit)
I6K55_RS20105	COG0795	lipopolysaccharide-transporting ATPase activity
I6K55_RS20110	COG0795	lipopolysaccharide-transporting ATPase activity
I6K55_RS20115	COG0433	COG0433 Predicted ATPase
I6K55_RS20130	COG3718	enzyme involved in inositol metabolism
I6K55_RS20135	COG0837	glucose binding
I6K55_RS20135	COG1737	Transcriptional regulator
I6K55_RS20140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K55_RS20145	COG3962	Belongs to the TPP enzyme family
I6K55_RS20155	COG1082	Xylose isomerase domain protein TIM barrel
I6K55_RS20170	COG3842	ATPase activity
I6K55_RS20175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K55_RS20180	COG0395	ABC-type sugar transport system, permease component
I6K55_RS20185	COG1175	transmembrane transport
I6K55_RS20190	COG1064	alcohol dehydrogenase
I6K55_RS20195	COG0659	secondary active sulfate transmembrane transporter activity
I6K55_RS20200	COG0288	reversible hydration of carbon dioxide
I6K55_RS20210	COG0582	viral genome integration into host DNA
I6K55_RS20240	COG2963	transposase activity
I6K55_RS20255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6K55_RS20265	COG1111	helicase
I6K55_RS20265	COG1205	dead DEAH box helicase
I6K55_RS20270	COG0210	DNA helicase
I6K55_RS20280	COG4372	Transposase
I6K55_RS20285	COG3436	PFAM IS66 Orf2 family protein
I6K55_RS20300	COG0582	viral genome integration into host DNA
I6K55_RS20340	COG3436	PFAM IS66 Orf2 family protein
I6K55_RS20345	COG4372	Transposase
I6K55_RS20370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K55_RS20390	COG3328	transposase activity
I6K55_RS20425	COG2003	Belongs to the UPF0758 family
I6K55_RS20555	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K55_RS20560	COG2211	Major facilitator Superfamily
I6K55_RS20565	COG2115	Belongs to the xylose isomerase family
I6K55_RS20570	COG4580	involved in the transport of maltose and maltodextrins
I6K55_RS20575	COG3272	Protein of unknown function (DUF1722)
I6K55_RS20595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K55_RS20610	COG0300	oxidoreductase activity
I6K55_RS20620	COG0789	Transcriptional regulator
I6K55_RS20625	COG3040	lipid binding
I6K55_RS20635	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K55_RS20640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS20645	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS20650	COG1538	Outer membrane efflux protein
I6K55_RS20655	COG0745	RESPONSE REGULATOR receiver
I6K55_RS20660	COG5002	protein histidine kinase activity
I6K55_RS20675	COG2850	peptidyl-arginine hydroxylation
I6K55_RS20705	COG0842	Transport permease protein
I6K55_RS20710	COG0842	Transport permease protein
I6K55_RS20710	COG1129	ABC transporter
I6K55_RS20715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS20725	COG1879	ABC-type sugar transport system periplasmic component
I6K55_RS20730	COG1129	ABC transporter
I6K55_RS20735	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS20745	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K55_RS20750	COG0583	DNA-binding transcription factor activity
I6K55_RS20785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K55_RS20790	COG5457	Domain of unknown function (DUF1127)
I6K55_RS20800	COG1566	PFAM secretion protein HlyD family protein
I6K55_RS20815	COG1924	4 iron, 4 sulfur cluster binding
I6K55_RS20820	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K55_RS20835	COG2733	membrane
I6K55_RS20845	COG2207	Transcriptional regulator
I6K55_RS20845	COG1917	Cupin 2, conserved barrel domain protein
I6K55_RS20850	COG5464	transposase or invertase
I6K55_RS20855	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS20865	COG0523	cobalamin synthesis protein
I6K55_RS20870	COG2879	small protein
I6K55_RS20875	COG1966	Carbon starvation protein
I6K55_RS20890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K55_RS20895	COG2368	4-hydroxyphenylacetate
I6K55_RS20915	COG3971	2-oxopent-4-enoate hydratase activity
I6K55_RS20925	COG3384	dioxygenase
I6K55_RS20930	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS20940	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K55_RS20950	COG1846	Transcriptional regulator
I6K55_RS20965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6K55_RS20965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K55_RS20980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K55_RS20985	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS20990	COG0531	amino acid
I6K55_RS21010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K55_RS21025	COG3734	2-keto-3-deoxy-galactonokinase
