locus-tag	class	description
IS499_RS00020	COG0187	DNA topoisomerase II activity
IS499_RS00025	COG0561	phosphatase activity
IS499_RS00040	COG2186	Transcriptional regulator
IS499_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
IS499_RS00050	COG0800	Aldolase
IS499_RS00070	COG2271	Major facilitator Superfamily
IS499_RS00075	COG0823	Involved in the tonB-independent uptake of proteins
IS499_RS00080	COG5645	(Lipo)protein
IS499_RS00095	COG3645	SOS response
IS499_RS00105	COG2188	Transcriptional regulator
IS499_RS00120	COG2149	membrane
IS499_RS00140	COG2610	gluconate transmembrane transporter activity
IS499_RS00150	COG0583	DNA-binding transcription factor activity
IS499_RS00155	COG2814	Major facilitator Superfamily
IS499_RS00185	COG0028	Belongs to the TPP enzyme family
IS499_RS00190	COG0440	acetolactate synthase activity
IS499_RS00195	COG2197	response regulator
IS499_RS00205	COG2271	Major facilitator Superfamily
IS499_RS00245	COG2188	Transcriptional regulator
IS499_RS00270	COG4580	involved in the transport of maltose and maltodextrins
IS499_RS00275	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS499_RS00280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS00280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS00290	COG1609	Transcriptional regulator
IS499_RS00300	COG3384	dioxygenase
IS499_RS00305	COG0583	DNA-binding transcription factor activity
IS499_RS00310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IS499_RS00315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS499_RS00320	COG2828	Protein conserved in bacteria
IS499_RS00335	COG0697	spore germination
IS499_RS00340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS00340	COG1263	PTS System
IS499_RS00350	COG2814	Major facilitator Superfamily
IS499_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS499_RS00395	COG0583	DNA-binding transcription factor activity
IS499_RS00420	COG1464	Belongs to the NlpA lipoprotein family
IS499_RS00435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IS499_RS00445	COG1064	alcohol dehydrogenase
IS499_RS00475	COG2211	Major facilitator Superfamily
IS499_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
IS499_RS00490	COG1486	melibiose metabolic process
IS499_RS00495	COG1263	PTS System
IS499_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS00500	COG2982	Protein involved in outer membrane biogenesis
IS499_RS00505	COG2233	PERMEase
IS499_RS00510	COG0786	glutamate:sodium symporter activity
IS499_RS00530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IS499_RS00555	COG3152	Membrane
IS499_RS00565	COG1494	fructose-1,6-bisphosphatase
IS499_RS00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IS499_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS499_RS00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS499_RS00600	COG2860	membrane
IS499_RS00610	COG2169	Transcriptional regulator
IS499_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS499_RS00615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IS499_RS00620	COG1561	YicC-like family, N-terminal region
IS499_RS00625	COG3039	Transposase
IS499_RS00645	COG1131	(ABC) transporter
IS499_RS00650	COG0842	Transport permease protein
IS499_RS00675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IS499_RS00710	COG1519	Transferase
IS499_RS00715	COG1216	Glycosyl transferase, family 2
IS499_RS00720	COG0438	transferase activity, transferring glycosyl groups
IS499_RS00730	COG0859	PFAM glycosyl transferase family 9
IS499_RS00755	COG0859	PFAM glycosyl transferase family 9
IS499_RS00770	COG0156	8-amino-7-oxononanoate synthase activity
IS499_RS00780	COG0463	Glycosyl transferase, family 2
IS499_RS00785	COG2861	carbohydrate metabolic process
IS499_RS00790	COG4942	peptidase
IS499_RS00800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS499_RS00805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS499_RS00825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IS499_RS00835	COG2186	Transcriptional regulator
IS499_RS00855	COG3722	fumarate hydratase activity
IS499_RS00875	COG1566	PFAM secretion protein HlyD family protein
IS499_RS00880	COG0625	glutathione transferase activity
IS499_RS00890	COG3276	selenocysteine insertion sequence binding
IS499_RS00895	COG1414	Transcriptional regulator
IS499_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS499_RS00905	COG3977	Valine--pyruvate aminotransferase
IS499_RS00910	COG0366	Alpha amylase catalytic
IS499_RS00915	COG2992	FlgJ-related protein
IS499_RS00920	COG1609	Transcriptional regulator
IS499_RS00920	COG2207	Transcriptional regulator
IS499_RS00925	COG4214	carbohydrate transport
IS499_RS00935	COG4213	ABC transporter substrate-binding protein
IS499_RS00950	COG4682	membrane
IS499_RS00955	COG4682	membrane
IS499_RS00960	COG3274	enterobacterial common antigen metabolic process
IS499_RS00985	COG3039	Transposase
IS499_RS01000	COG1278	Cold shock
IS499_RS01005	COG2944	sequence-specific DNA binding
IS499_RS01010	COG2814	Major facilitator Superfamily
IS499_RS01030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS01040	COG1609	Transcriptional regulator
IS499_RS01045	COG2885	chlorophyll binding
IS499_RS01050	COG0243	molybdopterin cofactor binding
IS499_RS01055	COG0456	acetyltransferase
IS499_RS01060	COG2818	Glycosylase
IS499_RS01065	COG5571	outer membrane autotransporter
IS499_RS01070	COG2223	nitrite transmembrane transporter activity
IS499_RS01100	COG0747	negative chemotaxis
IS499_RS01105	COG0601	transmembrane transport
IS499_RS01110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS499_RS01115	COG0444	Belongs to the ABC transporter superfamily
IS499_RS01120	COG4608	Belongs to the ABC transporter superfamily
IS499_RS01145	COG1215	transferase activity, transferring glycosyl groups
IS499_RS01150	COG0457	Tetratricopeptide repeat
IS499_RS01165	COG2194	sulfuric ester hydrolase activity
IS499_RS01195	COG1215	transferase activity, transferring glycosyl groups
IS499_RS01200	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IS499_RS01205	COG0457	Tetratricopeptide repeat
IS499_RS01205	COG3118	belongs to the thioredoxin family
IS499_RS01210	COG2200	EAL domain
IS499_RS01210	COG2199	diguanylate cyclase activity
IS499_RS01220	COG0612	Peptidase, M16
IS499_RS01230	COG2982	Protein involved in outer membrane biogenesis
IS499_RS01235	COG0477	Major facilitator Superfamily
IS499_RS01240	COG1295	ribonuclease BN
IS499_RS01245	COG0583	DNA-binding transcription factor activity
IS499_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS499_RS01265	COG1454	alcohol dehydrogenase
IS499_RS01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS499_RS01280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IS499_RS01285	COG0671	phosphoesterase, PA-phosphatase related
IS499_RS01305	COG0589	response to stress
IS499_RS01315	COG0306	phosphate transporter
IS499_RS01320	COG2081	HI0933 family
IS499_RS01325	COG2239	Acts as a magnesium transporter
IS499_RS01335	COG1124	(ABC) transporter
IS499_RS01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS499_RS01350	COG0601	transmembrane transport
IS499_RS01355	COG0747	negative chemotaxis
IS499_RS01365	COG3479	Phenolic acid decarboxylase
IS499_RS01405	COG0628	permease
IS499_RS01410	COG0477	Major facilitator Superfamily
IS499_RS01420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS499_RS01435	COG3714	YhhN family
IS499_RS01445	COG3776	membrane
IS499_RS01450	COG0742	ribosomal rna small subunit methyltransferase
IS499_RS01455	COG0552	protein localization to endoplasmic reticulum
IS499_RS01460	COG2884	Cell division ATP-binding protein ftsE
IS499_RS01465	COG2177	Part of the ABC transporter FtsEX involved in
IS499_RS01480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS499_RS01490	COG0683	leucine binding
IS499_RS01500	COG0683	leucine binding
IS499_RS01505	COG0559	Belongs to the binding-protein-dependent transport system permease family
IS499_RS01555	COG0584	glycerophosphoryl diester phosphodiesterase
IS499_RS01565	COG0405	Gamma-glutamyltransferase
IS499_RS01570	COG1247	-acetyltransferase
IS499_RS01580	COG0673	inositol 2-dehydrogenase activity
IS499_RS01585	COG1741	Belongs to the pirin family
IS499_RS01590	COG1609	Transcriptional regulator
IS499_RS01595	COG3265	gluconokinase activity
IS499_RS01600	COG2610	gluconate transmembrane transporter activity
IS499_RS01610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS499_RS01635	COG0058	SHG alpha-glucan phosphorylase activity
IS499_RS01650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS499_RS01665	COG1349	DNA-binding transcription factor activity
IS499_RS01680	COG0058	SHG alpha-glucan phosphorylase activity
IS499_RS01685	COG1640	4-alpha-glucanotransferase
IS499_RS01690	COG2610	gluconate transmembrane transporter activity
IS499_RS01700	COG1040	competence protein
IS499_RS01725	COG1918	ferrous iron import across plasma membrane
IS499_RS01730	COG2183	response to ionizing radiation
IS499_RS01735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS499_RS01760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IS499_RS01765	COG1011	Hydrolase
IS499_RS01775	COG0494	nUDIX hydrolase
IS499_RS01780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IS499_RS01805	COG4796	Type ii and iii secretion system protein
IS499_RS01820	COG3266	domain, Protein
IS499_RS01825	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IS499_RS01830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS499_RS01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS499_RS01860	COG0402	S-adenosylhomocysteine deaminase activity
IS499_RS01865	COG0738	Major facilitator superfamily
IS499_RS01890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS499_RS01895	COG1289	transmembrane transporter activity
IS499_RS01905	COG1765	OsmC-like protein
IS499_RS01910	COG3954	Phosphoribulokinase
IS499_RS01920	COG0429	hydrolase of the alpha beta-hydrolase fold
IS499_RS01925	COG0488	(ABC) transporter
IS499_RS01940	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IS499_RS01945	COG1047	Peptidyl-prolyl cis-trans
IS499_RS01955	COG0545	Peptidyl-prolyl cis-trans isomerase
IS499_RS01960	COG2964	Protein conserved in bacteria
IS499_RS02015	COG0051	transcription antitermination factor activity, RNA binding
IS499_RS02040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IS499_RS02055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IS499_RS02120	COG0201	protein transport
IS499_RS02145	COG0202	RNA polymerase activity
IS499_RS02160	COG0789	Transcriptional regulator
IS499_RS02165	COG3036	rescue of stalled ribosome
IS499_RS02195	COG0758	DNA mediated transformation
IS499_RS02205	COG0551	DNA topoisomerase type I activity
IS499_RS02225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS499_RS02260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS499_RS02265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS02270	COG1309	transcriptional regulator
IS499_RS02275	COG0582	viral genome integration into host DNA
IS499_RS02290	COG3561	AntA/AntB antirepressor
IS499_RS02375	COG1802	Transcriptional regulator
IS499_RS02375	COG4626	Terminase
IS499_RS02400	COG4145	pantothenate transmembrane transporter activity
IS499_RS02405	COG3924	membrane
IS499_RS02410	COG0439	Biotin carboxylase
IS499_RS02415	COG0511	ligase activity, forming carbon-carbon bonds
IS499_RS02440	COG2199	diguanylate cyclase activity
IS499_RS02440	COG2200	EAL domain
IS499_RS02445	COG1077	Cell shape determining protein MreB Mrl
IS499_RS02450	COG1792	Involved in formation and maintenance of cell shape
IS499_RS02455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IS499_RS02465	COG1530	ribonuclease E activity
IS499_RS02470	COG3164	Protein of unknown function
IS499_RS02475	COG0312	modulator of DNA gyrase
IS499_RS02480	COG0583	DNA-binding transcription factor activity
IS499_RS02495	COG1289	transmembrane transporter activity
IS499_RS02500	COG2732	(Barnase) inhibitor
IS499_RS02525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS499_RS02530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS499_RS02535	COG3105	Protein conserved in bacteria
IS499_RS02540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS499_RS02560	COG0625	glutathione transferase activity
IS499_RS02565	COG2969	positive regulation of protein catabolic process
IS499_RS02575	COG0493	'glutamate synthase
IS499_RS02580	COG0070	glutamate synthase
IS499_RS02580	COG0069	glutamate synthase activity
IS499_RS02580	COG0067	glutamate synthase
IS499_RS02585	COG1242	4 iron, 4 sulfur cluster binding
IS499_RS02590	COG2271	Major facilitator Superfamily
IS499_RS02595	COG3039	Transposase
IS499_RS02600	COG1063	alcohol dehydrogenase
IS499_RS02605	COG1312	Catalyzes the dehydration of D-mannonate
IS499_RS02610	COG0784	Response regulator, receiver
IS499_RS02610	COG5002	protein histidine kinase activity
IS499_RS02610	COG2198	Histidine kinase
IS499_RS02615	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IS499_RS02620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS499_RS02625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS02635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS02640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS499_RS02645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IS499_RS02650	COG1137	ATPase activity
IS499_RS02655	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IS499_RS02660	COG3117	lipopolysaccharide transmembrane transporter activity
IS499_RS02665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IS499_RS02675	COG0530	calcium, potassium:sodium antiporter activity
IS499_RS02680	COG1127	ABC transporter
IS499_RS02685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS499_RS02690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS499_RS02695	COG2854	intermembrane phospholipid transfer
IS499_RS02700	COG3113	response to antibiotic
IS499_RS02705	COG5007	Belongs to the BolA IbaG family
IS499_RS02715	COG3423	Transcriptional regulator
IS499_RS02720	COG0142	geranyltranstransferase activity
IS499_RS02735	COG0697	spore germination
IS499_RS02745	COG2027	D-alanyl-D-alanine carboxypeptidase
IS499_RS02755	COG1534	Rna-binding protein
IS499_RS02765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IS499_RS02770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IS499_RS02780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IS499_RS02820	COG0195	Participates in both transcription termination and antitermination
IS499_RS02865	COG0814	amino acid
IS499_RS02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS499_RS02875	COG0826	peptidase U32
IS499_RS02880	COG0826	peptidase U32
IS499_RS02885	COG3154	lipid carrier protein
IS499_RS02890	COG3153	acetyltransferase
IS499_RS02905	COG0693	protein deglycase activity
IS499_RS02910	COG0702	epimerase
IS499_RS02915	COG0701	Predicted permease
IS499_RS02920	COG2823	Periplasmic or secreted lipoprotein
IS499_RS02940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IS499_RS02955	COG1063	alcohol dehydrogenase
IS499_RS02960	COG3775	system Galactitol-specific IIC component
IS499_RS02965	COG3414	Phosphotransferase system galactitol-specific IIB component
IS499_RS02970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS02980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS02980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS02985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS499_RS02985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS499_RS02985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS02990	COG1105	Belongs to the carbohydrate kinase PfkB family
IS499_RS03000	COG1349	DNA-binding transcription factor activity
IS499_RS03005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS03010	COG2721	sulfolactate sulfo-lyase activity
IS499_RS03015	COG2271	Major facilitator Superfamily
IS499_RS03025	COG2084	Dehydrogenase
IS499_RS03030	COG1929	Belongs to the glycerate kinase type-1 family
IS499_RS03055	COG1741	Belongs to the pirin family
IS499_RS03060	COG0583	DNA-binding transcription factor activity
IS499_RS03065	COG3152	Membrane
IS499_RS03070	COG0435	Glutathione S-transferase
IS499_RS03075	COG2259	Doxx family
IS499_RS03085	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IS499_RS03090	COG4575	ribosome binding
IS499_RS03095	COG1422	Protein of unknown function (DUF1090)
IS499_RS03105	COG0586	Pfam SNARE associated Golgi protein
IS499_RS03110	COG2186	Transcriptional regulator
IS499_RS03115	COG2271	Major facilitator Superfamily
IS499_RS03125	COG2721	sulfolactate sulfo-lyase activity
IS499_RS03140	COG0861	Integral membrane protein TerC family
IS499_RS03145	COG0673	inositol 2-dehydrogenase activity
IS499_RS03150	COG1451	nucleotide metabolic process
IS499_RS03170	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS499_RS03170	COG1902	pentaerythritol trinitrate reductase activity
IS499_RS03220	COG1695	Transcriptional regulator
IS499_RS03225	COG2375	cellular response to nickel ion
IS499_RS03240	COG1461	Dihydroxyacetone kinase
IS499_RS03245	COG2376	Dihydroxyacetone kinase
IS499_RS03315	COG3247	response to pH
IS499_RS03325	COG2198	Histidine kinase
IS499_RS03325	COG0784	Response regulator, receiver
IS499_RS03325	COG2205	protein histidine kinase activity
IS499_RS03325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS03330	COG2197	response regulator
IS499_RS03355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS499_RS03360	COG0358	DNA primase activity
IS499_RS03365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IS499_RS03435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS499_RS03450	COG4991	sh3 domain protein
IS499_RS03455	COG3025	triphosphatase activity
IS499_RS03480	COG2960	long-chain fatty acid transporting porin activity
IS499_RS03495	COG3384	dioxygenase
IS499_RS03500	COG0754	glutathionylspermidine amidase activity
IS499_RS03515	COG0494	nUDIX hydrolase
IS499_RS03520	COG3151	Protein conserved in bacteria
IS499_RS03525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS499_RS03530	COG3150	esterase
IS499_RS03540	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IS499_RS03545	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS499_RS03550	COG0642	Histidine kinase
IS499_RS03560	COG3111	PFAM Bacterial OB fold (BOF) protein
IS499_RS03565	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IS499_RS03570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IS499_RS03575	COG0204	Acyl-transferase
IS499_RS03580	COG2132	Multicopper oxidase
IS499_RS03585	COG1032	radical SAM domain protein
IS499_RS03595	COG0656	L-ascorbic acid biosynthetic process
IS499_RS03600	COG1979	alcohol dehydrogenase
IS499_RS03605	COG2207	Transcriptional regulator
IS499_RS03610	COG0586	Pfam SNARE associated Golgi protein
IS499_RS03615	COG0626	cystathionine gamma-synthase activity
IS499_RS03625	COG0848	biopolymer transport protein
IS499_RS03630	COG2211	Major facilitator Superfamily
IS499_RS03655	COG0625	glutathione transferase activity
IS499_RS03670	COG0754	glutathionylspermidine amidase activity
IS499_RS03675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS499_RS03695	COG0583	DNA-binding transcription factor activity
IS499_RS03700	COG0626	cystathionine gamma-synthase activity
IS499_RS03910	COG3039	Transposase
IS499_RS03960	COG3423	Transcriptional regulator
IS499_RS03970	COG1278	Cold shock
IS499_RS03975	COG3423	Transcriptional regulator
IS499_RS04040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS499_RS04050	COG1811	Na channel or pump
IS499_RS04055	COG1982	Orn Lys Arg decarboxylase major
IS499_RS04060	COG2211	Major facilitator Superfamily
IS499_RS04075	COG1194	a g-specific adenine glycosylase
IS499_RS04085	COG3171	Protein conserved in bacteria
IS499_RS04095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS499_RS04110	COG0762	integral membrane protein
IS499_RS04115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IS499_RS04120	COG2805	Type II/IV secretion system protein
IS499_RS04140	COG0189	ligase activity
IS499_RS04145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IS499_RS04150	COG2356	endonuclease I
IS499_RS04160	COG2814	Major facilitator Superfamily
IS499_RS04195	COG2146	nitrite reductase [NAD(P)H] activity
IS499_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS04215	COG1414	Transcriptional regulator
IS499_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS04250	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IS499_RS04280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS499_RS04295	COG0191	fructose-bisphosphate aldolase activity
IS499_RS04300	COG0668	transmembrane transport
IS499_RS04310	COG2968	Membrane
IS499_RS04325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS499_RS04330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IS499_RS04350	COG0006	proline dipeptidase activity
IS499_RS04355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS499_RS04360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS499_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS04385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS499_RS04405	COG2723	6-phospho-beta-galactosidase activity
IS499_RS04410	COG1737	Transcriptional regulator
IS499_RS04420	COG1272	protein, Hemolysin III
IS499_RS04430	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IS499_RS04440	COG0716	FMN binding
IS499_RS04445	COG4974	Belongs to the 'phage' integrase family
IS499_RS04455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IS499_RS04475	COG4942	peptidase
IS499_RS04485	COG2814	Major facilitator Superfamily
IS499_RS04500	COG0667	Aldo Keto reductase
IS499_RS04535	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS499_RS04540	COG1393	Belongs to the ArsC family
IS499_RS04555	COG1538	Outer membrane efflux protein
IS499_RS04560	COG1289	transmembrane transporter activity
IS499_RS04575	COG3592	Divergent 4Fe-4S mono-cluster
IS499_RS04580	COG2388	GCN5-related N-acetyl-transferase
IS499_RS04590	COG3539	Fimbrial protein
IS499_RS04595	COG3539	Fimbrial protein
IS499_RS04600	COG3539	Fimbrial protein
IS499_RS04605	COG3188	usher protein
IS499_RS04610	COG3121	Chaperone
IS499_RS04615	COG3539	Fimbrial protein
IS499_RS04625	COG4974	Belongs to the 'phage' integrase family
IS499_RS04630	COG0582	viral genome integration into host DNA
IS499_RS04635	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS499_RS04640	COG1846	Transcriptional regulator
IS499_RS04645	COG0697	spore germination
IS499_RS04695	COG0667	Aldo Keto reductase
IS499_RS04700	COG0814	amino acid
IS499_RS04715	COG0183	Belongs to the thiolase family
IS499_RS04725	COG0823	Involved in the tonB-independent uptake of proteins
IS499_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS04735	COG2814	Major facilitator Superfamily
IS499_RS04770	COG3842	ATPase activity
IS499_RS04775	COG0395	ABC-type sugar transport system, permease component
IS499_RS04780	COG1175	transmembrane transport
IS499_RS04785	COG1917	Cupin 2, conserved barrel domain protein
IS499_RS04790	COG1794	racemase activity, acting on amino acids and derivatives
IS499_RS04795	COG0583	DNA-binding transcription factor activity
IS499_RS04805	COG1609	Transcriptional regulator
IS499_RS04810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS04815	COG2723	6-phospho-beta-galactosidase activity
IS499_RS04820	COG2186	Transcriptional regulator
IS499_RS04830	COG1609	Transcriptional regulator
IS499_RS04850	COG0667	Aldo Keto reductase
IS499_RS04860	COG0861	Integral membrane protein TerC family
IS499_RS04895	COG2165	general secretion pathway protein
IS499_RS04900	COG4795	General secretion pathway protein
IS499_RS04910	COG4967	type IV pilus modification protein PilV
IS499_RS04915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IS499_RS04920	COG1025	Belongs to the peptidase M16 family
IS499_RS04925	COG1074	ATP-dependent DNA helicase activity
IS499_RS04930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IS499_RS04940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IS499_RS04940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IS499_RS04945	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS499_RS04950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS499_RS04980	COG4656	Part of a membrane complex involved in electron transport
IS499_RS04985	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS04985	COG1454	alcohol dehydrogenase
IS499_RS05015	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IS499_RS05180	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IS499_RS05185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IS499_RS05190	COG2166	iron-sulfur cluster assembly
IS499_RS05195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS499_RS05205	COG0583	DNA-binding transcription factor activity
IS499_RS05210	COG2363	Small membrane protein
IS499_RS05220	COG1349	DNA-binding transcription factor activity
IS499_RS05240	COG0738	Major facilitator superfamily
IS499_RS05245	COG0235	Class ii aldolase
IS499_RS05250	COG1454	alcohol dehydrogenase
IS499_RS05270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS499_RS05285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS499_RS05290	COG2011	ABC-type metal ion transport system permease component
IS499_RS05295	COG1464	Belongs to the NlpA lipoprotein family
IS499_RS05300	COG0477	Major facilitator Superfamily
IS499_RS05310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS499_RS05315	COG1760	l-serine dehydratase
IS499_RS05320	COG0814	amino acid
IS499_RS05325	COG1611	Belongs to the LOG family
IS499_RS05340	COG3098	single-species biofilm formation
IS499_RS05345	COG0564	pseudouridine synthase activity
IS499_RS05350	COG0716	FMN binding
IS499_RS05355	COG2271	Major facilitator Superfamily
IS499_RS05360	COG4948	Mandelate Racemase Muconate Lactonizing
IS499_RS05365	COG4948	Mandelate Racemase Muconate Lactonizing
IS499_RS05370	COG1929	Belongs to the glycerate kinase type-1 family
IS499_RS05375	COG2205	protein histidine kinase activity
IS499_RS05375	COG4999	Histidine kinase
IS499_RS05375	COG3437	response regulator, receiver
IS499_RS05375	COG3850	Histidine kinase
IS499_RS05385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS499_RS05390	COG3956	TIGRFAM MazG family protein
IS499_RS05410	COG0602	queuosine metabolic process
IS499_RS05415	COG0720	synthase
IS499_RS05435	COG2234	aminopeptidase activity
IS499_RS05495	COG1388	LysM domain
IS499_RS05495	COG4942	peptidase
IS499_RS05500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS499_RS05525	COG0163	prenyltransferase activity
IS499_RS05530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS499_RS05570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS05575	COG4558	Periplasmic binding protein
IS499_RS05580	COG3720	iron ion transport
IS499_RS05600	COG0679	Auxin Efflux Carrier
IS499_RS05615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS499_RS05620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS499_RS05625	COG1121	(ABC) transporter
IS499_RS05630	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS499_RS05635	COG1609	Transcriptional regulator
IS499_RS05640	COG1940	carbohydrate kinase activity
IS499_RS05645	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS499_RS05650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS05655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS05660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS05665	COG4580	involved in the transport of maltose and maltodextrins
IS499_RS05675	COG2723	6-phospho-beta-galactosidase activity
IS499_RS05685	COG0309	Hydrogenase expression formation protein (HypE)
IS499_RS05690	COG0409	Hydrogenase expression formation protein
IS499_RS05695	COG0298	carbon dioxide binding
IS499_RS05700	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IS499_RS05715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS499_RS05720	COG0651	ATP synthesis coupled electron transport
IS499_RS05725	COG0650	Formate hydrogenlyase subunit 4
IS499_RS05730	COG3261	NADH dehydrogenase
IS499_RS05730	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IS499_RS05735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS499_RS05740	COG3260	NADH ubiquinone oxidoreductase 20
IS499_RS05750	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IS499_RS05760	COG2723	6-phospho-beta-galactosidase activity
IS499_RS05765	COG1263	PTS System
IS499_RS05765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS05770	COG1609	Transcriptional regulator
IS499_RS05775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS499_RS05780	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IS499_RS05785	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IS499_RS05810	COG1349	DNA-binding transcription factor activity
IS499_RS05815	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS05830	COG3732	PTS system glucitol sorbitol-specific
IS499_RS05835	COG3730	PTS system glucitol sorbitol-specific
IS499_RS05840	COG2951	lytic endotransglycosylase activity
IS499_RS05845	COG1121	(ABC) transporter
IS499_RS05850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS499_RS05855	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS499_RS05860	COG1546	Belongs to the CinA family
IS499_RS05880	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IS499_RS05910	COG2823	Periplasmic or secreted lipoprotein
IS499_RS05915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS499_RS05920	COG1238	metal cluster binding
IS499_RS05940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IS499_RS05945	COG2814	Major facilitator Superfamily
IS499_RS05950	COG1566	PFAM secretion protein HlyD family protein
IS499_RS05955	COG1846	Transcriptional regulator
IS499_RS05965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IS499_RS05975	COG4176	ABC-type proline glycine betaine transport system permease component
IS499_RS05990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS499_RS06000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS499_RS06005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS499_RS06010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS499_RS06015	COG4575	ribosome binding
IS499_RS06030	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS499_RS06045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS499_RS06050	COG0640	Transcriptional regulator
IS499_RS06060	COG0583	DNA-binding transcription factor activity
IS499_RS06065	COG3284	Transcriptional regulator
IS499_RS06080	COG4974	Belongs to the 'phage' integrase family
IS499_RS06115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS499_RS06130	COG3344	reverse transcriptase
IS499_RS06165	COG4695	Portal protein
IS499_RS06330	COG2867	negative regulation of translational initiation
IS499_RS06345	COG0497	DNA recombination
IS499_RS06360	COG4536	flavin adenine dinucleotide binding
IS499_RS06365	COG4137	Cytochrome C assembly protein
IS499_RS06370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IS499_RS06405	COG2885	chlorophyll binding
IS499_RS06410	COG2199	diguanylate cyclase activity
IS499_RS06420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS499_RS06425	COG1605	Chorismate mutase
IS499_RS06425	COG0287	Prephenate dehydrogenase
IS499_RS06435	COG0077	Prephenate dehydratase
IS499_RS06435	COG1605	Chorismate mutase
IS499_RS06445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS499_RS06450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS499_RS06465	COG0542	response to heat
IS499_RS06490	COG0477	Major facilitator Superfamily
IS499_RS06495	COG5544	Lipoprotein
IS499_RS06500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS499_RS06510	COG3148	PFAM DTW domain containing protein
IS499_RS06515	COG3118	belongs to the thioredoxin family
IS499_RS06520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS499_RS06535	COG0513	Belongs to the DEAD box helicase family
IS499_RS06545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IS499_RS06560	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IS499_RS06565	COG3026	antisigma factor binding
IS499_RS06570	COG3086	response to oxidative stress
IS499_RS06580	COG0681	Belongs to the peptidase S26 family
IS499_RS06600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS499_RS06610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS499_RS06615	COG1737	Transcriptional regulator
IS499_RS06620	COG0560	Phosphoserine phosphatase
IS499_RS06635	COG0047	phosphoribosylformylglycinamidine synthase activity
IS499_RS06635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IS499_RS06640	COG2205	protein histidine kinase activity
IS499_RS06645	COG3170	Tfp pilus assembly protein FimV
IS499_RS06650	COG2204	response regulator
IS499_RS06655	COG0347	Belongs to the P(II) protein family
IS499_RS06660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS499_RS06660	COG1017	nitric oxide dioxygenase activity
IS499_RS06670	COG2259	Doxx family
IS499_RS06675	COG1940	carbohydrate kinase activity
IS499_RS06680	COG0457	Tetratricopeptide repeat
IS499_RS06685	COG0477	Major facilitator Superfamily
IS499_RS06685	COG2814	Major facilitator Superfamily
IS499_RS06690	COG2017	converts alpha-aldose to the beta-anomer
IS499_RS06695	COG2814	Major facilitator Superfamily
IS499_RS06700	COG3711	transcriptional antiterminator
IS499_RS06705	COG3683	transport system, periplasmic component
IS499_RS06710	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS499_RS06745	COG0822	iron-sulfur transferase activity
IS499_RS06765	COG0633	Ferredoxin
IS499_RS06770	COG2975	iron-sulfur cluster assembly
IS499_RS06790	COG2897	thiosulfate sulfurtransferase activity
IS499_RS06795	COG2373	Large extracellular alpha-helical protein
IS499_RS06800	COG4953	penicillin-binding protein 1C
IS499_RS06830	COG2976	Protein conserved in bacteria
IS499_RS06850	COG1645	bacterial-type flagellum-dependent swarming motility
IS499_RS06860	COG0516	GMP reductase activity
IS499_RS06860	COG0517	IMP dehydrogenase activity
IS499_RS06905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS499_RS06985	COG3344	reverse transcriptase
IS499_RS06995	COG5484	DNA packaging
IS499_RS06995	COG3728	DNA packaging
IS499_RS07090	COG3617	BRO family, N-terminal domain
IS499_RS07120	COG3179	chitinase
IS499_RS07130	COG3119	arylsulfatase activity
IS499_RS07135	COG0641	radical SAM
IS499_RS07155	COG2200	EAL domain
IS499_RS07170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IS499_RS07185	COG2723	6-phospho-beta-galactosidase activity
IS499_RS07195	COG2233	PERMEase
IS499_RS07210	COG1393	Belongs to the ArsC family
IS499_RS07215	COG4783	chaperone-mediated protein folding
IS499_RS07225	COG0628	permease
IS499_RS07230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IS499_RS07235	COG2716	regulation of RNA biosynthetic process
IS499_RS07245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IS499_RS07255	COG2321	neutral zinc metallopeptidase
IS499_RS07260	COG1444	tRNA N-acetyltransferase activity
IS499_RS07265	COG0400	carboxylic ester hydrolase activity
IS499_RS07280	COG1393	Belongs to the ArsC family
IS499_RS07290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS499_RS07295	COG0493	'glutamate synthase
IS499_RS07295	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS499_RS07305	COG5342	invasion associated locus B
IS499_RS07310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS499_RS07315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS499_RS07325	COG4810	utilization protein
IS499_RS07415	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS499_RS07435	COG2837	iron assimilation
IS499_RS07445	COG4150	thiosulfate binding
IS499_RS07450	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IS499_RS07455	COG4208	sulfate ABC transporter
IS499_RS07460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IS499_RS07470	COG4319	ketosteroid isomerase
IS499_RS07505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IS499_RS07525	COG3530	Putative quorum-sensing-regulated virulence factor
IS499_RS07530	COG0385	Bile acid
IS499_RS07535	COG0583	DNA-binding transcription factor activity
IS499_RS07565	COG3415	Transposase
IS499_RS07570	COG3415	Transposase
IS499_RS07585	COG2200	EAL domain
IS499_RS07585	COG2199	diguanylate cyclase activity
IS499_RS07590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS499_RS07605	COG0667	Aldo Keto reductase
IS499_RS07610	COG3961	Belongs to the TPP enzyme family
IS499_RS07625	COG3279	Response regulator of the LytR AlgR family
IS499_RS07630	COG3275	phosphorelay sensor kinase activity
IS499_RS07645	COG0436	Aminotransferase
IS499_RS07655	COG2807	transmembrane transport
IS499_RS07660	COG0590	tRNA wobble adenosine to inosine editing
IS499_RS07665	COG0583	DNA-binding transcription factor activity
IS499_RS07685	COG2116	formate transmembrane transporter activity
IS499_RS07690	COG2853	Lipoprotein
IS499_RS07700	COG3691	Protein conserved in bacteria
IS499_RS07715	COG2062	phosphohistidine phosphatase, SixA
IS499_RS07740	COG0730	response to heat
IS499_RS07745	COG3101	peptidyl-lysine hydroxylation
IS499_RS07760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS499_RS07780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS499_RS07790	COG0586	Pfam SNARE associated Golgi protein
IS499_RS07800	COG0285	dihydrofolate synthase activity
IS499_RS07805	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IS499_RS07810	COG1286	toxin biosynthetic process
IS499_RS07815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IS499_RS07820	COG0163	prenyltransferase activity
IS499_RS07845	COG4160	amino acid transport
IS499_RS07850	COG4598	ABC transporter
IS499_RS07865	COG1090	epimerase
IS499_RS07870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS499_RS07875	COG0625	glutathione transferase activity
IS499_RS07880	COG0625	glutathione transferase activity
IS499_RS07885	COG0622	Phosphoesterase
IS499_RS07890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IS499_RS07895	COG0280	phosphate acetyltransferase
IS499_RS07895	COG0857	belongs to the CobB CobQ family
IS499_RS07915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS499_RS07920	COG0471	metal ion transport
IS499_RS07920	COG0490	domain, Protein
IS499_RS07930	COG0436	Aminotransferase
IS499_RS07935	COG0583	DNA-binding transcription factor activity
IS499_RS07980	COG0839	Belongs to the complex I subunit 6 family
IS499_RS07990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IS499_RS07995	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS499_RS08010	COG2153	protein acetylation
IS499_RS08015	COG1169	isochorismate synthase
IS499_RS08040	COG0318	PFAM AMP-dependent synthetase and ligase
IS499_RS08050	COG5464	transposase or invertase
IS499_RS08065	COG1414	Transcriptional regulator
IS499_RS08075	COG2271	Major facilitator Superfamily
IS499_RS08085	COG0247	lactate metabolic process
IS499_RS08095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS499_RS08105	COG2271	Major facilitator Superfamily
IS499_RS08110	COG0584	glycerophosphoryl diester phosphodiesterase
IS499_RS08115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS499_RS08140	COG2205	protein histidine kinase activity
IS499_RS08140	COG0784	Response regulator, receiver
IS499_RS08150	COG2198	Histidine kinase
IS499_RS08150	COG0642	Histidine kinase
IS499_RS08165	COG2169	Transcriptional regulator
IS499_RS08165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS499_RS08170	COG3145	DNA-N1-methyladenine dioxygenase activity
IS499_RS08175	COG4615	Cyclic peptide transporter
IS499_RS08180	COG2239	Acts as a magnesium transporter
IS499_RS08185	COG0659	secondary active sulfate transmembrane transporter activity
IS499_RS08200	COG0628	permease
IS499_RS08225	COG1349	DNA-binding transcription factor activity
IS499_RS08230	COG0494	nUDIX hydrolase
IS499_RS08250	COG1061	Type III restriction enzyme res subunit
IS499_RS08255	COG1187	pseudouridine synthase activity
IS499_RS08260	COG2814	Major facilitator Superfamily
IS499_RS08270	COG4172	Belongs to the ABC transporter superfamily
IS499_RS08275	COG4239	(ABC) transporter, permease
IS499_RS08280	COG4174	ABC transporter (Permease)
IS499_RS08285	COG4166	transmembrane transport
IS499_RS08290	COG2200	EAL domain
IS499_RS08295	COG0791	NLP P60 protein
IS499_RS08300	COG0671	phosphoesterase, PA-phosphatase related
IS499_RS08305	COG0523	cobalamin synthesis protein
IS499_RS08310	COG0246	Mannitol dehydrogenase
IS499_RS08315	COG1312	Catalyzes the dehydration of D-mannonate
IS499_RS08340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS08340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS08345	COG1105	Belongs to the carbohydrate kinase PfkB family
IS499_RS08350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS499_RS08350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS499_RS08350	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS499_RS08360	COG2855	membrane
IS499_RS08365	COG0583	DNA-binding transcription factor activity
IS499_RS08370	COG0833	amino acid
IS499_RS08380	COG4771	TonB-dependent receptor
IS499_RS08395	COG2311	Membrane
IS499_RS08410	COG1129	ABC transporter
IS499_RS08420	COG2949	membrane
IS499_RS08430	COG1346	cytolysis
IS499_RS08440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS499_RS08445	COG3659	wide pore channel activity
IS499_RS08460	COG2723	6-phospho-beta-galactosidase activity
IS499_RS08465	COG1538	Outer membrane efflux protein
IS499_RS08470	COG0586	Pfam SNARE associated Golgi protein
IS499_RS08480	COG1686	Belongs to the peptidase S11 family
IS499_RS08495	COG0277	FAD linked oxidase domain protein
IS499_RS08500	COG1472	Belongs to the glycosyl hydrolase 3 family
IS499_RS08505	COG1732	Glycine betaine
IS499_RS08510	COG1174	glycine betaine transport
IS499_RS08515	COG1125	glycine betaine transport
IS499_RS08520	COG1174	glycine betaine transport
IS499_RS08530	COG3275	phosphorelay sensor kinase activity
IS499_RS08540	COG4807	Protein conserved in bacteria
IS499_RS08560	COG5455	response to cobalt ion
IS499_RS08565	COG0583	DNA-binding transcription factor activity
IS499_RS08570	COG2252	PERMEase
IS499_RS08580	COG0583	DNA-binding transcription factor activity
IS499_RS08595	COG0351	phosphomethylpyrimidine kinase
IS499_RS08600	COG1830	Aldolase
IS499_RS08610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS499_RS08635	COG1070	Carbohydrate kinase
IS499_RS08645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS499_RS08650	COG4948	Mandelate Racemase Muconate Lactonizing
IS499_RS08655	COG0747	negative chemotaxis
IS499_RS08660	COG0601	transmembrane transport
IS499_RS08665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS499_RS08670	COG0444	Belongs to the ABC transporter superfamily
IS499_RS08675	COG4608	Belongs to the ABC transporter superfamily
IS499_RS08685	COG0826	peptidase U32
IS499_RS08690	COG0745	RESPONSE REGULATOR receiver
IS499_RS08695	COG2205	protein histidine kinase activity
IS499_RS08720	COG1301	dicarboxylic acid transport
IS499_RS08745	COG5002	protein histidine kinase activity
IS499_RS08750	COG0443	Heat shock 70 kDa protein
IS499_RS08755	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IS499_RS08770	COG2982	Protein involved in outer membrane biogenesis
IS499_RS08775	COG1253	flavin adenine dinucleotide binding
IS499_RS08830	COG1215	transferase activity, transferring glycosyl groups
IS499_RS08840	COG0438	transferase activity, transferring glycosyl groups
IS499_RS08875	COG1088	dTDP-glucose 4,6-dehydratase activity
IS499_RS08900	COG3039	Transposase
IS499_RS08950	COG0438	transferase activity, transferring glycosyl groups
IS499_RS08955	COG1215	transferase activity, transferring glycosyl groups
IS499_RS08975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IS499_RS09005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS499_RS09010	COG0583	DNA-binding transcription factor activity
IS499_RS09020	COG0531	amino acid
IS499_RS09025	COG0640	Transcriptional regulator
IS499_RS09030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS499_RS09040	COG2925	Exonuclease
IS499_RS09050	COG3344	reverse transcriptase
IS499_RS09060	COG1289	transmembrane transporter activity
IS499_RS09080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IS499_RS09090	COG1942	4-Oxalocrotonate Tautomerase
IS499_RS09095	COG0583	DNA-binding transcription factor activity
IS499_RS09100	COG0095	Lipoate-protein ligase
IS499_RS09105	COG0477	Major facilitator Superfamily
IS499_RS09115	COG5001	Diguanylate cyclase
IS499_RS09115	COG3300	MHYT domain
IS499_RS09125	COG3615	Tellurite resistance protein tehB
IS499_RS09150	COG3706	GGDEF domain
IS499_RS09200	COG2003	Belongs to the UPF0758 family
IS499_RS09245	COG3504	Conjugal transfer protein
IS499_RS09315	COG4771	TonB-dependent receptor
IS499_RS09320	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS499_RS09340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS499_RS09340	COG2226	methyltransferase
IS499_RS09340	COG3433	isochorismatase activity
IS499_RS09355	COG1132	(ABC) transporter
IS499_RS09360	COG2814	Major facilitator Superfamily
IS499_RS09365	COG1169	isochorismate synthase
IS499_RS09370	COG0582	viral genome integration into host DNA
IS499_RS09380	COG0534	Mate efflux family protein
IS499_RS09390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IS499_RS09410	COG0604	alcohol dehydrogenase
IS499_RS09420	COG0025	NhaP-type Na H and K H
IS499_RS09465	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS499_RS09475	COG1418	mRNA catabolic process
IS499_RS09480	COG0270	DNA (cytosine-5-)-methyltransferase activity
IS499_RS09485	COG3727	T/G mismatch-specific endonuclease activity
IS499_RS09490	COG0697	spore germination
IS499_RS09495	COG2354	Protein conserved in bacteria
IS499_RS09525	COG0366	Alpha amylase catalytic
IS499_RS09530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS09540	COG0765	amino acid transport
IS499_RS09545	COG1126	abc transporter atp-binding protein
IS499_RS09550	COG2197	response regulator
IS499_RS09560	COG2197	response regulator
IS499_RS09595	COG3012	SEC-C Motif Domain Protein
IS499_RS09595	COG3318	Belongs to the UPF0149 family
IS499_RS09600	COG0814	amino acid
IS499_RS09610	COG1528	Iron-storage protein
IS499_RS09625	COG0477	Major facilitator Superfamily
IS499_RS09635	COG2211	Major facilitator Superfamily
IS499_RS09645	COG1528	Iron-storage protein
IS499_RS09655	COG1879	ABC-type sugar transport system periplasmic component
IS499_RS09665	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS09690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IS499_RS09700	COG3102	Protein conserved in bacteria
IS499_RS09720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IS499_RS09725	COG1801	Protein of unknown function DUF72
IS499_RS09730	COG1335	isochorismatase
IS499_RS09740	COG0494	nUDIX hydrolase
IS499_RS09765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS499_RS09775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IS499_RS09780	COG0739	heme binding
IS499_RS09785	COG1560	Kdo2-lipid A biosynthetic process
IS499_RS09795	COG1737	Transcriptional regulator
IS499_RS09805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS499_RS09810	COG0129	dihydroxy-acid dehydratase activity
IS499_RS09815	COG0800	Aldolase
IS499_RS09825	COG3141	response to X-ray
IS499_RS09830	COG2979	Protein of unknown function (DUF533)
IS499_RS09835	COG1770	oligopeptidase
IS499_RS09840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS499_RS09850	COG2372	response to copper ion
IS499_RS09855	COG1276	copper resistance
IS499_RS09870	COG2990	Protein conserved in bacteria
IS499_RS09895	COG3008	intermembrane lipid transfer
IS499_RS09900	COG2995	paraquat-inducible protein a
IS499_RS09905	COG1956	GAF domain-containing protein
IS499_RS09925	COG2814	Major facilitator Superfamily
IS499_RS09930	COG1414	Transcriptional regulator
IS499_RS09960	COG0768	penicillin binding
IS499_RS09965	COG2226	methyltransferase
IS499_RS09980	COG3716	PTS system mannose fructose sorbose family IID component
IS499_RS09985	COG3715	PTS system
IS499_RS09990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS09990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS09995	COG1253	flavin adenine dinucleotide binding
IS499_RS10000	COG2200	EAL domain
IS499_RS10005	COG1760	l-serine dehydratase
IS499_RS10025	COG0251	oxidation-reduction process
IS499_RS10030	COG1199	ATP-dependent helicase activity
IS499_RS10040	COG3065	identical protein binding
IS499_RS10050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IS499_RS10060	COG2894	cell division
IS499_RS10075	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS499_RS10105	COG2719	SpoVR family
IS499_RS10130	COG1619	proteins homologs of microcin C7 resistance protein MccF
IS499_RS10140	COG4774	siderophore transport
IS499_RS10155	COG2308	Evidence 4 Homologs of previously reported genes of
IS499_RS10195	COG0583	DNA-binding transcription factor activity
IS499_RS10200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS499_RS10215	COG1882	Formate acetyltransferase
IS499_RS10250	COG0583	DNA-binding transcription factor activity
IS499_RS10280	COG0583	DNA-binding transcription factor activity
IS499_RS10295	COG3122	Protein conserved in bacteria
IS499_RS10315	COG2885	chlorophyll binding
IS499_RS10390	COG3436	PFAM IS66 Orf2 family protein
IS499_RS10395	COG4372	Transposase
IS499_RS10485	COG0012	GTP binding
IS499_RS10505	COG0659	secondary active sulfate transmembrane transporter activity
IS499_RS10535	COG2890	protein-(glutamine-N5) methyltransferase activity
IS499_RS10555	COG0387	Pfam Sodium calcium exchanger
IS499_RS10560	COG4572	Cation transport regulator
IS499_RS10565	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IS499_RS10575	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IS499_RS10580	COG3707	response regulator
IS499_RS10585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS499_RS10595	COG1116	anion transmembrane transporter activity
IS499_RS10600	COG2146	nitrite reductase [NAD(P)H] activity
IS499_RS10600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS499_RS10605	COG0243	molybdopterin cofactor binding
IS499_RS10610	COG4932	domain protein
IS499_RS10615	COG2197	response regulator
IS499_RS10620	COG3850	Histidine kinase
IS499_RS10625	COG2223	nitrite transmembrane transporter activity
IS499_RS10635	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS499_RS10640	COG1140	nitrate reductase beta subunit
IS499_RS10645	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS499_RS10650	COG2181	nitrate reductase activity
IS499_RS10660	COG1522	sequence-specific DNA binding
IS499_RS10695	COG0788	formyltetrahydrofolate deformylase activity
IS499_RS10705	COG1752	Esterase of the alpha-beta hydrolase superfamily
IS499_RS10710	COG0745	RESPONSE REGULATOR receiver
IS499_RS10715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IS499_RS10720	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS499_RS10730	COG1435	thymidine kinase activity
IS499_RS10735	COG1454	alcohol dehydrogenase
IS499_RS10735	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS10745	COG2095	MarC family integral membrane protein
IS499_RS10750	COG4166	transmembrane transport
IS499_RS10755	COG0601	transmembrane transport
IS499_RS10760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS499_RS10765	COG0444	Belongs to the ABC transporter superfamily
IS499_RS10775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS499_RS10795	COG2353	YceI-like domain
IS499_RS10805	COG2350	Protein conserved in bacteria
IS499_RS10815	COG3001	Fructosamine kinase
IS499_RS10825	COG1105	Belongs to the carbohydrate kinase PfkB family
IS499_RS10830	COG3137	Salt-induced outer membrane protein
IS499_RS10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS499_RS10870	COG0072	phenylalanine-tRNA ligase activity
IS499_RS10890	COG0583	DNA-binding transcription factor activity
IS499_RS10910	COG0386	Belongs to the glutathione peroxidase family
IS499_RS10920	COG0791	NLP P60 protein
IS499_RS10930	COG4256	Hemin uptake protein
IS499_RS10935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS499_RS10950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS499_RS10950	COG0574	Belongs to the PEP-utilizing enzyme family
IS499_RS10960	COG0628	permease
IS499_RS10965	COG0277	FAD linked oxidase domain protein
IS499_RS10965	COG0247	lactate metabolic process
IS499_RS10970	COG2050	protein possibly involved in aromatic compounds catabolism
IS499_RS10975	COG2261	transglycosylase associated protein
IS499_RS11000	COG1120	ATPase activity
IS499_RS11005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS11015	COG0583	DNA-binding transcription factor activity
IS499_RS11040	COG1304	FMN binding
IS499_RS11045	COG1309	transcriptional regulator
IS499_RS11065	COG0316	Belongs to the HesB IscA family
IS499_RS11070	COG0719	Fe-S assembly protein
IS499_RS11075	COG0396	ATPase activity
IS499_RS11080	COG0719	Fe-S assembly protein
IS499_RS11095	COG1376	ErfK ybiS ycfS ynhG family protein
IS499_RS11125	COG1309	transcriptional regulator
IS499_RS11130	COG1082	Xylose isomerase domain protein TIM barrel
IS499_RS11130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IS499_RS11135	COG2271	Major facilitator Superfamily
IS499_RS11140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS499_RS11150	COG1120	ATPase activity
IS499_RS11155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS11160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS499_RS11165	COG1414	Transcriptional regulator
IS499_RS11200	COG2814	Major facilitator Superfamily
IS499_RS11220	COG0583	DNA-binding transcription factor activity
IS499_RS11225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS499_RS11245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS499_RS11250	COG1116	anion transmembrane transporter activity
IS499_RS11255	COG4774	siderophore transport
IS499_RS11260	COG1120	ATPase activity
IS499_RS11265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS11270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS11290	COG0765	amino acid transport
IS499_RS11295	COG1126	abc transporter atp-binding protein
IS499_RS11335	COG3383	formate dehydrogenase (NAD+) activity
IS499_RS11340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IS499_RS11350	COG1175	transmembrane transport
IS499_RS11380	COG4133	protoheme IX ABC transporter activity
IS499_RS11385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS499_RS11390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS499_RS11405	COG1138	Cytochrome C-type biogenesis protein
IS499_RS11410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS499_RS11415	COG3088	subunit of a heme lyase
IS499_RS11415	COG4235	cytochrome complex assembly
IS499_RS11435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IS499_RS11470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS499_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS11510	COG2610	gluconate transmembrane transporter activity
IS499_RS11515	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS499_RS11525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS499_RS11535	COG0583	DNA-binding transcription factor activity
IS499_RS11560	COG0277	FAD linked oxidase domain protein
IS499_RS11565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS499_RS11590	COG0402	S-adenosylhomocysteine deaminase activity
IS499_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS11635	COG3321	synthase
IS499_RS11635	COG0604	alcohol dehydrogenase
IS499_RS11665	COG4608	Belongs to the ABC transporter superfamily
IS499_RS11670	COG0444	Belongs to the ABC transporter superfamily
IS499_RS11695	COG0346	lactoylglutathione lyase activity
IS499_RS11700	COG1349	DNA-binding transcription factor activity
IS499_RS11735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IS499_RS11785	COG0307	riboflavin synthase, alpha
IS499_RS11790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS499_RS11795	COG2814	Major facilitator Superfamily
IS499_RS11800	COG0583	DNA-binding transcription factor activity
IS499_RS11815	COG2814	Major facilitator Superfamily
IS499_RS11830	COG0791	NLP P60 protein
IS499_RS11835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS499_RS11845	COG0346	lactoylglutathione lyase activity
IS499_RS11850	COG1902	pentaerythritol trinitrate reductase activity
IS499_RS11855	COG1309	transcriptional regulator
IS499_RS11860	COG3313	Fe-S protein
IS499_RS11865	COG4989	oxidoreductase activity
IS499_RS11870	COG2032	superoxide dismutase activity
IS499_RS11875	COG1289	transmembrane transporter activity
IS499_RS11880	COG1566	PFAM secretion protein HlyD family protein
IS499_RS11895	COG3706	GGDEF domain
IS499_RS11910	COG3895	Periplasmic Protein
IS499_RS11925	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IS499_RS11930	COG0625	glutathione transferase activity
IS499_RS11940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IS499_RS11950	COG4659	FMN binding
IS499_RS11985	COG2723	6-phospho-beta-galactosidase activity
IS499_RS11995	COG0673	inositol 2-dehydrogenase activity
IS499_RS12005	COG2814	Major facilitator Superfamily
IS499_RS12025	COG3038	cytochrome b561
IS499_RS12045	COG0583	DNA-binding transcription factor activity
IS499_RS12050	COG3485	protocatechuate 3,4-dioxygenase
IS499_RS12055	COG3485	protocatechuate 3,4-dioxygenase
IS499_RS12060	COG5383	Protein conserved in bacteria
IS499_RS12065	COG2272	Belongs to the type-B carboxylesterase lipase family
IS499_RS12080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS499_RS12085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS499_RS12090	COG1275	C4-dicarboxylate transporter malic acid transport protein
IS499_RS12095	COG0500	methyltransferase
IS499_RS12110	COG2207	Transcriptional regulator
IS499_RS12110	COG3708	Transcriptional regulator
IS499_RS12115	COG3135	benzoate transporter
IS499_RS12120	COG1396	sequence-specific DNA binding
IS499_RS12130	COG0826	peptidase U32
IS499_RS12150	COG1294	oxidase, subunit
IS499_RS12155	COG1271	oxidase subunit
IS499_RS12160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS499_RS12165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS499_RS12170	COG3842	ATPase activity
IS499_RS12175	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS499_RS12180	COG1177	transmembrane transport
IS499_RS12185	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS12220	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS12225	COG0747	negative chemotaxis
IS499_RS12235	COG3238	Protein conserved in bacteria
IS499_RS12240	COG1247	-acetyltransferase
IS499_RS12250	COG2130	NADP-dependent
IS499_RS12265	COG3691	Protein conserved in bacteria
IS499_RS12270	COG1228	amidohydrolase
IS499_RS12275	COG4772	TonB-dependent receptor
IS499_RS12300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS499_RS12305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS499_RS12310	COG1473	amidohydrolase
IS499_RS12315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS499_RS12320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS12330	COG0765	amino acid transport
IS499_RS12335	COG1126	abc transporter atp-binding protein
IS499_RS12345	COG0625	glutathione transferase activity
IS499_RS12380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS499_RS12385	COG3842	ATPase activity
IS499_RS12390	COG1840	ABC-type Fe3 transport system, periplasmic component
IS499_RS12395	COG1178	ABC-type Fe3 transport system permease component
IS499_RS12400	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IS499_RS12405	COG2181	nitrate reductase activity
IS499_RS12410	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS499_RS12415	COG1140	nitrate reductase beta subunit
IS499_RS12420	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS499_RS12440	COG1414	Transcriptional regulator
IS499_RS12445	COG4948	Mandelate Racemase Muconate Lactonizing
IS499_RS12450	COG4829	muconolactone delta-isomerase
IS499_RS12455	COG3485	protocatechuate 3,4-dioxygenase
IS499_RS12465	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IS499_RS12490	COG0437	4 iron, 4 sulfur cluster binding
IS499_RS12495	COG2864	formate dehydrogenase
IS499_RS12510	COG2326	polyphosphate kinase activity
IS499_RS12520	COG2814	Major facilitator Superfamily
IS499_RS12530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS499_RS12540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS499_RS12550	COG0747	negative chemotaxis
IS499_RS12555	COG1064	alcohol dehydrogenase
IS499_RS12570	COG0488	(ABC) transporter
IS499_RS12615	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS12620	COG3729	General stress protein
IS499_RS12630	COG3685	Protein conserved in bacteria
IS499_RS12640	COG0366	Alpha amylase catalytic
IS499_RS12650	COG2323	membrane
IS499_RS12660	COG3111	PFAM Bacterial OB fold (BOF) protein
IS499_RS12670	COG1764	response to oxidative stress
IS499_RS12695	COG3781	membrane
IS499_RS12700	COG0243	molybdopterin cofactor binding
IS499_RS12705	COG0583	DNA-binding transcription factor activity
IS499_RS12710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS12735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS12740	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS499_RS12745	COG2814	Major facilitator Superfamily
IS499_RS12750	COG1285	pathogenesis
IS499_RS12755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS499_RS12765	COG0583	DNA-binding transcription factor activity
IS499_RS12785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS499_RS12785	COG0519	Catalyzes the synthesis of GMP from XMP
IS499_RS12825	COG0596	Alpha beta hydrolase
IS499_RS12835	COG2205	protein histidine kinase activity
IS499_RS12850	COG0076	glutamate decarboxylase activity
IS499_RS12855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS499_RS12860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS499_RS12865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS499_RS12870	COG1116	anion transmembrane transporter activity
IS499_RS12875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IS499_RS12890	COG0673	inositol 2-dehydrogenase activity
IS499_RS12900	COG1609	Transcriptional regulator
IS499_RS12905	COG3706	GGDEF domain
IS499_RS12910	COG0402	S-adenosylhomocysteine deaminase activity
IS499_RS12915	COG1953	Uracil, thiamine, allantoin
IS499_RS12955	COG0406	alpha-ribazole phosphatase activity
IS499_RS12960	COG1335	isochorismatase
IS499_RS12990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS499_RS13060	COG0765	amino acid transport
IS499_RS13070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IS499_RS13080	COG2070	2-Nitropropane dioxygenase
IS499_RS13085	COG0583	DNA-binding transcription factor activity
IS499_RS13095	COG1902	pentaerythritol trinitrate reductase activity
IS499_RS13100	COG4529	Protein conserved in bacteria
IS499_RS13105	COG0477	Major facilitator Superfamily
IS499_RS13135	COG2223	nitrite transmembrane transporter activity
IS499_RS13145	COG1609	Transcriptional regulator
IS499_RS13150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS13160	COG3037	sugar-specific permease SgaT UlaA
IS499_RS13165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS499_RS13175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS499_RS13180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS499_RS13180	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS499_RS13180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS499_RS13195	COG0583	DNA-binding transcription factor activity
IS499_RS13200	COG0583	DNA-binding transcription factor activity
IS499_RS13205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS499_RS13215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS499_RS13230	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS13240	COG1609	Transcriptional regulator
IS499_RS13270	COG1652	LysM domain
IS499_RS13285	COG0426	domain, Protein
IS499_RS13285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS499_RS13310	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IS499_RS13310	COG0456	acetyltransferase
IS499_RS13320	COG0667	Aldo Keto reductase
IS499_RS13325	COG0667	Aldo Keto reductase
IS499_RS13335	COG0667	Aldo Keto reductase
IS499_RS13355	COG4977	sequence-specific DNA binding
IS499_RS13375	COG4977	sequence-specific DNA binding
IS499_RS13380	COG1349	DNA-binding transcription factor activity
IS499_RS13395	COG1349	DNA-binding transcription factor activity
IS499_RS13400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS499_RS13405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS13410	COG0738	Major facilitator superfamily
IS499_RS13455	COG1929	Belongs to the glycerate kinase type-1 family
IS499_RS13460	COG3835	regulator
IS499_RS13480	COG2186	Transcriptional regulator
IS499_RS13485	COG1263	PTS System
IS499_RS13485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS13495	COG2814	Major facilitator Superfamily
IS499_RS13500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS13500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS13515	COG2819	hydrolase of the alpha beta superfamily
IS499_RS13520	COG5001	Diguanylate cyclase
IS499_RS13520	COG3300	MHYT domain
IS499_RS13560	COG3188	usher protein
IS499_RS13570	COG1649	PFAM Uncharacterised BCR, COG1649
IS499_RS13575	COG3550	peptidyl-serine autophosphorylation
IS499_RS13580	COG1396	sequence-specific DNA binding
IS499_RS13585	COG2351	hydroxyisourate hydrolase activity
IS499_RS13590	COG3195	allantoin biosynthetic process
IS499_RS13590	COG3648	Uricase
IS499_RS13595	COG2233	PERMEase
IS499_RS13625	COG2207	Transcriptional regulator
IS499_RS13640	COG4628	conserved protein (DUF2132)
IS499_RS13660	COG2011	ABC-type metal ion transport system permease component
IS499_RS13665	COG2070	2-Nitropropane dioxygenase
IS499_RS13675	COG0477	Major facilitator Superfamily
IS499_RS13745	COG2199	diguanylate cyclase activity
IS499_RS13760	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS13765	COG0583	DNA-binding transcription factor activity
IS499_RS13775	COG0039	L-malate dehydrogenase activity
IS499_RS13780	COG1349	DNA-binding transcription factor activity
IS499_RS13785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS499_RS13790	COG3395	kinase activity
IS499_RS13800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS499_RS13815	COG2731	YhcH YjgK YiaL family protein
IS499_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS13850	COG4977	sequence-specific DNA binding
IS499_RS13860	COG0697	spore germination
IS499_RS13865	COG2814	Major facilitator Superfamily
IS499_RS13875	COG0410	ABC transporter
IS499_RS13880	COG1129	ABC transporter
IS499_RS13895	COG0683	leucine binding
IS499_RS13900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IS499_RS13935	COG2223	nitrite transmembrane transporter activity
IS499_RS13940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IS499_RS13955	COG1349	DNA-binding transcription factor activity
IS499_RS13960	COG2084	Dehydrogenase
IS499_RS13965	COG3395	kinase activity
IS499_RS13970	COG0235	Class ii aldolase
IS499_RS13975	COG3622	Belongs to the hyi family
IS499_RS13980	COG2610	gluconate transmembrane transporter activity
IS499_RS13985	COG2207	Transcriptional regulator
IS499_RS13985	COG3708	Transcriptional regulator
IS499_RS14000	COG2200	EAL domain
IS499_RS14005	COG1546	Belongs to the CinA family
IS499_RS14010	COG0071	Belongs to the small heat shock protein (HSP20) family
IS499_RS14025	COG2197	response regulator
IS499_RS14040	COG2135	peptidase activity
IS499_RS14045	COG2207	Transcriptional regulator
IS499_RS14060	COG4221	oxidoreductase activity
IS499_RS14065	COG1802	Transcriptional regulator
IS499_RS14070	COG0589	response to stress
IS499_RS14075	COG0246	Mannitol dehydrogenase
IS499_RS14080	COG2271	Major facilitator Superfamily
IS499_RS14095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS499_RS14110	COG0243	molybdopterin cofactor binding
IS499_RS14115	COG0437	4 iron, 4 sulfur cluster binding
IS499_RS14120	COG3302	dmso reductase anchor subunit
IS499_RS14135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IS499_RS14140	COG1940	carbohydrate kinase activity
IS499_RS14145	COG0583	DNA-binding transcription factor activity
IS499_RS14150	COG2814	Major facilitator Superfamily
IS499_RS14155	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IS499_RS14165	COG3591	Belongs to the peptidase S1B family
IS499_RS14185	COG0628	permease
IS499_RS14215	COG0679	Auxin Efflux Carrier
IS499_RS14225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS499_RS14250	COG3290	protein histidine kinase activity
IS499_RS14255	COG4565	transcriptional regulatory protein
IS499_RS14275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS499_RS14275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS499_RS14285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS499_RS14290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS499_RS14300	COG0183	Belongs to the thiolase family
IS499_RS14305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS499_RS14315	COG1414	Transcriptional regulator
IS499_RS14320	COG2840	Smr protein MutS2
IS499_RS14325	COG0583	DNA-binding transcription factor activity
IS499_RS14335	COG1473	amidohydrolase
IS499_RS14340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IS499_RS14355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS499_RS14370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IS499_RS14375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IS499_RS14390	COG0531	amino acid
IS499_RS14400	COG3136	membrane protein required for alginate biosynthesis
IS499_RS14405	COG0745	RESPONSE REGULATOR receiver
IS499_RS14415	COG2205	protein histidine kinase activity
IS499_RS14425	COG0114	fumarate hydratase activity
IS499_RS14430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS499_RS14430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS499_RS14435	COG1482	cell wall glycoprotein biosynthetic process
IS499_RS14440	COG5339	Protein conserved in bacteria
IS499_RS14445	COG1609	Transcriptional regulator
IS499_RS14450	COG1263	PTS System
IS499_RS14450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS14455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS499_RS14480	COG2391	methyltransferase activity
IS499_RS14485	COG0425	Belongs to the sulfur carrier protein TusA family
IS499_RS14490	COG5562	phage envelope protein
IS499_RS14495	COG0401	homolog of Blt101
IS499_RS14500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS499_RS14505	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS14515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS499_RS14520	COG0477	Major facilitator Superfamily
IS499_RS14525	COG1113	amino acid transport
IS499_RS14530	COG2988	succinylglutamate desuccinylase activity
IS499_RS14535	COG3724	N-succinylarginine dihydrolase activity
IS499_RS14540	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS14545	COG3138	arginine N-succinyltransferase
IS499_RS14550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS499_RS14560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS499_RS14565	COG0667	Aldo Keto reductase
IS499_RS14570	COG0583	DNA-binding transcription factor activity
IS499_RS14595	COG4122	O-methyltransferase activity
IS499_RS14600	COG1643	Atp-dependent helicase
IS499_RS14615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS499_RS14620	COG3327	negative regulation of DNA-templated transcription, initiation
IS499_RS14625	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IS499_RS14630	COG0183	Belongs to the thiolase family
IS499_RS14635	COG2050	protein possibly involved in aromatic compounds catabolism
IS499_RS14640	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS499_RS14645	COG1024	Enoyl-CoA hydratase
IS499_RS14650	COG1024	Enoyl-CoA hydratase
IS499_RS14655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS499_RS14660	COG2151	metal-sulfur cluster biosynthetic enzyme
IS499_RS14665	COG3396	Phenylacetate-CoA oxygenase
IS499_RS14670	COG3460	Phenylacetate-CoA oxygenase
IS499_RS14675	COG3396	Phenylacetate-CoA oxygenase
IS499_RS14680	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS14680	COG2030	dehydratase
IS499_RS14700	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS14705	COG2207	Transcriptional regulator
IS499_RS14710	COG3784	Protein of unknown function (DUF1318)
IS499_RS14720	COG2911	Protein conserved in bacteria
IS499_RS14725	COG0586	Pfam SNARE associated Golgi protein
IS499_RS14730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS499_RS14735	COG3187	Heat shock protein
IS499_RS14740	COG3042	response to heat
IS499_RS14745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS499_RS14745	COG1013	pyruvate-flavodoxin oxidoreductase activity
IS499_RS14745	COG0674	pyruvate-flavodoxin oxidoreductase activity
IS499_RS14745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IS499_RS14750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS499_RS14760	COG0589	response to stress
IS499_RS14770	COG0513	Belongs to the DEAD box helicase family
IS499_RS14780	COG1349	DNA-binding transcription factor activity
IS499_RS14785	COG0673	inositol 2-dehydrogenase activity
IS499_RS14800	COG1113	amino acid transport
IS499_RS14805	COG1522	sequence-specific DNA binding
IS499_RS14815	COG1448	Aminotransferase
IS499_RS14820	COG2011	ABC-type metal ion transport system permease component
IS499_RS14835	COG0436	Aminotransferase
IS499_RS14840	COG0604	alcohol dehydrogenase
IS499_RS14870	COG0583	DNA-binding transcription factor activity
IS499_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS14895	COG1309	transcriptional regulator
IS499_RS14900	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS14995	COG2885	chlorophyll binding
IS499_RS15035	COG3344	reverse transcriptase
IS499_RS15120	COG1196	nuclear chromosome segregation
IS499_RS15120	COG0741	lytic transglycosylase activity
IS499_RS15120	COG0739	heme binding
IS499_RS15190	COG3567	Phage-associated protein, HI1409 family
IS499_RS15195	COG1783	phage Terminase large subunit
IS499_RS15215	COG3772	lysozyme
IS499_RS15225	COG0484	heat shock protein binding
IS499_RS15330	COG0582	viral genome integration into host DNA
IS499_RS15335	COG0693	protein deglycase activity
IS499_RS15340	COG1078	dGTPase activity
IS499_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS15350	COG0583	DNA-binding transcription factor activity
IS499_RS15370	COG0656	L-ascorbic acid biosynthetic process
IS499_RS15400	COG4166	transmembrane transport
IS499_RS15410	COG2866	Carboxypeptidase
IS499_RS15415	COG4948	Mandelate Racemase Muconate Lactonizing
IS499_RS15420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IS499_RS15425	COG3180	Ammonia monooxygenase
IS499_RS15435	COG1486	melibiose metabolic process
IS499_RS15440	COG0583	DNA-binding transcription factor activity
IS499_RS15450	COG3106	COG3106 Predicted ATPase
IS499_RS15460	COG1983	PspC domain protein
IS499_RS15470	COG1842	Phage shock protein A
IS499_RS15475	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS499_RS15485	COG1473	amidohydrolase
IS499_RS15500	COG0702	epimerase
IS499_RS15515	COG2135	peptidase activity
IS499_RS15525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS499_RS15530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS499_RS15535	COG3344	reverse transcriptase
IS499_RS15580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IS499_RS15695	COG4171	peptide transport system, permease
IS499_RS15710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS499_RS15720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS499_RS15725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS499_RS15725	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS499_RS15740	COG1349	DNA-binding transcription factor activity
IS499_RS15750	COG0023	Translation Initiation Factor
IS499_RS15760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IS499_RS15765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IS499_RS15770	COG0671	phosphoesterase, PA-phosphatase related
IS499_RS15780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IS499_RS15805	COG0616	signal peptide processing
IS499_RS15815	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS15820	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IS499_RS15830	COG0583	DNA-binding transcription factor activity
IS499_RS15840	COG0009	L-threonylcarbamoyladenylate synthase
IS499_RS15850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IS499_RS15855	COG0512	Glutamine amidotransferase of anthranilate synthase
IS499_RS15855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS499_RS15860	COG0135	phosphoribosylanthranilate isomerase activity
IS499_RS15860	COG0134	indole-3-glycerol-phosphate synthase activity
IS499_RS15915	COG4774	siderophore transport
IS499_RS15925	COG3047	cAMP biosynthetic process
IS499_RS15930	COG0727	PFAM Uncharacterised protein family (UPF0153)
IS499_RS15960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS499_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS15970	COG1988	membrane-bound metal-dependent
IS499_RS15975	COG1823	symporter activity
IS499_RS15985	COG0753	catalase activity
IS499_RS15995	COG1486	melibiose metabolic process
IS499_RS16000	COG1917	Cupin 2, conserved barrel domain protein
IS499_RS16000	COG2169	Transcriptional regulator
IS499_RS16005	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS499_RS16010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS16020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS16025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS499_RS16035	COG0322	excinuclease ABC activity
IS499_RS16040	COG3678	ATP-independent chaperone mediated protein folding
IS499_RS16050	COG3724	N-succinylarginine dihydrolase activity
IS499_RS16060	COG3138	arginine N-succinyltransferase
IS499_RS16070	COG0708	Exodeoxyribonuclease III
IS499_RS16075	COG0398	Pfam SNARE associated Golgi protein
IS499_RS16080	COG0398	Pfam SNARE associated Golgi protein
IS499_RS16085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS499_RS16090	COG4134	Bacterial extracellular solute-binding protein
IS499_RS16095	COG4135	transport system, permease component
IS499_RS16100	COG4136	ATPase activity
IS499_RS16105	COG2897	thiosulfate sulfurtransferase activity
IS499_RS16110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS499_RS16115	COG0494	nUDIX hydrolase
IS499_RS16120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS499_RS16125	COG0604	alcohol dehydrogenase
IS499_RS16125	COG3321	synthase
IS499_RS16125	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS16130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS499_RS16135	COG0709	Synthesizes selenophosphate from selenide and ATP
IS499_RS16150	COG0778	Nitroreductase
IS499_RS16155	COG0616	signal peptide processing
IS499_RS16160	COG0252	asparaginase activity
IS499_RS16165	COG1335	isochorismatase
IS499_RS16170	COG2814	Major facilitator Superfamily
IS499_RS16175	COG1349	DNA-binding transcription factor activity
IS499_RS16180	COG0667	Aldo Keto reductase
IS499_RS16185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS16190	COG0191	fructose-bisphosphate aldolase activity
IS499_RS16195	COG1063	alcohol dehydrogenase
IS499_RS16200	COG2271	Major facilitator Superfamily
IS499_RS16205	COG1063	alcohol dehydrogenase
IS499_RS16220	COG3139	Protein of unknown function (DUF1315)
IS499_RS16245	COG3713	MltA-interacting MipA family protein
IS499_RS16250	COG2766	serine protein kinase
IS499_RS16265	COG0386	Belongs to the glutathione peroxidase family
IS499_RS16290	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS16295	COG0583	DNA-binding transcription factor activity
IS499_RS16300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS499_RS16305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS499_RS16310	COG3344	reverse transcriptase
IS499_RS16320	COG0859	PFAM glycosyl transferase family 9
IS499_RS16325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS499_RS16335	COG2207	Transcriptional regulator
IS499_RS16340	COG2807	transmembrane transport
IS499_RS16345	COG0504	CTP synthase activity
IS499_RS16350	COG1683	Conserved Protein
IS499_RS16355	COG3189	MarR family transcriptional regulator
IS499_RS16360	COG3042	response to heat
IS499_RS16365	COG2199	diguanylate cyclase activity
IS499_RS16365	COG2203	Gaf domain
IS499_RS16385	COG3182	Iron-regulated membrane protein
IS499_RS16395	COG1560	Kdo2-lipid A biosynthetic process
IS499_RS16405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IS499_RS16410	COG3706	GGDEF domain
IS499_RS16415	COG0583	DNA-binding transcription factor activity
IS499_RS16420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS499_RS16450	COG1294	oxidase, subunit
IS499_RS16455	COG1271	oxidase subunit
IS499_RS16460	COG3546	catalase activity
IS499_RS16465	COG3685	Protein conserved in bacteria
IS499_RS16470	COG3685	Protein conserved in bacteria
IS499_RS16475	COG3729	General stress protein
IS499_RS16480	COG1063	alcohol dehydrogenase
IS499_RS16485	COG3813	Protein conserved in bacteria
IS499_RS16505	COG0640	Transcriptional regulator
IS499_RS16510	COG0538	isocitrate dehydrogenase activity
IS499_RS16595	COG0616	signal peptide processing
IS499_RS16610	COG4626	Terminase
IS499_RS16610	COG1802	Transcriptional regulator
IS499_RS16655	COG3772	lysozyme
IS499_RS16680	COG1403	HNH endonuclease
IS499_RS16700	COG3344	reverse transcriptase
IS499_RS16705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IS499_RS16715	COG3344	reverse transcriptase
IS499_RS16750	COG1396	sequence-specific DNA binding
IS499_RS16770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS499_RS16780	COG0582	viral genome integration into host DNA
IS499_RS16785	COG0538	isocitrate dehydrogenase activity
IS499_RS16805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS499_RS16810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS499_RS16815	COG3344	reverse transcriptase
IS499_RS16865	COG1196	nuclear chromosome segregation
IS499_RS16905	COG0740	serine-type endopeptidase activity
IS499_RS16980	COG1403	HNH endonuclease
IS499_RS16985	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IS499_RS17015	COG1396	sequence-specific DNA binding
IS499_RS17070	COG0582	viral genome integration into host DNA
IS499_RS17075	COG0538	isocitrate dehydrogenase activity
IS499_RS17080	COG1187	pseudouridine synthase activity
IS499_RS17100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IS499_RS17120	COG2205	protein histidine kinase activity
IS499_RS17125	COG2850	peptidyl-arginine hydroxylation
IS499_RS17145	COG1177	transmembrane transport
IS499_RS17160	COG0318	PFAM AMP-dependent synthetase and ligase
IS499_RS17170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IS499_RS17180	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS499_RS17190	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS499_RS17200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IS499_RS17205	COG1388	LysM domain
IS499_RS17205	COG1376	ErfK ybiS ycfS ynhG family protein
IS499_RS17220	COG1309	transcriptional regulator
IS499_RS17235	COG3134	Outer membrane lipoprotein
IS499_RS17240	COG1252	NADH dehydrogenase
IS499_RS17265	COG5633	Lipoprotein
IS499_RS17270	COG0537	adenosine 5'-monophosphoramidase activity
IS499_RS17280	COG0084	hydrolase, TatD family'
IS499_RS17285	COG0470	DNA polymerase III
IS499_RS17295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IS499_RS17300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS499_RS17305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS499_RS17320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS499_RS17340	COG1399	metal-binding, possibly nucleic acid-binding protein
IS499_RS17360	COG1530	ribonuclease E activity
IS499_RS17365	COG0583	DNA-binding transcription factor activity
IS499_RS17370	COG2814	Major facilitator Superfamily
IS499_RS17390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS499_RS17435	COG1560	Kdo2-lipid A biosynthetic process
IS499_RS17450	COG5645	(Lipo)protein
IS499_RS17485	COG3381	protein complex oligomerization
IS499_RS17515	COG0583	DNA-binding transcription factor activity
IS499_RS17525	COG1335	isochorismatase
IS499_RS17535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS499_RS17540	COG1702	phosphate starvation-inducible protein PhoH
IS499_RS17560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS499_RS17570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS499_RS17585	COG1309	transcriptional regulator
IS499_RS17620	COG2233	PERMEase
IS499_RS17630	COG3729	General stress protein
IS499_RS17660	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS17675	COG0531	amino acid
IS499_RS17680	COG0174	glutamine synthetase
IS499_RS17685	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IS499_RS17690	COG1396	sequence-specific DNA binding
IS499_RS17690	COG1917	Cupin 2, conserved barrel domain protein
IS499_RS17695	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS17700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS499_RS17705	COG0583	DNA-binding transcription factor activity
IS499_RS17710	COG0473	3-isopropylmalate dehydrogenase activity
IS499_RS17715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS499_RS17720	COG4638	Rieske (2fe-2S)
IS499_RS17725	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS17730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS499_RS17760	COG0670	Belongs to the BI1 family
IS499_RS17775	COG2207	Transcriptional regulator
IS499_RS17780	COG1881	PFAM PEBP family protein
IS499_RS17795	COG1832	CoA-binding protein
IS499_RS17805	COG0210	DNA helicase
IS499_RS17810	COG3304	Inner membrane component domain
IS499_RS17815	COG1289	transmembrane transporter activity
IS499_RS17820	COG3070	regulator of competence-specific genes
IS499_RS17840	COG1067	ATP-dependent peptidase activity
IS499_RS17850	COG3130	regulation of translation
IS499_RS17855	COG3009	Protein conserved in bacteria
IS499_RS17860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS499_RS17860	COG3008	intermembrane lipid transfer
IS499_RS17865	COG2995	paraquat-inducible protein a
IS499_RS17870	COG0488	(ABC) transporter
IS499_RS17880	COG0633	Ferredoxin
IS499_RS17880	COG3217	Mosc domain protein beta barrel domain protein
IS499_RS17895	COG0431	NADPH-dependent FMN reductase
IS499_RS17900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS499_RS17905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS499_RS17910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS499_RS17920	COG0308	aminopeptidase N
IS499_RS17930	COG1473	amidohydrolase
IS499_RS17940	COG0814	amino acid
IS499_RS17965	COG1448	Aminotransferase
IS499_RS17970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS499_RS17975	COG3108	Peptidase M15
IS499_RS17980	COG2989	Protein conserved in bacteria
IS499_RS17990	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IS499_RS18000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS499_RS18005	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS499_RS18010	COG3173	Aminoglycoside phosphotransferase
IS499_RS18025	COG3214	Protein conserved in bacteria
IS499_RS18040	COG2333	competence protein COMEC
IS499_RS18040	COG0658	competence protein
IS499_RS18050	COG0539	negative regulation of cytoplasmic translation
IS499_RS18070	COG2323	membrane
IS499_RS18075	COG1944	ATP diphosphatase activity
IS499_RS18080	COG2116	formate transmembrane transporter activity
IS499_RS18085	COG1882	Formate acetyltransferase
IS499_RS18090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS499_RS18095	COG0477	Major facilitator Superfamily
IS499_RS18100	COG3302	dmso reductase anchor subunit
IS499_RS18105	COG0437	4 iron, 4 sulfur cluster binding
IS499_RS18110	COG0243	molybdopterin cofactor binding
IS499_RS18120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IS499_RS18130	COG1674	ftsk spoiiie
IS499_RS18130	COG1178	ABC-type Fe3 transport system permease component
IS499_RS18140	COG0492	ferredoxin-NADP+ reductase activity
IS499_RS18145	COG4988	ABC transporter
IS499_RS18150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IS499_RS18165	COG0542	response to heat
IS499_RS18175	COG1278	Cold shock
IS499_RS18185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS18190	COG3593	DNA synthesis involved in DNA repair
IS499_RS18200	COG2431	L-lysine efflux transmembrane transporter activity
IS499_RS18210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS499_RS18220	COG0028	Belongs to the TPP enzyme family
IS499_RS18225	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IS499_RS18230	COG0702	epimerase
IS499_RS18235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS499_RS18240	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS499_RS18245	COG3706	GGDEF domain
IS499_RS18245	COG4251	negative regulation of phosphorylation
IS499_RS18245	COG5001	Diguanylate cyclase
IS499_RS18245	COG2203	Gaf domain
IS499_RS18255	COG1126	abc transporter atp-binding protein
IS499_RS18260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS18265	COG4215	(ABC) transporter
IS499_RS18270	COG4160	amino acid transport
IS499_RS18275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS18280	COG5002	protein histidine kinase activity
IS499_RS18285	COG0745	RESPONSE REGULATOR receiver
IS499_RS18300	COG1177	transmembrane transport
IS499_RS18305	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS499_RS18310	COG3842	ATPase activity
IS499_RS18315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS499_RS18510	COG4695	Portal protein
IS499_RS18545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS499_RS18585	COG3344	reverse transcriptase
IS499_RS18590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS499_RS18595	COG3226	Transcriptional regulator
IS499_RS18600	COG0738	Major facilitator superfamily
IS499_RS18605	COG0561	phosphatase activity
IS499_RS18610	COG2814	Major facilitator Superfamily
IS499_RS18615	COG0671	phosphoesterase, PA-phosphatase related
IS499_RS18620	COG1349	DNA-binding transcription factor activity
IS499_RS18625	COG1686	Belongs to the peptidase S11 family
IS499_RS18635	COG0625	glutathione transferase activity
IS499_RS18640	COG2133	pyrroloquinoline quinone binding
IS499_RS18650	COG2223	nitrite transmembrane transporter activity
IS499_RS18670	COG0747	negative chemotaxis
IS499_RS18685	COG0303	'Molybdopterin
IS499_RS18690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS499_RS18695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS499_RS18700	COG1882	Formate acetyltransferase
IS499_RS18705	COG0561	phosphatase activity
IS499_RS18715	COG1609	Transcriptional regulator
IS499_RS18720	COG2271	Major facilitator Superfamily
IS499_RS18730	COG0488	(ABC) transporter
IS499_RS18735	COG2365	Tyrosine phosphatase family
IS499_RS18740	COG1376	ErfK ybiS ycfS ynhG family protein
IS499_RS18745	COG2188	Transcriptional regulator
IS499_RS18750	COG2723	6-phospho-beta-galactosidase activity
IS499_RS18755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS499_RS18760	COG1321	iron dependent repressor
IS499_RS18770	COG2194	sulfuric ester hydrolase activity
IS499_RS18775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IS499_RS18790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS18795	COG0765	amino acid transport
IS499_RS18800	COG1126	abc transporter atp-binding protein
IS499_RS18805	COG0668	transmembrane transport
IS499_RS18815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS499_RS18825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS499_RS18835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS499_RS18840	COG1199	ATP-dependent helicase activity
IS499_RS18845	COG0513	Belongs to the DEAD box helicase family
IS499_RS18850	COG3958	Transketolase
IS499_RS18855	COG3959	Transketolase, thiamine diphosphate binding domain
IS499_RS18860	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS18865	COG2271	Major facilitator Superfamily
IS499_RS18875	COG0583	DNA-binding transcription factor activity
IS499_RS18880	COG1309	transcriptional regulator
IS499_RS18885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS18890	COG1131	(ABC) transporter
IS499_RS18895	COG0842	Transport permease protein
IS499_RS18900	COG0842	Transport permease protein
IS499_RS18910	COG3568	Endonuclease Exonuclease Phosphatase
IS499_RS18915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS499_RS18920	COG0392	lysyltransferase activity
IS499_RS18925	COG0670	Belongs to the BI1 family
IS499_RS18930	COG0314	molybdopterin synthase activity
IS499_RS18935	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IS499_RS18945	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS499_RS18965	COG0745	RESPONSE REGULATOR receiver
IS499_RS18970	COG0642	Histidine kinase
IS499_RS18995	COG2226	methyltransferase
IS499_RS19010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS499_RS19015	COG1881	PFAM PEBP family protein
IS499_RS19055	COG4677	pectinesterase activity
IS499_RS19090	COG0789	Transcriptional regulator
IS499_RS19095	COG2200	EAL domain
IS499_RS19120	COG0561	phosphatase activity
IS499_RS19125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IS499_RS19130	COG4149	molybdate abc transporter
IS499_RS19135	COG0725	ABC transporter, periplasmic molybdate-binding protein
IS499_RS19145	COG2005	Transcriptional regulator
IS499_RS19145	COG3585	molybdate ion transport
IS499_RS19150	COG1119	ATPase activity
IS499_RS19160	COG1085	galactose-1-phosphate uridylyltransferase
IS499_RS19170	COG2017	converts alpha-aldose to the beta-anomer
IS499_RS19180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS499_RS19195	COG3201	nicotinamide mononucleotide transporter
IS499_RS19200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IS499_RS19240	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IS499_RS19245	COG2885	chlorophyll binding
IS499_RS19255	COG3064	Membrane
IS499_RS19260	COG0848	biopolymer transport protein
IS499_RS19265	COG0811	peptide transport
IS499_RS19270	COG0824	Thioesterase
IS499_RS19275	COG3790	cyd operon protein YbgE
IS499_RS19280	COG4890	Cyd operon protein YbgT
IS499_RS19285	COG1294	oxidase, subunit
IS499_RS19290	COG1271	oxidase subunit
IS499_RS19295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS499_RS19305	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS499_RS19310	COG0567	Dehydrogenase, E1 component
IS499_RS19315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS499_RS19320	COG1053	succinate dehydrogenase
IS499_RS19325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IS499_RS19330	COG2009	succinate dehydrogenase
IS499_RS19365	COG1984	allophanate hydrolase subunit 2
IS499_RS19370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IS499_RS19385	COG0415	Belongs to the DNA photolyase family
IS499_RS19415	COG2205	protein histidine kinase activity
IS499_RS19420	COG0745	RESPONSE REGULATOR receiver
IS499_RS19430	COG0033	Phosphoglucomutase
IS499_RS19440	COG0596	Alpha beta hydrolase
IS499_RS19455	COG0735	belongs to the Fur family
IS499_RS19495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IS499_RS19500	COG1940	carbohydrate kinase activity
IS499_RS19500	COG1846	Transcriptional regulator
IS499_RS19505	COG0647	UMP catabolic process
IS499_RS19510	COG0367	asparagine synthase
IS499_RS19550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS499_RS19560	COG1702	phosphate starvation-inducible protein PhoH
IS499_RS19570	COG4535	Mg2 and Co2 transporter CorC
IS499_RS19585	COG0765	amino acid transport
IS499_RS19590	COG0765	amino acid transport
IS499_RS19595	COG1126	abc transporter atp-binding protein
IS499_RS19610	COG2888	peptidyl-tyrosine sulfation
IS499_RS19625	COG1466	dna polymerase III delta subunit
IS499_RS19640	COG0799	negative regulation of ribosome biogenesis
IS499_RS19650	COG0768	penicillin binding
IS499_RS19655	COG0772	Belongs to the SEDS family
IS499_RS19660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS499_RS19665	COG1686	Belongs to the peptidase S11 family
IS499_RS19680	COG0583	DNA-binding transcription factor activity
IS499_RS19695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS499_RS19715	COG3069	C4-dicarboxylate transmembrane transporter activity
IS499_RS19720	COG3719	Belongs to the RNase T2 family
IS499_RS19725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS499_RS19745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS499_RS19750	COG0583	DNA-binding transcription factor activity
IS499_RS19755	COG3969	phosphoadenosine phosphosulfate
IS499_RS19760	COG1475	DNA binding
IS499_RS19765	COG0436	Aminotransferase
IS499_RS19790	COG1129	ABC transporter
IS499_RS19795	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS19800	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS19810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS499_RS19825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS499_RS19835	COG0402	S-adenosylhomocysteine deaminase activity
IS499_RS19845	COG0483	inositol monophosphate 1-phosphatase activity
IS499_RS19850	COG2271	Major facilitator Superfamily
IS499_RS19880	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS19885	COG1129	ABC transporter
IS499_RS19890	COG0371	Dehydrogenase
IS499_RS19895	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS19910	COG2879	small protein
IS499_RS19915	COG1966	Carbon starvation protein
IS499_RS19925	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS19930	COG1535	isochorismatase
IS499_RS19930	COG3433	isochorismatase activity
IS499_RS19935	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS499_RS19940	COG1169	isochorismate synthase
IS499_RS19945	COG4592	Periplasmic binding protein
IS499_RS19955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS19960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS19965	COG1120	ATPase activity
IS499_RS19970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS499_RS19970	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IS499_RS19975	COG3251	PFAM MbtH domain protein
IS499_RS19980	COG2382	esterase
IS499_RS19985	COG4771	TonB-dependent receptor
IS499_RS19990	COG2977	Belongs to the P-Pant transferase superfamily
IS499_RS19995	COG3958	Transketolase
IS499_RS20000	COG3959	Transketolase, thiamine diphosphate binding domain
IS499_RS20005	COG2390	Transcriptional regulator
IS499_RS20010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS499_RS20015	COG1879	ABC-type sugar transport system periplasmic component
IS499_RS20025	COG1129	ABC transporter
IS499_RS20030	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS20040	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS20050	COG0583	DNA-binding transcription factor activity
IS499_RS20055	COG0668	transmembrane transport
IS499_RS20065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS499_RS20090	COG0747	negative chemotaxis
IS499_RS20095	COG0601	transmembrane transport
IS499_RS20100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS499_RS20105	COG0444	Belongs to the ABC transporter superfamily
IS499_RS20110	COG4608	Belongs to the ABC transporter superfamily
IS499_RS20115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS499_RS20120	COG4221	oxidoreductase activity
IS499_RS20130	COG4215	(ABC) transporter
IS499_RS20135	COG0765	amino acid transport
IS499_RS20140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IS499_RS20155	COG0697	spore germination
IS499_RS20165	COG3698	Phosphodiester glycosidase
IS499_RS20210	COG2315	Protein conserved in bacteria
IS499_RS20215	COG0778	Nitroreductase
IS499_RS20225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS20235	COG3716	PTS system mannose fructose sorbose family IID component
IS499_RS20240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS499_RS20245	COG2222	sugar isomerase
IS499_RS20250	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS499_RS20250	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS499_RS20265	COG0477	Major facilitator Superfamily
IS499_RS20270	COG0668	transmembrane transport
IS499_RS20300	COG3188	usher protein
IS499_RS20315	COG2771	luxR family
IS499_RS20325	COG0673	inositol 2-dehydrogenase activity
IS499_RS20335	COG2211	Major facilitator Superfamily
IS499_RS20340	COG1113	amino acid transport
IS499_RS20355	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS20360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS499_RS20370	COG0531	amino acid
IS499_RS20415	COG0667	Aldo Keto reductase
IS499_RS20420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS20425	COG1473	amidohydrolase
IS499_RS20455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS20460	COG1120	ATPase activity
IS499_RS20465	COG1566	PFAM secretion protein HlyD family protein
IS499_RS20510	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS20515	COG1129	ABC transporter
IS499_RS20530	COG0673	inositol 2-dehydrogenase activity
IS499_RS20560	COG3104	oligopeptide transport
IS499_RS20565	COG1982	Orn Lys Arg decarboxylase major
IS499_RS20570	COG0531	amino acid
IS499_RS20575	COG3710	Transcriptional regulator
IS499_RS20585	COG1560	Kdo2-lipid A biosynthetic process
IS499_RS20600	COG3188	usher protein
IS499_RS20605	COG3121	Chaperone
IS499_RS20610	COG3539	Fimbrial protein
IS499_RS20660	COG2501	S4 domain
IS499_RS20670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS499_RS20685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IS499_RS20690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IS499_RS20710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IS499_RS20715	COG4181	ATPase activity
IS499_RS20720	COG2755	lipolytic protein G-D-S-L family
IS499_RS20725	COG0300	oxidoreductase activity
IS499_RS20730	COG3118	belongs to the thioredoxin family
IS499_RS20735	COG0390	transport system, permease component
IS499_RS20740	COG4619	ABC transporter
IS499_RS20745	COG0330	HflC and HflK could
IS499_RS20750	COG1585	Membrane protein implicated in regulation of membrane protease activity
IS499_RS20765	COG3735	TraB family
IS499_RS20770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS499_RS20780	COG2223	nitrite transmembrane transporter activity
IS499_RS20785	COG4651	solute:proton antiporter activity
IS499_RS20785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS499_RS20790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS20830	COG2832	Protein of unknown function (DUF454)
IS499_RS20835	COG3923	Primosomal replication protein n
IS499_RS20845	COG5464	transposase or invertase
IS499_RS20850	COG3264	Mechanosensitive ion channel
IS499_RS20850	COG1196	nuclear chromosome segregation
IS499_RS20870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS20875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS499_RS20890	COG0110	maltose O-acetyltransferase activity
IS499_RS20940	COG1874	Beta-galactosidase
IS499_RS20945	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IS499_RS20950	COG3833	ABC-type maltose transport systems, permease component
IS499_RS20955	COG1175	transmembrane transport
IS499_RS20960	COG2182	Extracellular solute-binding protein
IS499_RS20970	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS499_RS20985	COG2364	Membrane
IS499_RS21015	COG3695	enzyme binding
IS499_RS21020	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IS499_RS21025	COG1946	Acyl-CoA thioesterase
IS499_RS21030	COG0004	ammonium transporteR
IS499_RS21035	COG0347	Belongs to the P(II) protein family
IS499_RS21040	COG1132	(ABC) transporter
IS499_RS21045	COG1132	(ABC) transporter
IS499_RS21050	COG1522	sequence-specific DNA binding
IS499_RS21065	COG4533	DNA binding
IS499_RS21075	COG0824	Thioesterase
IS499_RS21080	COG1555	photosystem II stabilization
IS499_RS21085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS499_RS21090	COG0776	regulation of translation
IS499_RS21095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IS499_RS21115	COG0271	Belongs to the BolA IbaG family
IS499_RS21120	COG3056	Lipoprotein
IS499_RS21125	COG2223	nitrite transmembrane transporter activity
IS499_RS21130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS499_RS21135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS499_RS21140	COG1845	cytochrome c oxidase, subunit III
IS499_RS21145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IS499_RS21160	COG1414	Transcriptional regulator
IS499_RS21165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS499_RS21170	COG1053	succinate dehydrogenase
IS499_RS21180	COG1053	succinate dehydrogenase
IS499_RS21195	COG0673	inositol 2-dehydrogenase activity
IS499_RS21200	COG2814	Major facilitator Superfamily
IS499_RS21210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IS499_RS21215	COG0693	protein deglycase activity
IS499_RS21235	COG0142	geranyltranstransferase activity
IS499_RS21245	COG0667	Aldo Keto reductase
IS499_RS21250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IS499_RS21270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS499_RS21270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS499_RS21280	COG4238	major outer membrane lipoprotein
IS499_RS21300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS499_RS21305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS499_RS21310	COG1862	Preprotein translocase
IS499_RS21335	COG0450	alkyl hydroperoxide reductase
IS499_RS21345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS21360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS21370	COG1228	amidohydrolase
IS499_RS21380	COG1335	isochorismatase
IS499_RS21385	COG0583	DNA-binding transcription factor activity
IS499_RS21390	COG0366	Alpha amylase catalytic
IS499_RS21415	COG0420	3'-5' exonuclease activity
IS499_RS21420	COG0419	ATPase involved in DNA repair
IS499_RS21425	COG1940	carbohydrate kinase activity
IS499_RS21440	COG4126	flavin adenine dinucleotide binding
IS499_RS21450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS499_RS21455	COG3416	Protein conserved in bacteria
IS499_RS21465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IS499_RS21475	COG1785	Belongs to the alkaline phosphatase family
IS499_RS21515	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IS499_RS21520	COG1335	isochorismatase
IS499_RS21525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IS499_RS21530	COG0113	porphobilinogen synthase activity
IS499_RS21540	COG2175	clavaminate synthase activity
IS499_RS21545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS499_RS21550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IS499_RS21555	COG4521	taurine ABC transporter
IS499_RS21560	COG2040	homocysteine
IS499_RS21565	COG0833	amino acid
IS499_RS21580	COG4303	Ethanolamine ammonia lyase large subunit
IS499_RS21585	COG4302	ethanolamine ammonia-lyase activity
IS499_RS21625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS21630	COG1126	abc transporter atp-binding protein
IS499_RS21635	COG0765	amino acid transport
IS499_RS21640	COG0765	amino acid transport
IS499_RS21655	COG3188	usher protein
IS499_RS21680	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IS499_RS21690	COG3639	organic phosphonate transmembrane transporter activity
IS499_RS21710	COG0791	NLP P60 protein
IS499_RS21735	COG0582	viral genome integration into host DNA
IS499_RS21740	COG1192	Involved in chromosome partitioning
IS499_RS21800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IS499_RS21805	COG0022	dehydrogenase e1 component
IS499_RS21810	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS499_RS21815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS499_RS21835	COG1070	Carbohydrate kinase
IS499_RS21840	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS21845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS499_RS21850	COG3775	system Galactitol-specific IIC component
IS499_RS21855	COG0625	glutathione transferase activity
IS499_RS21860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IS499_RS21875	COG0579	oxidoreductase
IS499_RS21880	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS21885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS499_RS21890	COG1113	amino acid transport
IS499_RS21895	COG1802	Transcriptional regulator
IS499_RS21915	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS499_RS21920	COG0454	-acetyltransferase
IS499_RS21935	COG2991	Protein conserved in bacteria
IS499_RS21950	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS499_RS21955	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS499_RS21970	COG3034	peptidoglycan biosynthetic process
IS499_RS21975	COG0121	glutamine amidotransferase
IS499_RS21985	COG1960	acyl-CoA dehydrogenase activity
IS499_RS21990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS499_RS22000	COG0583	DNA-binding transcription factor activity
IS499_RS22010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS499_RS22020	COG2226	methyltransferase
IS499_RS22030	COG0741	lytic transglycosylase activity
IS499_RS22030	COG1388	LysM domain
IS499_RS22035	COG2226	methyltransferase
IS499_RS22045	COG2814	Major facilitator Superfamily
IS499_RS22050	COG0583	DNA-binding transcription factor activity
IS499_RS22055	COG0656	L-ascorbic acid biosynthetic process
IS499_RS22090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS499_RS22100	COG2011	ABC-type metal ion transport system permease component
IS499_RS22105	COG1464	Belongs to the NlpA lipoprotein family
IS499_RS22115	COG1720	tRNA m6t6A37 methyltransferase activity
IS499_RS22125	COG0791	NLP P60 protein
IS499_RS22130	COG3015	lipoprotein NlpE involved in copper resistance
IS499_RS22135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IS499_RS22150	COG4568	rho-dependent transcription termination
IS499_RS22160	COG0346	lactoylglutathione lyase activity
IS499_RS22165	COG1982	Orn Lys Arg decarboxylase major
IS499_RS22205	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IS499_RS22215	COG0750	zinc metalloprotease
IS499_RS22220	COG0575	Belongs to the CDS family
IS499_RS22230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IS499_RS22255	COG0024	Methionine aminopeptidase
IS499_RS22260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IS499_RS22275	COG3835	regulator
IS499_RS22280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS499_RS22300	COG2860	membrane
IS499_RS22320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS22325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS499_RS22330	COG1120	ATPase activity
IS499_RS22340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS499_RS22435	COG1643	Atp-dependent helicase
IS499_RS22440	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IS499_RS22460	COG0617	tRNA 3'-terminal CCA addition
IS499_RS22465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS499_RS22485	COG0726	polysaccharide deacetylase
IS499_RS22490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS22495	COG0842	Transport permease protein
IS499_RS22500	COG1131	(ABC) transporter
IS499_RS22505	COG0288	reversible hydration of carbon dioxide
IS499_RS22520	COG4993	Dehydrogenase
IS499_RS22525	COG2132	Multicopper oxidase
IS499_RS22575	COG3064	Membrane
IS499_RS22590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS499_RS22595	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS499_RS22600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IS499_RS22605	COG2186	Transcriptional regulator
IS499_RS22610	COG1113	amino acid transport
IS499_RS22615	COG2211	Major facilitator Superfamily
IS499_RS22620	COG3940	Belongs to the glycosyl hydrolase 43 family
IS499_RS22625	COG3725	Membrane protein required for beta-lactamase induction
IS499_RS22630	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS499_RS22640	COG4969	Belongs to the N-Me-Phe pilin family
IS499_RS22645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS499_RS22650	COG1459	type II secretion system
IS499_RS22675	COG0494	nUDIX hydrolase
IS499_RS22695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IS499_RS22700	COG0849	cell division
IS499_RS22725	COG0772	Belongs to the SEDS family
IS499_RS22740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IS499_RS22745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IS499_RS22750	COG0768	penicillin binding
IS499_RS22770	COG1609	Transcriptional regulator
IS499_RS22780	COG0028	Belongs to the TPP enzyme family
IS499_RS22825	COG0738	Major facilitator superfamily
IS499_RS22835	COG0583	DNA-binding transcription factor activity
IS499_RS22840	COG2271	Major facilitator Superfamily
IS499_RS22845	COG2814	Major facilitator Superfamily
IS499_RS22865	COG1178	ABC-type Fe3 transport system permease component
IS499_RS22875	COG0586	Pfam SNARE associated Golgi protein
IS499_RS22895	COG0235	Class ii aldolase
IS499_RS22900	COG0417	DNA replication proofreading
IS499_RS22910	COG0564	pseudouridine synthase activity
IS499_RS22920	COG3493	citrate carrier protein
IS499_RS22935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS499_RS22940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IS499_RS22950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS499_RS22995	COG0505	Belongs to the CarA family
IS499_RS23060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IS499_RS23085	COG1047	Peptidyl-prolyl cis-trans
IS499_RS23100	COG0196	riboflavin kinase activity
IS499_RS23110	COG0583	DNA-binding transcription factor activity
IS499_RS23135	COG4735	regulation of single-species biofilm formation
IS499_RS23140	COG1584	GPR1 FUN34 yaaH family protein
IS499_RS23145	COG0477	Major facilitator Superfamily
IS499_RS23150	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS499_RS23155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS499_RS23160	COG1115	amino acid carrier protein
IS499_RS23175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IS499_RS23185	COG0460	homoserine dehydrogenase
IS499_RS23185	COG0527	aspartate kinase activity
IS499_RS23195	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IS499_RS23205	COG0745	RESPONSE REGULATOR receiver
IS499_RS23210	COG4452	Inner membrane protein CreD
IS499_RS23215	COG2205	protein histidine kinase activity
IS499_RS23220	COG0745	RESPONSE REGULATOR receiver
IS499_RS23225	COG3045	CreA protein
IS499_RS23230	COG2207	Transcriptional regulator
IS499_RS23230	COG3708	Transcriptional regulator
IS499_RS23250	COG0741	lytic transglycosylase activity
IS499_RS23255	COG0488	(ABC) transporter
IS499_RS23265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IS499_RS23270	COG0560	Phosphoserine phosphatase
IS499_RS23275	COG3726	membrane protein affecting hemolysin expression
IS499_RS23305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS499_RS23310	COG0084	hydrolase, TatD family'
IS499_RS23315	COG4667	esterase of the alpha-beta hydrolase superfamily
IS499_RS23325	COG2823	Periplasmic or secreted lipoprotein
IS499_RS23335	COG1011	Hydrolase
IS499_RS23340	COG0456	acetyltransferase
IS499_RS23345	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IS499_RS23380	COG3706	GGDEF domain
IS499_RS23385	COG4114	ferric iron reductase
IS499_RS23390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS23390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS23395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS499_RS23400	COG2197	response regulator
IS499_RS23405	COG2197	response regulator
IS499_RS23420	COG2966	Psort location CytoplasmicMembrane, score
IS499_RS23435	COG1484	DNA-dependent DNA replication
IS499_RS23450	COG5464	transposase or invertase
IS499_RS23460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS499_RS23465	COG3716	PTS system mannose fructose sorbose family IID component
IS499_RS23470	COG3715	PTS system
IS499_RS23485	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS499_RS23485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS499_RS23495	COG1063	alcohol dehydrogenase
IS499_RS23500	COG1802	Transcriptional regulator
IS499_RS23505	COG2271	Major facilitator Superfamily
IS499_RS23510	COG1214	PFAM Peptidase M22, glycoprotease
IS499_RS23510	COG0456	acetyltransferase
IS499_RS23520	COG1737	Transcriptional regulator
IS499_RS23525	COG0800	Aldolase
IS499_RS23530	COG3734	2-keto-3-deoxy-galactonokinase
IS499_RS23545	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IS499_RS23575	COG1846	Transcriptional regulator
IS499_RS23585	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS499_RS23595	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS23600	COG3384	dioxygenase
IS499_RS23610	COG3971	2-oxopent-4-enoate hydratase activity
IS499_RS23630	COG2368	4-hydroxyphenylacetate
IS499_RS23635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS499_RS23650	COG1966	Carbon starvation protein
IS499_RS23655	COG2879	small protein
IS499_RS23660	COG0523	cobalamin synthesis protein
IS499_RS23670	COG1012	belongs to the aldehyde dehydrogenase family
IS499_RS23675	COG5464	transposase or invertase
IS499_RS23680	COG1917	Cupin 2, conserved barrel domain protein
IS499_RS23680	COG2207	Transcriptional regulator
IS499_RS23690	COG2733	membrane
IS499_RS23705	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IS499_RS23710	COG1924	4 iron, 4 sulfur cluster binding
IS499_RS23725	COG1566	PFAM secretion protein HlyD family protein
IS499_RS23735	COG5457	Domain of unknown function (DUF1127)
IS499_RS23740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS499_RS23750	COG0583	DNA-binding transcription factor activity
IS499_RS23755	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS499_RS23765	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS23770	COG1129	ABC transporter
IS499_RS23775	COG1879	ABC-type sugar transport system periplasmic component
IS499_RS23785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS23790	COG0842	Transport permease protein
IS499_RS23790	COG1129	ABC transporter
IS499_RS23795	COG0842	Transport permease protein
IS499_RS23825	COG2850	peptidyl-arginine hydroxylation
IS499_RS23840	COG5002	protein histidine kinase activity
IS499_RS23845	COG0745	RESPONSE REGULATOR receiver
IS499_RS23850	COG1538	Outer membrane efflux protein
IS499_RS23855	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS23860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS23865	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS499_RS23875	COG3040	lipid binding
IS499_RS23880	COG0789	Transcriptional regulator
IS499_RS23890	COG0300	oxidoreductase activity
IS499_RS23905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS499_RS23925	COG3272	Protein of unknown function (DUF1722)
IS499_RS23930	COG4580	involved in the transport of maltose and maltodextrins
IS499_RS23940	COG2211	Major facilitator Superfamily
IS499_RS23945	COG3507	Belongs to the glycosyl hydrolase 43 family
IS499_RS24050	COG3039	Transposase
IS499_RS24060	COG0582	viral genome integration into host DNA
IS499_RS24070	COG0288	reversible hydration of carbon dioxide
IS499_RS24075	COG0659	secondary active sulfate transmembrane transporter activity
IS499_RS24080	COG1064	alcohol dehydrogenase
IS499_RS24085	COG1175	transmembrane transport
IS499_RS24090	COG0395	ABC-type sugar transport system, permease component
IS499_RS24095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS499_RS24100	COG3842	ATPase activity
IS499_RS24105	COG1653	transport
IS499_RS24115	COG1082	Xylose isomerase domain protein TIM barrel
IS499_RS24125	COG3962	Belongs to the TPP enzyme family
IS499_RS24130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS24135	COG0837	glucose binding
IS499_RS24135	COG1737	Transcriptional regulator
IS499_RS24140	COG3718	enzyme involved in inositol metabolism
IS499_RS24155	COG0433	COG0433 Predicted ATPase
IS499_RS24160	COG0795	lipopolysaccharide-transporting ATPase activity
IS499_RS24165	COG0795	lipopolysaccharide-transporting ATPase activity
IS499_RS24175	COG2927	DNA polymerase III (CHI subunit)
IS499_RS24180	COG0525	valine-tRNA ligase activity
IS499_RS24205	COG2188	Transcriptional regulator
IS499_RS24210	COG1288	antiporter activity
IS499_RS24215	COG1228	amidohydrolase
IS499_RS24220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS24225	COG2222	sugar isomerase
IS499_RS24230	COG2731	YhcH YjgK YiaL family protein
IS499_RS24265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS499_RS24265	COG1263	PTS System
IS499_RS24270	COG0366	Alpha amylase catalytic
IS499_RS24275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS499_RS24280	COG1486	melibiose metabolic process
IS499_RS24305	COG0602	queuosine metabolic process
IS499_RS24310	COG2026	Addiction module toxin, RelE StbE family
IS499_RS24315	COG3077	Addiction module antitoxin, RelB DinJ family
IS499_RS24320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS499_RS24320	COG3711	transcriptional antiterminator
IS499_RS24325	COG2706	6-phosphogluconolactonase activity
IS499_RS24340	COG3964	amidohydrolase
IS499_RS24380	COG0312	modulator of DNA gyrase
IS499_RS24405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS499_RS24415	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS24420	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS24425	COG1129	ABC transporter
IS499_RS24430	COG1879	ABC-type sugar transport system periplasmic component
IS499_RS24450	COG2105	PFAM AIG2 family protein
IS499_RS24455	COG2911	Protein conserved in bacteria
IS499_RS24460	COG0729	surface antigen
IS499_RS24470	COG1253	flavin adenine dinucleotide binding
IS499_RS24485	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IS499_RS24500	COG1733	regulation of RNA biosynthetic process
IS499_RS24505	COG0702	epimerase
IS499_RS24515	COG0697	spore germination
IS499_RS24525	COG1113	amino acid transport
IS499_RS24530	COG0545	Peptidyl-prolyl cis-trans isomerase
IS499_RS24535	COG3061	Opacity-associated protein A
IS499_RS24545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IS499_RS24550	COG2965	DNA replication, synthesis of RNA primer
IS499_RS24610	COG1073	alpha beta
IS499_RS24615	COG3650	response to hydrogen peroxide
IS499_RS24625	COG1960	acyl-CoA dehydrogenase activity
IS499_RS24630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS499_RS24635	COG0557	exoribonuclease II activity
IS499_RS24650	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IS499_RS24660	COG0330	HflC and HflK could
IS499_RS24665	COG0330	HflC and HflK could
IS499_RS24670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS499_RS24690	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS499_RS24695	COG0802	atpase or kinase
IS499_RS24700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IS499_RS24700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IS499_RS24705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS499_RS24725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS499_RS24745	COG3264	Mechanosensitive ion channel
IS499_RS24745	COG1511	domain protein
IS499_RS24760	COG1053	succinate dehydrogenase
IS499_RS24765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS499_RS24785	COG2076	Multidrug Resistance protein
IS499_RS24790	COG5510	response to toxic substance
IS499_RS24805	COG1509	lysine 2,3-aminomutase activity
IS499_RS24875	COG0531	amino acid
IS499_RS24880	COG3030	protein affecting phage T7 exclusion by the F plasmid
IS499_RS24885	COG1027	Aspartate ammonia-lyase
IS499_RS24890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS499_RS24905	COG1309	transcriptional regulator
IS499_RS24935	COG0457	Tetratricopeptide repeat
IS499_RS24940	COG1649	PFAM Uncharacterised BCR, COG1649
IS499_RS24940	COG0726	polysaccharide deacetylase
IS499_RS24945	COG1215	transferase activity, transferring glycosyl groups
IS499_RS24960	COG0861	Integral membrane protein TerC family
IS499_RS25005	COG1486	melibiose metabolic process
IS499_RS25010	COG2169	Transcriptional regulator
IS499_RS25020	COG2824	Alkylphosphonate utilization operon protein PhnA
IS499_RS25025	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IS499_RS25030	COG2188	Transcriptional regulator
IS499_RS25035	COG3624	Phosphonate C-P lyase system protein PhnG
IS499_RS25040	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IS499_RS25045	COG3626	phosphonate metabolism
IS499_RS25050	COG3627	carbon phosphorus lyase activity
IS499_RS25055	COG4107	phosphonate C-P lyase system protein PhnK
IS499_RS25060	COG4778	phosphonate C-P lyase system protein PhnL
IS499_RS25065	COG3454	Phosphonate metabolism
IS499_RS25075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IS499_RS25085	COG4191	Histidine kinase
IS499_RS25085	COG0784	Response regulator, receiver
IS499_RS25090	COG1129	ABC transporter
IS499_RS25095	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS25130	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IS499_RS25135	COG1301	dicarboxylic acid transport
IS499_RS25145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS499_RS25150	COG3162	membrane
IS499_RS25180	COG3539	Fimbrial protein
IS499_RS25185	COG1346	cytolysis
IS499_RS25190	COG1380	Effector of murein hydrolase LrgA
IS499_RS25195	COG0583	DNA-binding transcription factor activity
IS499_RS25200	COG0025	NhaP-type Na H and K H
IS499_RS25205	COG2252	PERMEase
IS499_RS25210	COG0625	glutathione transferase activity
IS499_RS25215	COG0789	Transcriptional regulator
IS499_RS25225	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS499_RS25255	COG1234	tRNA 3'-trailer cleavage
IS499_RS25260	COG1609	Transcriptional regulator
IS499_RS25265	COG0483	inositol monophosphate 1-phosphatase activity
IS499_RS25275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS499_RS25295	COG4771	TonB-dependent receptor
IS499_RS25300	COG0741	lytic transglycosylase activity
IS499_RS25315	COG2315	Protein conserved in bacteria
IS499_RS25320	COG0432	Pfam Uncharacterised protein family UPF0047
IS499_RS25335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IS499_RS25340	COG0305	Participates in initiation and elongation during chromosome replication
IS499_RS25355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS499_RS25365	COG0735	belongs to the Fur family
IS499_RS25370	COG3237	CsbD-like
IS499_RS25380	COG0534	Mate efflux family protein
IS499_RS25390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IS499_RS25460	COG0251	oxidation-reduction process
IS499_RS25470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IS499_RS25480	COG0527	aspartate kinase activity
IS499_RS25535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS499_RS25565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IS499_RS25575	COG0456	acetyltransferase
IS499_RS25605	COG0151	Belongs to the GarS family
IS499_RS25615	COG4191	Histidine kinase
IS499_RS25620	COG3678	ATP-independent chaperone mediated protein folding
IS499_RS25655	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IS499_RS25670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS499_RS25675	COG2104	thiamine diphosphate biosynthetic process
IS499_RS25690	COG3706	GGDEF domain
IS499_RS25700	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS499_RS25705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS499_RS25740	COG0250	Participates in transcription elongation, termination and antitermination
IS499_RS25785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IS499_RS25815	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IS499_RS25825	COG1739	Uncharacterized protein family UPF0029
IS499_RS25865	COG0805	protein transport
IS499_RS25885	COG3165	ubiquinone biosynthetic process from chorismate
IS499_RS25915	COG0583	DNA-binding transcription factor activity
IS499_RS25920	COG0697	spore germination
IS499_RS25925	COG0561	phosphatase activity
IS499_RS25930	COG2267	carboxylic ester hydrolase activity
IS499_RS25935	COG1280	lysine exporter protein (LysE YggA)
IS499_RS25945	COG1280	lysine exporter protein (LysE YggA)
IS499_RS25975	COG0210	DNA helicase
IS499_RS25980	COG1011	Hydrolase
IS499_RS26010	COG3072	Adenylate cyclase
IS499_RS26025	COG2959	enzyme of heme biosynthesis
IS499_RS26030	COG3071	HemY protein
IS499_RS26075	COG2244	polysaccharide biosynthetic process
IS499_RS26080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IS499_RS26085	COG0456	acetyltransferase
IS499_RS26090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IS499_RS26095	COG1088	dTDP-glucose 4,6-dehydratase activity
IS499_RS26100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IS499_RS26105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IS499_RS26115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS499_RS26120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IS499_RS26125	COG3118	belongs to the thioredoxin family
IS499_RS26150	COG1811	Na channel or pump
IS499_RS26160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS499_RS26165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS499_RS26175	COG0583	DNA-binding transcription factor activity
IS499_RS26180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS499_RS26195	COG3978	acetolactate synthase activity
IS499_RS26215	COG3085	chromosome segregation
IS499_RS26290	COG0583	DNA-binding transcription factor activity
IS499_RS26305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IS499_RS26320	COG3443	Belongs to the bacterial solute-binding protein 9 family
IS499_RS26325	COG2207	Transcriptional regulator
IS499_RS26335	COG0371	Dehydrogenase
IS499_RS26340	COG0697	spore germination
IS499_RS26350	COG0583	DNA-binding transcription factor activity
IS499_RS26360	COG0737	Belongs to the 5'-nucleotidase family
IS499_RS26370	COG0527	aspartate kinase activity
IS499_RS26370	COG0460	homoserine dehydrogenase
IS499_RS26375	COG0626	cystathionine gamma-synthase activity
IS499_RS26390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IS499_RS26395	COG1609	Transcriptional regulator
IS499_RS26400	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS499_RS26415	COG1575	Belongs to the MenA family. Type 1 subfamily
IS499_RS26435	COG3678	ATP-independent chaperone mediated protein folding
IS499_RS26440	COG0745	RESPONSE REGULATOR receiver
IS499_RS26445	COG2205	protein histidine kinase activity
IS499_RS26450	COG2258	MOSC domain
IS499_RS26455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IS499_RS26495	COG1129	ABC transporter
IS499_RS26500	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS26505	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS26510	COG1454	alcohol dehydrogenase
IS499_RS26520	COG2211	Major facilitator Superfamily
IS499_RS26580	COG0205	6-phosphofructokinase activity
IS499_RS26600	COG0437	4 iron, 4 sulfur cluster binding
IS499_RS26605	COG2864	formate dehydrogenase
IS499_RS26620	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IS499_RS26625	COG0657	acetylesterase activity
IS499_RS26630	COG0456	acetyltransferase
IS499_RS26645	COG1011	Hydrolase
IS499_RS26660	COG3852	Histidine kinase
IS499_RS26675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS499_RS26695	COG0204	Acyl-transferase
IS499_RS26705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IS499_RS26710	COG3084	Protein conserved in bacteria
IS499_RS26720	COG1763	Mo-molybdopterin cofactor biosynthetic process
IS499_RS26745	COG2186	Transcriptional regulator
IS499_RS26750	COG0477	Major facilitator Superfamily
IS499_RS26755	COG1609	Transcriptional regulator
IS499_RS26760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS499_RS26770	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS499_RS26775	COG1129	ABC transporter
IS499_RS26805	COG1522	sequence-specific DNA binding
IS499_RS26810	COG0716	FMN binding
IS499_RS26825	COG3312	ion transport
IS499_RS26875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS499_RS26880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS499_RS26885	COG0573	inorganic phosphate transmembrane transporter activity
IS499_RS26890	COG0581	inorganic phosphate transmembrane transporter activity
IS499_RS26895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS499_RS26900	COG0704	Plays a role in the regulation of phosphate uptake
IS499_RS26910	COG2382	esterase
IS499_RS26915	COG0363	glucosamine-6-phosphate deaminase activity
IS499_RS26920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS499_RS26925	COG2252	PERMEase
IS499_RS26930	COG0431	NADPH-dependent FMN reductase
IS499_RS26935	COG2091	lysine biosynthetic process via aminoadipic acid
IS499_RS26965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IS499_RS26995	COG1358	cellular component organization or biogenesis
IS499_RS27015	COG4245	von Willebrand factor, type A
IS499_RS27025	COG4245	von Willebrand factor, type A
IS499_RS27030	COG4245	von Willebrand factor, type A
IS499_RS27050	COG4372	Transposase
IS499_RS27055	COG3436	PFAM IS66 Orf2 family protein
IS499_RS27100	COG2144	transferase activity, transferring acyl groups
IS499_RS27125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS499_RS27215	COG4372	Transposase
IS499_RS27220	COG3436	PFAM IS66 Orf2 family protein
IS499_RS27385	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS499_RS27415	COG0739	heme binding
IS499_RS27425	COG2132	Multicopper oxidase
IS499_RS27430	COG3667	copper resistance
IS499_RS27435	COG2372	response to copper ion
IS499_RS27440	COG1276	copper resistance
IS499_RS27445	COG0745	RESPONSE REGULATOR receiver
IS499_RS27450	COG2205	protein histidine kinase activity
IS499_RS27465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IS499_RS27480	COG0789	Transcriptional regulator
IS499_RS27535	COG5499	transcription regulator containing HTH domain
IS499_RS27540	COG4680	protein conserved in bacteria
IS499_RS27605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IS499_RS27645	COG0523	cobalamin synthesis protein
IS499_RS27670	COG0523	cobalamin synthesis protein
IS499_RS27675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IS499_RS27680	COG0735	belongs to the Fur family
IS499_RS27725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS499_RS27750	COG0656	L-ascorbic acid biosynthetic process
IS499_RS27760	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS499_RS27780	COG5654	RES domain protein
IS499_RS27785	COG5642	Protein of unknown function (DUF2384)
IS499_RS27830	COG0500	methyltransferase
IS499_RS27865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IS499_RS27875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS499_RS27895	COG0523	cobalamin synthesis protein
IS499_RS28065	COG1522	sequence-specific DNA binding
IS499_RS28080	COG1028	Short-chain dehydrogenase reductase Sdr
IS499_RS28080	COG0604	alcohol dehydrogenase
IS499_RS28080	COG3321	synthase
IS499_RS28330	COG3436	PFAM IS66 Orf2 family protein
IS499_RS28335	COG4372	Transposase
IS499_RS28510	COG3344	reverse transcriptase
IS499_RS28645	COG2084	Dehydrogenase
IS499_RS28650	COG1349	DNA-binding transcription factor activity
IS499_RS28810	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IS499_RS28960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IS499_RS29040	COG3344	reverse transcriptase
IS499_RS29140	COG4372	Transposase
IS499_RS29145	COG3436	PFAM IS66 Orf2 family protein
IS499_RS29290	COG3344	reverse transcriptase
IS499_RS29310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS499_RS29420	COG0741	lytic transglycosylase activity
IS499_RS29445	COG0784	Response regulator, receiver
IS499_RS29445	COG2198	Histidine kinase
IS499_RS29445	COG5002	protein histidine kinase activity
IS499_RS29525	COG2003	Belongs to the UPF0758 family
IS499_RS29635	COG0768	penicillin binding
IS499_RS29650	COG0697	spore germination
IS499_RS29755	COG3064	Membrane
IS499_RS29765	COG3344	reverse transcriptase