locus-tag	class	description
FH977_RS00020	COG0187	DNA topoisomerase II activity
FH977_RS00025	COG0561	phosphatase activity
FH977_RS00040	COG2186	Transcriptional regulator
FH977_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
FH977_RS00050	COG0800	Aldolase
FH977_RS00060	COG2271	Major facilitator Superfamily
FH977_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
FH977_RS00070	COG5645	(Lipo)protein
FH977_RS00085	COG3645	SOS response
FH977_RS00095	COG2188	Transcriptional regulator
FH977_RS00110	COG2149	membrane
FH977_RS00130	COG2610	gluconate transmembrane transporter activity
FH977_RS00135	COG0583	DNA-binding transcription factor activity
FH977_RS00140	COG2814	Major facilitator Superfamily
FH977_RS00165	COG0028	Belongs to the TPP enzyme family
FH977_RS00170	COG0440	acetolactate synthase activity
FH977_RS00175	COG2197	response regulator
FH977_RS00185	COG2271	Major facilitator Superfamily
FH977_RS00240	COG2188	Transcriptional regulator
FH977_RS00265	COG4580	involved in the transport of maltose and maltodextrins
FH977_RS00270	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH977_RS00275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS00275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS00285	COG1609	Transcriptional regulator
FH977_RS00300	COG0583	DNA-binding transcription factor activity
FH977_RS00305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FH977_RS00310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FH977_RS00315	COG2828	Protein conserved in bacteria
FH977_RS00330	COG0697	spore germination
FH977_RS00335	COG1263	PTS System
FH977_RS00335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS00345	COG2814	Major facilitator Superfamily
FH977_RS00355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH977_RS00380	COG1309	transcriptional regulator
FH977_RS00390	COG0583	DNA-binding transcription factor activity
FH977_RS00415	COG1464	Belongs to the NlpA lipoprotein family
FH977_RS00430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FH977_RS00440	COG1064	alcohol dehydrogenase
FH977_RS00475	COG2211	Major facilitator Superfamily
FH977_RS00480	COG1501	Belongs to the glycosyl hydrolase 31 family
FH977_RS00490	COG1486	melibiose metabolic process
FH977_RS00495	COG1263	PTS System
FH977_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS00500	COG2982	Protein involved in outer membrane biogenesis
FH977_RS00505	COG2233	PERMEase
FH977_RS00510	COG0786	glutamate:sodium symporter activity
FH977_RS00530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FH977_RS00555	COG3152	Membrane
FH977_RS00565	COG1494	fructose-1,6-bisphosphatase
FH977_RS00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FH977_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FH977_RS00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FH977_RS00600	COG2860	membrane
FH977_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FH977_RS00610	COG2169	Transcriptional regulator
FH977_RS00615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FH977_RS00620	COG1561	YicC-like family, N-terminal region
FH977_RS00635	COG1131	(ABC) transporter
FH977_RS00680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FH977_RS00715	COG1519	Transferase
FH977_RS00720	COG1216	Glycosyl transferase, family 2
FH977_RS00725	COG0438	transferase activity, transferring glycosyl groups
FH977_RS00735	COG0859	PFAM glycosyl transferase family 9
FH977_RS00760	COG0859	PFAM glycosyl transferase family 9
FH977_RS00775	COG0156	8-amino-7-oxononanoate synthase activity
FH977_RS00785	COG0463	Glycosyl transferase, family 2
FH977_RS00790	COG2861	carbohydrate metabolic process
FH977_RS00795	COG4942	peptidase
FH977_RS00805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FH977_RS00810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FH977_RS00830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FH977_RS00840	COG2186	Transcriptional regulator
FH977_RS00860	COG3722	fumarate hydratase activity
FH977_RS00880	COG1566	PFAM secretion protein HlyD family protein
FH977_RS00885	COG0625	glutathione transferase activity
FH977_RS00895	COG3276	selenocysteine insertion sequence binding
FH977_RS00900	COG1414	Transcriptional regulator
FH977_RS00905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH977_RS00910	COG3977	Valine--pyruvate aminotransferase
FH977_RS00915	COG0366	Alpha amylase catalytic
FH977_RS00920	COG2992	FlgJ-related protein
FH977_RS00925	COG1609	Transcriptional regulator
FH977_RS00925	COG2207	Transcriptional regulator
FH977_RS00930	COG4214	carbohydrate transport
FH977_RS00940	COG4213	ABC transporter substrate-binding protein
FH977_RS00955	COG4682	membrane
FH977_RS00960	COG4682	membrane
FH977_RS00965	COG3274	enterobacterial common antigen metabolic process
FH977_RS00995	COG1278	Cold shock
FH977_RS01000	COG2944	sequence-specific DNA binding
FH977_RS01005	COG2814	Major facilitator Superfamily
FH977_RS01030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH977_RS01040	COG1609	Transcriptional regulator
FH977_RS01045	COG2885	chlorophyll binding
FH977_RS01050	COG0243	molybdopterin cofactor binding
FH977_RS01055	COG0456	acetyltransferase
FH977_RS01060	COG2818	Glycosylase
FH977_RS01065	COG5571	outer membrane autotransporter
FH977_RS01070	COG2223	nitrite transmembrane transporter activity
FH977_RS01095	COG0747	negative chemotaxis
FH977_RS01100	COG0601	transmembrane transport
FH977_RS01105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH977_RS01110	COG0444	Belongs to the ABC transporter superfamily
FH977_RS01115	COG4608	Belongs to the ABC transporter superfamily
FH977_RS01130	COG2894	cell division
FH977_RS01160	COG2194	sulfuric ester hydrolase activity
FH977_RS01190	COG1215	transferase activity, transferring glycosyl groups
FH977_RS01195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FH977_RS01200	COG3118	belongs to the thioredoxin family
FH977_RS01200	COG0457	Tetratricopeptide repeat
FH977_RS01205	COG2200	EAL domain
FH977_RS01205	COG2199	diguanylate cyclase activity
FH977_RS01215	COG0612	Peptidase, M16
FH977_RS01230	COG2982	Protein involved in outer membrane biogenesis
FH977_RS01235	COG0477	Major facilitator Superfamily
FH977_RS01240	COG1295	ribonuclease BN
FH977_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH977_RS01265	COG1454	alcohol dehydrogenase
FH977_RS01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FH977_RS01280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FH977_RS01285	COG0671	phosphoesterase, PA-phosphatase related
FH977_RS01305	COG0589	response to stress
FH977_RS01315	COG0306	phosphate transporter
FH977_RS01320	COG2081	HI0933 family
FH977_RS01325	COG2239	Acts as a magnesium transporter
FH977_RS01335	COG1124	(ABC) transporter
FH977_RS01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH977_RS01350	COG0601	transmembrane transport
FH977_RS01355	COG0747	negative chemotaxis
FH977_RS01365	COG3479	Phenolic acid decarboxylase
FH977_RS01410	COG0477	Major facilitator Superfamily
FH977_RS01420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FH977_RS01435	COG3714	YhhN family
FH977_RS01445	COG3776	membrane
FH977_RS01450	COG0742	ribosomal rna small subunit methyltransferase
FH977_RS01455	COG0552	protein localization to endoplasmic reticulum
FH977_RS01460	COG2884	Cell division ATP-binding protein ftsE
FH977_RS01465	COG2177	Part of the ABC transporter FtsEX involved in
FH977_RS01480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH977_RS01490	COG0683	leucine binding
FH977_RS01505	COG0683	leucine binding
FH977_RS01510	COG0559	Belongs to the binding-protein-dependent transport system permease family
FH977_RS01560	COG0584	glycerophosphoryl diester phosphodiesterase
FH977_RS01570	COG0405	Gamma-glutamyltransferase
FH977_RS01575	COG1247	-acetyltransferase
FH977_RS01585	COG0673	inositol 2-dehydrogenase activity
FH977_RS01590	COG1741	Belongs to the pirin family
FH977_RS01595	COG1609	Transcriptional regulator
FH977_RS01600	COG3265	gluconokinase activity
FH977_RS01605	COG2610	gluconate transmembrane transporter activity
FH977_RS01615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FH977_RS01640	COG0058	SHG alpha-glucan phosphorylase activity
FH977_RS01655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FH977_RS01670	COG1349	DNA-binding transcription factor activity
FH977_RS01680	COG0058	SHG alpha-glucan phosphorylase activity
FH977_RS01685	COG1640	4-alpha-glucanotransferase
FH977_RS01690	COG2610	gluconate transmembrane transporter activity
FH977_RS01700	COG1040	competence protein
FH977_RS01725	COG1918	ferrous iron import across plasma membrane
FH977_RS01730	COG2183	response to ionizing radiation
FH977_RS01735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FH977_RS01760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FH977_RS01765	COG1011	Hydrolase
FH977_RS01775	COG0494	nUDIX hydrolase
FH977_RS01780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FH977_RS01805	COG4796	Type ii and iii secretion system protein
FH977_RS01820	COG3266	domain, Protein
FH977_RS01825	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FH977_RS01830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FH977_RS01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FH977_RS01860	COG0402	S-adenosylhomocysteine deaminase activity
FH977_RS01865	COG0738	Major facilitator superfamily
FH977_RS01890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH977_RS01895	COG1289	transmembrane transporter activity
FH977_RS01905	COG1765	OsmC-like protein
FH977_RS01910	COG3954	Phosphoribulokinase
FH977_RS01920	COG0429	hydrolase of the alpha beta-hydrolase fold
FH977_RS01930	COG0488	(ABC) transporter
FH977_RS01945	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FH977_RS01950	COG1047	Peptidyl-prolyl cis-trans
FH977_RS01960	COG0545	Peptidyl-prolyl cis-trans isomerase
FH977_RS01965	COG2964	Protein conserved in bacteria
FH977_RS02020	COG0051	transcription antitermination factor activity, RNA binding
FH977_RS02045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FH977_RS02060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FH977_RS02125	COG0201	protein transport
FH977_RS02150	COG0202	RNA polymerase activity
FH977_RS02165	COG0789	Transcriptional regulator
FH977_RS02170	COG3036	rescue of stalled ribosome
FH977_RS02200	COG0758	DNA mediated transformation
FH977_RS02210	COG0551	DNA topoisomerase type I activity
FH977_RS02230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FH977_RS02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH977_RS02270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS02275	COG1309	transcriptional regulator
FH977_RS02305	COG3924	membrane
FH977_RS02310	COG0439	Biotin carboxylase
FH977_RS02315	COG0511	ligase activity, forming carbon-carbon bonds
FH977_RS02340	COG2199	diguanylate cyclase activity
FH977_RS02340	COG2200	EAL domain
FH977_RS02345	COG1077	Cell shape determining protein MreB Mrl
FH977_RS02350	COG1792	Involved in formation and maintenance of cell shape
FH977_RS02355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FH977_RS02365	COG1530	ribonuclease E activity
FH977_RS02370	COG3164	Protein of unknown function
FH977_RS02375	COG0312	modulator of DNA gyrase
FH977_RS02380	COG0583	DNA-binding transcription factor activity
FH977_RS02395	COG1289	transmembrane transporter activity
FH977_RS02400	COG2732	(Barnase) inhibitor
FH977_RS02425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH977_RS02430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH977_RS02435	COG3105	Protein conserved in bacteria
FH977_RS02440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FH977_RS02465	COG0625	glutathione transferase activity
FH977_RS02470	COG2969	positive regulation of protein catabolic process
FH977_RS02480	COG0493	'glutamate synthase
FH977_RS02485	COG0070	glutamate synthase
FH977_RS02485	COG0069	glutamate synthase activity
FH977_RS02485	COG0067	glutamate synthase
FH977_RS02490	COG1242	4 iron, 4 sulfur cluster binding
FH977_RS02495	COG2271	Major facilitator Superfamily
FH977_RS02500	COG1063	alcohol dehydrogenase
FH977_RS02505	COG1312	Catalyzes the dehydration of D-mannonate
FH977_RS02510	COG2198	Histidine kinase
FH977_RS02510	COG0784	Response regulator, receiver
FH977_RS02510	COG5002	protein histidine kinase activity
FH977_RS02515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FH977_RS02520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH977_RS02525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS02535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS02540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FH977_RS02545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FH977_RS02550	COG1137	ATPase activity
FH977_RS02555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FH977_RS02560	COG3117	lipopolysaccharide transmembrane transporter activity
FH977_RS02565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FH977_RS02575	COG0530	calcium, potassium:sodium antiporter activity
FH977_RS02585	COG1127	ABC transporter
FH977_RS02590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FH977_RS02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FH977_RS02600	COG2854	intermembrane phospholipid transfer
FH977_RS02605	COG3113	response to antibiotic
FH977_RS02610	COG5007	Belongs to the BolA IbaG family
FH977_RS02620	COG3423	Transcriptional regulator
FH977_RS02625	COG0142	geranyltranstransferase activity
FH977_RS02640	COG0697	spore germination
FH977_RS02650	COG2027	D-alanyl-D-alanine carboxypeptidase
FH977_RS02660	COG1534	Rna-binding protein
FH977_RS02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH977_RS02675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FH977_RS02685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FH977_RS02725	COG0195	Participates in both transcription termination and antitermination
FH977_RS02770	COG0814	amino acid
FH977_RS02795	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FH977_RS02840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH977_RS02845	COG0826	peptidase U32
FH977_RS02850	COG0826	peptidase U32
FH977_RS02855	COG3154	lipid carrier protein
FH977_RS02860	COG3153	acetyltransferase
FH977_RS02875	COG0693	protein deglycase activity
FH977_RS02880	COG0702	epimerase
FH977_RS02885	COG0701	Predicted permease
FH977_RS02890	COG2823	Periplasmic or secreted lipoprotein
FH977_RS02910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FH977_RS02925	COG1063	alcohol dehydrogenase
FH977_RS02930	COG3775	system Galactitol-specific IIC component
FH977_RS02935	COG3414	Phosphotransferase system galactitol-specific IIB component
FH977_RS02940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS02950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS02950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS02955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH977_RS02955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH977_RS02955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS02960	COG1105	Belongs to the carbohydrate kinase PfkB family
FH977_RS02970	COG1349	DNA-binding transcription factor activity
FH977_RS02975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH977_RS02980	COG2721	sulfolactate sulfo-lyase activity
FH977_RS02990	COG2271	Major facilitator Superfamily
FH977_RS03000	COG2084	Dehydrogenase
FH977_RS03005	COG1929	Belongs to the glycerate kinase type-1 family
FH977_RS03025	COG1741	Belongs to the pirin family
FH977_RS03030	COG0583	DNA-binding transcription factor activity
FH977_RS03035	COG3152	Membrane
FH977_RS03040	COG0435	Glutathione S-transferase
FH977_RS03045	COG2259	Doxx family
FH977_RS03055	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
FH977_RS03060	COG4575	ribosome binding
FH977_RS03065	COG1422	Protein of unknown function (DUF1090)
