locus-tag	class	description
I6K60_RS00005	COG0656	L-ascorbic acid biosynthetic process
I6K60_RS00010	COG0583	DNA-binding transcription factor activity
I6K60_RS00015	COG2814	Major facilitator Superfamily
I6K60_RS00025	COG2226	methyltransferase
I6K60_RS00030	COG0741	lytic transglycosylase activity
I6K60_RS00030	COG1388	LysM domain
I6K60_RS00040	COG2226	methyltransferase
I6K60_RS00050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K60_RS00060	COG0583	DNA-binding transcription factor activity
I6K60_RS00070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K60_RS00075	COG1960	acyl-CoA dehydrogenase activity
I6K60_RS00085	COG0121	glutamine amidotransferase
I6K60_RS00090	COG3034	peptidoglycan biosynthetic process
I6K60_RS00105	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K60_RS00110	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K60_RS00125	COG2991	Protein conserved in bacteria
I6K60_RS00140	COG0454	-acetyltransferase
I6K60_RS00145	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K60_RS00165	COG1802	Transcriptional regulator
I6K60_RS00170	COG1113	amino acid transport
I6K60_RS00175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K60_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS00185	COG0579	oxidoreductase
I6K60_RS00200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K60_RS00210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K60_RS00215	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K60_RS00220	COG0022	dehydrogenase e1 component
I6K60_RS00225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K60_RS00235	COG0511	ligase activity, forming carbon-carbon bonds
I6K60_RS00240	COG0439	Biotin carboxylase
I6K60_RS00245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K60_RS00250	COG0697	spore germination
I6K60_RS00265	COG1984	allophanate hydrolase subunit 2
I6K60_RS00270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6K60_RS00275	COG0436	Aminotransferase
I6K60_RS00290	COG4221	oxidoreductase activity
I6K60_RS00300	COG0765	amino acid transport
I6K60_RS00370	COG0791	NLP P60 protein
I6K60_RS00390	COG3639	organic phosphonate transmembrane transporter activity
I6K60_RS00400	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K60_RS00425	COG3188	usher protein
I6K60_RS00440	COG0765	amino acid transport
I6K60_RS00445	COG4597	amino acid ABC transporter
I6K60_RS00450	COG1126	abc transporter atp-binding protein
I6K60_RS00455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS00495	COG4302	ethanolamine ammonia-lyase activity
I6K60_RS00500	COG4303	Ethanolamine ammonia lyase large subunit
I6K60_RS00515	COG0833	amino acid
I6K60_RS00520	COG2040	homocysteine
I6K60_RS00525	COG4521	taurine ABC transporter
I6K60_RS00530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K60_RS00535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K60_RS00540	COG2175	clavaminate synthase activity
I6K60_RS00550	COG1943	Transposase
I6K60_RS00555	COG0113	porphobilinogen synthase activity
I6K60_RS00560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K60_RS00565	COG1335	isochorismatase
I6K60_RS00570	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K60_RS00610	COG1785	Belongs to the alkaline phosphatase family
I6K60_RS00620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K60_RS00630	COG3416	Protein conserved in bacteria
I6K60_RS00635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K60_RS00645	COG4126	flavin adenine dinucleotide binding
I6K60_RS00660	COG1940	carbohydrate kinase activity
I6K60_RS00665	COG0419	ATPase involved in DNA repair
I6K60_RS00670	COG0420	3'-5' exonuclease activity
I6K60_RS00695	COG0366	Alpha amylase catalytic
I6K60_RS00700	COG0583	DNA-binding transcription factor activity
I6K60_RS00705	COG1335	isochorismatase
I6K60_RS00715	COG1228	amidohydrolase
I6K60_RS00725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K60_RS00740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS00745	COG0450	alkyl hydroperoxide reductase
I6K60_RS00770	COG1862	Preprotein translocase
I6K60_RS00775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K60_RS00780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K60_RS00800	COG4238	major outer membrane lipoprotein
I6K60_RS00810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K60_RS00810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K60_RS00830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K60_RS00835	COG0667	Aldo Keto reductase
I6K60_RS00845	COG0142	geranyltranstransferase activity
I6K60_RS00870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K60_RS00880	COG2814	Major facilitator Superfamily
I6K60_RS00885	COG0673	inositol 2-dehydrogenase activity
I6K60_RS00910	COG1053	succinate dehydrogenase
I6K60_RS00915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K60_RS00920	COG1414	Transcriptional regulator
I6K60_RS00935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K60_RS00940	COG1845	cytochrome c oxidase, subunit III
I6K60_RS00945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K60_RS00950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K60_RS00955	COG2223	nitrite transmembrane transporter activity
I6K60_RS00960	COG3056	Lipoprotein
I6K60_RS00965	COG0271	Belongs to the BolA IbaG family
I6K60_RS00985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K60_RS00990	COG0776	regulation of translation
I6K60_RS00995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K60_RS01000	COG1555	photosystem II stabilization
I6K60_RS01005	COG0824	Thioesterase
I6K60_RS01015	COG4533	DNA binding
I6K60_RS01030	COG1522	sequence-specific DNA binding
I6K60_RS01035	COG1132	(ABC) transporter
I6K60_RS01040	COG1132	(ABC) transporter
I6K60_RS01045	COG0347	Belongs to the P(II) protein family
I6K60_RS01050	COG0004	ammonium transporteR
I6K60_RS01055	COG1946	Acyl-CoA thioesterase
I6K60_RS01060	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K60_RS01065	COG3695	enzyme binding
I6K60_RS01095	COG2364	Membrane
I6K60_RS01110	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K60_RS01120	COG2182	Extracellular solute-binding protein
I6K60_RS01125	COG1175	transmembrane transport
I6K60_RS01130	COG3833	ABC-type maltose transport systems, permease component
I6K60_RS01135	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K60_RS01140	COG1874	Beta-galactosidase
I6K60_RS01190	COG0110	maltose O-acetyltransferase activity
I6K60_RS01205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K60_RS01210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS01215	COG1309	transcriptional regulator
I6K60_RS01220	COG3264	Mechanosensitive ion channel
I6K60_RS01220	COG1196	nuclear chromosome segregation
I6K60_RS01225	COG5464	transposase or invertase
I6K60_RS01235	COG3923	Primosomal replication protein n
I6K60_RS01240	COG2832	Protein of unknown function (DUF454)
I6K60_RS01280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K60_RS01285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K60_RS01285	COG4651	solute:proton antiporter activity
I6K60_RS01290	COG2223	nitrite transmembrane transporter activity
I6K60_RS01300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K60_RS01305	COG3735	TraB family
I6K60_RS01320	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K60_RS01325	COG0330	HflC and HflK could
I6K60_RS01330	COG4619	ABC transporter
I6K60_RS01335	COG0390	transport system, permease component
I6K60_RS01340	COG3118	belongs to the thioredoxin family
I6K60_RS01345	COG0300	oxidoreductase activity
I6K60_RS01350	COG2755	lipolytic protein G-D-S-L family
I6K60_RS01355	COG4181	ATPase activity
I6K60_RS01360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K60_RS01380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K60_RS01385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K60_RS01400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K60_RS01410	COG2501	S4 domain
I6K60_RS01440	COG3210	domain, Protein
I6K60_RS01490	COG3539	Fimbrial protein
I6K60_RS01495	COG3121	Chaperone
I6K60_RS01500	COG3188	usher protein
I6K60_RS01515	COG1560	Kdo2-lipid A biosynthetic process
I6K60_RS01525	COG3710	Transcriptional regulator
I6K60_RS01530	COG0531	amino acid
I6K60_RS01535	COG1982	Orn Lys Arg decarboxylase major
I6K60_RS01540	COG3104	oligopeptide transport
I6K60_RS01570	COG0673	inositol 2-dehydrogenase activity
I6K60_RS01585	COG1129	ABC transporter
I6K60_RS01590	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS01635	COG1566	PFAM secretion protein HlyD family protein
I6K60_RS01640	COG1120	ATPase activity
I6K60_RS01645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS01675	COG1473	amidohydrolase
I6K60_RS01680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS01685	COG0667	Aldo Keto reductase
I6K60_RS01730	COG0531	amino acid
I6K60_RS01740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K60_RS01745	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS01760	COG1113	amino acid transport
I6K60_RS01765	COG2211	Major facilitator Superfamily
I6K60_RS01775	COG0673	inositol 2-dehydrogenase activity
I6K60_RS01785	COG2771	luxR family
I6K60_RS01800	COG3188	usher protein
I6K60_RS01830	COG0668	transmembrane transport
I6K60_RS01835	COG0477	Major facilitator Superfamily
I6K60_RS01850	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K60_RS01850	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K60_RS01855	COG2222	sugar isomerase
I6K60_RS01860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K60_RS01865	COG3716	PTS system mannose fructose sorbose family IID component
I6K60_RS01875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS01885	COG0778	Nitroreductase
I6K60_RS01890	COG2315	Protein conserved in bacteria
I6K60_RS01930	COG3698	Phosphodiester glycosidase
I6K60_RS01940	COG4166	transmembrane transport
I6K60_RS01950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K60_RS01955	COG4608	Belongs to the ABC transporter superfamily
I6K60_RS01970	COG0697	spore germination
I6K60_RS01985	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6K60_RS01990	COG0765	amino acid transport
I6K60_RS01995	COG4215	(ABC) transporter
I6K60_RS02005	COG4221	oxidoreductase activity
I6K60_RS02010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K60_RS02015	COG4608	Belongs to the ABC transporter superfamily
I6K60_RS02020	COG0444	Belongs to the ABC transporter superfamily
I6K60_RS02025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K60_RS02030	COG0601	transmembrane transport
I6K60_RS02035	COG0747	negative chemotaxis
I6K60_RS02060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K60_RS02070	COG0668	transmembrane transport
I6K60_RS02075	COG0583	DNA-binding transcription factor activity
I6K60_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS02095	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS02100	COG1129	ABC transporter
I6K60_RS02110	COG1879	ABC-type sugar transport system periplasmic component
I6K60_RS02115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K60_RS02120	COG2390	Transcriptional regulator
I6K60_RS02125	COG3959	Transketolase, thiamine diphosphate binding domain
I6K60_RS02130	COG3958	Transketolase
I6K60_RS02135	COG2977	Belongs to the P-Pant transferase superfamily
I6K60_RS02140	COG4771	TonB-dependent receptor
I6K60_RS02145	COG2382	esterase
I6K60_RS02150	COG3251	PFAM MbtH domain protein
I6K60_RS02155	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K60_RS02155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K60_RS02160	COG1120	ATPase activity
I6K60_RS02165	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS02170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS02180	COG4592	Periplasmic binding protein
I6K60_RS02185	COG1169	isochorismate synthase
I6K60_RS02190	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K60_RS02195	COG3433	isochorismatase activity
I6K60_RS02195	COG1535	isochorismatase
I6K60_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS02210	COG1966	Carbon starvation protein
I6K60_RS02215	COG2879	small protein
I6K60_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS02235	COG0371	Dehydrogenase
I6K60_RS02240	COG1129	ABC transporter
I6K60_RS02245	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS02275	COG2271	Major facilitator Superfamily
I6K60_RS02280	COG0483	inositol monophosphate 1-phosphatase activity
I6K60_RS02290	COG0402	S-adenosylhomocysteine deaminase activity
I6K60_RS02300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K60_RS02315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K60_RS02325	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS02330	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS02335	COG1129	ABC transporter
I6K60_RS02360	COG0436	Aminotransferase
I6K60_RS02365	COG1475	DNA binding
I6K60_RS02370	COG3969	phosphoadenosine phosphosulfate
I6K60_RS02375	COG0583	DNA-binding transcription factor activity
I6K60_RS02380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K60_RS02405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K60_RS02410	COG3719	Belongs to the RNase T2 family
I6K60_RS02415	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K60_RS02435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K60_RS02450	COG0583	DNA-binding transcription factor activity
I6K60_RS02465	COG1686	Belongs to the peptidase S11 family
I6K60_RS02470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K60_RS02475	COG0772	Belongs to the SEDS family
I6K60_RS02480	COG0768	penicillin binding
I6K60_RS02490	COG0799	negative regulation of ribosome biogenesis
I6K60_RS02505	COG1466	dna polymerase III delta subunit
I6K60_RS02520	COG2888	peptidyl-tyrosine sulfation
I6K60_RS02535	COG1126	abc transporter atp-binding protein
I6K60_RS02540	COG0765	amino acid transport
I6K60_RS02545	COG0765	amino acid transport
I6K60_RS02570	COG1702	phosphate starvation-inducible protein PhoH
I6K60_RS02580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K60_RS02620	COG0367	asparagine synthase
I6K60_RS02625	COG0647	UMP catabolic process
I6K60_RS02630	COG1846	Transcriptional regulator
I6K60_RS02630	COG1940	carbohydrate kinase activity
I6K60_RS02635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K60_RS02675	COG0735	belongs to the Fur family
I6K60_RS02690	COG0596	Alpha beta hydrolase
I6K60_RS02700	COG0033	Phosphoglucomutase
I6K60_RS02710	COG0745	RESPONSE REGULATOR receiver
I6K60_RS02715	COG2205	protein histidine kinase activity
I6K60_RS02745	COG0415	Belongs to the DNA photolyase family
I6K60_RS02760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K60_RS02765	COG1984	allophanate hydrolase subunit 2
I6K60_RS02800	COG2009	succinate dehydrogenase
I6K60_RS02805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K60_RS02810	COG1053	succinate dehydrogenase
I6K60_RS02815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K60_RS02820	COG0567	Dehydrogenase, E1 component
I6K60_RS02825	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K60_RS02835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K60_RS02840	COG1271	oxidase subunit
I6K60_RS02845	COG1294	oxidase, subunit
I6K60_RS02850	COG4890	Cyd operon protein YbgT
I6K60_RS02855	COG3790	cyd operon protein YbgE
I6K60_RS02860	COG0824	Thioesterase
I6K60_RS02865	COG0811	peptide transport
I6K60_RS02870	COG0848	biopolymer transport protein
I6K60_RS02875	COG3064	Membrane
I6K60_RS02885	COG2885	chlorophyll binding
I6K60_RS02890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K60_RS02930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K60_RS02935	COG3201	nicotinamide mononucleotide transporter
I6K60_RS02950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K60_RS02960	COG2017	converts alpha-aldose to the beta-anomer
I6K60_RS02970	COG1085	galactose-1-phosphate uridylyltransferase
I6K60_RS02980	COG1119	ATPase activity
I6K60_RS02985	COG2005	Transcriptional regulator
I6K60_RS02985	COG3585	molybdate ion transport
I6K60_RS02995	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K60_RS03000	COG4149	molybdate abc transporter
I6K60_RS03010	COG0561	phosphatase activity
I6K60_RS03035	COG2200	EAL domain
I6K60_RS03040	COG0789	Transcriptional regulator
I6K60_RS03075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS03080	COG0589	response to stress
I6K60_RS03090	COG4677	pectinesterase activity
I6K60_RS03130	COG1881	PFAM PEBP family protein
I6K60_RS03135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K60_RS03150	COG2226	methyltransferase
I6K60_RS03175	COG0642	Histidine kinase
I6K60_RS03180	COG0745	RESPONSE REGULATOR receiver
I6K60_RS03200	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K60_RS03210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K60_RS03215	COG0314	molybdopterin synthase activity
I6K60_RS03220	COG0670	Belongs to the BI1 family
I6K60_RS03225	COG0392	lysyltransferase activity
I6K60_RS03230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K60_RS03235	COG3568	Endonuclease Exonuclease Phosphatase
I6K60_RS03245	COG0842	Transport permease protein
I6K60_RS03250	COG0842	Transport permease protein
I6K60_RS03255	COG1131	(ABC) transporter
I6K60_RS03260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS03265	COG1309	transcriptional regulator
I6K60_RS03270	COG0583	DNA-binding transcription factor activity
I6K60_RS03280	COG2271	Major facilitator Superfamily
I6K60_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS03290	COG3959	Transketolase, thiamine diphosphate binding domain
I6K60_RS03295	COG3958	Transketolase
I6K60_RS03300	COG0513	Belongs to the DEAD box helicase family
I6K60_RS03305	COG1199	ATP-dependent helicase activity
I6K60_RS03310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K60_RS03320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K60_RS03330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K60_RS03340	COG0668	transmembrane transport
I6K60_RS03345	COG1126	abc transporter atp-binding protein
I6K60_RS03350	COG0765	amino acid transport
I6K60_RS03355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS03370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K60_RS03375	COG2194	sulfuric ester hydrolase activity
I6K60_RS03390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K60_RS03395	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS03400	COG2188	Transcriptional regulator
I6K60_RS03405	COG1376	ErfK ybiS ycfS ynhG family protein
I6K60_RS03410	COG2365	Tyrosine phosphatase family
I6K60_RS03415	COG0488	(ABC) transporter
I6K60_RS03425	COG2271	Major facilitator Superfamily
I6K60_RS03430	COG1609	Transcriptional regulator
I6K60_RS03440	COG0561	phosphatase activity
I6K60_RS03445	COG1882	Formate acetyltransferase
I6K60_RS03450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K60_RS03455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K60_RS03460	COG0303	'Molybdopterin
I6K60_RS03475	COG0747	negative chemotaxis
I6K60_RS03495	COG2223	nitrite transmembrane transporter activity
I6K60_RS03505	COG2133	pyrroloquinoline quinone binding
I6K60_RS03510	COG0625	glutathione transferase activity
I6K60_RS03525	COG1686	Belongs to the peptidase S11 family
I6K60_RS03530	COG1349	DNA-binding transcription factor activity
I6K60_RS03535	COG0671	phosphoesterase, PA-phosphatase related
I6K60_RS03540	COG2814	Major facilitator Superfamily
I6K60_RS03545	COG0561	phosphatase activity
I6K60_RS03550	COG0738	Major facilitator superfamily
I6K60_RS03555	COG3226	Transcriptional regulator
I6K60_RS03580	COG0778	Nitroreductase
I6K60_RS03595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K60_RS03600	COG3842	ATPase activity
I6K60_RS03605	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K60_RS03610	COG1177	transmembrane transport
I6K60_RS03625	COG0745	RESPONSE REGULATOR receiver
I6K60_RS03630	COG5002	protein histidine kinase activity
I6K60_RS03635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS03640	COG4160	amino acid transport
I6K60_RS03645	COG4215	(ABC) transporter
I6K60_RS03650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS03655	COG1126	abc transporter atp-binding protein
I6K60_RS03665	COG2203	Gaf domain
I6K60_RS03665	COG3706	GGDEF domain
I6K60_RS03665	COG4251	negative regulation of phosphorylation
I6K60_RS03665	COG5001	Diguanylate cyclase
I6K60_RS03670	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K60_RS03675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K60_RS03680	COG0702	epimerase
I6K60_RS03685	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K60_RS03690	COG0028	Belongs to the TPP enzyme family
I6K60_RS03700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K60_RS03710	COG2431	L-lysine efflux transmembrane transporter activity
I6K60_RS03720	COG3593	DNA synthesis involved in DNA repair
I6K60_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS03735	COG1278	Cold shock
I6K60_RS03745	COG0542	response to heat
I6K60_RS03760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K60_RS03765	COG4988	ABC transporter
I6K60_RS03770	COG0492	ferredoxin-NADP+ reductase activity
I6K60_RS03780	COG1178	ABC-type Fe3 transport system permease component
I6K60_RS03780	COG1674	ftsk spoiiie
I6K60_RS03790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K60_RS03800	COG0243	molybdopterin cofactor binding
I6K60_RS03805	COG0437	4 iron, 4 sulfur cluster binding
I6K60_RS03810	COG3302	dmso reductase anchor subunit
I6K60_RS03815	COG0477	Major facilitator Superfamily
I6K60_RS03820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K60_RS03825	COG1882	Formate acetyltransferase
I6K60_RS03830	COG2116	formate transmembrane transporter activity
I6K60_RS03835	COG1944	ATP diphosphatase activity
I6K60_RS03840	COG2323	membrane
I6K60_RS03860	COG0539	negative regulation of cytoplasmic translation
I6K60_RS03870	COG0658	competence protein
I6K60_RS03870	COG2333	competence protein COMEC
I6K60_RS03885	COG3214	Protein conserved in bacteria
I6K60_RS03900	COG3173	Aminoglycoside phosphotransferase
I6K60_RS03905	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K60_RS03910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K60_RS03920	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K60_RS03930	COG2989	Protein conserved in bacteria
I6K60_RS03935	COG3108	Peptidase M15
I6K60_RS03940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K60_RS03945	COG1448	Aminotransferase
I6K60_RS03950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K60_RS03970	COG0814	amino acid
I6K60_RS03980	COG1473	amidohydrolase
I6K60_RS03990	COG0308	aminopeptidase N
I6K60_RS04000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K60_RS04005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K60_RS04010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K60_RS04015	COG0431	NADPH-dependent FMN reductase
I6K60_RS04030	COG3217	Mosc domain protein beta barrel domain protein
I6K60_RS04030	COG0633	Ferredoxin
I6K60_RS04040	COG0488	(ABC) transporter
I6K60_RS04045	COG2995	paraquat-inducible protein a
I6K60_RS04050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K60_RS04050	COG3008	intermembrane lipid transfer
I6K60_RS04055	COG3009	Protein conserved in bacteria
I6K60_RS04060	COG3130	regulation of translation
I6K60_RS04070	COG1067	ATP-dependent peptidase activity
I6K60_RS04090	COG3070	regulator of competence-specific genes
I6K60_RS04095	COG1289	transmembrane transporter activity
I6K60_RS04100	COG3304	Inner membrane component domain
I6K60_RS04105	COG0210	DNA helicase
I6K60_RS04115	COG1832	CoA-binding protein
I6K60_RS04130	COG1881	PFAM PEBP family protein
I6K60_RS04135	COG2207	Transcriptional regulator
I6K60_RS04150	COG0670	Belongs to the BI1 family
I6K60_RS04175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K60_RS04180	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS04185	COG4638	Rieske (2fe-2S)
I6K60_RS04195	COG0473	3-isopropylmalate dehydrogenase activity
I6K60_RS04200	COG0583	DNA-binding transcription factor activity
I6K60_RS04205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K60_RS04210	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS04215	COG1396	sequence-specific DNA binding
I6K60_RS04215	COG1917	Cupin 2, conserved barrel domain protein
I6K60_RS04220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K60_RS04225	COG0174	glutamine synthetase
I6K60_RS04230	COG0531	amino acid
I6K60_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS04300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K60_RS04330	COG4695	Portal protein
I6K60_RS04490	COG3729	General stress protein
I6K60_RS04500	COG2233	PERMEase
I6K60_RS04535	COG1309	transcriptional regulator
I6K60_RS04550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K60_RS04560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K60_RS04580	COG1702	phosphate starvation-inducible protein PhoH
I6K60_RS04590	COG1335	isochorismatase
I6K60_RS04600	COG0583	DNA-binding transcription factor activity
I6K60_RS04605	COG1309	transcriptional regulator
I6K60_RS04640	COG3381	protein complex oligomerization
I6K60_RS04675	COG5645	(Lipo)protein
I6K60_RS04690	COG1560	Kdo2-lipid A biosynthetic process
I6K60_RS04735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K60_RS04755	COG2814	Major facilitator Superfamily
I6K60_RS04760	COG0583	DNA-binding transcription factor activity
I6K60_RS04765	COG1530	ribonuclease E activity
I6K60_RS04785	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K60_RS04805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K60_RS04820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K60_RS04825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K60_RS04830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K60_RS04840	COG0470	DNA polymerase III
I6K60_RS04845	COG0084	hydrolase, TatD family'
I6K60_RS04855	COG0537	adenosine 5'-monophosphoramidase activity
I6K60_RS04860	COG5633	Lipoprotein
I6K60_RS04885	COG1252	NADH dehydrogenase
I6K60_RS04890	COG3134	Outer membrane lipoprotein
I6K60_RS04905	COG1309	transcriptional regulator
I6K60_RS04920	COG1388	LysM domain
I6K60_RS04920	COG1376	ErfK ybiS ycfS ynhG family protein
I6K60_RS04925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K60_RS04935	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K60_RS04945	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K60_RS04955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K60_RS04965	COG2390	Transcriptional regulator
I6K60_RS04980	COG3395	kinase activity
I6K60_RS04995	COG0698	ribose 5-phosphate isomerase
I6K60_RS05000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K60_RS05005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K60_RS05010	COG0318	PFAM AMP-dependent synthetase and ligase
I6K60_RS05025	COG1177	transmembrane transport
I6K60_RS05045	COG2850	peptidyl-arginine hydroxylation
I6K60_RS05050	COG2205	protein histidine kinase activity
I6K60_RS05070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K60_RS05090	COG1187	pseudouridine synthase activity
I6K60_RS05095	COG0538	isocitrate dehydrogenase activity
I6K60_RS05100	COG0640	Transcriptional regulator
I6K60_RS05120	COG3813	Protein conserved in bacteria
I6K60_RS05125	COG1063	alcohol dehydrogenase
I6K60_RS05130	COG3729	General stress protein
I6K60_RS05135	COG3685	Protein conserved in bacteria
I6K60_RS05140	COG3685	Protein conserved in bacteria
I6K60_RS05145	COG3546	catalase activity
I6K60_RS05150	COG1271	oxidase subunit
I6K60_RS05155	COG1294	oxidase, subunit
I6K60_RS05185	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K60_RS05190	COG0583	DNA-binding transcription factor activity
I6K60_RS05195	COG3706	GGDEF domain
I6K60_RS05200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6K60_RS05210	COG1560	Kdo2-lipid A biosynthetic process
I6K60_RS05220	COG3182	Iron-regulated membrane protein
I6K60_RS05240	COG2203	Gaf domain
I6K60_RS05240	COG2199	diguanylate cyclase activity
I6K60_RS05245	COG2801	Transposase and inactivated derivatives
I6K60_RS05270	COG3042	response to heat
I6K60_RS05275	COG3189	MarR family transcriptional regulator
I6K60_RS05280	COG1683	Conserved Protein
I6K60_RS05285	COG0504	CTP synthase activity
I6K60_RS05290	COG2807	transmembrane transport
I6K60_RS05295	COG2207	Transcriptional regulator
I6K60_RS05305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K60_RS05310	COG0859	PFAM glycosyl transferase family 9
I6K60_RS05320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K60_RS05325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K60_RS05330	COG0583	DNA-binding transcription factor activity
I6K60_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS05360	COG0386	Belongs to the glutathione peroxidase family
I6K60_RS05375	COG2766	serine protein kinase
I6K60_RS05380	COG3713	MltA-interacting MipA family protein
I6K60_RS05385	COG0656	L-ascorbic acid biosynthetic process
I6K60_RS05405	COG3139	Protein of unknown function (DUF1315)
I6K60_RS05420	COG1335	isochorismatase
I6K60_RS05425	COG0252	asparaginase activity
I6K60_RS05430	COG0616	signal peptide processing
I6K60_RS05435	COG0778	Nitroreductase
I6K60_RS05445	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K60_RS05450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K60_RS05455	COG3321	synthase
I6K60_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS05455	COG0604	alcohol dehydrogenase
I6K60_RS05460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K60_RS05465	COG0494	nUDIX hydrolase
I6K60_RS05470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K60_RS05475	COG2897	thiosulfate sulfurtransferase activity
I6K60_RS05480	COG4136	ATPase activity
I6K60_RS05485	COG4135	transport system, permease component
I6K60_RS05490	COG4134	Bacterial extracellular solute-binding protein
I6K60_RS05495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K60_RS05500	COG0398	Pfam SNARE associated Golgi protein
I6K60_RS05505	COG0398	Pfam SNARE associated Golgi protein
I6K60_RS05510	COG0708	Exodeoxyribonuclease III
I6K60_RS05520	COG3138	arginine N-succinyltransferase
I6K60_RS05530	COG3724	N-succinylarginine dihydrolase activity
I6K60_RS05540	COG3678	ATP-independent chaperone mediated protein folding
I6K60_RS05545	COG0322	excinuclease ABC activity
I6K60_RS05555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K60_RS05560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS05570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS05575	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K60_RS05580	COG1917	Cupin 2, conserved barrel domain protein
I6K60_RS05580	COG2169	Transcriptional regulator
I6K60_RS05585	COG1486	melibiose metabolic process
I6K60_RS05595	COG0753	catalase activity
I6K60_RS05605	COG1823	symporter activity
I6K60_RS05610	COG1988	membrane-bound metal-dependent
I6K60_RS05615	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS05620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K60_RS05650	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K60_RS05655	COG3047	cAMP biosynthetic process
I6K60_RS05665	COG4774	siderophore transport
I6K60_RS05720	COG0134	indole-3-glycerol-phosphate synthase activity
I6K60_RS05720	COG0135	phosphoribosylanthranilate isomerase activity
I6K60_RS05725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K60_RS05725	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K60_RS05730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K60_RS05740	COG0009	L-threonylcarbamoyladenylate synthase
I6K60_RS05750	COG0583	DNA-binding transcription factor activity
I6K60_RS05760	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K60_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS05775	COG0616	signal peptide processing
I6K60_RS05800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K60_RS05810	COG0671	phosphoesterase, PA-phosphatase related
I6K60_RS05815	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K60_RS05820	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K60_RS05830	COG0023	Translation Initiation Factor
I6K60_RS05840	COG1349	DNA-binding transcription factor activity
I6K60_RS05855	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K60_RS05855	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K60_RS05860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K60_RS05870	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K60_RS05885	COG4171	peptide transport system, permease
I6K60_RS05900	COG0702	epimerase
I6K60_RS05915	COG1473	amidohydrolase
I6K60_RS05925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K60_RS05930	COG1842	Phage shock protein A
I6K60_RS05940	COG1983	PspC domain protein
I6K60_RS05950	COG3106	COG3106 Predicted ATPase
I6K60_RS05960	COG0583	DNA-binding transcription factor activity
I6K60_RS05965	COG1486	melibiose metabolic process
I6K60_RS05975	COG3180	Ammonia monooxygenase
I6K60_RS05980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K60_RS05985	COG4948	Mandelate Racemase Muconate Lactonizing
I6K60_RS05990	COG2866	Carboxypeptidase
I6K60_RS06000	COG4166	transmembrane transport
I6K60_RS06025	COG0656	L-ascorbic acid biosynthetic process
I6K60_RS06045	COG0583	DNA-binding transcription factor activity
I6K60_RS06050	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS06055	COG1078	dGTPase activity
I6K60_RS06060	COG0693	protein deglycase activity
I6K60_RS06085	COG2885	chlorophyll binding
I6K60_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS06185	COG1309	transcriptional regulator
I6K60_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS06210	COG0583	DNA-binding transcription factor activity
I6K60_RS06240	COG0604	alcohol dehydrogenase
I6K60_RS06245	COG0436	Aminotransferase
I6K60_RS06260	COG2011	ABC-type metal ion transport system permease component
I6K60_RS06275	COG0673	inositol 2-dehydrogenase activity
I6K60_RS06280	COG1349	DNA-binding transcription factor activity
I6K60_RS06290	COG0513	Belongs to the DEAD box helicase family
I6K60_RS06300	COG0589	response to stress
I6K60_RS06310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K60_RS06315	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K60_RS06315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K60_RS06315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K60_RS06315	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K60_RS06320	COG3042	response to heat
I6K60_RS06325	COG3187	Heat shock protein
I6K60_RS06330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K60_RS06335	COG0586	Pfam SNARE associated Golgi protein
I6K60_RS06340	COG2911	Protein conserved in bacteria
I6K60_RS06350	COG3784	Protein of unknown function (DUF1318)
I6K60_RS06355	COG2207	Transcriptional regulator
I6K60_RS06360	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS06375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS06385	COG1126	abc transporter atp-binding protein
I6K60_RS06390	COG0583	DNA-binding transcription factor activity
I6K60_RS06395	COG2072	flavoprotein involved in K transport
I6K60_RS06430	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS06430	COG2030	dehydratase
I6K60_RS06435	COG3396	Phenylacetate-CoA oxygenase
I6K60_RS06440	COG3460	Phenylacetate-CoA oxygenase
I6K60_RS06445	COG3396	Phenylacetate-CoA oxygenase
I6K60_RS06450	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K60_RS06455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K60_RS06460	COG1024	Enoyl-CoA hydratase
I6K60_RS06465	COG1024	Enoyl-CoA hydratase
I6K60_RS06470	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K60_RS06475	COG2050	protein possibly involved in aromatic compounds catabolism
I6K60_RS06485	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K60_RS06490	COG3327	negative regulation of DNA-templated transcription, initiation
I6K60_RS06495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K60_RS06510	COG1643	Atp-dependent helicase
I6K60_RS06515	COG4122	O-methyltransferase activity
I6K60_RS06540	COG0583	DNA-binding transcription factor activity
I6K60_RS06545	COG0667	Aldo Keto reductase
I6K60_RS06550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K60_RS06560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K60_RS06565	COG3138	arginine N-succinyltransferase
I6K60_RS06570	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS06575	COG3724	N-succinylarginine dihydrolase activity
I6K60_RS06580	COG2988	succinylglutamate desuccinylase activity
I6K60_RS06585	COG1113	amino acid transport
I6K60_RS06595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K60_RS06605	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS06610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K60_RS06615	COG0401	homolog of Blt101
I6K60_RS06620	COG5562	phage envelope protein
I6K60_RS06625	COG0425	Belongs to the sulfur carrier protein TusA family
I6K60_RS06630	COG2391	methyltransferase activity
I6K60_RS06655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K60_RS06660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS06660	COG1263	PTS System
I6K60_RS06665	COG1609	Transcriptional regulator
I6K60_RS06670	COG5339	Protein conserved in bacteria
I6K60_RS06675	COG1482	cell wall glycoprotein biosynthetic process
I6K60_RS06680	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K60_RS06680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K60_RS06690	COG0114	fumarate hydratase activity
I6K60_RS06700	COG2205	protein histidine kinase activity
I6K60_RS06710	COG0745	RESPONSE REGULATOR receiver
I6K60_RS06715	COG3136	membrane protein required for alginate biosynthesis
I6K60_RS06725	COG0531	amino acid
I6K60_RS06740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K60_RS06745	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K60_RS06760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K60_RS06775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K60_RS06780	COG1473	amidohydrolase
I6K60_RS06790	COG0583	DNA-binding transcription factor activity
I6K60_RS06795	COG2840	Smr protein MutS2
I6K60_RS06800	COG1414	Transcriptional regulator
I6K60_RS06810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K60_RS06815	COG0183	Belongs to the thiolase family
I6K60_RS06825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K60_RS06830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K60_RS06840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K60_RS06840	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K60_RS06860	COG4565	transcriptional regulatory protein
I6K60_RS06865	COG3290	protein histidine kinase activity
I6K60_RS06890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K60_RS06900	COG0679	Auxin Efflux Carrier
I6K60_RS06930	COG0628	permease
I6K60_RS06950	COG3591	Belongs to the peptidase S1B family
I6K60_RS06960	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6K60_RS06965	COG2814	Major facilitator Superfamily
I6K60_RS06970	COG0583	DNA-binding transcription factor activity
I6K60_RS06975	COG1940	carbohydrate kinase activity
I6K60_RS06980	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K60_RS06995	COG3302	dmso reductase anchor subunit
I6K60_RS07000	COG0437	4 iron, 4 sulfur cluster binding
I6K60_RS07005	COG0243	molybdopterin cofactor binding
I6K60_RS07020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K60_RS07035	COG2271	Major facilitator Superfamily
I6K60_RS07040	COG0246	Mannitol dehydrogenase
I6K60_RS07045	COG0589	response to stress
I6K60_RS07050	COG1802	Transcriptional regulator
I6K60_RS07055	COG4221	oxidoreductase activity
I6K60_RS07070	COG2207	Transcriptional regulator
I6K60_RS07075	COG2135	peptidase activity
I6K60_RS07105	COG0071	Belongs to the small heat shock protein (HSP20) family
I6K60_RS07110	COG1546	Belongs to the CinA family
I6K60_RS07115	COG2200	EAL domain
I6K60_RS07130	COG2207	Transcriptional regulator
I6K60_RS07130	COG3708	Transcriptional regulator
I6K60_RS07135	COG2610	gluconate transmembrane transporter activity
I6K60_RS07140	COG3622	Belongs to the hyi family
I6K60_RS07145	COG0235	Class ii aldolase
I6K60_RS07150	COG3395	kinase activity
I6K60_RS07155	COG2084	Dehydrogenase
I6K60_RS07160	COG1349	DNA-binding transcription factor activity
I6K60_RS07175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K60_RS07180	COG2223	nitrite transmembrane transporter activity
I6K60_RS07215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K60_RS07220	COG0683	leucine binding
I6K60_RS07250	COG2814	Major facilitator Superfamily
I6K60_RS07255	COG0697	spore germination
I6K60_RS07265	COG4977	sequence-specific DNA binding
I6K60_RS07295	COG2271	Major facilitator Superfamily
I6K60_RS07300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K60_RS07305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K60_RS07315	COG3395	kinase activity
I6K60_RS07320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K60_RS07325	COG1349	DNA-binding transcription factor activity
I6K60_RS07330	COG0039	L-malate dehydrogenase activity
I6K60_RS07340	COG0583	DNA-binding transcription factor activity
I6K60_RS07345	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS07360	COG2199	diguanylate cyclase activity
I6K60_RS07410	COG0477	Major facilitator Superfamily
I6K60_RS07420	COG2070	2-Nitropropane dioxygenase
I6K60_RS07425	COG2011	ABC-type metal ion transport system permease component
I6K60_RS07445	COG4628	conserved protein (DUF2132)
I6K60_RS07460	COG2207	Transcriptional regulator
I6K60_RS07490	COG2233	PERMEase
I6K60_RS07495	COG3195	allantoin biosynthetic process
I6K60_RS07495	COG3648	Uricase
I6K60_RS07500	COG2351	hydroxyisourate hydrolase activity
I6K60_RS07505	COG1396	sequence-specific DNA binding
I6K60_RS07510	COG3550	peptidyl-serine autophosphorylation
I6K60_RS07515	COG1649	PFAM Uncharacterised BCR, COG1649
I6K60_RS07525	COG3188	usher protein
I6K60_RS07560	COG3300	MHYT domain
I6K60_RS07560	COG5001	Diguanylate cyclase
I6K60_RS07565	COG2819	hydrolase of the alpha beta superfamily
I6K60_RS07580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS07580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS07585	COG2814	Major facilitator Superfamily
I6K60_RS07595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS07595	COG1263	PTS System
I6K60_RS07600	COG2186	Transcriptional regulator
I6K60_RS07620	COG3835	regulator
I6K60_RS07625	COG1929	Belongs to the glycerate kinase type-1 family
I6K60_RS07680	COG2315	Protein conserved in bacteria
I6K60_RS07685	COG0583	DNA-binding transcription factor activity
I6K60_RS07715	COG0667	Aldo Keto reductase
I6K60_RS07720	COG3386	PFAM SMP-30 Gluconolaconase
I6K60_RS07725	COG0667	Aldo Keto reductase
I6K60_RS07730	COG0667	Aldo Keto reductase
I6K60_RS07740	COG0456	acetyltransferase
I6K60_RS07740	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K60_RS07765	COG1652	LysM domain
I6K60_RS07795	COG1609	Transcriptional regulator
I6K60_RS07805	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS07820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K60_RS07830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K60_RS07835	COG0583	DNA-binding transcription factor activity
I6K60_RS07840	COG0583	DNA-binding transcription factor activity
I6K60_RS07855	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K60_RS07855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K60_RS07855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K60_RS07860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K60_RS07870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K60_RS07875	COG3037	sugar-specific permease SgaT UlaA
I6K60_RS07885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS07890	COG1609	Transcriptional regulator
I6K60_RS07900	COG2223	nitrite transmembrane transporter activity
I6K60_RS07945	COG0477	Major facilitator Superfamily
I6K60_RS07950	COG4529	Protein conserved in bacteria
I6K60_RS07955	COG1902	pentaerythritol trinitrate reductase activity
I6K60_RS07965	COG0583	DNA-binding transcription factor activity
I6K60_RS07970	COG2070	2-Nitropropane dioxygenase
I6K60_RS07980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K60_RS07990	COG0765	amino acid transport
I6K60_RS08070	COG2207	Transcriptional regulator
I6K60_RS08080	COG1280	lysine exporter protein (LysE YggA)
I6K60_RS08085	COG0406	alpha-ribazole phosphatase activity
I6K60_RS08125	COG1953	Uracil, thiamine, allantoin
I6K60_RS08130	COG0402	S-adenosylhomocysteine deaminase activity
I6K60_RS08135	COG3706	GGDEF domain
I6K60_RS08140	COG1609	Transcriptional regulator
I6K60_RS08150	COG0673	inositol 2-dehydrogenase activity
I6K60_RS08165	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K60_RS08170	COG1116	anion transmembrane transporter activity
I6K60_RS08175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K60_RS08180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K60_RS08185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K60_RS08190	COG0076	glutamate decarboxylase activity
I6K60_RS08205	COG2205	protein histidine kinase activity
I6K60_RS08255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K60_RS08255	COG0519	Catalyzes the synthesis of GMP from XMP
I6K60_RS08275	COG0583	DNA-binding transcription factor activity
I6K60_RS08285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K60_RS08290	COG1285	pathogenesis
I6K60_RS08295	COG2814	Major facilitator Superfamily
I6K60_RS08300	COG0583	DNA-binding transcription factor activity
I6K60_RS08305	COG0243	molybdopterin cofactor binding
I6K60_RS08310	COG3781	membrane
I6K60_RS08335	COG1764	response to oxidative stress
I6K60_RS08345	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K60_RS08355	COG2323	membrane
I6K60_RS08365	COG0366	Alpha amylase catalytic
I6K60_RS08375	COG3685	Protein conserved in bacteria
I6K60_RS08385	COG3729	General stress protein
I6K60_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS08435	COG0488	(ABC) transporter
I6K60_RS08450	COG1064	alcohol dehydrogenase
I6K60_RS08455	COG0747	negative chemotaxis
I6K60_RS08465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K60_RS08475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K60_RS08485	COG2814	Major facilitator Superfamily
I6K60_RS08495	COG2326	polyphosphate kinase activity
I6K60_RS08510	COG2864	formate dehydrogenase
I6K60_RS08515	COG0437	4 iron, 4 sulfur cluster binding
I6K60_RS08540	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K60_RS08550	COG3485	protocatechuate 3,4-dioxygenase
I6K60_RS08555	COG4829	muconolactone delta-isomerase
I6K60_RS08560	COG4948	Mandelate Racemase Muconate Lactonizing
I6K60_RS08565	COG1414	Transcriptional regulator
I6K60_RS08585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K60_RS08590	COG1140	nitrate reductase beta subunit
I6K60_RS08595	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K60_RS08600	COG2181	nitrate reductase activity
I6K60_RS08605	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K60_RS08610	COG1178	ABC-type Fe3 transport system permease component
I6K60_RS08615	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K60_RS08620	COG3842	ATPase activity
I6K60_RS08625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K60_RS08635	COG0625	glutathione transferase activity
I6K60_RS08645	COG1126	abc transporter atp-binding protein
I6K60_RS08660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS08665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K60_RS08670	COG1473	amidohydrolase
I6K60_RS08675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K60_RS08680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K60_RS08705	COG4772	TonB-dependent receptor
I6K60_RS08710	COG1228	amidohydrolase
I6K60_RS08715	COG3691	Protein conserved in bacteria
I6K60_RS08725	COG2130	NADP-dependent
I6K60_RS08735	COG1247	-acetyltransferase
I6K60_RS08740	COG3238	Protein conserved in bacteria
I6K60_RS08750	COG0747	negative chemotaxis
I6K60_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS08795	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS08800	COG1177	transmembrane transport
I6K60_RS08805	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K60_RS08810	COG3842	ATPase activity
I6K60_RS08815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K60_RS08820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K60_RS08825	COG1271	oxidase subunit
I6K60_RS08830	COG1294	oxidase, subunit
I6K60_RS08850	COG0826	peptidase U32
I6K60_RS08860	COG1396	sequence-specific DNA binding
I6K60_RS08865	COG3135	benzoate transporter
I6K60_RS08870	COG3708	Transcriptional regulator
I6K60_RS08870	COG2207	Transcriptional regulator
I6K60_RS08885	COG0500	methyltransferase
I6K60_RS08890	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K60_RS08895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K60_RS08900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K60_RS08915	COG2272	Belongs to the type-B carboxylesterase lipase family
I6K60_RS08920	COG5383	Protein conserved in bacteria
I6K60_RS08925	COG3485	protocatechuate 3,4-dioxygenase
I6K60_RS08930	COG3485	protocatechuate 3,4-dioxygenase
I6K60_RS08935	COG0583	DNA-binding transcription factor activity
I6K60_RS08955	COG3038	cytochrome b561
I6K60_RS08975	COG2814	Major facilitator Superfamily
I6K60_RS08995	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS09030	COG4659	FMN binding
I6K60_RS09040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K60_RS09050	COG0625	glutathione transferase activity
I6K60_RS09055	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K60_RS09070	COG3895	Periplasmic Protein
I6K60_RS09085	COG3706	GGDEF domain
I6K60_RS09100	COG1566	PFAM secretion protein HlyD family protein
I6K60_RS09105	COG1289	transmembrane transporter activity
I6K60_RS09110	COG2032	superoxide dismutase activity
I6K60_RS09115	COG4989	oxidoreductase activity
I6K60_RS09120	COG3313	Fe-S protein
I6K60_RS09125	COG1309	transcriptional regulator
I6K60_RS09130	COG1902	pentaerythritol trinitrate reductase activity
I6K60_RS09135	COG0346	lactoylglutathione lyase activity
I6K60_RS09145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K60_RS09150	COG0791	NLP P60 protein
I6K60_RS09165	COG2814	Major facilitator Superfamily
I6K60_RS09180	COG0583	DNA-binding transcription factor activity
I6K60_RS09185	COG2814	Major facilitator Superfamily
I6K60_RS09190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K60_RS09195	COG0307	riboflavin synthase, alpha
I6K60_RS09270	COG3179	chitinase
I6K60_RS09295	COG0300	oxidoreductase activity
I6K60_RS09315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K60_RS09350	COG1349	DNA-binding transcription factor activity
I6K60_RS09355	COG0346	lactoylglutathione lyase activity
I6K60_RS09380	COG0444	Belongs to the ABC transporter superfamily
I6K60_RS09385	COG4608	Belongs to the ABC transporter superfamily
I6K60_RS09415	COG0531	amino acid
I6K60_RS09420	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS09430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K60_RS09465	COG0402	S-adenosylhomocysteine deaminase activity
I6K60_RS09490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K60_RS09495	COG0277	FAD linked oxidase domain protein
I6K60_RS09510	COG2814	Major facilitator Superfamily
I6K60_RS09540	COG0583	DNA-binding transcription factor activity
I6K60_RS09550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K60_RS09560	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K60_RS09565	COG2610	gluconate transmembrane transporter activity
I6K60_RS09570	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS09600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K60_RS09615	COG0745	RESPONSE REGULATOR receiver
I6K60_RS09620	COG5002	protein histidine kinase activity
I6K60_RS09620	COG3850	Histidine kinase
I6K60_RS09640	COG3088	subunit of a heme lyase
I6K60_RS09640	COG4235	cytochrome complex assembly
I6K60_RS09650	COG1138	Cytochrome C-type biogenesis protein
I6K60_RS09665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K60_RS09670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K60_RS09675	COG4133	protoheme IX ABC transporter activity
I6K60_RS09705	COG1175	transmembrane transport
I6K60_RS09715	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K60_RS09720	COG3383	formate dehydrogenase (NAD+) activity
I6K60_RS09760	COG1126	abc transporter atp-binding protein
I6K60_RS09765	COG0765	amino acid transport
I6K60_RS09785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS09790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS09795	COG1120	ATPase activity
I6K60_RS09800	COG4774	siderophore transport
I6K60_RS09805	COG1116	anion transmembrane transporter activity
I6K60_RS09810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K60_RS09830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K60_RS09835	COG0583	DNA-binding transcription factor activity
I6K60_RS09855	COG2814	Major facilitator Superfamily
I6K60_RS09890	COG1414	Transcriptional regulator
I6K60_RS09895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K60_RS09900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS09905	COG1120	ATPase activity
I6K60_RS09915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K60_RS09920	COG2271	Major facilitator Superfamily
I6K60_RS09925	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6K60_RS09925	COG1082	Xylose isomerase domain protein TIM barrel
I6K60_RS09930	COG1309	transcriptional regulator
I6K60_RS09960	COG1376	ErfK ybiS ycfS ynhG family protein
I6K60_RS09975	COG0719	Fe-S assembly protein
I6K60_RS09980	COG0396	ATPase activity
I6K60_RS09985	COG0719	Fe-S assembly protein
I6K60_RS09990	COG0316	Belongs to the HesB IscA family
I6K60_RS10010	COG1309	transcriptional regulator
I6K60_RS10015	COG1304	FMN binding
I6K60_RS10040	COG0583	DNA-binding transcription factor activity
I6K60_RS10050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS10055	COG1120	ATPase activity
I6K60_RS10080	COG2261	transglycosylase associated protein
I6K60_RS10085	COG2050	protein possibly involved in aromatic compounds catabolism
I6K60_RS10090	COG0277	FAD linked oxidase domain protein
I6K60_RS10090	COG0247	lactate metabolic process
I6K60_RS10095	COG0628	permease
I6K60_RS10105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K60_RS10105	COG0574	Belongs to the PEP-utilizing enzyme family
I6K60_RS10120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K60_RS10125	COG4256	Hemin uptake protein
I6K60_RS10135	COG0791	NLP P60 protein
I6K60_RS10145	COG0386	Belongs to the glutathione peroxidase family
I6K60_RS10165	COG0583	DNA-binding transcription factor activity
I6K60_RS10185	COG0072	phenylalanine-tRNA ligase activity
I6K60_RS10185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K60_RS10225	COG3137	Salt-induced outer membrane protein
I6K60_RS10230	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K60_RS10240	COG3001	Fructosamine kinase
I6K60_RS10250	COG2350	Protein conserved in bacteria
I6K60_RS10260	COG2353	YceI-like domain
I6K60_RS10280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K60_RS10290	COG0444	Belongs to the ABC transporter superfamily
I6K60_RS10295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K60_RS10300	COG0601	transmembrane transport
I6K60_RS10305	COG4166	transmembrane transport
I6K60_RS10310	COG2095	MarC family integral membrane protein
I6K60_RS10320	COG1454	alcohol dehydrogenase
I6K60_RS10320	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS10325	COG1435	thymidine kinase activity
I6K60_RS10335	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K60_RS10340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K60_RS10345	COG0745	RESPONSE REGULATOR receiver
I6K60_RS10350	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K60_RS10360	COG0788	formyltetrahydrofolate deformylase activity
I6K60_RS10400	COG1522	sequence-specific DNA binding
I6K60_RS10410	COG2181	nitrate reductase activity
I6K60_RS10415	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K60_RS10420	COG1140	nitrate reductase beta subunit
I6K60_RS10425	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K60_RS10435	COG2223	nitrite transmembrane transporter activity
I6K60_RS10440	COG3850	Histidine kinase
I6K60_RS10445	COG2197	response regulator
I6K60_RS10450	COG4932	domain protein
I6K60_RS10455	COG0243	molybdopterin cofactor binding
I6K60_RS10460	COG2146	nitrite reductase [NAD(P)H] activity
I6K60_RS10460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K60_RS10465	COG1116	anion transmembrane transporter activity
I6K60_RS10475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K60_RS10480	COG3707	response regulator
I6K60_RS10485	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K60_RS10495	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K60_RS10500	COG4572	Cation transport regulator
I6K60_RS10505	COG0387	Pfam Sodium calcium exchanger
I6K60_RS10525	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K60_RS10555	COG0659	secondary active sulfate transmembrane transporter activity
I6K60_RS10575	COG0012	GTP binding
I6K60_RS10680	COG2885	chlorophyll binding
I6K60_RS10700	COG3122	Protein conserved in bacteria
I6K60_RS10715	COG0583	DNA-binding transcription factor activity
I6K60_RS10745	COG0583	DNA-binding transcription factor activity
I6K60_RS10780	COG1882	Formate acetyltransferase
I6K60_RS10795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K60_RS10800	COG0583	DNA-binding transcription factor activity
I6K60_RS10840	COG2308	Evidence 4 Homologs of previously reported genes of
I6K60_RS10855	COG4774	siderophore transport
I6K60_RS10865	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K60_RS10890	COG2719	SpoVR family
I6K60_RS10920	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K60_RS10935	COG2894	cell division
I6K60_RS10945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K60_RS10955	COG3065	identical protein binding
I6K60_RS10965	COG1199	ATP-dependent helicase activity
I6K60_RS10970	COG0251	oxidation-reduction process
I6K60_RS10990	COG1760	l-serine dehydratase
I6K60_RS10995	COG2200	EAL domain
I6K60_RS11000	COG1253	flavin adenine dinucleotide binding
I6K60_RS11005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS11005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS11010	COG3715	PTS system
I6K60_RS11015	COG3716	PTS system mannose fructose sorbose family IID component
I6K60_RS11030	COG2226	methyltransferase
I6K60_RS11035	COG0768	penicillin binding
I6K60_RS11065	COG1414	Transcriptional regulator
I6K60_RS11070	COG2814	Major facilitator Superfamily
I6K60_RS11090	COG1956	GAF domain-containing protein
I6K60_RS11095	COG2995	paraquat-inducible protein a
I6K60_RS11100	COG3008	intermembrane lipid transfer
I6K60_RS11125	COG2990	Protein conserved in bacteria
I6K60_RS11140	COG1276	copper resistance
I6K60_RS11145	COG2372	response to copper ion
I6K60_RS11155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K60_RS11160	COG1770	oligopeptidase
I6K60_RS11165	COG2979	Protein of unknown function (DUF533)
I6K60_RS11170	COG3141	response to X-ray
I6K60_RS11180	COG0800	Aldolase
I6K60_RS11185	COG0129	dihydroxy-acid dehydratase activity
I6K60_RS11190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K60_RS11200	COG1737	Transcriptional regulator
I6K60_RS11210	COG1560	Kdo2-lipid A biosynthetic process
I6K60_RS11215	COG0739	heme binding
I6K60_RS11220	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K60_RS11230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K60_RS11255	COG0494	nUDIX hydrolase
I6K60_RS11265	COG1335	isochorismatase
I6K60_RS11270	COG1801	Protein of unknown function DUF72
I6K60_RS11275	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K60_RS11295	COG3102	Protein conserved in bacteria
I6K60_RS11305	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6K60_RS11330	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS11340	COG1879	ABC-type sugar transport system periplasmic component
I6K60_RS11350	COG1528	Iron-storage protein
I6K60_RS11360	COG2211	Major facilitator Superfamily
I6K60_RS11370	COG0477	Major facilitator Superfamily
I6K60_RS11385	COG1528	Iron-storage protein
I6K60_RS11395	COG0814	amino acid
I6K60_RS11400	COG3012	SEC-C Motif Domain Protein
I6K60_RS11400	COG3318	Belongs to the UPF0149 family
I6K60_RS11435	COG2197	response regulator
I6K60_RS11445	COG2197	response regulator
I6K60_RS11450	COG1126	abc transporter atp-binding protein
I6K60_RS11455	COG0765	amino acid transport
I6K60_RS11465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS11470	COG0366	Alpha amylase catalytic
I6K60_RS11500	COG2354	Protein conserved in bacteria
I6K60_RS11505	COG0697	spore germination
I6K60_RS11510	COG3727	T/G mismatch-specific endonuclease activity
I6K60_RS11515	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K60_RS11520	COG1418	mRNA catabolic process
I6K60_RS11530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K60_RS11580	COG0025	NhaP-type Na H and K H
I6K60_RS11585	COG1309	transcriptional regulator
I6K60_RS11590	COG0604	alcohol dehydrogenase
I6K60_RS11610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K60_RS11620	COG0534	Mate efflux family protein
I6K60_RS11630	COG0582	viral genome integration into host DNA
I6K60_RS11645	COG1737	Transcriptional regulator
I6K60_RS11660	COG2814	Major facilitator Superfamily
I6K60_RS11665	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS11680	COG4977	sequence-specific DNA binding
I6K60_RS11685	COG1566	PFAM secretion protein HlyD family protein
I6K60_RS11700	COG2207	Transcriptional regulator
I6K60_RS11720	COG3706	GGDEF domain
I6K60_RS11745	COG3615	Tellurite resistance protein tehB
I6K60_RS11755	COG3300	MHYT domain
I6K60_RS11755	COG5001	Diguanylate cyclase
I6K60_RS11765	COG0477	Major facilitator Superfamily
I6K60_RS11770	COG0095	Lipoate-protein ligase
I6K60_RS11775	COG0583	DNA-binding transcription factor activity
I6K60_RS11780	COG1942	4-Oxalocrotonate Tautomerase
I6K60_RS11790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K60_RS11810	COG1289	transmembrane transporter activity
I6K60_RS11825	COG2925	Exonuclease
I6K60_RS11830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K60_RS11835	COG0640	Transcriptional regulator
I6K60_RS11840	COG0531	amino acid
I6K60_RS11850	COG0583	DNA-binding transcription factor activity
I6K60_RS11855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K60_RS11885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K60_RS11910	COG0438	transferase activity, transferring glycosyl groups
I6K60_RS12055	COG1253	flavin adenine dinucleotide binding
I6K60_RS12060	COG2982	Protein involved in outer membrane biogenesis
I6K60_RS12075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K60_RS12080	COG0443	Heat shock 70 kDa protein
I6K60_RS12085	COG5002	protein histidine kinase activity
I6K60_RS12105	COG1301	dicarboxylic acid transport
I6K60_RS12130	COG2205	protein histidine kinase activity
I6K60_RS12135	COG0745	RESPONSE REGULATOR receiver
I6K60_RS12140	COG0826	peptidase U32
I6K60_RS12150	COG4608	Belongs to the ABC transporter superfamily
I6K60_RS12155	COG0444	Belongs to the ABC transporter superfamily
I6K60_RS12160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K60_RS12165	COG0601	transmembrane transport
I6K60_RS12175	COG4948	Mandelate Racemase Muconate Lactonizing
I6K60_RS12180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K60_RS12190	COG1070	Carbohydrate kinase
I6K60_RS12225	COG1830	Aldolase
I6K60_RS12230	COG0351	phosphomethylpyrimidine kinase
I6K60_RS12245	COG0583	DNA-binding transcription factor activity
I6K60_RS12255	COG2252	PERMEase
I6K60_RS12260	COG0583	DNA-binding transcription factor activity
I6K60_RS12265	COG5455	response to cobalt ion
I6K60_RS12285	COG4807	Protein conserved in bacteria
I6K60_RS12295	COG3275	phosphorelay sensor kinase activity
I6K60_RS12305	COG1174	glycine betaine transport
I6K60_RS12310	COG1125	glycine betaine transport
I6K60_RS12315	COG1174	glycine betaine transport
I6K60_RS12320	COG1732	Glycine betaine
I6K60_RS12325	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K60_RS12330	COG0277	FAD linked oxidase domain protein
I6K60_RS12345	COG1686	Belongs to the peptidase S11 family
I6K60_RS12355	COG0586	Pfam SNARE associated Golgi protein
I6K60_RS12360	COG1538	Outer membrane efflux protein
I6K60_RS12365	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS12380	COG3659	wide pore channel activity
I6K60_RS12385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K60_RS12395	COG1346	cytolysis
I6K60_RS12405	COG2949	membrane
I6K60_RS12415	COG1129	ABC transporter
I6K60_RS12430	COG2311	Membrane
I6K60_RS12445	COG4771	TonB-dependent receptor
I6K60_RS12450	COG0833	amino acid
I6K60_RS12455	COG0583	DNA-binding transcription factor activity
I6K60_RS12460	COG2855	membrane
I6K60_RS12470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K60_RS12470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K60_RS12470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K60_RS12475	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K60_RS12480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS12480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS12500	COG1312	Catalyzes the dehydration of D-mannonate
I6K60_RS12505	COG0246	Mannitol dehydrogenase
I6K60_RS12510	COG0523	cobalamin synthesis protein
I6K60_RS12515	COG0671	phosphoesterase, PA-phosphatase related
I6K60_RS12520	COG0791	NLP P60 protein
I6K60_RS12525	COG2200	EAL domain
I6K60_RS12530	COG4166	transmembrane transport
I6K60_RS12535	COG4174	ABC transporter (Permease)
I6K60_RS12540	COG4239	(ABC) transporter, permease
I6K60_RS12545	COG4172	Belongs to the ABC transporter superfamily
I6K60_RS12555	COG2814	Major facilitator Superfamily
I6K60_RS12560	COG1187	pseudouridine synthase activity
I6K60_RS12565	COG1061	Type III restriction enzyme res subunit
I6K60_RS12585	COG0494	nUDIX hydrolase
I6K60_RS12590	COG1349	DNA-binding transcription factor activity
I6K60_RS12615	COG0628	permease
I6K60_RS12630	COG0659	secondary active sulfate transmembrane transporter activity
I6K60_RS12635	COG2239	Acts as a magnesium transporter
I6K60_RS12640	COG4615	Cyclic peptide transporter
I6K60_RS12645	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K60_RS12650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K60_RS12650	COG2169	Transcriptional regulator
I6K60_RS12665	COG0642	Histidine kinase
I6K60_RS12665	COG2198	Histidine kinase
I6K60_RS12675	COG0784	Response regulator, receiver
I6K60_RS12675	COG2205	protein histidine kinase activity
I6K60_RS12700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K60_RS12705	COG0584	glycerophosphoryl diester phosphodiesterase
I6K60_RS12710	COG2271	Major facilitator Superfamily
I6K60_RS12715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K60_RS12725	COG0247	lactate metabolic process
I6K60_RS12735	COG2271	Major facilitator Superfamily
I6K60_RS12745	COG1414	Transcriptional regulator
I6K60_RS12760	COG5464	transposase or invertase
I6K60_RS12770	COG0318	PFAM AMP-dependent synthetase and ligase
I6K60_RS12795	COG1169	isochorismate synthase
I6K60_RS12800	COG2153	protein acetylation
I6K60_RS12815	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K60_RS12820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K60_RS12830	COG0839	Belongs to the complex I subunit 6 family
I6K60_RS12875	COG0583	DNA-binding transcription factor activity
I6K60_RS12880	COG0436	Aminotransferase
I6K60_RS12890	COG0490	domain, Protein
I6K60_RS12890	COG0471	metal ion transport
I6K60_RS12895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K60_RS12915	COG0280	phosphate acetyltransferase
I6K60_RS12915	COG0857	belongs to the CobB CobQ family
I6K60_RS12925	COG0622	Phosphoesterase
I6K60_RS12930	COG0625	glutathione transferase activity
I6K60_RS12935	COG0625	glutathione transferase activity
I6K60_RS12940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K60_RS12945	COG1090	epimerase
I6K60_RS12960	COG4598	ABC transporter
I6K60_RS12965	COG4160	amino acid transport
I6K60_RS12990	COG0163	prenyltransferase activity
I6K60_RS12995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K60_RS13000	COG1286	toxin biosynthetic process
I6K60_RS13005	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K60_RS13010	COG0285	dihydrofolate synthase activity
I6K60_RS13020	COG0586	Pfam SNARE associated Golgi protein
I6K60_RS13030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K60_RS13050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K60_RS13065	COG3101	peptidyl-lysine hydroxylation
I6K60_RS13070	COG0730	response to heat
I6K60_RS13095	COG2062	phosphohistidine phosphatase, SixA
I6K60_RS13110	COG3691	Protein conserved in bacteria
I6K60_RS13120	COG2853	Lipoprotein
I6K60_RS13125	COG2116	formate transmembrane transporter activity
I6K60_RS13265	COG2885	chlorophyll binding
I6K60_RS13300	COG0583	DNA-binding transcription factor activity
I6K60_RS13305	COG0590	tRNA wobble adenosine to inosine editing
I6K60_RS13310	COG2807	transmembrane transport
I6K60_RS13320	COG0436	Aminotransferase
I6K60_RS13335	COG3275	phosphorelay sensor kinase activity
I6K60_RS13340	COG3279	Response regulator of the LytR AlgR family
I6K60_RS13355	COG3961	Belongs to the TPP enzyme family
I6K60_RS13360	COG0667	Aldo Keto reductase
I6K60_RS13375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K60_RS13380	COG2199	diguanylate cyclase activity
I6K60_RS13380	COG2200	EAL domain
I6K60_RS13395	COG3415	Transposase
I6K60_RS13400	COG3415	Transposase
I6K60_RS13435	COG0583	DNA-binding transcription factor activity
I6K60_RS13440	COG0385	Bile acid
I6K60_RS13445	COG3530	Putative quorum-sensing-regulated virulence factor
I6K60_RS13465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K60_RS13500	COG4319	ketosteroid isomerase
I6K60_RS13510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K60_RS13515	COG4208	sulfate ABC transporter
I6K60_RS13520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K60_RS13525	COG4150	thiosulfate binding
I6K60_RS13535	COG2837	iron assimilation
I6K60_RS13555	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K60_RS13645	COG4810	utilization protein
I6K60_RS13655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K60_RS13660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K60_RS13665	COG5342	invasion associated locus B
I6K60_RS13675	COG0493	'glutamate synthase
I6K60_RS13675	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K60_RS13680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K60_RS13690	COG1393	Belongs to the ArsC family
I6K60_RS13705	COG0400	carboxylic ester hydrolase activity
I6K60_RS13710	COG1444	tRNA N-acetyltransferase activity
I6K60_RS13715	COG2321	neutral zinc metallopeptidase
I6K60_RS13725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K60_RS13735	COG2716	regulation of RNA biosynthetic process
I6K60_RS13740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K60_RS13745	COG0628	permease
I6K60_RS13755	COG4783	chaperone-mediated protein folding
I6K60_RS13760	COG1393	Belongs to the ArsC family
I6K60_RS13775	COG2233	PERMEase
I6K60_RS13785	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS13800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K60_RS13815	COG2200	EAL domain
I6K60_RS13835	COG0641	radical SAM
I6K60_RS13840	COG3119	arylsulfatase activity
I6K60_RS13850	COG3179	chitinase
I6K60_RS13890	COG3617	BRO family, N-terminal domain
I6K60_RS13995	COG3728	DNA packaging
I6K60_RS13995	COG5484	DNA packaging
I6K60_RS14040	COG3756	Protein conserved in bacteria
I6K60_RS14045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K60_RS14075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K60_RS14120	COG0517	IMP dehydrogenase activity
I6K60_RS14120	COG0516	GMP reductase activity
I6K60_RS14130	COG1645	bacterial-type flagellum-dependent swarming motility
I6K60_RS14160	COG2976	Protein conserved in bacteria
I6K60_RS14190	COG4953	penicillin-binding protein 1C
I6K60_RS14195	COG2373	Large extracellular alpha-helical protein
I6K60_RS14200	COG2897	thiosulfate sulfurtransferase activity
I6K60_RS14225	COG2975	iron-sulfur cluster assembly
I6K60_RS14230	COG0633	Ferredoxin
I6K60_RS14250	COG0822	iron-sulfur transferase activity
I6K60_RS14280	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K60_RS14285	COG3683	transport system, periplasmic component
I6K60_RS14290	COG3711	transcriptional antiterminator
I6K60_RS14295	COG2814	Major facilitator Superfamily
I6K60_RS14300	COG2017	converts alpha-aldose to the beta-anomer
I6K60_RS14305	COG0477	Major facilitator Superfamily
I6K60_RS14305	COG2814	Major facilitator Superfamily
I6K60_RS14310	COG0457	Tetratricopeptide repeat
I6K60_RS14315	COG1940	carbohydrate kinase activity
I6K60_RS14320	COG2259	Doxx family
I6K60_RS14330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K60_RS14330	COG1017	nitric oxide dioxygenase activity
I6K60_RS14335	COG0347	Belongs to the P(II) protein family
I6K60_RS14340	COG2204	response regulator
I6K60_RS14345	COG3170	Tfp pilus assembly protein FimV
I6K60_RS14350	COG2205	protein histidine kinase activity
I6K60_RS14355	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K60_RS14355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K60_RS14370	COG0560	Phosphoserine phosphatase
I6K60_RS14375	COG1737	Transcriptional regulator
I6K60_RS14380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K60_RS14390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K60_RS14410	COG0681	Belongs to the peptidase S26 family
I6K60_RS14420	COG3086	response to oxidative stress
I6K60_RS14425	COG3026	antisigma factor binding
I6K60_RS14430	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K60_RS14445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K60_RS14455	COG0513	Belongs to the DEAD box helicase family
I6K60_RS14470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K60_RS14475	COG3118	belongs to the thioredoxin family
I6K60_RS14480	COG3148	PFAM DTW domain containing protein
I6K60_RS14490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K60_RS14495	COG5544	Lipoprotein
I6K60_RS14500	COG0477	Major facilitator Superfamily
I6K60_RS14525	COG0542	response to heat
I6K60_RS14540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K60_RS14545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K60_RS14555	COG0077	Prephenate dehydratase
I6K60_RS14555	COG1605	Chorismate mutase
I6K60_RS14565	COG1605	Chorismate mutase
I6K60_RS14565	COG0287	Prephenate dehydrogenase
I6K60_RS14570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K60_RS14580	COG2199	diguanylate cyclase activity
I6K60_RS14585	COG2885	chlorophyll binding
I6K60_RS14620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K60_RS14625	COG4137	Cytochrome C assembly protein
I6K60_RS14630	COG4536	flavin adenine dinucleotide binding
I6K60_RS14645	COG0497	DNA recombination
I6K60_RS14660	COG2867	negative regulation of translational initiation
I6K60_RS14685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K60_RS14790	COG0740	serine-type endopeptidase activity
I6K60_RS14795	COG4695	Portal protein
I6K60_RS14800	COG4626	Terminase
I6K60_RS14800	COG1802	Transcriptional regulator
I6K60_RS14845	COG3772	lysozyme
I6K60_RS14860	COG0484	heat shock protein binding
I6K60_RS14870	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K60_RS14880	COG1484	DNA-dependent DNA replication
I6K60_RS14950	COG0582	viral genome integration into host DNA
I6K60_RS14970	COG0582	viral genome integration into host DNA
I6K60_RS14980	COG1204	response to ionizing radiation
I6K60_RS15010	COG4916	TIR domain
I6K60_RS15030	COG2207	Transcriptional regulator
I6K60_RS15030	COG3708	Transcriptional regulator
I6K60_RS15035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS15070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS15080	COG0235	Class ii aldolase
I6K60_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS15125	COG3121	Chaperone
I6K60_RS15130	COG3539	Fimbrial protein
I6K60_RS15140	COG3284	Transcriptional regulator
I6K60_RS15145	COG0583	DNA-binding transcription factor activity
I6K60_RS15155	COG0640	Transcriptional regulator
I6K60_RS15160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K60_RS15175	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K60_RS15190	COG4575	ribosome binding
I6K60_RS15195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K60_RS15200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K60_RS15205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K60_RS15215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K60_RS15230	COG4176	ABC-type proline glycine betaine transport system permease component
I6K60_RS15240	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K60_RS15250	COG1846	Transcriptional regulator
I6K60_RS15255	COG1566	PFAM secretion protein HlyD family protein
I6K60_RS15260	COG2814	Major facilitator Superfamily
I6K60_RS15265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K60_RS15285	COG1238	metal cluster binding
I6K60_RS15290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K60_RS15295	COG2823	Periplasmic or secreted lipoprotein
I6K60_RS15325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K60_RS15345	COG1546	Belongs to the CinA family
I6K60_RS15350	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K60_RS15355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K60_RS15360	COG1121	(ABC) transporter
I6K60_RS15365	COG2951	lytic endotransglycosylase activity
I6K60_RS15370	COG3730	PTS system glucitol sorbitol-specific
I6K60_RS15375	COG3732	PTS system glucitol sorbitol-specific
I6K60_RS15385	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS15390	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS15395	COG1349	DNA-binding transcription factor activity
I6K60_RS15420	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K60_RS15425	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K60_RS15430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K60_RS15435	COG1609	Transcriptional regulator
I6K60_RS15440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS15440	COG1263	PTS System
I6K60_RS15445	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS15455	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K60_RS15465	COG3260	NADH ubiquinone oxidoreductase 20
I6K60_RS15470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K60_RS15475	COG3261	NADH dehydrogenase
I6K60_RS15475	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K60_RS15480	COG0650	Formate hydrogenlyase subunit 4
I6K60_RS15485	COG0651	ATP synthesis coupled electron transport
I6K60_RS15490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K60_RS15505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K60_RS15510	COG0298	carbon dioxide binding
I6K60_RS15515	COG0409	Hydrogenase expression formation protein
I6K60_RS15520	COG0309	Hydrogenase expression formation protein (HypE)
I6K60_RS15530	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS15540	COG4580	involved in the transport of maltose and maltodextrins
I6K60_RS15545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS15550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS15555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS15560	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K60_RS15565	COG1940	carbohydrate kinase activity
I6K60_RS15570	COG1609	Transcriptional regulator
I6K60_RS15580	COG1121	(ABC) transporter
I6K60_RS15585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K60_RS15590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K60_RS15605	COG0679	Auxin Efflux Carrier
I6K60_RS15625	COG3720	iron ion transport
I6K60_RS15630	COG4558	Periplasmic binding protein
I6K60_RS15635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS15675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K60_RS15680	COG0163	prenyltransferase activity
I6K60_RS15705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K60_RS15710	COG1388	LysM domain
I6K60_RS15710	COG4942	peptidase
I6K60_RS15770	COG2234	aminopeptidase activity
I6K60_RS15790	COG0720	synthase
I6K60_RS15795	COG0602	queuosine metabolic process
I6K60_RS15815	COG3956	TIGRFAM MazG family protein
I6K60_RS15820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K60_RS15830	COG3850	Histidine kinase
I6K60_RS15830	COG3437	response regulator, receiver
I6K60_RS15830	COG4999	Histidine kinase
I6K60_RS15830	COG2205	protein histidine kinase activity
I6K60_RS15835	COG1929	Belongs to the glycerate kinase type-1 family
I6K60_RS15840	COG4948	Mandelate Racemase Muconate Lactonizing
I6K60_RS15845	COG4948	Mandelate Racemase Muconate Lactonizing
I6K60_RS15850	COG2271	Major facilitator Superfamily
I6K60_RS15855	COG0716	FMN binding
I6K60_RS15860	COG0564	pseudouridine synthase activity
I6K60_RS15865	COG3098	single-species biofilm formation
I6K60_RS15880	COG1611	Belongs to the LOG family
I6K60_RS15885	COG0814	amino acid
I6K60_RS15890	COG1760	l-serine dehydratase
I6K60_RS15895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K60_RS15905	COG0477	Major facilitator Superfamily
I6K60_RS15910	COG1464	Belongs to the NlpA lipoprotein family
I6K60_RS15915	COG2011	ABC-type metal ion transport system permease component
I6K60_RS15935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K60_RS15955	COG1454	alcohol dehydrogenase
I6K60_RS15960	COG0235	Class ii aldolase
I6K60_RS15985	COG1349	DNA-binding transcription factor activity
I6K60_RS15995	COG2363	Small membrane protein
I6K60_RS16000	COG0583	DNA-binding transcription factor activity
I6K60_RS16010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K60_RS16015	COG2166	iron-sulfur cluster assembly
I6K60_RS16020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K60_RS16025	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K60_RS16055	COG2885	chlorophyll binding
I6K60_RS16280	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K60_RS16310	COG1454	alcohol dehydrogenase
I6K60_RS16310	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS16315	COG4656	Part of a membrane complex involved in electron transport
I6K60_RS16345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K60_RS16350	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K60_RS16355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K60_RS16355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K60_RS16365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K60_RS16370	COG1074	ATP-dependent DNA helicase activity
I6K60_RS16375	COG1025	Belongs to the peptidase M16 family
I6K60_RS16380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K60_RS16385	COG4967	type IV pilus modification protein PilV
I6K60_RS16395	COG4795	General secretion pathway protein
I6K60_RS16400	COG2165	general secretion pathway protein
I6K60_RS16435	COG0861	Integral membrane protein TerC family
I6K60_RS16445	COG0667	Aldo Keto reductase
I6K60_RS16465	COG1609	Transcriptional regulator
I6K60_RS16475	COG2186	Transcriptional regulator
I6K60_RS16480	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS16485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS16490	COG1609	Transcriptional regulator
I6K60_RS16500	COG0583	DNA-binding transcription factor activity
I6K60_RS16505	COG1794	racemase activity, acting on amino acids and derivatives
I6K60_RS16510	COG1917	Cupin 2, conserved barrel domain protein
I6K60_RS16515	COG1175	transmembrane transport
I6K60_RS16520	COG0395	ABC-type sugar transport system, permease component
I6K60_RS16525	COG3842	ATPase activity
I6K60_RS16560	COG2814	Major facilitator Superfamily
I6K60_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS16570	COG0823	Involved in the tonB-independent uptake of proteins
I6K60_RS16580	COG0183	Belongs to the thiolase family
I6K60_RS16595	COG0814	amino acid
I6K60_RS16600	COG0667	Aldo Keto reductase
I6K60_RS16650	COG0697	spore germination
I6K60_RS16655	COG1846	Transcriptional regulator
I6K60_RS16660	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K60_RS16665	COG0582	viral genome integration into host DNA
I6K60_RS16670	COG4974	Belongs to the 'phage' integrase family
I6K60_RS16680	COG3539	Fimbrial protein
I6K60_RS16685	COG3121	Chaperone
I6K60_RS16690	COG3188	usher protein
I6K60_RS16695	COG3539	Fimbrial protein
I6K60_RS16700	COG3539	Fimbrial protein
I6K60_RS16705	COG3539	Fimbrial protein
I6K60_RS16715	COG2388	GCN5-related N-acetyl-transferase
I6K60_RS16720	COG3592	Divergent 4Fe-4S mono-cluster
I6K60_RS16735	COG1289	transmembrane transporter activity
I6K60_RS16740	COG1538	Outer membrane efflux protein
I6K60_RS16755	COG1393	Belongs to the ArsC family
I6K60_RS16760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K60_RS16800	COG0667	Aldo Keto reductase
I6K60_RS16815	COG2814	Major facilitator Superfamily
I6K60_RS16825	COG4942	peptidase
I6K60_RS16845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K60_RS16855	COG4974	Belongs to the 'phage' integrase family
I6K60_RS16860	COG0716	FMN binding
I6K60_RS16870	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K60_RS16880	COG1272	protein, Hemolysin III
I6K60_RS16890	COG1737	Transcriptional regulator
I6K60_RS16895	COG2723	6-phospho-beta-galactosidase activity
I6K60_RS16915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K60_RS16920	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS16940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K60_RS16945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K60_RS16950	COG0006	proline dipeptidase activity
I6K60_RS16970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K60_RS16975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K60_RS16990	COG2968	Membrane
I6K60_RS17000	COG0668	transmembrane transport
I6K60_RS17005	COG0191	fructose-bisphosphate aldolase activity
I6K60_RS17020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K60_RS17025	COG0501	Belongs to the peptidase M48B family
I6K60_RS17060	COG2814	Major facilitator Superfamily
I6K60_RS17070	COG2356	endonuclease I
I6K60_RS17075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K60_RS17100	COG2805	Type II/IV secretion system protein
I6K60_RS17105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K60_RS17110	COG0762	integral membrane protein
I6K60_RS17125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K60_RS17130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K60_RS17135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K60_RS17135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K60_RS17150	COG3171	Protein conserved in bacteria
I6K60_RS17160	COG1194	a g-specific adenine glycosylase
I6K60_RS17175	COG2211	Major facilitator Superfamily
I6K60_RS17180	COG1982	Orn Lys Arg decarboxylase major
I6K60_RS17185	COG1811	Na channel or pump
I6K60_RS17215	COG0626	cystathionine gamma-synthase activity
I6K60_RS17220	COG0583	DNA-binding transcription factor activity
I6K60_RS17240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K60_RS17245	COG0754	glutathionylspermidine amidase activity
I6K60_RS17260	COG0625	glutathione transferase activity
I6K60_RS17285	COG2211	Major facilitator Superfamily
I6K60_RS17290	COG0848	biopolymer transport protein
I6K60_RS17300	COG0626	cystathionine gamma-synthase activity
I6K60_RS17305	COG0586	Pfam SNARE associated Golgi protein
I6K60_RS17310	COG2207	Transcriptional regulator
I6K60_RS17315	COG1979	alcohol dehydrogenase
I6K60_RS17320	COG0656	L-ascorbic acid biosynthetic process
I6K60_RS17330	COG1032	radical SAM domain protein
I6K60_RS17335	COG2132	Multicopper oxidase
I6K60_RS17340	COG0204	Acyl-transferase
I6K60_RS17345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K60_RS17350	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K60_RS17355	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K60_RS17365	COG0642	Histidine kinase
I6K60_RS17370	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K60_RS17375	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K60_RS17385	COG3150	esterase
I6K60_RS17390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K60_RS17395	COG3151	Protein conserved in bacteria
I6K60_RS17400	COG0494	nUDIX hydrolase
I6K60_RS17415	COG0754	glutathionylspermidine amidase activity
I6K60_RS17420	COG3384	dioxygenase
I6K60_RS17435	COG2960	long-chain fatty acid transporting porin activity
I6K60_RS17460	COG3025	triphosphatase activity
I6K60_RS17465	COG4991	sh3 domain protein
I6K60_RS17480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K60_RS17545	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K60_RS17550	COG0358	DNA primase activity
I6K60_RS17555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K60_RS17720	COG4695	Portal protein
I6K60_RS17750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K60_RS17785	COG4974	Belongs to the 'phage' integrase family
I6K60_RS17810	COG2197	response regulator
I6K60_RS17815	COG0784	Response regulator, receiver
I6K60_RS17815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS17815	COG2198	Histidine kinase
I6K60_RS17815	COG2205	protein histidine kinase activity
I6K60_RS17825	COG3247	response to pH
I6K60_RS17895	COG2376	Dihydroxyacetone kinase
I6K60_RS17900	COG1461	Dihydroxyacetone kinase
I6K60_RS17915	COG2375	cellular response to nickel ion
I6K60_RS17920	COG1695	Transcriptional regulator
I6K60_RS17970	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K60_RS17970	COG1902	pentaerythritol trinitrate reductase activity
I6K60_RS17990	COG1451	nucleotide metabolic process
I6K60_RS17995	COG0673	inositol 2-dehydrogenase activity
I6K60_RS18000	COG0861	Integral membrane protein TerC family
I6K60_RS18015	COG2721	sulfolactate sulfo-lyase activity
I6K60_RS18025	COG2271	Major facilitator Superfamily
I6K60_RS18030	COG2186	Transcriptional regulator
I6K60_RS18035	COG0586	Pfam SNARE associated Golgi protein
I6K60_RS18045	COG1422	Protein of unknown function (DUF1090)
I6K60_RS18050	COG4575	ribosome binding
I6K60_RS18055	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K60_RS18065	COG2259	Doxx family
I6K60_RS18070	COG0435	Glutathione S-transferase
I6K60_RS18075	COG3152	Membrane
I6K60_RS18080	COG0583	DNA-binding transcription factor activity
I6K60_RS18085	COG1741	Belongs to the pirin family
I6K60_RS18110	COG1929	Belongs to the glycerate kinase type-1 family
I6K60_RS18115	COG2084	Dehydrogenase
I6K60_RS18125	COG2271	Major facilitator Superfamily
I6K60_RS18130	COG2721	sulfolactate sulfo-lyase activity
I6K60_RS18135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K60_RS18155	COG2823	Periplasmic or secreted lipoprotein
I6K60_RS18160	COG0701	Predicted permease
I6K60_RS18165	COG0702	epimerase
I6K60_RS18170	COG0693	protein deglycase activity
I6K60_RS18185	COG3153	acetyltransferase
I6K60_RS18190	COG3154	lipid carrier protein
I6K60_RS18195	COG0826	peptidase U32
I6K60_RS18200	COG0826	peptidase U32
I6K60_RS18205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K60_RS18250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6K60_RS18275	COG0814	amino acid
I6K60_RS18320	COG0195	Participates in both transcription termination and antitermination
I6K60_RS18360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K60_RS18370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K60_RS18375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K60_RS18385	COG1534	Rna-binding protein
I6K60_RS18395	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K60_RS18405	COG0697	spore germination
I6K60_RS18420	COG0142	geranyltranstransferase activity
I6K60_RS18425	COG3423	Transcriptional regulator
I6K60_RS18435	COG5007	Belongs to the BolA IbaG family
I6K60_RS18440	COG3113	response to antibiotic
I6K60_RS18445	COG2854	intermembrane phospholipid transfer
I6K60_RS18450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K60_RS18455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K60_RS18460	COG1127	ABC transporter
I6K60_RS18465	COG0530	calcium, potassium:sodium antiporter activity
I6K60_RS18475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K60_RS18480	COG3117	lipopolysaccharide transmembrane transporter activity
I6K60_RS18485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K60_RS18490	COG1137	ATPase activity
I6K60_RS18495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K60_RS18500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K60_RS18505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS18515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS18520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K60_RS18525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K60_RS18530	COG0784	Response regulator, receiver
I6K60_RS18530	COG5002	protein histidine kinase activity
I6K60_RS18530	COG2198	Histidine kinase
I6K60_RS18535	COG1312	Catalyzes the dehydration of D-mannonate
I6K60_RS18540	COG1063	alcohol dehydrogenase
I6K60_RS18545	COG2271	Major facilitator Superfamily
I6K60_RS18550	COG1242	4 iron, 4 sulfur cluster binding
I6K60_RS18555	COG0069	glutamate synthase activity
I6K60_RS18555	COG0067	glutamate synthase
I6K60_RS18555	COG0070	glutamate synthase
I6K60_RS18560	COG0493	'glutamate synthase
I6K60_RS18570	COG2969	positive regulation of protein catabolic process
I6K60_RS18575	COG0625	glutathione transferase activity
I6K60_RS18595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K60_RS18600	COG3105	Protein conserved in bacteria
I6K60_RS18605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K60_RS18610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K60_RS18635	COG2732	(Barnase) inhibitor
I6K60_RS18640	COG1289	transmembrane transporter activity
I6K60_RS18655	COG0583	DNA-binding transcription factor activity
I6K60_RS18660	COG0312	modulator of DNA gyrase
I6K60_RS18665	COG3164	Protein of unknown function
I6K60_RS18670	COG1530	ribonuclease E activity
I6K60_RS18680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K60_RS18685	COG1792	Involved in formation and maintenance of cell shape
I6K60_RS18690	COG1077	Cell shape determining protein MreB Mrl
I6K60_RS18695	COG2200	EAL domain
I6K60_RS18695	COG2199	diguanylate cyclase activity
I6K60_RS18720	COG0511	ligase activity, forming carbon-carbon bonds
I6K60_RS18725	COG0439	Biotin carboxylase
I6K60_RS18730	COG3924	membrane
I6K60_RS18735	COG4145	pantothenate transmembrane transporter activity
I6K60_RS18755	COG1309	transcriptional regulator
I6K60_RS18760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS18765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K60_RS18800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K60_RS18820	COG0551	DNA topoisomerase type I activity
I6K60_RS18830	COG0758	DNA mediated transformation
I6K60_RS18860	COG3036	rescue of stalled ribosome
I6K60_RS18865	COG0789	Transcriptional regulator
I6K60_RS18880	COG0202	RNA polymerase activity
I6K60_RS18905	COG0201	protein transport
I6K60_RS18970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K60_RS18985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K60_RS19010	COG0051	transcription antitermination factor activity, RNA binding
I6K60_RS19065	COG2964	Protein conserved in bacteria
I6K60_RS19070	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K60_RS19080	COG1047	Peptidyl-prolyl cis-trans
I6K60_RS19085	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K60_RS19100	COG0488	(ABC) transporter
I6K60_RS19105	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K60_RS19115	COG3954	Phosphoribulokinase
I6K60_RS19120	COG1765	OsmC-like protein
I6K60_RS19130	COG1289	transmembrane transporter activity
I6K60_RS19135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K60_RS19160	COG0738	Major facilitator superfamily
I6K60_RS19165	COG0402	S-adenosylhomocysteine deaminase activity
I6K60_RS19170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K60_RS19195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K60_RS19200	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K60_RS19205	COG3266	domain, Protein
I6K60_RS19220	COG4796	Type ii and iii secretion system protein
I6K60_RS19245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K60_RS19250	COG0494	nUDIX hydrolase
I6K60_RS19260	COG1011	Hydrolase
I6K60_RS19265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K60_RS19290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K60_RS19295	COG2183	response to ionizing radiation
I6K60_RS19300	COG1918	ferrous iron import across plasma membrane
I6K60_RS19325	COG1040	competence protein
I6K60_RS19335	COG2610	gluconate transmembrane transporter activity
I6K60_RS19340	COG1640	4-alpha-glucanotransferase
I6K60_RS19345	COG0058	SHG alpha-glucan phosphorylase activity
I6K60_RS19355	COG1349	DNA-binding transcription factor activity
I6K60_RS19370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K60_RS19385	COG0058	SHG alpha-glucan phosphorylase activity
I6K60_RS19410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K60_RS19420	COG2610	gluconate transmembrane transporter activity
I6K60_RS19425	COG3265	gluconokinase activity
I6K60_RS19430	COG1609	Transcriptional regulator
I6K60_RS19435	COG1741	Belongs to the pirin family
I6K60_RS19440	COG0673	inositol 2-dehydrogenase activity
I6K60_RS19450	COG1247	-acetyltransferase
I6K60_RS19455	COG0405	Gamma-glutamyltransferase
I6K60_RS19465	COG0584	glycerophosphoryl diester phosphodiesterase
I6K60_RS19515	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS19520	COG0683	leucine binding
I6K60_RS19530	COG0683	leucine binding
I6K60_RS19540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K60_RS19555	COG2177	Part of the ABC transporter FtsEX involved in
I6K60_RS19560	COG2884	Cell division ATP-binding protein ftsE
I6K60_RS19565	COG0552	protein localization to endoplasmic reticulum
I6K60_RS19570	COG0742	ribosomal rna small subunit methyltransferase
I6K60_RS19575	COG3776	membrane
I6K60_RS19585	COG3714	YhhN family
I6K60_RS19600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K60_RS19610	COG0477	Major facilitator Superfamily
I6K60_RS19615	COG0628	permease
I6K60_RS19655	COG3479	Phenolic acid decarboxylase
I6K60_RS19665	COG0747	negative chemotaxis
I6K60_RS19670	COG0601	transmembrane transport
I6K60_RS19675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K60_RS19685	COG1124	(ABC) transporter
I6K60_RS19695	COG2239	Acts as a magnesium transporter
I6K60_RS19700	COG2081	HI0933 family
I6K60_RS19705	COG0306	phosphate transporter
I6K60_RS19715	COG0589	response to stress
I6K60_RS19735	COG0671	phosphoesterase, PA-phosphatase related
I6K60_RS19740	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K60_RS19745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K60_RS19755	COG1454	alcohol dehydrogenase
I6K60_RS19765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K60_RS19770	COG1028	Short-chain dehydrogenase reductase Sdr
I6K60_RS19775	COG0583	DNA-binding transcription factor activity
I6K60_RS19780	COG1295	ribonuclease BN
I6K60_RS19785	COG0477	Major facilitator Superfamily
I6K60_RS19790	COG2982	Protein involved in outer membrane biogenesis
I6K60_RS19800	COG0612	Peptidase, M16
I6K60_RS19810	COG2199	diguanylate cyclase activity
I6K60_RS19810	COG2200	EAL domain
I6K60_RS19815	COG3118	belongs to the thioredoxin family
I6K60_RS19815	COG0457	Tetratricopeptide repeat
I6K60_RS19820	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K60_RS19825	COG1215	transferase activity, transferring glycosyl groups
I6K60_RS19855	COG2194	sulfuric ester hydrolase activity
I6K60_RS19870	COG0457	Tetratricopeptide repeat
I6K60_RS19875	COG1215	transferase activity, transferring glycosyl groups
I6K60_RS19885	COG2894	cell division
I6K60_RS19900	COG4608	Belongs to the ABC transporter superfamily
I6K60_RS19905	COG0444	Belongs to the ABC transporter superfamily
I6K60_RS19910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K60_RS19915	COG0601	transmembrane transport
I6K60_RS19920	COG0747	negative chemotaxis
I6K60_RS19950	COG2223	nitrite transmembrane transporter activity
I6K60_RS19955	COG5571	outer membrane autotransporter
I6K60_RS19960	COG2818	Glycosylase
I6K60_RS19965	COG0456	acetyltransferase
I6K60_RS19970	COG0243	molybdopterin cofactor binding
I6K60_RS19975	COG2885	chlorophyll binding
I6K60_RS19980	COG1609	Transcriptional regulator
I6K60_RS19990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K60_RS20010	COG2814	Major facilitator Superfamily
I6K60_RS20015	COG2944	sequence-specific DNA binding
I6K60_RS20020	COG1278	Cold shock
I6K60_RS20075	COG3274	enterobacterial common antigen metabolic process
I6K60_RS20080	COG4682	membrane
I6K60_RS20085	COG4682	membrane
I6K60_RS20100	COG4213	ABC transporter substrate-binding protein
I6K60_RS20110	COG4214	carbohydrate transport
I6K60_RS20115	COG2207	Transcriptional regulator
I6K60_RS20115	COG1609	Transcriptional regulator
I6K60_RS20120	COG2992	FlgJ-related protein
I6K60_RS20125	COG0366	Alpha amylase catalytic
I6K60_RS20130	COG3977	Valine--pyruvate aminotransferase
I6K60_RS20135	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K60_RS20140	COG1414	Transcriptional regulator
I6K60_RS20145	COG3276	selenocysteine insertion sequence binding
I6K60_RS20155	COG0625	glutathione transferase activity
I6K60_RS20175	COG3722	fumarate hydratase activity
I6K60_RS20195	COG2186	Transcriptional regulator
I6K60_RS20205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K60_RS20225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K60_RS20230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K60_RS20240	COG4942	peptidase
I6K60_RS20245	COG2861	carbohydrate metabolic process
I6K60_RS20250	COG0463	Glycosyl transferase, family 2
I6K60_RS20260	COG0156	8-amino-7-oxononanoate synthase activity
I6K60_RS20275	COG0859	PFAM glycosyl transferase family 9
I6K60_RS20300	COG0859	PFAM glycosyl transferase family 9
I6K60_RS20310	COG0438	transferase activity, transferring glycosyl groups
I6K60_RS20315	COG1216	Glycosyl transferase, family 2
I6K60_RS20320	COG1519	Transferase
I6K60_RS20355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K60_RS20385	COG0842	Transport permease protein
I6K60_RS20390	COG1131	(ABC) transporter
I6K60_RS20410	COG1561	YicC-like family, N-terminal region
I6K60_RS20415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K60_RS20420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K60_RS20420	COG2169	Transcriptional regulator
I6K60_RS20430	COG2860	membrane
I6K60_RS20450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K60_RS20455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K60_RS20460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K60_RS20465	COG1494	fructose-1,6-bisphosphatase
I6K60_RS20475	COG3152	Membrane
I6K60_RS20500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K60_RS20520	COG0786	glutamate:sodium symporter activity
I6K60_RS20525	COG2233	PERMEase
I6K60_RS20530	COG2982	Protein involved in outer membrane biogenesis
I6K60_RS20535	COG1263	PTS System
I6K60_RS20535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS20540	COG1486	melibiose metabolic process
I6K60_RS20550	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K60_RS20555	COG2211	Major facilitator Superfamily
I6K60_RS20610	COG1064	alcohol dehydrogenase
I6K60_RS20620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K60_RS20635	COG1464	Belongs to the NlpA lipoprotein family
I6K60_RS20660	COG0583	DNA-binding transcription factor activity
I6K60_RS20695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K60_RS20705	COG2814	Major facilitator Superfamily
I6K60_RS20715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS20715	COG1263	PTS System
I6K60_RS20720	COG0697	spore germination
I6K60_RS20735	COG2828	Protein conserved in bacteria
I6K60_RS20740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K60_RS20745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K60_RS20750	COG0583	DNA-binding transcription factor activity
I6K60_RS20755	COG3384	dioxygenase
I6K60_RS20765	COG1609	Transcriptional regulator
I6K60_RS20775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS20775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS20780	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K60_RS20785	COG4580	involved in the transport of maltose and maltodextrins
I6K60_RS20810	COG2188	Transcriptional regulator
I6K60_RS20850	COG2271	Major facilitator Superfamily
I6K60_RS20860	COG2197	response regulator
I6K60_RS20865	COG0440	acetolactate synthase activity
I6K60_RS20870	COG0028	Belongs to the TPP enzyme family
I6K60_RS20900	COG2814	Major facilitator Superfamily
I6K60_RS20905	COG0583	DNA-binding transcription factor activity
I6K60_RS20915	COG2610	gluconate transmembrane transporter activity
I6K60_RS20935	COG2149	membrane
I6K60_RS20950	COG2188	Transcriptional regulator
I6K60_RS20960	COG3645	SOS response
I6K60_RS20975	COG5645	(Lipo)protein
I6K60_RS20980	COG0823	Involved in the tonB-independent uptake of proteins
I6K60_RS20985	COG2271	Major facilitator Superfamily
I6K60_RS20995	COG0800	Aldolase
I6K60_RS21000	COG3734	2-keto-3-deoxy-galactonokinase
I6K60_RS21005	COG2186	Transcriptional regulator
I6K60_RS21020	COG0561	phosphatase activity
I6K60_RS21025	COG0187	DNA topoisomerase II activity
I6K60_RS21055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K60_RS21085	COG2091	lysine biosynthetic process via aminoadipic acid
I6K60_RS21090	COG0431	NADPH-dependent FMN reductase
I6K60_RS21095	COG2252	PERMEase
I6K60_RS21100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K60_RS21105	COG0363	glucosamine-6-phosphate deaminase activity
I6K60_RS21110	COG2382	esterase
I6K60_RS21120	COG0704	Plays a role in the regulation of phosphate uptake
I6K60_RS21125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K60_RS21130	COG0581	inorganic phosphate transmembrane transporter activity
I6K60_RS21135	COG0573	inorganic phosphate transmembrane transporter activity
I6K60_RS21140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K60_RS21145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K60_RS21195	COG3312	ion transport
I6K60_RS21210	COG0716	FMN binding
I6K60_RS21215	COG1522	sequence-specific DNA binding
I6K60_RS21245	COG1129	ABC transporter
I6K60_RS21250	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS21260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K60_RS21265	COG1609	Transcriptional regulator
I6K60_RS21270	COG0477	Major facilitator Superfamily
I6K60_RS21275	COG2186	Transcriptional regulator
I6K60_RS21300	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K60_RS21310	COG3084	Protein conserved in bacteria
I6K60_RS21315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K60_RS21325	COG0204	Acyl-transferase
I6K60_RS21345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K60_RS21360	COG3852	Histidine kinase
I6K60_RS21375	COG1011	Hydrolase
I6K60_RS21390	COG0456	acetyltransferase
I6K60_RS21400	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K60_RS21415	COG2864	formate dehydrogenase
I6K60_RS21420	COG0437	4 iron, 4 sulfur cluster binding
I6K60_RS21510	COG2211	Major facilitator Superfamily
I6K60_RS21520	COG1454	alcohol dehydrogenase
I6K60_RS21525	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS21530	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS21535	COG1129	ABC transporter
I6K60_RS21575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K60_RS21580	COG2258	MOSC domain
I6K60_RS21585	COG2205	protein histidine kinase activity
I6K60_RS21590	COG0745	RESPONSE REGULATOR receiver
I6K60_RS21595	COG3678	ATP-independent chaperone mediated protein folding
I6K60_RS21615	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K60_RS21630	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K60_RS21635	COG1609	Transcriptional regulator
I6K60_RS21640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K60_RS21655	COG0626	cystathionine gamma-synthase activity
I6K60_RS21660	COG0460	homoserine dehydrogenase
I6K60_RS21660	COG0527	aspartate kinase activity
I6K60_RS21670	COG0737	Belongs to the 5'-nucleotidase family
I6K60_RS21680	COG0583	DNA-binding transcription factor activity
I6K60_RS21690	COG0697	spore germination
I6K60_RS21695	COG0371	Dehydrogenase
I6K60_RS21705	COG2207	Transcriptional regulator
I6K60_RS21710	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K60_RS21725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K60_RS21740	COG0583	DNA-binding transcription factor activity
I6K60_RS21815	COG3085	chromosome segregation
I6K60_RS21840	COG3978	acetolactate synthase activity
I6K60_RS21855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K60_RS21860	COG0583	DNA-binding transcription factor activity
I6K60_RS21870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K60_RS21875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K60_RS21885	COG1811	Na channel or pump
I6K60_RS21910	COG3118	belongs to the thioredoxin family
I6K60_RS21915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K60_RS21920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K60_RS21935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K60_RS21940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K60_RS21945	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K60_RS21950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K60_RS21955	COG0456	acetyltransferase
I6K60_RS21960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K60_RS21965	COG2244	polysaccharide biosynthetic process
I6K60_RS22010	COG3071	HemY protein
I6K60_RS22015	COG2959	enzyme of heme biosynthesis
I6K60_RS22030	COG3072	Adenylate cyclase
I6K60_RS22060	COG1011	Hydrolase
I6K60_RS22065	COG0210	DNA helicase
I6K60_RS22095	COG1280	lysine exporter protein (LysE YggA)
I6K60_RS22105	COG1280	lysine exporter protein (LysE YggA)
I6K60_RS22110	COG2267	carboxylic ester hydrolase activity
I6K60_RS22115	COG0561	phosphatase activity
I6K60_RS22120	COG0697	spore germination
I6K60_RS22125	COG0583	DNA-binding transcription factor activity
I6K60_RS22155	COG3165	ubiquinone biosynthetic process from chorismate
I6K60_RS22175	COG0805	protein transport
I6K60_RS22215	COG1739	Uncharacterized protein family UPF0029
I6K60_RS22225	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K60_RS22255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K60_RS22300	COG0250	Participates in transcription elongation, termination and antitermination
I6K60_RS22335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K60_RS22340	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K60_RS22350	COG3706	GGDEF domain
I6K60_RS22365	COG2104	thiamine diphosphate biosynthetic process
I6K60_RS22370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K60_RS22385	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6K60_RS22420	COG3678	ATP-independent chaperone mediated protein folding
I6K60_RS22425	COG4191	Histidine kinase
I6K60_RS22435	COG0151	Belongs to the GarS family
I6K60_RS22465	COG0456	acetyltransferase
I6K60_RS22475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K60_RS22505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K60_RS22560	COG0527	aspartate kinase activity
I6K60_RS22570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K60_RS22580	COG0251	oxidation-reduction process
I6K60_RS22650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K60_RS22660	COG0534	Mate efflux family protein
I6K60_RS22670	COG3237	CsbD-like
I6K60_RS22675	COG0735	belongs to the Fur family
I6K60_RS22685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K60_RS22700	COG0305	Participates in initiation and elongation during chromosome replication
I6K60_RS22705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K60_RS22720	COG0432	Pfam Uncharacterised protein family UPF0047
I6K60_RS22725	COG2315	Protein conserved in bacteria
I6K60_RS22740	COG0741	lytic transglycosylase activity
I6K60_RS22745	COG4771	TonB-dependent receptor
I6K60_RS22765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K60_RS22775	COG0483	inositol monophosphate 1-phosphatase activity
I6K60_RS22780	COG1609	Transcriptional regulator
I6K60_RS22785	COG1234	tRNA 3'-trailer cleavage
I6K60_RS22815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K60_RS22825	COG0789	Transcriptional regulator
I6K60_RS22830	COG0625	glutathione transferase activity
I6K60_RS22835	COG2252	PERMEase
I6K60_RS22840	COG0025	NhaP-type Na H and K H
I6K60_RS22845	COG0583	DNA-binding transcription factor activity
I6K60_RS22850	COG1380	Effector of murein hydrolase LrgA
I6K60_RS22855	COG1346	cytolysis
I6K60_RS22860	COG3539	Fimbrial protein
I6K60_RS22890	COG3162	membrane
I6K60_RS22895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K60_RS22905	COG1301	dicarboxylic acid transport
I6K60_RS22910	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K60_RS22945	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS22950	COG1129	ABC transporter
I6K60_RS22955	COG0784	Response regulator, receiver
I6K60_RS22955	COG4191	Histidine kinase
I6K60_RS22965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K60_RS22975	COG3454	Phosphonate metabolism
I6K60_RS22980	COG4778	phosphonate C-P lyase system protein PhnL
I6K60_RS22985	COG4107	phosphonate C-P lyase system protein PhnK
I6K60_RS22990	COG3627	carbon phosphorus lyase activity
I6K60_RS22995	COG3626	phosphonate metabolism
I6K60_RS23000	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K60_RS23005	COG3624	Phosphonate C-P lyase system protein PhnG
I6K60_RS23010	COG2188	Transcriptional regulator
I6K60_RS23015	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K60_RS23020	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K60_RS23030	COG2169	Transcriptional regulator
I6K60_RS23035	COG1486	melibiose metabolic process
I6K60_RS23080	COG0861	Integral membrane protein TerC family
I6K60_RS23095	COG1215	transferase activity, transferring glycosyl groups
I6K60_RS23100	COG0726	polysaccharide deacetylase
I6K60_RS23100	COG1649	PFAM Uncharacterised BCR, COG1649
I6K60_RS23105	COG0457	Tetratricopeptide repeat
I6K60_RS23135	COG1309	transcriptional regulator
I6K60_RS23150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K60_RS23155	COG1027	Aspartate ammonia-lyase
I6K60_RS23160	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K60_RS23165	COG0531	amino acid
I6K60_RS23230	COG1509	lysine 2,3-aminomutase activity
I6K60_RS23245	COG5510	response to toxic substance
I6K60_RS23250	COG2076	Multidrug Resistance protein
I6K60_RS23270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K60_RS23275	COG1053	succinate dehydrogenase
I6K60_RS23290	COG1511	domain protein
I6K60_RS23290	COG3264	Mechanosensitive ion channel
I6K60_RS23310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K60_RS23330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K60_RS23335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K60_RS23335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K60_RS23340	COG0802	atpase or kinase
I6K60_RS23345	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K60_RS23365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K60_RS23370	COG0330	HflC and HflK could
I6K60_RS23375	COG0330	HflC and HflK could
I6K60_RS23385	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K60_RS23400	COG0557	exoribonuclease II activity
I6K60_RS23405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K60_RS23410	COG1960	acyl-CoA dehydrogenase activity
I6K60_RS23420	COG3650	response to hydrogen peroxide
I6K60_RS23425	COG1073	alpha beta
I6K60_RS23485	COG2965	DNA replication, synthesis of RNA primer
I6K60_RS23490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K60_RS23500	COG3061	Opacity-associated protein A
I6K60_RS23505	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K60_RS23510	COG1113	amino acid transport
I6K60_RS23520	COG0697	spore germination
I6K60_RS23530	COG0702	epimerase
I6K60_RS23535	COG1733	regulation of RNA biosynthetic process
I6K60_RS23550	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K60_RS23575	COG1253	flavin adenine dinucleotide binding
I6K60_RS23585	COG0729	surface antigen
I6K60_RS23590	COG2911	Protein conserved in bacteria
I6K60_RS23595	COG2105	PFAM AIG2 family protein
I6K60_RS23610	COG1879	ABC-type sugar transport system periplasmic component
I6K60_RS23615	COG1129	ABC transporter
I6K60_RS23620	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS23625	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS23635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K60_RS23660	COG0312	modulator of DNA gyrase
I6K60_RS23700	COG3964	amidohydrolase
I6K60_RS23715	COG2706	6-phosphogluconolactonase activity
I6K60_RS23720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS23720	COG3711	transcriptional antiterminator
I6K60_RS23725	COG3077	Addiction module antitoxin, RelB DinJ family
I6K60_RS23730	COG2026	Addiction module toxin, RelE StbE family
I6K60_RS23735	COG0602	queuosine metabolic process
I6K60_RS23760	COG1486	melibiose metabolic process
I6K60_RS23765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS23770	COG0366	Alpha amylase catalytic
I6K60_RS23775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K60_RS23775	COG1263	PTS System
I6K60_RS23810	COG2731	YhcH YjgK YiaL family protein
I6K60_RS23835	COG0525	valine-tRNA ligase activity
I6K60_RS23840	COG2927	DNA polymerase III (CHI subunit)
I6K60_RS23850	COG0795	lipopolysaccharide-transporting ATPase activity
I6K60_RS23855	COG0795	lipopolysaccharide-transporting ATPase activity
I6K60_RS23860	COG0433	COG0433 Predicted ATPase
I6K60_RS23875	COG3718	enzyme involved in inositol metabolism
I6K60_RS23880	COG0837	glucose binding
I6K60_RS23880	COG1737	Transcriptional regulator
I6K60_RS23885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K60_RS23890	COG3962	Belongs to the TPP enzyme family
I6K60_RS23900	COG1082	Xylose isomerase domain protein TIM barrel
I6K60_RS23915	COG3842	ATPase activity
I6K60_RS23920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K60_RS23925	COG0395	ABC-type sugar transport system, permease component
I6K60_RS23930	COG1175	transmembrane transport
I6K60_RS23935	COG1064	alcohol dehydrogenase
I6K60_RS23940	COG0659	secondary active sulfate transmembrane transporter activity
I6K60_RS23945	COG0288	reversible hydration of carbon dioxide
I6K60_RS23975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6K60_RS23980	COG0514	ATP-dependent DNA helicase (RecQ)
I6K60_RS24015	COG0720	synthase
I6K60_RS24070	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K60_RS24080	COG0584	glycerophosphoryl diester phosphodiesterase
I6K60_RS24090	COG3507	Belongs to the glycosyl hydrolase 43 family
I6K60_RS24095	COG2211	Major facilitator Superfamily
I6K60_RS24100	COG2115	Belongs to the xylose isomerase family
I6K60_RS24105	COG4580	involved in the transport of maltose and maltodextrins
I6K60_RS24110	COG3272	Protein of unknown function (DUF1722)
I6K60_RS24130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K60_RS24145	COG0300	oxidoreductase activity
I6K60_RS24150	COG3631	Ketosteroid isomerase-related protein
I6K60_RS24155	COG0789	Transcriptional regulator
I6K60_RS24160	COG3040	lipid binding
I6K60_RS24170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K60_RS24175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS24180	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS24185	COG1538	Outer membrane efflux protein
I6K60_RS24190	COG0745	RESPONSE REGULATOR receiver
I6K60_RS24195	COG5002	protein histidine kinase activity
I6K60_RS24210	COG2850	peptidyl-arginine hydroxylation
I6K60_RS24240	COG0842	Transport permease protein
I6K60_RS24245	COG1129	ABC transporter
I6K60_RS24245	COG0842	Transport permease protein
I6K60_RS24250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K60_RS24260	COG1879	ABC-type sugar transport system periplasmic component
I6K60_RS24265	COG1129	ABC transporter
I6K60_RS24270	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K60_RS24280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K60_RS24285	COG0583	DNA-binding transcription factor activity
I6K60_RS24295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K60_RS24300	COG5457	Domain of unknown function (DUF1127)
I6K60_RS24310	COG1566	PFAM secretion protein HlyD family protein
I6K60_RS24325	COG1924	4 iron, 4 sulfur cluster binding
I6K60_RS24330	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K60_RS24345	COG2733	membrane
I6K60_RS24355	COG2207	Transcriptional regulator
I6K60_RS24355	COG1917	Cupin 2, conserved barrel domain protein
I6K60_RS24360	COG5464	transposase or invertase
I6K60_RS24365	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS24375	COG0523	cobalamin synthesis protein
I6K60_RS24380	COG2879	small protein
I6K60_RS24385	COG1966	Carbon starvation protein
I6K60_RS24400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K60_RS24405	COG2368	4-hydroxyphenylacetate
I6K60_RS24425	COG3971	2-oxopent-4-enoate hydratase activity
I6K60_RS24435	COG3384	dioxygenase
I6K60_RS24440	COG1012	belongs to the aldehyde dehydrogenase family
I6K60_RS24450	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K60_RS24460	COG1846	Transcriptional regulator
I6K60_RS24490	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K60_RS24505	COG3734	2-keto-3-deoxy-galactonokinase
I6K60_RS24510	COG0800	Aldolase
I6K60_RS24515	COG1737	Transcriptional regulator
I6K60_RS24525	COG0456	acetyltransferase
I6K60_RS24525	COG1214	PFAM Peptidase M22, glycoprotease
I6K60_RS24530	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6K60_RS24530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K60_RS24545	COG3715	PTS system
I6K60_RS24550	COG3716	PTS system mannose fructose sorbose family IID component
I6K60_RS24555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K60_RS24565	COG5464	transposase or invertase
I6K60_RS24580	COG1484	DNA-dependent DNA replication
I6K60_RS24595	COG2966	Psort location CytoplasmicMembrane, score
I6K60_RS24610	COG2197	response regulator
I6K60_RS24615	COG2197	response regulator
I6K60_RS24620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K60_RS24625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS24625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K60_RS24630	COG4114	ferric iron reductase
I6K60_RS24635	COG3706	GGDEF domain
I6K60_RS24670	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K60_RS24675	COG0456	acetyltransferase
I6K60_RS24680	COG1011	Hydrolase
I6K60_RS24690	COG2823	Periplasmic or secreted lipoprotein
I6K60_RS24700	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K60_RS24705	COG0084	hydrolase, TatD family'
I6K60_RS24710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K60_RS24740	COG3726	membrane protein affecting hemolysin expression
I6K60_RS24745	COG0560	Phosphoserine phosphatase
I6K60_RS24750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K60_RS24760	COG0488	(ABC) transporter
I6K60_RS24765	COG0741	lytic transglycosylase activity
I6K60_RS24785	COG3708	Transcriptional regulator
I6K60_RS24785	COG2207	Transcriptional regulator
I6K60_RS24790	COG3045	CreA protein
I6K60_RS24795	COG0745	RESPONSE REGULATOR receiver
I6K60_RS24800	COG2205	protein histidine kinase activity
I6K60_RS24805	COG4452	Inner membrane protein CreD
I6K60_RS24810	COG0745	RESPONSE REGULATOR receiver
I6K60_RS24820	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K60_RS24830	COG0527	aspartate kinase activity
I6K60_RS24830	COG0460	homoserine dehydrogenase
I6K60_RS24840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K60_RS24855	COG1115	amino acid carrier protein
I6K60_RS24860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K60_RS24865	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K60_RS24870	COG0477	Major facilitator Superfamily
I6K60_RS24875	COG1584	GPR1 FUN34 yaaH family protein
I6K60_RS24880	COG4735	regulation of single-species biofilm formation
I6K60_RS24905	COG0583	DNA-binding transcription factor activity
I6K60_RS24915	COG0196	riboflavin kinase activity
I6K60_RS24930	COG1047	Peptidyl-prolyl cis-trans
I6K60_RS24955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K60_RS25020	COG0505	Belongs to the CarA family
I6K60_RS25065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K60_RS25075	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K60_RS25080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K60_RS25095	COG3493	citrate carrier protein
I6K60_RS25105	COG0564	pseudouridine synthase activity
I6K60_RS25115	COG0417	DNA replication proofreading
I6K60_RS25120	COG0235	Class ii aldolase
I6K60_RS25140	COG0586	Pfam SNARE associated Golgi protein
I6K60_RS25150	COG1178	ABC-type Fe3 transport system permease component
I6K60_RS25170	COG2814	Major facilitator Superfamily
I6K60_RS25175	COG2271	Major facilitator Superfamily
I6K60_RS25180	COG0583	DNA-binding transcription factor activity
I6K60_RS25190	COG0738	Major facilitator superfamily
I6K60_RS25235	COG0028	Belongs to the TPP enzyme family
I6K60_RS25245	COG1609	Transcriptional regulator
I6K60_RS25265	COG0768	penicillin binding
I6K60_RS25270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K60_RS25275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K60_RS25290	COG0772	Belongs to the SEDS family
I6K60_RS25315	COG0849	cell division
I6K60_RS25320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K60_RS25340	COG0494	nUDIX hydrolase
I6K60_RS25365	COG1459	type II secretion system
I6K60_RS25370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K60_RS25375	COG4969	Belongs to the N-Me-Phe pilin family
I6K60_RS25385	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K60_RS25390	COG3725	Membrane protein required for beta-lactamase induction
I6K60_RS25395	COG3940	Belongs to the glycosyl hydrolase 43 family
I6K60_RS25400	COG2211	Major facilitator Superfamily
I6K60_RS25405	COG1113	amino acid transport
I6K60_RS25410	COG2186	Transcriptional regulator
I6K60_RS25415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K60_RS25420	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K60_RS25425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K60_RS25480	COG2132	Multicopper oxidase
I6K60_RS25485	COG4993	Dehydrogenase
I6K60_RS25500	COG0288	reversible hydration of carbon dioxide
I6K60_RS25505	COG1131	(ABC) transporter
I6K60_RS25510	COG0842	Transport permease protein
I6K60_RS25515	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K60_RS25520	COG0726	polysaccharide deacetylase
I6K60_RS25540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K60_RS25545	COG0617	tRNA 3'-terminal CCA addition
I6K60_RS25565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K60_RS25570	COG1643	Atp-dependent helicase
I6K60_RS25665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K60_RS25670	COG4774	siderophore transport
I6K60_RS25675	COG1120	ATPase activity
I6K60_RS25680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K60_RS25685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K60_RS25705	COG2860	membrane
I6K60_RS25725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K60_RS25730	COG3835	regulator
I6K60_RS25745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K60_RS25750	COG0024	Methionine aminopeptidase
I6K60_RS25775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K60_RS25785	COG0575	Belongs to the CDS family
I6K60_RS25790	COG0750	zinc metalloprotease
I6K60_RS25800	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K60_RS25830	COG0587	DNA-directed DNA polymerase activity
I6K60_RS25840	COG1982	Orn Lys Arg decarboxylase major
I6K60_RS25845	COG0346	lactoylglutathione lyase activity
I6K60_RS25855	COG4568	rho-dependent transcription termination
I6K60_RS25870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K60_RS25875	COG3015	lipoprotein NlpE involved in copper resistance
I6K60_RS25880	COG0791	NLP P60 protein
I6K60_RS25890	COG1720	tRNA m6t6A37 methyltransferase activity
I6K60_RS25900	COG1464	Belongs to the NlpA lipoprotein family
I6K60_RS25905	COG2011	ABC-type metal ion transport system permease component
I6K60_RS25915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K60_RS25980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K60_RS26060	COG0697	spore germination
I6K60_RS26145	COG2003	Belongs to the UPF0758 family
I6K60_RS26225	COG0784	Response regulator, receiver
I6K60_RS26225	COG5002	protein histidine kinase activity
I6K60_RS26225	COG2198	Histidine kinase
I6K60_RS26250	COG0741	lytic transglycosylase activity
I6K60_RS26425	COG1160	GTP binding
I6K60_RS26600	COG0629	single-stranded DNA binding