locus-tag	class	description
C2D63_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2D63_RS00020	COG0187	DNA topoisomerase II activity
C2D63_RS00025	COG0561	phosphatase activity
C2D63_RS00040	COG2186	Transcriptional regulator
C2D63_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
C2D63_RS00050	COG0800	Aldolase
C2D63_RS00060	COG2271	Major facilitator Superfamily
C2D63_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
C2D63_RS00070	COG5645	(Lipo)protein
C2D63_RS00085	COG3645	SOS response
C2D63_RS00095	COG2188	Transcriptional regulator
C2D63_RS00110	COG2149	membrane
C2D63_RS00130	COG2610	gluconate transmembrane transporter activity
C2D63_RS00135	COG0583	DNA-binding transcription factor activity
C2D63_RS00140	COG2814	Major facilitator Superfamily
C2D63_RS00165	COG0028	Belongs to the TPP enzyme family
C2D63_RS00170	COG0440	acetolactate synthase activity
C2D63_RS00175	COG2197	response regulator
C2D63_RS00185	COG2271	Major facilitator Superfamily
C2D63_RS00225	COG2188	Transcriptional regulator
C2D63_RS00250	COG4580	involved in the transport of maltose and maltodextrins
C2D63_RS00255	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D63_RS00260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS00260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS00280	COG3384	dioxygenase
C2D63_RS00285	COG0583	DNA-binding transcription factor activity
C2D63_RS00290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2D63_RS00295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2D63_RS00300	COG2828	Protein conserved in bacteria
C2D63_RS00315	COG0697	spore germination
C2D63_RS00320	COG1263	PTS System
C2D63_RS00320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS00330	COG2814	Major facilitator Superfamily
C2D63_RS00340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D63_RS00365	COG0583	DNA-binding transcription factor activity
C2D63_RS00390	COG1464	Belongs to the NlpA lipoprotein family
C2D63_RS00405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2D63_RS00415	COG1064	alcohol dehydrogenase
C2D63_RS00450	COG0582	viral genome integration into host DNA
C2D63_RS00460	COG2211	Major facilitator Superfamily
C2D63_RS00465	COG1501	Belongs to the glycosyl hydrolase 31 family
C2D63_RS00475	COG1486	melibiose metabolic process
C2D63_RS00480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS00480	COG1263	PTS System
C2D63_RS00485	COG2982	Protein involved in outer membrane biogenesis
C2D63_RS00490	COG2233	PERMEase
C2D63_RS00495	COG0786	glutamate:sodium symporter activity
C2D63_RS00515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2D63_RS00540	COG3152	Membrane
C2D63_RS00550	COG1494	fructose-1,6-bisphosphatase
C2D63_RS00555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2D63_RS00560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D63_RS00565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2D63_RS00585	COG2860	membrane
C2D63_RS00595	COG2169	Transcriptional regulator
C2D63_RS00595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2D63_RS00600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2D63_RS00605	COG1561	YicC-like family, N-terminal region
C2D63_RS00620	COG1131	(ABC) transporter
C2D63_RS00625	COG0842	Transport permease protein
C2D63_RS00655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2D63_RS00690	COG1519	Transferase
C2D63_RS00695	COG1216	Glycosyl transferase, family 2
C2D63_RS00700	COG0438	transferase activity, transferring glycosyl groups
C2D63_RS00710	COG0859	PFAM glycosyl transferase family 9
C2D63_RS00735	COG0859	PFAM glycosyl transferase family 9
C2D63_RS00750	COG0156	8-amino-7-oxononanoate synthase activity
C2D63_RS00760	COG0463	Glycosyl transferase, family 2
C2D63_RS00765	COG2861	carbohydrate metabolic process
C2D63_RS00770	COG4942	peptidase
C2D63_RS00780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2D63_RS00785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2D63_RS00805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2D63_RS00815	COG2186	Transcriptional regulator
C2D63_RS00835	COG3722	fumarate hydratase activity
C2D63_RS00855	COG0625	glutathione transferase activity
C2D63_RS00865	COG3276	selenocysteine insertion sequence binding
C2D63_RS00870	COG1414	Transcriptional regulator
C2D63_RS00875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D63_RS00880	COG3977	Valine--pyruvate aminotransferase
C2D63_RS00885	COG0366	Alpha amylase catalytic
C2D63_RS00890	COG2992	FlgJ-related protein
C2D63_RS00895	COG2207	Transcriptional regulator
C2D63_RS00895	COG1609	Transcriptional regulator
C2D63_RS00900	COG4214	carbohydrate transport
C2D63_RS00910	COG4213	ABC transporter substrate-binding protein
C2D63_RS00925	COG4682	membrane
C2D63_RS00930	COG4682	membrane
C2D63_RS00935	COG3274	enterobacterial common antigen metabolic process
C2D63_RS00965	COG1278	Cold shock
C2D63_RS00970	COG2944	sequence-specific DNA binding
C2D63_RS00975	COG2814	Major facilitator Superfamily
C2D63_RS00995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D63_RS01005	COG1609	Transcriptional regulator
C2D63_RS01010	COG2885	chlorophyll binding
C2D63_RS01015	COG0243	molybdopterin cofactor binding
C2D63_RS01020	COG0456	acetyltransferase
C2D63_RS01025	COG2818	Glycosylase
C2D63_RS01030	COG5571	outer membrane autotransporter
C2D63_RS01035	COG2223	nitrite transmembrane transporter activity
C2D63_RS01060	COG0747	negative chemotaxis
C2D63_RS01065	COG0601	transmembrane transport
C2D63_RS01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS01075	COG0444	Belongs to the ABC transporter superfamily
C2D63_RS01080	COG4608	Belongs to the ABC transporter superfamily
C2D63_RS01090	COG2894	cell division
C2D63_RS01100	COG1215	transferase activity, transferring glycosyl groups
C2D63_RS01120	COG2194	sulfuric ester hydrolase activity
C2D63_RS01150	COG1215	transferase activity, transferring glycosyl groups
C2D63_RS01155	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2D63_RS01160	COG0457	Tetratricopeptide repeat
C2D63_RS01160	COG3118	belongs to the thioredoxin family
C2D63_RS01165	COG2199	diguanylate cyclase activity
C2D63_RS01165	COG2200	EAL domain
C2D63_RS01175	COG0612	Peptidase, M16
C2D63_RS01190	COG2982	Protein involved in outer membrane biogenesis
C2D63_RS01195	COG0477	Major facilitator Superfamily
C2D63_RS01200	COG1295	ribonuclease BN
C2D63_RS01205	COG0583	DNA-binding transcription factor activity
C2D63_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS01215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D63_RS01225	COG1454	alcohol dehydrogenase
C2D63_RS01235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D63_RS01240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2D63_RS01245	COG0671	phosphoesterase, PA-phosphatase related
C2D63_RS01265	COG0589	response to stress
C2D63_RS01275	COG0306	phosphate transporter
C2D63_RS01280	COG2081	HI0933 family
C2D63_RS01285	COG2239	Acts as a magnesium transporter
C2D63_RS01300	COG1124	(ABC) transporter
C2D63_RS01310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS01315	COG0601	transmembrane transport
C2D63_RS01320	COG0747	negative chemotaxis
C2D63_RS01330	COG3479	Phenolic acid decarboxylase
C2D63_RS01370	COG0628	permease
C2D63_RS01375	COG0477	Major facilitator Superfamily
C2D63_RS01385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2D63_RS01400	COG3714	YhhN family
C2D63_RS01410	COG3776	membrane
C2D63_RS01415	COG0742	ribosomal rna small subunit methyltransferase
C2D63_RS01420	COG0552	protein localization to endoplasmic reticulum
C2D63_RS01425	COG2884	Cell division ATP-binding protein ftsE
C2D63_RS01430	COG2177	Part of the ABC transporter FtsEX involved in
C2D63_RS01445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D63_RS01455	COG0683	leucine binding
C2D63_RS01470	COG0683	leucine binding
C2D63_RS01475	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS01525	COG0584	glycerophosphoryl diester phosphodiesterase
C2D63_RS01535	COG0405	Gamma-glutamyltransferase
C2D63_RS01540	COG1247	-acetyltransferase
C2D63_RS01550	COG0673	inositol 2-dehydrogenase activity
C2D63_RS01555	COG1741	Belongs to the pirin family
C2D63_RS01560	COG1609	Transcriptional regulator
C2D63_RS01565	COG3265	gluconokinase activity
C2D63_RS01570	COG2610	gluconate transmembrane transporter activity
C2D63_RS01580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D63_RS01605	COG0058	SHG alpha-glucan phosphorylase activity
C2D63_RS01610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2D63_RS01625	COG1349	DNA-binding transcription factor activity
C2D63_RS01635	COG0058	SHG alpha-glucan phosphorylase activity
C2D63_RS01640	COG1640	4-alpha-glucanotransferase
C2D63_RS01645	COG2610	gluconate transmembrane transporter activity
C2D63_RS01655	COG1040	competence protein
C2D63_RS01680	COG1918	ferrous iron import across plasma membrane
C2D63_RS01685	COG2183	response to ionizing radiation
C2D63_RS01690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2D63_RS01715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2D63_RS01720	COG1011	Hydrolase
C2D63_RS01730	COG0494	nUDIX hydrolase
C2D63_RS01735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2D63_RS01760	COG4796	Type ii and iii secretion system protein
C2D63_RS01775	COG3266	domain, Protein
C2D63_RS01780	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2D63_RS01785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D63_RS01810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2D63_RS01815	COG0402	S-adenosylhomocysteine deaminase activity
C2D63_RS01820	COG0738	Major facilitator superfamily
C2D63_RS01845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2D63_RS01850	COG1289	transmembrane transporter activity
C2D63_RS01860	COG1765	OsmC-like protein
C2D63_RS01865	COG3954	Phosphoribulokinase
C2D63_RS01875	COG0429	hydrolase of the alpha beta-hydrolase fold
C2D63_RS01880	COG0488	(ABC) transporter
C2D63_RS01895	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2D63_RS01900	COG1047	Peptidyl-prolyl cis-trans
C2D63_RS01910	COG0545	Peptidyl-prolyl cis-trans isomerase
C2D63_RS01915	COG2964	Protein conserved in bacteria
C2D63_RS01970	COG0051	transcription antitermination factor activity, RNA binding
C2D63_RS01995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2D63_RS02010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2D63_RS02075	COG0201	protein transport
C2D63_RS02100	COG0202	RNA polymerase activity
C2D63_RS02115	COG0789	Transcriptional regulator
C2D63_RS02120	COG3036	rescue of stalled ribosome
C2D63_RS02150	COG0758	DNA mediated transformation
C2D63_RS02160	COG0551	DNA topoisomerase type I activity
C2D63_RS02180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D63_RS02215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D63_RS02220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS02225	COG1309	transcriptional regulator
C2D63_RS02245	COG4145	pantothenate transmembrane transporter activity
C2D63_RS02250	COG3924	membrane
C2D63_RS02255	COG0439	Biotin carboxylase
C2D63_RS02260	COG0511	ligase activity, forming carbon-carbon bonds
C2D63_RS02285	COG2199	diguanylate cyclase activity
C2D63_RS02285	COG2200	EAL domain
C2D63_RS02290	COG1077	Cell shape determining protein MreB Mrl
C2D63_RS02295	COG1792	Involved in formation and maintenance of cell shape
C2D63_RS02300	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2D63_RS02310	COG1530	ribonuclease E activity
C2D63_RS02315	COG3164	Protein of unknown function
C2D63_RS02320	COG0312	modulator of DNA gyrase
C2D63_RS02325	COG0583	DNA-binding transcription factor activity
C2D63_RS02340	COG1289	transmembrane transporter activity
C2D63_RS02345	COG2732	(Barnase) inhibitor
C2D63_RS02380	COG0471	metal ion transport
C2D63_RS02385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D63_RS02390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D63_RS02415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D63_RS02420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D63_RS02425	COG3105	Protein conserved in bacteria
C2D63_RS02430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2D63_RS02450	COG0625	glutathione transferase activity
C2D63_RS02455	COG2969	positive regulation of protein catabolic process
C2D63_RS02465	COG0493	'glutamate synthase
C2D63_RS02470	COG0069	glutamate synthase activity
C2D63_RS02470	COG0070	glutamate synthase
C2D63_RS02470	COG0067	glutamate synthase
C2D63_RS02475	COG1242	4 iron, 4 sulfur cluster binding
C2D63_RS02480	COG2271	Major facilitator Superfamily
C2D63_RS02485	COG1063	alcohol dehydrogenase
C2D63_RS02490	COG1312	Catalyzes the dehydration of D-mannonate
C2D63_RS02495	COG2198	Histidine kinase
C2D63_RS02495	COG0784	Response regulator, receiver
C2D63_RS02495	COG5002	protein histidine kinase activity
C2D63_RS02500	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2D63_RS02505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2D63_RS02510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS02520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS02525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2D63_RS02530	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2D63_RS02535	COG1137	ATPase activity
C2D63_RS02540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2D63_RS02545	COG3117	lipopolysaccharide transmembrane transporter activity
C2D63_RS02550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2D63_RS02560	COG0530	calcium, potassium:sodium antiporter activity
C2D63_RS02565	COG1127	ABC transporter
C2D63_RS02570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2D63_RS02575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2D63_RS02580	COG2854	intermembrane phospholipid transfer
C2D63_RS02585	COG3113	response to antibiotic
C2D63_RS02590	COG5007	Belongs to the BolA IbaG family
C2D63_RS02600	COG3423	Transcriptional regulator
C2D63_RS02605	COG0142	geranyltranstransferase activity
C2D63_RS02620	COG0697	spore germination
C2D63_RS02630	COG2027	D-alanyl-D-alanine carboxypeptidase
C2D63_RS02640	COG1534	Rna-binding protein
C2D63_RS02650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2D63_RS02655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2D63_RS02665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2D63_RS02705	COG0195	Participates in both transcription termination and antitermination
C2D63_RS02750	COG0814	amino acid
C2D63_RS02755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D63_RS02760	COG0826	peptidase U32
C2D63_RS02765	COG0826	peptidase U32
C2D63_RS02770	COG3154	lipid carrier protein
C2D63_RS02775	COG3153	acetyltransferase
C2D63_RS02790	COG0693	protein deglycase activity
C2D63_RS02795	COG0702	epimerase
C2D63_RS02800	COG0701	Predicted permease
C2D63_RS02805	COG2823	Periplasmic or secreted lipoprotein
C2D63_RS02825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2D63_RS02840	COG1063	alcohol dehydrogenase
C2D63_RS02845	COG3775	system Galactitol-specific IIC component
C2D63_RS02850	COG3414	Phosphotransferase system galactitol-specific IIB component
C2D63_RS02855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS02865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS02865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS02870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS02870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS02870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS02875	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D63_RS02885	COG1349	DNA-binding transcription factor activity
C2D63_RS02890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D63_RS02895	COG2721	sulfolactate sulfo-lyase activity
C2D63_RS02905	COG2271	Major facilitator Superfamily
C2D63_RS02915	COG2084	Dehydrogenase
C2D63_RS02920	COG1929	Belongs to the glycerate kinase type-1 family
C2D63_RS02940	COG1741	Belongs to the pirin family
C2D63_RS02945	COG0583	DNA-binding transcription factor activity
C2D63_RS02950	COG3152	Membrane
C2D63_RS02955	COG0435	Glutathione S-transferase
C2D63_RS02960	COG2259	Doxx family
C2D63_RS02970	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2D63_RS02975	COG4575	ribosome binding
C2D63_RS02980	COG1422	Protein of unknown function (DUF1090)
C2D63_RS02990	COG0586	Pfam SNARE associated Golgi protein
C2D63_RS02995	COG2186	Transcriptional regulator
C2D63_RS03000	COG2271	Major facilitator Superfamily
C2D63_RS03010	COG2721	sulfolactate sulfo-lyase activity
C2D63_RS03025	COG0861	Integral membrane protein TerC family
C2D63_RS03030	COG0673	inositol 2-dehydrogenase activity
C2D63_RS03035	COG1451	nucleotide metabolic process
C2D63_RS03055	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2D63_RS03055	COG1902	pentaerythritol trinitrate reductase activity
C2D63_RS03105	COG1695	Transcriptional regulator
C2D63_RS03110	COG2375	cellular response to nickel ion
C2D63_RS03125	COG1461	Dihydroxyacetone kinase
C2D63_RS03130	COG2376	Dihydroxyacetone kinase
C2D63_RS03200	COG3247	response to pH
C2D63_RS03210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS03210	COG2198	Histidine kinase
C2D63_RS03210	COG2205	protein histidine kinase activity
C2D63_RS03210	COG0784	Response regulator, receiver
C2D63_RS03215	COG2197	response regulator
C2D63_RS03240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2D63_RS03245	COG0358	DNA primase activity
C2D63_RS03250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2D63_RS03305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2D63_RS03320	COG4991	sh3 domain protein
C2D63_RS03325	COG3025	triphosphatase activity
C2D63_RS03345	COG2960	long-chain fatty acid transporting porin activity
C2D63_RS03360	COG3384	dioxygenase
C2D63_RS03365	COG0754	glutathionylspermidine amidase activity
C2D63_RS03380	COG0494	nUDIX hydrolase
C2D63_RS03385	COG3151	Protein conserved in bacteria
C2D63_RS03390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2D63_RS03395	COG3150	esterase
C2D63_RS03405	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2D63_RS03415	COG0642	Histidine kinase
C2D63_RS03425	COG3111	PFAM Bacterial OB fold (BOF) protein
C2D63_RS03430	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2D63_RS03435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2D63_RS03440	COG0204	Acyl-transferase
C2D63_RS03445	COG2132	Multicopper oxidase
C2D63_RS03450	COG1032	radical SAM domain protein
C2D63_RS03460	COG0656	L-ascorbic acid biosynthetic process
C2D63_RS03465	COG1979	alcohol dehydrogenase
C2D63_RS03470	COG2207	Transcriptional regulator
C2D63_RS03475	COG0586	Pfam SNARE associated Golgi protein
C2D63_RS03480	COG0626	cystathionine gamma-synthase activity
C2D63_RS03490	COG0848	biopolymer transport protein
C2D63_RS03495	COG2211	Major facilitator Superfamily
C2D63_RS03520	COG0625	glutathione transferase activity
C2D63_RS03530	COG0754	glutathionylspermidine amidase activity
C2D63_RS03535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D63_RS03560	COG0626	cystathionine gamma-synthase activity
C2D63_RS03605	COG1811	Na channel or pump
C2D63_RS03610	COG1982	Orn Lys Arg decarboxylase major
C2D63_RS03615	COG2211	Major facilitator Superfamily
C2D63_RS03630	COG1194	a g-specific adenine glycosylase
C2D63_RS03640	COG3171	Protein conserved in bacteria
C2D63_RS03650	COG4214	carbohydrate transport
C2D63_RS03665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2D63_RS03680	COG0762	integral membrane protein
C2D63_RS03685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2D63_RS03690	COG2805	Type II/IV secretion system protein
C2D63_RS03710	COG0189	ligase activity
C2D63_RS03715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2D63_RS03720	COG2356	endonuclease I
C2D63_RS03730	COG2814	Major facilitator Superfamily
C2D63_RS03760	COG0501	Belongs to the peptidase M48B family
C2D63_RS03765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D63_RS03780	COG0191	fructose-bisphosphate aldolase activity
C2D63_RS03785	COG0668	transmembrane transport
C2D63_RS03795	COG2968	Membrane
C2D63_RS03810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D63_RS03815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2D63_RS03835	COG0006	proline dipeptidase activity
C2D63_RS03840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D63_RS03845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D63_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS03870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2D63_RS03890	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS03895	COG1737	Transcriptional regulator
C2D63_RS03905	COG1272	protein, Hemolysin III
C2D63_RS03915	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2D63_RS03925	COG0716	FMN binding
C2D63_RS03930	COG4974	Belongs to the 'phage' integrase family
C2D63_RS03940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2D63_RS03960	COG4942	peptidase
C2D63_RS03970	COG2814	Major facilitator Superfamily
C2D63_RS03985	COG0667	Aldo Keto reductase
C2D63_RS04025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2D63_RS04030	COG1393	Belongs to the ArsC family
C2D63_RS04045	COG1538	Outer membrane efflux protein
C2D63_RS04050	COG1289	transmembrane transporter activity
C2D63_RS04065	COG3592	Divergent 4Fe-4S mono-cluster
C2D63_RS04070	COG2388	GCN5-related N-acetyl-transferase
C2D63_RS04080	COG3539	Fimbrial protein
C2D63_RS04085	COG3539	Fimbrial protein
C2D63_RS04090	COG3539	Fimbrial protein
C2D63_RS04095	COG3188	usher protein
C2D63_RS04100	COG3121	Chaperone
C2D63_RS04105	COG3539	Fimbrial protein
C2D63_RS04115	COG4974	Belongs to the 'phage' integrase family
C2D63_RS04120	COG0582	viral genome integration into host DNA
C2D63_RS04125	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D63_RS04130	COG1846	Transcriptional regulator
C2D63_RS04135	COG0697	spore germination
C2D63_RS04185	COG0667	Aldo Keto reductase
C2D63_RS04190	COG0814	amino acid
C2D63_RS04205	COG0183	Belongs to the thiolase family
C2D63_RS04215	COG0823	Involved in the tonB-independent uptake of proteins
C2D63_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS04225	COG2814	Major facilitator Superfamily
C2D63_RS04255	COG3842	ATPase activity
C2D63_RS04260	COG0395	ABC-type sugar transport system, permease component
C2D63_RS04265	COG1175	transmembrane transport
C2D63_RS04270	COG1917	Cupin 2, conserved barrel domain protein
C2D63_RS04275	COG1794	racemase activity, acting on amino acids and derivatives
C2D63_RS04280	COG0583	DNA-binding transcription factor activity
C2D63_RS04290	COG1609	Transcriptional regulator
C2D63_RS04295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS04300	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS04305	COG2186	Transcriptional regulator
C2D63_RS04315	COG1609	Transcriptional regulator
C2D63_RS04330	COG0667	Aldo Keto reductase
C2D63_RS04340	COG0861	Integral membrane protein TerC family
C2D63_RS04370	COG2165	general secretion pathway protein
C2D63_RS04375	COG4795	General secretion pathway protein
C2D63_RS04385	COG4967	type IV pilus modification protein PilV
C2D63_RS04390	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2D63_RS04395	COG1025	Belongs to the peptidase M16 family
C2D63_RS04400	COG1074	ATP-dependent DNA helicase activity
C2D63_RS04405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2D63_RS04415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2D63_RS04415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2D63_RS04420	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D63_RS04425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2D63_RS04455	COG4656	Part of a membrane complex involved in electron transport
C2D63_RS04460	COG1454	alcohol dehydrogenase
C2D63_RS04460	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS04490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2D63_RS04655	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2D63_RS04660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2D63_RS04665	COG2166	iron-sulfur cluster assembly
C2D63_RS04670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2D63_RS04680	COG0583	DNA-binding transcription factor activity
C2D63_RS04685	COG2363	Small membrane protein
C2D63_RS04695	COG1349	DNA-binding transcription factor activity
C2D63_RS04715	COG0738	Major facilitator superfamily
C2D63_RS04720	COG0235	Class ii aldolase
C2D63_RS04725	COG1454	alcohol dehydrogenase
C2D63_RS04740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D63_RS04755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2D63_RS04760	COG2011	ABC-type metal ion transport system permease component
C2D63_RS04765	COG1464	Belongs to the NlpA lipoprotein family
C2D63_RS04770	COG0477	Major facilitator Superfamily
C2D63_RS04780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D63_RS04785	COG1760	l-serine dehydratase
C2D63_RS04790	COG0814	amino acid
C2D63_RS04795	COG1611	Belongs to the LOG family
C2D63_RS04810	COG3098	single-species biofilm formation
C2D63_RS04815	COG0564	pseudouridine synthase activity
C2D63_RS04820	COG0716	FMN binding
C2D63_RS04825	COG2271	Major facilitator Superfamily
C2D63_RS04830	COG4948	Mandelate Racemase Muconate Lactonizing
C2D63_RS04835	COG4948	Mandelate Racemase Muconate Lactonizing
C2D63_RS04840	COG1929	Belongs to the glycerate kinase type-1 family
C2D63_RS04850	COG2205	protein histidine kinase activity
C2D63_RS04850	COG3437	response regulator, receiver
C2D63_RS04850	COG3850	Histidine kinase
C2D63_RS04850	COG4999	Histidine kinase
C2D63_RS04860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2D63_RS04865	COG3956	TIGRFAM MazG family protein
C2D63_RS04885	COG0602	queuosine metabolic process
C2D63_RS04890	COG0720	synthase
C2D63_RS04910	COG2234	aminopeptidase activity
C2D63_RS04970	COG4942	peptidase
C2D63_RS04970	COG1388	LysM domain
C2D63_RS04975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2D63_RS05000	COG0163	prenyltransferase activity
C2D63_RS05005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2D63_RS05030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS05035	COG4558	Periplasmic binding protein
C2D63_RS05040	COG3720	iron ion transport
C2D63_RS05060	COG0679	Auxin Efflux Carrier
C2D63_RS05075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D63_RS05080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D63_RS05085	COG1121	(ABC) transporter
C2D63_RS05095	COG1609	Transcriptional regulator
C2D63_RS05100	COG1940	carbohydrate kinase activity
C2D63_RS05105	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D63_RS05110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS05115	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS05120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS05125	COG4580	involved in the transport of maltose and maltodextrins
C2D63_RS05135	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS05145	COG0309	Hydrogenase expression formation protein (HypE)
C2D63_RS05150	COG0409	Hydrogenase expression formation protein
C2D63_RS05155	COG0298	carbon dioxide binding
C2D63_RS05160	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2D63_RS05175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D63_RS05180	COG0651	ATP synthesis coupled electron transport
C2D63_RS05185	COG0650	Formate hydrogenlyase subunit 4
C2D63_RS05190	COG3261	NADH dehydrogenase
C2D63_RS05190	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2D63_RS05195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D63_RS05200	COG3260	NADH ubiquinone oxidoreductase 20
C2D63_RS05210	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2D63_RS05220	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS05225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS05225	COG1263	PTS System
C2D63_RS05230	COG1609	Transcriptional regulator
C2D63_RS05235	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D63_RS05240	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2D63_RS05245	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D63_RS05270	COG1349	DNA-binding transcription factor activity
C2D63_RS05275	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS05290	COG3732	PTS system glucitol sorbitol-specific
C2D63_RS05295	COG3730	PTS system glucitol sorbitol-specific
C2D63_RS05300	COG2951	lytic endotransglycosylase activity
C2D63_RS05310	COG1121	(ABC) transporter
C2D63_RS05315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D63_RS05320	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2D63_RS05325	COG1546	Belongs to the CinA family
C2D63_RS05345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2D63_RS05375	COG2823	Periplasmic or secreted lipoprotein
C2D63_RS05380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D63_RS05385	COG1238	metal cluster binding
C2D63_RS05405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2D63_RS05410	COG2814	Major facilitator Superfamily
C2D63_RS05415	COG1566	PFAM secretion protein HlyD family protein
C2D63_RS05420	COG1846	Transcriptional regulator
C2D63_RS05430	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2D63_RS05440	COG4176	ABC-type proline glycine betaine transport system permease component
C2D63_RS05455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2D63_RS05465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2D63_RS05470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D63_RS05475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D63_RS05480	COG4575	ribosome binding
C2D63_RS05495	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D63_RS05510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2D63_RS05515	COG0640	Transcriptional regulator
C2D63_RS05525	COG0583	DNA-binding transcription factor activity
C2D63_RS05530	COG3284	Transcriptional regulator
C2D63_RS05540	COG3539	Fimbrial protein
C2D63_RS05545	COG3121	Chaperone
C2D63_RS05565	COG3188	usher protein
C2D63_RS05580	COG2197	response regulator
C2D63_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS05605	COG0235	Class ii aldolase
C2D63_RS05615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS05645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D63_RS05695	COG0431	NADPH-dependent FMN reductase
C2D63_RS05710	COG2271	Major facilitator Superfamily
C2D63_RS05715	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2D63_RS05720	COG0477	Major facilitator Superfamily
C2D63_RS05725	COG3622	Belongs to the hyi family
C2D63_RS05750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS05755	COG3708	Transcriptional regulator
C2D63_RS05755	COG2207	Transcriptional regulator
C2D63_RS05785	COG2867	negative regulation of translational initiation
C2D63_RS05800	COG0497	DNA recombination
C2D63_RS05815	COG4536	flavin adenine dinucleotide binding
C2D63_RS05820	COG4137	Cytochrome C assembly protein
C2D63_RS05825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2D63_RS05860	COG2885	chlorophyll binding
C2D63_RS05865	COG2199	diguanylate cyclase activity
C2D63_RS05875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D63_RS05880	COG0287	Prephenate dehydrogenase
C2D63_RS05880	COG1605	Chorismate mutase
C2D63_RS05890	COG1605	Chorismate mutase
C2D63_RS05890	COG0077	Prephenate dehydratase
C2D63_RS05900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2D63_RS05905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D63_RS05920	COG0542	response to heat
C2D63_RS05945	COG0477	Major facilitator Superfamily
C2D63_RS05950	COG5544	Lipoprotein
C2D63_RS05955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2D63_RS05965	COG3148	PFAM DTW domain containing protein
C2D63_RS05970	COG3118	belongs to the thioredoxin family
C2D63_RS05975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D63_RS05990	COG0513	Belongs to the DEAD box helicase family
C2D63_RS06000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2D63_RS06015	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2D63_RS06020	COG3026	antisigma factor binding
C2D63_RS06025	COG3086	response to oxidative stress
C2D63_RS06035	COG0681	Belongs to the peptidase S26 family
C2D63_RS06055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2D63_RS06065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D63_RS06070	COG1737	Transcriptional regulator
C2D63_RS06075	COG0560	Phosphoserine phosphatase
C2D63_RS06090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2D63_RS06090	COG0047	phosphoribosylformylglycinamidine synthase activity
C2D63_RS06095	COG2205	protein histidine kinase activity
C2D63_RS06100	COG3170	Tfp pilus assembly protein FimV
C2D63_RS06105	COG2204	response regulator
C2D63_RS06110	COG0347	Belongs to the P(II) protein family
C2D63_RS06115	COG1017	nitric oxide dioxygenase activity
C2D63_RS06115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D63_RS06125	COG2259	Doxx family
C2D63_RS06135	COG0457	Tetratricopeptide repeat
C2D63_RS06140	COG0477	Major facilitator Superfamily
C2D63_RS06140	COG2814	Major facilitator Superfamily
C2D63_RS06145	COG2017	converts alpha-aldose to the beta-anomer
C2D63_RS06150	COG2814	Major facilitator Superfamily
C2D63_RS06155	COG3711	transcriptional antiterminator
C2D63_RS06160	COG3683	transport system, periplasmic component
C2D63_RS06165	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2D63_RS06195	COG0822	iron-sulfur transferase activity
C2D63_RS06215	COG0633	Ferredoxin
C2D63_RS06220	COG2975	iron-sulfur cluster assembly
C2D63_RS06240	COG2897	thiosulfate sulfurtransferase activity
C2D63_RS06245	COG2373	Large extracellular alpha-helical protein
C2D63_RS06250	COG4953	penicillin-binding protein 1C
C2D63_RS06280	COG2976	Protein conserved in bacteria
C2D63_RS06300	COG1645	bacterial-type flagellum-dependent swarming motility
C2D63_RS06310	COG0516	GMP reductase activity
C2D63_RS06310	COG0517	IMP dehydrogenase activity
C2D63_RS06320	COG3119	arylsulfatase activity
C2D63_RS06325	COG0641	radical SAM
C2D63_RS06345	COG2200	EAL domain
C2D63_RS06360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2D63_RS06375	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS06385	COG2233	PERMEase
C2D63_RS06400	COG1393	Belongs to the ArsC family
C2D63_RS06405	COG4783	chaperone-mediated protein folding
C2D63_RS06410	COG0628	permease
C2D63_RS06415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2D63_RS06420	COG2716	regulation of RNA biosynthetic process
C2D63_RS06430	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2D63_RS06440	COG2321	neutral zinc metallopeptidase
C2D63_RS06445	COG1444	tRNA N-acetyltransferase activity
C2D63_RS06450	COG0400	carboxylic ester hydrolase activity
C2D63_RS06465	COG1393	Belongs to the ArsC family
C2D63_RS06475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D63_RS06480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2D63_RS06480	COG0493	'glutamate synthase
C2D63_RS06490	COG5342	invasion associated locus B
C2D63_RS06495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D63_RS06500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D63_RS06510	COG4810	utilization protein
C2D63_RS06600	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D63_RS06620	COG2837	iron assimilation
C2D63_RS06630	COG4150	thiosulfate binding
C2D63_RS06635	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2D63_RS06640	COG4208	sulfate ABC transporter
C2D63_RS06645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2D63_RS06655	COG4319	ketosteroid isomerase
C2D63_RS06690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2D63_RS06710	COG3530	Putative quorum-sensing-regulated virulence factor
C2D63_RS06715	COG0385	Bile acid
C2D63_RS06720	COG0583	DNA-binding transcription factor activity
C2D63_RS06755	COG3415	Transposase
C2D63_RS06760	COG3415	Transposase
C2D63_RS06775	COG2199	diguanylate cyclase activity
C2D63_RS06775	COG2200	EAL domain
C2D63_RS06780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D63_RS06795	COG0667	Aldo Keto reductase
C2D63_RS06800	COG3961	Belongs to the TPP enzyme family
C2D63_RS06815	COG3279	Response regulator of the LytR AlgR family
C2D63_RS06820	COG3275	phosphorelay sensor kinase activity
C2D63_RS06825	COG0436	Aminotransferase
C2D63_RS06835	COG2807	transmembrane transport
C2D63_RS06840	COG0590	tRNA wobble adenosine to inosine editing
C2D63_RS06845	COG0583	DNA-binding transcription factor activity
C2D63_RS06865	COG2116	formate transmembrane transporter activity
C2D63_RS06870	COG2853	Lipoprotein
C2D63_RS06880	COG3691	Protein conserved in bacteria
C2D63_RS06895	COG2062	phosphohistidine phosphatase, SixA
C2D63_RS06920	COG0730	response to heat
C2D63_RS06925	COG3101	peptidyl-lysine hydroxylation
C2D63_RS06940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D63_RS06960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D63_RS06970	COG0586	Pfam SNARE associated Golgi protein
C2D63_RS06980	COG0285	dihydrofolate synthase activity
C2D63_RS06985	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2D63_RS06990	COG1286	toxin biosynthetic process
C2D63_RS06995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2D63_RS07000	COG0163	prenyltransferase activity
C2D63_RS07020	COG4160	amino acid transport
C2D63_RS07025	COG4598	ABC transporter
C2D63_RS07035	COG1090	epimerase
C2D63_RS07040	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2D63_RS07045	COG0625	glutathione transferase activity
C2D63_RS07050	COG0625	glutathione transferase activity
C2D63_RS07055	COG0622	Phosphoesterase
C2D63_RS07060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2D63_RS07065	COG0280	phosphate acetyltransferase
C2D63_RS07065	COG0857	belongs to the CobB CobQ family
C2D63_RS07085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D63_RS07090	COG0490	domain, Protein
C2D63_RS07090	COG0471	metal ion transport
C2D63_RS07100	COG0436	Aminotransferase
C2D63_RS07105	COG0583	DNA-binding transcription factor activity
C2D63_RS07150	COG0839	Belongs to the complex I subunit 6 family
C2D63_RS07160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2D63_RS07165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D63_RS07180	COG2153	protein acetylation
C2D63_RS07185	COG1169	isochorismate synthase
C2D63_RS07210	COG0318	PFAM AMP-dependent synthetase and ligase
C2D63_RS07220	COG5464	transposase or invertase
C2D63_RS07235	COG1414	Transcriptional regulator
C2D63_RS07245	COG2271	Major facilitator Superfamily
C2D63_RS07255	COG0247	lactate metabolic process
C2D63_RS07265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2D63_RS07270	COG2271	Major facilitator Superfamily
C2D63_RS07275	COG0584	glycerophosphoryl diester phosphodiesterase
C2D63_RS07280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D63_RS07305	COG2205	protein histidine kinase activity
C2D63_RS07305	COG0784	Response regulator, receiver
C2D63_RS07315	COG2198	Histidine kinase
C2D63_RS07315	COG0642	Histidine kinase
C2D63_RS07330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2D63_RS07330	COG2169	Transcriptional regulator
C2D63_RS07335	COG3145	DNA-N1-methyladenine dioxygenase activity
C2D63_RS07340	COG4615	Cyclic peptide transporter
C2D63_RS07345	COG2239	Acts as a magnesium transporter
C2D63_RS07350	COG0659	secondary active sulfate transmembrane transporter activity
C2D63_RS07365	COG0628	permease
C2D63_RS07390	COG1349	DNA-binding transcription factor activity
C2D63_RS07395	COG0494	nUDIX hydrolase
C2D63_RS07415	COG1061	Type III restriction enzyme res subunit
C2D63_RS07420	COG1187	pseudouridine synthase activity
C2D63_RS07425	COG2814	Major facilitator Superfamily
C2D63_RS07435	COG4172	Belongs to the ABC transporter superfamily
C2D63_RS07440	COG4239	(ABC) transporter, permease
C2D63_RS07445	COG4174	ABC transporter (Permease)
C2D63_RS07450	COG4166	transmembrane transport
C2D63_RS07455	COG2200	EAL domain
C2D63_RS07460	COG0791	NLP P60 protein
C2D63_RS07465	COG0671	phosphoesterase, PA-phosphatase related
C2D63_RS07470	COG0523	cobalamin synthesis protein
C2D63_RS07475	COG0246	Mannitol dehydrogenase
C2D63_RS07480	COG1312	Catalyzes the dehydration of D-mannonate
C2D63_RS07495	COG2814	Major facilitator Superfamily
C2D63_RS07500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS07500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS07505	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D63_RS07510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS07510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2D63_RS07510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS07520	COG2855	membrane
C2D63_RS07525	COG0583	DNA-binding transcription factor activity
C2D63_RS07530	COG0833	amino acid
C2D63_RS07535	COG4771	TonB-dependent receptor
C2D63_RS07550	COG2311	Membrane
C2D63_RS07565	COG1129	ABC transporter
C2D63_RS07575	COG2949	membrane
C2D63_RS07585	COG1346	cytolysis
C2D63_RS07595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2D63_RS07600	COG3659	wide pore channel activity
C2D63_RS07615	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS07620	COG1538	Outer membrane efflux protein
C2D63_RS07625	COG0586	Pfam SNARE associated Golgi protein
C2D63_RS07635	COG1686	Belongs to the peptidase S11 family
C2D63_RS07645	COG0277	FAD linked oxidase domain protein
C2D63_RS07650	COG1472	Belongs to the glycosyl hydrolase 3 family
C2D63_RS07655	COG1732	Glycine betaine
C2D63_RS07660	COG1174	glycine betaine transport
C2D63_RS07665	COG1125	glycine betaine transport
C2D63_RS07670	COG1174	glycine betaine transport
C2D63_RS07680	COG3275	phosphorelay sensor kinase activity
C2D63_RS07690	COG4807	Protein conserved in bacteria
C2D63_RS07710	COG5455	response to cobalt ion
C2D63_RS07715	COG0583	DNA-binding transcription factor activity
C2D63_RS07720	COG2252	PERMEase
C2D63_RS07730	COG0583	DNA-binding transcription factor activity
C2D63_RS07735	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C2D63_RS07775	COG0351	phosphomethylpyrimidine kinase
C2D63_RS07780	COG1830	Aldolase
C2D63_RS07815	COG1070	Carbohydrate kinase
C2D63_RS07825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D63_RS07830	COG4948	Mandelate Racemase Muconate Lactonizing
C2D63_RS07835	COG0747	negative chemotaxis
C2D63_RS07840	COG0601	transmembrane transport
C2D63_RS07845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS07850	COG0444	Belongs to the ABC transporter superfamily
C2D63_RS07855	COG4608	Belongs to the ABC transporter superfamily
C2D63_RS07865	COG0826	peptidase U32
C2D63_RS07870	COG0745	RESPONSE REGULATOR receiver
C2D63_RS07875	COG2205	protein histidine kinase activity
C2D63_RS07900	COG1301	dicarboxylic acid transport
C2D63_RS07920	COG5002	protein histidine kinase activity
C2D63_RS07925	COG0443	Heat shock 70 kDa protein
C2D63_RS07930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2D63_RS07945	COG2982	Protein involved in outer membrane biogenesis
C2D63_RS07950	COG1253	flavin adenine dinucleotide binding
C2D63_RS08005	COG0110	maltose O-acetyltransferase activity
C2D63_RS08010	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2D63_RS08015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D63_RS08020	COG1051	belongs to the nudix hydrolase family
C2D63_RS08025	COG0297	glycogen (starch) synthase activity
C2D63_RS08090	COG0438	transferase activity, transferring glycosyl groups
C2D63_RS08095	COG1442	glycosyl transferase family 8
C2D63_RS08095	COG1216	Glycosyl transferase, family 2
C2D63_RS08105	COG0463	Glycosyl transferase, family 2
C2D63_RS08130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2D63_RS08160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D63_RS08165	COG0583	DNA-binding transcription factor activity
C2D63_RS08175	COG0531	amino acid
C2D63_RS08180	COG0640	Transcriptional regulator
C2D63_RS08185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2D63_RS08190	COG2925	Exonuclease
C2D63_RS08205	COG1289	transmembrane transporter activity
C2D63_RS08225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2D63_RS08235	COG1942	4-Oxalocrotonate Tautomerase
C2D63_RS08240	COG0583	DNA-binding transcription factor activity
C2D63_RS08245	COG0095	Lipoate-protein ligase
C2D63_RS08250	COG0477	Major facilitator Superfamily
C2D63_RS08260	COG3300	MHYT domain
C2D63_RS08260	COG5001	Diguanylate cyclase
C2D63_RS08265	COG3615	Tellurite resistance protein tehB
C2D63_RS08290	COG3706	GGDEF domain
C2D63_RS08330	COG4227	nucleotidyltransferase activity
C2D63_RS08370	COG3504	Conjugal transfer protein
C2D63_RS08425	COG0500	methyltransferase
C2D63_RS08455	COG2382	esterase
C2D63_RS08540	COG4771	TonB-dependent receptor
C2D63_RS08545	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2D63_RS08565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2D63_RS08565	COG3433	isochorismatase activity
C2D63_RS08565	COG2226	methyltransferase
C2D63_RS08580	COG1132	(ABC) transporter
C2D63_RS08585	COG2814	Major facilitator Superfamily
C2D63_RS08590	COG1169	isochorismate synthase
C2D63_RS08595	COG0582	viral genome integration into host DNA
C2D63_RS08605	COG0534	Mate efflux family protein
C2D63_RS08615	COG0025	NhaP-type Na H and K H
C2D63_RS08620	COG1309	transcriptional regulator
C2D63_RS08625	COG0604	alcohol dehydrogenase
C2D63_RS08645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2D63_RS08665	COG1376	ErfK ybiS ycfS ynhG family protein
C2D63_RS08680	COG0251	oxidation-reduction process
C2D63_RS08700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D63_RS08710	COG1418	mRNA catabolic process
C2D63_RS08715	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2D63_RS08720	COG3727	T/G mismatch-specific endonuclease activity
C2D63_RS08725	COG0697	spore germination
C2D63_RS08730	COG2354	Protein conserved in bacteria
C2D63_RS08760	COG0366	Alpha amylase catalytic
C2D63_RS08765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS08775	COG0765	amino acid transport
C2D63_RS08780	COG1126	abc transporter atp-binding protein
C2D63_RS08785	COG2197	response regulator
C2D63_RS08795	COG2197	response regulator
C2D63_RS08830	COG3012	SEC-C Motif Domain Protein
C2D63_RS08830	COG3318	Belongs to the UPF0149 family
C2D63_RS08835	COG0814	amino acid
C2D63_RS08845	COG1528	Iron-storage protein
C2D63_RS08860	COG0477	Major facilitator Superfamily
C2D63_RS08870	COG2211	Major facilitator Superfamily
C2D63_RS08875	COG1528	Iron-storage protein
C2D63_RS08880	COG1879	ABC-type sugar transport system periplasmic component
C2D63_RS08890	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS08915	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2D63_RS08925	COG3102	Protein conserved in bacteria
C2D63_RS08945	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2D63_RS08950	COG1801	Protein of unknown function DUF72
C2D63_RS08955	COG1335	isochorismatase
C2D63_RS08965	COG0494	nUDIX hydrolase
C2D63_RS08990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2D63_RS09000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2D63_RS09005	COG0739	heme binding
C2D63_RS09010	COG1560	Kdo2-lipid A biosynthetic process
C2D63_RS09020	COG1737	Transcriptional regulator
C2D63_RS09025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2D63_RS09030	COG0129	dihydroxy-acid dehydratase activity
C2D63_RS09035	COG0800	Aldolase
C2D63_RS09045	COG3141	response to X-ray
C2D63_RS09050	COG2979	Protein of unknown function (DUF533)
C2D63_RS09055	COG1770	oligopeptidase
C2D63_RS09060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D63_RS09070	COG2372	response to copper ion
C2D63_RS09075	COG1276	copper resistance
C2D63_RS09090	COG2990	Protein conserved in bacteria
C2D63_RS09115	COG3008	intermembrane lipid transfer
C2D63_RS09120	COG2995	paraquat-inducible protein a
C2D63_RS09125	COG1956	GAF domain-containing protein
C2D63_RS09145	COG2814	Major facilitator Superfamily
C2D63_RS09150	COG1414	Transcriptional regulator
C2D63_RS09180	COG0768	penicillin binding
C2D63_RS09185	COG2226	methyltransferase
C2D63_RS09200	COG3716	PTS system mannose fructose sorbose family IID component
C2D63_RS09205	COG3715	PTS system
C2D63_RS09210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS09210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS09215	COG1253	flavin adenine dinucleotide binding
C2D63_RS09220	COG2200	EAL domain
C2D63_RS09225	COG1760	l-serine dehydratase
C2D63_RS09245	COG0251	oxidation-reduction process
C2D63_RS09250	COG1199	ATP-dependent helicase activity
C2D63_RS09260	COG3065	identical protein binding
C2D63_RS09270	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2D63_RS09280	COG2894	cell division
C2D63_RS09295	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2D63_RS09325	COG2719	SpoVR family
C2D63_RS09345	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2D63_RS09355	COG4774	siderophore transport
C2D63_RS09370	COG2308	Evidence 4 Homologs of previously reported genes of
C2D63_RS09410	COG0583	DNA-binding transcription factor activity
C2D63_RS09415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2D63_RS09430	COG1882	Formate acetyltransferase
C2D63_RS09460	COG0583	DNA-binding transcription factor activity
C2D63_RS09490	COG0583	DNA-binding transcription factor activity
C2D63_RS09505	COG3122	Protein conserved in bacteria
C2D63_RS09525	COG2885	chlorophyll binding
C2D63_RS09545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2D63_RS09555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2D63_RS09620	COG0012	GTP binding
C2D63_RS09640	COG0659	secondary active sulfate transmembrane transporter activity
C2D63_RS09670	COG2890	protein-(glutamine-N5) methyltransferase activity
C2D63_RS09690	COG0387	Pfam Sodium calcium exchanger
C2D63_RS09695	COG4572	Cation transport regulator
C2D63_RS09700	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2D63_RS09710	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2D63_RS09715	COG3707	response regulator
C2D63_RS09720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D63_RS09730	COG1116	anion transmembrane transporter activity
C2D63_RS09735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2D63_RS09735	COG2146	nitrite reductase [NAD(P)H] activity
