locus-tag	class	description
IS502_RS00020	COG0187	DNA topoisomerase II activity
IS502_RS00025	COG0561	phosphatase activity
IS502_RS00040	COG2186	Transcriptional regulator
IS502_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
IS502_RS00050	COG0800	Aldolase
IS502_RS00070	COG2271	Major facilitator Superfamily
IS502_RS00075	COG0823	Involved in the tonB-independent uptake of proteins
IS502_RS00080	COG5645	(Lipo)protein
IS502_RS00095	COG3645	SOS response
IS502_RS00105	COG2188	Transcriptional regulator
IS502_RS00120	COG2149	membrane
IS502_RS00140	COG2610	gluconate transmembrane transporter activity
IS502_RS00150	COG0583	DNA-binding transcription factor activity
IS502_RS00155	COG2814	Major facilitator Superfamily
IS502_RS00185	COG0028	Belongs to the TPP enzyme family
IS502_RS00190	COG0440	acetolactate synthase activity
IS502_RS00195	COG2197	response regulator
IS502_RS00205	COG2271	Major facilitator Superfamily
IS502_RS00245	COG2188	Transcriptional regulator
IS502_RS00270	COG4580	involved in the transport of maltose and maltodextrins
IS502_RS00275	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS502_RS00280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS00280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS00290	COG1609	Transcriptional regulator
IS502_RS00300	COG3384	dioxygenase
IS502_RS00305	COG0583	DNA-binding transcription factor activity
IS502_RS00310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IS502_RS00315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS502_RS00320	COG2828	Protein conserved in bacteria
IS502_RS00335	COG0697	spore germination
IS502_RS00340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS00340	COG1263	PTS System
IS502_RS00350	COG2814	Major facilitator Superfamily
IS502_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS502_RS00395	COG0583	DNA-binding transcription factor activity
IS502_RS00420	COG1464	Belongs to the NlpA lipoprotein family
IS502_RS00435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IS502_RS00445	COG1064	alcohol dehydrogenase
IS502_RS00475	COG2211	Major facilitator Superfamily
IS502_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
IS502_RS00490	COG1486	melibiose metabolic process
IS502_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS00495	COG1263	PTS System
IS502_RS00500	COG2982	Protein involved in outer membrane biogenesis
IS502_RS00505	COG2233	PERMEase
IS502_RS00510	COG0786	glutamate:sodium symporter activity
IS502_RS00530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IS502_RS00555	COG3152	Membrane
IS502_RS00565	COG1494	fructose-1,6-bisphosphatase
IS502_RS00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IS502_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS502_RS00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS502_RS00600	COG2860	membrane
IS502_RS00610	COG2169	Transcriptional regulator
IS502_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS502_RS00615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IS502_RS00620	COG1561	YicC-like family, N-terminal region
IS502_RS00625	COG3039	Transposase
IS502_RS00645	COG1131	(ABC) transporter
IS502_RS00650	COG0842	Transport permease protein
IS502_RS00675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IS502_RS00710	COG1519	Transferase
IS502_RS00715	COG1216	Glycosyl transferase, family 2
IS502_RS00720	COG0438	transferase activity, transferring glycosyl groups
IS502_RS00730	COG0859	PFAM glycosyl transferase family 9
IS502_RS00755	COG0859	PFAM glycosyl transferase family 9
IS502_RS00770	COG0156	8-amino-7-oxononanoate synthase activity
IS502_RS00780	COG0463	Glycosyl transferase, family 2
IS502_RS00785	COG2861	carbohydrate metabolic process
IS502_RS00790	COG4942	peptidase
IS502_RS00800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS502_RS00805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS502_RS00825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IS502_RS00835	COG2186	Transcriptional regulator
IS502_RS00855	COG3722	fumarate hydratase activity
IS502_RS00875	COG1566	PFAM secretion protein HlyD family protein
IS502_RS00880	COG0625	glutathione transferase activity
IS502_RS00890	COG3276	selenocysteine insertion sequence binding
IS502_RS00895	COG1414	Transcriptional regulator
IS502_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS502_RS00905	COG3977	Valine--pyruvate aminotransferase
IS502_RS00910	COG0366	Alpha amylase catalytic
IS502_RS00915	COG2992	FlgJ-related protein
IS502_RS00920	COG1609	Transcriptional regulator
IS502_RS00920	COG2207	Transcriptional regulator
IS502_RS00925	COG4214	carbohydrate transport
IS502_RS00935	COG4213	ABC transporter substrate-binding protein
IS502_RS00950	COG4682	membrane
IS502_RS00955	COG4682	membrane
IS502_RS00960	COG3274	enterobacterial common antigen metabolic process
IS502_RS00985	COG3039	Transposase
IS502_RS01000	COG1278	Cold shock
IS502_RS01005	COG2944	sequence-specific DNA binding
IS502_RS01010	COG2814	Major facilitator Superfamily
IS502_RS01030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS01040	COG1609	Transcriptional regulator
IS502_RS01045	COG2885	chlorophyll binding
IS502_RS01050	COG0243	molybdopterin cofactor binding
IS502_RS01055	COG0456	acetyltransferase
IS502_RS01060	COG2818	Glycosylase
IS502_RS01065	COG5571	outer membrane autotransporter
IS502_RS01070	COG2223	nitrite transmembrane transporter activity
IS502_RS01100	COG0747	negative chemotaxis
IS502_RS01105	COG0601	transmembrane transport
IS502_RS01110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS502_RS01115	COG0444	Belongs to the ABC transporter superfamily
IS502_RS01120	COG4608	Belongs to the ABC transporter superfamily
IS502_RS01145	COG1215	transferase activity, transferring glycosyl groups
IS502_RS01150	COG0457	Tetratricopeptide repeat
IS502_RS01165	COG2194	sulfuric ester hydrolase activity
IS502_RS01195	COG1215	transferase activity, transferring glycosyl groups
IS502_RS01200	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IS502_RS01205	COG0457	Tetratricopeptide repeat
IS502_RS01205	COG3118	belongs to the thioredoxin family
IS502_RS01210	COG2199	diguanylate cyclase activity
IS502_RS01210	COG2200	EAL domain
IS502_RS01220	COG0612	Peptidase, M16
IS502_RS01230	COG2982	Protein involved in outer membrane biogenesis
IS502_RS01235	COG0477	Major facilitator Superfamily
IS502_RS01240	COG1295	ribonuclease BN
IS502_RS01245	COG0583	DNA-binding transcription factor activity
IS502_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS502_RS01265	COG1454	alcohol dehydrogenase
IS502_RS01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS502_RS01280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IS502_RS01285	COG0671	phosphoesterase, PA-phosphatase related
IS502_RS01305	COG0589	response to stress
IS502_RS01315	COG0306	phosphate transporter
IS502_RS01320	COG2081	HI0933 family
IS502_RS01325	COG2239	Acts as a magnesium transporter
IS502_RS01335	COG1124	(ABC) transporter
IS502_RS01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS502_RS01350	COG0601	transmembrane transport
IS502_RS01355	COG0747	negative chemotaxis
IS502_RS01365	COG3479	Phenolic acid decarboxylase
IS502_RS01405	COG0628	permease
IS502_RS01410	COG0477	Major facilitator Superfamily
IS502_RS01420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS502_RS01435	COG3714	YhhN family
IS502_RS01445	COG3776	membrane
IS502_RS01450	COG0742	ribosomal rna small subunit methyltransferase
IS502_RS01455	COG0552	protein localization to endoplasmic reticulum
IS502_RS01460	COG2884	Cell division ATP-binding protein ftsE
IS502_RS01465	COG2177	Part of the ABC transporter FtsEX involved in
IS502_RS01480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS502_RS01490	COG0683	leucine binding
IS502_RS01500	COG0683	leucine binding
IS502_RS01505	COG0559	Belongs to the binding-protein-dependent transport system permease family
IS502_RS01555	COG0584	glycerophosphoryl diester phosphodiesterase
IS502_RS01565	COG0405	Gamma-glutamyltransferase
IS502_RS01570	COG1247	-acetyltransferase
IS502_RS01580	COG0673	inositol 2-dehydrogenase activity
IS502_RS01585	COG1741	Belongs to the pirin family
IS502_RS01590	COG1609	Transcriptional regulator
IS502_RS01595	COG3265	gluconokinase activity
IS502_RS01600	COG2610	gluconate transmembrane transporter activity
IS502_RS01610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS502_RS01635	COG0058	SHG alpha-glucan phosphorylase activity
IS502_RS01650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS502_RS01665	COG1349	DNA-binding transcription factor activity
IS502_RS01690	COG0058	SHG alpha-glucan phosphorylase activity
IS502_RS01695	COG1640	4-alpha-glucanotransferase
IS502_RS01700	COG2610	gluconate transmembrane transporter activity
IS502_RS01710	COG1040	competence protein
IS502_RS01735	COG1918	ferrous iron import across plasma membrane
IS502_RS01740	COG2183	response to ionizing radiation
IS502_RS01745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS502_RS01770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IS502_RS01775	COG1011	Hydrolase
IS502_RS01785	COG0494	nUDIX hydrolase
IS502_RS01790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IS502_RS01815	COG4796	Type ii and iii secretion system protein
IS502_RS01830	COG3266	domain, Protein
IS502_RS01835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IS502_RS01840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS502_RS01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS502_RS01870	COG0402	S-adenosylhomocysteine deaminase activity
IS502_RS01875	COG0738	Major facilitator superfamily
IS502_RS01900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS502_RS01905	COG1289	transmembrane transporter activity
IS502_RS01915	COG1765	OsmC-like protein
IS502_RS01920	COG3954	Phosphoribulokinase
IS502_RS01930	COG0429	hydrolase of the alpha beta-hydrolase fold
IS502_RS01935	COG0488	(ABC) transporter
IS502_RS01950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IS502_RS01955	COG1047	Peptidyl-prolyl cis-trans
IS502_RS01965	COG0545	Peptidyl-prolyl cis-trans isomerase
IS502_RS01970	COG2964	Protein conserved in bacteria
IS502_RS02025	COG0051	transcription antitermination factor activity, RNA binding
IS502_RS02050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IS502_RS02065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IS502_RS02130	COG0201	protein transport
IS502_RS02155	COG0202	RNA polymerase activity
IS502_RS02170	COG0789	Transcriptional regulator
IS502_RS02175	COG3036	rescue of stalled ribosome
IS502_RS02205	COG0758	DNA mediated transformation
IS502_RS02215	COG0551	DNA topoisomerase type I activity
IS502_RS02235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS502_RS02270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS502_RS02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS02280	COG1309	transcriptional regulator
IS502_RS02285	COG0582	viral genome integration into host DNA
IS502_RS02300	COG3561	AntA/AntB antirepressor
IS502_RS02385	COG4626	Terminase
IS502_RS02385	COG1802	Transcriptional regulator
IS502_RS02410	COG4145	pantothenate transmembrane transporter activity
IS502_RS02415	COG3924	membrane
IS502_RS02420	COG0439	Biotin carboxylase
IS502_RS02425	COG0511	ligase activity, forming carbon-carbon bonds
IS502_RS02450	COG2199	diguanylate cyclase activity
IS502_RS02450	COG2200	EAL domain
IS502_RS02455	COG1077	Cell shape determining protein MreB Mrl
IS502_RS02460	COG1792	Involved in formation and maintenance of cell shape
IS502_RS02465	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IS502_RS02475	COG1530	ribonuclease E activity
IS502_RS02480	COG3164	Protein of unknown function
IS502_RS02485	COG0312	modulator of DNA gyrase
IS502_RS02490	COG0583	DNA-binding transcription factor activity
IS502_RS02505	COG1289	transmembrane transporter activity
IS502_RS02510	COG2732	(Barnase) inhibitor
IS502_RS02535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS502_RS02540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS502_RS02545	COG3105	Protein conserved in bacteria
IS502_RS02550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS502_RS02570	COG0625	glutathione transferase activity
IS502_RS02575	COG2969	positive regulation of protein catabolic process
IS502_RS02585	COG0493	'glutamate synthase
IS502_RS02590	COG0067	glutamate synthase
IS502_RS02590	COG0069	glutamate synthase activity
IS502_RS02590	COG0070	glutamate synthase
IS502_RS02595	COG1242	4 iron, 4 sulfur cluster binding
IS502_RS02600	COG2271	Major facilitator Superfamily
IS502_RS02605	COG1063	alcohol dehydrogenase
IS502_RS02610	COG1312	Catalyzes the dehydration of D-mannonate
IS502_RS02615	COG5002	protein histidine kinase activity
IS502_RS02615	COG0784	Response regulator, receiver
IS502_RS02615	COG2198	Histidine kinase
IS502_RS02620	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IS502_RS02625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS502_RS02630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS02640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS02645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS502_RS02650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IS502_RS02655	COG1137	ATPase activity
IS502_RS02660	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IS502_RS02665	COG3117	lipopolysaccharide transmembrane transporter activity
IS502_RS02670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IS502_RS02680	COG0530	calcium, potassium:sodium antiporter activity
IS502_RS02685	COG1127	ABC transporter
IS502_RS02690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS502_RS02695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS502_RS02700	COG2854	intermembrane phospholipid transfer
IS502_RS02705	COG3113	response to antibiotic
IS502_RS02710	COG5007	Belongs to the BolA IbaG family
IS502_RS02720	COG3423	Transcriptional regulator
IS502_RS02725	COG0142	geranyltranstransferase activity
IS502_RS02740	COG0697	spore germination
IS502_RS02750	COG2027	D-alanyl-D-alanine carboxypeptidase
IS502_RS02760	COG1534	Rna-binding protein
IS502_RS02770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IS502_RS02775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IS502_RS02785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IS502_RS02825	COG0195	Participates in both transcription termination and antitermination
IS502_RS02870	COG0814	amino acid
IS502_RS02875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS502_RS02880	COG0826	peptidase U32
IS502_RS02885	COG0826	peptidase U32
IS502_RS02890	COG3154	lipid carrier protein
IS502_RS02895	COG3153	acetyltransferase
IS502_RS02910	COG0693	protein deglycase activity
IS502_RS02915	COG0702	epimerase
IS502_RS02920	COG0701	Predicted permease
IS502_RS02925	COG2823	Periplasmic or secreted lipoprotein
IS502_RS02945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IS502_RS02960	COG1063	alcohol dehydrogenase
IS502_RS02965	COG3775	system Galactitol-specific IIC component
IS502_RS02970	COG3414	Phosphotransferase system galactitol-specific IIB component
IS502_RS02975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS02985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS02985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS02990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS502_RS02990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS02990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS502_RS02995	COG1105	Belongs to the carbohydrate kinase PfkB family
IS502_RS03005	COG1349	DNA-binding transcription factor activity
IS502_RS03010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS03015	COG2721	sulfolactate sulfo-lyase activity
IS502_RS03020	COG2271	Major facilitator Superfamily
IS502_RS03030	COG2084	Dehydrogenase
IS502_RS03035	COG1929	Belongs to the glycerate kinase type-1 family
IS502_RS03060	COG1741	Belongs to the pirin family
IS502_RS03065	COG0583	DNA-binding transcription factor activity
IS502_RS03070	COG3152	Membrane
IS502_RS03075	COG0435	Glutathione S-transferase
IS502_RS03080	COG2259	Doxx family
IS502_RS03090	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IS502_RS03095	COG4575	ribosome binding
IS502_RS03100	COG1422	Protein of unknown function (DUF1090)
IS502_RS03110	COG0586	Pfam SNARE associated Golgi protein
IS502_RS03115	COG2186	Transcriptional regulator
IS502_RS03120	COG2271	Major facilitator Superfamily
IS502_RS03130	COG2721	sulfolactate sulfo-lyase activity
IS502_RS03145	COG0861	Integral membrane protein TerC family
IS502_RS03150	COG0673	inositol 2-dehydrogenase activity
IS502_RS03155	COG1451	nucleotide metabolic process
IS502_RS03175	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS502_RS03175	COG1902	pentaerythritol trinitrate reductase activity
IS502_RS03225	COG1695	Transcriptional regulator
IS502_RS03230	COG2375	cellular response to nickel ion
IS502_RS03245	COG1461	Dihydroxyacetone kinase
IS502_RS03250	COG2376	Dihydroxyacetone kinase
IS502_RS03320	COG3247	response to pH
IS502_RS03330	COG2205	protein histidine kinase activity
IS502_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS03330	COG0784	Response regulator, receiver
IS502_RS03330	COG2198	Histidine kinase
IS502_RS03335	COG2197	response regulator
IS502_RS03360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS502_RS03365	COG0358	DNA primase activity
IS502_RS03370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IS502_RS03440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS502_RS03455	COG4991	sh3 domain protein
IS502_RS03460	COG3025	triphosphatase activity
IS502_RS03485	COG2960	long-chain fatty acid transporting porin activity
IS502_RS03500	COG3384	dioxygenase
IS502_RS03505	COG0754	glutathionylspermidine amidase activity
IS502_RS03520	COG0494	nUDIX hydrolase
IS502_RS03525	COG3151	Protein conserved in bacteria
IS502_RS03530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS502_RS03535	COG3150	esterase
IS502_RS03545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IS502_RS03550	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS502_RS03555	COG0642	Histidine kinase
IS502_RS03565	COG3111	PFAM Bacterial OB fold (BOF) protein
IS502_RS03570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IS502_RS03575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IS502_RS03580	COG0204	Acyl-transferase
IS502_RS03585	COG2132	Multicopper oxidase
IS502_RS03590	COG1032	radical SAM domain protein
IS502_RS03600	COG0656	L-ascorbic acid biosynthetic process
IS502_RS03605	COG1979	alcohol dehydrogenase
IS502_RS03610	COG2207	Transcriptional regulator
IS502_RS03615	COG0586	Pfam SNARE associated Golgi protein
IS502_RS03620	COG0626	cystathionine gamma-synthase activity
IS502_RS03630	COG0848	biopolymer transport protein
IS502_RS03635	COG2211	Major facilitator Superfamily
IS502_RS03660	COG0625	glutathione transferase activity
IS502_RS03675	COG0754	glutathionylspermidine amidase activity
IS502_RS03680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS502_RS03700	COG0583	DNA-binding transcription factor activity
IS502_RS03705	COG0626	cystathionine gamma-synthase activity
IS502_RS03915	COG3039	Transposase
IS502_RS03965	COG3423	Transcriptional regulator
IS502_RS03975	COG1278	Cold shock
IS502_RS03980	COG3423	Transcriptional regulator
IS502_RS04045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS502_RS04055	COG1811	Na channel or pump
IS502_RS04060	COG1982	Orn Lys Arg decarboxylase major
IS502_RS04065	COG2211	Major facilitator Superfamily
IS502_RS04080	COG1194	a g-specific adenine glycosylase
IS502_RS04090	COG3171	Protein conserved in bacteria
IS502_RS04100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS502_RS04115	COG0762	integral membrane protein
IS502_RS04120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IS502_RS04125	COG2805	Type II/IV secretion system protein
IS502_RS04145	COG0189	ligase activity
IS502_RS04150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IS502_RS04155	COG2356	endonuclease I
IS502_RS04165	COG2814	Major facilitator Superfamily
IS502_RS04200	COG2146	nitrite reductase [NAD(P)H] activity
IS502_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS04220	COG1414	Transcriptional regulator
IS502_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS04255	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IS502_RS04285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS502_RS04300	COG0191	fructose-bisphosphate aldolase activity
IS502_RS04305	COG0668	transmembrane transport
IS502_RS04315	COG2968	Membrane
IS502_RS04330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS502_RS04335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IS502_RS04355	COG0006	proline dipeptidase activity
IS502_RS04360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS502_RS04365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS502_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS04390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS502_RS04410	COG2723	6-phospho-beta-galactosidase activity
IS502_RS04415	COG1737	Transcriptional regulator
IS502_RS04425	COG1272	protein, Hemolysin III
IS502_RS04435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IS502_RS04445	COG0716	FMN binding
IS502_RS04450	COG4974	Belongs to the 'phage' integrase family
IS502_RS04460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IS502_RS04480	COG4942	peptidase
IS502_RS04490	COG2814	Major facilitator Superfamily
IS502_RS04505	COG0667	Aldo Keto reductase
IS502_RS04540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS502_RS04545	COG1393	Belongs to the ArsC family
IS502_RS04560	COG1538	Outer membrane efflux protein
IS502_RS04565	COG1289	transmembrane transporter activity
IS502_RS04580	COG3592	Divergent 4Fe-4S mono-cluster
IS502_RS04585	COG2388	GCN5-related N-acetyl-transferase
IS502_RS04595	COG3539	Fimbrial protein
IS502_RS04600	COG3539	Fimbrial protein
IS502_RS04605	COG3539	Fimbrial protein
IS502_RS04610	COG3188	usher protein
IS502_RS04615	COG3121	Chaperone
IS502_RS04620	COG3539	Fimbrial protein
IS502_RS04630	COG4974	Belongs to the 'phage' integrase family
IS502_RS04635	COG0582	viral genome integration into host DNA
IS502_RS04640	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS502_RS04645	COG1846	Transcriptional regulator
IS502_RS04650	COG0697	spore germination
IS502_RS04705	COG3436	PFAM IS66 Orf2 family protein
IS502_RS04710	COG4372	Transposase
IS502_RS04715	COG0667	Aldo Keto reductase
IS502_RS04720	COG0814	amino acid
IS502_RS04735	COG0183	Belongs to the thiolase family
IS502_RS04745	COG0823	Involved in the tonB-independent uptake of proteins
IS502_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS04755	COG2814	Major facilitator Superfamily
IS502_RS04790	COG3842	ATPase activity
IS502_RS04795	COG0395	ABC-type sugar transport system, permease component
IS502_RS04800	COG1175	transmembrane transport
IS502_RS04805	COG1917	Cupin 2, conserved barrel domain protein
IS502_RS04810	COG1794	racemase activity, acting on amino acids and derivatives
IS502_RS04815	COG0583	DNA-binding transcription factor activity
IS502_RS04825	COG1609	Transcriptional regulator
IS502_RS04830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS04835	COG2723	6-phospho-beta-galactosidase activity
IS502_RS04840	COG2186	Transcriptional regulator
IS502_RS04850	COG1609	Transcriptional regulator
IS502_RS04870	COG0667	Aldo Keto reductase
IS502_RS04880	COG0861	Integral membrane protein TerC family
IS502_RS04915	COG2165	general secretion pathway protein
IS502_RS04920	COG4795	General secretion pathway protein
IS502_RS04930	COG4967	type IV pilus modification protein PilV
IS502_RS04935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IS502_RS04940	COG1025	Belongs to the peptidase M16 family
IS502_RS04945	COG1074	ATP-dependent DNA helicase activity
IS502_RS04950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IS502_RS04960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IS502_RS04960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IS502_RS04965	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS502_RS04970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS502_RS05000	COG4656	Part of a membrane complex involved in electron transport
IS502_RS05005	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS05005	COG1454	alcohol dehydrogenase
IS502_RS05035	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IS502_RS05200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IS502_RS05205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IS502_RS05210	COG2166	iron-sulfur cluster assembly
IS502_RS05215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS502_RS05225	COG0583	DNA-binding transcription factor activity
IS502_RS05230	COG2363	Small membrane protein
IS502_RS05240	COG1349	DNA-binding transcription factor activity
IS502_RS05260	COG0738	Major facilitator superfamily
IS502_RS05265	COG0235	Class ii aldolase
IS502_RS05270	COG1454	alcohol dehydrogenase
IS502_RS05290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS502_RS05305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS502_RS05310	COG2011	ABC-type metal ion transport system permease component
IS502_RS05315	COG1464	Belongs to the NlpA lipoprotein family
IS502_RS05320	COG0477	Major facilitator Superfamily
IS502_RS05330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS502_RS05335	COG1760	l-serine dehydratase
IS502_RS05340	COG0814	amino acid
IS502_RS05345	COG1611	Belongs to the LOG family
IS502_RS05360	COG3098	single-species biofilm formation
IS502_RS05365	COG0564	pseudouridine synthase activity
IS502_RS05370	COG0716	FMN binding
IS502_RS05375	COG2271	Major facilitator Superfamily
IS502_RS05380	COG4948	Mandelate Racemase Muconate Lactonizing
IS502_RS05385	COG4948	Mandelate Racemase Muconate Lactonizing
IS502_RS05390	COG1929	Belongs to the glycerate kinase type-1 family
IS502_RS05395	COG4999	Histidine kinase
IS502_RS05395	COG3850	Histidine kinase
IS502_RS05395	COG3437	response regulator, receiver
IS502_RS05395	COG2205	protein histidine kinase activity
IS502_RS05405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS502_RS05410	COG3956	TIGRFAM MazG family protein
IS502_RS05430	COG0602	queuosine metabolic process
IS502_RS05435	COG0720	synthase
IS502_RS05455	COG2234	aminopeptidase activity
IS502_RS05515	COG1388	LysM domain
IS502_RS05515	COG4942	peptidase
IS502_RS05520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS502_RS05545	COG0163	prenyltransferase activity
IS502_RS05550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS502_RS05590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS05595	COG4558	Periplasmic binding protein
IS502_RS05600	COG3720	iron ion transport
IS502_RS05620	COG0679	Auxin Efflux Carrier
IS502_RS05635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS502_RS05640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS502_RS05645	COG1121	(ABC) transporter
IS502_RS05650	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS502_RS05655	COG1609	Transcriptional regulator
IS502_RS05660	COG1940	carbohydrate kinase activity
IS502_RS05665	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS502_RS05670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS05675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS05680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS05685	COG4580	involved in the transport of maltose and maltodextrins
IS502_RS05695	COG2723	6-phospho-beta-galactosidase activity
IS502_RS05705	COG0309	Hydrogenase expression formation protein (HypE)
IS502_RS05710	COG0409	Hydrogenase expression formation protein
IS502_RS05715	COG0298	carbon dioxide binding
IS502_RS05720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IS502_RS05735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS502_RS05740	COG0651	ATP synthesis coupled electron transport
IS502_RS05745	COG0650	Formate hydrogenlyase subunit 4
IS502_RS05750	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IS502_RS05750	COG3261	NADH dehydrogenase
IS502_RS05755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS502_RS05760	COG3260	NADH ubiquinone oxidoreductase 20
IS502_RS05770	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IS502_RS05780	COG2723	6-phospho-beta-galactosidase activity
IS502_RS05785	COG1263	PTS System
IS502_RS05785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS05790	COG1609	Transcriptional regulator
IS502_RS05795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS502_RS05800	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IS502_RS05805	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IS502_RS05830	COG1349	DNA-binding transcription factor activity
IS502_RS05835	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS05850	COG3732	PTS system glucitol sorbitol-specific
IS502_RS05855	COG3730	PTS system glucitol sorbitol-specific
IS502_RS05860	COG2951	lytic endotransglycosylase activity
IS502_RS05865	COG1121	(ABC) transporter
IS502_RS05870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS502_RS05875	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS502_RS05880	COG1546	Belongs to the CinA family
IS502_RS05900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IS502_RS05930	COG2823	Periplasmic or secreted lipoprotein
IS502_RS05935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS502_RS05940	COG1238	metal cluster binding
IS502_RS05960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IS502_RS05965	COG2814	Major facilitator Superfamily
IS502_RS05970	COG1566	PFAM secretion protein HlyD family protein
IS502_RS05975	COG1846	Transcriptional regulator
IS502_RS05985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IS502_RS05995	COG4176	ABC-type proline glycine betaine transport system permease component
IS502_RS06010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS502_RS06020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS502_RS06025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS502_RS06030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS502_RS06035	COG4575	ribosome binding
IS502_RS06050	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS502_RS06065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS502_RS06070	COG0640	Transcriptional regulator
IS502_RS06080	COG0583	DNA-binding transcription factor activity
IS502_RS06085	COG3284	Transcriptional regulator
IS502_RS06100	COG4974	Belongs to the 'phage' integrase family
IS502_RS06135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS502_RS06150	COG3344	reverse transcriptase
IS502_RS06185	COG4695	Portal protein
IS502_RS06350	COG2867	negative regulation of translational initiation
IS502_RS06365	COG0497	DNA recombination
IS502_RS06380	COG4536	flavin adenine dinucleotide binding
IS502_RS06385	COG4137	Cytochrome C assembly protein
IS502_RS06390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IS502_RS06425	COG2885	chlorophyll binding
IS502_RS06430	COG2199	diguanylate cyclase activity
IS502_RS06440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS502_RS06445	COG0287	Prephenate dehydrogenase
IS502_RS06445	COG1605	Chorismate mutase
IS502_RS06455	COG0077	Prephenate dehydratase
IS502_RS06455	COG1605	Chorismate mutase
IS502_RS06465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS502_RS06470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS502_RS06485	COG0542	response to heat
IS502_RS06510	COG0477	Major facilitator Superfamily
IS502_RS06515	COG5544	Lipoprotein
IS502_RS06520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS502_RS06530	COG3148	PFAM DTW domain containing protein
IS502_RS06535	COG3118	belongs to the thioredoxin family
IS502_RS06540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS502_RS06555	COG0513	Belongs to the DEAD box helicase family
IS502_RS06565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IS502_RS06580	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IS502_RS06585	COG3026	antisigma factor binding
IS502_RS06590	COG3086	response to oxidative stress
IS502_RS06600	COG0681	Belongs to the peptidase S26 family
IS502_RS06620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS502_RS06630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS502_RS06635	COG1737	Transcriptional regulator
IS502_RS06640	COG0560	Phosphoserine phosphatase
IS502_RS06655	COG0047	phosphoribosylformylglycinamidine synthase activity
IS502_RS06655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IS502_RS06660	COG2205	protein histidine kinase activity
IS502_RS06665	COG3170	Tfp pilus assembly protein FimV
IS502_RS06670	COG2204	response regulator
IS502_RS06675	COG0347	Belongs to the P(II) protein family
IS502_RS06680	COG1017	nitric oxide dioxygenase activity
IS502_RS06680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS502_RS06690	COG2259	Doxx family
IS502_RS06695	COG1940	carbohydrate kinase activity
IS502_RS06700	COG0457	Tetratricopeptide repeat
IS502_RS06705	COG0477	Major facilitator Superfamily
IS502_RS06705	COG2814	Major facilitator Superfamily
IS502_RS06710	COG2017	converts alpha-aldose to the beta-anomer
IS502_RS06715	COG2814	Major facilitator Superfamily
IS502_RS06720	COG3711	transcriptional antiterminator
IS502_RS06725	COG3683	transport system, periplasmic component
IS502_RS06730	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS502_RS06765	COG0822	iron-sulfur transferase activity
IS502_RS06785	COG0633	Ferredoxin
IS502_RS06790	COG2975	iron-sulfur cluster assembly
IS502_RS06810	COG2897	thiosulfate sulfurtransferase activity
IS502_RS06815	COG2373	Large extracellular alpha-helical protein
IS502_RS06820	COG4953	penicillin-binding protein 1C
IS502_RS06850	COG2976	Protein conserved in bacteria
IS502_RS06870	COG1645	bacterial-type flagellum-dependent swarming motility
IS502_RS06880	COG0517	IMP dehydrogenase activity
IS502_RS06880	COG0516	GMP reductase activity
IS502_RS06925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS502_RS07010	COG3728	DNA packaging
IS502_RS07010	COG5484	DNA packaging
IS502_RS07100	COG3617	BRO family, N-terminal domain
IS502_RS07130	COG3179	chitinase
IS502_RS07140	COG3119	arylsulfatase activity
IS502_RS07145	COG0641	radical SAM
IS502_RS07165	COG2200	EAL domain
IS502_RS07180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IS502_RS07195	COG2723	6-phospho-beta-galactosidase activity
IS502_RS07205	COG2233	PERMEase
IS502_RS07220	COG1393	Belongs to the ArsC family
IS502_RS07225	COG4783	chaperone-mediated protein folding
IS502_RS07235	COG0628	permease
IS502_RS07240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IS502_RS07245	COG2716	regulation of RNA biosynthetic process
IS502_RS07255	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IS502_RS07265	COG2321	neutral zinc metallopeptidase
IS502_RS07270	COG1444	tRNA N-acetyltransferase activity
IS502_RS07275	COG0400	carboxylic ester hydrolase activity
IS502_RS07290	COG1393	Belongs to the ArsC family
IS502_RS07300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS502_RS07305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS502_RS07305	COG0493	'glutamate synthase
IS502_RS07315	COG5342	invasion associated locus B
IS502_RS07320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS502_RS07325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS502_RS07335	COG4810	utilization protein
IS502_RS07425	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS502_RS07445	COG2837	iron assimilation
IS502_RS07455	COG4150	thiosulfate binding
IS502_RS07460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IS502_RS07465	COG4208	sulfate ABC transporter
IS502_RS07470	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IS502_RS07480	COG4319	ketosteroid isomerase
IS502_RS07515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IS502_RS07535	COG3530	Putative quorum-sensing-regulated virulence factor
IS502_RS07540	COG0385	Bile acid
IS502_RS07545	COG0583	DNA-binding transcription factor activity
IS502_RS07575	COG3415	Transposase
IS502_RS07580	COG3415	Transposase
IS502_RS07595	COG2199	diguanylate cyclase activity
IS502_RS07595	COG2200	EAL domain
IS502_RS07600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS502_RS07615	COG0667	Aldo Keto reductase
IS502_RS07620	COG3961	Belongs to the TPP enzyme family
IS502_RS07635	COG3279	Response regulator of the LytR AlgR family
IS502_RS07640	COG3275	phosphorelay sensor kinase activity
IS502_RS07655	COG0436	Aminotransferase
IS502_RS07665	COG2807	transmembrane transport
IS502_RS07670	COG0590	tRNA wobble adenosine to inosine editing
IS502_RS07675	COG0583	DNA-binding transcription factor activity
IS502_RS07695	COG2116	formate transmembrane transporter activity
IS502_RS07700	COG2853	Lipoprotein
IS502_RS07710	COG3691	Protein conserved in bacteria
IS502_RS07725	COG2062	phosphohistidine phosphatase, SixA
IS502_RS07750	COG0730	response to heat
IS502_RS07755	COG3101	peptidyl-lysine hydroxylation
IS502_RS07770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS502_RS07790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS502_RS07800	COG0586	Pfam SNARE associated Golgi protein
IS502_RS07810	COG0285	dihydrofolate synthase activity
IS502_RS07815	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IS502_RS07820	COG1286	toxin biosynthetic process
IS502_RS07825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IS502_RS07830	COG0163	prenyltransferase activity
IS502_RS07855	COG4160	amino acid transport
IS502_RS07860	COG4598	ABC transporter
IS502_RS07875	COG1090	epimerase
IS502_RS07880	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS502_RS07885	COG0625	glutathione transferase activity
IS502_RS07890	COG0625	glutathione transferase activity
IS502_RS07895	COG0622	Phosphoesterase
IS502_RS07900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IS502_RS07905	COG0857	belongs to the CobB CobQ family
IS502_RS07905	COG0280	phosphate acetyltransferase
IS502_RS07925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS502_RS07930	COG0471	metal ion transport
IS502_RS07930	COG0490	domain, Protein
IS502_RS07940	COG0436	Aminotransferase
IS502_RS07945	COG0583	DNA-binding transcription factor activity
IS502_RS07990	COG0839	Belongs to the complex I subunit 6 family
IS502_RS08000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IS502_RS08005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS502_RS08020	COG2153	protein acetylation
IS502_RS08025	COG1169	isochorismate synthase
IS502_RS08050	COG0318	PFAM AMP-dependent synthetase and ligase
IS502_RS08060	COG5464	transposase or invertase
IS502_RS08075	COG1414	Transcriptional regulator
IS502_RS08085	COG2271	Major facilitator Superfamily
IS502_RS08095	COG0247	lactate metabolic process
IS502_RS08105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS502_RS08115	COG2271	Major facilitator Superfamily
IS502_RS08120	COG0584	glycerophosphoryl diester phosphodiesterase
IS502_RS08125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS502_RS08150	COG2205	protein histidine kinase activity
IS502_RS08150	COG0784	Response regulator, receiver
IS502_RS08160	COG0642	Histidine kinase
IS502_RS08160	COG2198	Histidine kinase
IS502_RS08175	COG2169	Transcriptional regulator
IS502_RS08175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS502_RS08180	COG3145	DNA-N1-methyladenine dioxygenase activity
IS502_RS08185	COG4615	Cyclic peptide transporter
IS502_RS08190	COG2239	Acts as a magnesium transporter
IS502_RS08195	COG0659	secondary active sulfate transmembrane transporter activity
IS502_RS08210	COG0628	permease
IS502_RS08235	COG1349	DNA-binding transcription factor activity
IS502_RS08240	COG0494	nUDIX hydrolase
IS502_RS08260	COG1061	Type III restriction enzyme res subunit
IS502_RS08265	COG1187	pseudouridine synthase activity
IS502_RS08270	COG2814	Major facilitator Superfamily
IS502_RS08280	COG4172	Belongs to the ABC transporter superfamily
IS502_RS08285	COG4239	(ABC) transporter, permease
IS502_RS08290	COG4174	ABC transporter (Permease)
IS502_RS08295	COG4166	transmembrane transport
IS502_RS08300	COG2200	EAL domain
IS502_RS08305	COG0791	NLP P60 protein
IS502_RS08310	COG0671	phosphoesterase, PA-phosphatase related
IS502_RS08315	COG0523	cobalamin synthesis protein
IS502_RS08320	COG0246	Mannitol dehydrogenase
IS502_RS08325	COG1312	Catalyzes the dehydration of D-mannonate
IS502_RS08350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS08350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS08355	COG1105	Belongs to the carbohydrate kinase PfkB family
IS502_RS08360	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS502_RS08360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS502_RS08360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS502_RS08370	COG2855	membrane
IS502_RS08375	COG0583	DNA-binding transcription factor activity
IS502_RS08380	COG0833	amino acid
IS502_RS08390	COG4771	TonB-dependent receptor
IS502_RS08405	COG2311	Membrane
IS502_RS08420	COG1129	ABC transporter
IS502_RS08430	COG2949	membrane
IS502_RS08440	COG1346	cytolysis
IS502_RS08450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS502_RS08455	COG3659	wide pore channel activity
IS502_RS08470	COG2723	6-phospho-beta-galactosidase activity
IS502_RS08475	COG1538	Outer membrane efflux protein
IS502_RS08480	COG0586	Pfam SNARE associated Golgi protein
IS502_RS08490	COG1686	Belongs to the peptidase S11 family
IS502_RS08505	COG0277	FAD linked oxidase domain protein
IS502_RS08510	COG1472	Belongs to the glycosyl hydrolase 3 family
IS502_RS08515	COG1732	Glycine betaine
IS502_RS08520	COG1174	glycine betaine transport
IS502_RS08525	COG1125	glycine betaine transport
IS502_RS08530	COG1174	glycine betaine transport
IS502_RS08540	COG3275	phosphorelay sensor kinase activity
IS502_RS08550	COG4807	Protein conserved in bacteria
IS502_RS08570	COG5455	response to cobalt ion
IS502_RS08575	COG0583	DNA-binding transcription factor activity
IS502_RS08580	COG2252	PERMEase
IS502_RS08590	COG0583	DNA-binding transcription factor activity
IS502_RS08605	COG0351	phosphomethylpyrimidine kinase
IS502_RS08610	COG1830	Aldolase
IS502_RS08620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS502_RS08645	COG1070	Carbohydrate kinase
IS502_RS08655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS502_RS08660	COG4948	Mandelate Racemase Muconate Lactonizing
IS502_RS08665	COG0747	negative chemotaxis
IS502_RS08670	COG0601	transmembrane transport
IS502_RS08675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS502_RS08680	COG0444	Belongs to the ABC transporter superfamily
IS502_RS08685	COG4608	Belongs to the ABC transporter superfamily
IS502_RS08695	COG0826	peptidase U32
IS502_RS08700	COG0745	RESPONSE REGULATOR receiver
IS502_RS08705	COG2205	protein histidine kinase activity
IS502_RS08730	COG1301	dicarboxylic acid transport
IS502_RS08750	COG5002	protein histidine kinase activity
IS502_RS08755	COG0443	Heat shock 70 kDa protein
IS502_RS08760	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IS502_RS08775	COG2982	Protein involved in outer membrane biogenesis
IS502_RS08780	COG1253	flavin adenine dinucleotide binding
IS502_RS08835	COG1215	transferase activity, transferring glycosyl groups
IS502_RS08845	COG0438	transferase activity, transferring glycosyl groups
IS502_RS08880	COG1088	dTDP-glucose 4,6-dehydratase activity
IS502_RS08905	COG3039	Transposase
IS502_RS08955	COG0438	transferase activity, transferring glycosyl groups
IS502_RS08960	COG1215	transferase activity, transferring glycosyl groups
IS502_RS08980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IS502_RS09010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS502_RS09015	COG0583	DNA-binding transcription factor activity
IS502_RS09025	COG0531	amino acid
IS502_RS09030	COG0640	Transcriptional regulator
IS502_RS09035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS502_RS09045	COG2925	Exonuclease
IS502_RS09055	COG3344	reverse transcriptase
IS502_RS09065	COG1289	transmembrane transporter activity
IS502_RS09085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IS502_RS09095	COG1942	4-Oxalocrotonate Tautomerase
IS502_RS09100	COG0583	DNA-binding transcription factor activity
IS502_RS09105	COG0095	Lipoate-protein ligase
IS502_RS09110	COG0477	Major facilitator Superfamily
IS502_RS09120	COG5001	Diguanylate cyclase
IS502_RS09120	COG3300	MHYT domain
IS502_RS09130	COG3615	Tellurite resistance protein tehB
IS502_RS09155	COG3706	GGDEF domain
IS502_RS09205	COG2003	Belongs to the UPF0758 family
IS502_RS09250	COG3504	Conjugal transfer protein
IS502_RS09320	COG4771	TonB-dependent receptor
IS502_RS09325	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS502_RS09345	COG2226	methyltransferase
IS502_RS09345	COG3433	isochorismatase activity
IS502_RS09345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS502_RS09360	COG1132	(ABC) transporter
IS502_RS09365	COG2814	Major facilitator Superfamily
IS502_RS09370	COG1169	isochorismate synthase
IS502_RS09375	COG0582	viral genome integration into host DNA
IS502_RS09385	COG0534	Mate efflux family protein
IS502_RS09395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IS502_RS09415	COG0604	alcohol dehydrogenase
IS502_RS09425	COG0025	NhaP-type Na H and K H
IS502_RS09470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS502_RS09480	COG1418	mRNA catabolic process
IS502_RS09485	COG0270	DNA (cytosine-5-)-methyltransferase activity
IS502_RS09490	COG3727	T/G mismatch-specific endonuclease activity
IS502_RS09495	COG0697	spore germination
IS502_RS09500	COG2354	Protein conserved in bacteria
IS502_RS09530	COG0366	Alpha amylase catalytic
IS502_RS09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS09545	COG0765	amino acid transport
IS502_RS09550	COG1126	abc transporter atp-binding protein
IS502_RS09555	COG2197	response regulator
IS502_RS09565	COG2197	response regulator
IS502_RS09600	COG3012	SEC-C Motif Domain Protein
IS502_RS09600	COG3318	Belongs to the UPF0149 family
IS502_RS09605	COG0814	amino acid
IS502_RS09615	COG1528	Iron-storage protein
IS502_RS09630	COG0477	Major facilitator Superfamily
IS502_RS09640	COG2211	Major facilitator Superfamily
IS502_RS09650	COG1528	Iron-storage protein
IS502_RS09660	COG1879	ABC-type sugar transport system periplasmic component
IS502_RS09670	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS09695	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IS502_RS09705	COG3102	Protein conserved in bacteria
IS502_RS09725	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IS502_RS09730	COG1801	Protein of unknown function DUF72
IS502_RS09735	COG1335	isochorismatase
IS502_RS09745	COG0494	nUDIX hydrolase
IS502_RS09770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS502_RS09780	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IS502_RS09785	COG0739	heme binding
IS502_RS09790	COG1560	Kdo2-lipid A biosynthetic process
IS502_RS09800	COG1737	Transcriptional regulator
IS502_RS09810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS502_RS09815	COG0129	dihydroxy-acid dehydratase activity
IS502_RS09820	COG0800	Aldolase
IS502_RS09830	COG3141	response to X-ray
IS502_RS09835	COG2979	Protein of unknown function (DUF533)
IS502_RS09840	COG1770	oligopeptidase
IS502_RS09845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS502_RS09855	COG2372	response to copper ion
IS502_RS09860	COG1276	copper resistance
IS502_RS09875	COG2990	Protein conserved in bacteria
IS502_RS09900	COG3008	intermembrane lipid transfer
IS502_RS09905	COG2995	paraquat-inducible protein a
IS502_RS09910	COG1956	GAF domain-containing protein
IS502_RS09930	COG2814	Major facilitator Superfamily
IS502_RS09935	COG1414	Transcriptional regulator
IS502_RS09965	COG0768	penicillin binding
IS502_RS09970	COG2226	methyltransferase
IS502_RS09985	COG3716	PTS system mannose fructose sorbose family IID component
IS502_RS09990	COG3715	PTS system
IS502_RS09995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS09995	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS10000	COG1253	flavin adenine dinucleotide binding
IS502_RS10005	COG2200	EAL domain
IS502_RS10010	COG1760	l-serine dehydratase
IS502_RS10030	COG0251	oxidation-reduction process
IS502_RS10035	COG1199	ATP-dependent helicase activity
IS502_RS10045	COG3065	identical protein binding
IS502_RS10055	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IS502_RS10065	COG2894	cell division
IS502_RS10080	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS502_RS10110	COG2719	SpoVR family
IS502_RS10135	COG1619	proteins homologs of microcin C7 resistance protein MccF
IS502_RS10145	COG4774	siderophore transport
IS502_RS10160	COG2308	Evidence 4 Homologs of previously reported genes of
IS502_RS10200	COG0583	DNA-binding transcription factor activity
IS502_RS10205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS502_RS10220	COG1882	Formate acetyltransferase
IS502_RS10255	COG0583	DNA-binding transcription factor activity
IS502_RS10285	COG0583	DNA-binding transcription factor activity
IS502_RS10300	COG3122	Protein conserved in bacteria
IS502_RS10320	COG2885	chlorophyll binding
IS502_RS10470	COG0012	GTP binding
IS502_RS10490	COG0659	secondary active sulfate transmembrane transporter activity
IS502_RS10520	COG2890	protein-(glutamine-N5) methyltransferase activity
IS502_RS10540	COG0387	Pfam Sodium calcium exchanger
IS502_RS10545	COG4572	Cation transport regulator
IS502_RS10550	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IS502_RS10560	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IS502_RS10565	COG3707	response regulator
IS502_RS10570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS502_RS10580	COG1116	anion transmembrane transporter activity
IS502_RS10585	COG2146	nitrite reductase [NAD(P)H] activity
IS502_RS10585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS502_RS10590	COG0243	molybdopterin cofactor binding
IS502_RS10595	COG4932	domain protein
IS502_RS10600	COG2197	response regulator
IS502_RS10605	COG3850	Histidine kinase
IS502_RS10610	COG2223	nitrite transmembrane transporter activity
IS502_RS10620	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS502_RS10625	COG1140	nitrate reductase beta subunit
IS502_RS10630	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS502_RS10635	COG2181	nitrate reductase activity
IS502_RS10645	COG1522	sequence-specific DNA binding
IS502_RS10680	COG0788	formyltetrahydrofolate deformylase activity
IS502_RS10690	COG1752	Esterase of the alpha-beta hydrolase superfamily
IS502_RS10695	COG0745	RESPONSE REGULATOR receiver
IS502_RS10700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IS502_RS10705	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS502_RS10715	COG1435	thymidine kinase activity
IS502_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS10720	COG1454	alcohol dehydrogenase
IS502_RS10730	COG2095	MarC family integral membrane protein
IS502_RS10735	COG4166	transmembrane transport
IS502_RS10740	COG0601	transmembrane transport
IS502_RS10745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS502_RS10750	COG0444	Belongs to the ABC transporter superfamily
IS502_RS10760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS502_RS10780	COG2353	YceI-like domain
IS502_RS10790	COG2350	Protein conserved in bacteria
IS502_RS10800	COG3001	Fructosamine kinase
IS502_RS10810	COG1105	Belongs to the carbohydrate kinase PfkB family
IS502_RS10815	COG3137	Salt-induced outer membrane protein
IS502_RS10855	COG0072	phenylalanine-tRNA ligase activity
IS502_RS10855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS502_RS10875	COG0583	DNA-binding transcription factor activity
IS502_RS10895	COG0386	Belongs to the glutathione peroxidase family
IS502_RS10905	COG0791	NLP P60 protein
IS502_RS10915	COG4256	Hemin uptake protein
IS502_RS10920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS502_RS10935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS502_RS10935	COG0574	Belongs to the PEP-utilizing enzyme family
IS502_RS10945	COG0628	permease
IS502_RS10950	COG0277	FAD linked oxidase domain protein
IS502_RS10950	COG0247	lactate metabolic process
IS502_RS10955	COG2050	protein possibly involved in aromatic compounds catabolism
IS502_RS10960	COG2261	transglycosylase associated protein
IS502_RS10985	COG1120	ATPase activity
IS502_RS10990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS11000	COG0583	DNA-binding transcription factor activity
IS502_RS11025	COG1304	FMN binding
IS502_RS11030	COG1309	transcriptional regulator
IS502_RS11050	COG0316	Belongs to the HesB IscA family
IS502_RS11055	COG0719	Fe-S assembly protein
IS502_RS11060	COG0396	ATPase activity
IS502_RS11065	COG0719	Fe-S assembly protein
IS502_RS11080	COG1376	ErfK ybiS ycfS ynhG family protein
IS502_RS11110	COG1309	transcriptional regulator
IS502_RS11115	COG1082	Xylose isomerase domain protein TIM barrel
IS502_RS11115	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IS502_RS11120	COG2271	Major facilitator Superfamily
IS502_RS11125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS502_RS11135	COG1120	ATPase activity
IS502_RS11140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS11145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS502_RS11150	COG1414	Transcriptional regulator
IS502_RS11185	COG2814	Major facilitator Superfamily
IS502_RS11205	COG0583	DNA-binding transcription factor activity
IS502_RS11210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS502_RS11230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS502_RS11235	COG1116	anion transmembrane transporter activity
IS502_RS11240	COG4774	siderophore transport
IS502_RS11245	COG1120	ATPase activity
IS502_RS11250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS11255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS11275	COG0765	amino acid transport
IS502_RS11280	COG1126	abc transporter atp-binding protein
IS502_RS11320	COG3383	formate dehydrogenase (NAD+) activity
IS502_RS11325	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IS502_RS11335	COG1175	transmembrane transport
IS502_RS11365	COG4133	protoheme IX ABC transporter activity
IS502_RS11370	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS502_RS11375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS502_RS11390	COG1138	Cytochrome C-type biogenesis protein
IS502_RS11395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS502_RS11400	COG4235	cytochrome complex assembly
IS502_RS11400	COG3088	subunit of a heme lyase
IS502_RS11420	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IS502_RS11455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS502_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS11490	COG2610	gluconate transmembrane transporter activity
IS502_RS11495	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS502_RS11505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS502_RS11515	COG0583	DNA-binding transcription factor activity
IS502_RS11540	COG0277	FAD linked oxidase domain protein
IS502_RS11545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS502_RS11570	COG0402	S-adenosylhomocysteine deaminase activity
IS502_RS11615	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS11615	COG3321	synthase
IS502_RS11615	COG0604	alcohol dehydrogenase
IS502_RS11645	COG4608	Belongs to the ABC transporter superfamily
IS502_RS11650	COG0444	Belongs to the ABC transporter superfamily
IS502_RS11675	COG0346	lactoylglutathione lyase activity
IS502_RS11680	COG1349	DNA-binding transcription factor activity
IS502_RS11715	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IS502_RS11765	COG0307	riboflavin synthase, alpha
IS502_RS11770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS502_RS11775	COG2814	Major facilitator Superfamily
IS502_RS11780	COG0583	DNA-binding transcription factor activity
IS502_RS11795	COG2814	Major facilitator Superfamily
IS502_RS11810	COG0791	NLP P60 protein
IS502_RS11815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS502_RS11825	COG0346	lactoylglutathione lyase activity
IS502_RS11830	COG1902	pentaerythritol trinitrate reductase activity
IS502_RS11835	COG1309	transcriptional regulator
IS502_RS11840	COG3313	Fe-S protein
IS502_RS11845	COG4989	oxidoreductase activity
IS502_RS11850	COG2032	superoxide dismutase activity
IS502_RS11855	COG1289	transmembrane transporter activity
IS502_RS11860	COG1566	PFAM secretion protein HlyD family protein
IS502_RS11875	COG3706	GGDEF domain
IS502_RS11890	COG3895	Periplasmic Protein
IS502_RS11905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IS502_RS11910	COG0625	glutathione transferase activity
IS502_RS11920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IS502_RS11930	COG4659	FMN binding
IS502_RS11965	COG2723	6-phospho-beta-galactosidase activity
IS502_RS11975	COG0673	inositol 2-dehydrogenase activity
IS502_RS11985	COG2814	Major facilitator Superfamily
IS502_RS12005	COG3038	cytochrome b561
IS502_RS12025	COG0583	DNA-binding transcription factor activity
IS502_RS12030	COG3485	protocatechuate 3,4-dioxygenase
IS502_RS12035	COG3485	protocatechuate 3,4-dioxygenase
IS502_RS12040	COG5383	Protein conserved in bacteria
IS502_RS12045	COG2272	Belongs to the type-B carboxylesterase lipase family
IS502_RS12060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS502_RS12065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS502_RS12070	COG1275	C4-dicarboxylate transporter malic acid transport protein
IS502_RS12075	COG0500	methyltransferase
IS502_RS12090	COG2207	Transcriptional regulator
IS502_RS12090	COG3708	Transcriptional regulator
IS502_RS12095	COG3135	benzoate transporter
IS502_RS12100	COG1396	sequence-specific DNA binding
IS502_RS12110	COG0826	peptidase U32
IS502_RS12130	COG1294	oxidase, subunit
IS502_RS12135	COG1271	oxidase subunit
IS502_RS12140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS502_RS12145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS502_RS12150	COG3842	ATPase activity
IS502_RS12155	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS502_RS12160	COG1177	transmembrane transport
IS502_RS12165	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS12200	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS12205	COG0747	negative chemotaxis
IS502_RS12215	COG3238	Protein conserved in bacteria
IS502_RS12220	COG1247	-acetyltransferase
IS502_RS12230	COG2130	NADP-dependent
IS502_RS12245	COG3691	Protein conserved in bacteria
IS502_RS12250	COG1228	amidohydrolase
IS502_RS12255	COG4772	TonB-dependent receptor
IS502_RS12280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS502_RS12285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS502_RS12290	COG1473	amidohydrolase
IS502_RS12295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS502_RS12300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS12310	COG0765	amino acid transport
IS502_RS12315	COG1126	abc transporter atp-binding protein
IS502_RS12325	COG0625	glutathione transferase activity
IS502_RS12360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS502_RS12365	COG3842	ATPase activity
IS502_RS12370	COG1840	ABC-type Fe3 transport system, periplasmic component
IS502_RS12375	COG1178	ABC-type Fe3 transport system permease component
IS502_RS12380	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IS502_RS12385	COG2181	nitrate reductase activity
IS502_RS12390	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS502_RS12395	COG1140	nitrate reductase beta subunit
IS502_RS12400	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS502_RS12420	COG1414	Transcriptional regulator
IS502_RS12425	COG4948	Mandelate Racemase Muconate Lactonizing
IS502_RS12430	COG4829	muconolactone delta-isomerase
IS502_RS12435	COG3485	protocatechuate 3,4-dioxygenase
IS502_RS12445	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IS502_RS12470	COG0437	4 iron, 4 sulfur cluster binding
IS502_RS12475	COG2864	formate dehydrogenase
IS502_RS12490	COG2326	polyphosphate kinase activity
IS502_RS12500	COG2814	Major facilitator Superfamily
IS502_RS12510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS502_RS12520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS502_RS12530	COG0747	negative chemotaxis
IS502_RS12535	COG1064	alcohol dehydrogenase
IS502_RS12550	COG0488	(ABC) transporter
IS502_RS12595	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS12600	COG3729	General stress protein
IS502_RS12610	COG3685	Protein conserved in bacteria
IS502_RS12620	COG0366	Alpha amylase catalytic
IS502_RS12630	COG2323	membrane
IS502_RS12640	COG3111	PFAM Bacterial OB fold (BOF) protein
IS502_RS12655	COG1764	response to oxidative stress
IS502_RS12680	COG3781	membrane
IS502_RS12685	COG0243	molybdopterin cofactor binding
IS502_RS12690	COG0583	DNA-binding transcription factor activity
IS502_RS12695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS12720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS12725	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS502_RS12730	COG2814	Major facilitator Superfamily
IS502_RS12735	COG1285	pathogenesis
IS502_RS12740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS502_RS12750	COG0583	DNA-binding transcription factor activity
IS502_RS12770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS502_RS12770	COG0519	Catalyzes the synthesis of GMP from XMP
IS502_RS12810	COG0596	Alpha beta hydrolase
IS502_RS12820	COG2205	protein histidine kinase activity
IS502_RS12835	COG0076	glutamate decarboxylase activity
IS502_RS12840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS502_RS12845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS502_RS12850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS502_RS12855	COG1116	anion transmembrane transporter activity
IS502_RS12860	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IS502_RS12875	COG0673	inositol 2-dehydrogenase activity
IS502_RS12885	COG1609	Transcriptional regulator
IS502_RS12890	COG3706	GGDEF domain
IS502_RS12895	COG0402	S-adenosylhomocysteine deaminase activity
IS502_RS12900	COG1953	Uracil, thiamine, allantoin
IS502_RS12940	COG0406	alpha-ribazole phosphatase activity
IS502_RS12945	COG1335	isochorismatase
IS502_RS12975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS502_RS13045	COG0765	amino acid transport
IS502_RS13055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IS502_RS13065	COG2070	2-Nitropropane dioxygenase
IS502_RS13070	COG0583	DNA-binding transcription factor activity
IS502_RS13080	COG1902	pentaerythritol trinitrate reductase activity
IS502_RS13085	COG4529	Protein conserved in bacteria
IS502_RS13090	COG0477	Major facilitator Superfamily
IS502_RS13120	COG2223	nitrite transmembrane transporter activity
IS502_RS13130	COG1609	Transcriptional regulator
IS502_RS13135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS13145	COG3037	sugar-specific permease SgaT UlaA
IS502_RS13150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS502_RS13160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS502_RS13165	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS502_RS13165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS502_RS13165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS502_RS13180	COG0583	DNA-binding transcription factor activity
IS502_RS13185	COG0583	DNA-binding transcription factor activity
IS502_RS13190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS502_RS13200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS502_RS13215	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS13225	COG1609	Transcriptional regulator
IS502_RS13255	COG1652	LysM domain
IS502_RS13270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS502_RS13270	COG0426	domain, Protein
IS502_RS13295	COG0456	acetyltransferase
IS502_RS13295	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IS502_RS13305	COG0667	Aldo Keto reductase
IS502_RS13310	COG0667	Aldo Keto reductase
IS502_RS13320	COG0667	Aldo Keto reductase
IS502_RS13340	COG4977	sequence-specific DNA binding
IS502_RS13360	COG4977	sequence-specific DNA binding
IS502_RS13365	COG1349	DNA-binding transcription factor activity
IS502_RS13380	COG1349	DNA-binding transcription factor activity
IS502_RS13385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS502_RS13390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS13395	COG0738	Major facilitator superfamily
IS502_RS13440	COG1929	Belongs to the glycerate kinase type-1 family
IS502_RS13445	COG3835	regulator
IS502_RS13465	COG2186	Transcriptional regulator
IS502_RS13470	COG1263	PTS System
IS502_RS13470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS13480	COG2814	Major facilitator Superfamily
IS502_RS13485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS13485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS13500	COG2819	hydrolase of the alpha beta superfamily
IS502_RS13505	COG3300	MHYT domain
IS502_RS13505	COG5001	Diguanylate cyclase
IS502_RS13545	COG3188	usher protein
IS502_RS13555	COG1649	PFAM Uncharacterised BCR, COG1649
IS502_RS13560	COG3550	peptidyl-serine autophosphorylation
IS502_RS13565	COG1396	sequence-specific DNA binding
IS502_RS13570	COG2351	hydroxyisourate hydrolase activity
IS502_RS13575	COG3648	Uricase
IS502_RS13575	COG3195	allantoin biosynthetic process
IS502_RS13580	COG2233	PERMEase
IS502_RS13610	COG2207	Transcriptional regulator
IS502_RS13625	COG4628	conserved protein (DUF2132)
IS502_RS13645	COG2011	ABC-type metal ion transport system permease component
IS502_RS13650	COG2070	2-Nitropropane dioxygenase
IS502_RS13660	COG0477	Major facilitator Superfamily
IS502_RS13730	COG2199	diguanylate cyclase activity
IS502_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS13750	COG0583	DNA-binding transcription factor activity
IS502_RS13760	COG0039	L-malate dehydrogenase activity
IS502_RS13765	COG1349	DNA-binding transcription factor activity
IS502_RS13770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS502_RS13775	COG3395	kinase activity
IS502_RS13785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS502_RS13800	COG2731	YhcH YjgK YiaL family protein
IS502_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS13835	COG4977	sequence-specific DNA binding
IS502_RS13845	COG0697	spore germination
IS502_RS13850	COG2814	Major facilitator Superfamily
IS502_RS13860	COG0410	ABC transporter
IS502_RS13865	COG1129	ABC transporter
IS502_RS13880	COG0683	leucine binding
IS502_RS13885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IS502_RS13920	COG2223	nitrite transmembrane transporter activity
IS502_RS13925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IS502_RS13940	COG1349	DNA-binding transcription factor activity
IS502_RS13945	COG2084	Dehydrogenase
IS502_RS13950	COG3395	kinase activity
IS502_RS13955	COG0235	Class ii aldolase
IS502_RS13960	COG3622	Belongs to the hyi family
IS502_RS13965	COG2610	gluconate transmembrane transporter activity
IS502_RS13970	COG2207	Transcriptional regulator
IS502_RS13970	COG3708	Transcriptional regulator
IS502_RS13985	COG2200	EAL domain
IS502_RS13990	COG1546	Belongs to the CinA family
IS502_RS13995	COG0071	Belongs to the small heat shock protein (HSP20) family
IS502_RS14010	COG2197	response regulator
IS502_RS14025	COG2135	peptidase activity
IS502_RS14030	COG2207	Transcriptional regulator
IS502_RS14045	COG4221	oxidoreductase activity
IS502_RS14050	COG1802	Transcriptional regulator
IS502_RS14055	COG0589	response to stress
IS502_RS14060	COG0246	Mannitol dehydrogenase
IS502_RS14065	COG2271	Major facilitator Superfamily
IS502_RS14080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS502_RS14095	COG0243	molybdopterin cofactor binding
IS502_RS14100	COG0437	4 iron, 4 sulfur cluster binding
IS502_RS14105	COG3302	dmso reductase anchor subunit
IS502_RS14120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IS502_RS14125	COG1940	carbohydrate kinase activity
IS502_RS14130	COG0583	DNA-binding transcription factor activity
IS502_RS14135	COG2814	Major facilitator Superfamily
IS502_RS14140	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IS502_RS14150	COG3591	Belongs to the peptidase S1B family
IS502_RS14170	COG0628	permease
IS502_RS14200	COG0679	Auxin Efflux Carrier
IS502_RS14210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS502_RS14235	COG3290	protein histidine kinase activity
IS502_RS14240	COG4565	transcriptional regulatory protein
IS502_RS14260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS502_RS14260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS502_RS14270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS502_RS14275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS502_RS14285	COG0183	Belongs to the thiolase family
IS502_RS14290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS502_RS14300	COG1414	Transcriptional regulator
IS502_RS14305	COG2840	Smr protein MutS2
IS502_RS14310	COG0583	DNA-binding transcription factor activity
IS502_RS14320	COG1473	amidohydrolase
IS502_RS14325	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IS502_RS14340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS502_RS14355	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IS502_RS14360	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IS502_RS14375	COG0531	amino acid
IS502_RS14385	COG3136	membrane protein required for alginate biosynthesis
IS502_RS14390	COG0745	RESPONSE REGULATOR receiver
IS502_RS14400	COG2205	protein histidine kinase activity
IS502_RS14410	COG0114	fumarate hydratase activity
IS502_RS14415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS502_RS14415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS502_RS14420	COG1482	cell wall glycoprotein biosynthetic process
IS502_RS14425	COG5339	Protein conserved in bacteria
IS502_RS14430	COG1609	Transcriptional regulator
IS502_RS14435	COG1263	PTS System
IS502_RS14435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS14440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS502_RS14465	COG2391	methyltransferase activity
IS502_RS14470	COG0425	Belongs to the sulfur carrier protein TusA family
IS502_RS14475	COG5562	phage envelope protein
IS502_RS14480	COG0401	homolog of Blt101
IS502_RS14485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS502_RS14490	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS14500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS502_RS14505	COG0477	Major facilitator Superfamily
IS502_RS14510	COG1113	amino acid transport
IS502_RS14515	COG2988	succinylglutamate desuccinylase activity
IS502_RS14520	COG3724	N-succinylarginine dihydrolase activity
IS502_RS14525	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS14530	COG3138	arginine N-succinyltransferase
IS502_RS14535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS502_RS14545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS502_RS14550	COG0667	Aldo Keto reductase
IS502_RS14555	COG0583	DNA-binding transcription factor activity
IS502_RS14580	COG4122	O-methyltransferase activity
IS502_RS14585	COG1643	Atp-dependent helicase
IS502_RS14600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS502_RS14605	COG3327	negative regulation of DNA-templated transcription, initiation
IS502_RS14610	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IS502_RS14615	COG0183	Belongs to the thiolase family
IS502_RS14620	COG2050	protein possibly involved in aromatic compounds catabolism
IS502_RS14625	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS502_RS14630	COG1024	Enoyl-CoA hydratase
IS502_RS14635	COG1024	Enoyl-CoA hydratase
IS502_RS14640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS502_RS14645	COG2151	metal-sulfur cluster biosynthetic enzyme
IS502_RS14650	COG3396	Phenylacetate-CoA oxygenase
IS502_RS14655	COG3460	Phenylacetate-CoA oxygenase
IS502_RS14660	COG3396	Phenylacetate-CoA oxygenase
IS502_RS14665	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS14665	COG2030	dehydratase
IS502_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS14690	COG2207	Transcriptional regulator
IS502_RS14695	COG3784	Protein of unknown function (DUF1318)
IS502_RS14705	COG2911	Protein conserved in bacteria
IS502_RS14710	COG0586	Pfam SNARE associated Golgi protein
IS502_RS14715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS502_RS14720	COG3187	Heat shock protein
IS502_RS14725	COG3042	response to heat
IS502_RS14730	COG0674	pyruvate-flavodoxin oxidoreductase activity
IS502_RS14730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS502_RS14730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IS502_RS14730	COG1013	pyruvate-flavodoxin oxidoreductase activity
IS502_RS14735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS502_RS14745	COG0589	response to stress
IS502_RS14755	COG0513	Belongs to the DEAD box helicase family
IS502_RS14765	COG1349	DNA-binding transcription factor activity
IS502_RS14770	COG0673	inositol 2-dehydrogenase activity
IS502_RS14785	COG1113	amino acid transport
IS502_RS14790	COG1522	sequence-specific DNA binding
IS502_RS14800	COG1448	Aminotransferase
IS502_RS14805	COG2011	ABC-type metal ion transport system permease component
IS502_RS14820	COG0436	Aminotransferase
IS502_RS14825	COG0604	alcohol dehydrogenase
IS502_RS14855	COG0583	DNA-binding transcription factor activity
IS502_RS14875	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS14880	COG1309	transcriptional regulator
IS502_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS14980	COG2885	chlorophyll binding
IS502_RS15020	COG3344	reverse transcriptase
IS502_RS15105	COG0741	lytic transglycosylase activity
IS502_RS15105	COG1196	nuclear chromosome segregation
IS502_RS15105	COG0739	heme binding
IS502_RS15175	COG3567	Phage-associated protein, HI1409 family
IS502_RS15180	COG1783	phage Terminase large subunit
IS502_RS15200	COG3772	lysozyme
IS502_RS15210	COG0484	heat shock protein binding
IS502_RS15315	COG0582	viral genome integration into host DNA
IS502_RS15320	COG0693	protein deglycase activity
IS502_RS15325	COG1078	dGTPase activity
IS502_RS15330	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS15335	COG0583	DNA-binding transcription factor activity
IS502_RS15355	COG0656	L-ascorbic acid biosynthetic process
IS502_RS15385	COG4166	transmembrane transport
IS502_RS15395	COG2866	Carboxypeptidase
IS502_RS15400	COG4948	Mandelate Racemase Muconate Lactonizing
IS502_RS15405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IS502_RS15410	COG3180	Ammonia monooxygenase
IS502_RS15420	COG1486	melibiose metabolic process
IS502_RS15425	COG0583	DNA-binding transcription factor activity
IS502_RS15435	COG3106	COG3106 Predicted ATPase
IS502_RS15445	COG1983	PspC domain protein
IS502_RS15455	COG1842	Phage shock protein A
IS502_RS15460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS502_RS15470	COG1473	amidohydrolase
IS502_RS15485	COG0702	epimerase
IS502_RS15500	COG4171	peptide transport system, permease
IS502_RS15515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS502_RS15525	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS502_RS15530	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS502_RS15530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS502_RS15545	COG1349	DNA-binding transcription factor activity
IS502_RS15555	COG0023	Translation Initiation Factor
IS502_RS15565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IS502_RS15570	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IS502_RS15575	COG0671	phosphoesterase, PA-phosphatase related
IS502_RS15585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IS502_RS15610	COG0616	signal peptide processing
IS502_RS15620	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS15625	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IS502_RS15635	COG0583	DNA-binding transcription factor activity
IS502_RS15645	COG0009	L-threonylcarbamoyladenylate synthase
IS502_RS15655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IS502_RS15660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS502_RS15660	COG0512	Glutamine amidotransferase of anthranilate synthase
IS502_RS15665	COG0134	indole-3-glycerol-phosphate synthase activity
IS502_RS15665	COG0135	phosphoribosylanthranilate isomerase activity
IS502_RS15720	COG4774	siderophore transport
IS502_RS15730	COG3047	cAMP biosynthetic process
IS502_RS15735	COG0727	PFAM Uncharacterised protein family (UPF0153)
IS502_RS15765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS502_RS15770	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS15775	COG1988	membrane-bound metal-dependent
IS502_RS15780	COG1823	symporter activity
IS502_RS15790	COG0753	catalase activity
IS502_RS15800	COG1486	melibiose metabolic process
IS502_RS15805	COG1917	Cupin 2, conserved barrel domain protein
IS502_RS15805	COG2169	Transcriptional regulator
IS502_RS15810	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS502_RS15815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS15825	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS15830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS502_RS15840	COG0322	excinuclease ABC activity
IS502_RS15845	COG3678	ATP-independent chaperone mediated protein folding
IS502_RS15855	COG3724	N-succinylarginine dihydrolase activity
IS502_RS15865	COG3138	arginine N-succinyltransferase
IS502_RS15875	COG0708	Exodeoxyribonuclease III
IS502_RS15880	COG0398	Pfam SNARE associated Golgi protein
IS502_RS15885	COG0398	Pfam SNARE associated Golgi protein
IS502_RS15890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS502_RS15895	COG4134	Bacterial extracellular solute-binding protein
IS502_RS15900	COG4135	transport system, permease component
IS502_RS15905	COG4136	ATPase activity
IS502_RS15910	COG2897	thiosulfate sulfurtransferase activity
IS502_RS15915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS502_RS15920	COG0494	nUDIX hydrolase
IS502_RS15925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS502_RS15930	COG0604	alcohol dehydrogenase
IS502_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS15930	COG3321	synthase
IS502_RS15935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS502_RS15940	COG0709	Synthesizes selenophosphate from selenide and ATP
IS502_RS15955	COG0778	Nitroreductase
IS502_RS15960	COG0616	signal peptide processing
IS502_RS15965	COG0252	asparaginase activity
IS502_RS15970	COG1335	isochorismatase
IS502_RS15975	COG2814	Major facilitator Superfamily
IS502_RS15980	COG1349	DNA-binding transcription factor activity
IS502_RS15985	COG0667	Aldo Keto reductase
IS502_RS15990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS15995	COG0191	fructose-bisphosphate aldolase activity
IS502_RS16000	COG1063	alcohol dehydrogenase
IS502_RS16005	COG2271	Major facilitator Superfamily
IS502_RS16010	COG1063	alcohol dehydrogenase
IS502_RS16025	COG3139	Protein of unknown function (DUF1315)
IS502_RS16050	COG3713	MltA-interacting MipA family protein
IS502_RS16055	COG2766	serine protein kinase
IS502_RS16070	COG0386	Belongs to the glutathione peroxidase family
IS502_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS16100	COG0583	DNA-binding transcription factor activity
IS502_RS16105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS502_RS16110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS502_RS16115	COG3344	reverse transcriptase
IS502_RS16120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IS502_RS16130	COG3344	reverse transcriptase
IS502_RS16165	COG1396	sequence-specific DNA binding
IS502_RS16185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS502_RS16195	COG0582	viral genome integration into host DNA
IS502_RS16200	COG0538	isocitrate dehydrogenase activity
IS502_RS16220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS502_RS16225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS502_RS16230	COG3344	reverse transcriptase
IS502_RS16280	COG1196	nuclear chromosome segregation
IS502_RS16320	COG0740	serine-type endopeptidase activity
IS502_RS16395	COG1403	HNH endonuclease
IS502_RS16400	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IS502_RS16430	COG1396	sequence-specific DNA binding
IS502_RS16485	COG0582	viral genome integration into host DNA
IS502_RS16490	COG0538	isocitrate dehydrogenase activity
IS502_RS16495	COG1187	pseudouridine synthase activity
IS502_RS16515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IS502_RS16535	COG2205	protein histidine kinase activity
IS502_RS16540	COG2850	peptidyl-arginine hydroxylation
IS502_RS16560	COG1177	transmembrane transport
IS502_RS16575	COG0318	PFAM AMP-dependent synthetase and ligase
IS502_RS16585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IS502_RS16595	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS502_RS16605	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS502_RS16615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IS502_RS16620	COG1388	LysM domain
IS502_RS16620	COG1376	ErfK ybiS ycfS ynhG family protein
IS502_RS16635	COG1309	transcriptional regulator
IS502_RS16650	COG3134	Outer membrane lipoprotein
IS502_RS16655	COG1252	NADH dehydrogenase
IS502_RS16680	COG5633	Lipoprotein
IS502_RS16685	COG0537	adenosine 5'-monophosphoramidase activity
IS502_RS16695	COG0084	hydrolase, TatD family'
IS502_RS16700	COG0470	DNA polymerase III
IS502_RS16710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IS502_RS16715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS502_RS16720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS502_RS16735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS502_RS16755	COG1399	metal-binding, possibly nucleic acid-binding protein
IS502_RS16775	COG1530	ribonuclease E activity
IS502_RS16780	COG0583	DNA-binding transcription factor activity
IS502_RS16785	COG2814	Major facilitator Superfamily
IS502_RS16805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS502_RS16850	COG1560	Kdo2-lipid A biosynthetic process
IS502_RS16865	COG5645	(Lipo)protein
IS502_RS16900	COG3381	protein complex oligomerization
IS502_RS16930	COG0583	DNA-binding transcription factor activity
IS502_RS16940	COG1335	isochorismatase
IS502_RS16950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS502_RS16955	COG1702	phosphate starvation-inducible protein PhoH
IS502_RS16975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS502_RS16985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS502_RS17000	COG1309	transcriptional regulator
IS502_RS17035	COG2233	PERMEase
IS502_RS17045	COG3729	General stress protein
IS502_RS17075	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS17090	COG0531	amino acid
IS502_RS17095	COG0174	glutamine synthetase
IS502_RS17100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IS502_RS17105	COG1917	Cupin 2, conserved barrel domain protein
IS502_RS17105	COG1396	sequence-specific DNA binding
IS502_RS17110	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS17115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS502_RS17120	COG0583	DNA-binding transcription factor activity
IS502_RS17125	COG0473	3-isopropylmalate dehydrogenase activity
IS502_RS17130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS502_RS17135	COG4638	Rieske (2fe-2S)
IS502_RS17140	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS17145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS502_RS17175	COG0670	Belongs to the BI1 family
IS502_RS17190	COG2207	Transcriptional regulator
IS502_RS17195	COG1881	PFAM PEBP family protein
IS502_RS17210	COG1832	CoA-binding protein
IS502_RS17220	COG0210	DNA helicase
IS502_RS17225	COG3304	Inner membrane component domain
IS502_RS17230	COG1289	transmembrane transporter activity
IS502_RS17235	COG3070	regulator of competence-specific genes
IS502_RS17255	COG1067	ATP-dependent peptidase activity
IS502_RS17265	COG3130	regulation of translation
IS502_RS17270	COG3009	Protein conserved in bacteria
IS502_RS17275	COG3008	intermembrane lipid transfer
IS502_RS17275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS502_RS17280	COG2995	paraquat-inducible protein a
IS502_RS17285	COG0488	(ABC) transporter
IS502_RS17295	COG3217	Mosc domain protein beta barrel domain protein
IS502_RS17295	COG0633	Ferredoxin
IS502_RS17310	COG0431	NADPH-dependent FMN reductase
IS502_RS17315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS502_RS17320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS502_RS17325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS502_RS17335	COG0308	aminopeptidase N
IS502_RS17345	COG1473	amidohydrolase
IS502_RS17355	COG0814	amino acid
IS502_RS17380	COG1448	Aminotransferase
IS502_RS17385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS502_RS17390	COG3108	Peptidase M15
IS502_RS17395	COG2989	Protein conserved in bacteria
IS502_RS17405	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IS502_RS17415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS502_RS17420	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS502_RS17425	COG3173	Aminoglycoside phosphotransferase
IS502_RS17440	COG3214	Protein conserved in bacteria
IS502_RS17455	COG0658	competence protein
IS502_RS17455	COG2333	competence protein COMEC
IS502_RS17465	COG0539	negative regulation of cytoplasmic translation
IS502_RS17485	COG2323	membrane
IS502_RS17490	COG1944	ATP diphosphatase activity
IS502_RS17495	COG2116	formate transmembrane transporter activity
IS502_RS17500	COG1882	Formate acetyltransferase
IS502_RS17505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS502_RS17510	COG0477	Major facilitator Superfamily
IS502_RS17515	COG3302	dmso reductase anchor subunit
IS502_RS17520	COG0437	4 iron, 4 sulfur cluster binding
IS502_RS17525	COG0243	molybdopterin cofactor binding
IS502_RS17535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IS502_RS17545	COG1674	ftsk spoiiie
IS502_RS17545	COG1178	ABC-type Fe3 transport system permease component
IS502_RS17555	COG0492	ferredoxin-NADP+ reductase activity
IS502_RS17560	COG4988	ABC transporter
IS502_RS17565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IS502_RS17580	COG0542	response to heat
IS502_RS17590	COG1278	Cold shock
IS502_RS17600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS17605	COG3593	DNA synthesis involved in DNA repair
IS502_RS17615	COG2431	L-lysine efflux transmembrane transporter activity
IS502_RS17625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS502_RS17635	COG0028	Belongs to the TPP enzyme family
IS502_RS17640	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IS502_RS17645	COG0702	epimerase
IS502_RS17650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS502_RS17655	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS502_RS17660	COG5001	Diguanylate cyclase
IS502_RS17660	COG2203	Gaf domain
IS502_RS17660	COG3706	GGDEF domain
IS502_RS17660	COG4251	negative regulation of phosphorylation
IS502_RS17670	COG1126	abc transporter atp-binding protein
IS502_RS17675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS17680	COG4215	(ABC) transporter
IS502_RS17685	COG4160	amino acid transport
IS502_RS17690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS17695	COG5002	protein histidine kinase activity
IS502_RS17700	COG0745	RESPONSE REGULATOR receiver
IS502_RS17715	COG1177	transmembrane transport
IS502_RS17720	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS502_RS17725	COG3842	ATPase activity
IS502_RS17730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS502_RS17925	COG4695	Portal protein
IS502_RS17960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS502_RS18000	COG3344	reverse transcriptase
IS502_RS18005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS502_RS18010	COG3226	Transcriptional regulator
IS502_RS18015	COG0738	Major facilitator superfamily
IS502_RS18020	COG0561	phosphatase activity
IS502_RS18025	COG2814	Major facilitator Superfamily
IS502_RS18030	COG0671	phosphoesterase, PA-phosphatase related
IS502_RS18035	COG1349	DNA-binding transcription factor activity
IS502_RS18040	COG1686	Belongs to the peptidase S11 family
IS502_RS18050	COG0625	glutathione transferase activity
IS502_RS18055	COG2133	pyrroloquinoline quinone binding
IS502_RS18065	COG2223	nitrite transmembrane transporter activity
IS502_RS18085	COG0747	negative chemotaxis
IS502_RS18100	COG0303	'Molybdopterin
IS502_RS18105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS502_RS18110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS502_RS18115	COG1882	Formate acetyltransferase
IS502_RS18120	COG0561	phosphatase activity
IS502_RS18130	COG1609	Transcriptional regulator
IS502_RS18135	COG2271	Major facilitator Superfamily
IS502_RS18145	COG0488	(ABC) transporter
IS502_RS18150	COG2365	Tyrosine phosphatase family
IS502_RS18155	COG1376	ErfK ybiS ycfS ynhG family protein
IS502_RS18160	COG2188	Transcriptional regulator
IS502_RS18165	COG2723	6-phospho-beta-galactosidase activity
IS502_RS18170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS502_RS18175	COG1321	iron dependent repressor
IS502_RS18185	COG2194	sulfuric ester hydrolase activity
IS502_RS18190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IS502_RS18205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS18210	COG0765	amino acid transport
IS502_RS18215	COG1126	abc transporter atp-binding protein
IS502_RS18220	COG0668	transmembrane transport
IS502_RS18230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS502_RS18240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS502_RS18250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS502_RS18255	COG1199	ATP-dependent helicase activity
IS502_RS18260	COG0513	Belongs to the DEAD box helicase family
IS502_RS18265	COG3958	Transketolase
IS502_RS18270	COG3959	Transketolase, thiamine diphosphate binding domain
IS502_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS18280	COG2271	Major facilitator Superfamily
IS502_RS18290	COG0583	DNA-binding transcription factor activity
IS502_RS18295	COG1309	transcriptional regulator
IS502_RS18300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS18305	COG1131	(ABC) transporter
IS502_RS18310	COG0842	Transport permease protein
IS502_RS18315	COG0842	Transport permease protein
IS502_RS18325	COG3568	Endonuclease Exonuclease Phosphatase
IS502_RS18330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS502_RS18335	COG0392	lysyltransferase activity
IS502_RS18340	COG0670	Belongs to the BI1 family
IS502_RS18345	COG0314	molybdopterin synthase activity
IS502_RS18350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IS502_RS18360	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS502_RS18380	COG0745	RESPONSE REGULATOR receiver
IS502_RS18385	COG0642	Histidine kinase
IS502_RS18410	COG2226	methyltransferase
IS502_RS18425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS502_RS18430	COG1881	PFAM PEBP family protein
IS502_RS18470	COG4677	pectinesterase activity
IS502_RS18505	COG0789	Transcriptional regulator
IS502_RS18510	COG2200	EAL domain
IS502_RS18535	COG0561	phosphatase activity
IS502_RS18540	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IS502_RS18545	COG4149	molybdate abc transporter
IS502_RS18550	COG0725	ABC transporter, periplasmic molybdate-binding protein
IS502_RS18560	COG3585	molybdate ion transport
IS502_RS18560	COG2005	Transcriptional regulator
IS502_RS18565	COG1119	ATPase activity
IS502_RS18575	COG1085	galactose-1-phosphate uridylyltransferase
IS502_RS18585	COG2017	converts alpha-aldose to the beta-anomer
IS502_RS18595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS502_RS18610	COG3201	nicotinamide mononucleotide transporter
IS502_RS18615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IS502_RS18655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IS502_RS18660	COG2885	chlorophyll binding
IS502_RS18670	COG3064	Membrane
IS502_RS18675	COG0848	biopolymer transport protein
IS502_RS18680	COG0811	peptide transport
IS502_RS18685	COG0824	Thioesterase
IS502_RS18690	COG3790	cyd operon protein YbgE
IS502_RS18695	COG4890	Cyd operon protein YbgT
IS502_RS18700	COG1294	oxidase, subunit
IS502_RS18705	COG1271	oxidase subunit
IS502_RS18710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS502_RS18720	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS502_RS18725	COG0567	Dehydrogenase, E1 component
IS502_RS18730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS502_RS18735	COG1053	succinate dehydrogenase
IS502_RS18740	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IS502_RS18745	COG2009	succinate dehydrogenase
IS502_RS18780	COG1984	allophanate hydrolase subunit 2
IS502_RS18785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IS502_RS18800	COG0415	Belongs to the DNA photolyase family
IS502_RS18830	COG2205	protein histidine kinase activity
IS502_RS18835	COG0745	RESPONSE REGULATOR receiver
IS502_RS18845	COG0033	Phosphoglucomutase
IS502_RS18855	COG0596	Alpha beta hydrolase
IS502_RS18870	COG0735	belongs to the Fur family
IS502_RS18910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IS502_RS18915	COG1940	carbohydrate kinase activity
IS502_RS18915	COG1846	Transcriptional regulator
IS502_RS18920	COG0647	UMP catabolic process
IS502_RS18925	COG0367	asparagine synthase
IS502_RS18965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS502_RS18975	COG1702	phosphate starvation-inducible protein PhoH
IS502_RS18985	COG4535	Mg2 and Co2 transporter CorC
IS502_RS19000	COG0765	amino acid transport
IS502_RS19005	COG0765	amino acid transport
IS502_RS19010	COG1126	abc transporter atp-binding protein
IS502_RS19025	COG2888	peptidyl-tyrosine sulfation
IS502_RS19040	COG1466	dna polymerase III delta subunit
IS502_RS19055	COG0799	negative regulation of ribosome biogenesis
IS502_RS19065	COG0768	penicillin binding
IS502_RS19070	COG0772	Belongs to the SEDS family
IS502_RS19075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS502_RS19080	COG1686	Belongs to the peptidase S11 family
IS502_RS19095	COG0583	DNA-binding transcription factor activity
IS502_RS19110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS502_RS19130	COG3069	C4-dicarboxylate transmembrane transporter activity
IS502_RS19135	COG3719	Belongs to the RNase T2 family
IS502_RS19140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS502_RS19160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS502_RS19165	COG0583	DNA-binding transcription factor activity
IS502_RS19170	COG3969	phosphoadenosine phosphosulfate
IS502_RS19175	COG1475	DNA binding
IS502_RS19180	COG0436	Aminotransferase
IS502_RS19205	COG1129	ABC transporter
IS502_RS19210	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS19215	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS19225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS502_RS19240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS502_RS19250	COG0402	S-adenosylhomocysteine deaminase activity
IS502_RS19260	COG0483	inositol monophosphate 1-phosphatase activity
IS502_RS19265	COG2271	Major facilitator Superfamily
IS502_RS19295	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS19300	COG1129	ABC transporter
IS502_RS19305	COG0371	Dehydrogenase
IS502_RS19310	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS19325	COG2879	small protein
IS502_RS19330	COG1966	Carbon starvation protein
IS502_RS19340	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS19345	COG1535	isochorismatase
IS502_RS19345	COG3433	isochorismatase activity
IS502_RS19350	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS502_RS19355	COG1169	isochorismate synthase
IS502_RS19360	COG4592	Periplasmic binding protein
IS502_RS19370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS19375	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS19380	COG1120	ATPase activity
IS502_RS19385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS502_RS19385	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IS502_RS19390	COG3251	PFAM MbtH domain protein
IS502_RS19395	COG2382	esterase
IS502_RS19400	COG4771	TonB-dependent receptor
IS502_RS19405	COG2977	Belongs to the P-Pant transferase superfamily
IS502_RS19410	COG3958	Transketolase
IS502_RS19415	COG3959	Transketolase, thiamine diphosphate binding domain
IS502_RS19420	COG2390	Transcriptional regulator
IS502_RS19425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS502_RS19430	COG1879	ABC-type sugar transport system periplasmic component
IS502_RS19440	COG1129	ABC transporter
IS502_RS19445	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS19455	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS19465	COG0583	DNA-binding transcription factor activity
IS502_RS19470	COG0668	transmembrane transport
IS502_RS19480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS502_RS19505	COG0747	negative chemotaxis
IS502_RS19510	COG0601	transmembrane transport
IS502_RS19515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS502_RS19520	COG0444	Belongs to the ABC transporter superfamily
IS502_RS19525	COG4608	Belongs to the ABC transporter superfamily
IS502_RS19530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS502_RS19535	COG4221	oxidoreductase activity
IS502_RS19545	COG4215	(ABC) transporter
IS502_RS19550	COG0765	amino acid transport
IS502_RS19555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IS502_RS19570	COG0697	spore germination
IS502_RS19580	COG3698	Phosphodiester glycosidase
IS502_RS19625	COG2315	Protein conserved in bacteria
IS502_RS19630	COG0778	Nitroreductase
IS502_RS19640	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS19650	COG3716	PTS system mannose fructose sorbose family IID component
IS502_RS19655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS502_RS19660	COG2222	sugar isomerase
IS502_RS19665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS502_RS19665	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS502_RS19680	COG0477	Major facilitator Superfamily
IS502_RS19685	COG0668	transmembrane transport
IS502_RS19715	COG3188	usher protein
IS502_RS19730	COG2771	luxR family
IS502_RS19740	COG0673	inositol 2-dehydrogenase activity
IS502_RS19750	COG2211	Major facilitator Superfamily
IS502_RS19755	COG1113	amino acid transport
IS502_RS19770	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS19775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS502_RS19785	COG0531	amino acid
IS502_RS19830	COG0667	Aldo Keto reductase
IS502_RS19835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS19840	COG1473	amidohydrolase
IS502_RS19870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS19875	COG1120	ATPase activity
IS502_RS19880	COG1566	PFAM secretion protein HlyD family protein
IS502_RS19925	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS19930	COG1129	ABC transporter
IS502_RS19945	COG0673	inositol 2-dehydrogenase activity
IS502_RS19975	COG3104	oligopeptide transport
IS502_RS19980	COG1982	Orn Lys Arg decarboxylase major
IS502_RS19985	COG0531	amino acid
IS502_RS19990	COG3710	Transcriptional regulator
IS502_RS20000	COG1560	Kdo2-lipid A biosynthetic process
IS502_RS20015	COG3188	usher protein
IS502_RS20020	COG3121	Chaperone
IS502_RS20025	COG3539	Fimbrial protein
IS502_RS20075	COG2501	S4 domain
IS502_RS20085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS502_RS20100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IS502_RS20105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IS502_RS20125	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IS502_RS20130	COG4181	ATPase activity
IS502_RS20135	COG2755	lipolytic protein G-D-S-L family
IS502_RS20140	COG0300	oxidoreductase activity
IS502_RS20145	COG3118	belongs to the thioredoxin family
IS502_RS20150	COG0390	transport system, permease component
IS502_RS20155	COG4619	ABC transporter
IS502_RS20160	COG0330	HflC and HflK could
IS502_RS20165	COG1585	Membrane protein implicated in regulation of membrane protease activity
IS502_RS20180	COG3735	TraB family
IS502_RS20185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS502_RS20195	COG2223	nitrite transmembrane transporter activity
IS502_RS20200	COG4651	solute:proton antiporter activity
IS502_RS20200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS502_RS20205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS20245	COG2832	Protein of unknown function (DUF454)
IS502_RS20250	COG3923	Primosomal replication protein n
IS502_RS20260	COG5464	transposase or invertase
IS502_RS20265	COG1196	nuclear chromosome segregation
IS502_RS20265	COG3264	Mechanosensitive ion channel
IS502_RS20285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS20290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS502_RS20305	COG0110	maltose O-acetyltransferase activity
IS502_RS20355	COG1874	Beta-galactosidase
IS502_RS20360	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IS502_RS20365	COG3833	ABC-type maltose transport systems, permease component
IS502_RS20370	COG1175	transmembrane transport
IS502_RS20375	COG2182	Extracellular solute-binding protein
IS502_RS20385	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS502_RS20400	COG2364	Membrane
IS502_RS20430	COG3695	enzyme binding
IS502_RS20435	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IS502_RS20440	COG1946	Acyl-CoA thioesterase
IS502_RS20445	COG0004	ammonium transporteR
IS502_RS20450	COG0347	Belongs to the P(II) protein family
IS502_RS20455	COG1132	(ABC) transporter
IS502_RS20460	COG1132	(ABC) transporter
IS502_RS20465	COG1522	sequence-specific DNA binding
IS502_RS20480	COG4533	DNA binding
IS502_RS20490	COG0824	Thioesterase
IS502_RS20495	COG1555	photosystem II stabilization
IS502_RS20500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS502_RS20505	COG0776	regulation of translation
IS502_RS20510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IS502_RS20530	COG0271	Belongs to the BolA IbaG family
IS502_RS20535	COG3056	Lipoprotein
IS502_RS20540	COG2223	nitrite transmembrane transporter activity
IS502_RS20545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS502_RS20550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS502_RS20555	COG1845	cytochrome c oxidase, subunit III
IS502_RS20560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IS502_RS20575	COG1414	Transcriptional regulator
IS502_RS20580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS502_RS20585	COG1053	succinate dehydrogenase
IS502_RS20595	COG1053	succinate dehydrogenase
IS502_RS20610	COG0673	inositol 2-dehydrogenase activity
IS502_RS20615	COG2814	Major facilitator Superfamily
IS502_RS20625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IS502_RS20630	COG0693	protein deglycase activity
IS502_RS20650	COG0142	geranyltranstransferase activity
IS502_RS20660	COG0667	Aldo Keto reductase
IS502_RS20665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IS502_RS20685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS502_RS20685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS502_RS20695	COG4238	major outer membrane lipoprotein
IS502_RS20715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS502_RS20720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS502_RS20725	COG1862	Preprotein translocase
IS502_RS20750	COG0450	alkyl hydroperoxide reductase
IS502_RS20760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS20775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS20785	COG1228	amidohydrolase
IS502_RS20795	COG1335	isochorismatase
IS502_RS20800	COG0583	DNA-binding transcription factor activity
IS502_RS20805	COG0366	Alpha amylase catalytic
IS502_RS20830	COG0420	3'-5' exonuclease activity
IS502_RS20835	COG0419	ATPase involved in DNA repair
IS502_RS20840	COG1940	carbohydrate kinase activity
IS502_RS20855	COG4126	flavin adenine dinucleotide binding
IS502_RS20865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS502_RS20870	COG3416	Protein conserved in bacteria
IS502_RS20880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IS502_RS20890	COG1785	Belongs to the alkaline phosphatase family
IS502_RS20930	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IS502_RS20935	COG1335	isochorismatase
IS502_RS20940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IS502_RS20945	COG0113	porphobilinogen synthase activity
IS502_RS20955	COG2175	clavaminate synthase activity
IS502_RS20960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS502_RS20965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IS502_RS20970	COG4521	taurine ABC transporter
IS502_RS20975	COG2040	homocysteine
IS502_RS20980	COG0833	amino acid
IS502_RS20995	COG4303	Ethanolamine ammonia lyase large subunit
IS502_RS21000	COG4302	ethanolamine ammonia-lyase activity
IS502_RS21040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS21045	COG1126	abc transporter atp-binding protein
IS502_RS21050	COG0765	amino acid transport
IS502_RS21055	COG0765	amino acid transport
IS502_RS21070	COG3188	usher protein
IS502_RS21095	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IS502_RS21105	COG3639	organic phosphonate transmembrane transporter activity
IS502_RS21125	COG0791	NLP P60 protein
IS502_RS21150	COG0582	viral genome integration into host DNA
IS502_RS21155	COG1192	Involved in chromosome partitioning
IS502_RS21215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IS502_RS21220	COG0022	dehydrogenase e1 component
IS502_RS21225	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS502_RS21230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS502_RS21250	COG1070	Carbohydrate kinase
IS502_RS21255	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS21260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS502_RS21265	COG3775	system Galactitol-specific IIC component
IS502_RS21270	COG0625	glutathione transferase activity
IS502_RS21275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IS502_RS21290	COG0579	oxidoreductase
IS502_RS21295	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS21300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS502_RS21305	COG1113	amino acid transport
IS502_RS21310	COG1802	Transcriptional regulator
IS502_RS21330	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS502_RS21335	COG0454	-acetyltransferase
IS502_RS21350	COG2991	Protein conserved in bacteria
IS502_RS21365	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS502_RS21370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS502_RS21385	COG3034	peptidoglycan biosynthetic process
IS502_RS21390	COG0121	glutamine amidotransferase
IS502_RS21400	COG1960	acyl-CoA dehydrogenase activity
IS502_RS21405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS502_RS21415	COG0583	DNA-binding transcription factor activity
IS502_RS21425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS502_RS21435	COG2226	methyltransferase
IS502_RS21445	COG1388	LysM domain
IS502_RS21445	COG0741	lytic transglycosylase activity
IS502_RS21450	COG2226	methyltransferase
IS502_RS21460	COG2814	Major facilitator Superfamily
IS502_RS21465	COG0583	DNA-binding transcription factor activity
IS502_RS21470	COG0656	L-ascorbic acid biosynthetic process
IS502_RS21505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS502_RS21515	COG2011	ABC-type metal ion transport system permease component
IS502_RS21520	COG1464	Belongs to the NlpA lipoprotein family
IS502_RS21530	COG1720	tRNA m6t6A37 methyltransferase activity
IS502_RS21540	COG0791	NLP P60 protein
IS502_RS21545	COG3015	lipoprotein NlpE involved in copper resistance
IS502_RS21550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IS502_RS21565	COG4568	rho-dependent transcription termination
IS502_RS21575	COG0346	lactoylglutathione lyase activity
IS502_RS21580	COG1982	Orn Lys Arg decarboxylase major
IS502_RS21620	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IS502_RS21630	COG0750	zinc metalloprotease
IS502_RS21635	COG0575	Belongs to the CDS family
IS502_RS21645	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IS502_RS21670	COG0024	Methionine aminopeptidase
IS502_RS21675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IS502_RS21690	COG3835	regulator
IS502_RS21695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS502_RS21715	COG2860	membrane
IS502_RS21735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS21740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS502_RS21745	COG1120	ATPase activity
IS502_RS21755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS502_RS21850	COG1643	Atp-dependent helicase
IS502_RS21855	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IS502_RS21875	COG0617	tRNA 3'-terminal CCA addition
IS502_RS21880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS502_RS21900	COG0726	polysaccharide deacetylase
IS502_RS21905	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS21910	COG0842	Transport permease protein
IS502_RS21915	COG1131	(ABC) transporter
IS502_RS21920	COG0288	reversible hydration of carbon dioxide
IS502_RS21935	COG4993	Dehydrogenase
IS502_RS21940	COG2132	Multicopper oxidase
IS502_RS21990	COG3064	Membrane
IS502_RS22005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS502_RS22010	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS502_RS22015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IS502_RS22020	COG2186	Transcriptional regulator
IS502_RS22025	COG1113	amino acid transport
IS502_RS22030	COG2211	Major facilitator Superfamily
IS502_RS22035	COG3940	Belongs to the glycosyl hydrolase 43 family
IS502_RS22040	COG3725	Membrane protein required for beta-lactamase induction
IS502_RS22045	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS502_RS22055	COG4969	Belongs to the N-Me-Phe pilin family
IS502_RS22060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS502_RS22065	COG1459	type II secretion system
IS502_RS22090	COG0494	nUDIX hydrolase
IS502_RS22110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IS502_RS22115	COG0849	cell division
IS502_RS22140	COG0772	Belongs to the SEDS family
IS502_RS22155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IS502_RS22160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IS502_RS22165	COG0768	penicillin binding
IS502_RS22185	COG1609	Transcriptional regulator
IS502_RS22195	COG0028	Belongs to the TPP enzyme family
IS502_RS22240	COG0738	Major facilitator superfamily
IS502_RS22250	COG0583	DNA-binding transcription factor activity
IS502_RS22255	COG2271	Major facilitator Superfamily
IS502_RS22260	COG2814	Major facilitator Superfamily
IS502_RS22280	COG1178	ABC-type Fe3 transport system permease component
IS502_RS22290	COG0586	Pfam SNARE associated Golgi protein
IS502_RS22310	COG0235	Class ii aldolase
IS502_RS22315	COG0417	DNA replication proofreading
IS502_RS22325	COG0564	pseudouridine synthase activity
IS502_RS22335	COG3493	citrate carrier protein
IS502_RS22350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS502_RS22355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IS502_RS22365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS502_RS22410	COG0505	Belongs to the CarA family
IS502_RS22475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IS502_RS22500	COG1047	Peptidyl-prolyl cis-trans
IS502_RS22515	COG0196	riboflavin kinase activity
IS502_RS22525	COG0583	DNA-binding transcription factor activity
IS502_RS22550	COG4735	regulation of single-species biofilm formation
IS502_RS22555	COG1584	GPR1 FUN34 yaaH family protein
IS502_RS22560	COG0477	Major facilitator Superfamily
IS502_RS22565	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS502_RS22570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS502_RS22575	COG1115	amino acid carrier protein
IS502_RS22590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IS502_RS22600	COG0460	homoserine dehydrogenase
IS502_RS22600	COG0527	aspartate kinase activity
IS502_RS22610	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IS502_RS22620	COG0745	RESPONSE REGULATOR receiver
IS502_RS22625	COG4452	Inner membrane protein CreD
IS502_RS22630	COG2205	protein histidine kinase activity
IS502_RS22635	COG0745	RESPONSE REGULATOR receiver
IS502_RS22640	COG3045	CreA protein
IS502_RS22645	COG2207	Transcriptional regulator
IS502_RS22645	COG3708	Transcriptional regulator
IS502_RS22665	COG0741	lytic transglycosylase activity
IS502_RS22670	COG0488	(ABC) transporter
IS502_RS22680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IS502_RS22685	COG0560	Phosphoserine phosphatase
IS502_RS22690	COG3726	membrane protein affecting hemolysin expression
IS502_RS22720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS502_RS22725	COG0084	hydrolase, TatD family'
IS502_RS22730	COG4667	esterase of the alpha-beta hydrolase superfamily
IS502_RS22740	COG2823	Periplasmic or secreted lipoprotein
IS502_RS22750	COG1011	Hydrolase
IS502_RS22755	COG0456	acetyltransferase
IS502_RS22760	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IS502_RS22795	COG3706	GGDEF domain
IS502_RS22800	COG4114	ferric iron reductase
IS502_RS22805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS22805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS22810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS502_RS22815	COG2197	response regulator
IS502_RS22820	COG2197	response regulator
IS502_RS22835	COG2966	Psort location CytoplasmicMembrane, score
IS502_RS22850	COG1484	DNA-dependent DNA replication
IS502_RS22865	COG5464	transposase or invertase
IS502_RS22875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS502_RS22880	COG3716	PTS system mannose fructose sorbose family IID component
IS502_RS22885	COG3715	PTS system
IS502_RS22900	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS502_RS22900	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS502_RS22910	COG1063	alcohol dehydrogenase
IS502_RS22915	COG1802	Transcriptional regulator
IS502_RS22920	COG2271	Major facilitator Superfamily
IS502_RS22925	COG1214	PFAM Peptidase M22, glycoprotease
IS502_RS22925	COG0456	acetyltransferase
IS502_RS22935	COG1737	Transcriptional regulator
IS502_RS22940	COG0800	Aldolase
IS502_RS22945	COG3734	2-keto-3-deoxy-galactonokinase
IS502_RS22960	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IS502_RS22990	COG1846	Transcriptional regulator
IS502_RS23000	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS502_RS23010	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS23015	COG3384	dioxygenase
IS502_RS23025	COG3971	2-oxopent-4-enoate hydratase activity
IS502_RS23045	COG2368	4-hydroxyphenylacetate
IS502_RS23050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS502_RS23065	COG1966	Carbon starvation protein
IS502_RS23070	COG2879	small protein
IS502_RS23075	COG0523	cobalamin synthesis protein
IS502_RS23085	COG1012	belongs to the aldehyde dehydrogenase family
IS502_RS23090	COG5464	transposase or invertase
IS502_RS23095	COG1917	Cupin 2, conserved barrel domain protein
IS502_RS23095	COG2207	Transcriptional regulator
IS502_RS23105	COG2733	membrane
IS502_RS23120	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IS502_RS23125	COG1924	4 iron, 4 sulfur cluster binding
IS502_RS23140	COG1566	PFAM secretion protein HlyD family protein
IS502_RS23150	COG5457	Domain of unknown function (DUF1127)
IS502_RS23155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS502_RS23165	COG0583	DNA-binding transcription factor activity
IS502_RS23170	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS502_RS23180	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS23185	COG1129	ABC transporter
IS502_RS23190	COG1879	ABC-type sugar transport system periplasmic component
IS502_RS23200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS23205	COG1129	ABC transporter
IS502_RS23205	COG0842	Transport permease protein
IS502_RS23210	COG0842	Transport permease protein
IS502_RS23240	COG2850	peptidyl-arginine hydroxylation
IS502_RS23255	COG5002	protein histidine kinase activity
IS502_RS23260	COG0745	RESPONSE REGULATOR receiver
IS502_RS23265	COG1538	Outer membrane efflux protein
IS502_RS23270	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS23275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS23280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS502_RS23290	COG3040	lipid binding
IS502_RS23295	COG0789	Transcriptional regulator
IS502_RS23305	COG0300	oxidoreductase activity
IS502_RS23320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS502_RS23340	COG3272	Protein of unknown function (DUF1722)
IS502_RS23345	COG4580	involved in the transport of maltose and maltodextrins
IS502_RS23355	COG2211	Major facilitator Superfamily
IS502_RS23360	COG3507	Belongs to the glycosyl hydrolase 43 family
IS502_RS23455	COG3039	Transposase
IS502_RS23465	COG0582	viral genome integration into host DNA
IS502_RS23475	COG0288	reversible hydration of carbon dioxide
IS502_RS23480	COG0659	secondary active sulfate transmembrane transporter activity
IS502_RS23485	COG1064	alcohol dehydrogenase
IS502_RS23490	COG1175	transmembrane transport
IS502_RS23495	COG0395	ABC-type sugar transport system, permease component
IS502_RS23500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS502_RS23505	COG3842	ATPase activity
IS502_RS23510	COG1653	transport
IS502_RS23520	COG1082	Xylose isomerase domain protein TIM barrel
IS502_RS23530	COG3962	Belongs to the TPP enzyme family
IS502_RS23535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS23540	COG1737	Transcriptional regulator
IS502_RS23540	COG0837	glucose binding
IS502_RS23545	COG3718	enzyme involved in inositol metabolism
IS502_RS23560	COG0433	COG0433 Predicted ATPase
IS502_RS23565	COG0795	lipopolysaccharide-transporting ATPase activity
IS502_RS23570	COG0795	lipopolysaccharide-transporting ATPase activity
IS502_RS23580	COG2927	DNA polymerase III (CHI subunit)
IS502_RS23585	COG0525	valine-tRNA ligase activity
IS502_RS23610	COG2188	Transcriptional regulator
IS502_RS23615	COG1288	antiporter activity
IS502_RS23620	COG1228	amidohydrolase
IS502_RS23625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS23630	COG2222	sugar isomerase
IS502_RS23635	COG2731	YhcH YjgK YiaL family protein
IS502_RS23670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS502_RS23670	COG1263	PTS System
IS502_RS23675	COG0366	Alpha amylase catalytic
IS502_RS23680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS502_RS23685	COG1486	melibiose metabolic process
IS502_RS23710	COG0602	queuosine metabolic process
IS502_RS23715	COG2026	Addiction module toxin, RelE StbE family
IS502_RS23720	COG3077	Addiction module antitoxin, RelB DinJ family
IS502_RS23725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS502_RS23725	COG3711	transcriptional antiterminator
IS502_RS23730	COG2706	6-phosphogluconolactonase activity
IS502_RS23745	COG3964	amidohydrolase
IS502_RS23785	COG0312	modulator of DNA gyrase
IS502_RS23810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS502_RS23820	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS23825	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS23830	COG1129	ABC transporter
IS502_RS23835	COG1879	ABC-type sugar transport system periplasmic component
IS502_RS23855	COG2105	PFAM AIG2 family protein
IS502_RS23860	COG2911	Protein conserved in bacteria
IS502_RS23865	COG0729	surface antigen
IS502_RS23875	COG1253	flavin adenine dinucleotide binding
IS502_RS23890	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IS502_RS23905	COG1733	regulation of RNA biosynthetic process
IS502_RS23910	COG0702	epimerase
IS502_RS23920	COG0697	spore germination
IS502_RS23930	COG1113	amino acid transport
IS502_RS23935	COG0545	Peptidyl-prolyl cis-trans isomerase
IS502_RS23940	COG3061	Opacity-associated protein A
IS502_RS23950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IS502_RS23955	COG2965	DNA replication, synthesis of RNA primer
IS502_RS24015	COG1073	alpha beta
IS502_RS24020	COG3650	response to hydrogen peroxide
IS502_RS24030	COG1960	acyl-CoA dehydrogenase activity
IS502_RS24035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS502_RS24040	COG0557	exoribonuclease II activity
IS502_RS24055	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IS502_RS24065	COG0330	HflC and HflK could
IS502_RS24070	COG0330	HflC and HflK could
IS502_RS24075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS502_RS24095	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS502_RS24100	COG0802	atpase or kinase
IS502_RS24105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IS502_RS24105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IS502_RS24110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS502_RS24130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS502_RS24150	COG1511	domain protein
IS502_RS24150	COG3264	Mechanosensitive ion channel
IS502_RS24165	COG1053	succinate dehydrogenase
IS502_RS24170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS502_RS24190	COG2076	Multidrug Resistance protein
IS502_RS24195	COG5510	response to toxic substance
IS502_RS24210	COG1509	lysine 2,3-aminomutase activity
IS502_RS24280	COG0531	amino acid
IS502_RS24285	COG3030	protein affecting phage T7 exclusion by the F plasmid
IS502_RS24290	COG1027	Aspartate ammonia-lyase
IS502_RS24295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS502_RS24310	COG1309	transcriptional regulator
IS502_RS24340	COG0457	Tetratricopeptide repeat
IS502_RS24345	COG1649	PFAM Uncharacterised BCR, COG1649
IS502_RS24345	COG0726	polysaccharide deacetylase
IS502_RS24350	COG1215	transferase activity, transferring glycosyl groups
IS502_RS24365	COG0861	Integral membrane protein TerC family
IS502_RS24410	COG1486	melibiose metabolic process
IS502_RS24415	COG2169	Transcriptional regulator
IS502_RS24425	COG2824	Alkylphosphonate utilization operon protein PhnA
IS502_RS24430	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IS502_RS24435	COG2188	Transcriptional regulator
IS502_RS24440	COG3624	Phosphonate C-P lyase system protein PhnG
IS502_RS24445	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IS502_RS24450	COG3626	phosphonate metabolism
IS502_RS24455	COG3627	carbon phosphorus lyase activity
IS502_RS24460	COG4107	phosphonate C-P lyase system protein PhnK
IS502_RS24465	COG4778	phosphonate C-P lyase system protein PhnL
IS502_RS24470	COG3454	Phosphonate metabolism
IS502_RS24480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IS502_RS24490	COG0784	Response regulator, receiver
IS502_RS24490	COG4191	Histidine kinase
IS502_RS24495	COG1129	ABC transporter
IS502_RS24500	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS24535	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IS502_RS24540	COG1301	dicarboxylic acid transport
IS502_RS24550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS502_RS24555	COG3162	membrane
IS502_RS24585	COG3539	Fimbrial protein
IS502_RS24590	COG1346	cytolysis
IS502_RS24595	COG1380	Effector of murein hydrolase LrgA
IS502_RS24600	COG0583	DNA-binding transcription factor activity
IS502_RS24605	COG0025	NhaP-type Na H and K H
IS502_RS24610	COG2252	PERMEase
IS502_RS24615	COG0625	glutathione transferase activity
IS502_RS24620	COG0789	Transcriptional regulator
IS502_RS24630	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS502_RS24660	COG1234	tRNA 3'-trailer cleavage
IS502_RS24665	COG1609	Transcriptional regulator
IS502_RS24670	COG0483	inositol monophosphate 1-phosphatase activity
IS502_RS24680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS502_RS24700	COG4771	TonB-dependent receptor
IS502_RS24705	COG0741	lytic transglycosylase activity
IS502_RS24720	COG2315	Protein conserved in bacteria
IS502_RS24725	COG0432	Pfam Uncharacterised protein family UPF0047
IS502_RS24740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IS502_RS24745	COG0305	Participates in initiation and elongation during chromosome replication
IS502_RS24760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS502_RS24770	COG0735	belongs to the Fur family
IS502_RS24775	COG3237	CsbD-like
IS502_RS24785	COG0534	Mate efflux family protein
IS502_RS24795	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IS502_RS24865	COG0251	oxidation-reduction process
IS502_RS24875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IS502_RS24885	COG0527	aspartate kinase activity
IS502_RS24940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS502_RS24970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IS502_RS24980	COG0456	acetyltransferase
IS502_RS25010	COG0151	Belongs to the GarS family
IS502_RS25020	COG4191	Histidine kinase
IS502_RS25025	COG3678	ATP-independent chaperone mediated protein folding
IS502_RS25060	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IS502_RS25075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS502_RS25080	COG2104	thiamine diphosphate biosynthetic process
IS502_RS25095	COG3706	GGDEF domain
IS502_RS25105	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS502_RS25110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS502_RS25145	COG0250	Participates in transcription elongation, termination and antitermination
IS502_RS25190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IS502_RS25215	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IS502_RS25225	COG1739	Uncharacterized protein family UPF0029
IS502_RS25265	COG0805	protein transport
IS502_RS25285	COG3165	ubiquinone biosynthetic process from chorismate
IS502_RS25315	COG0583	DNA-binding transcription factor activity
IS502_RS25320	COG0697	spore germination
IS502_RS25325	COG0561	phosphatase activity
IS502_RS25330	COG2267	carboxylic ester hydrolase activity
IS502_RS25335	COG1280	lysine exporter protein (LysE YggA)
IS502_RS25345	COG1280	lysine exporter protein (LysE YggA)
IS502_RS25375	COG0210	DNA helicase
IS502_RS25380	COG1011	Hydrolase
IS502_RS25410	COG3072	Adenylate cyclase
IS502_RS25425	COG2959	enzyme of heme biosynthesis
IS502_RS25430	COG3071	HemY protein
IS502_RS25475	COG2244	polysaccharide biosynthetic process
IS502_RS25480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IS502_RS25485	COG0456	acetyltransferase
IS502_RS25490	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IS502_RS25495	COG1088	dTDP-glucose 4,6-dehydratase activity
IS502_RS25500	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IS502_RS25505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IS502_RS25515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS502_RS25520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IS502_RS25525	COG3118	belongs to the thioredoxin family
IS502_RS25550	COG1811	Na channel or pump
IS502_RS25560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS502_RS25565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS502_RS25575	COG0583	DNA-binding transcription factor activity
IS502_RS25580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS502_RS25595	COG3978	acetolactate synthase activity
IS502_RS25615	COG3085	chromosome segregation
IS502_RS25690	COG0583	DNA-binding transcription factor activity
IS502_RS25705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IS502_RS25720	COG3443	Belongs to the bacterial solute-binding protein 9 family
IS502_RS25725	COG2207	Transcriptional regulator
IS502_RS25735	COG0371	Dehydrogenase
IS502_RS25740	COG0697	spore germination
IS502_RS25750	COG0583	DNA-binding transcription factor activity
IS502_RS25760	COG0737	Belongs to the 5'-nucleotidase family
IS502_RS25770	COG0527	aspartate kinase activity
IS502_RS25770	COG0460	homoserine dehydrogenase
IS502_RS25775	COG0626	cystathionine gamma-synthase activity
IS502_RS25790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IS502_RS25795	COG1609	Transcriptional regulator
IS502_RS25800	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS502_RS25815	COG1575	Belongs to the MenA family. Type 1 subfamily
IS502_RS25835	COG3678	ATP-independent chaperone mediated protein folding
IS502_RS25840	COG0745	RESPONSE REGULATOR receiver
IS502_RS25845	COG2205	protein histidine kinase activity
IS502_RS25850	COG2258	MOSC domain
IS502_RS25855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IS502_RS25895	COG1129	ABC transporter
IS502_RS25900	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS25905	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS25910	COG1454	alcohol dehydrogenase
IS502_RS25920	COG2211	Major facilitator Superfamily
IS502_RS25980	COG0205	6-phosphofructokinase activity
IS502_RS26000	COG0437	4 iron, 4 sulfur cluster binding
IS502_RS26005	COG2864	formate dehydrogenase
IS502_RS26020	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IS502_RS26025	COG0657	acetylesterase activity
IS502_RS26030	COG0456	acetyltransferase
IS502_RS26045	COG1011	Hydrolase
IS502_RS26060	COG3852	Histidine kinase
IS502_RS26075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS502_RS26095	COG0204	Acyl-transferase
IS502_RS26105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IS502_RS26110	COG3084	Protein conserved in bacteria
IS502_RS26120	COG1763	Mo-molybdopterin cofactor biosynthetic process
IS502_RS26145	COG2186	Transcriptional regulator
IS502_RS26150	COG0477	Major facilitator Superfamily
IS502_RS26155	COG1609	Transcriptional regulator
IS502_RS26160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS502_RS26170	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS502_RS26175	COG1129	ABC transporter
IS502_RS26205	COG1522	sequence-specific DNA binding
IS502_RS26210	COG0716	FMN binding
IS502_RS26225	COG3312	ion transport
IS502_RS26275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS502_RS26280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS502_RS26285	COG0573	inorganic phosphate transmembrane transporter activity
IS502_RS26290	COG0581	inorganic phosphate transmembrane transporter activity
IS502_RS26295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS502_RS26300	COG0704	Plays a role in the regulation of phosphate uptake
IS502_RS26310	COG2382	esterase
IS502_RS26315	COG0363	glucosamine-6-phosphate deaminase activity
IS502_RS26320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS502_RS26325	COG2252	PERMEase
IS502_RS26330	COG0431	NADPH-dependent FMN reductase
IS502_RS26335	COG2091	lysine biosynthetic process via aminoadipic acid
IS502_RS26365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IS502_RS26385	COG3436	PFAM IS66 Orf2 family protein
IS502_RS26390	COG4372	Transposase
IS502_RS26480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS502_RS26505	COG2144	transferase activity, transferring acyl groups
IS502_RS26550	COG3436	PFAM IS66 Orf2 family protein
IS502_RS26555	COG4372	Transposase
IS502_RS26575	COG4245	von Willebrand factor, type A
IS502_RS26580	COG4245	von Willebrand factor, type A
IS502_RS26590	COG4245	von Willebrand factor, type A
IS502_RS26610	COG1358	cellular component organization or biogenesis
IS502_RS26700	COG1028	Short-chain dehydrogenase reductase Sdr
IS502_RS26700	COG0604	alcohol dehydrogenase
IS502_RS26700	COG3321	synthase
IS502_RS26715	COG1522	sequence-specific DNA binding
IS502_RS26905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS502_RS26915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IS502_RS26950	COG0500	methyltransferase
IS502_RS27005	COG5642	Protein of unknown function (DUF2384)
IS502_RS27010	COG5654	RES domain protein
IS502_RS27030	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS502_RS27040	COG0656	L-ascorbic acid biosynthetic process
IS502_RS27065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS502_RS27110	COG0735	belongs to the Fur family
IS502_RS27115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IS502_RS27120	COG0523	cobalamin synthesis protein
IS502_RS27185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IS502_RS27250	COG4680	protein conserved in bacteria
IS502_RS27255	COG5499	transcription regulator containing HTH domain
IS502_RS27310	COG0789	Transcriptional regulator
IS502_RS27325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IS502_RS27340	COG2205	protein histidine kinase activity
IS502_RS27345	COG0745	RESPONSE REGULATOR receiver
IS502_RS27350	COG1276	copper resistance
IS502_RS27355	COG2372	response to copper ion
IS502_RS27360	COG3667	copper resistance
IS502_RS27365	COG2132	Multicopper oxidase
IS502_RS27375	COG0739	heme binding
IS502_RS27405	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS502_RS27740	COG3436	PFAM IS66 Orf2 family protein
IS502_RS27745	COG4372	Transposase
IS502_RS27845	COG3344	reverse transcriptase
IS502_RS27925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IS502_RS28075	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IS502_RS28240	COG1349	DNA-binding transcription factor activity
IS502_RS28245	COG2084	Dehydrogenase
IS502_RS28380	COG3344	reverse transcriptase
IS502_RS28555	COG4372	Transposase
IS502_RS28560	COG3436	PFAM IS66 Orf2 family protein
IS502_RS28635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS502_RS28655	COG3344	reverse transcriptase
IS502_RS28780	COG0697	spore germination
IS502_RS28795	COG0768	penicillin binding
IS502_RS28905	COG2003	Belongs to the UPF0758 family
IS502_RS28985	COG2198	Histidine kinase
IS502_RS28985	COG5002	protein histidine kinase activity
IS502_RS28985	COG0784	Response regulator, receiver
IS502_RS29010	COG0741	lytic transglycosylase activity
IS502_RS29060	COG3064	Membrane
IS502_RS29120	COG3344	reverse transcriptase