locus-tag	class	description
IS503_RS00020	COG0187	DNA topoisomerase II activity
IS503_RS00025	COG0561	phosphatase activity
IS503_RS00040	COG2186	Transcriptional regulator
IS503_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
IS503_RS00050	COG0800	Aldolase
IS503_RS00060	COG2271	Major facilitator Superfamily
IS503_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
IS503_RS00070	COG5645	(Lipo)protein
IS503_RS00085	COG3645	SOS response
IS503_RS00095	COG2188	Transcriptional regulator
IS503_RS00110	COG2149	membrane
IS503_RS00130	COG2610	gluconate transmembrane transporter activity
IS503_RS00140	COG0583	DNA-binding transcription factor activity
IS503_RS00145	COG2814	Major facilitator Superfamily
IS503_RS00175	COG0028	Belongs to the TPP enzyme family
IS503_RS00180	COG0440	acetolactate synthase activity
IS503_RS00185	COG2197	response regulator
IS503_RS00195	COG2271	Major facilitator Superfamily
IS503_RS00235	COG2188	Transcriptional regulator
IS503_RS00260	COG4580	involved in the transport of maltose and maltodextrins
IS503_RS00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS503_RS00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS00280	COG1609	Transcriptional regulator
IS503_RS00290	COG3384	dioxygenase
IS503_RS00295	COG0583	DNA-binding transcription factor activity
IS503_RS00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IS503_RS00305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS503_RS00310	COG2828	Protein conserved in bacteria
IS503_RS00325	COG0697	spore germination
IS503_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS00330	COG1263	PTS System
IS503_RS00340	COG2814	Major facilitator Superfamily
IS503_RS00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS503_RS00385	COG0583	DNA-binding transcription factor activity
IS503_RS00410	COG1464	Belongs to the NlpA lipoprotein family
IS503_RS00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IS503_RS00435	COG1064	alcohol dehydrogenase
IS503_RS00470	COG0582	viral genome integration into host DNA
IS503_RS00480	COG2211	Major facilitator Superfamily
IS503_RS00485	COG1501	Belongs to the glycosyl hydrolase 31 family
IS503_RS00495	COG1486	melibiose metabolic process
IS503_RS00500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS00500	COG1263	PTS System
IS503_RS00505	COG2982	Protein involved in outer membrane biogenesis
IS503_RS00510	COG2233	PERMEase
IS503_RS00515	COG0786	glutamate:sodium symporter activity
IS503_RS00535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IS503_RS00560	COG3152	Membrane
IS503_RS00570	COG1494	fructose-1,6-bisphosphatase
IS503_RS00575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IS503_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS503_RS00585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS503_RS00605	COG2860	membrane
IS503_RS00615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS503_RS00615	COG2169	Transcriptional regulator
IS503_RS00620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IS503_RS00625	COG1561	YicC-like family, N-terminal region
IS503_RS00645	COG1131	(ABC) transporter
IS503_RS00650	COG0842	Transport permease protein
IS503_RS00680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IS503_RS00715	COG1519	Transferase
IS503_RS00720	COG1216	Glycosyl transferase, family 2
IS503_RS00725	COG0438	transferase activity, transferring glycosyl groups
IS503_RS00735	COG0859	PFAM glycosyl transferase family 9
IS503_RS00760	COG0859	PFAM glycosyl transferase family 9
IS503_RS00775	COG0156	8-amino-7-oxononanoate synthase activity
IS503_RS00785	COG0463	Glycosyl transferase, family 2
IS503_RS00790	COG2861	carbohydrate metabolic process
IS503_RS00795	COG4942	peptidase
IS503_RS00805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS503_RS00810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS503_RS00830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IS503_RS00840	COG2186	Transcriptional regulator
IS503_RS00860	COG3722	fumarate hydratase activity
IS503_RS00880	COG0625	glutathione transferase activity
IS503_RS00890	COG3276	selenocysteine insertion sequence binding
IS503_RS00895	COG1414	Transcriptional regulator
IS503_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS503_RS00905	COG3977	Valine--pyruvate aminotransferase
IS503_RS00910	COG0366	Alpha amylase catalytic
IS503_RS00915	COG2992	FlgJ-related protein
IS503_RS00920	COG2207	Transcriptional regulator
IS503_RS00920	COG1609	Transcriptional regulator
IS503_RS00925	COG4214	carbohydrate transport
IS503_RS00935	COG4213	ABC transporter substrate-binding protein
IS503_RS00950	COG4682	membrane
IS503_RS00955	COG4682	membrane
IS503_RS00960	COG3274	enterobacterial common antigen metabolic process
IS503_RS00990	COG1278	Cold shock
IS503_RS00995	COG2944	sequence-specific DNA binding
IS503_RS01000	COG2814	Major facilitator Superfamily
IS503_RS01020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS503_RS01030	COG1609	Transcriptional regulator
IS503_RS01035	COG2885	chlorophyll binding
IS503_RS01040	COG0243	molybdopterin cofactor binding
IS503_RS01045	COG0456	acetyltransferase
IS503_RS01050	COG2818	Glycosylase
IS503_RS01055	COG5571	outer membrane autotransporter
IS503_RS01060	COG2223	nitrite transmembrane transporter activity
IS503_RS01085	COG0747	negative chemotaxis
IS503_RS01090	COG0601	transmembrane transport
IS503_RS01095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS01100	COG0444	Belongs to the ABC transporter superfamily
IS503_RS01105	COG4608	Belongs to the ABC transporter superfamily
IS503_RS01120	COG2894	cell division
IS503_RS01130	COG1215	transferase activity, transferring glycosyl groups
IS503_RS01135	COG0457	Tetratricopeptide repeat
IS503_RS01150	COG2194	sulfuric ester hydrolase activity
IS503_RS01180	COG1215	transferase activity, transferring glycosyl groups
IS503_RS01185	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IS503_RS01190	COG0457	Tetratricopeptide repeat
IS503_RS01190	COG3118	belongs to the thioredoxin family
IS503_RS01195	COG2199	diguanylate cyclase activity
IS503_RS01195	COG2200	EAL domain
IS503_RS01205	COG0612	Peptidase, M16
IS503_RS01215	COG2982	Protein involved in outer membrane biogenesis
IS503_RS01220	COG0477	Major facilitator Superfamily
IS503_RS01225	COG1295	ribonuclease BN
IS503_RS01230	COG0583	DNA-binding transcription factor activity
IS503_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS01240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS503_RS01250	COG1454	alcohol dehydrogenase
IS503_RS01260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS503_RS01265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IS503_RS01270	COG0671	phosphoesterase, PA-phosphatase related
IS503_RS01290	COG0589	response to stress
IS503_RS01300	COG0306	phosphate transporter
IS503_RS01305	COG2081	HI0933 family
IS503_RS01310	COG2239	Acts as a magnesium transporter
IS503_RS01325	COG1124	(ABC) transporter
IS503_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS01340	COG0601	transmembrane transport
IS503_RS01345	COG0747	negative chemotaxis
IS503_RS01355	COG3479	Phenolic acid decarboxylase
IS503_RS01395	COG0628	permease
IS503_RS01400	COG0477	Major facilitator Superfamily
IS503_RS01410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS503_RS01425	COG3714	YhhN family
IS503_RS01435	COG3776	membrane
IS503_RS01440	COG0742	ribosomal rna small subunit methyltransferase
IS503_RS01445	COG0552	protein localization to endoplasmic reticulum
IS503_RS01450	COG2884	Cell division ATP-binding protein ftsE
IS503_RS01455	COG2177	Part of the ABC transporter FtsEX involved in
IS503_RS01470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS503_RS01480	COG0683	leucine binding
IS503_RS01490	COG0683	leucine binding
IS503_RS01495	COG0559	Belongs to the binding-protein-dependent transport system permease family
IS503_RS01545	COG0584	glycerophosphoryl diester phosphodiesterase
IS503_RS01555	COG0405	Gamma-glutamyltransferase
IS503_RS01560	COG1247	-acetyltransferase
IS503_RS01570	COG0673	inositol 2-dehydrogenase activity
IS503_RS01575	COG1741	Belongs to the pirin family
IS503_RS01580	COG1609	Transcriptional regulator
IS503_RS01585	COG3265	gluconokinase activity
IS503_RS01590	COG2610	gluconate transmembrane transporter activity
IS503_RS01600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS503_RS01625	COG0058	SHG alpha-glucan phosphorylase activity
IS503_RS01630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS503_RS01645	COG1349	DNA-binding transcription factor activity
IS503_RS01655	COG0058	SHG alpha-glucan phosphorylase activity
IS503_RS01660	COG1640	4-alpha-glucanotransferase
IS503_RS01665	COG2610	gluconate transmembrane transporter activity
IS503_RS01675	COG1040	competence protein
IS503_RS01700	COG1918	ferrous iron import across plasma membrane
IS503_RS01705	COG2183	response to ionizing radiation
IS503_RS01710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS503_RS01735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IS503_RS01740	COG1011	Hydrolase
IS503_RS01750	COG0494	nUDIX hydrolase
IS503_RS01755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IS503_RS01780	COG4796	Type ii and iii secretion system protein
IS503_RS01795	COG3266	domain, Protein
IS503_RS01800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IS503_RS01805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS503_RS01830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS503_RS01835	COG0402	S-adenosylhomocysteine deaminase activity
IS503_RS01840	COG0738	Major facilitator superfamily
IS503_RS01865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS503_RS01870	COG1289	transmembrane transporter activity
IS503_RS01880	COG1765	OsmC-like protein
IS503_RS01885	COG3954	Phosphoribulokinase
IS503_RS01895	COG0429	hydrolase of the alpha beta-hydrolase fold
IS503_RS01900	COG0488	(ABC) transporter
IS503_RS01915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IS503_RS01920	COG1047	Peptidyl-prolyl cis-trans
IS503_RS01930	COG0545	Peptidyl-prolyl cis-trans isomerase
IS503_RS01935	COG2964	Protein conserved in bacteria
IS503_RS01990	COG0051	transcription antitermination factor activity, RNA binding
IS503_RS02015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IS503_RS02030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IS503_RS02095	COG0201	protein transport
IS503_RS02120	COG0202	RNA polymerase activity
IS503_RS02135	COG0789	Transcriptional regulator
IS503_RS02140	COG3036	rescue of stalled ribosome
IS503_RS02170	COG0758	DNA mediated transformation
IS503_RS02180	COG0551	DNA topoisomerase type I activity
IS503_RS02200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS503_RS02235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS503_RS02240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS02245	COG1309	transcriptional regulator
IS503_RS02265	COG4145	pantothenate transmembrane transporter activity
IS503_RS02270	COG3924	membrane
IS503_RS02275	COG0439	Biotin carboxylase
IS503_RS02280	COG0511	ligase activity, forming carbon-carbon bonds
IS503_RS02305	COG2200	EAL domain
IS503_RS02305	COG2199	diguanylate cyclase activity
IS503_RS02310	COG1077	Cell shape determining protein MreB Mrl
IS503_RS02315	COG1792	Involved in formation and maintenance of cell shape
IS503_RS02320	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IS503_RS02330	COG1530	ribonuclease E activity
IS503_RS02335	COG3164	Protein of unknown function
IS503_RS02340	COG0312	modulator of DNA gyrase
IS503_RS02345	COG0583	DNA-binding transcription factor activity
IS503_RS02360	COG1289	transmembrane transporter activity
IS503_RS02365	COG2732	(Barnase) inhibitor
IS503_RS02400	COG0471	metal ion transport
IS503_RS02405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS503_RS02410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS503_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS503_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS503_RS02445	COG3105	Protein conserved in bacteria
IS503_RS02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS503_RS02470	COG0625	glutathione transferase activity
IS503_RS02475	COG2969	positive regulation of protein catabolic process
IS503_RS02485	COG0493	'glutamate synthase
IS503_RS02490	COG0069	glutamate synthase activity
IS503_RS02490	COG0070	glutamate synthase
IS503_RS02490	COG0067	glutamate synthase
IS503_RS02495	COG1242	4 iron, 4 sulfur cluster binding
IS503_RS02500	COG2271	Major facilitator Superfamily
IS503_RS02505	COG1063	alcohol dehydrogenase
IS503_RS02510	COG1312	Catalyzes the dehydration of D-mannonate
IS503_RS02515	COG5002	protein histidine kinase activity
IS503_RS02515	COG2198	Histidine kinase
IS503_RS02515	COG0784	Response regulator, receiver
IS503_RS02520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IS503_RS02525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS503_RS02530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS02540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS02545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS503_RS02550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IS503_RS02555	COG1137	ATPase activity
IS503_RS02560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IS503_RS02565	COG3117	lipopolysaccharide transmembrane transporter activity
IS503_RS02570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IS503_RS02580	COG0530	calcium, potassium:sodium antiporter activity
IS503_RS02585	COG1127	ABC transporter
IS503_RS02590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS503_RS02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS503_RS02600	COG2854	intermembrane phospholipid transfer
IS503_RS02605	COG3113	response to antibiotic
IS503_RS02610	COG5007	Belongs to the BolA IbaG family
IS503_RS02620	COG3423	Transcriptional regulator
IS503_RS02625	COG0142	geranyltranstransferase activity
IS503_RS02640	COG0697	spore germination
IS503_RS02650	COG2027	D-alanyl-D-alanine carboxypeptidase
IS503_RS02660	COG1534	Rna-binding protein
IS503_RS02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IS503_RS02675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IS503_RS02685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IS503_RS02725	COG0195	Participates in both transcription termination and antitermination
IS503_RS02770	COG0814	amino acid
IS503_RS02775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS503_RS02780	COG0826	peptidase U32
IS503_RS02785	COG0826	peptidase U32
IS503_RS02790	COG3154	lipid carrier protein
IS503_RS02795	COG3153	acetyltransferase
IS503_RS02810	COG0693	protein deglycase activity
IS503_RS02815	COG0702	epimerase
IS503_RS02820	COG0701	Predicted permease
IS503_RS02825	COG2823	Periplasmic or secreted lipoprotein
IS503_RS02845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IS503_RS02860	COG1063	alcohol dehydrogenase
IS503_RS02865	COG3775	system Galactitol-specific IIC component
IS503_RS02870	COG3414	Phosphotransferase system galactitol-specific IIB component
IS503_RS02875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS02885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS02885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS02890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS02890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS02890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS02895	COG1105	Belongs to the carbohydrate kinase PfkB family
IS503_RS02905	COG1349	DNA-binding transcription factor activity
IS503_RS02910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS503_RS02915	COG2721	sulfolactate sulfo-lyase activity
IS503_RS02920	COG2271	Major facilitator Superfamily
IS503_RS02930	COG2084	Dehydrogenase
IS503_RS02935	COG1929	Belongs to the glycerate kinase type-1 family
IS503_RS02960	COG1741	Belongs to the pirin family
IS503_RS02965	COG0583	DNA-binding transcription factor activity
IS503_RS02970	COG3152	Membrane
IS503_RS02975	COG0435	Glutathione S-transferase
IS503_RS02980	COG2259	Doxx family
IS503_RS02990	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IS503_RS02995	COG4575	ribosome binding
IS503_RS03000	COG1422	Protein of unknown function (DUF1090)
IS503_RS03010	COG0586	Pfam SNARE associated Golgi protein
IS503_RS03015	COG2186	Transcriptional regulator
IS503_RS03020	COG2271	Major facilitator Superfamily
IS503_RS03030	COG2721	sulfolactate sulfo-lyase activity
IS503_RS03045	COG0861	Integral membrane protein TerC family
IS503_RS03050	COG0673	inositol 2-dehydrogenase activity
IS503_RS03055	COG1451	nucleotide metabolic process
IS503_RS03075	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS503_RS03075	COG1902	pentaerythritol trinitrate reductase activity
IS503_RS03125	COG1695	Transcriptional regulator
IS503_RS03130	COG2375	cellular response to nickel ion
IS503_RS03145	COG1461	Dihydroxyacetone kinase
IS503_RS03150	COG2376	Dihydroxyacetone kinase
IS503_RS03220	COG3247	response to pH
IS503_RS03230	COG0784	Response regulator, receiver
IS503_RS03230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS03230	COG2198	Histidine kinase
IS503_RS03230	COG2205	protein histidine kinase activity
IS503_RS03235	COG2197	response regulator
IS503_RS03260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS503_RS03265	COG0358	DNA primase activity
IS503_RS03270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IS503_RS03335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS503_RS03350	COG4991	sh3 domain protein
IS503_RS03355	COG3025	triphosphatase activity
IS503_RS03380	COG2960	long-chain fatty acid transporting porin activity
IS503_RS03395	COG3384	dioxygenase
IS503_RS03400	COG0754	glutathionylspermidine amidase activity
IS503_RS03415	COG0494	nUDIX hydrolase
IS503_RS03420	COG3151	Protein conserved in bacteria
IS503_RS03425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS503_RS03430	COG3150	esterase
IS503_RS03440	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IS503_RS03450	COG0642	Histidine kinase
IS503_RS03460	COG3111	PFAM Bacterial OB fold (BOF) protein
IS503_RS03465	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IS503_RS03470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IS503_RS03475	COG0204	Acyl-transferase
IS503_RS03480	COG2132	Multicopper oxidase
IS503_RS03485	COG1032	radical SAM domain protein
IS503_RS03495	COG0656	L-ascorbic acid biosynthetic process
IS503_RS03500	COG1979	alcohol dehydrogenase
IS503_RS03505	COG2207	Transcriptional regulator
IS503_RS03510	COG0586	Pfam SNARE associated Golgi protein
IS503_RS03515	COG0626	cystathionine gamma-synthase activity
IS503_RS03525	COG0848	biopolymer transport protein
IS503_RS03530	COG2211	Major facilitator Superfamily
IS503_RS03555	COG0625	glutathione transferase activity
IS503_RS03570	COG0754	glutathionylspermidine amidase activity
IS503_RS03575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS503_RS03600	COG0626	cystathionine gamma-synthase activity
IS503_RS03635	COG1811	Na channel or pump
IS503_RS03640	COG1982	Orn Lys Arg decarboxylase major
IS503_RS03645	COG2211	Major facilitator Superfamily
IS503_RS03660	COG1194	a g-specific adenine glycosylase
IS503_RS03670	COG3171	Protein conserved in bacteria
IS503_RS03680	COG4214	carbohydrate transport
IS503_RS03695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS503_RS03710	COG0762	integral membrane protein
IS503_RS03715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IS503_RS03720	COG2805	Type II/IV secretion system protein
IS503_RS03740	COG0189	ligase activity
IS503_RS03745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IS503_RS03750	COG2356	endonuclease I
IS503_RS03760	COG2814	Major facilitator Superfamily
IS503_RS03795	COG0501	Belongs to the peptidase M48B family
IS503_RS03800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS503_RS03815	COG0191	fructose-bisphosphate aldolase activity
IS503_RS03820	COG0668	transmembrane transport
IS503_RS03830	COG2968	Membrane
IS503_RS03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS503_RS03850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IS503_RS03870	COG0006	proline dipeptidase activity
IS503_RS03875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS503_RS03880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS503_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS03905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS503_RS03925	COG2723	6-phospho-beta-galactosidase activity
IS503_RS03930	COG1737	Transcriptional regulator
IS503_RS03940	COG1272	protein, Hemolysin III
IS503_RS03950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IS503_RS03960	COG0716	FMN binding
IS503_RS03965	COG4974	Belongs to the 'phage' integrase family
IS503_RS03975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IS503_RS03995	COG4942	peptidase
IS503_RS04005	COG2814	Major facilitator Superfamily
IS503_RS04020	COG0667	Aldo Keto reductase
IS503_RS04060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS503_RS04065	COG1393	Belongs to the ArsC family
IS503_RS04080	COG1538	Outer membrane efflux protein
IS503_RS04085	COG1289	transmembrane transporter activity
IS503_RS04100	COG3592	Divergent 4Fe-4S mono-cluster
IS503_RS04105	COG2388	GCN5-related N-acetyl-transferase
IS503_RS04115	COG3539	Fimbrial protein
IS503_RS04120	COG3539	Fimbrial protein
IS503_RS04125	COG3539	Fimbrial protein
IS503_RS04130	COG3188	usher protein
IS503_RS04135	COG3121	Chaperone
IS503_RS04140	COG3539	Fimbrial protein
IS503_RS04150	COG4974	Belongs to the 'phage' integrase family
IS503_RS04155	COG0582	viral genome integration into host DNA
IS503_RS04165	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS503_RS04170	COG1846	Transcriptional regulator
IS503_RS04175	COG0697	spore germination
IS503_RS04225	COG0667	Aldo Keto reductase
IS503_RS04230	COG0814	amino acid
IS503_RS04245	COG0183	Belongs to the thiolase family
IS503_RS04255	COG0823	Involved in the tonB-independent uptake of proteins
IS503_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS04265	COG2814	Major facilitator Superfamily
IS503_RS04300	COG3842	ATPase activity
IS503_RS04305	COG0395	ABC-type sugar transport system, permease component
IS503_RS04310	COG1175	transmembrane transport
IS503_RS04315	COG1917	Cupin 2, conserved barrel domain protein
IS503_RS04320	COG1794	racemase activity, acting on amino acids and derivatives
IS503_RS04325	COG0583	DNA-binding transcription factor activity
IS503_RS04335	COG1609	Transcriptional regulator
IS503_RS04340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS04345	COG2723	6-phospho-beta-galactosidase activity
IS503_RS04350	COG2186	Transcriptional regulator
IS503_RS04360	COG1609	Transcriptional regulator
IS503_RS04380	COG0667	Aldo Keto reductase
IS503_RS04390	COG0861	Integral membrane protein TerC family
IS503_RS04425	COG2165	general secretion pathway protein
IS503_RS04430	COG4795	General secretion pathway protein
IS503_RS04440	COG4967	type IV pilus modification protein PilV
IS503_RS04445	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IS503_RS04450	COG1025	Belongs to the peptidase M16 family
IS503_RS04455	COG1074	ATP-dependent DNA helicase activity
IS503_RS04460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IS503_RS04470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IS503_RS04470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IS503_RS04475	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS503_RS04480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS503_RS04510	COG4656	Part of a membrane complex involved in electron transport
IS503_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS04515	COG1454	alcohol dehydrogenase
IS503_RS04545	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IS503_RS04710	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IS503_RS04715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IS503_RS04720	COG2166	iron-sulfur cluster assembly
IS503_RS04725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS503_RS04735	COG0583	DNA-binding transcription factor activity
IS503_RS04740	COG2363	Small membrane protein
IS503_RS04750	COG1349	DNA-binding transcription factor activity
IS503_RS04770	COG0738	Major facilitator superfamily
IS503_RS04775	COG0235	Class ii aldolase
IS503_RS04780	COG1454	alcohol dehydrogenase
IS503_RS04800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS503_RS04815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS503_RS04820	COG2011	ABC-type metal ion transport system permease component
IS503_RS04825	COG1464	Belongs to the NlpA lipoprotein family
IS503_RS04830	COG0477	Major facilitator Superfamily
IS503_RS04840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS503_RS04845	COG1760	l-serine dehydratase
IS503_RS04850	COG0814	amino acid
IS503_RS04855	COG1611	Belongs to the LOG family
IS503_RS04870	COG3098	single-species biofilm formation
IS503_RS04875	COG0564	pseudouridine synthase activity
IS503_RS04880	COG0716	FMN binding
IS503_RS04885	COG2271	Major facilitator Superfamily
IS503_RS04890	COG4948	Mandelate Racemase Muconate Lactonizing
IS503_RS04895	COG4948	Mandelate Racemase Muconate Lactonizing
IS503_RS04900	COG1929	Belongs to the glycerate kinase type-1 family
IS503_RS04905	COG4999	Histidine kinase
IS503_RS04905	COG3850	Histidine kinase
IS503_RS04905	COG3437	response regulator, receiver
IS503_RS04905	COG2205	protein histidine kinase activity
IS503_RS04915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS503_RS04920	COG3956	TIGRFAM MazG family protein
IS503_RS04940	COG0602	queuosine metabolic process
IS503_RS04945	COG0720	synthase
IS503_RS04965	COG2234	aminopeptidase activity
IS503_RS05025	COG4942	peptidase
IS503_RS05025	COG1388	LysM domain
IS503_RS05030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS503_RS05055	COG0163	prenyltransferase activity
IS503_RS05060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS503_RS05085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS05090	COG4558	Periplasmic binding protein
IS503_RS05095	COG3720	iron ion transport
IS503_RS05115	COG0679	Auxin Efflux Carrier
IS503_RS05130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS503_RS05135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS503_RS05140	COG1121	(ABC) transporter
IS503_RS05150	COG1609	Transcriptional regulator
IS503_RS05155	COG1940	carbohydrate kinase activity
IS503_RS05160	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS503_RS05165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS05170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS05175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS05180	COG4580	involved in the transport of maltose and maltodextrins
IS503_RS05190	COG2723	6-phospho-beta-galactosidase activity
IS503_RS05200	COG0309	Hydrogenase expression formation protein (HypE)
IS503_RS05205	COG0409	Hydrogenase expression formation protein
IS503_RS05210	COG0298	carbon dioxide binding
IS503_RS05215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IS503_RS05230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS503_RS05235	COG0651	ATP synthesis coupled electron transport
IS503_RS05240	COG0650	Formate hydrogenlyase subunit 4
IS503_RS05245	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IS503_RS05245	COG3261	NADH dehydrogenase
IS503_RS05250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS503_RS05255	COG3260	NADH ubiquinone oxidoreductase 20
IS503_RS05265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IS503_RS05275	COG2723	6-phospho-beta-galactosidase activity
IS503_RS05280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS05280	COG1263	PTS System
IS503_RS05285	COG1609	Transcriptional regulator
IS503_RS05290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS503_RS05295	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IS503_RS05300	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IS503_RS05325	COG1349	DNA-binding transcription factor activity
IS503_RS05330	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS05345	COG3732	PTS system glucitol sorbitol-specific
IS503_RS05350	COG3730	PTS system glucitol sorbitol-specific
IS503_RS05355	COG2951	lytic endotransglycosylase activity
IS503_RS05360	COG1121	(ABC) transporter
IS503_RS05365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS503_RS05375	COG1546	Belongs to the CinA family
IS503_RS05395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IS503_RS05420	COG2823	Periplasmic or secreted lipoprotein
IS503_RS05425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS503_RS05430	COG1238	metal cluster binding
IS503_RS05450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IS503_RS05455	COG2814	Major facilitator Superfamily
IS503_RS05460	COG1566	PFAM secretion protein HlyD family protein
IS503_RS05465	COG1846	Transcriptional regulator
IS503_RS05475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IS503_RS05485	COG4176	ABC-type proline glycine betaine transport system permease component
IS503_RS05500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS503_RS05510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS503_RS05515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS503_RS05520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS503_RS05525	COG4575	ribosome binding
IS503_RS05540	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS503_RS05555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS503_RS05560	COG0640	Transcriptional regulator
IS503_RS05570	COG0583	DNA-binding transcription factor activity
IS503_RS05575	COG3284	Transcriptional regulator
IS503_RS05585	COG3539	Fimbrial protein
IS503_RS05590	COG3121	Chaperone
IS503_RS05610	COG3188	usher protein
IS503_RS05625	COG2197	response regulator
IS503_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS05650	COG0235	Class ii aldolase
IS503_RS05660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS05690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS503_RS05740	COG0431	NADPH-dependent FMN reductase
IS503_RS05755	COG2271	Major facilitator Superfamily
IS503_RS05760	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IS503_RS05765	COG0477	Major facilitator Superfamily
IS503_RS05770	COG3622	Belongs to the hyi family
IS503_RS05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS05800	COG3708	Transcriptional regulator
IS503_RS05800	COG2207	Transcriptional regulator
IS503_RS05830	COG2867	negative regulation of translational initiation
IS503_RS05845	COG0497	DNA recombination
IS503_RS05860	COG4536	flavin adenine dinucleotide binding
IS503_RS05865	COG4137	Cytochrome C assembly protein
IS503_RS05870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IS503_RS05905	COG2885	chlorophyll binding
IS503_RS05910	COG2199	diguanylate cyclase activity
IS503_RS05920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS503_RS05925	COG1605	Chorismate mutase
IS503_RS05925	COG0287	Prephenate dehydrogenase
IS503_RS05935	COG0077	Prephenate dehydratase
IS503_RS05935	COG1605	Chorismate mutase
IS503_RS05945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS503_RS05950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS503_RS05965	COG0542	response to heat
IS503_RS05990	COG0477	Major facilitator Superfamily
IS503_RS05995	COG5544	Lipoprotein
IS503_RS06000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS503_RS06010	COG3148	PFAM DTW domain containing protein
IS503_RS06015	COG3118	belongs to the thioredoxin family
IS503_RS06020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS503_RS06035	COG0513	Belongs to the DEAD box helicase family
IS503_RS06045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IS503_RS06060	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IS503_RS06065	COG3026	antisigma factor binding
IS503_RS06070	COG3086	response to oxidative stress
IS503_RS06080	COG0681	Belongs to the peptidase S26 family
IS503_RS06100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS503_RS06110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS503_RS06115	COG1737	Transcriptional regulator
IS503_RS06120	COG0560	Phosphoserine phosphatase
IS503_RS06135	COG0047	phosphoribosylformylglycinamidine synthase activity
IS503_RS06135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IS503_RS06140	COG2205	protein histidine kinase activity
IS503_RS06145	COG3170	Tfp pilus assembly protein FimV
IS503_RS06150	COG2204	response regulator
IS503_RS06155	COG0347	Belongs to the P(II) protein family
IS503_RS06160	COG1017	nitric oxide dioxygenase activity
IS503_RS06160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS503_RS06170	COG2259	Doxx family
IS503_RS06180	COG0457	Tetratricopeptide repeat
IS503_RS06185	COG2814	Major facilitator Superfamily
IS503_RS06185	COG0477	Major facilitator Superfamily
IS503_RS06190	COG2017	converts alpha-aldose to the beta-anomer
IS503_RS06195	COG2814	Major facilitator Superfamily
IS503_RS06200	COG3711	transcriptional antiterminator
IS503_RS06205	COG3683	transport system, periplasmic component
IS503_RS06210	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS503_RS06240	COG0822	iron-sulfur transferase activity
IS503_RS06260	COG0633	Ferredoxin
IS503_RS06265	COG2975	iron-sulfur cluster assembly
IS503_RS06285	COG2897	thiosulfate sulfurtransferase activity
IS503_RS06290	COG2373	Large extracellular alpha-helical protein
IS503_RS06295	COG4953	penicillin-binding protein 1C
IS503_RS06325	COG2976	Protein conserved in bacteria
IS503_RS06345	COG1645	bacterial-type flagellum-dependent swarming motility
IS503_RS06355	COG0517	IMP dehydrogenase activity
IS503_RS06355	COG0516	GMP reductase activity
IS503_RS06400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS503_RS06430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IS503_RS06490	COG5484	DNA packaging
IS503_RS06490	COG3728	DNA packaging
IS503_RS06625	COG3119	arylsulfatase activity
IS503_RS06630	COG0641	radical SAM
IS503_RS06650	COG2200	EAL domain
IS503_RS06665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IS503_RS06680	COG2723	6-phospho-beta-galactosidase activity
IS503_RS06690	COG2233	PERMEase
IS503_RS06705	COG1393	Belongs to the ArsC family
IS503_RS06710	COG4783	chaperone-mediated protein folding
IS503_RS06720	COG0628	permease
IS503_RS06725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IS503_RS06730	COG2716	regulation of RNA biosynthetic process
IS503_RS06740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IS503_RS06750	COG2321	neutral zinc metallopeptidase
IS503_RS06755	COG1444	tRNA N-acetyltransferase activity
IS503_RS06760	COG0400	carboxylic ester hydrolase activity
IS503_RS06775	COG1393	Belongs to the ArsC family
IS503_RS06785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS503_RS06790	COG0493	'glutamate synthase
IS503_RS06790	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS503_RS06800	COG5342	invasion associated locus B
IS503_RS06805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS503_RS06810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS503_RS06820	COG4810	utilization protein
IS503_RS06910	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS503_RS06930	COG2837	iron assimilation
IS503_RS06940	COG4150	thiosulfate binding
IS503_RS06945	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IS503_RS06950	COG4208	sulfate ABC transporter
IS503_RS06955	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IS503_RS06965	COG4319	ketosteroid isomerase
IS503_RS07000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IS503_RS07020	COG3530	Putative quorum-sensing-regulated virulence factor
IS503_RS07025	COG0385	Bile acid
IS503_RS07030	COG0583	DNA-binding transcription factor activity
IS503_RS07065	COG3415	Transposase
IS503_RS07070	COG3415	Transposase
IS503_RS07085	COG2199	diguanylate cyclase activity
IS503_RS07085	COG2200	EAL domain
IS503_RS07090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS503_RS07105	COG0667	Aldo Keto reductase
IS503_RS07110	COG3961	Belongs to the TPP enzyme family
IS503_RS07125	COG3279	Response regulator of the LytR AlgR family
IS503_RS07130	COG3275	phosphorelay sensor kinase activity
IS503_RS07145	COG0436	Aminotransferase
IS503_RS07155	COG2807	transmembrane transport
IS503_RS07160	COG0590	tRNA wobble adenosine to inosine editing
IS503_RS07165	COG0583	DNA-binding transcription factor activity
IS503_RS07185	COG2116	formate transmembrane transporter activity
IS503_RS07190	COG2853	Lipoprotein
IS503_RS07200	COG3691	Protein conserved in bacteria
IS503_RS07215	COG2062	phosphohistidine phosphatase, SixA
IS503_RS07240	COG0730	response to heat
IS503_RS07245	COG3101	peptidyl-lysine hydroxylation
IS503_RS07260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS503_RS07280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS503_RS07290	COG0586	Pfam SNARE associated Golgi protein
IS503_RS07300	COG0285	dihydrofolate synthase activity
IS503_RS07305	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IS503_RS07310	COG1286	toxin biosynthetic process
IS503_RS07315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IS503_RS07320	COG0163	prenyltransferase activity
IS503_RS07345	COG4160	amino acid transport
IS503_RS07350	COG4598	ABC transporter
IS503_RS07365	COG1090	epimerase
IS503_RS07370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS503_RS07375	COG0625	glutathione transferase activity
IS503_RS07380	COG0625	glutathione transferase activity
IS503_RS07385	COG0622	Phosphoesterase
IS503_RS07390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IS503_RS07395	COG0280	phosphate acetyltransferase
IS503_RS07395	COG0857	belongs to the CobB CobQ family
IS503_RS07415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS503_RS07420	COG0490	domain, Protein
IS503_RS07420	COG0471	metal ion transport
IS503_RS07430	COG0436	Aminotransferase
IS503_RS07435	COG0583	DNA-binding transcription factor activity
IS503_RS07480	COG0839	Belongs to the complex I subunit 6 family
IS503_RS07490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IS503_RS07495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS503_RS07510	COG2153	protein acetylation
IS503_RS07515	COG1169	isochorismate synthase
IS503_RS07540	COG0318	PFAM AMP-dependent synthetase and ligase
IS503_RS07565	COG1414	Transcriptional regulator
IS503_RS07575	COG2271	Major facilitator Superfamily
IS503_RS07585	COG0247	lactate metabolic process
IS503_RS07595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS503_RS07600	COG2271	Major facilitator Superfamily
IS503_RS07605	COG0584	glycerophosphoryl diester phosphodiesterase
IS503_RS07610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS503_RS07635	COG2205	protein histidine kinase activity
IS503_RS07635	COG0784	Response regulator, receiver
IS503_RS07645	COG2198	Histidine kinase
IS503_RS07645	COG0642	Histidine kinase
IS503_RS07660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS503_RS07660	COG2169	Transcriptional regulator
IS503_RS07665	COG3145	DNA-N1-methyladenine dioxygenase activity
IS503_RS07670	COG4615	Cyclic peptide transporter
IS503_RS07675	COG2239	Acts as a magnesium transporter
IS503_RS07680	COG0659	secondary active sulfate transmembrane transporter activity
IS503_RS07695	COG0628	permease
IS503_RS07720	COG1349	DNA-binding transcription factor activity
IS503_RS07725	COG0494	nUDIX hydrolase
IS503_RS07745	COG1061	Type III restriction enzyme res subunit
IS503_RS07750	COG1187	pseudouridine synthase activity
IS503_RS07755	COG2814	Major facilitator Superfamily
IS503_RS07765	COG4172	Belongs to the ABC transporter superfamily
IS503_RS07770	COG4239	(ABC) transporter, permease
IS503_RS07775	COG4174	ABC transporter (Permease)
IS503_RS07780	COG4166	transmembrane transport
IS503_RS07785	COG2200	EAL domain
IS503_RS07790	COG0791	NLP P60 protein
IS503_RS07795	COG0671	phosphoesterase, PA-phosphatase related
IS503_RS07800	COG0523	cobalamin synthesis protein
IS503_RS07805	COG0246	Mannitol dehydrogenase
IS503_RS07810	COG1312	Catalyzes the dehydration of D-mannonate
IS503_RS07825	COG2814	Major facilitator Superfamily
IS503_RS07830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS07830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS07835	COG1105	Belongs to the carbohydrate kinase PfkB family
IS503_RS07840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS503_RS07840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS07840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS07850	COG2855	membrane
IS503_RS07855	COG0583	DNA-binding transcription factor activity
IS503_RS07860	COG0833	amino acid
IS503_RS07865	COG4771	TonB-dependent receptor
IS503_RS07880	COG2311	Membrane
IS503_RS07895	COG1129	ABC transporter
IS503_RS07905	COG2949	membrane
IS503_RS07915	COG1346	cytolysis
IS503_RS07925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS503_RS07930	COG3659	wide pore channel activity
IS503_RS07945	COG2723	6-phospho-beta-galactosidase activity
IS503_RS07950	COG1538	Outer membrane efflux protein
IS503_RS07955	COG0586	Pfam SNARE associated Golgi protein
IS503_RS07965	COG1686	Belongs to the peptidase S11 family
IS503_RS07975	COG0277	FAD linked oxidase domain protein
IS503_RS07980	COG1472	Belongs to the glycosyl hydrolase 3 family
IS503_RS07985	COG1732	Glycine betaine
IS503_RS07990	COG1174	glycine betaine transport
IS503_RS07995	COG1125	glycine betaine transport
IS503_RS08000	COG1174	glycine betaine transport
IS503_RS08010	COG3275	phosphorelay sensor kinase activity
IS503_RS08020	COG4807	Protein conserved in bacteria
IS503_RS08040	COG5455	response to cobalt ion
IS503_RS08045	COG0583	DNA-binding transcription factor activity
IS503_RS08050	COG2252	PERMEase
IS503_RS08060	COG0583	DNA-binding transcription factor activity
IS503_RS08065	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IS503_RS08100	COG0351	phosphomethylpyrimidine kinase
IS503_RS08105	COG1830	Aldolase
IS503_RS08140	COG1070	Carbohydrate kinase
IS503_RS08150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS503_RS08155	COG4948	Mandelate Racemase Muconate Lactonizing
IS503_RS08160	COG0747	negative chemotaxis
IS503_RS08165	COG0601	transmembrane transport
IS503_RS08170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS08175	COG0444	Belongs to the ABC transporter superfamily
IS503_RS08180	COG4608	Belongs to the ABC transporter superfamily
IS503_RS08190	COG0826	peptidase U32
IS503_RS08195	COG0745	RESPONSE REGULATOR receiver
IS503_RS08200	COG2205	protein histidine kinase activity
IS503_RS08225	COG1301	dicarboxylic acid transport
IS503_RS08245	COG5002	protein histidine kinase activity
IS503_RS08250	COG0443	Heat shock 70 kDa protein
IS503_RS08255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IS503_RS08270	COG2982	Protein involved in outer membrane biogenesis
IS503_RS08275	COG1253	flavin adenine dinucleotide binding
IS503_RS08330	COG0110	maltose O-acetyltransferase activity
IS503_RS08335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IS503_RS08340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS503_RS08345	COG1051	belongs to the nudix hydrolase family
IS503_RS08350	COG0297	glycogen (starch) synthase activity
IS503_RS08415	COG0438	transferase activity, transferring glycosyl groups
IS503_RS08420	COG1216	Glycosyl transferase, family 2
IS503_RS08420	COG1442	glycosyl transferase family 8
IS503_RS08430	COG0463	Glycosyl transferase, family 2
IS503_RS08455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IS503_RS08485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS503_RS08490	COG0583	DNA-binding transcription factor activity
IS503_RS08500	COG0531	amino acid
IS503_RS08505	COG0640	Transcriptional regulator
IS503_RS08510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS503_RS08520	COG2925	Exonuclease
IS503_RS08535	COG1289	transmembrane transporter activity
IS503_RS08555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IS503_RS08565	COG1942	4-Oxalocrotonate Tautomerase
IS503_RS08570	COG0583	DNA-binding transcription factor activity
IS503_RS08575	COG0095	Lipoate-protein ligase
IS503_RS08580	COG0477	Major facilitator Superfamily
IS503_RS08590	COG5001	Diguanylate cyclase
IS503_RS08590	COG3300	MHYT domain
IS503_RS08600	COG3615	Tellurite resistance protein tehB
IS503_RS08625	COG3706	GGDEF domain
IS503_RS08655	COG2197	response regulator
IS503_RS08670	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS503_RS08675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IS503_RS08680	COG1960	acyl-CoA dehydrogenase activity
IS503_RS08710	COG0154	amidase activity
IS503_RS08735	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IS503_RS08795	COG4771	TonB-dependent receptor
IS503_RS08800	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS503_RS08820	COG3433	isochorismatase activity
IS503_RS08820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS503_RS08820	COG2226	methyltransferase
IS503_RS08835	COG1132	(ABC) transporter
IS503_RS08840	COG2814	Major facilitator Superfamily
IS503_RS08845	COG1169	isochorismate synthase
IS503_RS08850	COG0582	viral genome integration into host DNA
IS503_RS08865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS08870	COG0735	belongs to the Fur family
IS503_RS08880	COG0523	cobalamin synthesis protein
IS503_RS08905	COG0523	cobalamin synthesis protein
IS503_RS08935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS503_RS08940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS503_RS08945	COG1121	(ABC) transporter
IS503_RS08950	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS503_RS08955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IS503_RS08965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IS503_RS08995	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS503_RS09000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS503_RS09005	COG1121	(ABC) transporter
IS503_RS09015	COG0582	viral genome integration into host DNA
IS503_RS09025	COG0534	Mate efflux family protein
IS503_RS09035	COG0582	viral genome integration into host DNA
IS503_RS09070	COG2994	toxin metabolic process
IS503_RS09095	COG2264	protein methyltransferase activity
IS503_RS09120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IS503_RS09140	COG0604	alcohol dehydrogenase
IS503_RS09145	COG1309	transcriptional regulator
IS503_RS09150	COG0025	NhaP-type Na H and K H
IS503_RS09170	COG1376	ErfK ybiS ycfS ynhG family protein
IS503_RS09185	COG0251	oxidation-reduction process
IS503_RS09205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS503_RS09215	COG1418	mRNA catabolic process
IS503_RS09220	COG0270	DNA (cytosine-5-)-methyltransferase activity
IS503_RS09225	COG3727	T/G mismatch-specific endonuclease activity
IS503_RS09230	COG0697	spore germination
IS503_RS09235	COG2354	Protein conserved in bacteria
IS503_RS09265	COG0366	Alpha amylase catalytic
IS503_RS09270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS09280	COG0765	amino acid transport
IS503_RS09285	COG1126	abc transporter atp-binding protein
IS503_RS09290	COG2197	response regulator
IS503_RS09300	COG2197	response regulator
IS503_RS09335	COG3012	SEC-C Motif Domain Protein
IS503_RS09335	COG3318	Belongs to the UPF0149 family
IS503_RS09340	COG0814	amino acid
IS503_RS09350	COG1528	Iron-storage protein
IS503_RS09365	COG0477	Major facilitator Superfamily
IS503_RS09375	COG2211	Major facilitator Superfamily
IS503_RS09385	COG1528	Iron-storage protein
IS503_RS09395	COG1879	ABC-type sugar transport system periplasmic component
IS503_RS09405	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS09430	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IS503_RS09440	COG3102	Protein conserved in bacteria
IS503_RS09460	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IS503_RS09465	COG1801	Protein of unknown function DUF72
IS503_RS09470	COG1335	isochorismatase
IS503_RS09480	COG0494	nUDIX hydrolase
IS503_RS09505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS503_RS09515	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IS503_RS09520	COG0739	heme binding
IS503_RS09525	COG1560	Kdo2-lipid A biosynthetic process
IS503_RS09535	COG1737	Transcriptional regulator
IS503_RS09545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS503_RS09550	COG0129	dihydroxy-acid dehydratase activity
IS503_RS09555	COG0800	Aldolase
IS503_RS09565	COG3141	response to X-ray
IS503_RS09570	COG2979	Protein of unknown function (DUF533)
IS503_RS09575	COG1770	oligopeptidase
IS503_RS09580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS503_RS09590	COG2372	response to copper ion
IS503_RS09595	COG1276	copper resistance
IS503_RS09610	COG2990	Protein conserved in bacteria
IS503_RS09635	COG3008	intermembrane lipid transfer
IS503_RS09640	COG2995	paraquat-inducible protein a
IS503_RS09645	COG1956	GAF domain-containing protein
IS503_RS09665	COG2814	Major facilitator Superfamily
IS503_RS09670	COG1414	Transcriptional regulator
IS503_RS09700	COG0768	penicillin binding
IS503_RS09705	COG2226	methyltransferase
IS503_RS09720	COG3716	PTS system mannose fructose sorbose family IID component
IS503_RS09725	COG3715	PTS system
IS503_RS09730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS09730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS09735	COG1253	flavin adenine dinucleotide binding
IS503_RS09740	COG2200	EAL domain
IS503_RS09745	COG1760	l-serine dehydratase
IS503_RS09765	COG0251	oxidation-reduction process
IS503_RS09770	COG1199	ATP-dependent helicase activity
IS503_RS09780	COG3065	identical protein binding
IS503_RS09790	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IS503_RS09800	COG2894	cell division
IS503_RS09815	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS503_RS09845	COG2719	SpoVR family
IS503_RS09870	COG1619	proteins homologs of microcin C7 resistance protein MccF
IS503_RS09880	COG4774	siderophore transport
IS503_RS09895	COG2308	Evidence 4 Homologs of previously reported genes of
IS503_RS09940	COG0583	DNA-binding transcription factor activity
IS503_RS09945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS503_RS09960	COG1882	Formate acetyltransferase
IS503_RS09995	COG0583	DNA-binding transcription factor activity
IS503_RS10025	COG0583	DNA-binding transcription factor activity
IS503_RS10040	COG3122	Protein conserved in bacteria
IS503_RS10060	COG2885	chlorophyll binding
IS503_RS10090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IS503_RS10105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IS503_RS10170	COG0012	GTP binding
IS503_RS10190	COG0659	secondary active sulfate transmembrane transporter activity
IS503_RS10220	COG2890	protein-(glutamine-N5) methyltransferase activity
IS503_RS10240	COG0387	Pfam Sodium calcium exchanger
IS503_RS10245	COG4572	Cation transport regulator
IS503_RS10250	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IS503_RS10260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IS503_RS10265	COG3707	response regulator
IS503_RS10270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS503_RS10280	COG1116	anion transmembrane transporter activity
IS503_RS10285	COG2146	nitrite reductase [NAD(P)H] activity
IS503_RS10285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS503_RS10290	COG0243	molybdopterin cofactor binding
IS503_RS10295	COG4932	domain protein
IS503_RS10300	COG2197	response regulator
IS503_RS10305	COG3850	Histidine kinase
IS503_RS10310	COG2223	nitrite transmembrane transporter activity
IS503_RS10320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS503_RS10325	COG1140	nitrate reductase beta subunit
IS503_RS10330	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS503_RS10335	COG2181	nitrate reductase activity
IS503_RS10345	COG1522	sequence-specific DNA binding
IS503_RS10380	COG0788	formyltetrahydrofolate deformylase activity
IS503_RS10390	COG1752	Esterase of the alpha-beta hydrolase superfamily
IS503_RS10395	COG0745	RESPONSE REGULATOR receiver
IS503_RS10400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IS503_RS10405	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS503_RS10415	COG1435	thymidine kinase activity
IS503_RS10420	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS10420	COG1454	alcohol dehydrogenase
IS503_RS10430	COG2095	MarC family integral membrane protein
IS503_RS10435	COG4166	transmembrane transport
IS503_RS10440	COG0601	transmembrane transport
IS503_RS10445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS10450	COG0444	Belongs to the ABC transporter superfamily
IS503_RS10460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS503_RS10480	COG2353	YceI-like domain
IS503_RS10490	COG2350	Protein conserved in bacteria
IS503_RS10500	COG3001	Fructosamine kinase
IS503_RS10510	COG1105	Belongs to the carbohydrate kinase PfkB family
IS503_RS10515	COG3137	Salt-induced outer membrane protein
IS503_RS10555	COG0072	phenylalanine-tRNA ligase activity
IS503_RS10555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS503_RS10575	COG0583	DNA-binding transcription factor activity
IS503_RS10595	COG0386	Belongs to the glutathione peroxidase family
IS503_RS10605	COG0791	NLP P60 protein
IS503_RS10615	COG4256	Hemin uptake protein
IS503_RS10620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS503_RS10635	COG0574	Belongs to the PEP-utilizing enzyme family
IS503_RS10635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS503_RS10645	COG0628	permease
IS503_RS10650	COG0247	lactate metabolic process
IS503_RS10650	COG0277	FAD linked oxidase domain protein
IS503_RS10655	COG2050	protein possibly involved in aromatic compounds catabolism
IS503_RS10660	COG2261	transglycosylase associated protein
IS503_RS10685	COG1120	ATPase activity
IS503_RS10690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS10700	COG0583	DNA-binding transcription factor activity
IS503_RS10725	COG1304	FMN binding
IS503_RS10730	COG1309	transcriptional regulator
IS503_RS10750	COG0316	Belongs to the HesB IscA family
IS503_RS10755	COG0719	Fe-S assembly protein
IS503_RS10760	COG0396	ATPase activity
IS503_RS10765	COG0719	Fe-S assembly protein
IS503_RS10780	COG1376	ErfK ybiS ycfS ynhG family protein
IS503_RS10810	COG1309	transcriptional regulator
IS503_RS10815	COG1082	Xylose isomerase domain protein TIM barrel
IS503_RS10815	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IS503_RS10820	COG2271	Major facilitator Superfamily
IS503_RS10825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS503_RS10835	COG1120	ATPase activity
IS503_RS10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS10845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS503_RS10850	COG1414	Transcriptional regulator
IS503_RS10885	COG2814	Major facilitator Superfamily
IS503_RS10905	COG0583	DNA-binding transcription factor activity
IS503_RS10910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS503_RS10930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS503_RS10935	COG1116	anion transmembrane transporter activity
IS503_RS10940	COG4774	siderophore transport
IS503_RS10945	COG1120	ATPase activity
IS503_RS10950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS10955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS10975	COG0765	amino acid transport
IS503_RS10980	COG1126	abc transporter atp-binding protein
IS503_RS11020	COG3383	formate dehydrogenase (NAD+) activity
IS503_RS11025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IS503_RS11065	COG1857	crispr-associated protein
IS503_RS11075	COG1518	maintenance of DNA repeat elements
IS503_RS11080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS503_RS11085	COG3157	Type VI secretion system effector, Hcp
IS503_RS11115	COG4133	protoheme IX ABC transporter activity
IS503_RS11120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS503_RS11125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS503_RS11140	COG1138	Cytochrome C-type biogenesis protein
IS503_RS11145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS503_RS11150	COG4235	cytochrome complex assembly
IS503_RS11150	COG3088	subunit of a heme lyase
IS503_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS11205	COG2610	gluconate transmembrane transporter activity
IS503_RS11210	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS503_RS11220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS503_RS11230	COG0583	DNA-binding transcription factor activity
IS503_RS11255	COG0277	FAD linked oxidase domain protein
IS503_RS11260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS503_RS11290	COG0402	S-adenosylhomocysteine deaminase activity
IS503_RS11345	COG4608	Belongs to the ABC transporter superfamily
IS503_RS11350	COG0444	Belongs to the ABC transporter superfamily
IS503_RS11375	COG0346	lactoylglutathione lyase activity
IS503_RS11380	COG1349	DNA-binding transcription factor activity
IS503_RS11415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IS503_RS11435	COG0300	oxidoreductase activity
IS503_RS11480	COG0307	riboflavin synthase, alpha
IS503_RS11485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS503_RS11490	COG2814	Major facilitator Superfamily
IS503_RS11495	COG0583	DNA-binding transcription factor activity
IS503_RS11510	COG2814	Major facilitator Superfamily
IS503_RS11525	COG0791	NLP P60 protein
IS503_RS11530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS503_RS11540	COG0346	lactoylglutathione lyase activity
IS503_RS11545	COG1902	pentaerythritol trinitrate reductase activity
IS503_RS11550	COG1309	transcriptional regulator
IS503_RS11555	COG3313	Fe-S protein
IS503_RS11560	COG4989	oxidoreductase activity
IS503_RS11565	COG2032	superoxide dismutase activity
IS503_RS11570	COG1289	transmembrane transporter activity
IS503_RS11575	COG1566	PFAM secretion protein HlyD family protein
IS503_RS11590	COG3706	GGDEF domain
IS503_RS11605	COG3895	Periplasmic Protein
IS503_RS11620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IS503_RS11625	COG0625	glutathione transferase activity
IS503_RS11635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IS503_RS11645	COG4659	FMN binding
IS503_RS11680	COG2723	6-phospho-beta-galactosidase activity
IS503_RS11690	COG0673	inositol 2-dehydrogenase activity
IS503_RS11700	COG2814	Major facilitator Superfamily
IS503_RS11720	COG3038	cytochrome b561
IS503_RS11740	COG0583	DNA-binding transcription factor activity
IS503_RS11745	COG3485	protocatechuate 3,4-dioxygenase
IS503_RS11750	COG3485	protocatechuate 3,4-dioxygenase
IS503_RS11755	COG5383	Protein conserved in bacteria
IS503_RS11760	COG2272	Belongs to the type-B carboxylesterase lipase family
IS503_RS11775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS503_RS11780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS503_RS11785	COG1275	C4-dicarboxylate transporter malic acid transport protein
IS503_RS11790	COG0500	methyltransferase
IS503_RS11800	COG0697	spore germination
IS503_RS11805	COG3708	Transcriptional regulator
IS503_RS11805	COG2207	Transcriptional regulator
IS503_RS11810	COG3135	benzoate transporter
IS503_RS11815	COG1396	sequence-specific DNA binding
IS503_RS11825	COG0826	peptidase U32
IS503_RS11845	COG1294	oxidase, subunit
IS503_RS11850	COG1271	oxidase subunit
IS503_RS11855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS503_RS11860	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS503_RS11865	COG3842	ATPase activity
IS503_RS11870	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS503_RS11875	COG1177	transmembrane transport
IS503_RS11880	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS11915	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS11920	COG0747	negative chemotaxis
IS503_RS11930	COG3238	Protein conserved in bacteria
IS503_RS11935	COG1247	-acetyltransferase
IS503_RS11945	COG2130	NADP-dependent
IS503_RS11960	COG3691	Protein conserved in bacteria
IS503_RS11965	COG1228	amidohydrolase
IS503_RS11970	COG4772	TonB-dependent receptor
IS503_RS11995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS503_RS12000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS503_RS12005	COG1473	amidohydrolase
IS503_RS12010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS503_RS12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS12025	COG0765	amino acid transport
IS503_RS12030	COG1126	abc transporter atp-binding protein
IS503_RS12040	COG0625	glutathione transferase activity
IS503_RS12050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS503_RS12055	COG3842	ATPase activity
IS503_RS12060	COG1840	ABC-type Fe3 transport system, periplasmic component
IS503_RS12065	COG1178	ABC-type Fe3 transport system permease component
IS503_RS12070	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IS503_RS12075	COG2181	nitrate reductase activity
IS503_RS12080	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS503_RS12085	COG1140	nitrate reductase beta subunit
IS503_RS12090	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS503_RS12095	COG2223	nitrite transmembrane transporter activity
IS503_RS12110	COG1414	Transcriptional regulator
IS503_RS12115	COG4948	Mandelate Racemase Muconate Lactonizing
IS503_RS12120	COG4829	muconolactone delta-isomerase
IS503_RS12125	COG3485	protocatechuate 3,4-dioxygenase
IS503_RS12135	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IS503_RS12160	COG0437	4 iron, 4 sulfur cluster binding
IS503_RS12165	COG2864	formate dehydrogenase
IS503_RS12180	COG2326	polyphosphate kinase activity
IS503_RS12190	COG2814	Major facilitator Superfamily
IS503_RS12200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS503_RS12210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS12220	COG0747	negative chemotaxis
IS503_RS12225	COG1064	alcohol dehydrogenase
IS503_RS12240	COG0488	(ABC) transporter
IS503_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS12285	COG3729	General stress protein
IS503_RS12295	COG3685	Protein conserved in bacteria
IS503_RS12305	COG0366	Alpha amylase catalytic
IS503_RS12315	COG2323	membrane
IS503_RS12325	COG3111	PFAM Bacterial OB fold (BOF) protein
IS503_RS12335	COG1764	response to oxidative stress
IS503_RS12360	COG3781	membrane
IS503_RS12365	COG0243	molybdopterin cofactor binding
IS503_RS12370	COG0583	DNA-binding transcription factor activity
IS503_RS12400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS12405	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS503_RS12410	COG2814	Major facilitator Superfamily
IS503_RS12415	COG1285	pathogenesis
IS503_RS12420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS503_RS12430	COG0583	DNA-binding transcription factor activity
IS503_RS12450	COG0519	Catalyzes the synthesis of GMP from XMP
IS503_RS12450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS503_RS12490	COG0596	Alpha beta hydrolase
IS503_RS12500	COG2205	protein histidine kinase activity
IS503_RS12515	COG0076	glutamate decarboxylase activity
IS503_RS12520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS503_RS12525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS503_RS12530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS503_RS12535	COG1116	anion transmembrane transporter activity
IS503_RS12540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IS503_RS12555	COG0673	inositol 2-dehydrogenase activity
IS503_RS12565	COG1609	Transcriptional regulator
IS503_RS12570	COG3706	GGDEF domain
IS503_RS12575	COG0402	S-adenosylhomocysteine deaminase activity
IS503_RS12580	COG1953	Uracil, thiamine, allantoin
IS503_RS12615	COG0596	Alpha beta hydrolase
IS503_RS12625	COG2207	Transcriptional regulator
IS503_RS12640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS503_RS12665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS503_RS12710	COG0765	amino acid transport
IS503_RS12720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IS503_RS12730	COG2070	2-Nitropropane dioxygenase
IS503_RS12735	COG0583	DNA-binding transcription factor activity
IS503_RS12745	COG1902	pentaerythritol trinitrate reductase activity
IS503_RS12750	COG4529	Protein conserved in bacteria
IS503_RS12755	COG0477	Major facilitator Superfamily
IS503_RS12785	COG2223	nitrite transmembrane transporter activity
IS503_RS12795	COG1609	Transcriptional regulator
IS503_RS12800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS12810	COG3037	sugar-specific permease SgaT UlaA
IS503_RS12815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS503_RS12825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS12845	COG0583	DNA-binding transcription factor activity
IS503_RS12850	COG0583	DNA-binding transcription factor activity
IS503_RS12855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS503_RS12865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS503_RS12875	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS12885	COG1609	Transcriptional regulator
IS503_RS12915	COG1652	LysM domain
IS503_RS12940	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IS503_RS12940	COG0456	acetyltransferase
IS503_RS12950	COG0667	Aldo Keto reductase
IS503_RS12965	COG1349	DNA-binding transcription factor activity
IS503_RS12980	COG1349	DNA-binding transcription factor activity
IS503_RS12985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS503_RS12990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS503_RS12995	COG0738	Major facilitator superfamily
IS503_RS13040	COG1929	Belongs to the glycerate kinase type-1 family
IS503_RS13045	COG3835	regulator
IS503_RS13065	COG2186	Transcriptional regulator
IS503_RS13070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS13070	COG1263	PTS System
IS503_RS13080	COG2814	Major facilitator Superfamily
IS503_RS13085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS13085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS13100	COG2819	hydrolase of the alpha beta superfamily
IS503_RS13105	COG3300	MHYT domain
IS503_RS13105	COG5001	Diguanylate cyclase
IS503_RS13140	COG3188	usher protein
IS503_RS13150	COG1649	PFAM Uncharacterised BCR, COG1649
IS503_RS13155	COG3550	peptidyl-serine autophosphorylation
IS503_RS13160	COG1396	sequence-specific DNA binding
IS503_RS13165	COG2351	hydroxyisourate hydrolase activity
IS503_RS13170	COG3195	allantoin biosynthetic process
IS503_RS13170	COG3648	Uricase
IS503_RS13175	COG2233	PERMEase
IS503_RS13205	COG2207	Transcriptional regulator
IS503_RS13240	COG2011	ABC-type metal ion transport system permease component
IS503_RS13245	COG2070	2-Nitropropane dioxygenase
IS503_RS13255	COG0477	Major facilitator Superfamily
IS503_RS13325	COG2199	diguanylate cyclase activity
IS503_RS13340	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS13345	COG0583	DNA-binding transcription factor activity
IS503_RS13355	COG0039	L-malate dehydrogenase activity
IS503_RS13360	COG1349	DNA-binding transcription factor activity
IS503_RS13365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS503_RS13370	COG3395	kinase activity
IS503_RS13380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS503_RS13385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS503_RS13390	COG2271	Major facilitator Superfamily
IS503_RS13420	COG4977	sequence-specific DNA binding
IS503_RS13430	COG0697	spore germination
IS503_RS13435	COG2814	Major facilitator Superfamily
IS503_RS13470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IS503_RS13505	COG2223	nitrite transmembrane transporter activity
IS503_RS13510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IS503_RS13525	COG1349	DNA-binding transcription factor activity
IS503_RS13530	COG2084	Dehydrogenase
IS503_RS13535	COG3395	kinase activity
IS503_RS13540	COG0235	Class ii aldolase
IS503_RS13545	COG3622	Belongs to the hyi family
IS503_RS13550	COG2610	gluconate transmembrane transporter activity
IS503_RS13570	COG2200	EAL domain
IS503_RS13575	COG1546	Belongs to the CinA family
IS503_RS13580	COG0071	Belongs to the small heat shock protein (HSP20) family
IS503_RS13595	COG2197	response regulator
IS503_RS13610	COG2135	peptidase activity
IS503_RS13615	COG2207	Transcriptional regulator
IS503_RS13630	COG4221	oxidoreductase activity
IS503_RS13635	COG1802	Transcriptional regulator
IS503_RS13640	COG0589	response to stress
IS503_RS13645	COG0246	Mannitol dehydrogenase
IS503_RS13650	COG2271	Major facilitator Superfamily
IS503_RS13665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS503_RS13680	COG0243	molybdopterin cofactor binding
IS503_RS13685	COG0437	4 iron, 4 sulfur cluster binding
IS503_RS13690	COG3302	dmso reductase anchor subunit
IS503_RS13705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IS503_RS13710	COG1940	carbohydrate kinase activity
IS503_RS13715	COG0583	DNA-binding transcription factor activity
IS503_RS13720	COG2814	Major facilitator Superfamily
IS503_RS13725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IS503_RS13735	COG3591	Belongs to the peptidase S1B family
IS503_RS13755	COG0628	permease
IS503_RS13785	COG0679	Auxin Efflux Carrier
IS503_RS13795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS503_RS13820	COG3290	protein histidine kinase activity
IS503_RS13825	COG4565	transcriptional regulatory protein
IS503_RS13845	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS503_RS13845	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS503_RS13855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS503_RS13860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS503_RS13870	COG0183	Belongs to the thiolase family
IS503_RS13875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS503_RS13885	COG1414	Transcriptional regulator
IS503_RS13890	COG2840	Smr protein MutS2
IS503_RS13895	COG0583	DNA-binding transcription factor activity
IS503_RS13905	COG1473	amidohydrolase
IS503_RS13910	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IS503_RS13925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS503_RS13940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IS503_RS13945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IS503_RS13960	COG0531	amino acid
IS503_RS13970	COG3136	membrane protein required for alginate biosynthesis
IS503_RS13975	COG0745	RESPONSE REGULATOR receiver
IS503_RS13985	COG2205	protein histidine kinase activity
IS503_RS13995	COG0114	fumarate hydratase activity
IS503_RS14000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS503_RS14000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS503_RS14005	COG1482	cell wall glycoprotein biosynthetic process
IS503_RS14010	COG5339	Protein conserved in bacteria
IS503_RS14015	COG1609	Transcriptional regulator
IS503_RS14020	COG1263	PTS System
IS503_RS14020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS14025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS503_RS14050	COG2391	methyltransferase activity
IS503_RS14055	COG0425	Belongs to the sulfur carrier protein TusA family
IS503_RS14060	COG5562	phage envelope protein
IS503_RS14065	COG0401	homolog of Blt101
IS503_RS14070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS503_RS14075	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS14085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS503_RS14090	COG0477	Major facilitator Superfamily
IS503_RS14095	COG1113	amino acid transport
IS503_RS14100	COG2988	succinylglutamate desuccinylase activity
IS503_RS14105	COG3724	N-succinylarginine dihydrolase activity
IS503_RS14110	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS14115	COG3138	arginine N-succinyltransferase
IS503_RS14120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS503_RS14130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS503_RS14135	COG0667	Aldo Keto reductase
IS503_RS14140	COG0583	DNA-binding transcription factor activity
IS503_RS14165	COG4122	O-methyltransferase activity
IS503_RS14170	COG1643	Atp-dependent helicase
IS503_RS14185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS503_RS14190	COG3327	negative regulation of DNA-templated transcription, initiation
IS503_RS14195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IS503_RS14200	COG0183	Belongs to the thiolase family
IS503_RS14205	COG2050	protein possibly involved in aromatic compounds catabolism
IS503_RS14210	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS503_RS14215	COG1024	Enoyl-CoA hydratase
IS503_RS14220	COG1024	Enoyl-CoA hydratase
IS503_RS14225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS503_RS14230	COG2151	metal-sulfur cluster biosynthetic enzyme
IS503_RS14235	COG3396	Phenylacetate-CoA oxygenase
IS503_RS14240	COG3460	Phenylacetate-CoA oxygenase
IS503_RS14245	COG3396	Phenylacetate-CoA oxygenase
IS503_RS14250	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS14250	COG2030	dehydratase
IS503_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS14275	COG2207	Transcriptional regulator
IS503_RS14280	COG3784	Protein of unknown function (DUF1318)
IS503_RS14290	COG2911	Protein conserved in bacteria
IS503_RS14295	COG0586	Pfam SNARE associated Golgi protein
IS503_RS14300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS503_RS14305	COG3187	Heat shock protein
IS503_RS14310	COG3042	response to heat
IS503_RS14320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS503_RS14330	COG0589	response to stress
IS503_RS14340	COG0513	Belongs to the DEAD box helicase family
IS503_RS14350	COG1349	DNA-binding transcription factor activity
IS503_RS14355	COG0673	inositol 2-dehydrogenase activity
IS503_RS14370	COG1113	amino acid transport
IS503_RS14375	COG1522	sequence-specific DNA binding
IS503_RS14385	COG1448	Aminotransferase
IS503_RS14390	COG2011	ABC-type metal ion transport system permease component
IS503_RS14405	COG0436	Aminotransferase
IS503_RS14410	COG0604	alcohol dehydrogenase
IS503_RS14440	COG0583	DNA-binding transcription factor activity
IS503_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS14465	COG1309	transcriptional regulator
IS503_RS14470	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS14530	COG2801	Transposase and inactivated derivatives
IS503_RS14535	COG2963	transposase activity
IS503_RS14540	COG2963	transposase activity
IS503_RS14550	COG1388	LysM domain
IS503_RS14550	COG1705	Flagellar rod assembly protein muramidase FlgJ
IS503_RS14575	COG2885	chlorophyll binding
IS503_RS14600	COG0693	protein deglycase activity
IS503_RS14605	COG1078	dGTPase activity
IS503_RS14615	COG0583	DNA-binding transcription factor activity
IS503_RS14675	COG5002	protein histidine kinase activity
IS503_RS14675	COG2205	protein histidine kinase activity
IS503_RS14675	COG0784	Response regulator, receiver
IS503_RS14680	COG3250	beta-galactosidase activity
IS503_RS14685	COG0656	L-ascorbic acid biosynthetic process
IS503_RS14750	COG4166	transmembrane transport
IS503_RS14760	COG2866	Carboxypeptidase
IS503_RS14765	COG4948	Mandelate Racemase Muconate Lactonizing
IS503_RS14770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IS503_RS14775	COG3180	Ammonia monooxygenase
IS503_RS14785	COG1486	melibiose metabolic process
IS503_RS14790	COG0583	DNA-binding transcription factor activity
IS503_RS14800	COG3106	COG3106 Predicted ATPase
IS503_RS14810	COG1983	PspC domain protein
IS503_RS14820	COG1842	Phage shock protein A
IS503_RS14825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS503_RS14835	COG1473	amidohydrolase
IS503_RS14850	COG0702	epimerase
IS503_RS14865	COG4171	peptide transport system, permease
IS503_RS14880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS503_RS14890	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS503_RS14895	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS503_RS14895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS503_RS14910	COG1349	DNA-binding transcription factor activity
IS503_RS14920	COG0023	Translation Initiation Factor
IS503_RS14930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IS503_RS14935	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IS503_RS14940	COG0671	phosphoesterase, PA-phosphatase related
IS503_RS14950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IS503_RS14975	COG0616	signal peptide processing
IS503_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS14990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IS503_RS15000	COG0583	DNA-binding transcription factor activity
IS503_RS15010	COG0009	L-threonylcarbamoyladenylate synthase
IS503_RS15020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IS503_RS15025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS503_RS15025	COG0512	Glutamine amidotransferase of anthranilate synthase
IS503_RS15030	COG0135	phosphoribosylanthranilate isomerase activity
IS503_RS15030	COG0134	indole-3-glycerol-phosphate synthase activity
IS503_RS15085	COG4774	siderophore transport
IS503_RS15095	COG3047	cAMP biosynthetic process
IS503_RS15100	COG0727	PFAM Uncharacterised protein family (UPF0153)
IS503_RS15130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS503_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS15140	COG1988	membrane-bound metal-dependent
IS503_RS15145	COG1823	symporter activity
IS503_RS15155	COG0753	catalase activity
IS503_RS15165	COG1486	melibiose metabolic process
IS503_RS15170	COG1917	Cupin 2, conserved barrel domain protein
IS503_RS15170	COG2169	Transcriptional regulator
IS503_RS15175	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS503_RS15180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS15190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS15195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS503_RS15205	COG0322	excinuclease ABC activity
IS503_RS15210	COG3678	ATP-independent chaperone mediated protein folding
IS503_RS15220	COG3724	N-succinylarginine dihydrolase activity
IS503_RS15230	COG3138	arginine N-succinyltransferase
IS503_RS15240	COG0708	Exodeoxyribonuclease III
IS503_RS15245	COG0398	Pfam SNARE associated Golgi protein
IS503_RS15250	COG0398	Pfam SNARE associated Golgi protein
IS503_RS15255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS503_RS15260	COG4134	Bacterial extracellular solute-binding protein
IS503_RS15265	COG4135	transport system, permease component
IS503_RS15270	COG4136	ATPase activity
IS503_RS15275	COG2897	thiosulfate sulfurtransferase activity
IS503_RS15280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS503_RS15285	COG0494	nUDIX hydrolase
IS503_RS15290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS503_RS15295	COG3321	synthase
IS503_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS15295	COG0604	alcohol dehydrogenase
IS503_RS15300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS503_RS15305	COG0709	Synthesizes selenophosphate from selenide and ATP
IS503_RS15315	COG0778	Nitroreductase
IS503_RS15320	COG0616	signal peptide processing
IS503_RS15325	COG0252	asparaginase activity
IS503_RS15330	COG1335	isochorismatase
IS503_RS15345	COG3139	Protein of unknown function (DUF1315)
IS503_RS15365	COG0656	L-ascorbic acid biosynthetic process
IS503_RS15370	COG3713	MltA-interacting MipA family protein
IS503_RS15375	COG2766	serine protein kinase
IS503_RS15390	COG0386	Belongs to the glutathione peroxidase family
IS503_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS15420	COG0583	DNA-binding transcription factor activity
IS503_RS15425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS503_RS15430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS503_RS15440	COG0859	PFAM glycosyl transferase family 9
IS503_RS15445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS503_RS15455	COG2207	Transcriptional regulator
IS503_RS15460	COG2807	transmembrane transport
IS503_RS15465	COG0504	CTP synthase activity
IS503_RS15470	COG1683	Conserved Protein
IS503_RS15475	COG3189	MarR family transcriptional regulator
IS503_RS15480	COG3042	response to heat
IS503_RS15485	COG2203	Gaf domain
IS503_RS15485	COG2199	diguanylate cyclase activity
IS503_RS15505	COG3182	Iron-regulated membrane protein
IS503_RS15515	COG1560	Kdo2-lipid A biosynthetic process
IS503_RS15525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IS503_RS15530	COG3706	GGDEF domain
IS503_RS15535	COG0583	DNA-binding transcription factor activity
IS503_RS15540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS503_RS15570	COG1294	oxidase, subunit
IS503_RS15575	COG1271	oxidase subunit
IS503_RS15580	COG3546	catalase activity
IS503_RS15585	COG3685	Protein conserved in bacteria
IS503_RS15590	COG3685	Protein conserved in bacteria
IS503_RS15595	COG3729	General stress protein
IS503_RS15605	COG1063	alcohol dehydrogenase
IS503_RS15610	COG3813	Protein conserved in bacteria
IS503_RS15630	COG0640	Transcriptional regulator
IS503_RS15635	COG0538	isocitrate dehydrogenase activity
IS503_RS15640	COG5001	Diguanylate cyclase
IS503_RS15640	COG3300	MHYT domain
IS503_RS15645	COG3706	GGDEF domain
IS503_RS15730	COG0616	signal peptide processing
IS503_RS15745	COG4626	Terminase
IS503_RS15745	COG1802	Transcriptional regulator
IS503_RS15790	COG3772	lysozyme
IS503_RS15815	COG1403	HNH endonuclease
IS503_RS15885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS503_RS15895	COG0582	viral genome integration into host DNA
IS503_RS15900	COG0538	isocitrate dehydrogenase activity
IS503_RS15905	COG1187	pseudouridine synthase activity
IS503_RS15925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IS503_RS15945	COG2205	protein histidine kinase activity
IS503_RS15950	COG2850	peptidyl-arginine hydroxylation
IS503_RS15955	COG1943	Transposase
IS503_RS15975	COG1177	transmembrane transport
IS503_RS15990	COG0318	PFAM AMP-dependent synthetase and ligase
IS503_RS15995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS503_RS16000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS503_RS16005	COG0698	ribose 5-phosphate isomerase
IS503_RS16020	COG3395	kinase activity
IS503_RS16035	COG2390	Transcriptional regulator
IS503_RS16045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IS503_RS16055	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS503_RS16065	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS503_RS16075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IS503_RS16080	COG1376	ErfK ybiS ycfS ynhG family protein
IS503_RS16080	COG1388	LysM domain
IS503_RS16095	COG1309	transcriptional regulator
IS503_RS16110	COG3134	Outer membrane lipoprotein
IS503_RS16115	COG1252	NADH dehydrogenase
IS503_RS16140	COG5633	Lipoprotein
IS503_RS16145	COG0537	adenosine 5'-monophosphoramidase activity
IS503_RS16155	COG0084	hydrolase, TatD family'
IS503_RS16160	COG0470	DNA polymerase III
IS503_RS16170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IS503_RS16175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS503_RS16180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS503_RS16195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS503_RS16215	COG1399	metal-binding, possibly nucleic acid-binding protein
IS503_RS16235	COG1530	ribonuclease E activity
IS503_RS16240	COG0583	DNA-binding transcription factor activity
IS503_RS16245	COG2814	Major facilitator Superfamily
IS503_RS16265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS503_RS16310	COG1560	Kdo2-lipid A biosynthetic process
IS503_RS16325	COG5645	(Lipo)protein
IS503_RS16360	COG3381	protein complex oligomerization
IS503_RS16380	COG0583	DNA-binding transcription factor activity
IS503_RS16390	COG1335	isochorismatase
IS503_RS16400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS503_RS16405	COG1702	phosphate starvation-inducible protein PhoH
IS503_RS16425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS503_RS16435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS503_RS16450	COG1309	transcriptional regulator
IS503_RS16485	COG2233	PERMEase
IS503_RS16495	COG3729	General stress protein
IS503_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS16540	COG0531	amino acid
IS503_RS16545	COG0174	glutamine synthetase
IS503_RS16550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IS503_RS16555	COG1396	sequence-specific DNA binding
IS503_RS16555	COG1917	Cupin 2, conserved barrel domain protein
IS503_RS16560	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS16565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS503_RS16570	COG0583	DNA-binding transcription factor activity
IS503_RS16575	COG0473	3-isopropylmalate dehydrogenase activity
IS503_RS16580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS503_RS16585	COG4638	Rieske (2fe-2S)
IS503_RS16590	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS16595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS503_RS16600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS16600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS16600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS503_RS16605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS16610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS16615	COG1882	Formate acetyltransferase
IS503_RS16620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS503_RS16625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS503_RS16635	COG2207	Transcriptional regulator
IS503_RS16640	COG3706	GGDEF domain
IS503_RS16660	COG2200	EAL domain
IS503_RS16670	COG0058	SHG alpha-glucan phosphorylase activity
IS503_RS16685	COG0670	Belongs to the BI1 family
IS503_RS16700	COG2207	Transcriptional regulator
IS503_RS16705	COG1881	PFAM PEBP family protein
IS503_RS16720	COG1832	CoA-binding protein
IS503_RS16730	COG0210	DNA helicase
IS503_RS16735	COG3304	Inner membrane component domain
IS503_RS16740	COG1289	transmembrane transporter activity
IS503_RS16745	COG3070	regulator of competence-specific genes
IS503_RS16770	COG1067	ATP-dependent peptidase activity
IS503_RS16780	COG3130	regulation of translation
IS503_RS16785	COG3009	Protein conserved in bacteria
IS503_RS16790	COG3008	intermembrane lipid transfer
IS503_RS16790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS503_RS16795	COG2995	paraquat-inducible protein a
IS503_RS16800	COG0488	(ABC) transporter
IS503_RS16810	COG3217	Mosc domain protein beta barrel domain protein
IS503_RS16810	COG0633	Ferredoxin
IS503_RS16825	COG0431	NADPH-dependent FMN reductase
IS503_RS16830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS503_RS16835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS503_RS16840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS503_RS16850	COG0308	aminopeptidase N
IS503_RS16860	COG1473	amidohydrolase
IS503_RS16870	COG0814	amino acid
IS503_RS16890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS503_RS16895	COG1448	Aminotransferase
IS503_RS16900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS503_RS16905	COG3108	Peptidase M15
IS503_RS16910	COG2989	Protein conserved in bacteria
IS503_RS16920	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IS503_RS16930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS503_RS16935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS503_RS16940	COG3173	Aminoglycoside phosphotransferase
IS503_RS16955	COG3214	Protein conserved in bacteria
IS503_RS16970	COG2333	competence protein COMEC
IS503_RS16970	COG0658	competence protein
IS503_RS16980	COG0539	negative regulation of cytoplasmic translation
IS503_RS17000	COG2323	membrane
IS503_RS17005	COG1944	ATP diphosphatase activity
IS503_RS17010	COG2116	formate transmembrane transporter activity
IS503_RS17015	COG1882	Formate acetyltransferase
IS503_RS17020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS503_RS17025	COG0477	Major facilitator Superfamily
IS503_RS17030	COG3302	dmso reductase anchor subunit
IS503_RS17035	COG0437	4 iron, 4 sulfur cluster binding
IS503_RS17040	COG0243	molybdopterin cofactor binding
IS503_RS17050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IS503_RS17060	COG1674	ftsk spoiiie
IS503_RS17060	COG1178	ABC-type Fe3 transport system permease component
IS503_RS17070	COG0492	ferredoxin-NADP+ reductase activity
IS503_RS17075	COG4988	ABC transporter
IS503_RS17080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IS503_RS17095	COG0542	response to heat
IS503_RS17105	COG1278	Cold shock
IS503_RS17115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS17120	COG3593	DNA synthesis involved in DNA repair
IS503_RS17130	COG2431	L-lysine efflux transmembrane transporter activity
IS503_RS17140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS503_RS17150	COG0028	Belongs to the TPP enzyme family
IS503_RS17155	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IS503_RS17160	COG0702	epimerase
IS503_RS17165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS503_RS17170	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS503_RS17175	COG2203	Gaf domain
IS503_RS17175	COG3706	GGDEF domain
IS503_RS17175	COG5001	Diguanylate cyclase
IS503_RS17175	COG4251	negative regulation of phosphorylation
IS503_RS17185	COG1126	abc transporter atp-binding protein
IS503_RS17190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS17195	COG4215	(ABC) transporter
IS503_RS17200	COG4160	amino acid transport
IS503_RS17205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS17210	COG5002	protein histidine kinase activity
IS503_RS17215	COG0745	RESPONSE REGULATOR receiver
IS503_RS17230	COG1177	transmembrane transport
IS503_RS17235	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS503_RS17240	COG3842	ATPase activity
IS503_RS17245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS503_RS17260	COG0778	Nitroreductase
IS503_RS17285	COG3226	Transcriptional regulator
IS503_RS17290	COG0738	Major facilitator superfamily
IS503_RS17295	COG0561	phosphatase activity
IS503_RS17300	COG2814	Major facilitator Superfamily
IS503_RS17305	COG0671	phosphoesterase, PA-phosphatase related
IS503_RS17310	COG1349	DNA-binding transcription factor activity
IS503_RS17315	COG1686	Belongs to the peptidase S11 family
IS503_RS17325	COG0625	glutathione transferase activity
IS503_RS17330	COG2133	pyrroloquinoline quinone binding
IS503_RS17340	COG2223	nitrite transmembrane transporter activity
IS503_RS17360	COG0747	negative chemotaxis
IS503_RS17375	COG0303	'Molybdopterin
IS503_RS17380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS503_RS17385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS503_RS17390	COG1882	Formate acetyltransferase
IS503_RS17395	COG0561	phosphatase activity
IS503_RS17405	COG1609	Transcriptional regulator
IS503_RS17410	COG2271	Major facilitator Superfamily
IS503_RS17420	COG0488	(ABC) transporter
IS503_RS17425	COG2365	Tyrosine phosphatase family
IS503_RS17430	COG1376	ErfK ybiS ycfS ynhG family protein
IS503_RS17435	COG2188	Transcriptional regulator
IS503_RS17440	COG2723	6-phospho-beta-galactosidase activity
IS503_RS17445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS503_RS17460	COG2194	sulfuric ester hydrolase activity
IS503_RS17465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IS503_RS17480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS17485	COG0765	amino acid transport
IS503_RS17490	COG1126	abc transporter atp-binding protein
IS503_RS17495	COG0668	transmembrane transport
IS503_RS17505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS503_RS17515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS503_RS17525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS503_RS17530	COG1199	ATP-dependent helicase activity
IS503_RS17535	COG0513	Belongs to the DEAD box helicase family
IS503_RS17540	COG3958	Transketolase
IS503_RS17545	COG3959	Transketolase, thiamine diphosphate binding domain
IS503_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS17555	COG2271	Major facilitator Superfamily
IS503_RS17565	COG0583	DNA-binding transcription factor activity
IS503_RS17570	COG1309	transcriptional regulator
IS503_RS17575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS17580	COG1131	(ABC) transporter
IS503_RS17585	COG0842	Transport permease protein
IS503_RS17590	COG0842	Transport permease protein
IS503_RS17600	COG3568	Endonuclease Exonuclease Phosphatase
IS503_RS17605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS503_RS17610	COG0392	lysyltransferase activity
IS503_RS17615	COG0670	Belongs to the BI1 family
IS503_RS17620	COG0314	molybdopterin synthase activity
IS503_RS17625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IS503_RS17635	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS503_RS17655	COG0745	RESPONSE REGULATOR receiver
IS503_RS17660	COG0642	Histidine kinase
IS503_RS17685	COG2226	methyltransferase
IS503_RS17700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS503_RS17705	COG1881	PFAM PEBP family protein
IS503_RS17745	COG4677	pectinesterase activity
IS503_RS17755	COG0589	response to stress
IS503_RS17760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS17795	COG0789	Transcriptional regulator
IS503_RS17800	COG2200	EAL domain
IS503_RS17825	COG0561	phosphatase activity
IS503_RS17830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IS503_RS17835	COG4149	molybdate abc transporter
IS503_RS17840	COG0725	ABC transporter, periplasmic molybdate-binding protein
IS503_RS17850	COG2005	Transcriptional regulator
IS503_RS17850	COG3585	molybdate ion transport
IS503_RS17855	COG1119	ATPase activity
IS503_RS17865	COG1085	galactose-1-phosphate uridylyltransferase
IS503_RS17875	COG2017	converts alpha-aldose to the beta-anomer
IS503_RS17885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS503_RS17900	COG3201	nicotinamide mononucleotide transporter
IS503_RS17905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IS503_RS17955	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IS503_RS17960	COG2885	chlorophyll binding
IS503_RS17970	COG3064	Membrane
IS503_RS17975	COG0848	biopolymer transport protein
IS503_RS17980	COG0811	peptide transport
IS503_RS17985	COG0824	Thioesterase
IS503_RS17990	COG3790	cyd operon protein YbgE
IS503_RS17995	COG4890	Cyd operon protein YbgT
IS503_RS18000	COG1294	oxidase, subunit
IS503_RS18005	COG1271	oxidase subunit
IS503_RS18010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS503_RS18020	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS503_RS18025	COG0567	Dehydrogenase, E1 component
IS503_RS18030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS503_RS18035	COG1053	succinate dehydrogenase
IS503_RS18040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IS503_RS18045	COG2009	succinate dehydrogenase
IS503_RS18080	COG1984	allophanate hydrolase subunit 2
IS503_RS18085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IS503_RS18100	COG0415	Belongs to the DNA photolyase family
IS503_RS18125	COG2205	protein histidine kinase activity
IS503_RS18130	COG0745	RESPONSE REGULATOR receiver
IS503_RS18140	COG0033	Phosphoglucomutase
IS503_RS18150	COG0596	Alpha beta hydrolase
IS503_RS18165	COG0735	belongs to the Fur family
IS503_RS18205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IS503_RS18210	COG1846	Transcriptional regulator
IS503_RS18210	COG1940	carbohydrate kinase activity
IS503_RS18215	COG0647	UMP catabolic process
IS503_RS18220	COG0367	asparagine synthase
IS503_RS18260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS503_RS18270	COG1702	phosphate starvation-inducible protein PhoH
IS503_RS18295	COG0765	amino acid transport
IS503_RS18300	COG0765	amino acid transport
IS503_RS18305	COG1126	abc transporter atp-binding protein
IS503_RS18320	COG2888	peptidyl-tyrosine sulfation
IS503_RS18335	COG1466	dna polymerase III delta subunit
IS503_RS18350	COG0799	negative regulation of ribosome biogenesis
IS503_RS18360	COG0768	penicillin binding
IS503_RS18365	COG0772	Belongs to the SEDS family
IS503_RS18370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS503_RS18375	COG1686	Belongs to the peptidase S11 family
IS503_RS18390	COG0583	DNA-binding transcription factor activity
IS503_RS18400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IS503_RS18405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS503_RS18425	COG3069	C4-dicarboxylate transmembrane transporter activity
IS503_RS18430	COG3719	Belongs to the RNase T2 family
IS503_RS18435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS503_RS18455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS503_RS18460	COG0583	DNA-binding transcription factor activity
IS503_RS18465	COG3969	phosphoadenosine phosphosulfate
IS503_RS18470	COG1475	DNA binding
IS503_RS18475	COG0436	Aminotransferase
IS503_RS18500	COG1129	ABC transporter
IS503_RS18505	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS18510	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS18520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS503_RS18535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS503_RS18545	COG0402	S-adenosylhomocysteine deaminase activity
IS503_RS18555	COG0483	inositol monophosphate 1-phosphatase activity
IS503_RS18560	COG2271	Major facilitator Superfamily
IS503_RS18590	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS18595	COG1129	ABC transporter
IS503_RS18600	COG0371	Dehydrogenase
IS503_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS18620	COG2879	small protein
IS503_RS18625	COG1966	Carbon starvation protein
IS503_RS18635	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS18640	COG1535	isochorismatase
IS503_RS18640	COG3433	isochorismatase activity
IS503_RS18645	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS503_RS18650	COG1169	isochorismate synthase
IS503_RS18655	COG4592	Periplasmic binding protein
IS503_RS18665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS18670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS18675	COG1120	ATPase activity
IS503_RS18680	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IS503_RS18680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS503_RS18685	COG3251	PFAM MbtH domain protein
IS503_RS18690	COG2382	esterase
IS503_RS18695	COG4771	TonB-dependent receptor
IS503_RS18700	COG2977	Belongs to the P-Pant transferase superfamily
IS503_RS18705	COG3958	Transketolase
IS503_RS18710	COG3959	Transketolase, thiamine diphosphate binding domain
IS503_RS18715	COG2390	Transcriptional regulator
IS503_RS18720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS503_RS18725	COG1879	ABC-type sugar transport system periplasmic component
IS503_RS18735	COG1129	ABC transporter
IS503_RS18740	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS18760	COG0583	DNA-binding transcription factor activity
IS503_RS18765	COG0668	transmembrane transport
IS503_RS18775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS503_RS18800	COG0747	negative chemotaxis
IS503_RS18805	COG0601	transmembrane transport
IS503_RS18810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS18815	COG0444	Belongs to the ABC transporter superfamily
IS503_RS18820	COG4608	Belongs to the ABC transporter superfamily
IS503_RS18830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS503_RS18835	COG4221	oxidoreductase activity
IS503_RS18845	COG4215	(ABC) transporter
IS503_RS18850	COG0765	amino acid transport
IS503_RS18855	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IS503_RS18870	COG0697	spore germination
IS503_RS18885	COG4608	Belongs to the ABC transporter superfamily
IS503_RS18890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS18910	COG3698	Phosphodiester glycosidase
IS503_RS18950	COG2315	Protein conserved in bacteria
IS503_RS18955	COG0778	Nitroreductase
IS503_RS18965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS18975	COG3716	PTS system mannose fructose sorbose family IID component
IS503_RS18980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS503_RS18985	COG2222	sugar isomerase
IS503_RS18990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS503_RS18990	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS503_RS19005	COG0477	Major facilitator Superfamily
IS503_RS19010	COG0668	transmembrane transport
IS503_RS19015	COG1609	Transcriptional regulator
IS503_RS19025	COG0673	inositol 2-dehydrogenase activity
IS503_RS19035	COG2211	Major facilitator Superfamily
IS503_RS19040	COG1113	amino acid transport
IS503_RS19055	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS19060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS503_RS19070	COG0531	amino acid
IS503_RS19115	COG0667	Aldo Keto reductase
IS503_RS19120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS19125	COG1473	amidohydrolase
IS503_RS19155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS19160	COG1120	ATPase activity
IS503_RS19165	COG1566	PFAM secretion protein HlyD family protein
IS503_RS19210	COG4211	Belongs to the binding-protein-dependent transport system permease family
IS503_RS19215	COG1129	ABC transporter
IS503_RS19230	COG0673	inositol 2-dehydrogenase activity
IS503_RS19260	COG3104	oligopeptide transport
IS503_RS19265	COG1982	Orn Lys Arg decarboxylase major
IS503_RS19270	COG0531	amino acid
IS503_RS19275	COG3710	Transcriptional regulator
IS503_RS19285	COG1560	Kdo2-lipid A biosynthetic process
IS503_RS19300	COG3188	usher protein
IS503_RS19305	COG3121	Chaperone
IS503_RS19310	COG3539	Fimbrial protein
IS503_RS19360	COG2501	S4 domain
IS503_RS19365	COG1988	membrane-bound metal-dependent
IS503_RS19385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS503_RS19400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IS503_RS19405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IS503_RS19410	COG0549	Belongs to the carbamate kinase family
IS503_RS19420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS503_RS19425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS503_RS19430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IS503_RS19435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS503_RS19440	COG3257	ureidoglycine aminohydrolase activity
IS503_RS19445	COG1929	Belongs to the glycerate kinase type-1 family
IS503_RS19450	COG2233	PERMEase
IS503_RS19460	COG1953	Uracil, thiamine, allantoin
IS503_RS19470	COG2084	Dehydrogenase
IS503_RS19475	COG3622	Belongs to the hyi family
IS503_RS19480	COG3960	tartronate-semialdehyde synthase activity
IS503_RS19515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IS503_RS19520	COG4181	ATPase activity
IS503_RS19525	COG2755	lipolytic protein G-D-S-L family
IS503_RS19530	COG0300	oxidoreductase activity
IS503_RS19535	COG3118	belongs to the thioredoxin family
IS503_RS19540	COG0390	transport system, permease component
IS503_RS19545	COG4619	ABC transporter
IS503_RS19550	COG0330	HflC and HflK could
IS503_RS19555	COG1585	Membrane protein implicated in regulation of membrane protease activity
IS503_RS19570	COG3735	TraB family
IS503_RS19575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS503_RS19585	COG2223	nitrite transmembrane transporter activity
IS503_RS19590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS503_RS19590	COG4651	solute:proton antiporter activity
IS503_RS19595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS503_RS19635	COG2832	Protein of unknown function (DUF454)
IS503_RS19640	COG3923	Primosomal replication protein n
IS503_RS19655	COG1196	nuclear chromosome segregation
IS503_RS19655	COG3264	Mechanosensitive ion channel
IS503_RS19660	COG1309	transcriptional regulator
IS503_RS19665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS19670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS503_RS19685	COG0110	maltose O-acetyltransferase activity
IS503_RS19735	COG1874	Beta-galactosidase
IS503_RS19740	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IS503_RS19745	COG3833	ABC-type maltose transport systems, permease component
IS503_RS19750	COG1175	transmembrane transport
IS503_RS19755	COG2182	Extracellular solute-binding protein
IS503_RS19765	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS503_RS19780	COG2364	Membrane
IS503_RS19810	COG3695	enzyme binding
IS503_RS19815	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IS503_RS19820	COG1946	Acyl-CoA thioesterase
IS503_RS19825	COG0004	ammonium transporteR
IS503_RS19830	COG0347	Belongs to the P(II) protein family
IS503_RS19835	COG1132	(ABC) transporter
IS503_RS19840	COG1132	(ABC) transporter
IS503_RS19845	COG1522	sequence-specific DNA binding
IS503_RS19860	COG4533	DNA binding
IS503_RS19870	COG0824	Thioesterase
IS503_RS19875	COG1555	photosystem II stabilization
IS503_RS19880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS503_RS19885	COG0776	regulation of translation
IS503_RS19890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IS503_RS19910	COG0271	Belongs to the BolA IbaG family
IS503_RS19915	COG3056	Lipoprotein
IS503_RS19920	COG2223	nitrite transmembrane transporter activity
IS503_RS19925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS503_RS19930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS503_RS19935	COG1845	cytochrome c oxidase, subunit III
IS503_RS19940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IS503_RS19955	COG1414	Transcriptional regulator
IS503_RS19960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS503_RS19965	COG1053	succinate dehydrogenase
IS503_RS19975	COG1053	succinate dehydrogenase
IS503_RS19990	COG0673	inositol 2-dehydrogenase activity
IS503_RS19995	COG2814	Major facilitator Superfamily
IS503_RS20005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IS503_RS20010	COG0693	protein deglycase activity
IS503_RS20030	COG0142	geranyltranstransferase activity
IS503_RS20040	COG0667	Aldo Keto reductase
IS503_RS20045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IS503_RS20065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS503_RS20065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS503_RS20075	COG4238	major outer membrane lipoprotein
IS503_RS20095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS503_RS20100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS503_RS20105	COG1862	Preprotein translocase
IS503_RS20130	COG0450	alkyl hydroperoxide reductase
IS503_RS20140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS20155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS503_RS20165	COG1228	amidohydrolase
IS503_RS20175	COG1335	isochorismatase
IS503_RS20180	COG0583	DNA-binding transcription factor activity
IS503_RS20185	COG0366	Alpha amylase catalytic
IS503_RS20210	COG0420	3'-5' exonuclease activity
IS503_RS20215	COG0419	ATPase involved in DNA repair
IS503_RS20220	COG1940	carbohydrate kinase activity
IS503_RS20235	COG4126	flavin adenine dinucleotide binding
IS503_RS20245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS503_RS20250	COG3416	Protein conserved in bacteria
IS503_RS20260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IS503_RS20270	COG1785	Belongs to the alkaline phosphatase family
IS503_RS20310	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IS503_RS20315	COG1335	isochorismatase
IS503_RS20320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IS503_RS20325	COG0113	porphobilinogen synthase activity
IS503_RS20335	COG2175	clavaminate synthase activity
IS503_RS20340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS503_RS20345	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IS503_RS20350	COG4521	taurine ABC transporter
IS503_RS20355	COG2040	homocysteine
IS503_RS20360	COG0833	amino acid
IS503_RS20385	COG4303	Ethanolamine ammonia lyase large subunit
IS503_RS20390	COG4302	ethanolamine ammonia-lyase activity
IS503_RS20430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS20435	COG1126	abc transporter atp-binding protein
IS503_RS20440	COG4597	amino acid ABC transporter
IS503_RS20445	COG0765	amino acid transport
IS503_RS20460	COG3188	usher protein
IS503_RS20485	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IS503_RS20495	COG3639	organic phosphonate transmembrane transporter activity
IS503_RS20515	COG0791	NLP P60 protein
IS503_RS20565	COG2909	trisaccharide binding
IS503_RS20570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IS503_RS20575	COG0022	dehydrogenase e1 component
IS503_RS20580	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS503_RS20585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS503_RS20605	COG1070	Carbohydrate kinase
IS503_RS20610	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS20615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS503_RS20620	COG3775	system Galactitol-specific IIC component
IS503_RS20625	COG0625	glutathione transferase activity
IS503_RS20630	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IS503_RS20645	COG0579	oxidoreductase
IS503_RS20650	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS20655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS503_RS20660	COG1113	amino acid transport
IS503_RS20665	COG1802	Transcriptional regulator
IS503_RS20685	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS503_RS20690	COG0454	-acetyltransferase
IS503_RS20705	COG2991	Protein conserved in bacteria
IS503_RS20720	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS503_RS20725	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS503_RS20740	COG3034	peptidoglycan biosynthetic process
IS503_RS20745	COG0121	glutamine amidotransferase
IS503_RS20755	COG1960	acyl-CoA dehydrogenase activity
IS503_RS20760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS503_RS20770	COG0583	DNA-binding transcription factor activity
IS503_RS20780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS503_RS20790	COG2226	methyltransferase
IS503_RS20800	COG0741	lytic transglycosylase activity
IS503_RS20800	COG1388	LysM domain
IS503_RS20805	COG2226	methyltransferase
IS503_RS20815	COG2814	Major facilitator Superfamily
IS503_RS20820	COG0583	DNA-binding transcription factor activity
IS503_RS20825	COG0656	L-ascorbic acid biosynthetic process
IS503_RS20860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS503_RS20870	COG2011	ABC-type metal ion transport system permease component
IS503_RS20875	COG1464	Belongs to the NlpA lipoprotein family
IS503_RS20885	COG1720	tRNA m6t6A37 methyltransferase activity
IS503_RS20895	COG0791	NLP P60 protein
IS503_RS20900	COG3015	lipoprotein NlpE involved in copper resistance
IS503_RS20905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IS503_RS20920	COG4568	rho-dependent transcription termination
IS503_RS20930	COG0346	lactoylglutathione lyase activity
IS503_RS20935	COG1982	Orn Lys Arg decarboxylase major
IS503_RS20945	COG0587	DNA-directed DNA polymerase activity
IS503_RS20975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IS503_RS20985	COG0750	zinc metalloprotease
IS503_RS20990	COG0575	Belongs to the CDS family
IS503_RS21000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IS503_RS21025	COG0024	Methionine aminopeptidase
IS503_RS21030	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IS503_RS21045	COG3835	regulator
IS503_RS21050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS503_RS21070	COG2860	membrane
IS503_RS21090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS21095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS503_RS21100	COG1120	ATPase activity
IS503_RS21105	COG4774	siderophore transport
IS503_RS21110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS503_RS21210	COG1643	Atp-dependent helicase
IS503_RS21215	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IS503_RS21235	COG0617	tRNA 3'-terminal CCA addition
IS503_RS21240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS503_RS21260	COG0726	polysaccharide deacetylase
IS503_RS21265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS21270	COG0842	Transport permease protein
IS503_RS21275	COG1131	(ABC) transporter
IS503_RS21280	COG0288	reversible hydration of carbon dioxide
IS503_RS21295	COG4993	Dehydrogenase
IS503_RS21300	COG2132	Multicopper oxidase
IS503_RS21345	COG3064	Membrane
IS503_RS21360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS503_RS21365	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS503_RS21370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IS503_RS21375	COG2186	Transcriptional regulator
IS503_RS21380	COG1113	amino acid transport
IS503_RS21385	COG2211	Major facilitator Superfamily
IS503_RS21390	COG3940	Belongs to the glycosyl hydrolase 43 family
IS503_RS21395	COG3725	Membrane protein required for beta-lactamase induction
IS503_RS21400	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS503_RS21410	COG4969	Belongs to the N-Me-Phe pilin family
IS503_RS21415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS503_RS21420	COG1459	type II secretion system
IS503_RS21445	COG0494	nUDIX hydrolase
IS503_RS21465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IS503_RS21470	COG0849	cell division
IS503_RS21495	COG0772	Belongs to the SEDS family
IS503_RS21510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IS503_RS21515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IS503_RS21520	COG0768	penicillin binding
IS503_RS21540	COG1609	Transcriptional regulator
IS503_RS21595	COG0738	Major facilitator superfamily
IS503_RS21605	COG0583	DNA-binding transcription factor activity
IS503_RS21610	COG2271	Major facilitator Superfamily
IS503_RS21615	COG2814	Major facilitator Superfamily
IS503_RS21635	COG1178	ABC-type Fe3 transport system permease component
IS503_RS21645	COG0586	Pfam SNARE associated Golgi protein
IS503_RS21665	COG0235	Class ii aldolase
IS503_RS21670	COG0417	DNA replication proofreading
IS503_RS21680	COG0564	pseudouridine synthase activity
IS503_RS21690	COG3493	citrate carrier protein
IS503_RS21705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS503_RS21710	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IS503_RS21720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS503_RS21765	COG0505	Belongs to the CarA family
IS503_RS21775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IS503_RS21800	COG1047	Peptidyl-prolyl cis-trans
IS503_RS21815	COG0196	riboflavin kinase activity
IS503_RS21825	COG0583	DNA-binding transcription factor activity
IS503_RS21850	COG4735	regulation of single-species biofilm formation
IS503_RS21855	COG1584	GPR1 FUN34 yaaH family protein
IS503_RS21860	COG0477	Major facilitator Superfamily
IS503_RS21865	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS503_RS21870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS503_RS21875	COG1115	amino acid carrier protein
IS503_RS21890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IS503_RS21900	COG0527	aspartate kinase activity
IS503_RS21900	COG0460	homoserine dehydrogenase
IS503_RS21910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IS503_RS21920	COG0745	RESPONSE REGULATOR receiver
IS503_RS21925	COG4452	Inner membrane protein CreD
IS503_RS21930	COG2205	protein histidine kinase activity
IS503_RS21935	COG0745	RESPONSE REGULATOR receiver
IS503_RS21940	COG3045	CreA protein
IS503_RS21945	COG2207	Transcriptional regulator
IS503_RS21945	COG3708	Transcriptional regulator
IS503_RS21965	COG0741	lytic transglycosylase activity
IS503_RS21970	COG0488	(ABC) transporter
IS503_RS21980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IS503_RS21985	COG0560	Phosphoserine phosphatase
IS503_RS21990	COG3726	membrane protein affecting hemolysin expression
IS503_RS22020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS503_RS22025	COG0084	hydrolase, TatD family'
IS503_RS22030	COG4667	esterase of the alpha-beta hydrolase superfamily
IS503_RS22040	COG2823	Periplasmic or secreted lipoprotein
IS503_RS22050	COG1011	Hydrolase
IS503_RS22055	COG0456	acetyltransferase
IS503_RS22060	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IS503_RS22095	COG3706	GGDEF domain
IS503_RS22100	COG4114	ferric iron reductase
IS503_RS22105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS22105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS22110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS503_RS22115	COG2197	response regulator
IS503_RS22120	COG2197	response regulator
IS503_RS22135	COG2966	Psort location CytoplasmicMembrane, score
IS503_RS22150	COG1484	DNA-dependent DNA replication
IS503_RS22165	COG5464	transposase or invertase
IS503_RS22175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS503_RS22180	COG3716	PTS system mannose fructose sorbose family IID component
IS503_RS22185	COG3715	PTS system
IS503_RS22200	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS503_RS22200	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS503_RS22205	COG0456	acetyltransferase
IS503_RS22205	COG1214	PFAM Peptidase M22, glycoprotease
IS503_RS22215	COG1737	Transcriptional regulator
IS503_RS22220	COG0800	Aldolase
IS503_RS22225	COG3734	2-keto-3-deoxy-galactonokinase
IS503_RS22240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IS503_RS22270	COG1846	Transcriptional regulator
IS503_RS22280	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS503_RS22290	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS22295	COG3384	dioxygenase
IS503_RS22305	COG3971	2-oxopent-4-enoate hydratase activity
IS503_RS22325	COG2368	4-hydroxyphenylacetate
IS503_RS22330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS503_RS22345	COG1966	Carbon starvation protein
IS503_RS22350	COG2879	small protein
IS503_RS22355	COG0523	cobalamin synthesis protein
IS503_RS22365	COG1012	belongs to the aldehyde dehydrogenase family
IS503_RS22370	COG5464	transposase or invertase
IS503_RS22375	COG1917	Cupin 2, conserved barrel domain protein
IS503_RS22375	COG2207	Transcriptional regulator
IS503_RS22385	COG2733	membrane
IS503_RS22400	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IS503_RS22405	COG1924	4 iron, 4 sulfur cluster binding
IS503_RS22420	COG1566	PFAM secretion protein HlyD family protein
IS503_RS22430	COG5457	Domain of unknown function (DUF1127)
IS503_RS22435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS503_RS22445	COG0583	DNA-binding transcription factor activity
IS503_RS22450	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS503_RS22460	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS22465	COG1129	ABC transporter
IS503_RS22470	COG1879	ABC-type sugar transport system periplasmic component
IS503_RS22480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS22485	COG1129	ABC transporter
IS503_RS22485	COG0842	Transport permease protein
IS503_RS22490	COG0842	Transport permease protein
IS503_RS22520	COG2850	peptidyl-arginine hydroxylation
IS503_RS22535	COG5002	protein histidine kinase activity
IS503_RS22540	COG0745	RESPONSE REGULATOR receiver
IS503_RS22545	COG1538	Outer membrane efflux protein
IS503_RS22550	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS22555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS22560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS503_RS22570	COG3040	lipid binding
IS503_RS22575	COG0789	Transcriptional regulator
IS503_RS22580	COG3631	Ketosteroid isomerase-related protein
IS503_RS22585	COG0300	oxidoreductase activity
IS503_RS22600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS503_RS22620	COG3272	Protein of unknown function (DUF1722)
IS503_RS22630	COG4580	involved in the transport of maltose and maltodextrins
IS503_RS22635	COG2115	Belongs to the xylose isomerase family
IS503_RS22640	COG2211	Major facilitator Superfamily
IS503_RS22645	COG3507	Belongs to the glycosyl hydrolase 43 family
IS503_RS22665	COG1216	Glycosyl transferase, family 2
IS503_RS22770	COG0071	Belongs to the small heat shock protein (HSP20) family
IS503_RS22880	COG3423	Transcriptional regulator
IS503_RS22895	COG3732	PTS system glucitol sorbitol-specific
IS503_RS22900	COG0673	inositol 2-dehydrogenase activity
IS503_RS22920	COG3121	Chaperone
IS503_RS22930	COG0582	viral genome integration into host DNA
IS503_RS23015	COG0582	viral genome integration into host DNA
IS503_RS23025	COG0288	reversible hydration of carbon dioxide
IS503_RS23030	COG0659	secondary active sulfate transmembrane transporter activity
IS503_RS23035	COG1064	alcohol dehydrogenase
IS503_RS23040	COG1175	transmembrane transport
IS503_RS23045	COG0395	ABC-type sugar transport system, permease component
IS503_RS23050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS503_RS23055	COG3842	ATPase activity
IS503_RS23070	COG1082	Xylose isomerase domain protein TIM barrel
IS503_RS23080	COG3962	Belongs to the TPP enzyme family
IS503_RS23085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS503_RS23090	COG1737	Transcriptional regulator
IS503_RS23090	COG0837	glucose binding
IS503_RS23095	COG3718	enzyme involved in inositol metabolism
IS503_RS23110	COG0433	COG0433 Predicted ATPase
IS503_RS23115	COG0795	lipopolysaccharide-transporting ATPase activity
IS503_RS23120	COG0795	lipopolysaccharide-transporting ATPase activity
IS503_RS23130	COG2927	DNA polymerase III (CHI subunit)
IS503_RS23135	COG0525	valine-tRNA ligase activity
IS503_RS23160	COG2731	YhcH YjgK YiaL family protein
IS503_RS23195	COG1263	PTS System
IS503_RS23195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS503_RS23200	COG0366	Alpha amylase catalytic
IS503_RS23205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS503_RS23210	COG1486	melibiose metabolic process
IS503_RS23235	COG0602	queuosine metabolic process
IS503_RS23240	COG2026	Addiction module toxin, RelE StbE family
IS503_RS23245	COG3077	Addiction module antitoxin, RelB DinJ family
IS503_RS23250	COG3711	transcriptional antiterminator
IS503_RS23250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS503_RS23255	COG2706	6-phosphogluconolactonase activity
IS503_RS23270	COG3964	amidohydrolase
IS503_RS23310	COG0312	modulator of DNA gyrase
IS503_RS23340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS503_RS23350	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS23355	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS23360	COG1129	ABC transporter
IS503_RS23365	COG1879	ABC-type sugar transport system periplasmic component
IS503_RS23380	COG2105	PFAM AIG2 family protein
IS503_RS23385	COG2911	Protein conserved in bacteria
IS503_RS23390	COG0729	surface antigen
IS503_RS23400	COG1253	flavin adenine dinucleotide binding
IS503_RS23415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IS503_RS23430	COG1733	regulation of RNA biosynthetic process
IS503_RS23435	COG0702	epimerase
IS503_RS23445	COG0697	spore germination
IS503_RS23455	COG1113	amino acid transport
IS503_RS23460	COG0545	Peptidyl-prolyl cis-trans isomerase
IS503_RS23465	COG3061	Opacity-associated protein A
IS503_RS23475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IS503_RS23480	COG2965	DNA replication, synthesis of RNA primer
IS503_RS23540	COG1073	alpha beta
IS503_RS23545	COG3650	response to hydrogen peroxide
IS503_RS23555	COG1960	acyl-CoA dehydrogenase activity
IS503_RS23560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS503_RS23565	COG0557	exoribonuclease II activity
IS503_RS23580	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IS503_RS23590	COG0330	HflC and HflK could
IS503_RS23595	COG0330	HflC and HflK could
IS503_RS23600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS503_RS23620	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS503_RS23625	COG0802	atpase or kinase
IS503_RS23630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IS503_RS23630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IS503_RS23635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS503_RS23655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS503_RS23675	COG3264	Mechanosensitive ion channel
IS503_RS23675	COG1511	domain protein
IS503_RS23690	COG1053	succinate dehydrogenase
IS503_RS23695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS503_RS23715	COG2076	Multidrug Resistance protein
IS503_RS23720	COG5510	response to toxic substance
IS503_RS23735	COG1509	lysine 2,3-aminomutase activity
IS503_RS23800	COG0531	amino acid
IS503_RS23805	COG3030	protein affecting phage T7 exclusion by the F plasmid
IS503_RS23810	COG1027	Aspartate ammonia-lyase
IS503_RS23815	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS503_RS23830	COG1309	transcriptional regulator
IS503_RS23860	COG0457	Tetratricopeptide repeat
IS503_RS23865	COG0726	polysaccharide deacetylase
IS503_RS23865	COG1649	PFAM Uncharacterised BCR, COG1649
IS503_RS23870	COG1215	transferase activity, transferring glycosyl groups
IS503_RS23885	COG0861	Integral membrane protein TerC family
IS503_RS23925	COG1486	melibiose metabolic process
IS503_RS23930	COG2169	Transcriptional regulator
IS503_RS23940	COG2824	Alkylphosphonate utilization operon protein PhnA
IS503_RS23945	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IS503_RS23950	COG2188	Transcriptional regulator
IS503_RS23955	COG3624	Phosphonate C-P lyase system protein PhnG
IS503_RS23960	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IS503_RS23965	COG3626	phosphonate metabolism
IS503_RS23970	COG3627	carbon phosphorus lyase activity
IS503_RS23975	COG4107	phosphonate C-P lyase system protein PhnK
IS503_RS23980	COG4778	phosphonate C-P lyase system protein PhnL
IS503_RS23985	COG3454	Phosphonate metabolism
IS503_RS23995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IS503_RS24005	COG4191	Histidine kinase
IS503_RS24005	COG0784	Response regulator, receiver
IS503_RS24010	COG1129	ABC transporter
IS503_RS24015	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS24040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IS503_RS24045	COG1301	dicarboxylic acid transport
IS503_RS24055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS503_RS24060	COG3162	membrane
IS503_RS24090	COG3539	Fimbrial protein
IS503_RS24095	COG1346	cytolysis
IS503_RS24100	COG1380	Effector of murein hydrolase LrgA
IS503_RS24105	COG0583	DNA-binding transcription factor activity
IS503_RS24110	COG0025	NhaP-type Na H and K H
IS503_RS24115	COG2252	PERMEase
IS503_RS24120	COG0625	glutathione transferase activity
IS503_RS24125	COG0789	Transcriptional regulator
IS503_RS24135	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS503_RS24165	COG1234	tRNA 3'-trailer cleavage
IS503_RS24170	COG1609	Transcriptional regulator
IS503_RS24175	COG0483	inositol monophosphate 1-phosphatase activity
IS503_RS24185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS503_RS24205	COG4771	TonB-dependent receptor
IS503_RS24210	COG0741	lytic transglycosylase activity
IS503_RS24225	COG2315	Protein conserved in bacteria
IS503_RS24230	COG0432	Pfam Uncharacterised protein family UPF0047
IS503_RS24245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IS503_RS24250	COG0305	Participates in initiation and elongation during chromosome replication
IS503_RS24265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS503_RS24275	COG0735	belongs to the Fur family
IS503_RS24280	COG3237	CsbD-like
IS503_RS24290	COG0534	Mate efflux family protein
IS503_RS24300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IS503_RS24370	COG0251	oxidation-reduction process
IS503_RS24380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IS503_RS24390	COG0527	aspartate kinase activity
IS503_RS24440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IS503_RS24450	COG0456	acetyltransferase
IS503_RS24480	COG0151	Belongs to the GarS family
IS503_RS24490	COG4191	Histidine kinase
IS503_RS24495	COG3678	ATP-independent chaperone mediated protein folding
IS503_RS24530	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IS503_RS24545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS503_RS24550	COG2104	thiamine diphosphate biosynthetic process
IS503_RS24565	COG3706	GGDEF domain
IS503_RS24575	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS503_RS24580	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS503_RS24615	COG0250	Participates in transcription elongation, termination and antitermination
IS503_RS24690	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IS503_RS24700	COG1739	Uncharacterized protein family UPF0029
IS503_RS24740	COG0805	protein transport
IS503_RS24760	COG3165	ubiquinone biosynthetic process from chorismate
IS503_RS24790	COG0583	DNA-binding transcription factor activity
IS503_RS24795	COG0697	spore germination
IS503_RS24800	COG0561	phosphatase activity
IS503_RS24805	COG2267	carboxylic ester hydrolase activity
IS503_RS24810	COG1280	lysine exporter protein (LysE YggA)
IS503_RS24820	COG1280	lysine exporter protein (LysE YggA)
IS503_RS24850	COG0210	DNA helicase
IS503_RS24855	COG1011	Hydrolase
IS503_RS24885	COG3072	Adenylate cyclase
IS503_RS24900	COG2959	enzyme of heme biosynthesis
IS503_RS24905	COG3071	HemY protein
IS503_RS24950	COG2244	polysaccharide biosynthetic process
IS503_RS24955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IS503_RS24960	COG0456	acetyltransferase
IS503_RS24965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IS503_RS24970	COG1088	dTDP-glucose 4,6-dehydratase activity
IS503_RS24975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IS503_RS24980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IS503_RS24990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS503_RS24995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IS503_RS25000	COG3118	belongs to the thioredoxin family
IS503_RS25025	COG1811	Na channel or pump
IS503_RS25035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS503_RS25040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS503_RS25050	COG0583	DNA-binding transcription factor activity
IS503_RS25055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS503_RS25070	COG3978	acetolactate synthase activity
IS503_RS25090	COG3085	chromosome segregation
IS503_RS25165	COG0583	DNA-binding transcription factor activity
IS503_RS25180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IS503_RS25195	COG3443	Belongs to the bacterial solute-binding protein 9 family
IS503_RS25200	COG2207	Transcriptional regulator
IS503_RS25210	COG0371	Dehydrogenase
IS503_RS25215	COG0697	spore germination
IS503_RS25225	COG0583	DNA-binding transcription factor activity
IS503_RS25235	COG0737	Belongs to the 5'-nucleotidase family
IS503_RS25245	COG0460	homoserine dehydrogenase
IS503_RS25245	COG0527	aspartate kinase activity
IS503_RS25250	COG0626	cystathionine gamma-synthase activity
IS503_RS25265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IS503_RS25270	COG1609	Transcriptional regulator
IS503_RS25275	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS503_RS25290	COG1575	Belongs to the MenA family. Type 1 subfamily
IS503_RS25310	COG3678	ATP-independent chaperone mediated protein folding
IS503_RS25315	COG0745	RESPONSE REGULATOR receiver
IS503_RS25320	COG2205	protein histidine kinase activity
IS503_RS25325	COG2258	MOSC domain
IS503_RS25330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IS503_RS25370	COG1129	ABC transporter
IS503_RS25375	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS25380	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS25385	COG1454	alcohol dehydrogenase
IS503_RS25395	COG2211	Major facilitator Superfamily
IS503_RS25455	COG0205	6-phosphofructokinase activity
IS503_RS25475	COG0437	4 iron, 4 sulfur cluster binding
IS503_RS25480	COG2864	formate dehydrogenase
IS503_RS25495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IS503_RS25505	COG0456	acetyltransferase
IS503_RS25520	COG1011	Hydrolase
IS503_RS25535	COG3852	Histidine kinase
IS503_RS25550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS503_RS25570	COG0204	Acyl-transferase
IS503_RS25580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IS503_RS25585	COG3084	Protein conserved in bacteria
IS503_RS25595	COG1763	Mo-molybdopterin cofactor biosynthetic process
IS503_RS25620	COG2186	Transcriptional regulator
IS503_RS25625	COG0477	Major facilitator Superfamily
IS503_RS25630	COG1609	Transcriptional regulator
IS503_RS25635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS503_RS25645	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS503_RS25650	COG1129	ABC transporter
IS503_RS25680	COG1522	sequence-specific DNA binding
IS503_RS25685	COG0716	FMN binding
IS503_RS25700	COG3312	ion transport
IS503_RS25755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS503_RS25760	COG0573	inorganic phosphate transmembrane transporter activity
IS503_RS25765	COG0581	inorganic phosphate transmembrane transporter activity
IS503_RS25770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS503_RS25775	COG0704	Plays a role in the regulation of phosphate uptake
IS503_RS25785	COG2382	esterase
IS503_RS25790	COG0363	glucosamine-6-phosphate deaminase activity
IS503_RS25795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS503_RS25800	COG2252	PERMEase
IS503_RS25805	COG0431	NADPH-dependent FMN reductase
IS503_RS25810	COG2091	lysine biosynthetic process via aminoadipic acid
IS503_RS25840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IS503_RS25955	COG3436	PFAM IS66 Orf2 family protein
IS503_RS25960	COG4372	Transposase
IS503_RS26045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS503_RS26070	COG2144	transferase activity, transferring acyl groups
IS503_RS26105	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
IS503_RS26125	COG4245	von Willebrand factor, type A
IS503_RS26130	COG4245	von Willebrand factor, type A
IS503_RS26140	COG4245	von Willebrand factor, type A
IS503_RS26160	COG1358	cellular component organization or biogenesis
IS503_RS26250	COG3321	synthase
IS503_RS26250	COG1028	Short-chain dehydrogenase reductase Sdr
IS503_RS26250	COG0604	alcohol dehydrogenase
IS503_RS26265	COG1522	sequence-specific DNA binding
IS503_RS26435	COG0523	cobalamin synthesis protein
IS503_RS26460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS503_RS26470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IS503_RS26505	COG0500	methyltransferase
IS503_RS26540	COG2382	esterase
IS503_RS26560	COG1475	DNA binding
IS503_RS26565	COG3969	phosphoadenosine phosphosulfate
IS503_RS26580	COG1595	DNA-templated transcription, initiation
IS503_RS26590	COG4772	TonB-dependent receptor
IS503_RS26595	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IS503_RS26610	COG5642	Protein of unknown function (DUF2384)
IS503_RS26615	COG5654	RES domain protein
IS503_RS26635	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS503_RS26640	COG0656	L-ascorbic acid biosynthetic process
IS503_RS26665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS503_RS26710	COG0735	belongs to the Fur family
IS503_RS26715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IS503_RS26720	COG0523	cobalamin synthesis protein
IS503_RS26785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IS503_RS26870	COG4680	protein conserved in bacteria
IS503_RS26875	COG5499	transcription regulator containing HTH domain
IS503_RS26930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IS503_RS26945	COG0789	Transcriptional regulator
IS503_RS26950	COG2205	protein histidine kinase activity
IS503_RS26955	COG0745	RESPONSE REGULATOR receiver
IS503_RS26960	COG1276	copper resistance
IS503_RS26965	COG2372	response to copper ion
IS503_RS26970	COG3667	copper resistance
IS503_RS26975	COG2132	Multicopper oxidase
IS503_RS26985	COG0739	heme binding
IS503_RS27015	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS503_RS27185	COG5499	transcription regulator containing HTH domain
IS503_RS27255	COG1475	DNA binding
IS503_RS27365	COG1192	Involved in chromosome partitioning
IS503_RS27480	COG5001	Diguanylate cyclase
IS503_RS27480	COG3300	MHYT domain
IS503_RS27630	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities