locus-tag class description H1Y02_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H1Y02_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H1Y02_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H1Y02_RS00025 ENOG410667J hydrolase H1Y02_RS00040 ENOG4105D99 atp gtp-binding protein H1Y02_RS00045 ENOG4105R2A (LipO)protein H1Y02_RS00060 ENOG4105D0C transport protein H1Y02_RS00065 ENOG4105FDP GntR family transcriptional regulator H1Y02_RS00070 ENOG4105CI1 PTS System H1Y02_RS00075 ENOG4105F8D glycoside hydrolase family 4 H1Y02_RS00080 ENOG4105VG5 Membrane H1Y02_RS00085 ENOG4105JP4 Inner membrane protein yidG H1Y02_RS00105 ENOG4105W8I Transcriptional regulator H1Y02_RS00110 ENOG4105E5M Multidrug resistance protein D H1Y02_RS00140 ENOG4105C7K acetolactate synthase H1Y02_RS00145 ENOG4105M71 acetolactate synthase 1 regulatory subunit H1Y02_RS00150 ENOG4108KX4 response regulator H1Y02_RS00155 ENOG4105BZU Histidine kinase H1Y02_RS00160 ENOG4105CXY transporter H1Y02_RS00165 ENOG4105CXY transporter H1Y02_RS00170 ENOG4108SAJ Protein of unknown function (DUF1198) H1Y02_RS00180 ENOG4108KAZ Involved in phosphonate degradation (By similarity) H1Y02_RS00185 ENOG4107STF Involved in phosphonate degradation (By similarity) H1Y02_RS00190 ENOG4106S9K Transcriptional regulator H1Y02_RS00200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS00205 ENOG4108MP3 ABC transporter, permease H1Y02_RS00220 ENOG4105F2I Transposase H1Y02_RS00225 ENOG4105CK1 PTS System H1Y02_RS00240 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS00245 ENOG4105D2S major facilitator superfamily H1Y02_RS00255 ENOG4107F9Y LysR family transcriptional regulator H1Y02_RS00265 ENOG4105JSC dimethylmenaquinone methyltransferase H1Y02_RS00275 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H1Y02_RS00280 ENOG4105T8A Uncharacterized protein YicS H1Y02_RS00285 ENOG4108UZ3 Transporter H1Y02_RS00290 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) H1Y02_RS00295 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H1Y02_RS00300 ENOG4105C2C drug resistance transporter, Bcr CflA H1Y02_RS00305 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H1Y02_RS00310 ENOG4105BZS acriflavin resistance protein H1Y02_RS00315 ENOG4105C1P efflux transporter, rnd family, mfp subunit H1Y02_RS00335 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H1Y02_RS00345 ENOG4105CR8 Transcriptional regulator H1Y02_RS00370 ENOG4105D01 (LipO)protein H1Y02_RS00385 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein H1Y02_RS00395 ENOG4105DQ4 alcohol dehydrogenase H1Y02_RS00405 ENOG4105CIS alcohol dehydrogenase H1Y02_RS00410 ENOG4105NI3 Protein of unknown function (DUF3237) H1Y02_RS00420 ENOG4105CT4 transporter H1Y02_RS00425 ENOG4105CJQ hydrolase, family 31 H1Y02_RS00435 ENOG4105F8D glycoside hydrolase family 4 H1Y02_RS00440 ENOG4105CI1 PTS System H1Y02_RS00445 ENOG4105JV1 AsmA family H1Y02_RS00450 ENOG4105C2W permease H1Y02_RS00455 ENOG4105D6U Sodium Glutamate Symporter H1Y02_RS00460 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H1Y02_RS00465 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H1Y02_RS00470 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) H1Y02_RS00475 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H1Y02_RS00490 ENOG4105CP7 Triose-phosphate isomerase H1Y02_RS00495 ENOG4105EBK exported protein H1Y02_RS00500 ENOG4108VTS Membrane H1Y02_RS00505 ENOG4105DP0 ferredoxin-NADP reductase H1Y02_RS00510 ENOG4105CBT Fructose-1,6-bisphosphatase H1Y02_RS00515 ENOG4105CB5 ATP-dependent DNA helicase recG H1Y02_RS00520 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase H1Y02_RS00525 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H1Y02_RS00535 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H1Y02_RS00545 ENOG4105EN6 Membrane H1Y02_RS00555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H1Y02_RS00560 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) H1Y02_RS00565 ENOG4105DSJ YicC domain protein H1Y02_RS00570 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H1Y02_RS00580 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) H1Y02_RS00585 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H1Y02_RS00590 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H1Y02_RS00595 ENOG4105W5Q DNA repair protein (RadC H1Y02_RS00600 ENOG4105KDC 50s ribosomal protein l28 H1Y02_RS00605 ENOG4105W0E 50S ribosomal protein L33 H1Y02_RS00610 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H1Y02_RS00615 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H1Y02_RS00620 ENOG4106WTF Glycosyl transferase, family 2 H1Y02_RS00625 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H1Y02_RS00630 ENOG4105K64 Glycosyl transferase, family 2 H1Y02_RS00635 ENOG4105CPK Glycosyl transferase (Group 1 H1Y02_RS00645 ENOG4105DKP glycosyl transferase, family 9 H1Y02_RS00670 ENOG4105D16 lipopolysaccharide heptosyltransferase i H1Y02_RS00675 ENOG4105XA0 heptosyltransferase ii H1Y02_RS00680 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) H1Y02_RS00685 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H1Y02_RS00695 ENOG4106WTF Glycosyl transferase, family 2 H1Y02_RS00700 ENOG4105PXI polysaccharide deacetylase H1Y02_RS00705 ENOG41063SB peptidase H1Y02_RS00715 ENOG4107YZP Rhodanese domain protein H1Y02_RS00720 ENOG4105VW4 glutaredoxin 3 H1Y02_RS00725 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) H1Y02_RS00735 ENOG4105D7W serine acetyltransferase H1Y02_RS00740 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H1Y02_RS00750 ENOG41073TP transcriptional regulator H1Y02_RS00755 ENOG4105DAA L-lactate H1Y02_RS00760 ENOG4108YYI Protein of unknown function (DUF2810) H1Y02_RS00775 ENOG4108RC0 Electron transport protein H1Y02_RS00780 ENOG4105JKW Valine--pyruvate aminotransferase H1Y02_RS00785 ENOG4107T9C Alpha amylase catalytic region H1Y02_RS00790 ENOG4108UR8 BAX protein H1Y02_RS00795 ENOG4105T16 Transcriptional regulator (AraC family) H1Y02_RS00800 ENOG4108HWW ABC transporter H1Y02_RS00805 ENOG4105C2J ABC transporter H1Y02_RS00810 ENOG4105DFW ABC transporter H1Y02_RS00815 ENOG4105C93 Xylose Isomerase H1Y02_RS00820 ENOG4105CMG Carbohydrate kinase H1Y02_RS00825 ENOG410688U Inner membrane protein yiaB H1Y02_RS00830 ENOG4105MEV Acyl-transferase H1Y02_RS00835 ENOG4105RGS lipoprotein ysaB H1Y02_RS00845 ENOG4105C38 Glycyl-tRNA synthetase beta subunit H1Y02_RS00860 ENOG4105F2I Transposase H1Y02_RS00865 ENOG41060TC Hok gef cell toxic protein H1Y02_RS00880 ENOG4105MVF Transcriptional regulator H1Y02_RS00885 ENOG4105D2S major facilitator superfamily H1Y02_RS00890 ENOG4106JH6 (LipO)protein H1Y02_RS00895 ENOG4105C5I Dehydrogenase H1Y02_RS00905 ENOG4105D7K pfkb domain protein H1Y02_RS00915 ENOG4108M60 Transcriptional regulator H1Y02_RS00920 ENOG4108ZG0 Ompa motb domain protein H1Y02_RS00925 ENOG4107QY8 reductase H1Y02_RS00930 ENOG4105HNP -acetyltransferase H1Y02_RS00935 ENOG4108R3E Dna-3-methyladenine glycosylase i H1Y02_RS00940 ENOG4105EAX Putative lipase H1Y02_RS00945 ENOG4105FCD Major Facilitator H1Y02_RS00950 ENOG4105DIJ Phosphoethanolamine transferase H1Y02_RS00975 ENOG4105DEF Extracellular solute-binding protein, family 5 H1Y02_RS00980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Y02_RS00985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS00990 ENOG4105C3U ABC transporter H1Y02_RS00995 ENOG4108JQ7 (ABC) transporter H1Y02_RS01015 ENOG4107U53 septum site-determining protein minD H1Y02_RS01020 ENOG4107QZ7 Cellulose synthase catalytic subunit H1Y02_RS01025 ENOG4107EEX Cellulose synthase regulator protein H1Y02_RS01030 ENOG4105EJG cellulose synthase H1Y02_RS01045 ENOG4105D1V cellulose synthase operon protein YhjU H1Y02_RS01050 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT H1Y02_RS01055 ENOG4105U74 cellulose biosynthesis protein BcsE H1Y02_RS01060 ENOG410661M cytoplasmic protein H1Y02_RS01065 ENOG4105UTS cellulose synthase operon protein YhjQ H1Y02_RS01070 ENOG4107QZ7 Cellulose synthase catalytic subunit H1Y02_RS01075 ENOG4107EEX Cellulose synthase regulator protein H1Y02_RS01080 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) H1Y02_RS01085 ENOG4105EJG cellulose synthase H1Y02_RS01090 ENOG4105BZU Histidine kinase H1Y02_RS01095 ENOG4105CK2 sodium dicarboxylate symporter H1Y02_RS01100 ENOG4105CS0 peptidase H1Y02_RS01110 ENOG41066T0 asmA family H1Y02_RS01115 ENOG4105CSH Transporter H1Y02_RS01120 ENOG4107H3J ribonuclease H1Y02_RS01125 ENOG4105CBN LysR family transcriptional regulator H1Y02_RS01130 ENOG4105CHR reductase H1Y02_RS01145 ENOG4105C0A alcohol dehydrogenase H1Y02_RS01155 ENOG4105DC8 reductase H1Y02_RS01160 ENOG4105D6S protein involved in catabolism of external DNA H1Y02_RS01165 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H1Y02_RS01170 ENOG4105DGW oligopeptidase A H1Y02_RS01180 ENOG4105DUX Transporter H1Y02_RS01295 ENOG4105CF2 Mu-like prophage FluMu protein GP28 H1Y02_RS01320 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) H1Y02_RS01425 ENOG4108V6B universal stress protein B H1Y02_RS01430 ENOG4105CJ3 phosphate transporter H1Y02_RS01435 ENOG4105CBX hi0933 family H1Y02_RS01440 ENOG4105CJW magnesium transporter H1Y02_RS01450 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS01460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS01465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Y02_RS01470 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein H1Y02_RS01480 ENOG4105PY6 Phenolic acid decarboxylase H1Y02_RS01490 ENOG4105CKK Glycosyl transferase, family 2 H1Y02_RS01495 ENOG4105C3I Nad-dependent epimerase dehydratase H1Y02_RS01515 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) H1Y02_RS01520 ENOG4105DSF transport protein H1Y02_RS01525 ENOG4105F9N Major Facilitator Superfamily H1Y02_RS01530 ENOG4108W1V Lipoprotein H1Y02_RS01535 ENOG4105EX9 Membrane H1Y02_RS01540 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) H1Y02_RS01550 ENOG4107FS9 Membrane H1Y02_RS01560 ENOG4105MG3 Membrane H1Y02_RS01565 ENOG4106H78 methyltransferase H1Y02_RS01570 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H1Y02_RS01575 ENOG4105CAK Cell division ATP-binding protein ftsE H1Y02_RS01580 ENOG4105CRP Part of the ABC transporter FtsEX involved in H1Y02_RS01595 ENOG4108JPW Aminotransferase H1Y02_RS01600 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS01610 ENOG4105CP9 extracellular ligand-binding receptor H1Y02_RS01615 ENOG4105EG3 transmembrane signal peptide protein H1Y02_RS01620 ENOG4108V0P LemA family H1Y02_RS01625 ENOG4105U59 -acetyltransferase H1Y02_RS01630 ENOG4105CP9 extracellular ligand-binding receptor H1Y02_RS01635 ENOG4105C32 Amino acid ABC transporter (Permease) H1Y02_RS01640 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H1Y02_RS01645 ENOG4105C0Z ABC transporter H1Y02_RS01650 ENOG4108IV0 ABC, transporter H1Y02_RS01655 ENOG4105BZ7 extracellular solute-binding protein family 1 H1Y02_RS01660 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component H1Y02_RS01675 ENOG4107T6V glycerophosphoryl diester phosphodiesterase H1Y02_RS01680 ENOG4105WC8 Conserved Protein H1Y02_RS01685 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H1Y02_RS01690 ENOG4105WCN acetyltransferase H1Y02_RS01700 ENOG4105D9R oxidoreductase H1Y02_RS01705 ENOG4105C2I pirin domain protein H1Y02_RS01710 ENOG4105DIQ Transcriptional regulator H1Y02_RS01715 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H1Y02_RS01720 ENOG4105C6Z Gluconate H1Y02_RS01730 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H1Y02_RS01735 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H1Y02_RS01740 ENOG4108IUM Glycogen debranching enzyme H1Y02_RS01745 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) H1Y02_RS01755 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H1Y02_RS01760 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H1Y02_RS01770 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) H1Y02_RS01775 ENOG4105E98 transcriptional regulator DeoR family H1Y02_RS01785 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H1Y02_RS01790 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) H1Y02_RS01795 ENOG4105C6Z Gluconate H1Y02_RS01800 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) H1Y02_RS01805 ENOG4105MJ2 Competence protein H1Y02_RS01810 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) H1Y02_RS01830 ENOG4105XFK Ferrous iron transport protein A H1Y02_RS01835 ENOG4105BZM domain protein H1Y02_RS01840 ENOG4108RRZ Transcription elongation factor GreB H1Y02_RS01850 ENOG4105E0F Histidine kinase H1Y02_RS01855 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase H1Y02_RS01865 ENOG4105VEJ Heat shock protein H1Y02_RS01870 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 H1Y02_RS01875 ENOG4105DQY intracellular growth attenuator H1Y02_RS01880 ENOG4107RK2 ADP-ribose diphosphatase NudE H1Y02_RS01885 ENOG4108JQC penicillin-binding protein 1A H1Y02_RS01890 ENOG4108U1Q Pilus assembly protein H1Y02_RS01910 ENOG4105E4G Type IV pilus H1Y02_RS01915 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H1Y02_RS01925 ENOG4105EGB membrane protein DamX H1Y02_RS01930 ENOG4105DFE Dna adenine methylase H1Y02_RS01935 ENOG4105DJV ribulose-phosphate 3-epimerase H1Y02_RS01945 ENOG4105C31 Tryptophanyl-tRNA synthetase H1Y02_RS01950 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H1Y02_RS01955 ENOG4105WZK nitrite reductase NADPH small subunit H1Y02_RS01960 ENOG4107QZF nitrite reductase NADPH large subunit H1Y02_RS01965 ENOG4105DZC cytosine deaminase H1Y02_RS01970 ENOG4106DTQ Protein TsgA homolog H1Y02_RS01975 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H1Y02_RS01980 ENOG4106195 uncharacterized protein yhfG H1Y02_RS01985 ENOG4105MZU cell filamentation protein H1Y02_RS01995 ENOG4105C8Y Acetylornithine aminotransferase H1Y02_RS02000 ENOG410613R integral membrane protein, YccS YhfK family H1Y02_RS02005 ENOG4107RYR Transcriptional regulator, Crp Fnr family H1Y02_RS02010 ENOG4108UKZ OsmC family H1Y02_RS02015 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) H1Y02_RS02025 ENOG4105DNZ Alpha Beta Hydrolase H1Y02_RS02030 ENOG4105C5H ABC transporter H1Y02_RS02035 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein H1Y02_RS02045 ENOG4105VKU nucleicacid-binding protein H1Y02_RS02050 ENOG4108YZY peptidylprolyl cis-trans isomerase H1Y02_RS02055 ENOG4105VRX Protein slyX homolog H1Y02_RS02060 ENOG4108V1T peptidylprolyl cis-trans isomerase H1Y02_RS02065 ENOG4105WWK YheO domain protein H1Y02_RS02070 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) H1Y02_RS02085 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H1Y02_RS02090 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H1Y02_RS02095 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H1Y02_RS02100 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H1Y02_RS02105 ENOG4105W53 bacterioferritin-associated ferredoxin H1Y02_RS02110 ENOG4108UQY Iron-storage protein H1Y02_RS02125 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H1Y02_RS02130 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H1Y02_RS02140 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H1Y02_RS02145 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) H1Y02_RS02150 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) H1Y02_RS02155 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H1Y02_RS02160 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) H1Y02_RS02165 ENOG41083MP 50s ribosomal protein l29 H1Y02_RS02170 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H1Y02_RS02175 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) H1Y02_RS02180 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H1Y02_RS02195 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H1Y02_RS02200 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H1Y02_RS02210 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H1Y02_RS02215 ENOG4105VPB 50S ribosomal protein L30 H1Y02_RS02220 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) H1Y02_RS02225 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H1Y02_RS02230 ENOG41067V7 50S ribosomal protein L36 H1Y02_RS02235 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H1Y02_RS02240 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) H1Y02_RS02245 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H1Y02_RS02250 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H1Y02_RS02255 ENOG4108ZT0 50S ribosomal protein l17 H1Y02_RS02260 ENOG4105VTS DnaJ-like, subfamily C H1Y02_RS02265 ENOG4105W1Y Transcriptional regulator H1Y02_RS02270 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system H1Y02_RS02275 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H1Y02_RS02280 ENOG4105C1A potassium transporter peripheral membrane H1Y02_RS02285 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H1Y02_RS02290 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H1Y02_RS02295 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H1Y02_RS02300 ENOG4105C79 DNA protecting protein DprA H1Y02_RS02310 ENOG4108WI1 Dna topoisomerase H1Y02_RS02315 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H1Y02_RS02320 ENOG4105E2X shikimate dehydrogenase H1Y02_RS02325 ENOG4105SG3 Protein of unknown function (DUF1488) H1Y02_RS02330 ENOG4108Z0R Transferase H1Y02_RS02360 ENOG4105XCM membrane LIPOPROTEIN H1Y02_RS02365 ENOG4105BZS acriflavin resistance protein H1Y02_RS02370 ENOG4105C1P efflux transporter, rnd family, mfp subunit H1Y02_RS02375 ENOG4108XG4 DNA-binding transcriptional regulator H1Y02_RS02395 ENOG4105XB7 anti-repressor protein H1Y02_RS02450 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS02460 ENOG4105PTU response to oxidative stress H1Y02_RS02480 ENOG4105F4R Transcriptional regulator mode H1Y02_RS02490 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H1Y02_RS02495 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) H1Y02_RS02500 ENOG4108IA2 Sodium pantothenate symporter H1Y02_RS02505 ENOG4105RG0 Membrane H1Y02_RS02510 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H1Y02_RS02515 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H1Y02_RS02525 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) H1Y02_RS02540 ENOG41062P1 Diguanylate cyclase phosphodiesterase H1Y02_RS02550 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) H1Y02_RS02555 ENOG4105VQ7 Rod shape-determining protein MreD H1Y02_RS02560 ENOG4108Z03 MAF-like protein H1Y02_RS02565 ENOG4105C03 ribonuclease H1Y02_RS02570 ENOG4105QD6 exported protein H1Y02_RS02575 ENOG4105D1U peptidase U62 modulator of DNA gyrase H1Y02_RS02580 ENOG4105CR8 Transcriptional regulator H1Y02_RS02595 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) H1Y02_RS02600 ENOG4105UNR (Barnase) inhibitor H1Y02_RS02605 ENOG4105RID UPF0379 protein yhcN H1Y02_RS02610 ENOG4105RID UPF0379 protein yhcN H1Y02_RS02615 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) H1Y02_RS02620 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H1Y02_RS02625 ENOG4105C0H protease H1Y02_RS02630 ENOG4105C0H protease H1Y02_RS02635 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III H1Y02_RS02640 ENOG4105D6Z AFG1 family ATPase H1Y02_RS02645 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H1Y02_RS02660 ENOG4107MKT Stringent starvation protein a H1Y02_RS02665 ENOG4105KB2 stringent starvation protein b H1Y02_RS02675 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H1Y02_RS02680 ENOG4105JHE Major Facilitator Superfamily H1Y02_RS02695 ENOG4108R66 Conserved Protein H1Y02_RS02700 ENOG4105BZ8 glutamate synthase H1Y02_RS02705 ENOG4105CBC glutamate synthase H1Y02_RS02710 ENOG4105N5T Radical SAM Protein H1Y02_RS02715 ENOG4108I5G Major Facilitator superfamily H1Y02_RS02720 ENOG4105CPQ Dehydrogenase H1Y02_RS02725 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) H1Y02_RS02730 ENOG4105BZU Histidine kinase H1Y02_RS02735 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain H1Y02_RS02745 ENOG41080Z8 PHOSPHOCARRIER protein H1Y02_RS02750 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H1Y02_RS02755 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN H1Y02_RS02760 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA H1Y02_RS02765 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Y02_RS02770 ENOG4108IUZ ABC transporter H1Y02_RS02775 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA H1Y02_RS02780 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) H1Y02_RS02790 ENOG4105C2X Arabinose 5-phosphate isomerase H1Y02_RS02795 ENOG4105FEU K -dependent Na -Ca exchanger H1Y02_RS02800 ENOG4105DHJ ABC, transporter H1Y02_RS02805 ENOG4105CY3 ABC transporter, permease H1Y02_RS02810 ENOG4107PE3 Mammalian cell entry related domain protein H1Y02_RS02815 ENOG4105E3I toluene tolerance H1Y02_RS02820 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane H1Y02_RS02825 ENOG4105VFK BolA family H1Y02_RS02835 ENOG4105HVQ Regulatory factor of maltose metabolism H1Y02_RS02840 ENOG4105EAH synthase H1Y02_RS02845 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H1Y02_RS02850 ENOG4105K46 50S ribosomal protein l27 H1Y02_RS02855 ENOG4105QYV Membrane H1Y02_RS02860 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H1Y02_RS02865 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase H1Y02_RS02870 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H1Y02_RS02875 ENOG4105HBR Rna-binding protein H1Y02_RS02880 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) H1Y02_RS02885 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H1Y02_RS02890 ENOG4105EEI dihydropteroate synthase H1Y02_RS02895 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H1Y02_RS02900 ENOG4105NTZ Preprotein translocase subunit SecG H1Y02_RS02915 ENOG4108UII YfaZ family H1Y02_RS02920 ENOG4108PNB DNA-binding transcriptional regulator H1Y02_RS02925 ENOG4105CDH Citrulline--aspartate ligase H1Y02_RS02935 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) H1Y02_RS02940 ENOG4105CHV Transcription elongation factor NusA H1Y02_RS02945 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) H1Y02_RS02950 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H1Y02_RS02955 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H1Y02_RS02960 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H1Y02_RS02965 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H1Y02_RS02980 ENOG4105C1J atp-dependent rna helicase H1Y02_RS02985 ENOG4105CIC tryptophan-specific transport protein H1Y02_RS02990 ENOG4105DEN Luciferase family H1Y02_RS03010 ENOG4108YYD acetyltransferase H1Y02_RS03015 ENOG41082IR Excinuclease ABC C subunit domain protein H1Y02_RS03020 ENOG4108ZPB UPF0306 protein H1Y02_RS03025 ENOG4107R7Y intracellular protease Pfpi family H1Y02_RS03030 ENOG4105K4T epimerase H1Y02_RS03035 ENOG4107S21 permease H1Y02_RS03040 ENOG4105W4M Transport-associated protein H1Y02_RS03045 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H1Y02_RS03055 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) H1Y02_RS03060 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H1Y02_RS03065 ENOG4105CTX dehydratase H1Y02_RS03070 ENOG4105CNV Aldolase H1Y02_RS03075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H1Y02_RS03100 ENOG4106D80 Uncharacterized protein YhaL H1Y02_RS03105 ENOG4108CNN domain protein H1Y02_RS03110 ENOG4105CWB LysR family transcriptional Regulator H1Y02_RS03115 ENOG4105KAF membrAne H1Y02_RS03120 ENOG4105CHF Glutathione S-transferase H1Y02_RS03125 ENOG4108VBZ doxx family H1Y02_RS03130 ENOG4105YJD H1Y02_RS03135 ENOG41090KG Inner membrane protein YqjE H1Y02_RS03140 ENOG4105NE1 Conserved Protein H1Y02_RS03145 ENOG4105WAY exported protein H1Y02_RS03150 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) H1Y02_RS03155 ENOG4106W5V Membrane H1Y02_RS03160 ENOG4107YCY Transcriptional regulator H1Y02_RS03165 ENOG4105DPW Major facilitator superfamily MFS_1 H1Y02_RS03175 ENOG4105CTX dehydratase H1Y02_RS03180 ENOG4105P66 Membrane H1Y02_RS03190 ENOG4105DU1 integral membrane protein, terc H1Y02_RS03195 ENOG4105EE0 oxidoreductase H1Y02_RS03200 ENOG4108VKG metal-dependent hydrolase H1Y02_RS03215 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) H1Y02_RS03220 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H1Y02_RS03225 ENOG4107RYS Autoinducer-2 (AI-2) kinase H1Y02_RS03230 ENOG4105DKT Transcriptional regulator H1Y02_RS03235 ENOG4105C2J ABC transporter H1Y02_RS03240 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane H1Y02_RS03245 ENOG4105F5R ABC transporter H1Y02_RS03250 ENOG4105D4B ABC, transporter H1Y02_RS03255 ENOG41061GT Aldolase H1Y02_RS03260 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound H1Y02_RS03265 ENOG4105C8Y Acetylornithine aminotransferase H1Y02_RS03270 ENOG4105NTW Transcriptional regulator H1Y02_RS03275 ENOG4105Q26 Siderophore-interacting protein H1Y02_RS03290 ENOG4108UTZ Dihydroxyacetone kinase H1Y02_RS03295 ENOG4105CMT Dihydroxyacetone kinase H1Y02_RS03315 ENOG4105XXV Acid-resistance protein H1Y02_RS03320 ENOG4105F2I Transposase H1Y02_RS03325 ENOG4108YK4 Acid-resistance membrane protein H1Y02_RS03330 ENOG4108V08 YfdX protein H1Y02_RS03335 ENOG4105BZU Histidine kinase H1Y02_RS03340 ENOG4108WQH regulatoR H1Y02_RS03355 ENOG4105F2I Transposase H1Y02_RS03455 ENOG4105CAR Terminase, large subunit H1Y02_RS03470 ENOG4108VCA G U mismatch-specific DNA glycosylase H1Y02_RS03475 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Y02_RS03480 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H1Y02_RS03490 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H1Y02_RS03500 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) H1Y02_RS03505 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) H1Y02_RS03525 ENOG4108YZ9 Urea amidohydrolase subunit gamma H1Y02_RS03530 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) H1Y02_RS03545 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) H1Y02_RS03550 ENOG4107ZVW dihydroneopterin aldolase H1Y02_RS03560 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate H1Y02_RS03565 ENOG4106MWK domain protein H1Y02_RS03570 ENOG4105I7R Adenylate cyclase H1Y02_RS03575 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) H1Y02_RS03595 ENOG4105W0Z cytoplasmic protein H1Y02_RS03610 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H1Y02_RS03615 ENOG4106032 Glutathionylspermidine synthase H1Y02_RS03620 ENOG4105F1G UPF0441 protein H1Y02_RS03625 ENOG4105DFG type I secretion outer membrane protein H1Y02_RS03630 ENOG41087AY ADP-Ribose pyrophosphatase H1Y02_RS03635 ENOG4108SX3 cytoplasmic protein H1Y02_RS03640 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H1Y02_RS03645 ENOG4105IPS esterase H1Y02_RS03650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H1Y02_RS03655 ENOG4105VRH Antibiotic biosynthesis monooxygenase H1Y02_RS03660 ENOG4105NF4 modulator of drug activity H1Y02_RS03665 ENOG4105DHQ Histidine kinase H1Y02_RS03670 ENOG4105XJC Two component transcriptional regulator (Winged helix family H1Y02_RS03675 ENOG4105H4F exported protein H1Y02_RS03680 ENOG4105F4I Transcriptional regulator H1Y02_RS03685 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H1Y02_RS03690 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase H1Y02_RS03695 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) H1Y02_RS03700 ENOG4105CCT upf0313 protein H1Y02_RS03705 ENOG4105CV8 reductase H1Y02_RS03710 ENOG4108I6A alcohol dehydrogenase H1Y02_RS03715 ENOG4105CF7 AraC family transcriptional regulator H1Y02_RS03720 ENOG4108K81 inner membrane protein YghB H1Y02_RS03725 ENOG4105C28 cystathionine H1Y02_RS03730 ENOG4105CWK Biopolymer transport protein, ExbB H1Y02_RS03735 ENOG4108ZZF transport protein (ExbD) H1Y02_RS03740 ENOG4108TEB UPF0114 protein H1Y02_RS03750 ENOG410900S Protein of unknown function (DUF2623) H1Y02_RS03755 ENOG4105CYM Glutathione S-transferase H1Y02_RS03770 ENOG4106032 Glutathionylspermidine synthase H1Y02_RS03775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H1Y02_RS03795 ENOG4105CC0 LysR family Transcriptional regulator H1Y02_RS03800 ENOG4105C28 cystathionine H1Y02_RS03815 ENOG4108UQV Membrane H1Y02_RS03820 ENOG4105CXN decarboxylase H1Y02_RS03825 ENOG4105EAA nucleoside H1Y02_RS03830 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division H1Y02_RS03835 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) H1Y02_RS03840 ENOG4105CEN a g-specific adenine glycosylase H1Y02_RS03845 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H1Y02_RS03850 ENOG41090ED Protein with unknown function (DUF469) H1Y02_RS03855 ENOG4105K33 Periplasmic Protein H1Y02_RS03860 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H1Y02_RS03865 ENOG41069H7 transport system small permease component H1Y02_RS03870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H1Y02_RS03875 ENOG4105CSA Coproporphyrinogen iii oxidase H1Y02_RS03880 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H1Y02_RS03885 ENOG4105VZ9 UPF0235 protein H1Y02_RS03890 ENOG4108VIA integral membrane protein H1Y02_RS03895 ENOG4105DFA alanine racemase domain protein H1Y02_RS03900 ENOG4105CZX twitching motility protein H1Y02_RS03905 ENOG41086KC Transcriptional regulator H1Y02_RS03910 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H1Y02_RS03915 ENOG4108UJU UPF0301 protein H1Y02_RS03920 ENOG4105D7Z glutathione synthase H1Y02_RS03925 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H1Y02_RS03930 ENOG4105RWS endonuclease I H1Y02_RS03940 ENOG4107QNK )-transporter H1Y02_RS03945 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H1Y02_RS03965 ENOG4105CYW agmatinase H1Y02_RS03990 ENOG4105CHR reductase H1Y02_RS03995 ENOG4108FUF Transcriptional regulator, IclR family H1Y02_RS04025 ENOG4105CHR reductase H1Y02_RS04030 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) H1Y02_RS04045 ENOG4105J5J Outer membrane porin H1Y02_RS04050 ENOG4108K0D peptidase, M48 H1Y02_RS04055 ENOG4105CV1 Transketolase (EC 2.2.1.1) H1Y02_RS04070 ENOG4105D2N Aldolase H1Y02_RS04075 ENOG4105D64 Mechanosensitive ion channel H1Y02_RS04085 ENOG4105MPN Membrane H1Y02_RS04090 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) H1Y02_RS04095 ENOG4105E66 phosphoriboisomerase A H1Y02_RS04100 ENOG4108JQ1 Dehydrogenase H1Y02_RS04105 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H1Y02_RS04120 ENOG4105E07 UPF0149 protein H1Y02_RS04125 ENOG4107RAQ aminopeptidase H1Y02_RS04130 ENOG4105D0A hydroxylase H1Y02_RS04135 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H1Y02_RS04140 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H1Y02_RS04145 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) H1Y02_RS04155 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H1Y02_RS04160 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H1Y02_RS04180 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS04185 ENOG4108Q3X Transcriptional regulator H1Y02_RS04190 ENOG4105N5Z UPF0267 protein H1Y02_RS04195 ENOG4108UT2 hemolysin iii H1Y02_RS04205 ENOG4105Y75 tpr repeat protein H1Y02_RS04210 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB H1Y02_RS04215 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) H1Y02_RS04220 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Y02_RS04225 ENOG4105T95 Thiol disulfide interChange protein H1Y02_RS04230 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H1Y02_RS04240 ENOG4105CRK lysyL-tRNA synthetase H1Y02_RS04245 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) H1Y02_RS04250 ENOG4108K5P (LipO)protein H1Y02_RS04260 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Y02_RS04275 ENOG4105CPC Aldo Keto reductase H1Y02_RS04290 ENOG4105W7K Transcriptional regulator H1Y02_RS04315 ENOG4107R5R arsenical pump membrane protein H1Y02_RS04320 ENOG4105K89 arsenate reductase H1Y02_RS04325 ENOG4105DUX Transporter H1Y02_RS04330 ENOG4105V2F Uncharacterized protein yoac H1Y02_RS04335 ENOG4105ETP RND efflux system, outer membrane lipoprotein H1Y02_RS04340 ENOG4108MI0 Resistance protein H1Y02_RS04345 ENOG4105J12 Multidrug resistance protein mdtN H1Y02_RS04355 ENOG4105VR1 Pfam:DUF1271 H1Y02_RS04360 ENOG410830R acetyltransferase H1Y02_RS04370 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin H1Y02_RS04375 ENOG4108T65 Fimbrial H1Y02_RS04380 ENOG4108SQA Fimbrial H1Y02_RS04385 ENOG4105CW0 outer membrane usher protein H1Y02_RS04390 ENOG4108NAE Fimbrial chaperone protein H1Y02_RS04395 ENOG4108S54 Fimbrial protein H1Y02_RS04400 ENOG4108RQP Major type 1 subunit fimbrin H1Y02_RS04405 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off H1Y02_RS04410 ENOG4108W9T type 1 fimbriae regulatory protein H1Y02_RS04425 ENOG4105D7X high-affinity nickel-transporter H1Y02_RS04430 ENOG4108ZT1 Transcriptional regulator H1Y02_RS04435 ENOG4108KTG Membrane protein, drug metabolite transporter H1Y02_RS04445 ENOG4108T1W Fimbrial subunit type 3 H1Y02_RS04485 ENOG4107S5I aldo keto reductase H1Y02_RS04490 ENOG4108MHD transport protein H1Y02_RS04500 ENOG4105C5Q Transcriptional regulator H1Y02_RS04505 ENOG4105CHU acetyl-coa acetyltransferase H1Y02_RS04510 ENOG4108QGT oligogalacturonate-specific porin H1Y02_RS04515 ENOG4105CAZ oligogalacturonide lyase H1Y02_RS04520 ENOG4105CHR reductase H1Y02_RS04525 ENOG4107QNK )-transporter H1Y02_RS04530 ENOG4106NDP Transcriptional regulator H1Y02_RS04540 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) H1Y02_RS04545 ENOG4108HKT sucrose-6-phosphate hydrolase H1Y02_RS04560 ENOG4108IJ9 (ABC) transporter H1Y02_RS04565 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component H1Y02_RS04570 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component H1Y02_RS04575 ENOG4105YKW H1Y02_RS04585 ENOG4105RQF LysR family Transcriptional regulator H1Y02_RS04595 ENOG4105DDV Transcriptional regulator (LacI family H1Y02_RS04600 ENOG4105CK1 PTS System H1Y02_RS04605 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS04610 ENOG4107YCY Transcriptional regulator H1Y02_RS04620 ENOG41060NJ transcriptional regulator H1Y02_RS04630 ENOG4107S74 Lysophospholipid transporter LplT H1Y02_RS04635 ENOG4105CPC Aldo Keto reductase H1Y02_RS04640 ENOG4105SUV lipoprotein YgdR H1Y02_RS04645 ENOG4105EE5 Membrane protein terC H1Y02_RS04650 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) H1Y02_RS04665 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase H1Y02_RS04670 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) H1Y02_RS04675 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H1Y02_RS04680 ENOG4105IPU prepilin peptidase dependent protein A H1Y02_RS04685 ENOG4105JCS prepilin peptidase dependent protein H1Y02_RS04690 ENOG4105SEN Protein of unknown function (DUF2509) H1Y02_RS04695 ENOG4105RVB Prepilin peptidase dependent protein c H1Y02_RS04700 ENOG4105DSY exodeoxyribonuclease V, gamma H1Y02_RS04705 ENOG4107QXK peptidase H1Y02_RS04710 ENOG4107QKA exodeoxyribonuclease V beta H1Y02_RS04715 ENOG4107QYX exodeoxyribonuclease v alpha H1Y02_RS04725 ENOG4107QZM n-acetylglutamate synthase H1Y02_RS04730 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H1Y02_RS04735 ENOG4107QZB decarboxylase H1Y02_RS04740 ENOG4105JZC GHMP kinase H1Y02_RS04750 ENOG4105KTW ethanolamine utilization protein H1Y02_RS04755 ENOG4105M3W utilization protein H1Y02_RS04765 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) H1Y02_RS04770 ENOG4105C0A alcohol dehydrogenase H1Y02_RS04775 ENOG4108EKI Dehydrogenase H1Y02_RS04785 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml H1Y02_RS04795 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) H1Y02_RS04805 ENOG4105KNY Microcompartments protein H1Y02_RS04815 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit H1Y02_RS04820 ENOG4108ZFT Dehydratase small subunit H1Y02_RS04825 ENOG4105YCI dehydratase medium subunit H1Y02_RS04830 ENOG4105DMB glycerol dehydratase H1Y02_RS04835 ENOG4105EHR propanediol utilization protein pduB H1Y02_RS04840 ENOG4105KNY Microcompartments protein H1Y02_RS04845 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H1Y02_RS04850 ENOG4107XVH Transcriptional regulator H1Y02_RS04855 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) H1Y02_RS04860 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) H1Y02_RS04865 ENOG41081F0 Precorrin-8x methylmutase H1Y02_RS04870 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) H1Y02_RS04875 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase H1Y02_RS04880 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase H1Y02_RS04885 ENOG4105CIA precorrin-4 C(11)-methyltransferase H1Y02_RS04890 ENOG4108P62 biosynthesis protein (CbiG) H1Y02_RS04895 ENOG4105E4R Precorrin-3B C17-methyltransferase H1Y02_RS04900 ENOG4105QUC reductase H1Y02_RS04905 ENOG4107PPM cobalt chelatase H1Y02_RS04910 ENOG4105DVK Precorrin-2 c20-methyltransferase H1Y02_RS04915 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) H1Y02_RS04920 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) H1Y02_RS04925 ENOG4108V4M Cobalt abc transporter H1Y02_RS04940 ENOG4108YZT Adenosylcobinamide kinase H1Y02_RS04965 ENOG4105CA3 membrane-bound lytic murein transglycosylase H1Y02_RS04970 ENOG4105CUZ uba thif-type nad fad binding protein H1Y02_RS04975 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) H1Y02_RS04980 ENOG4105C9B Cysteine desulfurase H1Y02_RS04985 ENOG4105M5B (LipO)protein H1Y02_RS04990 ENOG4105ETT transcriptional Regulator, LysR family H1Y02_RS04995 ENOG4105M08 Membrane H1Y02_RS05005 ENOG4107EDW L-fucose operon activator H1Y02_RS05010 ENOG4105NWF RbsD or FucU transport H1Y02_RS05015 ENOG4105CMG Carbohydrate kinase H1Y02_RS05025 ENOG4105EDR glucose galactose transporter H1Y02_RS05030 ENOG4107W7X Aldolase H1Y02_RS05035 ENOG4105C0A alcohol dehydrogenase H1Y02_RS05040 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease H1Y02_RS05045 ENOG4108JU7 Transcriptional regulator H1Y02_RS05050 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) H1Y02_RS05065 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS05070 ENOG4108UMI ABC transporter, permease H1Y02_RS05075 ENOG4105D01 (LipO)protein H1Y02_RS05080 ENOG41079KZ Major Facilitator Superfamily H1Y02_RS05090 ENOG4105GVF (ABC) transporter H1Y02_RS05095 ENOG4105EJQ L-serine dehydratase H1Y02_RS05100 ENOG4105C44 Serine transporter H1Y02_RS05105 ENOG4105EWT decarboxylase family H1Y02_RS05115 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) H1Y02_RS05130 ENOG4105DJB Major Facilitator Superfamily H1Y02_RS05135 ENOG4105EQX glucarate dehydratase H1Y02_RS05140 ENOG4105EQX glucarate dehydratase H1Y02_RS05145 ENOG4105BZW Glycerate kinase H1Y02_RS05150 ENOG4105BZU Histidine kinase H1Y02_RS05160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H1Y02_RS05165 ENOG4105DXN mazG family H1Y02_RS05175 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H1Y02_RS05185 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H1Y02_RS05190 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase H1Y02_RS05195 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H1Y02_RS05200 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H1Y02_RS05205 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) H1Y02_RS05210 ENOG4108MXK alkaline phosphatase isozyme conversion H1Y02_RS05215 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H1Y02_RS05220 ENOG4105C11 sulfate adenylyltransferase), subunit 2 H1Y02_RS05230 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) H1Y02_RS05235 ENOG4105N0Z inner membrane protein ygbE H1Y02_RS05240 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H1Y02_RS05245 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) H1Y02_RS05250 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) H1Y02_RS05255 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) H1Y02_RS05265 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) H1Y02_RS05270 ENOG4108K5P (LipO)protein H1Y02_RS05275 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Y02_RS05300 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H1Y02_RS05305 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H1Y02_RS05310 ENOG4105KZM cytoplasmic protein H1Y02_RS05320 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) H1Y02_RS05335 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS05340 ENOG4105EHG Permease protein H1Y02_RS05345 ENOG4107R4I Periplasmic binding protein H1Y02_RS05350 ENOG4106QJH hemin transport protein H1Y02_RS05365 ENOG4105VXR cytoplasmic protein H1Y02_RS05370 ENOG4105CC5 ABC transporter H1Y02_RS05375 ENOG4105CC5 ABC transporter H1Y02_RS05380 ENOG4105DIK (ABC) transporter H1Y02_RS05390 ENOG4105DDV Transcriptional regulator (LacI family H1Y02_RS05395 ENOG4105DKQ ROK family H1Y02_RS05400 ENOG4105VCP PTS System H1Y02_RS05405 ENOG4105CK1 PTS System H1Y02_RS05410 ENOG4105VZJ PTS System H1Y02_RS05415 ENOG4105CK1 PTS System H1Y02_RS05420 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) H1Y02_RS05430 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS05440 ENOG4105C45 hydrogenase expression formation protein (HypE) H1Y02_RS05445 ENOG4105CQS hydrogenase expression formation protein HypD H1Y02_RS05450 ENOG41083WG hydrogenase assembly chaperone H1Y02_RS05455 ENOG4107RSS Hydrogenase accessory protein HypB H1Y02_RS05460 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) H1Y02_RS05465 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA H1Y02_RS05470 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) H1Y02_RS05475 ENOG4107R30 NADH dehydrogenase H1Y02_RS05480 ENOG4107TDF Formate hydrogenlyase subunit 4 H1Y02_RS05485 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H1Y02_RS05490 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit H1Y02_RS05495 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit H1Y02_RS05500 ENOG4105I6X formate hydrogenlyase maturation H1Y02_RS05505 ENOG4108MG9 hydrogenase 3 maturation protease H1Y02_RS05515 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS05520 ENOG4105C5Y PTS System H1Y02_RS05525 ENOG4105DDV Transcriptional regulator (LacI family H1Y02_RS05530 ENOG4108RC0 Electron transport protein H1Y02_RS05535 ENOG4105C8H hydrogenase maturation protein Hypf H1Y02_RS05550 ENOG4107258 Transcriptional regulator H1Y02_RS05555 ENOG4105JSC dimethylmenaquinone methyltransferase H1Y02_RS05570 ENOG4105CNW domain protein H1Y02_RS05575 ENOG4108JUA Transcriptional regulator H1Y02_RS05585 ENOG410804X Transcriptional regulator H1Y02_RS05590 ENOG4105J92 DNA-binding transcriptional activator GutM H1Y02_RS05595 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase H1Y02_RS05600 ENOG4105VI0 Pts system, glucitol sorbitol-specific H1Y02_RS05605 ENOG4105DZY Pts system, glucitol sorbitol-specific H1Y02_RS05610 ENOG410787A Pts system, glucitol sorbitol-specific H1Y02_RS05615 ENOG4105CVE Lytic murein transglycosylase H1Y02_RS05625 ENOG4105CC5 ABC transporter H1Y02_RS05630 ENOG4105DSE periplasmic solute binding protein H1Y02_RS05635 ENOG4107TH8 cina domain protein H1Y02_RS05650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H1Y02_RS05655 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) H1Y02_RS05685 ENOG4105K3G Periplasmic Protein H1Y02_RS05690 ENOG4107VXZ Hydrolase H1Y02_RS05695 ENOG4105W39 Membrane H1Y02_RS05700 ENOG4105D9M gamma-glutamylcysteine synthetase H1Y02_RS05715 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H1Y02_RS05720 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Y02_RS05725 ENOG4105CW7 secretion protein, HlyD family H1Y02_RS05730 ENOG4105NTK Transcriptional repressor Mpra H1Y02_RS05735 ENOG4105ZED uncharacterized protein ygaH H1Y02_RS05740 ENOG4108UMN azlc family H1Y02_RS05745 ENOG4105GIJ Glycine betaine H1Y02_RS05750 ENOG4108HQS Glycine betaine H1Y02_RS05755 ENOG4108IJ7 Glycine betaine H1Y02_RS05760 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H1Y02_RS05765 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H1Y02_RS05775 ENOG4105WAZ (Glutaredoxin-like protein) NrdH H1Y02_RS05780 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H1Y02_RS05790 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) H1Y02_RS05795 ENOG4108WMJ Protein of unknown function (DUF2002) H1Y02_RS05800 ENOG4108RNS Exports L-alanine (By similarity) H1Y02_RS05805 ENOG4108X73 DNA- binding protein H1Y02_RS05820 ENOG4108V62 Rhodanese domain protein H1Y02_RS05825 ENOG41080HT Transcriptional regulator, arsr family H1Y02_RS05835 ENOG4105CC0 LysR family Transcriptional regulator H1Y02_RS05840 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H1Y02_RS05845 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family H1Y02_RS05850 ENOG4105C26 Dehydrogenase H1Y02_RS05855 ENOG4105X0I Fimbrial H1Y02_RS05860 ENOG4105F2I Transposase H1Y02_RS05895 ENOG4105ZTC transcriptional activator, Ogr delta H1Y02_RS05915 ENOG4105DFP Integrase H1Y02_RS05925 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H1Y02_RS05930 ENOG4108Z1B Cyclase dehydrase H1Y02_RS05940 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H1Y02_RS05945 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H1Y02_RS05950 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H1Y02_RS05955 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H1Y02_RS05960 ENOG4108JU6 CBS domain protein H1Y02_RS05965 ENOG4106KVJ cytochrome C assembly protein H1Y02_RS05970 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY H1Y02_RS05975 ENOG4105K5M 30s ribosomal protein S16 H1Y02_RS05980 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) H1Y02_RS05985 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) H1Y02_RS05990 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H1Y02_RS06005 ENOG41090EK ompa motb domain protein H1Y02_RS06010 ENOG4108KHX Diguanylate cyclase H1Y02_RS06015 ENOG4108WS1 H1Y02_RS06020 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H1Y02_RS06025 ENOG4105EHE chorismate mutase- prephenate dehydrogenase H1Y02_RS06035 ENOG4105CQC Prephenate dehydratase H1Y02_RS06045 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA H1Y02_RS06050 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H1Y02_RS06055 ENOG4105C34 Pseudouridine synthase H1Y02_RS06060 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H1Y02_RS06065 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H1Y02_RS06095 ENOG4105CSH Transporter H1Y02_RS06100 ENOG4105T42 (LipO)protein H1Y02_RS06105 ENOG4105JIM Phosphatidylserine synthase H1Y02_RS06110 ENOG4105CD5 CoA-binding domain protein H1Y02_RS06115 ENOG4106IUH DTW domain containing protein H1Y02_RS06120 ENOG4105K63 Thioredoxin H1Y02_RS06125 ENOG4105EIB trna rrna methyltransferase H1Y02_RS06135 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) H1Y02_RS06140 ENOG4105C1J atp-dependent rna helicase H1Y02_RS06145 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) H1Y02_RS06150 ENOG4108IYU L-aspartate oxidase H1Y02_RS06165 ENOG41069PW sigma-e factor negative regulatory protein H1Y02_RS06170 ENOG4105VQK sigma E regulatory protein, MucB RseB H1Y02_RS06175 ENOG4105WMJ Positive regulator of sigma E, RseC MucC H1Y02_RS06180 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H1Y02_RS06185 ENOG4105C3F Signal peptidase i H1Y02_RS06190 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H1Y02_RS06195 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H1Y02_RS06200 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) H1Y02_RS06205 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) H1Y02_RS06210 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) H1Y02_RS06215 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H1Y02_RS06220 ENOG4106G6Q Transcriptional regulator H1Y02_RS06225 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB H1Y02_RS06230 ENOG4108Z6B deaminase H1Y02_RS06235 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) H1Y02_RS06240 ENOG4108ETH Formylglycinamide ribotide synthetase H1Y02_RS06245 ENOG4107WP9 Histidine kinase H1Y02_RS06250 ENOG4108SKK alpha helix protein H1Y02_RS06255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H1Y02_RS06260 ENOG4108YZA Nitrogen regulatory protein pii H1Y02_RS06265 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H1Y02_RS06270 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H1Y02_RS06275 ENOG4108SB3 DoxX Family H1Y02_RS06280 ENOG4105D8G Major Facilitator superfamily H1Y02_RS06285 ENOG4108MN2 Stationary phase inducible protein CsiE H1Y02_RS06290 ENOG41065CD Exported protein H1Y02_RS06295 ENOG4105D7X high-affinity nickel-transporter H1Y02_RS06305 ENOG4105ECY inositol monophosphatase H1Y02_RS06310 ENOG4105CVS RNA methyltransferase TrmH family, group 1 H1Y02_RS06315 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H1Y02_RS06320 ENOG4105C3J Cysteine desulfurase H1Y02_RS06325 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins H1Y02_RS06330 ENOG4108Z4V iron-sulfur cluster assembly H1Y02_RS06335 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) H1Y02_RS06340 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB H1Y02_RS06345 ENOG4108ZIT Ferredoxin, 2FE-2S H1Y02_RS06350 ENOG4105WVQ Fe-S assembly protein IscX H1Y02_RS06355 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H1Y02_RS06360 ENOG4105YYA enhanced serine sensitivity protein SseB H1Y02_RS06375 ENOG4105KHC sulfurtransferase H1Y02_RS06380 ENOG4105DN3 alpha-2-macroglobulin domain protein H1Y02_RS06385 ENOG4108JQB penicillin-binding protein 1C H1Y02_RS06390 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H1Y02_RS06395 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H1Y02_RS06405 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) H1Y02_RS06415 ENOG4105N21 Membrane H1Y02_RS06420 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H1Y02_RS06425 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H1Y02_RS06435 ENOG4105VPD cellular component movement H1Y02_RS06440 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H1Y02_RS06445 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H1Y02_RS06450 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H1Y02_RS06465 ENOG41062G3 Protein of unknown function (DUF2633) H1Y02_RS06470 ENOG4105BZU Histidine kinase H1Y02_RS06475 ENOG4105C9X ppx gppa phosphatase H1Y02_RS06480 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H1Y02_RS06485 ENOG4108V3E phosphoribosylglycinamide formyltransferase H1Y02_RS06495 ENOG41066F8 ROK family H1Y02_RS06500 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS06510 ENOG4105C2W permease H1Y02_RS06515 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) H1Y02_RS06525 ENOG4105K89 arsenate reductase H1Y02_RS06530 ENOG4105ERG peptidase m48, ste24p H1Y02_RS06540 ENOG4105C02 permease H1Y02_RS06545 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H1Y02_RS06550 ENOG4105RH4 Glycine cleavage system transcriptional repressor H1Y02_RS06555 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H1Y02_RS06560 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H1Y02_RS06565 ENOG4105C8V SAICAR synthetase H1Y02_RS06570 ENOG4105CGZ zinc metallopeptidase H1Y02_RS06575 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) H1Y02_RS06580 ENOG4106KED esterase YpfH H1Y02_RS06585 ENOG4105XYK UPF0370 protein H1Y02_RS06595 ENOG4105KUZ arsenate reductase H1Y02_RS06605 ENOG4105BZS acriflavin resistance protein H1Y02_RS06615 ENOG4107VIJ nudix hydrolase H1Y02_RS06620 ENOG4108PVD exported protein H1Y02_RS06625 ENOG4105CV1 Transketolase (EC 2.2.1.1) H1Y02_RS06630 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H1Y02_RS06635 ENOG4105C6K Malic enzyme H1Y02_RS06640 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) H1Y02_RS06645 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase H1Y02_RS06650 ENOG4108R6G acetyltransferase H1Y02_RS06655 ENOG4105QZU Inner membrane protein YfeZ H1Y02_RS06660 ENOG4105E7K (LipO)protein H1Y02_RS06665 ENOG4105EZR dyp-type peroxidase family protein H1Y02_RS06670 ENOG4105WDY DNA (cytosine-5-)-methyltransferase H1Y02_RS06675 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein H1Y02_RS06680 ENOG4108I5D sulfate abc transporter H1Y02_RS06685 ENOG4105ECW sulfate abc transporter H1Y02_RS06690 ENOG4108IJ6 ABC transporter H1Y02_RS06695 ENOG4105C6T cysteine synthase H1Y02_RS06700 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein H1Y02_RS06705 ENOG4105CSW GntR family transcriptional regulator H1Y02_RS06710 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) H1Y02_RS06720 ENOG4105C5Y PTS System H1Y02_RS06725 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H1Y02_RS06730 ENOG4105KZ7 phosphocarrier protein hpr H1Y02_RS06735 ENOG4105C6T cysteine synthase H1Y02_RS06740 ENOG4105EXN Sulfate transport protein CysZ H1Y02_RS06745 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) H1Y02_RS06755 ENOG4105VRT cytoplasmic protein H1Y02_RS06760 ENOG4105DHU Bile acid H1Y02_RS06765 ENOG4108M0I Transcriptional regulator H1Y02_RS06800 ENOG4105GXM Putative transcription regulator (DUF1323) H1Y02_RS06805 ENOG4105HZG regulatoR H1Y02_RS06820 ENOG4108KMM Diguanylate cyclase H1Y02_RS06825 ENOG4105D9N nucleoside H1Y02_RS06830 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) H1Y02_RS06835 ENOG4109076 Conserved Protein H1Y02_RS06840 ENOG4105CPC Aldo Keto reductase H1Y02_RS06845 ENOG4107RA9 decarboxylase H1Y02_RS06855 ENOG4105CHC glucokinase (EC 2.7.1.2) H1Y02_RS06860 ENOG4105DY9 regulatoR H1Y02_RS06865 ENOG4108HRK Histidine kinase H1Y02_RS06875 ENOG4105CHM Aminotransferase H1Y02_RS06885 ENOG4105DJ2 Major Facilitator Superfamily H1Y02_RS06890 ENOG4107Y2X deaminase H1Y02_RS06895 ENOG4105DND Transcriptional regulator H1Y02_RS06910 ENOG4105BZU Histidine kinase H1Y02_RS06920 ENOG4105DFP Integrase H1Y02_RS06930 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS06940 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS06950 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS06960 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS06980 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS06990 ENOG4105F2I Transposase H1Y02_RS07000 ENOG4105EKQ RNA-directed DNA polymerase H1Y02_RS07010 ENOG4105S64 Formate nitrite transporter H1Y02_RS07015 ENOG410903C (LipO)protein H1Y02_RS07025 ENOG4105F2I Transposase H1Y02_RS07035 ENOG4105KZW UPF0381 protein H1Y02_RS07040 ENOG4105CHU acetyl-coa acetyltransferase H1Y02_RS07050 ENOG4108BY2 phosphohistidine phosphatase H1Y02_RS07060 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) H1Y02_RS07065 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H1Y02_RS07075 ENOG4105EJ9 Membrane H1Y02_RS07080 ENOG4108BPE -transporting atpase H1Y02_RS07085 ENOG4105MH2 YfcL protein H1Y02_RS07090 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) H1Y02_RS07095 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H1Y02_RS07100 ENOG4105F9N Major Facilitator Superfamily H1Y02_RS07105 ENOG4106WZ1 flagella biosynthesis regulator H1Y02_RS07115 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H1Y02_RS07120 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H1Y02_RS07125 ENOG4105DQR SNARE associated Golgi H1Y02_RS07130 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) H1Y02_RS07135 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H1Y02_RS07140 ENOG4108S3P Sporulation domain protein H1Y02_RS07145 ENOG4105E96 Colicin v production protein H1Y02_RS07150 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H1Y02_RS07155 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H1Y02_RS07165 ENOG4105E89 ABC transporter H1Y02_RS07170 ENOG4105E89 ABC transporter H1Y02_RS07175 ENOG4105DSP amino acid AbC transporter H1Y02_RS07180 ENOG4106YG3 ABC transporter H1Y02_RS07185 ENOG4108JEH abc transporter atp-binding protein H1Y02_RS07190 ENOG4105KNA -acetyltransferase H1Y02_RS07200 ENOG4105ECP epimerase H1Y02_RS07205 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase H1Y02_RS07210 ENOG4105CYM Glutathione S-transferase H1Y02_RS07215 ENOG4108SHQ Glutathione S-transferase H1Y02_RS07220 ENOG4108RE9 Phosphodiesterase H1Y02_RS07225 ENOG4105PTV Nudix Hydrolase H1Y02_RS07230 ENOG4105C6K Malic enzyme H1Y02_RS07235 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H1Y02_RS07240 ENOG4105PQ6 UPF0208 membrane protein H1Y02_RS07250 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 H1Y02_RS07255 ENOG4107QWE )-transporter H1Y02_RS07260 ENOG4105DK2 UPF0207 protein H1Y02_RS07265 ENOG4105CHM Aminotransferase H1Y02_RS07270 ENOG4105F2I Transposase H1Y02_RS07275 ENOG4107NQ8 LysR family Transcriptional regulator H1Y02_RS07280 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H1Y02_RS07285 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H1Y02_RS07290 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H1Y02_RS07295 ENOG4105GKE subunit e H1Y02_RS07300 ENOG4107QIZ NADH dehydrogenase H1Y02_RS07305 ENOG4108IEH NADH dehydrogenase subunit g H1Y02_RS07310 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H1Y02_RS07320 ENOG4107UFS subunit j H1Y02_RS07325 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H1Y02_RS07330 ENOG4105D65 subunit l H1Y02_RS07335 ENOG4105C8S subunit m H1Y02_RS07345 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H1Y02_RS07350 ENOG4107YB6 acetyltransferase, (GNAT) family H1Y02_RS07355 ENOG4105E4F Isochorismate synthase H1Y02_RS07370 ENOG4108IPT Naphthoate synthase H1Y02_RS07380 ENOG4105CEY Amp-dependent synthetase and ligase H1Y02_RS07405 ENOG4105DHQ Histidine kinase H1Y02_RS07415 ENOG4108UII YfaZ family H1Y02_RS07420 ENOG4108EWA cinA-like protein H1Y02_RS07425 ENOG4107258 Transcriptional regulator H1Y02_RS07435 ENOG4105CSP Major Facilitator Superfamily H1Y02_RS07440 ENOG4105CNV Aldolase H1Y02_RS07445 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H1Y02_RS07450 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B H1Y02_RS07455 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A H1Y02_RS07460 ENOG4105CXY transporter H1Y02_RS07465 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H1Y02_RS07470 ENOG4105XPH Ferredoxin H1Y02_RS07475 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H1Y02_RS07480 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H1Y02_RS07485 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H1Y02_RS07490 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H1Y02_RS07495 ENOG4105BZU Histidine kinase H1Y02_RS07500 ENOG41068CG regulatoR H1Y02_RS07505 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC H1Y02_RS07520 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H1Y02_RS07525 ENOG4105CF1 Alkylated DNA repair protein H1Y02_RS07530 ENOG4105IBP Cyclic peptide transporter H1Y02_RS07535 ENOG4105CJW magnesium transporter H1Y02_RS07540 ENOG4105CHH sulfate transporter H1Y02_RS07560 ENOG4105F4G Membrane H1Y02_RS07570 ENOG4105E68 Sulfatase H1Y02_RS07575 ENOG4105PAN UPF0352 protein H1Y02_RS07580 ENOG4106V8H Nucleoid-associated protein H1Y02_RS07585 ENOG4105N2W Transcriptional regulator H1Y02_RS07590 ENOG4107VIJ nudix hydrolase H1Y02_RS07610 ENOG4105CFI type iii restriction protein res subunit H1Y02_RS07615 ENOG4105I08 Pseudouridine synthase H1Y02_RS07620 ENOG4105C2C drug resistance transporter, Bcr CflA H1Y02_RS07625 ENOG4105HG6 H1Y02_RS07630 ENOG4108JQ5 ABC transporter H1Y02_RS07635 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component H1Y02_RS07640 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component H1Y02_RS07645 ENOG4105E43 Extracellular solute-binding protein, family 5 H1Y02_RS07650 ENOG4105CXC rtn protein H1Y02_RS07655 ENOG4107TT5 NLP P60 protein H1Y02_RS07660 ENOG41076MN Phosphoesterase, PA-phosphatase related H1Y02_RS07665 ENOG4105CKI cobalamin synthesis protein H1Y02_RS07670 ENOG4105DEI Mannitol dehydrogenase H1Y02_RS07675 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) H1Y02_RS07685 ENOG4105KRS Proteinase inhibitor H1Y02_RS07690 ENOG4105EGI Transcriptional regulator H1Y02_RS07695 ENOG4105KK7 inner membrane protein YiaW H1Y02_RS07700 ENOG4105EFX secretion protein, HlyD family H1Y02_RS07705 ENOG4105S8Q sugar efflux transporter H1Y02_RS07710 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein H1Y02_RS07715 ENOG4105DE4 1-phosphofructokinase H1Y02_RS07720 ENOG4105DM4 PTS System H1Y02_RS07725 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) H1Y02_RS07730 ENOG4105HMI Membrane H1Y02_RS07735 ENOG4105DUM transcriptional regulator, lysR family H1Y02_RS07740 ENOG4108IQI permease H1Y02_RS07745 ENOG4105D05 Receptor H1Y02_RS07760 ENOG4105DHF Membrane H1Y02_RS07765 ENOG41060NJ transcriptional regulator H1Y02_RS07775 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS07785 ENOG4105C2J ABC transporter H1Y02_RS07790 ENOG4107SDZ Galactoside transport system permease protein mglC H1Y02_RS07795 ENOG4107GZ4 SanA protein H1Y02_RS07800 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) H1Y02_RS07805 ENOG41067MG lrgb family H1Y02_RS07815 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) H1Y02_RS07820 ENOG4105TW1 Carbohydrate-selective porin OprB H1Y02_RS07835 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS07840 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H1Y02_RS07850 ENOG4105KHU inner membrane protein YohD H1Y02_RS07855 ENOG41069YE inner membrane protein yohC H1Y02_RS07860 ENOG41061WM D-Alanyl-D-Alanine H1Y02_RS07870 ENOG4105CXG d-lactate dehydrogenase H1Y02_RS07875 ENOG4107QK4 glycoside hydrolase, family 3 domain protein H1Y02_RS07880 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system H1Y02_RS07885 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component H1Y02_RS07890 ENOG4108IJ8 ABC transporter H1Y02_RS07895 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component H1Y02_RS07905 ENOG4108HRK Histidine kinase H1Y02_RS07910 ENOG4108NEV two component transcriptional regulator, LytTR family H1Y02_RS07915 ENOG4108W15 Protein of unknown function (DUF1456) H1Y02_RS07920 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H1Y02_RS07925 ENOG4105D1F ATP-binding protein H1Y02_RS07935 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly H1Y02_RS07940 ENOG4105CBN LysR family transcriptional regulator H1Y02_RS07945 ENOG4105C7N Xanthine uracil vitamin C permease H1Y02_RS07955 ENOG4105DUM transcriptional regulator, lysR family H1Y02_RS07970 ENOG4105DWF phosphomethylpyrimidine kinase H1Y02_RS07975 ENOG4105EIE fructose-bisphosphate aldolase H1Y02_RS07980 ENOG4105IE8 Alpha-ketoglutarate permease H1Y02_RS08000 ENOG4105DKT Transcriptional regulator H1Y02_RS08005 ENOG4105DEI Mannitol dehydrogenase H1Y02_RS08010 ENOG4105CMG Carbohydrate kinase H1Y02_RS08015 ENOG4105IE8 Alpha-ketoglutarate permease H1Y02_RS08020 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H1Y02_RS08025 ENOG4105CXK mandelate racemase muconate lactonizing H1Y02_RS08030 ENOG4105DEF Extracellular solute-binding protein, family 5 H1Y02_RS08035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Y02_RS08040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS08050 ENOG4108JQ7 (ABC) transporter H1Y02_RS08060 ENOG4105CFP Peptidase U32 H1Y02_RS08065 ENOG4105E3W Two component transcriptional regulator (Winged helix family H1Y02_RS08070 ENOG4105EB3 Histidine kinase H1Y02_RS08075 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Y02_RS08090 ENOG4105ENT Efflux transporter rnd family, mfp subunit H1Y02_RS08095 ENOG4105CK2 sodium dicarboxylate symporter H1Y02_RS08120 ENOG4105R8A Heat shock protein H1Y02_RS08125 ENOG4105D03 DNA-3-methyladenine glycosylase II H1Y02_RS08130 ENOG4105DBI uridine monophosphokinase H1Y02_RS08135 ENOG4105DHP deoxycytidine triphosphate deaminase H1Y02_RS08140 ENOG4108GAE asmA family H1Y02_RS08145 ENOG4105EE5 Membrane protein terC H1Y02_RS08150 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H1Y02_RS08155 ENOG4105MH5 phosphoesterase PA-phosphatase related protein H1Y02_RS08165 ENOG4108MRJ H1Y02_RS08170 ENOG4105DAY polysaccharide export protein H1Y02_RS08175 ENOG4105KJF protein tyrosine phosphatase H1Y02_RS08190 ENOG41090RK glycosyl transferase H1Y02_RS08230 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H1Y02_RS08270 ENOG4105C1B dTDP-glucose 4-6-dehydratase H1Y02_RS08280 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase H1Y02_RS08285 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H1Y02_RS08300 ENOG4105EY8 ABC transporter H1Y02_RS08310 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H1Y02_RS08315 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H1Y02_RS08325 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H1Y02_RS08330 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H1Y02_RS08335 ENOG4105CIH Imidazole acetol-phosphate transaminase H1Y02_RS08345 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H1Y02_RS08355 ENOG4107SRH Nad-dependent epimerase dehydratase H1Y02_RS08360 ENOG4105EQ1 Transcriptional regulator H1Y02_RS08370 ENOG4105CUB amino acid H1Y02_RS08375 ENOG4105YVS arsR family transcriptional regulator H1Y02_RS08380 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H1Y02_RS08385 ENOG4105CJB Exodeoxyribonuclease I H1Y02_RS08390 ENOG4105DZ1 carboxypeptidase H1Y02_RS08400 ENOG4105DR8 Membrane H1Y02_RS08405 ENOG41090HJ UPF0265 protein H1Y02_RS08410 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) H1Y02_RS08420 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) H1Y02_RS08430 ENOG41090U3 tautomerase H1Y02_RS08435 ENOG4105HEI LysR family (Transcriptional regulator H1Y02_RS08440 ENOG4108KMH lipoate-protein ligase a H1Y02_RS08445 ENOG4105CSH Transporter H1Y02_RS08455 ENOG4105BZU Histidine kinase H1Y02_RS08460 ENOG4108YS1 cytoplasmic protein H1Y02_RS08465 ENOG4105YP6 Domain of unknown function (DUF1869) H1Y02_RS08470 ENOG4105ETT transcriptional Regulator, LysR family H1Y02_RS08485 ENOG4105BZU Histidine kinase H1Y02_RS08500 ENOG4105UQX Mate efflux family protein H1Y02_RS08535 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS08570 ENOG4105FYV Amp nucleosidase H1Y02_RS08590 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H1Y02_RS08595 ENOG4108WUH Transcriptional regulator, TetR family H1Y02_RS08600 ENOG4105EEQ Na H antiporter H1Y02_RS08615 ENOG4107R11 Transcriptional regulator H1Y02_RS08620 ENOG4108PXI ErfK YbiS YcfS YnhG H1Y02_RS08630 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) H1Y02_RS08640 ENOG4105FCK Membrane H1Y02_RS08655 ENOG4105Y0K Inner membrane protein YedR H1Y02_RS08660 ENOG4105EST Metal Dependent Phosphohydrolase H1Y02_RS08665 ENOG4105DVF Cytosine-specific methyltransferase H1Y02_RS08670 ENOG41090BB DNA mismatch endonuclease (vsr) H1Y02_RS08675 ENOG4105FDR Membrane H1Y02_RS08680 ENOG4105CKW Inner membrane protein yedI H1Y02_RS08690 ENOG4105YX3 cellular response to acidity H1Y02_RS08705 ENOG4105JCU Inherit from NOG: (Lipo)protein H1Y02_RS08710 ENOG4105E5K Alpha-amylase H1Y02_RS08715 ENOG4105EAB amino acid AbC transporter H1Y02_RS08720 ENOG4105K6H D-cysteine desulfhydrase H1Y02_RS08725 ENOG4105E5Q amino acid AbC transporter H1Y02_RS08730 ENOG4105CDA abc transporter atp-binding protein H1Y02_RS08735 ENOG4105VJY transcriptional regulator H1Y02_RS08740 ENOG4105XVG cytoplasmic protein H1Y02_RS08745 ENOG4105F2I Transposase H1Y02_RS08750 ENOG4105WH1 Two component transcriptional regulator luxr family H1Y02_RS08790 ENOG4106RHG Yeca family H1Y02_RS08795 ENOG4105E0U tyrosine-specific transport protein H1Y02_RS08800 ENOG4105VVZ metal-binding protein H1Y02_RS08805 ENOG41090A1 ferritin H1Y02_RS08815 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Y02_RS08820 ENOG4105N4N Protein of unknown function (DUF2766) H1Y02_RS08835 ENOG4108UEC Ferritin-like protein H1Y02_RS08840 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator H1Y02_RS08850 ENOG4105CNN ABC, transporter H1Y02_RS08860 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase H1Y02_RS08865 ENOG4108VA4 Universal stress protein H1Y02_RS08870 ENOG4105CT4 transporter H1Y02_RS08875 ENOG4105F5H Glycosyl Hydrolase Family 88 H1Y02_RS08880 ENOG4105C75 arginyL-tRNA synthetase H1Y02_RS08885 ENOG4106ZCM YecM protein H1Y02_RS08890 ENOG4106N3A copper homeostasis protein cutc H1Y02_RS08905 ENOG4105WJG Glutathione H1Y02_RS08910 ENOG41081XQ Conserved Protein H1Y02_RS08915 ENOG4105D3W isochorismatase H1Y02_RS08920 ENOG4105C9M aspartyl-trna synthetase H1Y02_RS08925 ENOG4108TIT dATP pyrophosphohydrolase H1Y02_RS08930 ENOG4105CDY transcriptional regulatory protein H1Y02_RS08935 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) H1Y02_RS08940 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H1Y02_RS08945 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H1Y02_RS08950 ENOG4105FAV ABC, transporter H1Y02_RS08960 ENOG4105NXV High-affinity zinc uptake system protein H1Y02_RS08965 ENOG4105DR5 peptidase H1Y02_RS08970 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase H1Y02_RS08975 ENOG4108MRH transcriptional regulatory protein H1Y02_RS08980 ENOG4107R1I NAD-dependent malic enzyme H1Y02_RS08985 ENOG4105F2I Transposase H1Y02_RS08990 ENOG4105F2I Transposase H1Y02_RS09005 ENOG4105CA9 Pyruvate kinase H1Y02_RS09010 ENOG4106KNT transcriptional regulator H1Y02_RS09020 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H1Y02_RS09025 ENOG4105C01 Dihydroxy-acid dehydratase H1Y02_RS09030 ENOG4108UHU Aldolase H1Y02_RS09040 ENOG4105X2V dna damage-inducible protein H1Y02_RS09045 ENOG4108Q2J Inner membrane protein YebE H1Y02_RS09050 ENOG4105CUG Oligopeptidase b H1Y02_RS09055 ENOG4105UMD exodeoxyribonuclease X H1Y02_RS09060 ENOG4105MPK DNA polymerase III subunit theta H1Y02_RS09065 ENOG4105FXM Copper resistance protein H1Y02_RS09070 ENOG4108PNC copper resistance H1Y02_RS09075 ENOG4105NKT exported protein H1Y02_RS09085 ENOG4108MJ5 VirK protein H1Y02_RS09090 ENOG4108R1E Serine threonine protein phosphatase 1 H1Y02_RS09095 ENOG4105UVW uncharacterized protein yebW H1Y02_RS09100 ENOG4105WT8 Protein of unknown function (DUF1480) H1Y02_RS09110 ENOG4105DY2 Paraquat-inducible protein b H1Y02_RS09115 ENOG4105H2K paraquat-inducible protein a H1Y02_RS09120 ENOG4108ZGC gaf domain protein H1Y02_RS09125 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) H1Y02_RS09130 ENOG4105CN1 protease H1Y02_RS09135 ENOG4105D0M Protease HtpX homolog H1Y02_RS09140 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Y02_RS09145 ENOG4105J4Q Transcriptional regulator H1Y02_RS09150 ENOG4105TIK H1Y02_RS09160 ENOG4105Q3Y exported protein H1Y02_RS09175 ENOG4105CJN penicillin-binding protein H1Y02_RS09180 ENOG4105DHI Methyltransferase H1Y02_RS09185 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) H1Y02_RS09195 ENOG4105F3R pts system mannose fructose sorbose family iid H1Y02_RS09200 ENOG4105ETZ PTS System H1Y02_RS09205 ENOG4105DAS pts system H1Y02_RS09210 ENOG4105EE5 Membrane protein terC H1Y02_RS09215 ENOG4107XTP (EAL) domain protein H1Y02_RS09220 ENOG4105EJQ L-serine dehydratase H1Y02_RS09225 ENOG4105P8F nudix hydrolase H1Y02_RS09235 ENOG4105X5C UPF0181 protein H1Y02_RS09240 ENOG4105M4H endoribonuclease L-psp H1Y02_RS09245 ENOG4105DVT helicase H1Y02_RS09250 ENOG41072GX Peptidase M22 Glycoprotease H1Y02_RS09255 ENOG4105Y4Z Outer Membrane Lipoprotein H1Y02_RS09260 ENOG4105CEY Amp-dependent synthetase and ligase H1Y02_RS09265 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) H1Y02_RS09275 ENOG4107QMS site-determining protein H1Y02_RS09280 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) H1Y02_RS09290 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H1Y02_RS09295 ENOG4108ZZ3 UPF0260 protein H1Y02_RS09305 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) H1Y02_RS09310 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H1Y02_RS09320 ENOG4105ED1 spovr family H1Y02_RS09345 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H1Y02_RS09350 ENOG4106JQ5 Transglycosylase SLT domain H1Y02_RS09365 ENOG4105E0K tonB-dependent siderophore receptor H1Y02_RS09375 ENOG4105CT4 transporter H1Y02_RS09410 ENOG4107UH8 sugar kinase H1Y02_RS09425 ENOG4105XN3 extracellular solute-binding protein family 1 H1Y02_RS09430 ENOG4105DKQ ROK family H1Y02_RS09455 ENOG4105E90 ABC transporter H1Y02_RS09460 ENOG4105E90 ABC transporter H1Y02_RS09465 ENOG4108IJ8 ABC transporter H1Y02_RS09475 ENOG410811B TRANSCRIPTIONal H1Y02_RS09485 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS09495 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS09505 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) H1Y02_RS09515 ENOG4105C6N Formate acetyltransferase H1Y02_RS09530 ENOG4105C32 Amino acid ABC transporter (Permease) H1Y02_RS09535 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H1Y02_RS09540 ENOG4105C0Z ABC transporter H1Y02_RS09545 ENOG4108IV0 ABC, transporter H1Y02_RS09550 ENOG4107YNJ LysR family Transcriptional regulator H1Y02_RS09570 ENOG4105CSH Transporter H1Y02_RS09580 ENOG4105F04 LysR family Transcriptional regulator H1Y02_RS09590 ENOG4105D3G Pseudouridine synthase H1Y02_RS09595 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme H1Y02_RS09620 ENOG4105C3G gtp-binding protein H1Y02_RS09625 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H1Y02_RS09630 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria H1Y02_RS09640 ENOG4105CHH sulfate transporter H1Y02_RS09645 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H1Y02_RS09660 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H1Y02_RS09665 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H1Y02_RS09670 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H1Y02_RS09675 ENOG4108YY7 Invasion gene expression up-regulator SirB H1Y02_RS09680 ENOG41063JG Transcriptional regulator H1Y02_RS09685 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H1Y02_RS09690 ENOG4105EWV Sodium calcium exchanger membrane region H1Y02_RS09695 ENOG4105WS7 Cation transport regulator H1Y02_RS09700 ENOG4108NH8 Cation transport protein H1Y02_RS09710 ENOG41090EX DsrE family H1Y02_RS09730 ENOG4105D7T ABC transporter H1Y02_RS09735 ENOG4107QZF nitrite reductase NADPH large subunit H1Y02_RS09745 ENOG4105ID0 Putative invasin H1Y02_RS09750 ENOG4105WH1 Two component transcriptional regulator luxr family H1Y02_RS09755 ENOG4105BZU Histidine kinase H1Y02_RS09760 ENOG4105DQQ Major facilitator superfamily MFS_1 H1Y02_RS09765 ENOG4105CRU nitrate reductase, alpha subunit H1Y02_RS09770 ENOG4108IUE nitrate reductase beta subunit H1Y02_RS09775 ENOG4105R3A Nitrate reductase H1Y02_RS09780 ENOG41076YT nitrate reductase, gamma subunit H1Y02_RS09810 ENOG4105CIY formyltetrahydrofolate deformylase H1Y02_RS09820 ENOG4105D78 K07001 NTE family protein H1Y02_RS09825 ENOG4105I93 response regulator H1Y02_RS09830 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H1Y02_RS09840 ENOG4107104 thymidine kinase H1Y02_RS09845 ENOG4105C0A alcohol dehydrogenase H1Y02_RS09855 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H1Y02_RS09860 ENOG4108J59 Extracellular solute-binding protein, family 5 H1Y02_RS09865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Y02_RS09870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS09875 ENOG4105C3U ABC transporter H1Y02_RS09880 ENOG4108JQ7 (ABC) transporter H1Y02_RS09885 ENOG4105EYW Ion transport protein H1Y02_RS09890 ENOG4108W5H UPF0263 protein H1Y02_RS09905 ENOG4108YYC ycei family H1Y02_RS09910 ENOG4105K9H YciI-like protein H1Y02_RS09915 ENOG410822N TonB family H1Y02_RS09925 ENOG4105P10 Uncharacterized protein ydiZ H1Y02_RS09930 ENOG4105DE4 1-phosphofructokinase H1Y02_RS09935 ENOG4108NE3 Salt-induced outer membrane protein H1Y02_RS09950 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H1Y02_RS09955 ENOG41082NX 50s ribosomal protein l35 H1Y02_RS09970 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H1Y02_RS09975 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H1Y02_RS09980 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H1Y02_RS09990 ENOG4105MWK D-amino acid dehydrogenase, small subunit H1Y02_RS09995 ENOG4105RQF LysR family Transcriptional regulator H1Y02_RS10005 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) H1Y02_RS10010 ENOG4105D01 (LipO)protein H1Y02_RS10015 ENOG4108V06 Glutathione peroxidase H1Y02_RS10025 ENOG4108QBX (LipO)protein H1Y02_RS10040 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H1Y02_RS10055 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H1Y02_RS10065 ENOG4105IPI Membrane H1Y02_RS10070 ENOG4105CQB FAD linked oxidase domain protein H1Y02_RS10075 ENOG4105KA0 thioesterase Superfamily protein H1Y02_RS10080 ENOG4105F2I Transposase H1Y02_RS10085 ENOG4105Y3U Transglycosylase-associated protein H1Y02_RS10100 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) H1Y02_RS10110 ENOG4105E0A ABC, transporter H1Y02_RS10115 ENOG4105DQ5 transport system permease protein H1Y02_RS10125 ENOG4106KR7 LysR family Transcriptional regulator H1Y02_RS10150 ENOG4105DMF Dehydrogenase H1Y02_RS10165 ENOG4108Z4V iron-sulfur cluster assembly H1Y02_RS10170 ENOG4105DIW FeS assembly protein SUFB H1Y02_RS10175 ENOG4105C3K feS assembly ATPase SufC H1Y02_RS10180 ENOG4105JRK feS assembly protein SufD H1Y02_RS10185 ENOG4105C9B Cysteine desulfurase H1Y02_RS10195 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H1Y02_RS10205 ENOG4105CA9 Pyruvate kinase H1Y02_RS10215 ENOG4105RFR Protein of unknown function (DUF2767) H1Y02_RS10230 ENOG4105DJB Major Facilitator Superfamily H1Y02_RS10240 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein H1Y02_RS10245 ENOG4108W0P ABC transporter H1Y02_RS10250 ENOG4105EHG Permease protein H1Y02_RS10255 ENOG4105S10 periplasmic binding protein H1Y02_RS10260 ENOG4108K2P TRANSCRIPTIONal H1Y02_RS10275 ENOG4107UB2 Alpha beta hydrolase fold H1Y02_RS10280 ENOG4105IKQ hydratase H1Y02_RS10290 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) H1Y02_RS10295 ENOG4108SC4 )-transporter H1Y02_RS10310 ENOG4108T2C cysteine dioxygenase type I H1Y02_RS10315 ENOG4106KR7 LysR family Transcriptional regulator H1Y02_RS10320 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) H1Y02_RS10325 ENOG4107T8P acyl-Coa dehydrogenase H1Y02_RS10340 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H1Y02_RS10345 ENOG4108IY8 ABC, transporter H1Y02_RS10355 ENOG4105E0A ABC, transporter H1Y02_RS10360 ENOG4105DQ5 transport system permease protein H1Y02_RS10370 ENOG4108HUF Transporter H1Y02_RS10380 ENOG4106PMH Extracellular solute-binding protein family 3 H1Y02_RS10385 ENOG4105E5Q amino acid AbC transporter H1Y02_RS10390 ENOG4105CDA abc transporter atp-binding protein H1Y02_RS10395 ENOG4105KZM cytoplasmic protein H1Y02_RS10420 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H1Y02_RS10425 ENOG4105DG4 malate L-lactate dehydrogenase H1Y02_RS10430 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC H1Y02_RS10435 ENOG4107Z33 ABC transporter, permease H1Y02_RS10465 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS10470 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) H1Y02_RS10475 ENOG41060IM Heme exporter protein H1Y02_RS10485 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) H1Y02_RS10490 ENOG4105DA4 cytochrome c-type biogenesis protein H1Y02_RS10500 ENOG4105KWW Biogenesis protein H1Y02_RS10520 ENOG410822N TonB family H1Y02_RS10535 ENOG41062D9 Histidine kinase H1Y02_RS10540 ENOG4105E3W Two component transcriptional regulator (Winged helix family H1Y02_RS10565 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS10575 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS10590 ENOG4105CHR reductase H1Y02_RS10595 ENOG4105C7K acetolactate synthase H1Y02_RS10610 ENOG4105DTD Dehydrogenase H1Y02_RS10615 ENOG4105CY2 Citrate transporter H1Y02_RS10620 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) H1Y02_RS10625 ENOG4105CHU acetyl-coa acetyltransferase H1Y02_RS10630 ENOG4107QNJ CoA-transferase subunit B H1Y02_RS10640 ENOG4106NZI LysR family Transcriptional regulator H1Y02_RS10670 ENOG4105DXI Major Facilitator superfamily H1Y02_RS10705 ENOG4105CQB FAD linked oxidase domain protein H1Y02_RS10710 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component H1Y02_RS10730 ENOG4105KME endoribonuclease L-psp H1Y02_RS10735 ENOG4107TTD cytosine deaminase H1Y02_RS10745 ENOG4105EMY transcriptional regulator H1Y02_RS10765 ENOG4105CC0 LysR family Transcriptional regulator H1Y02_RS10805 ENOG4105ENX hydrolase H1Y02_RS10810 ENOG4105EQ2 LysR family Transcriptional regulator H1Y02_RS10830 ENOG4108JQ7 (ABC) transporter H1Y02_RS10835 ENOG4105C3U ABC transporter H1Y02_RS10860 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase H1Y02_RS10865 ENOG4105E98 transcriptional regulator DeoR family H1Y02_RS10875 ENOG4107B2H carbonic anhydrase H1Y02_RS10910 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H1Y02_RS10930 ENOG4107FW0 short-chain dehydrogenase reductase H1Y02_RS10950 ENOG4108URH decarboxylase H1Y02_RS10965 ENOG4107QI1 Mate efflux family protein H1Y02_RS10970 ENOG4108R6K riboflavin synthase, subunit alpha H1Y02_RS10975 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H1Y02_RS10980 ENOG4105CZQ inner membrane transport protein YdhC H1Y02_RS10985 ENOG4105F52 Transcriptional regulator H1Y02_RS11000 ENOG4105F27 Major Facilitator H1Y02_RS11005 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H1Y02_RS11015 ENOG4105K4H Nlp p60 protein H1Y02_RS11020 ENOG4105M2J Glutaredoxin H1Y02_RS11025 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) H1Y02_RS11030 ENOG4108UYE Lactoylglutathione lyase H1Y02_RS11035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H1Y02_RS11040 ENOG4108WUH Transcriptional regulator, TetR family H1Y02_RS11045 ENOG4105XZD Fe-S protein H1Y02_RS11050 ENOG4107RGM aldo keto reductase H1Y02_RS11055 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H1Y02_RS11060 ENOG4105DSW Fusaric acid resistance protein H1Y02_RS11065 ENOG4105Y49 secretion protein, HlyD family H1Y02_RS11080 ENOG4105BZU Histidine kinase H1Y02_RS11085 ENOG4108XTF Outer Membrane Lipoprotein H1Y02_RS11095 ENOG410642K Lysozyme inhibitor H1Y02_RS11100 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) H1Y02_RS11110 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H1Y02_RS11115 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) H1Y02_RS11120 ENOG4108K3A Glutathione S-transferase H1Y02_RS11130 ENOG4105CSM endonuclease III H1Y02_RS11140 ENOG4108UQQ Electron transport complex H1Y02_RS11165 ENOG4105M9B inner membrane protein ydgK H1Y02_RS11175 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS11185 ENOG4105D9R oxidoreductase H1Y02_RS11215 ENOG4105CPW cytochrome b561 H1Y02_RS11235 ENOG4105DDW LysR family Transcriptional regulator H1Y02_RS11240 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha H1Y02_RS11245 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta H1Y02_RS11250 ENOG4105E32 cytoplasmic protein H1Y02_RS11255 ENOG4105EBR Carboxylesterase H1Y02_RS11265 ENOG4108Z9I -acetyltransferase H1Y02_RS11270 ENOG4107WE3 acetyltransferase YdcK H1Y02_RS11275 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein H1Y02_RS11280 ENOG41088CC tellurite resistance protein tehB H1Y02_RS11285 ENOG4108KKZ (LipO)protein H1Y02_RS11290 ENOG4105DWP Membrane H1Y02_RS11295 ENOG4105UEI Transcriptional Regulator AraC Family H1Y02_RS11300 ENOG4105DKK Benzoate H1Y02_RS11305 ENOG4108JCI Transcriptional regulator H1Y02_RS11315 ENOG4105CFP Peptidase U32 H1Y02_RS11335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H1Y02_RS11340 ENOG4105C4M (Ubiquinol oxidase) subunit I H1Y02_RS11345 ENOG4105F2I Transposase H1Y02_RS11360 ENOG410654E Membrane H1Y02_RS11365 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 H1Y02_RS11375 ENOG4105DEF Extracellular solute-binding protein, family 5 H1Y02_RS11380 ENOG4105R71 cytoplasmic protein H1Y02_RS11385 ENOG4108T9Y Inner membrane protein ydcZ H1Y02_RS11390 ENOG4108Z7F N-acetyltransferase H1Y02_RS11400 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H1Y02_RS11405 ENOG4105DU0 nucleoside hydrolase H1Y02_RS11410 ENOG41065TG regulatoR H1Y02_RS11415 ENOG4105CHB tonB-dependent Receptor H1Y02_RS11420 ENOG4108NS2 receptor H1Y02_RS11430 ENOG4105C85 amino acid H1Y02_RS11435 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H1Y02_RS11440 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H1Y02_RS11445 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H1Y02_RS11450 ENOG4105DEN Luciferase family H1Y02_RS11465 ENOG4105EAB amino acid AbC transporter H1Y02_RS11475 ENOG4105DRP amino acid AbC transporter H1Y02_RS11480 ENOG4105CDA abc transporter atp-binding protein H1Y02_RS11490 ENOG4108N27 Glutathione S-transferase H1Y02_RS11500 ENOG4105F2I Transposase H1Y02_RS11510 ENOG4105CT4 transporter H1Y02_RS11525 ENOG4108MEJ flavin reductase domain protein H1Y02_RS11530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS11535 ENOG4105C4Y ABC transporter H1Y02_RS11540 ENOG4107RCV ABC transporter, permease H1Y02_RS11545 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase H1Y02_RS11560 ENOG4107HP6 Transcriptional regulator H1Y02_RS11565 ENOG4105DTQ mandelate racemase muconate lactonizing H1Y02_RS11570 ENOG4105NN7 muconolactone delta-isomerase H1Y02_RS11575 ENOG410626B catechol 1,2-dioxygenase H1Y02_RS11610 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H1Y02_RS11615 ENOG4108MG3 formate dehydrogenase H1Y02_RS11630 ENOG4105CSR polyphosphate kinase 2 H1Y02_RS11640 ENOG4105F27 Major Facilitator H1Y02_RS11660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS11665 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Y02_RS11675 ENOG4105DQ4 alcohol dehydrogenase H1Y02_RS11690 ENOG4105C5H ABC transporter H1Y02_RS11725 ENOG4105EQ2 LysR family Transcriptional regulator H1Y02_RS11730 ENOG4105N0E Protein of unknown function (DUF2543) H1Y02_RS11735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H1Y02_RS11750 ENOG4108N8X transition metal ion binding H1Y02_RS11760 ENOG4105CG3 alpha amylase, catalytic region H1Y02_RS11780 ENOG4108YDI single-species biofilm formation on inanimate substrate H1Y02_RS11790 ENOG4108Z9K Osmotically inducible protein H1Y02_RS11815 ENOG41076HS cation diffusion facilitator family transporter H1Y02_RS11820 ENOG4105FFC UPF0187 protein H1Y02_RS11825 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit H1Y02_RS11830 ENOG4105C5Q Transcriptional regulator H1Y02_RS11835 ENOG4108KUU Inner membrane metabolite transport protein ydjE H1Y02_RS11840 ENOG4105KT7 mgtC SapB transporter H1Y02_RS11845 ENOG4105D6Z AFG1 family ATPase H1Y02_RS11850 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) H1Y02_RS11865 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H1Y02_RS11870 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF H1Y02_RS11885 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) H1Y02_RS11890 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) H1Y02_RS11900 ENOG4108IGT Dipeptidase H1Y02_RS11905 ENOG4108J2P Alpha beta hydrolase fold H1Y02_RS11915 ENOG4105E0F Histidine kinase H1Y02_RS11925 ENOG4105W8I Transcriptional regulator H1Y02_RS11930 ENOG4105DY8 decarboxylase H1Y02_RS11935 ENOG4108JPW Aminotransferase H1Y02_RS11940 ENOG4107Z6I Thiamine biosynthesis protein H1Y02_RS11945 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component H1Y02_RS11950 ENOG4108YI8 ABC transporter H1Y02_RS11955 ENOG4105ETU transcriptional activator (TenA H1Y02_RS11975 ENOG4105CIB oxidoreductase Domain protein H1Y02_RS11985 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS11990 ENOG4105BZU Histidine kinase H1Y02_RS12000 ENOG4107QUY Guanine deaminase H1Y02_RS12005 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease H1Y02_RS12040 ENOG4105CVJ phosphoglycerate mutase H1Y02_RS12050 ENOG4105F2I Transposase H1Y02_RS12060 ENOG4105CMU LysR family (Transcriptional regulator H1Y02_RS12075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H1Y02_RS12100 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H1Y02_RS12125 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H1Y02_RS12145 ENOG4105E5Q amino acid AbC transporter H1Y02_RS12155 ENOG4105C5R Aminotransferase H1Y02_RS12165 ENOG4105EA8 2-Nitropropane dioxygenase H1Y02_RS12170 ENOG4105CBN LysR family transcriptional regulator H1Y02_RS12180 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H1Y02_RS12185 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain H1Y02_RS12190 ENOG4105CSH Transporter H1Y02_RS12220 ENOG4105FCD Major Facilitator H1Y02_RS12235 ENOG4105D7T ABC transporter H1Y02_RS12245 ENOG4105EIG urea carboxylase-associated protein 1 H1Y02_RS12250 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H1Y02_RS12270 ENOG410829K Lysine exporter protein (Lyse ygga) H1Y02_RS12280 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS12290 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS12305 ENOG4105CW0 outer membrane usher protein H1Y02_RS12340 ENOG4105CBN LysR family transcriptional regulator H1Y02_RS12350 ENOG4107PP3 Acetylornithine deacetylase H1Y02_RS12365 ENOG4105CNN ABC, transporter H1Y02_RS12370 ENOG4105C2J ABC transporter H1Y02_RS12375 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS12425 ENOG4105BZU Histidine kinase H1Y02_RS12460 ENOG4107YCY Transcriptional regulator H1Y02_RS12465 ENOG4105CI1 PTS System H1Y02_RS12470 ENOG4105F8D glycoside hydrolase family 4 H1Y02_RS12475 ENOG4105C54 Major Facilitator superfamily H1Y02_RS12480 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein H1Y02_RS12495 ENOG4105NIV Esterase H1Y02_RS12500 ENOG4105BZU Histidine kinase H1Y02_RS12515 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H1Y02_RS12520 ENOG4105FQP Beta-lactamase H1Y02_RS12540 ENOG4105F32 YngK protein H1Y02_RS12545 ENOG4105CAF HipA N-terminal domain protein H1Y02_RS12550 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein H1Y02_RS12555 ENOG4105VT2 5-hydroxyisourate hydrolase H1Y02_RS12560 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) H1Y02_RS12565 ENOG4105C2W permease H1Y02_RS12570 ENOG41061H0 Monooxygenase H1Y02_RS12575 ENOG4108KSA LysR family transcriptional regulator H1Y02_RS12595 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions H1Y02_RS12610 ENOG4105VYA Uncharacterized conserved protein (DUF2132) H1Y02_RS12620 ENOG4105D01 (LipO)protein H1Y02_RS12630 ENOG4108UMI ABC transporter, permease H1Y02_RS12635 ENOG4105EA8 2-Nitropropane dioxygenase H1Y02_RS12640 ENOG4105EGI Transcriptional regulator H1Y02_RS12650 ENOG4105F9N Major Facilitator Superfamily H1Y02_RS12675 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) H1Y02_RS12680 ENOG4107QZW Altronate oxidoreductase H1Y02_RS12690 ENOG4105BZU Histidine kinase H1Y02_RS12695 ENOG4105M0C cytoplasmic protein H1Y02_RS12700 ENOG4105CSV Glutaminase H1Y02_RS12705 ENOG4105C26 Dehydrogenase H1Y02_RS12710 ENOG4105EGI Transcriptional regulator H1Y02_RS12720 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H1Y02_RS12730 ENOG4105JAB phenazine biosynthesis protein, phzf family H1Y02_RS12735 ENOG4105F27 Major Facilitator H1Y02_RS12745 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes H1Y02_RS12750 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF H1Y02_RS12755 ENOG4106DNR multiple antibiotic resistance protein H1Y02_RS12760 ENOG4108594 Permease of the drug metabolite transporter H1Y02_RS12765 ENOG4105E5W Transporter H1Y02_RS12775 ENOG4108IV0 ABC, transporter H1Y02_RS12785 ENOG4105CNN ABC, transporter H1Y02_RS12790 ENOG4105C32 Amino acid ABC transporter (Permease) H1Y02_RS12825 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS12835 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) H1Y02_RS12855 ENOG4105MVE transcriptional regulator H1Y02_RS12865 ENOG4105G63 Type III effector Hrp-dependent H1Y02_RS12870 ENOG4105FB2 class II Aldolase H1Y02_RS12875 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H1Y02_RS12880 ENOG4105C6Z Gluconate H1Y02_RS12895 ENOG4105BZU Histidine kinase H1Y02_RS12900 ENOG4108WTK competence damage-inducible protein H1Y02_RS12905 ENOG4108ZNX Heat shock protein H1Y02_RS12915 ENOG4108RAV Conserved protein H1Y02_RS12920 ENOG41068WN H1Y02_RS12935 ENOG4105DGW oligopeptidase A H1Y02_RS12940 ENOG4105EMU Dehydrogenase H1Y02_RS12945 ENOG4107XBN GntR Family Transcriptional Regulator H1Y02_RS12950 ENOG4108U51 Universal stress protein H1Y02_RS12955 ENOG4105DEI Mannitol dehydrogenase H1Y02_RS12960 ENOG4108I5G Major Facilitator superfamily H1Y02_RS12965 ENOG4105KK4 UPF0060 membrane protein H1Y02_RS12975 ENOG4108MK9 spermidine N(1)-acetyltransferase H1Y02_RS12985 ENOG4105KBG Protein of unknown function (DUF1161) H1Y02_RS12990 ENOG4107QY8 reductase H1Y02_RS12995 ENOG4105QAX Iron-sulfur H1Y02_RS13000 ENOG4107KGK dmso reductase anchor subunit H1Y02_RS13005 ENOG4108NEM leader-binding protein dmsD H1Y02_RS13010 ENOG4105CMQ Chloride channel H1Y02_RS13015 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H1Y02_RS13035 ENOG4106NZI LysR family Transcriptional regulator H1Y02_RS13040 ENOG4105D94 Major Facilitator Superfamily H1Y02_RS13045 ENOG4105CTD carboxy-peptidase H1Y02_RS13050 ENOG4105F2I Transposase H1Y02_RS13060 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap H1Y02_RS13065 ENOG4105BZU Histidine kinase H1Y02_RS13070 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) H1Y02_RS13075 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) H1Y02_RS13080 ENOG4105DSF transport protein H1Y02_RS13110 ENOG4107TT2 Auxin Efflux Carrier H1Y02_RS13120 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H1Y02_RS13125 ENOG4108K70 Transcriptional regulator H1Y02_RS13130 ENOG4105DWT malate dehydrogenase (quinone) H1Y02_RS13135 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H1Y02_RS13145 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H1Y02_RS13150 ENOG4108MRH transcriptional regulatory protein H1Y02_RS13160 ENOG4107EFR Flavocytochrome c H1Y02_RS13170 ENOG4107GFK fumarate H1Y02_RS13180 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase H1Y02_RS13185 ENOG4105F2Z 3-oxoadipate enol-lactonase H1Y02_RS13190 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase H1Y02_RS13195 ENOG4105CHU acetyl-coa acetyltransferase H1Y02_RS13200 ENOG4107QNJ CoA-transferase subunit B H1Y02_RS13210 ENOG4107HP6 Transcriptional regulator H1Y02_RS13215 ENOG4108DG9 Smr protein MutS2 H1Y02_RS13220 ENOG4106KR7 LysR family Transcriptional regulator H1Y02_RS13230 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B H1Y02_RS13235 ENOG4105CFC Transporter H1Y02_RS13245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H1Y02_RS13250 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H1Y02_RS13255 ENOG4105Q9Y Universal stress protein H1Y02_RS13260 ENOG410671Z uncharacterized protein ydiH H1Y02_RS13265 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H1Y02_RS13270 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H1Y02_RS13280 ENOG4105C5D exported protein H1Y02_RS13285 ENOG4105D5Q Arginine ornithine antiporter H1Y02_RS13290 ENOG410642E Short chain dehydrogenase H1Y02_RS13295 ENOG4105RA2 Membrane H1Y02_RS13300 ENOG4107EXC regulatoR H1Y02_RS13310 ENOG4105JJR Histidine kinase H1Y02_RS13320 ENOG4105C9Q fumarate hydratase class II H1Y02_RS13325 ENOG4107GFK fumarate H1Y02_RS13330 ENOG4105EIP mannose-6-phosphate isomerase H1Y02_RS13335 ENOG4106J39 exported protein H1Y02_RS13340 ENOG4107P2S Transcriptional regulator H1Y02_RS13345 ENOG4105CI1 PTS System H1Y02_RS13350 ENOG4105C87 Aminotransferase class I and II H1Y02_RS13360 ENOG41061EV selenium-binding protein YdfZ H1Y02_RS13375 ENOG41066VF YeeE YedE family protein H1Y02_RS13390 ENOG4105VPI YqaE family transport protein H1Y02_RS13395 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H1Y02_RS13400 ENOG4105C26 Dehydrogenase H1Y02_RS13410 ENOG4107DB1 DUF218 domain H1Y02_RS13415 ENOG4105CSH Transporter H1Y02_RS13425 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) H1Y02_RS13430 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) H1Y02_RS13435 ENOG4105C26 Dehydrogenase H1Y02_RS13440 ENOG4105F4X arginine H1Y02_RS13445 ENOG4105C8Y Acetylornithine aminotransferase H1Y02_RS13455 ENOG4105D82 Glutamate dehydrogenase H1Y02_RS13470 ENOG4105CHU acetyl-coa acetyltransferase H1Y02_RS13480 ENOG4105CPC Aldo Keto reductase H1Y02_RS13485 ENOG4105F27 Major Facilitator H1Y02_RS13490 ENOG4108FN7 Aldo keto reductase H1Y02_RS13495 ENOG410642W LysR family Transcriptional regulator H1Y02_RS13515 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H1Y02_RS13530 ENOG4105CQ7 ATP-dependent helicase H1Y02_RS13535 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H1Y02_RS13545 ENOG4108Z0R Transferase H1Y02_RS13550 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein H1Y02_RS13555 ENOG4105DZS Phenylacetate-CoA ligase H1Y02_RS13560 ENOG4105CHU acetyl-coa acetyltransferase H1Y02_RS13565 ENOG4108ZJI phenylacetic acid degradation protein H1Y02_RS13570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H1Y02_RS13575 ENOG4108UKI Enoyl-CoA hydratase H1Y02_RS13580 ENOG4105E39 Enoyl-CoA hydratase H1Y02_RS13585 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H1Y02_RS13590 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit H1Y02_RS13595 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit H1Y02_RS13600 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit H1Y02_RS13605 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit H1Y02_RS13610 ENOG4105DXM phenylacetic acid degradation protein H1Y02_RS13620 ENOG4105F11 amine oxidase H1Y02_RS13635 ENOG4105CWC Acetylornithine deacetylase H1Y02_RS13645 ENOG4105KME endoribonuclease L-psp H1Y02_RS13650 ENOG4105H3G oxidoreductase H1Y02_RS13655 ENOG4108KB2 LysR family Transcriptional regulator H1Y02_RS13670 ENOG4105EAB amino acid AbC transporter H1Y02_RS13685 ENOG4105C26 Dehydrogenase H1Y02_RS13690 ENOG4108WFR AraC Family Transcriptional Regulator H1Y02_RS13695 ENOG4105WXT Conserved Protein H1Y02_RS13700 ENOG410689M (LipO)protein H1Y02_RS13705 ENOG4107H52 Dicarboxylate transport H1Y02_RS13710 ENOG4108KF1 Membrane H1Y02_RS13715 ENOG4105C5I Dehydrogenase H1Y02_RS13720 ENOG41090X5 Heat shock protein hslJ H1Y02_RS13725 ENOG4105IKK cytoplasmic protein H1Y02_RS13730 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) H1Y02_RS13735 ENOG4105FCK Membrane H1Y02_RS13750 ENOG4108RW8 Universal stress protein F H1Y02_RS13760 ENOG4105C1J atp-dependent rna helicase H1Y02_RS13770 ENOG4105E98 transcriptional regulator DeoR family H1Y02_RS13775 ENOG4105D9R oxidoreductase H1Y02_RS13790 ENOG4105C85 amino acid H1Y02_RS13795 ENOG4105F7P transcriptional regulator AsnC family H1Y02_RS13805 ENOG4105CGF Aromatic amino acid aminotransferase H1Y02_RS13810 ENOG4108UMI ABC transporter, permease H1Y02_RS13820 ENOG4105D01 (LipO)protein H1Y02_RS13850 ENOG4105HEI LysR family (Transcriptional regulator H1Y02_RS13865 ENOG4105CF7 AraC family transcriptional regulator H1Y02_RS13875 ENOG4105F6U Short-chain dehydrogenase reductase Sdr H1Y02_RS13880 ENOG4106FE3 DNA repair H1Y02_RS13885 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS13895 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS13920 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS13930 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS13950 ENOG4105BZU Histidine kinase H1Y02_RS13965 ENOG4107RTG Major Facilitator superfamily H1Y02_RS13970 ENOG4105ENX hydrolase H1Y02_RS13975 ENOG4105EQ2 LysR family Transcriptional regulator H1Y02_RS13995 ENOG4105KXI murein peptide amidase A H1Y02_RS14000 ENOG4107S8C mandelate racemase muconate lactonizing H1Y02_RS14005 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H1Y02_RS14010 ENOG4108KK1 membrane protein AbrB duplication H1Y02_RS14015 ENOG4108JU8 Transcriptional regulator H1Y02_RS14025 ENOG4105CM6 amino acid regulated cytosolic protein H1Y02_RS14030 ENOG4105NNG Peripheral inner membrane phage-shock protein H1Y02_RS14035 ENOG4105FM1 phage shock protein C H1Y02_RS14040 ENOG4105YYT phage shock protein B H1Y02_RS14045 ENOG41087YS Phage shock protein A H1Y02_RS14050 ENOG4105E51 psp operon transcriptional activator H1Y02_RS14060 ENOG4105CH2 amidohydrolase H1Y02_RS14080 ENOG4108J59 Extracellular solute-binding protein, family 5 H1Y02_RS14085 ENOG4108EKA peptide transport system, permease H1Y02_RS14090 ENOG4108EU3 peptide transport system, permease H1Y02_RS14095 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein H1Y02_RS14100 ENOG4108JQ2 peptide transport system atp-binding protein H1Y02_RS14105 ENOG4105C84 Histidine ammonia-lyase H1Y02_RS14110 ENOG4108JEH abc transporter atp-binding protein H1Y02_RS14135 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H1Y02_RS14140 ENOG4105Q4T oxidoreductase H1Y02_RS14145 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) H1Y02_RS14155 ENOG4105N2W Transcriptional regulator H1Y02_RS14160 ENOG41061RM osmotically inducible lipoprotein H1Y02_RS14165 ENOG4108ZJT translation initiation factor, Sui1 H1Y02_RS14175 ENOG4105CFV Tetratricopeptide repeat protein H1Y02_RS14180 ENOG4105Q4A inner membrane protein yciS H1Y02_RS14185 ENOG4105EYK Phosphatidylglycerophosphatase B H1Y02_RS14195 ENOG4107QM5 aconitate hydratase H1Y02_RS14200 ENOG4105F2I Transposase H1Y02_RS14205 ENOG4107R11 Transcriptional regulator H1Y02_RS14210 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H1Y02_RS14215 ENOG4105RKX Protein of unknown function (DUF2498) H1Y02_RS14220 ENOG4105ERU peptidase H1Y02_RS14225 ENOG4105UBK short-chain dehydrogenase reductase H1Y02_RS14230 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase H1Y02_RS14235 ENOG4105FE9 pseudouridine synthase H1Y02_RS14240 ENOG4105ETT transcriptional Regulator, LysR family H1Y02_RS14250 ENOG4107RTD sua5 ycio yrdc ywlc family protein H1Y02_RS14255 ENOG4105DB7 PHP domain protein H1Y02_RS14260 ENOG4105CRQ synthase (Component I) H1Y02_RS14265 ENOG4108EFP Anthranilate synthase component II H1Y02_RS14270 ENOG4105DK0 Indole-3-glycerol phosphate synthase H1Y02_RS14275 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H1Y02_RS14280 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H1Y02_RS14305 ENOG4108IU3 tonb-dependent siderophore receptor H1Y02_RS14310 ENOG4107E2E PKHD-type hydroxylase H1Y02_RS14315 ENOG4105EIF outer membrane protein W H1Y02_RS14320 ENOG4105PI0 Ferredoxin H1Y02_RS14325 ENOG4108S3I UPF0259 membrane protein H1Y02_RS14335 ENOG4107RNH Outer membrane receptor FepA H1Y02_RS14340 ENOG4105NAU thioesterase Superfamily protein H1Y02_RS14345 ENOG4107PN8 YfeABCD locus regulator H1Y02_RS14350 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H1Y02_RS14355 ENOG4105CHR reductase H1Y02_RS14360 ENOG4107K5X Membrane-bound metal-dependent hydrolase H1Y02_RS14365 ENOG4108ETY sodium dicarboxylate symporter H1Y02_RS14370 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) H1Y02_RS14375 ENOG4105CH6 catalase H1Y02_RS14385 ENOG4105F8D glycoside hydrolase family 4 H1Y02_RS14390 ENOG4105EZV Transcriptional regulator H1Y02_RS14395 ENOG4105VCP PTS System H1Y02_RS14400 ENOG4105CK1 PTS System H1Y02_RS14415 ENOG4105VZJ PTS System H1Y02_RS14420 ENOG4105KKI DNA-binding transcriptional activator OsmE H1Y02_RS14430 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) H1Y02_RS14435 ENOG4108SPG Periplasmic Protein H1Y02_RS14445 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) H1Y02_RS14450 ENOG4105C26 Dehydrogenase H1Y02_RS14455 ENOG4105F4X arginine H1Y02_RS14465 ENOG4105CGK Exodeoxyribonuclease III H1Y02_RS14470 ENOG4108RSN SNARE associated Golgi H1Y02_RS14475 ENOG4108N5C SNARE associated Golgi protein-related protein H1Y02_RS14480 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H1Y02_RS14485 ENOG4105VNH ABC transporter solute-binding protein H1Y02_RS14490 ENOG4105CXZ ABC transporter, permease H1Y02_RS14495 ENOG4108VGW abc transporter atp-binding protein H1Y02_RS14500 ENOG4107RM6 sulfurtransferase H1Y02_RS14505 ENOG4108T9J Cdp-alcohol phosphatidyltransferase H1Y02_RS14510 ENOG4105M6F mutator MutT protein H1Y02_RS14515 ENOG4105D82 Glutamate dehydrogenase H1Y02_RS14525 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H1Y02_RS14530 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) H1Y02_RS14535 ENOG4105SBG acid phosphatase H1Y02_RS14540 ENOG41069NU Nitroreductase H1Y02_RS14545 ENOG4105D07 Signal peptide peptidase, SppA H1Y02_RS14550 ENOG4105HDK L-asparaginase H1Y02_RS14555 ENOG4108RWI nicotinamidase H1Y02_RS14565 ENOG4105N1F Hnh endonuclease H1Y02_RS14570 ENOG4105VUT cytoplasmic protein H1Y02_RS14575 ENOG4105E0X reductase H1Y02_RS14580 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H1Y02_RS14585 ENOG4105DSB aldose 1-epimerase H1Y02_RS14590 ENOG4105CV8 reductase H1Y02_RS14595 ENOG4105GNX MltA-interacting MipA family protein H1Y02_RS14600 ENOG4105CYN Serine protein kinase H1Y02_RS14610 ENOG4108V06 Glutathione peroxidase H1Y02_RS14635 ENOG4105F27 Major Facilitator H1Y02_RS14645 ENOG4105CDA abc transporter atp-binding protein H1Y02_RS14650 ENOG4105E5Q amino acid AbC transporter H1Y02_RS14655 ENOG4107R0W ABC transporter H1Y02_RS14670 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H1Y02_RS14675 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) H1Y02_RS14680 ENOG4105CR8 Transcriptional regulator H1Y02_RS14685 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H1Y02_RS14695 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr H1Y02_RS14700 ENOG4105CBN LysR family transcriptional regulator H1Y02_RS14710 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Y02_RS14755 ENOG4105F2I Transposase H1Y02_RS14775 ENOG4105KT5 UmuD protein H1Y02_RS14780 ENOG4105EKQ RNA-directed DNA polymerase H1Y02_RS14785 ENOG4105Y50 Virulence Protein H1Y02_RS14790 ENOG4108XNZ glycosyl transferase H1Y02_RS14795 ENOG4108KXH Ybak prolyl-tRNA synthetase associated H1Y02_RS14800 ENOG4108VMM UPF0756 membrane protein H1Y02_RS14805 ENOG4105R1U AraC Family Transcriptional Regulator H1Y02_RS14810 ENOG4105DJ2 Major Facilitator Superfamily H1Y02_RS14815 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H1Y02_RS14820 ENOG4105EWC Purine nucleoside phosphorylase H1Y02_RS14825 ENOG4105K78 MarR family Transcriptional regulator H1Y02_RS14830 ENOG4105UCG Domain of unknown function (DUF333) H1Y02_RS14835 ENOG4105ZTC transcriptional activator, Ogr delta H1Y02_RS14980 ENOG4105ED4 portal protein H1Y02_RS15000 ENOG4105F2I Transposase H1Y02_RS15020 ENOG4105DFE Dna adenine methylase H1Y02_RS15060 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Y02_RS15065 ENOG410620I Diguanylate cyclase H1Y02_RS15070 ENOG4106G4W H1Y02_RS15085 ENOG4105S5I Membrane H1Y02_RS15090 ENOG4108NIW Leucine export protein LeuE H1Y02_RS15095 ENOG4105D1S lipid A biosynthesis H1Y02_RS15105 ENOG4105DHT Metal Dependent Phosphohydrolase H1Y02_RS15110 ENOG4106TD9 Diguanylate cyclase H1Y02_RS15115 ENOG4107RSM transcriptional regulator H1Y02_RS15120 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H1Y02_RS15130 ENOG4105BZU Histidine kinase H1Y02_RS15155 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H1Y02_RS15160 ENOG4105C4M (Ubiquinol oxidase) subunit I H1Y02_RS15165 ENOG4105WEF catalase H1Y02_RS15170 ENOG4108N8X transition metal ion binding H1Y02_RS15175 ENOG4108Z9Z response to DNA damage stimulus H1Y02_RS15185 ENOG4105E2A Dehydrogenase H1Y02_RS15190 ENOG4105XDF Protein of unknown function (DUF1272) H1Y02_RS15225 ENOG4108HMX isocitrate dehydrogenase (NADP) H1Y02_RS15240 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H1Y02_RS15245 ENOG41075W9 High frequency lysogenization protein HflD homolog H1Y02_RS15250 ENOG4107QTF adenylosuccinate lyase H1Y02_RS15265 ENOG4105XJC Two component transcriptional regulator (Winged helix family H1Y02_RS15270 ENOG4105IFJ Histidine kinase H1Y02_RS15275 ENOG4105EZE Cupin 4 family protein H1Y02_RS15280 ENOG4108UK5 Transposase H1Y02_RS15300 ENOG4105D38 putrescine abc transporter H1Y02_RS15305 ENOG4108HM4 ABC transporter H1Y02_RS15315 ENOG4105CEY Amp-dependent synthetase and ligase H1Y02_RS15325 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H1Y02_RS15330 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) H1Y02_RS15335 ENOG4105D60 lipoprotein releasing system transmembrane protein H1Y02_RS15340 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H1Y02_RS15345 ENOG4105D60 lipoprotein releasing system transmembrane protein H1Y02_RS15355 ENOG4108JA2 transcriptioN-repair coupling factor H1Y02_RS15360 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H1Y02_RS15365 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction H1Y02_RS15375 ENOG4108IND Tetr family transcriptional regulator H1Y02_RS15385 ENOG4107MBR 17 kDa surface antigen H1Y02_RS15390 ENOG4105CEP NADH dehydrogenase H1Y02_RS15395 ENOG4105D0Y UPF0227 protein H1Y02_RS15410 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) H1Y02_RS15415 ENOG41090DQ Lipoprotein H1Y02_RS15420 ENOG4105K59 histidine triad (HIT) protein H1Y02_RS15425 ENOG4105CI1 PTS System H1Y02_RS15430 ENOG4105F8V Hydrolase, tatD family H1Y02_RS15435 ENOG4107QRG dna polymerase iii H1Y02_RS15445 ENOG4105HHA aminodeoxychorismate lyase H1Y02_RS15450 ENOG4105YAZ 4-amino-4-deoxychorismate lyase H1Y02_RS15455 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H1Y02_RS15460 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H1Y02_RS15465 ENOG4105CHR reductase H1Y02_RS15470 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H1Y02_RS15475 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H1Y02_RS15480 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) H1Y02_RS15485 ENOG4105VGS 50s ribosomal protein l32 H1Y02_RS15490 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein H1Y02_RS15495 ENOG4108UHJ MAF-like protein H1Y02_RS15500 ENOG4105EI2 Pseudouridine synthase H1Y02_RS15510 ENOG4107QQB Ribonuclease E H1Y02_RS15515 ENOG4105CR8 Transcriptional regulator H1Y02_RS15520 ENOG4105EQ0 Major Facilitator superfamily H1Y02_RS15525 ENOG4105CJR Integral membrane protein (MviN H1Y02_RS15530 ENOG4105EP9 oxidoreductase H1Y02_RS15540 ENOG4105D9U N-acetyltransferase H1Y02_RS15545 ENOG4105EV4 Multidrug resistance protein mdtH H1Y02_RS15550 ENOG4105F3T (LipO)protein H1Y02_RS15555 ENOG4105EKE dihydroorotase H1Y02_RS15560 ENOG4105MEA DNA damage-inducible protein i H1Y02_RS15565 ENOG4105PVA Biofilm formation regulatory protein BssS H1Y02_RS15575 ENOG4106974 biofilm formation H1Y02_RS15585 ENOG4105D1S lipid A biosynthesis H1Y02_RS15595 ENOG4108W47 Acidic protein msyB H1Y02_RS15600 ENOG4105NAC (LipO)protein H1Y02_RS15615 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) H1Y02_RS15630 ENOG4108UQ5 membrane protein YcdZ H1Y02_RS15635 ENOG4107XHZ cytoplasmic chaperone TorD family protein H1Y02_RS15645 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase H1Y02_RS15665 ENOG4105HEI LysR family (Transcriptional regulator H1Y02_RS15670 ENOG4105EUB pirin domain protein H1Y02_RS15675 ENOG4105CHJ isochorismatase hydrolase H1Y02_RS15685 ENOG4105D5M phosphate starvation-inducible protein H1Y02_RS15690 ENOG4105DBE peroxidase H1Y02_RS15695 ENOG410650H (LipO)protein H1Y02_RS15705 ENOG4105D9N nucleoside H1Y02_RS15715 ENOG4105CK7 Sodium proline symporter H1Y02_RS15720 ENOG4105C26 Dehydrogenase H1Y02_RS15730 ENOG4108R86 Transcriptional regulator H1Y02_RS15750 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H1Y02_RS15755 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) H1Y02_RS15765 ENOG4105C2W permease H1Y02_RS15775 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 H1Y02_RS15790 ENOG4105XH3 H1Y02_RS15810 ENOG4105D6F Phosphatase H1Y02_RS15820 ENOG4105CHR reductase H1Y02_RS15835 ENOG4105CUB amino acid H1Y02_RS15840 ENOG4105CFQ glutamine synthetase H1Y02_RS15845 ENOG4108Z86 Glutamine amidotransferase H1Y02_RS15850 ENOG4107VRI Transcriptional regulator H1Y02_RS15855 ENOG4105C26 Dehydrogenase H1Y02_RS15860 ENOG4105CJP fad dependent oxidoreductase H1Y02_RS15865 ENOG4105EJC lysr family transcriptional regulator H1Y02_RS15870 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H1Y02_RS15875 ENOG4105C94 Transporter H1Y02_RS15880 ENOG4105DVW rieske (2Fe-2S) H1Y02_RS15885 ENOG4105C26 Dehydrogenase H1Y02_RS15890 ENOG4105E3J oxidoreductase H1Y02_RS15895 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H1Y02_RS15900 ENOG4105DM4 PTS System H1Y02_RS15905 ENOG4108YRF PTS System H1Y02_RS15915 ENOG4108AHH pyruvate formate lyase II activase H1Y02_RS15920 ENOG4108XCZ PTS System H1Y02_RS15930 ENOG4106R3P AraC family transcriptional regulator H1Y02_RS15935 ENOG4105BZU Histidine kinase H1Y02_RS15955 ENOG4105BZU Histidine kinase H1Y02_RS15970 ENOG4105F2I Transposase H1Y02_RS15985 ENOG4107QSI ABC, transporter H1Y02_RS15990 ENOG4108MN8 Membrane H1Y02_RS16000 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 H1Y02_RS16005 ENOG4108UQN AraC family transcriptional regulator H1Y02_RS16010 ENOG4108V1U phospholipid-binding protein H1Y02_RS16020 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) H1Y02_RS16025 ENOG4105K4P CoA-binding domain protein H1Y02_RS16035 ENOG41088T4 Helicase IV H1Y02_RS16040 ENOG410901E Membrane H1Y02_RS16045 ENOG4105EM2 membrane H1Y02_RS16050 ENOG4108RZ1 DNA transformation protein H1Y02_RS16065 ENOG4105UYK outer membrane protein a H1Y02_RS16070 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) H1Y02_RS16075 ENOG4105DAN ATP-dependent protease H1Y02_RS16080 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) H1Y02_RS16085 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) H1Y02_RS16090 ENOG4108Q2G (LipO)protein H1Y02_RS16095 ENOG4105DY2 Paraquat-inducible protein b H1Y02_RS16100 ENOG4105F1S paraquat-inducible protein a H1Y02_RS16105 ENOG4105C5H ABC transporter H1Y02_RS16110 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H1Y02_RS16115 ENOG4105QVC MOSC domain-containing protein H1Y02_RS16120 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) H1Y02_RS16130 ENOG4108UZX fmn reductase H1Y02_RS16135 ENOG4105GVF (ABC) transporter H1Y02_RS16140 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) H1Y02_RS16145 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H1Y02_RS16155 ENOG4105CD8 aminopeptidase N H1Y02_RS16160 ENOG4107RH7 Nicotinate phosphoribosyltransferase H1Y02_RS16165 ENOG4105C5S asparaginyl-tRNA synthetase H1Y02_RS16180 ENOG4105ZIT Porin Gram-negative type H1Y02_RS16185 ENOG4105CGF Aromatic amino acid aminotransferase H1Y02_RS16190 ENOG4105C5X domain protein H1Y02_RS16195 ENOG4105EAQ (twin-arginine translocation) pathway signal H1Y02_RS16200 ENOG4105DIT ErfK YbiS YcfS YnhG family protein H1Y02_RS16205 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) H1Y02_RS16210 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) H1Y02_RS16215 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) H1Y02_RS16220 ENOG4106371 Methyltransferase H1Y02_RS16225 ENOG4107S90 membrAne H1Y02_RS16230 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups H1Y02_RS16235 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) H1Y02_RS16240 ENOG4105W49 UPF0434 protein H1Y02_RS16245 ENOG4105T0Z Conserved Protein H1Y02_RS16250 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) H1Y02_RS16255 ENOG4105BZ1 (ABC) transporter H1Y02_RS16260 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 H1Y02_RS16265 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H1Y02_RS16270 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H1Y02_RS16275 ENOG4105CAT Cytidine monophosphate kinase H1Y02_RS16295 ENOG4108BUD transposase H1Y02_RS16315 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H1Y02_RS16320 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H1Y02_RS16325 ENOG4105DKT Transcriptional regulator H1Y02_RS16330 ENOG4108HHA Transketolase H1Y02_RS16335 ENOG4108IUS Transketolase H1Y02_RS16340 ENOG4108TSE Transferase H1Y02_RS16345 ENOG4107RNH Outer membrane receptor FepA H1Y02_RS16350 ENOG4105E93 esterase H1Y02_RS16355 ENOG41085A6 mbth domain-containing protein H1Y02_RS16360 ENOG4105C0W non-ribosomal peptide synthetase H1Y02_RS16365 ENOG4105E0A ABC, transporter H1Y02_RS16370 ENOG4105TVJ transport system, permease H1Y02_RS16375 ENOG4105DQ5 transport system permease protein H1Y02_RS16380 ENOG4105E8G Major facilitator Superfamily H1Y02_RS16385 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein H1Y02_RS16390 ENOG4105E4F Isochorismate synthase H1Y02_RS16395 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H1Y02_RS16400 ENOG4105WQI isochorismatase H1Y02_RS16405 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H1Y02_RS16410 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) H1Y02_RS16415 ENOG4105D22 carbon starvation protein H1Y02_RS16420 ENOG4105VCD cytoplasmic protein H1Y02_RS16435 ENOG4105CHR reductase H1Y02_RS16440 ENOG4107SCQ Iron-containing alcohol dehydrogenase H1Y02_RS16445 ENOG4105C2J ABC transporter H1Y02_RS16450 ENOG4105CNN ABC, transporter H1Y02_RS16465 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) H1Y02_RS16475 ENOG4105D6F Phosphatase H1Y02_RS16480 ENOG4105CXY transporter H1Y02_RS16485 ENOG4105ECY inositol monophosphatase H1Y02_RS16495 ENOG4105DZC cytosine deaminase H1Y02_RS16505 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin H1Y02_RS16520 ENOG4108M3J Dehydrogenase H1Y02_RS16530 ENOG4105CNN ABC, transporter H1Y02_RS16540 ENOG4105C2J ABC transporter H1Y02_RS16555 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) H1Y02_RS16560 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) H1Y02_RS16565 ENOG4105CHM Aminotransferase H1Y02_RS16570 ENOG4105GTN ParB Domain Protein Nuclease H1Y02_RS16575 ENOG4105BZV Phosphoadenosine phosphosulfate reductase H1Y02_RS16580 ENOG4105DQS Transcriptional regulator H1Y02_RS16585 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase H1Y02_RS16590 ENOG4105D3R alkyl hydroperoxide reductase H1Y02_RS16595 ENOG4108JU3 Alkyl hydroperoxide reductase H1Y02_RS16600 ENOG4108U51 Universal stress protein H1Y02_RS16605 ENOG4105NXH GreA GreB family elongation factor H1Y02_RS16610 ENOG4105KTS ribonuclease H1Y02_RS16615 ENOG4105CEE C4-dicarboxylate transporter H1Y02_RS16620 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) H1Y02_RS16640 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H1Y02_RS16645 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H1Y02_RS16650 ENOG41064T2 transcriptional regulator, lysR family H1Y02_RS16660 ENOG4108Z43 UPF0250 protein H1Y02_RS16665 ENOG4105DZ1 carboxypeptidase H1Y02_RS16670 ENOG4105K6T rare lipoprotein A H1Y02_RS16675 ENOG4105CNI cell division protein FtsW H1Y02_RS16680 ENOG4105CJN penicillin-binding protein H1Y02_RS16685 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) H1Y02_RS16690 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) H1Y02_RS16695 ENOG4108TGR phosphatase H1Y02_RS16700 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) H1Y02_RS16705 ENOG4105DJF DNA polymerase III, delta' subunit H1Y02_RS16720 ENOG4107PAI alpha helical protein H1Y02_RS16730 ENOG4105D5K Hemolysin activator protein H1Y02_RS16735 ENOG4105CDA abc transporter atp-binding protein H1Y02_RS16740 ENOG4105DRP amino acid AbC transporter H1Y02_RS16745 ENOG4105EAD ABC transporter H1Y02_RS16750 ENOG4107RP9 extracellular solute-binding protein, family 3 H1Y02_RS16755 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H1Y02_RS16760 ENOG4108JU5 Magnesium and cobalt efflux protein H1Y02_RS16765 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H1Y02_RS16770 ENOG4105C9A Phoh family H1Y02_RS16775 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H1Y02_RS16780 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H1Y02_RS16820 ENOG4105CAQ asparagine synthetase H1Y02_RS16825 ENOG4105D4U had-superfamily hydrolase, subfamily iia H1Y02_RS16830 ENOG4105E2R ROK family H1Y02_RS16835 ENOG4105CE4 GlcNAc 6-P deacetylase H1Y02_RS16840 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) H1Y02_RS16845 ENOG4105CI1 PTS System H1Y02_RS16850 ENOG4105CX6 glutaminyL-tRNA synthetase H1Y02_RS16860 ENOG4105J5J Outer membrane porin H1Y02_RS16865 ENOG4105GX6 (LipO)protein H1Y02_RS16880 ENOG4107EFR Flavocytochrome c H1Y02_RS16885 ENOG4105EF7 Transcriptional regulator H1Y02_RS16890 ENOG41090R7 Ferric uptake H1Y02_RS16895 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) H1Y02_RS16900 ENOG4105NNH LexA regulated protein H1Y02_RS16905 ENOG4105EV9 Alpha Beta Hydrolase H1Y02_RS16910 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) H1Y02_RS16915 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 H1Y02_RS16925 ENOG4105EEX Two component transcriptional regulator (Winged helix family H1Y02_RS16930 ENOG4105C08 Histidine kinase H1Y02_RS16935 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) H1Y02_RS16945 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H1Y02_RS16955 ENOG4105XIQ Protein of unknown function (DUF2517) H1Y02_RS16960 ENOG4105CVP deoxyribo-dipyrimidine photolyase H1Y02_RS16970 ENOG4107QNR UPF0135 protein H1Y02_RS16975 ENOG4105P4J Allophanate hydrolase, subunit 1 H1Y02_RS16980 ENOG4107R7A Allophanate hydrolase subunit 2 H1Y02_RS16995 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) H1Y02_RS17000 ENOG4105BZN citrate synthase H1Y02_RS17005 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit H1Y02_RS17010 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein H1Y02_RS17015 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H1Y02_RS17020 ENOG4105E33 succinate dehydrogenase H1Y02_RS17025 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H1Y02_RS17030 ENOG4105C7S Dehydrogenase H1Y02_RS17035 ENOG4105CMV Succinyl-CoA synthetase subunit beta H1Y02_RS17040 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H1Y02_RS17045 ENOG4105C4M (Ubiquinol oxidase) subunit I H1Y02_RS17050 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H1Y02_RS17060 ENOG4105KJB cyd operon protein YbgE H1Y02_RS17065 ENOG4107YD3 Thioesterase H1Y02_RS17070 ENOG4105E02 MotA TolQ exbB proton channel H1Y02_RS17080 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA H1Y02_RS17080 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA H1Y02_RS17090 ENOG4105KCK Peptidoglycan-associated lipoprotein H1Y02_RS17095 ENOG4105UFD tol-pal system protein YbgF H1Y02_RS17140 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) H1Y02_RS17145 ENOG4106Z1T Nicotinamide Mononucleotide Transporter H1Y02_RS17150 ENOG4105PGM cation diffusion facilitator family transporter H1Y02_RS17155 ENOG4105JND homeobox protein H1Y02_RS17160 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H1Y02_RS17165 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H1Y02_RS17170 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H1Y02_RS17175 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) H1Y02_RS17180 ENOG4105F0Z galactose-1-phosphate uridylyltransferase H1Y02_RS17185 ENOG4105CMR udp-glucose 4-epimerase H1Y02_RS17190 ENOG4105DKW ABC transporter H1Y02_RS17195 ENOG4105F4R Transcriptional regulator mode H1Y02_RS17205 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H1Y02_RS17210 ENOG4105E0C molybdate abc transporter H1Y02_RS17215 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS17220 ENOG4108K4B hydrolase H1Y02_RS17240 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component H1Y02_RS17245 ENOG4105BZU Histidine kinase H1Y02_RS17250 ENOG4108XDN Transcriptional regulator H1Y02_RS17285 ENOG4105ENT Efflux transporter rnd family, mfp subunit H1Y02_RS17290 ENOG4108U51 Universal stress protein H1Y02_RS17300 ENOG4105NBR Pectinesterase H1Y02_RS17305 ENOG4105CI2 imidazolone-5-propionate hydrolase H1Y02_RS17310 ENOG41088SP formiminoglutamate hydrolase H1Y02_RS17325 ENOG4105CGP Urocanate hydratase H1Y02_RS17330 ENOG4105C84 Histidine ammonia-lyase H1Y02_RS17335 ENOG4105C85 amino acid H1Y02_RS17340 ENOG4108V1U phospholipid-binding protein H1Y02_RS17345 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H1Y02_RS17355 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H1Y02_RS17360 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H1Y02_RS17370 ENOG4108IV0 ABC, transporter H1Y02_RS17380 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H1Y02_RS17385 ENOG4105ECM Sensor protein basS pmrB H1Y02_RS17390 ENOG4105XJC Two component transcriptional regulator (Winged helix family H1Y02_RS17395 ENOG4105DIJ Phosphoethanolamine transferase H1Y02_RS17400 ENOG4105CHW UPF0052 protein H1Y02_RS17405 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H1Y02_RS17410 ENOG4108RIR Molybdenum cofactor biosynthesis protein H1Y02_RS17420 ENOG4105M00 molybdopterin converting factor, subunit 1 H1Y02_RS17425 ENOG4108ZAF Molybdopterin H1Y02_RS17430 ENOG4105HFZ Membrane H1Y02_RS17435 ENOG4107UXM Membrane H1Y02_RS17440 ENOG4105DZQ phospholipase D Transphosphatidylase H1Y02_RS17445 ENOG4105X23 Endonuclease Exonuclease phosphatase H1Y02_RS17450 ENOG4105I9U inner membrane protein ybhQ H1Y02_RS17455 ENOG4107QWP ABC-2 type transporter H1Y02_RS17460 ENOG4107QWP ABC-2 type transporter H1Y02_RS17465 ENOG4105CJ1 ABC, transporter H1Y02_RS17470 ENOG4105D0S secretion protein (HlyD H1Y02_RS17480 ENOG4108PZW LysR family Transcriptional regulator H1Y02_RS17490 ENOG4105DJB Major Facilitator Superfamily H1Y02_RS17510 ENOG4105C1J atp-dependent rna helicase H1Y02_RS17515 ENOG4105DVT helicase H1Y02_RS17520 ENOG4108MTB glycosyl transferase family H1Y02_RS17525 ENOG4105VR4 UPF0379 protein ybiJ H1Y02_RS17530 ENOG4105KSC Transcriptional regulator, TraR DksA family H1Y02_RS17540 ENOG4105EW6 flavin reductase domain protein, FMN-binding H1Y02_RS17545 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) H1Y02_RS17550 ENOG4105D8X mechanosensitive ion channel H1Y02_RS17555 ENOG4105CDA abc transporter atp-binding protein H1Y02_RS17560 ENOG4105E5Q amino acid AbC transporter H1Y02_RS17565 ENOG4107R0W ABC transporter H1Y02_RS17570 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction H1Y02_RS17580 ENOG4108T1M outer membrane protein x H1Y02_RS17585 ENOG4108I6E Sulfatase H1Y02_RS17595 ENOG4105KST dependent repressor H1Y02_RS17600 ENOG4105F4P )-transporter H1Y02_RS17605 ENOG4105CS2 ec 3.2.1.21 H1Y02_RS17610 ENOG4108TZY GntR Family Transcriptional Regulator H1Y02_RS17615 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H1Y02_RS17625 ENOG4105C5H ABC transporter H1Y02_RS17635 ENOG4105DPW Major facilitator superfamily MFS_1 H1Y02_RS17640 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS17645 ENOG41072TH Protein of unknown function (DUF1479) H1Y02_RS17650 ENOG4108HCJ Hydrolase H1Y02_RS17660 ENOG4105F1A Pyruvate formate-lyase H1Y02_RS17665 ENOG4105D06 uba thif-type nad fad binding protein H1Y02_RS17670 ENOG4105CVM Molybdenum cofactor synthesis domain protein H1Y02_RS17675 ENOG4105D44 asparaginase H1Y02_RS17680 ENOG4108JQ6 ABC transporter H1Y02_RS17685 ENOG4105DEF Extracellular solute-binding protein, family 5 H1Y02_RS17690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Y02_RS17695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS17700 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) H1Y02_RS17705 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) H1Y02_RS17710 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway H1Y02_RS17715 ENOG4105D8V Glucose sorbosone dehydrogenase H1Y02_RS17720 ENOG4108TGY Glutathione S-transferase H1Y02_RS17725 ENOG4105DZ1 carboxypeptidase H1Y02_RS17730 ENOG4107FB0 transcriptional regulator DeoR family H1Y02_RS17735 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H1Y02_RS17740 ENOG4107QF7 multi-drug H1Y02_RS17745 ENOG4108HCJ Hydrolase H1Y02_RS17750 ENOG4106UW1 Major Facilitator superfamily H1Y02_RS17755 ENOG4108RFG Tetr family transcriptional regulator H1Y02_RS17760 ENOG4105D0C transport protein H1Y02_RS17765 ENOG4105GWF inner membrane protein YbjM H1Y02_RS17770 ENOG41090BQ Glutaredoxin H1Y02_RS17775 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress H1Y02_RS17780 ENOG4108DBC nitroreductase H1Y02_RS17790 ENOG4108RMJ sensory transduction regulator H1Y02_RS17795 ENOG4107RUE extracellular solute-binding protein family 1 H1Y02_RS17800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS17805 ENOG4105F38 ABC transporter, permease H1Y02_RS17810 ENOG4105D38 putrescine abc transporter H1Y02_RS17815 ENOG4105RBQ inner membrane protein ybjO H1Y02_RS17820 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) H1Y02_RS17825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Y02_RS17830 ENOG4105BZU Histidine kinase H1Y02_RS17835 ENOG4106TNF Periplasmic binding protein H1Y02_RS17840 ENOG4105DMR ABC, transporter H1Y02_RS17845 ENOG4105GBT ABC transporter H1Y02_RS17850 ENOG4106PMH Extracellular solute-binding protein family 3 H1Y02_RS17855 ENOG4105E5Z arginine transporter ATP-binding subunit H1Y02_RS17860 ENOG41064MM (LipO)protein H1Y02_RS17865 ENOG4105TDT uncharacterized protein yahO H1Y02_RS17875 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H1Y02_RS17880 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase H1Y02_RS17885 ENOG4105CGD Nad-dependent epimerase dehydratase H1Y02_RS17890 ENOG4105C5W Aldolase H1Y02_RS17895 ENOG4105C7K acetolactate synthase H1Y02_RS17905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H1Y02_RS17915 ENOG4105DWU Membrane H1Y02_RS17920 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H1Y02_RS17925 ENOG4105CPB ATP-dependent endonuclease of the OLD family H1Y02_RS17930 ENOG4105DJY efflux transporter, rnd family, mfp subunit H1Y02_RS17940 ENOG4105VEQ Cold shock protein H1Y02_RS17945 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) H1Y02_RS17950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H1Y02_RS17955 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H1Y02_RS17960 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) H1Y02_RS17965 ENOG4108JJ8 (ABC) transporter H1Y02_RS17970 ENOG4108JJ9 ABC, transporter H1Y02_RS17975 ENOG4105C3M thioredoxin reductase H1Y02_RS17980 ENOG4105EW9 transcriptional regulator AsnC family H1Y02_RS17985 ENOG4105CNU cell division protein FtsK H1Y02_RS17995 ENOG4105D1H recombination factor protein RarA H1Y02_RS18000 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H1Y02_RS18005 ENOG4107QY8 reductase H1Y02_RS18010 ENOG4105QAX Iron-sulfur H1Y02_RS18015 ENOG4107KGK dmso reductase anchor subunit H1Y02_RS18020 ENOG4108ISG Major Facilitator H1Y02_RS18025 ENOG4105F1A Pyruvate formate-lyase H1Y02_RS18030 ENOG4105C6N Formate acetyltransferase H1Y02_RS18035 ENOG4105TMB Formate nitrite transporter H1Y02_RS18045 ENOG4108BUD transposase H1Y02_RS18050 ENOG4105CNN ABC, transporter H1Y02_RS18070 ENOG410810E transcriptional regulator, lysR family H1Y02_RS18075 ENOG4105CUY Mechanosensitive ion channel H1Y02_RS18080 ENOG4108WN0 inhibitor of vertebrate lysozyme H1Y02_RS18085 ENOG4105C94 Transporter H1Y02_RS18100 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) H1Y02_RS18115 ENOG4105JAB phenazine biosynthesis protein, phzf family H1Y02_RS18120 ENOG4105F2I Transposase H1Y02_RS18130 ENOG4108T1W Fimbrial subunit type 3 H1Y02_RS18135 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS18140 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS18150 ENOG4105F2I Transposase H1Y02_RS18155 ENOG4105SUV lipoprotein YgdR H1Y02_RS18165 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein H1Y02_RS18170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Y02_RS18175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS18180 ENOG4105C3U ABC transporter H1Y02_RS18185 ENOG4108JQ7 (ABC) transporter H1Y02_RS18190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H1Y02_RS18195 ENOG4105EMU Dehydrogenase H1Y02_RS18205 ENOG4105GBT ABC transporter H1Y02_RS18210 ENOG4105F2I Transposase H1Y02_RS18215 ENOG4105E5Q amino acid AbC transporter H1Y02_RS18220 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) H1Y02_RS18230 ENOG4105CHM Aminotransferase H1Y02_RS18235 ENOG4105T38 integral membrane protein H1Y02_RS18240 ENOG4105CE7 Amidase, hydantoinase carbamoylase family H1Y02_RS18255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Y02_RS18270 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) H1Y02_RS18275 ENOG4108T58 Mg2 transport protein CorA H1Y02_RS18295 ENOG4105WQ6 Membrane H1Y02_RS18300 ENOG4105HFT AraC family transcriptional regulator H1Y02_RS18310 ENOG410630P Transcriptional regulator H1Y02_RS18315 ENOG4105MSB protein, conserved in bacteria H1Y02_RS18320 ENOG4108RCM Nitroreductase H1Y02_RS18350 ENOG4105CUY Mechanosensitive ion channel H1Y02_RS18355 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS18375 ENOG4105EAA nucleoside H1Y02_RS18380 ENOG4105C85 amino acid H1Y02_RS18385 ENOG4105C26 Dehydrogenase H1Y02_RS18390 ENOG4105CJP fad dependent oxidoreductase H1Y02_RS18400 ENOG4105CUB amino acid H1Y02_RS18410 ENOG4105DGU Histone deacetylase H1Y02_RS18420 ENOG4108UAJ Transcriptional regulator H1Y02_RS18430 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) H1Y02_RS18445 ENOG4105CPC Aldo Keto reductase H1Y02_RS18450 ENOG4105E89 ABC transporter H1Y02_RS18455 ENOG4105CH2 amidohydrolase H1Y02_RS18480 ENOG4105EHG Permease protein H1Y02_RS18485 ENOG4105E0A ABC, transporter H1Y02_RS18490 ENOG4105EFX secretion protein, HlyD family H1Y02_RS18495 ENOG4105KK7 inner membrane protein YiaW H1Y02_RS18505 ENOG4105D7K pfkb domain protein H1Y02_RS18510 ENOG4108M0B Sucrose porin H1Y02_RS18520 ENOG4108HKT sucrose-6-phosphate hydrolase H1Y02_RS18525 ENOG4105WBN Transcriptional regulator (LacI family H1Y02_RS18535 ENOG4108HWV )-transporter H1Y02_RS18540 ENOG4105C2J ABC transporter H1Y02_RS18580 ENOG4105F2I Transposase H1Y02_RS18595 ENOG4105F2I Transposase H1Y02_RS18605 ENOG4105KT5 UmuD protein H1Y02_RS18635 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS18690 ENOG4105TKZ Tail Sheath H1Y02_RS18730 ENOG4105D07 Signal peptide peptidase, SppA H1Y02_RS18765 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 H1Y02_RS18770 ENOG4105KUS lysozyme H1Y02_RS18785 ENOG4105QBX endodeoxyribonuclease RusA H1Y02_RS18795 ENOG4108R1E Serine threonine protein phosphatase 1 H1Y02_RS18800 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 H1Y02_RS18945 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H1Y02_RS18950 ENOG4105WQ3 Rna-binding protein H1Y02_RS18955 ENOG4105C8N cysteinyl-tRNA synthetase H1Y02_RS18960 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H1Y02_RS18965 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) H1Y02_RS18975 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H1Y02_RS18980 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H1Y02_RS18985 ENOG4105C5B carbamate kinase H1Y02_RS18990 ENOG4105G5A Protein of unknown function (DUF2877) H1Y02_RS18995 ENOG4107REC cytoplasmic protein H1Y02_RS19000 ENOG4107R1Q Membrane protein FdrA H1Y02_RS19010 ENOG4105F2I Transposase H1Y02_RS19015 ENOG4105BZW Glycerate kinase H1Y02_RS19020 ENOG4105DTE Xanthine uracil vitamin C permease H1Y02_RS19030 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease H1Y02_RS19040 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H1Y02_RS19045 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H1Y02_RS19050 ENOG41060W2 glyoxylate carboligase H1Y02_RS19085 ENOG4105CV6 ABC transporter, permease H1Y02_RS19090 ENOG4108I0Y (ABC) transporter H1Y02_RS19095 ENOG4108UJV acyl-CoA thioesterase i H1Y02_RS19100 ENOG4105E1F short-chain dehydrogenase reductase H1Y02_RS19105 ENOG4107QR8 Thioredoxin H1Y02_RS19110 ENOG4105C4B ABC transporter, permease H1Y02_RS19115 ENOG41083J0 (ABC) transporter H1Y02_RS19120 ENOG4107QX8 SPFH domain, Band 7 family protein H1Y02_RS19125 ENOG4105G5H Membrane H1Y02_RS19130 ENOG4108Z6Z Transcriptional regulator H1Y02_RS19135 ENOG4105C59 p-type ATPase H1Y02_RS19140 ENOG4105MBR gumn family H1Y02_RS19145 ENOG4108Z66 YbaK ebsC protein H1Y02_RS19150 ENOG4105CGH 5'-nucleotidase H1Y02_RS19155 ENOG4105EU0 Major facilitator Superfamily H1Y02_RS19160 ENOG4105CKD glutathione-regulated potassium-efflux system protein H1Y02_RS19165 ENOG4107RE1 Inosine-guanosine kinase H1Y02_RS19175 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H1Y02_RS19180 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H1Y02_RS19185 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H1Y02_RS19190 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H1Y02_RS19195 ENOG4107QMP dna polymerase iii subunits gamma and tau H1Y02_RS19205 ENOG4105WD1 Membrane H1Y02_RS19210 ENOG4108URS primosomal replication protein n'' H1Y02_RS19215 ENOG4106428 Protein of unknown function (DUF2496) H1Y02_RS19220 ENOG4105DNE Transposase H1Y02_RS19225 ENOG4105EGS Mechanosensitive ion channel H1Y02_RS19230 ENOG4107XI7 Tetr family transcriptional regulator H1Y02_RS19235 ENOG4105C1P efflux transporter, rnd family, mfp subunit H1Y02_RS19240 ENOG4105BZS acriflavin resistance protein H1Y02_RS19245 ENOG4108UKR Biofilm formation regulator YbaJ H1Y02_RS19255 ENOG4108UW5 maltose o-acetyltransferase H1Y02_RS19265 ENOG4105GSJ Inner membrane protein ylaC H1Y02_RS19280 ENOG4105YK5 50S ribosomal protein L36 H1Y02_RS19290 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS19295 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) H1Y02_RS19300 ENOG4105CI1 PTS System H1Y02_RS19305 ENOG4105C4C beta-galactosidase H1Y02_RS19315 ENOG4105EG2 ABC transporter, permease H1Y02_RS19325 ENOG4107FKK extracellular solute-binding protein family 1 H1Y02_RS19335 ENOG41066DG (EAL) domain protein H1Y02_RS19340 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter H1Y02_RS19350 ENOG4108VW9 Membrane H1Y02_RS19380 ENOG41080UX Methyltransferase H1Y02_RS19385 ENOG4108MNP Glycoprotein polysaccharide metabolism H1Y02_RS19390 ENOG4105C29 acyl-CoA thioesterase H1Y02_RS19395 ENOG4105BZU Histidine kinase H1Y02_RS19400 ENOG4108YZA Nitrogen regulatory protein pii H1Y02_RS19405 ENOG4105BZ1 (ABC) transporter H1Y02_RS19410 ENOG4105BZ1 (ABC) transporter H1Y02_RS19415 ENOG4108XM1 transcriptional regulator AsnC family H1Y02_RS19430 ENOG4108NFA extracellular solute-binding protein H1Y02_RS19435 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) H1Y02_RS19440 ENOG4108TGP Thioesterase superfamily protein H1Y02_RS19445 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein H1Y02_RS19450 ENOG4105EIN peptidylprolyl cis-trans isomerase H1Y02_RS19455 ENOG4105K70 DNA-binding protein H1Y02_RS19460 ENOG4105F2I Transposase H1Y02_RS19465 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H1Y02_RS19470 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H1Y02_RS19485 ENOG4105M85 Bola protein H1Y02_RS19490 ENOG4105IEY (LipO)protein H1Y02_RS19495 ENOG4105EYM Major Facilitator superfamily H1Y02_RS19500 ENOG4105E2S oxidase) subunit II H1Y02_RS19505 ENOG4105BZ9 Cytochrome C oxidase, subunit I H1Y02_RS19510 ENOG4105CCU oxidase (Subunit III) H1Y02_RS19515 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) H1Y02_RS19520 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H1Y02_RS19530 ENOG4107HP6 Transcriptional regulator H1Y02_RS19535 ENOG4105E2X shikimate dehydrogenase H1Y02_RS19540 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H1Y02_RS19550 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein H1Y02_RS19560 ENOG4105D2S major facilitator superfamily H1Y02_RS19565 ENOG4105CIB oxidoreductase Domain protein H1Y02_RS19570 ENOG4107RDB Major Facilitator H1Y02_RS19580 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H1Y02_RS19585 ENOG4107S0N DJ-1 family H1Y02_RS19595 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) H1Y02_RS19600 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H1Y02_RS19605 ENOG4105CTB Polyprenyl synthetase H1Y02_RS19615 ENOG4105CPC Aldo Keto reductase H1Y02_RS19620 ENOG4108ZAI phosphatidylglycerophosphatase a H1Y02_RS19625 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H1Y02_RS19630 ENOG4107YIM Involved in the transcription termination process (By similarity) H1Y02_RS19635 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H1Y02_RS19640 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H1Y02_RS19645 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) H1Y02_RS19650 ENOG4108KIC (LipO)protein H1Y02_RS19655 ENOG4105DRB nucleoside-specific channel-forming protein H1Y02_RS19670 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H1Y02_RS19675 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H1Y02_RS19680 ENOG4105VIE preprotein translocase, subunit YajC H1Y02_RS19685 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) H1Y02_RS19690 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H1Y02_RS19705 ENOG4105D3R alkyl hydroperoxide reductase H1Y02_RS19715 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia H1Y02_RS19730 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS19740 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS19750 ENOG4108MGF sugar kinase H1Y02_RS19760 ENOG4105CI2 imidazolone-5-propionate hydrolase H1Y02_RS19770 ENOG4105CHJ isochorismatase hydrolase H1Y02_RS19775 ENOG4105EQ1 Transcriptional regulator H1Y02_RS19780 ENOG4107R28 alpha amylase, catalytic region H1Y02_RS19785 ENOG4105C85 amino acid H1Y02_RS19790 ENOG4105CWM branched-chain amino acid transport system II carrier protein H1Y02_RS19795 ENOG4105BZU Histidine kinase H1Y02_RS19800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Y02_RS19805 ENOG4107RH8 nuclease SbcCD subunit D H1Y02_RS19810 ENOG4105EYH Exonuclease H1Y02_RS19815 ENOG4105DKQ ROK family H1Y02_RS19820 ENOG4105DH7 May be involved in recombination (By similarity) H1Y02_RS19825 ENOG4105NBK UPF0345 protein H1Y02_RS19830 ENOG4105HBA AroM protein H1Y02_RS19835 ENOG4105SS3 H1Y02_RS19840 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H1Y02_RS19845 ENOG4105G4C Periplasmic ligand-binding sensor protein H1Y02_RS19850 ENOG4108UPT UPF0178 protein H1Y02_RS19855 ENOG4105II7 pyrroline-5-carboxylate reductase H1Y02_RS19860 ENOG4105VIF phosphate starvation-inducible protein H1Y02_RS19865 ENOG4105G6Z alkaline phosphatase H1Y02_RS19885 ENOG4105CPF Cell wall formation (By similarity) H1Y02_RS19890 ENOG4105UNH Membrane H1Y02_RS19895 ENOG4105FR5 inner membrane protein YaiY H1Y02_RS19900 ENOG4107QS8 (LipO)protein H1Y02_RS19905 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 H1Y02_RS19915 ENOG4107R6D beta-lactam binding protein AmpH H1Y02_RS19920 ENOG4105D52 delta-aminolevulinic acid dehydratase H1Y02_RS19930 ENOG4105E2B Taurine dioxygenase H1Y02_RS19935 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H1Y02_RS19940 ENOG4108ETV ABC transporter H1Y02_RS19945 ENOG4106FTQ Taurine ABC transporter, periplasmic H1Y02_RS19950 ENOG4107QK5 Homocysteine s-methyltransferase H1Y02_RS19955 ENOG4108IQI permease H1Y02_RS19965 ENOG4105CUB amino acid H1Y02_RS19970 ENOG4105CPD ethanolamine ammonia-lyase H1Y02_RS19975 ENOG4107FQ9 ethanolamine ammonia-lyase H1Y02_RS19990 ENOG4105C32 Amino acid ABC transporter (Permease) H1Y02_RS19995 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H1Y02_RS20000 ENOG4105C0Z ABC transporter H1Y02_RS20005 ENOG4108IV0 ABC, transporter H1Y02_RS20015 ENOG4105CT1 (ABC) transporter H1Y02_RS20020 ENOG4105CDA abc transporter atp-binding protein H1Y02_RS20025 ENOG4105E5Q amino acid AbC transporter H1Y02_RS20030 ENOG4105DRP amino acid AbC transporter H1Y02_RS20040 ENOG4106PYX Receptor H1Y02_RS20045 ENOG4108N3D putative enzyme H1Y02_RS20050 ENOG4108NN8 Fimbrial protein H1Y02_RS20055 ENOG4108GWT fimbrillin MatB H1Y02_RS20060 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon H1Y02_RS20070 ENOG4105EHI Phosphonate ABC transporter, periplasmic H1Y02_RS20080 ENOG4105S7S phosphonate abc transporter H1Y02_RS20095 ENOG4108QBX (LipO)protein H1Y02_RS20100 ENOG4105FCK Membrane H1Y02_RS20125 ENOG4107R0V Pyruvate dehydrogenase H1Y02_RS20130 ENOG4105CPP Dehydrogenase, E1 component H1Y02_RS20140 ENOG4107QN2 dihydrolipoyl dehydrogenase H1Y02_RS20150 ENOG41061GT Aldolase H1Y02_RS20160 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS20170 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS20175 ENOG4105CMG Carbohydrate kinase H1Y02_RS20180 ENOG4105CHR reductase H1Y02_RS20185 ENOG4108JQ1 Dehydrogenase H1Y02_RS20190 ENOG4105DT3 PTS system, galactitol-specific IIc component H1Y02_RS20195 ENOG4108TGY Glutathione S-transferase H1Y02_RS20200 ENOG4105DTA methyltransferase H1Y02_RS20205 ENOG4105YCT UPF0386 protein H1Y02_RS20215 ENOG4105D5U fad dependent oxidoreductase H1Y02_RS20220 ENOG4105C26 Dehydrogenase H1Y02_RS20225 ENOG4108JPW Aminotransferase H1Y02_RS20230 ENOG4105C85 amino acid H1Y02_RS20235 ENOG4108PVQ transcriptional regulator H1Y02_RS20240 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) H1Y02_RS20245 ENOG4105V1F Fermentation respiration switch protein H1Y02_RS20250 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) H1Y02_RS20255 ENOG4105CIN aminoacyl-histidine dipeptidase H1Y02_RS20260 ENOG4108HYG acetyltransferase H1Y02_RS20265 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H1Y02_RS20280 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) H1Y02_RS20285 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H1Y02_RS20290 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H1Y02_RS20295 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H1Y02_RS20300 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H1Y02_RS20310 ENOG4105F7V ErfK ybiS ycfS ynhG family protein H1Y02_RS20315 ENOG4105E7A Glutamine amidotransferase H1Y02_RS20320 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H1Y02_RS20325 ENOG4107QPN acyl-Coa dehydrogenase H1Y02_RS20330 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H1Y02_RS20340 ENOG4108VP3 Lysine exporter protein (LysE YggA) H1Y02_RS20345 ENOG41090KR LysR family transcriptional Regulator H1Y02_RS20355 ENOG4107RZZ dna polymerase iii epsilon subunit H1Y02_RS20365 ENOG4105D1A Methyltransferase H1Y02_RS20370 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H1Y02_RS20375 ENOG4105E9H Lytic Murein transglycosylase H1Y02_RS20380 ENOG4105F2W methyltransferase H1Y02_RS20390 ENOG4105F27 Major Facilitator H1Y02_RS20395 ENOG4105HEI LysR family (Transcriptional regulator H1Y02_RS20400 ENOG4105CV8 reductase H1Y02_RS20435 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H1Y02_RS20440 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS20445 ENOG4108UMI ABC transporter, permease H1Y02_RS20450 ENOG4105D01 (LipO)protein H1Y02_RS20455 ENOG4108R8X outer membrane lipoprotein H1Y02_RS20460 ENOG4108R96 Methyltransferase, YaeB family H1Y02_RS20465 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H1Y02_RS20475 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion H1Y02_RS20480 ENOG4108YZN class I peptide chain release factor H1Y02_RS20485 ENOG4108VWS Yaeq family H1Y02_RS20490 ENOG4105W1I UPF0253 protein H1Y02_RS20495 ENOG4105M1T rho-binding antiterminator H1Y02_RS20500 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H1Y02_RS20505 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase H1Y02_RS20510 ENOG4105CXN decarboxylase H1Y02_RS20515 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H1Y02_RS20520 ENOG4105C0B DNA polymerase III (alpha subunit) H1Y02_RS20525 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H1Y02_RS20530 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H1Y02_RS20540 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H1Y02_RS20545 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H1Y02_RS20550 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) H1Y02_RS20560 ENOG4105DZP Membrane-associated zinc metalloprotease H1Y02_RS20565 ENOG4105KNE Phosphatidate cytidylyltransferase H1Y02_RS20585 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H1Y02_RS20590 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) H1Y02_RS20595 ENOG4105CE9 30S ribosomal protein S2 H1Y02_RS20600 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H1Y02_RS20605 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) H1Y02_RS20610 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) H1Y02_RS20615 ENOG4108T8E UPF0325 protein H1Y02_RS20620 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR H1Y02_RS20625 ENOG4105C0H protease H1Y02_RS20630 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein H1Y02_RS20635 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) H1Y02_RS20640 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) H1Y02_RS20645 ENOG4105EN6 Membrane H1Y02_RS20650 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H1Y02_RS20655 ENOG4105CMQ Chloride channel H1Y02_RS20660 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H1Y02_RS20665 ENOG4105S6R Iron-hydroxamate transporter permease subunit H1Y02_RS20670 ENOG4105J76 Periplasmic binding protein H1Y02_RS20675 ENOG4105E0A ABC, transporter H1Y02_RS20680 ENOG4105E0K tonB-dependent siderophore receptor H1Y02_RS20685 ENOG4105BZ4 penicillin-binding protein H1Y02_RS20775 ENOG4105CQ7 ATP-dependent helicase H1Y02_RS20780 ENOG4107XID 2'-5' rna ligase H1Y02_RS20785 ENOG4105PW4 Sugar fermentation stimulation protein homolog H1Y02_RS20790 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters H1Y02_RS20800 ENOG4105DJ0 Poly(A) Polymerase H1Y02_RS20805 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H1Y02_RS20820 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H1Y02_RS20825 ENOG4107BJW polysaccharide deacetylase H1Y02_RS20830 ENOG4108YTN IIa component H1Y02_RS20835 ENOG4105E3A (ABC) transporter H1Y02_RS20840 ENOG4105DA5 (ABC) transporter H1Y02_RS20845 ENOG41077A9 carbonic anhydrase H1Y02_RS20850 ENOG4108UGV hypoxanthine phosphoribosyltransferase H1Y02_RS20880 ENOG4105PTU response to oxidative stress H1Y02_RS20960 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS20980 ENOG4105XB7 anti-repressor protein H1Y02_RS21010 ENOG4105DZG Dehydrogenase H1Y02_RS21015 ENOG4105E3B Multicopper oxidase H1Y02_RS21020 ENOG4108ZRK uncharacterized protein yacC H1Y02_RS21040 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) H1Y02_RS21050 ENOG4107QIJ Aconitate hydratase 2 H1Y02_RS21055 ENOG4108NST exported protein H1Y02_RS21070 ENOG4107QN2 dihydrolipoyl dehydrogenase H1Y02_RS21075 ENOG4107QSN dihydrolipoamide acetyltransferase H1Y02_RS21080 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H1Y02_RS21085 ENOG41073TP transcriptional regulator H1Y02_RS21090 ENOG4105C85 amino acid H1Y02_RS21095 ENOG4105CT4 transporter H1Y02_RS21100 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) H1Y02_RS21105 ENOG4106A72 regulatory protein AmpE H1Y02_RS21115 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H1Y02_RS21120 ENOG4108ZUW Major pilin subunit H1Y02_RS21125 ENOG4107QHF type ii secretion system protein e H1Y02_RS21130 ENOG4105D7Q type ii secretion system H1Y02_RS21135 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H1Y02_RS21140 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H1Y02_RS21155 ENOG4105M6F mutator MutT protein H1Y02_RS21160 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H1Y02_RS21165 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) H1Y02_RS21170 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H1Y02_RS21175 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H1Y02_RS21180 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H1Y02_RS21185 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) H1Y02_RS21200 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H1Y02_RS21205 ENOG4105CNI cell division protein FtsW H1Y02_RS21215 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H1Y02_RS21220 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) H1Y02_RS21225 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H1Y02_RS21230 ENOG4105CJN penicillin-binding protein H1Y02_RS21235 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H1Y02_RS21240 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H1Y02_RS21250 ENOG4107B7Y DNA-binding transcriptional regulator FruR H1Y02_RS21255 ENOG4108ZP8 Acetolactate synthase small subunit H1Y02_RS21260 ENOG4105C7K acetolactate synthase H1Y02_RS21270 ENOG4105F2I Transposase H1Y02_RS21275 ENOG4105F2I Transposase H1Y02_RS21285 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) H1Y02_RS21295 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H1Y02_RS21300 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H1Y02_RS21310 ENOG4105E2X shikimate dehydrogenase H1Y02_RS21315 ENOG4105EMV Major Facilitator H1Y02_RS21320 ENOG4105FF2 Type I DHQase H1Y02_RS21325 ENOG4105C5Q Transcriptional regulator H1Y02_RS21330 ENOG4105DJB Major Facilitator Superfamily H1Y02_RS21335 ENOG4105S8Q sugar efflux transporter H1Y02_RS21355 ENOG4106SMU thiamine transporter membrane protein H1Y02_RS21365 ENOG4108KF1 Membrane H1Y02_RS21370 ENOG41063TF transcriptional regulator (AraC H1Y02_RS21380 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) H1Y02_RS21385 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H1Y02_RS21390 ENOG4105CQ2 DNA polymerase H1Y02_RS21400 ENOG4105D3G Pseudouridine synthase H1Y02_RS21410 ENOG4105D2K citrate carrier protein H1Y02_RS21415 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H1Y02_RS21420 ENOG4106YYS transcriptional regulatory protein H1Y02_RS21425 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) H1Y02_RS21430 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) H1Y02_RS21440 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) H1Y02_RS21445 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H1Y02_RS21460 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H1Y02_RS21465 ENOG4105CKD glutathione-regulated potassium-efflux system protein H1Y02_RS21475 ENOG4105M5B (LipO)protein H1Y02_RS21480 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H1Y02_RS21485 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H1Y02_RS21495 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H1Y02_RS21500 ENOG4105EXG Transcriptional regulator H1Y02_RS21510 ENOG4105DU0 nucleoside hydrolase H1Y02_RS21515 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) H1Y02_RS21520 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase H1Y02_RS21535 ENOG4105DTN riboflavin biosynthesis protein ribF H1Y02_RS21545 ENOG41063Z6 transcriptional regulator, lysR family H1Y02_RS21550 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H1Y02_RS21555 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H1Y02_RS21570 ENOG4108QUJ UPF0174 protein YaaW H1Y02_RS21575 ENOG4106HK8 GPR1 FUN34 yaaH family protein H1Y02_RS21580 ENOG4105CSH Transporter H1Y02_RS21585 ENOG4108RIR Molybdenum cofactor biosynthesis protein H1Y02_RS21590 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H1Y02_RS21595 ENOG4105BZG amino acid carrier protein H1Y02_RS21605 ENOG4105D98 threonine synthase H1Y02_RS21610 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) H1Y02_RS21615 ENOG4105CFH Aspartokinase H1Y02_RS21625 ENOG4106FVC RNA methyltransferase H1Y02_RS21630 ENOG410759A H1Y02_RS21635 ENOG41065U4 response regulator H1Y02_RS21640 ENOG4105CT7 inner membrane cred family protein H1Y02_RS21645 ENOG4105EB3 Histidine kinase H1Y02_RS21650 ENOG4105E3W Two component transcriptional regulator (Winged helix family H1Y02_RS21655 ENOG4108RH0 Crea protein H1Y02_RS21660 ENOG4105UEI Transcriptional Regulator AraC Family H1Y02_RS21665 ENOG4105CVJ phosphoglycerate mutase H1Y02_RS21670 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H1Y02_RS21675 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) H1Y02_RS21680 ENOG4107SC1 transglycosylase H1Y02_RS21685 ENOG4105C5H ABC transporter H1Y02_RS21690 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase H1Y02_RS21695 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H1Y02_RS21700 ENOG4105EAC phosphoserine phosphatase H1Y02_RS21705 ENOG41062Z9 Membrane H1Y02_RS21710 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) H1Y02_RS21725 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) H1Y02_RS21735 ENOG4105D9N nucleoside H1Y02_RS21740 ENOG4105EYA deoxyribonuclease H1Y02_RS21745 ENOG4108NRW Phospholipase, patatin family H1Y02_RS21750 ENOG41075IC Protein of unknown function (DUF1328) H1Y02_RS21755 ENOG4105K3G Periplasmic Protein H1Y02_RS21760 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) H1Y02_RS21765 ENOG4105PAD Hydrolase H1Y02_RS21770 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H1Y02_RS21775 ENOG4108WPU DNA polymerase III subunit psi H1Y02_RS21780 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) H1Y02_RS21800 ENOG4105YBH Protein of unknown function (DUF1435) H1Y02_RS21810 ENOG4105F2I Transposase H1Y02_RS21815 ENOG4106TD9 Diguanylate cyclase H1Y02_RS21820 ENOG4108819 ferric iron reductase H1Y02_RS21825 ENOG4105CK1 PTS System H1Y02_RS21830 ENOG4108UIN ybak prolyl-trna synthetase associated region H1Y02_RS21835 ENOG4108T94 DNA-binding transcriptional activator BglJ H1Y02_RS21840 ENOG4108N8T regulatoR H1Y02_RS21845 ENOG4105EZV Transcriptional regulator H1Y02_RS21855 ENOG4105DWK Membrane H1Y02_RS21865 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) H1Y02_RS21870 ENOG4106CVF DNA replication protein H1Y02_RS21875 ENOG4105RI1 glycoprotein receptor H1Y02_RS21885 ENOG4105DNE Transposase H1Y02_RS21890 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H1Y02_RS21900 ENOG4105F3R pts system mannose fructose sorbose family iid H1Y02_RS21905 ENOG4105ETZ PTS System H1Y02_RS21920 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H1Y02_RS21930 ENOG4105XYF acetyltransferase H1Y02_RS21935 ENOG4105DG4 malate L-lactate dehydrogenase H1Y02_RS21940 ENOG4107QTZ amino acid H1Y02_RS21945 ENOG4105CZJ Aldehyde dehydrogenase H1Y02_RS21950 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H1Y02_RS21975 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein H1Y02_RS21980 ENOG4108V8F Transcriptional regulator, MarR family H1Y02_RS21990 ENOG4105ERH Fumarylacetoacetate hydrolase H1Y02_RS22000 ENOG4105C26 Dehydrogenase H1Y02_RS22005 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase H1Y02_RS22020 ENOG4105CNV Aldolase H1Y02_RS22030 ENOG4108NKV transcriptional regulator H1Y02_RS22035 ENOG4105EFA 4-hydroxyphenylacetate H1Y02_RS22040 ENOG4107UWN reductase H1Y02_RS22045 ENOG4105D22 carbon starvation protein H1Y02_RS22050 ENOG4105VCD cytoplasmic protein H1Y02_RS22055 ENOG4105CKI cobalamin synthesis protein H1Y02_RS22070 ENOG4105C26 Dehydrogenase H1Y02_RS22075 ENOG4105DNE Transposase H1Y02_RS22080 ENOG4106AXJ AraC family transcriptional regulator H1Y02_RS22090 ENOG4106BRA Membrane H1Y02_RS22095 ENOG41083G8 Multidrug resistance protein MdtM H1Y02_RS22105 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase H1Y02_RS22110 ENOG4105CIZ coA-substrate-specific enzyme activase H1Y02_RS22125 ENOG4105EFX secretion protein, HlyD family H1Y02_RS22135 ENOG4106DIZ Domain of unknown function (DUF1127) H1Y02_RS22140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H1Y02_RS22165 ENOG41064T2 transcriptional regulator, lysR family H1Y02_RS22190 ENOG4105KNY Microcompartments protein H1Y02_RS22195 ENOG4105KNY Microcompartments protein H1Y02_RS22200 ENOG4105KNY Microcompartments protein H1Y02_RS22205 ENOG4105C0A alcohol dehydrogenase H1Y02_RS22220 ENOG4105C6N Formate acetyltransferase H1Y02_RS22225 ENOG4105F1A Pyruvate formate-lyase H1Y02_RS22230 ENOG4105KNY Microcompartments protein H1Y02_RS22235 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) H1Y02_RS22260 ENOG4105D0S secretion protein (HlyD H1Y02_RS22265 ENOG4105CJ1 ABC, transporter H1Y02_RS22270 ENOG4105CMI transporter H1Y02_RS22305 ENOG4105EZE Cupin 4 family protein H1Y02_RS22310 ENOG4105GR3 Histidine kinase H1Y02_RS22315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Y02_RS22320 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H1Y02_RS22325 ENOG410624V efflux system protein H1Y02_RS22330 ENOG4105EP1 Efflux transporter rnd family, mfp subunit H1Y02_RS22335 ENOG4108IJF Heavy metal efflux pump, CzcA H1Y02_RS22345 ENOG4105QNF Outer membrane lipoprotein H1Y02_RS22350 ENOG4108XDN Transcriptional regulator H1Y02_RS22360 ENOG4107FW0 short-chain dehydrogenase reductase H1Y02_RS22375 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H1Y02_RS22395 ENOG4107SEY Conserved Protein H1Y02_RS22400 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) H1Y02_RS22405 ENOG4105C93 Xylose Isomerase H1Y02_RS22410 ENOG4105CT4 transporter H1Y02_RS22415 ENOG4105DSG hydrolase family 43 H1Y02_RS22470 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS22480 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS22505 ENOG41077A9 carbonic anhydrase H1Y02_RS22510 ENOG4105CHH sulfate transporter H1Y02_RS22515 ENOG4105DQ4 alcohol dehydrogenase H1Y02_RS22525 ENOG4105DRS transport system, permease H1Y02_RS22530 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H1Y02_RS22535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS22545 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) H1Y02_RS22550 ENOG4105F0H myo-inositol catabolism protein H1Y02_RS22555 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) H1Y02_RS22560 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) H1Y02_RS22565 ENOG4105D7K pfkb domain protein H1Y02_RS22570 ENOG4105CHC glucokinase (EC 2.7.1.2) H1Y02_RS22575 ENOG4105DH8 myo-inositol catabolism H1Y02_RS22580 ENOG4105C26 Dehydrogenase H1Y02_RS22590 ENOG4105D7A ATP-binding protein H1Y02_RS22595 ENOG4108K5H permease YjgP YjgQ family protein H1Y02_RS22600 ENOG4108M8S permease YjgP YjgQ family protein H1Y02_RS22605 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H1Y02_RS22610 ENOG4105MYG DNA polymerase iii, chi subunit H1Y02_RS22615 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H1Y02_RS22620 ENOG4108MJ3 acetyltransferase H1Y02_RS22625 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase H1Y02_RS22630 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) H1Y02_RS22640 ENOG4105XEP YhcH YjgK YiaL family protein H1Y02_RS22655 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) H1Y02_RS22660 ENOG4105KME endoribonuclease L-psp H1Y02_RS22670 ENOG4105D4X repressor H1Y02_RS22675 ENOG4105C5Y PTS System H1Y02_RS22680 ENOG4105CG3 alpha amylase, catalytic region H1Y02_RS22685 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase H1Y02_RS22690 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) H1Y02_RS22695 ENOG4105K4U addiction module toxin, RelE StbE family H1Y02_RS22705 ENOG4105EMD TRANSCRIPTIONal H1Y02_RS22710 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) H1Y02_RS22725 ENOG41069H0 dihydroorotase EC 3.5.2.3 H1Y02_RS22755 ENOG4108XVM Cytochrome b(562) H1Y02_RS22760 ENOG4105CMS peptidase U62, modulator of DNA gyrase H1Y02_RS22765 ENOG4105N42 UPF0307 protein H1Y02_RS22780 ENOG4105DFU Cell wall formation (By similarity) H1Y02_RS22785 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 H1Y02_RS22790 ENOG41062B0 ABC transporter, permease H1Y02_RS22795 ENOG4107R9N ABC transporter H1Y02_RS22800 ENOG4105C2J ABC transporter H1Y02_RS22805 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator H1Y02_RS22810 ENOG4105F0N pyrophosphate phospho-hydrolase H1Y02_RS22820 ENOG4108ZHD aig2 family H1Y02_RS22825 ENOG4105MA0 exported protein H1Y02_RS22830 ENOG4105CFU surface antigen H1Y02_RS22840 ENOG4105C37 (CBS) domain H1Y02_RS22850 ENOG4105C4C beta-galactosidase H1Y02_RS22860 ENOG41061GZ Protein of unknown function (DUF1107) H1Y02_RS22865 ENOG4108UUE Transcriptional regulator H1Y02_RS22870 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase H1Y02_RS22875 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic H1Y02_RS22880 ENOG4105KVH Transcriptional regulator H1Y02_RS22885 ENOG4105ECR NmrA family H1Y02_RS22895 ENOG4105DXC membrane H1Y02_RS22900 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) H1Y02_RS22910 ENOG4108V1T peptidylprolyl cis-trans isomerase H1Y02_RS22915 ENOG4105FHY Opacity-associated protein A H1Y02_RS22925 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H1Y02_RS22930 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) H1Y02_RS22935 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) H1Y02_RS22940 ENOG4105KIT UPF0379 protein yjfY H1Y02_RS22965 ENOG4106ETB IIa component H1Y02_RS22975 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC H1Y02_RS22990 ENOG4108MXZ Esterase H1Y02_RS22995 ENOG4105WSB biofilm stress and motility protein A H1Y02_RS23000 ENOG4105S17 UPF0379 protein yjfN H1Y02_RS23005 ENOG4105CSU acyl-Coa dehydrogenase H1Y02_RS23010 ENOG4105C2N RNA methyltransferase TrmH family group 3 H1Y02_RS23015 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H1Y02_RS23020 ENOG4105KPV Transcriptional regulator H1Y02_RS23040 ENOG4105EPW hflc protein H1Y02_RS23045 ENOG4107QJR hflk protein H1Y02_RS23050 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H1Y02_RS23060 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H1Y02_RS23065 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H1Y02_RS23070 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H1Y02_RS23075 ENOG4105K8N protein family UPF0079, ATPase H1Y02_RS23080 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H1Y02_RS23085 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H1Y02_RS23105 ENOG4106TNF Periplasmic binding protein H1Y02_RS23110 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) H1Y02_RS23115 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H1Y02_RS23120 ENOG4105DJ4 phosphatidylserine decarboxylase H1Y02_RS23125 ENOG4105EGS Mechanosensitive ion channel H1Y02_RS23135 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) H1Y02_RS23140 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H1Y02_RS23145 ENOG4105E33 succinate dehydrogenase H1Y02_RS23155 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) H1Y02_RS23165 ENOG4105KPY Small multidrug resistance protein H1Y02_RS23175 ENOG4107PEH Entericidin EcnA/B family H1Y02_RS23180 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H1Y02_RS23185 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H1Y02_RS23200 ENOG4108NAE Fimbrial chaperone protein H1Y02_RS23205 ENOG4105CW0 outer membrane usher protein H1Y02_RS23220 ENOG4108MBX Secretion Protein H1Y02_RS23225 ENOG4108JJA ABC, transporter H1Y02_RS23235 ENOG4108ZVF (LipO)protein H1Y02_RS23240 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H1Y02_RS23250 ENOG4105DVH amino acid H1Y02_RS23255 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 H1Y02_RS23260 ENOG4108IJ0 Aspartate ammonia-lyase H1Y02_RS23265 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H1Y02_RS23275 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) H1Y02_RS23280 ENOG4108SIC Transcriptional regulator H1Y02_RS23305 ENOG4108TUY outer membrane protein PgaA H1Y02_RS23310 ENOG4107BJW polysaccharide deacetylase H1Y02_RS23315 ENOG4105CND Glycosyl transferase, family 2 H1Y02_RS23330 ENOG4108ZCF integral membrane protein H1Y02_RS23335 ENOG4105DVC DnaJ domain protein H1Y02_RS23355 ENOG4105CT4 transporter H1Y02_RS23360 ENOG4105F8D glycoside hydrolase family 4 H1Y02_RS23365 ENOG4108K2B transcriptional regulator H1Y02_RS23370 ENOG4105CSH Transporter H1Y02_RS23375 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H1Y02_RS23380 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase H1Y02_RS23385 ENOG4107RJJ Transcriptional regulator H1Y02_RS23390 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG H1Y02_RS23395 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH H1Y02_RS23400 ENOG4105EKV Phosphonate metabolism protein H1Y02_RS23405 ENOG4105FT8 Phosphonate metabolism H1Y02_RS23410 ENOG4105ENV phosphonate C-P lyase system protein PhnK H1Y02_RS23415 ENOG4105HRV phosphonate c-p lyase system protein phnl H1Y02_RS23420 ENOG4105FD8 phosphonate metabolism protein PhnM H1Y02_RS23425 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) H1Y02_RS23430 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein H1Y02_RS23440 ENOG4105BZU Histidine kinase H1Y02_RS23445 ENOG4105C2J ABC transporter H1Y02_RS23450 ENOG4105CNN ABC, transporter H1Y02_RS23455 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H1Y02_RS23475 ENOG41082ND Uncharacterized protein yjcO H1Y02_RS23480 ENOG4105CK2 sodium dicarboxylate symporter H1Y02_RS23490 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H1Y02_RS23495 ENOG41062QD Membrane H1Y02_RS23500 ENOG4107QN1 sodium solute H1Y02_RS23515 ENOG4105CW0 outer membrane usher protein H1Y02_RS23520 ENOG4108VCD Chaperone H1Y02_RS23525 ENOG4105MX3 Fimbrial H1Y02_RS23530 ENOG41067MG lrgb family H1Y02_RS23540 ENOG4105CMU LysR family (Transcriptional regulator H1Y02_RS23545 ENOG4105EEQ Na H antiporter H1Y02_RS23550 ENOG4105C7N Xanthine uracil vitamin C permease H1Y02_RS23555 ENOG4108K3A Glutathione S-transferase H1Y02_RS23560 ENOG4108Z4X TRANSCRIPTIONal H1Y02_RS23565 ENOG4108W3Q Transcriptional regulator H1Y02_RS23570 ENOG4108M8H domain protein H1Y02_RS23575 ENOG4105PMV Membrane H1Y02_RS23595 ENOG4108IJ9 (ABC) transporter H1Y02_RS23600 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H1Y02_RS23605 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS23610 ENOG4105ECY inositol monophosphatase H1Y02_RS23620 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H1Y02_RS23630 ENOG4108DMH HTH_ARAC H1Y02_RS23635 ENOG4107RNH Outer membrane receptor FepA H1Y02_RS23645 ENOG4108UUM single-stranded DNA-binding protein H1Y02_RS23650 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H1Y02_RS23655 ENOG4105MSB protein, conserved in bacteria H1Y02_RS23660 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme H1Y02_RS23670 ENOG4105CGF Aromatic amino acid aminotransferase H1Y02_RS23675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H1Y02_RS23680 ENOG4105CDU Replicative dna helicase H1Y02_RS23685 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H1Y02_RS23690 ENOG4105P4Z Phage shock protein G H1Y02_RS23695 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H1Y02_RS23705 ENOG4105MYN Zinc uptake regulation protein H1Y02_RS23710 ENOG4105VDW Csbd family H1Y02_RS23715 ENOG4107R73 Mate efflux family protein H1Y02_RS23725 ENOG41080IJ Diacylglycerol kinase H1Y02_RS23730 ENOG4105E55 glycerol-3-phosphate acyltransferase H1Y02_RS23735 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) H1Y02_RS23740 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) H1Y02_RS23745 ENOG4107W52 maltose operon periplasmic protein H1Y02_RS23750 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) H1Y02_RS23755 ENOG4108IJ9 (ABC) transporter H1Y02_RS23760 ENOG4107FKK extracellular solute-binding protein family 1 H1Y02_RS23765 ENOG4105D56 permease protein H1Y02_RS23770 ENOG4105EG2 ABC transporter, permease H1Y02_RS23780 ENOG4105F2I Transposase H1Y02_RS23785 ENOG4105F2I Transposase H1Y02_RS23790 ENOG4105CEM UPF0597 protein H1Y02_RS23805 ENOG4105KME endoribonuclease L-psp H1Y02_RS23815 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H1Y02_RS23825 ENOG4105CFH Aspartokinase H1Y02_RS23830 ENOG4105C09 Bile acid H1Y02_RS23845 ENOG4108ZR5 Conserved Protein H1Y02_RS23850 ENOG4105FE9 pseudouridine synthase H1Y02_RS23860 ENOG4105EAM Na Pi-cotransporter H1Y02_RS23865 ENOG4105C3R Methionine synthase H1Y02_RS23870 ENOG41069M3 Transcriptional regulator H1Y02_RS23875 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) H1Y02_RS23880 ENOG4108I9X Isocitrate lyase H1Y02_RS23885 ENOG4107QP3 malate synthase g H1Y02_RS23890 ENOG4105CVG Homoserine O-transsuccinylase H1Y02_RS23895 ENOG4105K5X acetyltransferase H1Y02_RS23925 ENOG4105C12 Phosphoribosylglycinamide synthetase H1Y02_RS23935 ENOG4105BZU Histidine kinase H1Y02_RS23940 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism H1Y02_RS23945 ENOG4108T8B Protein of unknown function (DUF1481) H1Y02_RS23950 ENOG4105K70 DNA-binding protein H1Y02_RS23955 ENOG4105R2J Conserved Protein H1Y02_RS23960 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) H1Y02_RS23965 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H1Y02_RS23970 ENOG4105E09 nadh pyrophosphatase H1Y02_RS23975 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) H1Y02_RS23985 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H1Y02_RS23990 ENOG4105D06 uba thif-type nad fad binding protein H1Y02_RS23995 ENOG4105WHD thiamine biosynthesis protein ThiS H1Y02_RS24000 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) H1Y02_RS24005 ENOG4105D41 biosynthesis protein thiH H1Y02_RS24030 ENOG4108X9F tail fiber protein H1Y02_RS24040 ENOG4105F2I Transposase H1Y02_RS24115 ENOG4105EFV Major head subunit H1Y02_RS24135 ENOG4108QUU Morphogenesis Protein H1Y02_RS24140 ENOG4105QIB mu-like prophage Flumu protein gp29 H1Y02_RS24190 ENOG4105NVB glycoside hydrolase, family 19 H1Y02_RS24220 ENOG4108R7K Metal Dependent Phosphohydrolase H1Y02_RS24260 ENOG4108WTW DNA transposition protein H1Y02_RS24270 ENOG4105R8V Transcriptional regulator H1Y02_RS24295 ENOG4105VCP PTS System H1Y02_RS24300 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H1Y02_RS24305 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H1Y02_RS24310 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H1Y02_RS24315 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) H1Y02_RS24320 ENOG4108VZM 50s ribosomal protein L10 H1Y02_RS24325 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) H1Y02_RS24330 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) H1Y02_RS24335 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H1Y02_RS24340 ENOG4105PM1 preprotein translocase subunit SecE H1Y02_RS24345 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H1Y02_RS24375 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase H1Y02_RS24380 ENOG4105D4A Cell wall formation (By similarity) H1Y02_RS24410 ENOG4108RR8 protoporphyrinogen oxidase H1Y02_RS24415 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) H1Y02_RS24420 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H1Y02_RS24435 ENOG4105CHU acetyl-coa acetyltransferase H1Y02_RS24440 ENOG4107QK7 reductase H1Y02_RS24445 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H1Y02_RS24450 ENOG4105MDZ Transcriptional activator rfaH H1Y02_RS24460 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H1Y02_RS24465 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) H1Y02_RS24470 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H1Y02_RS24475 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) H1Y02_RS24480 ENOG4105JC1 sterol-binding domain protein H1Y02_RS24485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H1Y02_RS24490 ENOG4105CGY Dna recombination protein H1Y02_RS24495 ENOG4107SXA Phosphorylase H1Y02_RS24500 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) H1Y02_RS24510 ENOG4105DZ2 Transcriptional regulator H1Y02_RS24515 ENOG4105EMK carboxylate amino acid amine transporter H1Y02_RS24520 ENOG4105DQF Hydrolase H1Y02_RS24525 ENOG4108EUD Lysophospholipase H1Y02_RS24530 ENOG410829K Lysine exporter protein (Lyse ygga) H1Y02_RS24540 ENOG4105CCF Lysine exporter protein (Lyse ygga) H1Y02_RS24545 ENOG4105C9U ATP-dependent DNA helicase RecQ H1Y02_RS24550 ENOG4105HDD phospholipase H1Y02_RS24555 ENOG4108VUY thioesterase Superfamily protein H1Y02_RS24560 ENOG4105FR1 rard protein H1Y02_RS24565 ENOG4107QUT magnesium and cobalt transport protein CorA H1Y02_RS24570 ENOG4105C4R Atp-dependent dna helicase H1Y02_RS24575 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant H1Y02_RS24580 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Y02_RS24585 ENOG4105CT0 Protein of unknown function, DUF484 H1Y02_RS24595 ENOG4105S7Z (LipO)protein H1Y02_RS24600 ENOG4105XQ6 frataxin-like protein H1Y02_RS24605 ENOG4107T0K Adenylate cyclase H1Y02_RS24615 ENOG41076E6 Uroporphyrinogen-III Synthase H1Y02_RS24620 ENOG4105ECF c-methyltransferase H1Y02_RS24625 ENOG410601J HemY protein H1Y02_RS24650 ENOG4105C85 amino acid H1Y02_RS24655 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family H1Y02_RS24660 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) H1Y02_RS24665 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) H1Y02_RS24670 ENOG4105EGZ biosynthesis protein H1Y02_RS24675 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H1Y02_RS24680 ENOG4108WJ1 acetyltransferase H1Y02_RS24685 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H1Y02_RS24690 ENOG4105C1B dTDP-glucose 4-6-dehydratase H1Y02_RS24695 ENOG4107QQG Dehydrogenase H1Y02_RS24700 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H1Y02_RS24705 ENOG4105SFE lipopolysaccharide biosynthesis protein H1Y02_RS24710 ENOG4105ESV Glycosyl transferase, family 4 H1Y02_RS24715 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H1Y02_RS24725 ENOG4105C1J atp-dependent rna helicase H1Y02_RS24730 ENOG4105C9X ppx gppa phosphatase H1Y02_RS24735 ENOG4105C4R Atp-dependent dna helicase H1Y02_RS24740 ENOG4105KQ5 peptidylprolyl cis-trans isomerase H1Y02_RS24745 ENOG4105KQ5 peptidylprolyl cis-trans isomerase H1Y02_RS24750 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H1Y02_RS24755 ENOG4105EMY transcriptional regulator H1Y02_RS24760 ENOG4105C7B Threonine dehydratase H1Y02_RS24765 ENOG4105C01 Dihydroxy-acid dehydratase H1Y02_RS24770 ENOG4105CM2 brancheD-chain amino acid aminotransferase H1Y02_RS24775 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit H1Y02_RS24790 ENOG4105C0P Mg chelatase subunit ChlI H1Y02_RS24795 ENOG4108WFC UPF0438 protein yifE H1Y02_RS24855 ENOG4108Y73 Membrane H1Y02_RS24860 ENOG4105EJ2 Transcriptional regulator H1Y02_RS24865 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) H1Y02_RS24870 ENOG4105C5Q Transcriptional regulator H1Y02_RS24875 ENOG4105CH7 arginosuccinase H1Y02_RS24880 ENOG4105CAS nag kinase H1Y02_RS24885 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H1Y02_RS24900 ENOG4108MEK Metal-binding protein YodA H1Y02_RS24905 ENOG4106R3P AraC family transcriptional regulator H1Y02_RS24915 ENOG4105DCT glycerol dehydrogenase H1Y02_RS24920 ENOG4105SYT Methylenetetrahydrofolate reductase H1Y02_RS24930 ENOG4105CI1 PTS System H1Y02_RS24935 ENOG4107P2S Transcriptional regulator H1Y02_RS24940 ENOG4108KB2 LysR family Transcriptional regulator H1Y02_RS24945 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase H1Y02_RS24950 ENOG4105CFH Aspartokinase H1Y02_RS24955 ENOG4105C28 cystathionine H1Y02_RS24960 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) H1Y02_RS24965 ENOG4105VFB Binds the 23S rRNA (By similarity) H1Y02_RS24970 ENOG4105C25 Primosomal protein n' H1Y02_RS24975 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS24980 ENOG41063M6 Cell Division Protein H1Y02_RS24985 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) H1Y02_RS24995 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H1Y02_RS25000 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) H1Y02_RS25005 ENOG4105CTQ phosphohexokinase H1Y02_RS25010 ENOG41076HS cation diffusion facilitator family transporter H1Y02_RS25155 ENOG4105ED4 portal protein H1Y02_RS25200 ENOG4105DFE Dna adenine methylase H1Y02_RS25250 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Y02_RS25255 ENOG4105FMW periplasmic H1Y02_RS25260 ENOG4105E3W Two component transcriptional regulator (Winged helix family H1Y02_RS25265 ENOG4105E0F Histidine kinase H1Y02_RS25270 ENOG4108RPX mosc domain containing protein H1Y02_RS25275 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H1Y02_RS25285 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) H1Y02_RS25305 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) H1Y02_RS25310 ENOG4105D4B ABC, transporter H1Y02_RS25315 ENOG4105C2J ABC transporter H1Y02_RS25320 ENOG4105CNN ABC, transporter H1Y02_RS25330 ENOG4105C0A alcohol dehydrogenase H1Y02_RS25340 ENOG4108UW5 maltose o-acetyltransferase H1Y02_RS25345 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) H1Y02_RS25390 ENOG4105D2N Aldolase H1Y02_RS25405 ENOG4105CTQ phosphohexokinase H1Y02_RS25415 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H1Y02_RS25425 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H1Y02_RS25430 ENOG4108MG3 formate dehydrogenase H1Y02_RS25435 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) H1Y02_RS25445 ENOG4105SUU thioesterase domain H1Y02_RS25450 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H1Y02_RS25455 ENOG4107S2Z UPF0761 membrane protein H1Y02_RS25460 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 H1Y02_RS25465 ENOG4105R9B Major Facilitator H1Y02_RS25470 ENOG4108KHF Resistance protein H1Y02_RS25475 ENOG4108K85 Transcriptional regulator H1Y02_RS25480 ENOG4105CI3 gtp-binding protein typa H1Y02_RS25485 ENOG4105C5F glutamine synthetase H1Y02_RS25490 ENOG4105CUX Signal transduction histidine kinase H1Y02_RS25495 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H1Y02_RS25500 ENOG4106FIY H1Y02_RS25505 ENOG4105D4P Coproporphyrinogen iii oxidase H1Y02_RS25510 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) H1Y02_RS25520 ENOG4105C2M dna polymerase I H1Y02_RS25525 ENOG4106HNH Acyl-transferase H1Y02_RS25530 ENOG4108Z33 Thiol disulfide Interchange Protein H1Y02_RS25535 ENOG4105E27 serine threonine protein kinase H1Y02_RS25540 ENOG4105PC1 Conserved Protein H1Y02_RS25545 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H1Y02_RS25550 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b H1Y02_RS25575 ENOG4107EJG GntR family transcriptional regulator H1Y02_RS25580 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Y02_RS25585 ENOG4105ETE Transcriptional regulator (LacI family H1Y02_RS25590 ENOG4108RVA ribokinase H1Y02_RS25595 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H1Y02_RS25600 ENOG4105CNN ABC, transporter H1Y02_RS25605 ENOG4105C2J ABC transporter H1Y02_RS25615 ENOG4105DFH Transport of potassium into the cell (By similarity) H1Y02_RS25630 ENOG4105CU9 asparagine synthetase A H1Y02_RS25635 ENOG4108VVK transcriptional Regulator, AsnC H1Y02_RS25640 ENOG4105QTB Flavodoxin H1Y02_RS25645 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H1Y02_RS25655 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation H1Y02_RS25680 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H1Y02_RS25685 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H1Y02_RS25690 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H1Y02_RS25695 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H1Y02_RS25700 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H1Y02_RS25705 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H1Y02_RS25710 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H1Y02_RS25715 ENOG4105C8U phosphate abc transporter H1Y02_RS25720 ENOG4105E2Z phosphate ABC transporter (Permease H1Y02_RS25725 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H1Y02_RS25740 ENOG4105DYC esterase H1Y02_RS25745 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 H1Y02_RS25750 ENOG4105C7N Xanthine uracil vitamin C permease H1Y02_RS25755 ENOG4108YYH Nadph-dependent fmn reductase H1Y02_RS25760 ENOG4105E8Q phosphopantetheinyl transferase H1Y02_RS25780 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H1Y02_RS25785 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H1Y02_RS25790 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H1Y02_RS25800 ENOG4105VG0 50S ribosomal protein l34 H1Y02_RS25830 ENOG4105EKQ RNA-directed DNA polymerase H1Y02_RS25860 ENOG4105F2I Transposase H1Y02_RS25870 ENOG4105F2I Transposase H1Y02_RS25880 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS25885 ENOG4108T1W Fimbrial subunit type 3 H1Y02_RS25905 ENOG4108BUD transposase H1Y02_RS25910 ENOG4108C33 Resolvase H1Y02_RS25935 ENOG4108BUD transposase H1Y02_RS26075 ENOG4105MPK DNA polymerase III subunit theta H1Y02_RS26095 ENOG4106JQ7 H1Y02_RS26100 ENOG41073YN Protein of unknown function (DUF1380) H1Y02_RS26145 ENOG4107SKI cobyrinic Acid a,c-diamide synthase H1Y02_RS26190 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A H1Y02_RS26200 ENOG4108MBX Secretion Protein H1Y02_RS26205 ENOG4108JJA ABC, transporter H1Y02_RS26220 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS26230 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS26285 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 H1Y02_RS26285 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 H1Y02_RS26330 ENOG4105KF5 hemolysin expression-modulating protein H1Y02_RS26345 ENOG4108BUD transposase H1Y02_RS26420 ENOG4108BUD transposase H1Y02_RS26485 ENOG4107CBI conjugal transfer fertility inhibition protein H1Y02_RS26735 ENOG4108UUM single-stranded DNA-binding protein H1Y02_RS26745 ENOG4105MPK DNA polymerase III subunit theta H1Y02_RS26765 ENOG4106JQ7 H1Y02_RS26865 ENOG4105T95 Thiol disulfide interChange protein H1Y02_RS26900 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 H1Y02_RS26905 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H1Y02_RS26910 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) H1Y02_RS26920 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H1Y02_RS26925 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS26930 ENOG4108BUD transposase H1Y02_RS26940 ENOG4105EQR Transposase IS116 IS110 IS902 H1Y02_RS26955 ENOG41082EK Restriction modification system DNA (Specificity H1Y02_RS26965 ENOG4108BUD transposase H1Y02_RS27025 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Y02_RS27065 ENOG4106RMF ParB family H1Y02_RS27080 ENOG4105CVR type I restriction-modification system H1Y02_RS27145 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A H1Y02_RS27150 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H1Y02_RS27185 ENOG4105BZU Histidine kinase H1Y02_RS27220 ENOG4108BUD transposase H1Y02_RS27250 ENOG410600T transposase H1Y02_RS27320 ENOG4106CQM replication H1Y02_RS27330 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) H1Y02_RS27360 ENOG4107CBI conjugal transfer fertility inhibition protein H1Y02_RS27615 ENOG4105FEQ ParB domain protein nuclease H1Y02_RS27655 ENOG4105MPK DNA polymerase III subunit theta H1Y02_RS27675 ENOG4106JQ7 H1Y02_RS27680 ENOG41073YN Protein of unknown function (DUF1380) H1Y02_RS27820 ENOG4106JQ7 H1Y02_RS27850 ENOG4105FEQ ParB domain protein nuclease H1Y02_RS27880 ENOG4108Z3N Transcriptional regulator