C2D63_RS09740	COG0243	molybdopterin cofactor binding
C2D63_RS09745	COG4932	domain protein
C2D63_RS09750	COG2197	response regulator
C2D63_RS09755	COG3850	Histidine kinase
C2D63_RS09760	COG2223	nitrite transmembrane transporter activity
C2D63_RS09765	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2D63_RS09770	COG1140	nitrate reductase beta subunit
C2D63_RS09775	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2D63_RS09780	COG2181	nitrate reductase activity
C2D63_RS09790	COG1522	sequence-specific DNA binding
C2D63_RS09825	COG0788	formyltetrahydrofolate deformylase activity
C2D63_RS09835	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2D63_RS09840	COG0745	RESPONSE REGULATOR receiver
C2D63_RS09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2D63_RS09850	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D63_RS09855	COG1435	thymidine kinase activity
C2D63_RS09860	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS09860	COG1454	alcohol dehydrogenase
C2D63_RS09865	COG2095	MarC family integral membrane protein
C2D63_RS09870	COG4166	transmembrane transport
C2D63_RS09875	COG0601	transmembrane transport
C2D63_RS09880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS09885	COG0444	Belongs to the ABC transporter superfamily
C2D63_RS09895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2D63_RS09915	COG2353	YceI-like domain
C2D63_RS09920	COG2350	Protein conserved in bacteria
C2D63_RS09930	COG3001	Fructosamine kinase
C2D63_RS09940	COG1105	Belongs to the carbohydrate kinase PfkB family
C2D63_RS09945	COG3137	Salt-induced outer membrane protein
C2D63_RS09985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2D63_RS09985	COG0072	phenylalanine-tRNA ligase activity
C2D63_RS10005	COG0583	DNA-binding transcription factor activity
C2D63_RS10025	COG0386	Belongs to the glutathione peroxidase family
C2D63_RS10035	COG0791	NLP P60 protein
C2D63_RS10045	COG4256	Hemin uptake protein
C2D63_RS10050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D63_RS10060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2D63_RS10060	COG0574	Belongs to the PEP-utilizing enzyme family
C2D63_RS10070	COG0628	permease
C2D63_RS10075	COG0277	FAD linked oxidase domain protein
C2D63_RS10075	COG0247	lactate metabolic process
C2D63_RS10080	COG2050	protein possibly involved in aromatic compounds catabolism
C2D63_RS10085	COG2261	transglycosylase associated protein
C2D63_RS10110	COG1120	ATPase activity
C2D63_RS10115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS10125	COG0583	DNA-binding transcription factor activity
C2D63_RS10150	COG1304	FMN binding
C2D63_RS10155	COG1309	transcriptional regulator
C2D63_RS10170	COG0316	Belongs to the HesB IscA family
C2D63_RS10175	COG0719	Fe-S assembly protein
C2D63_RS10180	COG0396	ATPase activity
C2D63_RS10185	COG0719	Fe-S assembly protein
C2D63_RS10200	COG1376	ErfK ybiS ycfS ynhG family protein
C2D63_RS10225	COG1309	transcriptional regulator
C2D63_RS10230	COG1082	Xylose isomerase domain protein TIM barrel
C2D63_RS10230	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2D63_RS10235	COG2271	Major facilitator Superfamily
C2D63_RS10240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2D63_RS10250	COG1120	ATPase activity
C2D63_RS10255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS10260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2D63_RS10265	COG1414	Transcriptional regulator
C2D63_RS10300	COG2814	Major facilitator Superfamily
C2D63_RS10320	COG0583	DNA-binding transcription factor activity
C2D63_RS10325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D63_RS10350	COG1116	anion transmembrane transporter activity
C2D63_RS10355	COG4774	siderophore transport
C2D63_RS10360	COG1120	ATPase activity
C2D63_RS10365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS10370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS10390	COG0765	amino acid transport
C2D63_RS10395	COG1126	abc transporter atp-binding protein
C2D63_RS10425	COG1473	amidohydrolase
C2D63_RS10430	COG3383	formate dehydrogenase (NAD+) activity
C2D63_RS10435	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2D63_RS10445	COG1175	transmembrane transport
C2D63_RS10475	COG1857	crispr-associated protein
C2D63_RS10485	COG1518	maintenance of DNA repeat elements
C2D63_RS10490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D63_RS10495	COG3157	Type VI secretion system effector, Hcp
C2D63_RS10525	COG4133	protoheme IX ABC transporter activity
C2D63_RS10530	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2D63_RS10535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2D63_RS10550	COG1138	Cytochrome C-type biogenesis protein
C2D63_RS10555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2D63_RS10560	COG3088	subunit of a heme lyase
C2D63_RS10560	COG4235	cytochrome complex assembly
C2D63_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS10615	COG2610	gluconate transmembrane transporter activity
C2D63_RS10620	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2D63_RS10630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2D63_RS10640	COG0583	DNA-binding transcription factor activity
C2D63_RS10665	COG0277	FAD linked oxidase domain protein
C2D63_RS10670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D63_RS10700	COG0402	S-adenosylhomocysteine deaminase activity
C2D63_RS10755	COG4608	Belongs to the ABC transporter superfamily
C2D63_RS10760	COG0444	Belongs to the ABC transporter superfamily
C2D63_RS10785	COG0346	lactoylglutathione lyase activity
C2D63_RS10790	COG1349	DNA-binding transcription factor activity
C2D63_RS10820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2D63_RS10840	COG0300	oxidoreductase activity
C2D63_RS10885	COG0307	riboflavin synthase, alpha
C2D63_RS10890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2D63_RS10895	COG2814	Major facilitator Superfamily
C2D63_RS10900	COG0583	DNA-binding transcription factor activity
C2D63_RS10915	COG2814	Major facilitator Superfamily
C2D63_RS10930	COG0791	NLP P60 protein
C2D63_RS10935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2D63_RS10945	COG0346	lactoylglutathione lyase activity
C2D63_RS10950	COG1902	pentaerythritol trinitrate reductase activity
C2D63_RS10955	COG1309	transcriptional regulator
C2D63_RS10960	COG3313	Fe-S protein
C2D63_RS10965	COG4989	oxidoreductase activity
C2D63_RS10970	COG2032	superoxide dismutase activity
C2D63_RS10975	COG1289	transmembrane transporter activity
C2D63_RS10980	COG1566	PFAM secretion protein HlyD family protein
C2D63_RS10995	COG3706	GGDEF domain
C2D63_RS11010	COG3895	Periplasmic Protein
C2D63_RS11025	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2D63_RS11030	COG0625	glutathione transferase activity
C2D63_RS11040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2D63_RS11050	COG4659	FMN binding
C2D63_RS11090	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS11100	COG0673	inositol 2-dehydrogenase activity
C2D63_RS11110	COG2814	Major facilitator Superfamily
C2D63_RS11130	COG3038	cytochrome b561
C2D63_RS11150	COG0583	DNA-binding transcription factor activity
C2D63_RS11155	COG3485	protocatechuate 3,4-dioxygenase
C2D63_RS11160	COG3485	protocatechuate 3,4-dioxygenase
C2D63_RS11165	COG5383	Protein conserved in bacteria
C2D63_RS11170	COG2272	Belongs to the type-B carboxylesterase lipase family
C2D63_RS11185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D63_RS11190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D63_RS11195	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2D63_RS11200	COG0500	methyltransferase
C2D63_RS11210	COG0697	spore germination
C2D63_RS11215	COG3708	Transcriptional regulator
C2D63_RS11215	COG2207	Transcriptional regulator
C2D63_RS11220	COG3135	benzoate transporter
C2D63_RS11225	COG1396	sequence-specific DNA binding
C2D63_RS11235	COG0826	peptidase U32
C2D63_RS11255	COG1294	oxidase, subunit
C2D63_RS11260	COG1271	oxidase subunit
C2D63_RS11265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D63_RS11270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2D63_RS11275	COG3842	ATPase activity
C2D63_RS11280	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2D63_RS11285	COG1177	transmembrane transport
C2D63_RS11290	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS11330	COG0747	negative chemotaxis
C2D63_RS11340	COG3238	Protein conserved in bacteria
C2D63_RS11345	COG1247	-acetyltransferase
C2D63_RS11355	COG2130	NADP-dependent
C2D63_RS11365	COG3691	Protein conserved in bacteria
C2D63_RS11370	COG1228	amidohydrolase
C2D63_RS11375	COG4772	TonB-dependent receptor
C2D63_RS11400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2D63_RS11405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D63_RS11410	COG1473	amidohydrolase
C2D63_RS11415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D63_RS11420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS11430	COG0765	amino acid transport
C2D63_RS11435	COG1126	abc transporter atp-binding protein
C2D63_RS11445	COG0625	glutathione transferase activity
C2D63_RS11455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D63_RS11460	COG3842	ATPase activity
C2D63_RS11465	COG1840	ABC-type Fe3 transport system, periplasmic component
C2D63_RS11470	COG1178	ABC-type Fe3 transport system permease component
C2D63_RS11475	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2D63_RS11480	COG2181	nitrate reductase activity
C2D63_RS11485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2D63_RS11490	COG1140	nitrate reductase beta subunit
C2D63_RS11495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2D63_RS11500	COG2223	nitrite transmembrane transporter activity
C2D63_RS11515	COG1414	Transcriptional regulator
C2D63_RS11520	COG4948	Mandelate Racemase Muconate Lactonizing
C2D63_RS11525	COG4829	muconolactone delta-isomerase
C2D63_RS11530	COG3485	protocatechuate 3,4-dioxygenase
C2D63_RS11540	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2D63_RS11565	COG0437	4 iron, 4 sulfur cluster binding
C2D63_RS11570	COG2864	formate dehydrogenase
C2D63_RS11585	COG2326	polyphosphate kinase activity
C2D63_RS11595	COG2814	Major facilitator Superfamily
C2D63_RS11605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D63_RS11615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS11625	COG0747	negative chemotaxis
C2D63_RS11630	COG1064	alcohol dehydrogenase
C2D63_RS11645	COG0488	(ABC) transporter
C2D63_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS11685	COG3729	General stress protein
C2D63_RS11695	COG3685	Protein conserved in bacteria
C2D63_RS11705	COG0366	Alpha amylase catalytic
C2D63_RS11715	COG2323	membrane
C2D63_RS11725	COG3111	PFAM Bacterial OB fold (BOF) protein
C2D63_RS11730	COG1764	response to oxidative stress
C2D63_RS11750	COG3781	membrane
C2D63_RS11755	COG0243	molybdopterin cofactor binding
C2D63_RS11760	COG0583	DNA-binding transcription factor activity
C2D63_RS11765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS11795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS11800	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D63_RS11805	COG2814	Major facilitator Superfamily
C2D63_RS11810	COG1285	pathogenesis
C2D63_RS11815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2D63_RS11825	COG0583	DNA-binding transcription factor activity
C2D63_RS11845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2D63_RS11845	COG0519	Catalyzes the synthesis of GMP from XMP
C2D63_RS11885	COG0596	Alpha beta hydrolase
C2D63_RS11895	COG2205	protein histidine kinase activity
C2D63_RS11910	COG0076	glutamate decarboxylase activity
C2D63_RS11915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D63_RS11920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D63_RS11925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D63_RS11930	COG1116	anion transmembrane transporter activity
C2D63_RS11935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2D63_RS11945	COG0673	inositol 2-dehydrogenase activity
C2D63_RS11955	COG1609	Transcriptional regulator
C2D63_RS11960	COG3706	GGDEF domain
C2D63_RS11965	COG0402	S-adenosylhomocysteine deaminase activity
C2D63_RS11970	COG1953	Uracil, thiamine, allantoin
C2D63_RS12005	COG0596	Alpha beta hydrolase
C2D63_RS12015	COG2207	Transcriptional regulator
C2D63_RS12030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D63_RS12050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2D63_RS12095	COG0765	amino acid transport
C2D63_RS12105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2D63_RS12115	COG2070	2-Nitropropane dioxygenase
C2D63_RS12120	COG0583	DNA-binding transcription factor activity
C2D63_RS12130	COG1902	pentaerythritol trinitrate reductase activity
C2D63_RS12135	COG4529	Protein conserved in bacteria
C2D63_RS12140	COG0477	Major facilitator Superfamily
C2D63_RS12170	COG2223	nitrite transmembrane transporter activity
C2D63_RS12180	COG1609	Transcriptional regulator
C2D63_RS12185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS12195	COG3037	sugar-specific permease SgaT UlaA
C2D63_RS12200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D63_RS12210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS12230	COG0583	DNA-binding transcription factor activity
C2D63_RS12235	COG0583	DNA-binding transcription factor activity
C2D63_RS12240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2D63_RS12250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2D63_RS12265	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS12275	COG1609	Transcriptional regulator
C2D63_RS12305	COG1652	LysM domain
C2D63_RS12330	COG0456	acetyltransferase
C2D63_RS12330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2D63_RS12360	COG1349	DNA-binding transcription factor activity
C2D63_RS12375	COG1349	DNA-binding transcription factor activity
C2D63_RS12380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2D63_RS12385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D63_RS12390	COG0738	Major facilitator superfamily
C2D63_RS12435	COG1929	Belongs to the glycerate kinase type-1 family
C2D63_RS12440	COG3835	regulator
C2D63_RS12460	COG2186	Transcriptional regulator
C2D63_RS12465	COG1263	PTS System
C2D63_RS12465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS12475	COG2814	Major facilitator Superfamily
C2D63_RS12480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS12480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS12490	COG2819	hydrolase of the alpha beta superfamily
C2D63_RS12495	COG5001	Diguanylate cyclase
C2D63_RS12495	COG3300	MHYT domain
C2D63_RS12530	COG3188	usher protein
C2D63_RS12540	COG1649	PFAM Uncharacterised BCR, COG1649
C2D63_RS12545	COG3550	peptidyl-serine autophosphorylation
C2D63_RS12550	COG1396	sequence-specific DNA binding
C2D63_RS12555	COG2351	hydroxyisourate hydrolase activity
C2D63_RS12560	COG3195	allantoin biosynthetic process
C2D63_RS12560	COG3648	Uricase
C2D63_RS12565	COG2233	PERMEase
C2D63_RS12595	COG2207	Transcriptional regulator
C2D63_RS12630	COG2011	ABC-type metal ion transport system permease component
C2D63_RS12635	COG2070	2-Nitropropane dioxygenase
C2D63_RS12645	COG0477	Major facilitator Superfamily
C2D63_RS12720	COG2199	diguanylate cyclase activity
C2D63_RS12735	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS12740	COG0583	DNA-binding transcription factor activity
C2D63_RS12750	COG0039	L-malate dehydrogenase activity
C2D63_RS12755	COG1349	DNA-binding transcription factor activity
C2D63_RS12760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2D63_RS12765	COG3395	kinase activity
C2D63_RS12775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2D63_RS12780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D63_RS12785	COG2271	Major facilitator Superfamily
C2D63_RS12810	COG4977	sequence-specific DNA binding
C2D63_RS12820	COG0697	spore germination
C2D63_RS12825	COG2814	Major facilitator Superfamily
C2D63_RS12860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2D63_RS12895	COG2223	nitrite transmembrane transporter activity
C2D63_RS12900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2D63_RS12915	COG1349	DNA-binding transcription factor activity
C2D63_RS12920	COG2084	Dehydrogenase
C2D63_RS12925	COG3395	kinase activity
C2D63_RS12930	COG0235	Class ii aldolase
C2D63_RS12935	COG3622	Belongs to the hyi family
C2D63_RS12940	COG2610	gluconate transmembrane transporter activity
C2D63_RS12945	COG3708	Transcriptional regulator
C2D63_RS12945	COG2207	Transcriptional regulator
C2D63_RS12960	COG2200	EAL domain
C2D63_RS12965	COG1546	Belongs to the CinA family
C2D63_RS12970	COG0071	Belongs to the small heat shock protein (HSP20) family
C2D63_RS12975	COG2197	response regulator
C2D63_RS12985	COG2135	peptidase activity
C2D63_RS12990	COG2207	Transcriptional regulator
C2D63_RS13005	COG4221	oxidoreductase activity
C2D63_RS13010	COG1802	Transcriptional regulator
C2D63_RS13015	COG0589	response to stress
C2D63_RS13020	COG0246	Mannitol dehydrogenase
C2D63_RS13025	COG2271	Major facilitator Superfamily
C2D63_RS13040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D63_RS13055	COG0243	molybdopterin cofactor binding
C2D63_RS13060	COG0437	4 iron, 4 sulfur cluster binding
C2D63_RS13065	COG3302	dmso reductase anchor subunit
C2D63_RS13080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2D63_RS13085	COG1940	carbohydrate kinase activity
C2D63_RS13090	COG0583	DNA-binding transcription factor activity
C2D63_RS13095	COG2814	Major facilitator Superfamily
C2D63_RS13100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2D63_RS13110	COG3591	Belongs to the peptidase S1B family
C2D63_RS13130	COG0628	permease
C2D63_RS13160	COG0679	Auxin Efflux Carrier
C2D63_RS13170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2D63_RS13195	COG3290	protein histidine kinase activity
C2D63_RS13200	COG4565	transcriptional regulatory protein
C2D63_RS13220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D63_RS13220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D63_RS13230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D63_RS13235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2D63_RS13245	COG0183	Belongs to the thiolase family
C2D63_RS13250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2D63_RS13260	COG1414	Transcriptional regulator
C2D63_RS13265	COG2840	Smr protein MutS2
C2D63_RS13270	COG0583	DNA-binding transcription factor activity
C2D63_RS13280	COG1473	amidohydrolase
C2D63_RS13285	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2D63_RS13300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2D63_RS13315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2D63_RS13320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2D63_RS13330	COG0531	amino acid
C2D63_RS13340	COG3136	membrane protein required for alginate biosynthesis
C2D63_RS13345	COG0745	RESPONSE REGULATOR receiver
C2D63_RS13355	COG2205	protein histidine kinase activity
C2D63_RS13365	COG0114	fumarate hydratase activity
C2D63_RS13370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D63_RS13370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2D63_RS13375	COG1482	cell wall glycoprotein biosynthetic process
C2D63_RS13380	COG5339	Protein conserved in bacteria
C2D63_RS13385	COG1609	Transcriptional regulator
C2D63_RS13390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS13390	COG1263	PTS System
C2D63_RS13395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2D63_RS13420	COG2391	methyltransferase activity
C2D63_RS13425	COG0425	Belongs to the sulfur carrier protein TusA family
C2D63_RS13430	COG5562	phage envelope protein
C2D63_RS13435	COG0401	homolog of Blt101
C2D63_RS13440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2D63_RS13445	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS13450	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2D63_RS13455	COG0477	Major facilitator Superfamily
C2D63_RS13460	COG1113	amino acid transport
C2D63_RS13465	COG2988	succinylglutamate desuccinylase activity
C2D63_RS13470	COG3724	N-succinylarginine dihydrolase activity
C2D63_RS13475	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS13480	COG3138	arginine N-succinyltransferase
C2D63_RS13485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2D63_RS13490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2D63_RS13495	COG0667	Aldo Keto reductase
C2D63_RS13500	COG0583	DNA-binding transcription factor activity
C2D63_RS13525	COG4122	O-methyltransferase activity
C2D63_RS13530	COG1643	Atp-dependent helicase
C2D63_RS13545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2D63_RS13550	COG3327	negative regulation of DNA-templated transcription, initiation
C2D63_RS13555	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2D63_RS13560	COG0183	Belongs to the thiolase family
C2D63_RS13565	COG2050	protein possibly involved in aromatic compounds catabolism
C2D63_RS13570	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2D63_RS13575	COG1024	Enoyl-CoA hydratase
C2D63_RS13580	COG1024	Enoyl-CoA hydratase
C2D63_RS13585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D63_RS13590	COG2151	metal-sulfur cluster biosynthetic enzyme
C2D63_RS13595	COG3396	Phenylacetate-CoA oxygenase
C2D63_RS13600	COG3460	Phenylacetate-CoA oxygenase
C2D63_RS13605	COG3396	Phenylacetate-CoA oxygenase
C2D63_RS13610	COG2030	dehydratase
C2D63_RS13610	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS13630	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS13635	COG2207	Transcriptional regulator
C2D63_RS13640	COG3784	Protein of unknown function (DUF1318)
C2D63_RS13650	COG2911	Protein conserved in bacteria
C2D63_RS13655	COG0586	Pfam SNARE associated Golgi protein
C2D63_RS13660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2D63_RS13665	COG3187	Heat shock protein
C2D63_RS13670	COG3042	response to heat
C2D63_RS13675	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2D63_RS13675	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2D63_RS13675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2D63_RS13675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2D63_RS13680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D63_RS13690	COG0589	response to stress
C2D63_RS13700	COG0513	Belongs to the DEAD box helicase family
C2D63_RS13710	COG1349	DNA-binding transcription factor activity
C2D63_RS13715	COG0673	inositol 2-dehydrogenase activity
C2D63_RS13730	COG1113	amino acid transport
C2D63_RS13735	COG1522	sequence-specific DNA binding
C2D63_RS13745	COG1448	Aminotransferase
C2D63_RS13750	COG2011	ABC-type metal ion transport system permease component
C2D63_RS13765	COG0436	Aminotransferase
C2D63_RS13770	COG0604	alcohol dehydrogenase
C2D63_RS13795	COG0583	DNA-binding transcription factor activity
C2D63_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS13820	COG1309	transcriptional regulator
C2D63_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS13895	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2D63_RS13895	COG1388	LysM domain
C2D63_RS13920	COG2885	chlorophyll binding
C2D63_RS13945	COG0693	protein deglycase activity
C2D63_RS13950	COG1078	dGTPase activity
C2D63_RS13955	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS13960	COG0583	DNA-binding transcription factor activity
C2D63_RS14020	COG5002	protein histidine kinase activity
C2D63_RS14020	COG2205	protein histidine kinase activity
C2D63_RS14020	COG0784	Response regulator, receiver
C2D63_RS14025	COG3250	beta-galactosidase activity
C2D63_RS14030	COG0656	L-ascorbic acid biosynthetic process
C2D63_RS14095	COG4166	transmembrane transport
C2D63_RS14100	COG2866	Carboxypeptidase
C2D63_RS14105	COG4948	Mandelate Racemase Muconate Lactonizing
C2D63_RS14110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2D63_RS14115	COG3180	Ammonia monooxygenase
C2D63_RS14125	COG1486	melibiose metabolic process
C2D63_RS14130	COG0583	DNA-binding transcription factor activity
C2D63_RS14140	COG3106	COG3106 Predicted ATPase
C2D63_RS14150	COG1983	PspC domain protein
C2D63_RS14160	COG1842	Phage shock protein A
C2D63_RS14165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D63_RS14175	COG1473	amidohydrolase
C2D63_RS14190	COG0702	epimerase
C2D63_RS14205	COG4171	peptide transport system, permease
C2D63_RS14220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2D63_RS14230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2D63_RS14235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D63_RS14235	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D63_RS14250	COG1349	DNA-binding transcription factor activity
C2D63_RS14260	COG0023	Translation Initiation Factor
C2D63_RS14270	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2D63_RS14275	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2D63_RS14280	COG0671	phosphoesterase, PA-phosphatase related
C2D63_RS14290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2D63_RS14315	COG0616	signal peptide processing
C2D63_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS14330	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C2D63_RS14340	COG0583	DNA-binding transcription factor activity
C2D63_RS14350	COG0009	L-threonylcarbamoyladenylate synthase
C2D63_RS14360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2D63_RS14365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2D63_RS14365	COG0512	Glutamine amidotransferase of anthranilate synthase
C2D63_RS14370	COG0135	phosphoribosylanthranilate isomerase activity
C2D63_RS14370	COG0134	indole-3-glycerol-phosphate synthase activity
C2D63_RS14425	COG4774	siderophore transport
C2D63_RS14435	COG3047	cAMP biosynthetic process
C2D63_RS14440	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2D63_RS14470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D63_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS14480	COG1988	membrane-bound metal-dependent
C2D63_RS14485	COG1823	symporter activity
C2D63_RS14505	COG1486	melibiose metabolic process
C2D63_RS14510	COG1917	Cupin 2, conserved barrel domain protein
C2D63_RS14510	COG2169	Transcriptional regulator
C2D63_RS14515	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D63_RS14520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS14525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS14530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D63_RS14540	COG0322	excinuclease ABC activity
C2D63_RS14545	COG3678	ATP-independent chaperone mediated protein folding
C2D63_RS14555	COG3724	N-succinylarginine dihydrolase activity
C2D63_RS14565	COG3138	arginine N-succinyltransferase
C2D63_RS14575	COG0708	Exodeoxyribonuclease III
C2D63_RS14580	COG0398	Pfam SNARE associated Golgi protein
C2D63_RS14585	COG0398	Pfam SNARE associated Golgi protein
C2D63_RS14590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2D63_RS14595	COG4134	Bacterial extracellular solute-binding protein
C2D63_RS14600	COG4135	transport system, permease component
C2D63_RS14605	COG4136	ATPase activity
C2D63_RS14610	COG2897	thiosulfate sulfurtransferase activity
C2D63_RS14615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2D63_RS14620	COG0494	nUDIX hydrolase
C2D63_RS14625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2D63_RS14630	COG3321	synthase
C2D63_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS14630	COG0604	alcohol dehydrogenase
C2D63_RS14635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2D63_RS14640	COG0709	Synthesizes selenophosphate from selenide and ATP
C2D63_RS14650	COG0778	Nitroreductase
C2D63_RS14655	COG0616	signal peptide processing
C2D63_RS14660	COG0252	asparaginase activity
C2D63_RS14680	COG3139	Protein of unknown function (DUF1315)
C2D63_RS14700	COG0656	L-ascorbic acid biosynthetic process
C2D63_RS14705	COG3713	MltA-interacting MipA family protein
C2D63_RS14710	COG2766	serine protein kinase
C2D63_RS14725	COG0386	Belongs to the glutathione peroxidase family
C2D63_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS14750	COG0583	DNA-binding transcription factor activity
C2D63_RS14755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2D63_RS14760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2D63_RS14770	COG0859	PFAM glycosyl transferase family 9
C2D63_RS14775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D63_RS14785	COG2207	Transcriptional regulator
C2D63_RS14790	COG2807	transmembrane transport
C2D63_RS14795	COG0504	CTP synthase activity
C2D63_RS14800	COG1683	Conserved Protein
C2D63_RS14805	COG3189	MarR family transcriptional regulator
C2D63_RS14810	COG3042	response to heat
C2D63_RS14815	COG2199	diguanylate cyclase activity
C2D63_RS14815	COG2203	Gaf domain
C2D63_RS14835	COG3182	Iron-regulated membrane protein
C2D63_RS14845	COG1560	Kdo2-lipid A biosynthetic process
C2D63_RS14870	COG3179	chitinase
C2D63_RS14895	COG0484	heat shock protein binding
C2D63_RS14900	COG1403	HNH endonuclease
C2D63_RS14915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2D63_RS14925	COG4725	Belongs to the MT-A70-like family
C2D63_RS14935	COG1802	Transcriptional regulator
C2D63_RS14935	COG4626	Terminase
C2D63_RS14980	COG5532	Uncharacterized conserved protein (DUF2303)
C2D63_RS14985	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2D63_RS15015	COG0582	viral genome integration into host DNA
C2D63_RS15020	COG0538	isocitrate dehydrogenase activity
C2D63_RS15025	COG1187	pseudouridine synthase activity
C2D63_RS15045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2D63_RS15065	COG2205	protein histidine kinase activity
C2D63_RS15070	COG2850	peptidyl-arginine hydroxylation
C2D63_RS15075	COG1943	Transposase
C2D63_RS15100	COG1177	transmembrane transport
C2D63_RS15115	COG0318	PFAM AMP-dependent synthetase and ligase
C2D63_RS15120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2D63_RS15125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D63_RS15130	COG0698	ribose 5-phosphate isomerase
C2D63_RS15145	COG3395	kinase activity
C2D63_RS15160	COG2390	Transcriptional regulator
C2D63_RS15170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2D63_RS15180	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2D63_RS15190	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2D63_RS15195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2D63_RS15200	COG1388	LysM domain
C2D63_RS15200	COG1376	ErfK ybiS ycfS ynhG family protein
C2D63_RS15210	COG1309	transcriptional regulator
C2D63_RS15220	COG3134	Outer membrane lipoprotein
C2D63_RS15225	COG1252	NADH dehydrogenase
C2D63_RS15250	COG5633	Lipoprotein
C2D63_RS15255	COG0537	adenosine 5'-monophosphoramidase activity
C2D63_RS15265	COG0084	hydrolase, TatD family'
C2D63_RS15270	COG0470	DNA polymerase III
C2D63_RS15280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2D63_RS15285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2D63_RS15290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2D63_RS15305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2D63_RS15325	COG1399	metal-binding, possibly nucleic acid-binding protein
C2D63_RS15340	COG1530	ribonuclease E activity
C2D63_RS15345	COG0583	DNA-binding transcription factor activity
C2D63_RS15350	COG2814	Major facilitator Superfamily
C2D63_RS15370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2D63_RS15415	COG1560	Kdo2-lipid A biosynthetic process
C2D63_RS15430	COG5645	(Lipo)protein
C2D63_RS15465	COG3381	protein complex oligomerization
C2D63_RS15485	COG0583	DNA-binding transcription factor activity
C2D63_RS15495	COG1335	isochorismatase
C2D63_RS15505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2D63_RS15510	COG1702	phosphate starvation-inducible protein PhoH
C2D63_RS15530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D63_RS15540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2D63_RS15555	COG1309	transcriptional regulator
C2D63_RS15590	COG2233	PERMEase
C2D63_RS15600	COG3729	General stress protein
C2D63_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS15640	COG0531	amino acid
C2D63_RS15645	COG0174	glutamine synthetase
C2D63_RS15650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2D63_RS15655	COG1396	sequence-specific DNA binding
C2D63_RS15655	COG1917	Cupin 2, conserved barrel domain protein
C2D63_RS15660	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS15665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2D63_RS15670	COG0583	DNA-binding transcription factor activity
C2D63_RS15675	COG0473	3-isopropylmalate dehydrogenase activity
C2D63_RS15680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2D63_RS15685	COG4638	Rieske (2fe-2S)
C2D63_RS15690	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS15695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D63_RS15700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS15700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2D63_RS15700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS15705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS15710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS15715	COG1882	Formate acetyltransferase
C2D63_RS15720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D63_RS15725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2D63_RS15735	COG2207	Transcriptional regulator
C2D63_RS15740	COG3706	GGDEF domain
C2D63_RS15760	COG2200	EAL domain
C2D63_RS15770	COG0058	SHG alpha-glucan phosphorylase activity
C2D63_RS15785	COG0670	Belongs to the BI1 family
C2D63_RS15800	COG2207	Transcriptional regulator
C2D63_RS15805	COG1881	PFAM PEBP family protein
C2D63_RS15820	COG1832	CoA-binding protein
C2D63_RS15830	COG0210	DNA helicase
C2D63_RS15835	COG3304	Inner membrane component domain
C2D63_RS15840	COG1289	transmembrane transporter activity
C2D63_RS15845	COG3070	regulator of competence-specific genes
C2D63_RS15870	COG1067	ATP-dependent peptidase activity
C2D63_RS15880	COG3130	regulation of translation
C2D63_RS15885	COG3009	Protein conserved in bacteria
C2D63_RS15890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2D63_RS15890	COG3008	intermembrane lipid transfer
C2D63_RS15895	COG2995	paraquat-inducible protein a
C2D63_RS15900	COG0488	(ABC) transporter
C2D63_RS15910	COG0633	Ferredoxin
C2D63_RS15910	COG3217	Mosc domain protein beta barrel domain protein
C2D63_RS15925	COG0431	NADPH-dependent FMN reductase
C2D63_RS15930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2D63_RS15935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2D63_RS15940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D63_RS15950	COG0308	aminopeptidase N
C2D63_RS15960	COG1473	amidohydrolase
C2D63_RS15970	COG0814	amino acid
C2D63_RS15980	COG1522	sequence-specific DNA binding
C2D63_RS15990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2D63_RS15995	COG1448	Aminotransferase
C2D63_RS16000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2D63_RS16005	COG3108	Peptidase M15
C2D63_RS16010	COG2989	Protein conserved in bacteria
C2D63_RS16020	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2D63_RS16030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2D63_RS16035	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2D63_RS16040	COG3173	Aminoglycoside phosphotransferase
C2D63_RS16055	COG3214	Protein conserved in bacteria
C2D63_RS16070	COG0658	competence protein
C2D63_RS16070	COG2333	competence protein COMEC
C2D63_RS16080	COG0539	negative regulation of cytoplasmic translation
C2D63_RS16100	COG2323	membrane
C2D63_RS16105	COG1944	ATP diphosphatase activity
C2D63_RS16110	COG2116	formate transmembrane transporter activity
C2D63_RS16115	COG1882	Formate acetyltransferase
C2D63_RS16120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D63_RS16125	COG0477	Major facilitator Superfamily
C2D63_RS16135	COG3302	dmso reductase anchor subunit
C2D63_RS16140	COG0437	4 iron, 4 sulfur cluster binding
C2D63_RS16145	COG0243	molybdopterin cofactor binding
C2D63_RS16155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2D63_RS16165	COG1178	ABC-type Fe3 transport system permease component
C2D63_RS16165	COG1674	ftsk spoiiie
C2D63_RS16175	COG0492	ferredoxin-NADP+ reductase activity
C2D63_RS16180	COG4988	ABC transporter
C2D63_RS16185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2D63_RS16200	COG0542	response to heat
C2D63_RS16210	COG1278	Cold shock
C2D63_RS16220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS16225	COG3593	DNA synthesis involved in DNA repair
C2D63_RS16235	COG2431	L-lysine efflux transmembrane transporter activity
C2D63_RS16245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2D63_RS16255	COG0028	Belongs to the TPP enzyme family
C2D63_RS16260	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2D63_RS16265	COG0702	epimerase
C2D63_RS16270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2D63_RS16275	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2D63_RS16280	COG4251	negative regulation of phosphorylation
C2D63_RS16280	COG2203	Gaf domain
C2D63_RS16280	COG5001	Diguanylate cyclase
C2D63_RS16280	COG3706	GGDEF domain
C2D63_RS16290	COG1126	abc transporter atp-binding protein
C2D63_RS16295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS16300	COG4215	(ABC) transporter
C2D63_RS16305	COG4160	amino acid transport
C2D63_RS16310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS16315	COG5002	protein histidine kinase activity
C2D63_RS16320	COG0745	RESPONSE REGULATOR receiver
C2D63_RS16335	COG1177	transmembrane transport
C2D63_RS16340	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2D63_RS16345	COG3842	ATPase activity
C2D63_RS16350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2D63_RS16365	COG0778	Nitroreductase
C2D63_RS16390	COG3226	Transcriptional regulator
C2D63_RS16395	COG0738	Major facilitator superfamily
C2D63_RS16400	COG0561	phosphatase activity
C2D63_RS16405	COG2814	Major facilitator Superfamily
C2D63_RS16410	COG0671	phosphoesterase, PA-phosphatase related
C2D63_RS16415	COG1349	DNA-binding transcription factor activity
C2D63_RS16420	COG1686	Belongs to the peptidase S11 family
C2D63_RS16425	COG0625	glutathione transferase activity
C2D63_RS16430	COG2133	pyrroloquinoline quinone binding
C2D63_RS16440	COG2223	nitrite transmembrane transporter activity
C2D63_RS16460	COG0747	negative chemotaxis
C2D63_RS16475	COG0303	'Molybdopterin
C2D63_RS16480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2D63_RS16485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2D63_RS16490	COG1882	Formate acetyltransferase
C2D63_RS16495	COG0561	phosphatase activity
C2D63_RS16505	COG1609	Transcriptional regulator
C2D63_RS16510	COG2271	Major facilitator Superfamily
C2D63_RS16520	COG0488	(ABC) transporter
C2D63_RS16525	COG2365	Tyrosine phosphatase family
C2D63_RS16530	COG1376	ErfK ybiS ycfS ynhG family protein
C2D63_RS16535	COG2188	Transcriptional regulator
C2D63_RS16540	COG2723	6-phospho-beta-galactosidase activity
C2D63_RS16545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2D63_RS16560	COG2194	sulfuric ester hydrolase activity
C2D63_RS16565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2D63_RS16580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS16585	COG0765	amino acid transport
C2D63_RS16590	COG1126	abc transporter atp-binding protein
C2D63_RS16595	COG0668	transmembrane transport
C2D63_RS16605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D63_RS16615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2D63_RS16625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2D63_RS16630	COG1199	ATP-dependent helicase activity
C2D63_RS16635	COG0513	Belongs to the DEAD box helicase family
C2D63_RS16640	COG3958	Transketolase
C2D63_RS16645	COG3959	Transketolase, thiamine diphosphate binding domain
C2D63_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS16655	COG2271	Major facilitator Superfamily
C2D63_RS16660	COG0583	DNA-binding transcription factor activity
C2D63_RS16665	COG1309	transcriptional regulator
C2D63_RS16670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS16675	COG1131	(ABC) transporter
C2D63_RS16680	COG0842	Transport permease protein
C2D63_RS16685	COG0842	Transport permease protein
C2D63_RS16695	COG3568	Endonuclease Exonuclease Phosphatase
C2D63_RS16700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2D63_RS16705	COG0392	lysyltransferase activity
C2D63_RS16710	COG0670	Belongs to the BI1 family
C2D63_RS16715	COG0314	molybdopterin synthase activity
C2D63_RS16720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2D63_RS16730	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2D63_RS16750	COG0745	RESPONSE REGULATOR receiver
C2D63_RS16755	COG0642	Histidine kinase
C2D63_RS16785	COG2226	methyltransferase
C2D63_RS16800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2D63_RS16805	COG1881	PFAM PEBP family protein
C2D63_RS16840	COG4677	pectinesterase activity
C2D63_RS16850	COG0589	response to stress
C2D63_RS16855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS16890	COG0789	Transcriptional regulator
C2D63_RS16895	COG2200	EAL domain
C2D63_RS16920	COG0561	phosphatase activity
C2D63_RS16925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2D63_RS16930	COG4149	molybdate abc transporter
C2D63_RS16935	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2D63_RS16945	COG2005	Transcriptional regulator
C2D63_RS16945	COG3585	molybdate ion transport
C2D63_RS16950	COG1119	ATPase activity
C2D63_RS16960	COG1085	galactose-1-phosphate uridylyltransferase
C2D63_RS16970	COG2017	converts alpha-aldose to the beta-anomer
C2D63_RS16980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2D63_RS16995	COG3201	nicotinamide mononucleotide transporter
C2D63_RS17000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2D63_RS17050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2D63_RS17055	COG2885	chlorophyll binding
C2D63_RS17065	COG3064	Membrane
C2D63_RS17070	COG0848	biopolymer transport protein
C2D63_RS17075	COG0811	peptide transport
C2D63_RS17080	COG0824	Thioesterase
C2D63_RS17085	COG3790	cyd operon protein YbgE
C2D63_RS17090	COG4890	Cyd operon protein YbgT
C2D63_RS17095	COG1294	oxidase, subunit
C2D63_RS17100	COG1271	oxidase subunit
C2D63_RS17110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2D63_RS17120	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D63_RS17125	COG0567	Dehydrogenase, E1 component
C2D63_RS17130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2D63_RS17135	COG1053	succinate dehydrogenase
C2D63_RS17140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2D63_RS17145	COG2009	succinate dehydrogenase
C2D63_RS17180	COG1984	allophanate hydrolase subunit 2
C2D63_RS17185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2D63_RS17200	COG0415	Belongs to the DNA photolyase family
C2D63_RS17230	COG2205	protein histidine kinase activity
C2D63_RS17235	COG0745	RESPONSE REGULATOR receiver
C2D63_RS17245	COG0033	Phosphoglucomutase
C2D63_RS17255	COG0596	Alpha beta hydrolase
C2D63_RS17270	COG0735	belongs to the Fur family
C2D63_RS17310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2D63_RS17315	COG1940	carbohydrate kinase activity
C2D63_RS17315	COG1846	Transcriptional regulator
C2D63_RS17320	COG0647	UMP catabolic process
C2D63_RS17325	COG0367	asparagine synthase
C2D63_RS17365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2D63_RS17375	COG1702	phosphate starvation-inducible protein PhoH
C2D63_RS17400	COG0765	amino acid transport
C2D63_RS17405	COG0765	amino acid transport
C2D63_RS17410	COG1126	abc transporter atp-binding protein
C2D63_RS17425	COG2888	peptidyl-tyrosine sulfation
C2D63_RS17440	COG1466	dna polymerase III delta subunit
C2D63_RS17455	COG0799	negative regulation of ribosome biogenesis
C2D63_RS17465	COG0768	penicillin binding
C2D63_RS17470	COG0772	Belongs to the SEDS family
C2D63_RS17475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2D63_RS17480	COG1686	Belongs to the peptidase S11 family
C2D63_RS17495	COG0583	DNA-binding transcription factor activity
C2D63_RS17505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2D63_RS17510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2D63_RS17530	COG3069	C4-dicarboxylate transmembrane transporter activity
C2D63_RS17535	COG3719	Belongs to the RNase T2 family
C2D63_RS17540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2D63_RS17560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2D63_RS17565	COG0583	DNA-binding transcription factor activity
C2D63_RS17570	COG3969	phosphoadenosine phosphosulfate
C2D63_RS17575	COG1475	DNA binding
C2D63_RS17580	COG0436	Aminotransferase
C2D63_RS17605	COG1129	ABC transporter
C2D63_RS17610	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS17615	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS17625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D63_RS17640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2D63_RS17650	COG0402	S-adenosylhomocysteine deaminase activity
C2D63_RS17660	COG0483	inositol monophosphate 1-phosphatase activity
C2D63_RS17665	COG2271	Major facilitator Superfamily
C2D63_RS17695	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS17700	COG1129	ABC transporter
C2D63_RS17705	COG0371	Dehydrogenase
C2D63_RS17710	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS17725	COG2879	small protein
C2D63_RS17730	COG1966	Carbon starvation protein
C2D63_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS17745	COG1535	isochorismatase
C2D63_RS17745	COG3433	isochorismatase activity
C2D63_RS17750	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2D63_RS17755	COG1169	isochorismate synthase
C2D63_RS17760	COG4592	Periplasmic binding protein
C2D63_RS17770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS17775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS17780	COG1120	ATPase activity
C2D63_RS17785	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2D63_RS17785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2D63_RS17790	COG3251	PFAM MbtH domain protein
C2D63_RS17795	COG2382	esterase
C2D63_RS17800	COG4771	TonB-dependent receptor
C2D63_RS17805	COG2977	Belongs to the P-Pant transferase superfamily
C2D63_RS17810	COG3958	Transketolase
C2D63_RS17815	COG3959	Transketolase, thiamine diphosphate binding domain
C2D63_RS17820	COG2390	Transcriptional regulator
C2D63_RS17825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2D63_RS17830	COG1879	ABC-type sugar transport system periplasmic component
C2D63_RS17840	COG1129	ABC transporter
C2D63_RS17845	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS17855	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS17865	COG0583	DNA-binding transcription factor activity
C2D63_RS17870	COG0668	transmembrane transport
C2D63_RS17880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2D63_RS17905	COG0747	negative chemotaxis
C2D63_RS17910	COG0601	transmembrane transport
C2D63_RS17915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS17920	COG0444	Belongs to the ABC transporter superfamily
C2D63_RS17925	COG4608	Belongs to the ABC transporter superfamily
C2D63_RS17935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2D63_RS17940	COG4221	oxidoreductase activity
C2D63_RS17950	COG4215	(ABC) transporter
C2D63_RS17955	COG0765	amino acid transport
C2D63_RS17960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2D63_RS17975	COG0697	spore germination
C2D63_RS17990	COG4608	Belongs to the ABC transporter superfamily
C2D63_RS17995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS18015	COG3698	Phosphodiester glycosidase
C2D63_RS18060	COG2315	Protein conserved in bacteria
C2D63_RS18065	COG0778	Nitroreductase
C2D63_RS18075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS18085	COG3716	PTS system mannose fructose sorbose family IID component
C2D63_RS18090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2D63_RS18095	COG2222	sugar isomerase
C2D63_RS18100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D63_RS18100	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2D63_RS18115	COG0477	Major facilitator Superfamily
C2D63_RS18120	COG0668	transmembrane transport
C2D63_RS18125	COG1609	Transcriptional regulator
C2D63_RS18135	COG0673	inositol 2-dehydrogenase activity
C2D63_RS18145	COG2211	Major facilitator Superfamily
C2D63_RS18150	COG1113	amino acid transport
C2D63_RS18165	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS18170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2D63_RS18180	COG0531	amino acid
C2D63_RS18225	COG0667	Aldo Keto reductase
C2D63_RS18230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS18235	COG1473	amidohydrolase
C2D63_RS18255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS18260	COG1120	ATPase activity
C2D63_RS18265	COG1566	PFAM secretion protein HlyD family protein
C2D63_RS18310	COG4211	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS18315	COG1129	ABC transporter
C2D63_RS18330	COG0673	inositol 2-dehydrogenase activity
C2D63_RS18360	COG3104	oligopeptide transport
C2D63_RS18365	COG1982	Orn Lys Arg decarboxylase major
C2D63_RS18370	COG0531	amino acid
C2D63_RS18375	COG3710	Transcriptional regulator
C2D63_RS18385	COG1560	Kdo2-lipid A biosynthetic process
C2D63_RS18400	COG3188	usher protein
C2D63_RS18405	COG3121	Chaperone
C2D63_RS18410	COG3539	Fimbrial protein
C2D63_RS18455	COG2501	S4 domain
C2D63_RS18460	COG1988	membrane-bound metal-dependent
C2D63_RS18480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2D63_RS18495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2D63_RS18500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2D63_RS18505	COG0549	Belongs to the carbamate kinase family
C2D63_RS18515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2D63_RS18520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2D63_RS18525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2D63_RS18530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2D63_RS18535	COG3257	ureidoglycine aminohydrolase activity
C2D63_RS18540	COG1929	Belongs to the glycerate kinase type-1 family
C2D63_RS18545	COG2233	PERMEase
C2D63_RS18555	COG1953	Uracil, thiamine, allantoin
C2D63_RS18565	COG2084	Dehydrogenase
C2D63_RS18570	COG3622	Belongs to the hyi family
C2D63_RS18575	COG3960	tartronate-semialdehyde synthase activity
C2D63_RS18605	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2D63_RS18610	COG4181	ATPase activity
C2D63_RS18615	COG2755	lipolytic protein G-D-S-L family
C2D63_RS18620	COG0300	oxidoreductase activity
C2D63_RS18625	COG3118	belongs to the thioredoxin family
C2D63_RS18630	COG0390	transport system, permease component
C2D63_RS18635	COG4619	ABC transporter
C2D63_RS18640	COG0330	HflC and HflK could
C2D63_RS18645	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2D63_RS18660	COG3735	TraB family
C2D63_RS18665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D63_RS18675	COG2223	nitrite transmembrane transporter activity
C2D63_RS18680	COG4651	solute:proton antiporter activity
C2D63_RS18680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2D63_RS18685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D63_RS18725	COG2832	Protein of unknown function (DUF454)
C2D63_RS18730	COG3923	Primosomal replication protein n
C2D63_RS18745	COG3264	Mechanosensitive ion channel
C2D63_RS18745	COG1196	nuclear chromosome segregation
C2D63_RS18750	COG1309	transcriptional regulator
C2D63_RS18755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS18760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D63_RS18775	COG0110	maltose O-acetyltransferase activity
C2D63_RS18820	COG1874	Beta-galactosidase
C2D63_RS18825	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2D63_RS18830	COG3833	ABC-type maltose transport systems, permease component
C2D63_RS18835	COG1175	transmembrane transport
C2D63_RS18840	COG2182	Extracellular solute-binding protein
C2D63_RS18850	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2D63_RS18865	COG2364	Membrane
C2D63_RS18895	COG3695	enzyme binding
C2D63_RS18900	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2D63_RS18905	COG1946	Acyl-CoA thioesterase
C2D63_RS18910	COG0004	ammonium transporteR
C2D63_RS18915	COG0347	Belongs to the P(II) protein family
C2D63_RS18920	COG1132	(ABC) transporter
C2D63_RS18925	COG1132	(ABC) transporter
C2D63_RS18930	COG1522	sequence-specific DNA binding
C2D63_RS18945	COG4533	DNA binding
C2D63_RS18955	COG0824	Thioesterase
C2D63_RS18960	COG1555	photosystem II stabilization
C2D63_RS18965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D63_RS18970	COG0776	regulation of translation
C2D63_RS18975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2D63_RS19000	COG0271	Belongs to the BolA IbaG family
C2D63_RS19005	COG3056	Lipoprotein
C2D63_RS19010	COG2223	nitrite transmembrane transporter activity
C2D63_RS19015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2D63_RS19020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2D63_RS19025	COG1845	cytochrome c oxidase, subunit III
C2D63_RS19030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2D63_RS19045	COG1414	Transcriptional regulator
C2D63_RS19050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2D63_RS19055	COG1053	succinate dehydrogenase
C2D63_RS19065	COG1053	succinate dehydrogenase
C2D63_RS19080	COG0673	inositol 2-dehydrogenase activity
C2D63_RS19085	COG2814	Major facilitator Superfamily
C2D63_RS19095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2D63_RS19100	COG0693	protein deglycase activity
C2D63_RS19120	COG0142	geranyltranstransferase activity
C2D63_RS19130	COG0667	Aldo Keto reductase
C2D63_RS19135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2D63_RS19155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2D63_RS19155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2D63_RS19165	COG4238	major outer membrane lipoprotein
C2D63_RS19185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2D63_RS19190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2D63_RS19195	COG1862	Preprotein translocase
C2D63_RS19215	COG0450	alkyl hydroperoxide reductase
C2D63_RS19220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS19235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D63_RS19245	COG1228	amidohydrolase
C2D63_RS19255	COG1335	isochorismatase
C2D63_RS19260	COG0583	DNA-binding transcription factor activity
C2D63_RS19265	COG0366	Alpha amylase catalytic
C2D63_RS19290	COG0420	3'-5' exonuclease activity
C2D63_RS19295	COG0419	ATPase involved in DNA repair
C2D63_RS19300	COG1940	carbohydrate kinase activity
C2D63_RS19315	COG4126	flavin adenine dinucleotide binding
C2D63_RS19325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2D63_RS19330	COG3416	Protein conserved in bacteria
C2D63_RS19340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2D63_RS19350	COG1785	Belongs to the alkaline phosphatase family
C2D63_RS19390	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2D63_RS19395	COG1335	isochorismatase
C2D63_RS19400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2D63_RS19405	COG0113	porphobilinogen synthase activity
C2D63_RS19415	COG2175	clavaminate synthase activity
C2D63_RS19420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2D63_RS19425	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2D63_RS19430	COG4521	taurine ABC transporter
C2D63_RS19435	COG2040	homocysteine
C2D63_RS19440	COG0833	amino acid
C2D63_RS19450	COG4303	Ethanolamine ammonia lyase large subunit
C2D63_RS19455	COG4302	ethanolamine ammonia-lyase activity
C2D63_RS19490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS19495	COG1126	abc transporter atp-binding protein
C2D63_RS19500	COG4597	amino acid ABC transporter
C2D63_RS19505	COG0765	amino acid transport
C2D63_RS19520	COG3188	usher protein
C2D63_RS19545	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2D63_RS19555	COG3639	organic phosphonate transmembrane transporter activity
C2D63_RS19575	COG0791	NLP P60 protein
C2D63_RS19625	COG2909	trisaccharide binding
C2D63_RS19630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2D63_RS19635	COG0022	dehydrogenase e1 component
C2D63_RS19640	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D63_RS19645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D63_RS19665	COG1070	Carbohydrate kinase
C2D63_RS19670	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS19675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2D63_RS19680	COG3775	system Galactitol-specific IIC component
C2D63_RS19685	COG0625	glutathione transferase activity
C2D63_RS19690	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2D63_RS19705	COG0579	oxidoreductase
C2D63_RS19710	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS19715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2D63_RS19720	COG1113	amino acid transport
C2D63_RS19725	COG1802	Transcriptional regulator
C2D63_RS19745	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2D63_RS19750	COG0454	-acetyltransferase
C2D63_RS19765	COG2991	Protein conserved in bacteria
C2D63_RS19780	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2D63_RS19785	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2D63_RS19800	COG3034	peptidoglycan biosynthetic process
C2D63_RS19805	COG0121	glutamine amidotransferase
C2D63_RS19815	COG1960	acyl-CoA dehydrogenase activity
C2D63_RS19820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2D63_RS19830	COG0583	DNA-binding transcription factor activity
C2D63_RS19840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2D63_RS19850	COG2226	methyltransferase
C2D63_RS19860	COG1388	LysM domain
C2D63_RS19860	COG0741	lytic transglycosylase activity
C2D63_RS19865	COG2226	methyltransferase
C2D63_RS19875	COG2814	Major facilitator Superfamily
C2D63_RS19880	COG0583	DNA-binding transcription factor activity
C2D63_RS19885	COG0656	L-ascorbic acid biosynthetic process
C2D63_RS19920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2D63_RS19930	COG2011	ABC-type metal ion transport system permease component
C2D63_RS19935	COG1464	Belongs to the NlpA lipoprotein family
C2D63_RS19945	COG1720	tRNA m6t6A37 methyltransferase activity
C2D63_RS19955	COG0791	NLP P60 protein
C2D63_RS19960	COG3015	lipoprotein NlpE involved in copper resistance
C2D63_RS19965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2D63_RS19980	COG4568	rho-dependent transcription termination
C2D63_RS19990	COG0346	lactoylglutathione lyase activity
C2D63_RS19995	COG1982	Orn Lys Arg decarboxylase major
C2D63_RS20005	COG0587	DNA-directed DNA polymerase activity
C2D63_RS20035	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2D63_RS20045	COG0750	zinc metalloprotease
C2D63_RS20050	COG0575	Belongs to the CDS family
C2D63_RS20060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2D63_RS20085	COG0024	Methionine aminopeptidase
C2D63_RS20090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2D63_RS20105	COG3835	regulator
C2D63_RS20110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2D63_RS20130	COG2860	membrane
C2D63_RS20155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS20160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2D63_RS20165	COG1120	ATPase activity
C2D63_RS20170	COG4774	siderophore transport
C2D63_RS20175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2D63_RS20270	COG1643	Atp-dependent helicase
C2D63_RS20275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2D63_RS20295	COG0617	tRNA 3'-terminal CCA addition
C2D63_RS20300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2D63_RS20320	COG0726	polysaccharide deacetylase
C2D63_RS20325	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS20330	COG0842	Transport permease protein
C2D63_RS20335	COG1131	(ABC) transporter
C2D63_RS20340	COG0288	reversible hydration of carbon dioxide
C2D63_RS20350	COG4993	Dehydrogenase
C2D63_RS20355	COG2132	Multicopper oxidase
C2D63_RS20400	COG3064	Membrane
C2D63_RS20415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2D63_RS20420	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2D63_RS20425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2D63_RS20430	COG2186	Transcriptional regulator
C2D63_RS20435	COG1113	amino acid transport
C2D63_RS20440	COG2211	Major facilitator Superfamily
C2D63_RS20445	COG3940	Belongs to the glycosyl hydrolase 43 family
C2D63_RS20450	COG3725	Membrane protein required for beta-lactamase induction
C2D63_RS20455	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2D63_RS20465	COG4969	Belongs to the N-Me-Phe pilin family
C2D63_RS20470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2D63_RS20475	COG1459	type II secretion system
C2D63_RS20500	COG0494	nUDIX hydrolase
C2D63_RS20520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2D63_RS20525	COG0849	cell division
C2D63_RS20550	COG0772	Belongs to the SEDS family
C2D63_RS20565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2D63_RS20570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2D63_RS20575	COG0768	penicillin binding
C2D63_RS20595	COG1609	Transcriptional regulator
C2D63_RS20605	COG0028	Belongs to the TPP enzyme family
C2D63_RS20650	COG0738	Major facilitator superfamily
C2D63_RS20660	COG0583	DNA-binding transcription factor activity
C2D63_RS20665	COG2271	Major facilitator Superfamily
C2D63_RS20670	COG2814	Major facilitator Superfamily
C2D63_RS20690	COG1178	ABC-type Fe3 transport system permease component
C2D63_RS20700	COG0586	Pfam SNARE associated Golgi protein
C2D63_RS20720	COG0235	Class ii aldolase
C2D63_RS20725	COG0417	DNA replication proofreading
C2D63_RS20735	COG0564	pseudouridine synthase activity
C2D63_RS20745	COG3493	citrate carrier protein
C2D63_RS20760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2D63_RS20765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2D63_RS20775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2D63_RS20820	COG0505	Belongs to the CarA family
C2D63_RS20830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2D63_RS20855	COG1047	Peptidyl-prolyl cis-trans
C2D63_RS20870	COG0196	riboflavin kinase activity
C2D63_RS20885	COG0583	DNA-binding transcription factor activity
C2D63_RS20910	COG4735	regulation of single-species biofilm formation
C2D63_RS20915	COG1584	GPR1 FUN34 yaaH family protein
C2D63_RS20920	COG0477	Major facilitator Superfamily
C2D63_RS20925	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2D63_RS20930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2D63_RS20935	COG1115	amino acid carrier protein
C2D63_RS20950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2D63_RS20960	COG0527	aspartate kinase activity
C2D63_RS20960	COG0460	homoserine dehydrogenase
C2D63_RS20970	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2D63_RS20980	COG0745	RESPONSE REGULATOR receiver
C2D63_RS20985	COG4452	Inner membrane protein CreD
C2D63_RS20990	COG2205	protein histidine kinase activity
C2D63_RS20995	COG0745	RESPONSE REGULATOR receiver
C2D63_RS21000	COG3045	CreA protein
C2D63_RS21005	COG3708	Transcriptional regulator
C2D63_RS21005	COG2207	Transcriptional regulator
C2D63_RS21025	COG0741	lytic transglycosylase activity
C2D63_RS21030	COG0488	(ABC) transporter
C2D63_RS21040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2D63_RS21045	COG0560	Phosphoserine phosphatase
C2D63_RS21050	COG3726	membrane protein affecting hemolysin expression
C2D63_RS21080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2D63_RS21085	COG0084	hydrolase, TatD family'
C2D63_RS21090	COG4667	esterase of the alpha-beta hydrolase superfamily
C2D63_RS21100	COG2823	Periplasmic or secreted lipoprotein
C2D63_RS21110	COG1011	Hydrolase
C2D63_RS21115	COG0456	acetyltransferase
C2D63_RS21120	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2D63_RS21150	COG3706	GGDEF domain
C2D63_RS21155	COG4114	ferric iron reductase
C2D63_RS21160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS21160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS21165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2D63_RS21170	COG2197	response regulator
C2D63_RS21175	COG2197	response regulator
C2D63_RS21190	COG2966	Psort location CytoplasmicMembrane, score
C2D63_RS21205	COG1484	DNA-dependent DNA replication
C2D63_RS21220	COG5464	transposase or invertase
C2D63_RS21230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2D63_RS21235	COG3716	PTS system mannose fructose sorbose family IID component
C2D63_RS21240	COG3715	PTS system
C2D63_RS21255	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2D63_RS21255	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2D63_RS21260	COG1214	PFAM Peptidase M22, glycoprotease
C2D63_RS21260	COG0456	acetyltransferase
C2D63_RS21270	COG1737	Transcriptional regulator
C2D63_RS21275	COG0800	Aldolase
C2D63_RS21280	COG3734	2-keto-3-deoxy-galactonokinase
C2D63_RS21295	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2D63_RS21315	COG1846	Transcriptional regulator
C2D63_RS21325	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2D63_RS21335	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS21340	COG3384	dioxygenase
C2D63_RS21350	COG3971	2-oxopent-4-enoate hydratase activity
C2D63_RS21370	COG2368	4-hydroxyphenylacetate
C2D63_RS21375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2D63_RS21390	COG1966	Carbon starvation protein
C2D63_RS21395	COG2879	small protein
C2D63_RS21400	COG0523	cobalamin synthesis protein
C2D63_RS21410	COG1012	belongs to the aldehyde dehydrogenase family
C2D63_RS21415	COG5464	transposase or invertase
C2D63_RS21420	COG1917	Cupin 2, conserved barrel domain protein
C2D63_RS21420	COG2207	Transcriptional regulator
C2D63_RS21430	COG2733	membrane
C2D63_RS21445	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2D63_RS21450	COG1924	4 iron, 4 sulfur cluster binding
C2D63_RS21465	COG1566	PFAM secretion protein HlyD family protein
C2D63_RS21475	COG5457	Domain of unknown function (DUF1127)
C2D63_RS21480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D63_RS21490	COG0583	DNA-binding transcription factor activity
C2D63_RS21495	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2D63_RS21505	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS21510	COG1129	ABC transporter
C2D63_RS21515	COG1879	ABC-type sugar transport system periplasmic component
C2D63_RS21525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS21530	COG1129	ABC transporter
C2D63_RS21530	COG0842	Transport permease protein
C2D63_RS21535	COG0842	Transport permease protein
C2D63_RS21565	COG2850	peptidyl-arginine hydroxylation
C2D63_RS21580	COG5002	protein histidine kinase activity
C2D63_RS21585	COG0745	RESPONSE REGULATOR receiver
C2D63_RS21590	COG1538	Outer membrane efflux protein
C2D63_RS21595	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS21600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS21605	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2D63_RS21615	COG3040	lipid binding
C2D63_RS21620	COG0789	Transcriptional regulator
C2D63_RS21625	COG3631	Ketosteroid isomerase-related protein
C2D63_RS21630	COG0300	oxidoreductase activity
C2D63_RS21645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2D63_RS21665	COG3272	Protein of unknown function (DUF1722)
C2D63_RS21670	COG4580	involved in the transport of maltose and maltodextrins
C2D63_RS21675	COG2115	Belongs to the xylose isomerase family
C2D63_RS21680	COG2211	Major facilitator Superfamily
C2D63_RS21685	COG3507	Belongs to the glycosyl hydrolase 43 family
C2D63_RS21705	COG1216	Glycosyl transferase, family 2
C2D63_RS21815	COG0071	Belongs to the small heat shock protein (HSP20) family
C2D63_RS21925	COG3423	Transcriptional regulator
C2D63_RS21940	COG3732	PTS system glucitol sorbitol-specific
C2D63_RS21945	COG0673	inositol 2-dehydrogenase activity
C2D63_RS21965	COG3121	Chaperone
C2D63_RS21975	COG0582	viral genome integration into host DNA
C2D63_RS22060	COG0582	viral genome integration into host DNA
C2D63_RS22070	COG0288	reversible hydration of carbon dioxide
C2D63_RS22075	COG0659	secondary active sulfate transmembrane transporter activity
C2D63_RS22080	COG1064	alcohol dehydrogenase
C2D63_RS22085	COG1175	transmembrane transport
C2D63_RS22090	COG0395	ABC-type sugar transport system, permease component
C2D63_RS22095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2D63_RS22100	COG3842	ATPase activity
C2D63_RS22115	COG1082	Xylose isomerase domain protein TIM barrel
C2D63_RS22125	COG3962	Belongs to the TPP enzyme family
C2D63_RS22130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D63_RS22135	COG0837	glucose binding
C2D63_RS22135	COG1737	Transcriptional regulator
C2D63_RS22140	COG3718	enzyme involved in inositol metabolism
C2D63_RS22155	COG0433	COG0433 Predicted ATPase
C2D63_RS22160	COG0795	lipopolysaccharide-transporting ATPase activity
C2D63_RS22165	COG0795	lipopolysaccharide-transporting ATPase activity
C2D63_RS22175	COG2927	DNA polymerase III (CHI subunit)
C2D63_RS22180	COG0525	valine-tRNA ligase activity
C2D63_RS22205	COG2731	YhcH YjgK YiaL family protein
C2D63_RS22245	COG1263	PTS System
C2D63_RS22245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2D63_RS22250	COG0366	Alpha amylase catalytic
C2D63_RS22255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2D63_RS22260	COG1486	melibiose metabolic process
C2D63_RS22280	COG0602	queuosine metabolic process
C2D63_RS22285	COG2026	Addiction module toxin, RelE StbE family
C2D63_RS22290	COG3077	Addiction module antitoxin, RelB DinJ family
C2D63_RS22295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2D63_RS22295	COG3711	transcriptional antiterminator
C2D63_RS22300	COG2706	6-phosphogluconolactonase activity
C2D63_RS22315	COG3964	amidohydrolase
C2D63_RS22350	COG0312	modulator of DNA gyrase
C2D63_RS22370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2D63_RS22380	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS22385	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS22390	COG1129	ABC transporter
C2D63_RS22395	COG1879	ABC-type sugar transport system periplasmic component
C2D63_RS22410	COG2105	PFAM AIG2 family protein
C2D63_RS22415	COG2911	Protein conserved in bacteria
C2D63_RS22420	COG0729	surface antigen
C2D63_RS22430	COG1253	flavin adenine dinucleotide binding
C2D63_RS22445	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2D63_RS22460	COG1733	regulation of RNA biosynthetic process
C2D63_RS22465	COG0702	epimerase
C2D63_RS22475	COG0697	spore germination
C2D63_RS22485	COG1113	amino acid transport
C2D63_RS22490	COG0545	Peptidyl-prolyl cis-trans isomerase
C2D63_RS22495	COG3061	Opacity-associated protein A
C2D63_RS22505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2D63_RS22510	COG2965	DNA replication, synthesis of RNA primer
C2D63_RS22570	COG1073	alpha beta
C2D63_RS22575	COG3650	response to hydrogen peroxide
C2D63_RS22585	COG1960	acyl-CoA dehydrogenase activity
C2D63_RS22590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2D63_RS22595	COG0557	exoribonuclease II activity
C2D63_RS22610	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2D63_RS22620	COG0330	HflC and HflK could
C2D63_RS22625	COG0330	HflC and HflK could
C2D63_RS22630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2D63_RS22650	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2D63_RS22655	COG0802	atpase or kinase
C2D63_RS22660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2D63_RS22660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2D63_RS22665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2D63_RS22685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2D63_RS22705	COG3264	Mechanosensitive ion channel
C2D63_RS22705	COG1511	domain protein
C2D63_RS22720	COG1053	succinate dehydrogenase
C2D63_RS22725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2D63_RS22745	COG2076	Multidrug Resistance protein
C2D63_RS22750	COG5510	response to toxic substance
C2D63_RS22765	COG1509	lysine 2,3-aminomutase activity
C2D63_RS22830	COG0531	amino acid
C2D63_RS22835	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2D63_RS22840	COG1027	Aspartate ammonia-lyase
C2D63_RS22845	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2D63_RS22860	COG1309	transcriptional regulator
C2D63_RS22895	COG0457	Tetratricopeptide repeat
C2D63_RS22900	COG0726	polysaccharide deacetylase
C2D63_RS22900	COG1649	PFAM Uncharacterised BCR, COG1649
C2D63_RS22905	COG1215	transferase activity, transferring glycosyl groups
C2D63_RS22920	COG0861	Integral membrane protein TerC family
C2D63_RS22950	COG1486	melibiose metabolic process
C2D63_RS22955	COG2169	Transcriptional regulator
C2D63_RS22965	COG2824	Alkylphosphonate utilization operon protein PhnA
C2D63_RS22970	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C2D63_RS22975	COG2188	Transcriptional regulator
C2D63_RS22980	COG3624	Phosphonate C-P lyase system protein PhnG
C2D63_RS22985	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2D63_RS22990	COG3626	phosphonate metabolism
C2D63_RS22995	COG3627	carbon phosphorus lyase activity
C2D63_RS23000	COG4107	phosphonate C-P lyase system protein PhnK
C2D63_RS23005	COG4778	phosphonate C-P lyase system protein PhnL
C2D63_RS23010	COG3454	Phosphonate metabolism
C2D63_RS23020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2D63_RS23030	COG4191	Histidine kinase
C2D63_RS23030	COG0784	Response regulator, receiver
C2D63_RS23035	COG1129	ABC transporter
C2D63_RS23040	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS23065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2D63_RS23070	COG1301	dicarboxylic acid transport
C2D63_RS23080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2D63_RS23085	COG3162	membrane
C2D63_RS23115	COG3539	Fimbrial protein
C2D63_RS23120	COG1346	cytolysis
C2D63_RS23125	COG1380	Effector of murein hydrolase LrgA
C2D63_RS23130	COG0583	DNA-binding transcription factor activity
C2D63_RS23135	COG0025	NhaP-type Na H and K H
C2D63_RS23140	COG2252	PERMEase
C2D63_RS23145	COG0625	glutathione transferase activity
C2D63_RS23150	COG0789	Transcriptional regulator
C2D63_RS23160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2D63_RS23190	COG1234	tRNA 3'-trailer cleavage
C2D63_RS23195	COG1609	Transcriptional regulator
C2D63_RS23200	COG0483	inositol monophosphate 1-phosphatase activity
C2D63_RS23210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2D63_RS23230	COG4771	TonB-dependent receptor
C2D63_RS23235	COG0741	lytic transglycosylase activity
C2D63_RS23250	COG2315	Protein conserved in bacteria
C2D63_RS23255	COG0432	Pfam Uncharacterised protein family UPF0047
C2D63_RS23270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2D63_RS23275	COG0305	Participates in initiation and elongation during chromosome replication
C2D63_RS23290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2D63_RS23300	COG0735	belongs to the Fur family
C2D63_RS23305	COG3237	CsbD-like
C2D63_RS23310	COG0534	Mate efflux family protein
C2D63_RS23320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2D63_RS23390	COG0251	oxidation-reduction process
C2D63_RS23400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2D63_RS23410	COG0527	aspartate kinase activity
C2D63_RS23460	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2D63_RS23470	COG0456	acetyltransferase
C2D63_RS23500	COG0151	Belongs to the GarS family
C2D63_RS23510	COG4191	Histidine kinase
C2D63_RS23515	COG3678	ATP-independent chaperone mediated protein folding
C2D63_RS23550	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2D63_RS23565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2D63_RS23570	COG2104	thiamine diphosphate biosynthetic process
C2D63_RS23585	COG3706	GGDEF domain
C2D63_RS23595	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2D63_RS23600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2D63_RS23635	COG0250	Participates in transcription elongation, termination and antitermination
C2D63_RS23710	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2D63_RS23720	COG1739	Uncharacterized protein family UPF0029
C2D63_RS23760	COG0805	protein transport
C2D63_RS23780	COG3165	ubiquinone biosynthetic process from chorismate
C2D63_RS23810	COG0583	DNA-binding transcription factor activity
C2D63_RS23815	COG0697	spore germination
C2D63_RS23820	COG0561	phosphatase activity
C2D63_RS23825	COG2267	carboxylic ester hydrolase activity
C2D63_RS23830	COG1280	lysine exporter protein (LysE YggA)
C2D63_RS23840	COG1280	lysine exporter protein (LysE YggA)
C2D63_RS23870	COG0210	DNA helicase
C2D63_RS23875	COG1011	Hydrolase
C2D63_RS23905	COG3072	Adenylate cyclase
C2D63_RS23920	COG2959	enzyme of heme biosynthesis
C2D63_RS23925	COG3071	HemY protein
C2D63_RS23970	COG2244	polysaccharide biosynthetic process
C2D63_RS23975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2D63_RS23980	COG0456	acetyltransferase
C2D63_RS23985	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2D63_RS23990	COG1088	dTDP-glucose 4,6-dehydratase activity
C2D63_RS23995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2D63_RS24000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2D63_RS24010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2D63_RS24015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2D63_RS24020	COG3118	belongs to the thioredoxin family
C2D63_RS24045	COG1811	Na channel or pump
C2D63_RS24055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D63_RS24060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2D63_RS24070	COG0583	DNA-binding transcription factor activity
C2D63_RS24075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2D63_RS24090	COG3978	acetolactate synthase activity
C2D63_RS24110	COG3085	chromosome segregation
C2D63_RS24185	COG0583	DNA-binding transcription factor activity
C2D63_RS24200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2D63_RS24215	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2D63_RS24220	COG2207	Transcriptional regulator
C2D63_RS24230	COG0371	Dehydrogenase
C2D63_RS24235	COG0697	spore germination
C2D63_RS24245	COG0583	DNA-binding transcription factor activity
C2D63_RS24255	COG0737	Belongs to the 5'-nucleotidase family
C2D63_RS24265	COG0527	aspartate kinase activity
C2D63_RS24265	COG0460	homoserine dehydrogenase
C2D63_RS24270	COG0626	cystathionine gamma-synthase activity
C2D63_RS24285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2D63_RS24290	COG1609	Transcriptional regulator
C2D63_RS24295	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2D63_RS24310	COG1575	Belongs to the MenA family. Type 1 subfamily
C2D63_RS24330	COG3678	ATP-independent chaperone mediated protein folding
C2D63_RS24335	COG0745	RESPONSE REGULATOR receiver
C2D63_RS24340	COG2205	protein histidine kinase activity
C2D63_RS24345	COG2258	MOSC domain
C2D63_RS24350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2D63_RS24390	COG1129	ABC transporter
C2D63_RS24395	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS24400	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS24405	COG1454	alcohol dehydrogenase
C2D63_RS24415	COG2211	Major facilitator Superfamily
C2D63_RS24475	COG0205	6-phosphofructokinase activity
C2D63_RS24495	COG0437	4 iron, 4 sulfur cluster binding
C2D63_RS24500	COG2864	formate dehydrogenase
C2D63_RS24515	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2D63_RS24525	COG0456	acetyltransferase
C2D63_RS24540	COG1011	Hydrolase
C2D63_RS24555	COG3852	Histidine kinase
C2D63_RS24570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2D63_RS24590	COG0204	Acyl-transferase
C2D63_RS24600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2D63_RS24605	COG3084	Protein conserved in bacteria
C2D63_RS24615	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2D63_RS24640	COG2186	Transcriptional regulator
C2D63_RS24645	COG0477	Major facilitator Superfamily
C2D63_RS24650	COG1609	Transcriptional regulator
C2D63_RS24655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2D63_RS24665	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2D63_RS24670	COG1129	ABC transporter
C2D63_RS24700	COG1522	sequence-specific DNA binding
C2D63_RS24705	COG0716	FMN binding
C2D63_RS24720	COG3312	ion transport
C2D63_RS24775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2D63_RS24780	COG0573	inorganic phosphate transmembrane transporter activity
C2D63_RS24785	COG0581	inorganic phosphate transmembrane transporter activity
C2D63_RS24790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2D63_RS24795	COG0704	Plays a role in the regulation of phosphate uptake
C2D63_RS24805	COG2382	esterase
C2D63_RS24810	COG0363	glucosamine-6-phosphate deaminase activity
C2D63_RS24815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2D63_RS24820	COG2252	PERMEase
C2D63_RS24825	COG0431	NADPH-dependent FMN reductase
C2D63_RS24830	COG2091	lysine biosynthetic process via aminoadipic acid
C2D63_RS24860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2D63_RS24975	COG1956	GAF domain-containing protein
C2D63_RS25045	COG1522	sequence-specific DNA binding
C2D63_RS25060	COG1028	Short-chain dehydrogenase reductase Sdr
C2D63_RS25060	COG3321	synthase
C2D63_RS25060	COG0604	alcohol dehydrogenase
C2D63_RS25150	COG1358	cellular component organization or biogenesis
C2D63_RS25170	COG4245	von Willebrand factor, type A
C2D63_RS25180	COG4245	von Willebrand factor, type A
C2D63_RS25185	COG4245	von Willebrand factor, type A
C2D63_RS25205	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
C2D63_RS25240	COG2144	transferase activity, transferring acyl groups
C2D63_RS25265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2D63_RS25350	COG4372	Transposase
C2D63_RS25355	COG3436	PFAM IS66 Orf2 family protein
C2D63_RS25515	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2D63_RS25545	COG0739	heme binding
C2D63_RS25555	COG2132	Multicopper oxidase
C2D63_RS25560	COG3667	copper resistance
C2D63_RS25565	COG2372	response to copper ion
C2D63_RS25570	COG1276	copper resistance
C2D63_RS25575	COG0745	RESPONSE REGULATOR receiver
C2D63_RS25580	COG2205	protein histidine kinase activity
C2D63_RS25585	COG0789	Transcriptional regulator
C2D63_RS25600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2D63_RS25625	COG5499	transcription regulator containing HTH domain
C2D63_RS25630	COG4680	protein conserved in bacteria
C2D63_RS25715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2D63_RS25755	COG0523	cobalamin synthesis protein
C2D63_RS25780	COG0523	cobalamin synthesis protein
C2D63_RS25785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2D63_RS25790	COG0735	belongs to the Fur family
C2D63_RS25830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2D63_RS25855	COG0656	L-ascorbic acid biosynthetic process
C2D63_RS25860	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2D63_RS25880	COG5654	RES domain protein
C2D63_RS25885	COG5642	Protein of unknown function (DUF2384)
C2D63_RS25900	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2D63_RS25905	COG4772	TonB-dependent receptor
C2D63_RS25915	COG1595	DNA-templated transcription, initiation
C2D63_RS25930	COG3969	phosphoadenosine phosphosulfate
C2D63_RS25935	COG1475	DNA binding
C2D63_RS25955	COG2382	esterase
C2D63_RS25990	COG0500	methyltransferase
C2D63_RS26025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C2D63_RS26035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2D63_RS26050	COG0500	methyltransferase