I6K55_RS21030	COG0800	Aldolase
I6K55_RS21035	COG1737	Transcriptional regulator
I6K55_RS21045	COG1214	PFAM Peptidase M22, glycoprotease
I6K55_RS21045	COG0456	acetyltransferase
I6K55_RS21050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K55_RS21050	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K55_RS21065	COG3715	PTS system
I6K55_RS21070	COG3716	PTS system mannose fructose sorbose family IID component
I6K55_RS21075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K55_RS21085	COG5464	transposase or invertase
I6K55_RS21100	COG1484	DNA-dependent DNA replication
I6K55_RS21115	COG2966	Psort location CytoplasmicMembrane, score
I6K55_RS21130	COG2197	response regulator
I6K55_RS21135	COG2197	response regulator
I6K55_RS21140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K55_RS21145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS21145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K55_RS21150	COG4114	ferric iron reductase
I6K55_RS21155	COG3706	GGDEF domain
I6K55_RS21190	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K55_RS21195	COG0456	acetyltransferase
I6K55_RS21200	COG1011	Hydrolase
I6K55_RS21210	COG2823	Periplasmic or secreted lipoprotein
I6K55_RS21220	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K55_RS21225	COG0084	hydrolase, TatD family'
I6K55_RS21230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K55_RS21260	COG3726	membrane protein affecting hemolysin expression
I6K55_RS21265	COG0560	Phosphoserine phosphatase
I6K55_RS21270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K55_RS21280	COG0488	(ABC) transporter
I6K55_RS21285	COG0741	lytic transglycosylase activity
I6K55_RS21305	COG2207	Transcriptional regulator
I6K55_RS21305	COG3708	Transcriptional regulator
I6K55_RS21310	COG3045	CreA protein
I6K55_RS21315	COG0745	RESPONSE REGULATOR receiver
I6K55_RS21320	COG2205	protein histidine kinase activity
I6K55_RS21325	COG4452	Inner membrane protein CreD
I6K55_RS21330	COG0745	RESPONSE REGULATOR receiver
I6K55_RS21340	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K55_RS21350	COG0460	homoserine dehydrogenase
I6K55_RS21350	COG0527	aspartate kinase activity
I6K55_RS21360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K55_RS21375	COG1115	amino acid carrier protein
I6K55_RS21380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K55_RS21385	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K55_RS21390	COG0477	Major facilitator Superfamily
I6K55_RS21395	COG1584	GPR1 FUN34 yaaH family protein
I6K55_RS21400	COG4735	regulation of single-species biofilm formation
I6K55_RS21425	COG0583	DNA-binding transcription factor activity
I6K55_RS21435	COG0196	riboflavin kinase activity
I6K55_RS21450	COG1047	Peptidyl-prolyl cis-trans
I6K55_RS21475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K55_RS21540	COG0505	Belongs to the CarA family
I6K55_RS21585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K55_RS21595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K55_RS21600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K55_RS21615	COG3493	citrate carrier protein
I6K55_RS21625	COG0564	pseudouridine synthase activity
I6K55_RS21635	COG0417	DNA replication proofreading
I6K55_RS21640	COG0235	Class ii aldolase
I6K55_RS21660	COG0586	Pfam SNARE associated Golgi protein
I6K55_RS21670	COG1178	ABC-type Fe3 transport system permease component
I6K55_RS21690	COG2814	Major facilitator Superfamily
I6K55_RS21695	COG2271	Major facilitator Superfamily
I6K55_RS21700	COG0583	DNA-binding transcription factor activity
I6K55_RS21710	COG0738	Major facilitator superfamily
I6K55_RS21755	COG0028	Belongs to the TPP enzyme family
I6K55_RS21765	COG1609	Transcriptional regulator
I6K55_RS21785	COG0768	penicillin binding
I6K55_RS21790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K55_RS21795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K55_RS21810	COG0772	Belongs to the SEDS family
I6K55_RS21835	COG0849	cell division
I6K55_RS21840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K55_RS21860	COG0494	nUDIX hydrolase
I6K55_RS21885	COG1459	type II secretion system
I6K55_RS21890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K55_RS21895	COG4969	Belongs to the N-Me-Phe pilin family
I6K55_RS21905	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K55_RS21915	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K55_RS21920	COG2211	Major facilitator Superfamily
I6K55_RS21925	COG1113	amino acid transport
I6K55_RS21930	COG2186	Transcriptional regulator
I6K55_RS21935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K55_RS21940	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K55_RS21945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K55_RS21960	COG3064	Membrane
I6K55_RS22000	COG2132	Multicopper oxidase
I6K55_RS22005	COG4993	Dehydrogenase
I6K55_RS22020	COG0288	reversible hydration of carbon dioxide
I6K55_RS22025	COG1131	(ABC) transporter
I6K55_RS22030	COG0842	Transport permease protein
I6K55_RS22035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS22040	COG0726	polysaccharide deacetylase
I6K55_RS22060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K55_RS22065	COG0617	tRNA 3'-terminal CCA addition
I6K55_RS22085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K55_RS22090	COG1643	Atp-dependent helicase
I6K55_RS22180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K55_RS22185	COG4774	siderophore transport
I6K55_RS22190	COG1120	ATPase activity
I6K55_RS22195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K55_RS22200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS22220	COG2860	membrane
I6K55_RS22240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K55_RS22245	COG3835	regulator
I6K55_RS22260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K55_RS22265	COG0024	Methionine aminopeptidase
I6K55_RS22290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K55_RS22300	COG0575	Belongs to the CDS family
I6K55_RS22305	COG0750	zinc metalloprotease
I6K55_RS22315	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K55_RS22345	COG0587	DNA-directed DNA polymerase activity
I6K55_RS22355	COG1982	Orn Lys Arg decarboxylase major
I6K55_RS22360	COG0346	lactoylglutathione lyase activity
I6K55_RS22370	COG4568	rho-dependent transcription termination
I6K55_RS22385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K55_RS22390	COG3015	lipoprotein NlpE involved in copper resistance
I6K55_RS22395	COG0791	NLP P60 protein
I6K55_RS22405	COG1720	tRNA m6t6A37 methyltransferase activity
I6K55_RS22415	COG1464	Belongs to the NlpA lipoprotein family
I6K55_RS22420	COG2011	ABC-type metal ion transport system permease component
I6K55_RS22430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K55_RS22465	COG0656	L-ascorbic acid biosynthetic process
I6K55_RS22470	COG0583	DNA-binding transcription factor activity
I6K55_RS22475	COG2814	Major facilitator Superfamily
I6K55_RS22485	COG2226	methyltransferase
I6K55_RS22490	COG0741	lytic transglycosylase activity
I6K55_RS22490	COG1388	LysM domain
I6K55_RS22500	COG2226	methyltransferase
I6K55_RS22510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K55_RS22520	COG0583	DNA-binding transcription factor activity
I6K55_RS22530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K55_RS22535	COG1960	acyl-CoA dehydrogenase activity
I6K55_RS22545	COG0121	glutamine amidotransferase
I6K55_RS22550	COG3034	peptidoglycan biosynthetic process
I6K55_RS22565	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K55_RS22570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K55_RS22585	COG2991	Protein conserved in bacteria
I6K55_RS22600	COG0454	-acetyltransferase
I6K55_RS22605	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K55_RS22625	COG1802	Transcriptional regulator
I6K55_RS22630	COG1113	amino acid transport
I6K55_RS22635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K55_RS22640	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS22645	COG0579	oxidoreductase
I6K55_RS22660	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K55_RS22665	COG0625	glutathione transferase activity
I6K55_RS22670	COG3775	system Galactitol-specific IIC component
I6K55_RS22675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K55_RS22680	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS22685	COG1070	Carbohydrate kinase
I6K55_RS22705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K55_RS22710	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K55_RS22715	COG0022	dehydrogenase e1 component
I6K55_RS22720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K55_RS22725	COG2909	trisaccharide binding
I6K55_RS22755	COG3188	usher protein
I6K55_RS22760	COG3121	Chaperone
I6K55_RS22795	COG0582	viral genome integration into host DNA
I6K55_RS22820	COG0791	NLP P60 protein
I6K55_RS22845	COG3639	organic phosphonate transmembrane transporter activity
I6K55_RS22855	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K55_RS22880	COG3188	usher protein
I6K55_RS22895	COG0765	amino acid transport
I6K55_RS22900	COG4597	amino acid ABC transporter
I6K55_RS22905	COG1126	abc transporter atp-binding protein
I6K55_RS22910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS22950	COG4302	ethanolamine ammonia-lyase activity
I6K55_RS22955	COG4303	Ethanolamine ammonia lyase large subunit
I6K55_RS22970	COG0833	amino acid
I6K55_RS22975	COG2040	homocysteine
I6K55_RS22980	COG4521	taurine ABC transporter
I6K55_RS22985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K55_RS22990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K55_RS22995	COG2175	clavaminate synthase activity
I6K55_RS23005	COG1943	Transposase
I6K55_RS23010	COG0113	porphobilinogen synthase activity
I6K55_RS23015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K55_RS23020	COG1335	isochorismatase
I6K55_RS23025	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K55_RS23065	COG1785	Belongs to the alkaline phosphatase family
I6K55_RS23075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K55_RS23085	COG3416	Protein conserved in bacteria
I6K55_RS23090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K55_RS23100	COG4126	flavin adenine dinucleotide binding
I6K55_RS23115	COG1940	carbohydrate kinase activity
I6K55_RS23120	COG0419	ATPase involved in DNA repair
I6K55_RS23125	COG0420	3'-5' exonuclease activity
I6K55_RS23150	COG0366	Alpha amylase catalytic
I6K55_RS23155	COG0583	DNA-binding transcription factor activity
I6K55_RS23160	COG1335	isochorismatase
I6K55_RS23170	COG1228	amidohydrolase
I6K55_RS23180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K55_RS23195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K55_RS23200	COG0450	alkyl hydroperoxide reductase
I6K55_RS23225	COG1862	Preprotein translocase
I6K55_RS23230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K55_RS23235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K55_RS23255	COG4238	major outer membrane lipoprotein
I6K55_RS23265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K55_RS23265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K55_RS23285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K55_RS23290	COG0667	Aldo Keto reductase
I6K55_RS23300	COG0142	geranyltranstransferase activity
I6K55_RS23320	COG0693	protein deglycase activity
I6K55_RS23325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K55_RS23335	COG2814	Major facilitator Superfamily
I6K55_RS23340	COG0673	inositol 2-dehydrogenase activity
I6K55_RS23355	COG1053	succinate dehydrogenase
I6K55_RS23365	COG1053	succinate dehydrogenase
I6K55_RS23370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K55_RS23375	COG1414	Transcriptional regulator
I6K55_RS23390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K55_RS23395	COG1845	cytochrome c oxidase, subunit III
I6K55_RS23400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K55_RS23405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K55_RS23410	COG2223	nitrite transmembrane transporter activity
I6K55_RS23415	COG3056	Lipoprotein
I6K55_RS23420	COG0271	Belongs to the BolA IbaG family
I6K55_RS23440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K55_RS23445	COG0776	regulation of translation
I6K55_RS23450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K55_RS23455	COG1555	photosystem II stabilization
I6K55_RS23460	COG0824	Thioesterase
I6K55_RS23470	COG4533	DNA binding
I6K55_RS23485	COG1522	sequence-specific DNA binding
I6K55_RS23490	COG1132	(ABC) transporter
I6K55_RS23495	COG1132	(ABC) transporter
I6K55_RS23500	COG0347	Belongs to the P(II) protein family
I6K55_RS23505	COG0004	ammonium transporteR
I6K55_RS23510	COG1946	Acyl-CoA thioesterase
I6K55_RS23515	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K55_RS23520	COG3695	enzyme binding
I6K55_RS23550	COG2364	Membrane
I6K55_RS23565	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K55_RS23575	COG2182	Extracellular solute-binding protein
I6K55_RS23580	COG1175	transmembrane transport
I6K55_RS23585	COG3833	ABC-type maltose transport systems, permease component
I6K55_RS23590	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K55_RS23595	COG1874	Beta-galactosidase
I6K55_RS23645	COG0110	maltose O-acetyltransferase activity
I6K55_RS23660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K55_RS23665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS23670	COG1309	transcriptional regulator
I6K55_RS23675	COG1196	nuclear chromosome segregation
I6K55_RS23675	COG3264	Mechanosensitive ion channel
I6K55_RS23680	COG5464	transposase or invertase
I6K55_RS23690	COG3923	Primosomal replication protein n
I6K55_RS23695	COG2832	Protein of unknown function (DUF454)
I6K55_RS23735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K55_RS23740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K55_RS23740	COG4651	solute:proton antiporter activity
I6K55_RS23745	COG2223	nitrite transmembrane transporter activity
I6K55_RS23755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K55_RS23760	COG3735	TraB family
I6K55_RS23775	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K55_RS23780	COG0330	HflC and HflK could
I6K55_RS23785	COG4619	ABC transporter
I6K55_RS23790	COG0390	transport system, permease component
I6K55_RS23795	COG3118	belongs to the thioredoxin family
I6K55_RS23800	COG0300	oxidoreductase activity
I6K55_RS23805	COG2755	lipolytic protein G-D-S-L family
I6K55_RS23810	COG4181	ATPase activity
I6K55_RS23815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K55_RS23835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K55_RS23840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K55_RS23855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K55_RS23865	COG2501	S4 domain
I6K55_RS23915	COG3539	Fimbrial protein
I6K55_RS23920	COG3121	Chaperone
I6K55_RS23925	COG3188	usher protein
I6K55_RS23940	COG1560	Kdo2-lipid A biosynthetic process
I6K55_RS23950	COG3710	Transcriptional regulator
I6K55_RS23955	COG0531	amino acid
I6K55_RS23960	COG1982	Orn Lys Arg decarboxylase major
I6K55_RS23965	COG3104	oligopeptide transport
I6K55_RS23995	COG0673	inositol 2-dehydrogenase activity
I6K55_RS24010	COG1129	ABC transporter
I6K55_RS24015	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS24060	COG1566	PFAM secretion protein HlyD family protein
I6K55_RS24065	COG1120	ATPase activity
I6K55_RS24070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS24100	COG1473	amidohydrolase
I6K55_RS24105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS24110	COG0667	Aldo Keto reductase
I6K55_RS24150	COG4680	protein conserved in bacteria
I6K55_RS24165	COG0531	amino acid
I6K55_RS24175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K55_RS24180	COG1012	belongs to the aldehyde dehydrogenase family
I6K55_RS24195	COG1113	amino acid transport
I6K55_RS24200	COG2211	Major facilitator Superfamily
I6K55_RS24210	COG0673	inositol 2-dehydrogenase activity
I6K55_RS24220	COG1609	Transcriptional regulator
I6K55_RS24225	COG0668	transmembrane transport
I6K55_RS24230	COG0477	Major facilitator Superfamily
I6K55_RS24245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K55_RS24245	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K55_RS24250	COG2222	sugar isomerase
I6K55_RS24255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K55_RS24260	COG3716	PTS system mannose fructose sorbose family IID component
I6K55_RS24270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K55_RS24280	COG0778	Nitroreductase
I6K55_RS24285	COG2315	Protein conserved in bacteria
I6K55_RS24325	COG3698	Phosphodiester glycosidase
I6K55_RS24335	COG4166	transmembrane transport
I6K55_RS24345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K55_RS24350	COG4608	Belongs to the ABC transporter superfamily
I6K55_RS24365	COG0697	spore germination
I6K55_RS24380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K55_RS24385	COG0765	amino acid transport
I6K55_RS24390	COG4215	(ABC) transporter
I6K55_RS24400	COG4221	oxidoreductase activity
I6K55_RS24405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K55_RS24410	COG4608	Belongs to the ABC transporter superfamily
I6K55_RS24415	COG0444	Belongs to the ABC transporter superfamily
I6K55_RS24420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K55_RS24425	COG0601	transmembrane transport
I6K55_RS24430	COG0747	negative chemotaxis
I6K55_RS24455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K55_RS24465	COG0668	transmembrane transport
I6K55_RS24470	COG0583	DNA-binding transcription factor activity
I6K55_RS24480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K55_RS24490	COG3958	Transketolase
I6K55_RS24495	COG3959	Transketolase, thiamine diphosphate binding domain
I6K55_RS24500	COG2390	Transcriptional regulator
I6K55_RS24505	COG5464	transposase or invertase
I6K55_RS24510	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS24515	COG1129	ABC transporter
I6K55_RS24525	COG1879	ABC-type sugar transport system periplasmic component
I6K55_RS24535	COG4771	TonB-dependent receptor
I6K55_RS24540	COG2382	esterase
I6K55_RS24545	COG3251	PFAM MbtH domain protein
I6K55_RS24550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K55_RS24550	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K55_RS24555	COG1120	ATPase activity
I6K55_RS24560	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS24565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K55_RS24575	COG4592	Periplasmic binding protein
I6K55_RS24580	COG1169	isochorismate synthase
I6K55_RS24585	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K55_RS24590	COG3433	isochorismatase activity
I6K55_RS24590	COG1535	isochorismatase
I6K55_RS24595	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS24605	COG1966	Carbon starvation protein
I6K55_RS24610	COG2879	small protein
I6K55_RS24625	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS24630	COG0371	Dehydrogenase
I6K55_RS24635	COG1129	ABC transporter
I6K55_RS24640	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS24670	COG2271	Major facilitator Superfamily
I6K55_RS24675	COG0483	inositol monophosphate 1-phosphatase activity
I6K55_RS24685	COG0402	S-adenosylhomocysteine deaminase activity
I6K55_RS24695	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K55_RS24710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K55_RS24720	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS24725	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K55_RS24730	COG1129	ABC transporter
I6K55_RS24755	COG0436	Aminotransferase
I6K55_RS24760	COG1475	DNA binding
I6K55_RS24765	COG3969	phosphoadenosine phosphosulfate
I6K55_RS24770	COG0583	DNA-binding transcription factor activity
I6K55_RS24775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K55_RS24795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K55_RS24800	COG3719	Belongs to the RNase T2 family
I6K55_RS24805	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K55_RS24825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K55_RS24840	COG0583	DNA-binding transcription factor activity
I6K55_RS24855	COG1686	Belongs to the peptidase S11 family
I6K55_RS24860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K55_RS24865	COG0772	Belongs to the SEDS family
I6K55_RS24870	COG0768	penicillin binding
I6K55_RS24880	COG0799	negative regulation of ribosome biogenesis
I6K55_RS24895	COG1466	dna polymerase III delta subunit
I6K55_RS24910	COG2888	peptidyl-tyrosine sulfation
I6K55_RS24925	COG1126	abc transporter atp-binding protein
I6K55_RS24930	COG0765	amino acid transport
I6K55_RS24935	COG0765	amino acid transport
I6K55_RS24960	COG1702	phosphate starvation-inducible protein PhoH
I6K55_RS24970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K55_RS25010	COG0367	asparagine synthase
I6K55_RS25015	COG0647	UMP catabolic process
I6K55_RS25020	COG1940	carbohydrate kinase activity
I6K55_RS25020	COG1846	Transcriptional regulator
I6K55_RS25025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K55_RS25065	COG0735	belongs to the Fur family
I6K55_RS25080	COG0596	Alpha beta hydrolase
I6K55_RS25090	COG0033	Phosphoglucomutase
I6K55_RS25100	COG0745	RESPONSE REGULATOR receiver
I6K55_RS25105	COG2205	protein histidine kinase activity
I6K55_RS25135	COG0415	Belongs to the DNA photolyase family
I6K55_RS25150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K55_RS25155	COG1984	allophanate hydrolase subunit 2
I6K55_RS25190	COG2009	succinate dehydrogenase
I6K55_RS25195	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K55_RS25200	COG1053	succinate dehydrogenase
I6K55_RS25205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K55_RS25210	COG0567	Dehydrogenase, E1 component
I6K55_RS25215	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K55_RS25225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K55_RS25230	COG1271	oxidase subunit
I6K55_RS25235	COG1294	oxidase, subunit
I6K55_RS25240	COG4890	Cyd operon protein YbgT
I6K55_RS25245	COG3790	cyd operon protein YbgE
I6K55_RS25250	COG0824	Thioesterase
I6K55_RS25255	COG0811	peptide transport
I6K55_RS25260	COG0848	biopolymer transport protein
I6K55_RS25265	COG3064	Membrane
I6K55_RS25275	COG2885	chlorophyll binding
I6K55_RS25280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K55_RS25330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K55_RS25335	COG3201	nicotinamide mononucleotide transporter
I6K55_RS25350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K55_RS25360	COG2017	converts alpha-aldose to the beta-anomer
I6K55_RS25370	COG1085	galactose-1-phosphate uridylyltransferase
I6K55_RS25380	COG1119	ATPase activity
I6K55_RS25385	COG3585	molybdate ion transport
I6K55_RS25385	COG2005	Transcriptional regulator
I6K55_RS25395	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K55_RS25400	COG4149	molybdate abc transporter
I6K55_RS25410	COG0561	phosphatase activity
I6K55_RS25435	COG2200	EAL domain
I6K55_RS25440	COG0789	Transcriptional regulator
I6K55_RS25475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS25480	COG0589	response to stress
I6K55_RS25490	COG4677	pectinesterase activity
I6K55_RS25530	COG1881	PFAM PEBP family protein
I6K55_RS25535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K55_RS25550	COG2226	methyltransferase
I6K55_RS25575	COG0642	Histidine kinase
I6K55_RS25580	COG0745	RESPONSE REGULATOR receiver
I6K55_RS25600	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K55_RS25610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K55_RS25615	COG0314	molybdopterin synthase activity
I6K55_RS25620	COG0670	Belongs to the BI1 family
I6K55_RS25625	COG0392	lysyltransferase activity
I6K55_RS25630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K55_RS25635	COG3568	Endonuclease Exonuclease Phosphatase
I6K55_RS25645	COG0842	Transport permease protein
I6K55_RS25650	COG0842	Transport permease protein
I6K55_RS25655	COG1131	(ABC) transporter
I6K55_RS25660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K55_RS25665	COG1309	transcriptional regulator
I6K55_RS25670	COG0583	DNA-binding transcription factor activity
I6K55_RS25680	COG2271	Major facilitator Superfamily
I6K55_RS25685	COG1028	Short-chain dehydrogenase reductase Sdr
I6K55_RS25690	COG3959	Transketolase, thiamine diphosphate binding domain
I6K55_RS25695	COG3958	Transketolase
I6K55_RS25700	COG0513	Belongs to the DEAD box helicase family
I6K55_RS25705	COG1199	ATP-dependent helicase activity
I6K55_RS25710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K55_RS25720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K55_RS25730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K55_RS25740	COG0668	transmembrane transport
I6K55_RS25745	COG1126	abc transporter atp-binding protein
I6K55_RS25750	COG0765	amino acid transport
I6K55_RS25755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K55_RS25770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K55_RS25775	COG2194	sulfuric ester hydrolase activity
I6K55_RS25790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K55_RS25795	COG2723	6-phospho-beta-galactosidase activity
I6K55_RS25800	COG2188	Transcriptional regulator
I6K55_RS25805	COG1376	ErfK ybiS ycfS ynhG family protein
I6K55_RS25810	COG2365	Tyrosine phosphatase family
I6K55_RS25815	COG0488	(ABC) transporter
I6K55_RS25825	COG2271	Major facilitator Superfamily
I6K55_RS25830	COG1609	Transcriptional regulator
I6K55_RS25840	COG0561	phosphatase activity
I6K55_RS25845	COG1882	Formate acetyltransferase
I6K55_RS25850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K55_RS25855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K55_RS25860	COG0303	'Molybdopterin
I6K55_RS26000	COG3547	Transposase (IS116 IS110 IS902 family)
I6K55_RS26035	COG0431	NADPH-dependent FMN reductase
I6K55_RS26055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K55_RS26060	COG1393	Belongs to the ArsC family
I6K55_RS26065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K55_RS26080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K55_RS26110	COG0589	response to stress
I6K55_RS26115	COG0659	secondary active sulfate transmembrane transporter activity
I6K55_RS26205	COG3344	reverse transcriptase
I6K55_RS26315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K55_RS26320	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K55_RS26325	COG0672	)-iron permease
I6K55_RS26340	COG1136	(ABC) transporter
I6K55_RS26340	COG0577	efflux transmembrane transporter activity
I6K55_RS26345	COG0577	efflux transmembrane transporter activity
I6K55_RS26345	COG1136	(ABC) transporter
I6K55_RS26350	COG1136	(ABC) transporter
I6K55_RS26350	COG0577	efflux transmembrane transporter activity
I6K55_RS26400	COG0459	protein refolding
I6K55_RS26445	COG1136	(ABC) transporter
I6K55_RS26445	COG0577	efflux transmembrane transporter activity
I6K55_RS26450	COG1136	(ABC) transporter
I6K55_RS26450	COG0577	efflux transmembrane transporter activity
I6K55_RS26455	COG1136	(ABC) transporter
I6K55_RS26455	COG0577	efflux transmembrane transporter activity
I6K55_RS26470	COG0672	)-iron permease
I6K55_RS26475	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K55_RS26480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K55_RS26915	COG1106	Psort location Cytoplasmic, score