FH977_RS03075	COG0586	Pfam SNARE associated Golgi protein
FH977_RS03080	COG2186	Transcriptional regulator
FH977_RS03085	COG2271	Major facilitator Superfamily
FH977_RS03095	COG2721	sulfolactate sulfo-lyase activity
FH977_RS03110	COG0861	Integral membrane protein TerC family
FH977_RS03115	COG0673	inositol 2-dehydrogenase activity
FH977_RS03120	COG1451	nucleotide metabolic process
FH977_RS03140	COG1902	pentaerythritol trinitrate reductase activity
FH977_RS03140	COG0446	pyridine nucleotide-disulphide oxidoreductase
FH977_RS03190	COG1695	Transcriptional regulator
FH977_RS03195	COG2375	cellular response to nickel ion
FH977_RS03210	COG1461	Dihydroxyacetone kinase
FH977_RS03215	COG2376	Dihydroxyacetone kinase
FH977_RS03285	COG3247	response to pH
FH977_RS03295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS03295	COG2198	Histidine kinase
FH977_RS03295	COG2205	protein histidine kinase activity
FH977_RS03295	COG0784	Response regulator, receiver
FH977_RS03300	COG2197	response regulator
FH977_RS03320	COG4974	Belongs to the 'phage' integrase family
FH977_RS03380	COG4695	Portal protein
FH977_RS03535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FH977_RS03540	COG0358	DNA primase activity
FH977_RS03545	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FH977_RS03605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FH977_RS03620	COG4991	sh3 domain protein
FH977_RS03625	COG3025	triphosphatase activity
FH977_RS03645	COG2960	long-chain fatty acid transporting porin activity
FH977_RS03660	COG3384	dioxygenase
FH977_RS03665	COG0754	glutathionylspermidine amidase activity
FH977_RS03680	COG0494	nUDIX hydrolase
FH977_RS03685	COG3151	Protein conserved in bacteria
FH977_RS03690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FH977_RS03695	COG3150	esterase
FH977_RS03705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FH977_RS03710	COG2249	NAD(P)H dehydrogenase (quinone) activity
FH977_RS03715	COG0642	Histidine kinase
FH977_RS03725	COG3111	PFAM Bacterial OB fold (BOF) protein
FH977_RS03730	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FH977_RS03735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FH977_RS03740	COG0204	Acyl-transferase
FH977_RS03745	COG2132	Multicopper oxidase
FH977_RS03750	COG1032	radical SAM domain protein
FH977_RS03760	COG0656	L-ascorbic acid biosynthetic process
FH977_RS03765	COG1979	alcohol dehydrogenase
FH977_RS03770	COG2207	Transcriptional regulator
FH977_RS03775	COG0586	Pfam SNARE associated Golgi protein
FH977_RS03780	COG0626	cystathionine gamma-synthase activity
FH977_RS03790	COG0848	biopolymer transport protein
FH977_RS03795	COG2211	Major facilitator Superfamily
FH977_RS03820	COG0625	glutathione transferase activity
FH977_RS03830	COG0754	glutathionylspermidine amidase activity
FH977_RS03860	COG0626	cystathionine gamma-synthase activity
FH977_RS03875	COG1811	Na channel or pump
FH977_RS03885	COG1982	Orn Lys Arg decarboxylase major
FH977_RS03890	COG2211	Major facilitator Superfamily
FH977_RS03905	COG1194	a g-specific adenine glycosylase
FH977_RS03915	COG3171	Protein conserved in bacteria
FH977_RS03925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FH977_RS03940	COG0762	integral membrane protein
FH977_RS03945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FH977_RS03950	COG2805	Type II/IV secretion system protein
FH977_RS03970	COG0189	ligase activity
FH977_RS03975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FH977_RS03980	COG2356	endonuclease I
FH977_RS03990	COG2814	Major facilitator Superfamily
FH977_RS04025	COG2146	nitrite reductase [NAD(P)H] activity
FH977_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS04045	COG1414	Transcriptional regulator
FH977_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS04080	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FH977_RS04100	COG0501	Belongs to the peptidase M48B family
FH977_RS04105	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FH977_RS04120	COG0191	fructose-bisphosphate aldolase activity
FH977_RS04125	COG0668	transmembrane transport
FH977_RS04135	COG2968	Membrane
FH977_RS04150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH977_RS04155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FH977_RS04175	COG0006	proline dipeptidase activity
FH977_RS04180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH977_RS04185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH977_RS04205	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS04215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FH977_RS04235	COG2723	6-phospho-beta-galactosidase activity
FH977_RS04240	COG1737	Transcriptional regulator
FH977_RS04250	COG1272	protein, Hemolysin III
FH977_RS04260	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FH977_RS04270	COG0716	FMN binding
FH977_RS04275	COG4974	Belongs to the 'phage' integrase family
FH977_RS04285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FH977_RS04305	COG4942	peptidase
FH977_RS04315	COG2814	Major facilitator Superfamily
FH977_RS04330	COG0667	Aldo Keto reductase
FH977_RS04375	COG1393	Belongs to the ArsC family
FH977_RS04395	COG1538	Outer membrane efflux protein
FH977_RS04400	COG1289	transmembrane transporter activity
FH977_RS04415	COG3592	Divergent 4Fe-4S mono-cluster
FH977_RS04420	COG2388	GCN5-related N-acetyl-transferase
FH977_RS04430	COG3539	Fimbrial protein
FH977_RS04435	COG3539	Fimbrial protein
FH977_RS04440	COG3539	Fimbrial protein
FH977_RS04445	COG3188	usher protein
FH977_RS04450	COG3121	Chaperone
FH977_RS04455	COG3539	Fimbrial protein
FH977_RS04465	COG4974	Belongs to the 'phage' integrase family
FH977_RS04470	COG0582	viral genome integration into host DNA
FH977_RS04480	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FH977_RS04485	COG1846	Transcriptional regulator
FH977_RS04490	COG0697	spore germination
FH977_RS04540	COG0667	Aldo Keto reductase
FH977_RS04545	COG0814	amino acid
FH977_RS04560	COG0183	Belongs to the thiolase family
FH977_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS04580	COG2814	Major facilitator Superfamily
FH977_RS04610	COG3842	ATPase activity
FH977_RS04615	COG0395	ABC-type sugar transport system, permease component
FH977_RS04620	COG1175	transmembrane transport
FH977_RS04625	COG1917	Cupin 2, conserved barrel domain protein
FH977_RS04630	COG1794	racemase activity, acting on amino acids and derivatives
FH977_RS04635	COG0583	DNA-binding transcription factor activity
FH977_RS04645	COG1609	Transcriptional regulator
FH977_RS04650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS04655	COG2723	6-phospho-beta-galactosidase activity
FH977_RS04660	COG2186	Transcriptional regulator
FH977_RS04670	COG1609	Transcriptional regulator
FH977_RS04685	COG0667	Aldo Keto reductase
FH977_RS04695	COG0861	Integral membrane protein TerC family
FH977_RS04730	COG2165	general secretion pathway protein
FH977_RS04735	COG4795	General secretion pathway protein
FH977_RS04745	COG4967	type IV pilus modification protein PilV
FH977_RS04750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FH977_RS04755	COG1025	Belongs to the peptidase M16 family
FH977_RS04760	COG1074	ATP-dependent DNA helicase activity
FH977_RS04765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FH977_RS04780	COG0860	N-Acetylmuramoyl-L-alanine amidase
FH977_RS04785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FH977_RS04815	COG4656	Part of a membrane complex involved in electron transport
FH977_RS04820	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS04820	COG1454	alcohol dehydrogenase
FH977_RS04850	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FH977_RS05015	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FH977_RS05020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FH977_RS05025	COG2166	iron-sulfur cluster assembly
FH977_RS05030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FH977_RS05040	COG0583	DNA-binding transcription factor activity
FH977_RS05045	COG2363	Small membrane protein
FH977_RS05055	COG1349	DNA-binding transcription factor activity
FH977_RS05075	COG0738	Major facilitator superfamily
FH977_RS05080	COG0235	Class ii aldolase
FH977_RS05085	COG1454	alcohol dehydrogenase
FH977_RS05100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH977_RS05115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FH977_RS05120	COG2011	ABC-type metal ion transport system permease component
FH977_RS05125	COG1464	Belongs to the NlpA lipoprotein family
FH977_RS05135	COG0477	Major facilitator Superfamily
FH977_RS05145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH977_RS05150	COG1760	l-serine dehydratase
FH977_RS05155	COG0814	amino acid
FH977_RS05160	COG1611	Belongs to the LOG family
FH977_RS05175	COG3098	single-species biofilm formation
FH977_RS05180	COG0564	pseudouridine synthase activity
FH977_RS05185	COG0716	FMN binding
FH977_RS05190	COG2271	Major facilitator Superfamily
FH977_RS05195	COG4948	Mandelate Racemase Muconate Lactonizing
FH977_RS05200	COG4948	Mandelate Racemase Muconate Lactonizing
FH977_RS05215	COG4999	Histidine kinase
FH977_RS05215	COG3437	response regulator, receiver
FH977_RS05215	COG2205	protein histidine kinase activity
FH977_RS05215	COG3850	Histidine kinase
FH977_RS05225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FH977_RS05230	COG3956	TIGRFAM MazG family protein
FH977_RS05250	COG0602	queuosine metabolic process
FH977_RS05255	COG0720	synthase
FH977_RS05275	COG2234	aminopeptidase activity
FH977_RS05335	COG1388	LysM domain
FH977_RS05335	COG4942	peptidase
FH977_RS05340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FH977_RS05365	COG0163	prenyltransferase activity
FH977_RS05370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FH977_RS05415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS05420	COG4558	Periplasmic binding protein
FH977_RS05425	COG3720	iron ion transport
FH977_RS05445	COG0679	Auxin Efflux Carrier
FH977_RS05460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH977_RS05465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH977_RS05470	COG1121	(ABC) transporter
FH977_RS05475	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH977_RS05480	COG1609	Transcriptional regulator
FH977_RS05485	COG1940	carbohydrate kinase activity
FH977_RS05490	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH977_RS05495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS05500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS05505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS05515	COG4580	involved in the transport of maltose and maltodextrins
FH977_RS05525	COG2723	6-phospho-beta-galactosidase activity
FH977_RS05535	COG0309	Hydrogenase expression formation protein (HypE)
FH977_RS05540	COG0409	Hydrogenase expression formation protein
FH977_RS05545	COG0298	carbon dioxide binding
FH977_RS05550	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FH977_RS05570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH977_RS05575	COG0651	ATP synthesis coupled electron transport
FH977_RS05580	COG0650	Formate hydrogenlyase subunit 4
FH977_RS05585	COG3261	NADH dehydrogenase
FH977_RS05585	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FH977_RS05590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH977_RS05595	COG3260	NADH ubiquinone oxidoreductase 20
FH977_RS05605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FH977_RS05615	COG2723	6-phospho-beta-galactosidase activity
FH977_RS05620	COG1263	PTS System
FH977_RS05620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS05625	COG1609	Transcriptional regulator
FH977_RS05630	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH977_RS05635	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FH977_RS05640	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FH977_RS05670	COG1349	DNA-binding transcription factor activity
FH977_RS05675	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS05680	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS05690	COG3732	PTS system glucitol sorbitol-specific
FH977_RS05695	COG3730	PTS system glucitol sorbitol-specific
FH977_RS05700	COG2951	lytic endotransglycosylase activity
FH977_RS05715	COG1121	(ABC) transporter
FH977_RS05720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH977_RS05725	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH977_RS05730	COG1546	Belongs to the CinA family
FH977_RS05755	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FH977_RS05785	COG2823	Periplasmic or secreted lipoprotein
FH977_RS05790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH977_RS05795	COG1238	metal cluster binding
FH977_RS05815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FH977_RS05820	COG2814	Major facilitator Superfamily
FH977_RS05825	COG1566	PFAM secretion protein HlyD family protein
FH977_RS05830	COG1846	Transcriptional regulator
FH977_RS05840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FH977_RS05850	COG4176	ABC-type proline glycine betaine transport system permease component
FH977_RS05865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FH977_RS05875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FH977_RS05880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH977_RS05885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH977_RS05890	COG4575	ribosome binding
FH977_RS05915	COG2916	Histone family protein nucleoid-structuring protein H-NS
FH977_RS05930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FH977_RS05935	COG0640	Transcriptional regulator
FH977_RS05945	COG0583	DNA-binding transcription factor activity
FH977_RS05950	COG3284	Transcriptional regulator
FH977_RS05960	COG3539	Fimbrial protein
FH977_RS05965	COG3121	Chaperone
FH977_RS06010	COG3539	Fimbrial protein
FH977_RS06015	COG2197	response regulator
FH977_RS06045	COG0235	Class ii aldolase
FH977_RS06050	COG1126	abc transporter atp-binding protein
FH977_RS06055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS06095	COG3708	Transcriptional regulator
FH977_RS06095	COG2207	Transcriptional regulator
FH977_RS06130	COG0582	viral genome integration into host DNA
FH977_RS06200	COG1484	DNA-dependent DNA replication
FH977_RS06210	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
FH977_RS06220	COG0484	heat shock protein binding
FH977_RS06235	COG3772	lysozyme
FH977_RS06280	COG1802	Transcriptional regulator
FH977_RS06280	COG4626	Terminase
FH977_RS06285	COG4695	Portal protein
FH977_RS06290	COG0740	serine-type endopeptidase activity
FH977_RS06425	COG2867	negative regulation of translational initiation
FH977_RS06440	COG0497	DNA recombination
FH977_RS06455	COG4536	flavin adenine dinucleotide binding
FH977_RS06460	COG4137	Cytochrome C assembly protein
FH977_RS06465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FH977_RS06500	COG2885	chlorophyll binding
FH977_RS06505	COG2199	diguanylate cyclase activity
FH977_RS06515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FH977_RS06520	COG0287	Prephenate dehydrogenase
FH977_RS06520	COG1605	Chorismate mutase
FH977_RS06530	COG1605	Chorismate mutase
FH977_RS06530	COG0077	Prephenate dehydratase
FH977_RS06540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FH977_RS06545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH977_RS06560	COG0542	response to heat
FH977_RS06585	COG0477	Major facilitator Superfamily
FH977_RS06590	COG5544	Lipoprotein
FH977_RS06595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FH977_RS06605	COG3148	PFAM DTW domain containing protein
FH977_RS06610	COG3118	belongs to the thioredoxin family
FH977_RS06615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FH977_RS06630	COG0513	Belongs to the DEAD box helicase family
FH977_RS06640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FH977_RS06655	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FH977_RS06660	COG3026	antisigma factor binding
FH977_RS06665	COG3086	response to oxidative stress
FH977_RS06675	COG0681	Belongs to the peptidase S26 family
FH977_RS06695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FH977_RS06705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH977_RS06710	COG1737	Transcriptional regulator
FH977_RS06715	COG0560	Phosphoserine phosphatase
FH977_RS06730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FH977_RS06730	COG0047	phosphoribosylformylglycinamidine synthase activity
FH977_RS06740	COG2205	protein histidine kinase activity
FH977_RS06750	COG2204	response regulator
FH977_RS06755	COG0347	Belongs to the P(II) protein family
FH977_RS06760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH977_RS06760	COG1017	nitric oxide dioxygenase activity
FH977_RS06770	COG2259	Doxx family
FH977_RS06775	COG1940	carbohydrate kinase activity
FH977_RS06780	COG0457	Tetratricopeptide repeat
FH977_RS06785	COG0477	Major facilitator Superfamily
FH977_RS06785	COG2814	Major facilitator Superfamily
FH977_RS06790	COG2017	converts alpha-aldose to the beta-anomer
FH977_RS06795	COG2814	Major facilitator Superfamily
FH977_RS06800	COG3711	transcriptional antiterminator
FH977_RS06805	COG3683	transport system, periplasmic component
FH977_RS06810	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FH977_RS06840	COG0822	iron-sulfur transferase activity
FH977_RS06860	COG0633	Ferredoxin
FH977_RS06865	COG2975	iron-sulfur cluster assembly
FH977_RS06885	COG2897	thiosulfate sulfurtransferase activity
FH977_RS06890	COG2373	Large extracellular alpha-helical protein
FH977_RS06895	COG4953	penicillin-binding protein 1C
FH977_RS06930	COG2976	Protein conserved in bacteria
FH977_RS06950	COG1645	bacterial-type flagellum-dependent swarming motility
FH977_RS06960	COG0517	IMP dehydrogenase activity
FH977_RS06960	COG0516	GMP reductase activity
FH977_RS07025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FH977_RS07050	COG2233	PERMEase
FH977_RS07065	COG1393	Belongs to the ArsC family
FH977_RS07070	COG4783	chaperone-mediated protein folding
FH977_RS07075	COG0628	permease
FH977_RS07080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FH977_RS07085	COG2716	regulation of RNA biosynthetic process
FH977_RS07095	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FH977_RS07105	COG2321	neutral zinc metallopeptidase
FH977_RS07115	COG0400	carboxylic ester hydrolase activity
FH977_RS07130	COG1393	Belongs to the ArsC family
FH977_RS07140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH977_RS07160	COG5342	invasion associated locus B
FH977_RS07170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH977_RS07180	COG4810	utilization protein
FH977_RS07270	COG0860	N-Acetylmuramoyl-L-alanine amidase
FH977_RS07290	COG2837	iron assimilation
FH977_RS07300	COG4150	thiosulfate binding
FH977_RS07305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FH977_RS07310	COG4208	sulfate ABC transporter
FH977_RS07315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FH977_RS07325	COG4319	ketosteroid isomerase
FH977_RS07360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FH977_RS07380	COG3530	Putative quorum-sensing-regulated virulence factor
FH977_RS07385	COG0385	Bile acid
FH977_RS07390	COG0583	DNA-binding transcription factor activity
FH977_RS07425	COG3415	Transposase
FH977_RS07430	COG3415	Transposase
FH977_RS07445	COG2199	diguanylate cyclase activity
FH977_RS07445	COG2200	EAL domain
FH977_RS07450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FH977_RS07465	COG0667	Aldo Keto reductase
FH977_RS07470	COG3961	Belongs to the TPP enzyme family
FH977_RS07485	COG3279	Response regulator of the LytR AlgR family
FH977_RS07490	COG3275	phosphorelay sensor kinase activity
FH977_RS07500	COG0436	Aminotransferase
FH977_RS07510	COG2807	transmembrane transport
FH977_RS07515	COG0590	tRNA wobble adenosine to inosine editing
FH977_RS07520	COG0583	DNA-binding transcription factor activity
FH977_RS07540	COG2116	formate transmembrane transporter activity
FH977_RS07545	COG2853	Lipoprotein
FH977_RS07555	COG3691	Protein conserved in bacteria
FH977_RS07570	COG2062	phosphohistidine phosphatase, SixA
FH977_RS07595	COG0730	response to heat
FH977_RS07600	COG3101	peptidyl-lysine hydroxylation
FH977_RS07615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH977_RS07635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FH977_RS07645	COG0586	Pfam SNARE associated Golgi protein
FH977_RS07655	COG0285	dihydrofolate synthase activity
FH977_RS07660	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FH977_RS07665	COG1286	toxin biosynthetic process
FH977_RS07670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FH977_RS07675	COG3829	transcription factor binding
FH977_RS07685	COG0531	amino acid
FH977_RS07690	COG3457	Alanine racemase
FH977_RS07695	COG0833	amino acid
FH977_RS07700	COG0163	prenyltransferase activity
FH977_RS07720	COG4160	amino acid transport
FH977_RS07725	COG4598	ABC transporter
FH977_RS07735	COG1090	epimerase
FH977_RS07740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FH977_RS07745	COG0625	glutathione transferase activity
FH977_RS07750	COG0625	glutathione transferase activity
FH977_RS07755	COG0622	Phosphoesterase
FH977_RS07760	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FH977_RS07765	COG0280	phosphate acetyltransferase
FH977_RS07765	COG0857	belongs to the CobB CobQ family
FH977_RS07785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH977_RS07790	COG0471	metal ion transport
FH977_RS07790	COG0490	domain, Protein
FH977_RS07800	COG0436	Aminotransferase
FH977_RS07805	COG0583	DNA-binding transcription factor activity
FH977_RS07855	COG0839	Belongs to the complex I subunit 6 family
FH977_RS07865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FH977_RS07885	COG2153	protein acetylation
FH977_RS07890	COG1169	isochorismate synthase
FH977_RS07915	COG0318	PFAM AMP-dependent synthetase and ligase
FH977_RS07925	COG5464	transposase or invertase
FH977_RS07940	COG1414	Transcriptional regulator
FH977_RS07950	COG2271	Major facilitator Superfamily
FH977_RS07960	COG0247	lactate metabolic process
FH977_RS07970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FH977_RS07975	COG2271	Major facilitator Superfamily
FH977_RS07980	COG0584	glycerophosphoryl diester phosphodiesterase
FH977_RS07985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH977_RS08010	COG2205	protein histidine kinase activity
FH977_RS08010	COG0784	Response regulator, receiver
FH977_RS08020	COG0642	Histidine kinase
FH977_RS08020	COG2198	Histidine kinase
FH977_RS08035	COG2169	Transcriptional regulator
FH977_RS08035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FH977_RS08040	COG3145	DNA-N1-methyladenine dioxygenase activity
FH977_RS08045	COG4615	Cyclic peptide transporter
FH977_RS08050	COG2239	Acts as a magnesium transporter
FH977_RS08070	COG0628	permease
FH977_RS08095	COG1349	DNA-binding transcription factor activity
FH977_RS08100	COG0494	nUDIX hydrolase
FH977_RS08120	COG1061	Type III restriction enzyme res subunit
FH977_RS08125	COG1187	pseudouridine synthase activity
FH977_RS08130	COG2814	Major facilitator Superfamily
FH977_RS08140	COG4172	Belongs to the ABC transporter superfamily
FH977_RS08145	COG4239	(ABC) transporter, permease
FH977_RS08150	COG4174	ABC transporter (Permease)
FH977_RS08155	COG4166	transmembrane transport
FH977_RS08160	COG2200	EAL domain
FH977_RS08165	COG0791	NLP P60 protein
FH977_RS08170	COG0671	phosphoesterase, PA-phosphatase related
FH977_RS08180	COG0246	Mannitol dehydrogenase
FH977_RS08185	COG1312	Catalyzes the dehydration of D-mannonate
FH977_RS08205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS08205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS08210	COG1105	Belongs to the carbohydrate kinase PfkB family
FH977_RS08215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH977_RS08215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH977_RS08215	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FH977_RS08225	COG2855	membrane
FH977_RS08230	COG0583	DNA-binding transcription factor activity
FH977_RS08235	COG0833	amino acid
FH977_RS08240	COG4771	TonB-dependent receptor
FH977_RS08255	COG2311	Membrane
FH977_RS08270	COG1129	ABC transporter
FH977_RS08280	COG2949	membrane
FH977_RS08290	COG1346	cytolysis
FH977_RS08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FH977_RS08305	COG3659	wide pore channel activity
FH977_RS08320	COG2723	6-phospho-beta-galactosidase activity
FH977_RS08325	COG1538	Outer membrane efflux protein
FH977_RS08330	COG0586	Pfam SNARE associated Golgi protein
FH977_RS08340	COG1686	Belongs to the peptidase S11 family
FH977_RS08355	COG0277	FAD linked oxidase domain protein
FH977_RS08360	COG1472	Belongs to the glycosyl hydrolase 3 family
FH977_RS08365	COG1732	Glycine betaine
FH977_RS08375	COG1125	glycine betaine transport
FH977_RS08380	COG1174	glycine betaine transport
FH977_RS08400	COG4807	Protein conserved in bacteria
FH977_RS08420	COG5455	response to cobalt ion
FH977_RS08425	COG0583	DNA-binding transcription factor activity
FH977_RS08430	COG2252	PERMEase
FH977_RS08440	COG0583	DNA-binding transcription factor activity
FH977_RS08455	COG0351	phosphomethylpyrimidine kinase
FH977_RS08460	COG1830	Aldolase
FH977_RS08505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH977_RS08510	COG4948	Mandelate Racemase Muconate Lactonizing
FH977_RS08515	COG0747	negative chemotaxis
FH977_RS08520	COG0601	transmembrane transport
FH977_RS08525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH977_RS08530	COG0444	Belongs to the ABC transporter superfamily
FH977_RS08535	COG4608	Belongs to the ABC transporter superfamily
FH977_RS08545	COG0826	peptidase U32
FH977_RS08550	COG0745	RESPONSE REGULATOR receiver
FH977_RS08555	COG2205	protein histidine kinase activity
FH977_RS08580	COG1301	dicarboxylic acid transport
FH977_RS08600	COG5002	protein histidine kinase activity
FH977_RS08605	COG0443	Heat shock 70 kDa protein
FH977_RS08610	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FH977_RS08625	COG2982	Protein involved in outer membrane biogenesis
FH977_RS08630	COG1253	flavin adenine dinucleotide binding
FH977_RS08680	COG0463	Glycosyl transferase, family 2
FH977_RS08705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FH977_RS08760	COG0438	transferase activity, transferring glycosyl groups
FH977_RS08765	COG1215	transferase activity, transferring glycosyl groups
FH977_RS08785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FH977_RS08815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH977_RS08820	COG0583	DNA-binding transcription factor activity
FH977_RS08830	COG0531	amino acid
FH977_RS08835	COG0640	Transcriptional regulator
FH977_RS08840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FH977_RS08845	COG2925	Exonuclease
FH977_RS08860	COG1289	transmembrane transporter activity
FH977_RS08880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FH977_RS08890	COG1942	4-Oxalocrotonate Tautomerase
FH977_RS08895	COG0583	DNA-binding transcription factor activity
FH977_RS08900	COG0095	Lipoate-protein ligase
FH977_RS08905	COG0477	Major facilitator Superfamily
FH977_RS08920	COG3300	MHYT domain
FH977_RS08920	COG5001	Diguanylate cyclase
FH977_RS08930	COG3615	Tellurite resistance protein tehB
FH977_RS08955	COG3706	GGDEF domain
FH977_RS08995	COG2197	response regulator
FH977_RS09015	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH977_RS09020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH977_RS09025	COG1960	acyl-CoA dehydrogenase activity
FH977_RS09055	COG0154	amidase activity
FH977_RS09080	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FH977_RS09150	COG3504	Conjugal transfer protein
FH977_RS09230	COG4771	TonB-dependent receptor
FH977_RS09235	COG1021	2,3-dihydroxybenzoate-AMP ligase
FH977_RS09270	COG1132	(ABC) transporter
FH977_RS09275	COG2814	Major facilitator Superfamily
FH977_RS09280	COG1169	isochorismate synthase
FH977_RS09285	COG0582	viral genome integration into host DNA
FH977_RS09305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS09310	COG0735	belongs to the Fur family
FH977_RS09320	COG0523	cobalamin synthesis protein
FH977_RS09380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH977_RS09385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH977_RS09390	COG1121	(ABC) transporter
FH977_RS09395	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH977_RS09400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FH977_RS09440	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH977_RS09445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH977_RS09450	COG1121	(ABC) transporter
FH977_RS09460	COG0582	viral genome integration into host DNA
FH977_RS09470	COG0534	Mate efflux family protein
FH977_RS09480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FH977_RS09500	COG0604	alcohol dehydrogenase
FH977_RS09505	COG1309	transcriptional regulator
FH977_RS09510	COG0025	NhaP-type Na H and K H
FH977_RS09560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FH977_RS09580	COG0270	DNA (cytosine-5-)-methyltransferase activity
FH977_RS09585	COG3727	T/G mismatch-specific endonuclease activity
FH977_RS09590	COG0697	spore germination
FH977_RS09595	COG2354	Protein conserved in bacteria
FH977_RS09630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS09640	COG0765	amino acid transport
FH977_RS09645	COG1126	abc transporter atp-binding protein
FH977_RS09650	COG2197	response regulator
FH977_RS09660	COG2197	response regulator
FH977_RS09695	COG3012	SEC-C Motif Domain Protein
FH977_RS09695	COG3318	Belongs to the UPF0149 family
FH977_RS09710	COG1528	Iron-storage protein
FH977_RS09725	COG0477	Major facilitator Superfamily
FH977_RS09735	COG2211	Major facilitator Superfamily
FH977_RS09745	COG1528	Iron-storage protein
FH977_RS09755	COG1879	ABC-type sugar transport system periplasmic component
FH977_RS09765	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS09790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FH977_RS09800	COG3102	Protein conserved in bacteria
FH977_RS09820	COG3788	relative of glutathione S-transferase, MAPEG superfamily
FH977_RS09825	COG1801	Protein of unknown function DUF72
FH977_RS09830	COG1335	isochorismatase
FH977_RS09840	COG0494	nUDIX hydrolase
FH977_RS09865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH977_RS09875	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FH977_RS09880	COG0739	heme binding
FH977_RS09885	COG1560	Kdo2-lipid A biosynthetic process
FH977_RS09895	COG1737	Transcriptional regulator
FH977_RS09910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FH977_RS09915	COG0129	dihydroxy-acid dehydratase activity
FH977_RS09920	COG0800	Aldolase
FH977_RS09930	COG3141	response to X-ray
FH977_RS09935	COG2979	Protein of unknown function (DUF533)
FH977_RS09955	COG2372	response to copper ion
FH977_RS09960	COG1276	copper resistance
FH977_RS09980	COG2990	Protein conserved in bacteria
FH977_RS10005	COG3008	intermembrane lipid transfer
FH977_RS10015	COG1956	GAF domain-containing protein
FH977_RS10040	COG1414	Transcriptional regulator
FH977_RS10080	COG0768	penicillin binding
FH977_RS10085	COG2226	methyltransferase
FH977_RS10100	COG3716	PTS system mannose fructose sorbose family IID component
FH977_RS10105	COG3715	PTS system
FH977_RS10110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS10110	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS10115	COG1253	flavin adenine dinucleotide binding
FH977_RS10120	COG2200	EAL domain
FH977_RS10125	COG1760	l-serine dehydratase
FH977_RS10145	COG0251	oxidation-reduction process
FH977_RS10155	COG1214	PFAM Peptidase M22, glycoprotease
FH977_RS10160	COG3065	identical protein binding
FH977_RS10170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FH977_RS10180	COG2894	cell division
FH977_RS10195	COG0179	Fumarylacetoacetate (FAA) hydrolase
FH977_RS10225	COG2719	SpoVR family
FH977_RS10245	COG1619	proteins homologs of microcin C7 resistance protein MccF
FH977_RS10255	COG4774	siderophore transport
FH977_RS10270	COG2308	Evidence 4 Homologs of previously reported genes of
FH977_RS10310	COG0583	DNA-binding transcription factor activity
FH977_RS10315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FH977_RS10330	COG1882	Formate acetyltransferase
FH977_RS10360	COG0583	DNA-binding transcription factor activity
FH977_RS10390	COG0583	DNA-binding transcription factor activity
FH977_RS10405	COG3122	Protein conserved in bacteria
FH977_RS10435	COG2885	chlorophyll binding
FH977_RS10525	COG0012	GTP binding
FH977_RS10545	COG0659	secondary active sulfate transmembrane transporter activity
FH977_RS10575	COG2890	protein-(glutamine-N5) methyltransferase activity
FH977_RS10595	COG0387	Pfam Sodium calcium exchanger
FH977_RS10600	COG4572	Cation transport regulator
FH977_RS10605	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FH977_RS10615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FH977_RS10620	COG3707	response regulator
FH977_RS10625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH977_RS10635	COG1116	anion transmembrane transporter activity
FH977_RS10640	COG2146	nitrite reductase [NAD(P)H] activity
FH977_RS10640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FH977_RS10645	COG0243	molybdopterin cofactor binding
FH977_RS10650	COG4932	domain protein
FH977_RS10655	COG2197	response regulator
FH977_RS10660	COG3850	Histidine kinase
FH977_RS10665	COG2223	nitrite transmembrane transporter activity
FH977_RS10675	COG1140	nitrate reductase beta subunit
FH977_RS10680	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FH977_RS10685	COG2181	nitrate reductase activity
FH977_RS10695	COG1522	sequence-specific DNA binding
FH977_RS10725	COG0788	formyltetrahydrofolate deformylase activity
FH977_RS10735	COG1752	Esterase of the alpha-beta hydrolase superfamily
FH977_RS10740	COG0745	RESPONSE REGULATOR receiver
FH977_RS10745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FH977_RS10750	COG2916	Histone family protein nucleoid-structuring protein H-NS
FH977_RS10755	COG1435	thymidine kinase activity
FH977_RS10760	COG1454	alcohol dehydrogenase
FH977_RS10760	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS10770	COG2095	MarC family integral membrane protein
FH977_RS10775	COG4166	transmembrane transport
FH977_RS10780	COG0601	transmembrane transport
FH977_RS10785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH977_RS10790	COG0444	Belongs to the ABC transporter superfamily
FH977_RS10800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH977_RS10820	COG2353	YceI-like domain
FH977_RS10830	COG2350	Protein conserved in bacteria
FH977_RS10885	COG3001	Fructosamine kinase
FH977_RS10895	COG1105	Belongs to the carbohydrate kinase PfkB family
FH977_RS10900	COG3137	Salt-induced outer membrane protein
FH977_RS10985	COG0386	Belongs to the glutathione peroxidase family
FH977_RS10995	COG0791	NLP P60 protein
FH977_RS11005	COG4256	Hemin uptake protein
FH977_RS11010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FH977_RS11020	COG0574	Belongs to the PEP-utilizing enzyme family
FH977_RS11020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FH977_RS11030	COG0628	permease
FH977_RS11040	COG2050	protein possibly involved in aromatic compounds catabolism
FH977_RS11045	COG2261	transglycosylase associated protein
FH977_RS11075	COG1120	ATPase activity
FH977_RS11080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS11090	COG0583	DNA-binding transcription factor activity
FH977_RS11115	COG1304	FMN binding
FH977_RS11120	COG1309	transcriptional regulator
FH977_RS11135	COG0316	Belongs to the HesB IscA family
FH977_RS11140	COG0719	Fe-S assembly protein
FH977_RS11145	COG0396	ATPase activity
FH977_RS11150	COG0719	Fe-S assembly protein
FH977_RS11165	COG1376	ErfK ybiS ycfS ynhG family protein
FH977_RS11190	COG1309	transcriptional regulator
FH977_RS11195	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FH977_RS11195	COG1082	Xylose isomerase domain protein TIM barrel
FH977_RS11200	COG2271	Major facilitator Superfamily
FH977_RS11205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FH977_RS11215	COG1120	ATPase activity
FH977_RS11220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS11225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH977_RS11230	COG1414	Transcriptional regulator
FH977_RS11265	COG2814	Major facilitator Superfamily
FH977_RS11285	COG0583	DNA-binding transcription factor activity
FH977_RS11290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH977_RS11310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH977_RS11315	COG1116	anion transmembrane transporter activity
FH977_RS11320	COG4774	siderophore transport
FH977_RS11325	COG1120	ATPase activity
FH977_RS11330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS11335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS11355	COG0765	amino acid transport
FH977_RS11360	COG1126	abc transporter atp-binding protein
FH977_RS11390	COG1473	amidohydrolase
FH977_RS11395	COG3383	formate dehydrogenase (NAD+) activity
FH977_RS11400	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FH977_RS11415	COG1175	transmembrane transport
FH977_RS11445	COG4133	protoheme IX ABC transporter activity
FH977_RS11450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FH977_RS11455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FH977_RS11470	COG1138	Cytochrome C-type biogenesis protein
FH977_RS11475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FH977_RS11480	COG4235	cytochrome complex assembly
FH977_RS11480	COG3088	subunit of a heme lyase
FH977_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS11535	COG2610	gluconate transmembrane transporter activity
FH977_RS11540	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH977_RS11550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FH977_RS11560	COG0583	DNA-binding transcription factor activity
FH977_RS11580	COG0277	FAD linked oxidase domain protein
FH977_RS11585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH977_RS11610	COG0402	S-adenosylhomocysteine deaminase activity
FH977_RS11665	COG4608	Belongs to the ABC transporter superfamily
FH977_RS11670	COG0444	Belongs to the ABC transporter superfamily
FH977_RS11695	COG0346	lactoylglutathione lyase activity
FH977_RS11700	COG1349	DNA-binding transcription factor activity
FH977_RS11790	COG0307	riboflavin synthase, alpha
FH977_RS11795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FH977_RS11800	COG2814	Major facilitator Superfamily
FH977_RS11805	COG0583	DNA-binding transcription factor activity
FH977_RS11820	COG2814	Major facilitator Superfamily
FH977_RS11835	COG0791	NLP P60 protein
FH977_RS11840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FH977_RS11850	COG0346	lactoylglutathione lyase activity
FH977_RS11855	COG1902	pentaerythritol trinitrate reductase activity
FH977_RS11860	COG1309	transcriptional regulator
FH977_RS11865	COG3313	Fe-S protein
FH977_RS11870	COG4989	oxidoreductase activity
FH977_RS11875	COG2032	superoxide dismutase activity
FH977_RS11880	COG1289	transmembrane transporter activity
FH977_RS11885	COG1566	PFAM secretion protein HlyD family protein
FH977_RS11900	COG3706	GGDEF domain
FH977_RS11915	COG3895	Periplasmic Protein
FH977_RS11930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FH977_RS11935	COG0625	glutathione transferase activity
FH977_RS11950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FH977_RS11960	COG4659	FMN binding
FH977_RS11995	COG2723	6-phospho-beta-galactosidase activity
FH977_RS12005	COG0673	inositol 2-dehydrogenase activity
FH977_RS12015	COG2814	Major facilitator Superfamily
FH977_RS12035	COG3038	cytochrome b561
FH977_RS12055	COG0583	DNA-binding transcription factor activity
FH977_RS12060	COG3485	protocatechuate 3,4-dioxygenase
FH977_RS12070	COG5383	Protein conserved in bacteria
FH977_RS12075	COG2272	Belongs to the type-B carboxylesterase lipase family
FH977_RS12095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FH977_RS12100	COG1275	C4-dicarboxylate transporter malic acid transport protein
FH977_RS12105	COG0500	methyltransferase
FH977_RS12120	COG2207	Transcriptional regulator
FH977_RS12120	COG3708	Transcriptional regulator
FH977_RS12130	COG1396	sequence-specific DNA binding
FH977_RS12140	COG0826	peptidase U32
FH977_RS12160	COG1294	oxidase, subunit
FH977_RS12165	COG1271	oxidase subunit
FH977_RS12170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH977_RS12175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FH977_RS12180	COG3842	ATPase activity
FH977_RS12185	COG1176	ABC-type spermidine putrescine transport system, permease component I
FH977_RS12190	COG1177	transmembrane transport
FH977_RS12195	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS12230	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS12235	COG0747	negative chemotaxis
FH977_RS12245	COG3238	Protein conserved in bacteria
FH977_RS12250	COG1247	-acetyltransferase
FH977_RS12260	COG2130	NADP-dependent
FH977_RS12275	COG3691	Protein conserved in bacteria
FH977_RS12280	COG1228	amidohydrolase
FH977_RS12285	COG4772	TonB-dependent receptor
FH977_RS12315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH977_RS12320	COG1473	amidohydrolase
FH977_RS12325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH977_RS12330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS12340	COG0765	amino acid transport
FH977_RS12345	COG1126	abc transporter atp-binding protein
FH977_RS12355	COG0625	glutathione transferase activity
FH977_RS12385	COG2211	Major facilitator Superfamily
FH977_RS12400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FH977_RS12405	COG3842	ATPase activity
FH977_RS12410	COG1840	ABC-type Fe3 transport system, periplasmic component
FH977_RS12415	COG1178	ABC-type Fe3 transport system permease component
FH977_RS12420	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FH977_RS12425	COG2181	nitrate reductase activity
FH977_RS12435	COG1140	nitrate reductase beta subunit
FH977_RS12440	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FH977_RS12460	COG1414	Transcriptional regulator
FH977_RS12465	COG4948	Mandelate Racemase Muconate Lactonizing
FH977_RS12470	COG4829	muconolactone delta-isomerase
FH977_RS12475	COG3485	protocatechuate 3,4-dioxygenase
FH977_RS12485	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FH977_RS12510	COG0437	4 iron, 4 sulfur cluster binding
FH977_RS12515	COG2864	formate dehydrogenase
FH977_RS12530	COG2326	polyphosphate kinase activity
FH977_RS12540	COG2814	Major facilitator Superfamily
FH977_RS12550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH977_RS12560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH977_RS12570	COG0747	negative chemotaxis
FH977_RS12575	COG1064	alcohol dehydrogenase
FH977_RS12590	COG0488	(ABC) transporter
FH977_RS12625	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS12630	COG3729	General stress protein
FH977_RS12650	COG3685	Protein conserved in bacteria
FH977_RS12660	COG0366	Alpha amylase catalytic
FH977_RS12670	COG2323	membrane
FH977_RS12680	COG3111	PFAM Bacterial OB fold (BOF) protein
FH977_RS12685	COG1764	response to oxidative stress
FH977_RS12710	COG3781	membrane
FH977_RS12715	COG0243	molybdopterin cofactor binding
FH977_RS12720	COG0583	DNA-binding transcription factor activity
FH977_RS12725	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH977_RS12730	COG2814	Major facilitator Superfamily
FH977_RS12740	COG1285	pathogenesis
FH977_RS12745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FH977_RS12755	COG0583	DNA-binding transcription factor activity
FH977_RS12775	COG0519	Catalyzes the synthesis of GMP from XMP
FH977_RS12775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FH977_RS12815	COG0596	Alpha beta hydrolase
FH977_RS12825	COG2205	protein histidine kinase activity
FH977_RS12840	COG0076	glutamate decarboxylase activity
FH977_RS12845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH977_RS12850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH977_RS12855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH977_RS12860	COG1116	anion transmembrane transporter activity
FH977_RS12865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FH977_RS12875	COG0673	inositol 2-dehydrogenase activity
FH977_RS12890	COG3706	GGDEF domain
FH977_RS12895	COG0402	S-adenosylhomocysteine deaminase activity
FH977_RS12900	COG1953	Uracil, thiamine, allantoin
FH977_RS12935	COG0406	alpha-ribazole phosphatase activity
FH977_RS12945	COG1335	isochorismatase
FH977_RS12965	COG2207	Transcriptional regulator
FH977_RS12985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH977_RS13050	COG0765	amino acid transport
FH977_RS13060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FH977_RS13070	COG2070	2-Nitropropane dioxygenase
FH977_RS13075	COG0583	DNA-binding transcription factor activity
FH977_RS13085	COG1902	pentaerythritol trinitrate reductase activity
FH977_RS13090	COG4529	Protein conserved in bacteria
FH977_RS13095	COG0477	Major facilitator Superfamily
FH977_RS13125	COG2223	nitrite transmembrane transporter activity
FH977_RS13135	COG1609	Transcriptional regulator
FH977_RS13140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS13150	COG3037	sugar-specific permease SgaT UlaA
FH977_RS13155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FH977_RS13165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH977_RS13170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FH977_RS13170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH977_RS13170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH977_RS13185	COG0583	DNA-binding transcription factor activity
FH977_RS13190	COG0583	DNA-binding transcription factor activity
FH977_RS13195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH977_RS13205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH977_RS13220	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS13230	COG1609	Transcriptional regulator
FH977_RS13260	COG1652	LysM domain
FH977_RS13285	COG0456	acetyltransferase
FH977_RS13285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FH977_RS13295	COG0667	Aldo Keto reductase
FH977_RS13300	COG0667	Aldo Keto reductase
FH977_RS13305	COG3386	PFAM SMP-30 Gluconolaconase
FH977_RS13310	COG0667	Aldo Keto reductase
FH977_RS13330	COG4977	sequence-specific DNA binding
FH977_RS13335	COG1349	DNA-binding transcription factor activity
FH977_RS13350	COG1349	DNA-binding transcription factor activity
FH977_RS13355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FH977_RS13360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH977_RS13365	COG0738	Major facilitator superfamily
FH977_RS13410	COG1929	Belongs to the glycerate kinase type-1 family
FH977_RS13415	COG3835	regulator
FH977_RS13435	COG2186	Transcriptional regulator
FH977_RS13440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS13440	COG1263	PTS System
FH977_RS13450	COG2814	Major facilitator Superfamily
FH977_RS13455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS13455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS13465	COG2819	hydrolase of the alpha beta superfamily
FH977_RS13470	COG5001	Diguanylate cyclase
FH977_RS13470	COG3300	MHYT domain
FH977_RS13505	COG3188	usher protein
FH977_RS13520	COG1649	PFAM Uncharacterised BCR, COG1649
FH977_RS13530	COG1396	sequence-specific DNA binding
FH977_RS13535	COG2351	hydroxyisourate hydrolase activity
FH977_RS13540	COG3195	allantoin biosynthetic process
FH977_RS13540	COG3648	Uricase
FH977_RS13545	COG2233	PERMEase
FH977_RS13575	COG2207	Transcriptional regulator
FH977_RS13590	COG4628	conserved protein (DUF2132)
FH977_RS13610	COG2011	ABC-type metal ion transport system permease component
FH977_RS13615	COG2070	2-Nitropropane dioxygenase
FH977_RS13625	COG0477	Major facilitator Superfamily
FH977_RS13705	COG2199	diguanylate cyclase activity
FH977_RS13720	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS13725	COG0583	DNA-binding transcription factor activity
FH977_RS13735	COG0039	L-malate dehydrogenase activity
FH977_RS13740	COG1349	DNA-binding transcription factor activity
FH977_RS13745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FH977_RS13750	COG3395	kinase activity
FH977_RS13760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH977_RS13765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH977_RS13770	COG2271	Major facilitator Superfamily
FH977_RS13795	COG4977	sequence-specific DNA binding
FH977_RS13805	COG0697	spore germination
FH977_RS13810	COG2814	Major facilitator Superfamily
FH977_RS13840	COG0683	leucine binding
FH977_RS13845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FH977_RS13880	COG2223	nitrite transmembrane transporter activity
FH977_RS13885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FH977_RS13900	COG1349	DNA-binding transcription factor activity
FH977_RS13910	COG2084	Dehydrogenase
FH977_RS13915	COG3395	kinase activity
FH977_RS13920	COG0235	Class ii aldolase
FH977_RS13925	COG3622	Belongs to the hyi family
FH977_RS13930	COG2610	gluconate transmembrane transporter activity
FH977_RS13935	COG3708	Transcriptional regulator
FH977_RS13935	COG2207	Transcriptional regulator
FH977_RS13955	COG2200	EAL domain
FH977_RS13960	COG1546	Belongs to the CinA family
FH977_RS13965	COG0071	Belongs to the small heat shock protein (HSP20) family
FH977_RS13975	COG2197	response regulator
FH977_RS14005	COG4221	oxidoreductase activity
FH977_RS14010	COG1802	Transcriptional regulator
FH977_RS14015	COG0589	response to stress
FH977_RS14020	COG0246	Mannitol dehydrogenase
FH977_RS14025	COG2271	Major facilitator Superfamily
FH977_RS14040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH977_RS14055	COG0243	molybdopterin cofactor binding
FH977_RS14060	COG0437	4 iron, 4 sulfur cluster binding
FH977_RS14065	COG3302	dmso reductase anchor subunit
FH977_RS14080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FH977_RS14085	COG1940	carbohydrate kinase activity
FH977_RS14090	COG0583	DNA-binding transcription factor activity
FH977_RS14095	COG2814	Major facilitator Superfamily
FH977_RS14100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FH977_RS14110	COG3591	Belongs to the peptidase S1B family
FH977_RS14130	COG0628	permease
FH977_RS14160	COG0679	Auxin Efflux Carrier
FH977_RS14170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FH977_RS14195	COG3290	protein histidine kinase activity
FH977_RS14200	COG4565	transcriptional regulatory protein
FH977_RS14220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FH977_RS14220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FH977_RS14235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH977_RS14240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FH977_RS14250	COG0183	Belongs to the thiolase family
FH977_RS14255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FH977_RS14265	COG1414	Transcriptional regulator
FH977_RS14270	COG2840	Smr protein MutS2
FH977_RS14275	COG0583	DNA-binding transcription factor activity
FH977_RS14285	COG1473	amidohydrolase
FH977_RS14290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FH977_RS14305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH977_RS14320	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FH977_RS14325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FH977_RS14345	COG0531	amino acid
FH977_RS14355	COG3136	membrane protein required for alginate biosynthesis
FH977_RS14360	COG0745	RESPONSE REGULATOR receiver
FH977_RS14370	COG2205	protein histidine kinase activity
FH977_RS14380	COG0114	fumarate hydratase activity
FH977_RS14385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FH977_RS14385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FH977_RS14390	COG1482	cell wall glycoprotein biosynthetic process
FH977_RS14395	COG5339	Protein conserved in bacteria
FH977_RS14400	COG1609	Transcriptional regulator
FH977_RS14405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS14405	COG1263	PTS System
FH977_RS14410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FH977_RS14435	COG2391	methyltransferase activity
FH977_RS14440	COG0425	Belongs to the sulfur carrier protein TusA family
FH977_RS14445	COG5562	phage envelope protein
FH977_RS14450	COG0401	homolog of Blt101
FH977_RS14455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FH977_RS14460	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS14465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FH977_RS14475	COG1113	amino acid transport
FH977_RS14480	COG2988	succinylglutamate desuccinylase activity
FH977_RS14485	COG3724	N-succinylarginine dihydrolase activity
FH977_RS14490	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS14495	COG3138	arginine N-succinyltransferase
FH977_RS14500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH977_RS14505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FH977_RS14510	COG0667	Aldo Keto reductase
FH977_RS14515	COG0583	DNA-binding transcription factor activity
FH977_RS14540	COG4122	O-methyltransferase activity
FH977_RS14545	COG1643	Atp-dependent helicase
FH977_RS14560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FH977_RS14565	COG3327	negative regulation of DNA-templated transcription, initiation
FH977_RS14570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FH977_RS14575	COG0183	Belongs to the thiolase family
FH977_RS14580	COG2050	protein possibly involved in aromatic compounds catabolism
FH977_RS14585	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH977_RS14590	COG1024	Enoyl-CoA hydratase
FH977_RS14595	COG1024	Enoyl-CoA hydratase
FH977_RS14600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH977_RS14605	COG2151	metal-sulfur cluster biosynthetic enzyme
FH977_RS14610	COG3396	Phenylacetate-CoA oxygenase
FH977_RS14615	COG3460	Phenylacetate-CoA oxygenase
FH977_RS14620	COG3396	Phenylacetate-CoA oxygenase
FH977_RS14625	COG2030	dehydratase
FH977_RS14625	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS14645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH977_RS14665	COG0583	DNA-binding transcription factor activity
FH977_RS14675	COG1126	abc transporter atp-binding protein
FH977_RS14685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS14700	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS14710	COG3784	Protein of unknown function (DUF1318)
FH977_RS14720	COG2911	Protein conserved in bacteria
FH977_RS14725	COG0586	Pfam SNARE associated Golgi protein
FH977_RS14730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FH977_RS14735	COG3187	Heat shock protein
FH977_RS14740	COG3042	response to heat
FH977_RS14750	COG1013	pyruvate-flavodoxin oxidoreductase activity
FH977_RS14750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FH977_RS14750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH977_RS14750	COG0674	pyruvate-flavodoxin oxidoreductase activity
FH977_RS14755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FH977_RS14765	COG0589	response to stress
FH977_RS14775	COG0513	Belongs to the DEAD box helicase family
FH977_RS14790	COG1349	DNA-binding transcription factor activity
FH977_RS14795	COG0673	inositol 2-dehydrogenase activity
FH977_RS14815	COG1522	sequence-specific DNA binding
FH977_RS14825	COG1448	Aminotransferase
FH977_RS14830	COG2011	ABC-type metal ion transport system permease component
FH977_RS14845	COG0436	Aminotransferase
FH977_RS14850	COG0604	alcohol dehydrogenase
FH977_RS14875	COG0583	DNA-binding transcription factor activity
FH977_RS14900	COG1309	transcriptional regulator
FH977_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS14990	COG2885	chlorophyll binding
FH977_RS15015	COG0693	protein deglycase activity
FH977_RS15020	COG1078	dGTPase activity
FH977_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS15030	COG0583	DNA-binding transcription factor activity
FH977_RS15050	COG0656	L-ascorbic acid biosynthetic process
FH977_RS15085	COG2866	Carboxypeptidase
FH977_RS15090	COG4948	Mandelate Racemase Muconate Lactonizing
FH977_RS15095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FH977_RS15100	COG3180	Ammonia monooxygenase
FH977_RS15110	COG1486	melibiose metabolic process
FH977_RS15115	COG0583	DNA-binding transcription factor activity
FH977_RS15125	COG3106	COG3106 Predicted ATPase
FH977_RS15135	COG1983	PspC domain protein
FH977_RS15145	COG1842	Phage shock protein A
FH977_RS15150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FH977_RS15160	COG1473	amidohydrolase
FH977_RS15175	COG0702	epimerase
FH977_RS15190	COG4171	peptide transport system, permease
FH977_RS15205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FH977_RS15215	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FH977_RS15220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH977_RS15220	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH977_RS15235	COG1349	DNA-binding transcription factor activity
FH977_RS15245	COG0023	Translation Initiation Factor
FH977_RS15255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FH977_RS15260	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FH977_RS15265	COG0671	phosphoesterase, PA-phosphatase related
FH977_RS15275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FH977_RS15300	COG0616	signal peptide processing
FH977_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS15315	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FH977_RS15325	COG0583	DNA-binding transcription factor activity
FH977_RS15335	COG0009	L-threonylcarbamoyladenylate synthase
FH977_RS15345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FH977_RS15350	COG0512	Glutamine amidotransferase of anthranilate synthase
FH977_RS15350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FH977_RS15355	COG0134	indole-3-glycerol-phosphate synthase activity
FH977_RS15355	COG0135	phosphoribosylanthranilate isomerase activity
FH977_RS15390	COG4774	siderophore transport
FH977_RS15400	COG3047	cAMP biosynthetic process
FH977_RS15405	COG0727	PFAM Uncharacterised protein family (UPF0153)
FH977_RS15435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH977_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS15445	COG1988	membrane-bound metal-dependent
FH977_RS15450	COG1823	symporter activity
FH977_RS15470	COG1486	melibiose metabolic process
FH977_RS15475	COG2169	Transcriptional regulator
FH977_RS15475	COG1917	Cupin 2, conserved barrel domain protein
FH977_RS15480	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH977_RS15485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS15490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS15495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH977_RS15505	COG0322	excinuclease ABC activity
FH977_RS15510	COG3678	ATP-independent chaperone mediated protein folding
FH977_RS15520	COG3724	N-succinylarginine dihydrolase activity
FH977_RS15530	COG3138	arginine N-succinyltransferase
FH977_RS15540	COG0708	Exodeoxyribonuclease III
FH977_RS15545	COG0398	Pfam SNARE associated Golgi protein
FH977_RS15550	COG0398	Pfam SNARE associated Golgi protein
FH977_RS15555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH977_RS15560	COG4134	Bacterial extracellular solute-binding protein
FH977_RS15565	COG4135	transport system, permease component
FH977_RS15570	COG4136	ATPase activity
FH977_RS15575	COG2897	thiosulfate sulfurtransferase activity
FH977_RS15580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FH977_RS15585	COG0494	nUDIX hydrolase
FH977_RS15590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FH977_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS15595	COG0604	alcohol dehydrogenase
FH977_RS15595	COG3321	synthase
FH977_RS15600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FH977_RS15605	COG0709	Synthesizes selenophosphate from selenide and ATP
FH977_RS15625	COG0778	Nitroreductase
FH977_RS15630	COG0616	signal peptide processing
FH977_RS15635	COG0252	asparaginase activity
FH977_RS15640	COG1335	isochorismatase
FH977_RS15655	COG3139	Protein of unknown function (DUF1315)
FH977_RS15675	COG0656	L-ascorbic acid biosynthetic process
FH977_RS15680	COG3713	MltA-interacting MipA family protein
FH977_RS15685	COG2766	serine protein kinase
FH977_RS15700	COG0386	Belongs to the glutathione peroxidase family
FH977_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS15725	COG0583	DNA-binding transcription factor activity
FH977_RS15730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FH977_RS15735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FH977_RS15745	COG0859	PFAM glycosyl transferase family 9
FH977_RS15750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FH977_RS15760	COG2207	Transcriptional regulator
FH977_RS15765	COG2807	transmembrane transport
FH977_RS15770	COG0504	CTP synthase activity
FH977_RS15775	COG1683	Conserved Protein
FH977_RS15780	COG3189	MarR family transcriptional regulator
FH977_RS15785	COG3042	response to heat
FH977_RS15790	COG2203	Gaf domain
FH977_RS15790	COG2199	diguanylate cyclase activity
FH977_RS15820	COG1560	Kdo2-lipid A biosynthetic process
FH977_RS15830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FH977_RS15835	COG3706	GGDEF domain
FH977_RS15840	COG0583	DNA-binding transcription factor activity
FH977_RS15845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FH977_RS15870	COG1294	oxidase, subunit
FH977_RS15875	COG1271	oxidase subunit
FH977_RS15880	COG3546	catalase activity
FH977_RS15885	COG3685	Protein conserved in bacteria
FH977_RS15890	COG3685	Protein conserved in bacteria
FH977_RS15895	COG3729	General stress protein
FH977_RS15900	COG1063	alcohol dehydrogenase
FH977_RS15905	COG3813	Protein conserved in bacteria
FH977_RS15925	COG0640	Transcriptional regulator
FH977_RS15930	COG0538	isocitrate dehydrogenase activity
FH977_RS15940	COG3300	MHYT domain
FH977_RS15940	COG5001	Diguanylate cyclase
FH977_RS15945	COG3706	GGDEF domain
FH977_RS16035	COG0616	signal peptide processing
FH977_RS16050	COG1802	Transcriptional regulator
FH977_RS16050	COG4626	Terminase
FH977_RS16170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FH977_RS16180	COG0582	viral genome integration into host DNA
FH977_RS16185	COG0538	isocitrate dehydrogenase activity
FH977_RS16190	COG1187	pseudouridine synthase activity
FH977_RS16210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FH977_RS16230	COG2205	protein histidine kinase activity
FH977_RS16235	COG2850	peptidyl-arginine hydroxylation
FH977_RS16240	COG1943	Transposase
FH977_RS16265	COG1177	transmembrane transport
FH977_RS16280	COG0318	PFAM AMP-dependent synthetase and ligase
FH977_RS16285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FH977_RS16290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH977_RS16295	COG0698	ribose 5-phosphate isomerase
FH977_RS16310	COG3395	kinase activity
FH977_RS16325	COG2390	Transcriptional regulator
FH977_RS16335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FH977_RS16345	COG4591	ABC-type transport system involved in lipoprotein release permease component
FH977_RS16355	COG4591	ABC-type transport system involved in lipoprotein release permease component
FH977_RS16365	COG1376	ErfK ybiS ycfS ynhG family protein
FH977_RS16365	COG1388	LysM domain
FH977_RS16375	COG1309	transcriptional regulator
FH977_RS16385	COG3134	Outer membrane lipoprotein
FH977_RS16390	COG1252	NADH dehydrogenase
FH977_RS16415	COG5633	Lipoprotein
FH977_RS16420	COG0537	adenosine 5'-monophosphoramidase activity
FH977_RS16430	COG0084	hydrolase, TatD family'
FH977_RS16435	COG0470	DNA polymerase III
FH977_RS16445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FH977_RS16450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FH977_RS16455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH977_RS16470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FH977_RS16490	COG1399	metal-binding, possibly nucleic acid-binding protein
FH977_RS16505	COG1530	ribonuclease E activity
FH977_RS16510	COG0583	DNA-binding transcription factor activity
FH977_RS16515	COG2814	Major facilitator Superfamily
FH977_RS16535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH977_RS16585	COG1560	Kdo2-lipid A biosynthetic process
FH977_RS16600	COG5645	(Lipo)protein
FH977_RS16635	COG3381	protein complex oligomerization
FH977_RS16655	COG0583	DNA-binding transcription factor activity
FH977_RS16665	COG1335	isochorismatase
FH977_RS16680	COG1702	phosphate starvation-inducible protein PhoH
FH977_RS16700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FH977_RS16710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH977_RS16725	COG1309	transcriptional regulator
FH977_RS16760	COG2233	PERMEase
FH977_RS16770	COG3729	General stress protein
FH977_RS16795	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS16810	COG0531	amino acid
FH977_RS16815	COG0174	glutamine synthetase
FH977_RS16820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FH977_RS16825	COG1917	Cupin 2, conserved barrel domain protein
FH977_RS16825	COG1396	sequence-specific DNA binding
FH977_RS16830	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS16835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH977_RS16840	COG0583	DNA-binding transcription factor activity
FH977_RS16845	COG0473	3-isopropylmalate dehydrogenase activity
FH977_RS16850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FH977_RS16855	COG4638	Rieske (2fe-2S)
FH977_RS16860	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS16865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH977_RS16890	COG0670	Belongs to the BI1 family
FH977_RS16905	COG2207	Transcriptional regulator
FH977_RS16910	COG1881	PFAM PEBP family protein
FH977_RS16935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS16940	COG2274	protein secretion by the type I secretion system
FH977_RS16955	COG1832	CoA-binding protein
FH977_RS16965	COG0210	DNA helicase
FH977_RS16970	COG3304	Inner membrane component domain
FH977_RS16975	COG1289	transmembrane transporter activity
FH977_RS16980	COG3070	regulator of competence-specific genes
FH977_RS17005	COG1067	ATP-dependent peptidase activity
FH977_RS17015	COG3130	regulation of translation
FH977_RS17020	COG3009	Protein conserved in bacteria
FH977_RS17025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FH977_RS17025	COG3008	intermembrane lipid transfer
FH977_RS17030	COG2995	paraquat-inducible protein a
FH977_RS17035	COG0488	(ABC) transporter
FH977_RS17045	COG3217	Mosc domain protein beta barrel domain protein
FH977_RS17045	COG0633	Ferredoxin
FH977_RS17060	COG0431	NADPH-dependent FMN reductase
FH977_RS17065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH977_RS17070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH977_RS17075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH977_RS17085	COG0308	aminopeptidase N
FH977_RS17095	COG1473	amidohydrolase
FH977_RS17105	COG0814	amino acid
FH977_RS17115	COG1522	sequence-specific DNA binding
FH977_RS17125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FH977_RS17130	COG1448	Aminotransferase
FH977_RS17135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH977_RS17140	COG3108	Peptidase M15
FH977_RS17145	COG2989	Protein conserved in bacteria
FH977_RS17155	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FH977_RS17165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FH977_RS17170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FH977_RS17175	COG3173	Aminoglycoside phosphotransferase
FH977_RS17190	COG3214	Protein conserved in bacteria
FH977_RS17205	COG0658	competence protein
FH977_RS17205	COG2333	competence protein COMEC
FH977_RS17215	COG0539	negative regulation of cytoplasmic translation
FH977_RS17235	COG2323	membrane
FH977_RS17240	COG1944	ATP diphosphatase activity
FH977_RS17245	COG2116	formate transmembrane transporter activity
FH977_RS17250	COG1882	Formate acetyltransferase
FH977_RS17255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FH977_RS17260	COG0477	Major facilitator Superfamily
FH977_RS17275	COG0437	4 iron, 4 sulfur cluster binding
FH977_RS17280	COG0243	molybdopterin cofactor binding
FH977_RS17290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FH977_RS17300	COG1178	ABC-type Fe3 transport system permease component
FH977_RS17300	COG1674	ftsk spoiiie
FH977_RS17310	COG0492	ferredoxin-NADP+ reductase activity
FH977_RS17315	COG4988	ABC transporter
FH977_RS17320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FH977_RS17335	COG0542	response to heat
FH977_RS17345	COG1278	Cold shock
FH977_RS17355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS17360	COG3593	DNA synthesis involved in DNA repair
FH977_RS17370	COG2431	L-lysine efflux transmembrane transporter activity
FH977_RS17380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH977_RS17390	COG0028	Belongs to the TPP enzyme family
FH977_RS17395	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FH977_RS17400	COG0702	epimerase
FH977_RS17405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH977_RS17410	COG3023	N-Acetylmuramoyl-L-alanine amidase
FH977_RS17415	COG2203	Gaf domain
FH977_RS17415	COG3706	GGDEF domain
FH977_RS17415	COG5001	Diguanylate cyclase
FH977_RS17415	COG4251	negative regulation of phosphorylation
FH977_RS17425	COG1126	abc transporter atp-binding protein
FH977_RS17430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS17435	COG4215	(ABC) transporter
FH977_RS17440	COG4160	amino acid transport
FH977_RS17445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS17450	COG5002	protein histidine kinase activity
FH977_RS17455	COG0745	RESPONSE REGULATOR receiver
FH977_RS17470	COG1177	transmembrane transport
FH977_RS17475	COG1176	ABC-type spermidine putrescine transport system, permease component I
FH977_RS17480	COG3842	ATPase activity
FH977_RS17485	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FH977_RS17500	COG0778	Nitroreductase
FH977_RS17525	COG3226	Transcriptional regulator
FH977_RS17530	COG0738	Major facilitator superfamily
FH977_RS17535	COG0561	phosphatase activity
FH977_RS17540	COG2814	Major facilitator Superfamily
FH977_RS17550	COG0671	phosphoesterase, PA-phosphatase related
FH977_RS17555	COG1349	DNA-binding transcription factor activity
FH977_RS17560	COG1686	Belongs to the peptidase S11 family
FH977_RS17570	COG0625	glutathione transferase activity
FH977_RS17575	COG2133	pyrroloquinoline quinone binding
FH977_RS17585	COG2223	nitrite transmembrane transporter activity
FH977_RS17605	COG0747	negative chemotaxis
FH977_RS17620	COG0303	'Molybdopterin
FH977_RS17625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FH977_RS17630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FH977_RS17635	COG1882	Formate acetyltransferase
FH977_RS17640	COG0561	phosphatase activity
FH977_RS17650	COG1609	Transcriptional regulator
FH977_RS17655	COG2271	Major facilitator Superfamily
FH977_RS17665	COG0488	(ABC) transporter
FH977_RS17670	COG2365	Tyrosine phosphatase family
FH977_RS17675	COG1376	ErfK ybiS ycfS ynhG family protein
FH977_RS17680	COG2188	Transcriptional regulator
FH977_RS17685	COG2723	6-phospho-beta-galactosidase activity
FH977_RS17690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FH977_RS17705	COG2194	sulfuric ester hydrolase activity
FH977_RS17710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FH977_RS17725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS17730	COG0765	amino acid transport
FH977_RS17735	COG1126	abc transporter atp-binding protein
FH977_RS17740	COG0668	transmembrane transport
FH977_RS17750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FH977_RS17760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FH977_RS17770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FH977_RS17775	COG1199	ATP-dependent helicase activity
FH977_RS17780	COG0513	Belongs to the DEAD box helicase family
FH977_RS17785	COG3958	Transketolase
FH977_RS17790	COG3959	Transketolase, thiamine diphosphate binding domain
FH977_RS17795	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS17800	COG2271	Major facilitator Superfamily
FH977_RS17805	COG0583	DNA-binding transcription factor activity
FH977_RS17810	COG1309	transcriptional regulator
FH977_RS17815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS17820	COG1131	(ABC) transporter
FH977_RS17825	COG0842	Transport permease protein
FH977_RS17830	COG0842	Transport permease protein
FH977_RS17840	COG3568	Endonuclease Exonuclease Phosphatase
FH977_RS17845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FH977_RS17850	COG0392	lysyltransferase activity
FH977_RS17865	COG0670	Belongs to the BI1 family
FH977_RS17870	COG0314	molybdopterin synthase activity
FH977_RS17875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FH977_RS17885	COG0521	Mo-molybdopterin cofactor biosynthetic process
FH977_RS17910	COG0745	RESPONSE REGULATOR receiver
FH977_RS17915	COG0642	Histidine kinase
FH977_RS17945	COG2226	methyltransferase
FH977_RS17960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FH977_RS17965	COG1881	PFAM PEBP family protein
FH977_RS18000	COG4677	pectinesterase activity
FH977_RS18010	COG0589	response to stress
FH977_RS18015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS18045	COG0789	Transcriptional regulator
FH977_RS18050	COG2200	EAL domain
FH977_RS18075	COG0561	phosphatase activity
FH977_RS18090	COG0725	ABC transporter, periplasmic molybdate-binding protein
FH977_RS18100	COG2005	Transcriptional regulator
FH977_RS18100	COG3585	molybdate ion transport
FH977_RS18105	COG1119	ATPase activity
FH977_RS18115	COG1085	galactose-1-phosphate uridylyltransferase
FH977_RS18125	COG2017	converts alpha-aldose to the beta-anomer
FH977_RS18135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FH977_RS18150	COG3201	nicotinamide mononucleotide transporter
FH977_RS18155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FH977_RS18200	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FH977_RS18205	COG2885	chlorophyll binding
FH977_RS18215	COG3064	Membrane
FH977_RS18215	COG3064	Membrane
FH977_RS18220	COG0848	biopolymer transport protein
FH977_RS18225	COG0811	peptide transport
FH977_RS18230	COG0824	Thioesterase
FH977_RS18235	COG3790	cyd operon protein YbgE
FH977_RS18240	COG4890	Cyd operon protein YbgT
FH977_RS18245	COG1294	oxidase, subunit
FH977_RS18250	COG1271	oxidase subunit
FH977_RS18260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FH977_RS18270	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH977_RS18280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FH977_RS18285	COG1053	succinate dehydrogenase
FH977_RS18290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FH977_RS18295	COG2009	succinate dehydrogenase
FH977_RS18330	COG1984	allophanate hydrolase subunit 2
FH977_RS18335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FH977_RS18385	COG0745	RESPONSE REGULATOR receiver
FH977_RS18395	COG0033	Phosphoglucomutase
FH977_RS18405	COG0596	Alpha beta hydrolase
FH977_RS18420	COG0735	belongs to the Fur family
FH977_RS18460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FH977_RS18465	COG1940	carbohydrate kinase activity
FH977_RS18465	COG1846	Transcriptional regulator
FH977_RS18470	COG0647	UMP catabolic process
FH977_RS18475	COG0367	asparagine synthase
FH977_RS18520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH977_RS18530	COG1702	phosphate starvation-inducible protein PhoH
FH977_RS18555	COG0765	amino acid transport
FH977_RS18560	COG0765	amino acid transport
FH977_RS18565	COG1126	abc transporter atp-binding protein
FH977_RS18580	COG2888	peptidyl-tyrosine sulfation
FH977_RS18595	COG1466	dna polymerase III delta subunit
FH977_RS18610	COG0799	negative regulation of ribosome biogenesis
FH977_RS18620	COG0768	penicillin binding
FH977_RS18625	COG0772	Belongs to the SEDS family
FH977_RS18630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FH977_RS18635	COG1686	Belongs to the peptidase S11 family
FH977_RS18650	COG0583	DNA-binding transcription factor activity
FH977_RS18665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH977_RS18685	COG3069	C4-dicarboxylate transmembrane transporter activity
FH977_RS18690	COG3719	Belongs to the RNase T2 family
FH977_RS18695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FH977_RS18715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FH977_RS18720	COG0583	DNA-binding transcription factor activity
FH977_RS18725	COG3969	phosphoadenosine phosphosulfate
FH977_RS18735	COG0436	Aminotransferase
FH977_RS18760	COG1129	ABC transporter
FH977_RS18765	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS18770	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS18780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH977_RS18795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FH977_RS18805	COG0402	S-adenosylhomocysteine deaminase activity
FH977_RS18815	COG0483	inositol monophosphate 1-phosphatase activity
FH977_RS18820	COG2271	Major facilitator Superfamily
FH977_RS18850	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS18855	COG1129	ABC transporter
FH977_RS18860	COG0371	Dehydrogenase
FH977_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS18880	COG2879	small protein
FH977_RS18885	COG1966	Carbon starvation protein
FH977_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS18900	COG3433	isochorismatase activity
FH977_RS18900	COG1535	isochorismatase
FH977_RS18905	COG1021	2,3-dihydroxybenzoate-AMP ligase
FH977_RS18910	COG1169	isochorismate synthase
FH977_RS18915	COG4592	Periplasmic binding protein
FH977_RS18925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS18930	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS18935	COG1120	ATPase activity
FH977_RS18940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH977_RS18940	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FH977_RS18945	COG3251	PFAM MbtH domain protein
FH977_RS18950	COG2382	esterase
FH977_RS18955	COG4771	TonB-dependent receptor
FH977_RS18965	COG1879	ABC-type sugar transport system periplasmic component
FH977_RS18975	COG1129	ABC transporter
FH977_RS18980	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS18985	COG5464	transposase or invertase
FH977_RS18990	COG2390	Transcriptional regulator
FH977_RS18995	COG3959	Transketolase, thiamine diphosphate binding domain
FH977_RS19000	COG3958	Transketolase
FH977_RS19010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FH977_RS19020	COG0583	DNA-binding transcription factor activity
FH977_RS19025	COG0668	transmembrane transport
FH977_RS19035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FH977_RS19060	COG0747	negative chemotaxis
FH977_RS19065	COG0601	transmembrane transport
FH977_RS19070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH977_RS19075	COG0444	Belongs to the ABC transporter superfamily
FH977_RS19080	COG4608	Belongs to the ABC transporter superfamily
FH977_RS19090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FH977_RS19095	COG4221	oxidoreductase activity
FH977_RS19105	COG4215	(ABC) transporter
FH977_RS19110	COG0765	amino acid transport
FH977_RS19115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FH977_RS19130	COG0697	spore germination
FH977_RS19140	COG3698	Phosphodiester glycosidase
FH977_RS19190	COG2315	Protein conserved in bacteria
FH977_RS19195	COG0778	Nitroreductase
FH977_RS19205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS19215	COG3716	PTS system mannose fructose sorbose family IID component
FH977_RS19220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH977_RS19225	COG2222	sugar isomerase
FH977_RS19230	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FH977_RS19230	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FH977_RS19245	COG0477	Major facilitator Superfamily
FH977_RS19250	COG0668	transmembrane transport
FH977_RS19255	COG1609	Transcriptional regulator
FH977_RS19265	COG0673	inositol 2-dehydrogenase activity
FH977_RS19275	COG2211	Major facilitator Superfamily
FH977_RS19295	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS19300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH977_RS19310	COG0531	amino acid
FH977_RS19355	COG0667	Aldo Keto reductase
FH977_RS19360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS19365	COG1473	amidohydrolase
FH977_RS19385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS19390	COG1120	ATPase activity
FH977_RS19395	COG1566	PFAM secretion protein HlyD family protein
FH977_RS19440	COG4211	Belongs to the binding-protein-dependent transport system permease family
FH977_RS19460	COG0673	inositol 2-dehydrogenase activity
FH977_RS19490	COG3104	oligopeptide transport
FH977_RS19495	COG1982	Orn Lys Arg decarboxylase major
FH977_RS19500	COG0531	amino acid
FH977_RS19505	COG3710	Transcriptional regulator
FH977_RS19520	COG1560	Kdo2-lipid A biosynthetic process
FH977_RS19535	COG3188	usher protein
FH977_RS19540	COG3121	Chaperone
FH977_RS19545	COG3539	Fimbrial protein
FH977_RS19740	COG3772	lysozyme
FH977_RS19920	COG0582	viral genome integration into host DNA
FH977_RS19940	COG2501	S4 domain
FH977_RS19950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FH977_RS19965	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FH977_RS19970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FH977_RS19985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FH977_RS19990	COG4181	ATPase activity
FH977_RS19995	COG2755	lipolytic protein G-D-S-L family
FH977_RS20000	COG0300	oxidoreductase activity
FH977_RS20005	COG3118	belongs to the thioredoxin family
FH977_RS20015	COG0390	transport system, permease component
FH977_RS20020	COG4619	ABC transporter
FH977_RS20025	COG0330	HflC and HflK could
FH977_RS20030	COG1585	Membrane protein implicated in regulation of membrane protease activity
FH977_RS20045	COG3735	TraB family
FH977_RS20050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FH977_RS20060	COG2223	nitrite transmembrane transporter activity
FH977_RS20065	COG4651	solute:proton antiporter activity
FH977_RS20065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FH977_RS20070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH977_RS20110	COG2832	Protein of unknown function (DUF454)
FH977_RS20115	COG3923	Primosomal replication protein n
FH977_RS20130	COG3264	Mechanosensitive ion channel
FH977_RS20130	COG1196	nuclear chromosome segregation
FH977_RS20135	COG1309	transcriptional regulator
FH977_RS20140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS20145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH977_RS20160	COG0110	maltose O-acetyltransferase activity
FH977_RS20205	COG1874	Beta-galactosidase
FH977_RS20210	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FH977_RS20220	COG1175	transmembrane transport
FH977_RS20235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FH977_RS20250	COG2364	Membrane
FH977_RS20280	COG3695	enzyme binding
FH977_RS20285	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FH977_RS20290	COG1946	Acyl-CoA thioesterase
FH977_RS20295	COG0004	ammonium transporteR
FH977_RS20300	COG0347	Belongs to the P(II) protein family
FH977_RS20305	COG1132	(ABC) transporter
FH977_RS20310	COG1132	(ABC) transporter
FH977_RS20315	COG1522	sequence-specific DNA binding
FH977_RS20330	COG4533	DNA binding
FH977_RS20340	COG0824	Thioesterase
FH977_RS20345	COG1555	photosystem II stabilization
FH977_RS20350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FH977_RS20355	COG0776	regulation of translation
FH977_RS20360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FH977_RS20390	COG0271	Belongs to the BolA IbaG family
FH977_RS20395	COG3056	Lipoprotein
FH977_RS20405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FH977_RS20410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FH977_RS20415	COG1845	cytochrome c oxidase, subunit III
FH977_RS20420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FH977_RS20435	COG1414	Transcriptional regulator
FH977_RS20440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FH977_RS20445	COG1053	succinate dehydrogenase
FH977_RS20455	COG1053	succinate dehydrogenase
FH977_RS20470	COG0673	inositol 2-dehydrogenase activity
FH977_RS20475	COG2814	Major facilitator Superfamily
FH977_RS20485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FH977_RS20490	COG0693	protein deglycase activity
FH977_RS20510	COG0142	geranyltranstransferase activity
FH977_RS20520	COG0667	Aldo Keto reductase
FH977_RS20525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FH977_RS20545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FH977_RS20545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FH977_RS20555	COG4238	major outer membrane lipoprotein
FH977_RS20575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH977_RS20580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH977_RS20585	COG1862	Preprotein translocase
FH977_RS20605	COG0450	alkyl hydroperoxide reductase
FH977_RS20610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS20625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH977_RS20635	COG1228	amidohydrolase
FH977_RS20645	COG1335	isochorismatase
FH977_RS20650	COG0583	DNA-binding transcription factor activity
FH977_RS20655	COG0366	Alpha amylase catalytic
FH977_RS20680	COG0420	3'-5' exonuclease activity
FH977_RS20685	COG0419	ATPase involved in DNA repair
FH977_RS20690	COG1940	carbohydrate kinase activity
FH977_RS20705	COG4126	flavin adenine dinucleotide binding
FH977_RS20715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FH977_RS20720	COG3416	Protein conserved in bacteria
FH977_RS20730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FH977_RS20740	COG1785	Belongs to the alkaline phosphatase family
FH977_RS20780	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FH977_RS20785	COG1335	isochorismatase
FH977_RS20790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FH977_RS20795	COG0113	porphobilinogen synthase activity
FH977_RS20810	COG2175	clavaminate synthase activity
FH977_RS20815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH977_RS20820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FH977_RS20825	COG4521	taurine ABC transporter
FH977_RS20830	COG2040	homocysteine
FH977_RS20835	COG0833	amino acid
FH977_RS20845	COG4303	Ethanolamine ammonia lyase large subunit
FH977_RS20850	COG4302	ethanolamine ammonia-lyase activity
FH977_RS20890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS20895	COG1126	abc transporter atp-binding protein
FH977_RS20900	COG4597	amino acid ABC transporter
FH977_RS20905	COG0765	amino acid transport
FH977_RS20920	COG3188	usher protein
FH977_RS20945	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FH977_RS20955	COG3639	organic phosphonate transmembrane transporter activity
FH977_RS20975	COG0791	NLP P60 protein
FH977_RS21020	COG2909	trisaccharide binding
FH977_RS21025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FH977_RS21030	COG0022	dehydrogenase e1 component
FH977_RS21075	COG1070	Carbohydrate kinase
FH977_RS21080	COG1028	Short-chain dehydrogenase reductase Sdr
FH977_RS21085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH977_RS21090	COG3775	system Galactitol-specific IIC component
FH977_RS21095	COG0625	glutathione transferase activity
FH977_RS21100	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FH977_RS21115	COG0579	oxidoreductase
FH977_RS21120	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS21125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH977_RS21130	COG1113	amino acid transport
FH977_RS21135	COG1802	Transcriptional regulator
FH977_RS21155	COG2195	Cleaves the N-terminal amino acid of tripeptides
FH977_RS21160	COG0454	-acetyltransferase
FH977_RS21175	COG2991	Protein conserved in bacteria
FH977_RS21190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FH977_RS21195	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FH977_RS21210	COG3034	peptidoglycan biosynthetic process
FH977_RS21215	COG0121	glutamine amidotransferase
FH977_RS21225	COG1960	acyl-CoA dehydrogenase activity
FH977_RS21230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH977_RS21240	COG0583	DNA-binding transcription factor activity
FH977_RS21250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FH977_RS21260	COG2226	methyltransferase
FH977_RS21270	COG0741	lytic transglycosylase activity
FH977_RS21270	COG1388	LysM domain
FH977_RS21275	COG2226	methyltransferase
FH977_RS21285	COG2814	Major facilitator Superfamily
FH977_RS21290	COG0583	DNA-binding transcription factor activity
FH977_RS21295	COG0656	L-ascorbic acid biosynthetic process
FH977_RS21330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FH977_RS21340	COG2011	ABC-type metal ion transport system permease component
FH977_RS21345	COG1464	Belongs to the NlpA lipoprotein family
FH977_RS21355	COG1720	tRNA m6t6A37 methyltransferase activity
FH977_RS21365	COG0791	NLP P60 protein
FH977_RS21370	COG3015	lipoprotein NlpE involved in copper resistance
FH977_RS21375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FH977_RS21390	COG4568	rho-dependent transcription termination
FH977_RS21400	COG0346	lactoylglutathione lyase activity
FH977_RS21415	COG0587	DNA-directed DNA polymerase activity
FH977_RS21445	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FH977_RS21455	COG0750	zinc metalloprotease
FH977_RS21460	COG0575	Belongs to the CDS family
FH977_RS21475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FH977_RS21500	COG0024	Methionine aminopeptidase
FH977_RS21505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FH977_RS21520	COG3835	regulator
FH977_RS21525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH977_RS21545	COG2860	membrane
FH977_RS21565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH977_RS21570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH977_RS21575	COG1120	ATPase activity
FH977_RS21580	COG4774	siderophore transport
FH977_RS21585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH977_RS21670	COG1643	Atp-dependent helicase
FH977_RS21675	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FH977_RS21695	COG0617	tRNA 3'-terminal CCA addition
FH977_RS21700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FH977_RS21720	COG0726	polysaccharide deacetylase
FH977_RS21725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS21730	COG0842	Transport permease protein
FH977_RS21735	COG1131	(ABC) transporter
FH977_RS21740	COG0288	reversible hydration of carbon dioxide
FH977_RS21750	COG4993	Dehydrogenase
FH977_RS21755	COG2132	Multicopper oxidase
FH977_RS21800	COG3064	Membrane
FH977_RS21815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FH977_RS21820	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH977_RS21825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FH977_RS21830	COG2186	Transcriptional regulator
FH977_RS21835	COG1113	amino acid transport
FH977_RS21840	COG2211	Major facilitator Superfamily
FH977_RS21845	COG3940	Belongs to the glycosyl hydrolase 43 family
FH977_RS21850	COG3725	Membrane protein required for beta-lactamase induction
FH977_RS21855	COG3023	N-Acetylmuramoyl-L-alanine amidase
FH977_RS21865	COG4969	Belongs to the N-Me-Phe pilin family
FH977_RS21870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FH977_RS21875	COG1459	type II secretion system
FH977_RS21900	COG0494	nUDIX hydrolase
FH977_RS21920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FH977_RS21925	COG0849	cell division
FH977_RS21950	COG0772	Belongs to the SEDS family
FH977_RS21965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FH977_RS21970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FH977_RS21975	COG0768	penicillin binding
FH977_RS21995	COG1609	Transcriptional regulator
FH977_RS22005	COG0028	Belongs to the TPP enzyme family
FH977_RS22055	COG0738	Major facilitator superfamily
FH977_RS22065	COG0583	DNA-binding transcription factor activity
FH977_RS22070	COG2271	Major facilitator Superfamily
FH977_RS22075	COG2814	Major facilitator Superfamily
FH977_RS22095	COG1178	ABC-type Fe3 transport system permease component
FH977_RS22105	COG0586	Pfam SNARE associated Golgi protein
FH977_RS22125	COG0235	Class ii aldolase
FH977_RS22130	COG0417	DNA replication proofreading
FH977_RS22140	COG0564	pseudouridine synthase activity
FH977_RS22150	COG3493	citrate carrier protein
FH977_RS22165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FH977_RS22170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FH977_RS22180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FH977_RS22225	COG0505	Belongs to the CarA family
FH977_RS22290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH977_RS22315	COG1047	Peptidyl-prolyl cis-trans
FH977_RS22330	COG0196	riboflavin kinase activity
FH977_RS22345	COG0583	DNA-binding transcription factor activity
FH977_RS22370	COG4735	regulation of single-species biofilm formation
FH977_RS22375	COG1584	GPR1 FUN34 yaaH family protein
FH977_RS22380	COG0477	Major facilitator Superfamily
FH977_RS22385	COG0521	Mo-molybdopterin cofactor biosynthetic process
FH977_RS22390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH977_RS22395	COG1115	amino acid carrier protein
FH977_RS22410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FH977_RS22420	COG0527	aspartate kinase activity
FH977_RS22420	COG0460	homoserine dehydrogenase
FH977_RS22430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FH977_RS22440	COG0745	RESPONSE REGULATOR receiver
FH977_RS22445	COG4452	Inner membrane protein CreD
FH977_RS22450	COG2205	protein histidine kinase activity
FH977_RS22455	COG0745	RESPONSE REGULATOR receiver
FH977_RS22460	COG3045	CreA protein
FH977_RS22465	COG2207	Transcriptional regulator
FH977_RS22465	COG3708	Transcriptional regulator
FH977_RS22485	COG0741	lytic transglycosylase activity
FH977_RS22490	COG0488	(ABC) transporter
FH977_RS22500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FH977_RS22505	COG0560	Phosphoserine phosphatase
FH977_RS22510	COG3726	membrane protein affecting hemolysin expression
FH977_RS22540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FH977_RS22545	COG0084	hydrolase, TatD family'
FH977_RS22550	COG4667	esterase of the alpha-beta hydrolase superfamily
FH977_RS22560	COG2823	Periplasmic or secreted lipoprotein
FH977_RS22570	COG1011	Hydrolase
FH977_RS22575	COG0456	acetyltransferase
FH977_RS22580	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FH977_RS22610	COG3706	GGDEF domain
FH977_RS22615	COG4114	ferric iron reductase
FH977_RS22620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS22620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS22625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FH977_RS22630	COG2197	response regulator
FH977_RS22635	COG2197	response regulator
FH977_RS22650	COG2966	Psort location CytoplasmicMembrane, score
FH977_RS22665	COG1484	DNA-dependent DNA replication
FH977_RS22680	COG5464	transposase or invertase
FH977_RS22690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH977_RS22695	COG3716	PTS system mannose fructose sorbose family IID component
FH977_RS22700	COG3715	PTS system
FH977_RS22715	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FH977_RS22715	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FH977_RS22720	COG0456	acetyltransferase
FH977_RS22720	COG1214	PFAM Peptidase M22, glycoprotease
FH977_RS22730	COG1737	Transcriptional regulator
FH977_RS22735	COG0800	Aldolase
FH977_RS22740	COG3734	2-keto-3-deoxy-galactonokinase
FH977_RS22755	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FH977_RS22785	COG1846	Transcriptional regulator
FH977_RS22795	COG0179	Fumarylacetoacetate (FAA) hydrolase
FH977_RS22805	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS22810	COG3384	dioxygenase
FH977_RS22820	COG3971	2-oxopent-4-enoate hydratase activity
FH977_RS22840	COG2368	4-hydroxyphenylacetate
FH977_RS22845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FH977_RS22860	COG1966	Carbon starvation protein
FH977_RS22865	COG2879	small protein
FH977_RS22870	COG0523	cobalamin synthesis protein
FH977_RS22880	COG1012	belongs to the aldehyde dehydrogenase family
FH977_RS22885	COG5464	transposase or invertase
FH977_RS22890	COG1917	Cupin 2, conserved barrel domain protein
FH977_RS22890	COG2207	Transcriptional regulator
FH977_RS22900	COG2733	membrane
FH977_RS22915	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
FH977_RS22920	COG1924	4 iron, 4 sulfur cluster binding
FH977_RS22935	COG1566	PFAM secretion protein HlyD family protein
FH977_RS22945	COG5457	Domain of unknown function (DUF1127)
FH977_RS22950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH977_RS22965	COG0583	DNA-binding transcription factor activity
FH977_RS22980	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS22985	COG1129	ABC transporter
FH977_RS22990	COG1879	ABC-type sugar transport system periplasmic component
FH977_RS23000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS23005	COG1129	ABC transporter
FH977_RS23005	COG0842	Transport permease protein
FH977_RS23010	COG0842	Transport permease protein
FH977_RS23040	COG2850	peptidyl-arginine hydroxylation
FH977_RS23055	COG5002	protein histidine kinase activity
FH977_RS23060	COG0745	RESPONSE REGULATOR receiver
FH977_RS23065	COG1538	Outer membrane efflux protein
FH977_RS23070	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS23075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH977_RS23080	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH977_RS23090	COG3040	lipid binding
FH977_RS23095	COG0789	Transcriptional regulator
FH977_RS23105	COG0300	oxidoreductase activity
FH977_RS23120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FH977_RS23140	COG3272	Protein of unknown function (DUF1722)
FH977_RS23145	COG4580	involved in the transport of maltose and maltodextrins
FH977_RS23150	COG2115	Belongs to the xylose isomerase family
FH977_RS23155	COG2211	Major facilitator Superfamily
FH977_RS23160	COG3507	Belongs to the glycosyl hydrolase 43 family
FH977_RS23215	COG0210	DNA helicase
FH977_RS23235	COG3429	Glucose-6-phosphate dehydrogenase subunit
FH977_RS23235	COG3409	Peptidoglycan-binding domain 1 protein
FH977_RS23310	COG0582	viral genome integration into host DNA
FH977_RS23320	COG0288	reversible hydration of carbon dioxide
FH977_RS23325	COG0659	secondary active sulfate transmembrane transporter activity
FH977_RS23330	COG1064	alcohol dehydrogenase
FH977_RS23335	COG1175	transmembrane transport
FH977_RS23340	COG0395	ABC-type sugar transport system, permease component
FH977_RS23345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FH977_RS23350	COG3842	ATPase activity
FH977_RS23355	COG1653	transport
FH977_RS23365	COG1082	Xylose isomerase domain protein TIM barrel
FH977_RS23375	COG3962	Belongs to the TPP enzyme family
FH977_RS23380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH977_RS23385	COG1737	Transcriptional regulator
FH977_RS23385	COG0837	glucose binding
FH977_RS23395	COG3718	enzyme involved in inositol metabolism
FH977_RS23410	COG0433	COG0433 Predicted ATPase
FH977_RS23415	COG0795	lipopolysaccharide-transporting ATPase activity
FH977_RS23420	COG0795	lipopolysaccharide-transporting ATPase activity
FH977_RS23430	COG2927	DNA polymerase III (CHI subunit)
FH977_RS23435	COG0525	valine-tRNA ligase activity
FH977_RS23460	COG2731	YhcH YjgK YiaL family protein
FH977_RS23500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH977_RS23500	COG1263	PTS System
FH977_RS23505	COG0366	Alpha amylase catalytic
FH977_RS23510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH977_RS23515	COG1486	melibiose metabolic process
FH977_RS23535	COG0602	queuosine metabolic process
FH977_RS23540	COG2026	Addiction module toxin, RelE StbE family
FH977_RS23545	COG3077	Addiction module antitoxin, RelB DinJ family
FH977_RS23550	COG3711	transcriptional antiterminator
FH977_RS23550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH977_RS23555	COG2706	6-phosphogluconolactonase activity
FH977_RS23570	COG3964	amidohydrolase
FH977_RS23605	COG0312	modulator of DNA gyrase
FH977_RS23625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FH977_RS23635	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS23640	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS23645	COG1129	ABC transporter
FH977_RS23650	COG1879	ABC-type sugar transport system periplasmic component
FH977_RS23670	COG2105	PFAM AIG2 family protein
FH977_RS23675	COG2911	Protein conserved in bacteria
FH977_RS23680	COG0729	surface antigen
FH977_RS23690	COG1253	flavin adenine dinucleotide binding
FH977_RS23705	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FH977_RS23720	COG1733	regulation of RNA biosynthetic process
FH977_RS23725	COG0702	epimerase
FH977_RS23735	COG0697	spore germination
FH977_RS23745	COG1113	amino acid transport
FH977_RS23750	COG0545	Peptidyl-prolyl cis-trans isomerase
FH977_RS23755	COG3061	Opacity-associated protein A
FH977_RS23765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FH977_RS23770	COG2965	DNA replication, synthesis of RNA primer
FH977_RS23835	COG3650	response to hydrogen peroxide
FH977_RS23845	COG1960	acyl-CoA dehydrogenase activity
FH977_RS23850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FH977_RS23855	COG0557	exoribonuclease II activity
FH977_RS23870	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FH977_RS23880	COG0330	HflC and HflK could
FH977_RS23885	COG0330	HflC and HflK could
FH977_RS23890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FH977_RS23910	COG0860	N-Acetylmuramoyl-L-alanine amidase
FH977_RS23915	COG0802	atpase or kinase
FH977_RS23920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FH977_RS23920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FH977_RS23925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FH977_RS23940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH977_RS23960	COG1511	domain protein
FH977_RS23960	COG3264	Mechanosensitive ion channel
FH977_RS23975	COG1053	succinate dehydrogenase
FH977_RS23980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FH977_RS24000	COG2076	Multidrug Resistance protein
FH977_RS24005	COG5510	response to toxic substance
FH977_RS24020	COG1509	lysine 2,3-aminomutase activity
FH977_RS24085	COG0531	amino acid
FH977_RS24090	COG3030	protein affecting phage T7 exclusion by the F plasmid
FH977_RS24095	COG1027	Aspartate ammonia-lyase
FH977_RS24100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FH977_RS24115	COG1309	transcriptional regulator
FH977_RS24145	COG0457	Tetratricopeptide repeat
FH977_RS24150	COG0726	polysaccharide deacetylase
FH977_RS24150	COG1649	PFAM Uncharacterised BCR, COG1649
FH977_RS24155	COG1215	transferase activity, transferring glycosyl groups
FH977_RS24175	COG0861	Integral membrane protein TerC family
FH977_RS24205	COG1486	melibiose metabolic process
FH977_RS24210	COG2169	Transcriptional regulator
FH977_RS24225	COG2824	Alkylphosphonate utilization operon protein PhnA
FH977_RS24230	COG2764	glyoxalase bleomycin resistance protein dioxygenase
FH977_RS24235	COG2188	Transcriptional regulator
FH977_RS24240	COG3624	Phosphonate C-P lyase system protein PhnG
FH977_RS24245	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FH977_RS24250	COG3626	phosphonate metabolism
FH977_RS24255	COG3627	carbon phosphorus lyase activity
FH977_RS24260	COG4107	phosphonate C-P lyase system protein PhnK
FH977_RS24265	COG4778	phosphonate C-P lyase system protein PhnL
FH977_RS24270	COG3454	Phosphonate metabolism
FH977_RS24280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FH977_RS24290	COG4191	Histidine kinase
FH977_RS24290	COG0784	Response regulator, receiver
FH977_RS24295	COG1129	ABC transporter
FH977_RS24300	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS24340	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FH977_RS24345	COG1301	dicarboxylic acid transport
FH977_RS24355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FH977_RS24360	COG3162	membrane
FH977_RS24390	COG3539	Fimbrial protein
FH977_RS24395	COG1346	cytolysis
FH977_RS24400	COG1380	Effector of murein hydrolase LrgA
FH977_RS24405	COG0583	DNA-binding transcription factor activity
FH977_RS24410	COG0025	NhaP-type Na H and K H
FH977_RS24415	COG2252	PERMEase
FH977_RS24420	COG0625	glutathione transferase activity
FH977_RS24425	COG0789	Transcriptional regulator
FH977_RS24435	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FH977_RS24470	COG1234	tRNA 3'-trailer cleavage
FH977_RS24475	COG1609	Transcriptional regulator
FH977_RS24480	COG0483	inositol monophosphate 1-phosphatase activity
FH977_RS24495	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH977_RS24515	COG4771	TonB-dependent receptor
FH977_RS24520	COG0741	lytic transglycosylase activity
FH977_RS24535	COG2315	Protein conserved in bacteria
FH977_RS24540	COG0432	Pfam Uncharacterised protein family UPF0047
FH977_RS24555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FH977_RS24560	COG0305	Participates in initiation and elongation during chromosome replication
FH977_RS24575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FH977_RS24585	COG0735	belongs to the Fur family
FH977_RS24590	COG3237	CsbD-like
FH977_RS24595	COG0534	Mate efflux family protein
FH977_RS24605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FH977_RS24675	COG0251	oxidation-reduction process
FH977_RS24685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FH977_RS24695	COG0527	aspartate kinase activity
FH977_RS24750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FH977_RS24780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FH977_RS24790	COG0456	acetyltransferase
FH977_RS24820	COG0151	Belongs to the GarS family
FH977_RS24830	COG4191	Histidine kinase
FH977_RS24835	COG3678	ATP-independent chaperone mediated protein folding
FH977_RS24870	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FH977_RS24885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FH977_RS24890	COG2104	thiamine diphosphate biosynthetic process
FH977_RS24905	COG3706	GGDEF domain
FH977_RS24915	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH977_RS24920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FH977_RS24955	COG0250	Participates in transcription elongation, termination and antitermination
FH977_RS25030	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
FH977_RS25040	COG1739	Uncharacterized protein family UPF0029
FH977_RS25080	COG0805	protein transport
FH977_RS25100	COG3165	ubiquinone biosynthetic process from chorismate
FH977_RS25130	COG0583	DNA-binding transcription factor activity
FH977_RS25135	COG0697	spore germination
FH977_RS25140	COG0561	phosphatase activity
FH977_RS25145	COG2267	carboxylic ester hydrolase activity
FH977_RS25150	COG1280	lysine exporter protein (LysE YggA)
FH977_RS25160	COG1280	lysine exporter protein (LysE YggA)
FH977_RS25190	COG0210	DNA helicase
FH977_RS25195	COG1011	Hydrolase
FH977_RS25225	COG3072	Adenylate cyclase
FH977_RS25240	COG2959	enzyme of heme biosynthesis
FH977_RS25245	COG3071	HemY protein
FH977_RS25290	COG2244	polysaccharide biosynthetic process
FH977_RS25295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FH977_RS25300	COG0456	acetyltransferase
FH977_RS25305	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FH977_RS25310	COG1088	dTDP-glucose 4,6-dehydratase activity
FH977_RS25315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FH977_RS25320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FH977_RS25330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FH977_RS25335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FH977_RS25345	COG3118	belongs to the thioredoxin family
FH977_RS25370	COG1811	Na channel or pump
FH977_RS25380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FH977_RS25385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FH977_RS25395	COG0583	DNA-binding transcription factor activity
FH977_RS25400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FH977_RS25415	COG3978	acetolactate synthase activity
FH977_RS25435	COG3085	chromosome segregation
FH977_RS25510	COG0583	DNA-binding transcription factor activity
FH977_RS25525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FH977_RS25540	COG3443	Belongs to the bacterial solute-binding protein 9 family
FH977_RS25555	COG0371	Dehydrogenase
FH977_RS25560	COG0697	spore germination
FH977_RS25570	COG0583	DNA-binding transcription factor activity
FH977_RS25590	COG0527	aspartate kinase activity
FH977_RS25590	COG0460	homoserine dehydrogenase
FH977_RS25595	COG0626	cystathionine gamma-synthase activity
FH977_RS25610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FH977_RS25615	COG1609	Transcriptional regulator
FH977_RS25620	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FH977_RS25635	COG1575	Belongs to the MenA family. Type 1 subfamily
FH977_RS25655	COG3678	ATP-independent chaperone mediated protein folding
FH977_RS25660	COG0745	RESPONSE REGULATOR receiver
FH977_RS25665	COG2205	protein histidine kinase activity
FH977_RS25670	COG2258	MOSC domain
FH977_RS25675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FH977_RS25720	COG1129	ABC transporter
FH977_RS25725	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS25730	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS25735	COG1454	alcohol dehydrogenase
FH977_RS25745	COG2211	Major facilitator Superfamily
FH977_RS25825	COG0437	4 iron, 4 sulfur cluster binding
FH977_RS25830	COG2864	formate dehydrogenase
FH977_RS25845	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FH977_RS25855	COG0456	acetyltransferase
FH977_RS25870	COG1011	Hydrolase
FH977_RS25885	COG3852	Histidine kinase
FH977_RS25900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FH977_RS25925	COG0204	Acyl-transferase
FH977_RS25940	COG3084	Protein conserved in bacteria
FH977_RS25950	COG1763	Mo-molybdopterin cofactor biosynthetic process
FH977_RS25980	COG2186	Transcriptional regulator
FH977_RS25985	COG0477	Major facilitator Superfamily
FH977_RS25995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH977_RS26005	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH977_RS26010	COG1129	ABC transporter
FH977_RS26040	COG1522	sequence-specific DNA binding
FH977_RS26045	COG0716	FMN binding
FH977_RS26060	COG3312	ion transport
FH977_RS26115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH977_RS26120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FH977_RS26125	COG0573	inorganic phosphate transmembrane transporter activity
FH977_RS26130	COG0581	inorganic phosphate transmembrane transporter activity
FH977_RS26135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FH977_RS26140	COG0704	Plays a role in the regulation of phosphate uptake
FH977_RS26155	COG2382	esterase
FH977_RS26160	COG0363	glucosamine-6-phosphate deaminase activity
FH977_RS26165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH977_RS26175	COG2252	PERMEase
FH977_RS26180	COG0431	NADPH-dependent FMN reductase
FH977_RS26185	COG2091	lysine biosynthetic process via aminoadipic acid
FH977_RS26215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane