locus-tag	class	description
IS495_RS00020	COG0187	DNA topoisomerase II activity
IS495_RS00025	COG0561	phosphatase activity
IS495_RS00040	COG2186	Transcriptional regulator
IS495_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
IS495_RS00050	COG0800	Aldolase
IS495_RS00070	COG2271	Major facilitator Superfamily
IS495_RS00075	COG0823	Involved in the tonB-independent uptake of proteins
IS495_RS00080	COG5645	(Lipo)protein
IS495_RS00095	COG3645	SOS response
IS495_RS00105	COG2188	Transcriptional regulator
IS495_RS00120	COG2149	membrane
IS495_RS00140	COG2610	gluconate transmembrane transporter activity
IS495_RS00150	COG0583	DNA-binding transcription factor activity
IS495_RS00155	COG2814	Major facilitator Superfamily
IS495_RS00185	COG0028	Belongs to the TPP enzyme family
IS495_RS00190	COG0440	acetolactate synthase activity
IS495_RS00195	COG2197	response regulator
IS495_RS00205	COG2271	Major facilitator Superfamily
IS495_RS00245	COG2188	Transcriptional regulator
IS495_RS00270	COG4580	involved in the transport of maltose and maltodextrins
IS495_RS00275	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS495_RS00280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS00280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS00290	COG1609	Transcriptional regulator
IS495_RS00300	COG3384	dioxygenase
IS495_RS00305	COG0583	DNA-binding transcription factor activity
IS495_RS00310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IS495_RS00315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS495_RS00320	COG2828	Protein conserved in bacteria
IS495_RS00335	COG0697	spore germination
IS495_RS00340	COG1263	PTS System
IS495_RS00340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS00350	COG2814	Major facilitator Superfamily
IS495_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS495_RS00395	COG0583	DNA-binding transcription factor activity
IS495_RS00420	COG1464	Belongs to the NlpA lipoprotein family
IS495_RS00435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IS495_RS00445	COG1064	alcohol dehydrogenase
IS495_RS00475	COG2211	Major facilitator Superfamily
IS495_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
IS495_RS00490	COG1486	melibiose metabolic process
IS495_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS00495	COG1263	PTS System
IS495_RS00500	COG2982	Protein involved in outer membrane biogenesis
IS495_RS00505	COG2233	PERMEase
IS495_RS00510	COG0786	glutamate:sodium symporter activity
IS495_RS00530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IS495_RS00555	COG3152	Membrane
IS495_RS00565	COG1494	fructose-1,6-bisphosphatase
IS495_RS00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IS495_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS495_RS00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS495_RS00600	COG2860	membrane
IS495_RS00610	COG2169	Transcriptional regulator
IS495_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS495_RS00615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IS495_RS00620	COG1561	YicC-like family, N-terminal region
IS495_RS00625	COG3039	Transposase
IS495_RS00645	COG1131	(ABC) transporter
IS495_RS00650	COG0842	Transport permease protein
IS495_RS00675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IS495_RS00710	COG1519	Transferase
IS495_RS00715	COG1216	Glycosyl transferase, family 2
IS495_RS00720	COG0438	transferase activity, transferring glycosyl groups
IS495_RS00730	COG0859	PFAM glycosyl transferase family 9
IS495_RS00755	COG0859	PFAM glycosyl transferase family 9
IS495_RS00770	COG0156	8-amino-7-oxononanoate synthase activity
IS495_RS00780	COG0463	Glycosyl transferase, family 2
IS495_RS00785	COG2861	carbohydrate metabolic process
IS495_RS00790	COG4942	peptidase
IS495_RS00800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS495_RS00805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS495_RS00825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IS495_RS00835	COG2186	Transcriptional regulator
IS495_RS00855	COG3722	fumarate hydratase activity
IS495_RS00875	COG1566	PFAM secretion protein HlyD family protein
IS495_RS00880	COG0625	glutathione transferase activity
IS495_RS00890	COG3276	selenocysteine insertion sequence binding
IS495_RS00895	COG1414	Transcriptional regulator
IS495_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS495_RS00905	COG3977	Valine--pyruvate aminotransferase
IS495_RS00910	COG0366	Alpha amylase catalytic
IS495_RS00915	COG2992	FlgJ-related protein
IS495_RS00920	COG1609	Transcriptional regulator
IS495_RS00920	COG2207	Transcriptional regulator
IS495_RS00925	COG4214	carbohydrate transport
IS495_RS00935	COG4213	ABC transporter substrate-binding protein
IS495_RS00950	COG4682	membrane
IS495_RS00955	COG4682	membrane
IS495_RS00960	COG3274	enterobacterial common antigen metabolic process
IS495_RS00995	COG1278	Cold shock
IS495_RS01000	COG2944	sequence-specific DNA binding
IS495_RS01005	COG2814	Major facilitator Superfamily
IS495_RS01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS01035	COG1609	Transcriptional regulator
IS495_RS01040	COG2885	chlorophyll binding
IS495_RS01045	COG0243	molybdopterin cofactor binding
IS495_RS01050	COG0456	acetyltransferase
IS495_RS01055	COG2818	Glycosylase
IS495_RS01060	COG5571	outer membrane autotransporter
IS495_RS01065	COG2223	nitrite transmembrane transporter activity
IS495_RS01095	COG0747	negative chemotaxis
IS495_RS01100	COG0601	transmembrane transport
IS495_RS01105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS495_RS01110	COG0444	Belongs to the ABC transporter superfamily
IS495_RS01115	COG4608	Belongs to the ABC transporter superfamily
IS495_RS01140	COG1215	transferase activity, transferring glycosyl groups
IS495_RS01145	COG0457	Tetratricopeptide repeat
IS495_RS01160	COG2194	sulfuric ester hydrolase activity
IS495_RS01190	COG1215	transferase activity, transferring glycosyl groups
IS495_RS01195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IS495_RS01200	COG0457	Tetratricopeptide repeat
IS495_RS01200	COG3118	belongs to the thioredoxin family
IS495_RS01205	COG2199	diguanylate cyclase activity
IS495_RS01205	COG2200	EAL domain
IS495_RS01215	COG0612	Peptidase, M16
IS495_RS01225	COG2982	Protein involved in outer membrane biogenesis
IS495_RS01230	COG0477	Major facilitator Superfamily
IS495_RS01235	COG1295	ribonuclease BN
IS495_RS01240	COG0583	DNA-binding transcription factor activity
IS495_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS01250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS495_RS01260	COG1454	alcohol dehydrogenase
IS495_RS01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS495_RS01275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IS495_RS01280	COG0671	phosphoesterase, PA-phosphatase related
IS495_RS01300	COG0589	response to stress
IS495_RS01310	COG0306	phosphate transporter
IS495_RS01315	COG2081	HI0933 family
IS495_RS01320	COG2239	Acts as a magnesium transporter
IS495_RS01330	COG1124	(ABC) transporter
IS495_RS01340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS495_RS01345	COG0601	transmembrane transport
IS495_RS01350	COG0747	negative chemotaxis
IS495_RS01360	COG3479	Phenolic acid decarboxylase
IS495_RS01400	COG0628	permease
IS495_RS01405	COG0477	Major facilitator Superfamily
IS495_RS01415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS495_RS01430	COG3714	YhhN family
IS495_RS01440	COG3776	membrane
IS495_RS01445	COG0742	ribosomal rna small subunit methyltransferase
IS495_RS01450	COG0552	protein localization to endoplasmic reticulum
IS495_RS01455	COG2884	Cell division ATP-binding protein ftsE
IS495_RS01460	COG2177	Part of the ABC transporter FtsEX involved in
IS495_RS01475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS495_RS01485	COG0683	leucine binding
IS495_RS01495	COG0683	leucine binding
IS495_RS01500	COG0559	Belongs to the binding-protein-dependent transport system permease family
IS495_RS01550	COG0584	glycerophosphoryl diester phosphodiesterase
IS495_RS01560	COG0405	Gamma-glutamyltransferase
IS495_RS01565	COG1247	-acetyltransferase
IS495_RS01575	COG0673	inositol 2-dehydrogenase activity
IS495_RS01580	COG1741	Belongs to the pirin family
IS495_RS01585	COG1609	Transcriptional regulator
IS495_RS01590	COG3265	gluconokinase activity
IS495_RS01595	COG2610	gluconate transmembrane transporter activity
IS495_RS01605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS495_RS01630	COG0058	SHG alpha-glucan phosphorylase activity
IS495_RS01645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS495_RS01660	COG1349	DNA-binding transcription factor activity
IS495_RS01670	COG0058	SHG alpha-glucan phosphorylase activity
IS495_RS01675	COG1640	4-alpha-glucanotransferase
IS495_RS01680	COG2610	gluconate transmembrane transporter activity
IS495_RS01690	COG1040	competence protein
IS495_RS01715	COG1918	ferrous iron import across plasma membrane
IS495_RS01720	COG2183	response to ionizing radiation
IS495_RS01725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS495_RS01750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IS495_RS01755	COG1011	Hydrolase
IS495_RS01765	COG0494	nUDIX hydrolase
IS495_RS01770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IS495_RS01795	COG4796	Type ii and iii secretion system protein
IS495_RS01810	COG3266	domain, Protein
IS495_RS01815	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IS495_RS01820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS495_RS01845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS495_RS01850	COG0402	S-adenosylhomocysteine deaminase activity
IS495_RS01855	COG0738	Major facilitator superfamily
IS495_RS01880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS495_RS01885	COG1289	transmembrane transporter activity
IS495_RS01895	COG1765	OsmC-like protein
IS495_RS01900	COG3954	Phosphoribulokinase
IS495_RS01910	COG0429	hydrolase of the alpha beta-hydrolase fold
IS495_RS01915	COG0488	(ABC) transporter
IS495_RS01930	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IS495_RS01935	COG1047	Peptidyl-prolyl cis-trans
IS495_RS01945	COG0545	Peptidyl-prolyl cis-trans isomerase
IS495_RS01950	COG2964	Protein conserved in bacteria
IS495_RS02005	COG0051	transcription antitermination factor activity, RNA binding
IS495_RS02030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IS495_RS02045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IS495_RS02110	COG0201	protein transport
IS495_RS02135	COG0202	RNA polymerase activity
IS495_RS02150	COG0789	Transcriptional regulator
IS495_RS02155	COG3036	rescue of stalled ribosome
IS495_RS02185	COG0758	DNA mediated transformation
IS495_RS02195	COG0551	DNA topoisomerase type I activity
IS495_RS02215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS495_RS02250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS495_RS02255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS02260	COG1309	transcriptional regulator
IS495_RS02265	COG0582	viral genome integration into host DNA
IS495_RS02280	COG3561	AntA/AntB antirepressor
IS495_RS02365	COG1802	Transcriptional regulator
IS495_RS02365	COG4626	Terminase
IS495_RS02390	COG4145	pantothenate transmembrane transporter activity
IS495_RS02395	COG3924	membrane
IS495_RS02400	COG0439	Biotin carboxylase
IS495_RS02405	COG0511	ligase activity, forming carbon-carbon bonds
IS495_RS02430	COG2199	diguanylate cyclase activity
IS495_RS02430	COG2200	EAL domain
IS495_RS02435	COG1077	Cell shape determining protein MreB Mrl
IS495_RS02440	COG1792	Involved in formation and maintenance of cell shape
IS495_RS02445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IS495_RS02455	COG1530	ribonuclease E activity
IS495_RS02460	COG3164	Protein of unknown function
IS495_RS02465	COG0312	modulator of DNA gyrase
IS495_RS02470	COG0583	DNA-binding transcription factor activity
IS495_RS02485	COG1289	transmembrane transporter activity
IS495_RS02490	COG2732	(Barnase) inhibitor
IS495_RS02515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS495_RS02520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS495_RS02525	COG3105	Protein conserved in bacteria
IS495_RS02530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS495_RS02550	COG0625	glutathione transferase activity
IS495_RS02555	COG2969	positive regulation of protein catabolic process
IS495_RS02565	COG0493	'glutamate synthase
IS495_RS02570	COG0070	glutamate synthase
IS495_RS02570	COG0069	glutamate synthase activity
IS495_RS02570	COG0067	glutamate synthase
IS495_RS02575	COG1242	4 iron, 4 sulfur cluster binding
IS495_RS02580	COG2271	Major facilitator Superfamily
IS495_RS02585	COG1063	alcohol dehydrogenase
IS495_RS02590	COG1312	Catalyzes the dehydration of D-mannonate
IS495_RS02595	COG0784	Response regulator, receiver
IS495_RS02595	COG2198	Histidine kinase
IS495_RS02595	COG5002	protein histidine kinase activity
IS495_RS02600	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IS495_RS02605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS495_RS02610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS02620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS02625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS495_RS02630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IS495_RS02635	COG1137	ATPase activity
IS495_RS02640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IS495_RS02645	COG3117	lipopolysaccharide transmembrane transporter activity
IS495_RS02650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IS495_RS02660	COG0530	calcium, potassium:sodium antiporter activity
IS495_RS02665	COG1127	ABC transporter
IS495_RS02670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS495_RS02675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS495_RS02680	COG2854	intermembrane phospholipid transfer
IS495_RS02685	COG3113	response to antibiotic
IS495_RS02690	COG5007	Belongs to the BolA IbaG family
IS495_RS02700	COG3423	Transcriptional regulator
IS495_RS02705	COG0142	geranyltranstransferase activity
IS495_RS02720	COG0697	spore germination
IS495_RS02730	COG2027	D-alanyl-D-alanine carboxypeptidase
IS495_RS02740	COG1534	Rna-binding protein
IS495_RS02750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IS495_RS02755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IS495_RS02765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IS495_RS02805	COG0195	Participates in both transcription termination and antitermination
IS495_RS02850	COG0814	amino acid
IS495_RS02855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS495_RS02860	COG0826	peptidase U32
IS495_RS02865	COG0826	peptidase U32
IS495_RS02870	COG3154	lipid carrier protein
IS495_RS02875	COG3153	acetyltransferase
IS495_RS02890	COG0693	protein deglycase activity
IS495_RS02895	COG0702	epimerase
IS495_RS02900	COG0701	Predicted permease
IS495_RS02905	COG2823	Periplasmic or secreted lipoprotein
IS495_RS02925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IS495_RS02940	COG1063	alcohol dehydrogenase
IS495_RS02945	COG3775	system Galactitol-specific IIC component
IS495_RS02950	COG3414	Phosphotransferase system galactitol-specific IIB component
IS495_RS02955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS02965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS02970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS495_RS02970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS02970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS495_RS02975	COG1105	Belongs to the carbohydrate kinase PfkB family
IS495_RS02985	COG1349	DNA-binding transcription factor activity
IS495_RS02990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS02995	COG2721	sulfolactate sulfo-lyase activity
IS495_RS03000	COG2271	Major facilitator Superfamily
IS495_RS03010	COG2084	Dehydrogenase
IS495_RS03015	COG1929	Belongs to the glycerate kinase type-1 family
IS495_RS03040	COG1741	Belongs to the pirin family
IS495_RS03045	COG0583	DNA-binding transcription factor activity
IS495_RS03050	COG3152	Membrane
IS495_RS03055	COG0435	Glutathione S-transferase
IS495_RS03060	COG2259	Doxx family
IS495_RS03070	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IS495_RS03075	COG4575	ribosome binding
IS495_RS03080	COG1422	Protein of unknown function (DUF1090)
IS495_RS03090	COG0586	Pfam SNARE associated Golgi protein
IS495_RS03095	COG2186	Transcriptional regulator
IS495_RS03100	COG2271	Major facilitator Superfamily
IS495_RS03110	COG2721	sulfolactate sulfo-lyase activity
IS495_RS03125	COG0861	Integral membrane protein TerC family
IS495_RS03130	COG0673	inositol 2-dehydrogenase activity
IS495_RS03135	COG1451	nucleotide metabolic process
IS495_RS03155	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS495_RS03155	COG1902	pentaerythritol trinitrate reductase activity
IS495_RS03205	COG1695	Transcriptional regulator
IS495_RS03210	COG2375	cellular response to nickel ion
IS495_RS03225	COG1461	Dihydroxyacetone kinase
IS495_RS03230	COG2376	Dihydroxyacetone kinase
IS495_RS03300	COG3247	response to pH
IS495_RS03310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS03310	COG0784	Response regulator, receiver
IS495_RS03310	COG2205	protein histidine kinase activity
IS495_RS03310	COG2198	Histidine kinase
IS495_RS03315	COG2197	response regulator
IS495_RS03340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS495_RS03345	COG0358	DNA primase activity
IS495_RS03350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IS495_RS03420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS495_RS03435	COG4991	sh3 domain protein
IS495_RS03440	COG3025	triphosphatase activity
IS495_RS03465	COG2960	long-chain fatty acid transporting porin activity
IS495_RS03480	COG3384	dioxygenase
IS495_RS03485	COG0754	glutathionylspermidine amidase activity
IS495_RS03500	COG0494	nUDIX hydrolase
IS495_RS03505	COG3151	Protein conserved in bacteria
IS495_RS03510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS495_RS03515	COG3150	esterase
IS495_RS03525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IS495_RS03530	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS495_RS03535	COG0642	Histidine kinase
IS495_RS03545	COG3111	PFAM Bacterial OB fold (BOF) protein
IS495_RS03550	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IS495_RS03555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IS495_RS03560	COG0204	Acyl-transferase
IS495_RS03565	COG2132	Multicopper oxidase
IS495_RS03570	COG1032	radical SAM domain protein
IS495_RS03580	COG0656	L-ascorbic acid biosynthetic process
IS495_RS03585	COG1979	alcohol dehydrogenase
IS495_RS03590	COG2207	Transcriptional regulator
IS495_RS03595	COG0586	Pfam SNARE associated Golgi protein
IS495_RS03600	COG0626	cystathionine gamma-synthase activity
IS495_RS03610	COG0848	biopolymer transport protein
IS495_RS03615	COG2211	Major facilitator Superfamily
IS495_RS03640	COG0625	glutathione transferase activity
IS495_RS03655	COG0754	glutathionylspermidine amidase activity
IS495_RS03660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS495_RS03680	COG0583	DNA-binding transcription factor activity
IS495_RS03685	COG0626	cystathionine gamma-synthase activity
IS495_RS03895	COG3039	Transposase
IS495_RS03945	COG3423	Transcriptional regulator
IS495_RS03955	COG1278	Cold shock
IS495_RS03960	COG3423	Transcriptional regulator
IS495_RS04025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS495_RS04035	COG1811	Na channel or pump
IS495_RS04040	COG1982	Orn Lys Arg decarboxylase major
IS495_RS04045	COG2211	Major facilitator Superfamily
IS495_RS04060	COG1194	a g-specific adenine glycosylase
IS495_RS04070	COG3171	Protein conserved in bacteria
IS495_RS04080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS495_RS04095	COG0762	integral membrane protein
IS495_RS04100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IS495_RS04105	COG2805	Type II/IV secretion system protein
IS495_RS04125	COG0189	ligase activity
IS495_RS04130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IS495_RS04135	COG2356	endonuclease I
IS495_RS04145	COG2814	Major facilitator Superfamily
IS495_RS04180	COG2146	nitrite reductase [NAD(P)H] activity
IS495_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS04200	COG1414	Transcriptional regulator
IS495_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS04235	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IS495_RS04260	COG0501	Belongs to the peptidase M48B family
IS495_RS04265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS495_RS04280	COG0191	fructose-bisphosphate aldolase activity
IS495_RS04285	COG0668	transmembrane transport
IS495_RS04295	COG2968	Membrane
IS495_RS04310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS495_RS04315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IS495_RS04335	COG0006	proline dipeptidase activity
IS495_RS04340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS495_RS04345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS495_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS04370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS495_RS04390	COG2723	6-phospho-beta-galactosidase activity
IS495_RS04395	COG1737	Transcriptional regulator
IS495_RS04405	COG1272	protein, Hemolysin III
IS495_RS04415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IS495_RS04425	COG0716	FMN binding
IS495_RS04430	COG4974	Belongs to the 'phage' integrase family
IS495_RS04440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IS495_RS04460	COG4942	peptidase
IS495_RS04470	COG2814	Major facilitator Superfamily
IS495_RS04485	COG0667	Aldo Keto reductase
IS495_RS04520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS495_RS04525	COG1393	Belongs to the ArsC family
IS495_RS04540	COG1538	Outer membrane efflux protein
IS495_RS04545	COG1289	transmembrane transporter activity
IS495_RS04560	COG3592	Divergent 4Fe-4S mono-cluster
IS495_RS04565	COG2388	GCN5-related N-acetyl-transferase
IS495_RS04575	COG3539	Fimbrial protein
IS495_RS04580	COG3539	Fimbrial protein
IS495_RS04585	COG3539	Fimbrial protein
IS495_RS04590	COG3188	usher protein
IS495_RS04595	COG3121	Chaperone
IS495_RS04600	COG3539	Fimbrial protein
IS495_RS04610	COG4974	Belongs to the 'phage' integrase family
IS495_RS04615	COG0582	viral genome integration into host DNA
IS495_RS04620	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS495_RS04625	COG1846	Transcriptional regulator
IS495_RS04630	COG0697	spore germination
IS495_RS04680	COG0667	Aldo Keto reductase
IS495_RS04685	COG0814	amino acid
IS495_RS04700	COG0183	Belongs to the thiolase family
IS495_RS04710	COG0823	Involved in the tonB-independent uptake of proteins
IS495_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS04720	COG2814	Major facilitator Superfamily
IS495_RS04755	COG3842	ATPase activity
IS495_RS04760	COG0395	ABC-type sugar transport system, permease component
IS495_RS04765	COG1175	transmembrane transport
IS495_RS04770	COG1917	Cupin 2, conserved barrel domain protein
IS495_RS04775	COG1794	racemase activity, acting on amino acids and derivatives
IS495_RS04780	COG0583	DNA-binding transcription factor activity
IS495_RS04790	COG1609	Transcriptional regulator
IS495_RS04795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS04800	COG2723	6-phospho-beta-galactosidase activity
IS495_RS04805	COG2186	Transcriptional regulator
IS495_RS04815	COG1609	Transcriptional regulator
IS495_RS04835	COG0667	Aldo Keto reductase
IS495_RS04845	COG0861	Integral membrane protein TerC family
IS495_RS04880	COG2165	general secretion pathway protein
IS495_RS04885	COG4795	General secretion pathway protein
IS495_RS04895	COG4967	type IV pilus modification protein PilV
IS495_RS04900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IS495_RS04905	COG1025	Belongs to the peptidase M16 family
IS495_RS04910	COG1074	ATP-dependent DNA helicase activity
IS495_RS04925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IS495_RS04925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IS495_RS04930	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS495_RS04935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS495_RS04965	COG4656	Part of a membrane complex involved in electron transport
IS495_RS04970	COG1454	alcohol dehydrogenase
IS495_RS04970	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS05000	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IS495_RS05165	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IS495_RS05170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IS495_RS05175	COG2166	iron-sulfur cluster assembly
IS495_RS05180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS495_RS05190	COG0583	DNA-binding transcription factor activity
IS495_RS05195	COG2363	Small membrane protein
IS495_RS05205	COG1349	DNA-binding transcription factor activity
IS495_RS05225	COG0738	Major facilitator superfamily
IS495_RS05230	COG0235	Class ii aldolase
IS495_RS05235	COG1454	alcohol dehydrogenase
IS495_RS05255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS495_RS05270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS495_RS05275	COG2011	ABC-type metal ion transport system permease component
IS495_RS05280	COG1464	Belongs to the NlpA lipoprotein family
IS495_RS05285	COG0477	Major facilitator Superfamily
IS495_RS05295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS495_RS05300	COG1760	l-serine dehydratase
IS495_RS05305	COG0814	amino acid
IS495_RS05310	COG1611	Belongs to the LOG family
IS495_RS05325	COG3098	single-species biofilm formation
IS495_RS05330	COG0564	pseudouridine synthase activity
IS495_RS05335	COG0716	FMN binding
IS495_RS05340	COG2271	Major facilitator Superfamily
IS495_RS05345	COG4948	Mandelate Racemase Muconate Lactonizing
IS495_RS05350	COG4948	Mandelate Racemase Muconate Lactonizing
IS495_RS05355	COG1929	Belongs to the glycerate kinase type-1 family
IS495_RS05360	COG4999	Histidine kinase
IS495_RS05360	COG2205	protein histidine kinase activity
IS495_RS05360	COG3437	response regulator, receiver
IS495_RS05360	COG3850	Histidine kinase
IS495_RS05370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS495_RS05375	COG3956	TIGRFAM MazG family protein
IS495_RS05395	COG0602	queuosine metabolic process
IS495_RS05400	COG0720	synthase
IS495_RS05420	COG2234	aminopeptidase activity
IS495_RS05480	COG4942	peptidase
IS495_RS05480	COG1388	LysM domain
IS495_RS05485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS495_RS05510	COG0163	prenyltransferase activity
IS495_RS05515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS495_RS05555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS05560	COG4558	Periplasmic binding protein
IS495_RS05565	COG3720	iron ion transport
IS495_RS05585	COG0679	Auxin Efflux Carrier
IS495_RS05600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS495_RS05605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS495_RS05610	COG1121	(ABC) transporter
IS495_RS05615	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS495_RS05620	COG1609	Transcriptional regulator
IS495_RS05625	COG1940	carbohydrate kinase activity
IS495_RS05630	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS495_RS05635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS05640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS05645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS05650	COG4580	involved in the transport of maltose and maltodextrins
IS495_RS05660	COG2723	6-phospho-beta-galactosidase activity
IS495_RS05670	COG0309	Hydrogenase expression formation protein (HypE)
IS495_RS05675	COG0409	Hydrogenase expression formation protein
IS495_RS05680	COG0298	carbon dioxide binding
IS495_RS05685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IS495_RS05700	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS495_RS05705	COG0651	ATP synthesis coupled electron transport
IS495_RS05710	COG0650	Formate hydrogenlyase subunit 4
IS495_RS05715	COG3261	NADH dehydrogenase
IS495_RS05715	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IS495_RS05720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS495_RS05725	COG3260	NADH ubiquinone oxidoreductase 20
IS495_RS05735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IS495_RS05745	COG2723	6-phospho-beta-galactosidase activity
IS495_RS05750	COG1263	PTS System
IS495_RS05750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS05755	COG1609	Transcriptional regulator
IS495_RS05760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS495_RS05765	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IS495_RS05770	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IS495_RS05795	COG1349	DNA-binding transcription factor activity
IS495_RS05800	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS05815	COG3732	PTS system glucitol sorbitol-specific
IS495_RS05820	COG3730	PTS system glucitol sorbitol-specific
IS495_RS05825	COG2951	lytic endotransglycosylase activity
IS495_RS05830	COG1121	(ABC) transporter
IS495_RS05835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS495_RS05845	COG1546	Belongs to the CinA family
IS495_RS05865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IS495_RS05895	COG2823	Periplasmic or secreted lipoprotein
IS495_RS05900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS495_RS05905	COG1238	metal cluster binding
IS495_RS05925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IS495_RS05930	COG2814	Major facilitator Superfamily
IS495_RS05935	COG1566	PFAM secretion protein HlyD family protein
IS495_RS05940	COG1846	Transcriptional regulator
IS495_RS05950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IS495_RS05960	COG4176	ABC-type proline glycine betaine transport system permease component
IS495_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS495_RS05985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS495_RS05990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS495_RS05995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS495_RS06000	COG4575	ribosome binding
IS495_RS06015	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS495_RS06030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS495_RS06035	COG0640	Transcriptional regulator
IS495_RS06045	COG0583	DNA-binding transcription factor activity
IS495_RS06050	COG3284	Transcriptional regulator
IS495_RS06065	COG4974	Belongs to the 'phage' integrase family
IS495_RS06100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS495_RS06115	COG3344	reverse transcriptase
IS495_RS06150	COG4695	Portal protein
IS495_RS06315	COG2867	negative regulation of translational initiation
IS495_RS06330	COG0497	DNA recombination
IS495_RS06345	COG4536	flavin adenine dinucleotide binding
IS495_RS06350	COG4137	Cytochrome C assembly protein
IS495_RS06355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IS495_RS06390	COG2885	chlorophyll binding
IS495_RS06395	COG2199	diguanylate cyclase activity
IS495_RS06405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS495_RS06410	COG1605	Chorismate mutase
IS495_RS06410	COG0287	Prephenate dehydrogenase
IS495_RS06420	COG0077	Prephenate dehydratase
IS495_RS06420	COG1605	Chorismate mutase
IS495_RS06430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS495_RS06435	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS495_RS06450	COG0542	response to heat
IS495_RS06475	COG0477	Major facilitator Superfamily
IS495_RS06480	COG5544	Lipoprotein
IS495_RS06485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS495_RS06495	COG3148	PFAM DTW domain containing protein
IS495_RS06500	COG3118	belongs to the thioredoxin family
IS495_RS06505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS495_RS06520	COG0513	Belongs to the DEAD box helicase family
IS495_RS06530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IS495_RS06545	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IS495_RS06550	COG3026	antisigma factor binding
IS495_RS06555	COG3086	response to oxidative stress
IS495_RS06565	COG0681	Belongs to the peptidase S26 family
IS495_RS06585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS495_RS06595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS495_RS06600	COG1737	Transcriptional regulator
IS495_RS06605	COG0560	Phosphoserine phosphatase
IS495_RS06620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IS495_RS06620	COG0047	phosphoribosylformylglycinamidine synthase activity
IS495_RS06625	COG2205	protein histidine kinase activity
IS495_RS06630	COG3170	Tfp pilus assembly protein FimV
IS495_RS06635	COG2204	response regulator
IS495_RS06640	COG0347	Belongs to the P(II) protein family
IS495_RS06645	COG1017	nitric oxide dioxygenase activity
IS495_RS06645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS495_RS06655	COG2259	Doxx family
IS495_RS06660	COG1940	carbohydrate kinase activity
IS495_RS06665	COG0457	Tetratricopeptide repeat
IS495_RS06670	COG2814	Major facilitator Superfamily
IS495_RS06670	COG0477	Major facilitator Superfamily
IS495_RS06675	COG2017	converts alpha-aldose to the beta-anomer
IS495_RS06680	COG2814	Major facilitator Superfamily
IS495_RS06685	COG3711	transcriptional antiterminator
IS495_RS06690	COG3683	transport system, periplasmic component
IS495_RS06695	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS495_RS06730	COG0822	iron-sulfur transferase activity
IS495_RS06750	COG0633	Ferredoxin
IS495_RS06755	COG2975	iron-sulfur cluster assembly
IS495_RS06775	COG2897	thiosulfate sulfurtransferase activity
IS495_RS06780	COG2373	Large extracellular alpha-helical protein
IS495_RS06785	COG4953	penicillin-binding protein 1C
IS495_RS06815	COG2976	Protein conserved in bacteria
IS495_RS06835	COG1645	bacterial-type flagellum-dependent swarming motility
IS495_RS06845	COG0516	GMP reductase activity
IS495_RS06845	COG0517	IMP dehydrogenase activity
IS495_RS06890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS495_RS06975	COG5484	DNA packaging
IS495_RS06975	COG3728	DNA packaging
IS495_RS07065	COG3617	BRO family, N-terminal domain
IS495_RS07095	COG3179	chitinase
IS495_RS07105	COG3119	arylsulfatase activity
IS495_RS07110	COG0641	radical SAM
IS495_RS07130	COG2200	EAL domain
IS495_RS07145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IS495_RS07160	COG2723	6-phospho-beta-galactosidase activity
IS495_RS07170	COG2233	PERMEase
IS495_RS07185	COG1393	Belongs to the ArsC family
IS495_RS07190	COG4783	chaperone-mediated protein folding
IS495_RS07200	COG0628	permease
IS495_RS07205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IS495_RS07210	COG2716	regulation of RNA biosynthetic process
IS495_RS07220	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IS495_RS07230	COG2321	neutral zinc metallopeptidase
IS495_RS07235	COG1444	tRNA N-acetyltransferase activity
IS495_RS07240	COG0400	carboxylic ester hydrolase activity
IS495_RS07255	COG1393	Belongs to the ArsC family
IS495_RS07265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS495_RS07270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS495_RS07270	COG0493	'glutamate synthase
IS495_RS07280	COG5342	invasion associated locus B
IS495_RS07285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS495_RS07290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS495_RS07300	COG4810	utilization protein
IS495_RS07390	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS495_RS07410	COG2837	iron assimilation
IS495_RS07420	COG4150	thiosulfate binding
IS495_RS07425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IS495_RS07430	COG4208	sulfate ABC transporter
IS495_RS07435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IS495_RS07445	COG4319	ketosteroid isomerase
IS495_RS07480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IS495_RS07500	COG3530	Putative quorum-sensing-regulated virulence factor
IS495_RS07505	COG0385	Bile acid
IS495_RS07510	COG0583	DNA-binding transcription factor activity
IS495_RS07540	COG3415	Transposase
IS495_RS07545	COG3415	Transposase
IS495_RS07560	COG2200	EAL domain
IS495_RS07560	COG2199	diguanylate cyclase activity
IS495_RS07565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS495_RS07580	COG0667	Aldo Keto reductase
IS495_RS07585	COG3961	Belongs to the TPP enzyme family
IS495_RS07600	COG3279	Response regulator of the LytR AlgR family
IS495_RS07605	COG3275	phosphorelay sensor kinase activity
IS495_RS07620	COG0436	Aminotransferase
IS495_RS07630	COG2807	transmembrane transport
IS495_RS07635	COG0590	tRNA wobble adenosine to inosine editing
IS495_RS07640	COG0583	DNA-binding transcription factor activity
IS495_RS07660	COG2116	formate transmembrane transporter activity
IS495_RS07665	COG2853	Lipoprotein
IS495_RS07675	COG3691	Protein conserved in bacteria
IS495_RS07690	COG2062	phosphohistidine phosphatase, SixA
IS495_RS07715	COG0730	response to heat
IS495_RS07720	COG3101	peptidyl-lysine hydroxylation
IS495_RS07735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS495_RS07755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS495_RS07765	COG0586	Pfam SNARE associated Golgi protein
IS495_RS07775	COG0285	dihydrofolate synthase activity
IS495_RS07780	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IS495_RS07785	COG1286	toxin biosynthetic process
IS495_RS07790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IS495_RS07795	COG0163	prenyltransferase activity
IS495_RS07820	COG4160	amino acid transport
IS495_RS07825	COG4598	ABC transporter
IS495_RS07840	COG1090	epimerase
IS495_RS07845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS495_RS07850	COG0625	glutathione transferase activity
IS495_RS07855	COG0625	glutathione transferase activity
IS495_RS07860	COG0622	Phosphoesterase
IS495_RS07865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IS495_RS07870	COG0857	belongs to the CobB CobQ family
IS495_RS07870	COG0280	phosphate acetyltransferase
IS495_RS07890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS495_RS07895	COG0471	metal ion transport
IS495_RS07895	COG0490	domain, Protein
IS495_RS07905	COG0436	Aminotransferase
IS495_RS07910	COG0583	DNA-binding transcription factor activity
IS495_RS07955	COG0839	Belongs to the complex I subunit 6 family
IS495_RS07965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IS495_RS07970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS495_RS07985	COG2153	protein acetylation
IS495_RS07990	COG1169	isochorismate synthase
IS495_RS08015	COG0318	PFAM AMP-dependent synthetase and ligase
IS495_RS08025	COG5464	transposase or invertase
IS495_RS08040	COG1414	Transcriptional regulator
IS495_RS08050	COG2271	Major facilitator Superfamily
IS495_RS08060	COG0247	lactate metabolic process
IS495_RS08070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS495_RS08080	COG2271	Major facilitator Superfamily
IS495_RS08085	COG0584	glycerophosphoryl diester phosphodiesterase
IS495_RS08090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS495_RS08115	COG2205	protein histidine kinase activity
IS495_RS08115	COG0784	Response regulator, receiver
IS495_RS08125	COG0642	Histidine kinase
IS495_RS08125	COG2198	Histidine kinase
IS495_RS08140	COG2169	Transcriptional regulator
IS495_RS08140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS495_RS08145	COG3145	DNA-N1-methyladenine dioxygenase activity
IS495_RS08150	COG4615	Cyclic peptide transporter
IS495_RS08155	COG2239	Acts as a magnesium transporter
IS495_RS08160	COG0659	secondary active sulfate transmembrane transporter activity
IS495_RS08175	COG0628	permease
IS495_RS08200	COG1349	DNA-binding transcription factor activity
IS495_RS08205	COG0494	nUDIX hydrolase
IS495_RS08225	COG1061	Type III restriction enzyme res subunit
IS495_RS08230	COG1187	pseudouridine synthase activity
IS495_RS08235	COG2814	Major facilitator Superfamily
IS495_RS08245	COG4172	Belongs to the ABC transporter superfamily
IS495_RS08250	COG4239	(ABC) transporter, permease
IS495_RS08255	COG4174	ABC transporter (Permease)
IS495_RS08260	COG4166	transmembrane transport
IS495_RS08265	COG2200	EAL domain
IS495_RS08270	COG0791	NLP P60 protein
IS495_RS08275	COG0671	phosphoesterase, PA-phosphatase related
IS495_RS08280	COG0523	cobalamin synthesis protein
IS495_RS08285	COG0246	Mannitol dehydrogenase
IS495_RS08290	COG1312	Catalyzes the dehydration of D-mannonate
IS495_RS08315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS08315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS08320	COG1105	Belongs to the carbohydrate kinase PfkB family
IS495_RS08325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS495_RS08325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS495_RS08325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS495_RS08335	COG2855	membrane
IS495_RS08340	COG0583	DNA-binding transcription factor activity
IS495_RS08345	COG0833	amino acid
IS495_RS08355	COG4771	TonB-dependent receptor
IS495_RS08370	COG2311	Membrane
IS495_RS08385	COG1129	ABC transporter
IS495_RS08395	COG2949	membrane
IS495_RS08405	COG1346	cytolysis
IS495_RS08415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS495_RS08420	COG3659	wide pore channel activity
IS495_RS08435	COG2723	6-phospho-beta-galactosidase activity
IS495_RS08440	COG1538	Outer membrane efflux protein
IS495_RS08445	COG0586	Pfam SNARE associated Golgi protein
IS495_RS08455	COG1686	Belongs to the peptidase S11 family
IS495_RS08470	COG0277	FAD linked oxidase domain protein
IS495_RS08475	COG1472	Belongs to the glycosyl hydrolase 3 family
IS495_RS08480	COG1732	Glycine betaine
IS495_RS08485	COG1174	glycine betaine transport
IS495_RS08490	COG1125	glycine betaine transport
IS495_RS08495	COG1174	glycine betaine transport
IS495_RS08505	COG3275	phosphorelay sensor kinase activity
IS495_RS08515	COG4807	Protein conserved in bacteria
IS495_RS08535	COG5455	response to cobalt ion
IS495_RS08540	COG0583	DNA-binding transcription factor activity
IS495_RS08545	COG2252	PERMEase
IS495_RS08555	COG0583	DNA-binding transcription factor activity
IS495_RS08570	COG0351	phosphomethylpyrimidine kinase
IS495_RS08575	COG1830	Aldolase
IS495_RS08585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS495_RS08610	COG1070	Carbohydrate kinase
IS495_RS08620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS495_RS08625	COG4948	Mandelate Racemase Muconate Lactonizing
IS495_RS08630	COG0747	negative chemotaxis
IS495_RS08635	COG0601	transmembrane transport
IS495_RS08640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS495_RS08645	COG0444	Belongs to the ABC transporter superfamily
IS495_RS08650	COG4608	Belongs to the ABC transporter superfamily
IS495_RS08660	COG0826	peptidase U32
IS495_RS08665	COG0745	RESPONSE REGULATOR receiver
IS495_RS08670	COG2205	protein histidine kinase activity
IS495_RS08695	COG1301	dicarboxylic acid transport
IS495_RS08715	COG5002	protein histidine kinase activity
IS495_RS08720	COG0443	Heat shock 70 kDa protein
IS495_RS08725	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IS495_RS08740	COG2982	Protein involved in outer membrane biogenesis
IS495_RS08745	COG1253	flavin adenine dinucleotide binding
IS495_RS08800	COG1215	transferase activity, transferring glycosyl groups
IS495_RS08810	COG0438	transferase activity, transferring glycosyl groups
IS495_RS08845	COG1088	dTDP-glucose 4,6-dehydratase activity
IS495_RS08870	COG3039	Transposase
IS495_RS08920	COG0438	transferase activity, transferring glycosyl groups
IS495_RS08925	COG1215	transferase activity, transferring glycosyl groups
IS495_RS08945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IS495_RS08975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS495_RS08980	COG0583	DNA-binding transcription factor activity
IS495_RS08990	COG0531	amino acid
IS495_RS08995	COG0640	Transcriptional regulator
IS495_RS09000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS495_RS09010	COG2925	Exonuclease
IS495_RS09020	COG3344	reverse transcriptase
IS495_RS09030	COG1289	transmembrane transporter activity
IS495_RS09050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IS495_RS09060	COG1942	4-Oxalocrotonate Tautomerase
IS495_RS09065	COG0583	DNA-binding transcription factor activity
IS495_RS09070	COG0095	Lipoate-protein ligase
IS495_RS09075	COG0477	Major facilitator Superfamily
IS495_RS09085	COG5001	Diguanylate cyclase
IS495_RS09085	COG3300	MHYT domain
IS495_RS09095	COG3615	Tellurite resistance protein tehB
IS495_RS09120	COG3706	GGDEF domain
IS495_RS09170	COG2003	Belongs to the UPF0758 family
IS495_RS09215	COG3504	Conjugal transfer protein
IS495_RS09285	COG4771	TonB-dependent receptor
IS495_RS09290	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS495_RS09310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS495_RS09310	COG3433	isochorismatase activity
IS495_RS09310	COG2226	methyltransferase
IS495_RS09325	COG1132	(ABC) transporter
IS495_RS09330	COG2814	Major facilitator Superfamily
IS495_RS09335	COG1169	isochorismate synthase
IS495_RS09340	COG0582	viral genome integration into host DNA
IS495_RS09350	COG0534	Mate efflux family protein
IS495_RS09360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IS495_RS09380	COG0604	alcohol dehydrogenase
IS495_RS09390	COG0025	NhaP-type Na H and K H
IS495_RS09435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS495_RS09445	COG1418	mRNA catabolic process
IS495_RS09450	COG0270	DNA (cytosine-5-)-methyltransferase activity
IS495_RS09455	COG3727	T/G mismatch-specific endonuclease activity
IS495_RS09460	COG0697	spore germination
IS495_RS09465	COG2354	Protein conserved in bacteria
IS495_RS09495	COG0366	Alpha amylase catalytic
IS495_RS09500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS09510	COG0765	amino acid transport
IS495_RS09515	COG1126	abc transporter atp-binding protein
IS495_RS09520	COG2197	response regulator
IS495_RS09530	COG2197	response regulator
IS495_RS09565	COG3012	SEC-C Motif Domain Protein
IS495_RS09565	COG3318	Belongs to the UPF0149 family
IS495_RS09570	COG0814	amino acid
IS495_RS09580	COG1528	Iron-storage protein
IS495_RS09595	COG0477	Major facilitator Superfamily
IS495_RS09605	COG2211	Major facilitator Superfamily
IS495_RS09615	COG1528	Iron-storage protein
IS495_RS09625	COG1879	ABC-type sugar transport system periplasmic component
IS495_RS09635	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS09660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IS495_RS09670	COG3102	Protein conserved in bacteria
IS495_RS09690	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IS495_RS09695	COG1801	Protein of unknown function DUF72
IS495_RS09700	COG1335	isochorismatase
IS495_RS09710	COG0494	nUDIX hydrolase
IS495_RS09735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS495_RS09745	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IS495_RS09750	COG0739	heme binding
IS495_RS09755	COG1560	Kdo2-lipid A biosynthetic process
IS495_RS09765	COG1737	Transcriptional regulator
IS495_RS09775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS495_RS09780	COG0129	dihydroxy-acid dehydratase activity
IS495_RS09785	COG0800	Aldolase
IS495_RS09795	COG3141	response to X-ray
IS495_RS09800	COG2979	Protein of unknown function (DUF533)
IS495_RS09805	COG1770	oligopeptidase
IS495_RS09810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS495_RS09820	COG2372	response to copper ion
IS495_RS09825	COG1276	copper resistance
IS495_RS09840	COG2990	Protein conserved in bacteria
IS495_RS09865	COG3008	intermembrane lipid transfer
IS495_RS09870	COG2995	paraquat-inducible protein a
IS495_RS09875	COG1956	GAF domain-containing protein
IS495_RS09895	COG2814	Major facilitator Superfamily
IS495_RS09900	COG1414	Transcriptional regulator
IS495_RS09930	COG0768	penicillin binding
IS495_RS09935	COG2226	methyltransferase
IS495_RS09950	COG3716	PTS system mannose fructose sorbose family IID component
IS495_RS09955	COG3715	PTS system
IS495_RS09960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS09960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS09965	COG1253	flavin adenine dinucleotide binding
IS495_RS09970	COG2200	EAL domain
IS495_RS09975	COG1760	l-serine dehydratase
IS495_RS09995	COG0251	oxidation-reduction process
IS495_RS10000	COG1199	ATP-dependent helicase activity
IS495_RS10010	COG3065	identical protein binding
IS495_RS10020	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IS495_RS10030	COG2894	cell division
IS495_RS10045	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS495_RS10075	COG2719	SpoVR family
IS495_RS10100	COG1619	proteins homologs of microcin C7 resistance protein MccF
IS495_RS10110	COG4774	siderophore transport
IS495_RS10125	COG2308	Evidence 4 Homologs of previously reported genes of
IS495_RS10165	COG0583	DNA-binding transcription factor activity
IS495_RS10170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS495_RS10185	COG1882	Formate acetyltransferase
IS495_RS10220	COG0583	DNA-binding transcription factor activity
IS495_RS10250	COG0583	DNA-binding transcription factor activity
IS495_RS10265	COG3122	Protein conserved in bacteria
IS495_RS10285	COG2885	chlorophyll binding
IS495_RS10435	COG0012	GTP binding
IS495_RS10455	COG0659	secondary active sulfate transmembrane transporter activity
IS495_RS10485	COG2890	protein-(glutamine-N5) methyltransferase activity
IS495_RS10505	COG0387	Pfam Sodium calcium exchanger
IS495_RS10510	COG4572	Cation transport regulator
IS495_RS10515	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IS495_RS10525	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IS495_RS10530	COG3707	response regulator
IS495_RS10535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS495_RS10545	COG1116	anion transmembrane transporter activity
IS495_RS10550	COG2146	nitrite reductase [NAD(P)H] activity
IS495_RS10550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS495_RS10555	COG0243	molybdopterin cofactor binding
IS495_RS10560	COG4932	domain protein
IS495_RS10565	COG2197	response regulator
IS495_RS10570	COG3850	Histidine kinase
IS495_RS10575	COG2223	nitrite transmembrane transporter activity
IS495_RS10585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS495_RS10590	COG1140	nitrate reductase beta subunit
IS495_RS10595	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS495_RS10600	COG2181	nitrate reductase activity
IS495_RS10610	COG1522	sequence-specific DNA binding
IS495_RS10645	COG0788	formyltetrahydrofolate deformylase activity
IS495_RS10655	COG1752	Esterase of the alpha-beta hydrolase superfamily
IS495_RS10660	COG0745	RESPONSE REGULATOR receiver
IS495_RS10665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IS495_RS10670	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS495_RS10680	COG1435	thymidine kinase activity
IS495_RS10685	COG1454	alcohol dehydrogenase
IS495_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS10695	COG2095	MarC family integral membrane protein
IS495_RS10700	COG4166	transmembrane transport
IS495_RS10705	COG0601	transmembrane transport
IS495_RS10710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS495_RS10715	COG0444	Belongs to the ABC transporter superfamily
IS495_RS10725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS495_RS10745	COG2353	YceI-like domain
IS495_RS10755	COG2350	Protein conserved in bacteria
IS495_RS10765	COG3001	Fructosamine kinase
IS495_RS10775	COG1105	Belongs to the carbohydrate kinase PfkB family
IS495_RS10780	COG3137	Salt-induced outer membrane protein
IS495_RS10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS495_RS10820	COG0072	phenylalanine-tRNA ligase activity
IS495_RS10840	COG0583	DNA-binding transcription factor activity
IS495_RS10860	COG0386	Belongs to the glutathione peroxidase family
IS495_RS10870	COG0791	NLP P60 protein
IS495_RS10880	COG4256	Hemin uptake protein
IS495_RS10885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS495_RS10900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS495_RS10900	COG0574	Belongs to the PEP-utilizing enzyme family
IS495_RS10910	COG0628	permease
IS495_RS10915	COG0247	lactate metabolic process
IS495_RS10915	COG0277	FAD linked oxidase domain protein
IS495_RS10920	COG2050	protein possibly involved in aromatic compounds catabolism
IS495_RS10925	COG2261	transglycosylase associated protein
IS495_RS10950	COG1120	ATPase activity
IS495_RS10955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS10965	COG0583	DNA-binding transcription factor activity
IS495_RS10990	COG1304	FMN binding
IS495_RS10995	COG1309	transcriptional regulator
IS495_RS11015	COG0316	Belongs to the HesB IscA family
IS495_RS11020	COG0719	Fe-S assembly protein
IS495_RS11025	COG0396	ATPase activity
IS495_RS11030	COG0719	Fe-S assembly protein
IS495_RS11045	COG1376	ErfK ybiS ycfS ynhG family protein
IS495_RS11075	COG1309	transcriptional regulator
IS495_RS11080	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IS495_RS11080	COG1082	Xylose isomerase domain protein TIM barrel
IS495_RS11085	COG2271	Major facilitator Superfamily
IS495_RS11090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS495_RS11100	COG1120	ATPase activity
IS495_RS11105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS11110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS495_RS11115	COG1414	Transcriptional regulator
IS495_RS11150	COG2814	Major facilitator Superfamily
IS495_RS11170	COG0583	DNA-binding transcription factor activity
IS495_RS11175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS495_RS11195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS495_RS11200	COG1116	anion transmembrane transporter activity
IS495_RS11205	COG4774	siderophore transport
IS495_RS11210	COG1120	ATPase activity
IS495_RS11215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS11220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS11240	COG0765	amino acid transport
IS495_RS11245	COG1126	abc transporter atp-binding protein
IS495_RS11285	COG3383	formate dehydrogenase (NAD+) activity
IS495_RS11290	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IS495_RS11300	COG1175	transmembrane transport
IS495_RS11330	COG4133	protoheme IX ABC transporter activity
IS495_RS11335	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS495_RS11340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS495_RS11355	COG1138	Cytochrome C-type biogenesis protein
IS495_RS11360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS495_RS11365	COG4235	cytochrome complex assembly
IS495_RS11365	COG3088	subunit of a heme lyase
IS495_RS11385	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IS495_RS11420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS495_RS11455	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS11460	COG2610	gluconate transmembrane transporter activity
IS495_RS11465	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS495_RS11475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS495_RS11485	COG0583	DNA-binding transcription factor activity
IS495_RS11510	COG0277	FAD linked oxidase domain protein
IS495_RS11515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS495_RS11540	COG0402	S-adenosylhomocysteine deaminase activity
IS495_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS11585	COG0604	alcohol dehydrogenase
IS495_RS11585	COG3321	synthase
IS495_RS11615	COG4608	Belongs to the ABC transporter superfamily
IS495_RS11620	COG0444	Belongs to the ABC transporter superfamily
IS495_RS11645	COG0346	lactoylglutathione lyase activity
IS495_RS11650	COG1349	DNA-binding transcription factor activity
IS495_RS11685	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IS495_RS11735	COG0307	riboflavin synthase, alpha
IS495_RS11740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS495_RS11745	COG2814	Major facilitator Superfamily
IS495_RS11750	COG0583	DNA-binding transcription factor activity
IS495_RS11765	COG2814	Major facilitator Superfamily
IS495_RS11780	COG0791	NLP P60 protein
IS495_RS11785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS495_RS11795	COG0346	lactoylglutathione lyase activity
IS495_RS11800	COG1902	pentaerythritol trinitrate reductase activity
IS495_RS11805	COG1309	transcriptional regulator
IS495_RS11810	COG3313	Fe-S protein
IS495_RS11815	COG4989	oxidoreductase activity
IS495_RS11820	COG2032	superoxide dismutase activity
IS495_RS11825	COG1289	transmembrane transporter activity
IS495_RS11830	COG1566	PFAM secretion protein HlyD family protein
IS495_RS11845	COG3706	GGDEF domain
IS495_RS11860	COG3895	Periplasmic Protein
IS495_RS11875	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IS495_RS11880	COG0625	glutathione transferase activity
IS495_RS11890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IS495_RS11900	COG4659	FMN binding
IS495_RS11935	COG2723	6-phospho-beta-galactosidase activity
IS495_RS11945	COG0673	inositol 2-dehydrogenase activity
IS495_RS11955	COG2814	Major facilitator Superfamily
IS495_RS11975	COG3038	cytochrome b561
IS495_RS11995	COG0583	DNA-binding transcription factor activity
IS495_RS12000	COG3485	protocatechuate 3,4-dioxygenase
IS495_RS12005	COG3485	protocatechuate 3,4-dioxygenase
IS495_RS12010	COG5383	Protein conserved in bacteria
IS495_RS12015	COG2272	Belongs to the type-B carboxylesterase lipase family
IS495_RS12030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS495_RS12035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS495_RS12040	COG1275	C4-dicarboxylate transporter malic acid transport protein
IS495_RS12045	COG0500	methyltransferase
IS495_RS12060	COG3708	Transcriptional regulator
IS495_RS12060	COG2207	Transcriptional regulator
IS495_RS12065	COG3135	benzoate transporter
IS495_RS12070	COG1396	sequence-specific DNA binding
IS495_RS12080	COG0826	peptidase U32
IS495_RS12100	COG1294	oxidase, subunit
IS495_RS12105	COG1271	oxidase subunit
IS495_RS12110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS495_RS12115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS495_RS12120	COG3842	ATPase activity
IS495_RS12125	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS495_RS12130	COG1177	transmembrane transport
IS495_RS12135	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS12170	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS12175	COG0747	negative chemotaxis
IS495_RS12185	COG3238	Protein conserved in bacteria
IS495_RS12190	COG1247	-acetyltransferase
IS495_RS12200	COG2130	NADP-dependent
IS495_RS12215	COG3691	Protein conserved in bacteria
IS495_RS12220	COG1228	amidohydrolase
IS495_RS12225	COG4772	TonB-dependent receptor
IS495_RS12250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS495_RS12255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS495_RS12260	COG1473	amidohydrolase
IS495_RS12265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS495_RS12270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS12280	COG0765	amino acid transport
IS495_RS12285	COG1126	abc transporter atp-binding protein
IS495_RS12295	COG0625	glutathione transferase activity
IS495_RS12330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS495_RS12335	COG3842	ATPase activity
IS495_RS12340	COG1840	ABC-type Fe3 transport system, periplasmic component
IS495_RS12345	COG1178	ABC-type Fe3 transport system permease component
IS495_RS12350	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IS495_RS12355	COG2181	nitrate reductase activity
IS495_RS12360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IS495_RS12365	COG1140	nitrate reductase beta subunit
IS495_RS12370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IS495_RS12390	COG1414	Transcriptional regulator
IS495_RS12395	COG4948	Mandelate Racemase Muconate Lactonizing
IS495_RS12400	COG4829	muconolactone delta-isomerase
IS495_RS12405	COG3485	protocatechuate 3,4-dioxygenase
IS495_RS12415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IS495_RS12440	COG0437	4 iron, 4 sulfur cluster binding
IS495_RS12445	COG2864	formate dehydrogenase
IS495_RS12460	COG2326	polyphosphate kinase activity
IS495_RS12470	COG2814	Major facilitator Superfamily
IS495_RS12480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS495_RS12490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS495_RS12500	COG0747	negative chemotaxis
IS495_RS12505	COG1064	alcohol dehydrogenase
IS495_RS12520	COG0488	(ABC) transporter
IS495_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS12570	COG3729	General stress protein
IS495_RS12580	COG3685	Protein conserved in bacteria
IS495_RS12590	COG0366	Alpha amylase catalytic
IS495_RS12600	COG2323	membrane
IS495_RS12610	COG3111	PFAM Bacterial OB fold (BOF) protein
IS495_RS12620	COG1764	response to oxidative stress
IS495_RS12645	COG3781	membrane
IS495_RS12650	COG0243	molybdopterin cofactor binding
IS495_RS12655	COG0583	DNA-binding transcription factor activity
IS495_RS12660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS12685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS12690	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS495_RS12695	COG2814	Major facilitator Superfamily
IS495_RS12700	COG1285	pathogenesis
IS495_RS12705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS495_RS12715	COG0583	DNA-binding transcription factor activity
IS495_RS12735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS495_RS12735	COG0519	Catalyzes the synthesis of GMP from XMP
IS495_RS12775	COG0596	Alpha beta hydrolase
IS495_RS12785	COG2205	protein histidine kinase activity
IS495_RS12800	COG0076	glutamate decarboxylase activity
IS495_RS12805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS495_RS12810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS495_RS12815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS495_RS12820	COG1116	anion transmembrane transporter activity
IS495_RS12825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IS495_RS12840	COG0673	inositol 2-dehydrogenase activity
IS495_RS12850	COG1609	Transcriptional regulator
IS495_RS12855	COG3706	GGDEF domain
IS495_RS12860	COG0402	S-adenosylhomocysteine deaminase activity
IS495_RS12865	COG1953	Uracil, thiamine, allantoin
IS495_RS12905	COG0406	alpha-ribazole phosphatase activity
IS495_RS12910	COG1335	isochorismatase
IS495_RS12940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS495_RS13010	COG0765	amino acid transport
IS495_RS13020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IS495_RS13030	COG2070	2-Nitropropane dioxygenase
IS495_RS13035	COG0583	DNA-binding transcription factor activity
IS495_RS13045	COG1902	pentaerythritol trinitrate reductase activity
IS495_RS13050	COG4529	Protein conserved in bacteria
IS495_RS13055	COG0477	Major facilitator Superfamily
IS495_RS13085	COG2223	nitrite transmembrane transporter activity
IS495_RS13095	COG1609	Transcriptional regulator
IS495_RS13100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS13110	COG3037	sugar-specific permease SgaT UlaA
IS495_RS13115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS495_RS13125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS495_RS13130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS495_RS13130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS495_RS13130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS495_RS13145	COG0583	DNA-binding transcription factor activity
IS495_RS13150	COG0583	DNA-binding transcription factor activity
IS495_RS13155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS495_RS13165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS495_RS13180	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS13190	COG1609	Transcriptional regulator
IS495_RS13220	COG1652	LysM domain
IS495_RS13235	COG0426	domain, Protein
IS495_RS13235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS495_RS13260	COG0456	acetyltransferase
IS495_RS13260	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IS495_RS13270	COG0667	Aldo Keto reductase
IS495_RS13275	COG0667	Aldo Keto reductase
IS495_RS13285	COG0667	Aldo Keto reductase
IS495_RS13305	COG4977	sequence-specific DNA binding
IS495_RS13325	COG4977	sequence-specific DNA binding
IS495_RS13330	COG1349	DNA-binding transcription factor activity
IS495_RS13345	COG1349	DNA-binding transcription factor activity
IS495_RS13350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS495_RS13355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS13360	COG0738	Major facilitator superfamily
IS495_RS13405	COG1929	Belongs to the glycerate kinase type-1 family
IS495_RS13410	COG3835	regulator
IS495_RS13430	COG2186	Transcriptional regulator
IS495_RS13435	COG1263	PTS System
IS495_RS13435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS13445	COG2814	Major facilitator Superfamily
IS495_RS13450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS13450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS13465	COG2819	hydrolase of the alpha beta superfamily
IS495_RS13470	COG3300	MHYT domain
IS495_RS13470	COG5001	Diguanylate cyclase
IS495_RS13505	COG3188	usher protein
IS495_RS13515	COG1649	PFAM Uncharacterised BCR, COG1649
IS495_RS13520	COG3550	peptidyl-serine autophosphorylation
IS495_RS13525	COG1396	sequence-specific DNA binding
IS495_RS13530	COG2351	hydroxyisourate hydrolase activity
IS495_RS13535	COG3195	allantoin biosynthetic process
IS495_RS13535	COG3648	Uricase
IS495_RS13540	COG2233	PERMEase
IS495_RS13570	COG2207	Transcriptional regulator
IS495_RS13585	COG4628	conserved protein (DUF2132)
IS495_RS13605	COG2011	ABC-type metal ion transport system permease component
IS495_RS13610	COG2070	2-Nitropropane dioxygenase
IS495_RS13620	COG0477	Major facilitator Superfamily
IS495_RS13690	COG2199	diguanylate cyclase activity
IS495_RS13705	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS13710	COG0583	DNA-binding transcription factor activity
IS495_RS13720	COG0039	L-malate dehydrogenase activity
IS495_RS13725	COG1349	DNA-binding transcription factor activity
IS495_RS13730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS495_RS13735	COG3395	kinase activity
IS495_RS13745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS495_RS13760	COG2731	YhcH YjgK YiaL family protein
IS495_RS13765	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS13795	COG4977	sequence-specific DNA binding
IS495_RS13805	COG0697	spore germination
IS495_RS13810	COG2814	Major facilitator Superfamily
IS495_RS13820	COG0410	ABC transporter
IS495_RS13825	COG1129	ABC transporter
IS495_RS13840	COG0683	leucine binding
IS495_RS13845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IS495_RS13880	COG2223	nitrite transmembrane transporter activity
IS495_RS13885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IS495_RS13900	COG1349	DNA-binding transcription factor activity
IS495_RS13905	COG2084	Dehydrogenase
IS495_RS13910	COG3395	kinase activity
IS495_RS13915	COG0235	Class ii aldolase
IS495_RS13920	COG3622	Belongs to the hyi family
IS495_RS13925	COG2610	gluconate transmembrane transporter activity
IS495_RS13930	COG2207	Transcriptional regulator
IS495_RS13930	COG3708	Transcriptional regulator
IS495_RS13945	COG2200	EAL domain
IS495_RS13950	COG1546	Belongs to the CinA family
IS495_RS13955	COG0071	Belongs to the small heat shock protein (HSP20) family
IS495_RS13970	COG2197	response regulator
IS495_RS13985	COG2135	peptidase activity
IS495_RS13990	COG2207	Transcriptional regulator
IS495_RS14005	COG4221	oxidoreductase activity
IS495_RS14010	COG1802	Transcriptional regulator
IS495_RS14015	COG0589	response to stress
IS495_RS14020	COG0246	Mannitol dehydrogenase
IS495_RS14025	COG2271	Major facilitator Superfamily
IS495_RS14040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS495_RS14055	COG0243	molybdopterin cofactor binding
IS495_RS14060	COG0437	4 iron, 4 sulfur cluster binding
IS495_RS14065	COG3302	dmso reductase anchor subunit
IS495_RS14080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IS495_RS14085	COG1940	carbohydrate kinase activity
IS495_RS14090	COG0583	DNA-binding transcription factor activity
IS495_RS14095	COG2814	Major facilitator Superfamily
IS495_RS14100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IS495_RS14110	COG3591	Belongs to the peptidase S1B family
IS495_RS14130	COG0628	permease
IS495_RS14160	COG0679	Auxin Efflux Carrier
IS495_RS14170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS495_RS14195	COG3290	protein histidine kinase activity
IS495_RS14200	COG4565	transcriptional regulatory protein
IS495_RS14220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS495_RS14220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS495_RS14230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS495_RS14235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IS495_RS14245	COG0183	Belongs to the thiolase family
IS495_RS14250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IS495_RS14260	COG1414	Transcriptional regulator
IS495_RS14265	COG2840	Smr protein MutS2
IS495_RS14270	COG0583	DNA-binding transcription factor activity
IS495_RS14280	COG1473	amidohydrolase
IS495_RS14285	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IS495_RS14300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS495_RS14315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IS495_RS14320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IS495_RS14335	COG0531	amino acid
IS495_RS14345	COG3136	membrane protein required for alginate biosynthesis
IS495_RS14350	COG0745	RESPONSE REGULATOR receiver
IS495_RS14360	COG2205	protein histidine kinase activity
IS495_RS14370	COG0114	fumarate hydratase activity
IS495_RS14375	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IS495_RS14375	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IS495_RS14380	COG1482	cell wall glycoprotein biosynthetic process
IS495_RS14385	COG5339	Protein conserved in bacteria
IS495_RS14390	COG1609	Transcriptional regulator
IS495_RS14395	COG1263	PTS System
IS495_RS14395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS14400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS495_RS14425	COG2391	methyltransferase activity
IS495_RS14430	COG0425	Belongs to the sulfur carrier protein TusA family
IS495_RS14435	COG5562	phage envelope protein
IS495_RS14440	COG0401	homolog of Blt101
IS495_RS14445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS495_RS14450	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS14460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS495_RS14465	COG0477	Major facilitator Superfamily
IS495_RS14470	COG1113	amino acid transport
IS495_RS14475	COG2988	succinylglutamate desuccinylase activity
IS495_RS14480	COG3724	N-succinylarginine dihydrolase activity
IS495_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS14490	COG3138	arginine N-succinyltransferase
IS495_RS14495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS495_RS14505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS495_RS14510	COG0667	Aldo Keto reductase
IS495_RS14515	COG0583	DNA-binding transcription factor activity
IS495_RS14540	COG4122	O-methyltransferase activity
IS495_RS14545	COG1643	Atp-dependent helicase
IS495_RS14560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS495_RS14565	COG3327	negative regulation of DNA-templated transcription, initiation
IS495_RS14570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IS495_RS14575	COG0183	Belongs to the thiolase family
IS495_RS14580	COG2050	protein possibly involved in aromatic compounds catabolism
IS495_RS14585	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS495_RS14590	COG1024	Enoyl-CoA hydratase
IS495_RS14595	COG1024	Enoyl-CoA hydratase
IS495_RS14600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS495_RS14605	COG2151	metal-sulfur cluster biosynthetic enzyme
IS495_RS14610	COG3396	Phenylacetate-CoA oxygenase
IS495_RS14615	COG3460	Phenylacetate-CoA oxygenase
IS495_RS14620	COG3396	Phenylacetate-CoA oxygenase
IS495_RS14625	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS14625	COG2030	dehydratase
IS495_RS14645	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS14650	COG2207	Transcriptional regulator
IS495_RS14655	COG3784	Protein of unknown function (DUF1318)
IS495_RS14665	COG2911	Protein conserved in bacteria
IS495_RS14670	COG0586	Pfam SNARE associated Golgi protein
IS495_RS14675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS495_RS14680	COG3187	Heat shock protein
IS495_RS14685	COG3042	response to heat
IS495_RS14690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IS495_RS14690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IS495_RS14690	COG1013	pyruvate-flavodoxin oxidoreductase activity
IS495_RS14690	COG0674	pyruvate-flavodoxin oxidoreductase activity
IS495_RS14695	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS495_RS14705	COG0589	response to stress
IS495_RS14715	COG0513	Belongs to the DEAD box helicase family
IS495_RS14725	COG1349	DNA-binding transcription factor activity
IS495_RS14730	COG0673	inositol 2-dehydrogenase activity
IS495_RS14745	COG1113	amino acid transport
IS495_RS14750	COG1522	sequence-specific DNA binding
IS495_RS14760	COG1448	Aminotransferase
IS495_RS14765	COG2011	ABC-type metal ion transport system permease component
IS495_RS14780	COG0436	Aminotransferase
IS495_RS14785	COG0604	alcohol dehydrogenase
IS495_RS14815	COG0583	DNA-binding transcription factor activity
IS495_RS14835	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS14840	COG1309	transcriptional regulator
IS495_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS14940	COG2885	chlorophyll binding
IS495_RS14980	COG3344	reverse transcriptase
IS495_RS15025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IS495_RS15140	COG4171	peptide transport system, permease
IS495_RS15155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS495_RS15165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS495_RS15170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS495_RS15170	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS495_RS15185	COG1349	DNA-binding transcription factor activity
IS495_RS15195	COG0023	Translation Initiation Factor
IS495_RS15205	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IS495_RS15210	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IS495_RS15215	COG0671	phosphoesterase, PA-phosphatase related
IS495_RS15225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IS495_RS15250	COG0616	signal peptide processing
IS495_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS15265	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IS495_RS15275	COG0583	DNA-binding transcription factor activity
IS495_RS15285	COG0009	L-threonylcarbamoyladenylate synthase
IS495_RS15295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IS495_RS15300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS495_RS15300	COG0512	Glutamine amidotransferase of anthranilate synthase
IS495_RS15305	COG0134	indole-3-glycerol-phosphate synthase activity
IS495_RS15305	COG0135	phosphoribosylanthranilate isomerase activity
IS495_RS15360	COG4774	siderophore transport
IS495_RS15370	COG3047	cAMP biosynthetic process
IS495_RS15375	COG0727	PFAM Uncharacterised protein family (UPF0153)
IS495_RS15405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS495_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS15415	COG1988	membrane-bound metal-dependent
IS495_RS15420	COG1823	symporter activity
IS495_RS15430	COG0753	catalase activity
IS495_RS15440	COG1486	melibiose metabolic process
IS495_RS15445	COG2169	Transcriptional regulator
IS495_RS15445	COG1917	Cupin 2, conserved barrel domain protein
IS495_RS15450	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS495_RS15455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS15465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS15470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS495_RS15480	COG0322	excinuclease ABC activity
IS495_RS15485	COG3678	ATP-independent chaperone mediated protein folding
IS495_RS15495	COG3724	N-succinylarginine dihydrolase activity
IS495_RS15505	COG3138	arginine N-succinyltransferase
IS495_RS15515	COG0708	Exodeoxyribonuclease III
IS495_RS15520	COG0398	Pfam SNARE associated Golgi protein
IS495_RS15525	COG0398	Pfam SNARE associated Golgi protein
IS495_RS15530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS495_RS15535	COG4134	Bacterial extracellular solute-binding protein
IS495_RS15540	COG4135	transport system, permease component
IS495_RS15545	COG4136	ATPase activity
IS495_RS15550	COG2897	thiosulfate sulfurtransferase activity
IS495_RS15555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS495_RS15560	COG0494	nUDIX hydrolase
IS495_RS15565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IS495_RS15570	COG0604	alcohol dehydrogenase
IS495_RS15570	COG3321	synthase
IS495_RS15570	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS15575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS495_RS15580	COG0709	Synthesizes selenophosphate from selenide and ATP
IS495_RS15595	COG0778	Nitroreductase
IS495_RS15600	COG0616	signal peptide processing
IS495_RS15605	COG0252	asparaginase activity
IS495_RS15610	COG1335	isochorismatase
IS495_RS15615	COG2814	Major facilitator Superfamily
IS495_RS15620	COG1349	DNA-binding transcription factor activity
IS495_RS15625	COG0667	Aldo Keto reductase
IS495_RS15630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS15635	COG0191	fructose-bisphosphate aldolase activity
IS495_RS15640	COG1063	alcohol dehydrogenase
IS495_RS15645	COG2271	Major facilitator Superfamily
IS495_RS15650	COG1063	alcohol dehydrogenase
IS495_RS15665	COG3139	Protein of unknown function (DUF1315)
IS495_RS15690	COG3713	MltA-interacting MipA family protein
IS495_RS15695	COG2766	serine protein kinase
IS495_RS15710	COG0386	Belongs to the glutathione peroxidase family
IS495_RS15735	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS15740	COG0583	DNA-binding transcription factor activity
IS495_RS15745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS495_RS15750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS495_RS15755	COG3344	reverse transcriptase
IS495_RS15765	COG0859	PFAM glycosyl transferase family 9
IS495_RS15770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS495_RS15780	COG2207	Transcriptional regulator
IS495_RS15785	COG2807	transmembrane transport
IS495_RS15790	COG0504	CTP synthase activity
IS495_RS15795	COG1683	Conserved Protein
IS495_RS15800	COG3189	MarR family transcriptional regulator
IS495_RS15805	COG3042	response to heat
IS495_RS15810	COG2199	diguanylate cyclase activity
IS495_RS15810	COG2203	Gaf domain
IS495_RS15830	COG3182	Iron-regulated membrane protein
IS495_RS15840	COG1560	Kdo2-lipid A biosynthetic process
IS495_RS15850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IS495_RS15855	COG3706	GGDEF domain
IS495_RS15860	COG0583	DNA-binding transcription factor activity
IS495_RS15865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS495_RS15895	COG1294	oxidase, subunit
IS495_RS15900	COG1271	oxidase subunit
IS495_RS15905	COG3546	catalase activity
IS495_RS15910	COG3685	Protein conserved in bacteria
IS495_RS15915	COG3685	Protein conserved in bacteria
IS495_RS15920	COG3729	General stress protein
IS495_RS15930	COG1063	alcohol dehydrogenase
IS495_RS15935	COG3813	Protein conserved in bacteria
IS495_RS15955	COG0640	Transcriptional regulator
IS495_RS15960	COG0538	isocitrate dehydrogenase activity
IS495_RS16045	COG0616	signal peptide processing
IS495_RS16060	COG1802	Transcriptional regulator
IS495_RS16060	COG4626	Terminase
IS495_RS16105	COG3772	lysozyme
IS495_RS16130	COG1403	HNH endonuclease
IS495_RS16150	COG3344	reverse transcriptase
IS495_RS16200	COG1196	nuclear chromosome segregation
IS495_RS16240	COG0740	serine-type endopeptidase activity
IS495_RS16315	COG1403	HNH endonuclease
IS495_RS16320	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IS495_RS16350	COG1396	sequence-specific DNA binding
IS495_RS16405	COG0582	viral genome integration into host DNA
IS495_RS16410	COG0538	isocitrate dehydrogenase activity
IS495_RS16415	COG1187	pseudouridine synthase activity
IS495_RS16435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IS495_RS16455	COG2205	protein histidine kinase activity
IS495_RS16460	COG2850	peptidyl-arginine hydroxylation
IS495_RS16480	COG1177	transmembrane transport
IS495_RS16495	COG0318	PFAM AMP-dependent synthetase and ligase
IS495_RS16505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IS495_RS16515	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS495_RS16525	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS495_RS16535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IS495_RS16540	COG1376	ErfK ybiS ycfS ynhG family protein
IS495_RS16540	COG1388	LysM domain
IS495_RS16555	COG1309	transcriptional regulator
IS495_RS16570	COG3134	Outer membrane lipoprotein
IS495_RS16575	COG1252	NADH dehydrogenase
IS495_RS16600	COG5633	Lipoprotein
IS495_RS16605	COG0537	adenosine 5'-monophosphoramidase activity
IS495_RS16615	COG0084	hydrolase, TatD family'
IS495_RS16620	COG0470	DNA polymerase III
IS495_RS16630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IS495_RS16635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS495_RS16640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS495_RS16655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS495_RS16675	COG1399	metal-binding, possibly nucleic acid-binding protein
IS495_RS16695	COG1530	ribonuclease E activity
IS495_RS16700	COG0583	DNA-binding transcription factor activity
IS495_RS16705	COG2814	Major facilitator Superfamily
IS495_RS16725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS495_RS16770	COG1560	Kdo2-lipid A biosynthetic process
IS495_RS16785	COG5645	(Lipo)protein
IS495_RS16820	COG3381	protein complex oligomerization
IS495_RS16850	COG0583	DNA-binding transcription factor activity
IS495_RS16860	COG1335	isochorismatase
IS495_RS16870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS495_RS16875	COG1702	phosphate starvation-inducible protein PhoH
IS495_RS16895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS495_RS16905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS495_RS16920	COG1309	transcriptional regulator
IS495_RS16955	COG2233	PERMEase
IS495_RS16965	COG3729	General stress protein
IS495_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS17010	COG0531	amino acid
IS495_RS17015	COG0174	glutamine synthetase
IS495_RS17020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IS495_RS17025	COG1917	Cupin 2, conserved barrel domain protein
IS495_RS17025	COG1396	sequence-specific DNA binding
IS495_RS17030	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS17035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS495_RS17040	COG0583	DNA-binding transcription factor activity
IS495_RS17045	COG0473	3-isopropylmalate dehydrogenase activity
IS495_RS17050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS495_RS17055	COG4638	Rieske (2fe-2S)
IS495_RS17060	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS17065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS495_RS17090	COG0670	Belongs to the BI1 family
IS495_RS17105	COG2207	Transcriptional regulator
IS495_RS17110	COG1881	PFAM PEBP family protein
IS495_RS17125	COG1832	CoA-binding protein
IS495_RS17135	COG0210	DNA helicase
IS495_RS17140	COG3304	Inner membrane component domain
IS495_RS17145	COG1289	transmembrane transporter activity
IS495_RS17150	COG3070	regulator of competence-specific genes
IS495_RS17170	COG1067	ATP-dependent peptidase activity
IS495_RS17180	COG3130	regulation of translation
IS495_RS17185	COG3009	Protein conserved in bacteria
IS495_RS17190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS495_RS17190	COG3008	intermembrane lipid transfer
IS495_RS17195	COG2995	paraquat-inducible protein a
IS495_RS17200	COG0488	(ABC) transporter
IS495_RS17210	COG3217	Mosc domain protein beta barrel domain protein
IS495_RS17210	COG0633	Ferredoxin
IS495_RS17225	COG0431	NADPH-dependent FMN reductase
IS495_RS17230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS495_RS17235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS495_RS17240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS495_RS17250	COG0308	aminopeptidase N
IS495_RS17260	COG1473	amidohydrolase
IS495_RS17270	COG0814	amino acid
IS495_RS17295	COG1448	Aminotransferase
IS495_RS17300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS495_RS17305	COG3108	Peptidase M15
IS495_RS17310	COG2989	Protein conserved in bacteria
IS495_RS17320	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IS495_RS17330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS495_RS17335	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS495_RS17340	COG3173	Aminoglycoside phosphotransferase
IS495_RS17355	COG3214	Protein conserved in bacteria
IS495_RS17370	COG0658	competence protein
IS495_RS17370	COG2333	competence protein COMEC
IS495_RS17380	COG0539	negative regulation of cytoplasmic translation
IS495_RS17400	COG2323	membrane
IS495_RS17405	COG1944	ATP diphosphatase activity
IS495_RS17410	COG2116	formate transmembrane transporter activity
IS495_RS17415	COG1882	Formate acetyltransferase
IS495_RS17420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS495_RS17425	COG0477	Major facilitator Superfamily
IS495_RS17430	COG3302	dmso reductase anchor subunit
IS495_RS17435	COG0437	4 iron, 4 sulfur cluster binding
IS495_RS17440	COG0243	molybdopterin cofactor binding
IS495_RS17450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IS495_RS17460	COG1674	ftsk spoiiie
IS495_RS17460	COG1178	ABC-type Fe3 transport system permease component
IS495_RS17470	COG0492	ferredoxin-NADP+ reductase activity
IS495_RS17475	COG4988	ABC transporter
IS495_RS17480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IS495_RS17495	COG0542	response to heat
IS495_RS17505	COG1278	Cold shock
IS495_RS17515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS17520	COG3593	DNA synthesis involved in DNA repair
IS495_RS17530	COG2431	L-lysine efflux transmembrane transporter activity
IS495_RS17540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS495_RS17550	COG0028	Belongs to the TPP enzyme family
IS495_RS17555	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IS495_RS17560	COG0702	epimerase
IS495_RS17565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IS495_RS17570	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS495_RS17575	COG2203	Gaf domain
IS495_RS17575	COG4251	negative regulation of phosphorylation
IS495_RS17575	COG5001	Diguanylate cyclase
IS495_RS17575	COG3706	GGDEF domain
IS495_RS17585	COG1126	abc transporter atp-binding protein
IS495_RS17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS17595	COG4215	(ABC) transporter
IS495_RS17600	COG4160	amino acid transport
IS495_RS17605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS17610	COG5002	protein histidine kinase activity
IS495_RS17615	COG0745	RESPONSE REGULATOR receiver
IS495_RS17630	COG1177	transmembrane transport
IS495_RS17635	COG1176	ABC-type spermidine putrescine transport system, permease component I
IS495_RS17640	COG3842	ATPase activity
IS495_RS17645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS495_RS17840	COG4695	Portal protein
IS495_RS17875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS495_RS17915	COG3344	reverse transcriptase
IS495_RS17920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS495_RS17925	COG3226	Transcriptional regulator
IS495_RS17930	COG0738	Major facilitator superfamily
IS495_RS17935	COG0561	phosphatase activity
IS495_RS17940	COG2814	Major facilitator Superfamily
IS495_RS17945	COG0671	phosphoesterase, PA-phosphatase related
IS495_RS17950	COG1349	DNA-binding transcription factor activity
IS495_RS17955	COG1686	Belongs to the peptidase S11 family
IS495_RS17965	COG0625	glutathione transferase activity
IS495_RS17970	COG2133	pyrroloquinoline quinone binding
IS495_RS17980	COG2223	nitrite transmembrane transporter activity
IS495_RS18000	COG0747	negative chemotaxis
IS495_RS18015	COG0303	'Molybdopterin
IS495_RS18020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS495_RS18025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS495_RS18030	COG1882	Formate acetyltransferase
IS495_RS18035	COG0561	phosphatase activity
IS495_RS18045	COG1609	Transcriptional regulator
IS495_RS18050	COG2271	Major facilitator Superfamily
IS495_RS18060	COG0488	(ABC) transporter
IS495_RS18065	COG2365	Tyrosine phosphatase family
IS495_RS18070	COG1376	ErfK ybiS ycfS ynhG family protein
IS495_RS18075	COG2188	Transcriptional regulator
IS495_RS18080	COG2723	6-phospho-beta-galactosidase activity
IS495_RS18085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS495_RS18090	COG1321	iron dependent repressor
IS495_RS18100	COG2194	sulfuric ester hydrolase activity
IS495_RS18105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IS495_RS18120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS18125	COG0765	amino acid transport
IS495_RS18130	COG1126	abc transporter atp-binding protein
IS495_RS18135	COG0668	transmembrane transport
IS495_RS18145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS495_RS18155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IS495_RS18165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS495_RS18170	COG1199	ATP-dependent helicase activity
IS495_RS18175	COG0513	Belongs to the DEAD box helicase family
IS495_RS18180	COG3958	Transketolase
IS495_RS18185	COG3959	Transketolase, thiamine diphosphate binding domain
IS495_RS18190	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS18195	COG2271	Major facilitator Superfamily
IS495_RS18205	COG0583	DNA-binding transcription factor activity
IS495_RS18210	COG1309	transcriptional regulator
IS495_RS18215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS18220	COG1131	(ABC) transporter
IS495_RS18225	COG0842	Transport permease protein
IS495_RS18230	COG0842	Transport permease protein
IS495_RS18240	COG3568	Endonuclease Exonuclease Phosphatase
IS495_RS18245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS495_RS18250	COG0392	lysyltransferase activity
IS495_RS18255	COG0670	Belongs to the BI1 family
IS495_RS18260	COG0314	molybdopterin synthase activity
IS495_RS18265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IS495_RS18275	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS495_RS18295	COG0745	RESPONSE REGULATOR receiver
IS495_RS18300	COG0642	Histidine kinase
IS495_RS18325	COG2226	methyltransferase
IS495_RS18340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS495_RS18345	COG1881	PFAM PEBP family protein
IS495_RS18385	COG4677	pectinesterase activity
IS495_RS18420	COG0789	Transcriptional regulator
IS495_RS18425	COG2200	EAL domain
IS495_RS18450	COG0561	phosphatase activity
IS495_RS18455	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IS495_RS18460	COG4149	molybdate abc transporter
IS495_RS18465	COG0725	ABC transporter, periplasmic molybdate-binding protein
IS495_RS18475	COG3585	molybdate ion transport
IS495_RS18475	COG2005	Transcriptional regulator
IS495_RS18480	COG1119	ATPase activity
IS495_RS18490	COG1085	galactose-1-phosphate uridylyltransferase
IS495_RS18500	COG2017	converts alpha-aldose to the beta-anomer
IS495_RS18510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS495_RS18525	COG3201	nicotinamide mononucleotide transporter
IS495_RS18530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IS495_RS18570	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IS495_RS18575	COG2885	chlorophyll binding
IS495_RS18585	COG3064	Membrane
IS495_RS18590	COG0848	biopolymer transport protein
IS495_RS18595	COG0811	peptide transport
IS495_RS18600	COG0824	Thioesterase
IS495_RS18605	COG3790	cyd operon protein YbgE
IS495_RS18610	COG4890	Cyd operon protein YbgT
IS495_RS18615	COG1294	oxidase, subunit
IS495_RS18620	COG1271	oxidase subunit
IS495_RS18625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IS495_RS18635	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS495_RS18640	COG0567	Dehydrogenase, E1 component
IS495_RS18645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS495_RS18650	COG1053	succinate dehydrogenase
IS495_RS18655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IS495_RS18660	COG2009	succinate dehydrogenase
IS495_RS18695	COG1984	allophanate hydrolase subunit 2
IS495_RS18700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IS495_RS18715	COG0415	Belongs to the DNA photolyase family
IS495_RS18745	COG2205	protein histidine kinase activity
IS495_RS18750	COG0745	RESPONSE REGULATOR receiver
IS495_RS18760	COG0033	Phosphoglucomutase
IS495_RS18770	COG0596	Alpha beta hydrolase
IS495_RS18785	COG0735	belongs to the Fur family
IS495_RS18825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IS495_RS18830	COG1846	Transcriptional regulator
IS495_RS18830	COG1940	carbohydrate kinase activity
IS495_RS18835	COG0647	UMP catabolic process
IS495_RS18840	COG0367	asparagine synthase
IS495_RS18880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS495_RS18890	COG1702	phosphate starvation-inducible protein PhoH
IS495_RS18900	COG4535	Mg2 and Co2 transporter CorC
IS495_RS18915	COG0765	amino acid transport
IS495_RS18920	COG0765	amino acid transport
IS495_RS18925	COG1126	abc transporter atp-binding protein
IS495_RS18940	COG2888	peptidyl-tyrosine sulfation
IS495_RS18955	COG1466	dna polymerase III delta subunit
IS495_RS18970	COG0799	negative regulation of ribosome biogenesis
IS495_RS18980	COG0768	penicillin binding
IS495_RS18985	COG0772	Belongs to the SEDS family
IS495_RS18990	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS495_RS18995	COG1686	Belongs to the peptidase S11 family
IS495_RS19010	COG0583	DNA-binding transcription factor activity
IS495_RS19025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS495_RS19045	COG3069	C4-dicarboxylate transmembrane transporter activity
IS495_RS19050	COG3719	Belongs to the RNase T2 family
IS495_RS19055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS495_RS19075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS495_RS19080	COG0583	DNA-binding transcription factor activity
IS495_RS19085	COG3969	phosphoadenosine phosphosulfate
IS495_RS19090	COG1475	DNA binding
IS495_RS19095	COG0436	Aminotransferase
IS495_RS19120	COG1129	ABC transporter
IS495_RS19125	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS19130	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS19140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS495_RS19155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS495_RS19165	COG0402	S-adenosylhomocysteine deaminase activity
IS495_RS19175	COG0483	inositol monophosphate 1-phosphatase activity
IS495_RS19180	COG2271	Major facilitator Superfamily
IS495_RS19210	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS19215	COG1129	ABC transporter
IS495_RS19220	COG0371	Dehydrogenase
IS495_RS19225	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS19240	COG2879	small protein
IS495_RS19245	COG1966	Carbon starvation protein
IS495_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS19260	COG1535	isochorismatase
IS495_RS19260	COG3433	isochorismatase activity
IS495_RS19265	COG1021	2,3-dihydroxybenzoate-AMP ligase
IS495_RS19270	COG1169	isochorismate synthase
IS495_RS19275	COG4592	Periplasmic binding protein
IS495_RS19285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS19290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS19295	COG1120	ATPase activity
IS495_RS19300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS495_RS19300	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IS495_RS19305	COG3251	PFAM MbtH domain protein
IS495_RS19310	COG2382	esterase
IS495_RS19315	COG4771	TonB-dependent receptor
IS495_RS19320	COG2977	Belongs to the P-Pant transferase superfamily
IS495_RS19325	COG3958	Transketolase
IS495_RS19330	COG3959	Transketolase, thiamine diphosphate binding domain
IS495_RS19335	COG2390	Transcriptional regulator
IS495_RS19340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS495_RS19345	COG1879	ABC-type sugar transport system periplasmic component
IS495_RS19355	COG1129	ABC transporter
IS495_RS19360	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS19370	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS19380	COG0583	DNA-binding transcription factor activity
IS495_RS19385	COG0668	transmembrane transport
IS495_RS19395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS495_RS19420	COG0747	negative chemotaxis
IS495_RS19425	COG0601	transmembrane transport
IS495_RS19430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS495_RS19435	COG0444	Belongs to the ABC transporter superfamily
IS495_RS19440	COG4608	Belongs to the ABC transporter superfamily
IS495_RS19445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS495_RS19450	COG4221	oxidoreductase activity
IS495_RS19460	COG4215	(ABC) transporter
IS495_RS19465	COG0765	amino acid transport
IS495_RS19470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IS495_RS19485	COG0697	spore germination
IS495_RS19495	COG3698	Phosphodiester glycosidase
IS495_RS19540	COG2315	Protein conserved in bacteria
IS495_RS19545	COG0778	Nitroreductase
IS495_RS19555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS19565	COG3716	PTS system mannose fructose sorbose family IID component
IS495_RS19570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS495_RS19575	COG2222	sugar isomerase
IS495_RS19580	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS495_RS19580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS495_RS19595	COG0477	Major facilitator Superfamily
IS495_RS19600	COG0668	transmembrane transport
IS495_RS19630	COG3188	usher protein
IS495_RS19645	COG2771	luxR family
IS495_RS19655	COG0673	inositol 2-dehydrogenase activity
IS495_RS19665	COG2211	Major facilitator Superfamily
IS495_RS19670	COG1113	amino acid transport
IS495_RS19685	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS19690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS495_RS19700	COG0531	amino acid
IS495_RS19745	COG0667	Aldo Keto reductase
IS495_RS19750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS19755	COG1473	amidohydrolase
IS495_RS19785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS19790	COG1120	ATPase activity
IS495_RS19795	COG1566	PFAM secretion protein HlyD family protein
IS495_RS19840	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS19845	COG1129	ABC transporter
IS495_RS19860	COG0673	inositol 2-dehydrogenase activity
IS495_RS19890	COG3104	oligopeptide transport
IS495_RS19895	COG1982	Orn Lys Arg decarboxylase major
IS495_RS19900	COG0531	amino acid
IS495_RS19905	COG3710	Transcriptional regulator
IS495_RS19915	COG1560	Kdo2-lipid A biosynthetic process
IS495_RS19930	COG3188	usher protein
IS495_RS19935	COG3121	Chaperone
IS495_RS19940	COG3539	Fimbrial protein
IS495_RS19990	COG2501	S4 domain
IS495_RS20000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS495_RS20015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IS495_RS20020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IS495_RS20040	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IS495_RS20045	COG4181	ATPase activity
IS495_RS20050	COG2755	lipolytic protein G-D-S-L family
IS495_RS20055	COG0300	oxidoreductase activity
IS495_RS20060	COG3118	belongs to the thioredoxin family
IS495_RS20065	COG0390	transport system, permease component
IS495_RS20070	COG4619	ABC transporter
IS495_RS20075	COG0330	HflC and HflK could
IS495_RS20080	COG1585	Membrane protein implicated in regulation of membrane protease activity
IS495_RS20095	COG3735	TraB family
IS495_RS20100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS495_RS20110	COG2223	nitrite transmembrane transporter activity
IS495_RS20115	COG4651	solute:proton antiporter activity
IS495_RS20115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS495_RS20120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS20160	COG2832	Protein of unknown function (DUF454)
IS495_RS20165	COG3923	Primosomal replication protein n
IS495_RS20175	COG5464	transposase or invertase
IS495_RS20180	COG1196	nuclear chromosome segregation
IS495_RS20180	COG3264	Mechanosensitive ion channel
IS495_RS20200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS20205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS495_RS20220	COG0110	maltose O-acetyltransferase activity
IS495_RS20270	COG1874	Beta-galactosidase
IS495_RS20275	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IS495_RS20280	COG3833	ABC-type maltose transport systems, permease component
IS495_RS20285	COG1175	transmembrane transport
IS495_RS20290	COG2182	Extracellular solute-binding protein
IS495_RS20300	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS495_RS20315	COG2364	Membrane
IS495_RS20345	COG3695	enzyme binding
IS495_RS20350	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IS495_RS20355	COG1946	Acyl-CoA thioesterase
IS495_RS20360	COG0004	ammonium transporteR
IS495_RS20365	COG0347	Belongs to the P(II) protein family
IS495_RS20370	COG1132	(ABC) transporter
IS495_RS20375	COG1132	(ABC) transporter
IS495_RS20380	COG1522	sequence-specific DNA binding
IS495_RS20395	COG4533	DNA binding
IS495_RS20405	COG0824	Thioesterase
IS495_RS20410	COG1555	photosystem II stabilization
IS495_RS20415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS495_RS20420	COG0776	regulation of translation
IS495_RS20425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IS495_RS20445	COG0271	Belongs to the BolA IbaG family
IS495_RS20450	COG3056	Lipoprotein
IS495_RS20455	COG2223	nitrite transmembrane transporter activity
IS495_RS20460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS495_RS20465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS495_RS20470	COG1845	cytochrome c oxidase, subunit III
IS495_RS20475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IS495_RS20490	COG1414	Transcriptional regulator
IS495_RS20495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS495_RS20500	COG1053	succinate dehydrogenase
IS495_RS20510	COG1053	succinate dehydrogenase
IS495_RS20525	COG0673	inositol 2-dehydrogenase activity
IS495_RS20530	COG2814	Major facilitator Superfamily
IS495_RS20540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IS495_RS20545	COG0693	protein deglycase activity
IS495_RS20565	COG0142	geranyltranstransferase activity
IS495_RS20575	COG0667	Aldo Keto reductase
IS495_RS20580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IS495_RS20600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS495_RS20600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS495_RS20610	COG4238	major outer membrane lipoprotein
IS495_RS20630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS495_RS20635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS495_RS20640	COG1862	Preprotein translocase
IS495_RS20665	COG0450	alkyl hydroperoxide reductase
IS495_RS20675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS20690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS20700	COG1228	amidohydrolase
IS495_RS20710	COG1335	isochorismatase
IS495_RS20715	COG0583	DNA-binding transcription factor activity
IS495_RS20720	COG0366	Alpha amylase catalytic
IS495_RS20745	COG0420	3'-5' exonuclease activity
IS495_RS20750	COG0419	ATPase involved in DNA repair
IS495_RS20755	COG1940	carbohydrate kinase activity
IS495_RS20770	COG4126	flavin adenine dinucleotide binding
IS495_RS20780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IS495_RS20785	COG3416	Protein conserved in bacteria
IS495_RS20795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IS495_RS20805	COG1785	Belongs to the alkaline phosphatase family
IS495_RS20845	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IS495_RS20850	COG1335	isochorismatase
IS495_RS20855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IS495_RS20860	COG0113	porphobilinogen synthase activity
IS495_RS20870	COG2175	clavaminate synthase activity
IS495_RS20875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS495_RS20880	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IS495_RS20885	COG4521	taurine ABC transporter
IS495_RS20890	COG2040	homocysteine
IS495_RS20895	COG0833	amino acid
IS495_RS20910	COG4303	Ethanolamine ammonia lyase large subunit
IS495_RS20915	COG4302	ethanolamine ammonia-lyase activity
IS495_RS20955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS20960	COG1126	abc transporter atp-binding protein
IS495_RS20965	COG0765	amino acid transport
IS495_RS20970	COG0765	amino acid transport
IS495_RS20985	COG3188	usher protein
IS495_RS21010	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IS495_RS21020	COG3639	organic phosphonate transmembrane transporter activity
IS495_RS21040	COG0791	NLP P60 protein
IS495_RS21065	COG0582	viral genome integration into host DNA
IS495_RS21070	COG1192	Involved in chromosome partitioning
IS495_RS21130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IS495_RS21135	COG0022	dehydrogenase e1 component
IS495_RS21140	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS495_RS21145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS495_RS21165	COG1070	Carbohydrate kinase
IS495_RS21170	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS21175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS495_RS21180	COG3775	system Galactitol-specific IIC component
IS495_RS21185	COG0625	glutathione transferase activity
IS495_RS21190	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IS495_RS21205	COG0579	oxidoreductase
IS495_RS21210	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS21215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS495_RS21220	COG1113	amino acid transport
IS495_RS21225	COG1802	Transcriptional regulator
IS495_RS21245	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS495_RS21250	COG0454	-acetyltransferase
IS495_RS21265	COG2991	Protein conserved in bacteria
IS495_RS21280	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS495_RS21285	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS495_RS21300	COG3034	peptidoglycan biosynthetic process
IS495_RS21305	COG0121	glutamine amidotransferase
IS495_RS21315	COG1960	acyl-CoA dehydrogenase activity
IS495_RS21320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS495_RS21330	COG0583	DNA-binding transcription factor activity
IS495_RS21340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS495_RS21350	COG2226	methyltransferase
IS495_RS21360	COG1388	LysM domain
IS495_RS21360	COG0741	lytic transglycosylase activity
IS495_RS21365	COG2226	methyltransferase
IS495_RS21375	COG2814	Major facilitator Superfamily
IS495_RS21380	COG0583	DNA-binding transcription factor activity
IS495_RS21385	COG0656	L-ascorbic acid biosynthetic process
IS495_RS21420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS495_RS21430	COG2011	ABC-type metal ion transport system permease component
IS495_RS21435	COG1464	Belongs to the NlpA lipoprotein family
IS495_RS21445	COG1720	tRNA m6t6A37 methyltransferase activity
IS495_RS21455	COG0791	NLP P60 protein
IS495_RS21460	COG3015	lipoprotein NlpE involved in copper resistance
IS495_RS21465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IS495_RS21480	COG4568	rho-dependent transcription termination
IS495_RS21490	COG0346	lactoylglutathione lyase activity
IS495_RS21495	COG1982	Orn Lys Arg decarboxylase major
IS495_RS21535	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IS495_RS21545	COG0750	zinc metalloprotease
IS495_RS21550	COG0575	Belongs to the CDS family
IS495_RS21560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IS495_RS21585	COG0024	Methionine aminopeptidase
IS495_RS21590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IS495_RS21605	COG3835	regulator
IS495_RS21610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS495_RS21630	COG2860	membrane
IS495_RS21650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS21655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS495_RS21660	COG1120	ATPase activity
IS495_RS21670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS495_RS21765	COG1643	Atp-dependent helicase
IS495_RS21770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IS495_RS21790	COG0617	tRNA 3'-terminal CCA addition
IS495_RS21795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS495_RS21815	COG0726	polysaccharide deacetylase
IS495_RS21820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS21825	COG0842	Transport permease protein
IS495_RS21830	COG1131	(ABC) transporter
IS495_RS21835	COG0288	reversible hydration of carbon dioxide
IS495_RS21850	COG4993	Dehydrogenase
IS495_RS21855	COG2132	Multicopper oxidase
IS495_RS21905	COG3064	Membrane
IS495_RS21920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS495_RS21925	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS495_RS21930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IS495_RS21935	COG2186	Transcriptional regulator
IS495_RS21940	COG1113	amino acid transport
IS495_RS21945	COG2211	Major facilitator Superfamily
IS495_RS21950	COG3940	Belongs to the glycosyl hydrolase 43 family
IS495_RS21955	COG3725	Membrane protein required for beta-lactamase induction
IS495_RS21960	COG3023	N-Acetylmuramoyl-L-alanine amidase
IS495_RS21970	COG4969	Belongs to the N-Me-Phe pilin family
IS495_RS21975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS495_RS21980	COG1459	type II secretion system
IS495_RS22005	COG0494	nUDIX hydrolase
IS495_RS22025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IS495_RS22030	COG0849	cell division
IS495_RS22055	COG0772	Belongs to the SEDS family
IS495_RS22070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IS495_RS22075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IS495_RS22080	COG0768	penicillin binding
IS495_RS22100	COG1609	Transcriptional regulator
IS495_RS22110	COG0028	Belongs to the TPP enzyme family
IS495_RS22155	COG0738	Major facilitator superfamily
IS495_RS22165	COG0583	DNA-binding transcription factor activity
IS495_RS22170	COG2271	Major facilitator Superfamily
IS495_RS22175	COG2814	Major facilitator Superfamily
IS495_RS22195	COG1178	ABC-type Fe3 transport system permease component
IS495_RS22205	COG0586	Pfam SNARE associated Golgi protein
IS495_RS22225	COG0235	Class ii aldolase
IS495_RS22230	COG0417	DNA replication proofreading
IS495_RS22240	COG0564	pseudouridine synthase activity
IS495_RS22250	COG3493	citrate carrier protein
IS495_RS22265	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS495_RS22270	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IS495_RS22280	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS495_RS22325	COG0505	Belongs to the CarA family
IS495_RS22390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IS495_RS22415	COG1047	Peptidyl-prolyl cis-trans
IS495_RS22430	COG0196	riboflavin kinase activity
IS495_RS22440	COG0583	DNA-binding transcription factor activity
IS495_RS22465	COG4735	regulation of single-species biofilm formation
IS495_RS22470	COG1584	GPR1 FUN34 yaaH family protein
IS495_RS22475	COG0477	Major facilitator Superfamily
IS495_RS22480	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS495_RS22485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IS495_RS22490	COG1115	amino acid carrier protein
IS495_RS22505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IS495_RS22515	COG0527	aspartate kinase activity
IS495_RS22515	COG0460	homoserine dehydrogenase
IS495_RS22525	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IS495_RS22535	COG0745	RESPONSE REGULATOR receiver
IS495_RS22540	COG4452	Inner membrane protein CreD
IS495_RS22545	COG2205	protein histidine kinase activity
IS495_RS22550	COG0745	RESPONSE REGULATOR receiver
IS495_RS22555	COG3045	CreA protein
IS495_RS22560	COG3708	Transcriptional regulator
IS495_RS22560	COG2207	Transcriptional regulator
IS495_RS22580	COG0741	lytic transglycosylase activity
IS495_RS22585	COG0488	(ABC) transporter
IS495_RS22595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IS495_RS22600	COG0560	Phosphoserine phosphatase
IS495_RS22605	COG3726	membrane protein affecting hemolysin expression
IS495_RS22635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS495_RS22640	COG0084	hydrolase, TatD family'
IS495_RS22645	COG4667	esterase of the alpha-beta hydrolase superfamily
IS495_RS22655	COG2823	Periplasmic or secreted lipoprotein
IS495_RS22665	COG1011	Hydrolase
IS495_RS22670	COG0456	acetyltransferase
IS495_RS22675	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IS495_RS22710	COG3706	GGDEF domain
IS495_RS22715	COG4114	ferric iron reductase
IS495_RS22720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS22720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS22725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS495_RS22730	COG2197	response regulator
IS495_RS22735	COG2197	response regulator
IS495_RS22750	COG2966	Psort location CytoplasmicMembrane, score
IS495_RS22765	COG1484	DNA-dependent DNA replication
IS495_RS22780	COG5464	transposase or invertase
IS495_RS22790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS495_RS22795	COG3716	PTS system mannose fructose sorbose family IID component
IS495_RS22800	COG3715	PTS system
IS495_RS22815	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IS495_RS22815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS495_RS22825	COG1063	alcohol dehydrogenase
IS495_RS22830	COG1802	Transcriptional regulator
IS495_RS22835	COG2271	Major facilitator Superfamily
IS495_RS22840	COG0456	acetyltransferase
IS495_RS22840	COG1214	PFAM Peptidase M22, glycoprotease
IS495_RS22850	COG1737	Transcriptional regulator
IS495_RS22855	COG0800	Aldolase
IS495_RS22860	COG3734	2-keto-3-deoxy-galactonokinase
IS495_RS22875	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IS495_RS22905	COG1846	Transcriptional regulator
IS495_RS22915	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS495_RS22925	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS22930	COG3384	dioxygenase
IS495_RS22940	COG3971	2-oxopent-4-enoate hydratase activity
IS495_RS22960	COG2368	4-hydroxyphenylacetate
IS495_RS22965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS495_RS22980	COG1966	Carbon starvation protein
IS495_RS22985	COG2879	small protein
IS495_RS22990	COG0523	cobalamin synthesis protein
IS495_RS23000	COG1012	belongs to the aldehyde dehydrogenase family
IS495_RS23005	COG5464	transposase or invertase
IS495_RS23010	COG1917	Cupin 2, conserved barrel domain protein
IS495_RS23010	COG2207	Transcriptional regulator
IS495_RS23020	COG2733	membrane
IS495_RS23035	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IS495_RS23040	COG1924	4 iron, 4 sulfur cluster binding
IS495_RS23055	COG1566	PFAM secretion protein HlyD family protein
IS495_RS23065	COG5457	Domain of unknown function (DUF1127)
IS495_RS23070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS495_RS23080	COG0583	DNA-binding transcription factor activity
IS495_RS23085	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS495_RS23095	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS23100	COG1129	ABC transporter
IS495_RS23105	COG1879	ABC-type sugar transport system periplasmic component
IS495_RS23115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS23120	COG0842	Transport permease protein
IS495_RS23120	COG1129	ABC transporter
IS495_RS23125	COG0842	Transport permease protein
IS495_RS23155	COG2850	peptidyl-arginine hydroxylation
IS495_RS23170	COG5002	protein histidine kinase activity
IS495_RS23175	COG0745	RESPONSE REGULATOR receiver
IS495_RS23180	COG1538	Outer membrane efflux protein
IS495_RS23185	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS23190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS23195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS495_RS23205	COG3040	lipid binding
IS495_RS23210	COG0789	Transcriptional regulator
IS495_RS23220	COG0300	oxidoreductase activity
IS495_RS23235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS495_RS23255	COG3272	Protein of unknown function (DUF1722)
IS495_RS23260	COG4580	involved in the transport of maltose and maltodextrins
IS495_RS23270	COG2211	Major facilitator Superfamily
IS495_RS23275	COG3507	Belongs to the glycosyl hydrolase 43 family
IS495_RS23370	COG3039	Transposase
IS495_RS23380	COG0582	viral genome integration into host DNA
IS495_RS23390	COG0288	reversible hydration of carbon dioxide
IS495_RS23395	COG0659	secondary active sulfate transmembrane transporter activity
IS495_RS23400	COG1064	alcohol dehydrogenase
IS495_RS23405	COG1175	transmembrane transport
IS495_RS23410	COG0395	ABC-type sugar transport system, permease component
IS495_RS23415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS495_RS23420	COG3842	ATPase activity
IS495_RS23425	COG1653	transport
IS495_RS23435	COG1082	Xylose isomerase domain protein TIM barrel
IS495_RS23445	COG3962	Belongs to the TPP enzyme family
IS495_RS23450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS23455	COG0837	glucose binding
IS495_RS23455	COG1737	Transcriptional regulator
IS495_RS23460	COG3718	enzyme involved in inositol metabolism
IS495_RS23475	COG0433	COG0433 Predicted ATPase
IS495_RS23480	COG0795	lipopolysaccharide-transporting ATPase activity
IS495_RS23485	COG0795	lipopolysaccharide-transporting ATPase activity
IS495_RS23495	COG2927	DNA polymerase III (CHI subunit)
IS495_RS23500	COG0525	valine-tRNA ligase activity
IS495_RS23525	COG2188	Transcriptional regulator
IS495_RS23530	COG1288	antiporter activity
IS495_RS23535	COG1228	amidohydrolase
IS495_RS23540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS23545	COG2222	sugar isomerase
IS495_RS23550	COG2731	YhcH YjgK YiaL family protein
IS495_RS23585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS495_RS23585	COG1263	PTS System
IS495_RS23590	COG0366	Alpha amylase catalytic
IS495_RS23595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IS495_RS23600	COG1486	melibiose metabolic process
IS495_RS23625	COG0602	queuosine metabolic process
IS495_RS23630	COG2026	Addiction module toxin, RelE StbE family
IS495_RS23635	COG3077	Addiction module antitoxin, RelB DinJ family
IS495_RS23640	COG3711	transcriptional antiterminator
IS495_RS23640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS495_RS23645	COG2706	6-phosphogluconolactonase activity
IS495_RS23660	COG3964	amidohydrolase
IS495_RS23700	COG0312	modulator of DNA gyrase
IS495_RS23725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS495_RS23735	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS23740	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS23745	COG1129	ABC transporter
IS495_RS23750	COG1879	ABC-type sugar transport system periplasmic component
IS495_RS23770	COG2105	PFAM AIG2 family protein
IS495_RS23775	COG2911	Protein conserved in bacteria
IS495_RS23780	COG0729	surface antigen
IS495_RS23790	COG1253	flavin adenine dinucleotide binding
IS495_RS23805	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IS495_RS23820	COG1733	regulation of RNA biosynthetic process
IS495_RS23825	COG0702	epimerase
IS495_RS23835	COG0697	spore germination
IS495_RS23845	COG1113	amino acid transport
IS495_RS23850	COG0545	Peptidyl-prolyl cis-trans isomerase
IS495_RS23855	COG3061	Opacity-associated protein A
IS495_RS23865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IS495_RS23870	COG2965	DNA replication, synthesis of RNA primer
IS495_RS23930	COG1073	alpha beta
IS495_RS23935	COG3650	response to hydrogen peroxide
IS495_RS23945	COG1960	acyl-CoA dehydrogenase activity
IS495_RS23950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS495_RS23955	COG0557	exoribonuclease II activity
IS495_RS23970	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IS495_RS23980	COG0330	HflC and HflK could
IS495_RS23985	COG0330	HflC and HflK could
IS495_RS23990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS495_RS24010	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS495_RS24015	COG0802	atpase or kinase
IS495_RS24020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IS495_RS24020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IS495_RS24025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS495_RS24045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS495_RS24065	COG1511	domain protein
IS495_RS24065	COG3264	Mechanosensitive ion channel
IS495_RS24080	COG1053	succinate dehydrogenase
IS495_RS24085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS495_RS24105	COG2076	Multidrug Resistance protein
IS495_RS24110	COG5510	response to toxic substance
IS495_RS24125	COG1509	lysine 2,3-aminomutase activity
IS495_RS24200	COG0531	amino acid
IS495_RS24205	COG3030	protein affecting phage T7 exclusion by the F plasmid
IS495_RS24210	COG1027	Aspartate ammonia-lyase
IS495_RS24215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS495_RS24230	COG1309	transcriptional regulator
IS495_RS24260	COG0457	Tetratricopeptide repeat
IS495_RS24265	COG0726	polysaccharide deacetylase
IS495_RS24265	COG1649	PFAM Uncharacterised BCR, COG1649
IS495_RS24270	COG1215	transferase activity, transferring glycosyl groups
IS495_RS24285	COG0861	Integral membrane protein TerC family
IS495_RS24330	COG1486	melibiose metabolic process
IS495_RS24335	COG2169	Transcriptional regulator
IS495_RS24345	COG2824	Alkylphosphonate utilization operon protein PhnA
IS495_RS24350	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IS495_RS24355	COG2188	Transcriptional regulator
IS495_RS24360	COG3624	Phosphonate C-P lyase system protein PhnG
IS495_RS24365	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IS495_RS24370	COG3626	phosphonate metabolism
IS495_RS24375	COG3627	carbon phosphorus lyase activity
IS495_RS24380	COG4107	phosphonate C-P lyase system protein PhnK
IS495_RS24385	COG4778	phosphonate C-P lyase system protein PhnL
IS495_RS24390	COG3454	Phosphonate metabolism
IS495_RS24400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IS495_RS24410	COG0784	Response regulator, receiver
IS495_RS24410	COG4191	Histidine kinase
IS495_RS24415	COG1129	ABC transporter
IS495_RS24420	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS24455	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IS495_RS24460	COG1301	dicarboxylic acid transport
IS495_RS24470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS495_RS24475	COG3162	membrane
IS495_RS24505	COG3539	Fimbrial protein
IS495_RS24510	COG1346	cytolysis
IS495_RS24515	COG1380	Effector of murein hydrolase LrgA
IS495_RS24520	COG0583	DNA-binding transcription factor activity
IS495_RS24525	COG0025	NhaP-type Na H and K H
IS495_RS24530	COG2252	PERMEase
IS495_RS24535	COG0625	glutathione transferase activity
IS495_RS24540	COG0789	Transcriptional regulator
IS495_RS24550	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IS495_RS24580	COG1234	tRNA 3'-trailer cleavage
IS495_RS24585	COG1609	Transcriptional regulator
IS495_RS24590	COG0483	inositol monophosphate 1-phosphatase activity
IS495_RS24610	COG0741	lytic transglycosylase activity
IS495_RS24625	COG2315	Protein conserved in bacteria
IS495_RS24630	COG0432	Pfam Uncharacterised protein family UPF0047
IS495_RS24645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IS495_RS24650	COG0305	Participates in initiation and elongation during chromosome replication
IS495_RS24665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS495_RS24675	COG0735	belongs to the Fur family
IS495_RS24680	COG3237	CsbD-like
IS495_RS24690	COG0534	Mate efflux family protein
IS495_RS24700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IS495_RS24770	COG0251	oxidation-reduction process
IS495_RS24780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IS495_RS24790	COG0527	aspartate kinase activity
IS495_RS24845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS495_RS24875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IS495_RS24885	COG0456	acetyltransferase
IS495_RS24915	COG0151	Belongs to the GarS family
IS495_RS24925	COG4191	Histidine kinase
IS495_RS24930	COG3678	ATP-independent chaperone mediated protein folding
IS495_RS24965	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IS495_RS24980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS495_RS24985	COG2104	thiamine diphosphate biosynthetic process
IS495_RS25000	COG3706	GGDEF domain
IS495_RS25010	COG1447	Phosphotransferase system cellobiose-specific component IIA
IS495_RS25015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS495_RS25050	COG0250	Participates in transcription elongation, termination and antitermination
IS495_RS25095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IS495_RS25125	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IS495_RS25135	COG1739	Uncharacterized protein family UPF0029
IS495_RS25175	COG0805	protein transport
IS495_RS25195	COG3165	ubiquinone biosynthetic process from chorismate
IS495_RS25225	COG0583	DNA-binding transcription factor activity
IS495_RS25230	COG0697	spore germination
IS495_RS25235	COG0561	phosphatase activity
IS495_RS25240	COG2267	carboxylic ester hydrolase activity
IS495_RS25245	COG1280	lysine exporter protein (LysE YggA)
IS495_RS25255	COG1280	lysine exporter protein (LysE YggA)
IS495_RS25285	COG0210	DNA helicase
IS495_RS25290	COG1011	Hydrolase
IS495_RS25320	COG3072	Adenylate cyclase
IS495_RS25335	COG2959	enzyme of heme biosynthesis
IS495_RS25340	COG3071	HemY protein
IS495_RS25385	COG2244	polysaccharide biosynthetic process
IS495_RS25390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IS495_RS25395	COG0456	acetyltransferase
IS495_RS25400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IS495_RS25405	COG1088	dTDP-glucose 4,6-dehydratase activity
IS495_RS25410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IS495_RS25415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IS495_RS25425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS495_RS25430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IS495_RS25435	COG3118	belongs to the thioredoxin family
IS495_RS25460	COG1811	Na channel or pump
IS495_RS25470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS495_RS25475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS495_RS25485	COG0583	DNA-binding transcription factor activity
IS495_RS25490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IS495_RS25505	COG3978	acetolactate synthase activity
IS495_RS25525	COG3085	chromosome segregation
IS495_RS25600	COG0583	DNA-binding transcription factor activity
IS495_RS25615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IS495_RS25630	COG3443	Belongs to the bacterial solute-binding protein 9 family
IS495_RS25635	COG2207	Transcriptional regulator
IS495_RS25645	COG0371	Dehydrogenase
IS495_RS25650	COG0697	spore germination
IS495_RS25660	COG0583	DNA-binding transcription factor activity
IS495_RS25670	COG0737	Belongs to the 5'-nucleotidase family
IS495_RS25680	COG0527	aspartate kinase activity
IS495_RS25680	COG0460	homoserine dehydrogenase
IS495_RS25685	COG0626	cystathionine gamma-synthase activity
IS495_RS25700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IS495_RS25705	COG1609	Transcriptional regulator
IS495_RS25710	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS495_RS25725	COG1575	Belongs to the MenA family. Type 1 subfamily
IS495_RS25745	COG3678	ATP-independent chaperone mediated protein folding
IS495_RS25750	COG0745	RESPONSE REGULATOR receiver
IS495_RS25755	COG2205	protein histidine kinase activity
IS495_RS25760	COG2258	MOSC domain
IS495_RS25765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IS495_RS25805	COG1129	ABC transporter
IS495_RS25810	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS25815	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS25820	COG1454	alcohol dehydrogenase
IS495_RS25830	COG2211	Major facilitator Superfamily
IS495_RS25890	COG0205	6-phosphofructokinase activity
IS495_RS25910	COG0437	4 iron, 4 sulfur cluster binding
IS495_RS25915	COG2864	formate dehydrogenase
IS495_RS25930	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IS495_RS25935	COG0657	acetylesterase activity
IS495_RS25940	COG0456	acetyltransferase
IS495_RS25955	COG1011	Hydrolase
IS495_RS25970	COG3852	Histidine kinase
IS495_RS25985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS495_RS26005	COG0204	Acyl-transferase
IS495_RS26015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IS495_RS26020	COG3084	Protein conserved in bacteria
IS495_RS26030	COG1763	Mo-molybdopterin cofactor biosynthetic process
IS495_RS26055	COG2186	Transcriptional regulator
IS495_RS26060	COG0477	Major facilitator Superfamily
IS495_RS26065	COG1609	Transcriptional regulator
IS495_RS26070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS495_RS26080	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS495_RS26085	COG1129	ABC transporter
IS495_RS26115	COG1522	sequence-specific DNA binding
IS495_RS26120	COG0716	FMN binding
IS495_RS26135	COG3312	ion transport
IS495_RS26185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS495_RS26190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS495_RS26195	COG0573	inorganic phosphate transmembrane transporter activity
IS495_RS26200	COG0581	inorganic phosphate transmembrane transporter activity
IS495_RS26205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS495_RS26210	COG0704	Plays a role in the regulation of phosphate uptake
IS495_RS26220	COG2382	esterase
IS495_RS26225	COG0363	glucosamine-6-phosphate deaminase activity
IS495_RS26230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS495_RS26235	COG2252	PERMEase
IS495_RS26240	COG0431	NADPH-dependent FMN reductase
IS495_RS26245	COG2091	lysine biosynthetic process via aminoadipic acid
IS495_RS26275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IS495_RS26290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS495_RS26330	COG3344	reverse transcriptase
IS495_RS26385	COG4372	Transposase
IS495_RS26390	COG3436	PFAM IS66 Orf2 family protein
IS495_RS26560	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS495_RS26590	COG0739	heme binding
IS495_RS26600	COG2132	Multicopper oxidase
IS495_RS26620	COG2372	response to copper ion
IS495_RS26625	COG1276	copper resistance
IS495_RS26630	COG0745	RESPONSE REGULATOR receiver
IS495_RS26635	COG2205	protein histidine kinase activity
IS495_RS26650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IS495_RS26665	COG0789	Transcriptional regulator
IS495_RS26720	COG5499	transcription regulator containing HTH domain
IS495_RS26725	COG4680	protein conserved in bacteria
IS495_RS26790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IS495_RS26835	COG0523	cobalamin synthesis protein
IS495_RS26860	COG0523	cobalamin synthesis protein
IS495_RS26865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IS495_RS26870	COG0735	belongs to the Fur family
IS495_RS26915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS495_RS26940	COG0656	L-ascorbic acid biosynthetic process
IS495_RS26950	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS495_RS26975	COG5654	RES domain protein
IS495_RS26980	COG5642	Protein of unknown function (DUF2384)
IS495_RS27085	COG3344	reverse transcriptase
IS495_RS27300	COG3300	MHYT domain
IS495_RS27300	COG5001	Diguanylate cyclase
IS495_RS27375	COG0500	methyltransferase
IS495_RS27410	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IS495_RS27420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS495_RS27440	COG0523	cobalamin synthesis protein
IS495_RS27610	COG1522	sequence-specific DNA binding
IS495_RS27625	COG0604	alcohol dehydrogenase
IS495_RS27625	COG1028	Short-chain dehydrogenase reductase Sdr
IS495_RS27625	COG3321	synthase
IS495_RS27715	COG1358	cellular component organization or biogenesis
IS495_RS27735	COG4245	von Willebrand factor, type A
IS495_RS27745	COG4245	von Willebrand factor, type A
IS495_RS27750	COG4245	von Willebrand factor, type A
IS495_RS27770	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
IS495_RS27805	COG2144	transferase activity, transferring acyl groups
IS495_RS27870	COG4735	regulation of single-species biofilm formation
IS495_RS27915	COG3039	Transposase
IS495_RS28005	COG1475	DNA binding
IS495_RS28010	COG1475	DNA binding
IS495_RS28015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS495_RS28105	COG3941	tape measure
IS495_RS28255	COG1702	phosphate starvation-inducible protein PhoH
IS495_RS28260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS495_RS28330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IS495_RS28400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS495_RS28405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS495_RS28415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IS495_RS28460	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IS495_RS28610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IS495_RS28690	COG3344	reverse transcriptase
IS495_RS28725	COG3436	PFAM IS66 Orf2 family protein
IS495_RS28730	COG4372	Transposase
IS495_RS28805	COG4372	Transposase
IS495_RS28810	COG3436	PFAM IS66 Orf2 family protein
IS495_RS29035	COG2198	Histidine kinase
IS495_RS29035	COG5002	protein histidine kinase activity
IS495_RS29035	COG0784	Response regulator, receiver
IS495_RS29115	COG2003	Belongs to the UPF0758 family
IS495_RS29225	COG0768	penicillin binding
IS495_RS29305	COG3344	reverse transcriptase
IS495_RS29325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS495_RS29435	COG0741	lytic transglycosylase activity