locus-tag	class	description
IS497_RS00020	COG0187	DNA topoisomerase II activity
IS497_RS00025	COG0561	phosphatase activity
IS497_RS00040	COG2186	Transcriptional regulator
IS497_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
IS497_RS00050	COG0800	Aldolase
IS497_RS00070	COG2271	Major facilitator Superfamily
IS497_RS00075	COG0823	Involved in the tonB-independent uptake of proteins
IS497_RS00080	COG5645	(Lipo)protein
IS497_RS00095	COG3645	SOS response
IS497_RS00105	COG2188	Transcriptional regulator
IS497_RS00120	COG2149	membrane
IS497_RS00140	COG2610	gluconate transmembrane transporter activity
IS497_RS00150	COG0583	DNA-binding transcription factor activity
IS497_RS00155	COG2814	Major facilitator Superfamily
IS497_RS00185	COG0028	Belongs to the TPP enzyme family
IS497_RS00190	COG0440	acetolactate synthase activity
IS497_RS00195	COG2197	response regulator
IS497_RS00205	COG2271	Major facilitator Superfamily
IS497_RS00245	COG2188	Transcriptional regulator
IS497_RS00270	COG4580	involved in the transport of maltose and maltodextrins
IS497_RS00275	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS497_RS00280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS00280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS00290	COG1609	Transcriptional regulator
IS497_RS00300	COG3384	dioxygenase
IS497_RS00305	COG0583	DNA-binding transcription factor activity
IS497_RS00310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IS497_RS00315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS497_RS00320	COG2828	Protein conserved in bacteria
IS497_RS00335	COG0697	spore germination
IS497_RS00340	COG1263	PTS System
IS497_RS00340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS00350	COG2814	Major facilitator Superfamily
IS497_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS497_RS00395	COG0583	DNA-binding transcription factor activity
IS497_RS00420	COG1464	Belongs to the NlpA lipoprotein family
IS497_RS00435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IS497_RS00445	COG1064	alcohol dehydrogenase
IS497_RS00475	COG2211	Major facilitator Superfamily
IS497_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
IS497_RS00490	COG1486	melibiose metabolic process
IS497_RS00495	COG1263	PTS System
IS497_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS00500	COG2982	Protein involved in outer membrane biogenesis
IS497_RS00505	COG2233	PERMEase
IS497_RS00510	COG0786	glutamate:sodium symporter activity
IS497_RS00530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IS497_RS00555	COG3152	Membrane
IS497_RS00565	COG1494	fructose-1,6-bisphosphatase
IS497_RS00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IS497_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS497_RS00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS497_RS00600	COG2860	membrane
IS497_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS497_RS00610	COG2169	Transcriptional regulator
IS497_RS00615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IS497_RS00620	COG1561	YicC-like family, N-terminal region
IS497_RS00625	COG3039	Transposase
IS497_RS00645	COG1131	(ABC) transporter
IS497_RS00650	COG0842	Transport permease protein
IS497_RS00675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IS497_RS00710	COG1519	Transferase
IS497_RS00715	COG1216	Glycosyl transferase, family 2
IS497_RS00720	COG0438	transferase activity, transferring glycosyl groups
IS497_RS00730	COG0859	PFAM glycosyl transferase family 9
IS497_RS00755	COG0859	PFAM glycosyl transferase family 9
IS497_RS00770	COG0156	8-amino-7-oxononanoate synthase activity
IS497_RS00780	COG0463	Glycosyl transferase, family 2
IS497_RS00785	COG2861	carbohydrate metabolic process
IS497_RS00790	COG4942	peptidase
IS497_RS00800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS497_RS00805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS497_RS00825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IS497_RS00835	COG2186	Transcriptional regulator
IS497_RS00855	COG3722	fumarate hydratase activity
IS497_RS00875	COG1566	PFAM secretion protein HlyD family protein
IS497_RS00880	COG0625	glutathione transferase activity
IS497_RS00890	COG3276	selenocysteine insertion sequence binding
IS497_RS00895	COG1414	Transcriptional regulator
IS497_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS497_RS00905	COG3977	Valine--pyruvate aminotransferase
IS497_RS00910	COG0366	Alpha amylase catalytic
IS497_RS00915	COG2992	FlgJ-related protein
IS497_RS00920	COG1609	Transcriptional regulator
IS497_RS00920	COG2207	Transcriptional regulator
IS497_RS00925	COG4214	carbohydrate transport
IS497_RS00935	COG4213	ABC transporter substrate-binding protein
IS497_RS00950	COG4682	membrane
IS497_RS00955	COG4682	membrane
IS497_RS00960	COG3274	enterobacterial common antigen metabolic process
IS497_RS00995	COG1278	Cold shock
IS497_RS01000	COG2944	sequence-specific DNA binding
IS497_RS01005	COG2814	Major facilitator Superfamily
IS497_RS01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS01035	COG1609	Transcriptional regulator
IS497_RS01040	COG2885	chlorophyll binding
IS497_RS01045	COG0243	molybdopterin cofactor binding
IS497_RS01050	COG0456	acetyltransferase
IS497_RS01055	COG2818	Glycosylase
IS497_RS01060	COG5571	outer membrane autotransporter
IS497_RS01065	COG2223	nitrite transmembrane transporter activity
IS497_RS01095	COG0747	negative chemotaxis
IS497_RS01100	COG0601	transmembrane transport
IS497_RS01105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS497_RS01110	COG0444	Belongs to the ABC transporter superfamily
IS497_RS01115	COG4608	Belongs to the ABC transporter superfamily
IS497_RS01140	COG1215	transferase activity, transferring glycosyl groups
IS497_RS01145	COG0457	Tetratricopeptide repeat
IS497_RS01160	COG2194	sulfuric ester hydrolase activity
IS497_RS01190	COG1215	transferase activity, transferring glycosyl groups
IS497_RS01195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IS497_RS01200	COG0457	Tetratricopeptide repeat
IS497_RS01200	COG3118	belongs to the thioredoxin family
IS497_RS01205	COG2199	diguanylate cyclase activity
IS497_RS01205	COG2200	EAL domain
IS497_RS01215	COG0612	Peptidase, M16
IS497_RS01225	COG2982	Protein involved in outer membrane biogenesis
IS497_RS01230	COG0477	Major facilitator Superfamily
IS497_RS01235	COG1295	ribonuclease BN
IS497_RS01240	COG0583	DNA-binding transcription factor activity
IS497_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS01250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS497_RS01260	COG1454	alcohol dehydrogenase
IS497_RS01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS497_RS01275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IS497_RS01280	COG0671	phosphoesterase, PA-phosphatase related
IS497_RS01300	COG0589	response to stress
IS497_RS01310	COG0306	phosphate transporter
IS497_RS01315	COG2081	HI0933 family
IS497_RS01320	COG2239	Acts as a magnesium transporter
IS497_RS01330	COG1124	(ABC) transporter
IS497_RS01340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS497_RS01345	COG0601	transmembrane transport
IS497_RS01350	COG0747	negative chemotaxis
IS497_RS01360	COG3479	Phenolic acid decarboxylase
IS497_RS01400	COG0628	permease
IS497_RS01405	COG0477	Major facilitator Superfamily
IS497_RS01415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS497_RS01430	COG3714	YhhN family
IS497_RS01440	COG3776	membrane
IS497_RS01445	COG0742	ribosomal rna small subunit methyltransferase
IS497_RS01450	COG0552	protein localization to endoplasmic reticulum
IS497_RS01455	COG2884	Cell division ATP-binding protein ftsE
IS497_RS01460	COG2177	Part of the ABC transporter FtsEX involved in
IS497_RS01475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS497_RS01485	COG0683	leucine binding
IS497_RS01495	COG0683	leucine binding
IS497_RS01500	COG0559	Belongs to the binding-protein-dependent transport system permease family
IS497_RS01550	COG0584	glycerophosphoryl diester phosphodiesterase
IS497_RS01560	COG0405	Gamma-glutamyltransferase
IS497_RS01565	COG1247	-acetyltransferase
IS497_RS01575	COG0673	inositol 2-dehydrogenase activity
IS497_RS01580	COG1741	Belongs to the pirin family
IS497_RS01585	COG1609	Transcriptional regulator
IS497_RS01590	COG3265	gluconokinase activity
IS497_RS01595	COG2610	gluconate transmembrane transporter activity
IS497_RS01605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS497_RS01630	COG0058	SHG alpha-glucan phosphorylase activity
IS497_RS01645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS497_RS01660	COG1349	DNA-binding transcription factor activity
IS497_RS01670	COG0058	SHG alpha-glucan phosphorylase activity
IS497_RS01675	COG1640	4-alpha-glucanotransferase
IS497_RS01680	COG2610	gluconate transmembrane transporter activity
IS497_RS01690	COG1040	competence protein
IS497_RS01715	COG1918	ferrous iron import across plasma membrane
IS497_RS01720	COG2183	response to ionizing radiation
IS497_RS01725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS497_RS01750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IS497_RS01755	COG1011	Hydrolase
IS497_RS01765	COG0494	nUDIX hydrolase
IS497_RS01770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IS497_RS01795	COG4796	Type ii and iii secretion system protein
IS497_RS01810	COG3266	domain, Protein
IS497_RS01815	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IS497_RS01820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS497_RS01845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS497_RS01850	COG0402	S-adenosylhomocysteine deaminase activity
IS497_RS01855	COG0738	Major facilitator superfamily
IS497_RS01880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS497_RS01885	COG1289	transmembrane transporter activity
IS497_RS01895	COG1765	OsmC-like protein
IS497_RS01900	COG3954	Phosphoribulokinase
IS497_RS01910	COG0429	hydrolase of the alpha beta-hydrolase fold
IS497_RS01915	COG0488	(ABC) transporter
IS497_RS01930	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IS497_RS01935	COG1047	Peptidyl-prolyl cis-trans
IS497_RS01945	COG0545	Peptidyl-prolyl cis-trans isomerase
IS497_RS01950	COG2964	Protein conserved in bacteria
IS497_RS02005	COG0051	transcription antitermination factor activity, RNA binding
IS497_RS02030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IS497_RS02045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IS497_RS02110	COG0201	protein transport
IS497_RS02135	COG0202	RNA polymerase activity
IS497_RS02150	COG0789	Transcriptional regulator
IS497_RS02155	COG3036	rescue of stalled ribosome
IS497_RS02185	COG0758	DNA mediated transformation
IS497_RS02195	COG0551	DNA topoisomerase type I activity
IS497_RS02215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS497_RS02250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS497_RS02255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS02260	COG1309	transcriptional regulator
IS497_RS02265	COG0582	viral genome integration into host DNA
IS497_RS02280	COG3561	AntA/AntB antirepressor
IS497_RS02365	COG4626	Terminase
IS497_RS02365	COG1802	Transcriptional regulator
IS497_RS02390	COG4145	pantothenate transmembrane transporter activity
IS497_RS02395	COG3924	membrane
IS497_RS02400	COG0439	Biotin carboxylase
IS497_RS02405	COG0511	ligase activity, forming carbon-carbon bonds
IS497_RS02430	COG2200	EAL domain
IS497_RS02430	COG2199	diguanylate cyclase activity
IS497_RS02435	COG1077	Cell shape determining protein MreB Mrl
IS497_RS02440	COG1792	Involved in formation and maintenance of cell shape
IS497_RS02445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IS497_RS02455	COG1530	ribonuclease E activity
IS497_RS02460	COG3164	Protein of unknown function
IS497_RS02465	COG0312	modulator of DNA gyrase
IS497_RS02470	COG0583	DNA-binding transcription factor activity
IS497_RS02485	COG1289	transmembrane transporter activity
IS497_RS02490	COG2732	(Barnase) inhibitor
IS497_RS02515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS497_RS02520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS497_RS02525	COG3105	Protein conserved in bacteria
IS497_RS02530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS497_RS02550	COG0625	glutathione transferase activity
IS497_RS02555	COG2969	positive regulation of protein catabolic process
IS497_RS02565	COG0493	'glutamate synthase
IS497_RS02570	COG0070	glutamate synthase
IS497_RS02570	COG0069	glutamate synthase activity
IS497_RS02570	COG0067	glutamate synthase
IS497_RS02575	COG1242	4 iron, 4 sulfur cluster binding
IS497_RS02580	COG2271	Major facilitator Superfamily
IS497_RS02585	COG1063	alcohol dehydrogenase
IS497_RS02590	COG1312	Catalyzes the dehydration of D-mannonate
IS497_RS02595	COG5002	protein histidine kinase activity
IS497_RS02595	COG2198	Histidine kinase
IS497_RS02595	COG0784	Response regulator, receiver
IS497_RS02600	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IS497_RS02605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS497_RS02610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS02620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS02625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS497_RS02630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IS497_RS02635	COG1137	ATPase activity
IS497_RS02640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IS497_RS02645	COG3117	lipopolysaccharide transmembrane transporter activity
IS497_RS02650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IS497_RS02660	COG0530	calcium, potassium:sodium antiporter activity
IS497_RS02665	COG1127	ABC transporter
IS497_RS02670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS497_RS02675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS497_RS02680	COG2854	intermembrane phospholipid transfer
IS497_RS02685	COG3113	response to antibiotic
IS497_RS02690	COG5007	Belongs to the BolA IbaG family
IS497_RS02700	COG3423	Transcriptional regulator
IS497_RS02705	COG0142	geranyltranstransferase activity
IS497_RS02720	COG0697	spore germination
IS497_RS02730	COG2027	D-alanyl-D-alanine carboxypeptidase
IS497_RS02740	COG1534	Rna-binding protein
IS497_RS02750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IS497_RS02755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IS497_RS02765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IS497_RS02805	COG0195	Participates in both transcription termination and antitermination
IS497_RS02850	COG0814	amino acid
IS497_RS02855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS497_RS02860	COG0826	peptidase U32
IS497_RS02865	COG0826	peptidase U32
IS497_RS02870	COG3154	lipid carrier protein
IS497_RS02875	COG3153	acetyltransferase
IS497_RS02890	COG0693	protein deglycase activity
IS497_RS02895	COG0702	epimerase
IS497_RS02900	COG0701	Predicted permease
IS497_RS02905	COG2823	Periplasmic or secreted lipoprotein
IS497_RS02925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IS497_RS02940	COG1063	alcohol dehydrogenase
IS497_RS02945	COG3775	system Galactitol-specific IIC component
IS497_RS02950	COG3414	Phosphotransferase system galactitol-specific IIB component
IS497_RS02955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS02965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS02970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS02970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS497_RS02970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS497_RS02975	COG1105	Belongs to the carbohydrate kinase PfkB family
IS497_RS02985	COG1349	DNA-binding transcription factor activity
IS497_RS02990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS02995	COG2721	sulfolactate sulfo-lyase activity
IS497_RS03000	COG2271	Major facilitator Superfamily
IS497_RS03010	COG2084	Dehydrogenase
IS497_RS03015	COG1929	Belongs to the glycerate kinase type-1 family
IS497_RS03040	COG1741	Belongs to the pirin family
IS497_RS03045	COG0583	DNA-binding transcription factor activity
IS497_RS03050	COG3152	Membrane
IS497_RS03055	COG0435	Glutathione S-transferase
IS497_RS03060	COG2259	Doxx family
IS497_RS03070	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IS497_RS03075	COG4575	ribosome binding
IS497_RS03080	COG1422	Protein of unknown function (DUF1090)
IS497_RS03090	COG0586	Pfam SNARE associated Golgi protein
IS497_RS03095	COG2186	Transcriptional regulator
IS497_RS03100	COG2271	Major facilitator Superfamily
IS497_RS03110	COG2721	sulfolactate sulfo-lyase activity
IS497_RS03125	COG0861	Integral membrane protein TerC family
IS497_RS03130	COG0673	inositol 2-dehydrogenase activity
IS497_RS03135	COG1451	nucleotide metabolic process
IS497_RS03155	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS497_RS03155	COG1902	pentaerythritol trinitrate reductase activity
IS497_RS03205	COG1695	Transcriptional regulator
IS497_RS03210	COG2375	cellular response to nickel ion
IS497_RS03225	COG1461	Dihydroxyacetone kinase
IS497_RS03230	COG2376	Dihydroxyacetone kinase
IS497_RS03300	COG3247	response to pH
IS497_RS03310	COG2198	Histidine kinase
IS497_RS03310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS03310	COG0784	Response regulator, receiver
IS497_RS03310	COG2205	protein histidine kinase activity
IS497_RS03315	COG2197	response regulator
IS497_RS03340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS497_RS03345	COG0358	DNA primase activity
IS497_RS03350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IS497_RS03420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS497_RS03435	COG4991	sh3 domain protein
IS497_RS03440	COG3025	triphosphatase activity
IS497_RS03465	COG2960	long-chain fatty acid transporting porin activity
IS497_RS03480	COG3384	dioxygenase
IS497_RS03485	COG0754	glutathionylspermidine amidase activity
IS497_RS03500	COG0494	nUDIX hydrolase
IS497_RS03505	COG3151	Protein conserved in bacteria
IS497_RS03510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS497_RS03515	COG3150	esterase
IS497_RS03525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IS497_RS03530	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS497_RS03535	COG0642	Histidine kinase
IS497_RS03545	COG3111	PFAM Bacterial OB fold (BOF) protein
IS497_RS03550	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IS497_RS03555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IS497_RS03560	COG0204	Acyl-transferase
IS497_RS03565	COG2132	Multicopper oxidase
IS497_RS03570	COG1032	radical SAM domain protein
IS497_RS03580	COG0656	L-ascorbic acid biosynthetic process
IS497_RS03585	COG1979	alcohol dehydrogenase
IS497_RS03590	COG2207	Transcriptional regulator
IS497_RS03595	COG0586	Pfam SNARE associated Golgi protein
IS497_RS03600	COG0626	cystathionine gamma-synthase activity
IS497_RS03610	COG0848	biopolymer transport protein
IS497_RS03615	COG2211	Major facilitator Superfamily
IS497_RS03640	COG0625	glutathione transferase activity
IS497_RS03655	COG0754	glutathionylspermidine amidase activity
IS497_RS03660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS497_RS03680	COG0583	DNA-binding transcription factor activity
IS497_RS03685	COG0626	cystathionine gamma-synthase activity
IS497_RS03895	COG3039	Transposase
IS497_RS03945	COG3423	Transcriptional regulator
IS497_RS03955	COG1278	Cold shock
IS497_RS03960	COG3423	Transcriptional regulator
IS497_RS04025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS497_RS04035	COG1811	Na channel or pump
IS497_RS04040	COG1982	Orn Lys Arg decarboxylase major
IS497_RS04045	COG2211	Major facilitator Superfamily
IS497_RS04060	COG1194	a g-specific adenine glycosylase
IS497_RS04070	COG3171	Protein conserved in bacteria
IS497_RS04080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS497_RS04095	COG0762	integral membrane protein
IS497_RS04100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IS497_RS04105	COG2805	Type II/IV secretion system protein
IS497_RS04125	COG0189	ligase activity
IS497_RS04130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IS497_RS04135	COG2356	endonuclease I
IS497_RS04145	COG2814	Major facilitator Superfamily
IS497_RS04180	COG2146	nitrite reductase [NAD(P)H] activity
IS497_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS04200	COG1414	Transcriptional regulator
IS497_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS04235	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IS497_RS04260	COG0501	Belongs to the peptidase M48B family
IS497_RS04265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS497_RS04280	COG0191	fructose-bisphosphate aldolase activity
IS497_RS04285	COG0668	transmembrane transport
IS497_RS04295	COG2968	Membrane
IS497_RS04310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS497_RS04315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IS497_RS04335	COG0006	proline dipeptidase activity
IS497_RS04340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS497_RS04345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS497_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS04370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS497_RS04390	COG2723	6-phospho-beta-galactosidase activity
IS497_RS04395	COG1737	Transcriptional regulator
IS497_RS04405	COG1272	protein, Hemolysin III
IS497_RS04415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IS497_RS04425	COG0716	FMN binding
IS497_RS04430	COG4974	Belongs to the 'phage' integrase family
IS497_RS04440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IS497_RS04460	COG4942	peptidase
IS497_RS04470	COG2814	Major facilitator Superfamily
IS497_RS04485	COG0667	Aldo Keto reductase
IS497_RS04520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS497_RS04525	COG1393	Belongs to the ArsC family
IS497_RS04540	COG1538	Outer membrane efflux protein
IS497_RS04545	COG1289	transmembrane transporter activity
IS497_RS04560	COG3592	Divergent 4Fe-4S mono-cluster
IS497_RS04565	COG2388	GCN5-related N-acetyl-transferase
IS497_RS04575	COG3539	Fimbrial protein
IS497_RS04580	COG3539	Fimbrial protein
IS497_RS04585	COG3539	Fimbrial protein
IS497_RS04590	COG3188	usher protein
IS497_RS04595	COG3121	Chaperone
IS497_RS04600	COG3539	Fimbrial protein
IS497_RS04610	COG4974	Belongs to the 'phage' integrase family
IS497_RS04615	COG0582	viral genome integration into host DNA
IS497_RS04620	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS497_RS04625	COG1846	Transcriptional regulator
IS497_RS04630	COG0697	spore germination
IS497_RS04680	COG0667	Aldo Keto reductase
IS497_RS04685	COG0814	amino acid
IS497_RS04700	COG0183	Belongs to the thiolase family
IS497_RS04710	COG0823	Involved in the tonB-independent uptake of proteins
IS497_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS04720	COG2814	Major facilitator Superfamily
IS497_RS04755	COG3842	ATPase activity
IS497_RS04760	COG0395	ABC-type sugar transport system, permease component
IS497_RS04765	COG1175	transmembrane transport
IS497_RS04770	COG1917	Cupin 2, conserved barrel domain protein
IS497_RS04775	COG1794	racemase activity, acting on amino acids and derivatives
IS497_RS04780	COG0583	DNA-binding transcription factor activity
IS497_RS04790	COG1609	Transcriptional regulator
IS497_RS04795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS04800	COG2723	6-phospho-beta-galactosidase activity
IS497_RS04805	COG2186	Transcriptional regulator
IS497_RS04815	COG1609	Transcriptional regulator
IS497_RS04835	COG0667	Aldo Keto reductase
IS497_RS04845	COG0861	Integral membrane protein TerC family
IS497_RS04880	COG2165	general secretion pathway protein
IS497_RS04885	COG4795	General secretion pathway protein
IS497_RS04895	COG4967	type IV pilus modification protein PilV
IS497_RS04900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IS497_RS04905	COG1025	Belongs to the peptidase M16 family
IS497_RS04910	COG1074	ATP-dependent DNA helicase activity
IS497_RS04915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IS497_RS04925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IS497_RS04925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IS497_RS04930	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS497_RS04935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS497_RS04965	COG4656	Part of a membrane complex involved in electron transport
IS497_RS04970	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS04970	COG1454	alcohol dehydrogenase
IS497_RS05000	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IS497_RS05165	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IS497_RS05170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IS497_RS05175	COG2166	iron-sulfur cluster assembly
IS497_RS05180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS497_RS05190	COG0583	DNA-binding transcription factor activity
IS497_RS05195	COG2363	Small membrane protein
IS497_RS05205	COG1349	DNA-binding transcription factor activity
IS497_RS05225	COG0738	Major facilitator superfamily
IS497_RS05230	COG0235	Class ii aldolase
IS497_RS05235	COG1454	alcohol dehydrogenase
IS497_RS05255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS497_RS05270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS497_RS05275	COG2011	ABC-type metal ion transport system permease component
IS497_RS05280	COG1464	Belongs to the NlpA lipoprotein family
IS497_RS05285	COG0477	Major facilitator Superfamily
IS497_RS05295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS497_RS05300	COG1760	l-serine dehydratase
IS497_RS05305	COG0814	amino acid
IS497_RS05310	COG1611	Belongs to the LOG family
IS497_RS05325	COG3098	single-species biofilm formation
IS497_RS05330	COG0564	pseudouridine synthase activity
IS497_RS05335	COG0716	FMN binding
IS497_RS05340	COG2271	Major facilitator Superfamily
IS497_RS05345	COG4948	Mandelate Racemase Muconate Lactonizing
IS497_RS05350	COG4948	Mandelate Racemase Muconate Lactonizing
IS497_RS05355	COG1929	Belongs to the glycerate kinase type-1 family
IS497_RS05360	COG2205	protein histidine kinase activity
IS497_RS05360	COG3437	response regulator, receiver
IS497_RS05360	COG3850	Histidine kinase
IS497_RS05360	COG4999	Histidine kinase
IS497_RS05370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS497_RS05375	COG3956	TIGRFAM MazG family protein
IS497_RS05395	COG0602	queuosine metabolic process
IS497_RS05400	COG0720	synthase
IS497_RS05420	COG2234	aminopeptidase activity
IS497_RS05480	COG4942	peptidase
IS497_RS05480	COG1388	LysM domain
IS497_RS05485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS497_RS05510	COG0163	prenyltransferase activity
IS497_RS05515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS497_RS05555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS05560	COG4558	Periplasmic binding protein
IS497_RS05565	COG3720	iron ion transport
IS497_RS05585	COG0679	Auxin Efflux Carrier
IS497_RS05600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS497_RS05605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS497_RS05610	COG1121	(ABC) transporter
IS497_RS05615	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS497_RS05620	COG1609	Transcriptional regulator
IS497_RS05625	COG1940	carbohydrate kinase activity
IS497_RS05630	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS497_RS05635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS05640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS05645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS05650	COG4580	involved in the transport of maltose and maltodextrins
IS497_RS05660	COG2723	6-phospho-beta-galactosidase activity
IS497_RS05670	COG0309	Hydrogenase expression formation protein (HypE)
IS497_RS05675	COG0409	Hydrogenase expression formation protein
IS497_RS05680	COG0298	carbon dioxide binding
IS497_RS05685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IS497_RS05700	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS497_RS05705	COG0651	ATP synthesis coupled electron transport
IS497_RS05710	COG0650	Formate hydrogenlyase subunit 4
IS497_RS05715	COG3261	NADH dehydrogenase
IS497_RS05715	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IS497_RS05720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS497_RS05725	COG3260	NADH ubiquinone oxidoreductase 20
IS497_RS05735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IS497_RS05745	COG2723	6-phospho-beta-galactosidase activity
IS497_RS05750	COG1263	PTS System
IS497_RS05750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS05755	COG1609	Transcriptional regulator
IS497_RS05760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS497_RS05765	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IS497_RS05770	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IS497_RS05795	COG1349	DNA-binding transcription factor activity
IS497_RS05800	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS05815	COG3732	PTS system glucitol sorbitol-specific
IS497_RS05820	COG3730	PTS system glucitol sorbitol-specific
IS497_RS05825	COG2951	lytic endotransglycosylase activity
IS497_RS05830	COG1121	(ABC) transporter
IS497_RS05835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS497_RS05845	COG1546	Belongs to the CinA family
IS497_RS05865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IS497_RS05895	COG2823	Periplasmic or secreted lipoprotein
IS497_RS05900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS497_RS05905	COG1238	metal cluster binding
IS497_RS05925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IS497_RS05930	COG2814	Major facilitator Superfamily
IS497_RS05935	COG1566	PFAM secretion protein HlyD family protein
IS497_RS05940	COG1846	Transcriptional regulator
IS497_RS05950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IS497_RS05960	COG4176	ABC-type proline glycine betaine transport system permease component
IS497_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS497_RS05985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS497_RS05990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS497_RS05995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS497_RS06000	COG4575	ribosome binding
IS497_RS06015	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS497_RS06030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS497_RS06035	COG0640	Transcriptional regulator
IS497_RS06045	COG0583	DNA-binding transcription factor activity
IS497_RS06050	COG3284	Transcriptional regulator
IS497_RS06065	COG4974	Belongs to the 'phage' integrase family
IS497_RS06100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS497_RS06115	COG3344	reverse transcriptase
IS497_RS06150	COG4695	Portal protein
IS497_RS06315	COG2867	negative regulation of translational initiation
IS497_RS06330	COG0497	DNA recombination
IS497_RS06345	COG4536	flavin adenine dinucleotide binding
IS497_RS06350	COG4137	Cytochrome C assembly protein
IS497_RS06355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IS497_RS06390	COG2885	chlorophyll binding
IS497_RS06395	COG2199	diguanylate cyclase activity
IS497_RS06405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS497_RS06410	COG1605	Chorismate mutase
IS497_RS06410	COG0287	Prephenate dehydrogenase
IS497_RS06420	COG1605	Chorismate mutase
IS497_RS06420	COG0077	Prephenate dehydratase
IS497_RS06430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS497_RS06435	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS497_RS06450	COG0542	response to heat
IS497_RS06475	COG0477	Major facilitator Superfamily
IS497_RS06480	COG5544	Lipoprotein
IS497_RS06485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS497_RS06495	COG3148	PFAM DTW domain containing protein
IS497_RS06500	COG3118	belongs to the thioredoxin family
IS497_RS06505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS497_RS06520	COG0513	Belongs to the DEAD box helicase family
IS497_RS06530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IS497_RS06545	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IS497_RS06550	COG3026	antisigma factor binding
IS497_RS06555	COG3086	response to oxidative stress
IS497_RS06565	COG0681	Belongs to the peptidase S26 family
IS497_RS06585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS497_RS06595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS497_RS06600	COG1737	Transcriptional regulator
IS497_RS06605	COG0560	Phosphoserine phosphatase
IS497_RS06620	COG0047	phosphoribosylformylglycinamidine synthase activity
IS497_RS06620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IS497_RS06625	COG2205	protein histidine kinase activity
IS497_RS06630	COG3170	Tfp pilus assembly protein FimV
IS497_RS06635	COG2204	response regulator
IS497_RS06640	COG0347	Belongs to the P(II) protein family
IS497_RS06645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS497_RS06645	COG1017	nitric oxide dioxygenase activity
IS497_RS06655	COG2259	Doxx family
IS497_RS06660	COG1940	carbohydrate kinase activity
IS497_RS06665	COG0457	Tetratricopeptide repeat
IS497_RS06670	COG0477	Major facilitator Superfamily
IS497_RS06670	COG2814	Major facilitator Superfamily
IS497_RS06675	COG2017	converts alpha-aldose to the beta-anomer
IS497_RS06680	COG2814	Major facilitator Superfamily
IS497_RS06685	COG3711	transcriptional antiterminator
IS497_RS06690	COG3683	transport system, periplasmic component
IS497_RS06695	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS497_RS06730	COG0822	iron-sulfur transferase activity
IS497_RS06750	COG0633	Ferredoxin
IS497_RS06755	COG2975	iron-sulfur cluster assembly
IS497_RS06775	COG2897	thiosulfate sulfurtransferase activity
IS497_RS06780	COG2373	Large extracellular alpha-helical protein
IS497_RS06785	COG4953	penicillin-binding protein 1C
IS497_RS06815	COG2976	Protein conserved in bacteria
IS497_RS06835	COG1645	bacterial-type flagellum-dependent swarming motility
IS497_RS06845	COG0516	GMP reductase activity
IS497_RS06845	COG0517	IMP dehydrogenase activity
IS497_RS06890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS497_RS06975	COG5484	DNA packaging
IS497_RS06975	COG3728	DNA packaging
IS497_RS07070	COG3617	BRO family, N-terminal domain
IS497_RS07100	COG3179	chitinase
IS497_RS07110	COG3119	arylsulfatase activity
IS497_RS07115	COG0641	radical SAM
IS497_RS07135	COG2200	EAL domain
IS497_RS07150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IS497_RS07165	COG2723	6-phospho-beta-galactosidase activity
IS497_RS07175	COG2233	PERMEase
IS497_RS07190	COG1393	Belongs to the ArsC family
IS497_RS07195	COG4783	chaperone-mediated protein folding
IS497_RS07205	COG0628	permease
IS497_RS07210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IS497_RS07215	COG2716	regulation of RNA biosynthetic process
IS497_RS07225	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IS497_RS07235	COG2321	neutral zinc metallopeptidase
IS497_RS07240	COG1444	tRNA N-acetyltransferase activity
IS497_RS07245	COG0400	carboxylic ester hydrolase activity
IS497_RS07260	COG1393	Belongs to the ArsC family
IS497_RS07270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS497_RS07275	COG0493	'glutamate synthase
IS497_RS07275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS497_RS07285	COG5342	invasion associated locus B
IS497_RS07290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS497_RS07295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS497_RS07305	COG4810	utilization protein
IS497_RS07395	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS497_RS07415	COG2837	iron assimilation
IS497_RS07425	COG4150	thiosulfate binding
IS497_RS07430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IS497_RS07435	COG4208	sulfate ABC transporter
IS497_RS07440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IS497_RS07450	COG4319	ketosteroid isomerase
IS497_RS07485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IS497_RS07505	COG3530	Putative quorum-sensing-regulated virulence factor
IS497_RS07510	COG0385	Bile acid
IS497_RS07515	COG0583	DNA-binding transcription factor activity
IS497_RS07545	COG3415	Transposase
IS497_RS07550	COG3415	Transposase
IS497_RS07565	COG2200	EAL domain
IS497_RS07565	COG2199	diguanylate cyclase activity
IS497_RS07570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS497_RS07585	COG0667	Aldo Keto reductase
IS497_RS07590	COG3961	Belongs to the TPP enzyme family
IS497_RS07605	COG3279	Response regulator of the LytR AlgR family
IS497_RS07610	COG3275	phosphorelay sensor kinase activity
IS497_RS07625	COG0436	Aminotransferase
IS497_RS07635	COG2807	transmembrane transport
IS497_RS07640	COG0590	tRNA wobble adenosine to inosine editing
IS497_RS07645	COG0583	DNA-binding transcription factor activity
IS497_RS07665	COG2116	formate transmembrane transporter activity
IS497_RS07670	COG2853	Lipoprotein
IS497_RS07680	COG3691	Protein conserved in bacteria
IS497_RS07695	COG2062	phosphohistidine phosphatase, SixA
IS497_RS07720	COG0730	response to heat
IS497_RS07725	COG3101	peptidyl-lysine hydroxylation
IS497_RS07740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS497_RS07760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS497_RS07770	COG0586	Pfam SNARE associated Golgi protein
IS497_RS07780	COG0285	dihydrofolate synthase activity
IS497_RS07785	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IS497_RS07790	COG1286	toxin biosynthetic process
IS497_RS07795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IS497_RS07800	COG0163	prenyltransferase activity
IS497_RS07825	COG4160	amino acid transport
IS497_RS07830	COG4598	ABC transporter
IS497_RS07845	COG1090	epimerase
IS497_RS07850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS497_RS07855	COG0625	glutathione transferase activity
IS497_RS07860	COG0625	glutathione transferase activity
IS497_RS07865	COG0622	Phosphoesterase
IS497_RS07870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IS497_RS07875	COG0280	phosphate acetyltransferase
IS497_RS07875	COG0857	belongs to the CobB CobQ family
IS497_RS07895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS497_RS07900	COG0471	metal ion transport
IS497_RS07900	COG0490	domain, Protein
IS497_RS07910	COG0436	Aminotransferase
IS497_RS07915	COG0583	DNA-binding transcription factor activity
IS497_RS07960	COG0839	Belongs to the complex I subunit 6 family
IS497_RS07970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IS497_RS07975	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS497_RS07990	COG2153	protein acetylation
IS497_RS07995	COG1169	isochorismate synthase
IS497_RS08020	COG0318	PFAM AMP-dependent synthetase and ligase
IS497_RS08030	COG5464	transposase or invertase
IS497_RS08045	COG1414	Transcriptional regulator
IS497_RS08055	COG2271	Major facilitator Superfamily
IS497_RS08065	COG0247	lactate metabolic process
IS497_RS08075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS497_RS08085	COG2271	Major facilitator Superfamily
IS497_RS08090	COG0584	glycerophosphoryl diester phosphodiesterase
IS497_RS08095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS497_RS08120	COG0784	Response regulator, receiver
IS497_RS08120	COG2205	protein histidine kinase activity
IS497_RS08130	COG2198	Histidine kinase
IS497_RS08130	COG0642	Histidine kinase
IS497_RS08145	COG2169	Transcriptional regulator
IS497_RS08145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS497_RS08150	COG3145	DNA-N1-methyladenine dioxygenase activity
IS497_RS08155	COG4615	Cyclic peptide transporter
IS497_RS08160	COG2239	Acts as a magnesium transporter
IS497_RS08165	COG0659	secondary active sulfate transmembrane transporter activity
IS497_RS08180	COG0628	permease
IS497_RS08205	COG1349	DNA-binding transcription factor activity
IS497_RS08210	COG0494	nUDIX hydrolase
IS497_RS08230	COG1061	Type III restriction enzyme res subunit
IS497_RS08235	COG1187	pseudouridine synthase activity
IS497_RS08240	COG2814	Major facilitator Superfamily
IS497_RS08250	COG4172	Belongs to the ABC transporter superfamily
IS497_RS08255	COG4239	(ABC) transporter, permease
IS497_RS08260	COG4174	ABC transporter (Permease)
IS497_RS08265	COG4166	transmembrane transport
IS497_RS08270	COG2200	EAL domain
IS497_RS08275	COG0791	NLP P60 protein
IS497_RS08280	COG0671	phosphoesterase, PA-phosphatase related
IS497_RS08285	COG0523	cobalamin synthesis protein
IS497_RS08290	COG0246	Mannitol dehydrogenase
IS497_RS08295	COG1312	Catalyzes the dehydration of D-mannonate
IS497_RS08320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS08320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS08325	COG1105	Belongs to the carbohydrate kinase PfkB family
IS497_RS08330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS497_RS08330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS497_RS08330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS497_RS08340	COG2855	membrane
IS497_RS08345	COG0583	DNA-binding transcription factor activity
IS497_RS08350	COG0833	amino acid
IS497_RS08360	COG4771	TonB-dependent receptor
IS497_RS08375	COG2311	Membrane
IS497_RS08390	COG1129	ABC transporter
IS497_RS08400	COG2949	membrane
IS497_RS08410	COG1346	cytolysis
IS497_RS08420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS497_RS08425	COG3659	wide pore channel activity
IS497_RS08440	COG2723	6-phospho-beta-galactosidase activity
IS497_RS08445	COG1538	Outer membrane efflux protein
IS497_RS08450	COG0586	Pfam SNARE associated Golgi protein
IS497_RS08460	COG1686	Belongs to the peptidase S11 family
IS497_RS08475	COG0277	FAD linked oxidase domain protein
IS497_RS08480	COG1472	Belongs to the glycosyl hydrolase 3 family
IS497_RS08485	COG1732	Glycine betaine
IS497_RS08490	COG1174	glycine betaine transport
IS497_RS08495	COG1125	glycine betaine transport
IS497_RS08500	COG1174	glycine betaine transport
IS497_RS08510	COG3275	phosphorelay sensor kinase activity
IS497_RS08520	COG4807	Protein conserved in bacteria
IS497_RS08540	COG5455	response to cobalt ion
IS497_RS08545	COG0583	DNA-binding transcription factor activity
IS497_RS08550	COG2252	PERMEase
IS497_RS08560	COG0583	DNA-binding transcription factor activity
IS497_RS08575	COG0351	phosphomethylpyrimidine kinase
IS497_RS08580	COG1830	Aldolase
IS497_RS08590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS497_RS08615	COG1070	Carbohydrate kinase
IS497_RS08625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS497_RS08630	COG4948	Mandelate Racemase Muconate Lactonizing
IS497_RS08635	COG0747	negative chemotaxis
IS497_RS08640	COG0601	transmembrane transport
IS497_RS08645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS497_RS08650	COG0444	Belongs to the ABC transporter superfamily
IS497_RS08655	COG4608	Belongs to the ABC transporter superfamily
IS497_RS08665	COG0826	peptidase U32
IS497_RS08670	COG0745	RESPONSE REGULATOR receiver
IS497_RS08675	COG2205	protein histidine kinase activity
IS497_RS08700	COG1301	dicarboxylic acid transport
IS497_RS08720	COG5002	protein histidine kinase activity
IS497_RS08725	COG0443	Heat shock 70 kDa protein
IS497_RS08730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IS497_RS08745	COG2982	Protein involved in outer membrane biogenesis
IS497_RS08750	COG1253	flavin adenine dinucleotide binding
IS497_RS08805	COG1215	transferase activity, transferring glycosyl groups
IS497_RS08815	COG0438	transferase activity, transferring glycosyl groups
IS497_RS08850	COG1088	dTDP-glucose 4,6-dehydratase activity
IS497_RS08875	COG3039	Transposase
IS497_RS08925	COG0438	transferase activity, transferring glycosyl groups
IS497_RS08930	COG1215	transferase activity, transferring glycosyl groups
IS497_RS08950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IS497_RS08980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS497_RS08985	COG0583	DNA-binding transcription factor activity
IS497_RS08995	COG0531	amino acid
IS497_RS09000	COG0640	Transcriptional regulator
IS497_RS09005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS497_RS09015	COG2925	Exonuclease
IS497_RS09025	COG3344	reverse transcriptase
IS497_RS09035	COG1289	transmembrane transporter activity
IS497_RS09055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IS497_RS09065	COG1942	4-Oxalocrotonate Tautomerase
IS497_RS09070	COG0583	DNA-binding transcription factor activity
IS497_RS09075	COG0095	Lipoate-protein ligase
IS497_RS09080	COG0477	Major facilitator Superfamily
IS497_RS09090	COG3300	MHYT domain
IS497_RS09090	COG5001	Diguanylate cyclase
IS497_RS09100	COG3615	Tellurite resistance protein tehB
IS497_RS09125	COG3706	GGDEF domain
IS497_RS09175	COG2003	Belongs to the UPF0758 family
IS497_RS09220	COG3504	Conjugal transfer protein
IS497_RS09290	COG4771	TonB-dependent receptor
IS497_RS09295	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS497_RS09315	COG3433	isochorismatase activity
IS497_RS09315	COG2226	methyltransferase
IS497_RS09315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS497_RS09330	COG1132	(ABC) transporter
IS497_RS09335	COG2814	Major facilitator Superfamily
IS497_RS09340	COG1169	isochorismate synthase
IS497_RS09345	COG0582	viral genome integration into host DNA
IS497_RS09355	COG0534	Mate efflux family protein
IS497_RS09365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IS497_RS09385	COG0604	alcohol dehydrogenase
IS497_RS09395	COG0025	NhaP-type Na H and K H
IS497_RS09440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS497_RS09450	COG1418	mRNA catabolic process
IS497_RS09455	COG0270	DNA (cytosine-5-)-methyltransferase activity
IS497_RS09460	COG3727	T/G mismatch-specific endonuclease activity
IS497_RS09465	COG0697	spore germination
IS497_RS09470	COG2354	Protein conserved in bacteria
IS497_RS09500	COG0366	Alpha amylase catalytic
IS497_RS09505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS09515	COG0765	amino acid transport
IS497_RS09520	COG1126	abc transporter atp-binding protein
IS497_RS09525	COG2197	response regulator
IS497_RS09535	COG2197	response regulator
IS497_RS09570	COG3012	SEC-C Motif Domain Protein
IS497_RS09570	COG3318	Belongs to the UPF0149 family
IS497_RS09575	COG0814	amino acid
IS497_RS09585	COG1528	Iron-storage protein
IS497_RS09600	COG0477	Major facilitator Superfamily
IS497_RS09610	COG2211	Major facilitator Superfamily
IS497_RS09620	COG1528	Iron-storage protein
IS497_RS09630	COG1879	ABC-type sugar transport system periplasmic component
IS497_RS09640	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS09665	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IS497_RS09675	COG3102	Protein conserved in bacteria
IS497_RS09695	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IS497_RS09700	COG1801	Protein of unknown function DUF72
IS497_RS09705	COG1335	isochorismatase
IS497_RS09715	COG0494	nUDIX hydrolase
IS497_RS09740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS497_RS09750	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IS497_RS09755	COG0739	heme binding
IS497_RS09760	COG1560	Kdo2-lipid A biosynthetic process
IS497_RS09770	COG1737	Transcriptional regulator
IS497_RS09780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS497_RS09785	COG0129	dihydroxy-acid dehydratase activity
IS497_RS09790	COG0800	Aldolase
IS497_RS09800	COG3141	response to X-ray
IS497_RS09805	COG2979	Protein of unknown function (DUF533)
IS497_RS09810	COG1770	oligopeptidase
IS497_RS09815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS497_RS09825	COG2372	response to copper ion
IS497_RS09830	COG1276	copper resistance
IS497_RS09845	COG2990	Protein conserved in bacteria
IS497_RS09870	COG3008	intermembrane lipid transfer
IS497_RS09875	COG2995	paraquat-inducible protein a
IS497_RS09880	COG1956	GAF domain-containing protein
IS497_RS09900	COG2814	Major facilitator Superfamily
IS497_RS09905	COG1414	Transcriptional regulator
IS497_RS09935	COG0768	penicillin binding
IS497_RS09940	COG2226	methyltransferase
IS497_RS09955	COG3716	PTS system mannose fructose sorbose family IID component
IS497_RS09960	COG3715	PTS system
IS497_RS09965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS09965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS09970	COG1253	flavin adenine dinucleotide binding
IS497_RS09975	COG2200	EAL domain
IS497_RS09980	COG1760	l-serine dehydratase
IS497_RS10000	COG0251	oxidation-reduction process
IS497_RS10005	COG1199	ATP-dependent helicase activity
IS497_RS10015	COG3065	identical protein binding
IS497_RS10025	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IS497_RS10035	COG2894	cell division
IS497_RS10050	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS497_RS10080	COG2719	SpoVR family
IS497_RS10105	COG1619	proteins homologs of microcin C7 resistance protein MccF
IS497_RS10115	COG4774	siderophore transport
IS497_RS10130	COG2308	Evidence 4 Homologs of previously reported genes of
IS497_RS10170	COG0583	DNA-binding transcription factor activity
IS497_RS10175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS497_RS10190	COG1882	Formate acetyltransferase
IS497_RS10225	COG0583	DNA-binding transcription factor activity
IS497_RS10255	COG0583	DNA-binding transcription factor activity
IS497_RS10270	COG3122	Protein conserved in bacteria
IS497_RS10290	COG2885	chlorophyll binding
IS497_RS10440	COG0012	GTP binding
IS497_RS10460	COG0659	secondary active sulfate transmembrane transporter activity
IS497_RS10490	COG2890	protein-(glutamine-N5) methyltransferase activity
IS497_RS10510	COG0387	Pfam Sodium calcium exchanger
IS497_RS10515	COG4572	Cation transport regulator
IS497_RS10520	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IS497_RS10530	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IS497_RS10535	COG3707	response regulator
IS497_RS10540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS497_RS10550	COG1116	anion transmembrane transporter activity
IS497_RS10555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS497_RS10555	COG2146	nitrite reductase [NAD(P)H] activity
IS497_RS10560	COG0243	molybdopterin cofactor binding
IS497_RS10565	COG4932	domain protein
IS497_RS10570	COG2197	response regulator
IS497_RS10575	COG3850	Histidine kinase
IS497_RS10580	COG2223	nitrite transmembrane transporter activity
IS497_RS10590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS497_RS10595	COG1140	nitrate reductase beta subunit
IS497_RS10600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS497_RS10605	COG2181	nitrate reductase activity
IS497_RS10615	COG1522	sequence-specific DNA binding
IS497_RS10650	COG0788	formyltetrahydrofolate deformylase activity
IS497_RS10660	COG1752	Esterase of the alpha-beta hydrolase superfamily
IS497_RS10665	COG0745	RESPONSE REGULATOR receiver
IS497_RS10670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IS497_RS10675	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS497_RS10685	COG1435	thymidine kinase activity
IS497_RS10690	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS10690	COG1454	alcohol dehydrogenase
IS497_RS10700	COG2095	MarC family integral membrane protein
IS497_RS10705	COG4166	transmembrane transport
IS497_RS10710	COG0601	transmembrane transport
IS497_RS10715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS497_RS10720	COG0444	Belongs to the ABC transporter superfamily
IS497_RS10730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS497_RS10750	COG2353	YceI-like domain
IS497_RS10760	COG2350	Protein conserved in bacteria
IS497_RS10770	COG3001	Fructosamine kinase
IS497_RS10780	COG1105	Belongs to the carbohydrate kinase PfkB family
IS497_RS10785	COG3137	Salt-induced outer membrane protein
IS497_RS10825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS497_RS10825	COG0072	phenylalanine-tRNA ligase activity
IS497_RS10845	COG0583	DNA-binding transcription factor activity
IS497_RS10865	COG0386	Belongs to the glutathione peroxidase family
IS497_RS10875	COG0791	NLP P60 protein
IS497_RS10885	COG4256	Hemin uptake protein
IS497_RS10890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS497_RS10905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS497_RS10905	COG0574	Belongs to the PEP-utilizing enzyme family
IS497_RS10915	COG0628	permease
IS497_RS10920	COG0247	lactate metabolic process
IS497_RS10920	COG0277	FAD linked oxidase domain protein
IS497_RS10925	COG2050	protein possibly involved in aromatic compounds catabolism
IS497_RS10930	COG2261	transglycosylase associated protein
IS497_RS10955	COG1120	ATPase activity
IS497_RS10960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS10970	COG0583	DNA-binding transcription factor activity
IS497_RS10995	COG1304	FMN binding
IS497_RS11000	COG1309	transcriptional regulator
IS497_RS11020	COG0316	Belongs to the HesB IscA family
IS497_RS11025	COG0719	Fe-S assembly protein
IS497_RS11030	COG0396	ATPase activity
IS497_RS11035	COG0719	Fe-S assembly protein
IS497_RS11050	COG1376	ErfK ybiS ycfS ynhG family protein
IS497_RS11080	COG1309	transcriptional regulator
IS497_RS11085	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IS497_RS11085	COG1082	Xylose isomerase domain protein TIM barrel
IS497_RS11090	COG2271	Major facilitator Superfamily
IS497_RS11095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS497_RS11105	COG1120	ATPase activity
IS497_RS11110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS11115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS497_RS11120	COG1414	Transcriptional regulator
IS497_RS11155	COG2814	Major facilitator Superfamily
IS497_RS11175	COG0583	DNA-binding transcription factor activity
IS497_RS11180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS497_RS11200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS497_RS11205	COG1116	anion transmembrane transporter activity
IS497_RS11210	COG4774	siderophore transport
IS497_RS11215	COG1120	ATPase activity
IS497_RS11220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS11225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS11245	COG0765	amino acid transport
IS497_RS11250	COG1126	abc transporter atp-binding protein
IS497_RS11290	COG3383	formate dehydrogenase (NAD+) activity
IS497_RS11295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IS497_RS11305	COG1175	transmembrane transport
IS497_RS11335	COG4133	protoheme IX ABC transporter activity
IS497_RS11340	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS497_RS11345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS497_RS11360	COG1138	Cytochrome C-type biogenesis protein
IS497_RS11365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS497_RS11370	COG4235	cytochrome complex assembly
IS497_RS11370	COG3088	subunit of a heme lyase
IS497_RS11390	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IS497_RS11425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS497_RS11460	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS11465	COG2610	gluconate transmembrane transporter activity
IS497_RS11470	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS497_RS11480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS497_RS11490	COG0583	DNA-binding transcription factor activity
IS497_RS11515	COG0277	FAD linked oxidase domain protein
IS497_RS11520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS497_RS11545	COG0402	S-adenosylhomocysteine deaminase activity
IS497_RS11590	COG0604	alcohol dehydrogenase
IS497_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS11590	COG3321	synthase
IS497_RS11620	COG4608	Belongs to the ABC transporter superfamily
IS497_RS11625	COG0444	Belongs to the ABC transporter superfamily
IS497_RS11650	COG0346	lactoylglutathione lyase activity
IS497_RS11655	COG1349	DNA-binding transcription factor activity
IS497_RS11690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IS497_RS11740	COG0307	riboflavin synthase, alpha
IS497_RS11745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS497_RS11750	COG2814	Major facilitator Superfamily
IS497_RS11755	COG0583	DNA-binding transcription factor activity
IS497_RS11770	COG2814	Major facilitator Superfamily
IS497_RS11785	COG0791	NLP P60 protein
IS497_RS11790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS497_RS11800	COG0346	lactoylglutathione lyase activity
IS497_RS11805	COG1902	pentaerythritol trinitrate reductase activity
IS497_RS11810	COG1309	transcriptional regulator
IS497_RS11815	COG3313	Fe-S protein
IS497_RS11820	COG4989	oxidoreductase activity
IS497_RS11825	COG2032	superoxide dismutase activity
IS497_RS11830	COG1289	transmembrane transporter activity
IS497_RS11835	COG1566	PFAM secretion protein HlyD family protein
IS497_RS11850	COG3706	GGDEF domain
IS497_RS11865	COG3895	Periplasmic Protein
IS497_RS11880	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IS497_RS11885	COG0625	glutathione transferase activity
IS497_RS11895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IS497_RS11905	COG4659	FMN binding
IS497_RS11940	COG2723	6-phospho-beta-galactosidase activity
IS497_RS11950	COG0673	inositol 2-dehydrogenase activity
IS497_RS11960	COG2814	Major facilitator Superfamily
IS497_RS11980	COG3038	cytochrome b561
IS497_RS12000	COG0583	DNA-binding transcription factor activity
IS497_RS12005	COG3485	protocatechuate 3,4-dioxygenase
IS497_RS12010	COG3485	protocatechuate 3,4-dioxygenase
IS497_RS12015	COG5383	Protein conserved in bacteria
IS497_RS12020	COG2272	Belongs to the type-B carboxylesterase lipase family
IS497_RS12035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS497_RS12040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS497_RS12045	COG1275	C4-dicarboxylate transporter malic acid transport protein
IS497_RS12050	COG0500	methyltransferase
IS497_RS12065	COG3708	Transcriptional regulator
IS497_RS12065	COG2207	Transcriptional regulator
IS497_RS12070	COG3135	benzoate transporter
IS497_RS12075	COG1396	sequence-specific DNA binding
IS497_RS12085	COG0826	peptidase U32
IS497_RS12105	COG1294	oxidase, subunit
IS497_RS12110	COG1271	oxidase subunit
IS497_RS12115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS497_RS12120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS497_RS12125	COG3842	ATPase activity
IS497_RS12130	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS497_RS12135	COG1177	transmembrane transport
IS497_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS12175	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS12180	COG0747	negative chemotaxis
IS497_RS12190	COG3238	Protein conserved in bacteria
IS497_RS12195	COG1247	-acetyltransferase
IS497_RS12205	COG2130	NADP-dependent
IS497_RS12220	COG3691	Protein conserved in bacteria
IS497_RS12225	COG1228	amidohydrolase
IS497_RS12230	COG4772	TonB-dependent receptor
IS497_RS12255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS497_RS12260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS497_RS12265	COG1473	amidohydrolase
IS497_RS12270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS497_RS12275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS12285	COG0765	amino acid transport
IS497_RS12290	COG1126	abc transporter atp-binding protein
IS497_RS12300	COG0625	glutathione transferase activity
IS497_RS12335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS497_RS12340	COG3842	ATPase activity
IS497_RS12345	COG1840	ABC-type Fe3 transport system, periplasmic component
IS497_RS12350	COG1178	ABC-type Fe3 transport system permease component
IS497_RS12355	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IS497_RS12360	COG2181	nitrate reductase activity
IS497_RS12365	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS497_RS12370	COG1140	nitrate reductase beta subunit
IS497_RS12375	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS497_RS12395	COG1414	Transcriptional regulator
IS497_RS12400	COG4948	Mandelate Racemase Muconate Lactonizing
IS497_RS12405	COG4829	muconolactone delta-isomerase
IS497_RS12410	COG3485	protocatechuate 3,4-dioxygenase
IS497_RS12420	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IS497_RS12445	COG0437	4 iron, 4 sulfur cluster binding
IS497_RS12450	COG2864	formate dehydrogenase
IS497_RS12465	COG2326	polyphosphate kinase activity
IS497_RS12475	COG2814	Major facilitator Superfamily
IS497_RS12485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS497_RS12495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS497_RS12505	COG0747	negative chemotaxis
IS497_RS12510	COG1064	alcohol dehydrogenase
IS497_RS12525	COG0488	(ABC) transporter
IS497_RS12570	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS12575	COG3729	General stress protein
IS497_RS12585	COG3685	Protein conserved in bacteria
IS497_RS12595	COG0366	Alpha amylase catalytic
IS497_RS12605	COG2323	membrane
IS497_RS12615	COG3111	PFAM Bacterial OB fold (BOF) protein
IS497_RS12625	COG1764	response to oxidative stress
IS497_RS12650	COG3781	membrane
IS497_RS12655	COG0243	molybdopterin cofactor binding
IS497_RS12660	COG0583	DNA-binding transcription factor activity
IS497_RS12665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS12690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS12695	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS497_RS12700	COG2814	Major facilitator Superfamily
IS497_RS12705	COG1285	pathogenesis
IS497_RS12710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS497_RS12720	COG0583	DNA-binding transcription factor activity
IS497_RS12740	COG0519	Catalyzes the synthesis of GMP from XMP
IS497_RS12740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS497_RS12780	COG0596	Alpha beta hydrolase
IS497_RS12790	COG2205	protein histidine kinase activity
IS497_RS12805	COG0076	glutamate decarboxylase activity
IS497_RS12810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS497_RS12815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS497_RS12820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS497_RS12825	COG1116	anion transmembrane transporter activity
IS497_RS12830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IS497_RS12845	COG0673	inositol 2-dehydrogenase activity
IS497_RS12855	COG1609	Transcriptional regulator
IS497_RS12860	COG3706	GGDEF domain
IS497_RS12865	COG0402	S-adenosylhomocysteine deaminase activity
IS497_RS12870	COG1953	Uracil, thiamine, allantoin
IS497_RS12910	COG0406	alpha-ribazole phosphatase activity
IS497_RS12915	COG1335	isochorismatase
IS497_RS12945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS497_RS13015	COG0765	amino acid transport
IS497_RS13025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IS497_RS13035	COG2070	2-Nitropropane dioxygenase
IS497_RS13040	COG0583	DNA-binding transcription factor activity
IS497_RS13050	COG1902	pentaerythritol trinitrate reductase activity
IS497_RS13055	COG4529	Protein conserved in bacteria
IS497_RS13060	COG0477	Major facilitator Superfamily
IS497_RS13090	COG2223	nitrite transmembrane transporter activity
IS497_RS13100	COG1609	Transcriptional regulator
IS497_RS13105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS13115	COG3037	sugar-specific permease SgaT UlaA
IS497_RS13120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS497_RS13130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS497_RS13135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS497_RS13135	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS497_RS13135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS497_RS13150	COG0583	DNA-binding transcription factor activity
IS497_RS13155	COG0583	DNA-binding transcription factor activity
IS497_RS13160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS497_RS13170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS497_RS13185	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS13195	COG1609	Transcriptional regulator
IS497_RS13225	COG1652	LysM domain
IS497_RS13240	COG0426	domain, Protein
IS497_RS13240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS497_RS13265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IS497_RS13265	COG0456	acetyltransferase
IS497_RS13275	COG0667	Aldo Keto reductase
IS497_RS13280	COG0667	Aldo Keto reductase
IS497_RS13290	COG0667	Aldo Keto reductase
IS497_RS13310	COG4977	sequence-specific DNA binding
IS497_RS13330	COG4977	sequence-specific DNA binding
IS497_RS13335	COG1349	DNA-binding transcription factor activity
IS497_RS13350	COG1349	DNA-binding transcription factor activity
IS497_RS13355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS497_RS13360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS13365	COG0738	Major facilitator superfamily
IS497_RS13410	COG1929	Belongs to the glycerate kinase type-1 family
IS497_RS13415	COG3835	regulator
IS497_RS13435	COG2186	Transcriptional regulator
IS497_RS13440	COG1263	PTS System
IS497_RS13440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS13450	COG2814	Major facilitator Superfamily
IS497_RS13455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS13455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS13470	COG2819	hydrolase of the alpha beta superfamily
IS497_RS13475	COG5001	Diguanylate cyclase
IS497_RS13475	COG3300	MHYT domain
IS497_RS13510	COG3188	usher protein
IS497_RS13520	COG1649	PFAM Uncharacterised BCR, COG1649
IS497_RS13525	COG3550	peptidyl-serine autophosphorylation
IS497_RS13530	COG1396	sequence-specific DNA binding
IS497_RS13535	COG2351	hydroxyisourate hydrolase activity
IS497_RS13540	COG3648	Uricase
IS497_RS13540	COG3195	allantoin biosynthetic process
IS497_RS13545	COG2233	PERMEase
IS497_RS13575	COG2207	Transcriptional regulator
IS497_RS13590	COG4628	conserved protein (DUF2132)
IS497_RS13610	COG2011	ABC-type metal ion transport system permease component
IS497_RS13615	COG2070	2-Nitropropane dioxygenase
IS497_RS13625	COG0477	Major facilitator Superfamily
IS497_RS13695	COG2199	diguanylate cyclase activity
IS497_RS13710	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS13715	COG0583	DNA-binding transcription factor activity
IS497_RS13725	COG0039	L-malate dehydrogenase activity
IS497_RS13730	COG1349	DNA-binding transcription factor activity
IS497_RS13735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS497_RS13740	COG3395	kinase activity
IS497_RS13750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS497_RS13765	COG2731	YhcH YjgK YiaL family protein
IS497_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS13800	COG4977	sequence-specific DNA binding
IS497_RS13810	COG0697	spore germination
IS497_RS13815	COG2814	Major facilitator Superfamily
IS497_RS13825	COG0410	ABC transporter
IS497_RS13830	COG1129	ABC transporter
IS497_RS13845	COG0683	leucine binding
IS497_RS13850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IS497_RS13885	COG2223	nitrite transmembrane transporter activity
IS497_RS13890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IS497_RS13905	COG1349	DNA-binding transcription factor activity
IS497_RS13910	COG2084	Dehydrogenase
IS497_RS13915	COG3395	kinase activity
IS497_RS13920	COG0235	Class ii aldolase
IS497_RS13925	COG3622	Belongs to the hyi family
IS497_RS13930	COG2610	gluconate transmembrane transporter activity
IS497_RS13935	COG2207	Transcriptional regulator
IS497_RS13935	COG3708	Transcriptional regulator
IS497_RS13950	COG2200	EAL domain
IS497_RS13955	COG1546	Belongs to the CinA family
IS497_RS13960	COG0071	Belongs to the small heat shock protein (HSP20) family
IS497_RS13975	COG2197	response regulator
IS497_RS13990	COG2135	peptidase activity
IS497_RS13995	COG2207	Transcriptional regulator
IS497_RS14010	COG4221	oxidoreductase activity
IS497_RS14015	COG1802	Transcriptional regulator
IS497_RS14020	COG0589	response to stress
IS497_RS14025	COG0246	Mannitol dehydrogenase
IS497_RS14030	COG2271	Major facilitator Superfamily
IS497_RS14045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS497_RS14060	COG0243	molybdopterin cofactor binding
IS497_RS14065	COG0437	4 iron, 4 sulfur cluster binding
IS497_RS14070	COG3302	dmso reductase anchor subunit
IS497_RS14085	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IS497_RS14090	COG1940	carbohydrate kinase activity
IS497_RS14095	COG0583	DNA-binding transcription factor activity
IS497_RS14100	COG2814	Major facilitator Superfamily
IS497_RS14105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IS497_RS14115	COG3591	Belongs to the peptidase S1B family
IS497_RS14135	COG0628	permease
IS497_RS14165	COG0679	Auxin Efflux Carrier
IS497_RS14175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS497_RS14200	COG3290	protein histidine kinase activity
IS497_RS14205	COG4565	transcriptional regulatory protein
IS497_RS14225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS497_RS14225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS497_RS14235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS497_RS14240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS497_RS14250	COG0183	Belongs to the thiolase family
IS497_RS14255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS497_RS14265	COG1414	Transcriptional regulator
IS497_RS14270	COG2840	Smr protein MutS2
IS497_RS14275	COG0583	DNA-binding transcription factor activity
IS497_RS14285	COG1473	amidohydrolase
IS497_RS14290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IS497_RS14305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS497_RS14320	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IS497_RS14325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IS497_RS14340	COG0531	amino acid
IS497_RS14350	COG3136	membrane protein required for alginate biosynthesis
IS497_RS14355	COG0745	RESPONSE REGULATOR receiver
IS497_RS14365	COG2205	protein histidine kinase activity
IS497_RS14375	COG0114	fumarate hydratase activity
IS497_RS14380	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS497_RS14380	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS497_RS14385	COG1482	cell wall glycoprotein biosynthetic process
IS497_RS14390	COG5339	Protein conserved in bacteria
IS497_RS14395	COG1609	Transcriptional regulator
IS497_RS14400	COG1263	PTS System
IS497_RS14400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS14405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS497_RS14430	COG2391	methyltransferase activity
IS497_RS14435	COG0425	Belongs to the sulfur carrier protein TusA family
IS497_RS14440	COG5562	phage envelope protein
IS497_RS14445	COG0401	homolog of Blt101
IS497_RS14450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS497_RS14455	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS14465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS497_RS14470	COG0477	Major facilitator Superfamily
IS497_RS14475	COG1113	amino acid transport
IS497_RS14480	COG2988	succinylglutamate desuccinylase activity
IS497_RS14485	COG3724	N-succinylarginine dihydrolase activity
IS497_RS14490	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS14495	COG3138	arginine N-succinyltransferase
IS497_RS14500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS497_RS14510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS497_RS14515	COG0667	Aldo Keto reductase
IS497_RS14520	COG0583	DNA-binding transcription factor activity
IS497_RS14545	COG4122	O-methyltransferase activity
IS497_RS14550	COG1643	Atp-dependent helicase
IS497_RS14565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS497_RS14570	COG3327	negative regulation of DNA-templated transcription, initiation
IS497_RS14575	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IS497_RS14580	COG0183	Belongs to the thiolase family
IS497_RS14585	COG2050	protein possibly involved in aromatic compounds catabolism
IS497_RS14590	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS497_RS14595	COG1024	Enoyl-CoA hydratase
IS497_RS14600	COG1024	Enoyl-CoA hydratase
IS497_RS14605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS497_RS14610	COG2151	metal-sulfur cluster biosynthetic enzyme
IS497_RS14615	COG3396	Phenylacetate-CoA oxygenase
IS497_RS14620	COG3460	Phenylacetate-CoA oxygenase
IS497_RS14625	COG3396	Phenylacetate-CoA oxygenase
IS497_RS14630	COG2030	dehydratase
IS497_RS14630	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS14655	COG2207	Transcriptional regulator
IS497_RS14660	COG3784	Protein of unknown function (DUF1318)
IS497_RS14670	COG2911	Protein conserved in bacteria
IS497_RS14675	COG0586	Pfam SNARE associated Golgi protein
IS497_RS14680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS497_RS14685	COG3187	Heat shock protein
IS497_RS14690	COG3042	response to heat
IS497_RS14695	COG0674	pyruvate-flavodoxin oxidoreductase activity
IS497_RS14695	COG1013	pyruvate-flavodoxin oxidoreductase activity
IS497_RS14695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS497_RS14695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IS497_RS14700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS497_RS14710	COG0589	response to stress
IS497_RS14720	COG0513	Belongs to the DEAD box helicase family
IS497_RS14730	COG1349	DNA-binding transcription factor activity
IS497_RS14735	COG0673	inositol 2-dehydrogenase activity
IS497_RS14750	COG1113	amino acid transport
IS497_RS14755	COG1522	sequence-specific DNA binding
IS497_RS14765	COG1448	Aminotransferase
IS497_RS14770	COG2011	ABC-type metal ion transport system permease component
IS497_RS14785	COG0436	Aminotransferase
IS497_RS14790	COG0604	alcohol dehydrogenase
IS497_RS14820	COG0583	DNA-binding transcription factor activity
IS497_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS14845	COG1309	transcriptional regulator
IS497_RS14850	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS14945	COG2885	chlorophyll binding
IS497_RS14985	COG3344	reverse transcriptase
IS497_RS15070	COG0741	lytic transglycosylase activity
IS497_RS15070	COG1196	nuclear chromosome segregation
IS497_RS15070	COG0739	heme binding
IS497_RS15140	COG3567	Phage-associated protein, HI1409 family
IS497_RS15145	COG1783	phage Terminase large subunit
IS497_RS15165	COG3772	lysozyme
IS497_RS15175	COG0484	heat shock protein binding
IS497_RS15280	COG0582	viral genome integration into host DNA
IS497_RS15285	COG0693	protein deglycase activity
IS497_RS15290	COG1078	dGTPase activity
IS497_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS15300	COG0583	DNA-binding transcription factor activity
IS497_RS15320	COG0656	L-ascorbic acid biosynthetic process
IS497_RS15350	COG4166	transmembrane transport
IS497_RS15360	COG2866	Carboxypeptidase
IS497_RS15365	COG4948	Mandelate Racemase Muconate Lactonizing
IS497_RS15370	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IS497_RS15375	COG3180	Ammonia monooxygenase
IS497_RS15385	COG1486	melibiose metabolic process
IS497_RS15390	COG0583	DNA-binding transcription factor activity
IS497_RS15400	COG3106	COG3106 Predicted ATPase
IS497_RS15410	COG1983	PspC domain protein
IS497_RS15420	COG1842	Phage shock protein A
IS497_RS15425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS497_RS15435	COG1473	amidohydrolase
IS497_RS15450	COG0702	epimerase
IS497_RS15465	COG2135	peptidase activity
IS497_RS15475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS497_RS15480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS497_RS15485	COG3344	reverse transcriptase
IS497_RS15530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IS497_RS15645	COG4171	peptide transport system, permease
IS497_RS15660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS497_RS15670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS497_RS15675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS497_RS15675	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS497_RS15690	COG1349	DNA-binding transcription factor activity
IS497_RS15700	COG0023	Translation Initiation Factor
IS497_RS15710	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IS497_RS15715	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IS497_RS15720	COG0671	phosphoesterase, PA-phosphatase related
IS497_RS15730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IS497_RS15755	COG0616	signal peptide processing
IS497_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS15770	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IS497_RS15780	COG0583	DNA-binding transcription factor activity
IS497_RS15790	COG0009	L-threonylcarbamoyladenylate synthase
IS497_RS15800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IS497_RS15805	COG0512	Glutamine amidotransferase of anthranilate synthase
IS497_RS15805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS497_RS15810	COG0135	phosphoribosylanthranilate isomerase activity
IS497_RS15810	COG0134	indole-3-glycerol-phosphate synthase activity
IS497_RS15865	COG4774	siderophore transport
IS497_RS15875	COG3047	cAMP biosynthetic process
IS497_RS15880	COG0727	PFAM Uncharacterised protein family (UPF0153)
IS497_RS15910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS497_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS15920	COG1988	membrane-bound metal-dependent
IS497_RS15925	COG1823	symporter activity
IS497_RS15935	COG0753	catalase activity
IS497_RS15945	COG1486	melibiose metabolic process
IS497_RS15950	COG2169	Transcriptional regulator
IS497_RS15950	COG1917	Cupin 2, conserved barrel domain protein
IS497_RS15955	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS497_RS15960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS15970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS15975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS497_RS15985	COG0322	excinuclease ABC activity
IS497_RS15990	COG3678	ATP-independent chaperone mediated protein folding
IS497_RS16000	COG3724	N-succinylarginine dihydrolase activity
IS497_RS16010	COG3138	arginine N-succinyltransferase
IS497_RS16020	COG0708	Exodeoxyribonuclease III
IS497_RS16025	COG0398	Pfam SNARE associated Golgi protein
IS497_RS16030	COG0398	Pfam SNARE associated Golgi protein
IS497_RS16035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS497_RS16040	COG4134	Bacterial extracellular solute-binding protein
IS497_RS16045	COG4135	transport system, permease component
IS497_RS16050	COG4136	ATPase activity
IS497_RS16055	COG2897	thiosulfate sulfurtransferase activity
IS497_RS16060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS497_RS16065	COG0494	nUDIX hydrolase
IS497_RS16070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS497_RS16075	COG0604	alcohol dehydrogenase
IS497_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS16075	COG3321	synthase
IS497_RS16080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS497_RS16085	COG0709	Synthesizes selenophosphate from selenide and ATP
IS497_RS16100	COG0778	Nitroreductase
IS497_RS16105	COG0616	signal peptide processing
IS497_RS16110	COG0252	asparaginase activity
IS497_RS16115	COG1335	isochorismatase
IS497_RS16120	COG2814	Major facilitator Superfamily
IS497_RS16125	COG1349	DNA-binding transcription factor activity
IS497_RS16130	COG0667	Aldo Keto reductase
IS497_RS16135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS16140	COG0191	fructose-bisphosphate aldolase activity
IS497_RS16145	COG1063	alcohol dehydrogenase
IS497_RS16150	COG2271	Major facilitator Superfamily
IS497_RS16155	COG1063	alcohol dehydrogenase
IS497_RS16170	COG3139	Protein of unknown function (DUF1315)
IS497_RS16195	COG3713	MltA-interacting MipA family protein
IS497_RS16200	COG2766	serine protein kinase
IS497_RS16215	COG0386	Belongs to the glutathione peroxidase family
IS497_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS16245	COG0583	DNA-binding transcription factor activity
IS497_RS16250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS497_RS16255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS497_RS16260	COG3344	reverse transcriptase
IS497_RS16270	COG0859	PFAM glycosyl transferase family 9
IS497_RS16275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS497_RS16285	COG2207	Transcriptional regulator
IS497_RS16290	COG2807	transmembrane transport
IS497_RS16295	COG0504	CTP synthase activity
IS497_RS16300	COG1683	Conserved Protein
IS497_RS16305	COG3189	MarR family transcriptional regulator
IS497_RS16310	COG3042	response to heat
IS497_RS16315	COG2199	diguanylate cyclase activity
IS497_RS16315	COG2203	Gaf domain
IS497_RS16335	COG3182	Iron-regulated membrane protein
IS497_RS16345	COG1560	Kdo2-lipid A biosynthetic process
IS497_RS16355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IS497_RS16360	COG3706	GGDEF domain
IS497_RS16365	COG0583	DNA-binding transcription factor activity
IS497_RS16370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS497_RS16400	COG1294	oxidase, subunit
IS497_RS16405	COG1271	oxidase subunit
IS497_RS16410	COG3546	catalase activity
IS497_RS16415	COG3685	Protein conserved in bacteria
IS497_RS16420	COG3685	Protein conserved in bacteria
IS497_RS16425	COG3729	General stress protein
IS497_RS16430	COG1063	alcohol dehydrogenase
IS497_RS16435	COG3813	Protein conserved in bacteria
IS497_RS16455	COG0640	Transcriptional regulator
IS497_RS16460	COG0538	isocitrate dehydrogenase activity
IS497_RS16545	COG0616	signal peptide processing
IS497_RS16560	COG1802	Transcriptional regulator
IS497_RS16560	COG4626	Terminase
IS497_RS16605	COG3772	lysozyme
IS497_RS16630	COG1403	HNH endonuclease
IS497_RS16650	COG3344	reverse transcriptase
IS497_RS16655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IS497_RS16695	COG1396	sequence-specific DNA binding
IS497_RS16715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS497_RS16725	COG0582	viral genome integration into host DNA
IS497_RS16730	COG0538	isocitrate dehydrogenase activity
IS497_RS16750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS497_RS16755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS497_RS16760	COG3344	reverse transcriptase
IS497_RS16810	COG1196	nuclear chromosome segregation
IS497_RS16850	COG0740	serine-type endopeptidase activity
IS497_RS16925	COG1403	HNH endonuclease
IS497_RS16930	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IS497_RS16960	COG1396	sequence-specific DNA binding
IS497_RS17015	COG0582	viral genome integration into host DNA
IS497_RS17020	COG0538	isocitrate dehydrogenase activity
IS497_RS17025	COG1187	pseudouridine synthase activity
IS497_RS17045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IS497_RS17065	COG2205	protein histidine kinase activity
IS497_RS17070	COG2850	peptidyl-arginine hydroxylation
IS497_RS17090	COG1177	transmembrane transport
IS497_RS17105	COG0318	PFAM AMP-dependent synthetase and ligase
IS497_RS17115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IS497_RS17125	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS497_RS17135	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS497_RS17145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IS497_RS17150	COG1388	LysM domain
IS497_RS17150	COG1376	ErfK ybiS ycfS ynhG family protein
IS497_RS17165	COG1309	transcriptional regulator
IS497_RS17180	COG3134	Outer membrane lipoprotein
IS497_RS17185	COG1252	NADH dehydrogenase
IS497_RS17210	COG5633	Lipoprotein
IS497_RS17215	COG0537	adenosine 5'-monophosphoramidase activity
IS497_RS17225	COG0084	hydrolase, TatD family'
IS497_RS17230	COG0470	DNA polymerase III
IS497_RS17240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IS497_RS17245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS497_RS17250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS497_RS17265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS497_RS17285	COG1399	metal-binding, possibly nucleic acid-binding protein
IS497_RS17305	COG1530	ribonuclease E activity
IS497_RS17310	COG0583	DNA-binding transcription factor activity
IS497_RS17315	COG2814	Major facilitator Superfamily
IS497_RS17335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS497_RS17380	COG1560	Kdo2-lipid A biosynthetic process
IS497_RS17395	COG5645	(Lipo)protein
IS497_RS17430	COG3381	protein complex oligomerization
IS497_RS17460	COG0583	DNA-binding transcription factor activity
IS497_RS17470	COG1335	isochorismatase
IS497_RS17480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS497_RS17485	COG1702	phosphate starvation-inducible protein PhoH
IS497_RS17505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS497_RS17515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS497_RS17530	COG1309	transcriptional regulator
IS497_RS17565	COG2233	PERMEase
IS497_RS17575	COG3729	General stress protein
IS497_RS17605	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS17620	COG0531	amino acid
IS497_RS17625	COG0174	glutamine synthetase
IS497_RS17630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IS497_RS17635	COG1917	Cupin 2, conserved barrel domain protein
IS497_RS17635	COG1396	sequence-specific DNA binding
IS497_RS17640	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS17645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS497_RS17650	COG0583	DNA-binding transcription factor activity
IS497_RS17655	COG0473	3-isopropylmalate dehydrogenase activity
IS497_RS17660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS497_RS17665	COG4638	Rieske (2fe-2S)
IS497_RS17670	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS17675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS497_RS17700	COG0670	Belongs to the BI1 family
IS497_RS17715	COG2207	Transcriptional regulator
IS497_RS17720	COG1881	PFAM PEBP family protein
IS497_RS17735	COG1832	CoA-binding protein
IS497_RS17745	COG0210	DNA helicase
IS497_RS17750	COG3304	Inner membrane component domain
IS497_RS17755	COG1289	transmembrane transporter activity
IS497_RS17760	COG3070	regulator of competence-specific genes
IS497_RS17780	COG1067	ATP-dependent peptidase activity
IS497_RS17790	COG3130	regulation of translation
IS497_RS17795	COG3009	Protein conserved in bacteria
IS497_RS17800	COG3008	intermembrane lipid transfer
IS497_RS17800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS497_RS17805	COG2995	paraquat-inducible protein a
IS497_RS17810	COG0488	(ABC) transporter
IS497_RS17820	COG3217	Mosc domain protein beta barrel domain protein
IS497_RS17820	COG0633	Ferredoxin
IS497_RS17835	COG0431	NADPH-dependent FMN reductase
IS497_RS17840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS497_RS17845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS497_RS17850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS497_RS17860	COG0308	aminopeptidase N
IS497_RS17870	COG1473	amidohydrolase
IS497_RS17880	COG0814	amino acid
IS497_RS17905	COG1448	Aminotransferase
IS497_RS17910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS497_RS17915	COG3108	Peptidase M15
IS497_RS17920	COG2989	Protein conserved in bacteria
IS497_RS17930	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IS497_RS17940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS497_RS17945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS497_RS17950	COG3173	Aminoglycoside phosphotransferase
IS497_RS17965	COG3214	Protein conserved in bacteria
IS497_RS17980	COG0658	competence protein
IS497_RS17980	COG2333	competence protein COMEC
IS497_RS17990	COG0539	negative regulation of cytoplasmic translation
IS497_RS18010	COG2323	membrane
IS497_RS18015	COG1944	ATP diphosphatase activity
IS497_RS18020	COG2116	formate transmembrane transporter activity
IS497_RS18025	COG1882	Formate acetyltransferase
IS497_RS18030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS497_RS18035	COG0477	Major facilitator Superfamily
IS497_RS18040	COG3302	dmso reductase anchor subunit
IS497_RS18045	COG0437	4 iron, 4 sulfur cluster binding
IS497_RS18050	COG0243	molybdopterin cofactor binding
IS497_RS18060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IS497_RS18070	COG1674	ftsk spoiiie
IS497_RS18070	COG1178	ABC-type Fe3 transport system permease component
IS497_RS18080	COG0492	ferredoxin-NADP+ reductase activity
IS497_RS18085	COG4988	ABC transporter
IS497_RS18090	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IS497_RS18105	COG0542	response to heat
IS497_RS18115	COG1278	Cold shock
IS497_RS18125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS18130	COG3593	DNA synthesis involved in DNA repair
IS497_RS18140	COG2431	L-lysine efflux transmembrane transporter activity
IS497_RS18150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS497_RS18160	COG0028	Belongs to the TPP enzyme family
IS497_RS18165	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IS497_RS18170	COG0702	epimerase
IS497_RS18175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS497_RS18180	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS497_RS18185	COG5001	Diguanylate cyclase
IS497_RS18185	COG4251	negative regulation of phosphorylation
IS497_RS18185	COG3706	GGDEF domain
IS497_RS18185	COG2203	Gaf domain
IS497_RS18195	COG1126	abc transporter atp-binding protein
IS497_RS18200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS18205	COG4215	(ABC) transporter
IS497_RS18210	COG4160	amino acid transport
IS497_RS18215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS18220	COG5002	protein histidine kinase activity
IS497_RS18225	COG0745	RESPONSE REGULATOR receiver
IS497_RS18240	COG1177	transmembrane transport
IS497_RS18245	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS497_RS18250	COG3842	ATPase activity
IS497_RS18255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS497_RS18450	COG4695	Portal protein
IS497_RS18485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS497_RS18525	COG3344	reverse transcriptase
IS497_RS18530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS497_RS18535	COG3226	Transcriptional regulator
IS497_RS18540	COG0738	Major facilitator superfamily
IS497_RS18545	COG0561	phosphatase activity
IS497_RS18550	COG2814	Major facilitator Superfamily
IS497_RS18555	COG0671	phosphoesterase, PA-phosphatase related
IS497_RS18560	COG1349	DNA-binding transcription factor activity
IS497_RS18565	COG1686	Belongs to the peptidase S11 family
IS497_RS18575	COG0625	glutathione transferase activity
IS497_RS18580	COG2133	pyrroloquinoline quinone binding
IS497_RS18590	COG2223	nitrite transmembrane transporter activity
IS497_RS18610	COG0747	negative chemotaxis
IS497_RS18625	COG0303	'Molybdopterin
IS497_RS18630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS497_RS18635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS497_RS18640	COG1882	Formate acetyltransferase
IS497_RS18645	COG0561	phosphatase activity
IS497_RS18655	COG1609	Transcriptional regulator
IS497_RS18660	COG2271	Major facilitator Superfamily
IS497_RS18670	COG0488	(ABC) transporter
IS497_RS18675	COG2365	Tyrosine phosphatase family
IS497_RS18680	COG1376	ErfK ybiS ycfS ynhG family protein
IS497_RS18685	COG2188	Transcriptional regulator
IS497_RS18690	COG2723	6-phospho-beta-galactosidase activity
IS497_RS18695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS497_RS18700	COG1321	iron dependent repressor
IS497_RS18710	COG2194	sulfuric ester hydrolase activity
IS497_RS18715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IS497_RS18730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS18735	COG0765	amino acid transport
IS497_RS18740	COG1126	abc transporter atp-binding protein
IS497_RS18745	COG0668	transmembrane transport
IS497_RS18755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS497_RS18765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS497_RS18775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS497_RS18780	COG1199	ATP-dependent helicase activity
IS497_RS18785	COG0513	Belongs to the DEAD box helicase family
IS497_RS18790	COG3958	Transketolase
IS497_RS18795	COG3959	Transketolase, thiamine diphosphate binding domain
IS497_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS18805	COG2271	Major facilitator Superfamily
IS497_RS18815	COG0583	DNA-binding transcription factor activity
IS497_RS18820	COG1309	transcriptional regulator
IS497_RS18825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS18830	COG1131	(ABC) transporter
IS497_RS18835	COG0842	Transport permease protein
IS497_RS18840	COG0842	Transport permease protein
IS497_RS18850	COG3568	Endonuclease Exonuclease Phosphatase
IS497_RS18855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS497_RS18860	COG0392	lysyltransferase activity
IS497_RS18865	COG0670	Belongs to the BI1 family
IS497_RS18870	COG0314	molybdopterin synthase activity
IS497_RS18875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IS497_RS18885	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS497_RS18905	COG0745	RESPONSE REGULATOR receiver
IS497_RS18910	COG0642	Histidine kinase
IS497_RS18935	COG2226	methyltransferase
IS497_RS18950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS497_RS18955	COG1881	PFAM PEBP family protein
IS497_RS18995	COG4677	pectinesterase activity
IS497_RS19030	COG0789	Transcriptional regulator
IS497_RS19035	COG2200	EAL domain
IS497_RS19060	COG0561	phosphatase activity
IS497_RS19065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IS497_RS19070	COG4149	molybdate abc transporter
IS497_RS19075	COG0725	ABC transporter, periplasmic molybdate-binding protein
IS497_RS19085	COG3585	molybdate ion transport
IS497_RS19085	COG2005	Transcriptional regulator
IS497_RS19090	COG1119	ATPase activity
IS497_RS19100	COG1085	galactose-1-phosphate uridylyltransferase
IS497_RS19110	COG2017	converts alpha-aldose to the beta-anomer
IS497_RS19120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS497_RS19135	COG3201	nicotinamide mononucleotide transporter
IS497_RS19140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IS497_RS19180	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IS497_RS19185	COG2885	chlorophyll binding
IS497_RS19195	COG3064	Membrane
IS497_RS19200	COG0848	biopolymer transport protein
IS497_RS19205	COG0811	peptide transport
IS497_RS19210	COG0824	Thioesterase
IS497_RS19215	COG3790	cyd operon protein YbgE
IS497_RS19220	COG4890	Cyd operon protein YbgT
IS497_RS19225	COG1294	oxidase, subunit
IS497_RS19230	COG1271	oxidase subunit
IS497_RS19235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS497_RS19245	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS497_RS19250	COG0567	Dehydrogenase, E1 component
IS497_RS19255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS497_RS19260	COG1053	succinate dehydrogenase
IS497_RS19265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IS497_RS19270	COG2009	succinate dehydrogenase
IS497_RS19305	COG1984	allophanate hydrolase subunit 2
IS497_RS19310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IS497_RS19325	COG0415	Belongs to the DNA photolyase family
IS497_RS19355	COG2205	protein histidine kinase activity
IS497_RS19360	COG0745	RESPONSE REGULATOR receiver
IS497_RS19370	COG0033	Phosphoglucomutase
IS497_RS19380	COG0596	Alpha beta hydrolase
IS497_RS19395	COG0735	belongs to the Fur family
IS497_RS19435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IS497_RS19440	COG1940	carbohydrate kinase activity
IS497_RS19440	COG1846	Transcriptional regulator
IS497_RS19445	COG0647	UMP catabolic process
IS497_RS19450	COG0367	asparagine synthase
IS497_RS19490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS497_RS19500	COG1702	phosphate starvation-inducible protein PhoH
IS497_RS19510	COG4535	Mg2 and Co2 transporter CorC
IS497_RS19525	COG0765	amino acid transport
IS497_RS19530	COG0765	amino acid transport
IS497_RS19535	COG1126	abc transporter atp-binding protein
IS497_RS19550	COG2888	peptidyl-tyrosine sulfation
IS497_RS19565	COG1466	dna polymerase III delta subunit
IS497_RS19580	COG0799	negative regulation of ribosome biogenesis
IS497_RS19590	COG0768	penicillin binding
IS497_RS19595	COG0772	Belongs to the SEDS family
IS497_RS19600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS497_RS19605	COG1686	Belongs to the peptidase S11 family
IS497_RS19620	COG0583	DNA-binding transcription factor activity
IS497_RS19635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS497_RS19655	COG3069	C4-dicarboxylate transmembrane transporter activity
IS497_RS19660	COG3719	Belongs to the RNase T2 family
IS497_RS19665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS497_RS19685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS497_RS19690	COG0583	DNA-binding transcription factor activity
IS497_RS19695	COG3969	phosphoadenosine phosphosulfate
IS497_RS19700	COG1475	DNA binding
IS497_RS19705	COG0436	Aminotransferase
IS497_RS19730	COG1129	ABC transporter
IS497_RS19735	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS19740	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS19750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS497_RS19765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS497_RS19775	COG0402	S-adenosylhomocysteine deaminase activity
IS497_RS19785	COG0483	inositol monophosphate 1-phosphatase activity
IS497_RS19790	COG2271	Major facilitator Superfamily
IS497_RS19820	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS19825	COG1129	ABC transporter
IS497_RS19830	COG0371	Dehydrogenase
IS497_RS19835	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS19850	COG2879	small protein
IS497_RS19855	COG1966	Carbon starvation protein
IS497_RS19865	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS19870	COG3433	isochorismatase activity
IS497_RS19870	COG1535	isochorismatase
IS497_RS19875	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS497_RS19880	COG1169	isochorismate synthase
IS497_RS19885	COG4592	Periplasmic binding protein
IS497_RS19895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS19900	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS19905	COG1120	ATPase activity
IS497_RS19910	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IS497_RS19910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS497_RS19915	COG3251	PFAM MbtH domain protein
IS497_RS19920	COG2382	esterase
IS497_RS19925	COG4771	TonB-dependent receptor
IS497_RS19930	COG2977	Belongs to the P-Pant transferase superfamily
IS497_RS19935	COG3958	Transketolase
IS497_RS19940	COG3959	Transketolase, thiamine diphosphate binding domain
IS497_RS19945	COG2390	Transcriptional regulator
IS497_RS19950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS497_RS19955	COG1879	ABC-type sugar transport system periplasmic component
IS497_RS19965	COG1129	ABC transporter
IS497_RS19970	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS19980	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS19990	COG0583	DNA-binding transcription factor activity
IS497_RS19995	COG0668	transmembrane transport
IS497_RS20005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS497_RS20030	COG0747	negative chemotaxis
IS497_RS20035	COG0601	transmembrane transport
IS497_RS20040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS497_RS20045	COG0444	Belongs to the ABC transporter superfamily
IS497_RS20050	COG4608	Belongs to the ABC transporter superfamily
IS497_RS20055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS497_RS20060	COG4221	oxidoreductase activity
IS497_RS20070	COG4215	(ABC) transporter
IS497_RS20075	COG0765	amino acid transport
IS497_RS20080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IS497_RS20095	COG0697	spore germination
IS497_RS20105	COG3698	Phosphodiester glycosidase
IS497_RS20150	COG2315	Protein conserved in bacteria
IS497_RS20155	COG0778	Nitroreductase
IS497_RS20165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS20175	COG3716	PTS system mannose fructose sorbose family IID component
IS497_RS20180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS497_RS20185	COG2222	sugar isomerase
IS497_RS20190	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS497_RS20190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS497_RS20205	COG0477	Major facilitator Superfamily
IS497_RS20210	COG0668	transmembrane transport
IS497_RS20240	COG3188	usher protein
IS497_RS20255	COG2771	luxR family
IS497_RS20265	COG0673	inositol 2-dehydrogenase activity
IS497_RS20275	COG2211	Major facilitator Superfamily
IS497_RS20280	COG1113	amino acid transport
IS497_RS20295	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS20300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS497_RS20310	COG0531	amino acid
IS497_RS20355	COG0667	Aldo Keto reductase
IS497_RS20360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS20365	COG1473	amidohydrolase
IS497_RS20395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS20400	COG1120	ATPase activity
IS497_RS20405	COG1566	PFAM secretion protein HlyD family protein
IS497_RS20450	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS20455	COG1129	ABC transporter
IS497_RS20470	COG0673	inositol 2-dehydrogenase activity
IS497_RS20500	COG3104	oligopeptide transport
IS497_RS20505	COG1982	Orn Lys Arg decarboxylase major
IS497_RS20510	COG0531	amino acid
IS497_RS20515	COG3710	Transcriptional regulator
IS497_RS20525	COG1560	Kdo2-lipid A biosynthetic process
IS497_RS20540	COG3188	usher protein
IS497_RS20545	COG3121	Chaperone
IS497_RS20550	COG3539	Fimbrial protein
IS497_RS20600	COG2501	S4 domain
IS497_RS20610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS497_RS20625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IS497_RS20630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IS497_RS20650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IS497_RS20655	COG4181	ATPase activity
IS497_RS20660	COG2755	lipolytic protein G-D-S-L family
IS497_RS20665	COG0300	oxidoreductase activity
IS497_RS20670	COG3118	belongs to the thioredoxin family
IS497_RS20675	COG0390	transport system, permease component
IS497_RS20680	COG4619	ABC transporter
IS497_RS20685	COG0330	HflC and HflK could
IS497_RS20690	COG1585	Membrane protein implicated in regulation of membrane protease activity
IS497_RS20705	COG3735	TraB family
IS497_RS20710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS497_RS20720	COG2223	nitrite transmembrane transporter activity
IS497_RS20725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS497_RS20725	COG4651	solute:proton antiporter activity
IS497_RS20730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS20770	COG2832	Protein of unknown function (DUF454)
IS497_RS20775	COG3923	Primosomal replication protein n
IS497_RS20785	COG5464	transposase or invertase
IS497_RS20790	COG1196	nuclear chromosome segregation
IS497_RS20790	COG3264	Mechanosensitive ion channel
IS497_RS20810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS20815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS497_RS20830	COG0110	maltose O-acetyltransferase activity
IS497_RS20880	COG1874	Beta-galactosidase
IS497_RS20885	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IS497_RS20890	COG3833	ABC-type maltose transport systems, permease component
IS497_RS20895	COG1175	transmembrane transport
IS497_RS20900	COG2182	Extracellular solute-binding protein
IS497_RS20910	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS497_RS20925	COG2364	Membrane
IS497_RS20955	COG3695	enzyme binding
IS497_RS20960	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IS497_RS20965	COG1946	Acyl-CoA thioesterase
IS497_RS20970	COG0004	ammonium transporteR
IS497_RS20975	COG0347	Belongs to the P(II) protein family
IS497_RS20980	COG1132	(ABC) transporter
IS497_RS20985	COG1132	(ABC) transporter
IS497_RS20990	COG1522	sequence-specific DNA binding
IS497_RS21005	COG4533	DNA binding
IS497_RS21015	COG0824	Thioesterase
IS497_RS21020	COG1555	photosystem II stabilization
IS497_RS21025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS497_RS21030	COG0776	regulation of translation
IS497_RS21035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IS497_RS21055	COG0271	Belongs to the BolA IbaG family
IS497_RS21060	COG3056	Lipoprotein
IS497_RS21065	COG2223	nitrite transmembrane transporter activity
IS497_RS21070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS497_RS21075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS497_RS21080	COG1845	cytochrome c oxidase, subunit III
IS497_RS21085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IS497_RS21100	COG1414	Transcriptional regulator
IS497_RS21105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS497_RS21110	COG1053	succinate dehydrogenase
IS497_RS21120	COG1053	succinate dehydrogenase
IS497_RS21135	COG0673	inositol 2-dehydrogenase activity
IS497_RS21140	COG2814	Major facilitator Superfamily
IS497_RS21150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IS497_RS21155	COG0693	protein deglycase activity
IS497_RS21175	COG0142	geranyltranstransferase activity
IS497_RS21185	COG0667	Aldo Keto reductase
IS497_RS21190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IS497_RS21210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS497_RS21210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS497_RS21220	COG4238	major outer membrane lipoprotein
IS497_RS21240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS497_RS21245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS497_RS21250	COG1862	Preprotein translocase
IS497_RS21275	COG0450	alkyl hydroperoxide reductase
IS497_RS21285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS21300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS21310	COG1228	amidohydrolase
IS497_RS21320	COG1335	isochorismatase
IS497_RS21325	COG0583	DNA-binding transcription factor activity
IS497_RS21330	COG0366	Alpha amylase catalytic
IS497_RS21355	COG0420	3'-5' exonuclease activity
IS497_RS21360	COG0419	ATPase involved in DNA repair
IS497_RS21365	COG1940	carbohydrate kinase activity
IS497_RS21380	COG4126	flavin adenine dinucleotide binding
IS497_RS21390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS497_RS21395	COG3416	Protein conserved in bacteria
IS497_RS21405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IS497_RS21415	COG1785	Belongs to the alkaline phosphatase family
IS497_RS21455	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IS497_RS21460	COG1335	isochorismatase
IS497_RS21465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IS497_RS21470	COG0113	porphobilinogen synthase activity
IS497_RS21480	COG2175	clavaminate synthase activity
IS497_RS21485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS497_RS21490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IS497_RS21495	COG4521	taurine ABC transporter
IS497_RS21500	COG2040	homocysteine
IS497_RS21505	COG0833	amino acid
IS497_RS21520	COG4303	Ethanolamine ammonia lyase large subunit
IS497_RS21525	COG4302	ethanolamine ammonia-lyase activity
IS497_RS21565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS21570	COG1126	abc transporter atp-binding protein
IS497_RS21575	COG0765	amino acid transport
IS497_RS21580	COG0765	amino acid transport
IS497_RS21595	COG3188	usher protein
IS497_RS21620	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IS497_RS21630	COG3639	organic phosphonate transmembrane transporter activity
IS497_RS21650	COG0791	NLP P60 protein
IS497_RS21675	COG0582	viral genome integration into host DNA
IS497_RS21680	COG1192	Involved in chromosome partitioning
IS497_RS21740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IS497_RS21745	COG0022	dehydrogenase e1 component
IS497_RS21750	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS497_RS21755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS497_RS21775	COG1070	Carbohydrate kinase
IS497_RS21780	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS21785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS497_RS21790	COG3775	system Galactitol-specific IIC component
IS497_RS21795	COG0625	glutathione transferase activity
IS497_RS21800	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IS497_RS21815	COG0579	oxidoreductase
IS497_RS21820	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS21825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS497_RS21830	COG1113	amino acid transport
IS497_RS21835	COG1802	Transcriptional regulator
IS497_RS21855	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS497_RS21860	COG0454	-acetyltransferase
IS497_RS21875	COG2991	Protein conserved in bacteria
IS497_RS21890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS497_RS21895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS497_RS21910	COG3034	peptidoglycan biosynthetic process
IS497_RS21915	COG0121	glutamine amidotransferase
IS497_RS21925	COG1960	acyl-CoA dehydrogenase activity
IS497_RS21930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS497_RS21940	COG0583	DNA-binding transcription factor activity
IS497_RS21950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS497_RS21960	COG2226	methyltransferase
IS497_RS21970	COG0741	lytic transglycosylase activity
IS497_RS21970	COG1388	LysM domain
IS497_RS21975	COG2226	methyltransferase
IS497_RS21985	COG2814	Major facilitator Superfamily
IS497_RS21990	COG0583	DNA-binding transcription factor activity
IS497_RS21995	COG0656	L-ascorbic acid biosynthetic process
IS497_RS22030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS497_RS22040	COG2011	ABC-type metal ion transport system permease component
IS497_RS22045	COG1464	Belongs to the NlpA lipoprotein family
IS497_RS22055	COG1720	tRNA m6t6A37 methyltransferase activity
IS497_RS22065	COG0791	NLP P60 protein
IS497_RS22070	COG3015	lipoprotein NlpE involved in copper resistance
IS497_RS22075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IS497_RS22090	COG4568	rho-dependent transcription termination
IS497_RS22100	COG0346	lactoylglutathione lyase activity
IS497_RS22105	COG1982	Orn Lys Arg decarboxylase major
IS497_RS22145	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IS497_RS22155	COG0750	zinc metalloprotease
IS497_RS22160	COG0575	Belongs to the CDS family
IS497_RS22170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IS497_RS22195	COG0024	Methionine aminopeptidase
IS497_RS22200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IS497_RS22215	COG3835	regulator
IS497_RS22220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS497_RS22240	COG2860	membrane
IS497_RS22260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS22265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS497_RS22270	COG1120	ATPase activity
IS497_RS22280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS497_RS22375	COG1643	Atp-dependent helicase
IS497_RS22380	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IS497_RS22400	COG0617	tRNA 3'-terminal CCA addition
IS497_RS22405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS497_RS22425	COG0726	polysaccharide deacetylase
IS497_RS22430	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS22435	COG0842	Transport permease protein
IS497_RS22440	COG1131	(ABC) transporter
IS497_RS22445	COG0288	reversible hydration of carbon dioxide
IS497_RS22460	COG4993	Dehydrogenase
IS497_RS22465	COG2132	Multicopper oxidase
IS497_RS22515	COG3064	Membrane
IS497_RS22530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS497_RS22535	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS497_RS22540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IS497_RS22545	COG2186	Transcriptional regulator
IS497_RS22550	COG1113	amino acid transport
IS497_RS22555	COG2211	Major facilitator Superfamily
IS497_RS22560	COG3940	Belongs to the glycosyl hydrolase 43 family
IS497_RS22565	COG3725	Membrane protein required for beta-lactamase induction
IS497_RS22570	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS497_RS22580	COG4969	Belongs to the N-Me-Phe pilin family
IS497_RS22585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS497_RS22590	COG1459	type II secretion system
IS497_RS22615	COG0494	nUDIX hydrolase
IS497_RS22635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IS497_RS22640	COG0849	cell division
IS497_RS22665	COG0772	Belongs to the SEDS family
IS497_RS22680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IS497_RS22685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IS497_RS22690	COG0768	penicillin binding
IS497_RS22710	COG1609	Transcriptional regulator
IS497_RS22720	COG0028	Belongs to the TPP enzyme family
IS497_RS22765	COG0738	Major facilitator superfamily
IS497_RS22775	COG0583	DNA-binding transcription factor activity
IS497_RS22780	COG2271	Major facilitator Superfamily
IS497_RS22785	COG2814	Major facilitator Superfamily
IS497_RS22805	COG1178	ABC-type Fe3 transport system permease component
IS497_RS22815	COG0586	Pfam SNARE associated Golgi protein
IS497_RS22835	COG0235	Class ii aldolase
IS497_RS22840	COG0417	DNA replication proofreading
IS497_RS22850	COG0564	pseudouridine synthase activity
IS497_RS22860	COG3493	citrate carrier protein
IS497_RS22875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS497_RS22880	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IS497_RS22890	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS497_RS22935	COG0505	Belongs to the CarA family
IS497_RS23000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IS497_RS23025	COG1047	Peptidyl-prolyl cis-trans
IS497_RS23040	COG0196	riboflavin kinase activity
IS497_RS23050	COG0583	DNA-binding transcription factor activity
IS497_RS23075	COG4735	regulation of single-species biofilm formation
IS497_RS23080	COG1584	GPR1 FUN34 yaaH family protein
IS497_RS23085	COG0477	Major facilitator Superfamily
IS497_RS23090	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS497_RS23095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS497_RS23100	COG1115	amino acid carrier protein
IS497_RS23115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IS497_RS23125	COG0527	aspartate kinase activity
IS497_RS23125	COG0460	homoserine dehydrogenase
IS497_RS23135	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IS497_RS23145	COG0745	RESPONSE REGULATOR receiver
IS497_RS23150	COG4452	Inner membrane protein CreD
IS497_RS23155	COG2205	protein histidine kinase activity
IS497_RS23160	COG0745	RESPONSE REGULATOR receiver
IS497_RS23165	COG3045	CreA protein
IS497_RS23170	COG3708	Transcriptional regulator
IS497_RS23170	COG2207	Transcriptional regulator
IS497_RS23190	COG0741	lytic transglycosylase activity
IS497_RS23195	COG0488	(ABC) transporter
IS497_RS23205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IS497_RS23210	COG0560	Phosphoserine phosphatase
IS497_RS23215	COG3726	membrane protein affecting hemolysin expression
IS497_RS23245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS497_RS23250	COG0084	hydrolase, TatD family'
IS497_RS23255	COG4667	esterase of the alpha-beta hydrolase superfamily
IS497_RS23265	COG2823	Periplasmic or secreted lipoprotein
IS497_RS23275	COG1011	Hydrolase
IS497_RS23280	COG0456	acetyltransferase
IS497_RS23285	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IS497_RS23320	COG3706	GGDEF domain
IS497_RS23325	COG4114	ferric iron reductase
IS497_RS23330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS23330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS23335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS497_RS23340	COG2197	response regulator
IS497_RS23345	COG2197	response regulator
IS497_RS23360	COG2966	Psort location CytoplasmicMembrane, score
IS497_RS23375	COG1484	DNA-dependent DNA replication
IS497_RS23390	COG5464	transposase or invertase
IS497_RS23400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS497_RS23405	COG3716	PTS system mannose fructose sorbose family IID component
IS497_RS23410	COG3715	PTS system
IS497_RS23425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS497_RS23425	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS497_RS23435	COG1063	alcohol dehydrogenase
IS497_RS23440	COG1802	Transcriptional regulator
IS497_RS23445	COG2271	Major facilitator Superfamily
IS497_RS23450	COG0456	acetyltransferase
IS497_RS23450	COG1214	PFAM Peptidase M22, glycoprotease
IS497_RS23460	COG1737	Transcriptional regulator
IS497_RS23465	COG0800	Aldolase
IS497_RS23470	COG3734	2-keto-3-deoxy-galactonokinase
IS497_RS23485	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IS497_RS23515	COG1846	Transcriptional regulator
IS497_RS23525	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS497_RS23535	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS23540	COG3384	dioxygenase
IS497_RS23550	COG3971	2-oxopent-4-enoate hydratase activity
IS497_RS23570	COG2368	4-hydroxyphenylacetate
IS497_RS23575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS497_RS23590	COG1966	Carbon starvation protein
IS497_RS23595	COG2879	small protein
IS497_RS23600	COG0523	cobalamin synthesis protein
IS497_RS23610	COG1012	belongs to the aldehyde dehydrogenase family
IS497_RS23615	COG5464	transposase or invertase
IS497_RS23620	COG1917	Cupin 2, conserved barrel domain protein
IS497_RS23620	COG2207	Transcriptional regulator
IS497_RS23630	COG2733	membrane
IS497_RS23645	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IS497_RS23650	COG1924	4 iron, 4 sulfur cluster binding
IS497_RS23665	COG1566	PFAM secretion protein HlyD family protein
IS497_RS23675	COG5457	Domain of unknown function (DUF1127)
IS497_RS23680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS497_RS23690	COG0583	DNA-binding transcription factor activity
IS497_RS23695	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS497_RS23705	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS23710	COG1129	ABC transporter
IS497_RS23715	COG1879	ABC-type sugar transport system periplasmic component
IS497_RS23725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS23730	COG1129	ABC transporter
IS497_RS23730	COG0842	Transport permease protein
IS497_RS23735	COG0842	Transport permease protein
IS497_RS23765	COG2850	peptidyl-arginine hydroxylation
IS497_RS23780	COG5002	protein histidine kinase activity
IS497_RS23785	COG0745	RESPONSE REGULATOR receiver
IS497_RS23790	COG1538	Outer membrane efflux protein
IS497_RS23795	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS23800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS23805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS497_RS23815	COG3040	lipid binding
IS497_RS23820	COG0789	Transcriptional regulator
IS497_RS23830	COG0300	oxidoreductase activity
IS497_RS23845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS497_RS23865	COG3272	Protein of unknown function (DUF1722)
IS497_RS23870	COG4580	involved in the transport of maltose and maltodextrins
IS497_RS23880	COG2211	Major facilitator Superfamily
IS497_RS23885	COG3507	Belongs to the glycosyl hydrolase 43 family
IS497_RS23980	COG3039	Transposase
IS497_RS23990	COG0582	viral genome integration into host DNA
IS497_RS24000	COG0288	reversible hydration of carbon dioxide
IS497_RS24005	COG0659	secondary active sulfate transmembrane transporter activity
IS497_RS24010	COG1064	alcohol dehydrogenase
IS497_RS24015	COG1175	transmembrane transport
IS497_RS24020	COG0395	ABC-type sugar transport system, permease component
IS497_RS24025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS497_RS24030	COG3842	ATPase activity
IS497_RS24035	COG1653	transport
IS497_RS24045	COG1082	Xylose isomerase domain protein TIM barrel
IS497_RS24055	COG3962	Belongs to the TPP enzyme family
IS497_RS24060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS24065	COG0837	glucose binding
IS497_RS24065	COG1737	Transcriptional regulator
IS497_RS24070	COG3718	enzyme involved in inositol metabolism
IS497_RS24085	COG0433	COG0433 Predicted ATPase
IS497_RS24090	COG0795	lipopolysaccharide-transporting ATPase activity
IS497_RS24095	COG0795	lipopolysaccharide-transporting ATPase activity
IS497_RS24105	COG2927	DNA polymerase III (CHI subunit)
IS497_RS24110	COG0525	valine-tRNA ligase activity
IS497_RS24135	COG2188	Transcriptional regulator
IS497_RS24140	COG1288	antiporter activity
IS497_RS24145	COG1228	amidohydrolase
IS497_RS24150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS24155	COG2222	sugar isomerase
IS497_RS24160	COG2731	YhcH YjgK YiaL family protein
IS497_RS24195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS497_RS24195	COG1263	PTS System
IS497_RS24200	COG0366	Alpha amylase catalytic
IS497_RS24205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS497_RS24210	COG1486	melibiose metabolic process
IS497_RS24235	COG0602	queuosine metabolic process
IS497_RS24240	COG2026	Addiction module toxin, RelE StbE family
IS497_RS24245	COG3077	Addiction module antitoxin, RelB DinJ family
IS497_RS24250	COG3711	transcriptional antiterminator
IS497_RS24250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS497_RS24255	COG2706	6-phosphogluconolactonase activity
IS497_RS24270	COG3964	amidohydrolase
IS497_RS24310	COG0312	modulator of DNA gyrase
IS497_RS24335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS497_RS24345	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS24350	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS24355	COG1129	ABC transporter
IS497_RS24360	COG1879	ABC-type sugar transport system periplasmic component
IS497_RS24380	COG2105	PFAM AIG2 family protein
IS497_RS24385	COG2911	Protein conserved in bacteria
IS497_RS24390	COG0729	surface antigen
IS497_RS24400	COG1253	flavin adenine dinucleotide binding
IS497_RS24415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IS497_RS24430	COG1733	regulation of RNA biosynthetic process
IS497_RS24435	COG0702	epimerase
IS497_RS24445	COG0697	spore germination
IS497_RS24455	COG1113	amino acid transport
IS497_RS24460	COG0545	Peptidyl-prolyl cis-trans isomerase
IS497_RS24465	COG3061	Opacity-associated protein A
IS497_RS24475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IS497_RS24480	COG2965	DNA replication, synthesis of RNA primer
IS497_RS24540	COG1073	alpha beta
IS497_RS24545	COG3650	response to hydrogen peroxide
IS497_RS24555	COG1960	acyl-CoA dehydrogenase activity
IS497_RS24560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS497_RS24565	COG0557	exoribonuclease II activity
IS497_RS24580	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IS497_RS24590	COG0330	HflC and HflK could
IS497_RS24595	COG0330	HflC and HflK could
IS497_RS24600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS497_RS24620	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS497_RS24625	COG0802	atpase or kinase
IS497_RS24630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IS497_RS24630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IS497_RS24635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS497_RS24655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS497_RS24675	COG1511	domain protein
IS497_RS24675	COG3264	Mechanosensitive ion channel
IS497_RS24690	COG1053	succinate dehydrogenase
IS497_RS24695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS497_RS24715	COG2076	Multidrug Resistance protein
IS497_RS24720	COG5510	response to toxic substance
IS497_RS24735	COG1509	lysine 2,3-aminomutase activity
IS497_RS24810	COG0531	amino acid
IS497_RS24815	COG3030	protein affecting phage T7 exclusion by the F plasmid
IS497_RS24820	COG1027	Aspartate ammonia-lyase
IS497_RS24825	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS497_RS24840	COG1309	transcriptional regulator
IS497_RS24870	COG0457	Tetratricopeptide repeat
IS497_RS24875	COG1649	PFAM Uncharacterised BCR, COG1649
IS497_RS24875	COG0726	polysaccharide deacetylase
IS497_RS24880	COG1215	transferase activity, transferring glycosyl groups
IS497_RS24895	COG0861	Integral membrane protein TerC family
IS497_RS24940	COG1486	melibiose metabolic process
IS497_RS24945	COG2169	Transcriptional regulator
IS497_RS24955	COG2824	Alkylphosphonate utilization operon protein PhnA
IS497_RS24960	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IS497_RS24965	COG2188	Transcriptional regulator
IS497_RS24970	COG3624	Phosphonate C-P lyase system protein PhnG
IS497_RS24975	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IS497_RS24980	COG3626	phosphonate metabolism
IS497_RS24985	COG3627	carbon phosphorus lyase activity
IS497_RS24990	COG4107	phosphonate C-P lyase system protein PhnK
IS497_RS24995	COG4778	phosphonate C-P lyase system protein PhnL
IS497_RS25000	COG3454	Phosphonate metabolism
IS497_RS25010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IS497_RS25020	COG4191	Histidine kinase
IS497_RS25020	COG0784	Response regulator, receiver
IS497_RS25025	COG1129	ABC transporter
IS497_RS25030	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS25065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IS497_RS25070	COG1301	dicarboxylic acid transport
IS497_RS25080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS497_RS25085	COG3162	membrane
IS497_RS25115	COG3539	Fimbrial protein
IS497_RS25120	COG1346	cytolysis
IS497_RS25125	COG1380	Effector of murein hydrolase LrgA
IS497_RS25130	COG0583	DNA-binding transcription factor activity
IS497_RS25135	COG0025	NhaP-type Na H and K H
IS497_RS25140	COG2252	PERMEase
IS497_RS25145	COG0625	glutathione transferase activity
IS497_RS25150	COG0789	Transcriptional regulator
IS497_RS25160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS497_RS25190	COG1234	tRNA 3'-trailer cleavage
IS497_RS25195	COG1609	Transcriptional regulator
IS497_RS25200	COG0483	inositol monophosphate 1-phosphatase activity
IS497_RS25235	COG2315	Protein conserved in bacteria
IS497_RS25240	COG0432	Pfam Uncharacterised protein family UPF0047
IS497_RS25255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IS497_RS25260	COG0305	Participates in initiation and elongation during chromosome replication
IS497_RS25275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS497_RS25285	COG0735	belongs to the Fur family
IS497_RS25290	COG3237	CsbD-like
IS497_RS25300	COG0534	Mate efflux family protein
IS497_RS25310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IS497_RS25380	COG0251	oxidation-reduction process
IS497_RS25390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IS497_RS25400	COG0527	aspartate kinase activity
IS497_RS25455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS497_RS25485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IS497_RS25495	COG0456	acetyltransferase
IS497_RS25525	COG0151	Belongs to the GarS family
IS497_RS25535	COG4191	Histidine kinase
IS497_RS25540	COG3678	ATP-independent chaperone mediated protein folding
IS497_RS25575	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IS497_RS25590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS497_RS25595	COG2104	thiamine diphosphate biosynthetic process
IS497_RS25610	COG3706	GGDEF domain
IS497_RS25620	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS497_RS25625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS497_RS25660	COG0250	Participates in transcription elongation, termination and antitermination
IS497_RS25705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IS497_RS25735	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IS497_RS25745	COG1739	Uncharacterized protein family UPF0029
IS497_RS25785	COG0805	protein transport
IS497_RS25805	COG3165	ubiquinone biosynthetic process from chorismate
IS497_RS25835	COG0583	DNA-binding transcription factor activity
IS497_RS25840	COG0697	spore germination
IS497_RS25845	COG0561	phosphatase activity
IS497_RS25850	COG2267	carboxylic ester hydrolase activity
IS497_RS25855	COG1280	lysine exporter protein (LysE YggA)
IS497_RS25865	COG1280	lysine exporter protein (LysE YggA)
IS497_RS25895	COG0210	DNA helicase
IS497_RS25900	COG1011	Hydrolase
IS497_RS25930	COG3072	Adenylate cyclase
IS497_RS25945	COG2959	enzyme of heme biosynthesis
IS497_RS25950	COG3071	HemY protein
IS497_RS25995	COG2244	polysaccharide biosynthetic process
IS497_RS26000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IS497_RS26005	COG0456	acetyltransferase
IS497_RS26010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IS497_RS26015	COG1088	dTDP-glucose 4,6-dehydratase activity
IS497_RS26020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IS497_RS26025	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IS497_RS26035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS497_RS26040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IS497_RS26045	COG3118	belongs to the thioredoxin family
IS497_RS26070	COG1811	Na channel or pump
IS497_RS26080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS497_RS26085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS497_RS26095	COG0583	DNA-binding transcription factor activity
IS497_RS26100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS497_RS26115	COG3978	acetolactate synthase activity
IS497_RS26135	COG3085	chromosome segregation
IS497_RS26210	COG0583	DNA-binding transcription factor activity
IS497_RS26225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IS497_RS26240	COG3443	Belongs to the bacterial solute-binding protein 9 family
IS497_RS26245	COG2207	Transcriptional regulator
IS497_RS26255	COG0371	Dehydrogenase
IS497_RS26260	COG0697	spore germination
IS497_RS26270	COG0583	DNA-binding transcription factor activity
IS497_RS26280	COG0737	Belongs to the 5'-nucleotidase family
IS497_RS26290	COG0527	aspartate kinase activity
IS497_RS26290	COG0460	homoserine dehydrogenase
IS497_RS26295	COG0626	cystathionine gamma-synthase activity
IS497_RS26310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IS497_RS26315	COG1609	Transcriptional regulator
IS497_RS26320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS497_RS26335	COG1575	Belongs to the MenA family. Type 1 subfamily
IS497_RS26355	COG3678	ATP-independent chaperone mediated protein folding
IS497_RS26360	COG0745	RESPONSE REGULATOR receiver
IS497_RS26365	COG2205	protein histidine kinase activity
IS497_RS26370	COG2258	MOSC domain
IS497_RS26375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IS497_RS26415	COG1129	ABC transporter
IS497_RS26420	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS26425	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS26430	COG1454	alcohol dehydrogenase
IS497_RS26440	COG2211	Major facilitator Superfamily
IS497_RS26500	COG0205	6-phosphofructokinase activity
IS497_RS26520	COG0437	4 iron, 4 sulfur cluster binding
IS497_RS26525	COG2864	formate dehydrogenase
IS497_RS26540	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IS497_RS26545	COG0657	acetylesterase activity
IS497_RS26550	COG0456	acetyltransferase
IS497_RS26565	COG1011	Hydrolase
IS497_RS26580	COG3852	Histidine kinase
IS497_RS26595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS497_RS26615	COG0204	Acyl-transferase
IS497_RS26625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IS497_RS26630	COG3084	Protein conserved in bacteria
IS497_RS26640	COG1763	Mo-molybdopterin cofactor biosynthetic process
IS497_RS26665	COG2186	Transcriptional regulator
IS497_RS26670	COG0477	Major facilitator Superfamily
IS497_RS26675	COG1609	Transcriptional regulator
IS497_RS26680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS497_RS26690	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS497_RS26695	COG1129	ABC transporter
IS497_RS26725	COG1522	sequence-specific DNA binding
IS497_RS26730	COG0716	FMN binding
IS497_RS26745	COG3312	ion transport
IS497_RS26795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS497_RS26800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS497_RS26805	COG0573	inorganic phosphate transmembrane transporter activity
IS497_RS26810	COG0581	inorganic phosphate transmembrane transporter activity
IS497_RS26815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS497_RS26820	COG0704	Plays a role in the regulation of phosphate uptake
IS497_RS26830	COG2382	esterase
IS497_RS26835	COG0363	glucosamine-6-phosphate deaminase activity
IS497_RS26840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS497_RS26845	COG2252	PERMEase
IS497_RS26850	COG0431	NADPH-dependent FMN reductase
IS497_RS26855	COG2091	lysine biosynthetic process via aminoadipic acid
IS497_RS26885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IS497_RS27005	COG1702	phosphate starvation-inducible protein PhoH
IS497_RS27010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS497_RS27080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IS497_RS27150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS497_RS27155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS497_RS27165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IS497_RS27215	COG4735	regulation of single-species biofilm formation
IS497_RS27260	COG3039	Transposase
IS497_RS27350	COG1475	DNA binding
IS497_RS27355	COG1475	DNA binding
IS497_RS27360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS497_RS27450	COG3941	tape measure
IS497_RS27550	COG0500	methyltransferase
IS497_RS27585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IS497_RS27595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS497_RS27615	COG0523	cobalamin synthesis protein
IS497_RS27785	COG1522	sequence-specific DNA binding
IS497_RS27800	COG0604	alcohol dehydrogenase
IS497_RS27800	COG3321	synthase
IS497_RS27800	COG1028	Short-chain dehydrogenase reductase Sdr
IS497_RS27890	COG1358	cellular component organization or biogenesis
IS497_RS27910	COG4245	von Willebrand factor, type A
IS497_RS27920	COG4245	von Willebrand factor, type A
IS497_RS27925	COG4245	von Willebrand factor, type A
IS497_RS27945	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
IS497_RS27980	COG2144	transferase activity, transferring acyl groups
IS497_RS28005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS497_RS28045	COG3344	reverse transcriptase
IS497_RS28100	COG4372	Transposase
IS497_RS28105	COG3436	PFAM IS66 Orf2 family protein
IS497_RS28275	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS497_RS28305	COG0739	heme binding
IS497_RS28315	COG2132	Multicopper oxidase
IS497_RS28335	COG2372	response to copper ion
IS497_RS28340	COG1276	copper resistance
IS497_RS28345	COG0745	RESPONSE REGULATOR receiver
IS497_RS28350	COG2205	protein histidine kinase activity
IS497_RS28365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IS497_RS28380	COG0789	Transcriptional regulator
IS497_RS28435	COG5499	transcription regulator containing HTH domain
IS497_RS28440	COG4680	protein conserved in bacteria
IS497_RS28505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IS497_RS28550	COG0523	cobalamin synthesis protein
IS497_RS28575	COG0523	cobalamin synthesis protein
IS497_RS28580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IS497_RS28585	COG0735	belongs to the Fur family
IS497_RS28630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS497_RS28655	COG0656	L-ascorbic acid biosynthetic process
IS497_RS28665	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS497_RS28690	COG5654	RES domain protein
IS497_RS28695	COG5642	Protein of unknown function (DUF2384)
IS497_RS28800	COG3344	reverse transcriptase
IS497_RS29015	COG3300	MHYT domain
IS497_RS29015	COG5001	Diguanylate cyclase
IS497_RS29165	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IS497_RS29410	COG3436	PFAM IS66 Orf2 family protein
IS497_RS29415	COG4372	Transposase
IS497_RS29490	COG4372	Transposase
IS497_RS29495	COG3436	PFAM IS66 Orf2 family protein
IS497_RS29530	COG3344	reverse transcriptase
IS497_RS29610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IS497_RS29680	COG0768	penicillin binding
IS497_RS29790	COG2003	Belongs to the UPF0758 family
IS497_RS29870	COG2198	Histidine kinase
IS497_RS29870	COG5002	protein histidine kinase activity
IS497_RS29870	COG0784	Response regulator, receiver
IS497_RS29895	COG0741	lytic transglycosylase activity
IS497_RS30005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS497_RS30025	COG3344	reverse transcriptase